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Search of human proteins with 112382250
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
(2364 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 4676 0.0
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 4145 0.0
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 2982 0.0
gi|67782321 spectrin beta isoform a [Homo sapiens] 2814 0.0
gi|67782319 spectrin beta isoform b [Homo sapiens] 2648 0.0
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 2175 0.0
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 929 0.0
gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [... 672 0.0
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 609 e-173
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 609 e-173
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] 570 e-162
gi|12025678 actinin, alpha 4 [Homo sapiens] 449 e-125
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens] 445 e-124
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens] 445 e-124
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens] 445 e-124
gi|4557241 actinin, alpha 3 [Homo sapiens] 432 e-120
gi|4501893 actinin, alpha 2 [Homo sapiens] 431 e-120
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 404 e-112
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 404 e-112
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 402 e-111
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 401 e-111
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 400 e-111
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 400 e-111
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 400 e-111
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 400 e-111
gi|33188445 microfilament and actin filament cross-linker protei... 361 4e-99
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi... 338 3e-92
gi|221316624 dystonin isoform 4 [Homo sapiens] 310 1e-83
gi|221316622 dystonin isoform 3 [Homo sapiens] 310 1e-83
gi|221316618 dystonin isoform 2 [Homo sapiens] 310 1e-83
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 4676 bits (12129), Expect = 0.0
Identities = 2364/2364 (100%), Positives = 2364/2364 (100%)
Query: 1 MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTF 60
MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTF
Sbjct: 1 MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTF 60
Query: 61 TKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKAL 120
TKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKAL
Sbjct: 61 TKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKAL 120
Query: 121 QFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALL 180
QFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALL
Sbjct: 121 QFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALL 180
Query: 181 LWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNL 240
LWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNL
Sbjct: 181 LWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNL 240
Query: 241 AEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIET 300
AEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIET
Sbjct: 241 AEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIET 300
Query: 301 EKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKG 360
EKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKG
Sbjct: 301 EKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKG 360
Query: 361 NLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKL 420
NLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKL
Sbjct: 361 NLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKL 420
Query: 421 EQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQA 480
EQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQA
Sbjct: 421 EQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQA 480
Query: 481 VVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYI 540
VVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYI
Sbjct: 481 VVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYI 540
Query: 541 MDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEG 600
MDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEG
Sbjct: 541 MDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEG 600
Query: 601 YKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKI 660
YKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKI
Sbjct: 601 YKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKI 660
Query: 661 LSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERII 720
LSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERII
Sbjct: 661 LSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERII 720
Query: 721 YIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQ 780
YIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQ
Sbjct: 721 YIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQ 780
Query: 781 SLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRL 840
SLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRL
Sbjct: 781 SLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRL 840
Query: 841 RKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNN 900
RKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNN
Sbjct: 841 RKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNN 900
Query: 901 QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNY 960
QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNY
Sbjct: 901 QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNY 960
Query: 961 HLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAE 1020
HLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAE
Sbjct: 961 HLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAE 1020
Query: 1021 KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSR 1080
KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSR
Sbjct: 1021 KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSR 1080
Query: 1081 TQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFL 1140
TQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFL
Sbjct: 1081 TQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFL 1140
Query: 1141 RQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTT 1200
RQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTT
Sbjct: 1141 RQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTT 1200
Query: 1201 LEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKN 1260
LEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKN
Sbjct: 1201 LEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKN 1260
Query: 1261 RETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFM 1320
RETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFM
Sbjct: 1261 RETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFM 1320
Query: 1321 AELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDAN 1380
AELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDAN
Sbjct: 1321 AELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDAN 1380
Query: 1381 KAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQ 1440
KAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQ
Sbjct: 1381 KAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQ 1440
Query: 1441 SQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILW 1500
SQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILW
Sbjct: 1441 SQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILW 1500
Query: 1501 VGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSA 1560
VGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSA
Sbjct: 1501 VGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSA 1560
Query: 1561 EAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEK 1620
EAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEK
Sbjct: 1561 EAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEK 1620
Query: 1621 AKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLY 1680
AKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLY
Sbjct: 1621 AKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLY 1680
Query: 1681 AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERF 1740
AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERF
Sbjct: 1681 AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERF 1740
Query: 1741 REFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQI 1800
REFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQI
Sbjct: 1741 REFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQI 1800
Query: 1801 LAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQV 1860
LAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQV
Sbjct: 1801 LAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQV 1860
Query: 1861 RQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMV 1920
RQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMV
Sbjct: 1861 RQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMV 1920
Query: 1921 RDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR 1980
RDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR
Sbjct: 1921 RDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR 1980
Query: 1981 KHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL 2040
KHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL
Sbjct: 1981 KHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL 2040
Query: 2041 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRP 2100
SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRP
Sbjct: 2041 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRP 2100
Query: 2101 PSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTS 2160
PSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTS
Sbjct: 2101 PSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTS 2160
Query: 2161 SKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKASSR 2220
SKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKASSR
Sbjct: 2161 SKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKASSR 2220
Query: 2221 SWHNVYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLN 2280
SWHNVYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLN
Sbjct: 2221 SWHNVYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLN 2280
Query: 2281 DGNEYLFQAKDDEEMNTWIQAISSAISSDKHEVSASTQSTPASSRAQTLPTSVVTITSES 2340
DGNEYLFQAKDDEEMNTWIQAISSAISSDKHEVSASTQSTPASSRAQTLPTSVVTITSES
Sbjct: 2281 DGNEYLFQAKDDEEMNTWIQAISSAISSDKHEVSASTQSTPASSRAQTLPTSVVTITSES 2340
Query: 2341 SPGKREKDKEKDKEKRFSLFGKKK 2364
SPGKREKDKEKDKEKRFSLFGKKK
Sbjct: 2341 SPGKREKDKEKDKEKRFSLFGKKK 2364
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 4145 bits (10749), Expect = 0.0
Identities = 2098/2120 (98%), Positives = 2104/2120 (99%)
Query: 44 RIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKP 103
R K L DEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKP
Sbjct: 31 RFKQLQDEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKP 90
Query: 104 TKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDIS 163
TKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDIS
Sbjct: 91 TKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDIS 150
Query: 164 VETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFD 223
VETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFD
Sbjct: 151 VETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFD 210
Query: 224 KLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKAL 283
KLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKAL
Sbjct: 211 KLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKAL 270
Query: 284 AVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQA 343
AVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQA
Sbjct: 271 AVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQA 330
Query: 344 FNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAE 403
FNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAE
Sbjct: 331 FNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAE 390
Query: 404 HERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKK 463
HERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKK
Sbjct: 391 HERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKK 450
Query: 464 HEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQR 523
HEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQR
Sbjct: 451 HEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQR 510
Query: 524 LEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAER 583
LEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAER
Sbjct: 511 LEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAER 570
Query: 584 VRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKF 643
VRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKF
Sbjct: 571 VRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKF 630
Query: 644 FWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGED 703
FWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGED
Sbjct: 631 FWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGED 690
Query: 704 MIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDI 763
MIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDI
Sbjct: 691 MIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDI 750
Query: 764 LKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGR 823
LKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGR
Sbjct: 751 LKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGR 810
Query: 824 LSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLED 883
LSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLED
Sbjct: 811 LSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLED 870
Query: 884 LEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFREL 943
LEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFREL
Sbjct: 871 LEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFREL 930
Query: 944 VDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMER 1003
VDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMER
Sbjct: 931 VDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMER 990
Query: 1004 DLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASK 1063
DLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASK
Sbjct: 991 DLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASK 1050
Query: 1064 LQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRD 1123
LQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRD
Sbjct: 1051 LQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRD 1110
Query: 1124 MGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEA 1183
MGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEA
Sbjct: 1111 MGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEA 1170
Query: 1184 FLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINS 1243
FLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINS
Sbjct: 1171 FLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINS 1230
Query: 1244 DRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSY 1303
DRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSY
Sbjct: 1231 DRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSY 1290
Query: 1304 DEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWE 1363
DEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWE
Sbjct: 1291 DEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWE 1350
Query: 1364 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1423
VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ
Sbjct: 1351 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1410
Query: 1424 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLA 1483
MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLA
Sbjct: 1411 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLA 1470
Query: 1484 SKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDD 1543
SKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDD
Sbjct: 1471 SKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDD 1530
Query: 1544 IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAE 1603
IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAE
Sbjct: 1531 IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAE 1590
Query: 1604 AEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSH 1663
AEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSH
Sbjct: 1591 AEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSH 1650
Query: 1664 PESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGS 1723
PESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGS
Sbjct: 1651 PESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGS 1710
Query: 1724 HELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGL 1783
HELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGL
Sbjct: 1711 HELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGL 1770
Query: 1784 NEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQ 1843
NEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQ
Sbjct: 1771 NEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQ 1830
Query: 1844 RMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESR 1903
RMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESR
Sbjct: 1831 RMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESR 1890
Query: 1904 RVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDAR 1963
RVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDAR
Sbjct: 1891 RVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDAR 1950
Query: 1964 NDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFS 2023
NDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFS
Sbjct: 1951 NDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFS 2010
Query: 2024 RDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLE 2083
RDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLE
Sbjct: 2011 RDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLE 2070
Query: 2084 LLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAE 2143
LLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPR++
Sbjct: 2071 LLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRVSY 2130
Query: 2144 TVDTSEMVNGATEQRTSSKE 2163
T + +RT+S +
Sbjct: 2131 RSQTYQNYKNFNSRRTASDQ 2150
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 2982 bits (7731), Expect = 0.0
Identities = 1494/2400 (62%), Positives = 1866/2400 (77%), Gaps = 49/2400 (2%)
Query: 2 TTTVATDYDNIEIQQQYSDVNNRWDV--DDWDNENSSARLFERSRIKALADEREAVQKKT 59
+T TD+D++EIQ QYSD+NNRWD+ DWDN++SSARLFERSRIKALADEREAVQKKT
Sbjct: 3 STLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKT 62
Query: 60 FTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKA 119
FTKWVNSHLARV+CR+ DLY+DLRDGR L++LLEVLSGE LPKPTKGRMRIHCLENVDKA
Sbjct: 63 FTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKA 122
Query: 120 LQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDAL 179
LQFLKEQ+VHLENMGSHDIVDGNHRLTLGL+WTIILRFQIQDISVETEDNKEKKSAKDAL
Sbjct: 123 LQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDAL 182
Query: 180 LLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFN 239
LLWCQMKTAGYPNVN+HNFTTSWRDG+AFNA++HKHRPDL+DF+ LKK NAHYNLQNAFN
Sbjct: 183 LLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFN 242
Query: 240 LAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIE 299
LAE+ LGLTKLLDPED++VD PDEKSIITYV TYYHYFSKMKALAVEGKRIGKVLD+A+E
Sbjct: 243 LAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAME 302
Query: 300 TEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEK 359
E+++EKYESLAS+LL+WIEQTI+ LN+R+ ANSL GVQ QLQ+FN+YRTVEKPPKFTEK
Sbjct: 303 AERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEK 362
Query: 360 GNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEK 419
GNLEVLLFTIQSK+RANNQKVY PREG+LISDINKAWERLEKAEHERELALR ELIRQEK
Sbjct: 363 GNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEK 422
Query: 420 LEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQ 479
LEQLA RFDRKAAMRETWLSENQRLVSQDNFG +L AVEAA +KHEAIETDI AY RVQ
Sbjct: 423 LEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQ 482
Query: 480 AVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY 539
AV AVA EL AE YHDIKRI AR+ NV RLW++L +++ ARR+RL +NL LQK+FQ++LY
Sbjct: 483 AVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLY 542
Query: 540 IMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGE 599
+MDWM+EMK + SQD G+HL GVEDLLQ H LVEADI +QAERVR V+ASA +F G+
Sbjct: 543 LMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGK 602
Query: 600 GYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEK 659
Y+PCDPQ++ +RVA +E Y+ LC+LAA RRARLEESRRLW+F WE+ E E W+RE++
Sbjct: 603 EYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQH 662
Query: 660 ILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERI 719
+L+S D G+DLT +RLL+KH A EMSGR G + +++G+ ++AE H G+ + R
Sbjct: 663 LLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARA 722
Query: 720 IYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYST 779
++ QW LE L+ R +RL +A+ L+QFQADA+D++AW++D L++VSS ++GHDE+ST
Sbjct: 723 AELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFST 782
Query: 780 QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTR 839
Q+L ++H+ + EEI ++RPTLD L EQA+ALP + +P+V+GR+ +E Y+E+
Sbjct: 783 QALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAG 842
Query: 840 LRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMN 899
R +AL+ LALY M SEA AC LW++EKEQWLN + +PE+LEDLEV+Q RFE+LEPEMN
Sbjct: 843 ERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMN 902
Query: 900 NQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQN 959
A+++ VN IA QL+ + P + I Q++LN RW QFR L D KK AL SALSIQN
Sbjct: 903 TLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQN 962
Query: 960 YHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEA 1019
YHLEC ET++W+REKTKVIESTQ LGNDLAGV+ALQRKL G ERDL AI A++ +L +EA
Sbjct: 963 YHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREA 1022
Query: 1020 EKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLS 1079
L + HP QA AI +RL E+ WE+++ T++ RE SLGEA +LQ FLR LDDFQ+WL
Sbjct: 1023 NALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLG 1082
Query: 1080 RTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMF 1139
RTQTA+ASE+ P TL EAE LL QH ++ E++ + +Y ++R +GE VT+ Q D Q +F
Sbjct: 1083 RTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLF 1142
Query: 1140 LRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPT 1199
LRQRL+AL TGW EL +MWE+RQ L+Q+H +Q FLRD +QAE L++QEYVL+HTEMP
Sbjct: 1143 LRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPG 1202
Query: 1200 TLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRK 1259
TL+ A+AAIKK EDFM+TMDAN E+I+ ++E GR+LVS+GNI++D+I+EK DSI+ RH+K
Sbjct: 1203 TLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKK 1262
Query: 1260 NRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAF 1319
N++ A + L RL+DNR+ Q FLQDC EL LWI+EKMLTAQD+SYDEARNLH+KW KHQAF
Sbjct: 1263 NQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAF 1322
Query: 1320 MAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA 1379
MAELA+NK+WLDK++KEG +L EKPE +A+V EKL LH+ W+ LE+TTQ KA+ LFDA
Sbjct: 1323 MAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDA 1382
Query: 1380 NKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEEL 1439
N+AELF QSC L+ WL L++Q+ SDDYGKDLTSVNILLKKQQMLE +M VR+KE+E +
Sbjct: 1383 NRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAI 1442
Query: 1440 QSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEIL 1499
Q+QA+AL+QE + EV+ V+ KF L +P+ ER L AS+E HQF+RDVEDEIL
Sbjct: 1443 QAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEIL 1502
Query: 1500 WVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLS 1559
WV ER+P+A+S +HG +L +VQLL+KKNQTLQKEIQGH+PRI D+ ER + +L
Sbjct: 1503 WVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQR-------ALG 1555
Query: 1560 AEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEE 1619
A A LA+L+++W L E E R +RLE+A RAQQ+Y DAAEAEAWM EQEL+MM +E
Sbjct: 1556 AAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQE 1615
Query: 1620 KAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKL 1679
KAKDE SA + +KKHQ+LEQA+ DYA+T+HQL+ +S+ ++ HPES RIS+RQ++VDKL
Sbjct: 1616 KAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKL 1675
Query: 1680 YAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQER 1739
YAGLK+LA ERR +L E RL QL RE+DDLEQWI EREVVA SHELGQDYEHVTML+++
Sbjct: 1676 YAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDK 1735
Query: 1740 FREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQ 1799
FREF+RDT IGQERVD+ N LA+ LI GH+ AT+AEWKD LNEAWADLLEL+DTR Q
Sbjct: 1736 FREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQ 1795
Query: 1800 ILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQ 1859
+LAA+YEL +F H A++ R+Q K ++LP+ GRD N E LQR H +EHDIQAL Q
Sbjct: 1796 VLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQ 1855
Query: 1860 VRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSM 1919
V+Q+Q+D RLQ AYAGDKA++I + V EAW L + +RR L+DT DKFRFF
Sbjct: 1856 VQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKA 1915
Query: 1920 VRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLA 1979
VR+LMLWM++V Q++AQE+PRDVSS +L++ N QGIKAEI+AR D F++CI++GK LLA
Sbjct: 1916 VRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLA 1975
Query: 1980 RKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPY 2039
R HYA+EEI EKL QL +R+E +KW+++ +WL+L+LEV F RDA +AEAWL QEP
Sbjct: 1976 RSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPL 2035
Query: 2040 LSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEV--RRQQEEEERK 2097
+ S E+G +VDEVE LIKRHEAF+KSA W+ERF ALE+LT LE E +R++EEEER+
Sbjct: 2036 VRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERR 2095
Query: 2098 RRPPSPEPSTK------VSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMV 2151
++PP+PEP+ V + S WD ++ P+ G + + S+ +
Sbjct: 2096 KQPPAPEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQAPSVNG---VCTDGEPSQPL 2152
Query: 2152 NGATEQRTSSKESSPIP-------SPTSDRKAKTALPAQS------------AATLPART 2192
G SS P P P +R+ +T PA S AATLP R
Sbjct: 2153 LGQQRLEHSSFPEGPGPGSGDEANGPRGERQTRTRGPAPSAMPQSRSTESAHAATLPPRG 2212
Query: 2193 QETPSA--QMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTAASGIPYH 2250
E PSA QMEG L RK E EA KKA++RSW NVYCV+ +GFYKDAK A++G+PYH
Sbjct: 2213 PE-PSAQEQMEGMLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYH 2271
Query: 2251 SEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAI---- 2306
EVPVSL A VA DY+K+KHVFKL L DG EYLFQAKD+ EM++W++ +++AI
Sbjct: 2272 GEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATAS 2331
Query: 2307 -SSDKHEVSASTQSTPASSRAQTLPTSVVTITSESSPGKREKD-KEKDKEKRFSLFGKKK 2364
+S + E +T +RA T+P V + +E R KD +E+++EKRFS F K K
Sbjct: 2332 SASGEPEEPVVPSTTRGMTRAMTMP-PVSPVGAEGPVVLRSKDGREREREKRFSFFKKNK 2390
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 2814 bits (7295), Expect = 0.0
Identities = 1397/2368 (58%), Positives = 1803/2368 (76%), Gaps = 48/2368 (2%)
Query: 4 TVATDYDNIEIQQQYSDVNNRWDV--DDWDNENSSARLFERSRIKALADEREAVQKKTFT 61
T AT+++N+ Q YS +N RWD D+ DN+NSSARLFERSRIKALADERE VQKKTFT
Sbjct: 2 TSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTFT 61
Query: 62 KWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQ 121
KWVNSHLARVSCRITDLY DLRDGRMLIKLLEVLSGE LPKPTKG+MRIHCLENVDKALQ
Sbjct: 62 KWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKALQ 121
Query: 122 FLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLL 181
FLKEQRVHLENMGSHDIVDGNHRL LGLIWTIILRFQIQDI V+T++ +E +SAKDALLL
Sbjct: 122 FLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALLL 181
Query: 182 WCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLA 241
WCQMKTAGYP+VN+ NFT+SW+DG+AFNALIHKHRPDLIDFDKLK SNA +NL++AFN+A
Sbjct: 182 WCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNVA 241
Query: 242 EQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETE 301
E+ LG+ LLDPED+ ++PDEKSIITYVV +YHYFSKMK LAVEGKR+GKV+D+AIETE
Sbjct: 242 ERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIETE 301
Query: 302 KMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGN 361
KMIEKY LASDLL WIEQTI +LN+RKFANSL GVQQQLQAF+TYRTVEKPPKF EKGN
Sbjct: 302 KMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGN 361
Query: 362 LEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLE 421
LEVLLFTIQS+MRANNQKVY P +GKL+SDIN+AWE LE+AE+ RELALRNELIRQEKLE
Sbjct: 362 LEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLE 421
Query: 422 QLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAV 481
QLARRFDRKAAMRETWLSENQRLV+QDNFG+DL AVEAA KKHEAIETD AAYEERV+A+
Sbjct: 422 QLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRAL 481
Query: 482 VAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIM 541
+A+ELE ENYHD KRITARKDN++RLW YL ELL++RRQRLE L LQK+FQ+ML+ +
Sbjct: 482 EDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI 541
Query: 542 DWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGY 601
DWMDE+K +LS ++GKHLL VEDLLQKH L+EADI IQ ++V+ + A+ KF T+G+GY
Sbjct: 542 DWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF-TEGKGY 600
Query: 602 KPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKIL 661
+PCDPQVI+DR++H+E C++EL +AA R+A+LE+S+RLWKFFWEM E E WI+EKE+I
Sbjct: 601 QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
Query: 662 SSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIY 721
SS DYGKDLTSV+ L KH+AFEDE+ G H EQ +E M+A + FG +I RI
Sbjct: 661 SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE 720
Query: 722 IREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQS 781
+ QW L+ L+A KK L++A QFQ DADD+ AW+ D +++S DVG DE +T++
Sbjct: 721 VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA 780
Query: 782 LVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLR 841
L KKHKD EE+ R ++ L +QA P+E +SPDV RL + E Y++V LR
Sbjct: 781 LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR 840
Query: 842 KQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQ 901
+Q LQ+ L LY +F E DACELW+ EKE+WL M++P+ LEDLEV+QHRF+ L+ EM
Sbjct: 841 QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL 900
Query: 902 ASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYH 961
+++ VN A L+ SGHP +E+K QD LNTRW F+ LV +++A+ SAL + NY
Sbjct: 901 MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC 960
Query: 962 LECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEK 1021
++C ET WI +KTKV+EST+DLG DLAG++A+QRKL+G+ERD+ AI+A++ L++E+++
Sbjct: 961 VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ 1020
Query: 1022 LESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRT 1081
L HP+Q + I R + ++W+ ++ +L+ +E LGE S+LQ FL+DLDDFQ+WLS T
Sbjct: 1021 LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080
Query: 1082 QTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1141
Q A+ASEDMP +L EAE+LL QH IK+EID +++ YQ++++ GE V QGQTD +Y+ L
Sbjct: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140
Query: 1142 QRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTL 1201
QRL+ LDTGWN L +MWE+R + L+Q +Q+F +D KQAEA L+NQEY LAH E P +L
Sbjct: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
Query: 1202 EGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNR 1261
E AEA I+K EDF+ +M+ N +K+ + V++G +LV++GN+ SD+I+EKV I+DRHRKN
Sbjct: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN 1260
Query: 1262 ETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMA 1321
E A E + L+DN +LQ FLQ+CQEL+LWIN+K+LT+QD+SYDEARNLH+KWLKHQAF+A
Sbjct: 1261 EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA 1320
Query: 1322 ELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANK 1381
ELAS++ WL+ I+ EG QL+ EKP+ A+V +KL LH++W+ L++TT+ K Q L A
Sbjct: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
Query: 1382 AELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQS 1441
++L Q+ ADL+KW+ +E Q++SDD GKDLTSVN +L K + +E+Q+ VRK+E+ EL +
Sbjct: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
Query: 1442 QAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWV 1501
Q ++ +EG D L+++ +F++LLEPL RK L +S+ Q +RD+EDE LWV
Sbjct: 1441 QVPSMGEEGGDAD------LSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWV 1494
Query: 1502 GERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE 1561
ER+PLA S D+G NLQTVQL +KKNQTLQ EI GH PR++D+ +R Q +V +++ + +
Sbjct: 1495 EERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLV-EAAEIDCQ 1553
Query: 1562 AIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKA 1621
+ +RL L+ W L E R +RL +A+ AQQYY DA EAEAW+ EQELY++S+E
Sbjct: 1554 DLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIP 1613
Query: 1622 KDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA 1681
KDE+ A+ MLK+H ++AVEDY + QL+ ++ L++ HPE E+I Q +VDK YA
Sbjct: 1614 KDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYA 1673
Query: 1682 GLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFR 1741
GLKD+AEER+ KL+ + LFQL RE DDLEQWI+E+E+VA S E+GQD++HVT+L+++FR
Sbjct: 1674 GLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFR 1733
Query: 1742 EFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQIL 1801
+FAR+TG IGQERVD VN + LI++GHS+AATIAEWKDGLNE WADLLELIDTR Q+L
Sbjct: 1734 DFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLL 1793
Query: 1802 AASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVR 1861
AASY+LH++++ EI G I +KH++LPE++G D +T E+ R+HT FE ++ LG QV+
Sbjct: 1794 AASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQ 1853
Query: 1862 QLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVR 1921
Q Q+ A RLQ AYAG+KA+ IQ +E EV AW++LLDAC RR +LVDT DKFRFFSM R
Sbjct: 1854 QFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMAR 1913
Query: 1922 DLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARK 1981
DL+ WME +IRQIE QE+PRDVSSVELLM HQGI AEI+ R+ +F+ C+ELG+SLL R+
Sbjct: 1914 DLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ 1973
Query: 1982 HYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLS 2041
H ASEEI+EKL Q+ +RKEM +KWE RWE LR++LEV QFSRDASVAEAWL+ QEPYL+
Sbjct: 1974 HQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLA 2033
Query: 2042 SREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPP 2101
S + G +VD VEKLIKRHEAFEKS A+W ERF+ALE+ TTLEL +E + RP
Sbjct: 2034 SGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLEL-------KERQIAERP- 2085
Query: 2102 SPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAE-TVDTSEMVNGATEQRTS 2160
+EE Q++ + GE + E+ SP E T + Q
Sbjct: 2086 --------AEETGPQEEEGETAGEAPVSHHAATERTSPGEEEGTWPQNLQQPPPPGQHKD 2137
Query: 2161 SKESSPIPSPTSDRKAKT----ALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKK 2216
++S+ PT++ K ATLPA S QMEG+L RKH+ E NKK
Sbjct: 2138 GQKSTGDERPTTEPLFKVLDTPLSEGDEPATLPAPRDHGQSVQMEGYLGRKHDLEGPNKK 2197
Query: 2217 ASSRSWHNVYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFK 2276
AS+RSW+N+YCV+ N E+ FYKDAK A G+PYH E P++L+ A+CE+A +YKKKKHVFK
Sbjct: 2198 ASNRSWNNLYCVLRNSELTFYKDAKNLALGMPYHGEEPLALRHAICEIAANYKKKKHVFK 2257
Query: 2277 LRLNDGNEYLFQAKDDEEMNTWIQAISSAISSDKHEVSASTQSTPASSRAQTLPTSVVTI 2336
LRL++G+E+LF KD+EEM +W+Q +S+AI+ +S +AQ+LP ++
Sbjct: 2258 LRLSNGSEWLFHGKDEEEMLSWLQGVSTAIN----------ESQSIRVKAQSLPLPSLS- 2306
Query: 2337 TSESSPGKREKDKEKDKEKRFSLFGKKK 2364
++S GK KDKEKRFS F KKK
Sbjct: 2307 GPDASLGK------KDKEKRFSFFPKKK 2328
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 2648 bits (6864), Expect = 0.0
Identities = 1293/2110 (61%), Positives = 1655/2110 (78%), Gaps = 12/2110 (0%)
Query: 4 TVATDYDNIEIQQQYSDVNNRWDV--DDWDNENSSARLFERSRIKALADEREAVQKKTFT 61
T AT+++N+ Q YS +N RWD D+ DN+NSSARLFERSRIKALADERE VQKKTFT
Sbjct: 2 TSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTFT 61
Query: 62 KWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQ 121
KWVNSHLARVSCRITDLY DLRDGRMLIKLLEVLSGE LPKPTKG+MRIHCLENVDKALQ
Sbjct: 62 KWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKALQ 121
Query: 122 FLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLL 181
FLKEQRVHLENMGSHDIVDGNHRL LGLIWTIILRFQIQDI V+T++ +E +SAKDALLL
Sbjct: 122 FLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALLL 181
Query: 182 WCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLA 241
WCQMKTAGYP+VN+ NFT+SW+DG+AFNALIHKHRPDLIDFDKLK SNA +NL++AFN+A
Sbjct: 182 WCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNVA 241
Query: 242 EQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETE 301
E+ LG+ LLDPED+ ++PDEKSIITYVV +YHYFSKMK LAVEGKR+GKV+D+AIETE
Sbjct: 242 ERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIETE 301
Query: 302 KMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGN 361
KMIEKY LASDLL WIEQTI +LN+RKFANSL GVQQQLQAF+TYRTVEKPPKF EKGN
Sbjct: 302 KMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGN 361
Query: 362 LEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLE 421
LEVLLFTIQS+MRANNQKVY P +GKL+SDIN+AWE LE+AE+ RELALRNELIRQEKLE
Sbjct: 362 LEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLE 421
Query: 422 QLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAV 481
QLARRFDRKAAMRETWLSENQRLV+QDNFG+DL AVEAA KKHEAIETD AAYEERV+A+
Sbjct: 422 QLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRAL 481
Query: 482 VAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIM 541
+A+ELE ENYHD KRITARKDN++RLW YL ELL++RRQRLE L LQK+FQ+ML+ +
Sbjct: 482 EDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI 541
Query: 542 DWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGY 601
DWMDE+K +LS ++GKHLL VEDLLQKH L+EADI IQ ++V+ + A+ KF T+G+GY
Sbjct: 542 DWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF-TEGKGY 600
Query: 602 KPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKIL 661
+PCDPQVI+DR++H+E C++EL +AA R+A+LE+S+RLWKFFWEM E E WI+EKE+I
Sbjct: 601 QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
Query: 662 SSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIY 721
SS DYGKDLTSV+ L KH+AFEDE+ G H EQ +E M+A + FG +I RI
Sbjct: 661 SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE 720
Query: 722 IREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQS 781
+ QW L+ L+A KK L++A QFQ DADD+ AW+ D +++S DVG DE +T++
Sbjct: 721 VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA 780
Query: 782 LVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLR 841
L KKHKD EE+ R ++ L +QA P+E +SPDV RL + E Y++V LR
Sbjct: 781 LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR 840
Query: 842 KQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQ 901
+Q LQ+ L LY +F E DACELW+ EKE+WL M++P+ LEDLEV+QHRF+ L+ EM
Sbjct: 841 QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL 900
Query: 902 ASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYH 961
+++ VN A L+ SGHP +E+K QD LNTRW F+ LV +++A+ SAL + NY
Sbjct: 901 MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC 960
Query: 962 LECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEK 1021
++C ET WI +KTKV+EST+DLG DLAG++A+QRKL+G+ERD+ AI+A++ L++E+++
Sbjct: 961 VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ 1020
Query: 1022 LESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRT 1081
L HP+Q + I R + ++W+ ++ +L+ +E LGE S+LQ FL+DLDDFQ+WLS T
Sbjct: 1021 LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080
Query: 1082 QTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1141
Q A+ASEDMP +L EAE+LL QH IK+EID +++ YQ++++ GE V QGQTD +Y+ L
Sbjct: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140
Query: 1142 QRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTL 1201
QRL+ LDTGWN L +MWE+R + L+Q +Q+F +D KQAEA L+NQEY LAH E P +L
Sbjct: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
Query: 1202 EGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNR 1261
E AEA I+K EDF+ +M+ N +K+ + V++G +LV++GN+ SD+I+EKV I+DRHRKN
Sbjct: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN 1260
Query: 1262 ETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMA 1321
E A E + L+DN +LQ FLQ+CQEL+LWIN+K+LT+QD+SYDEARNLH+KWLKHQAF+A
Sbjct: 1261 EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA 1320
Query: 1322 ELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANK 1381
ELAS++ WL+ I+ EG QL+ EKP+ A+V +KL LH++W+ L++TT+ K Q L A
Sbjct: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
Query: 1382 AELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQS 1441
++L Q+ ADL+KW+ +E Q++SDD GKDLTSVN +L K + +E+Q+ VRK+E+ EL +
Sbjct: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
Query: 1442 QAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWV 1501
Q ++ +EG D L+++ +F++LLEPL RK L +S+ Q +RD+EDE LWV
Sbjct: 1441 QVPSMGEEGGDAD------LSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWV 1494
Query: 1502 GERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE 1561
ER+PLA S D+G NLQTVQL +KKNQTLQ EI GH PR++D+ +R Q +V +++ + +
Sbjct: 1495 EERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLV-EAAEIDCQ 1553
Query: 1562 AIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKA 1621
+ +RL L+ W L E R +RL +A+ AQQYY DA EAEAW+ EQELY++S+E
Sbjct: 1554 DLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIP 1613
Query: 1622 KDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA 1681
KDE+ A+ MLK+H ++AVEDY + QL+ ++ L++ HPE E+I Q +VDK YA
Sbjct: 1614 KDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYA 1673
Query: 1682 GLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFR 1741
GLKD+AEER+ KL+ + LFQL RE DDLEQWI+E+E+VA S E+GQD++HVT+L+++FR
Sbjct: 1674 GLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFR 1733
Query: 1742 EFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQIL 1801
+FAR+TG IGQERVD VN + LI++GHS+AATIAEWKDGLNE WADLLELIDTR Q+L
Sbjct: 1734 DFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLL 1793
Query: 1802 AASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVR 1861
AASY+LH++++ EI G I +KH++LPE++G D +T E+ R+HT FE ++ LG QV+
Sbjct: 1794 AASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQ 1853
Query: 1862 QLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVR 1921
Q Q+ A RLQ AYAG+KA+ IQ +E EV AW++LLDAC RR +LVDT DKFRFFSM R
Sbjct: 1854 QFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMAR 1913
Query: 1922 DLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARK 1981
DL+ WME +IRQIE QE+PRDVSSVELLM HQGI AEI+ R+ +F+ C+ELG+SLL R+
Sbjct: 1914 DLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ 1973
Query: 1982 HYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLS 2041
H ASEEI+EKL Q+ +RKEM +KWE RWE LR++LEV QFSRDASVAEAWL+ QEPYL+
Sbjct: 1974 HQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLA 2033
Query: 2042 SREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPP 2101
S + G +VD VEKLIKRHEAFEKS A+W ERF+ALE+ TTLEL E RQ E + P
Sbjct: 2034 SGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKE--RQIAERPAEETGP 2091
Query: 2102 SPEPSTKVSE 2111
E E
Sbjct: 2092 QEEEGETAGE 2101
Score = 259 bits (663), Expect = 2e-68
Identities = 277/1456 (19%), Positives = 605/1456 (41%), Gaps = 79/1456 (5%)
Query: 740 LEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHD---------EYSTQSLVKKHKDVA 790
+E ++ ++ A D+ W+ + +++S + +ST V+K
Sbjct: 298 IETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQ 357
Query: 791 EEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA 850
E+ N L T+ + A Q+ +P +S I ++ + E R+ AL++ L
Sbjct: 358 EK-GNLEVLLFTIQSRMRANNQK-VYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI 415
Query: 851 -------LYKMFSEADAC-ELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQA 902
L + F A E W+ E ++ + L +E + + E++E +
Sbjct: 416 RQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYE 475
Query: 903 SRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHL 962
RV + +A++L + +K I A++D + WS +EL+ ++ L + L++Q
Sbjct: 476 ERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQ 535
Query: 963 ECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL 1022
+ + W+ E K + + G L V L +K ME D+ K+ + K
Sbjct: 536 DMLHSIDWMDE-IKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF 594
Query: 1023 ---ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLS 1079
+ P Q I R++ + +EE+ R+A L ++ +L +F ++D+ +SW+
Sbjct: 595 TEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIK 654
Query: 1080 RTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKM-RDMGEMVTQGQTDAQYM 1138
+ +S D LT L +H+ ++E+ + +++ ++ MV + Q +
Sbjct: 655 EKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFG--HP 712
Query: 1139 FLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMP 1198
+ R++ + W++L + + L + + QF D +A+L + +L+ ++
Sbjct: 713 QIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVG 772
Query: 1199 TTLEGAEAAI-KKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRH 1257
EGA A+ KK +DF+ ++ + + + + + + + D + ++ ++ + +
Sbjct: 773 QD-EGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD-VTHRLQALRELY 830
Query: 1258 RKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSY-DEARNLHSKWLKH 1316
++ A RL++ DL + LW+ EK +M D +L +
Sbjct: 831 QQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRF 890
Query: 1317 QAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL 1376
E+ + +D + L+ VK+ L+ W+ ++ + + +
Sbjct: 891 DILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV 950
Query: 1377 FDANKAELFTQSCADLDKWLHGLESQIQSD-DYGKDLTSVNILLKKQQMLENQMEVRKKE 1435
A + + C + KW+ ++S D G+DL + + +K LE + +
Sbjct: 951 DSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQAR 1010
Query: 1436 IEELQSQAQAL-SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDV 1494
++ L+ ++Q L + +++ ++ ++ + L + L ++ L ++ F +D+
Sbjct: 1011 VDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
Query: 1495 EDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTD 1554
+D W+ S D +L + L++++ ++ EI GHQ + E + ++
Sbjct: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG 1130
Query: 1555 SSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELY 1614
+ + QRL L W L E R L + Q++ DA +AEA +S QE
Sbjct: 1131 QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYT 1190
Query: 1615 MMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQS 1674
+ E ++A + ++K + ++E+ + V + LVA+ + S++I +
Sbjct: 1191 LAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQ 1250
Query: 1675 KVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVT 1734
++ + + A+E L + L + +L WI ++ + + Y+
Sbjct: 1251 LIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQD----VSYDEAR 1306
Query: 1735 MLQERFREFARDTGNIGQER--VDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLE 1792
L ++ + + ++ ++ +L++ A +++ + L+ W +L
Sbjct: 1307 NLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQA 1366
Query: 1793 LIDTRTQILAA--SYELHKFYH-DAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTF 1849
+TQ L+A S +L H D + ++D+ + ++ G+D +V +
Sbjct: 1367 TTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRS--DDPGKDLTSVNRMLAKLKRV 1424
Query: 1850 EHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVD 1909
E + ++ +L + GD I+KR ++LE ES R +L
Sbjct: 1425 EDQVNVRKEELGELFAQVPSM-GEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQI 1483
Query: 1910 TGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTT 1969
+ D + D LW+E+ + ++ + ++ +V+L M +Q ++ EI
Sbjct: 1484 SRD-------LEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVED 1536
Query: 1970 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2029
++ G+ L+ ++++E+L L + + R + LR E Q+ DA A
Sbjct: 1537 VLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEA 1596
Query: 2030 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL-ERLTTL------ 2082
EAW+ QE Y+ S EI + + ++KRH +++ + L R L
Sbjct: 1597 EAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHP 1656
Query: 2083 ---ELLEVRRQQEE---------EERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQN 2130
+++ ++ Q ++ EERKR+ + ++ E + +QW +S+
Sbjct: 1657 EGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQW-------ISEK 1709
Query: 2131 GLPAEQGSPRMAETVD 2146
L A SP M + D
Sbjct: 1710 ELVA--SSPEMGQDFD 1723
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
sapiens]
Length = 2564
Score = 2175 bits (5637), Expect = 0.0
Identities = 1123/2139 (52%), Positives = 1510/2139 (70%), Gaps = 55/2139 (2%)
Query: 5 VATDYDNIE-IQQQYSDVNNRWDVDD--WDNEN-----SSARLFERSRIKALADEREAVQ 56
V + DN+E + ++ RW+ D W+ E ++A LFE SRIKALADEREAVQ
Sbjct: 4 VPGEVDNMEGLPAPNNNPAARWESPDRGWEREQPAASTAAASLFECSRIKALADEREAVQ 63
Query: 57 KKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENV 116
KKTFTKWVNSHLARV C I DLY DLRDG +L +LLEVLSGE+LP+PT+GRMRIH LENV
Sbjct: 64 KKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLENV 123
Query: 117 DKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAK 176
DKALQFLKEQRVHLEN+GSHDIVDGNHRLTLGL+WTIILRFQIQ I +ETEDN+E +SAK
Sbjct: 124 DKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAK 183
Query: 177 DALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQN 236
DALLLWCQMKTAGYP VNI NFTTSWRDG+AFNALIH+HRPDL+DF KL KSNA+YNLQ
Sbjct: 184 DALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANYNLQR 243
Query: 237 AFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDN 296
AF AEQHLGL +LLDPED++++ PDEKSIITYVV++YHYFSKMKALAVEGKRIGKVLD
Sbjct: 244 AFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQ 303
Query: 297 AIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKF 356
+E K+IE+YE LA++LL WI +T+ +++N+KFANSL GVQQQLQAF Y T+EKP KF
Sbjct: 304 VLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKF 363
Query: 357 TEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIR 416
EKGNLEVLLF+IQSK+RA N+++++PREG I DI+KAW LEKAEHERE ALR ELIR
Sbjct: 364 QEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIR 423
Query: 417 QEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEE 476
QEKLE LA+RFD K AMRE+WL+ENQRLVSQDNFG++LPAVEAA KKHEAIE DIAAYEE
Sbjct: 424 QEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEE 483
Query: 477 RVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQE 536
RVQ V +A+ L AE Y+DI+R+ A++D+V+R W L L+ ARR RLE NL LQK+FQE
Sbjct: 484 RVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQE 543
Query: 537 MLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFAT 596
M+Y++DWM+EM+ +LS++ G+HL+ +DLLQKH L+E DI Q+ERV +NA+A +F +
Sbjct: 544 MVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRF-S 602
Query: 597 DGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIRE 656
+GY+PCDPQVI +RV H+ C EL + AA RRA LE SR LW E+ E E W R+
Sbjct: 603 QLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARD 662
Query: 657 KEKILSSDDYG---------------KDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEG 701
KE++L + G DL+S RLL++H+ + E+ GR +QA++ G
Sbjct: 663 KERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCG 722
Query: 702 EDMIAEEHF---GSEKIR-----ERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADA 753
E+++A G++ + ER R +W LE+ +A R++RL+EA LHQF AD
Sbjct: 723 EELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADL 782
Query: 754 DDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQE 813
D + W+ D ++ ++ D GHDE S++ L ++H+ + E+ +R + L Q + L
Sbjct: 783 DGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGA 842
Query: 814 HAESPDV---RGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQ 870
P V + R+ E+ + EV E+ LR+Q L+D LA+Y+MF E ACELWI EKEQ
Sbjct: 843 SGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQ 902
Query: 871 WLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ 930
WL +M++P+ L+D+EV+QHRFESL+ EMN+ RV VN ++L+ GHPS E+++ Q
Sbjct: 903 WLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQ 962
Query: 931 DKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAG 990
D LN+RW++ ELV+++K+ + + L ++N+ LE E ++ +REK + +ES G
Sbjct: 963 DHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG---- 1018
Query: 991 VMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTT 1050
ALQ +L+G+E L A+E + + L +EA L P QA + E+ W + +
Sbjct: 1019 --ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASA 1076
Query: 1051 LKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASED--MPNTLTEAEKLLTQHENIK 1108
+ ++ A +LQ+FL DLD F WL R Q A + +PN+L EA+ LL +H +K
Sbjct: 1077 AQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALK 1136
Query: 1109 NEIDNYEEDYQKMRDMGE--MVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLS 1166
E+D EEDY ++ E + G + L + L L+ GW++L +WE R+ L
Sbjct: 1137 EEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALV 1196
Query: 1167 QSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKIN 1226
Q+H YQ FLRD +QA L NQE L+ E+P T+E E A+K+ DF+TTM+ +++K+
Sbjct: 1197 QAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQ 1256
Query: 1227 AVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQE 1286
V+ L+ GNI ++ QE V + +++++N+ A + + +L D +LQ FL+DC E
Sbjct: 1257 VAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHE 1316
Query: 1287 LSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPE 1346
L WI+EKML A+D + ++ LH +WL+HQAFMAELA NKEWL+KIE+EG QL+ EKPE
Sbjct: 1317 LDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPE 1376
Query: 1347 TEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSD 1406
A V++KL + + W LESTTQ KA++LF+A+KA+ QS A+LDK L +ESQ+Q
Sbjct: 1377 LAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDV 1436
Query: 1407 DYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTK 1466
D G DL +VN LKK Q +E+Q+E +E+ ELQ+Q AL E S + V ++ V +
Sbjct: 1437 DPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGER 1496
Query: 1467 FMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKK 1526
+ LLEPL ER+ LLASKE+HQ D++DE+ WV ER+PLA T+ G+ LQ VQ IKK
Sbjct: 1497 LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKK 1556
Query: 1527 NQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHR 1586
NQ L++EIQ H PR++++ ER+ + S AEA+R+ L L+ W L E E+R +
Sbjct: 1557 NQGLRREIQAHGPRLEEVLERA-GALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQ 1615
Query: 1587 RLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAE 1646
L+ A + +QYYFD AE EAW+ EQEL MMSE+K KDEQS + +LKKH LEQ VE+Y E
Sbjct: 1616 VLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEE 1675
Query: 1647 TVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNRE 1706
++ QLS+ RAL+ HP+SE+IS RQS+VD+LY LK+L EERR L++++ L+QL+R+
Sbjct: 1676 SIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQ 1735
Query: 1707 VDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELI 1766
V +LE WIAE+EVVAGS ELGQD+EHV++LQE+F EFA +TG G+ER+ VN + DELI
Sbjct: 1736 VSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELI 1795
Query: 1767 NSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHK 1826
GH+ AAT+AEWKDGLNEAWA+LLEL+ TR Q+LAAS ELHKF+ DA+E+ G+I++K +
Sbjct: 1796 ECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRR 1855
Query: 1827 KLPE--ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQK 1884
+LP + + ++QR FEHD+Q L +QVRQLQE AA+L+ YAG+ A+ I
Sbjct: 1856 RLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIAS 1915
Query: 1885 RENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVS 1944
RE EVL+ WK LL ACE R+ + T D RF S VRDL+ WM+ + QI A +KPRDVS
Sbjct: 1916 REQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVS 1975
Query: 1945 SVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMID 2004
SVE+LMN HQG+K E++AR TTC ELG+SLL K ++EI+ +L +L +++E+ +
Sbjct: 1976 SVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSE 2035
Query: 2005 KWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEK 2064
KW+ WEWL+ +LEVHQF+++A VA+AWL QEP L SRE+G SVDEVE+LI+RHEAF K
Sbjct: 2036 KWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRK 2095
Query: 2065 SAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSP 2103
+AA W+ERFS+L RLTT+E ++ E+ ++PP+P
Sbjct: 2096 AAAAWEERFSSLRRLTTIEKIKA-------EQSKQPPTP 2127
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 929 bits (2401), Expect = 0.0
Identities = 616/2134 (28%), Positives = 1062/2134 (49%), Gaps = 89/2134 (4%)
Query: 40 FERSRIKALADEREAVQKKTFTKWVNS--HLARVSCRITDLYTDLRDGRMLIKLLEVLSG 97
+E I+ L +Q+KTFTKW+N+ + +I +LYT+L DG L++LLE++SG
Sbjct: 5 YETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISG 64
Query: 98 ERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRF 157
E LP P++GR+R+H LEN +AL FL+ +V + +G +IVDG+ L LGLIW IILRF
Sbjct: 65 EALPPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIILRF 123
Query: 158 QIQDISVETED---NKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHK 214
QI IS++ E+ + S K+ALL+WCQ KTA Y NVNI +F+ SW DG+ FNALIH
Sbjct: 124 QISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHA 183
Query: 215 HRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYY 274
HRPDL+D+ L+ +NL AF +AEQ LG+ +LLDPED++ PDE+SI+TYV YY
Sbjct: 184 HRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYY 243
Query: 275 HYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSL 334
HY S++ +R+ K+L ETE + +YE L +DLL WI + + L R F +SL
Sbjct: 244 HYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSL 303
Query: 335 VGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINK 394
++Q L AF +RT EKPP+ ++G E LLF +Q+ ++A N++ ++P EG ++++++
Sbjct: 304 PAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQ 363
Query: 395 AWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNF-GFD 453
W LE AE R AL+ L++ ++LE LARRF KAA+RE++L + ++++ Q
Sbjct: 364 CWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPAS 423
Query: 454 LPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYL 513
L VEAA ++ +E I E R QA+ +A L E YH + R++ V W+ L
Sbjct: 424 LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
Query: 514 LELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLV 573
L+ L+ +R+++ + + QE+ ++E++ S G+ L V +LLQ+H L+
Sbjct: 484 LQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLL 543
Query: 574 EADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRAR 633
EA + V + AQ+ A + + +V++ + + Q L L RRA
Sbjct: 544 EAQVSAHGAHVSHL---AQQTA-ELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRAL 599
Query: 634 LEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGH 693
LE++ + +F EEE W++E + + + G+DL+ + L KH+A E E+
Sbjct: 600 LEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAV 659
Query: 694 FEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADA 753
++ G D+ A ER ++ W L+ R RL+ A L+ Q+ ADA
Sbjct: 660 CVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADA 719
Query: 754 DDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL--- 810
+ +W+ + + + G D+ + ++L+++H + + + L L EQ A
Sbjct: 720 AEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASAR 779
Query: 811 ------------PQEHAESPDVRGRLS-------------------------------GI 827
P E +P S +
Sbjct: 780 ASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHL 839
Query: 828 EERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVI 887
+ Y+ + L +LR+ L++ +AL+ S +LW++++ L +Q + + LEV+
Sbjct: 840 SQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQ--PQADTLEVM 897
Query: 888 QHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRK 947
Q ++E+ + A V+ A QL + +I+ QQ++L+ RW Q L K
Sbjct: 898 QLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREK 957
Query: 948 KDALLSALSIQNYHLECNETKSWIREKTKVIESTQ-DLGNDLAGVMALQRKLTGMERDLV 1006
L ++ + ++ EC T+ +R+ +E+ Q D + L +K T +
Sbjct: 958 AVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKT------L 1011
Query: 1007 AIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQ 1066
+E ++ LQ K+E ++Q + ++ + + ++++ + R E Q
Sbjct: 1012 VLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQS 1071
Query: 1067 FLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGE 1126
FL++ W Q + S+++ + A++LL +H+++ EI ++E Q++ +
Sbjct: 1072 FLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQ 1131
Query: 1127 -MVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFL 1185
M D+Q + L+ L EL +WE RQ L + Q+F R+ A
Sbjct: 1132 PMAALDCPDSQE--VPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATC 1189
Query: 1186 NNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDR 1245
N + L + + A + +++ +F + + A+ G +LV + +
Sbjct: 1190 ANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHT 1249
Query: 1246 IQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDE 1305
++E++ SI + + + + + +L + LQ++ QD EL W+ EK L A
Sbjct: 1250 VREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGA 1309
Query: 1306 ARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVL 1365
RN+ +H+A +EL + + ++ +++ G +L+S +P + ++ +L GL WE L
Sbjct: 1310 RRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
Query: 1366 ESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQML 1425
+ L A + E + D + L LE +QS + G+DL S L K+ Q L
Sbjct: 1370 NRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQL 1429
Query: 1426 ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLE-PLNERKHNLLAS 1484
E++ ++ L S A ++ +E + +ELL+ L R L AS
Sbjct: 1430 ESESRTLAAKMAALASMAHGMAASPAILEETQK-----HLRRLELLQGHLAIRGLQLQAS 1484
Query: 1485 KEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDI 1544
E+HQF E+ WV E MP + T + L Q L +K++ LQ E++ HQ ++ +
Sbjct: 1485 VELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRV 1544
Query: 1545 FERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEA 1604
+++ S A+ I ++ +L+ W L E R + L++A QQY+ D +E
Sbjct: 1545 LSSGRSLAA-SGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSEL 1603
Query: 1605 EAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHP 1664
E W+ E+ + S + +DE + + ++ KHQ L++ + Y ++ +L +T++ L P
Sbjct: 1604 EGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVP 1663
Query: 1665 ESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIA-EREVVAGS 1723
E +R+ Q ++ + L++LA R +L+ RL + RE +DL+ W+A +++ G
Sbjct: 1664 EQQRVV--QERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGG 1721
Query: 1724 HELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGL 1783
LG+D EH L +F +F +G +RV LA+ L+ GHS + + + L
Sbjct: 1722 ESLGEDPEHALHLCTKFAKFQHQV-EMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDL 1780
Query: 1784 NEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQ 1843
AW++L EL R L + + + D E+ ++Q+K LP + RD +E
Sbjct: 1781 QTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQL 1840
Query: 1844 RMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESR 1903
R H E ++ Q+++L E A R+Q G +A +Q+R+ V +AW L E R
Sbjct: 1841 RSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQR 1900
Query: 1904 RVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDAR 1963
R +L RF + VRD W V + ++ +E ++ SS L ++ HQ ++AE++AR
Sbjct: 1901 RAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAR 1960
Query: 1964 NDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFS 2023
+ +LG+ L ++E++E+L L ++R ++ W + E L+ + F
Sbjct: 1961 EKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFL 2020
Query: 2024 RDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL-ERLTTL 2082
R+ E L QE L + +G SV+EVE+LI++HE F K D++ +AL ERL TL
Sbjct: 2021 RECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTL 2080
Query: 2083 ELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQ 2116
V R R P + +V E AES+
Sbjct: 2081 RRPRV--------RDRLPILLQRRMRVKELAESR 2106
Score = 553 bits (1425), Expect = e-157
Identities = 471/1960 (24%), Positives = 874/1960 (44%), Gaps = 144/1960 (7%)
Query: 391 DINKAWERLEKAEHERELALRNE----LIRQEKLEQLARRFDRKAAMRETWLSENQRLVS 446
D+ AW L + R ALR+ + ++ LE L + ++ ++
Sbjct: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825
Query: 447 QDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELE----AENYHDIKRITAR 502
+N DL +EA + H+ +E ++ E ++Q ++ A ++ H +++ R
Sbjct: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQ---R 1882
Query: 503 KDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLG 562
+ V + W L + RR +LE L + + W ++ + ++ +
Sbjct: 1883 QQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSS 1942
Query: 563 VEDLLQKHTLVEADIGIQAER-VRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQ 621
L H + A++ + + + Q G K +++ + ++
Sbjct: 1943 GPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE-----VQEELRALQDQRD 1997
Query: 622 ELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHR 681
++ Q A ++ RL+ ++ F E E + +E L + G + V +L+ KH
Sbjct: 1998 QVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHE 2057
Query: 682 AFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLE 741
F ++ + E A++E + ++R+R+ + ++ +++L+ R L
Sbjct: 2058 VFLKVLTAQDKK-EAALRERLKTLRRP-----RVRDRLPILLQRRMRVKELAESRGHALH 2111
Query: 742 EASLLHQFQADA----DDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYR 797
+ L+ F A D I AW + + V D+ D+ + KH+ E+ +
Sbjct: 2112 ASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL-RDKLKP---LLKHQAFEAEVQAHE 2167
Query: 798 PTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFS 856
+ ++ ++ AL Q H + +V RL G+ + ++++ + LR Q L+D +
Sbjct: 2168 EVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQ 2227
Query: 857 EADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLM 916
D E WI EKE +N + + LE ++ R A + I+ +
Sbjct: 2228 RVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSL 2287
Query: 917 HSGHPSEKEIKA---QQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIRE 973
+ +E+K ++ +LN RW+ F + R + L AL I E + I+E
Sbjct: 2288 QLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQE 2347
Query: 974 KTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAI 1033
K +I++ D G DL V L RK +ER++ I+A++ L++E +L P+ A +
Sbjct: 2348 KEALIQAL-DCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
Query: 1034 LSRLAEISDVWEEMKTTL-KNREA--SLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDM 1090
R E+++ W ++++ K REA +L +A KLQ L++L R + + +
Sbjct: 2407 RHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL---LVSAQRLRAQMDTSPA 2463
Query: 1091 PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGE-MVTQGQTDAQYMFLRQRLQALDT 1149
P + EA ++L +H+ K E+D++ + R G+ ++T G + +RQ L L+
Sbjct: 2464 PRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSD--IRQVLAGLEQ 2521
Query: 1150 GWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIK 1209
+ L W+ Q L Q+ Q FL ++ E +L ++E LA + L E +
Sbjct: 2522 ELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW 2581
Query: 1210 KQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLM 1269
K + ++ KI+A+ T R L G+ + + ++ R A
Sbjct: 2582 KHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRH 2641
Query: 1270 RLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEW 1329
RL++ R LQ FLQD QE++ W+ EK L A + + L ++ K Q F AEL ++
Sbjct: 2642 RLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQ 2701
Query: 1330 LDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSC 1389
++++EG +L+ ++E+L L +W L+ +Q K +L A +A +S
Sbjct: 2702 QQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSM 2761
Query: 1390 ADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQE 1449
+L+ WL +E ++++ G+ L V LL Q+ LE ++ + ++ E L QAQA +E
Sbjct: 2762 EELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVRE 2821
Query: 1450 GKS-TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLA 1508
G +V+ + + +F L EPL ER+ L A + +F RD ++E+ WV E++PLA
Sbjct: 2822 GHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLA 2881
Query: 1509 TSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLA 1568
+ D+G +L V+ L +++Q L+ E+ H+ + +V + +A + R+
Sbjct: 2882 AAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLV-QAGHFAAHEVAARVQ 2940
Query: 1569 DLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAV 1628
L++ L E +R L++A AQQ+ + EA +W++E+ + SE+ ++
Sbjct: 2941 QLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQ 3000
Query: 1629 SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAE 1688
++L++ + ++ +E ++ + +L +T+ L + +PES ++ + V + +A L AE
Sbjct: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAE 3060
Query: 1689 ERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTG 1748
R L E+ +L QL RE L+ W+ + A S + GQD E V +L+E+F F ++
Sbjct: 3061 ARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQ 3120
Query: 1749 NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELH 1808
++GQ +V + LA L I + + AW L + I RT+ LAA++E+H
Sbjct: 3121 SLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVH 3180
Query: 1809 KFYHDAKEIFGRIQDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDA 1867
F A E+ GR+Q+K + E+ G ++V TLQ+ H E +++A+ +V +LQ +A
Sbjct: 3181 SFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA 3240
Query: 1868 AR---LQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLM 1924
R L A G A +V EAW +L + R L F ++L+
Sbjct: 3241 CRLGQLHPAAPGGLA--------KVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELL 3292
Query: 1925 LWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYA 1984
W ++ ++E DV+ E L+ H+ + EI + G+ L+ H+
Sbjct: 3293 AWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFM 3352
Query: 1985 SEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSRE 2044
S E+ E L +L + +E+ + W RW+ + + + AEAWL E L +
Sbjct: 3353 SAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPD 3412
Query: 2045 IGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPE 2104
G SV +VE L+ RH+ EK A +E+F+ ++++ + E+E +P +
Sbjct: 3413 YGHSVSDVELLLHRHQDLEKLLAAQEEKFA-----------QMQKTEMEQELLLQPQELK 3461
Query: 2105 PSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKES 2164
P S + + QW S GL A+ +AET D +++
Sbjct: 3462 PGRAGS--SLTSFQWRPS-----GHQGLGAQ-----LAETRD--------------PQDA 3495
Query: 2165 SPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKASSRSWHN 2224
P+ + K L LP Q + S+ W +
Sbjct: 3496 KGTPTMEGSLEFKQHL-------LPGGRQPSSSS-----------------------WDS 3525
Query: 2225 VYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNE 2284
+ + + D + AA + S + L A CE +KH F LRL G E
Sbjct: 3526 CRGNLQGSSLSLFLDERMAAEKVA--SIALLDLTGARCERLRGRHGRKHTFSLRLTSGAE 3583
Query: 2285 YLFQAKDDEEMNTWIQAISSAISSDKHEVSASTQSTPASS 2324
LF A +E+ +W +A+ S + +S ++ P SS
Sbjct: 3584 ILFAAPSEEQAESWWRALGSTAA---QSLSPKLKAKPVSS 3620
Score = 436 bits (1121), Expect = e-121
Identities = 394/1832 (21%), Positives = 794/1832 (43%), Gaps = 89/1832 (4%)
Query: 389 ISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQD 448
+ I W RL+ +R L L QE + +A W+ E + + +
Sbjct: 1254 LQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQ--------WMEEKGLMAAHE 1305
Query: 449 NFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIR 508
G ++ K+HEA E+++ A V+A+ V REL + + I R +
Sbjct: 1306 PSGARRNILQTL-KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRS 1364
Query: 509 LWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQ 568
WE L + R L+ +++ +++ + +++++ + S + G+ L + L +
Sbjct: 1365 KWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQK 1424
Query: 569 KHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ-LA 627
+H +E++ A ++ + + A A P ++ + H+ EL Q
Sbjct: 1425 RHQQLESESRTLAAKMAALASMAHGMAAS--------PAILEETQKHLRRL--ELLQGHL 1474
Query: 628 AERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEM 687
A R +L+ S L +F E W+ E S Y + L L KH+ + E+
Sbjct: 1475 AIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEV 1534
Query: 688 SGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLH 747
G ++ + G + A H ++ I E+ + WA LE+ R + L++A
Sbjct: 1535 KAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQ 1594
Query: 748 QFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQA 807
Q+ D +++ W+ + +VSS D G DE +T L+ KH+ + EE+A Y +++ L + A
Sbjct: 1595 QYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTA 1654
Query: 808 SALPQEHAESPDVRGRLSGIEERYKE----VAELTRLRKQALQDTLALYKMFSEADACEL 863
L P+V + ++ER +E + EL R + L+ TL L++ EA+ +
Sbjct: 1655 QTL-----TGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQG 1709
Query: 864 WI-DEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS 922
W+ +K+ + E E + +F + ++ + RVA +A L+ GH +
Sbjct: 1710 WLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSA 1769
Query: 923 EKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQ 982
++ +Q L T WS+ EL + AL + H + E + ++EK + +
Sbjct: 1770 GPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPN-- 1827
Query: 983 DLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHP-DQAQAILSRLAEIS 1041
++ DL G+ A R G+ER+LV E +L +L + A +++ P QA A+ R ++
Sbjct: 1828 NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVT 1887
Query: 1042 DVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLL 1101
W ++ ++ R A L A L +F + D+ SW +R + + E+ + L
Sbjct: 1888 QAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKL 1947
Query: 1102 TQHENIKNEIDNYEEDYQKMRDMGE--MVTQGQTDAQYMFLRQRLQALDTGWNELHKMWE 1159
+ H+ ++ E++ E+ +Q+ +G+ ++ G + +++ L+AL +++++ W
Sbjct: 1948 SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWA 2004
Query: 1160 NRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMD 1219
+Q L Q FLR+ + E L QE L + + +++E E I+K E F+ +
Sbjct: 2005 RKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLT 2064
Query: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1279
A ++K A+ E + L R+++++ + R + +E A L + +
Sbjct: 2065 AQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMAS 2118
Query: 1280 FLQDCQELSLWINE-KMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGM 1338
F Q + WI + + + R+ LKHQAF AE+ +++E + + K+G
Sbjct: 2119 FTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGE 2178
Query: 1339 QLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHG 1398
L+++ V ++L GL K WE L + Q L D F Q + W+
Sbjct: 2179 ALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQE 2238
Query: 1399 LESQIQSDDYGKDLTSVNILLKKQQMLENQM------EVRKKEIEELQSQAQALSQEGKS 1452
E ++ D G+DL L ++ + + + I +L Q + +++ +
Sbjct: 2239 KEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLK--NRDPEE 2296
Query: 1453 TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTD 1512
+ +R + ++ L + L + EIH +R++++ + E+ L + D
Sbjct: 2297 VKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALD 2356
Query: 1513 HGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQ 1572
G +L++VQ L++K++ L++E+ Q +++ + ER + S +A +R R ++ +
Sbjct: 2357 CGKDLESVQRLLRKHEELEREVHPIQAQVESL-EREVGRLCQRSPEAAHGLRHRQQEVAE 2415
Query: 1573 LWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQEL--YMMSEEKAKDEQSAVSM 1630
W L +KR L+ H+AQ+ A E +S Q L M + + A M
Sbjct: 2416 SWWQLRSRAQKRREALDALHQAQK--LQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRM 2473
Query: 1631 LKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEER 1690
L++HQ + ++ + +++ T + L+ HP S I + +++ + L+ +E
Sbjct: 2474 LEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEH 2533
Query: 1691 RGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI 1750
+ +L + L V+ +E+W+ +E S L + L + + D +
Sbjct: 2534 QLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDL-EV 2592
Query: 1751 GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKF 1810
++ + A L GH +A + + L TR L +L F
Sbjct: 2593 QAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAF 2652
Query: 1811 YHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAAR- 1869
D++E+ +++K+ EE D + + F+ ++ A Q ++LQ + R
Sbjct: 2653 LQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRL 2712
Query: 1870 LQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMED 1929
LQ + +A IQ+R E+ W L D + + +L + R + +L W+E
Sbjct: 2713 LQGGHPASEA--IQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEP 2770
Query: 1930 VIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIK 1989
+ ++ A + + V L+ + ++A +D + + ++ + H +++++
Sbjct: 2771 IEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVE 2830
Query: 1990 EKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSV 2049
E+ +L ++ K + + ++R L + +F RDA AW+ + P ++++ GQS+
Sbjct: 2831 EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSL 2890
Query: 2050 DEVEKLIKRHEAFEKSAATWDE----------------RFSALERLTTLELLEVRRQQEE 2093
V L ++H+ E ++ + F+A E ++ LE
Sbjct: 2891 SAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLR 2950
Query: 2094 EERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETV-DTSEMVN 2152
E RR + ++A+ QQ+ T E + AE+G +E + ++E
Sbjct: 2951 AEAARR-------RLLLQQAQEAQQFLT---ELLEAGSWLAERGHVLDSEDMGHSAEATQ 3000
Query: 2153 GATEQRTSSKESSPIPSPTSDRKAKTALPAQS 2184
+ ++K SP +R +TA +S
Sbjct: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLES 3032
Score = 392 bits (1006), Expect = e-108
Identities = 381/1789 (21%), Positives = 759/1789 (42%), Gaps = 75/1789 (4%)
Query: 309 SLASDLLEWIE-QTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLF 367
S +L W+E QT+++ + A++L +Q + + F T V K + E L
Sbjct: 868 SSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQL-- 925
Query: 368 TIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRF 427
+ + N+ ++ +E ++++ W +LE + E+ + L + + E L
Sbjct: 926 --RQRYPGNSTQIQRQQE-----ELSQRWGQLEALKREKAVQLAHSV---EVCSFLQECG 975
Query: 428 DRKAAMRETWLSEN--QRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVA 485
+ +R+ L Q S+D A++ A KK +E RV + +V
Sbjct: 976 PTQVQLRDVLLQLEALQPGSSEDT----CHALQLAQKKTLVLE-------RRVHFLQSVV 1024
Query: 486 RELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMD 545
++E Y + + + + + + L + + E + R +R Q QE ++ W +
Sbjct: 1025 VKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAE 1084
Query: 546 EMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPC- 604
++ + S++ + + LL++H + +I + ER++ ++A +Q A C
Sbjct: 1085 SVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAA-----LDCP 1139
Query: 605 DPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSD 664
D Q + + + + QEL L +R+ L+E L KF E+ + L D
Sbjct: 1140 DSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLD 1199
Query: 665 DYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIRE 724
+ G+D+ + LL +HR F +S E GE ++ +H + +RE++ I+
Sbjct: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
Query: 725 QWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVK 784
QW L+ S R+++L + L +++ D ++ WM + + + G Q+L K
Sbjct: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-K 1318
Query: 785 KHKDVAEEIANYRPTLDTLHEQA-SALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQ 843
+H+ E+ R ++ L + L + D++ RL G+ +++ + R
Sbjct: 1319 RHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGD 1378
Query: 844 ALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQAS 903
LQ ++ + + +++ E L + + + L + +Q R + LE E A+
Sbjct: 1379 ELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAA 1438
Query: 904 RVAVVNQIARQLMHSGHPSE------KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSI 957
++A + +A + S E + ++ Q L R Q + V+ + LS + +
Sbjct: 1439 KMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMEL 1498
Query: 958 QNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQK 1017
SW+ E S L G +L RK ++ ++ A + ++ +
Sbjct: 1499 -----------SWVAEHMP-HGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLS 1546
Query: 1018 EAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSW 1077
L + QAQ I+ + E+ W E++ + R L +A QQ+ D+ + + W
Sbjct: 1547 SGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGW 1606
Query: 1078 LSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQY 1137
+ + ++S D +L+ +H+ ++ E+ Y +++ + +T + Q
Sbjct: 1607 VEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQ 1666
Query: 1138 MFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE- 1196
+++RL+ L ++ R L + +FLR+ + + +L +Q+ E
Sbjct: 1667 RVVQERLR---EQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGES 1723
Query: 1197 MPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDR 1256
+ E A K F ++ +++ A L+ G+ ++++ +
Sbjct: 1724 LGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTA 1783
Query: 1257 HRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKH 1316
+ E L+D + +D E+ + EK + + + L ++ H
Sbjct: 1784 WSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSH 1843
Query: 1317 QAFMAELASNKEWLDK-IEKEG-MQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQ 1374
Q EL + L + +E G +Q + P+ A V+++ + + W VL+ + +
Sbjct: 1844 QGLERELVGTERQLQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRA 1902
Query: 1375 RLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKK 1434
+L A F + D W + +Q ++ ++ +S + L Q L ++E R+K
Sbjct: 1903 QLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREK 1962
Query: 1435 EIEE-LQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRD 1493
++ Q QAL G T EV + +Q + ++ + ++ L A ++ F R+
Sbjct: 1963 LWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRE 2022
Query: 1494 VE--DEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNI 1551
+EIL + + L TS G +++ V+ LI+K++ K + + + ER +
Sbjct: 2023 CGRLEEIL-AAQEVSLKTSA-LGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLK-- 2078
Query: 1552 VTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQ 1611
+L +R RL L Q + E E R L + + A +AE W+
Sbjct: 2079 -----TLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAW 2133
Query: 1612 ELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISM 1671
+ D + + L KHQ E V+ + E + ++K AL+A SHP + +S
Sbjct: 2134 AQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQ 2193
Query: 1672 RQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYE 1731
R + K + L+ R +L++R + + VD E WI E+EV +LGQD E
Sbjct: 2194 RLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLE 2253
Query: 1732 HVTMLQERFREFARDTG--NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWAD 1789
H L+ R REF ++ +G + +++ L+ +L N + I + + LN WA
Sbjct: 2254 HCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWAS 2313
Query: 1790 LLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE-ELGRDQNTVETLQRMHTT 1848
+ Q L + E+H + + RIQ+K + + G+D +V+ L R H
Sbjct: 2314 FHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEE 2373
Query: 1849 FEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLV 1908
E ++ + QV L+ + RL + + A ++ R+ EV E+W L + RR L
Sbjct: 2374 LEREVHPIQAQVESLEREVGRL-CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALD 2432
Query: 1909 DTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFT 1968
+ +M+++L++ + + Q++ PR ++ HQ KAE+D+ DS +
Sbjct: 2433 ALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSIS 2492
Query: 1969 TCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASV 2028
G+ LL H S +I++ L L ++ + W++ L+ LE+ F
Sbjct: 2493 LARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK 2552
Query: 2029 AEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALE 2077
E WL +E L+S + + +E L+ +H+ E + SALE
Sbjct: 2553 MERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601
Score = 301 bits (770), Expect = 7e-81
Identities = 366/1758 (20%), Positives = 702/1758 (39%), Gaps = 137/1758 (7%)
Query: 416 RQEKLEQLARR--FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAA 473
R+ LEQ +R F R E WL E + V G DL + A +KH+A+E ++
Sbjct: 596 RRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHR 655
Query: 474 YEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKI 533
++ +V R+L A R + V W+ L + R RL+ L + +
Sbjct: 656 HQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQY 715
Query: 534 FQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVE-------ADIGIQAERVRG 586
F + W+ E + + G+ E LL++H +E A++ E+ R
Sbjct: 716 FADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRA 775
Query: 587 VNASAQKFATD-------------------------GEGYKPC---------DPQVIRDR 612
+A A F + G+ +K DP I
Sbjct: 776 ASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQT 835
Query: 613 VAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTS 672
H+ Y+ L LA RRARLEE+ L+ F E + W+ ++ +L D
Sbjct: 836 QDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLE 895
Query: 673 VMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQL 732
VM+L K+ F ++ G + + E + S +I+ + + ++W LE L
Sbjct: 896 VMQL--KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEAL 953
Query: 733 SAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQS--LVKKHKDVA 790
+ +L + + F + + D+L + + G E + + L +K V
Sbjct: 954 KREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVL 1013
Query: 791 EEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA 850
E ++ ++ E+ +AES ++G++ ++ K+V E R + +T A
Sbjct: 1014 ERRVHFLQSVVVKVEEPG-----YAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQA 1068
Query: 851 LYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQ 910
E+ LW + + L + ++ + + + + L E++ R+ ++
Sbjct: 1069 RQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDA 1128
Query: 911 IARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLE------- 963
++ + P +E+ L + + + L ++++ L L +Q + E
Sbjct: 1129 QSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTAT 1188
Query: 964 CNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL- 1022
C ++W+ +LG D+ ++L ++ R L + + L+ EKL
Sbjct: 1189 CANHQAWLH--------LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV 1240
Query: 1023 ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQ 1082
+S+HP A + +L I W ++ + R L + +LQ++ +D+ + W+ +
Sbjct: 1241 QSQHP-AAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEE-K 1298
Query: 1083 TAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG-EMVTQ---GQTDAQYM 1138
+A+ + + L +HE ++E+ + ++ +G E++++ GQ D Q
Sbjct: 1299 GLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQ-- 1356
Query: 1139 FLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMP 1198
RLQ L + W L++ R + L Q+ +Q LR + A+ L E L +E
Sbjct: 1357 ---TRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETG 1413
Query: 1199 TTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHR 1258
L ++ K+ + + K+ A+ ++ G S I E+ +H
Sbjct: 1414 QDLRSSQRLQKRHQQLESESRTLAAKMAALAS-----MAHGMAASPAILEET----QKHL 1464
Query: 1259 KNRETASELL----MRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARN-LHSKW 1313
+ E L ++L+ + +L +F W+ E M SY E N S
Sbjct: 1465 RRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLH 1524
Query: 1314 LKHQAFMAELASNKEWLDKIEKEGMQL-ISEKPETEAVVKEKLTGLHKMWEVLESTTQTK 1372
KH+ E+ +++ + ++ G L S P+ + +V E+ L W LE + +
Sbjct: 1525 RKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIV-EQCQELEGHWAELERACEAR 1583
Query: 1373 AQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVR 1432
AQ L A + + ++L+ W+ + S DYG+D + L+ K Q L+ ++ +
Sbjct: 1584 AQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIY 1643
Query: 1433 KKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNE----RKHNLLASKEIH 1488
+EEL AQ L + EV ++ VQ + E L L E R L + +H
Sbjct: 1644 WSSMEELDQTAQTL-----TGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLH 1698
Query: 1489 QFNRDVEDEILWVGERMPLATSTDH-GHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFER 1547
+F R+ ED W+ + A + G + + L K Q +++ R+
Sbjct: 1699 EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLL 1758
Query: 1548 SQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAW 1607
+++++ S + +RQR DL+ W L E T+ R L + + + D E
Sbjct: 1759 AESLLERGHS-AGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ 1817
Query: 1608 MSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTS-RALVADSHPES 1666
+ E+ + A+D + L+ HQ LE+ + + +L +T+ R P++
Sbjct: 1818 VQEKAT-SLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQA 1876
Query: 1667 ERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIA----------- 1715
+ RQ V + +A L+ E+RR +L+ L + V D W A
Sbjct: 1877 HAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEES 1936
Query: 1716 EREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAAT 1775
+E +G +L L+ R + + + T +GQ+ + E+ +
Sbjct: 1937 SQEPSSGPLKLSAHQWLRAELEAREKLWQQAT-QLGQQALLAAGTPTKEV----QEELRA 1991
Query: 1776 IAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRD 1835
+ + +D + + WA E + Q E + +EI + K LG
Sbjct: 1992 LQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRL----EEILAAQEVSLK--TSALGSS 2045
Query: 1836 QNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKS 1895
VE L R H F + A + L+E L+ D+ + +R V E
Sbjct: 2046 VEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKE---- 2101
Query: 1896 LLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQG 1955
ESR L + F W++ +Q++ P D+ + HQ
Sbjct: 2102 ---LAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQA 2158
Query: 1956 IKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRL 2015
+AE+ A + T+ + G++LLA+ H + E+ ++L L + +++ R + L
Sbjct: 2159 FEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELED 2218
Query: 2016 ILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSA 2075
+F + +AEAW+ +E ++ ++GQ ++ +L +R F ++A +
Sbjct: 2219 RRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDAC 2278
Query: 2076 LERLTTLELLEVRRQQEE 2093
+ ++ L L R EE
Sbjct: 2279 IRSISDLSLQLKNRDPEE 2296
Score = 168 bits (425), Expect = 7e-41
Identities = 193/930 (20%), Positives = 370/930 (39%), Gaps = 104/930 (11%)
Query: 1362 WEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKK 1421
W+ L Q + +++ D Q L L+ +S G+ L V LL++
Sbjct: 480 WQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQR 539
Query: 1422 QQMLENQMEVRKKEIEELQSQAQAL-SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHN 1480
+LE Q+ + L Q L S G S + + +K T+ L+ + R+
Sbjct: 540 HDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRAL 599
Query: 1481 LLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPR 1540
L + + +F R+ E+E W+ E + G +L + ++K++ L+ E+ HQ
Sbjct: 600 LEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAV 659
Query: 1541 IDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFD 1600
D+ R +++ + +R ++ W LL R RL+ A QY+ D
Sbjct: 660 CVDLVRRGRDLSARRPPTQPDP-GERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFAD 718
Query: 1601 AAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVA 1660
AAEA +W+ E+ + +D+ +A ++L++H LE+ + +A + +L + RA A
Sbjct: 719 AAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASA 778
Query: 1661 DS---------------------------HP------------------ESERISMRQSK 1675
+ HP + I Q
Sbjct: 779 RASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDH 838
Query: 1676 VDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTM 1735
+ + Y L+ LA+ RR +L+E LF +L+ W+ ++ V+ + + + +
Sbjct: 839 LSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL--QRVQPQADTLEV 896
Query: 1736 LQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELID 1795
+Q ++ F +G+ V+ A++L ++ I ++ L++ W L L
Sbjct: 897 MQLKYENFLTALA-VGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKR 955
Query: 1796 TRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE-ELGRDQNTVETLQ---RMHTTFEH 1851
+ LA S E+ F + +++D +L + G ++T LQ + E
Sbjct: 956 EKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLER 1015
Query: 1852 DIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTG 1911
+ L + V +++E YA ++ +Q + + K + + R R +T
Sbjct: 1016 RVHFLQSVVVKVEEPG------YA--ESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQ 1067
Query: 1912 DKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCI 1971
+ F + L+LW E V Q+ ++E DV+S + L+ HQ + EI +
Sbjct: 1068 ARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLD 1127
Query: 1972 ELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEA 2031
+ + A S+E+ L L ++ +E+ WE R +WL+ LE+ +F R+ A
Sbjct: 1128 AQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTA 1187
Query: 2032 WLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL--------------- 2076
+ +L +G+ V E L+++H F + +T R AL
Sbjct: 1188 TCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAA 1247
Query: 2077 ----ERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGL 2132
E+L +++ R Q E+R+R+ + + ++ QW KG +
Sbjct: 1248 HTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPS 1307
Query: 2133 PAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPART 2192
A + + T +R + ES + + R+ AL L R
Sbjct: 1308 GARRNILQ--------------TLKRHEAAESELL----ATRRHVEALQQVGRELLSRRP 1349
Query: 2193 --QETPSAQMEGFLNRKHEWEAHNKKASSR 2220
QE +++G + +WEA N+K + R
Sbjct: 1350 CGQEDIQTRLQGL---RSKWEALNRKMTER 1376
Score = 148 bits (374), Expect = 5e-35
Identities = 141/613 (23%), Positives = 263/613 (42%), Gaps = 26/613 (4%)
Query: 297 AIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQ-QLQAFNTYRTVEKPPK 355
A+E ++ K+ A + + W+++ + + + + SL V+ Q Q N +
Sbjct: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEA 2912
Query: 356 FTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKA-EHERELALRNEL 414
T V+L T ++A + + ++ ++LEKA H R A R L
Sbjct: 2913 LT-----RVVLGTGYKLVQAGHFAAH---------EVAARVQQLEKAMAHLRAEAARRRL 2958
Query: 415 IRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAY 474
+ Q+ E A++F + +WL+E ++ ++ G A +A ++ EA + D+ A+
Sbjct: 2959 LLQQAQE--AQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAF 3016
Query: 475 EERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIF 534
R++ + A LE+ + ++ A+ V LL AR L+ L L ++
Sbjct: 3017 SPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLE 3076
Query: 535 QEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKF 594
+E L + W+ SQDYG+ L GV+ L +K + +Q+ V A +
Sbjct: 3077 RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKE--VQSLGQAKVYALRKLA 3134
Query: 595 ATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWI 654
T G P + R + +E ++ L Q R L + + F AE +G +
Sbjct: 3135 GTLERGAPRRYPHIQAQR-SRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRM 3193
Query: 655 REKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK 714
+EK ++ +D G L+SV L +HR E E+ + E + + H +
Sbjct: 3194 QEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA-CRLGQLHPAAP- 3251
Query: 715 IRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGH 774
+ ++E WA L+ + R + L +A+ H F ++ AW + ++ SS ++
Sbjct: 3252 --GGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAE 3309
Query: 775 DEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERYKE 833
D + L+ +H+++ +EI R L ++ L H S +V L +E R +E
Sbjct: 3310 DVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQE 3369
Query: 834 VAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFES 893
+ E LR Q ++ L K+ + E W+ E L + D+E++ HR +
Sbjct: 3370 LEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQD 3429
Query: 894 LEPEMNNQASRVA 906
LE + Q + A
Sbjct: 3430 LEKLLAAQEEKFA 3442
>gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [Homo
sapiens]
Length = 678
Score = 672 bits (1734), Expect = 0.0
Identities = 346/654 (52%), Positives = 465/654 (71%), Gaps = 3/654 (0%)
Query: 1295 MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEK 1354
ML A+D + ++ LH +WL+HQAFMAELA NKEWL+KIE+EG QL+ EKPE A V++K
Sbjct: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
Query: 1355 LTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTS 1414
L + + W LESTTQ KA++LF+A+KA+ QS A+LDK L +ESQ+Q D G DL +
Sbjct: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
Query: 1415 VNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPL 1474
VN LKK Q +E+Q+E +E+ ELQ+Q AL E S + V ++ V + + LLEPL
Sbjct: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180
Query: 1475 NERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEI 1534
ER+ LLASKE+HQ D++DE+ WV ER+PLA T+ G+ LQ VQ IKKNQ L++EI
Sbjct: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
Query: 1535 QGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRA 1594
Q H PR++++ ER+ + S AEA+R+ L L+ W L E E+R + L+ A +
Sbjct: 241 QAHGPRLEEVLERA-GALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQV 299
Query: 1595 QQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKT 1654
+QYYFD AE EAW+ EQEL MMSE+K KDEQS + +LKKH LEQ VE+Y E++ QLS+
Sbjct: 300 EQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQ 359
Query: 1655 SRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWI 1714
RAL+ HP+SE+IS RQS+VD+LY LK+L EERR L++++ L+QL+R+V +LE WI
Sbjct: 360 CRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWI 419
Query: 1715 AEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAA 1774
AE+EVVAGS ELGQD+EHV++LQE+F EFA +TG G+ER+ VN + DELI GH+ AA
Sbjct: 420 AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA 479
Query: 1775 TIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE--EL 1832
T+AEWKDGLNEAWA+LLEL+ TR Q+LAAS ELHKF+ DA+E+ G+I++K ++LP
Sbjct: 480 TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTP 539
Query: 1833 GRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEA 1892
+ + ++QR FEHD+Q L +QVRQLQE AA+L+ YAG+ A+ I RE EVL+
Sbjct: 540 PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQG 599
Query: 1893 WKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSV 1946
WK LL ACE R+ + T D RF S VRDL+ WM+ + QI A +KPR SS+
Sbjct: 600 WKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSL 653
Score = 191 bits (485), Expect = 7e-48
Identities = 138/651 (21%), Positives = 285/651 (43%), Gaps = 8/651 (1%)
Query: 444 LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 503
L+++D D + +H+A ++A +E ++ + ++L E + +
Sbjct: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61
Query: 504 DNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGV 563
+ + W L +A+ ++L ++ Q + + M+ + D G L V
Sbjct: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121
Query: 564 EDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQEL 623
L+K +E+ + V + A + P +++ +R + L
Sbjct: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLE-----PASKELVGERQNAVGERLVRL 176
Query: 624 CQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAF 683
+ ERR L S+ L + ++ +E W++E+ + + G L +V + + K++
Sbjct: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 236
Query: 684 EDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA 743
E+ E+ ++ + + +E +R + ++ WA L + + R++ L+ A
Sbjct: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 296
Query: 744 SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTL 803
+ Q+ D +++AW+ + ++ S D G DE ST L+KKH + + + NY ++ L
Sbjct: 297 FQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQL 356
Query: 804 HEQASA-LPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACE 862
Q A L H +S + R S ++ Y + EL R+ AL+ LY++ + E
Sbjct: 357 SRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 416
Query: 863 LWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQA-SRVAVVNQIARQLMHSGHP 921
WI EKE + ++ + E + V+Q +F E R+A VNQ+ +L+ GH
Sbjct: 417 HWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHT 476
Query: 922 SEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIEST 981
+ + +D LN W++ EL+ + L ++ + + + E + I EK + +
Sbjct: 477 AAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 536
Query: 982 QDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHP-DQAQAILSRLAEI 1040
++QR L E DL + +++ LQ+ A +L + + + A+AI SR E+
Sbjct: 537 TTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEV 596
Query: 1041 SDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMP 1091
W+E+ + ++ + + +F + D SW+ + I + D P
Sbjct: 597 LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKP 647
Score = 133 bits (335), Expect = 2e-30
Identities = 135/638 (21%), Positives = 275/638 (43%), Gaps = 28/638 (4%)
Query: 785 KHKDVAEEIANYRPTLDTLHEQASALPQEHAE-SPDVRGRLSGIEERYKEVAELTRLRKQ 843
+H+ E+A + L+ + + L QE E + VR +L I + + E+ T+ + +
Sbjct: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
Query: 844 ALQDTLA---LYKMFSEADACELWIDEKEQWLNN----MQIPEKLEDLEVIQHRFESLEP 896
L + L + F+E D L ++ + Q ++ + +L+ L+ ++ + E
Sbjct: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
Query: 897 EMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQ-QDKLNTRWSQFRELVDRKKDALLSAL 955
E+ ++ A + P+ KE+ + Q+ + R + E + ++ LL++
Sbjct: 141 EVGELQAQTAALPL---------EPASKELVGERQNAVGERLVRLLEPLQERRRLLLASK 191
Query: 956 SIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL 1015
+ + ++ +W++E+ + T+ GN L V +K G+ R++ A +L ++
Sbjct: 192 ELHQVAHDLDDELAWVQERLPLAMQTER-GNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
Query: 1016 QKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQ 1075
+ A L S +A+A+ L ++ W ++ + R+ L A +++Q+ D+ + +
Sbjct: 251 LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVE 310
Query: 1076 SWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDY-QKMRDMGEMVTQGQTD 1134
+WL + + SED +LL +H ++ ++NYEE Q R ++ G D
Sbjct: 311 AWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370
Query: 1135 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH 1194
++ + RQ +D + L ++ E R+ L Q + Q R + E ++ +E V
Sbjct: 371 SEQISRRQ--SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGS 428
Query: 1195 TEMPTTLEGAEAAIKKQEDFMT-TMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSI 1253
E+ E +K +F + T A E++ AV + L+ G+ + + E D +
Sbjct: 429 PELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGL 488
Query: 1254 DDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEK--MLTAQDMSYDEARNLHS 1311
++ + E L +R+L KF D +EL I EK L + + S
Sbjct: 489 NEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS 548
Query: 1312 KWLKHQAFMAELASNKEWLDKIEKEGMQL--ISEKPETEAVVKEKLTGLHKMWEVLESTT 1369
+AF +L + ++++ QL + EA+ + L + W+ L S
Sbjct: 549 MQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVL-QGWKELLSAC 607
Query: 1370 QTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDD 1407
+ + A F DL W+ G+ SQI + D
Sbjct: 608 EDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645
Score = 100 bits (249), Expect = 2e-20
Identities = 119/500 (23%), Positives = 212/500 (42%), Gaps = 39/500 (7%)
Query: 287 GKRIGKVLDNAIETEKMI---EKYESLASDL---LEWIEQTIIILNNRKFANSLVGVQQQ 340
G+R+ ++L+ E +++ ++ +A DL L W+++ + + + N L VQQ
Sbjct: 170 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 229
Query: 341 LQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLE 400
++ R + LE +L + + + R G + + AW L
Sbjct: 230 IKKNQGLRREIQ----AHGPRLEEVLERAGALASLRSPEAEAVRRG--LEQLQSAWAGLR 283
Query: 401 KAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAA 460
+A R+ L ++EQ FD A E WL E + L+ ++ G D +
Sbjct: 284 EAAERRQQVLDAAF----QVEQYY--FD--VAEVEAWLGEQELLMMSEDKGKDEQSTLQL 335
Query: 461 TKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRAR 520
KKH +E + YEE + + R L + D ++I+ R+ V RL+ L EL R
Sbjct: 336 LKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEER 395
Query: 521 RQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQ 580
R LE L ++ +++ + W+ E +V+ S + G+ V L +K + ++ G+
Sbjct: 396 RVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMA 455
Query: 581 A-ERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRR 639
ER+ VN + G + + + + EL +L R L SR
Sbjct: 456 GRERLAAVNQMVDELIECGH----TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRE 511
Query: 640 LWKFFWEMAEEEGWIREKE----KILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFE 695
L KFF + E +G I EK ++ + + +S+ R L RAFE ++
Sbjct: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL---RAFEHDLQLLVSQVR 568
Query: 696 QAIKEGEDMIAEEHFG--SEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLH--QFQA 751
Q ++EG + + G +E I R + + W L LSA RL +S +F +
Sbjct: 569 Q-LQEGAAQLRTVYAGEHAEAIASREQEVLQGWKEL--LSACEDARLHVSSTADALRFHS 625
Query: 752 DADDIDAWMLDILKIVSSSD 771
D+ +WM I + ++D
Sbjct: 626 QVRDLLSWMDGIASQIGAAD 645
Score = 95.9 bits (237), Expect = 4e-19
Identities = 93/464 (20%), Positives = 200/464 (43%), Gaps = 22/464 (4%)
Query: 1633 KHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRG 1692
+HQ + E + ++ + + L+ + + + + ++ + +A L+ + +
Sbjct: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
Query: 1693 KLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTM-------LQERFREFAR 1745
+L E + QL + +L++ + E + G D V ++ + E+ R
Sbjct: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
Query: 1746 DTGNI-GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAAS 1804
+ G + Q + + EL+ E ++ + E LLE + R ++L AS
Sbjct: 141 EVGELQAQTAALPLEPASKELVG----------ERQNAVGERLVRLLEPLQERRRLLLAS 190
Query: 1805 YELHKFYHDAKEIFGRIQDKHK-KLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQL 1863
ELH+ HD + +Q++ + E G V+ + + +IQA G ++ ++
Sbjct: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
Query: 1864 QEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDL 1923
E A L A+ +A+ +++ ++ AW L +A E R+ L +++ V ++
Sbjct: 251 LERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309
Query: 1924 MLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHY 1983
W+ + + +++K +D S L+ H ++ ++ +S ++LL H
Sbjct: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369
Query: 1984 ASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSR 2043
SE+I + Q+ + + E+R L ++Q SR S E W+ +E S
Sbjct: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429
Query: 2044 EIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLE 2086
E+GQ + V L ++ F ++ ER +A+ ++ EL+E
Sbjct: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD-ELIE 472
Score = 85.5 bits (210), Expect = 6e-16
Identities = 79/385 (20%), Positives = 162/385 (42%), Gaps = 10/385 (2%)
Query: 1752 QERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFY 1811
+E ++ + +L+ AA++ + + + WA+L + + L + + +
Sbjct: 33 KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLV 92
Query: 1812 HDAKEIFGRIQDKHKKLPE-ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL 1870
E+ ++ +L + + G D TV + + + E ++ +V +LQ A L
Sbjct: 93 QSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAAL 152
Query: 1871 QAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDV 1930
A + + +R+N V E LL+ + RR L+ + + + + D + W+++
Sbjct: 153 PLEPASKEL--VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQER 210
Query: 1931 IRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKE 1990
+ E+ + +V+ + +QG++ EI A +E +L + + +E ++
Sbjct: 211 LPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRR 270
Query: 1991 KLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVD 2050
L QL + + E R + L +V Q+ D + EAWL QE + S + G+
Sbjct: 271 GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQ 330
Query: 2051 EVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVS 2110
+L+K+H E+ ++E + L R LLE+ E+ +R+ +
Sbjct: 331 STLQLLKKHLQLEQGVENYEESIAQLSR-QCRALLEMGHPDSEQISRRQSQVDRLYVALK 389
Query: 2111 EEAE------SQQQWDTSKGEQVSQ 2129
E E QQ W QVS+
Sbjct: 390 ELGEERRVALEQQYWLYQLSRQVSE 414
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 609 bits (1570), Expect = e-173
Identities = 402/1417 (28%), Positives = 707/1417 (49%), Gaps = 78/1417 (5%)
Query: 712 SEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 771
+E I+ER + +++ ++LS +R+++LE++ FQ DA++++ W+ + L+I S +
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
Query: 772 VGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEER 830
D + Q ++KH+ E+ + L E + + E H S +R RL + +
Sbjct: 72 Y-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 831 YKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHR 890
++ + E R + L L + E + WI++KE + + ++ + LE +EV+Q +
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 891 FESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDA 950
FE + +M RV VNQ A +L+ HP E+ IK +QD++N W + + L +++
Sbjct: 191 FEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK 250
Query: 951 LLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEA 1010
L A +Q ++ + +ET SWI+EK +++ S D G DLA V AL RK G+ERDL A+E
Sbjct: 251 LFGAAEVQRFNRDVDETISWIKEKEQLMAS-DDFGRDLASVQALLRKHEGLERDLAALED 309
Query: 1011 KLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRD 1070
K+ L EA++L+ HP A I + E+ WE+++T R A L ++ +LQ+FL D
Sbjct: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
Query: 1071 LDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQ 1130
D SW++ + I ++++ + + AE LL +H+ K EID +E+ ++ + G+ +
Sbjct: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
Query: 1131 GQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEY 1190
A +R++L L L ++WE R+ Q Q F RDT+Q + +++ QE
Sbjct: 430 AGHYASDE-VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
Query: 1191 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1250
L + ++ +L+ EA +KK EDF ++ A EEKI A+ E +L+ + + + + +
Sbjct: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
Query: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1310
D++ R E A +L D+ LQ+F +D EL W+NEKM TA D +Y + NL
Sbjct: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
Query: 1311 SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ 1370
K KHQAF AEL++N+ +D +EK G +LI + V ++ + +W+ L T+
Sbjct: 609 GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATE 668
Query: 1371 TKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQME 1430
K +L +AN+ + F ++ D++ WL+ +E + SDDYGKDLT+V L KK +LE +
Sbjct: 669 LKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA 728
Query: 1431 VRKKEIEELQSQAQALSQEGK-STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQ 1489
+ I+ + QA+ G + + K+ + ++ L EP+ RK L S + Q
Sbjct: 729 AHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
Query: 1490 FNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQ 1549
RDVEDE W+ E+ P+A ST+ G +L VQ L+KK+Q LQ EI GH+PRI + ++
Sbjct: 789 LFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG- 847
Query: 1550 NIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMS 1609
N + + +AE ++ +L +L Q W L + +R + LE++ +AQQY+ DA EAE+WM
Sbjct: 848 NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
Query: 1610 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669
E+E + S + KDE SA ++LKKH+ L + Y ++ L + +++ P +
Sbjct: 908 EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET 967
Query: 1670 SMRQSKVDKLYAGLKDLAEE--RRGKLDERHRLFQLNR--------EVDDLEQWIAEREV 1719
+L L D E+ R + + L LN EV+D + ++ V
Sbjct: 968 G------KELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYV 1021
Query: 1720 VAGSHELGQDYEHVTMLQERFREFARDTGNIG--QERVDTVNHLADELINSGHSDAATIA 1777
+ Q +L+E+ G+I QE++D + E A +++
Sbjct: 1022 --KKLDPAQSASRENLLEEQ--------GSIALRQEQIDNQTRITKE--------AGSVS 1063
Query: 1778 EWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQ 1836
+ E + LLEL + R +L S + + +A E+ I +K L EE+G D
Sbjct: 1064 LRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
Query: 1837 NTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQA-AYAGDKADDIQKRE--------- 1886
VE LQ+ F+ D++A ++++ + + A L++ ++ +Q++E
Sbjct: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
Query: 1887 -------------------------NEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVR 1921
E+ E W+SL E R L + RF
Sbjct: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
Query: 1922 DLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARK 1981
+ W+E+ + + D++SV+ L H+G + ++ A D + E + L+
Sbjct: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH 1303
Query: 1982 HYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLS 2041
++E+++EK +L + + + + R L ++ +F D +W+ G +S
Sbjct: 1304 PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
Query: 2042 SREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALER 2078
S E+ + V E L++RH+ F A E+
Sbjct: 1364 SDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
Score = 565 bits (1455), Expect = e-160
Identities = 403/1511 (26%), Positives = 737/1511 (48%), Gaps = 84/1511 (5%)
Query: 620 YQELCQLAAERRARLEESRRLWKFFWEMAEE-EGWIREKEKILSSDDYGKDLTSVMRLLS 678
Y +L+ RR +LE+S R ++FF AEE E WI+EK +I S ++Y KD T++ L
Sbjct: 26 YHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIASDENY-KDPTNLQGKLQ 83
Query: 679 KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 738
KH+AFE E+ SG + + G MI+E HF SE IR R++ + QW L + +
Sbjct: 84 KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGI 143
Query: 739 RLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 798
+L +A L Q+ + +D+ W+ D IV+S ++G D + L KK ++ ++A +
Sbjct: 144 KLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE 203
Query: 799 TLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 857
++ +++ A+ L QE H E ++ + + ++ + L R+ L + + +
Sbjct: 204 RVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRD 263
Query: 858 ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMH 917
D WI EKEQ + + L ++ + + E LE ++ +V + A +L
Sbjct: 264 VDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ 323
Query: 918 SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKV 977
S S +I+ ++++L T W Q R L + L + +Q + + + SW+ E K
Sbjct: 324 SHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEM-KA 382
Query: 978 IESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRL 1037
+ + +L +D+AG AL + + ++ A E + + L + + + +L
Sbjct: 383 LINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKL 442
Query: 1038 AEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEA 1097
+S+ + + R + LQ F RD + +W+S+ + + +ED+ ++L
Sbjct: 443 TVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSV 502
Query: 1098 EKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMF--LRQRLQALDTGWNELH 1155
E LL +HE+ + + EE K+ + E T+ + Y + R AL + N LH
Sbjct: 503 EALLKKHEDFEKSLSAQEE---KITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALH 559
Query: 1156 KMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEM--PTTLEGAEAAIKKQED 1213
+ R+ L+ S QQF RD+ + ++++N + P+ L+G ++K +
Sbjct: 560 ERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGK---VQKHQA 616
Query: 1214 FMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKD 1273
F + AN+ +I+A+ + G++L+ + D + +++ + +K E ++L++
Sbjct: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676
Query: 1274 NRDLQKFLQDCQELSLWINEKM--LTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLD 1331
Q+F ++ +++ LW+ E L + D D N+ + KH A++A++++ +D
Sbjct: 677 ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKHALLEADVAAHQDRID 735
Query: 1332 KIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCAD 1391
I + Q +K+K L +E L+ + Q+L D+ + + + D
Sbjct: 736 GITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED 795
Query: 1392 LDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK 1451
+ W+ E S + GKDL V LLKK Q L+ ++ + I+ + + A+ +EG
Sbjct: 796 EETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGH 855
Query: 1452 -STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATS 1510
+ ++V +K + K+ L ++R+ +L S + Q+ D + W+ E+ P+ S
Sbjct: 856 FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGS 915
Query: 1511 TDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADL 1570
TD+G + + + L+KK++ L ++ + I + E++Q+ RQ++A
Sbjct: 916 TDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSC------------RQQVAPT 963
Query: 1571 -----KQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE--QELYMMSEEKAKD 1623
K+L L + EK R + ++ + W E + K
Sbjct: 964 DDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKK 1023
Query: 1624 EQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGL 1683
A S +++ + EQ A Q+ +R E+ +S+R +V++LY L
Sbjct: 1024 LDPAQSASRENLLEEQG--SIALRQEQIDNQTRIT-----KEAGSVSLRMKQVEELYHSL 1076
Query: 1684 KDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREF 1743
+L E+R+G L++ + F L RE ++L+QWI E+E S E+G D E V +LQ++F +F
Sbjct: 1077 LELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDF 1136
Query: 1744 ARDTGNIGQERVDTVNHLADELINSG---------------------HSDAATIAEWKDG 1782
+D + R+ +N +A++L + G +D+ T + WK
Sbjct: 1137 QKDL-KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSA 1195
Query: 1783 ---------------LNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKK 1827
LNE W L +L + R+Q+L +++E+ +F+ DA E I++K++
Sbjct: 1196 RLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQA 1255
Query: 1828 L-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRE 1886
L + G D +V+ LQR H FE D+ ALG +V L E A RL ++ + A+D+Q++
Sbjct: 1256 LNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKC 1314
Query: 1887 NEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSV 1946
E+ +AW SL + R+ +L D+ D RF S RDLM W+ + + + E +DV+
Sbjct: 1315 TELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGA 1374
Query: 1947 ELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKW 2006
E L+ HQ + EIDAR +F + G+ LLA HYAS EIK+KL L ++R ++ W
Sbjct: 1375 EALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAW 1434
Query: 2007 EDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSA 2066
R L LE+ F RD AE W+ +E +L++ + G S+D VE LIK+HE F+K+
Sbjct: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAI 1494
Query: 2067 ATWDERFSALE 2077
+E+ +AL+
Sbjct: 1495 NVQEEKIAALQ 1505
Score = 531 bits (1367), Expect = e-150
Identities = 407/1734 (23%), Positives = 803/1734 (46%), Gaps = 112/1734 (6%)
Query: 402 AEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAAT 461
A HER + R +L L+Q R D ++W++E + + + + D ++
Sbjct: 557 ALHERAMRRRAQLADSFHLQQFFRDSDEL----KSWVNEKMKTATDEAYK-DPSNLQGKV 611
Query: 462 KKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARR 521
+KH+A E +++A + R+ A+ ++L N++ + AR + VI LW+ LLE +
Sbjct: 612 QKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKG 671
Query: 522 QRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQA 581
+L Q+ + + I W+ E++ + S DYGK L V++L +KH L+EAD+
Sbjct: 672 IKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
Query: 582 ERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLW 641
+R+ G+ A++F G D + I+ + + Y+ L + R+ +L +S RL
Sbjct: 732 DRIDGITIQARQFQDAGH----FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
Query: 642 KFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEG 701
+ F ++ +EE WIREKE I +S + GKDL V LL KH+A + E++G + ++G
Sbjct: 788 QLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
Query: 702 EDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWML 761
M+ E HF +E ++ ++ + ++W L+ ++ R++ LE++ Q+ ADA++ ++WM
Sbjct: 848 NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
Query: 762 DILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVR 821
+ IV S+D G DE S ++L+KKH+ + +++ Y ++ L EQA + Q+ A + D
Sbjct: 908 EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET 967
Query: 822 GR---LSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIP 878
G+ L+ + + K E+T + D L L + D ++ +++++ ++ +
Sbjct: 968 GKELVLALYDYQEKSPREVTMKK----GDILTLLNS-TNKDWWKVEVNDRQGFVPAAYV- 1021
Query: 879 EKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWS 938
+KL+ + E+L E + A R ++ R +G + + ++ +
Sbjct: 1022 KKLDPAQSASR--ENLLEEQGSIALRQEQIDNQTRITKEAG-----SVSLRMKQVEELYH 1074
Query: 939 QFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL 998
EL +++K L + E NE + WI EK + S +++G DL V LQ+K
Sbjct: 1075 SLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTS-EEVGADLEQVEVLQKKF 1133
Query: 999 TGMERDLVAIEAKLSDLQKEAEKLESE--HPDQAQAI----------------------- 1033
++DL A E++L D+ K AE LESE ++ QA+
Sbjct: 1134 DDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWK 1193
Query: 1034 -----------LSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQ 1082
+ + E+++ W ++ + R LG A ++Q+F RD D+ + W+
Sbjct: 1194 SARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKN 1253
Query: 1083 TAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQ 1142
A+ +++ + L + L +HE + ++ + + + E + Q ++ L++
Sbjct: 1254 QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESA-EDLQE 1312
Query: 1143 RLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLE 1202
+ L+ W+ L K + R+ L SH Q+FL D + +++N +++ E+ +
Sbjct: 1313 KCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVT 1372
Query: 1203 GAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRE 1262
GAEA +++ ++ T +DA A + G++L++ G+ S I++K+D +D +
Sbjct: 1373 GAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEK 1432
Query: 1263 TASELLMRLKDNRDLQKFLQDCQELSLWI--NEKMLTAQDMSYDEARNLHSKWLKHQAFM 1320
+ M L +LQ F +DC++ W+ E L +D D ++ + KH+ F
Sbjct: 1433 AWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKG-DSLDSVEALIKKHEDFD 1491
Query: 1321 AELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDAN 1380
+ +E + ++ QLI+ + + + + W L++ K +L ++
Sbjct: 1492 KAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQ 1551
Query: 1381 KAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQ 1440
+ F++ +++ W+ + Q SD+ KD T++ +K Q E ++ I +
Sbjct: 1552 TLQQFSRDVDEIEAWI-SEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVI 1610
Query: 1441 SQAQALSQEGK---STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDE 1497
+L + G S D V ++ + ++ L++ E+ L + + FN ++D
Sbjct: 1611 DMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDF 1670
Query: 1498 ILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSS 1557
W+ E L S D+G +L +V L+KK+Q L+ +I H+ R+ D+ ++ +++T SS+
Sbjct: 1671 DFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSA 1729
Query: 1558 LSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMS 1617
++ + + + + R +L E+HR Q++ D + E+W+ E++L + S
Sbjct: 1730 FDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGS 1789
Query: 1618 EEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVD 1677
E+ +D ++ KKH+ LE + + + + T + L D+ E I R ++
Sbjct: 1790 EDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFV 1849
Query: 1678 KLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQ 1737
+ + LK LA R +L+E Q V++ E WI E+ + S + G + L
Sbjct: 1850 EHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLL 1909
Query: 1738 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1797
++ F D + ++RV+ V +LI + I+ GLN +DL + R
Sbjct: 1910 KKHEAFETDF-TVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQR 1968
Query: 1798 TQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQAL 1856
L + +F A + I +K L ++ GRD ++V+TL TF+ +QA
Sbjct: 1969 KAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAF 2028
Query: 1857 GTQ----VRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGD 1912
+ + L++ L A + KA I+ R +++ W LL +R+ +L++
Sbjct: 2029 QQEGIANITALKDQL--LAAKHVQSKA--IEARHASLMKRWSQLLANSAARKKKLLEAQS 2084
Query: 1913 KFRFFSMVRDLML-----------WMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEID 1961
FR V DL L W E+ + + + ++ L H ++ +
Sbjct: 2085 HFR---KVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLS 2141
Query: 1962 ARNDSFTTCIELGKSL----LARKHY------ASEEIKEKLLQLTEKRKEMIDKWEDRWE 2011
+ F EL + + +A Y A EE L ++ ++R+ + K + R E
Sbjct: 2142 SAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQE 2201
Query: 2012 WLRLILEVHQFSRDASVAEAWLLGQEPYLSS-----REIGQSVDEVEKLIKRHE 2060
+ + +F++ A+ W+ YL E G ++E ++H+
Sbjct: 2202 ENDKLRQ--EFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2253
Score = 522 bits (1345), Expect = e-147
Identities = 393/1712 (22%), Positives = 796/1712 (46%), Gaps = 79/1712 (4%)
Query: 415 IRQEKLEQLARR--FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIA 472
+R++KLE R F R A E W+ E ++ S +N+ D ++ +KH+A E ++
Sbjct: 35 LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYK-DPTNLQGKLQKHQAFEAEVQ 93
Query: 473 AYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQK 532
A + + + +E + + I R + R WE LLE +R + +L L +
Sbjct: 94 ANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ 153
Query: 533 IFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQ 592
+E +MDW+++ + +V S++ G+ L VE L +K + D+ ERV VN A
Sbjct: 154 YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAA 213
Query: 593 KFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEG 652
K + + ++I+ + + +Q L LA +R+ +L + + +F ++ E
Sbjct: 214 KLIQEQHP----EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS 269
Query: 653 WIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGS 712
WI+EKE++++SDD+G+DL SV LL KH E +++ + E + + +
Sbjct: 270 WIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSA 329
Query: 713 EKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDV 772
+I+ + + W + L+A R RL ++ L +F AD D+ +W+ ++ ++++ ++
Sbjct: 330 TQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADEL 389
Query: 773 GHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERY 831
D ++L+ +H++ EI + + + E AL H S +VR +L+ + E
Sbjct: 390 ASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEER 449
Query: 832 KEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF 891
+ EL LR+Q + + L + + + + W+ ++E +L N + + L+ +E + +
Sbjct: 450 AALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKH 509
Query: 892 ESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDAL 951
E E ++ Q ++ +++ A +L+ + H + +++ ++D L +R + E R++ L
Sbjct: 510 EDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQL 569
Query: 952 LSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 1011
+ +Q + + +E KSW+ EK K +T + D + + +K E +L A +++
Sbjct: 570 ADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKDPSNLQGKVQKHQAFEAELSANQSR 627
Query: 1012 LSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDL 1071
+ L+K +KL + + +R+ E+ +W+++ + + L EA++ QQF R++
Sbjct: 628 IDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNV 687
Query: 1072 DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQ- 1130
+D + WL + +AS+D LT + L +H ++ ++ +++ +
Sbjct: 688 EDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA 747
Query: 1131 GQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEY 1190
G DA+ ++++ +AL + L + R+ L+ S QQ RD + E ++ +E
Sbjct: 748 GHFDAEN--IKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEP 805
Query: 1191 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1250
+ A T L G + +KK + + +E +I AV + G +V +G+ ++ ++ K+
Sbjct: 806 IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKL 865
Query: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1310
++ + + AS+ L+D+ Q++ D E W+ EK Y + +
Sbjct: 866 HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSA 925
Query: 1311 SKWLK-HQAFMAELASNKEWLDKIEKEGMQLISE-KPETEAVVKEKLTGLHKMWEVLEST 1368
LK H+A M++L++ + + ++ + P + KE + L+
Sbjct: 926 EALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDY------- 978
Query: 1369 TQTKAQRLFDANKAELFTQ-SCADLDKWLHGLESQ--IQSDDYGKDLTSVNILLKKQQML 1425
Q K+ R K ++ T + + D W + + Y K L ++ +L
Sbjct: 979 -QEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSA-SRENLL 1036
Query: 1426 ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASK 1485
E Q + ++ E++ +Q + + G V + V+ + LLE +RK L S
Sbjct: 1037 EEQGSIALRQ-EQIDNQTRITKEAGS----VSLRMKQVEELYHSLLELGEKRKGMLEKSC 1091
Query: 1486 EIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIF 1545
+ R+ + W+ E+ TS + G +L+ V++L KK QK+++ ++ R+ DI
Sbjct: 1092 KKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDIN 1151
Query: 1546 ERSQNIVTDSSSLSAE---AIRQR----------------------------------LA 1568
+ ++++ +S L AE A++Q+ +
Sbjct: 1152 KVAEDL--ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIK 1209
Query: 1569 DLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAV 1628
+L + W L + E+R + L AH Q+++ DA E + W+ E+ + ++ D S
Sbjct: 1210 ELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQ 1269
Query: 1629 SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPES-ERISMRQSKVDKLYAGLKDLA 1687
++ +KH+ E+ + + V+ L +T+ L+ SHPES E + + +++++ ++ L A
Sbjct: 1270 ALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAEDLQEKCTELNQAWSSLGKRA 1328
Query: 1688 EERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDT 1747
++R+ KL + H L + + DL WI + S EL +D L ER +E +
Sbjct: 1329 DQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEI 1388
Query: 1748 GNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYEL 1807
+ +L+ GH + I + D L++ ADL + R +L EL
Sbjct: 1389 -DARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLEL 1447
Query: 1808 HKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQED 1866
F+ D ++ + + L E+ G ++VE L + H F+ I ++ LQ
Sbjct: 1448 QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAF 1507
Query: 1867 AARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLW 1926
A +L AA K D I R NEVL+ W+ L +R +L ++ +F V ++ W
Sbjct: 1508 ADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAW 1566
Query: 1927 MEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASE 1986
+ + + Q + E +D ++++ HQ +AE+ A D I++G SL+ R A
Sbjct: 1567 ISEKL-QTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGS 1625
Query: 1987 E--IKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSRE 2044
E +K +L L ++ + ++ K ++ + L+ + F+ + WL E L+S +
Sbjct: 1626 EDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASED 1685
Query: 2045 IGQSVDEVEKLIKRHEAFEKSAATWDERFSAL 2076
G+ + V L+K+H+ E + ++R L
Sbjct: 1686 YGKDLASVNNLLKKHQLLEADISAHEDRLKDL 1717
Score = 514 bits (1325), Expect = e-145
Identities = 427/1897 (22%), Positives = 853/1897 (44%), Gaps = 138/1897 (7%)
Query: 313 DLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSK 372
DL W+ + ++N + A+ + G + L + KG ++ + +S
Sbjct: 372 DLTSWVTEMKALINADELASDVAGAEALLDRHQEH-----------KGEIDAHEDSFKS- 419
Query: 373 MRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLA--RRFDRK 430
A+ + G SD + E+L ER L +R+++ EQ + F R
Sbjct: 420 --ADESGQALLAAGHYASD--EVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 475
Query: 431 AAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEA 490
+ W+S+ + + ++ G L +VEA KKHE E ++A EE++ A+ A +L
Sbjct: 476 TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ 535
Query: 491 ENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVL 550
N++ ++ + R+D ++ L E RR +L + LQ+ F++ + W++E
Sbjct: 536 NNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT 595
Query: 551 VLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIR 610
+ Y K ++ +QKH EA++ R+ + + QK K +
Sbjct: 596 ATDEAY-KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAK----DEVA 650
Query: 611 DRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDL 670
R+ + +++L + + +L E+ + +F + + E W+ E E L+SDDYGKDL
Sbjct: 651 ARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDL 710
Query: 671 TSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLE 730
T+V L KH E +++ + + HF +E I+++ + ++ L+
Sbjct: 711 TNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALK 770
Query: 731 QLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVA 790
+ RK++L ++ L Q D +D + W+ + I +S++ G D Q+L+KKH+ +
Sbjct: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQ 830
Query: 791 EEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTL 849
EIA + P + + ++ +A+ +E H + DV+ +L + ++++ + R+Q L+D+L
Sbjct: 831 AEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL 890
Query: 850 ALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVN 909
+ F++A+ E W+ EKE + + + + E + + E+L +++ S + +
Sbjct: 891 QAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALR 950
Query: 910 QIARQLMHSGHPSEKEI-KAQQDKLNTRWSQFRELVDRKKDALLSALSIQN---YHLECN 965
+ A+ P++ E K L + V KK +L+ L+ N + +E N
Sbjct: 951 EQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVN 1010
Query: 966 ETKSWIREK-TKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLES 1024
+ + ++ K ++ Q + R+ E+ +A+ + D Q K
Sbjct: 1011 DRQGFVPAAYVKKLDPAQ----------SASRENLLEEQGSIALRQEQIDNQTRITK--- 1057
Query: 1025 EHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTA 1084
+A ++ R+ ++ +++ + + R+ L ++ K R+ ++ Q W++ + A
Sbjct: 1058 ----EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAA 1113
Query: 1085 IASEDMPNTLTEAEKL----------LTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTD 1134
+ SE++ L + E L L +E+ +I+ ED + M E V Q
Sbjct: 1114 LTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ 1173
Query: 1135 AQYMFLRQ-------------------------RLQALDTGWNELHKMWENRQNLLSQSH 1169
Y + + ++ L+ W L ++ E R LL +H
Sbjct: 1174 EVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAH 1233
Query: 1170 AYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVV 1229
Q+F RD + + ++ + L L +A +K E F + A +K+N++
Sbjct: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
Query: 1230 ETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSL 1289
ET RL+ +++ +QEK ++ + A + +L D+ DLQ+FL D ++L
Sbjct: 1294 ETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMS 1353
Query: 1290 WINE-KMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETE 1348
WIN + L + D + + +HQ E+ + E+ G QL++
Sbjct: 1354 WINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYAS 1413
Query: 1349 AVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDY 1408
+K+KL L + LE + L + +LF + C + W+ E+ + ++D
Sbjct: 1414 PEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDK 1473
Query: 1409 GKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKRLTVQTKF 1467
G L SV L+KK + + + V++++I LQ+ A L G + ++ S+R V ++
Sbjct: 1474 GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRW 1533
Query: 1468 MELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQT-VQLLIKK 1526
L + E++ L S+ + QF+RDV++ W+ E+ L T++D + T +Q +K
Sbjct: 1534 RRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEK--LQTASDESYKDPTNIQSKHQK 1591
Query: 1527 NQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE-AIRQRLADLKQLWGLLIEETEKRH 1585
+Q + E+ + RI + + +++ + +E A++ RLA L W L++++ ++
Sbjct: 1592 HQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKS 1651
Query: 1586 RRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYA 1645
++L+EA++ Q + + + W+SE E + SE+ KD S ++LKKHQ+LE + +
Sbjct: 1652 QKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHE 1711
Query: 1646 ETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNR 1705
+ + L+ + +L+ S ++ ++ ++ ++ + +K +A RR KL+E HRL Q R
Sbjct: 1712 DRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFR 1771
Query: 1706 EVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFR----EFARDTGNIGQERVDTVNHL 1761
++DD E WI E++++ GS + G+D V L+++ + E A I Q +DT L
Sbjct: 1772 DMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAI-QGVLDTGKKL 1830
Query: 1762 ADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRI 1821
+D+ +A++ E W +L +L R Q L S E +F + +E I
Sbjct: 1831 SDDNTIGKEEIQQRLAQFV----EHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWI 1886
Query: 1822 QDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKAD 1880
+K + E+ G ++ L + H FE D +V + + L + +
Sbjct: 1887 NEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEEN 1946
Query: 1881 DIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLM-LWMEDVIRQIEAQEK 1939
K + L S L+ ++R +D F F+ D++ W+ + ++ +
Sbjct: 1947 ISSKMKG--LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDY 2004
Query: 1940 PRDVSSVELLMNNHQGIKAEIDA-RNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEK 1998
RD+SSV+ L+ + A + A + + L LLA KH S+ I+ + L ++
Sbjct: 2005 GRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKR 2064
Query: 1999 RKEMIDKWEDRWEWLRLILEVH---------QFSRDASVAEAWLLGQEPYLSSREIGQSV 2049
+++ R + L L + H F++ AS +W E L+ S+
Sbjct: 2065 WSQLLANSAARKKKL-LEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSL 2123
Query: 2050 DEVEKLIKRHEAFEKSAATWDERFSALERLT----------------TLELLE------- 2086
+E++ L + H+AF S ++ F+ L L T+E LE
Sbjct: 2124 EEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQ 2183
Query: 2087 ----VRRQQEEEERKRRPPSPEPSTKVSEEAESQQQW 2119
R + ++E++R+ + + + ++ A + QW
Sbjct: 2184 KIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQW 2220
Score = 514 bits (1323), Expect = e-145
Identities = 413/1897 (21%), Positives = 838/1897 (44%), Gaps = 119/1897 (6%)
Query: 256 ISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLL 315
I HP+E+ I T + ++K LA++ R GK+ A ++++ + +
Sbjct: 216 IQEQHPEEELIKTKQDEVNAAWQRLKGLALQ--RQGKLFGAA-----EVQRFNRDVDETI 268
Query: 316 EWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRA 375
WI++ ++ + F L VQ L+ LE L ++ K++A
Sbjct: 269 SWIKEKEQLMASDDFGRDLASVQALLRKHE---------------GLERDLAALEDKVKA 313
Query: 376 NNQKVYMPREGKLIS---------DINKAWERLEKAEHERELALRNELIRQEKLEQLARR 426
+ ++ +S ++ WE++ ER L + Q R
Sbjct: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ--------R 365
Query: 427 FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVAR 486
F +W++E + L++ D D+ EA +H+ + +I A+E+ ++ +
Sbjct: 366 FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
Query: 487 ELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDE 546
L A ++ + + + LLEL RRQ+ E + LQ +++ + +WM +
Sbjct: 426 ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
Query: 547 MKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDP 606
+ +L++D G L VE LL+KH E + Q E++ ++ A K + Y D
Sbjct: 486 QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNH-YAMEDV 544
Query: 607 QVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDY 666
RD + L + A RRA+L +S L +FF + E + W+ EK K + + Y
Sbjct: 545 ATRRDALLSRR---NALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY 601
Query: 667 GKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQW 726
KD +++ + KH+AFE E+S + K G+ +I H+ +++ R+ + W
Sbjct: 602 -KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
Query: 727 ANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH 786
L + + ++ +L EA+ QF + +DI+ W+ ++ ++S D G D + Q+L KKH
Sbjct: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
Query: 787 KDVAEEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQAL 845
+ ++A ++ +D + QA H ++ +++ + + RY+ + E RKQ L
Sbjct: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
Query: 846 QDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRV 905
D+L L ++F + + E WI EKE + + L ++ + + ++L+ E+ R+
Sbjct: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
Query: 906 AVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECN 965
V Q ++ GH + +++KA+ +LN +W + +++ L +L Q Y + N
Sbjct: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
Query: 966 ETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESE 1025
E +SW+REK ++ ST D G D AL +K + DL A + + L+++A+ +
Sbjct: 901 EAESWMREKEPIVGST-DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQ 959
Query: 1026 ----HPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRT 1081
+ + ++ L + + T K +L ++ + +++D Q ++
Sbjct: 960 VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVP-- 1017
Query: 1082 QTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1141
A + P E LL + +I + + + ++ G +
Sbjct: 1018 -AAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSL------------ 1064
Query: 1142 QRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTL 1201
R++ ++ ++ L ++ E R+ +L +S R+ + + ++N +E L E+ L
Sbjct: 1065 -RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
Query: 1202 EGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQ-------------- 1247
E E KK +DF + ANE ++ + + L S+G + ++ +Q
Sbjct: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEG-LMAEEVQAVQQQEVYGMMPRD 1182
Query: 1248 -----------------------EKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDC 1284
+ +++R R ++ A E L ++Q+F +D
Sbjct: 1183 ETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDA 1242
Query: 1285 QELSLWINEK--MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLIS 1342
E WI EK L + +D A ++ + KH+ F +LA+ + ++ + + +LI
Sbjct: 1243 DETKEWIEEKNQALNTDNYGHDLA-SVQALQRKHEGFERDLAALGDKVNSLGETAERLIQ 1301
Query: 1343 EKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQ 1402
PE+ ++EK T L++ W L + +L D++ + F DL W++G+
Sbjct: 1302 SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGL 1361
Query: 1403 IQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKRL 1461
+ SD+ KD+T LL++ Q +++ R + + Q L G ++ E+ K
Sbjct: 1362 VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLD 1421
Query: 1462 TVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQ 1521
+ + +L + +R+ L E+ F+RD E W+ R + D G +L +V+
Sbjct: 1422 ILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVE 1481
Query: 1522 LLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEET 1581
LIKK++ K I + +I + + ++ + I R ++ W L +
Sbjct: 1482 ALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKAQM 1540
Query: 1582 EKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAV 1641
++ +L E+ QQ+ D E EAW+SE+ L S+E KD + S +KHQ E +
Sbjct: 1541 IEKRSKLGESQTLQQFSRDVDEIEAWISEK-LQTASDESYKDPTNIQSKHQKHQAFEAEL 1599
Query: 1642 EDYAETVHQLSKTSRALVADSH--PESERISMRQSKVDKLYAGLKDLAEERRGKLDERHR 1699
A+ + + +L+ + + R + + + L + E+ KL E ++
Sbjct: 1600 HANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANK 1659
Query: 1700 LFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVN 1759
N + D + W++E E + S + G+D V L ++ + D + ++R+ +N
Sbjct: 1660 QQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI-SAHEDRLKDLN 1718
Query: 1760 HLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFG 1819
AD L+ S D + + + +D +N + + + +R L S+ LH+F+ D +
Sbjct: 1719 SQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEES 1778
Query: 1820 RIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDK 1878
I++K + E+ GRD V+ L++ H E ++ A ++ + + +L K
Sbjct: 1779 WIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGK 1838
Query: 1879 ADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQE 1938
++IQ+R + +E WK L +R RL ++ + +F + V + W+ + + + +++
Sbjct: 1839 -EEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASED 1897
Query: 1939 KPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEK 1998
+++++ L+ H+ + + D G+ L+ + ++ E I K+ L K
Sbjct: 1898 YGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGK 1957
Query: 1999 RKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKR 2058
++ R L QF+ A V E+W+ +E L + + G+ + V+ L+ +
Sbjct: 1958 VSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTK 2017
Query: 2059 HEAFEKSAATWDERFSALERLTTL--ELLEVRRQQEE 2093
E F+ + + + +T L +LL + Q +
Sbjct: 2018 QETFDAGLQAFQQ--EGIANITALKDQLLAAKHVQSK 2052
Score = 503 bits (1294), Expect = e-141
Identities = 430/1835 (23%), Positives = 824/1835 (44%), Gaps = 115/1835 (6%)
Query: 298 IETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFT 357
++ +K+++ Y D+++WI I+ + + L V+ + F ++T
Sbjct: 146 LQAQKLVQ-YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQT--DMAAHE 202
Query: 358 EKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQ 417
E+ N EV F + + ++ + + ++N AW+RL + LAL+ RQ
Sbjct: 203 ERVN-EVNQFAAKLIQEQHPEEELIKTKQ---DEVNAAWQRL------KGLALQ----RQ 248
Query: 418 EKLEQLA--RRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYE 475
KL A +RF+R +W+ E ++L++ D+FG DL +V+A +KHE +E D+AA E
Sbjct: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
Query: 476 ERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQ 535
++V+A+ A A L+ + +I +++ +I WE + L R RL + LQ+
Sbjct: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368
Query: 536 EMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFA 595
+ + W+ EMK L+ + + + G E LL +H + +I + + + S Q A
Sbjct: 369 DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ--A 426
Query: 596 TDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIR 655
G+ D +R+++ + L +L RR + E+ L F+ + + + W+
Sbjct: 427 LLAAGHYASDE--VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMS 484
Query: 656 EKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKI 715
++E L ++D G L SV LL KH FE +S + + +I H+ E +
Sbjct: 485 KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDV 544
Query: 716 RERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHD 775
R + + L + + R+ +L ++ L QF D+D++ +W+ + +K ++ + D
Sbjct: 545 ATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-TATDEAYKD 603
Query: 776 EYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERYKEV 834
+ Q V+KH+ E++ + +D L + L H +V R++ + +K++
Sbjct: 604 PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKL 663
Query: 835 AELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESL 894
E T L+ L++ + + ELW+ E E L + + L +++ +Q + L
Sbjct: 664 LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
Query: 895 EPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSA 954
E ++ R+ + ARQ +GH + IK +Q+ L R+ +E + +K L +
Sbjct: 724 EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783
Query: 955 LSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSD 1014
L +Q + + ++WIREK + ST + G DL GV L +K ++ ++ E ++
Sbjct: 784 LRLQQLFRDVEDEETWIREKEPIAAST-NRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
Query: 1015 LQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDF 1074
+ ++ + E A+ + ++L E++ WE +K R L ++ + QQ+ D ++
Sbjct: 843 VTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902
Query: 1075 QSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTD 1134
+SW+ + + S D AE LL +HE + +++ Y Q +R+
Sbjct: 903 ESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE----------- 951
Query: 1135 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQ-FLRDTKQAE----AFLNNQE 1189
Q RQ++ D E + L+ + YQ+ R+ + LN+
Sbjct: 952 -QAQSCRQQVAPTDD---------ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTN 1001
Query: 1190 YVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNI-NSDRIQE 1248
E+ AA K+ D A+ E N + E G + I N RI +
Sbjct: 1002 KDWWKVEVNDRQGFVPAAYVKKLD--PAQSASRE--NLLEEQGSIALRQEQIDNQTRITK 1057
Query: 1249 KVDSIDDRHRKNRETASELLMRLKDNR------DLQKFL--QDCQELSLWINEK--MLTA 1298
+ S+ R ++ E LL L + R +KF+ ++ EL WINEK LT+
Sbjct: 1058 EAGSVSLRMKQVEELYHSLL-ELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTS 1116
Query: 1299 QDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE---KPETEAVVKEKL 1355
+++ D + K F +L +N+ L I K L SE E +AV ++++
Sbjct: 1117 EEVGAD-LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEV 1175
Query: 1356 TG---------------------------------LHKMWEVLESTTQTKAQRLFDANKA 1382
G L++ W L+ + ++Q L A++
Sbjct: 1176 YGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEV 1235
Query: 1383 ELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ 1442
+ F + + +W+ + +D+YG DL SV L +K + E + ++ L
Sbjct: 1236 QRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGET 1295
Query: 1443 AQALSQ-EGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWV 1501
A+ L Q +S +++ K + + L + ++RK L S ++ +F D D + W+
Sbjct: 1296 AERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWI 1355
Query: 1502 GERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE 1561
L +S + ++ + L++++Q + EI + Q ++ S E
Sbjct: 1356 NGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE 1415
Query: 1562 AIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKA 1621
I+Q+L L Q L + +R L++ Q ++ D +AE WM+ +E ++ +E+K
Sbjct: 1416 -IKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKG 1474
Query: 1622 KDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA 1681
S +++KKH+ ++A+ E + L + L+A H IS R+++V +
Sbjct: 1475 DSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWR 1534
Query: 1682 GLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFR 1741
LK E+R KL E L Q +R+VD++E WI+E+ + S E +D ++ ++ +
Sbjct: 1535 RLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEK-LQTASDESYKDPTNIQSKHQKHQ 1593
Query: 1742 EFARDTGNIGQERVDTVNHLADELINSG---HSDAATIAEWKDGLNEAWADLLELIDTRT 1798
F + + +R+ V + + LI G S+ A A L + W L++ ++
Sbjct: 1594 AFEAEL-HANADRIRGVIDMGNSLIERGACAGSEDAVKARLA-ALADQWQFLVQKSAEKS 1651
Query: 1799 QILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALG 1857
Q L + + F K+ + + L E+ G+D +V L + H E DI A
Sbjct: 1652 QKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHE 1711
Query: 1858 TQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFF 1917
+++ L A L + A D + KR+ + ++ + SRR +L ++ +FF
Sbjct: 1712 DRLKDLNSQADSLMTSSAFDTSQVKDKRDT-INGRFQKIKSMAASRRAKLNESHRLHQFF 1770
Query: 1918 SMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL 1977
+ D W+++ + +++ RD++ V+ L H+ ++AE+ A + ++ GK L
Sbjct: 1771 RDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKL 1830
Query: 1978 LARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQE 2037
EEI+++L Q E KE+ R + L LE QF + EAW+ +
Sbjct: 1831 SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKM 1890
Query: 2038 PYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDER 2072
++S + G ++ ++ L+K+HEAFE +R
Sbjct: 1891 TLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDR 1925
Score = 417 bits (1071), Expect = e-116
Identities = 355/1623 (21%), Positives = 715/1623 (44%), Gaps = 99/1623 (6%)
Query: 499 ITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGK 558
I R+ V+ + EL RRQ+LE + Q ++ + W+ E K+ + S + K
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE-KLQIASDENYK 73
Query: 559 HLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEF 618
++ LQKH EA++ + + ++ + ++G + IR R+ +
Sbjct: 74 DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS----ETIRTRLMELHR 129
Query: 619 CYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLS 678
++ L + E+ +L ++++L ++ E + WI +KE I++S++ G+DL V L
Sbjct: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189
Query: 679 KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 738
K F+ +M+ + + +I E+H E I+ + + W L+ L+ R+
Sbjct: 190 KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
Query: 739 RLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 798
+L A+ + +F D D+ +W+ + ++++S D G D S Q+L++KH+ + ++A
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
Query: 799 TLDTLHEQASALPQEH-AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 857
+ L +A L Q H + ++ + + ++++ L R L D+ L + ++
Sbjct: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
Query: 858 ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMH 917
W+ E + +N ++ + E + R + + E++ ++ + L+
Sbjct: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
Query: 918 SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKV 977
+GH + E++ + L+ + EL + ++ + +Q ++ + + +W+ K +
Sbjct: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWM-SKQEA 488
Query: 978 IESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRL 1037
+DLG+ L V AL +K E+ L A E K++ L + A KL + + + +R
Sbjct: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
Query: 1038 AEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLS---RTQTAIASEDMPNTL 1094
+ + R A L ++ LQQF RD D+ +SW++ +T T A +D N
Sbjct: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
Query: 1095 TEAEKLLTQHENI---KNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGW 1151
+ +K + ++ ID E+ QK+ D+ + R+ + + W
Sbjct: 609 GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE--------VAARMNEVISLW 660
Query: 1152 NELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQ 1211
+L + E + L +++ QQF R+ + E +L E LA + L + KK
Sbjct: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
Query: 1212 EDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRL 1271
+ A++++I+ + R+ G+ +++ I++K +++ R+ +E +L
Sbjct: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
Query: 1272 KDNRDLQKFLQDCQELSLWINEK-MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWL 1330
D+ LQ+ +D ++ WI EK + A + + + KHQA AE+A ++ +
Sbjct: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
Query: 1331 DKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCA 1390
+ ++G ++ E VK KL L++ WE L++ + Q L D+ +A+ +
Sbjct: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
Query: 1391 DLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEG 1450
+ + W+ E + S DYGKD S LLKK + L + + I+ L+ QAQ+ Q+
Sbjct: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960
Query: 1451 KSTDEVDSKRLTVQTKFMELLEP--LNERKHNLLASKEIHQFNRD---VEDEILWVGERM 1505
TD+ K L + + P + +K ++L ++ N+D VE V +R
Sbjct: 961 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTL--LNSTNKDWWKVE-----VNDRQ 1013
Query: 1506 PLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQ 1565
+ + L Q ++N E QG + + I ++ S+S
Sbjct: 1014 GFVPAA-YVKKLDPAQSASRENLL---EEQGSIALRQEQIDNQTRITKEAGSVSL----- 1064
Query: 1566 RLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQ 1625
R+ +++L+ L+E EKR LE++ + + +A E + W++E+E + SEE D +
Sbjct: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
Query: 1626 SAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKV--------- 1676
+ KK ++ ++ + ++K + L ++ E +++Q +V
Sbjct: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDET 1184
Query: 1677 ---------------------------DKLYAGLKDLAEERRGKLDERHRLFQLNREVDD 1709
++ + L+ LAEER L H + + +R+ D+
Sbjct: 1185 DSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADE 1244
Query: 1710 LEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSG 1769
++WI E+ + G D V LQ + F RD +G ++V+++ A+ LI S
Sbjct: 1245 TKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALG-DKVNSLGETAERLIQSH 1303
Query: 1770 HSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQD-KHKKL 1828
A + E LN+AW+ L + D R L S++L +F D +++ I +
Sbjct: 1304 PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
Query: 1829 PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENE 1888
+EL +D E L H +I A + ++ +L A G A K++ +
Sbjct: 1364 SDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLA--HGHYASPEIKQKLD 1421
Query: 1889 VLEAWKSLLDACESRRVRLVDTGDKFRFFSM-VRDLMLWMEDVIRQIEAQEKPRDVSSVE 1947
+L+ ++ L+ +R ++D + + F WM + ++K + SVE
Sbjct: 1422 ILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVE 1481
Query: 1948 LLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWE 2007
L+ H+ I+ + + L+A HYA +I + +R E++D+W
Sbjct: 1482 ALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDI-------SSRRNEVLDRWR 1534
Query: 2008 -------DRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHE 2060
++ L + QFSRD EAW + ++ +S E + ++ ++H+
Sbjct: 1535 RLKAQMIEKRSKLGESQTLQQFSRDVDEIEAW-ISEKLQTASDESYKDPTNIQSKHQKHQ 1593
Query: 2061 AFE 2063
AFE
Sbjct: 1594 AFE 1596
Score = 362 bits (930), Expect = 2e-99
Identities = 322/1435 (22%), Positives = 620/1435 (43%), Gaps = 129/1435 (8%)
Query: 924 KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD 983
++I+ ++ ++ R+ +F+EL ++ L + Q + + E + WI+EK ++ ++ +
Sbjct: 13 EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQI--ASDE 70
Query: 984 LGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV 1043
D + +K E ++ A + L + + SE ++ I +RL E+
Sbjct: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 1044 WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQ 1103
WE + ++ + L +A KL Q+LR+ +D W++ + + SE++ L E L +
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 1104 HENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQN 1163
E + ++ +EE ++ + Q Q + + ++ + ++ W L + RQ
Sbjct: 191 FEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL-IKTKQDEVNAAWQRLKGLALQRQG 249
Query: 1164 LLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEE 1223
L + Q+F RD + +++ +E ++A + L +A ++K E + A E+
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
Query: 1224 KINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQD 1283
K+ A+ RL +++ +IQ K + + + R A+E RL D+ LQ+FL D
Sbjct: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
Query: 1284 CQELSLWINEK--MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLI 1341
++L+ W+ E ++ A +++ D A + +HQ E+ ++++ ++ G L+
Sbjct: 370 FRDLTSWVTEMKALINADELASDVA-GAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
Query: 1342 SEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLES 1401
+ V+EKLT L + L + + Q+ +LF + +D W+ E+
Sbjct: 429 AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
Query: 1402 QIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKR 1460
+ ++D G L SV LLKK + E + ++++I L A L Q + ++V ++R
Sbjct: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
Query: 1461 LTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTV 1520
+ ++ L E R+ L S + QF RD ++ WV E+M AT + + +
Sbjct: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-KDPSNL 607
Query: 1521 QLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEE 1580
Q ++K+Q + E+ +Q RID + + Q ++ D + + + + R+ ++ LW L+E
Sbjct: 608 QGKVQKHQAFEAELSANQSRIDALEKAGQKLI-DVNHYAKDEVAARMNEVISLWKKLLEA 666
Query: 1581 TEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQA 1640
TE + +L EA++ QQ+ + + E W+ E E ++ S++ KD + ++ KKH +LE
Sbjct: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
Query: 1641 VEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRL 1700
V + + + ++ +R H ++E I +Q + Y LK+ R+ KL + RL
Sbjct: 727 VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786
Query: 1701 FQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNH 1760
QL R+V+D E WI E+E +A S G+D V L ++ + + + R+ V
Sbjct: 787 QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAG-HEPRIKAVTQ 845
Query: 1761 LADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGR 1820
+ ++ GH A + LN+ W L R Q L S + +++ DA E
Sbjct: 846 KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESW 905
Query: 1821 IQDKHKKLPE-ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDA--ARLQAAYAGD 1877
+++K + + G+D+++ E L + H D+ A G+ ++ L+E A R Q A D
Sbjct: 906 MREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDD 965
Query: 1878 KA---------DDIQKRENEVLEAWKSLLDACESRRVRL--VDTGDKFRFFSMVRDLMLW 1926
+ D +K EV +L S V+ D+ F
Sbjct: 966 ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA------ 1019
Query: 1927 MEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASE 1986
+++++ P +S E L+ I + ++ E G L K E
Sbjct: 1020 ---YVKKLD----PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQV--E 1070
Query: 1987 EIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIG 2046
E+ LL+L EKRK M++K ++ R+A+ + W+ +E L+S E+G
Sbjct: 1071 ELYHSLLELGEKRKGMLEKSCKKF----------MLFREANELQQWINEKEAALTSEEVG 1120
Query: 2047 QSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPS 2106
+++VE L K+ + F+K + R +
Sbjct: 1121 ADLEQVEVLQKKFDDFQKDLKANESRLKDIN----------------------------- 1151
Query: 2107 TKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSP 2166
KV+E+ ES+ GL AE+ + V E+ T SK +SP
Sbjct: 1152 -KVAEDLESE--------------GLMAEE-----VQAVQQQEVYGMMPRDETDSKTASP 1191
Query: 2167 IPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKAS-SRSW--- 2222
S + R+ + + + L HE + ++ A ++ W
Sbjct: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEE 1251
Query: 2223 -----------HNVYCV--INNQEMGFYKD-----------AKTAASGIPYHSEVPVSLK 2258
H++ V + + GF +D +TA I H E L+
Sbjct: 1252 KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQ 1311
Query: 2259 EAVCEVALDYK---KKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAISSDK 2310
E E+ + K+ K +L D ++ D ++ +WI I +SSD+
Sbjct: 1312 EKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE 1366
Score = 297 bits (760), Expect = 9e-80
Identities = 181/542 (33%), Positives = 293/542 (54%), Gaps = 5/542 (0%)
Query: 1559 SAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSE 1618
+AE I++R + + E + R ++LE+++R Q + DA E E W+ E+ L + S+
Sbjct: 11 TAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEK-LQIASD 69
Query: 1619 EKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDK 1678
E KD + L+KHQ E V+ + + +L +T ++++ H SE I R ++ +
Sbjct: 70 ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHR 129
Query: 1679 LYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQE 1738
+ L + E+ KL + +L Q RE +D+ WI ++E + S ELGQD EHV +LQ+
Sbjct: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189
Query: 1739 RFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRT 1798
+F EF D +ERV+ VN A +LI H + I +D +N AW L L R
Sbjct: 190 KFEEFQTDMA-AHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQ 248
Query: 1799 QILAASYELHKFYHDAKEIFGRIQDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALG 1857
L + E+ +F D E I++K + + ++ GRD +V+ L R H E D+ AL
Sbjct: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
Query: 1858 TQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFF 1917
+V+ L +A RLQ ++ A IQ + E++ W+ + R RL D+ RF
Sbjct: 309 DKVKALCAEADRLQQSHPLS-ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFL 367
Query: 1918 SMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL 1977
+ RDL W+ ++ I A E DV+ E L++ HQ K EIDA DSF + E G++L
Sbjct: 368 ADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQAL 427
Query: 1978 LARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQE 2037
LA HYAS+E++EKL L+E+R +++ WE R + +++ F RD + W+ QE
Sbjct: 428 LAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQE 487
Query: 2038 PYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERK 2097
+L + ++G S+D VE L+K+HE FEKS + +E+ +AL+ T +L++ E+
Sbjct: 488 AFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT-KLIQNNHYAMEDVAT 546
Query: 2098 RR 2099
RR
Sbjct: 547 RR 548
Score = 251 bits (641), Expect = 6e-66
Identities = 212/911 (23%), Positives = 417/911 (45%), Gaps = 74/911 (8%)
Query: 1346 ETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQS 1405
ET ++E+ + + + + + Q+L D+ + + F + +L+KW+ + QI S
Sbjct: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE-KLQIAS 68
Query: 1406 DDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT 1465
D+ KD T++ L+K Q E +++ I +L + EG E T++T
Sbjct: 69 DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASE------TIRT 122
Query: 1466 KFME-------LLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQ 1518
+ ME LLE + E+ LL ++++ Q+ R+ ED + W+ ++ + TS + G +L+
Sbjct: 123 RLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLE 182
Query: 1519 TVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLI 1578
V++L KK + Q ++ H+ R++++ + + ++ + E I+ + ++ W L
Sbjct: 183 HVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP-EEELIKTKQDEVNAAWQRLK 241
Query: 1579 EETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILE 1638
+R +L A Q++ D E +W+ E+E M S++ +D S ++L+KH+ LE
Sbjct: 242 GLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLE 301
Query: 1639 QAVEDYAETVHQLSKTSRALVADSHP-ESERISMRQSKVDKLYAGLKDLAEERRGKLDER 1697
+ + + V L + L SHP + +I +++ ++ + ++ LA ER +L++
Sbjct: 302 RDLAALEDKVKALCAEADRL-QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
Query: 1698 HRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDT 1757
+RL + + DL W+ E + + + EL D L +R +E + + ++ +
Sbjct: 361 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEI-DAHEDSFKS 419
Query: 1758 VNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEI 1817
+ L+ +GH + + E L+E A LLEL + R Q +L FY D +++
Sbjct: 420 ADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQV 479
Query: 1818 FGRIQDKHK-KLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL--QAAY 1874
+ + L E+LG ++VE L + H FE + A ++ L E A +L Y
Sbjct: 480 DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHY 539
Query: 1875 AGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQI 1934
A +D+ R + +L +L + RR +L D+ +FF +L W+ + ++
Sbjct: 540 A---MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-T 595
Query: 1935 EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQ 1994
E +D S+++ + HQ +AE+ A + G+ L+ HYA +E+ ++ +
Sbjct: 596 ATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNE 655
Query: 1995 LTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEK 2054
+ K++++ E + LR + QF+R+ E WL E +L+S + G+ + V+
Sbjct: 656 VISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQN 715
Query: 2055 LIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAE 2114
L K+H E A +R + ++ R+ Q+ +E +
Sbjct: 716 LQKKHALLEADVAAHQDRIDGI-------TIQARQFQDAGHFD------------AENIK 756
Query: 2115 SQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSD- 2173
+Q+ ++ E + + P ++A+++ ++ ++ T +E PI + T+
Sbjct: 757 KKQEALVARYEALKE---PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG 813
Query: 2174 ---------RKAKTALPAQSAATLP---ARTQETPSAQMEGF------------LNRKHE 2209
K AL A+ A P A TQ+ + EG LN+K
Sbjct: 814 KDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQK-- 871
Query: 2210 WEAHNKKASSR 2220
WEA KAS R
Sbjct: 872 WEALKAKASQR 882
Score = 98.2 bits (243), Expect = 8e-20
Identities = 128/611 (20%), Positives = 244/611 (39%), Gaps = 86/611 (14%)
Query: 277 FSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVG 336
F K+K++A + E+ ++ + + + D WI++ +++ + + L G
Sbjct: 1746 FQKIKSMAASRRA------KLNESHRLHQFFRDM-DDEESWIKEKKLLVGSEDYGRDLTG 1798
Query: 337 VQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPRE-GKLISDIN-- 393
VQ NL +++++ A+ + + GK +SD N
Sbjct: 1799 VQ----------------------NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTI 1836
Query: 394 ---KAWERLEK-AEHEREL----ALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLV 445
+ +RL + EH +EL A R + + +E LE ++F E W++E LV
Sbjct: 1837 GKEEIQQRLAQFVEHWKELKQLAAARGQRL-EESLEY--QQFVANVEEEEAWINEKMTLV 1893
Query: 446 SQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDN 505
+ +++G L A++ KKHEA ETD +++RV V ++L +N H + I+++
Sbjct: 1894 ASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKG 1953
Query: 506 VIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVED 565
+ L + R+ +L+ N + + + W+ E + + + DYG+ L V+
Sbjct: 1954 LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQT 2013
Query: 566 LLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ 625
LL K +A G+QA + G+ A+ K + I R A + + +L
Sbjct: 2014 LLTKQETFDA--GLQAFQQEGI-ANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLA 2070
Query: 626 LAAERRARLEES----RRLWKFFWEMAEE----EGWIREKEKILSSDDYGKDLTSVMRLL 677
+A R+ +L E+ R++ F A++ W E+ L+ L + L
Sbjct: 2071 NSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALR 2130
Query: 678 SKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRK 737
H AF +S F Q + + + + + + E W NL+++ R+
Sbjct: 2131 EAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERE 2190
Query: 738 KRL--------EEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDV 789
L E L +F A+ W+ + T++ + +
Sbjct: 2191 LELQKEQRRQEENDKLRQEFAQHANAFHQWIQE----------------TRTYLLDGSCM 2234
Query: 790 AEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRL-RKQALQDT 848
EE TL Q A ++H E +R +L IE+ + E L K T
Sbjct: 2235 VEESG-------TLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHST 2287
Query: 849 LALYKMFSEAD 859
+ L + + + D
Sbjct: 2288 VGLAQQWDQLD 2298
Score = 47.8 bits (112), Expect = 1e-04
Identities = 61/296 (20%), Positives = 119/296 (40%), Gaps = 18/296 (6%)
Query: 241 AEQHLGLTKLLDPED--ISVDHPDEKSIITYVVTYYHYFSKMKA-LAVEGKRIGKVLDNA 297
A Q G+ + +D ++ H K+I + +S++ A A K++ + +
Sbjct: 2027 AFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2086
Query: 298 IETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFT 357
+ E + + AS W E L + NSL ++ +A + +R+ +
Sbjct: 2087 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQ-A 2145
Query: 358 EKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQ 417
+ L L I+S A+N + E + + W L+K EREL L+ E RQ
Sbjct: 2146 DFNQLAELDRQIKSFRVASNPYTWFTMEA-----LEETWRNLQKIIKERELELQKEQRRQ 2200
Query: 418 EKLEQLARRFDRKAAMRETWLSENQRLVSQ-----DNFGFDLPAVEAATKKHEAIETDIA 472
E+ ++L + F + A W+ E + + + G +EA +KH+ +I
Sbjct: 2201 EENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ----EIR 2256
Query: 473 AYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNL 528
A +++ + + +E D K + + W+ L +L + LE +
Sbjct: 2257 AMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQI 2312
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 609 bits (1570), Expect = e-173
Identities = 402/1417 (28%), Positives = 707/1417 (49%), Gaps = 78/1417 (5%)
Query: 712 SEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 771
+E I+ER + +++ ++LS +R+++LE++ FQ DA++++ W+ + L+I S +
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
Query: 772 VGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEER 830
D + Q ++KH+ E+ + L E + + E H S +R RL + +
Sbjct: 72 Y-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 831 YKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHR 890
++ + E R + L L + E + WI++KE + + ++ + LE +EV+Q +
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 891 FESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDA 950
FE + +M RV VNQ A +L+ HP E+ IK +QD++N W + + L +++
Sbjct: 191 FEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK 250
Query: 951 LLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEA 1010
L A +Q ++ + +ET SWI+EK +++ S D G DLA V AL RK G+ERDL A+E
Sbjct: 251 LFGAAEVQRFNRDVDETISWIKEKEQLMAS-DDFGRDLASVQALLRKHEGLERDLAALED 309
Query: 1011 KLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRD 1070
K+ L EA++L+ HP A I + E+ WE+++T R A L ++ +LQ+FL D
Sbjct: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
Query: 1071 LDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQ 1130
D SW++ + I ++++ + + AE LL +H+ K EID +E+ ++ + G+ +
Sbjct: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
Query: 1131 GQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEY 1190
A +R++L L L ++WE R+ Q Q F RDT+Q + +++ QE
Sbjct: 430 AGHYASDE-VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
Query: 1191 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1250
L + ++ +L+ EA +KK EDF ++ A EEKI A+ E +L+ + + + + +
Sbjct: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
Query: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1310
D++ R E A +L D+ LQ+F +D EL W+NEKM TA D +Y + NL
Sbjct: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
Query: 1311 SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ 1370
K KHQAF AEL++N+ +D +EK G +LI + V ++ + +W+ L T+
Sbjct: 609 GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATE 668
Query: 1371 TKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQME 1430
K +L +AN+ + F ++ D++ WL+ +E + SDDYGKDLT+V L KK +LE +
Sbjct: 669 LKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA 728
Query: 1431 VRKKEIEELQSQAQALSQEGK-STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQ 1489
+ I+ + QA+ G + + K+ + ++ L EP+ RK L S + Q
Sbjct: 729 AHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
Query: 1490 FNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQ 1549
RDVEDE W+ E+ P+A ST+ G +L VQ L+KK+Q LQ EI GH+PRI + ++
Sbjct: 789 LFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG- 847
Query: 1550 NIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMS 1609
N + + +AE ++ +L +L Q W L + +R + LE++ +AQQY+ DA EAE+WM
Sbjct: 848 NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
Query: 1610 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669
E+E + S + KDE SA ++LKKH+ L + Y ++ L + +++ P +
Sbjct: 908 EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET 967
Query: 1670 SMRQSKVDKLYAGLKDLAEE--RRGKLDERHRLFQLNR--------EVDDLEQWIAEREV 1719
+L L D E+ R + + L LN EV+D + ++ V
Sbjct: 968 G------KELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYV 1021
Query: 1720 VAGSHELGQDYEHVTMLQERFREFARDTGNIG--QERVDTVNHLADELINSGHSDAATIA 1777
+ Q +L+E+ G+I QE++D + E A +++
Sbjct: 1022 --KKLDPAQSASRENLLEEQ--------GSIALRQEQIDNQTRITKE--------AGSVS 1063
Query: 1778 EWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQ 1836
+ E + LLEL + R +L S + + +A E+ I +K L EE+G D
Sbjct: 1064 LRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
Query: 1837 NTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQA-AYAGDKADDIQKRE--------- 1886
VE LQ+ F+ D++A ++++ + + A L++ ++ +Q++E
Sbjct: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
Query: 1887 -------------------------NEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVR 1921
E+ E W+SL E R L + RF
Sbjct: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
Query: 1922 DLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARK 1981
+ W+E+ + + D++SV+ L H+G + ++ A D + E + L+
Sbjct: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH 1303
Query: 1982 HYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLS 2041
++E+++EK +L + + + + R L ++ +F D +W+ G +S
Sbjct: 1304 PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
Query: 2042 SREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALER 2078
S E+ + V E L++RH+ F A E+
Sbjct: 1364 SDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
Score = 565 bits (1455), Expect = e-160
Identities = 403/1511 (26%), Positives = 737/1511 (48%), Gaps = 84/1511 (5%)
Query: 620 YQELCQLAAERRARLEESRRLWKFFWEMAEE-EGWIREKEKILSSDDYGKDLTSVMRLLS 678
Y +L+ RR +LE+S R ++FF AEE E WI+EK +I S ++Y KD T++ L
Sbjct: 26 YHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIASDENY-KDPTNLQGKLQ 83
Query: 679 KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 738
KH+AFE E+ SG + + G MI+E HF SE IR R++ + QW L + +
Sbjct: 84 KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGI 143
Query: 739 RLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 798
+L +A L Q+ + +D+ W+ D IV+S ++G D + L KK ++ ++A +
Sbjct: 144 KLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE 203
Query: 799 TLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 857
++ +++ A+ L QE H E ++ + + ++ + L R+ L + + +
Sbjct: 204 RVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRD 263
Query: 858 ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMH 917
D WI EKEQ + + L ++ + + E LE ++ +V + A +L
Sbjct: 264 VDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ 323
Query: 918 SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKV 977
S S +I+ ++++L T W Q R L + L + +Q + + + SW+ E K
Sbjct: 324 SHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEM-KA 382
Query: 978 IESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRL 1037
+ + +L +D+AG AL + + ++ A E + + L + + + +L
Sbjct: 383 LINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKL 442
Query: 1038 AEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEA 1097
+S+ + + R + LQ F RD + +W+S+ + + +ED+ ++L
Sbjct: 443 TVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSV 502
Query: 1098 EKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMF--LRQRLQALDTGWNELH 1155
E LL +HE+ + + EE K+ + E T+ + Y + R AL + N LH
Sbjct: 503 EALLKKHEDFEKSLSAQEE---KITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALH 559
Query: 1156 KMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEM--PTTLEGAEAAIKKQED 1213
+ R+ L+ S QQF RD+ + ++++N + P+ L+G ++K +
Sbjct: 560 ERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGK---VQKHQA 616
Query: 1214 FMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKD 1273
F + AN+ +I+A+ + G++L+ + D + +++ + +K E ++L++
Sbjct: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676
Query: 1274 NRDLQKFLQDCQELSLWINEKM--LTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLD 1331
Q+F ++ +++ LW+ E L + D D N+ + KH A++A++++ +D
Sbjct: 677 ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKHALLEADVAAHQDRID 735
Query: 1332 KIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCAD 1391
I + Q +K+K L +E L+ + Q+L D+ + + + D
Sbjct: 736 GITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED 795
Query: 1392 LDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK 1451
+ W+ E S + GKDL V LLKK Q L+ ++ + I+ + + A+ +EG
Sbjct: 796 EETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGH 855
Query: 1452 -STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATS 1510
+ ++V +K + K+ L ++R+ +L S + Q+ D + W+ E+ P+ S
Sbjct: 856 FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGS 915
Query: 1511 TDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADL 1570
TD+G + + + L+KK++ L ++ + I + E++Q+ RQ++A
Sbjct: 916 TDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSC------------RQQVAPT 963
Query: 1571 -----KQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE--QELYMMSEEKAKD 1623
K+L L + EK R + ++ + W E + K
Sbjct: 964 DDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKK 1023
Query: 1624 EQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGL 1683
A S +++ + EQ A Q+ +R E+ +S+R +V++LY L
Sbjct: 1024 LDPAQSASRENLLEEQG--SIALRQEQIDNQTRIT-----KEAGSVSLRMKQVEELYHSL 1076
Query: 1684 KDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREF 1743
+L E+R+G L++ + F L RE ++L+QWI E+E S E+G D E V +LQ++F +F
Sbjct: 1077 LELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDF 1136
Query: 1744 ARDTGNIGQERVDTVNHLADELINSG---------------------HSDAATIAEWKDG 1782
+D + R+ +N +A++L + G +D+ T + WK
Sbjct: 1137 QKDL-KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSA 1195
Query: 1783 ---------------LNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKK 1827
LNE W L +L + R+Q+L +++E+ +F+ DA E I++K++
Sbjct: 1196 RLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQA 1255
Query: 1828 L-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRE 1886
L + G D +V+ LQR H FE D+ ALG +V L E A RL ++ + A+D+Q++
Sbjct: 1256 LNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKC 1314
Query: 1887 NEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSV 1946
E+ +AW SL + R+ +L D+ D RF S RDLM W+ + + + E +DV+
Sbjct: 1315 TELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGA 1374
Query: 1947 ELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKW 2006
E L+ HQ + EIDAR +F + G+ LLA HYAS EIK+KL L ++R ++ W
Sbjct: 1375 EALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAW 1434
Query: 2007 EDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSA 2066
R L LE+ F RD AE W+ +E +L++ + G S+D VE LIK+HE F+K+
Sbjct: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAI 1494
Query: 2067 ATWDERFSALE 2077
+E+ +AL+
Sbjct: 1495 NVQEEKIAALQ 1505
Score = 527 bits (1357), Expect = e-149
Identities = 409/1739 (23%), Positives = 806/1739 (46%), Gaps = 117/1739 (6%)
Query: 402 AEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAAT 461
A HER + R +L L+Q R D ++W++E + + + + D ++
Sbjct: 557 ALHERAMRRRAQLADSFHLQQFFRDSDEL----KSWVNEKMKTATDEAYK-DPSNLQGKV 611
Query: 462 KKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARR 521
+KH+A E +++A + R+ A+ ++L N++ + AR + VI LW+ LLE +
Sbjct: 612 QKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKG 671
Query: 522 QRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQA 581
+L Q+ + + I W+ E++ + S DYGK L V++L +KH L+EAD+
Sbjct: 672 IKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
Query: 582 ERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLW 641
+R+ G+ A++F G D + I+ + + Y+ L + R+ +L +S RL
Sbjct: 732 DRIDGITIQARQFQDAGH----FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
Query: 642 KFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEG 701
+ F ++ +EE WIREKE I +S + GKDL V LL KH+A + E++G + ++G
Sbjct: 788 QLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
Query: 702 EDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWML 761
M+ E HF +E ++ ++ + ++W L+ ++ R++ LE++ Q+ ADA++ ++WM
Sbjct: 848 NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
Query: 762 DILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVR 821
+ IV S+D G DE S ++L+KKH+ + +++ Y ++ L EQA + Q+ A + D
Sbjct: 908 EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET 967
Query: 822 GR---LSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIP 878
G+ L+ + + K E+T + D L L + D ++ +++++ ++ +
Sbjct: 968 GKELVLALYDYQEKSPREVTMKK----GDILTLLNS-TNKDWWKVEVNDRQGFVPAAYV- 1021
Query: 879 EKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWS 938
+KL+ + E+L E + A R ++ R +G + + ++ +
Sbjct: 1022 KKLDPAQSASR--ENLLEEQGSIALRQEQIDNQTRITKEAG-----SVSLRMKQVEELYH 1074
Query: 939 QFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL 998
EL +++K L + E NE + WI EK + S +++G DL V LQ+K
Sbjct: 1075 SLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTS-EEVGADLEQVEVLQKKF 1133
Query: 999 TGMERDLVAIEAKLSDLQKEAEKLESE--HPDQAQAI----------------------- 1033
++DL A E++L D+ K AE LESE ++ QA+
Sbjct: 1134 DDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWK 1193
Query: 1034 -----------LSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQ 1082
+ + E+++ W ++ + R LG A ++Q+F RD D+ + W+
Sbjct: 1194 SARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKN 1253
Query: 1083 TAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQ 1142
A+ +++ + L + L +HE + ++ + + + E + Q ++ L++
Sbjct: 1254 QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESA-EDLQE 1312
Query: 1143 RLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLE 1202
+ L+ W+ L K + R+ L SH Q+FL D + +++N +++ E+ +
Sbjct: 1313 KCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVT 1372
Query: 1203 GAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRE 1262
GAEA +++ ++ T +DA A + G++L++ G+ S I++K+D +D +
Sbjct: 1373 GAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEK 1432
Query: 1263 TASELLMRLKDNRDLQKFLQDCQELSLWI--NEKMLTAQDMSYDEARNLHSKWLKHQAFM 1320
+ M L +LQ F +DC++ W+ E L +D D ++ + KH+ F
Sbjct: 1433 AWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKG-DSLDSVEALIKKHEDFD 1491
Query: 1321 AELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDAN 1380
+ +E + ++ QLI+ + + + + W L++ K +L ++
Sbjct: 1492 KAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQ 1551
Query: 1381 KAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNI--LL---KKQQMLENQMEVRKKE 1435
+ F++ +++ W+ + Q SD+ KD T++ + LL +K Q E ++
Sbjct: 1552 TLQQFSRDVDEIEAWI-SEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADR 1610
Query: 1436 IEELQSQAQALSQEGK---STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNR 1492
I + +L + G S D V ++ + ++ L++ E+ L + + FN
Sbjct: 1611 IRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNT 1670
Query: 1493 DVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIV 1552
++D W+ E L S D+G +L +V L+KK+Q L+ +I H+ R+ D+ ++ +++
Sbjct: 1671 GIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLM 1730
Query: 1553 TDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQE 1612
T SS+ ++ + + + + R +L E+HR Q++ D + E+W+ E++
Sbjct: 1731 T-SSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKK 1789
Query: 1613 LYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMR 1672
L + SE+ +D ++ KKH+ LE + + + + T + L D+ E I R
Sbjct: 1790 LLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQR 1849
Query: 1673 QSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEH 1732
++ + + LK LA R +L+E Q V++ E WI E+ + S + G
Sbjct: 1850 LAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAA 1909
Query: 1733 VTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLE 1792
+ L ++ F D + ++RV+ V +LI + I+ GLN +DL +
Sbjct: 1910 IQGLLKKHEAFETDF-TVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEK 1968
Query: 1793 LIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEH 1851
R L + +F A + I +K L ++ GRD ++V+TL TF+
Sbjct: 1969 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA 2028
Query: 1852 DIQALGTQ----VRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRL 1907
+QA + + L++ L A + KA I+ R +++ W LL +R+ +L
Sbjct: 2029 GLQAFQQEGIANITALKDQL--LAAKHVQSKA--IEARHASLMKRWSQLLANSAARKKKL 2084
Query: 1908 VDTGDKFRFFSMVRDLML-----------WMEDVIRQIEAQEKPRDVSSVELLMNNHQGI 1956
++ FR V DL L W E+ + + + ++ L H
Sbjct: 2085 LEAQSHFR---KVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAF 2141
Query: 1957 KAEIDARNDSFTTCIELGKSL----LARKHY------ASEEIKEKLLQLTEKRKEMIDKW 2006
++ + + F EL + + +A Y A EE L ++ ++R+ + K
Sbjct: 2142 RSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKE 2201
Query: 2007 EDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSS-----REIGQSVDEVEKLIKRHE 2060
+ R E + + +F++ A+ W+ YL E G ++E ++H+
Sbjct: 2202 QRRQEENDKLRQ--EFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
Score = 519 bits (1337), Expect = e-146
Identities = 394/1716 (22%), Positives = 798/1716 (46%), Gaps = 82/1716 (4%)
Query: 415 IRQEKLEQLARR--FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIA 472
+R++KLE R F R A E W+ E ++ S +N+ D ++ +KH+A E ++
Sbjct: 35 LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYK-DPTNLQGKLQKHQAFEAEVQ 93
Query: 473 AYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQK 532
A + + + +E + + I R + R WE LLE +R + +L L +
Sbjct: 94 ANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ 153
Query: 533 IFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQ 592
+E +MDW+++ + +V S++ G+ L VE L +K + D+ ERV VN A
Sbjct: 154 YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAA 213
Query: 593 KFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEG 652
K + + ++I+ + + +Q L LA +R+ +L + + +F ++ E
Sbjct: 214 KLIQEQHP----EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS 269
Query: 653 WIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGS 712
WI+EKE++++SDD+G+DL SV LL KH E +++ + E + + +
Sbjct: 270 WIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSA 329
Query: 713 EKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDV 772
+I+ + + W + L+A R RL ++ L +F AD D+ +W+ ++ ++++ ++
Sbjct: 330 TQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADEL 389
Query: 773 GHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERY 831
D ++L+ +H++ EI + + + E AL H S +VR +L+ + E
Sbjct: 390 ASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEER 449
Query: 832 KEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF 891
+ EL LR+Q + + L + + + + W+ ++E +L N + + L+ +E + +
Sbjct: 450 AALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKH 509
Query: 892 ESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDAL 951
E E ++ Q ++ +++ A +L+ + H + +++ ++D L +R + E R++ L
Sbjct: 510 EDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQL 569
Query: 952 LSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 1011
+ +Q + + +E KSW+ EK K +T + D + + +K E +L A +++
Sbjct: 570 ADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKDPSNLQGKVQKHQAFEAELSANQSR 627
Query: 1012 LSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDL 1071
+ L+K +KL + + +R+ E+ +W+++ + + L EA++ QQF R++
Sbjct: 628 IDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNV 687
Query: 1072 DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQ- 1130
+D + WL + +AS+D LT + L +H ++ ++ +++ +
Sbjct: 688 EDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA 747
Query: 1131 GQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEY 1190
G DA+ ++++ +AL + L + R+ L+ S QQ RD + E ++ +E
Sbjct: 748 GHFDAEN--IKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEP 805
Query: 1191 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1250
+ A T L G + +KK + + +E +I AV + G +V +G+ ++ ++ K+
Sbjct: 806 IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKL 865
Query: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1310
++ + + AS+ L+D+ Q++ D E W+ EK Y + +
Sbjct: 866 HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSA 925
Query: 1311 SKWLK-HQAFMAELASNKEWLDKIEKEGMQLISE-KPETEAVVKEKLTGLHKMWEVLEST 1368
LK H+A M++L++ + + ++ + P + KE + L+
Sbjct: 926 EALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDY------- 978
Query: 1369 TQTKAQRLFDANKAELFTQ-SCADLDKWLHGLESQ--IQSDDYGKDLTSVNILLKKQQML 1425
Q K+ R K ++ T + + D W + + Y K L ++ +L
Sbjct: 979 -QEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSA-SRENLL 1036
Query: 1426 ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASK 1485
E Q + ++ E++ +Q + + G V + V+ + LLE +RK L S
Sbjct: 1037 EEQGSIALRQ-EQIDNQTRITKEAGS----VSLRMKQVEELYHSLLELGEKRKGMLEKSC 1091
Query: 1486 EIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIF 1545
+ R+ + W+ E+ TS + G +L+ V++L KK QK+++ ++ R+ DI
Sbjct: 1092 KKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDIN 1151
Query: 1546 ERSQNIVTDSSSLSAE---AIRQR----------------------------------LA 1568
+ ++++ +S L AE A++Q+ +
Sbjct: 1152 KVAEDL--ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIK 1209
Query: 1569 DLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAV 1628
+L + W L + E+R + L AH Q+++ DA E + W+ E+ + ++ D S
Sbjct: 1210 ELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQ 1269
Query: 1629 SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPES-ERISMRQSKVDKLYAGLKDLA 1687
++ +KH+ E+ + + V+ L +T+ L+ SHPES E + + +++++ ++ L A
Sbjct: 1270 ALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAEDLQEKCTELNQAWSSLGKRA 1328
Query: 1688 EERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDT 1747
++R+ KL + H L + + DL WI + S EL +D L ER +E +
Sbjct: 1329 DQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEI 1388
Query: 1748 GNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYEL 1807
+ +L+ GH + I + D L++ ADL + R +L EL
Sbjct: 1389 -DARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLEL 1447
Query: 1808 HKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQED 1866
F+ D ++ + + L E+ G ++VE L + H F+ I ++ LQ
Sbjct: 1448 QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAF 1507
Query: 1867 AARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLW 1926
A +L AA K D I R NEVL+ W+ L +R +L ++ +F V ++ W
Sbjct: 1508 ADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAW 1566
Query: 1927 MEDVIRQI--EAQEKPRDVSSVELLMNN--HQGIKAEIDARNDSFTTCIELGKSLLARKH 1982
+ + ++ E+ + P ++ +LL + HQ +AE+ A D I++G SL+ R
Sbjct: 1567 ISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGA 1626
Query: 1983 YASEE--IKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL 2040
A E +K +L L ++ + ++ K ++ + L+ + F+ + WL E L
Sbjct: 1627 CAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALL 1686
Query: 2041 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL 2076
+S + G+ + V L+K+H+ E + ++R L
Sbjct: 1687 ASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDL 1722
Score = 516 bits (1329), Expect = e-145
Identities = 428/1900 (22%), Positives = 854/1900 (44%), Gaps = 139/1900 (7%)
Query: 313 DLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSK 372
DL W+ + ++N + A+ + G + L + KG ++ + +S
Sbjct: 372 DLTSWVTEMKALINADELASDVAGAEALLDRHQEH-----------KGEIDAHEDSFKS- 419
Query: 373 MRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLA--RRFDRK 430
A+ + G SD + E+L ER L +R+++ EQ + F R
Sbjct: 420 --ADESGQALLAAGHYASD--EVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 475
Query: 431 AAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEA 490
+ W+S+ + + ++ G L +VEA KKHE E ++A EE++ A+ A +L
Sbjct: 476 TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ 535
Query: 491 ENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVL 550
N++ ++ + R+D ++ L E RR +L + LQ+ F++ + W++E
Sbjct: 536 NNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT 595
Query: 551 VLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIR 610
+ Y K ++ +QKH EA++ R+ + + QK K +
Sbjct: 596 ATDEAY-KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAK----DEVA 650
Query: 611 DRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDL 670
R+ + +++L + + +L E+ + +F + + E W+ E E L+SDDYGKDL
Sbjct: 651 ARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDL 710
Query: 671 TSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLE 730
T+V L KH E +++ + + HF +E I+++ + ++ L+
Sbjct: 711 TNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALK 770
Query: 731 QLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVA 790
+ RK++L ++ L Q D +D + W+ + I +S++ G D Q+L+KKH+ +
Sbjct: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQ 830
Query: 791 EEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTL 849
EIA + P + + ++ +A+ +E H + DV+ +L + ++++ + R+Q L+D+L
Sbjct: 831 AEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL 890
Query: 850 ALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVN 909
+ F++A+ E W+ EKE + + + + E + + E+L +++ S + +
Sbjct: 891 QAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALR 950
Query: 910 QIARQLMHSGHPSEKEI-KAQQDKLNTRWSQFRELVDRKKDALLSALSIQN---YHLECN 965
+ A+ P++ E K L + V KK +L+ L+ N + +E N
Sbjct: 951 EQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVN 1010
Query: 966 ETKSWIREK-TKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLES 1024
+ + ++ K ++ Q + R+ E+ +A+ + D Q K
Sbjct: 1011 DRQGFVPAAYVKKLDPAQ----------SASRENLLEEQGSIALRQEQIDNQTRITK--- 1057
Query: 1025 EHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTA 1084
+A ++ R+ ++ +++ + + R+ L ++ K R+ ++ Q W++ + A
Sbjct: 1058 ----EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAA 1113
Query: 1085 IASEDMPNTLTEAEKL----------LTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTD 1134
+ SE++ L + E L L +E+ +I+ ED + M E V Q
Sbjct: 1114 LTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ 1173
Query: 1135 AQYMFLRQ-------------------------RLQALDTGWNELHKMWENRQNLLSQSH 1169
Y + + ++ L+ W L ++ E R LL +H
Sbjct: 1174 EVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAH 1233
Query: 1170 AYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVV 1229
Q+F RD + + ++ + L L +A +K E F + A +K+N++
Sbjct: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
Query: 1230 ETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSL 1289
ET RL+ +++ +QEK ++ + A + +L D+ DLQ+FL D ++L
Sbjct: 1294 ETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMS 1353
Query: 1290 WINE-KMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETE 1348
WIN + L + D + + +HQ E+ + E+ G QL++
Sbjct: 1354 WINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYAS 1413
Query: 1349 AVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDY 1408
+K+KL L + LE + L + +LF + C + W+ E+ + ++D
Sbjct: 1414 PEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDK 1473
Query: 1409 GKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKRLTVQTKF 1467
G L SV L+KK + + + V++++I LQ+ A L G + ++ S+R V ++
Sbjct: 1474 GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRW 1533
Query: 1468 MELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH--NLQTVQLLIK 1525
L + E++ L S+ + QF+RDV++ W+ E++ A+ + N+Q +LL K
Sbjct: 1534 RRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSK 1593
Query: 1526 --KNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE-AIRQRLADLKQLWGLLIEETE 1582
K+Q + E+ + RI + + +++ + +E A++ RLA L W L++++
Sbjct: 1594 HQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSA 1653
Query: 1583 KRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVE 1642
++ ++L+EA++ Q + + + W+SE E + SE+ KD S ++LKKHQ+LE +
Sbjct: 1654 EKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADIS 1713
Query: 1643 DYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQ 1702
+ + + L+ + +L+ S ++ ++ ++ ++ + +K +A RR KL+E HRL Q
Sbjct: 1714 AHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQ 1773
Query: 1703 LNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFR----EFARDTGNIGQERVDTV 1758
R++DD E WI E++++ GS + G+D V L+++ + E A I Q +DT
Sbjct: 1774 FFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAI-QGVLDTG 1832
Query: 1759 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIF 1818
L+D+ +A++ E W +L +L R Q L S E +F + +E
Sbjct: 1833 KKLSDDNTIGKEEIQQRLAQFV----EHWKELKQLAAARGQRLEESLEYQQFVANVEEEE 1888
Query: 1819 GRIQDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGD 1877
I +K + E+ G ++ L + H FE D +V + + L
Sbjct: 1889 AWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHH 1948
Query: 1878 KADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLM-LWMEDVIRQIEA 1936
+ + K + L S L+ ++R +D F F+ D++ W+ + ++
Sbjct: 1949 EENISSKMKG--LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKT 2006
Query: 1937 QEKPRDVSSVELLMNNHQGIKAEIDA-RNDSFTTCIELGKSLLARKHYASEEIKEKLLQL 1995
+ RD+SSV+ L+ + A + A + + L LLA KH S+ I+ + L
Sbjct: 2007 DDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASL 2066
Query: 1996 TEKRKEMIDKWEDRWEWLRLILEVH---------QFSRDASVAEAWLLGQEPYLSSREIG 2046
++ +++ R + L L + H F++ AS +W E L+
Sbjct: 2067 MKRWSQLLANSAARKKKL-LEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRC 2125
Query: 2047 QSVDEVEKLIKRHEAFEKSAATWDERFSALERLT----------------TLELLE---- 2086
S++E++ L + H+AF S ++ F+ L L T+E LE
Sbjct: 2126 NSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWR 2185
Query: 2087 -------VRRQQEEEERKRRPPSPEPSTKVSEEAESQQQW 2119
R + ++E++R+ + + + ++ A + QW
Sbjct: 2186 NLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQW 2225
Score = 509 bits (1310), Expect = e-143
Identities = 413/1902 (21%), Positives = 839/1902 (44%), Gaps = 124/1902 (6%)
Query: 256 ISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLL 315
I HP+E+ I T + ++K LA++ R GK+ A ++++ + +
Sbjct: 216 IQEQHPEEELIKTKQDEVNAAWQRLKGLALQ--RQGKLFGAA-----EVQRFNRDVDETI 268
Query: 316 EWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRA 375
WI++ ++ + F L VQ L+ LE L ++ K++A
Sbjct: 269 SWIKEKEQLMASDDFGRDLASVQALLRKHE---------------GLERDLAALEDKVKA 313
Query: 376 NNQKVYMPREGKLIS---------DINKAWERLEKAEHERELALRNELIRQEKLEQLARR 426
+ ++ +S ++ WE++ ER L + Q R
Sbjct: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ--------R 365
Query: 427 FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVAR 486
F +W++E + L++ D D+ EA +H+ + +I A+E+ ++ +
Sbjct: 366 FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
Query: 487 ELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDE 546
L A ++ + + + LLEL RRQ+ E + LQ +++ + +WM +
Sbjct: 426 ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
Query: 547 MKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDP 606
+ +L++D G L VE LL+KH E + Q E++ ++ A K + Y D
Sbjct: 486 QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNH-YAMEDV 544
Query: 607 QVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDY 666
RD + L + A RRA+L +S L +FF + E + W+ EK K + + Y
Sbjct: 545 ATRRDALLSRR---NALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY 601
Query: 667 GKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQW 726
KD +++ + KH+AFE E+S + K G+ +I H+ +++ R+ + W
Sbjct: 602 -KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
Query: 727 ANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH 786
L + + ++ +L EA+ QF + +DI+ W+ ++ ++S D G D + Q+L KKH
Sbjct: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
Query: 787 KDVAEEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQAL 845
+ ++A ++ +D + QA H ++ +++ + + RY+ + E RKQ L
Sbjct: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
Query: 846 QDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRV 905
D+L L ++F + + E WI EKE + + L ++ + + ++L+ E+ R+
Sbjct: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
Query: 906 AVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECN 965
V Q ++ GH + +++KA+ +LN +W + +++ L +L Q Y + N
Sbjct: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
Query: 966 ETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESE 1025
E +SW+REK ++ ST D G D AL +K + DL A + + L+++A+ +
Sbjct: 901 EAESWMREKEPIVGST-DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQ 959
Query: 1026 ----HPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRT 1081
+ + ++ L + + T K +L ++ + +++D Q ++
Sbjct: 960 VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVP-- 1017
Query: 1082 QTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1141
A + P E LL + +I + + + ++ G +
Sbjct: 1018 -AAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSL------------ 1064
Query: 1142 QRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTL 1201
R++ ++ ++ L ++ E R+ +L +S R+ + + ++N +E L E+ L
Sbjct: 1065 -RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
Query: 1202 EGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQ-------------- 1247
E E KK +DF + ANE ++ + + L S+G + ++ +Q
Sbjct: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEG-LMAEEVQAVQQQEVYGMMPRD 1182
Query: 1248 -----------------------EKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDC 1284
+ +++R R ++ A E L ++Q+F +D
Sbjct: 1183 ETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDA 1242
Query: 1285 QELSLWINEK--MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLIS 1342
E WI EK L + +D A ++ + KH+ F +LA+ + ++ + + +LI
Sbjct: 1243 DETKEWIEEKNQALNTDNYGHDLA-SVQALQRKHEGFERDLAALGDKVNSLGETAERLIQ 1301
Query: 1343 EKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQ 1402
PE+ ++EK T L++ W L + +L D++ + F DL W++G+
Sbjct: 1302 SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGL 1361
Query: 1403 IQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKRL 1461
+ SD+ KD+T LL++ Q +++ R + + Q L G ++ E+ K
Sbjct: 1362 VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLD 1421
Query: 1462 TVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQ 1521
+ + +L + +R+ L E+ F+RD E W+ R + D G +L +V+
Sbjct: 1422 ILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVE 1481
Query: 1522 LLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEET 1581
LIKK++ K I + +I + + ++ + I R ++ W L +
Sbjct: 1482 ALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKAQM 1540
Query: 1582 EKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSA-----VSMLKKHQI 1636
++ +L E+ QQ+ D E EAW+SE+ L S+E KD + +S +KHQ
Sbjct: 1541 IEKRSKLGESQTLQQFSRDVDEIEAWISEK-LQTASDESYKDPTNIQLSKLLSKHQKHQA 1599
Query: 1637 LEQAVEDYAETVHQLSKTSRALVADSH--PESERISMRQSKVDKLYAGLKDLAEERRGKL 1694
E + A+ + + +L+ + + R + + + L + E+ KL
Sbjct: 1600 FEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKL 1659
Query: 1695 DERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQER 1754
E ++ N + D + W++E E + S + G+D V L ++ + D + ++R
Sbjct: 1660 KEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI-SAHEDR 1718
Query: 1755 VDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA 1814
+ +N AD L+ S D + + + +D +N + + + +R L S+ LH+F+ D
Sbjct: 1719 LKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDM 1778
Query: 1815 KEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAA 1873
+ I++K + E+ GRD V+ L++ H E ++ A ++ + + +L
Sbjct: 1779 DDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDD 1838
Query: 1874 YAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQ 1933
K ++IQ+R + +E WK L +R RL ++ + +F + V + W+ + +
Sbjct: 1839 NTIGK-EEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTL 1897
Query: 1934 IEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLL 1993
+ +++ +++++ L+ H+ + + D G+ L+ + ++ E I K+
Sbjct: 1898 VASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMK 1957
Query: 1994 QLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVE 2053
L K ++ R L QF+ A V E+W+ +E L + + G+ + V+
Sbjct: 1958 GLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQ 2017
Query: 2054 KLIKRHEAFEKSAATWDERFSALERLTTL--ELLEVRRQQEE 2093
L+ + E F+ + + + +T L +LL + Q +
Sbjct: 2018 TLLTKQETFDAGLQAFQQ--EGIANITALKDQLLAAKHVQSK 2057
Score = 498 bits (1283), Expect = e-140
Identities = 431/1843 (23%), Positives = 824/1843 (44%), Gaps = 126/1843 (6%)
Query: 298 IETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFT 357
++ +K+++ Y D+++WI I+ + + L V+ + F ++T
Sbjct: 146 LQAQKLVQ-YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQT--DMAAHE 202
Query: 358 EKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQ 417
E+ N EV F + + ++ + + ++N AW+RL + LAL+ RQ
Sbjct: 203 ERVN-EVNQFAAKLIQEQHPEEELIKTKQ---DEVNAAWQRL------KGLALQ----RQ 248
Query: 418 EKLEQLA--RRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYE 475
KL A +RF+R +W+ E ++L++ D+FG DL +V+A +KHE +E D+AA E
Sbjct: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
Query: 476 ERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQ 535
++V+A+ A A L+ + +I +++ +I WE + L R RL + LQ+
Sbjct: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368
Query: 536 EMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFA 595
+ + W+ EMK L+ + + + G E LL +H + +I + + + S Q A
Sbjct: 369 DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ--A 426
Query: 596 TDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIR 655
G+ D +R+++ + L +L RR + E+ L F+ + + + W+
Sbjct: 427 LLAAGHYASDE--VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMS 484
Query: 656 EKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKI 715
++E L ++D G L SV LL KH FE +S + + +I H+ E +
Sbjct: 485 KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDV 544
Query: 716 RERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHD 775
R + + L + + R+ +L ++ L QF D+D++ +W+ + +K ++ + D
Sbjct: 545 ATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-TATDEAYKD 603
Query: 776 EYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERYKEV 834
+ Q V+KH+ E++ + +D L + L H +V R++ + +K++
Sbjct: 604 PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKL 663
Query: 835 AELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESL 894
E T L+ L++ + + ELW+ E E L + + L +++ +Q + L
Sbjct: 664 LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
Query: 895 EPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSA 954
E ++ R+ + ARQ +GH + IK +Q+ L R+ +E + +K L +
Sbjct: 724 EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783
Query: 955 LSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSD 1014
L +Q + + ++WIREK + ST + G DL GV L +K ++ ++ E ++
Sbjct: 784 LRLQQLFRDVEDEETWIREKEPIAAST-NRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
Query: 1015 LQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDF 1074
+ ++ + E A+ + ++L E++ WE +K R L ++ + QQ+ D ++
Sbjct: 843 VTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902
Query: 1075 QSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTD 1134
+SW+ + + S D AE LL +HE + +++ Y Q +R+
Sbjct: 903 ESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE----------- 951
Query: 1135 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQ-FLRDTKQAE----AFLNNQE 1189
Q RQ++ D E + L+ + YQ+ R+ + LN+
Sbjct: 952 -QAQSCRQQVAPTDD---------ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTN 1001
Query: 1190 YVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNI-NSDRIQE 1248
E+ AA K+ D A+ E N + E G + I N RI +
Sbjct: 1002 KDWWKVEVNDRQGFVPAAYVKKLD--PAQSASRE--NLLEEQGSIALRQEQIDNQTRITK 1057
Query: 1249 KVDSIDDRHRKNRETASELLMRLKDNR------DLQKFL--QDCQELSLWINEK--MLTA 1298
+ S+ R ++ E LL L + R +KF+ ++ EL WINEK LT+
Sbjct: 1058 EAGSVSLRMKQVEELYHSLL-ELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTS 1116
Query: 1299 QDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE---KPETEAVVKEKL 1355
+++ D + K F +L +N+ L I K L SE E +AV ++++
Sbjct: 1117 EEVGAD-LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEV 1175
Query: 1356 TG---------------------------------LHKMWEVLESTTQTKAQRLFDANKA 1382
G L++ W L+ + ++Q L A++
Sbjct: 1176 YGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEV 1235
Query: 1383 ELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ 1442
+ F + + +W+ + +D+YG DL SV L +K + E + ++ L
Sbjct: 1236 QRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGET 1295
Query: 1443 AQALSQ-EGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWV 1501
A+ L Q +S +++ K + + L + ++RK L S ++ +F D D + W+
Sbjct: 1296 AERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWI 1355
Query: 1502 GERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE 1561
L +S + ++ + L++++Q + EI + Q ++ S E
Sbjct: 1356 NGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE 1415
Query: 1562 AIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKA 1621
I+Q+L L Q L + +R L++ Q ++ D +AE WM+ +E ++ +E+K
Sbjct: 1416 -IKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKG 1474
Query: 1622 KDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA 1681
S +++KKH+ ++A+ E + L + L+A H IS R+++V +
Sbjct: 1475 DSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWR 1534
Query: 1682 GLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQ---- 1737
LK E+R KL E L Q +R+VD++E WI+E+ A + Y+ T +Q
Sbjct: 1535 RLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASD----ESYKDPTNIQLSKL 1590
Query: 1738 ----ERFREFARDTGNIGQERVDTVNHLADELINSG---HSDAATIAEWKDGLNEAWADL 1790
++ + F + + +R+ V + + LI G S+ A A L + W L
Sbjct: 1591 LSKHQKHQAFEAEL-HANADRIRGVIDMGNSLIERGACAGSEDAVKARLA-ALADQWQFL 1648
Query: 1791 LELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTF 1849
++ ++Q L + + F K+ + + L E+ G+D +V L + H
Sbjct: 1649 VQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLL 1708
Query: 1850 EHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVD 1909
E DI A +++ L A L + A D + KR+ + ++ + SRR +L +
Sbjct: 1709 EADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDT-INGRFQKIKSMAASRRAKLNE 1767
Query: 1910 TGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTT 1969
+ +FF + D W+++ + +++ RD++ V+ L H+ ++AE+ A +
Sbjct: 1768 SHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1827
Query: 1970 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2029
++ GK L EEI+++L Q E KE+ R + L LE QF +
Sbjct: 1828 VLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1887
Query: 2030 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDER 2072
EAW+ + ++S + G ++ ++ L+K+HEAFE +R
Sbjct: 1888 EAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDR 1930
Score = 414 bits (1063), Expect = e-115
Identities = 356/1627 (21%), Positives = 715/1627 (43%), Gaps = 102/1627 (6%)
Query: 499 ITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGK 558
I R+ V+ + EL RRQ+LE + Q ++ + W+ E K+ + S + K
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE-KLQIASDENYK 73
Query: 559 HLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEF 618
++ LQKH EA++ + + ++ + ++G + IR R+ +
Sbjct: 74 DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS----ETIRTRLMELHR 129
Query: 619 CYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLS 678
++ L + E+ +L ++++L ++ E + WI +KE I++S++ G+DL V L
Sbjct: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189
Query: 679 KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 738
K F+ +M+ + + +I E+H E I+ + + W L+ L+ R+
Sbjct: 190 KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
Query: 739 RLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 798
+L A+ + +F D D+ +W+ + ++++S D G D S Q+L++KH+ + ++A
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
Query: 799 TLDTLHEQASALPQEH-AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 857
+ L +A L Q H + ++ + + ++++ L R L D+ L + ++
Sbjct: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
Query: 858 ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMH 917
W+ E + +N ++ + E + R + + E++ ++ + L+
Sbjct: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
Query: 918 SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKV 977
+GH + E++ + L+ + EL + ++ + +Q ++ + + +W+ K +
Sbjct: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWM-SKQEA 488
Query: 978 IESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRL 1037
+DLG+ L V AL +K E+ L A E K++ L + A KL + + + +R
Sbjct: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
Query: 1038 AEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLS---RTQTAIASEDMPNTL 1094
+ + R A L ++ LQQF RD D+ +SW++ +T T A +D N
Sbjct: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
Query: 1095 TEAEKLLTQHENI---KNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGW 1151
+ +K + ++ ID E+ QK+ D+ + R+ + + W
Sbjct: 609 GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE--------VAARMNEVISLW 660
Query: 1152 NELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQ 1211
+L + E + L +++ QQF R+ + E +L E LA + L + KK
Sbjct: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
Query: 1212 EDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRL 1271
+ A++++I+ + R+ G+ +++ I++K +++ R+ +E +L
Sbjct: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
Query: 1272 KDNRDLQKFLQDCQELSLWINEK-MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWL 1330
D+ LQ+ +D ++ WI EK + A + + + KHQA AE+A ++ +
Sbjct: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
Query: 1331 DKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCA 1390
+ ++G ++ E VK KL L++ WE L++ + Q L D+ +A+ +
Sbjct: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
Query: 1391 DLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEG 1450
+ + W+ E + S DYGKD S LLKK + L + + I+ L+ QAQ+ Q+
Sbjct: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960
Query: 1451 KSTDEVDSKRLTVQTKFMELLEP--LNERKHNLLASKEIHQFNRD---VEDEILWVGERM 1505
TD+ K L + + P + +K ++L ++ N+D VE V +R
Sbjct: 961 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTL--LNSTNKDWWKVE-----VNDRQ 1013
Query: 1506 PLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQ 1565
+ + L Q ++N E QG + + I ++ S+S
Sbjct: 1014 GFVPAA-YVKKLDPAQSASRENLL---EEQGSIALRQEQIDNQTRITKEAGSVSL----- 1064
Query: 1566 RLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQ 1625
R+ +++L+ L+E EKR LE++ + + +A E + W++E+E + SEE D +
Sbjct: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
Query: 1626 SAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKV--------- 1676
+ KK ++ ++ + ++K + L ++ E +++Q +V
Sbjct: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDET 1184
Query: 1677 ---------------------------DKLYAGLKDLAEERRGKLDERHRLFQLNREVDD 1709
++ + L+ LAEER L H + + +R+ D+
Sbjct: 1185 DSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADE 1244
Query: 1710 LEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSG 1769
++WI E+ + G D V LQ + F RD +G ++V+++ A+ LI S
Sbjct: 1245 TKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALG-DKVNSLGETAERLIQSH 1303
Query: 1770 HSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQD-KHKKL 1828
A + E LN+AW+ L + D R L S++L +F D +++ I +
Sbjct: 1304 PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
Query: 1829 PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENE 1888
+EL +D E L H +I A + ++ +L A G A K++ +
Sbjct: 1364 SDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLA--HGHYASPEIKQKLD 1421
Query: 1889 VLEAWKSLLDACESRRVRLVDTGDKFRFFSM-VRDLMLWMEDVIRQIEAQEKPRDVSSVE 1947
+L+ ++ L+ +R ++D + + F WM + ++K + SVE
Sbjct: 1422 ILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVE 1481
Query: 1948 LLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWE 2007
L+ H+ I+ + + L+A HYA +I + +R E++D+W
Sbjct: 1482 ALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDI-------SSRRNEVLDRWR 1534
Query: 2008 -------DRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVD-EVEKLI--- 2056
++ L + QFSRD EAW+ + S + ++ KL+
Sbjct: 1535 RLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKH 1594
Query: 2057 KRHEAFE 2063
++H+AFE
Sbjct: 1595 QKHQAFE 1601
Score = 362 bits (930), Expect = 2e-99
Identities = 322/1435 (22%), Positives = 620/1435 (43%), Gaps = 129/1435 (8%)
Query: 924 KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD 983
++I+ ++ ++ R+ +F+EL ++ L + Q + + E + WI+EK ++ ++ +
Sbjct: 13 EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQI--ASDE 70
Query: 984 LGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV 1043
D + +K E ++ A + L + + SE ++ I +RL E+
Sbjct: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 1044 WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQ 1103
WE + ++ + L +A KL Q+LR+ +D W++ + + SE++ L E L +
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 1104 HENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQN 1163
E + ++ +EE ++ + Q Q + + ++ + ++ W L + RQ
Sbjct: 191 FEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL-IKTKQDEVNAAWQRLKGLALQRQG 249
Query: 1164 LLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEE 1223
L + Q+F RD + +++ +E ++A + L +A ++K E + A E+
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
Query: 1224 KINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQD 1283
K+ A+ RL +++ +IQ K + + + R A+E RL D+ LQ+FL D
Sbjct: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
Query: 1284 CQELSLWINEK--MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLI 1341
++L+ W+ E ++ A +++ D A + +HQ E+ ++++ ++ G L+
Sbjct: 370 FRDLTSWVTEMKALINADELASDVA-GAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
Query: 1342 SEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLES 1401
+ V+EKLT L + L + + Q+ +LF + +D W+ E+
Sbjct: 429 AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
Query: 1402 QIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKR 1460
+ ++D G L SV LLKK + E + ++++I L A L Q + ++V ++R
Sbjct: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
Query: 1461 LTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTV 1520
+ ++ L E R+ L S + QF RD ++ WV E+M AT + + +
Sbjct: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-KDPSNL 607
Query: 1521 QLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEE 1580
Q ++K+Q + E+ +Q RID + + Q ++ D + + + + R+ ++ LW L+E
Sbjct: 608 QGKVQKHQAFEAELSANQSRIDALEKAGQKLI-DVNHYAKDEVAARMNEVISLWKKLLEA 666
Query: 1581 TEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQA 1640
TE + +L EA++ QQ+ + + E W+ E E ++ S++ KD + ++ KKH +LE
Sbjct: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
Query: 1641 VEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRL 1700
V + + + ++ +R H ++E I +Q + Y LK+ R+ KL + RL
Sbjct: 727 VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786
Query: 1701 FQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNH 1760
QL R+V+D E WI E+E +A S G+D V L ++ + + + R+ V
Sbjct: 787 QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAG-HEPRIKAVTQ 845
Query: 1761 LADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGR 1820
+ ++ GH A + LN+ W L R Q L S + +++ DA E
Sbjct: 846 KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESW 905
Query: 1821 IQDKHKKLPE-ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDA--ARLQAAYAGD 1877
+++K + + G+D+++ E L + H D+ A G+ ++ L+E A R Q A D
Sbjct: 906 MREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDD 965
Query: 1878 KA---------DDIQKRENEVLEAWKSLLDACESRRVRL--VDTGDKFRFFSMVRDLMLW 1926
+ D +K EV +L S V+ D+ F
Sbjct: 966 ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA------ 1019
Query: 1927 MEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASE 1986
+++++ P +S E L+ I + ++ E G L K E
Sbjct: 1020 ---YVKKLD----PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQV--E 1070
Query: 1987 EIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIG 2046
E+ LL+L EKRK M++K ++ R+A+ + W+ +E L+S E+G
Sbjct: 1071 ELYHSLLELGEKRKGMLEKSCKKF----------MLFREANELQQWINEKEAALTSEEVG 1120
Query: 2047 QSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPS 2106
+++VE L K+ + F+K + R +
Sbjct: 1121 ADLEQVEVLQKKFDDFQKDLKANESRLKDIN----------------------------- 1151
Query: 2107 TKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSP 2166
KV+E+ ES+ GL AE+ + V E+ T SK +SP
Sbjct: 1152 -KVAEDLESE--------------GLMAEE-----VQAVQQQEVYGMMPRDETDSKTASP 1191
Query: 2167 IPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKAS-SRSW--- 2222
S + R+ + + + L HE + ++ A ++ W
Sbjct: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEE 1251
Query: 2223 -----------HNVYCV--INNQEMGFYKD-----------AKTAASGIPYHSEVPVSLK 2258
H++ V + + GF +D +TA I H E L+
Sbjct: 1252 KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQ 1311
Query: 2259 EAVCEVALDYK---KKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAISSDK 2310
E E+ + K+ K +L D ++ D ++ +WI I +SSD+
Sbjct: 1312 EKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE 1366
Score = 297 bits (760), Expect = 9e-80
Identities = 181/542 (33%), Positives = 293/542 (54%), Gaps = 5/542 (0%)
Query: 1559 SAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSE 1618
+AE I++R + + E + R ++LE+++R Q + DA E E W+ E+ L + S+
Sbjct: 11 TAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEK-LQIASD 69
Query: 1619 EKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDK 1678
E KD + L+KHQ E V+ + + +L +T ++++ H SE I R ++ +
Sbjct: 70 ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHR 129
Query: 1679 LYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQE 1738
+ L + E+ KL + +L Q RE +D+ WI ++E + S ELGQD EHV +LQ+
Sbjct: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189
Query: 1739 RFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRT 1798
+F EF D +ERV+ VN A +LI H + I +D +N AW L L R
Sbjct: 190 KFEEFQTDMA-AHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQ 248
Query: 1799 QILAASYELHKFYHDAKEIFGRIQDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALG 1857
L + E+ +F D E I++K + + ++ GRD +V+ L R H E D+ AL
Sbjct: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
Query: 1858 TQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFF 1917
+V+ L +A RLQ ++ A IQ + E++ W+ + R RL D+ RF
Sbjct: 309 DKVKALCAEADRLQQSHPLS-ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFL 367
Query: 1918 SMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL 1977
+ RDL W+ ++ I A E DV+ E L++ HQ K EIDA DSF + E G++L
Sbjct: 368 ADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQAL 427
Query: 1978 LARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQE 2037
LA HYAS+E++EKL L+E+R +++ WE R + +++ F RD + W+ QE
Sbjct: 428 LAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQE 487
Query: 2038 PYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERK 2097
+L + ++G S+D VE L+K+HE FEKS + +E+ +AL+ T +L++ E+
Sbjct: 488 AFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT-KLIQNNHYAMEDVAT 546
Query: 2098 RR 2099
RR
Sbjct: 547 RR 548
Score = 251 bits (641), Expect = 6e-66
Identities = 212/911 (23%), Positives = 417/911 (45%), Gaps = 74/911 (8%)
Query: 1346 ETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQS 1405
ET ++E+ + + + + + Q+L D+ + + F + +L+KW+ + QI S
Sbjct: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE-KLQIAS 68
Query: 1406 DDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT 1465
D+ KD T++ L+K Q E +++ I +L + EG E T++T
Sbjct: 69 DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASE------TIRT 122
Query: 1466 KFME-------LLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQ 1518
+ ME LLE + E+ LL ++++ Q+ R+ ED + W+ ++ + TS + G +L+
Sbjct: 123 RLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLE 182
Query: 1519 TVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLI 1578
V++L KK + Q ++ H+ R++++ + + ++ + E I+ + ++ W L
Sbjct: 183 HVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP-EEELIKTKQDEVNAAWQRLK 241
Query: 1579 EETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILE 1638
+R +L A Q++ D E +W+ E+E M S++ +D S ++L+KH+ LE
Sbjct: 242 GLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLE 301
Query: 1639 QAVEDYAETVHQLSKTSRALVADSHP-ESERISMRQSKVDKLYAGLKDLAEERRGKLDER 1697
+ + + V L + L SHP + +I +++ ++ + ++ LA ER +L++
Sbjct: 302 RDLAALEDKVKALCAEADRL-QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
Query: 1698 HRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDT 1757
+RL + + DL W+ E + + + EL D L +R +E + + ++ +
Sbjct: 361 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEI-DAHEDSFKS 419
Query: 1758 VNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEI 1817
+ L+ +GH + + E L+E A LLEL + R Q +L FY D +++
Sbjct: 420 ADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQV 479
Query: 1818 FGRIQDKHK-KLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL--QAAY 1874
+ + L E+LG ++VE L + H FE + A ++ L E A +L Y
Sbjct: 480 DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHY 539
Query: 1875 AGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQI 1934
A +D+ R + +L +L + RR +L D+ +FF +L W+ + ++
Sbjct: 540 A---MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-T 595
Query: 1935 EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQ 1994
E +D S+++ + HQ +AE+ A + G+ L+ HYA +E+ ++ +
Sbjct: 596 ATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNE 655
Query: 1995 LTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEK 2054
+ K++++ E + LR + QF+R+ E WL E +L+S + G+ + V+
Sbjct: 656 VISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQN 715
Query: 2055 LIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAE 2114
L K+H E A +R + ++ R+ Q+ +E +
Sbjct: 716 LQKKHALLEADVAAHQDRIDGI-------TIQARQFQDAGHFD------------AENIK 756
Query: 2115 SQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSD- 2173
+Q+ ++ E + + P ++A+++ ++ ++ T +E PI + T+
Sbjct: 757 KKQEALVARYEALKE---PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG 813
Query: 2174 ---------RKAKTALPAQSAATLP---ARTQETPSAQMEGF------------LNRKHE 2209
K AL A+ A P A TQ+ + EG LN+K
Sbjct: 814 KDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQK-- 871
Query: 2210 WEAHNKKASSR 2220
WEA KAS R
Sbjct: 872 WEALKAKASQR 882
Score = 98.2 bits (243), Expect = 8e-20
Identities = 128/611 (20%), Positives = 244/611 (39%), Gaps = 86/611 (14%)
Query: 277 FSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVG 336
F K+K++A + E+ ++ + + + D WI++ +++ + + L G
Sbjct: 1751 FQKIKSMAASRRA------KLNESHRLHQFFRDM-DDEESWIKEKKLLVGSEDYGRDLTG 1803
Query: 337 VQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPRE-GKLISDIN-- 393
VQ NL +++++ A+ + + GK +SD N
Sbjct: 1804 VQ----------------------NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTI 1841
Query: 394 ---KAWERLEK-AEHEREL----ALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLV 445
+ +RL + EH +EL A R + + +E LE ++F E W++E LV
Sbjct: 1842 GKEEIQQRLAQFVEHWKELKQLAAARGQRL-EESLEY--QQFVANVEEEEAWINEKMTLV 1898
Query: 446 SQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDN 505
+ +++G L A++ KKHEA ETD +++RV V ++L +N H + I+++
Sbjct: 1899 ASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKG 1958
Query: 506 VIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVED 565
+ L + R+ +L+ N + + + W+ E + + + DYG+ L V+
Sbjct: 1959 LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQT 2018
Query: 566 LLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ 625
LL K +A G+QA + G+ A+ K + I R A + + +L
Sbjct: 2019 LLTKQETFDA--GLQAFQQEGI-ANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLA 2075
Query: 626 LAAERRARLEES----RRLWKFFWEMAEE----EGWIREKEKILSSDDYGKDLTSVMRLL 677
+A R+ +L E+ R++ F A++ W E+ L+ L + L
Sbjct: 2076 NSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALR 2135
Query: 678 SKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRK 737
H AF +S F Q + + + + + + E W NL+++ R+
Sbjct: 2136 EAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERE 2195
Query: 738 KRL--------EEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDV 789
L E L +F A+ W+ + T++ + +
Sbjct: 2196 LELQKEQRRQEENDKLRQEFAQHANAFHQWIQE----------------TRTYLLDGSCM 2239
Query: 790 AEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRL-RKQALQDT 848
EE TL Q A ++H E +R +L IE+ + E L K T
Sbjct: 2240 VEESG-------TLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHST 2292
Query: 849 LALYKMFSEAD 859
+ L + + + D
Sbjct: 2293 VGLAQQWDQLD 2303
Score = 47.8 bits (112), Expect = 1e-04
Identities = 61/296 (20%), Positives = 119/296 (40%), Gaps = 18/296 (6%)
Query: 241 AEQHLGLTKLLDPED--ISVDHPDEKSIITYVVTYYHYFSKMKA-LAVEGKRIGKVLDNA 297
A Q G+ + +D ++ H K+I + +S++ A A K++ + +
Sbjct: 2032 AFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2091
Query: 298 IETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFT 357
+ E + + AS W E L + NSL ++ +A + +R+ +
Sbjct: 2092 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQ-A 2150
Query: 358 EKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQ 417
+ L L I+S A+N + E + + W L+K EREL L+ E RQ
Sbjct: 2151 DFNQLAELDRQIKSFRVASNPYTWFTMEA-----LEETWRNLQKIIKERELELQKEQRRQ 2205
Query: 418 EKLEQLARRFDRKAAMRETWLSENQRLVSQ-----DNFGFDLPAVEAATKKHEAIETDIA 472
E+ ++L + F + A W+ E + + + G +EA +KH+ +I
Sbjct: 2206 EENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ----EIR 2261
Query: 473 AYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNL 528
A +++ + + +E D K + + W+ L +L + LE +
Sbjct: 2262 AMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQI 2317
>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
Length = 2419
Score = 570 bits (1470), Expect = e-162
Identities = 386/1457 (26%), Positives = 698/1457 (47%), Gaps = 82/1457 (5%)
Query: 712 SEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 771
+E+I+ER + ++ + ++ A R ++LE++ L F+ DADD+ W+++ + I++
Sbjct: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKS 80
Query: 772 VGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHE-QASALPQEHAESPDVRGRLSGIEER 830
D + Q +KH+ + E+ + L + + H+ + + + +
Sbjct: 81 Y-EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHL 139
Query: 831 YKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHR 890
+ + ELT + L L + E WI +KE ++++ E E EV+ +
Sbjct: 140 WDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKK 199
Query: 891 FESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDA 950
FE + E+ + RV VNQ A + HP I+++Q+++N W + R L +++ A
Sbjct: 200 FEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKA 259
Query: 951 LLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEA 1010
L +A ++Q + + E WI+EK V+ S +D G DL L G+ER+L +
Sbjct: 260 LSNAANLQRFKRDVTEAIQWIKEKEPVLTS-EDYGKDLVASEGLFHSHKGLERNLAVMSD 318
Query: 1011 KLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRD 1070
K+ +L +AEKL HP A I ++ WE ++ +R L +F D
Sbjct: 319 KVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSD 378
Query: 1071 LDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQ 1130
D+ W++ AI ++++P + E LL +H+ K+EID+Y++ +Q + G+ +
Sbjct: 379 FDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN 438
Query: 1131 GQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEY 1190
+A +R++++ LD W L ++W+ R Q + F RD++Q +++++ QE
Sbjct: 439 ANHEASDE-VREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEA 497
Query: 1191 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1250
L + ++ +L AEA ++K EDF A EEKI V +T +L+ D + +S+ I+
Sbjct: 498 FLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIR 557
Query: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1310
D + R RE A+ LK++ LQK +D +L WIN+K A D Y + +NL
Sbjct: 558 DGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLK 617
Query: 1311 SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ 1370
S+ K Q F ELA NK L+ I+K G ++I V +L+ + +WE L T+
Sbjct: 618 SRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATK 677
Query: 1371 TKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQME 1430
K +L +AN+ F + DL +WL +E Q+ S+DYGK L V L+K +LE+ +
Sbjct: 678 QKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVA 737
Query: 1431 VRKKEIEELQSQAQALSQEG-KSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQ 1489
R+ +++ L A + G + ++ +++ ++ +F L EPL RK LL +
Sbjct: 738 ARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQL 797
Query: 1490 FNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQ 1549
RD EDE W+ E P ATST G +L + L+ +++ + + I H+PRI +I ER
Sbjct: 798 ICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGN 857
Query: 1550 NIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMS 1609
+V + +AE + R+ L Q L +R LE + QQY D EAE W+
Sbjct: 858 KMV-EEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIR 916
Query: 1610 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRA------------ 1657
E+E + + DE++A ++LKKH+ + + +++ L + A
Sbjct: 917 EKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGV 976
Query: 1658 -------LVADSHPESER-ISMRQSKVDKLYAGL---------------------KDLAE 1688
+ D S R ++M++ V L + + + LA
Sbjct: 977 AGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAH 1036
Query: 1689 ERRGKLDERHR-----LFQLNREVDDLEQWIAE------REVVAGSHELGQDYEHVTMLQ 1737
+ L +R R + Q ++++ + + + R ++ +E YE ML+
Sbjct: 1037 DEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLE 1096
Query: 1738 ERFREFARDTG--------------------NIGQERVDTVNHLADELINSGHSDAATIA 1777
+ A +TG N + R+ +N +AD+L+ G A
Sbjct: 1097 WIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEG-A 1155
Query: 1778 EWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQ 1836
+ + LN W L L D + Q+L +++ + F+ +A + +I+ K + L + G D
Sbjct: 1156 QIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDL 1215
Query: 1837 NTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSL 1896
+V+ LQR H FE D+ LG +V L E A RL ++ D +D+Q+++ E+ EAW+ L
Sbjct: 1216 FSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHP-DATEDLQRQKMELNEAWEDL 1274
Query: 1897 LDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGI 1956
+ R+ L + + F S RDL W+ + + +QE D++ +E+L+ HQ
Sbjct: 1275 QGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEH 1334
Query: 1957 KAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLI 2016
+A+++A +F + L+ H+AS EI++KL + +R ++ WE R + L
Sbjct: 1335 RADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQC 1394
Query: 2017 LEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL 2076
LE+ F + E+W++ +E L S + S+D +E L+K+ + +K+ + + + L
Sbjct: 1395 LELQMFQGNCDQVESWMVARENSLRSDD-KSSLDSLEALMKKRDDLDKAITAQEGKITDL 1453
Query: 2077 ERLTTLELLEVRRQQEE 2093
E + + +EE
Sbjct: 1454 EHFAESLIADEHYAKEE 1470
Score = 442 bits (1136), Expect = e-123
Identities = 413/1945 (21%), Positives = 851/1945 (43%), Gaps = 113/1945 (5%)
Query: 298 IETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFT 357
+E ++ ++ A DL +WI + + IL ++ + + +Q K+
Sbjct: 49 LEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPT-----NIQG-----------KYQ 92
Query: 358 EKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQ 417
+ +LE + T +S++ + +K R S + +E+ H +L L L
Sbjct: 93 KHQSLEAEVQT-KSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTL--- 148
Query: 418 EKLEQLARRFDRKAAMRET-----WLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIA 472
EK +QL R + ++E W+ + + + + G D E KK E + ++
Sbjct: 149 EKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELV 208
Query: 473 AYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQK 532
A E RV V A E EN+ D+ I ++++ V WE L L R++ L LQ+
Sbjct: 209 AKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQR 268
Query: 533 IFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQ 592
+++ + W+ E + ++ S+DYGK L+ E L H +E ++ + +++V+ + A A+
Sbjct: 269 FKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAE 328
Query: 593 KFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEG 652
K P D I++ + ++ + LA R +L+ + +F + E G
Sbjct: 329 KLTLS----HPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSG 384
Query: 653 WIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGS 712
W+ EK +++D+ D+ LL +H+ + E+ F+ A + G+D++ H S
Sbjct: 385 WMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEAS 444
Query: 713 EKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDV 772
+++RE++ + W L +L R ++ E+ H F D++ +D+WM + + D+
Sbjct: 445 DEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDL 504
Query: 773 GHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERY 831
G+ S ++L++KH+D E + T+ + A+ L +H +S +++ G+ R
Sbjct: 505 GNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARR 564
Query: 832 KEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF 891
+ E R++ L+++L L K++ ++D + WI++K++ ++ E +D++ ++ R
Sbjct: 565 DALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADD----EDYKDIQNLKSRV 620
Query: 892 ES---LEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKK 948
+ E E+ +++ + + ++++ GH + + + ++ + W + E +K
Sbjct: 621 QKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKG 680
Query: 949 DALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAI 1008
L A + + + W+ + + S +D G LA V RK +E + A
Sbjct: 681 TQLHEANQQLQFENNAEDLQRWLEDVEWQVTS-EDYGKGLAEVQNRLRKHGLLESAVAAR 739
Query: 1009 EAKLSDLQKEAEKLES-EHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQF 1067
+ ++ L A E HPD ++ I +R + +E +K L R+ L + LQ
Sbjct: 740 QDQVDILTDLAAYFEEIGHPD-SKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLI 798
Query: 1068 LRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG-E 1126
RD +D ++W+ T+ + S + L ++KLL +H I I ++E Q++ + G +
Sbjct: 799 CRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNK 858
Query: 1127 MVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLN 1186
MV +G A+ + R+++L+ L RQN L + +QQ+L D +AE ++
Sbjct: 859 MVEEGHFAAE--DVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIR 916
Query: 1187 NQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRI 1246
+E ++ +T E A A +KK E F+ +N+ ++ + L + N +
Sbjct: 917 EKEPIVDNTNYGADEEAAGALLKKHEAFLL-------DLNSFGDSMKALRNQANACQQQQ 969
Query: 1247 QEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEA 1306
V+ + R +M L D + + +E+++ + + ++ D
Sbjct: 970 AAPVEGVAGEQR---------VMALYDFQ-----ARSPREVTMKKGDVLTLLSSINKD-- 1013
Query: 1307 RNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETE-AVVKEKLTGLHKMWEVL 1365
W K +A + ++ ++ + ++ ++ E + ++ + + L
Sbjct: 1014 ------WWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSL 1067
Query: 1366 ESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQML 1425
+ + +RL L D+ +W+ + ++++ G +L V L KK
Sbjct: 1068 LDRAEERRRRLLQRYNEFLLAYEAGDMLEWI----QEKKAENTGVELDDVWELQKKFDEF 1123
Query: 1426 ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASK 1485
+ + + + ++ A L EG T E R + +++ L +E++ L ++
Sbjct: 1124 QKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAH 1183
Query: 1486 EIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIF 1545
+ F+R+ +D + ++ ++ D G +L +VQ L ++++ ++++ ++ +
Sbjct: 1184 AVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILG 1243
Query: 1546 ERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAE 1605
E ++ + ++S + E ++++ +L + W L T+ R L EA + + A + +
Sbjct: 1244 ETAERL-SESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQ 1302
Query: 1606 AWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPE 1665
W+S + S+E A+D +L++HQ +E A T L S L+ H
Sbjct: 1303 NWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHA 1362
Query: 1666 SERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHE 1725
S I + V L+ E+R+ LD+ L D +E W+ RE S +
Sbjct: 1363 SPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDD 1422
Query: 1726 LGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNE 1785
++++R T G ++ + H A+ LI H IA + +
Sbjct: 1423 KSSLDSLEALMKKRDDLDKAITAQEG--KITDLEHFAESLIADEHYAKEEIATRLQRVLD 1480
Query: 1786 AWADL-LELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQR 1844
W L +LID RT+ L L +FY D +E+ I + +E +D ++
Sbjct: 1481 RWKALKAQLIDERTK-LGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYL 1539
Query: 1845 MHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVL-EAWKSLLDACESR 1903
H TF H++ QV + L A D ++ K + E L E W LL+ +
Sbjct: 1540 KHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDK 1599
Query: 1904 RVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDAR 1963
+L + + RF + +RD W+ + + +++ RD++S L+ HQ ++ E+ AR
Sbjct: 1600 GKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAR 1659
Query: 1964 NDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFS 2023
D+ L + LL+ + ++I +K + ++ + + E L+ + QF
Sbjct: 1660 EDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFF 1719
Query: 2024 RDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLE 2083
+D E+W+ + +SS++ G+ + V+ L+K+H+ E + + L E
Sbjct: 1720 QDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNV--LDMAE 1777
Query: 2084 LLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAE 2143
L+ + +EE + R A+ + W+ K E GL ++ E
Sbjct: 1778 KLKDKAAVGQEEIQLR------------LAQFVEHWEKLK-ELAKARGL-------KLEE 1817
Query: 2144 TVDTSEMVNGATEQRT--SSKESSPIPSPTSDRKAKT--ALPAQSAATLPARTQET---- 2195
+++ + + A E+ + K + + D A T L A ET
Sbjct: 1818 SLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQN 1877
Query: 2196 PSAQMEGFLNRKHEWEAHNKKASSR 2220
AQ E LN+ + E+ NK+ SS+
Sbjct: 1878 VCAQGEDILNKVLQEESQNKEISSK 1902
Score = 432 bits (1111), Expect = e-120
Identities = 417/1995 (20%), Positives = 866/1995 (43%), Gaps = 184/1995 (9%)
Query: 259 DHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWI 318
+HPD I + + +++ LA++ + K L NA +++++ ++ ++WI
Sbjct: 228 NHPDLPLIQSKQNEVNAAWERLRGLALQRQ---KALSNAAN----LQRFKRDVTEAIQWI 280
Query: 319 EQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQ 378
++ +L + + LV + F++++ +E+ NL V+ ++ ++ A +
Sbjct: 281 KEKEPVLTSEDYGKDLVASEG---LFHSHKGLER--------NLAVMSDKVK-ELCAKAE 328
Query: 379 KVYM------PREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLA--RRFDRK 430
K+ + P+ ++ D+ +WE H R LA R EKL+ RF
Sbjct: 329 KLTLSHPSDAPQIQEMKEDLVSSWE------HIRALATS----RYEKLQATYWYHRFSSD 378
Query: 431 AAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEA 490
W++E ++ D D+ E +H+ + +I +Y++R Q+ ++L
Sbjct: 379 FDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN 438
Query: 491 ENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVL 550
N+ + + + + W LLEL R ++ E L +++ + WM +
Sbjct: 439 ANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAF 498
Query: 551 VLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIR 610
+ ++D G L E LLQKH E Q E++ V+ +A K D + Y + + IR
Sbjct: 499 LENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGD-DHYDSENIKAIR 557
Query: 611 DRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDL 670
D + +E AA RR L+ES L K + + + + WI +K+K+ +DY KD+
Sbjct: 558 DGLLARRDALREK---AATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDY-KDI 613
Query: 671 TSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLE 730
++ + K + FE E++ E K G++MI H+ S+ + R+ + W L
Sbjct: 614 QNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELL 673
Query: 731 QLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVA 790
+ + + +L EA+ QF+ +A+D+ W+ D+ V+S D G Q+ ++KH +
Sbjct: 674 EATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLE 733
Query: 791 EEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTL 849
+A + +D L + A+ + H +S D+R R + R++ + E RK+ L D L
Sbjct: 734 SAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLL 793
Query: 850 ALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVN 909
L + + + E WI E E + + + L + + +R + + + R+ +
Sbjct: 794 HLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEIT 853
Query: 910 QIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKS 969
+ +++ GH + +++ ++ LN R R+++ L + + Q Y + +E ++
Sbjct: 854 ERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAET 913
Query: 970 WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQ 1029
WIREK ++++T + G D AL +K DL + + L+ +A + +
Sbjct: 914 WIREKEPIVDNT-NYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAP 972
Query: 1030 AQAI---------------------------LSRLAEISDVW------------------ 1044
+ + L+ L+ I+ W
Sbjct: 973 VEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVR 1032
Query: 1045 ----EEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQT--------------AIA 1086
+E + R G ++ Q+ + + ++S L R + A
Sbjct: 1033 RLAHDEFPMLPQRRREEPGNITQRQEQIEN--QYRSLLDRAEERRRRLLQRYNEFLLAYE 1090
Query: 1087 SEDMPNTLTEAEKLLTQHE-----NIKNEIDNYEEDYQ----KMRDMG----EMVTQGQT 1133
+ DM + E + T E ++ + D +++D ++RD+ +++ +G
Sbjct: 1091 AGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLL 1150
Query: 1134 DAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA 1193
+ +RQ L ++ W L ++ + ++ LL +HA + F R+ + + + L+
Sbjct: 1151 TPEGAQIRQEL---NSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALS 1207
Query: 1194 HTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSI 1253
+ + L +A ++ E F + +K+ + ET RL ++ +Q + +
Sbjct: 1208 AADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMEL 1267
Query: 1254 DDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINE--KMLTAQDMSYDEARNLHS 1311
++ + + L + + FL ++L WI+ M+++Q+++ D +
Sbjct: 1268 NEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAED-LTGIEI 1326
Query: 1312 KWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQT 1371
+HQ A++ + +E +LI +++KL + + LE +
Sbjct: 1327 LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEK 1386
Query: 1372 KAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEV 1431
+ + L + ++F +C ++ W+ E+ ++SDD L S+ L+KK+ L+ +
Sbjct: 1387 RKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSS-LDSLEALMKKRDDLDKAITA 1445
Query: 1432 RKKEIEELQSQAQAL-SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQF 1490
++ +I +L+ A++L + E + +E+ ++ V ++ L L + + L + QF
Sbjct: 1446 QEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQF 1505
Query: 1491 NRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQN 1550
RD+E+ W+ E +P A + + +Q K+QT E+ G ++ + +
Sbjct: 1506 YRDLEELEEWISEMLPTACDESY-KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNS 1564
Query: 1551 IVTDSS-SLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMS 1609
++ S+ + EA++++L LK+ W L+E T + ++L EA R Q++ + E W+S
Sbjct: 1565 LIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLS 1624
Query: 1610 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669
E E + +++A+D SA ++LKKHQ+LE+ + + + L+ + L++ ++I
Sbjct: 1625 EAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQI 1684
Query: 1670 SMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQD 1729
++ V+K + +++LA KL E + LFQ +++DD E WI E+ + S + G+D
Sbjct: 1685 VKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRD 1744
Query: 1730 YEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLN----- 1784
+ V L ++ + + + + V +A++L D A + + + L
Sbjct: 1745 LQGVQNLLKKHKRLEGEL-VAHEPAIQNVLDMAEKL-----KDKAAVGQEEIQLRLAQFV 1798
Query: 1785 EAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHK-KLPEELGRDQNTVETLQ 1843
E W L EL R L S E +F +A+E I +K+ + + G ++L
Sbjct: 1799 EHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLL 1858
Query: 1844 RMHTTFEHDIQALGTQVRQL--QEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACE 1901
H E+D T+V+ + Q + + + +I + + E SL A
Sbjct: 1859 MKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIA 1918
Query: 1902 SRRVRLVDTGDKFRFFSMVRDLM-LWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEI 1960
+ +++L D F+ F+ D++ W+ D ++ D+ L+ + A +
Sbjct: 1919 AWKLQLED-DYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASL 1977
Query: 1961 DA-RNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMID-KWEDRWEWLRLILE 2018
+ + + +L L++ +H S+ I+E+ L ++ +++++ R + L L
Sbjct: 1978 QSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLP 2037
Query: 2019 VH-------QFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDE 2071
+ +F+ AS W E LS S++E+ +L K HE F S A
Sbjct: 2038 LQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQA 2097
Query: 2072 RFSALERL----------------TTLELL-----------EVRRQQEEEERKRRPPSPE 2104
F L L T+E+L E R Q+ ++E R+ + E
Sbjct: 2098 DFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFE 2157
Query: 2105 PSTKVSEEAESQQQW 2119
+ + A + QW
Sbjct: 2158 MCQEFEQNASTFLQW 2172
Score = 326 bits (836), Expect = 1e-88
Identities = 355/1730 (20%), Positives = 734/1730 (42%), Gaps = 155/1730 (8%)
Query: 40 FERSRIKALAD----EREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVL 95
++ IKA+ D R+A+++K T+ L + S + LY D D + I + L
Sbjct: 548 YDSENIKAIRDGLLARRDALREKAATR---RRLLKESLLLQKLYEDSDDLKNWINKKKKL 604
Query: 96 SGERLPKPTKG-RMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNH--------RLT 146
+ + K + + R+ + +K L K Q +++ G ++++G H RL+
Sbjct: 605 ADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQ-EMIEGGHYASDNVTTRLS 663
Query: 147 -LGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDG 205
+ +W +L Q + E N++ + +A L W +
Sbjct: 664 EVASLWEELLEATKQKGTQLHEANQQLQFENNAEDL------------------QRWLED 705
Query: 206 MAFNALIHKHRPDLIDF-DKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEK 264
+ + + L + ++L+K H L++A + + + L + HPD K
Sbjct: 706 VEWQVTSEDYGKGLAEVQNRLRK---HGLLESAVAARQDQVDILTDLAAYFEEIGHPDSK 762
Query: 265 SIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIII 324
I + F +K K+ K+LD + + + E D WI++T
Sbjct: 763 DIRARQESLVCRFEALKEPLATRKK--KLLD-LLHLQLICRDTE----DEEAWIQETEPS 815
Query: 325 LNNRKFANSLVGVQQQLQAFNTYRTV--------EKPPKFTEKGNLEVLLFTIQSKMRAN 376
+ L+ ++ L N +R + + + TE+GN V ++ A+
Sbjct: 816 ATSTYLGKDLIASKKLL---NRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVAS 872
Query: 377 NQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRET 436
K +N+ E L R+ L + Q+ L L ET
Sbjct: 873 RVK-----------SLNQNMESLRARAARRQNDLEANVQFQQYLADLHEA--------ET 913
Query: 437 WLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDI 496
W+ E + +V N+G D A A KKHEA D+ ++ + ++A+ A + + +
Sbjct: 914 WIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPV 973
Query: 497 KRITARKDNVIRLWEYLLELLRARRQR-LEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQD 555
+ + A + V+ L+++ +AR R + M G ++L ++ +++ V + D
Sbjct: 974 EGV-AGEQRVMALYDF-----QARSPREVTMKKG------DVLTLLSSINKDWWKVEAAD 1021
Query: 556 YGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAH 615
+ G+ + L + + +R R +P I R
Sbjct: 1022 HQ----GIVPAVYVRRLAHDEFPMLPQRRRE------------------EPGNITQRQEQ 1059
Query: 616 MEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMR 675
+E Y+ L A ERR RL + + +E + WI+EK+ +++ G +L V
Sbjct: 1060 IENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK----AENTGVELDDVWE 1115
Query: 676 LLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSE--KIRERIIYIREQWANLEQLS 733
L K F+ +++ K +D++ E E +IR+ + +W +L++L+
Sbjct: 1116 LQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE---LNSRWGSLQRLA 1172
Query: 734 AIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEI 793
+++ L A + F +ADD + + +S++D G D +S Q+L ++H+ ++
Sbjct: 1173 DEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDL 1232
Query: 794 ANYRPTLDTLHEQASALPQEHAE-SPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALY 852
+ L E A L + H + + D++ + + E ++++ T+ RK++L + Y
Sbjct: 1233 VPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFY 1292
Query: 853 KMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIA 912
S+A + WI +++ ++ E L +E++ R + +M +A + +
Sbjct: 1293 LFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFS 1352
Query: 913 RQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIR 972
+L+ SGH + EI+ + + + +++K L L +Q + C++ +SW+
Sbjct: 1353 AELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMV 1412
Query: 973 EKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQA 1032
+ + S D + L + AL +K +++ + A E K++DL+ AE L ++ +
Sbjct: 1413 ARENSLRS--DDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEE 1470
Query: 1033 ILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPN 1092
I +RL + D W+ +K L + LG+ + L+QF RDL++ + W+S E +
Sbjct: 1471 IATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKD 1530
Query: 1093 TLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG-EMVTQGQTDAQYMFLRQRLQALDTGW 1151
T ++ +H+ +E+D E + ++G ++ D ++++L+ L W
Sbjct: 1531 A-TNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHW 1589
Query: 1152 NELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQ 1211
+ L + ++ L+++ Q+F + E +L+ E +LA + L A +KK
Sbjct: 1590 DHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKH 1649
Query: 1212 EDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRL 1271
+ M A E+ + + L+S G N D+I +K D+++ R +E A+ +L
Sbjct: 1650 QLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKL 1709
Query: 1272 KDNRDLQKFLQDCQELSLWINEKMLTAQDMSYD-EARNLHSKWLKHQAFMAELASNKEWL 1330
K+ L +F QD + WI EK++ Y + + + + KH+ EL +++ +
Sbjct: 1710 KEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAI 1769
Query: 1331 DKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCA 1390
+ +L + + ++ +L + WE L+ + + +L ++ + F Q+
Sbjct: 1770 QNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829
Query: 1391 DLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQ----AL 1446
+ + W++ + D G L + LL K + LEN V + ++ + +Q + +
Sbjct: 1830 EEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKV 1889
Query: 1447 SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMP 1506
QE E+ SK + K L + + K L +FN + W+ ++
Sbjct: 1890 LQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKET 1949
Query: 1507 LATSTDHGHNLQTVQLLIKKNQTLQKEIQG-HQPRIDDIFERSQNIVTDSSSLSAEAIRQ 1565
+ +G +L L+ K TL +Q Q R+ +I + +++ + S +AI +
Sbjct: 1950 SLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQS-KAIEE 2008
Query: 1566 RLADLKQLWGLLIEETEKRHRRLEE----AHRAQQYYFDAAEAEAWMSEQELYMMSEEKA 1621
R A L + W L+E + ++L E +A+ + + A + ++ M EE
Sbjct: 2009 RYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKM--EENL 2066
Query: 1622 KDEQSAVSMLKKHQILEQAVEDYAETVHQ-------LSKTSRALVADSHPESERISMRQS 1674
+ VS+ + Q L++ ED+ ++ + L + + + A P S +
Sbjct: 2067 SEPVHCVSLNEIRQ-LQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVE 2125
Query: 1675 KVDKLYAGLKDLAEERRGKLDERH----RLFQLNREVDD----LEQWIAE 1716
+++ + L D+ EER +L + + F++ +E + QWI E
Sbjct: 2126 VLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILE 2175
Score = 324 bits (830), Expect = 7e-88
Identities = 335/1653 (20%), Positives = 685/1653 (41%), Gaps = 86/1653 (5%)
Query: 497 KRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 556
+ I R+ V+ ++ E + R Q+LE + LQ ++ + W+ E KV +L+
Sbjct: 22 EEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIME-KVNILTDKS 80
Query: 557 GKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHM 616
+ ++ QKH +EA++ ++ + + + ++ T G + + + +
Sbjct: 81 YEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAH----EETKAHIEEL 136
Query: 617 EFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRL 676
+ L +L E+ +L + + ++ E A+ WI +KE I +S + G+D L
Sbjct: 137 RHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVL 196
Query: 677 LSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIR 736
K F+ E+ + G + + + E H I+ + + W L L+ R
Sbjct: 197 HKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQR 256
Query: 737 KKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANY 796
+K L A+ L +F+ D + W+ + +++S D G D +++ L HK + +A
Sbjct: 257 QKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVM 316
Query: 797 RPTLDTLHEQASALPQEH-AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMF 855
+ L +A L H +++P ++ + ++ + L R + LQ T ++
Sbjct: 317 SDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFS 376
Query: 856 SEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQL 915
S+ D W++EK +N ++P + EV+ R + + E+++ R ++ + L
Sbjct: 377 SDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDL 436
Query: 916 MHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKT 975
+++ H + E++ + + L+ W+ EL D + L ++ + + SW+ +
Sbjct: 437 VNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQE 496
Query: 976 KVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL-ESEHPD--QAQA 1032
+E+ +DLGN L AL +K E A E K+ + K A KL +H D +A
Sbjct: 497 AFLEN-EDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA 555
Query: 1033 ILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASE---D 1089
I L D E T R L E+ LQ+ D DD ++W+++ + E D
Sbjct: 556 IRDGLLARRDALREKAAT---RRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKD 612
Query: 1090 MPNTLTEAEKLLTQHENI---KNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQA 1146
+ N + +K + + K +++N ++ Q+M + G + T RL
Sbjct: 613 IQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVT--------TRLSE 664
Query: 1147 LDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEA 1206
+ + W EL + + + L +++ QF + + + +L + E+ + + L +
Sbjct: 665 VASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQN 724
Query: 1207 AIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASE 1266
++K + + A +++++ + + G+ +S I+ + +S+ R +E +
Sbjct: 725 RLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLAT 784
Query: 1267 LLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWL-KHQAFMAELAS 1325
+L D LQ +D ++ WI E +A + K L +H+ + +AS
Sbjct: 785 RKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIAS 844
Query: 1326 NKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELF 1385
++ + +I + G +++ E V ++ L+ + +ES A+R D F
Sbjct: 845 HEPRIQEITERGNKMVEEGHFAAEDVASRVKSLN---QNMESLRARAARRQNDLEANVQF 901
Query: 1386 TQSCADL---DKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ 1442
Q ADL + W+ E + + +YG D + LLKK + + ++ L++Q
Sbjct: 902 QQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQ 961
Query: 1443 AQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVG 1502
A A Q+ + E + + + M L + + +E+ DV + +
Sbjct: 962 ANACQQQQAAPVE----GVAGEQRVMALYD------FQARSPREVTMKKGDVLTLLSSIN 1011
Query: 1503 ERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA 1562
+ + DH + V + + Q + +I +R + I S
Sbjct: 1012 KDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRS----- 1066
Query: 1563 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1622
L++ E+R RRL + + ++A + W+ E++ +E
Sbjct: 1067 --------------LLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK----AENTGV 1108
Query: 1623 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAG 1682
+ + KK ++ + + ++K + L+ + E +RQ +++ +
Sbjct: 1109 ELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQ-ELNSRWGS 1167
Query: 1683 LKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFRE 1742
L+ LA+E+R L H + +RE DD ++ I ++ + + G D V LQ R
Sbjct: 1168 LQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEG 1227
Query: 1743 FARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILA 1802
F RD +G ++V + A+ L S + K LNEAW DL R + L
Sbjct: 1228 FERDLVPLG-DKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLN 1286
Query: 1803 ASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVR 1861
+ + + F A+++ I + +EL D +E L H D++A +
Sbjct: 1287 EAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQ 1346
Query: 1862 QLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVR 1921
L++ +A L +G A +++ + ++ + L+ +R +++D + + F
Sbjct: 1347 ALEDFSAEL--IDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNC 1404
Query: 1922 D-LMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR 1980
D + WM + + +K + S+E LM + I A+ T +SL+A
Sbjct: 1405 DQVESWMVARENSLRSDDK-SSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIAD 1463
Query: 1981 KHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL 2040
+HYA EEI +L ++ ++ K + + D L + QF RD E W+ P
Sbjct: 1464 EHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLP-T 1522
Query: 2041 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTL-----------ELLEVRR 2089
+ E + +++ +H+ F E+ + L E ++ +
Sbjct: 1523 ACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQL 1582
Query: 2090 QQEEEERKRRPPSPEPSTKVSEEAESQQQWDTS 2122
+Q +E K EA QQ+++TS
Sbjct: 1583 EQLKEHWDHLLERTNDKGKKLNEASRQQRFNTS 1615
Score = 322 bits (826), Expect = 2e-87
Identities = 304/1384 (21%), Positives = 590/1384 (42%), Gaps = 125/1384 (9%)
Query: 801 DTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADA 860
+T+ E + E AE +++ R + RY+ E R Q L+D+ L +AD
Sbjct: 7 ETVVESSGPKVLETAE--EIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD 64
Query: 861 CELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPEMNNQASRVAVVNQIARQLMH 917
WI EK N+ + ED IQ ++ +SLE E+ ++ ++ + + +
Sbjct: 65 LGKWIMEKV----NILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFT 120
Query: 918 SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKV 977
GH + +E KA ++L W EL K D LL AL Q Y EC + WI +K +
Sbjct: 121 MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDK-EA 179
Query: 978 IESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEA-EKLESEHPDQAQAILSR 1036
I ++ +LG D L +K + +LVA E ++ ++ + A E E HPD I S+
Sbjct: 180 IATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPD-LPLIQSK 238
Query: 1037 LAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTE 1096
E++ WE ++ R+ +L A+ LQ+F RD+ + W+ + + SED L
Sbjct: 239 QNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVA 298
Query: 1097 AEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQ-TDAQYMFLRQRLQALDTGWNELH 1155
+E L H+ ++ + + +++ E +T +DA +++ + L + W +
Sbjct: 299 SEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQ--IQEMKEDLVSSWEHIR 356
Query: 1156 KMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFM 1215
+ +R L ++ Y +F D + ++N + + E+PT + G E + + +
Sbjct: 357 ALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHK 416
Query: 1216 TTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNR 1275
+D+ +++ + ETG+ LV+ + SD ++EK++ +D+ E E + +
Sbjct: 417 HEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCL 476
Query: 1276 DLQKFLQDCQELSLWIN--EKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKI 1333
D F +D +++ W++ E L +D+ + + + KH+ F + +E + +
Sbjct: 477 DFHLFYRDSEQVDSWMSRQEAFLENEDLG-NSLGSAEALLQKHEDFEEAFTAQEEKIITV 535
Query: 1334 EKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLD 1393
+K +LI + +K GL + L T+ + L ++ + + DL
Sbjct: 536 DKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLK 595
Query: 1394 KWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-S 1452
W++ + +DY KD+ ++ ++KQQ+ E ++ V K ++E +Q Q + + G +
Sbjct: 596 NWINKKKKLADDEDY-KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYA 654
Query: 1453 TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTD 1512
+D V ++ V + + ELLE ++ L + + QF + ED W+ + TS D
Sbjct: 655 SDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSED 714
Query: 1513 HGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA-------IRQ 1565
+G L VQ ++K+ L+ + Q ++D I+TD ++ E IR
Sbjct: 715 YGKGLAEVQNRLRKHGLLESAVAARQDQVD--------ILTDLAAYFEEIGHPDSKDIRA 766
Query: 1566 RLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQ 1625
R L + L E R ++L + Q D + EAW+ E E S KD
Sbjct: 767 RQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLI 826
Query: 1626 SAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKD 1685
++ +L +H+++ + + + + ++++ +V + H +E ++ R +++ L+
Sbjct: 827 ASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRA 886
Query: 1686 LAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFAR 1745
A R+ L+ + Q ++ + E WI E+E + + G D E L ++ F
Sbjct: 887 RAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLL 946
Query: 1746 DTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASY 1805
D + G D++ L ++ AA + E + +++A
Sbjct: 947 DLNSFG----DSMKALRNQANACQQQQAAPV---------------EGVAGEQRVMA--- 984
Query: 1806 ELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQ------ 1859
+ D + P E+ + V TL ++A Q
Sbjct: 985 ---------------LYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAV 1029
Query: 1860 -VRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFS 1918
VR+L D + ++ +I +R+ ++ ++SLLD E RR RL+ ++F
Sbjct: 1030 YVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAY 1089
Query: 1919 MVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLL 1978
D++ W+ QEK + + VEL E+ + D F + + L
Sbjct: 1090 EAGDMLEWI---------QEKKAENTGVEL------DDVWELQKKFDEFQKDLNTNEPRL 1134
Query: 1979 ARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILE-----------VHQFSRDAS 2027
+ ++++ + L LT + ++ + RW L+ + + V F R+A
Sbjct: 1135 RDINKVADDLLFEGL-LTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREAD 1193
Query: 2028 VAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL----ERLT--- 2080
+ + + LS+ + G + V+ L +RHE FE+ ++ + L ERL+
Sbjct: 1194 DTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESH 1253
Query: 2081 ----------TLELLEVRR--QQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVS 2128
+EL E Q ++RK + +A Q W +S G VS
Sbjct: 1254 PDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVS 1313
Query: 2129 QNGL 2132
L
Sbjct: 1314 SQEL 1317
Score = 247 bits (631), Expect = 9e-65
Identities = 282/1354 (20%), Positives = 559/1354 (41%), Gaps = 87/1354 (6%)
Query: 308 ESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLF 367
E A LL+ E ++ LN+ F +S+ ++ Q A + E+ + + F
Sbjct: 931 EEAAGALLKKHEAFLLDLNS--FGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDF 988
Query: 368 TIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHE--------RELA---------- 409
+S +K + L+S INK W ++E A+H+ R LA
Sbjct: 989 QARSPREVTMKKGDVLT---LLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQR 1045
Query: 410 ----LRNELIRQEKLEQLARRFDRKAAMRETWLSE--NQRLVS--------------QDN 449
N RQE++E R +A R L + N+ L++ +N
Sbjct: 1046 RREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAEN 1105
Query: 450 FGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRL 509
G +L V KK + + D+ E R++ + VA +L E + R++ R
Sbjct: 1106 TGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSR- 1164
Query: 510 WEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQK 569
W L L +RQ L ++ +E + +++ + + D G L V+ L ++
Sbjct: 1165 WGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRR 1224
Query: 570 HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAE 629
H E D+ ++V + +A++ + E + + R ++ + +++L +
Sbjct: 1225 HEGFERDLVPLGDKVTILGETAERLS---ESHPDATEDLQRQKM-ELNEAWEDLQGRTKD 1280
Query: 630 RRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSG 689
R+ L E+++ + F + + + WI ++SS + +DLT + LL +H+ +M
Sbjct: 1281 RKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEA 1340
Query: 690 RSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQF 749
+ F+ ++I H S +I +++ ++ + +LE+ RKK L++ L F
Sbjct: 1341 EAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMF 1400
Query: 750 QADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEI-ANYRPTLDTLHEQAS 808
Q + D +++WM+ + S D + S ++L+KK D+ + I A D H S
Sbjct: 1401 QGNCDQVESWMVARENSLRSDDKSSLD-SLEALMKKRDDLDKAITAQEGKITDLEHFAES 1459
Query: 809 ALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEK 868
+ EH ++ RL + +R+K + + L D L + + + + E WI E
Sbjct: 1460 LIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISE- 1518
Query: 869 EQWLNNMQIPEKLEDLEVIQHRF---ESLEPEMNNQASRVAVVNQIARQLMHSG--HPSE 923
+ E +D IQ ++ ++ E++ ++ +V V + L+ +E
Sbjct: 1519 ---MLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNE 1575
Query: 924 KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD 983
+ +K Q ++L W E + K L A Q ++ + + W+ E + + + +D
Sbjct: 1576 EAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSE-AETLLAMKD 1634
Query: 984 LGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV 1043
DLA L +K +ER+++A E L DL AE L S I+ + ++
Sbjct: 1635 QARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKR 1694
Query: 1044 WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQ 1103
+ ++ L EA L QF +DLDD +SW+ ++S+D L + LL +
Sbjct: 1695 FLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKK 1754
Query: 1104 HENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQN 1163
H+ ++ E+ +E Q + DM E + Q ++ RL W +L ++ + R
Sbjct: 1755 HKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEE-IQLRLAQFVEHWEKLKELAKARGL 1813
Query: 1164 LLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEE 1223
L +S Y QF+++ ++ EA++N + + + TL ++ + K E +E
Sbjct: 1814 KLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHET 1873
Query: 1224 KINAVVETGRRL---VSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKF 1280
++ V G + V + I K+++++++ + + ++L+D+ Q+F
Sbjct: 1874 RVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEF 1933
Query: 1281 LQDCQELSLWINEKMLTAQ-DMSYDEARNLHSKWLKHQAFMAELAS-NKEWLDKIEKEGM 1338
+ WI +K + + + + + + + K A L S +E L +I
Sbjct: 1934 NWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKD 1993
Query: 1339 QLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFD----ANKAE----LFTQSCA 1390
+LIS + ++E+ L K WE L + Q+L + KAE F +
Sbjct: 1994 KLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKAS 2053
Query: 1391 DLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEG 1450
L+ W +E + + L + L K + + + + + L Q + G
Sbjct: 2054 ALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALG 2113
Query: 1451 KSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQ---------FNRDVEDEILWV 1501
+ + V + + L + E + L +E Q F ++ + W+
Sbjct: 2114 VPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI 2173
Query: 1502 GERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE 1561
E T++ ++ N+ QKEIQ + ++ I + N+ D+ L
Sbjct: 2174 LETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL-EDALILD-- 2230
Query: 1562 AIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQ 1595
I+ L Q W L + + LE+ +A+
Sbjct: 2231 -IKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAK 2263
Score = 42.0 bits (97), Expect = 0.007
Identities = 30/142 (21%), Positives = 63/142 (44%), Gaps = 3/142 (2%)
Query: 392 INKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFG 451
+ + W+ L ERE L+ E RQ K ++ + F++ A+ W+ E + +
Sbjct: 2127 LERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLL 2186
Query: 452 FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWE 511
+ +E+ + ++ + +I A + ++ +V + LE DIK T + + W+
Sbjct: 2187 KETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTI---GLAQQWD 2243
Query: 512 YLLELLRARRQRLEMNLGLQKI 533
L +L + LE + + I
Sbjct: 2244 QLYQLGLRMQHNLEQQIQAKDI 2265
>gi|12025678 actinin, alpha 4 [Homo sapiens]
Length = 911
Score = 449 bits (1156), Expect = e-125
Identities = 272/721 (37%), Positives = 412/721 (57%), Gaps = 63/721 (8%)
Query: 28 DDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRM 87
DDWD + +E+ Q+KTFT W NSHL + +I ++ D RDG
Sbjct: 36 DDWDRDLLLDPAWEKQ------------QRKTFTAWCNSHLRKAGTQIENIDEDFRDGLK 83
Query: 88 LIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTL 147
L+ LLEV+SGERLPKP +G+MR+H + NV+KAL F+ + V L ++G+ +IVDGN ++TL
Sbjct: 84 LMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTL 143
Query: 148 GLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMA 207
G+IWTIILRF IQDISVE + SAK+ LLLWCQ KTA Y NVN+ NF SW+DG+A
Sbjct: 144 GMIWTIILRFAIQDISVE------ETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLA 197
Query: 208 FNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDI-SVDHPDEKSI 266
FNALIH+HRP+LI++DKL+K + NL NAF +AE++L + K+LD EDI + PDEK+I
Sbjct: 198 FNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAI 257
Query: 267 ITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILN 326
+TYV ++YH FS + RI KVL E E ++E YE LASDLLEWI +TI L
Sbjct: 258 MTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLE 317
Query: 327 NRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREG 386
+R ++ +QQ+L+ F YR V KPPK EK LE+ T+Q+K+R +N+ +MP EG
Sbjct: 318 DRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEG 377
Query: 387 KLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVS 446
K++SDIN W+ LE+AE E L NE+ R E+L+ LA +F +KA++ E W + ++
Sbjct: 378 KMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK 437
Query: 447 -QDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDN 505
+D L ++A +KHEA E+D+AA+++RV+ + A+A+EL +Y+D + R
Sbjct: 438 HRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQK 497
Query: 506 VIRLWEYLLELLRARRQRLE-MNLGLQKIFQEMLY-------IMDWMDEMKVLVLSQDYG 557
+ W+ L L +RR+ LE L+ I Q L +WM+ +
Sbjct: 498 ICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIV 557
Query: 558 KHLLGVEDLLQKH-----TLVEADIGIQAERVRGVNASAQKFA-------TDGEGYKPCD 605
+ +E L+ H TL +AD + E + ++ AQ+ A + Y
Sbjct: 558 HTIEEIEGLISAHDQFKSTLPDAD--REREAILAIHKEAQRIAESNHIKLSGSNPYTTVT 615
Query: 606 PQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEG-WIREKEKILSSD 664
PQ+I + ++ + E +++ + + L + F A G WI+ K
Sbjct: 616 PQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTK------- 668
Query: 665 DYGKDLTSVMRL-LSKHRAFEDEMSGRSGHFEQAI---KEGEDMIAEEHFGSEKIRERII 720
+ + R+ + + ED++S +E++I K D++ ++H + I+E +I
Sbjct: 669 -----MEEIGRISIEMNGTLEDQLS-HLKQYERSIVDYKPNLDLLEQQH---QLIQEALI 719
Query: 721 Y 721
+
Sbjct: 720 F 720
Score = 66.6 bits (161), Expect = 3e-10
Identities = 82/378 (21%), Positives = 166/378 (43%), Gaps = 65/378 (17%)
Query: 722 IREQWANLEQ---------LSAIRK-KRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 771
I W +LEQ L+ IR+ +RL+ L +F+ A +AW +
Sbjct: 383 INNGWQHLEQAEKGYEEWLLNEIRRLERLDH--LAEKFRQKASIHEAWTDG-----KEAM 435
Query: 772 VGHDEYST------QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRL 824
+ H +Y T ++L++KH+ ++A ++ ++ + A L + ++ +S +V R
Sbjct: 436 LKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRC 495
Query: 825 SGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACEL-----------WIDEKEQWLN 873
I +++ + LT R++AL+ T K D L W++ + L
Sbjct: 496 QKICDQWDALGSLTHSRREALEKT---EKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQ 552
Query: 874 NMQIPEKLEDLEVI---QHRFESLEPEMNNQASRVAVVNQIARQLMHSGH----PSEKEI 926
+M I +E++E + +F+S P+ + + + +++ A+++ S H S
Sbjct: 553 DMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYT 612
Query: 927 KAQQDKLNTRWSQFRELVDRKKDALLSALSIQ--NYHL------ECNETKSWIREKTK-- 976
+N++W + ++LV ++ ALL S Q N HL + N WI+ K +
Sbjct: 613 TVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEI 672
Query: 977 ---VIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAI 1033
IE L + L+ + +R + + +L +E + L +EA +++H +
Sbjct: 673 GRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQ-HQLIQEALIFDNKHTNYT--- 728
Query: 1034 LSRLAEISDVWEEMKTTL 1051
+ I WE++ TT+
Sbjct: 729 ---MEHIRVGWEQLLTTI 743
Score = 60.8 bits (146), Expect = 1e-08
Identities = 67/277 (24%), Positives = 114/277 (41%), Gaps = 38/277 (13%)
Query: 633 RLEESRRLWKFFWEMAE-EEGWIREKEKILSSDDYGK-DLTSVMRLLSKHRAFEDEMSGR 690
RLE L + F + A E W KE +L DY L+ + L+ KH AFE +++
Sbjct: 407 RLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAH 466
Query: 691 SGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRK-------KRLEEA 743
EQ +++ +++ S + R I +QW L L+ R+ K+LE
Sbjct: 467 QDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAI 526
Query: 744 SLLH-QFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH---KDVAEEIANYRPT 799
LH ++ A + WM ++ + + H + L+ H K + R
Sbjct: 527 DQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREA 586
Query: 800 LDTLHEQASALPQEHAESPDVRGRLSG-----------IEERYKEVAELTRLRKQAL--- 845
+ +H++A Q AES + +LSG I ++++V +L R AL
Sbjct: 587 ILAIHKEA----QRIAESNHI--KLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEE 640
Query: 846 ----QDTLALYKMF-SEADACELWIDEKEQWLNNMQI 877
Q L + F S+A+ WI K + + + I
Sbjct: 641 QSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISI 677
Score = 44.7 bits (104), Expect = 0.001
Identities = 43/193 (22%), Positives = 84/193 (43%), Gaps = 26/193 (13%)
Query: 1901 ESRRVRLVD-TGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRD-----VSSVELLMNNHQ 1954
E RR+ +D +KFR + + + W + EA K RD +S ++ L+ H+
Sbjct: 404 EIRRLERLDHLAEKFRQKASIHEA--WTDGK----EAMLKHRDYETATLSDIKALIRKHE 457
Query: 1955 GIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEK----------LLQLTEKRKEMID 2004
++++ A D + + L +Y S + + L LT R+E ++
Sbjct: 458 AFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALE 517
Query: 2005 KWEDRWEWLRLILEVH-QFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFE 2063
K E + L I ++H ++++ A+ W+ L I +++E+E LI H+ F+
Sbjct: 518 KTEKQ---LEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFK 574
Query: 2064 KSAATWDERFSAL 2076
+ D A+
Sbjct: 575 STLPDADREREAI 587
Score = 41.6 bits (96), Expect = 0.009
Identities = 38/163 (23%), Positives = 71/163 (43%), Gaps = 12/163 (7%)
Query: 1920 VRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLA 1979
+R + W+ED + Q QE + + H+ K + + + ++ L
Sbjct: 309 IRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSN 368
Query: 1980 RKHYASEEIKEKLLQLTEKRKEMIDKWEDRWE-WL--------RLILEVHQFSRDASVAE 2030
R + E K++ + +++ E +E WL RL +F + AS+ E
Sbjct: 369 RPAFMPSE--GKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE 426
Query: 2031 AWLLGQEPYLSSREIGQS-VDEVEKLIKRHEAFEKSAATWDER 2072
AW G+E L R+ + + +++ LI++HEAFE A +R
Sbjct: 427 AWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDR 469
Score = 39.7 bits (91), Expect = 0.035
Identities = 138/756 (18%), Positives = 279/756 (36%), Gaps = 148/756 (19%)
Query: 1139 FLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMP 1198
F Q + +T E +W R+ ++ Q F K AF L H P
Sbjct: 153 FAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAF-----NALIHRHRP 207
Query: 1199 TTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEK-----VDSI 1253
+E + +++D +T ++ E ++ + L ++ +N+ R EK V S
Sbjct: 208 ELIEYDKL---RKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSF 264
Query: 1254 DDRH---RKNRETASELLMRLKDNRDLQKFLQDCQELSL-----------WINEKM--LT 1297
+K A+ + L N++ + ++D ++L+ W+ +++ T
Sbjct: 265 YHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKT 324
Query: 1298 AQDMS-----YDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVK 1352
Q+M + + R +H + E+ N + +S +P
Sbjct: 325 IQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNT-------LQTKLRLSNRPAFMPSEG 377
Query: 1353 EKLTGLHKMWEVLESTTQTKAQRLFDANK--------AELFTQSCADLDKWLHGLESQIQ 1404
+ ++ ++ W+ LE + + L + + AE F Q + + W G E+ ++
Sbjct: 378 KMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK 437
Query: 1405 SDDY-GKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTV 1463
DY L+ + L++K + E+ + + +E Q A++QE D DS +
Sbjct: 438 HRDYETATLSDIKALIRKHEAFESDLAAHQDRVE----QIAAIAQELNELDYYDSHNVNT 493
Query: 1464 Q-TKFMELLEPLNERKHNLLASKEIHQFNRDVEDEI------------LWVGERMPLATS 1510
+ K + + L H+ + E + + D++ W+ M
Sbjct: 494 RCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQD 553
Query: 1511 TDHGHNLQTVQLLIKKNQTLQK---EIQGHQPRIDDIFERSQNIVTDS----------SS 1557
H ++ ++ LI + + + + I I + +Q I + ++
Sbjct: 554 MFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTT 613
Query: 1558 LSAEAIRQRLADLKQLW----GLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE--Q 1611
++ + I + ++QL L+EE K+ H +Q+ A W+ +
Sbjct: 614 VTPQIINSKWEKVQQLVPKRDHALLEEQSKQQ---SNEHLRRQFASQANVVGPWIQTKME 670
Query: 1612 ELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDY------AETVHQLSKTSRALVADSHPE 1665
E+ +S E + +S LK++ E+++ DY E HQL AL+ D+ +
Sbjct: 671 EIGRISIEMNGTLEDQLSHLKQY---ERSIVDYKPNLDLLEQQHQL--IQEALIFDN--K 723
Query: 1666 SERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHE 1725
+M +V G + L L + R ++++E I R+ S E
Sbjct: 724 HTNYTMEHIRV-----GWEQL-------------LTTIARTINEVENQILTRDAKGISQE 765
Query: 1726 LGQDYEHVTMLQERFREFARDTGN-IGQER---------VDTVNHLADE--------LIN 1767
Q++ + F F +D G +G E D N E L++
Sbjct: 766 QMQEF------RASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVD 819
Query: 1768 SGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAA 1803
HS T + D ++ D DT Q++A+
Sbjct: 820 PNHSGLVTFQAFIDFMSRETTD----TDTADQVIAS 851
Score = 38.1 bits (87), Expect = 0.10
Identities = 63/322 (19%), Positives = 115/322 (35%), Gaps = 54/322 (16%)
Query: 1791 LELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFE 1850
LE +D + +H+ + D KE + +D + ++ L R H FE
Sbjct: 408 LERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSD-------IKALIRKHEAFE 460
Query: 1851 HDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDT 1910
D+ A +V Q+ A L D + ++ R ++ + W +L SRR L T
Sbjct: 461 SDLAAHQDRVEQIAAIAQELNELDYYD-SHNVNTRCQKICDQWDALGSLTHSRREALEKT 519
Query: 1911 GDK--------FRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDA 1962
+ + WME + ++ + +E L++ H K+ +
Sbjct: 520 EKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPD 579
Query: 1963 RNDSFTTCIELGKSLLARKHYASEEIK-------------------EKLLQLTEKRKEMI 2003
+ + + K A++ S IK EK+ QL KR +
Sbjct: 580 ADREREAILAIHKE--AQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHAL 637
Query: 2004 DKWEDRW---EWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDE----VEKLI 2056
+ + + E LR QF+ A+V W+ EIG+ E +E +
Sbjct: 638 LEEQSKQQSNEHLR-----RQFASQANVVGPWI-----QTKMEEIGRISIEMNGTLEDQL 687
Query: 2057 KRHEAFEKSAATWDERFSALER 2078
+ +E+S + LE+
Sbjct: 688 SHLKQYERSIVDYKPNLDLLEQ 709
>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
Length = 887
Score = 445 bits (1145), Expect = e-124
Identities = 273/696 (39%), Positives = 399/696 (57%), Gaps = 51/696 (7%)
Query: 53 EAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHC 112
E Q+KTFT W NSHL + +I ++ D RDG L+ LLEV+SGERL KP +G+MR+H
Sbjct: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
Query: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEK 172
+ NV+KAL F+ + V L ++G+ +IVDGN ++TLG+IWTIILRF IQDISVE +
Sbjct: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVE------E 143
Query: 173 KSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHY 232
SAK+ LLLWCQ KTA Y NVNI NF SW+DG+ F ALIH+HRP+LID+ KL+K +
Sbjct: 144 TSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
Query: 233 NLQNAFNLAEQHLGLTKLLDPEDI-SVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIG 291
NL AF++AE++L + K+LD EDI PDEK+I+TYV ++YH FS + RI
Sbjct: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
Query: 292 KVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVE 351
KVL E E+++E YE LASDLLEWI +TI L NR N++ +QQ+L+ F YR +
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
Query: 352 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 411
KPPK EK LE+ T+Q+K+R +N+ +MP EG+++SDIN AW LE+ E E L
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNF-GFDLPAVEAATKKHEAIETD 470
NE+ R E+L+ LA +F +KA++ E W + ++ Q ++ L ++A KKHEA E+D
Sbjct: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
Query: 471 IAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGL 530
+AA+++RV+ + A+A+EL +Y+D + AR + W+ L L + RR+ LE L
Sbjct: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Query: 531 QKIFQEMLY--------IMDWMDEMKVLVLSQDYGKHLL-GVEDLLQKH-----TLVEAD 576
+ ++ +WM E + L + H + ++ L H TL +AD
Sbjct: 504 LETIDQLYLEYAKRAAPFNNWM-EGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562
Query: 577 ------IGIQAERVRGVNASAQKFATDGEG---YKPCDPQVIRDRVAHMEFCYQELCQLA 627
+GI E V+ Q + + G Y PQ I + H+ Q
Sbjct: 563 KERLAILGIHNE----VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQAL 618
Query: 628 AERRARLEESRRLWKFFWEMAEEEG-WIREKEKILSSDDYGKDLTSVMRL-LSKHRAFED 685
E AR + + RL K F A G WI+ K + + R+ + H ED
Sbjct: 619 TEEHARQQHNERLRKQFGAQANVIGPWIQTK------------MEEIGRISIEMHGTLED 666
Query: 686 EMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIY 721
++S +E++I + I + + I+E +I+
Sbjct: 667 QLS-HLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF 701
Score = 61.6 bits (148), Expect = 9e-09
Identities = 64/271 (23%), Positives = 108/271 (39%), Gaps = 26/271 (9%)
Query: 633 RLEESRRLWKFFWEMAE-EEGWIREKEKILSSDDYGK-DLTSVMRLLSKHRAFEDEMSGR 690
RLE L + F + A E W KE +L DY L+ + LL KH AFE +++
Sbjct: 388 RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
Query: 691 SGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA------- 743
EQ +++ +++ S + R I +QW NL L+ R++ LE
Sbjct: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI 507
Query: 744 -SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH---KDVAEEIANYRPT 799
L ++ A + WM ++ + + + H Q L H K + R
Sbjct: 508 DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA 567
Query: 800 LDTLHEQASALPQEH-----AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA---- 850
+ +H + S + Q + +P I ++ V +L R QAL + A
Sbjct: 568 ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQH 627
Query: 851 ---LYKMF-SEADACELWIDEKEQWLNNMQI 877
L K F ++A+ WI K + + + I
Sbjct: 628 NERLRKQFGAQANVIGPWIQTKMEEIGRISI 658
Score = 57.4 bits (137), Expect = 2e-07
Identities = 83/424 (19%), Positives = 161/424 (37%), Gaps = 45/424 (10%)
Query: 788 DVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRK----- 842
DVAE+ + LD +A P E A V K R+ K
Sbjct: 210 DVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVN 269
Query: 843 QALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE--------KLEDLEVIQHRFESL 894
Q + + Y+ + +D E WI WL N ++PE KLED +R
Sbjct: 270 QENEQLMEDYEKLA-SDLLE-WIRRTIPWLEN-RVPENTMHAMQQKLEDFR--DYRRLHK 324
Query: 895 EPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ-DKLNTRWSQFRELVDRKKDALLS 953
P++ + N + +L S P+ + + +N W ++ ++ LL+
Sbjct: 325 PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLN 384
Query: 954 ALS--------IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDL 1005
+ + + + + ++W K ++ L+ + AL +K E DL
Sbjct: 385 EIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDL 444
Query: 1006 VAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQ 1065
A + ++ + A++L + ++ +R +I D W+ + + R +L KL
Sbjct: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLL 504
Query: 1066 QFLRDL--------DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEED 1117
+ + L F +W+ + + +T+ E + L T HE K + + D
Sbjct: 505 ETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLP--DAD 562
Query: 1118 YQKMRDMG---EMVTQGQTDAQYM-----FLRQRLQALDTGWNELHKMWENRQNLLSQSH 1169
+++ +G E+ QT M + Q ++ W+ + ++ R L++ H
Sbjct: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
Query: 1170 AYQQ 1173
A QQ
Sbjct: 623 ARQQ 626
Score = 55.5 bits (132), Expect = 6e-07
Identities = 76/366 (20%), Positives = 149/366 (40%), Gaps = 40/366 (10%)
Query: 1567 LADLKQLWGLLIEETEKRH--------RRLEEA-HRAQQYYFDAAEAEAWMSEQELYMMS 1617
++D+ WG L E+ EK + RRLE H A+++ A+ EAW +E +
Sbjct: 361 VSDINNAWGCL-EQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ 419
Query: 1618 EEKAKDEQSAV-SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKV 1676
++ S + ++LKKH+ E + + + V Q++ ++ L + +S ++ R K+
Sbjct: 420 KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI 479
Query: 1677 DKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREV-----VAGSHELGQD-- 1729
+ L L ++RR L+ +L + +D L A+R + G+ E QD
Sbjct: 480 CDQWDNLGALTQKRREALERTEKLLE---TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTF 536
Query: 1730 ----YEHVTMLQERFREFARDTGNIGQERVDT--VNHLADELINSGHSDAATIAEW---- 1779
E + L +F + +ER+ +++ +++ + H + A +
Sbjct: 537 IVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTIT 596
Query: 1780 KDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGR--------IQDKHKKLPEE 1831
+N W + +L+ R Q L + + ++ FG IQ K +++
Sbjct: 597 PQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRI 656
Query: 1832 LGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLE 1891
T+E +E I ++ QL+ D +Q A D E+ +
Sbjct: 657 SIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEH-IRV 715
Query: 1892 AWKSLL 1897
W+ LL
Sbjct: 716 GWEQLL 721
Score = 55.1 bits (131), Expect = 8e-07
Identities = 70/366 (19%), Positives = 156/366 (42%), Gaps = 41/366 (11%)
Query: 722 IREQWANLEQ---------LSAIRK-KRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 771
I W LEQ L+ IR+ +RL+ L +F+ A +AW ++ D
Sbjct: 364 INNAWGCLEQVEKGYEEWLLNEIRRLERLDH--LAEKFRQKASIHEAWTDGKEAMLRQKD 421
Query: 772 VGHDEYST-QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRLSGIEE 829
S ++L+KKH+ ++A ++ ++ + A L + ++ +SP V R I +
Sbjct: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
Query: 830 RYKEVAELTRLRKQALQDTLALYKMFSE--------ADACELWIDEKEQWLNNMQIPEKL 881
++ + LT+ R++AL+ T L + + A W++ + L + I +
Sbjct: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541
Query: 882 EDLEVI---QHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS----EKEIKAQQDKLN 934
E+++ + +F++ P+ + + + ++ +++ + H + ++N
Sbjct: 542 EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
Query: 935 TRWSQFRELVDRKKDALLSALSIQNYH--------LECNETKSWIREKTKVIESTQDLGN 986
+W R+LV R+ AL + Q ++ + N WI+ K +E +
Sbjct: 602 GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTK---MEEIGRISI 658
Query: 987 DLAGVMALQ-RKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWE 1045
++ G + Q L E+ +V + K+ L+ + + ++ + + I WE
Sbjct: 659 EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE 718
Query: 1046 EMKTTL 1051
++ TT+
Sbjct: 719 QLLTTI 724
Score = 43.1 bits (100), Expect = 0.003
Identities = 41/189 (21%), Positives = 86/189 (45%), Gaps = 18/189 (9%)
Query: 1901 ESRRVRLVD-TGDKFRFFSMVRDLML-WMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKA 1958
E RR+ +D +KFR + + + E ++RQ + + +S ++ L+ H+ ++
Sbjct: 385 EIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442
Query: 1959 EIDARNDSFTTCIELGKSLLARKHYASEEIK----------EKLLQLTEKRKEMIDKWED 2008
++ A D + + L +Y S + + L LT+KR+E +++ E
Sbjct: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
Query: 2009 RWEWL-RLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAA 2067
E + +L LE +++ A+ W+ G L I +++E++ L HE F+ +
Sbjct: 503 LLETIDQLYLE---YAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLP 559
Query: 2068 TWDERFSAL 2076
D+ A+
Sbjct: 560 DADKERLAI 568
Score = 40.4 bits (93), Expect = 0.021
Identities = 35/153 (22%), Positives = 66/153 (43%), Gaps = 23/153 (15%)
Query: 2001 EMIDKWEDRW------EWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQS-VDEVE 2053
E ++K + W RL +F + AS+ EAW G+E L ++ + + E++
Sbjct: 372 EQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIK 431
Query: 2054 KLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEA 2113
L+K+HEAFE A +R ++ + ++ E + P K+ +
Sbjct: 432 ALLKKHEAFESDLAAHQDRVE--------QIAAIAQELNELDYYDSPSVNARCQKICD-- 481
Query: 2114 ESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD 2146
QWD ++Q A + + ++ ET+D
Sbjct: 482 ----QWDNLGA--LTQKRREALERTEKLLETID 508
Score = 38.5 bits (88), Expect = 0.079
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 1382 AELFTQSCADLDKWLHGLESQIQSDDYGK-DLTSVNILLKKQQMLENQMEVRKKEIEELQ 1440
AE F Q + + W G E+ ++ DY L+ + LLKK + E+ + + +E++
Sbjct: 396 AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIA 455
Query: 1441 SQAQALSQ 1448
+ AQ L++
Sbjct: 456 AIAQELNE 463
Score = 36.6 bits (83), Expect = 0.30
Identities = 33/157 (21%), Positives = 65/157 (41%), Gaps = 9/157 (5%)
Query: 1517 LQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL 1576
L ++ L+KK++ + ++ HQ R++ I +Q + + + ++ R + W
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQEL-NELDYYDSPSVNARCQKICDQWDN 485
Query: 1577 LIEETEKRHRRLEEAHR----AQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLK 1632
L T+KR LE + Q Y + A+ A + +M + + V ++
Sbjct: 486 LGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNN---WMEGAMEDLQDTFIVHTIE 542
Query: 1633 KHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669
+ Q L A E + T+ K R + H E +I
Sbjct: 543 EIQGLTTAHEQFKATLPDADK-ERLAILGIHNEVSKI 578
Score = 33.1 bits (74), Expect = 3.3
Identities = 29/137 (21%), Positives = 56/137 (40%), Gaps = 10/137 (7%)
Query: 1278 QKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWL--KHQAFMAELASNKEWLDKIEK 1335
+KF Q W + K + Y+ A K L KH+AF ++LA++++ +++I
Sbjct: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
Query: 1336 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-----EL---FTQ 1387
+L V + + W+ L + TQ + + L K +L + +
Sbjct: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
Query: 1388 SCADLDKWLHGLESQIQ 1404
A + W+ G +Q
Sbjct: 517 RAAPFNNWMEGAMEDLQ 533
>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
Length = 914
Score = 445 bits (1145), Expect = e-124
Identities = 273/696 (39%), Positives = 399/696 (57%), Gaps = 51/696 (7%)
Query: 53 EAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHC 112
E Q+KTFT W NSHL + +I ++ D RDG L+ LLEV+SGERL KP +G+MR+H
Sbjct: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
Query: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEK 172
+ NV+KAL F+ + V L ++G+ +IVDGN ++TLG+IWTIILRF IQDISVE +
Sbjct: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVE------E 143
Query: 173 KSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHY 232
SAK+ LLLWCQ KTA Y NVNI NF SW+DG+ F ALIH+HRP+LID+ KL+K +
Sbjct: 144 TSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
Query: 233 NLQNAFNLAEQHLGLTKLLDPEDI-SVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIG 291
NL AF++AE++L + K+LD EDI PDEK+I+TYV ++YH FS + RI
Sbjct: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
Query: 292 KVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVE 351
KVL E E+++E YE LASDLLEWI +TI L NR N++ +QQ+L+ F YR +
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
Query: 352 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 411
KPPK EK LE+ T+Q+K+R +N+ +MP EG+++SDIN AW LE+ E E L
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNF-GFDLPAVEAATKKHEAIETD 470
NE+ R E+L+ LA +F +KA++ E W + ++ Q ++ L ++A KKHEA E+D
Sbjct: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
Query: 471 IAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGL 530
+AA+++RV+ + A+A+EL +Y+D + AR + W+ L L + RR+ LE L
Sbjct: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Query: 531 QKIFQEMLY--------IMDWMDEMKVLVLSQDYGKHLL-GVEDLLQKH-----TLVEAD 576
+ ++ +WM E + L + H + ++ L H TL +AD
Sbjct: 504 LETIDQLYLEYAKRAAPFNNWM-EGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562
Query: 577 ------IGIQAERVRGVNASAQKFATDGEG---YKPCDPQVIRDRVAHMEFCYQELCQLA 627
+GI E V+ Q + + G Y PQ I + H+ Q
Sbjct: 563 KERLAILGIHNE----VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQAL 618
Query: 628 AERRARLEESRRLWKFFWEMAEEEG-WIREKEKILSSDDYGKDLTSVMRL-LSKHRAFED 685
E AR + + RL K F A G WI+ K + + R+ + H ED
Sbjct: 619 TEEHARQQHNERLRKQFGAQANVIGPWIQTK------------MEEIGRISIEMHGTLED 666
Query: 686 EMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIY 721
++S +E++I + I + + I+E +I+
Sbjct: 667 QLS-HLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF 701
Score = 61.6 bits (148), Expect = 9e-09
Identities = 64/271 (23%), Positives = 108/271 (39%), Gaps = 26/271 (9%)
Query: 633 RLEESRRLWKFFWEMAE-EEGWIREKEKILSSDDYGK-DLTSVMRLLSKHRAFEDEMSGR 690
RLE L + F + A E W KE +L DY L+ + LL KH AFE +++
Sbjct: 388 RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
Query: 691 SGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA------- 743
EQ +++ +++ S + R I +QW NL L+ R++ LE
Sbjct: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI 507
Query: 744 -SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH---KDVAEEIANYRPT 799
L ++ A + WM ++ + + + H Q L H K + R
Sbjct: 508 DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA 567
Query: 800 LDTLHEQASALPQEH-----AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA---- 850
+ +H + S + Q + +P I ++ V +L R QAL + A
Sbjct: 568 ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQH 627
Query: 851 ---LYKMF-SEADACELWIDEKEQWLNNMQI 877
L K F ++A+ WI K + + + I
Sbjct: 628 NERLRKQFGAQANVIGPWIQTKMEEIGRISI 658
Score = 57.4 bits (137), Expect = 2e-07
Identities = 83/424 (19%), Positives = 161/424 (37%), Gaps = 45/424 (10%)
Query: 788 DVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRK----- 842
DVAE+ + LD +A P E A V K R+ K
Sbjct: 210 DVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVN 269
Query: 843 QALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE--------KLEDLEVIQHRFESL 894
Q + + Y+ + +D E WI WL N ++PE KLED +R
Sbjct: 270 QENEQLMEDYEKLA-SDLLE-WIRRTIPWLEN-RVPENTMHAMQQKLEDFR--DYRRLHK 324
Query: 895 EPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ-DKLNTRWSQFRELVDRKKDALLS 953
P++ + N + +L S P+ + + +N W ++ ++ LL+
Sbjct: 325 PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLN 384
Query: 954 ALS--------IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDL 1005
+ + + + + ++W K ++ L+ + AL +K E DL
Sbjct: 385 EIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDL 444
Query: 1006 VAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQ 1065
A + ++ + A++L + ++ +R +I D W+ + + R +L KL
Sbjct: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLL 504
Query: 1066 QFLRDL--------DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEED 1117
+ + L F +W+ + + +T+ E + L T HE K + + D
Sbjct: 505 ETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLP--DAD 562
Query: 1118 YQKMRDMG---EMVTQGQTDAQYM-----FLRQRLQALDTGWNELHKMWENRQNLLSQSH 1169
+++ +G E+ QT M + Q ++ W+ + ++ R L++ H
Sbjct: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
Query: 1170 AYQQ 1173
A QQ
Sbjct: 623 ARQQ 626
Score = 55.5 bits (132), Expect = 6e-07
Identities = 76/366 (20%), Positives = 149/366 (40%), Gaps = 40/366 (10%)
Query: 1567 LADLKQLWGLLIEETEKRH--------RRLEEA-HRAQQYYFDAAEAEAWMSEQELYMMS 1617
++D+ WG L E+ EK + RRLE H A+++ A+ EAW +E +
Sbjct: 361 VSDINNAWGCL-EQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ 419
Query: 1618 EEKAKDEQSAV-SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKV 1676
++ S + ++LKKH+ E + + + V Q++ ++ L + +S ++ R K+
Sbjct: 420 KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI 479
Query: 1677 DKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREV-----VAGSHELGQD-- 1729
+ L L ++RR L+ +L + +D L A+R + G+ E QD
Sbjct: 480 CDQWDNLGALTQKRREALERTEKLLE---TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTF 536
Query: 1730 ----YEHVTMLQERFREFARDTGNIGQERVDT--VNHLADELINSGHSDAATIAEW---- 1779
E + L +F + +ER+ +++ +++ + H + A +
Sbjct: 537 IVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTIT 596
Query: 1780 KDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGR--------IQDKHKKLPEE 1831
+N W + +L+ R Q L + + ++ FG IQ K +++
Sbjct: 597 PQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRI 656
Query: 1832 LGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLE 1891
T+E +E I ++ QL+ D +Q A D E+ +
Sbjct: 657 SIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEH-IRV 715
Query: 1892 AWKSLL 1897
W+ LL
Sbjct: 716 GWEQLL 721
Score = 55.1 bits (131), Expect = 8e-07
Identities = 70/366 (19%), Positives = 156/366 (42%), Gaps = 41/366 (11%)
Query: 722 IREQWANLEQ---------LSAIRK-KRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 771
I W LEQ L+ IR+ +RL+ L +F+ A +AW ++ D
Sbjct: 364 INNAWGCLEQVEKGYEEWLLNEIRRLERLDH--LAEKFRQKASIHEAWTDGKEAMLRQKD 421
Query: 772 VGHDEYST-QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRLSGIEE 829
S ++L+KKH+ ++A ++ ++ + A L + ++ +SP V R I +
Sbjct: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
Query: 830 RYKEVAELTRLRKQALQDTLALYKMFSE--------ADACELWIDEKEQWLNNMQIPEKL 881
++ + LT+ R++AL+ T L + + A W++ + L + I +
Sbjct: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541
Query: 882 EDLEVI---QHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS----EKEIKAQQDKLN 934
E+++ + +F++ P+ + + + ++ +++ + H + ++N
Sbjct: 542 EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
Query: 935 TRWSQFRELVDRKKDALLSALSIQNYH--------LECNETKSWIREKTKVIESTQDLGN 986
+W R+LV R+ AL + Q ++ + N WI+ K +E +
Sbjct: 602 GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTK---MEEIGRISI 658
Query: 987 DLAGVMALQ-RKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWE 1045
++ G + Q L E+ +V + K+ L+ + + ++ + + I WE
Sbjct: 659 EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE 718
Query: 1046 EMKTTL 1051
++ TT+
Sbjct: 719 QLLTTI 724
Score = 43.1 bits (100), Expect = 0.003
Identities = 41/189 (21%), Positives = 86/189 (45%), Gaps = 18/189 (9%)
Query: 1901 ESRRVRLVD-TGDKFRFFSMVRDLML-WMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKA 1958
E RR+ +D +KFR + + + E ++RQ + + +S ++ L+ H+ ++
Sbjct: 385 EIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442
Query: 1959 EIDARNDSFTTCIELGKSLLARKHYASEEIK----------EKLLQLTEKRKEMIDKWED 2008
++ A D + + L +Y S + + L LT+KR+E +++ E
Sbjct: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
Query: 2009 RWEWL-RLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAA 2067
E + +L LE +++ A+ W+ G L I +++E++ L HE F+ +
Sbjct: 503 LLETIDQLYLE---YAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLP 559
Query: 2068 TWDERFSAL 2076
D+ A+
Sbjct: 560 DADKERLAI 568
Score = 40.4 bits (93), Expect = 0.021
Identities = 35/153 (22%), Positives = 66/153 (43%), Gaps = 23/153 (15%)
Query: 2001 EMIDKWEDRW------EWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQS-VDEVE 2053
E ++K + W RL +F + AS+ EAW G+E L ++ + + E++
Sbjct: 372 EQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIK 431
Query: 2054 KLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEA 2113
L+K+HEAFE A +R ++ + ++ E + P K+ +
Sbjct: 432 ALLKKHEAFESDLAAHQDRVE--------QIAAIAQELNELDYYDSPSVNARCQKICD-- 481
Query: 2114 ESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD 2146
QWD ++Q A + + ++ ET+D
Sbjct: 482 ----QWDNLGA--LTQKRREALERTEKLLETID 508
Score = 38.5 bits (88), Expect = 0.079
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 1382 AELFTQSCADLDKWLHGLESQIQSDDYGK-DLTSVNILLKKQQMLENQMEVRKKEIEELQ 1440
AE F Q + + W G E+ ++ DY L+ + LLKK + E+ + + +E++
Sbjct: 396 AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIA 455
Query: 1441 SQAQALSQ 1448
+ AQ L++
Sbjct: 456 AIAQELNE 463
Score = 36.6 bits (83), Expect = 0.30
Identities = 33/157 (21%), Positives = 65/157 (41%), Gaps = 9/157 (5%)
Query: 1517 LQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL 1576
L ++ L+KK++ + ++ HQ R++ I +Q + + + ++ R + W
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQEL-NELDYYDSPSVNARCQKICDQWDN 485
Query: 1577 LIEETEKRHRRLEEAHR----AQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLK 1632
L T+KR LE + Q Y + A+ A + +M + + V ++
Sbjct: 486 LGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNN---WMEGAMEDLQDTFIVHTIE 542
Query: 1633 KHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669
+ Q L A E + T+ K R + H E +I
Sbjct: 543 EIQGLTTAHEQFKATLPDADK-ERLAILGIHNEVSKI 578
Score = 33.1 bits (74), Expect = 3.3
Identities = 29/137 (21%), Positives = 56/137 (40%), Gaps = 10/137 (7%)
Query: 1278 QKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWL--KHQAFMAELASNKEWLDKIEK 1335
+KF Q W + K + Y+ A K L KH+AF ++LA++++ +++I
Sbjct: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
Query: 1336 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-----EL---FTQ 1387
+L V + + W+ L + TQ + + L K +L + +
Sbjct: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
Query: 1388 SCADLDKWLHGLESQIQ 1404
A + W+ G +Q
Sbjct: 517 RAAPFNNWMEGAMEDLQ 533
>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
Length = 892
Score = 445 bits (1145), Expect = e-124
Identities = 273/696 (39%), Positives = 399/696 (57%), Gaps = 51/696 (7%)
Query: 53 EAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHC 112
E Q+KTFT W NSHL + +I ++ D RDG L+ LLEV+SGERL KP +G+MR+H
Sbjct: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
Query: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEK 172
+ NV+KAL F+ + V L ++G+ +IVDGN ++TLG+IWTIILRF IQDISVE +
Sbjct: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVE------E 143
Query: 173 KSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHY 232
SAK+ LLLWCQ KTA Y NVNI NF SW+DG+ F ALIH+HRP+LID+ KL+K +
Sbjct: 144 TSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
Query: 233 NLQNAFNLAEQHLGLTKLLDPEDI-SVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIG 291
NL AF++AE++L + K+LD EDI PDEK+I+TYV ++YH FS + RI
Sbjct: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
Query: 292 KVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVE 351
KVL E E+++E YE LASDLLEWI +TI L NR N++ +QQ+L+ F YR +
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
Query: 352 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 411
KPPK EK LE+ T+Q+K+R +N+ +MP EG+++SDIN AW LE+ E E L
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNF-GFDLPAVEAATKKHEAIETD 470
NE+ R E+L+ LA +F +KA++ E W + ++ Q ++ L ++A KKHEA E+D
Sbjct: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
Query: 471 IAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGL 530
+AA+++RV+ + A+A+EL +Y+D + AR + W+ L L + RR+ LE L
Sbjct: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Query: 531 QKIFQEMLY--------IMDWMDEMKVLVLSQDYGKHLL-GVEDLLQKH-----TLVEAD 576
+ ++ +WM E + L + H + ++ L H TL +AD
Sbjct: 504 LETIDQLYLEYAKRAAPFNNWM-EGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562
Query: 577 ------IGIQAERVRGVNASAQKFATDGEG---YKPCDPQVIRDRVAHMEFCYQELCQLA 627
+GI E V+ Q + + G Y PQ I + H+ Q
Sbjct: 563 KERLAILGIHNE----VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQAL 618
Query: 628 AERRARLEESRRLWKFFWEMAEEEG-WIREKEKILSSDDYGKDLTSVMRL-LSKHRAFED 685
E AR + + RL K F A G WI+ K + + R+ + H ED
Sbjct: 619 TEEHARQQHNERLRKQFGAQANVIGPWIQTK------------MEEIGRISIEMHGTLED 666
Query: 686 EMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIY 721
++S +E++I + I + + I+E +I+
Sbjct: 667 QLS-HLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF 701
Score = 61.6 bits (148), Expect = 9e-09
Identities = 64/271 (23%), Positives = 108/271 (39%), Gaps = 26/271 (9%)
Query: 633 RLEESRRLWKFFWEMAE-EEGWIREKEKILSSDDYGK-DLTSVMRLLSKHRAFEDEMSGR 690
RLE L + F + A E W KE +L DY L+ + LL KH AFE +++
Sbjct: 388 RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
Query: 691 SGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA------- 743
EQ +++ +++ S + R I +QW NL L+ R++ LE
Sbjct: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI 507
Query: 744 -SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH---KDVAEEIANYRPT 799
L ++ A + WM ++ + + + H Q L H K + R
Sbjct: 508 DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA 567
Query: 800 LDTLHEQASALPQEH-----AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA---- 850
+ +H + S + Q + +P I ++ V +L R QAL + A
Sbjct: 568 ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQH 627
Query: 851 ---LYKMF-SEADACELWIDEKEQWLNNMQI 877
L K F ++A+ WI K + + + I
Sbjct: 628 NERLRKQFGAQANVIGPWIQTKMEEIGRISI 658
Score = 57.4 bits (137), Expect = 2e-07
Identities = 83/424 (19%), Positives = 161/424 (37%), Gaps = 45/424 (10%)
Query: 788 DVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRK----- 842
DVAE+ + LD +A P E A V K R+ K
Sbjct: 210 DVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVN 269
Query: 843 QALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE--------KLEDLEVIQHRFESL 894
Q + + Y+ + +D E WI WL N ++PE KLED +R
Sbjct: 270 QENEQLMEDYEKLA-SDLLE-WIRRTIPWLEN-RVPENTMHAMQQKLEDFR--DYRRLHK 324
Query: 895 EPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ-DKLNTRWSQFRELVDRKKDALLS 953
P++ + N + +L S P+ + + +N W ++ ++ LL+
Sbjct: 325 PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLN 384
Query: 954 ALS--------IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDL 1005
+ + + + + ++W K ++ L+ + AL +K E DL
Sbjct: 385 EIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDL 444
Query: 1006 VAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQ 1065
A + ++ + A++L + ++ +R +I D W+ + + R +L KL
Sbjct: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLL 504
Query: 1066 QFLRDL--------DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEED 1117
+ + L F +W+ + + +T+ E + L T HE K + + D
Sbjct: 505 ETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLP--DAD 562
Query: 1118 YQKMRDMG---EMVTQGQTDAQYM-----FLRQRLQALDTGWNELHKMWENRQNLLSQSH 1169
+++ +G E+ QT M + Q ++ W+ + ++ R L++ H
Sbjct: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
Query: 1170 AYQQ 1173
A QQ
Sbjct: 623 ARQQ 626
Score = 55.5 bits (132), Expect = 6e-07
Identities = 76/366 (20%), Positives = 149/366 (40%), Gaps = 40/366 (10%)
Query: 1567 LADLKQLWGLLIEETEKRH--------RRLEEA-HRAQQYYFDAAEAEAWMSEQELYMMS 1617
++D+ WG L E+ EK + RRLE H A+++ A+ EAW +E +
Sbjct: 361 VSDINNAWGCL-EQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ 419
Query: 1618 EEKAKDEQSAV-SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKV 1676
++ S + ++LKKH+ E + + + V Q++ ++ L + +S ++ R K+
Sbjct: 420 KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI 479
Query: 1677 DKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREV-----VAGSHELGQD-- 1729
+ L L ++RR L+ +L + +D L A+R + G+ E QD
Sbjct: 480 CDQWDNLGALTQKRREALERTEKLLE---TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTF 536
Query: 1730 ----YEHVTMLQERFREFARDTGNIGQERVDT--VNHLADELINSGHSDAATIAEW---- 1779
E + L +F + +ER+ +++ +++ + H + A +
Sbjct: 537 IVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTIT 596
Query: 1780 KDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGR--------IQDKHKKLPEE 1831
+N W + +L+ R Q L + + ++ FG IQ K +++
Sbjct: 597 PQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRI 656
Query: 1832 LGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLE 1891
T+E +E I ++ QL+ D +Q A D E+ +
Sbjct: 657 SIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEH-IRV 715
Query: 1892 AWKSLL 1897
W+ LL
Sbjct: 716 GWEQLL 721
Score = 55.1 bits (131), Expect = 8e-07
Identities = 70/366 (19%), Positives = 156/366 (42%), Gaps = 41/366 (11%)
Query: 722 IREQWANLEQ---------LSAIRK-KRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 771
I W LEQ L+ IR+ +RL+ L +F+ A +AW ++ D
Sbjct: 364 INNAWGCLEQVEKGYEEWLLNEIRRLERLDH--LAEKFRQKASIHEAWTDGKEAMLRQKD 421
Query: 772 VGHDEYST-QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRLSGIEE 829
S ++L+KKH+ ++A ++ ++ + A L + ++ +SP V R I +
Sbjct: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
Query: 830 RYKEVAELTRLRKQALQDTLALYKMFSE--------ADACELWIDEKEQWLNNMQIPEKL 881
++ + LT+ R++AL+ T L + + A W++ + L + I +
Sbjct: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541
Query: 882 EDLEVI---QHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS----EKEIKAQQDKLN 934
E+++ + +F++ P+ + + + ++ +++ + H + ++N
Sbjct: 542 EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
Query: 935 TRWSQFRELVDRKKDALLSALSIQNYH--------LECNETKSWIREKTKVIESTQDLGN 986
+W R+LV R+ AL + Q ++ + N WI+ K +E +
Sbjct: 602 GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTK---MEEIGRISI 658
Query: 987 DLAGVMALQ-RKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWE 1045
++ G + Q L E+ +V + K+ L+ + + ++ + + I WE
Sbjct: 659 EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE 718
Query: 1046 EMKTTL 1051
++ TT+
Sbjct: 719 QLLTTI 724
Score = 43.1 bits (100), Expect = 0.003
Identities = 41/189 (21%), Positives = 86/189 (45%), Gaps = 18/189 (9%)
Query: 1901 ESRRVRLVD-TGDKFRFFSMVRDLML-WMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKA 1958
E RR+ +D +KFR + + + E ++RQ + + +S ++ L+ H+ ++
Sbjct: 385 EIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442
Query: 1959 EIDARNDSFTTCIELGKSLLARKHYASEEIK----------EKLLQLTEKRKEMIDKWED 2008
++ A D + + L +Y S + + L LT+KR+E +++ E
Sbjct: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
Query: 2009 RWEWL-RLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAA 2067
E + +L LE +++ A+ W+ G L I +++E++ L HE F+ +
Sbjct: 503 LLETIDQLYLE---YAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLP 559
Query: 2068 TWDERFSAL 2076
D+ A+
Sbjct: 560 DADKERLAI 568
Score = 40.4 bits (93), Expect = 0.021
Identities = 35/153 (22%), Positives = 66/153 (43%), Gaps = 23/153 (15%)
Query: 2001 EMIDKWEDRW------EWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQS-VDEVE 2053
E ++K + W RL +F + AS+ EAW G+E L ++ + + E++
Sbjct: 372 EQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIK 431
Query: 2054 KLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEA 2113
L+K+HEAFE A +R ++ + ++ E + P K+ +
Sbjct: 432 ALLKKHEAFESDLAAHQDRVE--------QIAAIAQELNELDYYDSPSVNARCQKICD-- 481
Query: 2114 ESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD 2146
QWD ++Q A + + ++ ET+D
Sbjct: 482 ----QWDNLGA--LTQKRREALERTEKLLETID 508
Score = 38.5 bits (88), Expect = 0.079
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 1382 AELFTQSCADLDKWLHGLESQIQSDDYGK-DLTSVNILLKKQQMLENQMEVRKKEIEELQ 1440
AE F Q + + W G E+ ++ DY L+ + LLKK + E+ + + +E++
Sbjct: 396 AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIA 455
Query: 1441 SQAQALSQ 1448
+ AQ L++
Sbjct: 456 AIAQELNE 463
Score = 36.6 bits (83), Expect = 0.30
Identities = 33/157 (21%), Positives = 65/157 (41%), Gaps = 9/157 (5%)
Query: 1517 LQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL 1576
L ++ L+KK++ + ++ HQ R++ I +Q + + + ++ R + W
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQEL-NELDYYDSPSVNARCQKICDQWDN 485
Query: 1577 LIEETEKRHRRLEEAHR----AQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLK 1632
L T+KR LE + Q Y + A+ A + +M + + V ++
Sbjct: 486 LGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNN---WMEGAMEDLQDTFIVHTIE 542
Query: 1633 KHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669
+ Q L A E + T+ K R + H E +I
Sbjct: 543 EIQGLTTAHEQFKATLPDADK-ERLAILGIHNEVSKI 578
Score = 33.1 bits (74), Expect = 3.3
Identities = 29/137 (21%), Positives = 56/137 (40%), Gaps = 10/137 (7%)
Query: 1278 QKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWL--KHQAFMAELASNKEWLDKIEK 1335
+KF Q W + K + Y+ A K L KH+AF ++LA++++ +++I
Sbjct: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
Query: 1336 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-----EL---FTQ 1387
+L V + + W+ L + TQ + + L K +L + +
Sbjct: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
Query: 1388 SCADLDKWLHGLESQIQ 1404
A + W+ G +Q
Sbjct: 517 RAAPFNNWMEGAMEDLQ 533
>gi|4557241 actinin, alpha 3 [Homo sapiens]
Length = 901
Score = 432 bits (1111), Expect = e-120
Identities = 260/630 (41%), Positives = 372/630 (59%), Gaps = 35/630 (5%)
Query: 53 EAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHC 112
E Q+KTFT W NSHL + +I ++ D R+G L+ LLEV+SGERLP+P KG+MR H
Sbjct: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
Query: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEK 172
+ NV+KAL F+ + V L ++G+ +IVDGN ++TLG+IWTIILRF IQDISVE +
Sbjct: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVE------E 157
Query: 173 KSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHY 232
SAK+ LLLWCQ KTA Y NVN+ NF TSW+DG+A ALIH+HRPDLID+ KL+K +
Sbjct: 158 TSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIG 217
Query: 233 NLQNAFNLAEQHLGLTKLLDPEDI-SVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIG 291
NL AF +AE++L + K+LD EDI + PDEK+I+TYV +YH F+ + RI
Sbjct: 218 NLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRIC 277
Query: 292 KVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVE 351
KVL E EK++E+YE LAS+LLEWI +T+ L NR S+ +Q++L+ F YR +
Sbjct: 278 KVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLH 337
Query: 352 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 411
KPP+ EK LE+ T+Q+K+R +++ +MP EGKL+SDI AW LE+ E E L
Sbjct: 338 KPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLL 397
Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFD-LPAVEAATKKHEAIETD 470
+E+ R ++L+ LA +F +KA++ E W + ++SQ ++ L V A ++HEA E+D
Sbjct: 398 SEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESD 457
Query: 471 IAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLE-MNLG 529
+AA+++RV+ + A+A+EL +YH+ + +R + W+ L L + RR LE M
Sbjct: 458 LAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKL 517
Query: 530 LQKIFQEMLYIM-------DWMD------EMKVLVLSQDYGKHLLGVEDLLQKHTLVEAD 576
L+ I Q L +W+D + LV S + + LL D K TL EAD
Sbjct: 518 LETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQF-KATLPEAD 576
Query: 577 IGIQAERVRGVNASAQKFATDGEGYKPC--------DPQVIRDRVAHMEFCYQELCQLAA 628
+ + G+ QK G +PC PQ I + + Q
Sbjct: 577 --RERGAIMGIQGEIQKIC-QTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQ 633
Query: 629 ERRARLEESRRLWKFFWEMAEEEG-WIREK 657
E AR + + RL + F A G WI+ K
Sbjct: 634 EELARQQVNERLRRQFAAQANAIGPWIQAK 663
Score = 60.8 bits (146), Expect = 1e-08
Identities = 66/267 (24%), Positives = 109/267 (40%), Gaps = 32/267 (11%)
Query: 634 LEESRRLW-------KFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMR-LLSKHRAFED 685
L E RRL KF + + E W R KE++LS DY L +R LL +H AFE
Sbjct: 397 LSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFES 456
Query: 686 EMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA-- 743
+++ E +++ ++ + + R I +QW NL L+ R+ LE
Sbjct: 457 DLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEK 516
Query: 744 ------SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH---KDVAEEIA 794
L +F A + W+ ++ + + H TQSL+ H K E
Sbjct: 517 LLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEAD 576
Query: 795 NYRPTLDTLHEQASALPQEH-----AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTL 849
R + + + + Q + + +P + I ++ V +L R Q LQ+ L
Sbjct: 577 RERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEEL 636
Query: 850 A-------LYKMF-SEADACELWIDEK 868
A L + F ++A+A WI K
Sbjct: 637 ARQQVNERLRRQFAAQANAIGPWIQAK 663
Score = 43.9 bits (102), Expect = 0.002
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 7/86 (8%)
Query: 2001 EMIDKWEDRW------EWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSV-DEVE 2053
E ++K + W RL +F + AS+ EAW G+E LS R+ ++ EV
Sbjct: 386 EQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVR 445
Query: 2054 KLIKRHEAFEKSAATWDERFSALERL 2079
L++RHEAFE A +R + L
Sbjct: 446 ALLRRHEAFESDLAAHQDRVEHIAAL 471
Score = 43.5 bits (101), Expect = 0.002
Identities = 65/351 (18%), Positives = 132/351 (37%), Gaps = 30/351 (8%)
Query: 803 LHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE-ADAC 861
L + + +P E D+ G+E+ K + + LQ L + F + A
Sbjct: 361 LSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLH 420
Query: 862 ELWIDEKEQWLNNMQIPEKL-EDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGH 920
E W KE+ L+ L +++ + R E+ E ++ RV + +A++L +
Sbjct: 421 EAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDY 480
Query: 921 PSEKEIKAQQDKLNTRWSQFRELVDRKKDAL--LSAL--SIQNYHLE----CNETKSWI- 971
+ ++ + +W L +++DAL + L +I LE +W+
Sbjct: 481 HEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLD 540
Query: 972 -----REKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEH 1026
+ ++ S ++ + L + L +R+ AI ++QK +
Sbjct: 541 GAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRP 600
Query: 1027 PDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQ--------QFLRDLDDFQSWL 1078
I +I+ W+ ++ + +R+ +L E Q QF + W+
Sbjct: 601 CSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWI 660
Query: 1079 SRTQTAIA--SEDMPNTLTEAEKLLTQHE----NIKNEIDNYEEDYQKMRD 1123
+ + + +L E L Q E N K ID E D+Q +++
Sbjct: 661 QAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQE 711
Score = 40.0 bits (92), Expect = 0.027
Identities = 50/219 (22%), Positives = 89/219 (40%), Gaps = 35/219 (15%)
Query: 1884 KRENEVLEAWKSLLDA---------CESRRV-RLVDTGDKFRFFSMVRDLMLWMEDVIRQ 1933
K +++ AW+ L E RR+ RL +KFR + + + W R
Sbjct: 373 KLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEA--WT----RG 426
Query: 1934 IEAQEKPRDVSS-----VELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEI 1988
E RD S V L+ H+ ++++ A D L + L ++ + +
Sbjct: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASV 486
Query: 1989 KEK----------LLQLTEKRKEMIDKWEDRWEWL-RLILEVHQFSRDASVAEAWLLGQE 2037
+ L LT+KR++ +++ E E + +L LE F+R A+ WL G
Sbjct: 487 NSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE---FARRAAPFNNWLDGAV 543
Query: 2038 PYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL 2076
L + SV+E + L+ H+ F+ + D A+
Sbjct: 544 EDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAI 582
Score = 35.8 bits (81), Expect = 0.51
Identities = 30/138 (21%), Positives = 57/138 (41%), Gaps = 12/138 (8%)
Query: 1278 QKFLQDCQELSLWIN--EKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEK 1335
+KF Q W E+ML+ +D + + + +H+AF ++LA++++ ++ I
Sbjct: 411 EKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAA 470
Query: 1336 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL---------FDANKAELFT 1386
+L A V + + W+ L + TQ + L D + E F
Sbjct: 471 LAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE-FA 529
Query: 1387 QSCADLDKWLHGLESQIQ 1404
+ A + WL G +Q
Sbjct: 530 RRAAPFNNWLDGAVEDLQ 547
Score = 34.7 bits (78), Expect = 1.1
Identities = 18/68 (26%), Positives = 32/68 (47%), Gaps = 1/68 (1%)
Query: 1382 AELFTQSCADLDKWLHGLESQIQSDDYGKD-LTSVNILLKKQQMLENQMEVRKKEIEELQ 1440
AE F Q + + W G E + DY L V LL++ + E+ + + +E +
Sbjct: 410 AEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIA 469
Query: 1441 SQAQALSQ 1448
+ AQ L++
Sbjct: 470 ALAQELNE 477
>gi|4501893 actinin, alpha 2 [Homo sapiens]
Length = 894
Score = 431 bits (1108), Expect = e-120
Identities = 226/475 (47%), Positives = 314/475 (66%), Gaps = 8/475 (1%)
Query: 53 EAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHC 112
E Q+KTFT W NSHL + +I ++ D R+G L+ LLEV+SGERLPKP +G+MR H
Sbjct: 37 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHK 96
Query: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEK 172
+ NV+KAL ++ + V L ++G+ +IVDGN ++TLG+IWTIILRF IQDISVE +
Sbjct: 97 IANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVE------E 150
Query: 173 KSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHY 232
SAK+ LLLWCQ KTA Y NVNI NF TSW+DG+ ALIH+HRPDLID+ KL K +
Sbjct: 151 TSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIG 210
Query: 233 NLQNAFNLAEQHLGLTKLLDPEDI-SVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIG 291
N+ A +AE+HL + K+LD EDI + PDE++I+TYV +YH F+ + RI
Sbjct: 211 NINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRIC 270
Query: 292 KVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVE 351
KVL E E+++E+YE LAS+LLEWI +TI L NR ++ +Q++L+ F YR
Sbjct: 271 KVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKH 330
Query: 352 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 411
KPPK EK LE+ T+Q+K+R +N+ +MP EGK++SDI AW+RLE+AE E L
Sbjct: 331 KPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLL 390
Query: 412 NELIRQEKLEQLARRFDRKAAMRETW-LSENQRLVSQDNFGFDLPAVEAATKKHEAIETD 470
NE+ R E+LE LA +F +KA+ ETW + Q L+ +D L V A +KHEA E+D
Sbjct: 391 NEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESD 450
Query: 471 IAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLE 525
+AA+++RV+ + A+A+EL +YHD + R + W+ L L + RR+ LE
Sbjct: 451 LAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALE 505
Score = 76.6 bits (187), Expect = 3e-13
Identities = 78/316 (24%), Positives = 135/316 (42%), Gaps = 35/316 (11%)
Query: 601 YKPCDPQVIRD------RVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWI 654
+ P + +++ D R+ E Y+E R RLE KF + + E W
Sbjct: 360 FMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAE--KFRQKASTHETWA 417
Query: 655 REKEKILSSDDY-GKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSE 713
KE+IL DY LT V LL KH AFE +++ EQ +++ ++ +
Sbjct: 418 YGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAV 477
Query: 714 KIRERIIYIREQWANLEQLSAIRK-------KRLEEASLLH-QFQADADDIDAWMLDILK 765
+ +R I +QW L L+ R+ K LE LH +F A + WM ++
Sbjct: 478 NVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAME 537
Query: 766 IVSSSDVGHDEYSTQSLVKKH---KDVAEEIANYRPTLDTLHEQASALPQEH-----AES 817
+ + H QSL+ H K E R ++ + + + Q + + +
Sbjct: 538 DLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSN 597
Query: 818 PDVRGRLSGIEERYKEVAELTRLRKQALQDTLA-------LYKMF-SEADACELWIDEKE 869
P + + ++ +V +L +R Q+LQ+ LA L + F ++A+A WI K
Sbjct: 598 PYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKM 657
Query: 870 QWL--NNMQIPEKLED 883
+ + +++QI LED
Sbjct: 658 EEIARSSIQITGALED 673
Score = 62.4 bits (150), Expect = 5e-09
Identities = 104/552 (18%), Positives = 209/552 (37%), Gaps = 82/552 (14%)
Query: 728 NLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHK 787
N++ K L +L+H+ + D ++D K+ +G+ + + + +KH
Sbjct: 172 NIQNFHTSWKDGLGLCALIHRHRPD-------LIDYSKLNKDDPIGNINLAME-IAEKHL 223
Query: 788 DV-----AEEIANY-RPTLDTLHEQASALPQEHAESPDVRGRLSGI-------EERYKEV 834
D+ AE+I N +P + S A + + I +E + +
Sbjct: 224 DIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLM 283
Query: 835 AELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNN-------MQIPEKLEDLEVI 887
E RL + L+ WI WL N + +KLED
Sbjct: 284 EEYERLASELLE-----------------WIRRTIPWLENRTPEKTMQAMQKKLEDFR-- 324
Query: 888 QHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS--EKEIKAQQDKLNTRWSQFRELVD 945
+R + P++ + N + +L S P+ E K D + W + +
Sbjct: 325 DYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSD-IAGAWQRLEQAEK 383
Query: 946 RKKDALLSALS--------IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRK 997
++ LL+ + + + + + ++W K +++ L V AL RK
Sbjct: 384 GYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRK 443
Query: 998 LTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREAS 1057
E DL A + ++ + A++L A + R +I D W+ + T + R +
Sbjct: 444 HEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREA 503
Query: 1058 LGEASKLQQ--------FLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIK- 1108
L KL + F + F +W+ + + +++ E + L+T HE K
Sbjct: 504 LERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKA 563
Query: 1109 --NEIDNYEEDYQKMRDMGEMVTQG---QTDAQYMFLRQRLQALDTGWNELHKMW----E 1159
E D + +++ E V Q + + + + L T W+++ ++ +
Sbjct: 564 TLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQ 623
Query: 1160 NRQNLLSQSHAYQQFLRD-TKQAEA---FLNNQEYVLAHTEMPTT--LEGAEAAIKKQED 1213
+ Q L++ HA ++ R QA A ++ N+ +A + + T LE +K+ E
Sbjct: 624 SLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEH 683
Query: 1214 FMTTMDANEEKI 1225
+ N +K+
Sbjct: 684 NIINYKNNIDKL 695
Score = 55.8 bits (133), Expect = 5e-07
Identities = 89/435 (20%), Positives = 169/435 (38%), Gaps = 60/435 (13%)
Query: 741 EEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP-- 798
E L+ +++ A ++ W I + + + E + Q++ KK +D + ++P
Sbjct: 278 ENERLMEEYERLASELLEW---IRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPK 334
Query: 799 ------------TLDT---LHEQASALPQEHAESPDVRGRLSGIEERYKEVAE--LTRLR 841
TL T + + + +P E D+ G +E+ K E L +R
Sbjct: 335 VQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIR 394
Query: 842 KQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNN 900
+ + LA K +A E W KEQ L L ++ + + E+ E ++
Sbjct: 395 RLERLEHLA-EKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAA 453
Query: 901 QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDAL--LSAL--S 956
RV + IA++L + + + K+ +W + L ++++AL + L +
Sbjct: 454 HQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLET 513
Query: 957 IQNYHLECNET----KSWIREKTK---------VIESTQDLGNDLAGVMALQRKLTGMER 1003
I HLE + +W+ + IE Q L A + G +
Sbjct: 514 IDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQ 573
Query: 1004 DLVAIEAKLSD-LQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEAS 1062
++AI+ ++ +Q ++ S +P + E+ W+++K + R+ SL E
Sbjct: 574 SIMAIQNEVEKVIQSYNIRISSSNPYSTVT----MDELRTKWDKVKQLVPIRDQSLQEEL 629
Query: 1063 KLQ--------QFLRDLDDFQSWLSRTQTAIASEDMPNT--LTEAEKLLTQHE----NIK 1108
Q QF + W+ IA + T L + L Q+E N K
Sbjct: 630 ARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYK 689
Query: 1109 NEIDNYEEDYQKMRD 1123
N ID E D+Q +++
Sbjct: 690 NNIDKLEGDHQLIQE 704
Score = 50.8 bits (120), Expect = 2e-05
Identities = 71/319 (22%), Positives = 128/319 (40%), Gaps = 36/319 (11%)
Query: 511 EYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY-GKHLLGVEDLLQK 569
E+LL +R R +RLE +K Q+ W + ++L +DY L V LL+K
Sbjct: 387 EWLLNEIR-RLERLEHLA--EKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRK 443
Query: 570 HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAE 629
H E+D+ +RV + A AQ+ D + DR + + L L +
Sbjct: 444 HEAFESDLAAHQDRVEQIAAIAQEL----NELDYHDAVNVNDRCQKICDQWDRLGTLTQK 499
Query: 630 RRARLEESRRL--------WKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHR 681
RR LE +L +F A W+ + L + + L++ H
Sbjct: 500 RREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHE 559
Query: 682 AFEDEMSGRSGHFE--QAIKEGEDMIAEEHFGSEKIRERIIY-------IREQWANLEQL 732
F+ + G + AI+ + + + + + +I Y +R +W ++QL
Sbjct: 560 QFKATLPEADGERQSIMAIQNEVEKVIQSY--NIRISSSNPYSTVTMDELRTKWDKVKQL 617
Query: 733 SAIRKKRLEE--------ASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVK 784
IR + L+E L QF A A+ I W+ + ++ ++ S + + + +
Sbjct: 618 VPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSI-QITGALEDQMN 676
Query: 785 KHKDVAEEIANYRPTLDTL 803
+ K I NY+ +D L
Sbjct: 677 QLKQYEHNIINYKNNIDKL 695
Score = 50.4 bits (119), Expect = 2e-05
Identities = 58/304 (19%), Positives = 128/304 (42%), Gaps = 59/304 (19%)
Query: 1884 KRENEVLEAWKSLLDA---------CESRRV-RLVDTGDKFRFFSMVRDLMLWMEDVIRQ 1933
K +++ AW+ L A E RR+ RL +KFR + + + ++ I
Sbjct: 366 KMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQIL- 424
Query: 1934 IEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEK-- 1991
++ + ++ V L+ H+ ++++ A D + + L ++ + + ++
Sbjct: 425 LQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQ 484
Query: 1992 --------LLQLTEKRKEMIDKWEDRWEWLRLILEVH-QFSRDASVAEAWLLGQEPYLSS 2042
L LT+KR+E +++ E + L I ++H +F++ A+ W+ G L
Sbjct: 485 KICDQWDRLGTLTQKRREALERME---KLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQD 541
Query: 2043 REIGQSVDEVEKLIKRHEAF---------------------EKSAATWDERFSALERLTT 2081
I S++E++ LI HE F EK +++ R S+ +T
Sbjct: 542 MFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYST 601
Query: 2082 L-------------ELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVS 2128
+ +L+ +R Q +EE R+ + + + +A + W +K E+++
Sbjct: 602 VTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIA 661
Query: 2129 QNGL 2132
++ +
Sbjct: 662 RSSI 665
Score = 42.7 bits (99), Expect = 0.004
Identities = 40/237 (16%), Positives = 99/237 (41%), Gaps = 11/237 (4%)
Query: 301 EKMIEKYESL-------ASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKP 353
EK++E + L A+ W+E + L + +S+ +Q + A ++ P
Sbjct: 508 EKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKAT-LP 566
Query: 354 PKFTEKGNLEVLLFTIQSKMRANNQKVYM--PREGKLISDINKAWERLEKAEHERELALR 411
E+ ++ + ++ +++ N ++ P + ++ W+++++ R+ +L+
Sbjct: 567 EADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQ 626
Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDI 471
EL RQ E+L R+F +A W+ +++ + A+E + + E +I
Sbjct: 627 EELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQI-TGALEDQMNQLKQYEHNI 685
Query: 472 AAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNL 528
Y+ + + + ++ D K +++ WE LL + +E +
Sbjct: 686 INYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQI 742
Score = 42.0 bits (97), Expect = 0.007
Identities = 71/322 (22%), Positives = 132/322 (40%), Gaps = 55/322 (17%)
Query: 1382 AELFTQSCADLDKWLHGLESQIQSDDY-GKDLTSVNILLKKQQMLENQMEVRKKEIEELQ 1440
AE F Q + + W +G E + DY LT V LL+K + E+ + + +E++
Sbjct: 403 AEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIA 462
Query: 1441 SQAQALSQEG------------KSTDEVD------SKRLTVQTKFMELLEPLNERKHNLL 1482
+ AQ L++ K D+ D KR + +LLE +++ +L
Sbjct: 463 AIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQL--HLE 520
Query: 1483 ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL----------QK 1532
+K FN W+ M H+++ +Q LI ++ ++
Sbjct: 521 FAKRAAPFNN-------WMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQ 573
Query: 1533 EIQGHQPRIDDIFERSQNIVTDS----SSLSAEAIRQRLADLKQLWGLLIEETEKRHRRL 1588
I Q ++ + + S NI S S+++ + +R + +KQL + + ++ R
Sbjct: 574 SIMAIQNEVEKVIQ-SYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQ 632
Query: 1589 EEAHRAQQYYFDAAEAEA---WMSE--QELYMMSEEKAKDEQSAVSMLK--KHQILEQAV 1641
R ++ + AA+A A W+ +E+ S + + ++ LK +H I+
Sbjct: 633 HANERLRRQF--AAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKN 690
Query: 1642 E-DYAETVHQLSKTSRALVADS 1662
D E HQL ALV D+
Sbjct: 691 NIDKLEGDHQL--IQEALVFDN 710
Score = 37.7 bits (86), Expect = 0.13
Identities = 63/332 (18%), Positives = 123/332 (37%), Gaps = 48/332 (14%)
Query: 1278 QKFLQDCQELSLWI--NEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEK 1335
+KF Q W E++L +D + + KH+AF ++LA++++ +++I
Sbjct: 404 EKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAA 463
Query: 1336 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-----EL---FTQ 1387
+L V ++ + W+ L + TQ + + L K +L F +
Sbjct: 464 IAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAK 523
Query: 1388 SCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALS 1447
A + W+ G +Q D+ V+ IEE+QS A
Sbjct: 524 RAAPFNNWMEGAMEDLQ------DMFIVH------------------SIEEIQSLITAHE 559
Query: 1448 QEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILW--VGERM 1505
Q + E D +R ++ E+ + + + +S D E W V + +
Sbjct: 560 QFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMD-ELRTKWDKVKQLV 618
Query: 1506 PLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQ 1565
P+ +LQ N+ L+++ I + + SS A+
Sbjct: 619 PI-----RDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALED 673
Query: 1566 RLADLKQL------WGLLIEETEKRHRRLEEA 1591
++ LKQ + I++ E H+ ++EA
Sbjct: 674 QMNQLKQYEHNIINYKNNIDKLEGDHQLIQEA 705
Score = 36.2 bits (82), Expect = 0.39
Identities = 39/203 (19%), Positives = 83/203 (40%), Gaps = 23/203 (11%)
Query: 1839 VETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLD 1898
V L R H FE D+ A +V Q+ A L D A ++ R ++ + W L
Sbjct: 437 VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHD-AVNVNDRCQKICDQWDRLGT 495
Query: 1899 ACESRR------VRLVDTGDK--FRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLM 1950
+ RR +L++T D+ F WME + ++ + ++ L+
Sbjct: 496 LTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLI 555
Query: 1951 NNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKR---KEMIDKWE 2007
H+ KA + + +S++A ++ + I+ ++++ +D+
Sbjct: 556 TAHEQFKATLPEADGE-------RQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELR 608
Query: 2008 DRWEWLRLILEVHQFSRDASVAE 2030
+W+ ++ ++ + RD S+ E
Sbjct: 609 TKWDKVKQLVPI----RDQSLQE 627
Score = 36.2 bits (82), Expect = 0.39
Identities = 30/143 (20%), Positives = 56/143 (39%), Gaps = 7/143 (4%)
Query: 396 WERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLP 455
W+RL +R AL E ++QL F ++AA W+ + +
Sbjct: 490 WDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIE 549
Query: 456 AVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRI-------TARKDNVIR 508
+++ HE + + + Q+++A+ E+E RI T D +
Sbjct: 550 EIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
Query: 509 LWEYLLELLRARRQRLEMNLGLQ 531
W+ + +L+ R Q L+ L Q
Sbjct: 610 KWDKVKQLVPIRDQSLQEELARQ 632
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 404 bits (1039), Expect = e-112
Identities = 577/2483 (23%), Positives = 1025/2483 (41%), Gaps = 325/2483 (13%)
Query: 42 RSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLP 101
++ I +L DER+ VQKKTFTKWVN HL + I+DLY DLRDG LI LLEVLSG+ LP
Sbjct: 8 QNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLP 67
Query: 102 KPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQD 161
+ KGRMR H L+NV AL +L+ ++V L N+ + DI DGN +LTLGLIWTIIL FQI D
Sbjct: 68 RE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 126
Query: 162 ISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLID 221
I V + E +AK+ LLLW Q GY + NFT+SWRDG FNA+IH+H+P LID
Sbjct: 127 IQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLID 184
Query: 222 FDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMK 281
+K+ + NL AF++AE+ LG+T+LLDPED+ V PDEKSIITYV + Y ++
Sbjct: 185 MNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVP 244
Query: 282 ALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQL 341
+ +G R A E + ++Y L LL+W+ R+F +S ++
Sbjct: 245 DVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILW 296
Query: 342 QAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEK 401
F ++ +E P K +K + + +++ ++A KV G D+ K W +L
Sbjct: 297 SQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHV 353
Query: 402 AEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAAT 461
A ERE LR+E R E L+++ + +A + E L++ L+ D L A
Sbjct: 354 AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVP 410
Query: 462 KKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARR 521
++ +E D+ + ++ + + L+ + +++ R V RL E L+ +
Sbjct: 411 QRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHERLVAIRTEYN 467
Query: 522 QRLEMNLG----------LQKIFQE-------MLYIMD---WMDEMKVLVLSQDYGKHLL 561
RL+ + LQ + + + Y+ D W++E + V ++G L
Sbjct: 468 LRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLP 527
Query: 562 GVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQ 621
VE L H + + + A ++ +D P RD + ++ Y
Sbjct: 528 SVEAQLGSHRGLH-------QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA 580
Query: 622 ELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHR 681
+L +ARL L F +E W+ EKE+ D+ T++ +
Sbjct: 581 KLLN---SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYS 637
Query: 682 AFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLE 741
A E+ + ++ G+ ++ E+H + ++ QW+ + QL + L+
Sbjct: 638 ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 697
Query: 742 EASLLHQFQADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 798
E + QF +D + + + + L+ S D + L++ +D E++ Y+
Sbjct: 698 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 757
Query: 799 TLDTLHEQASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQALQDTLALYKMF 855
L L ++A A+ Q P +RGRL + YK+V E+T
Sbjct: 758 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT----------------V 800
Query: 856 SEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQL 915
+ D C+L P + +V+ E + + V NQ A++
Sbjct: 801 HKGDECQL------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLVPPPNQEAQEA 846
Query: 916 MHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKT 975
+ ++AQ L T W Q VD K S L+ Q+ + +SW
Sbjct: 847 V-------TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQLIRSWSLATF 892
Query: 976 KVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILS 1035
+ ++ + + L ++E ++++ P+
Sbjct: 893 RTLKPEE------------------QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 934
Query: 1036 RLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA--------- 1086
S ++++ L++ E E S+ Q+ + +L D + L +T
Sbjct: 935 EYGSCSHHYQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 991
Query: 1087 --SEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRL 1144
+ + + E +K + E + + + +K+ + E T LR L
Sbjct: 992 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT------LRSEL 1045
Query: 1145 QALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-MPTT--- 1200
+ L G +L ++ L + +R T+ AE L E L + +P T
Sbjct: 1046 E-LTLG--KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE 1102
Query: 1201 LEGAEAAIKK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINSDRIQEKVDSI 1253
LE +A++KK E T DA +++ E G RL + ++ +R +E+V +
Sbjct: 1103 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL 1162
Query: 1254 DDRHRKNRETASELLMRLKD-NRDLQKFLQDCQELSLWINE---KMLTAQDMSYDEARNL 1309
+R + L+ R L+ + + L W+ + + Q M +++ +
Sbjct: 1163 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1222
Query: 1310 HSKWLKHQAFMAELASN-----------KEWLDKIEKEGMQLISEKPETEAVVKEKLTGL 1358
+ + QA + E+ + K++++ I+ +QL++ K + E V
Sbjct: 1223 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP--AKK 1280
Query: 1359 HKMWEVLESTTQTKAQ-RLFDANKAELFTQSCADLDKWLHGLE-----SQIQSDDYGKDL 1412
K+ ES Q R + L +Q + + L +E ++ Q + + L
Sbjct: 1281 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1340
Query: 1413 TSVNILLKKQQML-------ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT 1465
V L+KQ+ L + Q E KE+++ + Q + + +E + D KR ++Q
Sbjct: 1341 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKR-SIQE 1398
Query: 1466 KFMELLEPLNERKHNLLASKEIHQFNR-DVEDEILWVGERMPLATSTDHG---HNLQTVQ 1521
+ +L + E + +R +E+EI V ++ AT G LQ ++
Sbjct: 1399 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE-ATERQRGGAEGELQALR 1457
Query: 1522 LLIKKNQTLQKEIQGHQPR----IDDIFERSQNIVTDSSS---LSAEAIRQRLADLKQLW 1574
++ + +++ Q R + D +R + + +S AEA R++ L+ L
Sbjct: 1458 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1517
Query: 1575 GLLI--EETEKRHRRLE-EAHRAQQYYFDAAE--AEAWMSEQ-----ELYMMSEEKAKDE 1624
L + EE E+R R+ E E R Q + A+ AEA + + E E ++E
Sbjct: 1518 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1577
Query: 1625 QSAVSMLKK---------------HQILEQAVEDY-------------AETVHQLSKTSR 1656
AV+ L++ + E+ +E + AE V Q ++
Sbjct: 1578 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1637
Query: 1657 ALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAE 1716
A E+ER + R+ K ++ ++LAE+ +L+++ +L + + ++ AE
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ---ELEKQRQLAEGTAQ----QRLAAE 1690
Query: 1717 REVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLAD-----ELINSGHS 1771
+E++ E Q + +L+E R+ Q+R + LA E++ + +
Sbjct: 1691 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1750
Query: 1772 DA-----ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQ-DKH 1825
A +T + K L EL + ++ A + E + A+E R + +
Sbjct: 1751 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1810
Query: 1826 KKLPEELGRDQNTVETLQRMHTTFE---HDIQALGTQVRQLQEDAA----RLQAAYAGDK 1878
+ L E+L + R+ T E + +A ++R+L ED A RL+ A K
Sbjct: 1811 RVLAEKLA----AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1866
Query: 1879 AD------DIQKRENEVLEAWKSLL-DACESRR------VRLVDTGDKFRFFSMVRDLML 1925
AD ++K + LE K L+ D RR + L + +K +L L
Sbjct: 1867 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1926
Query: 1926 WMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL-----LAR 1980
IR A++ R EL + + AE + R ++ KSL AR
Sbjct: 1927 GR---IRS-NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAAR 1980
Query: 1981 KHYASEEIKEKLLQLTEKRKEMIDKWE-DRWEWLRLILEVHQFSRDA-SVAEAWLLGQEP 2038
+ A+ E E+L E+ + + ++ E + L+L E Q A A A+ + Q+
Sbjct: 1981 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2040
Query: 2039 YLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKR 2098
+ + Q +++L EA ++A +E ER E + RRQ EE ER +
Sbjct: 2041 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER----EAAQSRRQVEEAERLK 2096
Query: 2099 RPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDT----------- 2147
+ S E + +A++ + + EQ + AEQ + R + D
Sbjct: 2097 Q--SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2154
Query: 2148 -----SEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQE---TPSAQ 2199
+++ T R +E+ + + + A AA ++ +E + Q
Sbjct: 2155 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2214
Query: 2200 MEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTA---------ASGIPYH 2250
ME K EA N+ R N + + + A+ A A+ +
Sbjct: 2215 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2274
Query: 2251 SEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKD-DEEMNTWIQAISSAISSD 2309
+E ++ + A+ E L K + RL E L Q K+ +E +Q ++
Sbjct: 2275 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2334
Query: 2310 KHEVSASTQSTPASSRAQTLPTS 2332
E + Q T + R + L S
Sbjct: 2335 LAEETQGFQRTLEAERQRQLEMS 2357
Score = 103 bits (257), Expect = 2e-21
Identities = 324/1635 (19%), Positives = 647/1635 (39%), Gaps = 194/1635 (11%)
Query: 677 LSKHRAFEDEMSGRSGHFEQAIKEGEDMIA--EEHFGSEKIRERIIYIREQWANLEQLSA 734
+++ + + E+ G + E E ++A E + +R + + + LSA
Sbjct: 1001 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1060
Query: 735 IRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEY-STQSLVKKHKDVAEEI 793
I ++L+ SL+ + A+++ + LK + E +T++ +KK + AE
Sbjct: 1061 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA- 1119
Query: 794 ANYRPTLDTLHEQ-------ASALPQEHAESPDV-----RGRLSGIEERYKEVAELTRLR 841
+PT D L ++ L Q H E DV R R++ + ER++ V T +R
Sbjct: 1120 --QQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERWRERVAQLLERWQAVLAQTDVR 1176
Query: 842 KQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPE 897
++ L+ + + E AD W+ + + +Q L D + ++ + ++L E
Sbjct: 1177 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-LADSQAVREQLRQEQALLEE 1235
Query: 898 MNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRE--LVDRKKDALLSAL 955
+ +V + A+Q +++ E ++ + +L S ++ + + + +
Sbjct: 1236 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1295
Query: 956 SIQNYHLECNETKS----WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 1011
++ ++ E S +I E + +E + L A Q++ ER L +EA
Sbjct: 1296 DLRTHYSELTTLTSQYIKFISETLRRMEEEERL--------AEQQRAEERER-LAEVEAA 1346
Query: 1012 LSDLQKEAE---KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFL 1068
L ++ AE + +++ +A+ + R+ E EE + ++ S+ E +LQQ L
Sbjct: 1347 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE--ELQQ-L 1403
Query: 1069 RDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV 1128
R + + Q A E + Q E + + E + Q +R E
Sbjct: 1404 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1463
Query: 1129 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQ 1188
+ AQ R R Q D E + + L S+ A + R+ ++A L +
Sbjct: 1464 EAQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEAEAAREKQRALQAL--E 1517
Query: 1189 EYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQE 1248
E L E L AE +++ ++ + A +++ R ++ +R
Sbjct: 1518 ELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1572
Query: 1249 KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-ELSLWINEKMLTAQDMSYDEAR 1307
S+ + H + E R + + ++ ++ + EL W + +EA
Sbjct: 1573 ---SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW---------QLKANEAL 1620
Query: 1308 NLH--SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTG--LHKMWE 1363
L ++ + Q +A+ + K+ K E E K E +AV + +L L K +
Sbjct: 1621 RLRLQAEEVAQQKSLAQAEAEKQ---KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1677
Query: 1364 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1423
+ E T Q QRL A + EL A+ ++ + Q+ ++ + +K+Q
Sbjct: 1678 LAEGTAQ---QRL--AAEQELIRLR-AETEQGEQ--QRQLLEEELARLQREAAAATQKRQ 1729
Query: 1424 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT-KFMELLEPLN------- 1475
LE ++ + E+E L + +E +ST E +RL + +F EL E
Sbjct: 1730 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1789
Query: 1476 --ERKHNLL---ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL 1530
+R+ L A+++ + R + +++ +GE L T + + +K+ +
Sbjct: 1790 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---------IALKEKEAE 1840
Query: 1531 QKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL-------LIEETEK 1583
+ ++ + D+ F+R + + + ++ I +RLA L++ L+E+T +
Sbjct: 1841 NERLR--RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1896
Query: 1584 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-----EQSAVSMLKKHQILE 1638
+ R++EE A + F+ A A E EL + A+D EQ+ + ++ Q+
Sbjct: 1897 QRRQVEEEILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAARQRQL-- 1953
Query: 1639 QAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERH 1698
A E+ + ++L A+ +R + + +V++L A +++ R E
Sbjct: 1954 -AAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESA 2011
Query: 1699 RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTV 1758
R QL +E E+ + Q+ + ++ + R + +
Sbjct: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE- 2070
Query: 1759 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA---- 1814
A+E +AA + E R Q AA+ +L K
Sbjct: 2071 ---AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2127
Query: 1815 ----------KEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQ 1864
K+ +KHKK E+ R + VE + TT ++ Q L
Sbjct: 2128 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE---QELTTLRLQLEETDHQKNLLD 2184
Query: 1865 EDAARL--QAAYAGDKADDIQKR------ENEVLEAWKSLLDACESRRVRLVDTGDKFRF 1916
E+ RL +A A + +++ + E L K+ ++A E+R + L D + RF
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRF 2243
Query: 1917 FSMVRDLMLWM-EDVIR-QIEAQE--KPRDVSSVELLMNN---HQGIKAEIDARNDSFTT 1969
+ M + E+ R + AQE + R ++ +L + +K ++ A ++ T
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA--T 2301
Query: 1970 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2029
++ LL ++ E +E+ +L E +++M + + + + LE + + A
Sbjct: 2302 RLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2358
Query: 2030 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLEVR 2088
EA L SR ++ ++ ++ K+ E EK T + E++T ++ LE++
Sbjct: 2359 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQ 2415
Query: 2089 RQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD-- 2146
RQQ + + +R E ++ E E QQ +K Q+ + Q + ET
Sbjct: 2416 RQQSDHDAER---LREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLLQETQALQ 2470
Query: 2147 ---TSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPS------ 2197
SE + +R +E + + D AK AQ R Q+
Sbjct: 2471 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK----AQQLREEQQRQQQQMEQERQRL 2526
Query: 2198 -AQMEGFLNRKHEWE 2211
A ME R+HE E
Sbjct: 2527 VASMEEARRRQHEAE 2541
Score = 100 bits (250), Expect = 1e-20
Identities = 306/1580 (19%), Positives = 623/1580 (39%), Gaps = 215/1580 (13%)
Query: 713 EKIRERIIYIREQWANLEQLSAIRKKRLEEASL-LHQFQADADDIDAWMLDI-------- 763
E+ RER+ + E+W + + +R++ LE+ L ++ AD + AW+ D
Sbjct: 1153 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1212
Query: 764 -LKIVSSSDVGHDEYSTQSL---VKKHKDVAEE-----------IANYRPTLDTLHEQAS 808
+ + S V Q+L +++H + EE I +Y L T Q
Sbjct: 1213 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1272
Query: 809 ALPQEHAESPDVRGRLSGIEERYKEV----AELTRLRKQALQDTLALYKMFSEADACELW 864
+ A+ P V+ + + Y ++ +ELT L Q + K SE L
Sbjct: 1273 PVASP-AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI-------KFISET----LR 1320
Query: 865 IDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS-- 922
E+E+ L Q E+ E L ++ E A A + A++L
Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380
Query: 923 ---EKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIE 979
E + AQQ K + + + + + + +A + A + Q E + + I E+ +V+
Sbjct: 1381 RREEAAVDAQQQKRSIQ--EELQQLRQSSEAEIQAKARQAEAAERSRLR--IEEEIRVVR 1436
Query: 980 STQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL-------QKEAEKLESEHPDQAQA 1032
+ A +R+ G E +L A+ A+ + Q+EAE+L + D++Q
Sbjct: 1437 LQLE---------ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487
Query: 1033 -------ILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLD-----DFQSWLSR 1080
+ SR+ ++ E + L+ E +A + ++ LR + Q L
Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1547
Query: 1081 TQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFL 1140
Q + +E + AEK +++ E ++R+ E Q Q +A+
Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEE----HVAVAQLREEAERRAQQQAEAE---- 1599
Query: 1141 RQRLQALDTGWNELHKMWENRQN------LLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH 1194
+A + EL + W+ + N L ++ A Q+ L QAEA +E A
Sbjct: 1600 ----RAREEAERELER-WQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQKEE---AE 1648
Query: 1195 TEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSID 1254
E + E A++++E + + +++ A +RL ++ + R +
Sbjct: 1649 REARRRGKAEEQAVRQRE--LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET------ 1700
Query: 1255 DRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWIN------EKMLTAQDMSYDEARN 1308
++ + R+ E L RL+ R+ Q QEL + E +L ++ + +E+R+
Sbjct: 1701 EQGEQQRQLLEEELARLQ--REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1758
Query: 1309 LHSKW---LKHQAF----MAELASNKEWLDKIEKEGMQLISE-----KPETEAVVKEKLT 1356
K L+ +A +AE A+ L + K QL E + E E V+ EKL
Sbjct: 1759 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818
Query: 1357 GLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVN 1416
+ + + +T+A+ +AE D+ + Q+ + D+
Sbjct: 1819 AIGEATRL-----KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1873
Query: 1417 ILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNE 1476
L+K ++++E +K +E+ Q + + +E + K + + L +
Sbjct: 1874 AQLRKAS--DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1931
Query: 1477 RKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQG 1536
+ L SKE + + ++ ER +L + ++ + +E++
Sbjct: 1932 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991
Query: 1537 HQPRIDD---IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHR 1593
+ ++++ + ER++ L+ EA ++RL ++ +++ E+ L++ +
Sbjct: 1992 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE---LQQTLQ 2048
Query: 1594 AQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVS---MLKKHQILEQAVEDYAETVHQ 1650
+Q D EA + + E + + E+ A +++ + L+Q+ E+ A+ Q
Sbjct: 2049 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2108
Query: 1651 LSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLF--QLNREVD 1708
+ L E+E+ + R+++ ++ K A+ E+H+ F Q R+
Sbjct: 2109 AQAAAEKL----RKEAEQEAARRAQAEQAALRQKQAADAEM----EKHKKFAEQTLRQKA 2160
Query: 1709 DLEQWIA--EREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDT---VNHLAD 1763
+EQ + ++ H+ E + L+ E AR + +E + L+
Sbjct: 2161 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2220
Query: 1764 ELINSGHSDAATIAEWKDG----LNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFG 1819
+ A I KD L E + ++ + ++ A+ E + A+E
Sbjct: 2221 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2280
Query: 1820 RIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKA 1879
+ + +K+ +E ++ +Q T + + + L Q QE A RLQ DK
Sbjct: 2281 QQRALAEKMLKE------KMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQE----DKE 2329
Query: 1880 DDIQKRENEVLEAWKSLLDACESRRVRLVDTGD--KFRFFSMVRDLMLWMEDVIR-QIEA 1936
Q+ E + ++ L+A R++ + + K R M R ED R + +A
Sbjct: 2330 QMAQQLAEET-QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2388
Query: 1937 QEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLT 1996
+E + EL + ++ + + + +E ++E + +L
Sbjct: 2389 EEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------QSDHDAERLREAIAEL- 2433
Query: 1997 EKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLI 2056
E+ KE K + + L+L E Q + + + Q+ +LS E + L+
Sbjct: 2434 EREKE---KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---------EKDSLL 2481
Query: 2057 KRHEAFEKSAATWDERFS-ALERLTTLELLEVRRQQE-EEERKRRPPSPEPSTKVSEEAE 2114
+R E+ A ++ F + + L + R+QQ+ E+ER+R S E + + EAE
Sbjct: 2482 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2541
Query: 2115 -----SQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPS 2169
Q++ + ++ Q L AE+ + R+ E + E + A + +S + +
Sbjct: 2542 EGVRRKQEELQQLEQQRRQQEELLAEE-NQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2600
Query: 2170 PTSDRKAKTALPAQSAATLP 2189
+ + AL +A P
Sbjct: 2601 TKTLPNGRDALDGPAAEAEP 2620
Score = 100 bits (249), Expect = 2e-20
Identities = 307/1564 (19%), Positives = 623/1564 (39%), Gaps = 209/1564 (13%)
Query: 384 REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLAR--RFDRKAA-MRETWLSE 440
R G+ ++ + ER+ + + L +RQ +LEQL R R+ R++A WL +
Sbjct: 1144 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1203
Query: 441 NQRLVSQDNFG--FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKR 498
+R Q D AV ++ +A+ +I + E+V+ A++
Sbjct: 1204 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY---------- 1253
Query: 499 ITARKDNVIRLWEY--LLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 556
I A KD ++L Y LE + + ++ ++ G + + QE + + E+ L+ Y
Sbjct: 1254 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL--TTLTSQY 1311
Query: 557 GKHLL-GVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAH 615
K + + + ++ L E + ER+ V A+ +K E + Q R+
Sbjct: 1312 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1371
Query: 616 MEFCYQELCQ-------LAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGK 668
+ +E+ + ++R+ EE ++L + AE + R+ E S +
Sbjct: 1372 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SEAEIQAKARQAEAAERSRLRIE 1429
Query: 669 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG---SEKIRERI--IYIR 723
+ V+RL + A E + G G + E+ A++ +E++R ++ R
Sbjct: 1430 EEIRVVRL--QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487
Query: 724 EQWANLEQLSAIR------KKRLEEASLLHQFQADADDIDAWM----LDILKIVSSSDVG 773
++ A +E S ++ +++ L + + A++ + + ++ + V +
Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1547
Query: 774 HDEYSTQSLVKKHKDVAEEIANYRPTLDTLH-------EQASALPQEHAESPDVRGRLSG 826
+ L K AE+ A +L H E+A Q+ AE+ R
Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1607
Query: 827 IEERYK-EVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 885
ER++ + E RLR QA + +A K ++A+A + +KE+ + K E+
Sbjct: 1608 ELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQA 1661
Query: 886 VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 945
V Q E E Q + ++A + +E E QQ +L EL
Sbjct: 1662 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELAR 1716
Query: 946 RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL-----TG 1000
+++A +A + + LE K +R + +V+ +++ + + + + K G
Sbjct: 1717 LQREA--AAATQKRQELEAELAK--VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1772
Query: 1001 MERDLVAIEAKLSDLQKEA--------EKLESEHPDQAQAILSRLAEISDVWE---EMKT 1049
R+L A+L L +EA E + + + + +LA I + E +
Sbjct: 1773 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1832
Query: 1050 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1109
LK +EA E +L++ D + FQ Q A D+ L + K ++
Sbjct: 1833 ALKEKEA---ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRK--ASDSELER 1886
Query: 1110 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH-KMWENRQNLLSQS 1168
+ E+ ++ R Q + + + L+ + G EL ++ R N
Sbjct: 1887 QKGLVEDTLRQRR---------QVEEEILALKASFEKAAAGKAELELELGRIRSNA---- 1933
Query: 1169 HAYQQFLRDTKQAEAFLNNQEYVLAHTE---------MPTTLEGAEAAIKKQEDFMTTMD 1219
+ LR +QAE Q + A E + +L E A ++++ + +
Sbjct: 1934 ---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV- 1989
Query: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1279
E++ A VE RRL S R + + + E A ++ K+ ++LQ+
Sbjct: 1990 ---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQ 2045
Query: 1280 FLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ 1339
LQ Q + +++ + + A ++ + A+ E +++++ +
Sbjct: 2046 TLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2101
Query: 1340 LISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH-- 1397
+ + +A E L + +A R A +A L + AD + H
Sbjct: 2102 QAQARAQAQAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2150
Query: 1398 -GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA-QALSQEGKSTDE 1455
++ Q ++LT++ + L++ ++Q + +E++ L+++A +A Q + +E
Sbjct: 2151 FAEQTLRQKAQVEQELTTLRLQLEE---TDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2207
Query: 1456 VDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH 1515
+ S R VQ + + L+ E ++ L ++ R +++E E+M + +
Sbjct: 2208 LFSVR--VQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMK-QVAEEAAR 2260
Query: 1516 NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA------------- 1562
Q + Q ++++ + + + + V +++ L AEA
Sbjct: 2261 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2320
Query: 1563 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1622
R+ D +Q+ L EET+ R L EA R +Q AEA + + MS +A+
Sbjct: 2321 ARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQL---EMSAEAERLKLRVAEMSRAQAR 2376
Query: 1623 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVD--KLY 1680
E+ A Q + E+ E +H+ ++ V + ++ I +QS D +L
Sbjct: 2377 AEEDA-------QRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQSDHDAERLR 2427
Query: 1681 AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDY--EHVTMLQ- 1737
+ +L E+ KL + +L QL E Q + + +++ + L Q + E ++LQ
Sbjct: 2428 EAIAELEREKE-KLQQEAKLLQLKSEE---MQTVQQEQLLQETQALQQSFLSEKDSLLQR 2483
Query: 1738 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1797
ERF I QE+ DE +A+ + E ++ R
Sbjct: 2484 ERF---------IEQEKAKLEQLFQDE-----------VAKAQQLREEQQRQQQQMEQER 2523
Query: 1798 TQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALG 1857
+++A+ E + H+A+E R Q++ ++L ++ + + E L + +Q L
Sbjct: 2524 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE---ELLAEENQRLREQLQLLE 2580
Query: 1858 TQVR 1861
Q R
Sbjct: 2581 EQHR 2584
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 404 bits (1037), Expect = e-112
Identities = 579/2484 (23%), Positives = 1027/2484 (41%), Gaps = 326/2484 (13%)
Query: 41 ERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERL 100
ER+ I+ +ADER+ VQKKTFTKWVN HL + I+DLY DLRDG LI LLEVLSG+ L
Sbjct: 57 ERAVIR-IADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSL 115
Query: 101 PKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQ 160
P+ KGRMR H L+NV AL +L+ ++V L N+ + DI DGN +LTLGLIWTIIL FQI
Sbjct: 116 PRE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS 174
Query: 161 DISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLI 220
DI V + E +AK+ LLLW Q GY + NFT+SWRDG FNA+IH+H+P LI
Sbjct: 175 DIQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLI 232
Query: 221 DFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKM 280
D +K+ + NL AF++AE+ LG+T+LLDPED+ V PDEKSIITYV + Y ++
Sbjct: 233 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 292
Query: 281 KALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQ 340
+ +G R A E + ++Y L LL+W+ R+F +S ++
Sbjct: 293 PDVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEIL 344
Query: 341 LQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLE 400
F ++ +E P K +K + + +++ ++A KV G D+ K W +L
Sbjct: 345 WSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLH 401
Query: 401 KAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAA 460
A ERE LR+E R E L+++ + +A + E L++ L+ D L A
Sbjct: 402 VAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKV 458
Query: 461 TKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRAR 520
++ +E D+ + ++ + + L+ + +++ R V RL E L+ +
Sbjct: 459 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHERLVAIRTEY 515
Query: 521 RQRLEMNLG----------LQKIFQE-------MLYIMD---WMDEMKVLVLSQDYGKHL 560
RL+ + LQ + + + Y+ D W++E + V ++G L
Sbjct: 516 NLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDL 575
Query: 561 LGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCY 620
VE L H + + + A ++ +D P RD + ++ Y
Sbjct: 576 PSVEAQLGSHRGLH-------QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQY 628
Query: 621 QELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKH 680
+L +ARL L F +E W+ EKE+ D+ T++ +
Sbjct: 629 AKLLN---SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 685
Query: 681 RAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRL 740
A E+ + ++ G+ ++ E+H + ++ QW+ + QL + L
Sbjct: 686 SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 745
Query: 741 EEASLLHQFQADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYR 797
+E + QF +D + + + + L+ S D + L++ +D E++ Y+
Sbjct: 746 KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 805
Query: 798 PTLDTLHEQASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQALQDTLALYKM 854
L L ++A A+ Q P +RGRL + YK+V E+T
Sbjct: 806 GHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT---------------- 848
Query: 855 FSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQ 914
+ D C+L P + +V+ E + + V NQ A++
Sbjct: 849 VHKGDECQL------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLVPPPNQEAQE 894
Query: 915 LMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREK 974
+ ++AQ L T W Q VD K S L+ Q+ + +SW
Sbjct: 895 AV-------TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQLIRSWSLAT 940
Query: 975 TKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAIL 1034
+ ++ + + L ++E ++++ P+
Sbjct: 941 FRTLKPEE------------------QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE 982
Query: 1035 SRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA-------- 1086
S ++++ L++ E E S+ Q+ + +L D + L +T
Sbjct: 983 REYGSCSHHYQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 1039
Query: 1087 ---SEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQR 1143
+ + + E +K + E + + + +K+ + E T LR
Sbjct: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT------LRSE 1093
Query: 1144 LQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-MPTT-- 1200
L+ L G +L ++ L + +R T+ AE L E L + +P T
Sbjct: 1094 LE-LTLG--KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1150
Query: 1201 -LEGAEAAIKK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINSDRIQEKVDS 1252
LE +A++KK E T DA +++ E G RL + ++ +R +E+V
Sbjct: 1151 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1210
Query: 1253 IDDRHRKNRETASELLMRLKD-NRDLQKFLQDCQELSLWINE---KMLTAQDMSYDEARN 1308
+ +R + L+ R L+ + + L W+ + + Q M +++
Sbjct: 1211 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1270
Query: 1309 LHSKWLKHQAFMAELASN-----------KEWLDKIEKEGMQLISEKPETEAVVKEKLTG 1357
+ + + QA + E+ + K++++ I+ +QL++ K + E V
Sbjct: 1271 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP--AK 1328
Query: 1358 LHKMWEVLESTTQTKAQ-RLFDANKAELFTQSCADLDKWLHGLE-----SQIQSDDYGKD 1411
K+ ES Q R + L +Q + + L +E ++ Q + +
Sbjct: 1329 KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER 1388
Query: 1412 LTSVNILLKKQQML-------ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQ 1464
L V L+KQ+ L + Q E KE+++ + Q + + +E + D KR ++Q
Sbjct: 1389 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKR-SIQ 1446
Query: 1465 TKFMELLEPLNERKHNLLASKEIHQFNR-DVEDEILWVGERMPLATSTDHG---HNLQTV 1520
+ +L + E + +R +E+EI V ++ AT G LQ +
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE-ATERQRGGAEGELQAL 1505
Query: 1521 QLLIKKNQTLQKEIQGHQPR----IDDIFERSQNIVTDSSS---LSAEAIRQRLADLKQL 1573
+ ++ + +++ Q R + D +R + + +S AEA R++ L+ L
Sbjct: 1506 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1565
Query: 1574 WGLLI--EETEKRHRRLE-EAHRAQQYYFDAAE--AEAWMSEQ-----ELYMMSEEKAKD 1623
L + EE E+R R+ E E R Q + A+ AEA + + E E ++
Sbjct: 1566 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1625
Query: 1624 EQSAVSMLKK---------------HQILEQAVEDY-------------AETVHQLSKTS 1655
E AV+ L++ + E+ +E + AE V Q +
Sbjct: 1626 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1685
Query: 1656 RALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIA 1715
+A E+ER + R+ K ++ ++LAE+ +L+++ +L + + ++ A
Sbjct: 1686 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ---ELEKQRQLAEGTAQ----QRLAA 1738
Query: 1716 EREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLAD-----ELINSGH 1770
E+E++ E Q + +L+E R+ Q+R + LA E++ +
Sbjct: 1739 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1798
Query: 1771 SDA-----ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQ-DK 1824
+ A +T + K L EL + ++ A + E + A+E R + +
Sbjct: 1799 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858
Query: 1825 HKKLPEELGRDQNTVETLQRMHTTFE---HDIQALGTQVRQLQEDAA----RLQAAYAGD 1877
+ L E+L + R+ T E + +A ++R+L ED A RL+ A
Sbjct: 1859 ERVLAEKLA----AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1914
Query: 1878 KAD------DIQKRENEVLEAWKSLL-DACESRR------VRLVDTGDKFRFFSMVRDLM 1924
KAD ++K + LE K L+ D RR + L + +K +L
Sbjct: 1915 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1974
Query: 1925 LWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL-----LA 1979
L IR A++ R EL + + AE + R ++ KSL A
Sbjct: 1975 LGR---IRS-NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAA 2028
Query: 1980 RKHYASEEIKEKLLQLTEKRKEMIDKWE-DRWEWLRLILEVHQFSRDA-SVAEAWLLGQE 2037
R+ A+ E E+L E+ + + ++ E + L+L E Q A A A+ + Q+
Sbjct: 2029 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2088
Query: 2038 PYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERK 2097
+ + Q +++L EA ++A +E ER E + RRQ EE ER
Sbjct: 2089 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER----EAAQSRRQVEEAERL 2144
Query: 2098 RRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDT---------- 2147
++ S E + +A++ + + EQ + AEQ + R + D
Sbjct: 2145 KQ--SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2202
Query: 2148 ------SEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQE---TPSA 2198
+++ T R +E+ + + + A AA ++ +E +
Sbjct: 2203 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2262
Query: 2199 QMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTA---------ASGIPY 2249
QME K EA N+ R N + + + A+ A A+ +
Sbjct: 2263 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2322
Query: 2250 HSEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKD-DEEMNTWIQAISSAISS 2308
+E ++ + A+ E L K + RL E L Q K+ +E +Q ++
Sbjct: 2323 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2382
Query: 2309 DKHEVSASTQSTPASSRAQTLPTS 2332
E + Q T + R + L S
Sbjct: 2383 QLAEETQGFQRTLEAERQRQLEMS 2406
Score = 103 bits (257), Expect = 2e-21
Identities = 324/1635 (19%), Positives = 647/1635 (39%), Gaps = 194/1635 (11%)
Query: 677 LSKHRAFEDEMSGRSGHFEQAIKEGEDMIA--EEHFGSEKIRERIIYIREQWANLEQLSA 734
+++ + + E+ G + E E ++A E + +R + + + LSA
Sbjct: 1050 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1109
Query: 735 IRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEY-STQSLVKKHKDVAEEI 793
I ++L+ SL+ + A+++ + LK + E +T++ +KK + AE
Sbjct: 1110 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA- 1168
Query: 794 ANYRPTLDTLHEQ-------ASALPQEHAESPDV-----RGRLSGIEERYKEVAELTRLR 841
+PT D L ++ L Q H E DV R R++ + ER++ V T +R
Sbjct: 1169 --QQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERWRERVAQLLERWQAVLAQTDVR 1225
Query: 842 KQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPE 897
++ L+ + + E AD W+ + + +Q L D + ++ + ++L E
Sbjct: 1226 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-LADSQAVREQLRQEQALLEE 1284
Query: 898 MNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRE--LVDRKKDALLSAL 955
+ +V + A+Q +++ E ++ + +L S ++ + + + +
Sbjct: 1285 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1344
Query: 956 SIQNYHLECNETKS----WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 1011
++ ++ E S +I E + +E + L A Q++ ER L +EA
Sbjct: 1345 DLRTHYSELTTLTSQYIKFISETLRRMEEEERL--------AEQQRAEERER-LAEVEAA 1395
Query: 1012 LSDLQKEAE---KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFL 1068
L ++ AE + +++ +A+ + R+ E EE + ++ S+ E +LQQ L
Sbjct: 1396 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE--ELQQ-L 1452
Query: 1069 RDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV 1128
R + + Q A E + Q E + + E + Q +R E
Sbjct: 1453 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1512
Query: 1129 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQ 1188
+ AQ R R Q D E + + L S+ A + R+ ++A L +
Sbjct: 1513 EAQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEAEAAREKQRALQAL--E 1566
Query: 1189 EYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQE 1248
E L E L AE +++ ++ + A +++ R ++ +R
Sbjct: 1567 ELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1621
Query: 1249 KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-ELSLWINEKMLTAQDMSYDEAR 1307
S+ + H + E R + + ++ ++ + EL W + +EA
Sbjct: 1622 ---SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW---------QLKANEAL 1669
Query: 1308 NLH--SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTG--LHKMWE 1363
L ++ + Q +A+ + K+ K E E K E +AV + +L L K +
Sbjct: 1670 RLRLQAEEVAQQKSLAQAEAEKQ---KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1726
Query: 1364 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1423
+ E T Q QRL A + EL A+ ++ + Q+ ++ + +K+Q
Sbjct: 1727 LAEGTAQ---QRL--AAEQELIRLR-AETEQGEQ--QRQLLEEELARLQREAAAATQKRQ 1778
Query: 1424 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT-KFMELLEPLN------- 1475
LE ++ + E+E L + +E +ST E +RL + +F EL E
Sbjct: 1779 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1838
Query: 1476 --ERKHNLL---ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL 1530
+R+ L A+++ + R + +++ +GE L T + + +K+ +
Sbjct: 1839 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---------IALKEKEAE 1889
Query: 1531 QKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL-------LIEETEK 1583
+ ++ + D+ F+R + + + ++ I +RLA L++ L+E+T +
Sbjct: 1890 NERLR--RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1945
Query: 1584 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-----EQSAVSMLKKHQILE 1638
+ R++EE A + F+ A A E EL + A+D EQ+ + ++ Q+
Sbjct: 1946 QRRQVEEEILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAARQRQL-- 2002
Query: 1639 QAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERH 1698
A E+ + ++L A+ +R + + +V++L A +++ R E
Sbjct: 2003 -AAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESA 2060
Query: 1699 RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTV 1758
R QL +E E+ + Q+ + ++ + R + +
Sbjct: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE- 2119
Query: 1759 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA---- 1814
A+E +AA + E R Q AA+ +L K
Sbjct: 2120 ---AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2176
Query: 1815 ----------KEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQ 1864
K+ +KHKK E+ R + VE + TT ++ Q L
Sbjct: 2177 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE---QELTTLRLQLEETDHQKNLLD 2233
Query: 1865 EDAARL--QAAYAGDKADDIQKR------ENEVLEAWKSLLDACESRRVRLVDTGDKFRF 1916
E+ RL +A A + +++ + E L K+ ++A E+R + L D + RF
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRF 2292
Query: 1917 FSMVRDLMLWM-EDVIR-QIEAQE--KPRDVSSVELLMNN---HQGIKAEIDARNDSFTT 1969
+ M + E+ R + AQE + R ++ +L + +K ++ A ++ T
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA--T 2350
Query: 1970 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2029
++ LL ++ E +E+ +L E +++M + + + + LE + + A
Sbjct: 2351 RLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2407
Query: 2030 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLEVR 2088
EA L SR ++ ++ ++ K+ E EK T + E++T ++ LE++
Sbjct: 2408 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQ 2464
Query: 2089 RQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD-- 2146
RQQ + + +R E ++ E E QQ +K Q+ + Q + ET
Sbjct: 2465 RQQSDHDAER---LREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLLQETQALQ 2519
Query: 2147 ---TSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPS------ 2197
SE + +R +E + + D AK AQ R Q+
Sbjct: 2520 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK----AQQLREEQQRQQQQMEQERQRL 2575
Query: 2198 -AQMEGFLNRKHEWE 2211
A ME R+HE E
Sbjct: 2576 VASMEEARRRQHEAE 2590
Score = 100 bits (250), Expect = 1e-20
Identities = 306/1580 (19%), Positives = 623/1580 (39%), Gaps = 215/1580 (13%)
Query: 713 EKIRERIIYIREQWANLEQLSAIRKKRLEEASL-LHQFQADADDIDAWMLDI-------- 763
E+ RER+ + E+W + + +R++ LE+ L ++ AD + AW+ D
Sbjct: 1202 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1261
Query: 764 -LKIVSSSDVGHDEYSTQSL---VKKHKDVAEE-----------IANYRPTLDTLHEQAS 808
+ + S V Q+L +++H + EE I +Y L T Q
Sbjct: 1262 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1321
Query: 809 ALPQEHAESPDVRGRLSGIEERYKEV----AELTRLRKQALQDTLALYKMFSEADACELW 864
+ A+ P V+ + + Y ++ +ELT L Q + K SE L
Sbjct: 1322 PVASP-AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI-------KFISET----LR 1369
Query: 865 IDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS-- 922
E+E+ L Q E+ E L ++ E A A + A++L
Sbjct: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429
Query: 923 ---EKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIE 979
E + AQQ K + + + + + + +A + A + Q E + + I E+ +V+
Sbjct: 1430 RREEAAVDAQQQKRSIQ--EELQQLRQSSEAEIQAKARQAEAAERSRLR--IEEEIRVVR 1485
Query: 980 STQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL-------QKEAEKLESEHPDQAQA 1032
+ A +R+ G E +L A+ A+ + Q+EAE+L + D++Q
Sbjct: 1486 LQLE---------ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536
Query: 1033 -------ILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLD-----DFQSWLSR 1080
+ SR+ ++ E + L+ E +A + ++ LR + Q L
Sbjct: 1537 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1596
Query: 1081 TQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFL 1140
Q + +E + AEK +++ E ++R+ E Q Q +A+
Sbjct: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEE----HVAVAQLREEAERRAQQQAEAE---- 1648
Query: 1141 RQRLQALDTGWNELHKMWENRQN------LLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH 1194
+A + EL + W+ + N L ++ A Q+ L QAEA +E A
Sbjct: 1649 ----RAREEAERELER-WQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQKEE---AE 1697
Query: 1195 TEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSID 1254
E + E A++++E + + +++ A +RL ++ + R +
Sbjct: 1698 REARRRGKAEEQAVRQRE--LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET------ 1749
Query: 1255 DRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWIN------EKMLTAQDMSYDEARN 1308
++ + R+ E L RL+ R+ Q QEL + E +L ++ + +E+R+
Sbjct: 1750 EQGEQQRQLLEEELARLQ--REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1807
Query: 1309 LHSKW---LKHQAF----MAELASNKEWLDKIEKEGMQLISE-----KPETEAVVKEKLT 1356
K L+ +A +AE A+ L + K QL E + E E V+ EKL
Sbjct: 1808 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867
Query: 1357 GLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVN 1416
+ + + +T+A+ +AE D+ + Q+ + D+
Sbjct: 1868 AIGEATRL-----KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1922
Query: 1417 ILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNE 1476
L+K ++++E +K +E+ Q + + +E + K + + L +
Sbjct: 1923 AQLRKAS--DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1980
Query: 1477 RKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQG 1536
+ L SKE + + ++ ER +L + ++ + +E++
Sbjct: 1981 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2040
Query: 1537 HQPRIDD---IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHR 1593
+ ++++ + ER++ L+ EA ++RL ++ +++ E+ L++ +
Sbjct: 2041 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE---LQQTLQ 2097
Query: 1594 AQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVS---MLKKHQILEQAVEDYAETVHQ 1650
+Q D EA + + E + + E+ A +++ + L+Q+ E+ A+ Q
Sbjct: 2098 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2157
Query: 1651 LSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLF--QLNREVD 1708
+ L E+E+ + R+++ ++ K A+ E+H+ F Q R+
Sbjct: 2158 AQAAAEKL----RKEAEQEAARRAQAEQAALRQKQAADAEM----EKHKKFAEQTLRQKA 2209
Query: 1709 DLEQWIA--EREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDT---VNHLAD 1763
+EQ + ++ H+ E + L+ E AR + +E + L+
Sbjct: 2210 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2269
Query: 1764 ELINSGHSDAATIAEWKDG----LNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFG 1819
+ A I KD L E + ++ + ++ A+ E + A+E
Sbjct: 2270 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2329
Query: 1820 RIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKA 1879
+ + +K+ +E ++ +Q T + + + L Q QE A RLQ DK
Sbjct: 2330 QQRALAEKMLKE------KMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQE----DKE 2378
Query: 1880 DDIQKRENEVLEAWKSLLDACESRRVRLVDTGD--KFRFFSMVRDLMLWMEDVIR-QIEA 1936
Q+ E + ++ L+A R++ + + K R M R ED R + +A
Sbjct: 2379 QMAQQLAEET-QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2437
Query: 1937 QEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLT 1996
+E + EL + ++ + + + +E ++E + +L
Sbjct: 2438 EEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------QSDHDAERLREAIAEL- 2482
Query: 1997 EKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLI 2056
E+ KE K + + L+L E Q + + + Q+ +LS E + L+
Sbjct: 2483 EREKE---KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---------EKDSLL 2530
Query: 2057 KRHEAFEKSAATWDERFS-ALERLTTLELLEVRRQQE-EEERKRRPPSPEPSTKVSEEAE 2114
+R E+ A ++ F + + L + R+QQ+ E+ER+R S E + + EAE
Sbjct: 2531 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2590
Query: 2115 -----SQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPS 2169
Q++ + ++ Q L AE+ + R+ E + E + A + +S + +
Sbjct: 2591 EGVRRKQEELQQLEQQRRQQEELLAEE-NQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2649
Query: 2170 PTSDRKAKTALPAQSAATLP 2189
+ + AL +A P
Sbjct: 2650 TKTLPNGRDALDGPAAEAEP 2669
Score = 100 bits (249), Expect = 2e-20
Identities = 307/1564 (19%), Positives = 623/1564 (39%), Gaps = 209/1564 (13%)
Query: 384 REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLAR--RFDRKAA-MRETWLSE 440
R G+ ++ + ER+ + + L +RQ +LEQL R R+ R++A WL +
Sbjct: 1193 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1252
Query: 441 NQRLVSQDNFG--FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKR 498
+R Q D AV ++ +A+ +I + E+V+ A++
Sbjct: 1253 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY---------- 1302
Query: 499 ITARKDNVIRLWEY--LLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 556
I A KD ++L Y LE + + ++ ++ G + + QE + + E+ L+ Y
Sbjct: 1303 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL--TTLTSQY 1360
Query: 557 GKHLL-GVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAH 615
K + + + ++ L E + ER+ V A+ +K E + Q R+
Sbjct: 1361 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1420
Query: 616 MEFCYQELCQ-------LAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGK 668
+ +E+ + ++R+ EE ++L + AE + R+ E S +
Sbjct: 1421 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SEAEIQAKARQAEAAERSRLRIE 1478
Query: 669 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG---SEKIRERI--IYIR 723
+ V+RL + A E + G G + E+ A++ +E++R ++ R
Sbjct: 1479 EEIRVVRL--QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536
Query: 724 EQWANLEQLSAIR------KKRLEEASLLHQFQADADDIDAWM----LDILKIVSSSDVG 773
++ A +E S ++ +++ L + + A++ + + ++ + V +
Sbjct: 1537 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1596
Query: 774 HDEYSTQSLVKKHKDVAEEIANYRPTLDTLH-------EQASALPQEHAESPDVRGRLSG 826
+ L K AE+ A +L H E+A Q+ AE+ R
Sbjct: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656
Query: 827 IEERYK-EVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 885
ER++ + E RLR QA + +A K ++A+A + +KE+ + K E+
Sbjct: 1657 ELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQA 1710
Query: 886 VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 945
V Q E E Q + ++A + +E E QQ +L EL
Sbjct: 1711 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELAR 1765
Query: 946 RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL-----TG 1000
+++A +A + + LE K +R + +V+ +++ + + + + K G
Sbjct: 1766 LQREA--AAATQKRQELEAELAK--VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1821
Query: 1001 MERDLVAIEAKLSDLQKEA--------EKLESEHPDQAQAILSRLAEISDVWE---EMKT 1049
R+L A+L L +EA E + + + + +LA I + E +
Sbjct: 1822 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1881
Query: 1050 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1109
LK +EA E +L++ D + FQ Q A D+ L + K ++
Sbjct: 1882 ALKEKEA---ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRK--ASDSELER 1935
Query: 1110 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH-KMWENRQNLLSQS 1168
+ E+ ++ R Q + + + L+ + G EL ++ R N
Sbjct: 1936 QKGLVEDTLRQRR---------QVEEEILALKASFEKAAAGKAELELELGRIRSNA---- 1982
Query: 1169 HAYQQFLRDTKQAEAFLNNQEYVLAHTE---------MPTTLEGAEAAIKKQEDFMTTMD 1219
+ LR +QAE Q + A E + +L E A ++++ + +
Sbjct: 1983 ---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV- 2038
Query: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1279
E++ A VE RRL S R + + + E A ++ K+ ++LQ+
Sbjct: 2039 ---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQ 2094
Query: 1280 FLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ 1339
LQ Q + +++ + + A ++ + A+ E +++++ +
Sbjct: 2095 TLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2150
Query: 1340 LISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH-- 1397
+ + +A E L + +A R A +A L + AD + H
Sbjct: 2151 QAQARAQAQAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2199
Query: 1398 -GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA-QALSQEGKSTDE 1455
++ Q ++LT++ + L++ ++Q + +E++ L+++A +A Q + +E
Sbjct: 2200 FAEQTLRQKAQVEQELTTLRLQLEE---TDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2256
Query: 1456 VDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH 1515
+ S R VQ + + L+ E ++ L ++ R +++E E+M + +
Sbjct: 2257 LFSVR--VQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMK-QVAEEAAR 2309
Query: 1516 NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA------------- 1562
Q + Q ++++ + + + + V +++ L AEA
Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2369
Query: 1563 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1622
R+ D +Q+ L EET+ R L EA R +Q AEA + + MS +A+
Sbjct: 2370 ARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQL---EMSAEAERLKLRVAEMSRAQAR 2425
Query: 1623 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVD--KLY 1680
E+ A Q + E+ E +H+ ++ V + ++ I +QS D +L
Sbjct: 2426 AEEDA-------QRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQSDHDAERLR 2476
Query: 1681 AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDY--EHVTMLQ- 1737
+ +L E+ KL + +L QL E Q + + +++ + L Q + E ++LQ
Sbjct: 2477 EAIAELEREKE-KLQQEAKLLQLKSEE---MQTVQQEQLLQETQALQQSFLSEKDSLLQR 2532
Query: 1738 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1797
ERF I QE+ DE +A+ + E ++ R
Sbjct: 2533 ERF---------IEQEKAKLEQLFQDE-----------VAKAQQLREEQQRQQQQMEQER 2572
Query: 1798 TQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALG 1857
+++A+ E + H+A+E R Q++ ++L ++ + + E L + +Q L
Sbjct: 2573 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE---ELLAEENQRLREQLQLLE 2629
Query: 1858 TQVR 1861
Q R
Sbjct: 2630 EQHR 2633
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 402 bits (1034), Expect = e-111
Identities = 576/2480 (23%), Positives = 1023/2480 (41%), Gaps = 325/2480 (13%)
Query: 45 IKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPT 104
+K + DER+ VQKKTFTKWVN HL + I+DLY DLRDG LI LLEVLSG+ LP+
Sbjct: 1 MKIVPDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE- 59
Query: 105 KGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISV 164
KGRMR H L+NV AL +L+ ++V L N+ + DI DGN +LTLGLIWTIIL FQI DI V
Sbjct: 60 KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQV 119
Query: 165 ETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDK 224
+ E +AK+ LLLW Q GY + NFT+SWRDG FNA+IH+H+P LID +K
Sbjct: 120 SGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNK 177
Query: 225 LKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALA 284
+ + NL AF++AE+ LG+T+LLDPED+ V PDEKSIITYV + Y ++ +
Sbjct: 178 VYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ 237
Query: 285 VEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAF 344
+G R A E + ++Y L LL+W+ R+F +S ++ F
Sbjct: 238 -DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQF 289
Query: 345 NTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEH 404
++ +E P K +K + + +++ ++A KV G D+ K W +L A
Sbjct: 290 LKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAIL 346
Query: 405 ERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKH 464
ERE LR+E R E L+++ + +A + E L++ L+ D L A ++
Sbjct: 347 EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRA 403
Query: 465 EAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRL 524
+E D+ + ++ + + L+ + +++ R V RL E L+ + RL
Sbjct: 404 GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHERLVAIRTEYNLRL 460
Query: 525 EMNLG----------LQKIFQE-------MLYIMD---WMDEMKVLVLSQDYGKHLLGVE 564
+ + LQ + + + Y+ D W++E + V ++G L VE
Sbjct: 461 KAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVE 520
Query: 565 DLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELC 624
L H + + + A ++ +D P RD + ++ Y +L
Sbjct: 521 AQLGSHRGLH-------QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLL 573
Query: 625 QLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFE 684
+ARL L F +E W+ EKE+ D+ T++ + A
Sbjct: 574 N---SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 630
Query: 685 DEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEAS 744
E+ + ++ G+ ++ E+H + ++ QW+ + QL + L+E +
Sbjct: 631 RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENA 690
Query: 745 LLHQFQADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLD 801
QF +D + + + + L+ S D + L++ +D E++ Y+ L
Sbjct: 691 AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 750
Query: 802 TLHEQASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQALQDTLALYKMFSEA 858
L ++A A+ Q P +RGRL + YK+V E+T +
Sbjct: 751 GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT----------------VHKG 793
Query: 859 DACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHS 918
D C+L P + +V+ E + + V NQ A++ +
Sbjct: 794 DECQL------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLVPPPNQEAQEAV-- 837
Query: 919 GHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVI 978
++AQ L T W Q VD K S L+ Q+ + +SW + +
Sbjct: 838 -----TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQLIRSWSLATFRTL 885
Query: 979 ESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLA 1038
+ + + L ++E ++++ P+
Sbjct: 886 KPEE------------------QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG 927
Query: 1039 EISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA-----------S 1087
S ++++ L++ E E S+ Q+ + +L D + L +T +
Sbjct: 928 SCSHHYQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA 984
Query: 1088 EDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQAL 1147
+ + E +K + E + + + +K+ + E T LR L+ L
Sbjct: 985 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT------LRSELE-L 1037
Query: 1148 DTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-MPTT---LEG 1203
G +L ++ L + +R T+ AE L E L + +P T LE
Sbjct: 1038 TLG--KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1095
Query: 1204 AEAAIKK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINSDRIQEKVDSIDDR 1256
+A++KK E T DA +++ E G RL + ++ +R +E+V + +R
Sbjct: 1096 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1155
Query: 1257 HRKNRETASELLMRLKD-NRDLQKFLQDCQELSLWINE---KMLTAQDMSYDEARNLHSK 1312
+ L+ R L+ + + L W+ + + Q M +++ + +
Sbjct: 1156 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1215
Query: 1313 WLKHQAFMAELASN-----------KEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKM 1361
+ QA + E+ + K++++ I+ +QL++ K + E V K+
Sbjct: 1216 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP--AKKPKV 1273
Query: 1362 WEVLESTTQTKAQ-RLFDANKAELFTQSCADLDKWLHGLE-----SQIQSDDYGKDLTSV 1415
ES Q R + L +Q + + L +E ++ Q + + L V
Sbjct: 1274 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1333
Query: 1416 NILLKKQQML-------ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFM 1468
L+KQ+ L + Q E KE+++ + Q + + +E + D KR ++Q +
Sbjct: 1334 EAALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKR-SIQEELQ 1391
Query: 1469 ELLEPLNERKHNLLASKEIHQFNR-DVEDEILWVGERMPLATSTDHG---HNLQTVQLLI 1524
+L + E + +R +E+EI V ++ AT G LQ ++
Sbjct: 1392 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE-ATERQRGGAEGELQALRARA 1450
Query: 1525 KKNQTLQKEIQGHQPR----IDDIFERSQNIVTDSSS---LSAEAIRQRLADLKQLWGLL 1577
++ + +++ Q R + D +R + + +S AEA R++ L+ L L
Sbjct: 1451 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1510
Query: 1578 I--EETEKRHRRLE-EAHRAQQYYFDAAE--AEAWMSEQ-----ELYMMSEEKAKDEQSA 1627
+ EE E+R R+ E E R Q + A+ AEA + + E E ++E A
Sbjct: 1511 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1570
Query: 1628 VSMLKK---------------HQILEQAVEDY-------------AETVHQLSKTSRALV 1659
V+ L++ + E+ +E + AE V Q ++A
Sbjct: 1571 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1630
Query: 1660 ADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREV 1719
E+ER + R+ K ++ ++LAE+ +L+++ +L + + ++ AE+E+
Sbjct: 1631 EKQKEEAEREARRRGKAEEQAVRQRELAEQ---ELEKQRQLAEGTAQ----QRLAAEQEL 1683
Query: 1720 VAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLAD-----ELINSGHSDA- 1773
+ E Q + +L+E R+ Q+R + LA E++ + + A
Sbjct: 1684 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1743
Query: 1774 ----ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQ-DKHKKL 1828
+T + K L EL + ++ A + E + A+E R + + + L
Sbjct: 1744 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1803
Query: 1829 PEELGRDQNTVETLQRMHTTFE---HDIQALGTQVRQLQEDAA----RLQAAYAGDKAD- 1880
E+L + R+ T E + +A ++R+L ED A RL+ A KAD
Sbjct: 1804 AEKLA----AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1859
Query: 1881 -----DIQKRENEVLEAWKSLL-DACESRR------VRLVDTGDKFRFFSMVRDLMLWME 1928
++K + LE K L+ D RR + L + +K +L L
Sbjct: 1860 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR- 1918
Query: 1929 DVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL-----LARKHY 1983
IR A++ R EL + + AE + R ++ KSL AR+
Sbjct: 1919 --IRS-NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAARQRK 1973
Query: 1984 ASEEIKEKLLQLTEKRKEMIDKWE-DRWEWLRLILEVHQFSRDA-SVAEAWLLGQEPYLS 2041
A+ E E+L E+ + + ++ E + L+L E Q A A A+ + Q+
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2033
Query: 2042 SREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPP 2101
+ + Q +++L EA ++A +E ER E + RRQ EE ER ++
Sbjct: 2034 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER----EAAQSRRQVEEAERLKQ-- 2087
Query: 2102 SPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDT-------------- 2147
S E + +A++ + + EQ + AEQ + R + D
Sbjct: 2088 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2147
Query: 2148 --SEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQE---TPSAQMEG 2202
+++ T R +E+ + + + A AA ++ +E + QME
Sbjct: 2148 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207
Query: 2203 FLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTA---------ASGIPYHSEV 2253
K EA N+ R N + + + A+ A A+ + +E
Sbjct: 2208 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2267
Query: 2254 PVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKD-DEEMNTWIQAISSAISSDKHE 2312
++ + A+ E L K + RL E L Q K+ +E +Q ++ E
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2327
Query: 2313 VSASTQSTPASSRAQTLPTS 2332
+ Q T + R + L S
Sbjct: 2328 ETQGFQRTLEAERQRQLEMS 2347
Score = 103 bits (257), Expect = 2e-21
Identities = 324/1635 (19%), Positives = 647/1635 (39%), Gaps = 194/1635 (11%)
Query: 677 LSKHRAFEDEMSGRSGHFEQAIKEGEDMIA--EEHFGSEKIRERIIYIREQWANLEQLSA 734
+++ + + E+ G + E E ++A E + +R + + + LSA
Sbjct: 991 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1050
Query: 735 IRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEY-STQSLVKKHKDVAEEI 793
I ++L+ SL+ + A+++ + LK + E +T++ +KK + AE
Sbjct: 1051 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA- 1109
Query: 794 ANYRPTLDTLHEQ-------ASALPQEHAESPDV-----RGRLSGIEERYKEVAELTRLR 841
+PT D L ++ L Q H E DV R R++ + ER++ V T +R
Sbjct: 1110 --QQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERWRERVAQLLERWQAVLAQTDVR 1166
Query: 842 KQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPE 897
++ L+ + + E AD W+ + + +Q L D + ++ + ++L E
Sbjct: 1167 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-LADSQAVREQLRQEQALLEE 1225
Query: 898 MNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRE--LVDRKKDALLSAL 955
+ +V + A+Q +++ E ++ + +L S ++ + + + +
Sbjct: 1226 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1285
Query: 956 SIQNYHLECNETKS----WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 1011
++ ++ E S +I E + +E + L A Q++ ER L +EA
Sbjct: 1286 DLRTHYSELTTLTSQYIKFISETLRRMEEEERL--------AEQQRAEERER-LAEVEAA 1336
Query: 1012 LSDLQKEAE---KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFL 1068
L ++ AE + +++ +A+ + R+ E EE + ++ S+ E +LQQ L
Sbjct: 1337 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE--ELQQ-L 1393
Query: 1069 RDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV 1128
R + + Q A E + Q E + + E + Q +R E
Sbjct: 1394 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1453
Query: 1129 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQ 1188
+ AQ R R Q D E + + L S+ A + R+ ++A L +
Sbjct: 1454 EAQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEAEAAREKQRALQAL--E 1507
Query: 1189 EYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQE 1248
E L E L AE +++ ++ + A +++ R ++ +R
Sbjct: 1508 ELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1562
Query: 1249 KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-ELSLWINEKMLTAQDMSYDEAR 1307
S+ + H + E R + + ++ ++ + EL W + +EA
Sbjct: 1563 ---SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW---------QLKANEAL 1610
Query: 1308 NLH--SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTG--LHKMWE 1363
L ++ + Q +A+ + K+ K E E K E +AV + +L L K +
Sbjct: 1611 RLRLQAEEVAQQKSLAQAEAEKQ---KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1667
Query: 1364 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1423
+ E T Q QRL A + EL A+ ++ + Q+ ++ + +K+Q
Sbjct: 1668 LAEGTAQ---QRL--AAEQELIRLR-AETEQGEQ--QRQLLEEELARLQREAAAATQKRQ 1719
Query: 1424 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT-KFMELLEPLN------- 1475
LE ++ + E+E L + +E +ST E +RL + +F EL E
Sbjct: 1720 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1779
Query: 1476 --ERKHNLL---ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL 1530
+R+ L A+++ + R + +++ +GE L T + + +K+ +
Sbjct: 1780 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---------IALKEKEAE 1830
Query: 1531 QKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL-------LIEETEK 1583
+ ++ + D+ F+R + + + ++ I +RLA L++ L+E+T +
Sbjct: 1831 NERLR--RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1886
Query: 1584 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-----EQSAVSMLKKHQILE 1638
+ R++EE A + F+ A A E EL + A+D EQ+ + ++ Q+
Sbjct: 1887 QRRQVEEEILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAARQRQL-- 1943
Query: 1639 QAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERH 1698
A E+ + ++L A+ +R + + +V++L A +++ R E
Sbjct: 1944 -AAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESA 2001
Query: 1699 RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTV 1758
R QL +E E+ + Q+ + ++ + R + +
Sbjct: 2002 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE- 2060
Query: 1759 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA---- 1814
A+E +AA + E R Q AA+ +L K
Sbjct: 2061 ---AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2117
Query: 1815 ----------KEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQ 1864
K+ +KHKK E+ R + VE + TT ++ Q L
Sbjct: 2118 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE---QELTTLRLQLEETDHQKNLLD 2174
Query: 1865 EDAARL--QAAYAGDKADDIQKR------ENEVLEAWKSLLDACESRRVRLVDTGDKFRF 1916
E+ RL +A A + +++ + E L K+ ++A E+R + L D + RF
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRF 2233
Query: 1917 FSMVRDLMLWM-EDVIR-QIEAQE--KPRDVSSVELLMNN---HQGIKAEIDARNDSFTT 1969
+ M + E+ R + AQE + R ++ +L + +K ++ A ++ T
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA--T 2291
Query: 1970 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2029
++ LL ++ E +E+ +L E +++M + + + + LE + + A
Sbjct: 2292 RLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2348
Query: 2030 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLEVR 2088
EA L SR ++ ++ ++ K+ E EK T + E++T ++ LE++
Sbjct: 2349 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQ 2405
Query: 2089 RQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD-- 2146
RQQ + + +R E ++ E E QQ +K Q+ + Q + ET
Sbjct: 2406 RQQSDHDAER---LREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLLQETQALQ 2460
Query: 2147 ---TSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPS------ 2197
SE + +R +E + + D AK AQ R Q+
Sbjct: 2461 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK----AQQLREEQQRQQQQMEQERQRL 2516
Query: 2198 -AQMEGFLNRKHEWE 2211
A ME R+HE E
Sbjct: 2517 VASMEEARRRQHEAE 2531
Score = 100 bits (250), Expect = 1e-20
Identities = 306/1580 (19%), Positives = 623/1580 (39%), Gaps = 215/1580 (13%)
Query: 713 EKIRERIIYIREQWANLEQLSAIRKKRLEEASL-LHQFQADADDIDAWMLDI-------- 763
E+ RER+ + E+W + + +R++ LE+ L ++ AD + AW+ D
Sbjct: 1143 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1202
Query: 764 -LKIVSSSDVGHDEYSTQSL---VKKHKDVAEE-----------IANYRPTLDTLHEQAS 808
+ + S V Q+L +++H + EE I +Y L T Q
Sbjct: 1203 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1262
Query: 809 ALPQEHAESPDVRGRLSGIEERYKEV----AELTRLRKQALQDTLALYKMFSEADACELW 864
+ A+ P V+ + + Y ++ +ELT L Q + K SE L
Sbjct: 1263 PVASP-AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI-------KFISET----LR 1310
Query: 865 IDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS-- 922
E+E+ L Q E+ E L ++ E A A + A++L
Sbjct: 1311 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370
Query: 923 ---EKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIE 979
E + AQQ K + + + + + + +A + A + Q E + + I E+ +V+
Sbjct: 1371 RREEAAVDAQQQKRSIQ--EELQQLRQSSEAEIQAKARQAEAAERSRLR--IEEEIRVVR 1426
Query: 980 STQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL-------QKEAEKLESEHPDQAQA 1032
+ A +R+ G E +L A+ A+ + Q+EAE+L + D++Q
Sbjct: 1427 LQLE---------ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477
Query: 1033 -------ILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLD-----DFQSWLSR 1080
+ SR+ ++ E + L+ E +A + ++ LR + Q L
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1537
Query: 1081 TQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFL 1140
Q + +E + AEK +++ E ++R+ E Q Q +A+
Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEE----HVAVAQLREEAERRAQQQAEAE---- 1589
Query: 1141 RQRLQALDTGWNELHKMWENRQN------LLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH 1194
+A + EL + W+ + N L ++ A Q+ L QAEA +E A
Sbjct: 1590 ----RAREEAERELER-WQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQKEE---AE 1638
Query: 1195 TEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSID 1254
E + E A++++E + + +++ A +RL ++ + R +
Sbjct: 1639 REARRRGKAEEQAVRQRE--LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET------ 1690
Query: 1255 DRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWIN------EKMLTAQDMSYDEARN 1308
++ + R+ E L RL+ R+ Q QEL + E +L ++ + +E+R+
Sbjct: 1691 EQGEQQRQLLEEELARLQ--REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1748
Query: 1309 LHSKW---LKHQAF----MAELASNKEWLDKIEKEGMQLISE-----KPETEAVVKEKLT 1356
K L+ +A +AE A+ L + K QL E + E E V+ EKL
Sbjct: 1749 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1808
Query: 1357 GLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVN 1416
+ + + +T+A+ +AE D+ + Q+ + D+
Sbjct: 1809 AIGEATRL-----KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1863
Query: 1417 ILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNE 1476
L+K ++++E +K +E+ Q + + +E + K + + L +
Sbjct: 1864 AQLRKAS--DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1921
Query: 1477 RKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQG 1536
+ L SKE + + ++ ER +L + ++ + +E++
Sbjct: 1922 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1981
Query: 1537 HQPRIDD---IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHR 1593
+ ++++ + ER++ L+ EA ++RL ++ +++ E+ L++ +
Sbjct: 1982 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE---LQQTLQ 2038
Query: 1594 AQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVS---MLKKHQILEQAVEDYAETVHQ 1650
+Q D EA + + E + + E+ A +++ + L+Q+ E+ A+ Q
Sbjct: 2039 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2098
Query: 1651 LSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLF--QLNREVD 1708
+ L E+E+ + R+++ ++ K A+ E+H+ F Q R+
Sbjct: 2099 AQAAAEKL----RKEAEQEAARRAQAEQAALRQKQAADAEM----EKHKKFAEQTLRQKA 2150
Query: 1709 DLEQWIA--EREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDT---VNHLAD 1763
+EQ + ++ H+ E + L+ E AR + +E + L+
Sbjct: 2151 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2210
Query: 1764 ELINSGHSDAATIAEWKDG----LNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFG 1819
+ A I KD L E + ++ + ++ A+ E + A+E
Sbjct: 2211 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2270
Query: 1820 RIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKA 1879
+ + +K+ +E ++ +Q T + + + L Q QE A RLQ DK
Sbjct: 2271 QQRALAEKMLKE------KMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQE----DKE 2319
Query: 1880 DDIQKRENEVLEAWKSLLDACESRRVRLVDTGD--KFRFFSMVRDLMLWMEDVIR-QIEA 1936
Q+ E + ++ L+A R++ + + K R M R ED R + +A
Sbjct: 2320 QMAQQLAEET-QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2378
Query: 1937 QEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLT 1996
+E + EL + ++ + + + +E ++E + +L
Sbjct: 2379 EEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------QSDHDAERLREAIAEL- 2423
Query: 1997 EKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLI 2056
E+ KE K + + L+L E Q + + + Q+ +LS E + L+
Sbjct: 2424 EREKE---KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---------EKDSLL 2471
Query: 2057 KRHEAFEKSAATWDERFS-ALERLTTLELLEVRRQQE-EEERKRRPPSPEPSTKVSEEAE 2114
+R E+ A ++ F + + L + R+QQ+ E+ER+R S E + + EAE
Sbjct: 2472 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2531
Query: 2115 -----SQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPS 2169
Q++ + ++ Q L AE+ + R+ E + E + A + +S + +
Sbjct: 2532 EGVRRKQEELQQLEQQRRQQEELLAEE-NQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2590
Query: 2170 PTSDRKAKTALPAQSAATLP 2189
+ + AL +A P
Sbjct: 2591 TKTLPNGRDALDGPAAEAEP 2610
Score = 100 bits (249), Expect = 2e-20
Identities = 307/1564 (19%), Positives = 623/1564 (39%), Gaps = 209/1564 (13%)
Query: 384 REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLAR--RFDRKAA-MRETWLSE 440
R G+ ++ + ER+ + + L +RQ +LEQL R R+ R++A WL +
Sbjct: 1134 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1193
Query: 441 NQRLVSQDNFG--FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKR 498
+R Q D AV ++ +A+ +I + E+V+ A++
Sbjct: 1194 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY---------- 1243
Query: 499 ITARKDNVIRLWEY--LLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 556
I A KD ++L Y LE + + ++ ++ G + + QE + + E+ L+ Y
Sbjct: 1244 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL--TTLTSQY 1301
Query: 557 GKHLL-GVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAH 615
K + + + ++ L E + ER+ V A+ +K E + Q R+
Sbjct: 1302 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1361
Query: 616 MEFCYQELCQ-------LAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGK 668
+ +E+ + ++R+ EE ++L + AE + R+ E S +
Sbjct: 1362 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SEAEIQAKARQAEAAERSRLRIE 1419
Query: 669 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG---SEKIRERI--IYIR 723
+ V+RL + A E + G G + E+ A++ +E++R ++ R
Sbjct: 1420 EEIRVVRL--QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477
Query: 724 EQWANLEQLSAIR------KKRLEEASLLHQFQADADDIDAWM----LDILKIVSSSDVG 773
++ A +E S ++ +++ L + + A++ + + ++ + V +
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1537
Query: 774 HDEYSTQSLVKKHKDVAEEIANYRPTLDTLH-------EQASALPQEHAESPDVRGRLSG 826
+ L K AE+ A +L H E+A Q+ AE+ R
Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1597
Query: 827 IEERYK-EVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 885
ER++ + E RLR QA + +A K ++A+A + +KE+ + K E+
Sbjct: 1598 ELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQA 1651
Query: 886 VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 945
V Q E E Q + ++A + +E E QQ +L EL
Sbjct: 1652 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELAR 1706
Query: 946 RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL-----TG 1000
+++A +A + + LE K +R + +V+ +++ + + + + K G
Sbjct: 1707 LQREA--AAATQKRQELEAELAK--VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1762
Query: 1001 MERDLVAIEAKLSDLQKEA--------EKLESEHPDQAQAILSRLAEISDVWE---EMKT 1049
R+L A+L L +EA E + + + + +LA I + E +
Sbjct: 1763 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1822
Query: 1050 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1109
LK +EA E +L++ D + FQ Q A D+ L + K ++
Sbjct: 1823 ALKEKEA---ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRK--ASDSELER 1876
Query: 1110 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH-KMWENRQNLLSQS 1168
+ E+ ++ R Q + + + L+ + G EL ++ R N
Sbjct: 1877 QKGLVEDTLRQRR---------QVEEEILALKASFEKAAAGKAELELELGRIRSNA---- 1923
Query: 1169 HAYQQFLRDTKQAEAFLNNQEYVLAHTE---------MPTTLEGAEAAIKKQEDFMTTMD 1219
+ LR +QAE Q + A E + +L E A ++++ + +
Sbjct: 1924 ---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV- 1979
Query: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1279
E++ A VE RRL S R + + + E A ++ K+ ++LQ+
Sbjct: 1980 ---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQ 2035
Query: 1280 FLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ 1339
LQ Q + +++ + + A ++ + A+ E +++++ +
Sbjct: 2036 TLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2091
Query: 1340 LISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH-- 1397
+ + +A E L + +A R A +A L + AD + H
Sbjct: 2092 QAQARAQAQAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2140
Query: 1398 -GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA-QALSQEGKSTDE 1455
++ Q ++LT++ + L++ ++Q + +E++ L+++A +A Q + +E
Sbjct: 2141 FAEQTLRQKAQVEQELTTLRLQLEE---TDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2197
Query: 1456 VDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH 1515
+ S R VQ + + L+ E ++ L ++ R +++E E+M + +
Sbjct: 2198 LFSVR--VQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMK-QVAEEAAR 2250
Query: 1516 NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA------------- 1562
Q + Q ++++ + + + + V +++ L AEA
Sbjct: 2251 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2310
Query: 1563 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1622
R+ D +Q+ L EET+ R L EA R +Q AEA + + MS +A+
Sbjct: 2311 ARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQL---EMSAEAERLKLRVAEMSRAQAR 2366
Query: 1623 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVD--KLY 1680
E+ A Q + E+ E +H+ ++ V + ++ I +QS D +L
Sbjct: 2367 AEEDA-------QRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQSDHDAERLR 2417
Query: 1681 AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDY--EHVTMLQ- 1737
+ +L E+ KL + +L QL E Q + + +++ + L Q + E ++LQ
Sbjct: 2418 EAIAELEREKE-KLQQEAKLLQLKSEE---MQTVQQEQLLQETQALQQSFLSEKDSLLQR 2473
Query: 1738 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1797
ERF I QE+ DE +A+ + E ++ R
Sbjct: 2474 ERF---------IEQEKAKLEQLFQDE-----------VAKAQQLREEQQRQQQQMEQER 2513
Query: 1798 TQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALG 1857
+++A+ E + H+A+E R Q++ ++L ++ + + E L + +Q L
Sbjct: 2514 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE---ELLAEENQRLREQLQLLE 2570
Query: 1858 TQVR 1861
Q R
Sbjct: 2571 EQHR 2574
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 401 bits (1031), Expect = e-111
Identities = 579/2493 (23%), Positives = 1027/2493 (41%), Gaps = 326/2493 (13%)
Query: 32 NENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKL 91
+E + +E R K DER+ VQKKTFTKWVN HL + I+DLY DLRDG LI L
Sbjct: 7 DEQDFIQAYEEVREK-YKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISL 65
Query: 92 LEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIW 151
LEVLSG+ LP+ KGRMR H L+NV AL +L+ ++V L N+ + DI DGN +LTLGLIW
Sbjct: 66 LEVLSGDSLPRE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIW 124
Query: 152 TIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNAL 211
TIIL FQI DI V + E +AK+ LLLW Q GY + NFT+SWRDG FNA+
Sbjct: 125 TIILHFQISDIQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAI 182
Query: 212 IHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVV 271
IH+H+P LID +K+ + NL AF++AE+ LG+T+LLDPED+ V PDEKSIITYV
Sbjct: 183 IHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVS 242
Query: 272 TYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFA 331
+ Y ++ + +G R A E + ++Y L LL+W+ R+F
Sbjct: 243 SLYDAMPRVPDVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 294
Query: 332 NSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISD 391
+S ++ F ++ +E P K +K + + +++ ++A KV G D
Sbjct: 295 SSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLD 351
Query: 392 INKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFG 451
+ K W +L A ERE LR+E R E L+++ + +A + E L++ L+ D
Sbjct: 352 VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD--- 408
Query: 452 FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWE 511
L A ++ +E D+ + ++ + + L+ + +++ R V RL E
Sbjct: 409 VRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHE 465
Query: 512 YLLELLRARRQRLEMNLG----------LQKIFQE-------MLYIMD---WMDEMKVLV 551
L+ + RL+ + LQ + + + Y+ D W++E + V
Sbjct: 466 RLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV 525
Query: 552 LSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRD 611
++G L VE L H + + + A ++ +D P RD
Sbjct: 526 DGAEWGVDLPSVEAQLGSHRGLH-------QSIEEFRAKIERARSDEGQLSPATRGAYRD 578
Query: 612 RVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLT 671
+ ++ Y +L +ARL L F +E W+ EKE+ D+ T
Sbjct: 579 CLGRLDLQYAKLLN---SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNT 635
Query: 672 SVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQ 731
++ + A E+ + ++ G+ ++ E+H + ++ QW+ + Q
Sbjct: 636 NMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQ 695
Query: 732 LSAIRKKRLEEASLLHQFQADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKD 788
L + L+E + QF +D + + + + L+ S D + L++ +D
Sbjct: 696 LCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQD 755
Query: 789 VAEEIANYRPTLDTLHEQASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQAL 845
E++ Y+ L L ++A A+ Q P +RGRL + YK+V E+T
Sbjct: 756 EKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT------- 807
Query: 846 QDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRV 905
+ D C+L P + +V+ E + + V
Sbjct: 808 ---------VHKGDECQL------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLV 844
Query: 906 AVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECN 965
NQ A++ + ++AQ L T W Q VD K S L+ Q+ +
Sbjct: 845 PPPNQEAQEAV-------TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQ 890
Query: 966 ETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESE 1025
+SW + ++ + + L ++E ++++
Sbjct: 891 LIRSWSLATFRTLKPEE------------------QRQALHSLELHYQAFLRDSQDAGGF 932
Query: 1026 HPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAI 1085
P+ S ++++ L++ E E S+ Q+ + +L D + L +T
Sbjct: 933 GPEDRLMAEREYGSCSHHYQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRT 989
Query: 1086 A-----------SEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTD 1134
+ + + E +K + E + + + +K+ + E T
Sbjct: 990 VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT- 1048
Query: 1135 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH 1194
LR L+ L G +L ++ L + +R T+ AE L E L
Sbjct: 1049 -----LRSELE-LTLG--KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1100
Query: 1195 TE-MPTT---LEGAEAAIKK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINS 1243
+ +P T LE +A++KK E T DA +++ E G RL + ++
Sbjct: 1101 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1160
Query: 1244 DRIQEKVDSIDDRHRKNRETASELLMRLKD-NRDLQKFLQDCQELSLWINE---KMLTAQ 1299
+R +E+V + +R + L+ R L+ + + L W+ + + Q
Sbjct: 1161 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1220
Query: 1300 DMSYDEARNLHSKWLKHQAFMAELASN-----------KEWLDKIEKEGMQLISEKPETE 1348
M +++ + + + QA + E+ + K++++ I+ +QL++ K + E
Sbjct: 1221 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1280
Query: 1349 AVVKEKLTGLHKMWEVLESTTQTKAQ-RLFDANKAELFTQSCADLDKWLHGLE-----SQ 1402
V K+ ES Q R + L +Q + + L +E ++
Sbjct: 1281 PVASP--AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1338
Query: 1403 IQSDDYGKDLTSVNILLKKQQML-------ENQMEVRKKEIEELQSQAQALSQEGKSTDE 1455
Q + + L V L+KQ+ L + Q E KE+++ + Q + + +E + D
Sbjct: 1339 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDA 1397
Query: 1456 VDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNR-DVEDEILWVGERMPLATSTDHG 1514
KR ++Q + +L + E + +R +E+EI V ++ AT G
Sbjct: 1398 QQQKR-SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE-ATERQRG 1455
Query: 1515 ---HNLQTVQLLIKKNQTLQKEIQGHQPR----IDDIFERSQNIVTDSSS---LSAEAIR 1564
LQ ++ ++ + +++ Q R + D +R + + +S AEA R
Sbjct: 1456 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1515
Query: 1565 QRLADLKQLWGLLI--EETEKRHRRLE-EAHRAQQYYFDAAE--AEAWMSEQ-----ELY 1614
++ L+ L L + EE E+R R+ E E R Q + A+ AEA + + E
Sbjct: 1516 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1575
Query: 1615 MMSEEKAKDEQSAVSMLKK---------------HQILEQAVEDY-------------AE 1646
E ++E AV+ L++ + E+ +E + AE
Sbjct: 1576 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1635
Query: 1647 TVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNRE 1706
V Q ++A E+ER + R+ K ++ ++LAE+ +L+++ +L + +
Sbjct: 1636 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ---ELEKQRQLAEGTAQ 1692
Query: 1707 VDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLAD--- 1763
++ AE+E++ E Q + +L+E R+ Q+R + LA
Sbjct: 1693 ----QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1748
Query: 1764 --ELINSGHSDA-----ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKE 1816
E++ + + A +T + K L EL + ++ A + E + A+E
Sbjct: 1749 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1808
Query: 1817 IFGRIQ-DKHKKLPEELGRDQNTVETLQRMHTTFE---HDIQALGTQVRQLQEDAA---- 1868
R + + + L E+L + R+ T E + +A ++R+L ED A
Sbjct: 1809 DAARQRAEAERVLAEKLA----AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1864
Query: 1869 RLQAAYAGDKAD------DIQKRENEVLEAWKSLL-DACESRR------VRLVDTGDKFR 1915
RL+ A KAD ++K + LE K L+ D RR + L + +K
Sbjct: 1865 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1924
Query: 1916 FFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGK 1975
+L L IR A++ R EL + + AE + R ++ K
Sbjct: 1925 AGKAELELELGR---IRS-NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--K 1978
Query: 1976 SL-----LARKHYASEEIKEKLLQLTEKRKEMIDKWE-DRWEWLRLILEVHQFSRDA-SV 2028
SL AR+ A+ E E+L E+ + + ++ E + L+L E Q A
Sbjct: 1979 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2038
Query: 2029 AEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVR 2088
A A+ + Q+ + + Q +++L EA ++A +E ER E + R
Sbjct: 2039 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER----EAAQSR 2094
Query: 2089 RQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDT- 2147
RQ EE ER ++ S E + +A++ + + EQ + AEQ + R + D
Sbjct: 2095 RQVEEAERLKQ--SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2152
Query: 2148 ---------------SEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPART 2192
+++ T R +E+ + + + A AA ++
Sbjct: 2153 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2212
Query: 2193 QE---TPSAQMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTA------ 2243
+E + QME K EA N+ R N + + + A+ A
Sbjct: 2213 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2272
Query: 2244 ---ASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKD-DEEMNTWI 2299
A+ + +E ++ + A+ E L K + RL E L Q K+ +E +
Sbjct: 2273 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2332
Query: 2300 QAISSAISSDKHEVSASTQSTPASSRAQTLPTS 2332
Q ++ E + Q T + R + L S
Sbjct: 2333 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2365
Score = 103 bits (257), Expect = 2e-21
Identities = 324/1635 (19%), Positives = 647/1635 (39%), Gaps = 194/1635 (11%)
Query: 677 LSKHRAFEDEMSGRSGHFEQAIKEGEDMIA--EEHFGSEKIRERIIYIREQWANLEQLSA 734
+++ + + E+ G + E E ++A E + +R + + + LSA
Sbjct: 1009 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1068
Query: 735 IRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEY-STQSLVKKHKDVAEEI 793
I ++L+ SL+ + A+++ + LK + E +T++ +KK + AE
Sbjct: 1069 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA- 1127
Query: 794 ANYRPTLDTLHEQ-------ASALPQEHAESPDV-----RGRLSGIEERYKEVAELTRLR 841
+PT D L ++ L Q H E DV R R++ + ER++ V T +R
Sbjct: 1128 --QQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERWRERVAQLLERWQAVLAQTDVR 1184
Query: 842 KQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPE 897
++ L+ + + E AD W+ + + +Q L D + ++ + ++L E
Sbjct: 1185 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-LADSQAVREQLRQEQALLEE 1243
Query: 898 MNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRE--LVDRKKDALLSAL 955
+ +V + A+Q +++ E ++ + +L S ++ + + + +
Sbjct: 1244 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1303
Query: 956 SIQNYHLECNETKS----WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 1011
++ ++ E S +I E + +E + L A Q++ ER L +EA
Sbjct: 1304 DLRTHYSELTTLTSQYIKFISETLRRMEEEERL--------AEQQRAEERER-LAEVEAA 1354
Query: 1012 LSDLQKEAE---KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFL 1068
L ++ AE + +++ +A+ + R+ E EE + ++ S+ E +LQQ L
Sbjct: 1355 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE--ELQQ-L 1411
Query: 1069 RDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV 1128
R + + Q A E + Q E + + E + Q +R E
Sbjct: 1412 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1471
Query: 1129 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQ 1188
+ AQ R R Q D E + + L S+ A + R+ ++A L +
Sbjct: 1472 EAQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEAEAAREKQRALQAL--E 1525
Query: 1189 EYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQE 1248
E L E L AE +++ ++ + A +++ R ++ +R
Sbjct: 1526 ELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1580
Query: 1249 KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-ELSLWINEKMLTAQDMSYDEAR 1307
S+ + H + E R + + ++ ++ + EL W + +EA
Sbjct: 1581 ---SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW---------QLKANEAL 1628
Query: 1308 NLH--SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTG--LHKMWE 1363
L ++ + Q +A+ + K+ K E E K E +AV + +L L K +
Sbjct: 1629 RLRLQAEEVAQQKSLAQAEAEKQ---KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1685
Query: 1364 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1423
+ E T Q QRL A + EL A+ ++ + Q+ ++ + +K+Q
Sbjct: 1686 LAEGTAQ---QRL--AAEQELIRLR-AETEQGEQ--QRQLLEEELARLQREAAAATQKRQ 1737
Query: 1424 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT-KFMELLEPLN------- 1475
LE ++ + E+E L + +E +ST E +RL + +F EL E
Sbjct: 1738 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1797
Query: 1476 --ERKHNLL---ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL 1530
+R+ L A+++ + R + +++ +GE L T + + +K+ +
Sbjct: 1798 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---------IALKEKEAE 1848
Query: 1531 QKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL-------LIEETEK 1583
+ ++ + D+ F+R + + + ++ I +RLA L++ L+E+T +
Sbjct: 1849 NERLR--RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1904
Query: 1584 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-----EQSAVSMLKKHQILE 1638
+ R++EE A + F+ A A E EL + A+D EQ+ + ++ Q+
Sbjct: 1905 QRRQVEEEILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAARQRQL-- 1961
Query: 1639 QAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERH 1698
A E+ + ++L A+ +R + + +V++L A +++ R E
Sbjct: 1962 -AAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESA 2019
Query: 1699 RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTV 1758
R QL +E E+ + Q+ + ++ + R + +
Sbjct: 2020 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE- 2078
Query: 1759 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA---- 1814
A+E +AA + E R Q AA+ +L K
Sbjct: 2079 ---AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2135
Query: 1815 ----------KEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQ 1864
K+ +KHKK E+ R + VE + TT ++ Q L
Sbjct: 2136 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE---QELTTLRLQLEETDHQKNLLD 2192
Query: 1865 EDAARL--QAAYAGDKADDIQKR------ENEVLEAWKSLLDACESRRVRLVDTGDKFRF 1916
E+ RL +A A + +++ + E L K+ ++A E+R + L D + RF
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRF 2251
Query: 1917 FSMVRDLMLWM-EDVIR-QIEAQE--KPRDVSSVELLMNN---HQGIKAEIDARNDSFTT 1969
+ M + E+ R + AQE + R ++ +L + +K ++ A ++ T
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA--T 2309
Query: 1970 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2029
++ LL ++ E +E+ +L E +++M + + + + LE + + A
Sbjct: 2310 RLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2366
Query: 2030 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLEVR 2088
EA L SR ++ ++ ++ K+ E EK T + E++T ++ LE++
Sbjct: 2367 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQ 2423
Query: 2089 RQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD-- 2146
RQQ + + +R E ++ E E QQ +K Q+ + Q + ET
Sbjct: 2424 RQQSDHDAER---LREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLLQETQALQ 2478
Query: 2147 ---TSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPS------ 2197
SE + +R +E + + D AK AQ R Q+
Sbjct: 2479 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK----AQQLREEQQRQQQQMEQERQRL 2534
Query: 2198 -AQMEGFLNRKHEWE 2211
A ME R+HE E
Sbjct: 2535 VASMEEARRRQHEAE 2549
Score = 100 bits (250), Expect = 1e-20
Identities = 306/1580 (19%), Positives = 623/1580 (39%), Gaps = 215/1580 (13%)
Query: 713 EKIRERIIYIREQWANLEQLSAIRKKRLEEASL-LHQFQADADDIDAWMLDI-------- 763
E+ RER+ + E+W + + +R++ LE+ L ++ AD + AW+ D
Sbjct: 1161 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1220
Query: 764 -LKIVSSSDVGHDEYSTQSL---VKKHKDVAEE-----------IANYRPTLDTLHEQAS 808
+ + S V Q+L +++H + EE I +Y L T Q
Sbjct: 1221 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1280
Query: 809 ALPQEHAESPDVRGRLSGIEERYKEV----AELTRLRKQALQDTLALYKMFSEADACELW 864
+ A+ P V+ + + Y ++ +ELT L Q + K SE L
Sbjct: 1281 PVASP-AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI-------KFISET----LR 1328
Query: 865 IDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS-- 922
E+E+ L Q E+ E L ++ E A A + A++L
Sbjct: 1329 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388
Query: 923 ---EKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIE 979
E + AQQ K + + + + + + +A + A + Q E + + I E+ +V+
Sbjct: 1389 RREEAAVDAQQQKRSIQ--EELQQLRQSSEAEIQAKARQAEAAERSRLR--IEEEIRVVR 1444
Query: 980 STQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL-------QKEAEKLESEHPDQAQA 1032
+ A +R+ G E +L A+ A+ + Q+EAE+L + D++Q
Sbjct: 1445 LQLE---------ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1495
Query: 1033 -------ILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLD-----DFQSWLSR 1080
+ SR+ ++ E + L+ E +A + ++ LR + Q L
Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1555
Query: 1081 TQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFL 1140
Q + +E + AEK +++ E ++R+ E Q Q +A+
Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEE----HVAVAQLREEAERRAQQQAEAE---- 1607
Query: 1141 RQRLQALDTGWNELHKMWENRQN------LLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH 1194
+A + EL + W+ + N L ++ A Q+ L QAEA +E A
Sbjct: 1608 ----RAREEAERELER-WQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQKEE---AE 1656
Query: 1195 TEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSID 1254
E + E A++++E + + +++ A +RL ++ + R +
Sbjct: 1657 REARRRGKAEEQAVRQRE--LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET------ 1708
Query: 1255 DRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWIN------EKMLTAQDMSYDEARN 1308
++ + R+ E L RL+ R+ Q QEL + E +L ++ + +E+R+
Sbjct: 1709 EQGEQQRQLLEEELARLQ--REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1766
Query: 1309 LHSKW---LKHQAF----MAELASNKEWLDKIEKEGMQLISE-----KPETEAVVKEKLT 1356
K L+ +A +AE A+ L + K QL E + E E V+ EKL
Sbjct: 1767 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1826
Query: 1357 GLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVN 1416
+ + + +T+A+ +AE D+ + Q+ + D+
Sbjct: 1827 AIGEATRL-----KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1881
Query: 1417 ILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNE 1476
L+K ++++E +K +E+ Q + + +E + K + + L +
Sbjct: 1882 AQLRKAS--DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1939
Query: 1477 RKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQG 1536
+ L SKE + + ++ ER +L + ++ + +E++
Sbjct: 1940 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1999
Query: 1537 HQPRIDD---IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHR 1593
+ ++++ + ER++ L+ EA ++RL ++ +++ E+ L++ +
Sbjct: 2000 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE---LQQTLQ 2056
Query: 1594 AQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVS---MLKKHQILEQAVEDYAETVHQ 1650
+Q D EA + + E + + E+ A +++ + L+Q+ E+ A+ Q
Sbjct: 2057 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2116
Query: 1651 LSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLF--QLNREVD 1708
+ L E+E+ + R+++ ++ K A+ E+H+ F Q R+
Sbjct: 2117 AQAAAEKL----RKEAEQEAARRAQAEQAALRQKQAADAEM----EKHKKFAEQTLRQKA 2168
Query: 1709 DLEQWIA--EREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDT---VNHLAD 1763
+EQ + ++ H+ E + L+ E AR + +E + L+
Sbjct: 2169 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2228
Query: 1764 ELINSGHSDAATIAEWKDG----LNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFG 1819
+ A I KD L E + ++ + ++ A+ E + A+E
Sbjct: 2229 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2288
Query: 1820 RIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKA 1879
+ + +K+ +E ++ +Q T + + + L Q QE A RLQ DK
Sbjct: 2289 QQRALAEKMLKE------KMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQE----DKE 2337
Query: 1880 DDIQKRENEVLEAWKSLLDACESRRVRLVDTGD--KFRFFSMVRDLMLWMEDVIR-QIEA 1936
Q+ E + ++ L+A R++ + + K R M R ED R + +A
Sbjct: 2338 QMAQQLAEET-QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2396
Query: 1937 QEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLT 1996
+E + EL + ++ + + + +E ++E + +L
Sbjct: 2397 EEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------QSDHDAERLREAIAEL- 2441
Query: 1997 EKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLI 2056
E+ KE K + + L+L E Q + + + Q+ +LS E + L+
Sbjct: 2442 EREKE---KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---------EKDSLL 2489
Query: 2057 KRHEAFEKSAATWDERFS-ALERLTTLELLEVRRQQE-EEERKRRPPSPEPSTKVSEEAE 2114
+R E+ A ++ F + + L + R+QQ+ E+ER+R S E + + EAE
Sbjct: 2490 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2549
Query: 2115 -----SQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPS 2169
Q++ + ++ Q L AE+ + R+ E + E + A + +S + +
Sbjct: 2550 EGVRRKQEELQQLEQQRRQQEELLAEE-NQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2608
Query: 2170 PTSDRKAKTALPAQSAATLP 2189
+ + AL +A P
Sbjct: 2609 TKTLPNGRDALDGPAAEAEP 2628
Score = 100 bits (249), Expect = 2e-20
Identities = 307/1564 (19%), Positives = 623/1564 (39%), Gaps = 209/1564 (13%)
Query: 384 REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLAR--RFDRKAA-MRETWLSE 440
R G+ ++ + ER+ + + L +RQ +LEQL R R+ R++A WL +
Sbjct: 1152 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1211
Query: 441 NQRLVSQDNFG--FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKR 498
+R Q D AV ++ +A+ +I + E+V+ A++
Sbjct: 1212 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY---------- 1261
Query: 499 ITARKDNVIRLWEY--LLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 556
I A KD ++L Y LE + + ++ ++ G + + QE + + E+ L+ Y
Sbjct: 1262 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL--TTLTSQY 1319
Query: 557 GKHLL-GVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAH 615
K + + + ++ L E + ER+ V A+ +K E + Q R+
Sbjct: 1320 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1379
Query: 616 MEFCYQELCQ-------LAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGK 668
+ +E+ + ++R+ EE ++L + AE + R+ E S +
Sbjct: 1380 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SEAEIQAKARQAEAAERSRLRIE 1437
Query: 669 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG---SEKIRERI--IYIR 723
+ V+RL + A E + G G + E+ A++ +E++R ++ R
Sbjct: 1438 EEIRVVRL--QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1495
Query: 724 EQWANLEQLSAIR------KKRLEEASLLHQFQADADDIDAWM----LDILKIVSSSDVG 773
++ A +E S ++ +++ L + + A++ + + ++ + V +
Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1555
Query: 774 HDEYSTQSLVKKHKDVAEEIANYRPTLDTLH-------EQASALPQEHAESPDVRGRLSG 826
+ L K AE+ A +L H E+A Q+ AE+ R
Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1615
Query: 827 IEERYK-EVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 885
ER++ + E RLR QA + +A K ++A+A + +KE+ + K E+
Sbjct: 1616 ELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQA 1669
Query: 886 VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 945
V Q E E Q + ++A + +E E QQ +L EL
Sbjct: 1670 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELAR 1724
Query: 946 RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL-----TG 1000
+++A +A + + LE K +R + +V+ +++ + + + + K G
Sbjct: 1725 LQREA--AAATQKRQELEAELAK--VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1780
Query: 1001 MERDLVAIEAKLSDLQKEA--------EKLESEHPDQAQAILSRLAEISDVWE---EMKT 1049
R+L A+L L +EA E + + + + +LA I + E +
Sbjct: 1781 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1840
Query: 1050 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1109
LK +EA E +L++ D + FQ Q A D+ L + K ++
Sbjct: 1841 ALKEKEA---ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRK--ASDSELER 1894
Query: 1110 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH-KMWENRQNLLSQS 1168
+ E+ ++ R Q + + + L+ + G EL ++ R N
Sbjct: 1895 QKGLVEDTLRQRR---------QVEEEILALKASFEKAAAGKAELELELGRIRSNA---- 1941
Query: 1169 HAYQQFLRDTKQAEAFLNNQEYVLAHTE---------MPTTLEGAEAAIKKQEDFMTTMD 1219
+ LR +QAE Q + A E + +L E A ++++ + +
Sbjct: 1942 ---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV- 1997
Query: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1279
E++ A VE RRL S R + + + E A ++ K+ ++LQ+
Sbjct: 1998 ---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQ 2053
Query: 1280 FLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ 1339
LQ Q + +++ + + A ++ + A+ E +++++ +
Sbjct: 2054 TLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2109
Query: 1340 LISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH-- 1397
+ + +A E L + +A R A +A L + AD + H
Sbjct: 2110 QAQARAQAQAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2158
Query: 1398 -GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA-QALSQEGKSTDE 1455
++ Q ++LT++ + L++ ++Q + +E++ L+++A +A Q + +E
Sbjct: 2159 FAEQTLRQKAQVEQELTTLRLQLEE---TDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2215
Query: 1456 VDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH 1515
+ S R VQ + + L+ E ++ L ++ R +++E E+M + +
Sbjct: 2216 LFSVR--VQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMK-QVAEEAAR 2268
Query: 1516 NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA------------- 1562
Q + Q ++++ + + + + V +++ L AEA
Sbjct: 2269 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2328
Query: 1563 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1622
R+ D +Q+ L EET+ R L EA R +Q AEA + + MS +A+
Sbjct: 2329 ARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQL---EMSAEAERLKLRVAEMSRAQAR 2384
Query: 1623 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVD--KLY 1680
E+ A Q + E+ E +H+ ++ V + ++ I +QS D +L
Sbjct: 2385 AEEDA-------QRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQSDHDAERLR 2435
Query: 1681 AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDY--EHVTMLQ- 1737
+ +L E+ KL + +L QL E Q + + +++ + L Q + E ++LQ
Sbjct: 2436 EAIAELEREKE-KLQQEAKLLQLKSEE---MQTVQQEQLLQETQALQQSFLSEKDSLLQR 2491
Query: 1738 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1797
ERF I QE+ DE +A+ + E ++ R
Sbjct: 2492 ERF---------IEQEKAKLEQLFQDE-----------VAKAQQLREEQQRQQQQMEQER 2531
Query: 1798 TQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALG 1857
+++A+ E + H+A+E R Q++ ++L ++ + + E L + +Q L
Sbjct: 2532 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE---ELLAEENQRLREQLQLLE 2588
Query: 1858 TQVR 1861
Q R
Sbjct: 2589 EQHR 2592
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 400 bits (1029), Expect = e-111
Identities = 575/2475 (23%), Positives = 1020/2475 (41%), Gaps = 325/2475 (13%)
Query: 50 DEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMR 109
DER+ VQKKTFTKWVN HL + I+DLY DLRDG LI LLEVLSG+ LP+ KGRMR
Sbjct: 38 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 96
Query: 110 IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDN 169
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGLIWTIIL FQI DI V +
Sbjct: 97 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 155
Query: 170 KEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSN 229
E +AK+ LLLW Q GY + NFT+SWRDG FNA+IH+H+P LID +K+ +
Sbjct: 156 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 214
Query: 230 AHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKR 289
NL AF++AE+ LG+T+LLDPED+ V PDEKSIITYV + Y ++ + +G R
Sbjct: 215 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 273
Query: 290 IGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRT 349
A E + ++Y L LL+W+ R+F +S ++ F ++
Sbjct: 274 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 326
Query: 350 VEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELA 409
+E P K +K + + +++ ++A KV G D+ K W +L A ERE
Sbjct: 327 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 383
Query: 410 LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIET 469
LR+E R E L+++ + +A + E L++ L+ D L A ++ +E
Sbjct: 384 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 440
Query: 470 DIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLG 529
D+ + ++ + + L+ + +++ R V RL E L+ + RL+ +
Sbjct: 441 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHERLVAIRTEYNLRLKAGVA 497
Query: 530 ----------LQKIFQE-------MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDLLQK 569
LQ + + + Y+ D W++E + V ++G L VE L
Sbjct: 498 APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 557
Query: 570 HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAE 629
H + + + A ++ +D P RD + ++ Y +L
Sbjct: 558 HRGLH-------QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLN---S 607
Query: 630 RRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSG 689
+ARL L F +E W+ EKE+ D+ T++ + A E+
Sbjct: 608 SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 667
Query: 690 RSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQF 749
+ ++ G+ ++ E+H + ++ QW+ + QL + L+E + QF
Sbjct: 668 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 727
Query: 750 QADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQ 806
+D + + + + L+ S D + L++ +D E++ Y+ L L ++
Sbjct: 728 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 787
Query: 807 ASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQALQDTLALYKMFSEADACEL 863
A A+ Q P +RGRL + YK+V E+T + D C+L
Sbjct: 788 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT----------------VHKGDECQL 830
Query: 864 WIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE 923
P + +V+ E + + V NQ A++ +
Sbjct: 831 ------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLVPPPNQEAQEAV------- 869
Query: 924 KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD 983
++AQ L T W Q VD K S L+ Q+ + +SW + ++ +
Sbjct: 870 TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQLIRSWSLATFRTLKPEE- 921
Query: 984 LGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV 1043
+ L ++E ++++ P+ S
Sbjct: 922 -----------------QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 964
Query: 1044 WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA-----------SEDMPN 1092
++++ L++ E E S+ Q+ + +L D + L +T + +
Sbjct: 965 YQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 1021
Query: 1093 TLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWN 1152
+ E +K + E + + + +K+ + E T LR L+ L G
Sbjct: 1022 RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT------LRSELE-LTLG-- 1072
Query: 1153 ELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-MPTT---LEGAEAAI 1208
+L ++ L + +R T+ AE L E L + +P T LE +A++
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132
Query: 1209 KK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINSDRIQEKVDSIDDRHRKNR 1261
KK E T DA +++ E G RL + ++ +R +E+V + +R +
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1192
Query: 1262 ETASELLMRLKD-NRDLQKFLQDCQELSLWINE---KMLTAQDMSYDEARNLHSKWLKHQ 1317
L+ R L+ + + L W+ + + Q M +++ + + + Q
Sbjct: 1193 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1252
Query: 1318 AFMAELASN-----------KEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLE 1366
A + E+ + K++++ I+ +QL++ K + E V K+ E
Sbjct: 1253 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP--AKKPKVQSGSE 1310
Query: 1367 STTQTKAQ-RLFDANKAELFTQSCADLDKWLHGLE-----SQIQSDDYGKDLTSVNILLK 1420
S Q R + L +Q + + L +E ++ Q + + L V L+
Sbjct: 1311 SVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE 1370
Query: 1421 KQQML-------ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEP 1473
KQ+ L + Q E KE+++ + Q + + +E + D KR ++Q + +L +
Sbjct: 1371 KQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKR-SIQEELQQLRQS 1428
Query: 1474 LNERKHNLLASKEIHQFNR-DVEDEILWVGERMPLATSTDHG---HNLQTVQLLIKKNQT 1529
E + +R +E+EI V ++ AT G LQ ++ ++ +
Sbjct: 1429 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE-ATERQRGGAEGELQALRARAEEAEA 1487
Query: 1530 LQKEIQGHQPR----IDDIFERSQNIVTDSSS---LSAEAIRQRLADLKQLWGLLI--EE 1580
+++ Q R + D +R + + +S AEA R++ L+ L L + EE
Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1547
Query: 1581 TEKRHRRLE-EAHRAQQYYFDAAE--AEAWMSEQ-----ELYMMSEEKAKDEQSAVSMLK 1632
E+R R+ E E R Q + A+ AEA + + E E ++E AV+ L+
Sbjct: 1548 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607
Query: 1633 K---------------HQILEQAVEDY-------------AETVHQLSKTSRALVADSHP 1664
+ + E+ +E + AE V Q ++A
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667
Query: 1665 ESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSH 1724
E+ER + R+ K ++ ++LAE+ +L+++ +L + + ++ AE+E++
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQ---ELEKQRQLAEGTAQ----QRLAAEQELIRLRA 1720
Query: 1725 ELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLAD-----ELINSGHSDA-----A 1774
E Q + +L+E R+ Q+R + LA E++ + + A +
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 1775 TIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQ-DKHKKLPEELG 1833
T + K L EL + ++ A + E + A+E R + + + L E+L
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 1834 RDQNTVETLQRMHTTFE---HDIQALGTQVRQLQEDAA----RLQAAYAGDKAD------ 1880
+ R+ T E + +A ++R+L ED A RL+ A KAD
Sbjct: 1841 ----AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896
Query: 1881 DIQKRENEVLEAWKSLL-DACESRR------VRLVDTGDKFRFFSMVRDLMLWMEDVIRQ 1933
++K + LE K L+ D RR + L + +K +L L IR
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR---IRS 1953
Query: 1934 IEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL-----LARKHYASEEI 1988
A++ R EL + + AE + R ++ KSL AR+ A+ E
Sbjct: 1954 -NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAARQRKAALEE 2010
Query: 1989 KEKLLQLTEKRKEMIDKWE-DRWEWLRLILEVHQFSRDA-SVAEAWLLGQEPYLSSREIG 2046
E+L E+ + + ++ E + L+L E Q A A A+ + Q+ + +
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070
Query: 2047 QSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPS 2106
Q +++L EA ++A +E ER E + RRQ EE ER ++ S E
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAER----EAAQSRRQVEEAERLKQ--SAEEQ 2124
Query: 2107 TKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDT----------------SEM 2150
+ +A++ + + EQ + AEQ + R + D +++
Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184
Query: 2151 VNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQE---TPSAQMEGFLNRK 2207
T R +E+ + + + A AA ++ +E + QME K
Sbjct: 2185 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2244
Query: 2208 HEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTA---------ASGIPYHSEVPVSLK 2258
EA N+ R N + + + A+ A A+ + +E ++ +
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304
Query: 2259 EAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKD-DEEMNTWIQAISSAISSDKHEVSAST 2317
A+ E L K + RL E L Q K+ +E +Q ++ E +
Sbjct: 2305 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2364
Query: 2318 QSTPASSRAQTLPTS 2332
Q T + R + L S
Sbjct: 2365 QRTLEAERQRQLEMS 2379
Score = 103 bits (257), Expect = 2e-21
Identities = 324/1635 (19%), Positives = 647/1635 (39%), Gaps = 194/1635 (11%)
Query: 677 LSKHRAFEDEMSGRSGHFEQAIKEGEDMIA--EEHFGSEKIRERIIYIREQWANLEQLSA 734
+++ + + E+ G + E E ++A E + +R + + + LSA
Sbjct: 1023 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1082
Query: 735 IRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEY-STQSLVKKHKDVAEEI 793
I ++L+ SL+ + A+++ + LK + E +T++ +KK + AE
Sbjct: 1083 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA- 1141
Query: 794 ANYRPTLDTLHEQ-------ASALPQEHAESPDV-----RGRLSGIEERYKEVAELTRLR 841
+PT D L ++ L Q H E DV R R++ + ER++ V T +R
Sbjct: 1142 --QQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERWRERVAQLLERWQAVLAQTDVR 1198
Query: 842 KQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPE 897
++ L+ + + E AD W+ + + +Q L D + ++ + ++L E
Sbjct: 1199 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-LADSQAVREQLRQEQALLEE 1257
Query: 898 MNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRE--LVDRKKDALLSAL 955
+ +V + A+Q +++ E ++ + +L S ++ + + + +
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1317
Query: 956 SIQNYHLECNETKS----WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 1011
++ ++ E S +I E + +E + L A Q++ ER L +EA
Sbjct: 1318 DLRTHYSELTTLTSQYIKFISETLRRMEEEERL--------AEQQRAEERER-LAEVEAA 1368
Query: 1012 LSDLQKEAE---KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFL 1068
L ++ AE + +++ +A+ + R+ E EE + ++ S+ E +LQQ L
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE--ELQQ-L 1425
Query: 1069 RDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV 1128
R + + Q A E + Q E + + E + Q +R E
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485
Query: 1129 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQ 1188
+ AQ R R Q D E + + L S+ A + R+ ++A L +
Sbjct: 1486 EAQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEAEAAREKQRALQAL--E 1539
Query: 1189 EYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQE 1248
E L E L AE +++ ++ + A +++ R ++ +R
Sbjct: 1540 ELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1594
Query: 1249 KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-ELSLWINEKMLTAQDMSYDEAR 1307
S+ + H + E R + + ++ ++ + EL W + +EA
Sbjct: 1595 ---SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW---------QLKANEAL 1642
Query: 1308 NLH--SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTG--LHKMWE 1363
L ++ + Q +A+ + K+ K E E K E +AV + +L L K +
Sbjct: 1643 RLRLQAEEVAQQKSLAQAEAEKQ---KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Query: 1364 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1423
+ E T Q QRL A + EL A+ ++ + Q+ ++ + +K+Q
Sbjct: 1700 LAEGTAQ---QRL--AAEQELIRLR-AETEQGEQ--QRQLLEEELARLQREAAAATQKRQ 1751
Query: 1424 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT-KFMELLEPLN------- 1475
LE ++ + E+E L + +E +ST E +RL + +F EL E
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 1476 --ERKHNLL---ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL 1530
+R+ L A+++ + R + +++ +GE L T + + +K+ +
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---------IALKEKEAE 1862
Query: 1531 QKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL-------LIEETEK 1583
+ ++ + D+ F+R + + + ++ I +RLA L++ L+E+T +
Sbjct: 1863 NERLR--RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1918
Query: 1584 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-----EQSAVSMLKKHQILE 1638
+ R++EE A + F+ A A E EL + A+D EQ+ + ++ Q+
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAARQRQL-- 1975
Query: 1639 QAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERH 1698
A E+ + ++L A+ +R + + +V++L A +++ R E
Sbjct: 1976 -AAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESA 2033
Query: 1699 RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTV 1758
R QL +E E+ + Q+ + ++ + R + +
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE- 2092
Query: 1759 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA---- 1814
A+E +AA + E R Q AA+ +L K
Sbjct: 2093 ---AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149
Query: 1815 ----------KEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQ 1864
K+ +KHKK E+ R + VE + TT ++ Q L
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE---QELTTLRLQLEETDHQKNLLD 2206
Query: 1865 EDAARL--QAAYAGDKADDIQKR------ENEVLEAWKSLLDACESRRVRLVDTGDKFRF 1916
E+ RL +A A + +++ + E L K+ ++A E+R + L D + RF
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRF 2265
Query: 1917 FSMVRDLMLWM-EDVIR-QIEAQE--KPRDVSSVELLMNN---HQGIKAEIDARNDSFTT 1969
+ M + E+ R + AQE + R ++ +L + +K ++ A ++ T
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA--T 2323
Query: 1970 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2029
++ LL ++ E +E+ +L E +++M + + + + LE + + A
Sbjct: 2324 RLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 2030 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLEVR 2088
EA L SR ++ ++ ++ K+ E EK T + E++T ++ LE++
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQ 2437
Query: 2089 RQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD-- 2146
RQQ + + +R E ++ E E QQ +K Q+ + Q + ET
Sbjct: 2438 RQQSDHDAER---LREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLLQETQALQ 2492
Query: 2147 ---TSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPS------ 2197
SE + +R +E + + D AK AQ R Q+
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK----AQQLREEQQRQQQQMEQERQRL 2548
Query: 2198 -AQMEGFLNRKHEWE 2211
A ME R+HE E
Sbjct: 2549 VASMEEARRRQHEAE 2563
Score = 100 bits (250), Expect = 1e-20
Identities = 306/1580 (19%), Positives = 623/1580 (39%), Gaps = 215/1580 (13%)
Query: 713 EKIRERIIYIREQWANLEQLSAIRKKRLEEASL-LHQFQADADDIDAWMLDI-------- 763
E+ RER+ + E+W + + +R++ LE+ L ++ AD + AW+ D
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234
Query: 764 -LKIVSSSDVGHDEYSTQSL---VKKHKDVAEE-----------IANYRPTLDTLHEQAS 808
+ + S V Q+L +++H + EE I +Y L T Q
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1294
Query: 809 ALPQEHAESPDVRGRLSGIEERYKEV----AELTRLRKQALQDTLALYKMFSEADACELW 864
+ A+ P V+ + + Y ++ +ELT L Q + K SE L
Sbjct: 1295 PVASP-AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI-------KFISET----LR 1342
Query: 865 IDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS-- 922
E+E+ L Q E+ E L ++ E A A + A++L
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 923 ---EKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIE 979
E + AQQ K + + + + + + +A + A + Q E + + I E+ +V+
Sbjct: 1403 RREEAAVDAQQQKRSIQ--EELQQLRQSSEAEIQAKARQAEAAERSRLR--IEEEIRVVR 1458
Query: 980 STQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL-------QKEAEKLESEHPDQAQA 1032
+ A +R+ G E +L A+ A+ + Q+EAE+L + D++Q
Sbjct: 1459 LQLE---------ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
Query: 1033 -------ILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLD-----DFQSWLSR 1080
+ SR+ ++ E + L+ E +A + ++ LR + Q L
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1569
Query: 1081 TQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFL 1140
Q + +E + AEK +++ E ++R+ E Q Q +A+
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEE----HVAVAQLREEAERRAQQQAEAE---- 1621
Query: 1141 RQRLQALDTGWNELHKMWENRQN------LLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH 1194
+A + EL + W+ + N L ++ A Q+ L QAEA +E A
Sbjct: 1622 ----RAREEAERELER-WQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQKEE---AE 1670
Query: 1195 TEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSID 1254
E + E A++++E + + +++ A +RL ++ + R +
Sbjct: 1671 REARRRGKAEEQAVRQRE--LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET------ 1722
Query: 1255 DRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWIN------EKMLTAQDMSYDEARN 1308
++ + R+ E L RL+ R+ Q QEL + E +L ++ + +E+R+
Sbjct: 1723 EQGEQQRQLLEEELARLQ--REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 1309 LHSKW---LKHQAF----MAELASNKEWLDKIEKEGMQLISE-----KPETEAVVKEKLT 1356
K L+ +A +AE A+ L + K QL E + E E V+ EKL
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 1357 GLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVN 1416
+ + + +T+A+ +AE D+ + Q+ + D+
Sbjct: 1841 AIGEATRL-----KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895
Query: 1417 ILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNE 1476
L+K ++++E +K +E+ Q + + +E + K + + L +
Sbjct: 1896 AQLRKAS--DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1953
Query: 1477 RKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQG 1536
+ L SKE + + ++ ER +L + ++ + +E++
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 1537 HQPRIDD---IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHR 1593
+ ++++ + ER++ L+ EA ++RL ++ +++ E+ L++ +
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE---LQQTLQ 2070
Query: 1594 AQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVS---MLKKHQILEQAVEDYAETVHQ 1650
+Q D EA + + E + + E+ A +++ + L+Q+ E+ A+ Q
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130
Query: 1651 LSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLF--QLNREVD 1708
+ L E+E+ + R+++ ++ K A+ E+H+ F Q R+
Sbjct: 2131 AQAAAEKL----RKEAEQEAARRAQAEQAALRQKQAADAEM----EKHKKFAEQTLRQKA 2182
Query: 1709 DLEQWIA--EREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDT---VNHLAD 1763
+EQ + ++ H+ E + L+ E AR + +E + L+
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2242
Query: 1764 ELINSGHSDAATIAEWKDG----LNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFG 1819
+ A I KD L E + ++ + ++ A+ E + A+E
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302
Query: 1820 RIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKA 1879
+ + +K+ +E ++ +Q T + + + L Q QE A RLQ DK
Sbjct: 2303 QQRALAEKMLKE------KMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQE----DKE 2351
Query: 1880 DDIQKRENEVLEAWKSLLDACESRRVRLVDTGD--KFRFFSMVRDLMLWMEDVIR-QIEA 1936
Q+ E + ++ L+A R++ + + K R M R ED R + +A
Sbjct: 2352 QMAQQLAEET-QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2410
Query: 1937 QEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLT 1996
+E + EL + ++ + + + +E ++E + +L
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------QSDHDAERLREAIAEL- 2455
Query: 1997 EKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLI 2056
E+ KE K + + L+L E Q + + + Q+ +LS E + L+
Sbjct: 2456 EREKE---KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---------EKDSLL 2503
Query: 2057 KRHEAFEKSAATWDERFS-ALERLTTLELLEVRRQQE-EEERKRRPPSPEPSTKVSEEAE 2114
+R E+ A ++ F + + L + R+QQ+ E+ER+R S E + + EAE
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563
Query: 2115 -----SQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPS 2169
Q++ + ++ Q L AE+ + R+ E + E + A + +S + +
Sbjct: 2564 EGVRRKQEELQQLEQQRRQQEELLAEE-NQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2622
Query: 2170 PTSDRKAKTALPAQSAATLP 2189
+ + AL +A P
Sbjct: 2623 TKTLPNGRDALDGPAAEAEP 2642
Score = 100 bits (249), Expect = 2e-20
Identities = 307/1564 (19%), Positives = 623/1564 (39%), Gaps = 209/1564 (13%)
Query: 384 REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLAR--RFDRKAA-MRETWLSE 440
R G+ ++ + ER+ + + L +RQ +LEQL R R+ R++A WL +
Sbjct: 1166 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1225
Query: 441 NQRLVSQDNFG--FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKR 498
+R Q D AV ++ +A+ +I + E+V+ A++
Sbjct: 1226 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY---------- 1275
Query: 499 ITARKDNVIRLWEY--LLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 556
I A KD ++L Y LE + + ++ ++ G + + QE + + E+ L+ Y
Sbjct: 1276 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL--TTLTSQY 1333
Query: 557 GKHLL-GVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAH 615
K + + + ++ L E + ER+ V A+ +K E + Q R+
Sbjct: 1334 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1393
Query: 616 MEFCYQELCQ-------LAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGK 668
+ +E+ + ++R+ EE ++L + AE + R+ E S +
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SEAEIQAKARQAEAAERSRLRIE 1451
Query: 669 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG---SEKIRERI--IYIR 723
+ V+RL + A E + G G + E+ A++ +E++R ++ R
Sbjct: 1452 EEIRVVRL--QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
Query: 724 EQWANLEQLSAIR------KKRLEEASLLHQFQADADDIDAWM----LDILKIVSSSDVG 773
++ A +E S ++ +++ L + + A++ + + ++ + V +
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1569
Query: 774 HDEYSTQSLVKKHKDVAEEIANYRPTLDTLH-------EQASALPQEHAESPDVRGRLSG 826
+ L K AE+ A +L H E+A Q+ AE+ R
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629
Query: 827 IEERYK-EVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 885
ER++ + E RLR QA + +A K ++A+A + +KE+ + K E+
Sbjct: 1630 ELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQA 1683
Query: 886 VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 945
V Q E E Q + ++A + +E E QQ +L EL
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELAR 1738
Query: 946 RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL-----TG 1000
+++A +A + + LE K +R + +V+ +++ + + + + K G
Sbjct: 1739 LQREA--AAATQKRQELEAELAK--VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794
Query: 1001 MERDLVAIEAKLSDLQKEA--------EKLESEHPDQAQAILSRLAEISDVWE---EMKT 1049
R+L A+L L +EA E + + + + +LA I + E +
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1854
Query: 1050 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1109
LK +EA E +L++ D + FQ Q A D+ L + K ++
Sbjct: 1855 ALKEKEA---ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRK--ASDSELER 1908
Query: 1110 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH-KMWENRQNLLSQS 1168
+ E+ ++ R Q + + + L+ + G EL ++ R N
Sbjct: 1909 QKGLVEDTLRQRR---------QVEEEILALKASFEKAAAGKAELELELGRIRSNA---- 1955
Query: 1169 HAYQQFLRDTKQAEAFLNNQEYVLAHTE---------MPTTLEGAEAAIKKQEDFMTTMD 1219
+ LR +QAE Q + A E + +L E A ++++ + +
Sbjct: 1956 ---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV- 2011
Query: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1279
E++ A VE RRL S R + + + E A ++ K+ ++LQ+
Sbjct: 2012 ---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQ 2067
Query: 1280 FLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ 1339
LQ Q + +++ + + A ++ + A+ E +++++ +
Sbjct: 2068 TLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123
Query: 1340 LISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH-- 1397
+ + +A E L + +A R A +A L + AD + H
Sbjct: 2124 QAQARAQAQAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172
Query: 1398 -GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA-QALSQEGKSTDE 1455
++ Q ++LT++ + L++ ++Q + +E++ L+++A +A Q + +E
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEE---TDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229
Query: 1456 VDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH 1515
+ S R VQ + + L+ E ++ L ++ R +++E E+M + +
Sbjct: 2230 LFSVR--VQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMK-QVAEEAAR 2282
Query: 1516 NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA------------- 1562
Q + Q ++++ + + + + V +++ L AEA
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2342
Query: 1563 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1622
R+ D +Q+ L EET+ R L EA R +Q AEA + + MS +A+
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQL---EMSAEAERLKLRVAEMSRAQAR 2398
Query: 1623 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVD--KLY 1680
E+ A Q + E+ E +H+ ++ V + ++ I +QS D +L
Sbjct: 2399 AEEDA-------QRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQSDHDAERLR 2449
Query: 1681 AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDY--EHVTMLQ- 1737
+ +L E+ KL + +L QL E Q + + +++ + L Q + E ++LQ
Sbjct: 2450 EAIAELEREKE-KLQQEAKLLQLKSEE---MQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 1738 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1797
ERF I QE+ DE +A+ + E ++ R
Sbjct: 2506 ERF---------IEQEKAKLEQLFQDE-----------VAKAQQLREEQQRQQQQMEQER 2545
Query: 1798 TQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALG 1857
+++A+ E + H+A+E R Q++ ++L ++ + + E L + +Q L
Sbjct: 2546 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE---ELLAEENQRLREQLQLLE 2602
Query: 1858 TQVR 1861
Q R
Sbjct: 2603 EQHR 2606
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 400 bits (1029), Expect = e-111
Identities = 575/2475 (23%), Positives = 1020/2475 (41%), Gaps = 325/2475 (13%)
Query: 50 DEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMR 109
DER+ VQKKTFTKWVN HL + I+DLY DLRDG LI LLEVLSG+ LP+ KGRMR
Sbjct: 42 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 100
Query: 110 IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDN 169
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGLIWTIIL FQI DI V +
Sbjct: 101 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 159
Query: 170 KEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSN 229
E +AK+ LLLW Q GY + NFT+SWRDG FNA+IH+H+P LID +K+ +
Sbjct: 160 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 218
Query: 230 AHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKR 289
NL AF++AE+ LG+T+LLDPED+ V PDEKSIITYV + Y ++ + +G R
Sbjct: 219 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 277
Query: 290 IGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRT 349
A E + ++Y L LL+W+ R+F +S ++ F ++
Sbjct: 278 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 330
Query: 350 VEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELA 409
+E P K +K + + +++ ++A KV G D+ K W +L A ERE
Sbjct: 331 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 387
Query: 410 LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIET 469
LR+E R E L+++ + +A + E L++ L+ D L A ++ +E
Sbjct: 388 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 444
Query: 470 DIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLG 529
D+ + ++ + + L+ + +++ R V RL E L+ + RL+ +
Sbjct: 445 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHERLVAIRTEYNLRLKAGVA 501
Query: 530 ----------LQKIFQE-------MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDLLQK 569
LQ + + + Y+ D W++E + V ++G L VE L
Sbjct: 502 APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 561
Query: 570 HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAE 629
H + + + A ++ +D P RD + ++ Y +L
Sbjct: 562 HRGLH-------QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLN---S 611
Query: 630 RRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSG 689
+ARL L F +E W+ EKE+ D+ T++ + A E+
Sbjct: 612 SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 671
Query: 690 RSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQF 749
+ ++ G+ ++ E+H + ++ QW+ + QL + L+E + QF
Sbjct: 672 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 731
Query: 750 QADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQ 806
+D + + + + L+ S D + L++ +D E++ Y+ L L ++
Sbjct: 732 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 791
Query: 807 ASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQALQDTLALYKMFSEADACEL 863
A A+ Q P +RGRL + YK+V E+T + D C+L
Sbjct: 792 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT----------------VHKGDECQL 834
Query: 864 WIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE 923
P + +V+ E + + V NQ A++ +
Sbjct: 835 ------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLVPPPNQEAQEAV------- 873
Query: 924 KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD 983
++AQ L T W Q VD K S L+ Q+ + +SW + ++ +
Sbjct: 874 TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQLIRSWSLATFRTLKPEE- 925
Query: 984 LGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV 1043
+ L ++E ++++ P+ S
Sbjct: 926 -----------------QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 968
Query: 1044 WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA-----------SEDMPN 1092
++++ L++ E E S+ Q+ + +L D + L +T + +
Sbjct: 969 YQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 1025
Query: 1093 TLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWN 1152
+ E +K + E + + + +K+ + E T LR L+ L G
Sbjct: 1026 RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT------LRSELE-LTLG-- 1076
Query: 1153 ELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-MPTT---LEGAEAAI 1208
+L ++ L + +R T+ AE L E L + +P T LE +A++
Sbjct: 1077 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1136
Query: 1209 KK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINSDRIQEKVDSIDDRHRKNR 1261
KK E T DA +++ E G RL + ++ +R +E+V + +R +
Sbjct: 1137 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1196
Query: 1262 ETASELLMRLKD-NRDLQKFLQDCQELSLWINE---KMLTAQDMSYDEARNLHSKWLKHQ 1317
L+ R L+ + + L W+ + + Q M +++ + + + Q
Sbjct: 1197 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1256
Query: 1318 AFMAELASN-----------KEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLE 1366
A + E+ + K++++ I+ +QL++ K + E V K+ E
Sbjct: 1257 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP--AKKPKVQSGSE 1314
Query: 1367 STTQTKAQ-RLFDANKAELFTQSCADLDKWLHGLE-----SQIQSDDYGKDLTSVNILLK 1420
S Q R + L +Q + + L +E ++ Q + + L V L+
Sbjct: 1315 SVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE 1374
Query: 1421 KQQML-------ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEP 1473
KQ+ L + Q E KE+++ + Q + + +E + D KR ++Q + +L +
Sbjct: 1375 KQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKR-SIQEELQQLRQS 1432
Query: 1474 LNERKHNLLASKEIHQFNR-DVEDEILWVGERMPLATSTDHG---HNLQTVQLLIKKNQT 1529
E + +R +E+EI V ++ AT G LQ ++ ++ +
Sbjct: 1433 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE-ATERQRGGAEGELQALRARAEEAEA 1491
Query: 1530 LQKEIQGHQPR----IDDIFERSQNIVTDSSS---LSAEAIRQRLADLKQLWGLLI--EE 1580
+++ Q R + D +R + + +S AEA R++ L+ L L + EE
Sbjct: 1492 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1551
Query: 1581 TEKRHRRLE-EAHRAQQYYFDAAE--AEAWMSEQ-----ELYMMSEEKAKDEQSAVSMLK 1632
E+R R+ E E R Q + A+ AEA + + E E ++E AV+ L+
Sbjct: 1552 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1611
Query: 1633 K---------------HQILEQAVEDY-------------AETVHQLSKTSRALVADSHP 1664
+ + E+ +E + AE V Q ++A
Sbjct: 1612 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1671
Query: 1665 ESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSH 1724
E+ER + R+ K ++ ++LAE+ +L+++ +L + + ++ AE+E++
Sbjct: 1672 EAEREARRRGKAEEQAVRQRELAEQ---ELEKQRQLAEGTAQ----QRLAAEQELIRLRA 1724
Query: 1725 ELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLAD-----ELINSGHSDA-----A 1774
E Q + +L+E R+ Q+R + LA E++ + + A +
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1784
Query: 1775 TIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQ-DKHKKLPEELG 1833
T + K L EL + ++ A + E + A+E R + + + L E+L
Sbjct: 1785 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1844
Query: 1834 RDQNTVETLQRMHTTFE---HDIQALGTQVRQLQEDAA----RLQAAYAGDKAD------ 1880
+ R+ T E + +A ++R+L ED A RL+ A KAD
Sbjct: 1845 ----AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1900
Query: 1881 DIQKRENEVLEAWKSLL-DACESRR------VRLVDTGDKFRFFSMVRDLMLWMEDVIRQ 1933
++K + LE K L+ D RR + L + +K +L L IR
Sbjct: 1901 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR---IRS 1957
Query: 1934 IEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL-----LARKHYASEEI 1988
A++ R EL + + AE + R ++ KSL AR+ A+ E
Sbjct: 1958 -NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAARQRKAALEE 2014
Query: 1989 KEKLLQLTEKRKEMIDKWE-DRWEWLRLILEVHQFSRDA-SVAEAWLLGQEPYLSSREIG 2046
E+L E+ + + ++ E + L+L E Q A A A+ + Q+ + +
Sbjct: 2015 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2074
Query: 2047 QSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPS 2106
Q +++L EA ++A +E ER E + RRQ EE ER ++ S E
Sbjct: 2075 QEQSVLDQLRGEAEAARRAAEEAEEARVQAER----EAAQSRRQVEEAERLKQ--SAEEQ 2128
Query: 2107 TKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDT----------------SEM 2150
+ +A++ + + EQ + AEQ + R + D +++
Sbjct: 2129 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2188
Query: 2151 VNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQE---TPSAQMEGFLNRK 2207
T R +E+ + + + A AA ++ +E + QME K
Sbjct: 2189 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2248
Query: 2208 HEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTA---------ASGIPYHSEVPVSLK 2258
EA N+ R N + + + A+ A A+ + +E ++ +
Sbjct: 2249 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2308
Query: 2259 EAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKD-DEEMNTWIQAISSAISSDKHEVSAST 2317
A+ E L K + RL E L Q K+ +E +Q ++ E +
Sbjct: 2309 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2368
Query: 2318 QSTPASSRAQTLPTS 2332
Q T + R + L S
Sbjct: 2369 QRTLEAERQRQLEMS 2383
Score = 103 bits (257), Expect = 2e-21
Identities = 324/1635 (19%), Positives = 647/1635 (39%), Gaps = 194/1635 (11%)
Query: 677 LSKHRAFEDEMSGRSGHFEQAIKEGEDMIA--EEHFGSEKIRERIIYIREQWANLEQLSA 734
+++ + + E+ G + E E ++A E + +R + + + LSA
Sbjct: 1027 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1086
Query: 735 IRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEY-STQSLVKKHKDVAEEI 793
I ++L+ SL+ + A+++ + LK + E +T++ +KK + AE
Sbjct: 1087 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA- 1145
Query: 794 ANYRPTLDTLHEQ-------ASALPQEHAESPDV-----RGRLSGIEERYKEVAELTRLR 841
+PT D L ++ L Q H E DV R R++ + ER++ V T +R
Sbjct: 1146 --QQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERWRERVAQLLERWQAVLAQTDVR 1202
Query: 842 KQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPE 897
++ L+ + + E AD W+ + + +Q L D + ++ + ++L E
Sbjct: 1203 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-LADSQAVREQLRQEQALLEE 1261
Query: 898 MNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRE--LVDRKKDALLSAL 955
+ +V + A+Q +++ E ++ + +L S ++ + + + +
Sbjct: 1262 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1321
Query: 956 SIQNYHLECNETKS----WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 1011
++ ++ E S +I E + +E + L A Q++ ER L +EA
Sbjct: 1322 DLRTHYSELTTLTSQYIKFISETLRRMEEEERL--------AEQQRAEERER-LAEVEAA 1372
Query: 1012 LSDLQKEAE---KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFL 1068
L ++ AE + +++ +A+ + R+ E EE + ++ S+ E +LQQ L
Sbjct: 1373 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE--ELQQ-L 1429
Query: 1069 RDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV 1128
R + + Q A E + Q E + + E + Q +R E
Sbjct: 1430 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1489
Query: 1129 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQ 1188
+ AQ R R Q D E + + L S+ A + R+ ++A L +
Sbjct: 1490 EAQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEAEAAREKQRALQAL--E 1543
Query: 1189 EYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQE 1248
E L E L AE +++ ++ + A +++ R ++ +R
Sbjct: 1544 ELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1598
Query: 1249 KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-ELSLWINEKMLTAQDMSYDEAR 1307
S+ + H + E R + + ++ ++ + EL W + +EA
Sbjct: 1599 ---SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW---------QLKANEAL 1646
Query: 1308 NLH--SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTG--LHKMWE 1363
L ++ + Q +A+ + K+ K E E K E +AV + +L L K +
Sbjct: 1647 RLRLQAEEVAQQKSLAQAEAEKQ---KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1703
Query: 1364 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1423
+ E T Q QRL A + EL A+ ++ + Q+ ++ + +K+Q
Sbjct: 1704 LAEGTAQ---QRL--AAEQELIRLR-AETEQGEQ--QRQLLEEELARLQREAAAATQKRQ 1755
Query: 1424 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT-KFMELLEPLN------- 1475
LE ++ + E+E L + +E +ST E +RL + +F EL E
Sbjct: 1756 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1815
Query: 1476 --ERKHNLL---ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL 1530
+R+ L A+++ + R + +++ +GE L T + + +K+ +
Sbjct: 1816 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---------IALKEKEAE 1866
Query: 1531 QKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL-------LIEETEK 1583
+ ++ + D+ F+R + + + ++ I +RLA L++ L+E+T +
Sbjct: 1867 NERLR--RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1922
Query: 1584 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-----EQSAVSMLKKHQILE 1638
+ R++EE A + F+ A A E EL + A+D EQ+ + ++ Q+
Sbjct: 1923 QRRQVEEEILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAARQRQL-- 1979
Query: 1639 QAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERH 1698
A E+ + ++L A+ +R + + +V++L A +++ R E
Sbjct: 1980 -AAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESA 2037
Query: 1699 RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTV 1758
R QL +E E+ + Q+ + ++ + R + +
Sbjct: 2038 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE- 2096
Query: 1759 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA---- 1814
A+E +AA + E R Q AA+ +L K
Sbjct: 2097 ---AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2153
Query: 1815 ----------KEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQ 1864
K+ +KHKK E+ R + VE + TT ++ Q L
Sbjct: 2154 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE---QELTTLRLQLEETDHQKNLLD 2210
Query: 1865 EDAARL--QAAYAGDKADDIQKR------ENEVLEAWKSLLDACESRRVRLVDTGDKFRF 1916
E+ RL +A A + +++ + E L K+ ++A E+R + L D + RF
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRF 2269
Query: 1917 FSMVRDLMLWM-EDVIR-QIEAQE--KPRDVSSVELLMNN---HQGIKAEIDARNDSFTT 1969
+ M + E+ R + AQE + R ++ +L + +K ++ A ++ T
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA--T 2327
Query: 1970 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2029
++ LL ++ E +E+ +L E +++M + + + + LE + + A
Sbjct: 2328 RLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2384
Query: 2030 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLEVR 2088
EA L SR ++ ++ ++ K+ E EK T + E++T ++ LE++
Sbjct: 2385 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQ 2441
Query: 2089 RQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD-- 2146
RQQ + + +R E ++ E E QQ +K Q+ + Q + ET
Sbjct: 2442 RQQSDHDAER---LREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLLQETQALQ 2496
Query: 2147 ---TSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPS------ 2197
SE + +R +E + + D AK AQ R Q+
Sbjct: 2497 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK----AQQLREEQQRQQQQMEQERQRL 2552
Query: 2198 -AQMEGFLNRKHEWE 2211
A ME R+HE E
Sbjct: 2553 VASMEEARRRQHEAE 2567
Score = 100 bits (250), Expect = 1e-20
Identities = 306/1580 (19%), Positives = 623/1580 (39%), Gaps = 215/1580 (13%)
Query: 713 EKIRERIIYIREQWANLEQLSAIRKKRLEEASL-LHQFQADADDIDAWMLDI-------- 763
E+ RER+ + E+W + + +R++ LE+ L ++ AD + AW+ D
Sbjct: 1179 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1238
Query: 764 -LKIVSSSDVGHDEYSTQSL---VKKHKDVAEE-----------IANYRPTLDTLHEQAS 808
+ + S V Q+L +++H + EE I +Y L T Q
Sbjct: 1239 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1298
Query: 809 ALPQEHAESPDVRGRLSGIEERYKEV----AELTRLRKQALQDTLALYKMFSEADACELW 864
+ A+ P V+ + + Y ++ +ELT L Q + K SE L
Sbjct: 1299 PVASP-AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI-------KFISET----LR 1346
Query: 865 IDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS-- 922
E+E+ L Q E+ E L ++ E A A + A++L
Sbjct: 1347 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406
Query: 923 ---EKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIE 979
E + AQQ K + + + + + + +A + A + Q E + + I E+ +V+
Sbjct: 1407 RREEAAVDAQQQKRSIQ--EELQQLRQSSEAEIQAKARQAEAAERSRLR--IEEEIRVVR 1462
Query: 980 STQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL-------QKEAEKLESEHPDQAQA 1032
+ A +R+ G E +L A+ A+ + Q+EAE+L + D++Q
Sbjct: 1463 LQLE---------ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513
Query: 1033 -------ILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLD-----DFQSWLSR 1080
+ SR+ ++ E + L+ E +A + ++ LR + Q L
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1573
Query: 1081 TQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFL 1140
Q + +E + AEK +++ E ++R+ E Q Q +A+
Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEE----HVAVAQLREEAERRAQQQAEAE---- 1625
Query: 1141 RQRLQALDTGWNELHKMWENRQN------LLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH 1194
+A + EL + W+ + N L ++ A Q+ L QAEA +E A
Sbjct: 1626 ----RAREEAERELER-WQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQKEE---AE 1674
Query: 1195 TEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSID 1254
E + E A++++E + + +++ A +RL ++ + R +
Sbjct: 1675 REARRRGKAEEQAVRQRE--LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET------ 1726
Query: 1255 DRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWIN------EKMLTAQDMSYDEARN 1308
++ + R+ E L RL+ R+ Q QEL + E +L ++ + +E+R+
Sbjct: 1727 EQGEQQRQLLEEELARLQ--REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1784
Query: 1309 LHSKW---LKHQAF----MAELASNKEWLDKIEKEGMQLISE-----KPETEAVVKEKLT 1356
K L+ +A +AE A+ L + K QL E + E E V+ EKL
Sbjct: 1785 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1844
Query: 1357 GLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVN 1416
+ + + +T+A+ +AE D+ + Q+ + D+
Sbjct: 1845 AIGEATRL-----KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1899
Query: 1417 ILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNE 1476
L+K ++++E +K +E+ Q + + +E + K + + L +
Sbjct: 1900 AQLRKAS--DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1957
Query: 1477 RKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQG 1536
+ L SKE + + ++ ER +L + ++ + +E++
Sbjct: 1958 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2017
Query: 1537 HQPRIDD---IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHR 1593
+ ++++ + ER++ L+ EA ++RL ++ +++ E+ L++ +
Sbjct: 2018 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE---LQQTLQ 2074
Query: 1594 AQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVS---MLKKHQILEQAVEDYAETVHQ 1650
+Q D EA + + E + + E+ A +++ + L+Q+ E+ A+ Q
Sbjct: 2075 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2134
Query: 1651 LSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLF--QLNREVD 1708
+ L E+E+ + R+++ ++ K A+ E+H+ F Q R+
Sbjct: 2135 AQAAAEKL----RKEAEQEAARRAQAEQAALRQKQAADAEM----EKHKKFAEQTLRQKA 2186
Query: 1709 DLEQWIA--EREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDT---VNHLAD 1763
+EQ + ++ H+ E + L+ E AR + +E + L+
Sbjct: 2187 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2246
Query: 1764 ELINSGHSDAATIAEWKDG----LNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFG 1819
+ A I KD L E + ++ + ++ A+ E + A+E
Sbjct: 2247 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2306
Query: 1820 RIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKA 1879
+ + +K+ +E ++ +Q T + + + L Q QE A RLQ DK
Sbjct: 2307 QQRALAEKMLKE------KMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQE----DKE 2355
Query: 1880 DDIQKRENEVLEAWKSLLDACESRRVRLVDTGD--KFRFFSMVRDLMLWMEDVIR-QIEA 1936
Q+ E + ++ L+A R++ + + K R M R ED R + +A
Sbjct: 2356 QMAQQLAEET-QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2414
Query: 1937 QEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLT 1996
+E + EL + ++ + + + +E ++E + +L
Sbjct: 2415 EEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------QSDHDAERLREAIAEL- 2459
Query: 1997 EKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLI 2056
E+ KE K + + L+L E Q + + + Q+ +LS E + L+
Sbjct: 2460 EREKE---KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---------EKDSLL 2507
Query: 2057 KRHEAFEKSAATWDERFS-ALERLTTLELLEVRRQQE-EEERKRRPPSPEPSTKVSEEAE 2114
+R E+ A ++ F + + L + R+QQ+ E+ER+R S E + + EAE
Sbjct: 2508 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2567
Query: 2115 -----SQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPS 2169
Q++ + ++ Q L AE+ + R+ E + E + A + +S + +
Sbjct: 2568 EGVRRKQEELQQLEQQRRQQEELLAEE-NQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2626
Query: 2170 PTSDRKAKTALPAQSAATLP 2189
+ + AL +A P
Sbjct: 2627 TKTLPNGRDALDGPAAEAEP 2646
Score = 100 bits (249), Expect = 2e-20
Identities = 307/1564 (19%), Positives = 623/1564 (39%), Gaps = 209/1564 (13%)
Query: 384 REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLAR--RFDRKAA-MRETWLSE 440
R G+ ++ + ER+ + + L +RQ +LEQL R R+ R++A WL +
Sbjct: 1170 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1229
Query: 441 NQRLVSQDNFG--FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKR 498
+R Q D AV ++ +A+ +I + E+V+ A++
Sbjct: 1230 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY---------- 1279
Query: 499 ITARKDNVIRLWEY--LLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 556
I A KD ++L Y LE + + ++ ++ G + + QE + + E+ L+ Y
Sbjct: 1280 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL--TTLTSQY 1337
Query: 557 GKHLL-GVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAH 615
K + + + ++ L E + ER+ V A+ +K E + Q R+
Sbjct: 1338 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1397
Query: 616 MEFCYQELCQ-------LAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGK 668
+ +E+ + ++R+ EE ++L + AE + R+ E S +
Sbjct: 1398 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SEAEIQAKARQAEAAERSRLRIE 1455
Query: 669 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG---SEKIRERI--IYIR 723
+ V+RL + A E + G G + E+ A++ +E++R ++ R
Sbjct: 1456 EEIRVVRL--QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513
Query: 724 EQWANLEQLSAIR------KKRLEEASLLHQFQADADDIDAWM----LDILKIVSSSDVG 773
++ A +E S ++ +++ L + + A++ + + ++ + V +
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1573
Query: 774 HDEYSTQSLVKKHKDVAEEIANYRPTLDTLH-------EQASALPQEHAESPDVRGRLSG 826
+ L K AE+ A +L H E+A Q+ AE+ R
Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1633
Query: 827 IEERYK-EVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 885
ER++ + E RLR QA + +A K ++A+A + +KE+ + K E+
Sbjct: 1634 ELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQA 1687
Query: 886 VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 945
V Q E E Q + ++A + +E E QQ +L EL
Sbjct: 1688 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELAR 1742
Query: 946 RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL-----TG 1000
+++A +A + + LE K +R + +V+ +++ + + + + K G
Sbjct: 1743 LQREA--AAATQKRQELEAELAK--VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1798
Query: 1001 MERDLVAIEAKLSDLQKEA--------EKLESEHPDQAQAILSRLAEISDVWE---EMKT 1049
R+L A+L L +EA E + + + + +LA I + E +
Sbjct: 1799 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1858
Query: 1050 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1109
LK +EA E +L++ D + FQ Q A D+ L + K ++
Sbjct: 1859 ALKEKEA---ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRK--ASDSELER 1912
Query: 1110 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH-KMWENRQNLLSQS 1168
+ E+ ++ R Q + + + L+ + G EL ++ R N
Sbjct: 1913 QKGLVEDTLRQRR---------QVEEEILALKASFEKAAAGKAELELELGRIRSNA---- 1959
Query: 1169 HAYQQFLRDTKQAEAFLNNQEYVLAHTE---------MPTTLEGAEAAIKKQEDFMTTMD 1219
+ LR +QAE Q + A E + +L E A ++++ + +
Sbjct: 1960 ---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV- 2015
Query: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1279
E++ A VE RRL S R + + + E A ++ K+ ++LQ+
Sbjct: 2016 ---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQ 2071
Query: 1280 FLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ 1339
LQ Q + +++ + + A ++ + A+ E +++++ +
Sbjct: 2072 TLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2127
Query: 1340 LISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH-- 1397
+ + +A E L + +A R A +A L + AD + H
Sbjct: 2128 QAQARAQAQAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2176
Query: 1398 -GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA-QALSQEGKSTDE 1455
++ Q ++LT++ + L++ ++Q + +E++ L+++A +A Q + +E
Sbjct: 2177 FAEQTLRQKAQVEQELTTLRLQLEE---TDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2233
Query: 1456 VDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH 1515
+ S R VQ + + L+ E ++ L ++ R +++E E+M + +
Sbjct: 2234 LFSVR--VQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMK-QVAEEAAR 2286
Query: 1516 NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA------------- 1562
Q + Q ++++ + + + + V +++ L AEA
Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2346
Query: 1563 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1622
R+ D +Q+ L EET+ R L EA R +Q AEA + + MS +A+
Sbjct: 2347 ARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQL---EMSAEAERLKLRVAEMSRAQAR 2402
Query: 1623 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVD--KLY 1680
E+ A Q + E+ E +H+ ++ V + ++ I +QS D +L
Sbjct: 2403 AEEDA-------QRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQSDHDAERLR 2453
Query: 1681 AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDY--EHVTMLQ- 1737
+ +L E+ KL + +L QL E Q + + +++ + L Q + E ++LQ
Sbjct: 2454 EAIAELEREKE-KLQQEAKLLQLKSEE---MQTVQQEQLLQETQALQQSFLSEKDSLLQR 2509
Query: 1738 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1797
ERF I QE+ DE +A+ + E ++ R
Sbjct: 2510 ERF---------IEQEKAKLEQLFQDE-----------VAKAQQLREEQQRQQQQMEQER 2549
Query: 1798 TQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALG 1857
+++A+ E + H+A+E R Q++ ++L ++ + + E L + +Q L
Sbjct: 2550 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE---ELLAEENQRLREQLQLLE 2606
Query: 1858 TQVR 1861
Q R
Sbjct: 2607 EQHR 2610
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 400 bits (1029), Expect = e-111
Identities = 575/2475 (23%), Positives = 1020/2475 (41%), Gaps = 325/2475 (13%)
Query: 50 DEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMR 109
DER+ VQKKTFTKWVN HL + I+DLY DLRDG LI LLEVLSG+ LP+ KGRMR
Sbjct: 38 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 96
Query: 110 IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDN 169
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGLIWTIIL FQI DI V +
Sbjct: 97 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 155
Query: 170 KEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSN 229
E +AK+ LLLW Q GY + NFT+SWRDG FNA+IH+H+P LID +K+ +
Sbjct: 156 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 214
Query: 230 AHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKR 289
NL AF++AE+ LG+T+LLDPED+ V PDEKSIITYV + Y ++ + +G R
Sbjct: 215 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 273
Query: 290 IGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRT 349
A E + ++Y L LL+W+ R+F +S ++ F ++
Sbjct: 274 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 326
Query: 350 VEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELA 409
+E P K +K + + +++ ++A KV G D+ K W +L A ERE
Sbjct: 327 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 383
Query: 410 LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIET 469
LR+E R E L+++ + +A + E L++ L+ D L A ++ +E
Sbjct: 384 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 440
Query: 470 DIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLG 529
D+ + ++ + + L+ + +++ R V RL E L+ + RL+ +
Sbjct: 441 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHERLVAIRTEYNLRLKAGVA 497
Query: 530 ----------LQKIFQE-------MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDLLQK 569
LQ + + + Y+ D W++E + V ++G L VE L
Sbjct: 498 APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 557
Query: 570 HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAE 629
H + + + A ++ +D P RD + ++ Y +L
Sbjct: 558 HRGLH-------QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLN---S 607
Query: 630 RRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSG 689
+ARL L F +E W+ EKE+ D+ T++ + A E+
Sbjct: 608 SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 667
Query: 690 RSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQF 749
+ ++ G+ ++ E+H + ++ QW+ + QL + L+E + QF
Sbjct: 668 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 727
Query: 750 QADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQ 806
+D + + + + L+ S D + L++ +D E++ Y+ L L ++
Sbjct: 728 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 787
Query: 807 ASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQALQDTLALYKMFSEADACEL 863
A A+ Q P +RGRL + YK+V E+T + D C+L
Sbjct: 788 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT----------------VHKGDECQL 830
Query: 864 WIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE 923
P + +V+ E + + V NQ A++ +
Sbjct: 831 ------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLVPPPNQEAQEAV------- 869
Query: 924 KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD 983
++AQ L T W Q VD K S L+ Q+ + +SW + ++ +
Sbjct: 870 TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQLIRSWSLATFRTLKPEE- 921
Query: 984 LGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV 1043
+ L ++E ++++ P+ S
Sbjct: 922 -----------------QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 964
Query: 1044 WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA-----------SEDMPN 1092
++++ L++ E E S+ Q+ + +L D + L +T + +
Sbjct: 965 YQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 1021
Query: 1093 TLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWN 1152
+ E +K + E + + + +K+ + E T LR L+ L G
Sbjct: 1022 RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT------LRSELE-LTLG-- 1072
Query: 1153 ELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-MPTT---LEGAEAAI 1208
+L ++ L + +R T+ AE L E L + +P T LE +A++
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132
Query: 1209 KK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINSDRIQEKVDSIDDRHRKNR 1261
KK E T DA +++ E G RL + ++ +R +E+V + +R +
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1192
Query: 1262 ETASELLMRLKD-NRDLQKFLQDCQELSLWINE---KMLTAQDMSYDEARNLHSKWLKHQ 1317
L+ R L+ + + L W+ + + Q M +++ + + + Q
Sbjct: 1193 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1252
Query: 1318 AFMAELASN-----------KEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLE 1366
A + E+ + K++++ I+ +QL++ K + E V K+ E
Sbjct: 1253 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP--AKKPKVQSGSE 1310
Query: 1367 STTQTKAQ-RLFDANKAELFTQSCADLDKWLHGLE-----SQIQSDDYGKDLTSVNILLK 1420
S Q R + L +Q + + L +E ++ Q + + L V L+
Sbjct: 1311 SVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE 1370
Query: 1421 KQQML-------ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEP 1473
KQ+ L + Q E KE+++ + Q + + +E + D KR ++Q + +L +
Sbjct: 1371 KQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKR-SIQEELQQLRQS 1428
Query: 1474 LNERKHNLLASKEIHQFNR-DVEDEILWVGERMPLATSTDHG---HNLQTVQLLIKKNQT 1529
E + +R +E+EI V ++ AT G LQ ++ ++ +
Sbjct: 1429 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE-ATERQRGGAEGELQALRARAEEAEA 1487
Query: 1530 LQKEIQGHQPR----IDDIFERSQNIVTDSSS---LSAEAIRQRLADLKQLWGLLI--EE 1580
+++ Q R + D +R + + +S AEA R++ L+ L L + EE
Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1547
Query: 1581 TEKRHRRLE-EAHRAQQYYFDAAE--AEAWMSEQ-----ELYMMSEEKAKDEQSAVSMLK 1632
E+R R+ E E R Q + A+ AEA + + E E ++E AV+ L+
Sbjct: 1548 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607
Query: 1633 K---------------HQILEQAVEDY-------------AETVHQLSKTSRALVADSHP 1664
+ + E+ +E + AE V Q ++A
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667
Query: 1665 ESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSH 1724
E+ER + R+ K ++ ++LAE+ +L+++ +L + + ++ AE+E++
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQ---ELEKQRQLAEGTAQ----QRLAAEQELIRLRA 1720
Query: 1725 ELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLAD-----ELINSGHSDA-----A 1774
E Q + +L+E R+ Q+R + LA E++ + + A +
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 1775 TIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQ-DKHKKLPEELG 1833
T + K L EL + ++ A + E + A+E R + + + L E+L
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 1834 RDQNTVETLQRMHTTFE---HDIQALGTQVRQLQEDAA----RLQAAYAGDKAD------ 1880
+ R+ T E + +A ++R+L ED A RL+ A KAD
Sbjct: 1841 ----AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896
Query: 1881 DIQKRENEVLEAWKSLL-DACESRR------VRLVDTGDKFRFFSMVRDLMLWMEDVIRQ 1933
++K + LE K L+ D RR + L + +K +L L IR
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR---IRS 1953
Query: 1934 IEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL-----LARKHYASEEI 1988
A++ R EL + + AE + R ++ KSL AR+ A+ E
Sbjct: 1954 -NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAARQRKAALEE 2010
Query: 1989 KEKLLQLTEKRKEMIDKWE-DRWEWLRLILEVHQFSRDA-SVAEAWLLGQEPYLSSREIG 2046
E+L E+ + + ++ E + L+L E Q A A A+ + Q+ + +
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070
Query: 2047 QSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPS 2106
Q +++L EA ++A +E ER E + RRQ EE ER ++ S E
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAER----EAAQSRRQVEEAERLKQ--SAEEQ 2124
Query: 2107 TKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDT----------------SEM 2150
+ +A++ + + EQ + AEQ + R + D +++
Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184
Query: 2151 VNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQE---TPSAQMEGFLNRK 2207
T R +E+ + + + A AA ++ +E + QME K
Sbjct: 2185 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2244
Query: 2208 HEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTA---------ASGIPYHSEVPVSLK 2258
EA N+ R N + + + A+ A A+ + +E ++ +
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304
Query: 2259 EAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKD-DEEMNTWIQAISSAISSDKHEVSAST 2317
A+ E L K + RL E L Q K+ +E +Q ++ E +
Sbjct: 2305 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2364
Query: 2318 QSTPASSRAQTLPTS 2332
Q T + R + L S
Sbjct: 2365 QRTLEAERQRQLEMS 2379
Score = 103 bits (257), Expect = 2e-21
Identities = 324/1635 (19%), Positives = 647/1635 (39%), Gaps = 194/1635 (11%)
Query: 677 LSKHRAFEDEMSGRSGHFEQAIKEGEDMIA--EEHFGSEKIRERIIYIREQWANLEQLSA 734
+++ + + E+ G + E E ++A E + +R + + + LSA
Sbjct: 1023 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1082
Query: 735 IRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEY-STQSLVKKHKDVAEEI 793
I ++L+ SL+ + A+++ + LK + E +T++ +KK + AE
Sbjct: 1083 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA- 1141
Query: 794 ANYRPTLDTLHEQ-------ASALPQEHAESPDV-----RGRLSGIEERYKEVAELTRLR 841
+PT D L ++ L Q H E DV R R++ + ER++ V T +R
Sbjct: 1142 --QQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERWRERVAQLLERWQAVLAQTDVR 1198
Query: 842 KQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPE 897
++ L+ + + E AD W+ + + +Q L D + ++ + ++L E
Sbjct: 1199 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-LADSQAVREQLRQEQALLEE 1257
Query: 898 MNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRE--LVDRKKDALLSAL 955
+ +V + A+Q +++ E ++ + +L S ++ + + + +
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1317
Query: 956 SIQNYHLECNETKS----WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 1011
++ ++ E S +I E + +E + L A Q++ ER L +EA
Sbjct: 1318 DLRTHYSELTTLTSQYIKFISETLRRMEEEERL--------AEQQRAEERER-LAEVEAA 1368
Query: 1012 LSDLQKEAE---KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFL 1068
L ++ AE + +++ +A+ + R+ E EE + ++ S+ E +LQQ L
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE--ELQQ-L 1425
Query: 1069 RDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV 1128
R + + Q A E + Q E + + E + Q +R E
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485
Query: 1129 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQ 1188
+ AQ R R Q D E + + L S+ A + R+ ++A L +
Sbjct: 1486 EAQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEAEAAREKQRALQAL--E 1539
Query: 1189 EYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQE 1248
E L E L AE +++ ++ + A +++ R ++ +R
Sbjct: 1540 ELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1594
Query: 1249 KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-ELSLWINEKMLTAQDMSYDEAR 1307
S+ + H + E R + + ++ ++ + EL W + +EA
Sbjct: 1595 ---SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW---------QLKANEAL 1642
Query: 1308 NLH--SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTG--LHKMWE 1363
L ++ + Q +A+ + K+ K E E K E +AV + +L L K +
Sbjct: 1643 RLRLQAEEVAQQKSLAQAEAEKQ---KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Query: 1364 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1423
+ E T Q QRL A + EL A+ ++ + Q+ ++ + +K+Q
Sbjct: 1700 LAEGTAQ---QRL--AAEQELIRLR-AETEQGEQ--QRQLLEEELARLQREAAAATQKRQ 1751
Query: 1424 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT-KFMELLEPLN------- 1475
LE ++ + E+E L + +E +ST E +RL + +F EL E
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 1476 --ERKHNLL---ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL 1530
+R+ L A+++ + R + +++ +GE L T + + +K+ +
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---------IALKEKEAE 1862
Query: 1531 QKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL-------LIEETEK 1583
+ ++ + D+ F+R + + + ++ I +RLA L++ L+E+T +
Sbjct: 1863 NERLR--RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1918
Query: 1584 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-----EQSAVSMLKKHQILE 1638
+ R++EE A + F+ A A E EL + A+D EQ+ + ++ Q+
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAARQRQL-- 1975
Query: 1639 QAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERH 1698
A E+ + ++L A+ +R + + +V++L A +++ R E
Sbjct: 1976 -AAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESA 2033
Query: 1699 RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTV 1758
R QL +E E+ + Q+ + ++ + R + +
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE- 2092
Query: 1759 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA---- 1814
A+E +AA + E R Q AA+ +L K
Sbjct: 2093 ---AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149
Query: 1815 ----------KEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQ 1864
K+ +KHKK E+ R + VE + TT ++ Q L
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE---QELTTLRLQLEETDHQKNLLD 2206
Query: 1865 EDAARL--QAAYAGDKADDIQKR------ENEVLEAWKSLLDACESRRVRLVDTGDKFRF 1916
E+ RL +A A + +++ + E L K+ ++A E+R + L D + RF
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRF 2265
Query: 1917 FSMVRDLMLWM-EDVIR-QIEAQE--KPRDVSSVELLMNN---HQGIKAEIDARNDSFTT 1969
+ M + E+ R + AQE + R ++ +L + +K ++ A ++ T
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA--T 2323
Query: 1970 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2029
++ LL ++ E +E+ +L E +++M + + + + LE + + A
Sbjct: 2324 RLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 2030 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLEVR 2088
EA L SR ++ ++ ++ K+ E EK T + E++T ++ LE++
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQ 2437
Query: 2089 RQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD-- 2146
RQQ + + +R E ++ E E QQ +K Q+ + Q + ET
Sbjct: 2438 RQQSDHDAER---LREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLLQETQALQ 2492
Query: 2147 ---TSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPS------ 2197
SE + +R +E + + D AK AQ R Q+
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK----AQQLREEQQRQQQQMEQERQRL 2548
Query: 2198 -AQMEGFLNRKHEWE 2211
A ME R+HE E
Sbjct: 2549 VASMEEARRRQHEAE 2563
Score = 100 bits (250), Expect = 1e-20
Identities = 306/1580 (19%), Positives = 623/1580 (39%), Gaps = 215/1580 (13%)
Query: 713 EKIRERIIYIREQWANLEQLSAIRKKRLEEASL-LHQFQADADDIDAWMLDI-------- 763
E+ RER+ + E+W + + +R++ LE+ L ++ AD + AW+ D
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234
Query: 764 -LKIVSSSDVGHDEYSTQSL---VKKHKDVAEE-----------IANYRPTLDTLHEQAS 808
+ + S V Q+L +++H + EE I +Y L T Q
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1294
Query: 809 ALPQEHAESPDVRGRLSGIEERYKEV----AELTRLRKQALQDTLALYKMFSEADACELW 864
+ A+ P V+ + + Y ++ +ELT L Q + K SE L
Sbjct: 1295 PVASP-AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI-------KFISET----LR 1342
Query: 865 IDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS-- 922
E+E+ L Q E+ E L ++ E A A + A++L
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 923 ---EKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIE 979
E + AQQ K + + + + + + +A + A + Q E + + I E+ +V+
Sbjct: 1403 RREEAAVDAQQQKRSIQ--EELQQLRQSSEAEIQAKARQAEAAERSRLR--IEEEIRVVR 1458
Query: 980 STQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL-------QKEAEKLESEHPDQAQA 1032
+ A +R+ G E +L A+ A+ + Q+EAE+L + D++Q
Sbjct: 1459 LQLE---------ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
Query: 1033 -------ILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLD-----DFQSWLSR 1080
+ SR+ ++ E + L+ E +A + ++ LR + Q L
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1569
Query: 1081 TQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFL 1140
Q + +E + AEK +++ E ++R+ E Q Q +A+
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEE----HVAVAQLREEAERRAQQQAEAE---- 1621
Query: 1141 RQRLQALDTGWNELHKMWENRQN------LLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH 1194
+A + EL + W+ + N L ++ A Q+ L QAEA +E A
Sbjct: 1622 ----RAREEAERELER-WQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQKEE---AE 1670
Query: 1195 TEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSID 1254
E + E A++++E + + +++ A +RL ++ + R +
Sbjct: 1671 REARRRGKAEEQAVRQRE--LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET------ 1722
Query: 1255 DRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWIN------EKMLTAQDMSYDEARN 1308
++ + R+ E L RL+ R+ Q QEL + E +L ++ + +E+R+
Sbjct: 1723 EQGEQQRQLLEEELARLQ--REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 1309 LHSKW---LKHQAF----MAELASNKEWLDKIEKEGMQLISE-----KPETEAVVKEKLT 1356
K L+ +A +AE A+ L + K QL E + E E V+ EKL
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 1357 GLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVN 1416
+ + + +T+A+ +AE D+ + Q+ + D+
Sbjct: 1841 AIGEATRL-----KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895
Query: 1417 ILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNE 1476
L+K ++++E +K +E+ Q + + +E + K + + L +
Sbjct: 1896 AQLRKAS--DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1953
Query: 1477 RKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQG 1536
+ L SKE + + ++ ER +L + ++ + +E++
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 1537 HQPRIDD---IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHR 1593
+ ++++ + ER++ L+ EA ++RL ++ +++ E+ L++ +
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE---LQQTLQ 2070
Query: 1594 AQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVS---MLKKHQILEQAVEDYAETVHQ 1650
+Q D EA + + E + + E+ A +++ + L+Q+ E+ A+ Q
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130
Query: 1651 LSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLF--QLNREVD 1708
+ L E+E+ + R+++ ++ K A+ E+H+ F Q R+
Sbjct: 2131 AQAAAEKL----RKEAEQEAARRAQAEQAALRQKQAADAEM----EKHKKFAEQTLRQKA 2182
Query: 1709 DLEQWIA--EREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDT---VNHLAD 1763
+EQ + ++ H+ E + L+ E AR + +E + L+
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2242
Query: 1764 ELINSGHSDAATIAEWKDG----LNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFG 1819
+ A I KD L E + ++ + ++ A+ E + A+E
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302
Query: 1820 RIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKA 1879
+ + +K+ +E ++ +Q T + + + L Q QE A RLQ DK
Sbjct: 2303 QQRALAEKMLKE------KMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQE----DKE 2351
Query: 1880 DDIQKRENEVLEAWKSLLDACESRRVRLVDTGD--KFRFFSMVRDLMLWMEDVIR-QIEA 1936
Q+ E + ++ L+A R++ + + K R M R ED R + +A
Sbjct: 2352 QMAQQLAEET-QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2410
Query: 1937 QEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLT 1996
+E + EL + ++ + + + +E ++E + +L
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------QSDHDAERLREAIAEL- 2455
Query: 1997 EKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLI 2056
E+ KE K + + L+L E Q + + + Q+ +LS E + L+
Sbjct: 2456 EREKE---KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---------EKDSLL 2503
Query: 2057 KRHEAFEKSAATWDERFS-ALERLTTLELLEVRRQQE-EEERKRRPPSPEPSTKVSEEAE 2114
+R E+ A ++ F + + L + R+QQ+ E+ER+R S E + + EAE
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563
Query: 2115 -----SQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPS 2169
Q++ + ++ Q L AE+ + R+ E + E + A + +S + +
Sbjct: 2564 EGVRRKQEELQQLEQQRRQQEELLAEE-NQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2622
Query: 2170 PTSDRKAKTALPAQSAATLP 2189
+ + AL +A P
Sbjct: 2623 TKTLPNGRDALDGPAAEAEP 2642
Score = 100 bits (249), Expect = 2e-20
Identities = 307/1564 (19%), Positives = 623/1564 (39%), Gaps = 209/1564 (13%)
Query: 384 REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLAR--RFDRKAA-MRETWLSE 440
R G+ ++ + ER+ + + L +RQ +LEQL R R+ R++A WL +
Sbjct: 1166 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1225
Query: 441 NQRLVSQDNFG--FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKR 498
+R Q D AV ++ +A+ +I + E+V+ A++
Sbjct: 1226 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY---------- 1275
Query: 499 ITARKDNVIRLWEY--LLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 556
I A KD ++L Y LE + + ++ ++ G + + QE + + E+ L+ Y
Sbjct: 1276 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL--TTLTSQY 1333
Query: 557 GKHLL-GVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAH 615
K + + + ++ L E + ER+ V A+ +K E + Q R+
Sbjct: 1334 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1393
Query: 616 MEFCYQELCQ-------LAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGK 668
+ +E+ + ++R+ EE ++L + AE + R+ E S +
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SEAEIQAKARQAEAAERSRLRIE 1451
Query: 669 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG---SEKIRERI--IYIR 723
+ V+RL + A E + G G + E+ A++ +E++R ++ R
Sbjct: 1452 EEIRVVRL--QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
Query: 724 EQWANLEQLSAIR------KKRLEEASLLHQFQADADDIDAWM----LDILKIVSSSDVG 773
++ A +E S ++ +++ L + + A++ + + ++ + V +
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1569
Query: 774 HDEYSTQSLVKKHKDVAEEIANYRPTLDTLH-------EQASALPQEHAESPDVRGRLSG 826
+ L K AE+ A +L H E+A Q+ AE+ R
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629
Query: 827 IEERYK-EVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 885
ER++ + E RLR QA + +A K ++A+A + +KE+ + K E+
Sbjct: 1630 ELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQA 1683
Query: 886 VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 945
V Q E E Q + ++A + +E E QQ +L EL
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELAR 1738
Query: 946 RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL-----TG 1000
+++A +A + + LE K +R + +V+ +++ + + + + K G
Sbjct: 1739 LQREA--AAATQKRQELEAELAK--VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794
Query: 1001 MERDLVAIEAKLSDLQKEA--------EKLESEHPDQAQAILSRLAEISDVWE---EMKT 1049
R+L A+L L +EA E + + + + +LA I + E +
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1854
Query: 1050 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1109
LK +EA E +L++ D + FQ Q A D+ L + K ++
Sbjct: 1855 ALKEKEA---ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRK--ASDSELER 1908
Query: 1110 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH-KMWENRQNLLSQS 1168
+ E+ ++ R Q + + + L+ + G EL ++ R N
Sbjct: 1909 QKGLVEDTLRQRR---------QVEEEILALKASFEKAAAGKAELELELGRIRSNA---- 1955
Query: 1169 HAYQQFLRDTKQAEAFLNNQEYVLAHTE---------MPTTLEGAEAAIKKQEDFMTTMD 1219
+ LR +QAE Q + A E + +L E A ++++ + +
Sbjct: 1956 ---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV- 2011
Query: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1279
E++ A VE RRL S R + + + E A ++ K+ ++LQ+
Sbjct: 2012 ---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQ 2067
Query: 1280 FLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ 1339
LQ Q + +++ + + A ++ + A+ E +++++ +
Sbjct: 2068 TLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123
Query: 1340 LISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH-- 1397
+ + +A E L + +A R A +A L + AD + H
Sbjct: 2124 QAQARAQAQAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172
Query: 1398 -GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA-QALSQEGKSTDE 1455
++ Q ++LT++ + L++ ++Q + +E++ L+++A +A Q + +E
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEE---TDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229
Query: 1456 VDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH 1515
+ S R VQ + + L+ E ++ L ++ R +++E E+M + +
Sbjct: 2230 LFSVR--VQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMK-QVAEEAAR 2282
Query: 1516 NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA------------- 1562
Q + Q ++++ + + + + V +++ L AEA
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2342
Query: 1563 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1622
R+ D +Q+ L EET+ R L EA R +Q AEA + + MS +A+
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQL---EMSAEAERLKLRVAEMSRAQAR 2398
Query: 1623 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVD--KLY 1680
E+ A Q + E+ E +H+ ++ V + ++ I +QS D +L
Sbjct: 2399 AEEDA-------QRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQSDHDAERLR 2449
Query: 1681 AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDY--EHVTMLQ- 1737
+ +L E+ KL + +L QL E Q + + +++ + L Q + E ++LQ
Sbjct: 2450 EAIAELEREKE-KLQQEAKLLQLKSEE---MQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 1738 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1797
ERF I QE+ DE +A+ + E ++ R
Sbjct: 2506 ERF---------IEQEKAKLEQLFQDE-----------VAKAQQLREEQQRQQQQMEQER 2545
Query: 1798 TQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALG 1857
+++A+ E + H+A+E R Q++ ++L ++ + + E L + +Q L
Sbjct: 2546 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE---ELLAEENQRLREQLQLLE 2602
Query: 1858 TQVR 1861
Q R
Sbjct: 2603 EQHR 2606
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 400 bits (1029), Expect = e-111
Identities = 575/2475 (23%), Positives = 1020/2475 (41%), Gaps = 325/2475 (13%)
Query: 50 DEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMR 109
DER+ VQKKTFTKWVN HL + I+DLY DLRDG LI LLEVLSG+ LP+ KGRMR
Sbjct: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 233
Query: 110 IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDN 169
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGLIWTIIL FQI DI V +
Sbjct: 234 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 292
Query: 170 KEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSN 229
E +AK+ LLLW Q GY + NFT+SWRDG FNA+IH+H+P LID +K+ +
Sbjct: 293 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 351
Query: 230 AHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKR 289
NL AF++AE+ LG+T+LLDPED+ V PDEKSIITYV + Y ++ + +G R
Sbjct: 352 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 410
Query: 290 IGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRT 349
A E + ++Y L LL+W+ R+F +S ++ F ++
Sbjct: 411 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 463
Query: 350 VEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELA 409
+E P K +K + + +++ ++A KV G D+ K W +L A ERE
Sbjct: 464 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 520
Query: 410 LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIET 469
LR+E R E L+++ + +A + E L++ L+ D L A ++ +E
Sbjct: 521 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 577
Query: 470 DIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLG 529
D+ + ++ + + L+ + +++ R V RL E L+ + RL+ +
Sbjct: 578 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHERLVAIRTEYNLRLKAGVA 634
Query: 530 ----------LQKIFQE-------MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDLLQK 569
LQ + + + Y+ D W++E + V ++G L VE L
Sbjct: 635 APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 694
Query: 570 HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAE 629
H + + + A ++ +D P RD + ++ Y +L
Sbjct: 695 HRGLH-------QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLN---S 744
Query: 630 RRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSG 689
+ARL L F +E W+ EKE+ D+ T++ + A E+
Sbjct: 745 SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 804
Query: 690 RSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQF 749
+ ++ G+ ++ E+H + ++ QW+ + QL + L+E + QF
Sbjct: 805 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 864
Query: 750 QADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQ 806
+D + + + + L+ S D + L++ +D E++ Y+ L L ++
Sbjct: 865 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 924
Query: 807 ASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQALQDTLALYKMFSEADACEL 863
A A+ Q P +RGRL + YK+V E+T + D C+L
Sbjct: 925 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT----------------VHKGDECQL 967
Query: 864 WIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE 923
P + +V+ E + + V NQ A++ +
Sbjct: 968 ------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLVPPPNQEAQEAV------- 1006
Query: 924 KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD 983
++AQ L T W Q VD K S L+ Q+ + +SW + ++ +
Sbjct: 1007 TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQLIRSWSLATFRTLKPEE- 1058
Query: 984 LGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV 1043
+ L ++E ++++ P+ S
Sbjct: 1059 -----------------QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 1101
Query: 1044 WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA-----------SEDMPN 1092
++++ L++ E E S+ Q+ + +L D + L +T + +
Sbjct: 1102 YQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 1158
Query: 1093 TLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWN 1152
+ E +K + E + + + +K+ + E T LR L+ L G
Sbjct: 1159 RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT------LRSELE-LTLG-- 1209
Query: 1153 ELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-MPTT---LEGAEAAI 1208
+L ++ L + +R T+ AE L E L + +P T LE +A++
Sbjct: 1210 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1269
Query: 1209 KK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINSDRIQEKVDSIDDRHRKNR 1261
KK E T DA +++ E G RL + ++ +R +E+V + +R +
Sbjct: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1329
Query: 1262 ETASELLMRLKD-NRDLQKFLQDCQELSLWINE---KMLTAQDMSYDEARNLHSKWLKHQ 1317
L+ R L+ + + L W+ + + Q M +++ + + + Q
Sbjct: 1330 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1389
Query: 1318 AFMAELASN-----------KEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLE 1366
A + E+ + K++++ I+ +QL++ K + E V K+ E
Sbjct: 1390 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP--AKKPKVQSGSE 1447
Query: 1367 STTQTKAQ-RLFDANKAELFTQSCADLDKWLHGLE-----SQIQSDDYGKDLTSVNILLK 1420
S Q R + L +Q + + L +E ++ Q + + L V L+
Sbjct: 1448 SVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE 1507
Query: 1421 KQQML-------ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEP 1473
KQ+ L + Q E KE+++ + Q + + +E + D KR ++Q + +L +
Sbjct: 1508 KQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKR-SIQEELQQLRQS 1565
Query: 1474 LNERKHNLLASKEIHQFNR-DVEDEILWVGERMPLATSTDHG---HNLQTVQLLIKKNQT 1529
E + +R +E+EI V ++ AT G LQ ++ ++ +
Sbjct: 1566 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE-ATERQRGGAEGELQALRARAEEAEA 1624
Query: 1530 LQKEIQGHQPR----IDDIFERSQNIVTDSSS---LSAEAIRQRLADLKQLWGLLI--EE 1580
+++ Q R + D +R + + +S AEA R++ L+ L L + EE
Sbjct: 1625 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1684
Query: 1581 TEKRHRRLE-EAHRAQQYYFDAAE--AEAWMSEQ-----ELYMMSEEKAKDEQSAVSMLK 1632
E+R R+ E E R Q + A+ AEA + + E E ++E AV+ L+
Sbjct: 1685 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1744
Query: 1633 K---------------HQILEQAVEDY-------------AETVHQLSKTSRALVADSHP 1664
+ + E+ +E + AE V Q ++A
Sbjct: 1745 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1804
Query: 1665 ESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSH 1724
E+ER + R+ K ++ ++LAE+ +L+++ +L + + ++ AE+E++
Sbjct: 1805 EAEREARRRGKAEEQAVRQRELAEQ---ELEKQRQLAEGTAQ----QRLAAEQELIRLRA 1857
Query: 1725 ELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLAD-----ELINSGHSDA-----A 1774
E Q + +L+E R+ Q+R + LA E++ + + A +
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1917
Query: 1775 TIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQ-DKHKKLPEELG 1833
T + K L EL + ++ A + E + A+E R + + + L E+L
Sbjct: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977
Query: 1834 RDQNTVETLQRMHTTFE---HDIQALGTQVRQLQEDAA----RLQAAYAGDKAD------ 1880
+ R+ T E + +A ++R+L ED A RL+ A KAD
Sbjct: 1978 ----AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 2033
Query: 1881 DIQKRENEVLEAWKSLL-DACESRR------VRLVDTGDKFRFFSMVRDLMLWMEDVIRQ 1933
++K + LE K L+ D RR + L + +K +L L IR
Sbjct: 2034 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR---IRS 2090
Query: 1934 IEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL-----LARKHYASEEI 1988
A++ R EL + + AE + R ++ KSL AR+ A+ E
Sbjct: 2091 -NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAARQRKAALEE 2147
Query: 1989 KEKLLQLTEKRKEMIDKWE-DRWEWLRLILEVHQFSRDA-SVAEAWLLGQEPYLSSREIG 2046
E+L E+ + + ++ E + L+L E Q A A A+ + Q+ + +
Sbjct: 2148 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2207
Query: 2047 QSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPS 2106
Q +++L EA ++A +E ER E + RRQ EE ER ++ S E
Sbjct: 2208 QEQSVLDQLRGEAEAARRAAEEAEEARVQAER----EAAQSRRQVEEAERLKQ--SAEEQ 2261
Query: 2107 TKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDT----------------SEM 2150
+ +A++ + + EQ + AEQ + R + D +++
Sbjct: 2262 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2321
Query: 2151 VNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQE---TPSAQMEGFLNRK 2207
T R +E+ + + + A AA ++ +E + QME K
Sbjct: 2322 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2381
Query: 2208 HEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTA---------ASGIPYHSEVPVSLK 2258
EA N+ R N + + + A+ A A+ + +E ++ +
Sbjct: 2382 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2441
Query: 2259 EAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKD-DEEMNTWIQAISSAISSDKHEVSAST 2317
A+ E L K + RL E L Q K+ +E +Q ++ E +
Sbjct: 2442 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2501
Query: 2318 QSTPASSRAQTLPTS 2332
Q T + R + L S
Sbjct: 2502 QRTLEAERQRQLEMS 2516
Score = 103 bits (257), Expect = 2e-21
Identities = 324/1635 (19%), Positives = 647/1635 (39%), Gaps = 194/1635 (11%)
Query: 677 LSKHRAFEDEMSGRSGHFEQAIKEGEDMIA--EEHFGSEKIRERIIYIREQWANLEQLSA 734
+++ + + E+ G + E E ++A E + +R + + + LSA
Sbjct: 1160 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1219
Query: 735 IRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEY-STQSLVKKHKDVAEEI 793
I ++L+ SL+ + A+++ + LK + E +T++ +KK + AE
Sbjct: 1220 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA- 1278
Query: 794 ANYRPTLDTLHEQ-------ASALPQEHAESPDV-----RGRLSGIEERYKEVAELTRLR 841
+PT D L ++ L Q H E DV R R++ + ER++ V T +R
Sbjct: 1279 --QQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERWRERVAQLLERWQAVLAQTDVR 1335
Query: 842 KQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPE 897
++ L+ + + E AD W+ + + +Q L D + ++ + ++L E
Sbjct: 1336 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-LADSQAVREQLRQEQALLEE 1394
Query: 898 MNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRE--LVDRKKDALLSAL 955
+ +V + A+Q +++ E ++ + +L S ++ + + + +
Sbjct: 1395 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1454
Query: 956 SIQNYHLECNETKS----WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 1011
++ ++ E S +I E + +E + L A Q++ ER L +EA
Sbjct: 1455 DLRTHYSELTTLTSQYIKFISETLRRMEEEERL--------AEQQRAEERER-LAEVEAA 1505
Query: 1012 LSDLQKEAE---KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFL 1068
L ++ AE + +++ +A+ + R+ E EE + ++ S+ E +LQQ L
Sbjct: 1506 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE--ELQQ-L 1562
Query: 1069 RDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV 1128
R + + Q A E + Q E + + E + Q +R E
Sbjct: 1563 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1622
Query: 1129 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQ 1188
+ AQ R R Q D E + + L S+ A + R+ ++A L +
Sbjct: 1623 EAQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEAEAAREKQRALQAL--E 1676
Query: 1189 EYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQE 1248
E L E L AE +++ ++ + A +++ R ++ +R
Sbjct: 1677 ELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1731
Query: 1249 KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-ELSLWINEKMLTAQDMSYDEAR 1307
S+ + H + E R + + ++ ++ + EL W + +EA
Sbjct: 1732 ---SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW---------QLKANEAL 1779
Query: 1308 NLH--SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTG--LHKMWE 1363
L ++ + Q +A+ + K+ K E E K E +AV + +L L K +
Sbjct: 1780 RLRLQAEEVAQQKSLAQAEAEKQ---KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1836
Query: 1364 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1423
+ E T Q QRL A + EL A+ ++ + Q+ ++ + +K+Q
Sbjct: 1837 LAEGTAQ---QRL--AAEQELIRLR-AETEQGEQ--QRQLLEEELARLQREAAAATQKRQ 1888
Query: 1424 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT-KFMELLEPLN------- 1475
LE ++ + E+E L + +E +ST E +RL + +F EL E
Sbjct: 1889 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1948
Query: 1476 --ERKHNLL---ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL 1530
+R+ L A+++ + R + +++ +GE L T + + +K+ +
Sbjct: 1949 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---------IALKEKEAE 1999
Query: 1531 QKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL-------LIEETEK 1583
+ ++ + D+ F+R + + + ++ I +RLA L++ L+E+T +
Sbjct: 2000 NERLR--RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 2055
Query: 1584 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-----EQSAVSMLKKHQILE 1638
+ R++EE A + F+ A A E EL + A+D EQ+ + ++ Q+
Sbjct: 2056 QRRQVEEEILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAARQRQL-- 2112
Query: 1639 QAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERH 1698
A E+ + ++L A+ +R + + +V++L A +++ R E
Sbjct: 2113 -AAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESA 2170
Query: 1699 RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTV 1758
R QL +E E+ + Q+ + ++ + R + +
Sbjct: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE- 2229
Query: 1759 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA---- 1814
A+E +AA + E R Q AA+ +L K
Sbjct: 2230 ---AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2286
Query: 1815 ----------KEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQ 1864
K+ +KHKK E+ R + VE + TT ++ Q L
Sbjct: 2287 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE---QELTTLRLQLEETDHQKNLLD 2343
Query: 1865 EDAARL--QAAYAGDKADDIQKR------ENEVLEAWKSLLDACESRRVRLVDTGDKFRF 1916
E+ RL +A A + +++ + E L K+ ++A E+R + L D + RF
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRF 2402
Query: 1917 FSMVRDLMLWM-EDVIR-QIEAQE--KPRDVSSVELLMNN---HQGIKAEIDARNDSFTT 1969
+ M + E+ R + AQE + R ++ +L + +K ++ A ++ T
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA--T 2460
Query: 1970 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2029
++ LL ++ E +E+ +L E +++M + + + + LE + + A
Sbjct: 2461 RLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2517
Query: 2030 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLEVR 2088
EA L SR ++ ++ ++ K+ E EK T + E++T ++ LE++
Sbjct: 2518 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQ 2574
Query: 2089 RQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD-- 2146
RQQ + + +R E ++ E E QQ +K Q+ + Q + ET
Sbjct: 2575 RQQSDHDAER---LREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLLQETQALQ 2629
Query: 2147 ---TSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPS------ 2197
SE + +R +E + + D AK AQ R Q+
Sbjct: 2630 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK----AQQLREEQQRQQQQMEQERQRL 2685
Query: 2198 -AQMEGFLNRKHEWE 2211
A ME R+HE E
Sbjct: 2686 VASMEEARRRQHEAE 2700
Score = 100 bits (250), Expect = 1e-20
Identities = 306/1580 (19%), Positives = 623/1580 (39%), Gaps = 215/1580 (13%)
Query: 713 EKIRERIIYIREQWANLEQLSAIRKKRLEEASL-LHQFQADADDIDAWMLDI-------- 763
E+ RER+ + E+W + + +R++ LE+ L ++ AD + AW+ D
Sbjct: 1312 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1371
Query: 764 -LKIVSSSDVGHDEYSTQSL---VKKHKDVAEE-----------IANYRPTLDTLHEQAS 808
+ + S V Q+L +++H + EE I +Y L T Q
Sbjct: 1372 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1431
Query: 809 ALPQEHAESPDVRGRLSGIEERYKEV----AELTRLRKQALQDTLALYKMFSEADACELW 864
+ A+ P V+ + + Y ++ +ELT L Q + K SE L
Sbjct: 1432 PVASP-AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI-------KFISET----LR 1479
Query: 865 IDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS-- 922
E+E+ L Q E+ E L ++ E A A + A++L
Sbjct: 1480 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539
Query: 923 ---EKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIE 979
E + AQQ K + + + + + + +A + A + Q E + + I E+ +V+
Sbjct: 1540 RREEAAVDAQQQKRSIQ--EELQQLRQSSEAEIQAKARQAEAAERSRLR--IEEEIRVVR 1595
Query: 980 STQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL-------QKEAEKLESEHPDQAQA 1032
+ A +R+ G E +L A+ A+ + Q+EAE+L + D++Q
Sbjct: 1596 LQLE---------ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646
Query: 1033 -------ILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLD-----DFQSWLSR 1080
+ SR+ ++ E + L+ E +A + ++ LR + Q L
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1706
Query: 1081 TQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFL 1140
Q + +E + AEK +++ E ++R+ E Q Q +A+
Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEE----HVAVAQLREEAERRAQQQAEAE---- 1758
Query: 1141 RQRLQALDTGWNELHKMWENRQN------LLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH 1194
+A + EL + W+ + N L ++ A Q+ L QAEA +E A
Sbjct: 1759 ----RAREEAERELER-WQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQKEE---AE 1807
Query: 1195 TEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSID 1254
E + E A++++E + + +++ A +RL ++ + R +
Sbjct: 1808 REARRRGKAEEQAVRQRE--LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET------ 1859
Query: 1255 DRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWIN------EKMLTAQDMSYDEARN 1308
++ + R+ E L RL+ R+ Q QEL + E +L ++ + +E+R+
Sbjct: 1860 EQGEQQRQLLEEELARLQ--REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1917
Query: 1309 LHSKW---LKHQAF----MAELASNKEWLDKIEKEGMQLISE-----KPETEAVVKEKLT 1356
K L+ +A +AE A+ L + K QL E + E E V+ EKL
Sbjct: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977
Query: 1357 GLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVN 1416
+ + + +T+A+ +AE D+ + Q+ + D+
Sbjct: 1978 AIGEATRL-----KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 2032
Query: 1417 ILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNE 1476
L+K ++++E +K +E+ Q + + +E + K + + L +
Sbjct: 2033 AQLRKAS--DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 2090
Query: 1477 RKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQG 1536
+ L SKE + + ++ ER +L + ++ + +E++
Sbjct: 2091 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150
Query: 1537 HQPRIDD---IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHR 1593
+ ++++ + ER++ L+ EA ++RL ++ +++ E+ L++ +
Sbjct: 2151 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE---LQQTLQ 2207
Query: 1594 AQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVS---MLKKHQILEQAVEDYAETVHQ 1650
+Q D EA + + E + + E+ A +++ + L+Q+ E+ A+ Q
Sbjct: 2208 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2267
Query: 1651 LSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLF--QLNREVD 1708
+ L E+E+ + R+++ ++ K A+ E+H+ F Q R+
Sbjct: 2268 AQAAAEKL----RKEAEQEAARRAQAEQAALRQKQAADAEM----EKHKKFAEQTLRQKA 2319
Query: 1709 DLEQWIA--EREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDT---VNHLAD 1763
+EQ + ++ H+ E + L+ E AR + +E + L+
Sbjct: 2320 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2379
Query: 1764 ELINSGHSDAATIAEWKDG----LNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFG 1819
+ A I KD L E + ++ + ++ A+ E + A+E
Sbjct: 2380 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2439
Query: 1820 RIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKA 1879
+ + +K+ +E ++ +Q T + + + L Q QE A RLQ DK
Sbjct: 2440 QQRALAEKMLKE------KMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQE----DKE 2488
Query: 1880 DDIQKRENEVLEAWKSLLDACESRRVRLVDTGD--KFRFFSMVRDLMLWMEDVIR-QIEA 1936
Q+ E + ++ L+A R++ + + K R M R ED R + +A
Sbjct: 2489 QMAQQLAEET-QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2547
Query: 1937 QEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLT 1996
+E + EL + ++ + + + +E ++E + +L
Sbjct: 2548 EEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------QSDHDAERLREAIAEL- 2592
Query: 1997 EKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLI 2056
E+ KE K + + L+L E Q + + + Q+ +LS E + L+
Sbjct: 2593 EREKE---KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---------EKDSLL 2640
Query: 2057 KRHEAFEKSAATWDERFS-ALERLTTLELLEVRRQQE-EEERKRRPPSPEPSTKVSEEAE 2114
+R E+ A ++ F + + L + R+QQ+ E+ER+R S E + + EAE
Sbjct: 2641 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2700
Query: 2115 -----SQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPS 2169
Q++ + ++ Q L AE+ + R+ E + E + A + +S + +
Sbjct: 2701 EGVRRKQEELQQLEQQRRQQEELLAEE-NQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2759
Query: 2170 PTSDRKAKTALPAQSAATLP 2189
+ + AL +A P
Sbjct: 2760 TKTLPNGRDALDGPAAEAEP 2779
Score = 100 bits (249), Expect = 2e-20
Identities = 307/1564 (19%), Positives = 623/1564 (39%), Gaps = 209/1564 (13%)
Query: 384 REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLAR--RFDRKAA-MRETWLSE 440
R G+ ++ + ER+ + + L +RQ +LEQL R R+ R++A WL +
Sbjct: 1303 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1362
Query: 441 NQRLVSQDNFG--FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKR 498
+R Q D AV ++ +A+ +I + E+V+ A++
Sbjct: 1363 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY---------- 1412
Query: 499 ITARKDNVIRLWEY--LLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 556
I A KD ++L Y LE + + ++ ++ G + + QE + + E+ L+ Y
Sbjct: 1413 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL--TTLTSQY 1470
Query: 557 GKHLL-GVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAH 615
K + + + ++ L E + ER+ V A+ +K E + Q R+
Sbjct: 1471 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1530
Query: 616 MEFCYQELCQ-------LAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGK 668
+ +E+ + ++R+ EE ++L + AE + R+ E S +
Sbjct: 1531 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SEAEIQAKARQAEAAERSRLRIE 1588
Query: 669 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG---SEKIRERI--IYIR 723
+ V+RL + A E + G G + E+ A++ +E++R ++ R
Sbjct: 1589 EEIRVVRL--QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646
Query: 724 EQWANLEQLSAIR------KKRLEEASLLHQFQADADDIDAWM----LDILKIVSSSDVG 773
++ A +E S ++ +++ L + + A++ + + ++ + V +
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1706
Query: 774 HDEYSTQSLVKKHKDVAEEIANYRPTLDTLH-------EQASALPQEHAESPDVRGRLSG 826
+ L K AE+ A +L H E+A Q+ AE+ R
Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1766
Query: 827 IEERYK-EVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 885
ER++ + E RLR QA + +A K ++A+A + +KE+ + K E+
Sbjct: 1767 ELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQA 1820
Query: 886 VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 945
V Q E E Q + ++A + +E E QQ +L EL
Sbjct: 1821 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELAR 1875
Query: 946 RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL-----TG 1000
+++A +A + + LE K +R + +V+ +++ + + + + K G
Sbjct: 1876 LQREA--AAATQKRQELEAELAK--VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1931
Query: 1001 MERDLVAIEAKLSDLQKEA--------EKLESEHPDQAQAILSRLAEISDVWE---EMKT 1049
R+L A+L L +EA E + + + + +LA I + E +
Sbjct: 1932 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1991
Query: 1050 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1109
LK +EA E +L++ D + FQ Q A D+ L + K ++
Sbjct: 1992 ALKEKEA---ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRK--ASDSELER 2045
Query: 1110 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH-KMWENRQNLLSQS 1168
+ E+ ++ R Q + + + L+ + G EL ++ R N
Sbjct: 2046 QKGLVEDTLRQRR---------QVEEEILALKASFEKAAAGKAELELELGRIRSNA---- 2092
Query: 1169 HAYQQFLRDTKQAEAFLNNQEYVLAHTE---------MPTTLEGAEAAIKKQEDFMTTMD 1219
+ LR +QAE Q + A E + +L E A ++++ + +
Sbjct: 2093 ---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV- 2148
Query: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1279
E++ A VE RRL S R + + + E A ++ K+ ++LQ+
Sbjct: 2149 ---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQ 2204
Query: 1280 FLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ 1339
LQ Q + +++ + + A ++ + A+ E +++++ +
Sbjct: 2205 TLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260
Query: 1340 LISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH-- 1397
+ + +A E L + +A R A +A L + AD + H
Sbjct: 2261 QAQARAQAQAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2309
Query: 1398 -GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA-QALSQEGKSTDE 1455
++ Q ++LT++ + L++ ++Q + +E++ L+++A +A Q + +E
Sbjct: 2310 FAEQTLRQKAQVEQELTTLRLQLEE---TDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2366
Query: 1456 VDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH 1515
+ S R VQ + + L+ E ++ L ++ R +++E E+M + +
Sbjct: 2367 LFSVR--VQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMK-QVAEEAAR 2419
Query: 1516 NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA------------- 1562
Q + Q ++++ + + + + V +++ L AEA
Sbjct: 2420 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2479
Query: 1563 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1622
R+ D +Q+ L EET+ R L EA R +Q AEA + + MS +A+
Sbjct: 2480 ARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQL---EMSAEAERLKLRVAEMSRAQAR 2535
Query: 1623 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVD--KLY 1680
E+ A Q + E+ E +H+ ++ V + ++ I +QS D +L
Sbjct: 2536 AEEDA-------QRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQSDHDAERLR 2586
Query: 1681 AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDY--EHVTMLQ- 1737
+ +L E+ KL + +L QL E Q + + +++ + L Q + E ++LQ
Sbjct: 2587 EAIAELEREKE-KLQQEAKLLQLKSEE---MQTVQQEQLLQETQALQQSFLSEKDSLLQR 2642
Query: 1738 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1797
ERF I QE+ DE +A+ + E ++ R
Sbjct: 2643 ERF---------IEQEKAKLEQLFQDE-----------VAKAQQLREEQQRQQQQMEQER 2682
Query: 1798 TQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALG 1857
+++A+ E + H+A+E R Q++ ++L ++ + + E L + +Q L
Sbjct: 2683 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE---ELLAEENQRLREQLQLLE 2739
Query: 1858 TQVR 1861
Q R
Sbjct: 2740 EQHR 2743
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 361 bits (927), Expect = 4e-99
Identities = 417/1703 (24%), Positives = 728/1703 (42%), Gaps = 260/1703 (15%)
Query: 41 ERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERL 100
ER+ ++ +ADER+ VQKKTFTKWVN HL +V I DLY DLRDG LI LLEVLSG +L
Sbjct: 66 ERAVVR-VADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKL 124
Query: 101 PKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQ 160
P+ KGRMR H L+NV AL FLK+++V L N+ + DI DGN +LTLGLIWTIIL FQI
Sbjct: 125 PRE-KGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS 183
Query: 161 DISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLI 220
DI + E SAK+ LLLW Q TAGY + NF++ W DG FNALIH++RPDL+
Sbjct: 184 DIYISGESG--DMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLV 241
Query: 221 DFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKM 280
D ++++ + NL+ AF +AE+ LG+T+LLD ED+ V PDEKS+ITYV + Y F K+
Sbjct: 242 DMERVQIQSNRENLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKV 300
Query: 281 KALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQ 340
G+ I +A E + ++Y+S L+ WI+Q I+++++ F + V ++
Sbjct: 301 PE---GGEGI-----SATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKAL 352
Query: 341 LQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLE 400
+ ++ E K EKG +E L ++ + K+ +G +D+ + W +L
Sbjct: 353 YNQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKL---PQGYHPNDVEEEWGKLI 409
Query: 401 KAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAA 460
ERE +LR + R E L Q+A + A E L+ + + D A
Sbjct: 410 IEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQAD-------AAHLE 462
Query: 461 TKKHEAIETDIAAYEERVQAVVAVARE----LEAENYHDIKRITARKDNVIRLWEYLLEL 516
+ + E+D+ Y + + ++ + L ENY+ ++ + R V+RL + L+ L
Sbjct: 463 SGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFR---VMRLQDELVTL 519
Query: 517 LRARRQRLE-MNLGLQKIFQEMLYI-----------------------MDWM------DE 546
RLE NL + F + + W E
Sbjct: 520 ------RLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAE 573
Query: 547 MKVLVLSQDYG------KHLLGVEDLLQKHTLVE-----ADIGIQAERVRGVNASAQKFA 595
+ + S+D G + L VE++ K E + +Q E + ++ S ++
Sbjct: 574 LVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELG 633
Query: 596 TDGEGYKPCDPQVIR-------DRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMA 648
+ + + + ++ + + + +E Y C+L R+ + L KF
Sbjct: 634 SSVKEARLYEGKMSQNFHTSYAETLGKLETQY---CKLKETSSFRMRHLQSLHKFVSRAT 690
Query: 649 EEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEE 708
E W+ EKE+ + D+ + +++ + E+ + F E + E
Sbjct: 691 AELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLEN 750
Query: 709 HFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAW---MLDILK 765
H + + ++ Q ++QL ++ ++E + QF +DA +++++ + D +K
Sbjct: 751 HPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK 810
Query: 766 IVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLS 825
S D + L++ D E++ + ++ +L ++ + Q SPD
Sbjct: 811 RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPD------ 864
Query: 826 GIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 885
V + T + +A+ D + + D C L ++ Q I +
Sbjct: 865 -------HVLKNT-ISVKAVCDYRQIEITICKNDECVL--EDNSQRTKWKVISPTGNEAM 914
Query: 886 VIQHRFESLEPEMN--NQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFREL 943
V F P + ASRV Q L H H + K + W+ R+
Sbjct: 915 VPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSL--------ISWNYLRKD 966
Query: 944 VDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMER 1003
+D + L L + EC++ ++ + + QD + + +A + +L E
Sbjct: 967 LDLVQTWNLEKLR-SSAPGECHQIMKNLQAHYE--DFLQDSRDSVLFSVADRLRL---EE 1020
Query: 1004 DLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASK 1063
++ A +A+ L K E E + A+ +S L I EE + + R SL +
Sbjct: 1021 EVEACKARFQHLMKSMEN-EDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSR- 1078
Query: 1064 LQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRD 1123
D +W A+ + +T + ++L + + + + D++
Sbjct: 1079 --------TDRDAW---QDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSF--------- 1118
Query: 1124 MGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRD----TK 1179
+ Q + + LR L L + ++ + N L + ++D K
Sbjct: 1119 ----LHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVK 1174
Query: 1180 QAEAFLNNQEYVLAHTEMP----TTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRL 1235
E L+ +E VLA +TL + +K + + +D K V E RL
Sbjct: 1175 GYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRL 1234
Query: 1236 VSDGNINSDRIQEKVDSIDDR-HRKNRETASELLMRLKDNRDLQKFLQDCQ----ELSLW 1290
+ N++ +R QEK + +R HR ++L +R + +Q+ L D + L W
Sbjct: 1235 TPERNLDLERYQEKGSQLQERWHR----VIAQLEIRQSELESIQEVLGDYRACHGTLIKW 1290
Query: 1291 INEKMLTAQDM---SYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEG---------- 1337
I E + M +++R L + + A AE+ N+ LD+ +K
Sbjct: 1291 IEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDY 1350
Query: 1338 -MQLISEKPETEA----------------VVKEKLTGLHKMWEVLESTTQTKAQRLFDA- 1379
+QL++ K E+ + ++ L + L + T + + DA
Sbjct: 1351 ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDAL 1410
Query: 1380 -----------NKAELFTQSCADLDKWLHGLESQIQ---SDDYGKDLTSVNILLKKQQML 1425
+ + + +L W+ L Q + K+ T + + +QQ+L
Sbjct: 1411 RRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVL 1470
Query: 1426 ENQMEVRKKEIEELQSQAQA-LSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNL--- 1481
++ +K+++ E +Q L++ G E + K+++ E L LN+ H+L
Sbjct: 1471 SEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQIS------EQLNALNKAYHDLCDG 1524
Query: 1482 -------LASKEIHQ------------FNRDVEDEILWVGERMPLATSTDHGHNLQTVQL 1522
L S+ HQ ++ +ED WVG+ A + G Q
Sbjct: 1525 SANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQ-AERALAGHQGRTTQQDLS 1583
Query: 1523 LIKKNQTLQKEIQGHQPRIDDIFERSQNIVT-----------DSSSLSAE---AIRQRLA 1568
++KNQ+ K++Q DDI R+ + T + + LS A+R++L
Sbjct: 1584 ALQKNQSDLKDLQ------DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLH 1637
Query: 1569 DLKQLWGLLIEETEKRHRRLEEA 1591
K+ + L EET + LEEA
Sbjct: 1638 QAKEQYEALQEETRVAQKELEEA 1660
Score = 201 bits (511), Expect = 7e-51
Identities = 329/1647 (19%), Positives = 689/1647 (41%), Gaps = 112/1647 (6%)
Query: 494 HDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY-IMDWMDEMKVLVL 552
HD++ I AR W L + + R +L+ L FQ+ L ++ W+ + + L+
Sbjct: 3249 HDMEEINAR-------WNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIA 3301
Query: 553 SQDY-GKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRD 611
+Q V+ +Q+ L++ + + V + A + A E D + I
Sbjct: 3302 NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAE---LADREKITG 3358
Query: 612 RVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAE--EEGWIREKEKILSSDDYGKD 669
++ +E + EL AA R+ +LE+ L K F E AE + ++K+ +S+ G
Sbjct: 3359 QLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQ 3418
Query: 670 LTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMI-----AEEHFGSEKIRERIIYIRE 724
+ + + +H+A E+++ + QA+K G+ + AE+ SEKI ++
Sbjct: 3419 TAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDS----LQA 3474
Query: 725 QWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLV 783
+++ ++ + L++A S F D ++ W+ ++ +SS V ++ L
Sbjct: 3475 RYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFV--KDFKQDVLH 3532
Query: 784 KKHKD---VAEEIANYRPTLDTLHEQASALPQEHA--ESPDVRGRLSGIEERYKEVAELT 838
++H D + EEI N + +D + AL ++ E ++ +L GI+ RY ++ +
Sbjct: 3533 RQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTS 3592
Query: 839 RLRKQALQDTLALYKMF-SEADACELWIDEKEQWL--NNMQIPEKLEDLEVIQHRFESLE 895
+ L+ L F S + W+ E E+ L + Q P E + Q R + L+
Sbjct: 3593 SKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTG-EQIPQFQQRQKELK 3651
Query: 896 PEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKL----NTRWSQFRELVDRKKDAL 951
E+ + VN+++R L+ +E DKL N ++ + + ++ D +
Sbjct: 3652 KEVMEHRLVLDTVNEVSRALLELVPWRARE---GLDKLVSDANEQYKLVSDTIGQRVDEI 3708
Query: 952 LSALS-IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEA 1010
+A+ Q Y + +W+ E + + + + + A + D++ +
Sbjct: 3709 DAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKD 3768
Query: 1011 KLSDLQKEAEKLESEHPDQAQAILSRLAE-ISDVWEEMKTTLKNREASLGEASKL-QQFL 1068
+ +L ++ ++ + +L E + +E + R A L A L QF
Sbjct: 3769 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 3828
Query: 1069 RDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHEN---IKNEIDNYEEDYQKMRDMG 1125
++ W+ T+ IA +P+ + E+L Q E ++ I ++ K+ +G
Sbjct: 3829 ETYEELSPWIEETRALIAQ--LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIG 3886
Query: 1126 EMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTK---QAE 1182
+ + + M + ++ Q + + ++ + E RQ L+ A Q + T+ + E
Sbjct: 3887 PQLKELNPEEGEM-VEEKYQKAENMYAQIKE--EVRQRALALDEAVSQSTQITEFHDKIE 3943
Query: 1183 AFLNNQEYVLAHTEMPTTL----EGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLV-- 1236
L E + + MP + + I + ++ + A+ G L+
Sbjct: 3944 PMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGR 4003
Query: 1237 ---SDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDL-QKFLQDCQELSLWIN 1292
+D ++ + IQ+K+D + + A E ++ D +L +KF D L I
Sbjct: 4004 SQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIK 4063
Query: 1293 EKMLTAQDMSYD-EARNLHSKWLKHQAFMAELASNK-----EWLDKIEKEGMQLISEKPE 1346
+ QD+ +D E+ + +K Q AE + E L+ I G LI E
Sbjct: 4064 D----TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGE 4119
Query: 1347 TEAV-VKEKLTGLHKMWEVLESTTQTKAQRLFDANKAEL-FTQSCADLDKWLHGLESQIQ 1404
TE V++ + ++ WE L T + + ++L DA +A + + + + WL ++
Sbjct: 4120 TEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC 4179
Query: 1405 S-DDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTV 1463
+ G DL +V L + + + ++ ++ E+E+L Q + + + K+TDE D +
Sbjct: 4180 TMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK--KATDETDRDIIRE 4237
Query: 1464 Q-TKFMELLEPLNE----RKHNLL-ASKEIHQFNRDVEDEILWVGERMPLATSTDH-GHN 1516
T+ L E L E R+H L A + QF +E+ + W+ L + +
Sbjct: 4238 PLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGD 4297
Query: 1517 LQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL 1576
+ +++ + K+ L+ ++ HQ ++ + + ++ S+ A ++R RL + Q W
Sbjct: 4298 PKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWES 4357
Query: 1577 LIEETEKRHRRLEEA-HRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-EQSAVSMLKKH 1634
++++TE+R ++L+ +AQ ++ + + ++ E + + + ++A L H
Sbjct: 4358 VLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTH 4417
Query: 1635 QILEQAVEDYAETVHQLSKTSRALV--ADSHPESERISMRQSKVDKLYAGLKDLAEERRG 1692
L ++ ET +QL R ++ D + + +++ + + EER+
Sbjct: 4418 MELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKS 4477
Query: 1693 KLDERHRL-FQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQ-ERFREFARDTGNI 1750
KL+E L + + + W+ E + + Q E + FA + N
Sbjct: 4478 KLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEV-NA 4536
Query: 1751 GQERVDTVNHLADEL-INSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHK 1809
++++ ++ ++L S D I + W +++ R + L + + K
Sbjct: 4537 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 4596
Query: 1810 FYHDA-KEIFGRIQDKHKKLPEEL--GRDQNTVETLQRMHTTFEHDIQALGTQVRQLQED 1866
+H+A K++ ++D L EL D + ++ H F+ + LG + + + +
Sbjct: 4597 QFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQ---KTLGGK-QPVYDT 4652
Query: 1867 AARLQAAYAGDK--ADDIQKREN---EVLEAWKSLLDACESRRVRLVDT-GDKFRFFSMV 1920
R A +D QK +N EV + W ++ R+ +L + +F +
Sbjct: 4653 TIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDAL 4712
Query: 1921 RDLMLWMEDVIRQI-EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLA 1979
+ L+ W+ V Q+ E Q D+ V LM+ H+ + E+ R + G+ L+
Sbjct: 4713 QALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIE 4772
Query: 1980 RKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRD-ASVAEAWLLGQEP 2038
+ +K +L +L+ + + + L L+ + RD + WL E
Sbjct: 4773 NSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQ 4832
Query: 2039 YLSSR-EIGQSVDEVEKLIKRHEAFEK 2064
L R + + ++ LI H+ F K
Sbjct: 4833 TLRFRGALPDDTEALQSLIDTHKEFMK 4859
Score = 171 bits (434), Expect = 6e-42
Identities = 326/1760 (18%), Positives = 699/1760 (39%), Gaps = 173/1760 (9%)
Query: 306 KYESLASDLLEWIEQTIIILNNRKFANSLVGV-QQQLQAFNTYRTVEKPPKFTEKGNLEV 364
K++ LL W+ T ++ N+K ++ V + Q+Q + + K T
Sbjct: 3281 KFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATV------ 3334
Query: 365 LLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQ-- 422
++A ++ E ++D K +LE E L RQ++LE
Sbjct: 3335 ------DMLQAEGGRIAQSAE---LADREKITGQLESLESRWTELLSKAAARQKQLEDIL 3385
Query: 423 -LARRFDRKAAMRETWLSENQR-LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQA 480
LA++F A +LS ++ L + + G ++ +H+A+E DI + V
Sbjct: 3386 VLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3445
Query: 481 VVAVARELEAENYHDIKRITARK-DNVIRLWEYLLELLRARRQRLEMNLGLQKIF-QEML 538
V + + L + + + + K D++ + + + + L+ L ++F ++ +
Sbjct: 3446 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 3505
Query: 539 YIMDWMDEM------------KVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRG 586
+++W+ E+ K VL + + HL E+++ + V+ I
Sbjct: 3506 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIK-------- 3557
Query: 587 VNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWE 646
N A T GE + +I++++ ++ Y ++ +++ LE++R+L F
Sbjct: 3558 -NGQALLKQTTGE-----EVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQS 3611
Query: 647 MAEE-EGWIREKEKILSSD-----------DYGKDLTSVMRLLSKHRAFEDEMSGRSGHF 694
EE GW+RE E+ L++ + + + + + +HR D ++ S
Sbjct: 3612 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRAL 3671
Query: 695 EQAI----KEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA-SLLHQF 749
+ + +EG D + + EQ+ + R ++ A Q+
Sbjct: 3672 LELVPWRAREGLDKLVSD-------------ANEQYKLVSDTIGQRVDEIDAAIQRSQQY 3718
Query: 750 QADADDIDAWMLDI---LKIVSSSDVGHDEYSTQSLVKK--------HKDVAEEIANYRP 798
+ AD AW+ + L + + D+ + Q V+K HKD +E+ ++R
Sbjct: 3719 EQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRS 3778
Query: 799 TL-DTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 857
+ T E+ + QE ES + ++Y+ ++ L R L+ L F E
Sbjct: 3779 EIFGTCGEEQKTVLQEKTES---------LIQQYEAISLLNSERYARLERAQVLVNQFWE 3829
Query: 858 A-DACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQL 915
+ WI+E + + P E L Q L + + + +I QL
Sbjct: 3830 TYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQL 3889
Query: 916 MHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKT 975
+ ++ + K ++Q +E V ++ AL A+S E ++ + E
Sbjct: 3890 KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETL 3949
Query: 976 KVIESTQDLGNDLAGVMALQRKLTGMER----DLVAIEAKLSDLQKEAEKL--ESEHPDQ 1029
+ + S + + + R+ + +L ++ L++ E+L S+ D+
Sbjct: 3950 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4009
Query: 1030 ---AQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQTAI 1085
A+ I +L ++ WE++K + RE + +L ++F D+ + + TQ +
Sbjct: 4010 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4069
Query: 1086 ASEDMPNTLTEAEKLLTQH-ENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRL 1144
+ P K + E IK E D E+ + +R +G + + + +R+ +
Sbjct: 4070 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4129
Query: 1145 QALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEA-FLNNQEYVLAHTEMP---TT 1200
++ W L+K W+ R L + +DT QA +L+N V+ MP T
Sbjct: 4130 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNT--VIKLCTMPPVGTD 4187
Query: 1201 LEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDR--IQEKVDSIDDRHR 1258
L + + + ++F + + ++ + G ++ +DR I+E + +
Sbjct: 4188 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4247
Query: 1259 KNRETASELLMRLKDNR-DLQKFLQDCQELSLWIN--EKMLTAQDMSYDEARNLHSKWLK 1315
E + +L+ L +F +EL W+ E++L AQ + + + + K
Sbjct: 4248 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAK 4307
Query: 1316 HQAFMAELASNKEWLDKIEKEGMQLISEKPETEAV-VKEKLTGLHKMWE-VLESTTQTKA 1373
H ++ +++ ++ + K G +L+ +A ++ +L +++ WE VL+ T + +
Sbjct: 4308 HHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQ 4367
Query: 1374 QRLFDANKAELFTQSCADLDKWLHGLESQIQ-SDDYGKDLTSVNILLKKQQMLENQMEVR 1432
Q +A+ F D L +ESQ+ S G + L L +Q++ +
Sbjct: 4368 QLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAK 4427
Query: 1433 KKEIEELQSQAQAL---SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIH- 1488
++ +L + + + + S + + ++ K+ + + ERK L + +
Sbjct: 4428 EETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLAT 4487
Query: 1489 QFNRDVEDEILWVG-ERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFER 1547
+F +++ I W+ L ++ L TV I++++ E+ H+ +I ++ +
Sbjct: 4488 EFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQT 4547
Query: 1548 SQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAH-RAQQYYFDAAEAEA 1606
+ S I+ L ++ W +++ + +R R L++A RA+Q++ +
Sbjct: 4548 GNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLID 4607
Query: 1607 WMSEQELYMMSEEKAKDEQSAVSM-LKKHQILEQAVEDYAETVHQLSKTSRALVADSHPE 1665
W+ + E ++ SE + ++ + + L KH+ ++ + +T RAL E
Sbjct: 4608 WLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL-----KE 4662
Query: 1666 SERISMRQSKVDKLYAGLKDLAEERRGKLDER-HRLF-------QLNREVDDLEQWIAER 1717
+ K+D ++D + GK ER H+L Q + L W+ +
Sbjct: 4663 KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKV 4722
Query: 1718 EV-VAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHL---ADELINSGHSDA 1773
E +A + D + V L + + F ++ G +R TV L ELI + D
Sbjct: 4723 EPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG----KRTGTVQVLKRSGRELIENSRDDT 4778
Query: 1774 ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELG 1833
+ L+ W + +L ++ L + + + + D + + ++ G
Sbjct: 4779 TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRG 4838
Query: 1834 RDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDI----------Q 1883
+ E LQ + T + ++ + + + A + A D I +
Sbjct: 4839 ALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIR 4898
Query: 1884 KRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWM---EDVIRQIEAQEKP 1940
R EVL K E+ LV + ++ +L+ W+ E + Q + + P
Sbjct: 4899 ARFEEVLTWAKQHQQRLETALSELVANAE------LLEELLAWIQWAETTLIQRDQEPIP 4952
Query: 1941 RDVSSVELLMNNHQGIKAEI 1960
+++ V+ L+ HQ E+
Sbjct: 4953 QNIDRVKALIAEHQTFMEEM 4972
Score = 166 bits (421), Expect = 2e-40
Identities = 339/1898 (17%), Positives = 761/1898 (40%), Gaps = 230/1898 (12%)
Query: 357 TEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIR 416
+ KG+L + + Q + N +EGK S+I + K ER AL ++ R
Sbjct: 1867 SHKGDLRFVTISGQKVLDMENSF----KEGKEPSEIGNLVKDKLKDATERYTALHSKCTR 1922
Query: 417 Q-EKLEQLA---RRFDRKAAMRETWLSE---NQRLVSQDNFGFDLPAVEAATKKHEAIET 469
L L +F A + W+ N + D D ++ + ++
Sbjct: 1923 LGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQE 1982
Query: 470 DIAAYEERVQAVVAVAR---ELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEM 526
++A ++ V+ + VAR E+E E D + + D+++ ++ L L R L+
Sbjct: 1983 ELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQK 2042
Query: 527 NLGLQKIFQEMLY-IMDWMDEMKVLVLSQDYGKHLLGV-EDLLQKHTLVEADIGIQAERV 584
+ + QE L ++ + E++ + + GV ++ L + ++ DI Q +
Sbjct: 2043 AIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSL 2102
Query: 585 RGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFF 644
+F + V++ ++A + +++LC E+ + L++ + F
Sbjct: 2103 EATREMVTRFMETADSTTAA---VLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMF 2159
Query: 645 WEMAEE-EGWIREKEKILSSDDY-GKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGE 702
++ + + ++ K ++L+S + +D+T + + + ++ E + E
Sbjct: 2160 EHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTE-- 2217
Query: 703 DMIAEEHFGSE--KIRERIIYIREQWANLEQLSAIRKKRLEEAS-LLHQFQADADDIDAW 759
++ F + + ++R+ +R+ + L++ R+K L +F+ W
Sbjct: 2218 --LSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKW 2275
Query: 760 MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAE--S 817
+ + + ++ + ++ K + ++ A+ ++ ++ + ++L E +
Sbjct: 2276 LKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITA 2335
Query: 818 PDVRGR------------------------------LSGIEERYKEVAELTRLRKQALQD 847
PD +G+ +S + +Y+++ + R+++LQ
Sbjct: 2336 PDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQA 2395
Query: 848 TL-ALYKMFSEADACELWIDEKEQWLNNMQI---PEKLEDLEVIQHRFESLEPEMNNQAS 903
L + ++ EA++ W++ KE+ L +M P K E ++ ++ E+ +
Sbjct: 2396 ILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSP 2455
Query: 904 RVAVVNQIARQLMHSGHPSEKEI---KAQQDKLNTRWSQFREL-VDRKKDALLSALSIQN 959
++ V + L+ + +P+ +E K Q++LN+RW + E+ V R++ SA +
Sbjct: 2456 KIQKVKEALAGLLVT-YPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLAC 2514
Query: 960 YHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEA 1019
+ ++ + W+ EK ++ L D + A ++++ M ++ A + L + A
Sbjct: 2515 FQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAA 2574
Query: 1020 EKLESEHPD---QAQAILSRLAEISDVWEEMKTTLKNREASLGEA----SKLQQFLRDLD 1072
+ + + D + L I+ W E+ L +R + + +A ++ Q+ L+DL
Sbjct: 2575 QGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDL- 2633
Query: 1073 DFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQ 1132
S A+ L+ + TQ E +K +++ E + + V + Q
Sbjct: 2634 ------SEKVRAVGQR-----LSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQ 2682
Query: 1133 T---------DAQYMF--LRQRLQALDTGWNELHKMWENRQNLLSQSHAY-QQFLRDTKQ 1180
T QY+ L++RL+ + L + +R N L + A QQF + +
Sbjct: 2683 TLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDE 2742
Query: 1181 AEAFLNNQEYVLA-HTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDG 1239
+L++++ A + + LE ++ +++ E+F +++ + +V G L+
Sbjct: 2743 LRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV 2802
Query: 1240 NINSDR--IQEKVDSIDDRHRKNRETASELLMRLKD-NRDLQKFLQDCQELSLWINEKML 1296
++ +Q ++ + + + + ++ RLKD + QK+ ++L WI +
Sbjct: 2803 PPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKA 2862
Query: 1297 TAQDMSYD-EARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKL 1355
++ + L S L+ +A + E+ + L+ + LI+ E ++++
Sbjct: 2863 KMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEK 2922
Query: 1356 TGLHKMWEVLESTTQTKAQRLFD-ANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTS 1414
G+++ + + Q K L + + F +S +++K + G + Q++ D
Sbjct: 2923 AGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQAC 2982
Query: 1415 VNILLKKQQMLENQMEVRKKEIEELQSQAQALSQE---GKSTDEVDSKRLTVQTKFMELL 1471
N L+K + + ++ + +++ L++ Q L ++ G ++ + Q +F+E+
Sbjct: 2983 SNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVK 3042
Query: 1472 EPLNE----RKHNLLASKEIH-----QFNR--DVEDEILWVGERMPLATSTDHGHN-LQT 1519
+ +N ++ L + H F++ D++DE+ +G + TD + ++
Sbjct: 3043 QRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGA---IGRDTDSLQSQIED 3099
Query: 1520 VQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIE 1579
V+L + K L+ +I+ + + E + EA+ ++ L + E
Sbjct: 3100 VRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQE 3159
Query: 1580 ETEKRHRRLEEAHRAQQYYFDA------AEAEAWMSEQELYMMSEEKAKDEQSAVSMLKK 1633
+ E R+E+ +R + DA AEA W+ E+ +++++ A + +
Sbjct: 3160 QLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDP 3219
Query: 1634 HQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGK 1693
Q+ Q V + + Q + + H + E I+ R + ++K A +R +
Sbjct: 3220 LQMKLQQVNGLGQGLIQSAGKDCDVQGLEH-DMEEINARWNTLNKKVA-------QRIAQ 3271
Query: 1694 LDERHRLFQLNREVDDLE---QWIAE-REVVAGSHELGQDYEHVTMLQERFREFARDTGN 1749
L E L + D LE W+A+ E++A +Y+ V Q + ++ + +
Sbjct: 3272 LQEA--LLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYK-VVKAQIQEQKLLQRLLD 3328
Query: 1750 IGQERVDTVNHLADELINSGH-SDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELH 1808
+ VD + + S +D I + L W +LL R + L L
Sbjct: 3329 DRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLA 3388
Query: 1809 KFYHDAKEI---FGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQE 1865
K +H+ E F + +K E +G ++ H E DI+ T V Q +
Sbjct: 3389 KQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVK 3448
Query: 1866 DAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVR-DLM 1924
L + + + + ++ + + + + D C + L R F +++
Sbjct: 3449 IGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVL 3508
Query: 1925 LWM---EDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARK 1981
W+ ED + + ++ +DV + +H + EI R + I+ G++LL K
Sbjct: 3509 NWLAEVEDKLSSVFVKDFKQDV--LHRQHADHLALNEEIVNRKKNVDQAIKNGQALL--K 3564
Query: 1982 HYASEE---IKEKL-----------------LQLTEKRKEMIDKWEDRWE----WLRLIL 2017
EE I+EKL L+ E+ +++ K++ +E WLR +
Sbjct: 3565 QTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVE 3624
Query: 2018 E--------------------------------------VHQFSRDASVAEAWLLGQ--- 2036
E V++ SR W +
Sbjct: 3625 EELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLD 3684
Query: 2037 -------EPY-LSSREIGQSVDEVEKLIKRHEAFEKSA 2066
E Y L S IGQ VDE++ I+R + +E++A
Sbjct: 3685 KLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAA 3722
Score = 162 bits (409), Expect = 5e-39
Identities = 281/1475 (19%), Positives = 612/1475 (41%), Gaps = 101/1475 (6%)
Query: 722 IREQWANLEQLSAIRKKRLEEASLLH--QFQADADDIDAWMLDILKIVSSSDVGHDEYST 779
I +W L + A R +L+EA LLH +FQ + + +W+ D +++++ EY
Sbjct: 3254 INARWNTLNKKVAQRIAQLQEA-LLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV 3312
Query: 780 -QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ--EHAESPDVRGRLSGIEERYKEVAE 836
++ +++ K + + + + T+D L + + Q E A+ + G+L +E R+ E+
Sbjct: 3313 VKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLS 3372
Query: 837 LTRLRKQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQH--RFES 893
R++ L+D L L K F E A+ ++ E+ L N + P + ++ Q R ++
Sbjct: 3373 KAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSE-PVGTQTAKIQQQIIRHKA 3431
Query: 894 LEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ-DKLNTRWSQFRELVDRKKDALL 952
LE ++ N A+ V +I + L P+E+ + +++ D L R+S+ ++ RK L
Sbjct: 3432 LEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLD 3491
Query: 953 SALSIQNYHLECN-ETKSWIREKTKVIEST--QDLGNDLAGVMALQRKLTGMERDLVAIE 1009
ALS E E +W+ E + S +D D+ L D +A+
Sbjct: 3492 QALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDV---------LHRQHADHLALN 3542
Query: 1010 AKLSDLQKEAEK--------LESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEA 1061
++ + +K ++ L+ ++ I +L I + ++ T +L +A
Sbjct: 3543 EEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQA 3602
Query: 1062 SKLQ-QFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQK 1120
+L +F ++ WL + +A+ + E + Q + + E+ +++
Sbjct: 3603 RQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQ---IPQFQQRQKELKKEVMEHRL 3659
Query: 1121 MRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENR--QNLLSQSHAYQQFLRDT 1178
+ D V++ + R+ L L + NE +K+ + Q + A Q+ +
Sbjct: 3660 VLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE 3719
Query: 1179 KQAEAFL----NNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRR 1234
+ A+A L + ++A + + A ++ Q+ F + +++ ++ +
Sbjct: 3720 QAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSE 3779
Query: 1235 LVSD-GNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDL-QKFLQDCQELSLWIN 1292
+ G +QEK +S+ ++ SE RL+ + L +F + +ELS WI
Sbjct: 3780 IFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIE 3839
Query: 1293 E-KMLTAQDMSYD-EARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAV 1350
E + L AQ S + L + + + +A +K +DK+ K G QL PE +
Sbjct: 3840 ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM 3899
Query: 1351 VKEKLTGLHKMWEVLESTTQTKAQRLFDA-NKAELFTQSCADLDKWLHGLES-------- 1401
V+EK M+ ++ + +A L +A +++ T+ ++ L LE+
Sbjct: 3900 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 3959
Query: 1402 ---QIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDS 1458
+ D + ++ + + L+ E K+ EEL ++Q ++ + E+
Sbjct: 3960 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD-LAAKEIQD 4018
Query: 1459 KRLTVQTKFMELLEPLNERKHNLLASKEI-HQFNRDVEDEILWVGERMPLATSTDH-GHN 1516
K + + ++ ER+ L E+ +F D+ + + + + + G +
Sbjct: 4019 KLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGID 4078
Query: 1517 LQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL 1576
++ ++ +T+++E G ++ I +++ +R+ + ++ W
Sbjct: 4079 PSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWEN 4138
Query: 1577 LIEETEKRHRRLEEAHRAQQYYFDAAEAEA-WMSEQELYMMSEEKAKDEQSAVSMLKKHQ 1635
L + ++R +LE+A +A Y D +A W+ + + + + + V + ++
Sbjct: 4139 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKD-QLNE 4197
Query: 1636 ILEQAVEDYAETVH--QLSKTSRALVADSHPESERISMRQ--SKVDKLYAGLKDLAEERR 1691
+ E VE Y + + +L+ ++ + E++R +R+ +++ L+ L + R+
Sbjct: 4198 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4257
Query: 1692 GKLDERH-RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI 1750
KL+ L Q +++L W+ E + + V ++ ++
Sbjct: 4258 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA 4317
Query: 1751 GQERVDTVNHLADELI-NSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHK 1809
Q V+TVN +EL+ +S DA+++ + +N+ W +L+ + R Q L ++ + +
Sbjct: 4318 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4377
Query: 1810 FYHDAKEIF----GRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQE 1865
+H E F R++ + G + E L H ++A QL
Sbjct: 4378 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDT-HMELYSQLKAKEETYNQLL- 4435
Query: 1866 DAARLQAAYAGDKADDIQKRENEVL--EAWKSLLDACESRRVRLVDTGD-KFRFFSMVRD 1922
D RL D + ++ L + W + E R+ +L + + F + +++
Sbjct: 4436 DKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQE 4495
Query: 1923 LMLWMEDVIRQIEAQEKPRDVSSVELL-MNNHQGIKAEIDARNDSFTTCIELGKSLLARK 1981
+ W+ + + P + + L + H+ E++A D + G L K
Sbjct: 4496 FINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQL---K 4552
Query: 1982 HYASEE----IKEKLLQLTEKRKEMIDKWEDRWEWLRLILE-VHQFSRDASVAEAWLLGQ 2036
+ ++ IK L+ + + ++++ + +R L + QF WL
Sbjct: 4553 FLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDA 4612
Query: 2037 EPYLSSR-EIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEE 2095
E +L S EI D+++ + +H+ F+K+ + TT+ +
Sbjct: 4613 ESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYD-----TTI--------RTGRA 4659
Query: 2096 RKRRPPSPEPSTKVSE-EAESQQQWDTSKGEQVSQ 2129
K + PE S K+ E + +WDT G+ V +
Sbjct: 4660 LKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
Score = 154 bits (389), Expect = 1e-36
Identities = 310/1641 (18%), Positives = 660/1641 (40%), Gaps = 214/1641 (13%)
Query: 417 QEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEE 476
Q+ ++ A F E ++ ENQ +S + A +++EA++ + ++
Sbjct: 1596 QDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQK 1655
Query: 477 RVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQE 536
++ V A + E E K + K + L +++ + + Q L G++++
Sbjct: 1656 ELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA 1715
Query: 537 MLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEA---DIGIQAERVRGVNASAQK 593
L E L + Y E L ++ +++A ++ Q + SAQ
Sbjct: 1716 SL-------EKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQA 1768
Query: 594 FATD-GEGYKPCDPQVIRDRVAHMEFCYQ-ELCQLAAERRARLEESRRLWKFFWEMAEEE 651
F G P + Q+++ ++ ++ Y L Q AE + L KF + E E
Sbjct: 1769 FLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFE 1828
Query: 652 GWIREKEKILSS-DDYGKDLTSVMRLLSKHRAFEDEMSGRSG-------------HFEQA 697
W+ EK L + G ++ LL + +F +++ G E +
Sbjct: 1829 SWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENS 1888
Query: 698 IKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLL-------HQFQ 750
KEG++ + +K+++ E+ +A+ K S L HQFQ
Sbjct: 1889 FKEGKEPSEIGNLVKDKLKDA----------TERYTALHSKCTRLGSHLNMLLGQYHQFQ 1938
Query: 751 ADADDIDAWM----LDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQ 806
AD + AWM ++ K++S + V D Q + K + EE+A ++ ++ L +
Sbjct: 1939 NSADSLQAWMQACEANVEKLLSDT-VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKV 1997
Query: 807 ASALPQEHAE-SPD---VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEA-DAC 861
A + + E +PD V+ I ++ ++ R LQ +A + E+ ++
Sbjct: 1998 ARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESL 2057
Query: 862 ELWIDEKEQWLNNMQIPEKLEDLEVIQHRFES---LEPEMNNQASRVAVVNQIARQLMHS 918
I E EQ L Q+ VIQ + L+ ++ Q S + ++ + M +
Sbjct: 2058 LQSIGEVEQNLEGKQVSSLSSG--VIQEALATNMKLKQDIARQKSSLEATREMVTRFMET 2115
Query: 919 GHPSEKEIKAQQDKLNTRWSQFRELV--DRKKDALLSALSIQNYHLE--CNETKSWIREK 974
+ + Q KL +F +L ++K++ L L Q E + + ++ K
Sbjct: 2116 ADSTTAAV--LQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENK 2173
Query: 975 TKVIES----TQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLE-SEHPDQ 1029
++++ S QD+ + + L ++ + +L +E +++L L+ +H D+
Sbjct: 2174 SRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDR 2233
Query: 1030 AQAILSRLAEISDVWEEMKTTLKNREASLGEA-SKLQQFLRDLDDFQSWLSRTQTAIASE 1088
Q + + E++ T+K RE +L +F + + FQ WL T+ +I
Sbjct: 2234 VQ-------NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT 2286
Query: 1089 DMPNTLTEAEKLLTQHENIKNEIDNY-------EEDYQKMRDMGEMV-------TQGQTD 1134
+ + E EK Q E++K+ +D++ EE K + ++ +QG+T
Sbjct: 2287 ETSMSAKELEK---QIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTG 2343
Query: 1135 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQF---LRDTKQA-EAFLNNQEY 1190
+ + + +++ G++ + E + ++ + Y++ L + +++ +A LN E
Sbjct: 2344 SILPSVGSSVGSVN-GYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEE 2402
Query: 1191 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDA-----NEEKINAVVETGRRLVSDGNINSDR 1245
V H E + L+ E+ +E+ + +MDA E + A E+ + +++ NS +
Sbjct: 2403 V--HKEANSVLQWLES----KEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPK 2456
Query: 1246 IQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDE 1305
IQ K +E + LL+ ++++ + + + +EL N + A +++
Sbjct: 2457 IQ-----------KVKEALAGLLVTYPNSQEAENWKKIQEEL----NSRWERATEVTVAR 2501
Query: 1306 ARNLHSKWLKHQAFMAELASNKEWLDKIEKEGM------------QLISEKPETEAVVKE 1353
R L F A + + WL +EKE M L ++K + + ++KE
Sbjct: 2502 QRQLEESASHLACFQAAESQLRPWL--MEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKE 2559
Query: 1354 KLTGLHKMWEVLESTTQTKAQRLFDAN--------KAELFTQSCADLDKWLHGLESQIQS 1405
+ E L Q D + + + Q +L L+ SQI
Sbjct: 2560 -FEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ 2618
Query: 1406 ------------DDYGKDLTSVNILLKKQQMLENQMEVRKKEIE---ELQSQAQALSQEG 1450
D + + +V L Q + Q E K+++E E++S + L E
Sbjct: 2619 AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 2678
Query: 1451 KST----DEVD------------SKRLTVQTKFMELLEPLNERKHNLL--ASKEIHQFNR 1492
K DE+ KRL ++ LE L + N L A QF +
Sbjct: 2679 KEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ 2738
Query: 1493 DVEDEILWVGERM-PLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNI 1551
++ W+ ++ A + L+ +Q +++N+ QK + H + I +++
Sbjct: 2739 MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL 2798
Query: 1552 VTD-SSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA-HRAQQYYFDAAEAEAWMS 1609
+ ++ +L +LK W L ++T R RL++ +AQ+Y + + W+
Sbjct: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 2858
Query: 1610 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669
+ + M D S L + + + VE + L+ + L+ S + + I
Sbjct: 2859 DCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGI 2918
Query: 1670 SMRQSKVDKLYAGLKDLAEERRGKLDE---RHRLFQ-----LNREVDDLEQWIAEREVVA 1721
++ +++ + + + + G L+E R R FQ + ++V+ + + + +
Sbjct: 2919 RDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG 2978
Query: 1722 GSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSG--HSDAATIAEW 1779
++ E + QE + + +VD + + L+ SDA+ +
Sbjct: 2979 SQACSNKNLEKLRAQQEVLQAL--------EPQVDYLRNFTQGLVEDAPDGSDASQLLHQ 3030
Query: 1780 KDGLNEAWADLLELIDTRTQILAASYE-LHKFYHDAKEIFGRIQDKHKKLP--EELGRDQ 1836
+ + + ++ + +++ ++ E + +F+ +E+F ++ D +L +GRD
Sbjct: 3031 AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDT 3090
Query: 1837 NTVET--------LQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENE 1888
+++++ L ++H + DI+A + R + E+ L + + + K+ +
Sbjct: 3091 DSLQSQIEDVRLFLNKIH-VLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGK 3149
Query: 1889 VLEAWKSLLDACESRRVRLVD 1909
+ E K+ + E R+ D
Sbjct: 3150 LTERGKARQEQLELTLGRVED 3170
Score = 147 bits (371), Expect = 1e-34
Identities = 312/1712 (18%), Positives = 703/1712 (41%), Gaps = 146/1712 (8%)
Query: 389 ISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQD 448
+SD+N +E+L HER+ +L+ L R E++ + A + +E L + S
Sbjct: 2372 MSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2431
Query: 449 NFGFDLPAVEAATKKHEAIETDIAAYEERVQAV--------VAVARELEAENYHDIKRIT 500
V+A + ++A ++ ++Q V V EAEN+ I
Sbjct: 2432 K----TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKI---- 2483
Query: 501 ARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEM-LYIMDWMDEMKVLV-----LSQ 554
++ + WE E+ AR+++LE + FQ + W+ E ++++ LS
Sbjct: 2484 --QEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 2541
Query: 555 DYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVA 614
D ++L + + L E + + ++ +N +AQ T G G ++ +
Sbjct: 2542 D--PNMLNAQKQQVQFMLKEFE--ARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQ 2596
Query: 615 HMEFCYQELCQLAAERRARLEE----SRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDL 670
+ + EL R +++++ S + + +++E+ + ++ + S+ +
Sbjct: 2597 SINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSA------I 2650
Query: 671 TSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAE------EHFGSEKIRERIIYIRE 724
++ + + E+ + +KE + + E E + +++++R+ +
Sbjct: 2651 STQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVAL 2710
Query: 725 QWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAWMLD-ILKIVSSSDVGHDEYSTQSL 782
LE L+A R RL+ A + QFQ D++ W+ D + + + QS
Sbjct: 2711 PLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 2770
Query: 783 VKKHKDVAEEIANYRPTLDTLHEQASAL-----PQEHAESPDVRGRLSGIEERYKEVAEL 837
++++++ + + + + + + + +L P E E ++ +L ++ ++E+++
Sbjct: 2771 LQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGE--EKRTLQNQLVELKNHWEELSKK 2828
Query: 838 TRLRKQALQDTLALYKMFS-EADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEP 896
T R+ L+D + + + + WI++ + ++ +++ LE R +++
Sbjct: 2829 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 2888
Query: 897 EMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALS 956
E+ + S + ++N A L++S E I+ ++ +N E + K +L
Sbjct: 2889 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQ 2948
Query: 957 -IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL 1015
++ + + + +E LG+ L+ KL + L A+E ++ L
Sbjct: 2949 RLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLE-KLRAQQEVLQALEPQVDYL 3007
Query: 1016 QKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQ 1075
+ + L + PD + A S+L ++V ++ +K R S ++ L + F
Sbjct: 3008 RNFTQGLVEDAPDGSDA--SQLLHQAEVAQQEFLEVKQRVNS--GCVMMENKLEGIGQFH 3063
Query: 1076 SWLSRTQTAIASED-----MPNTLTEAEKLLTQHENIK---NEIDNYEEDYQKMRDMGEM 1127
+ + +A D M + + L +Q E+++ N+I + D +
Sbjct: 3064 CRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRH 3123
Query: 1128 VTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQS-HAYQQFLRDTKQAEAFLN 1186
+ + + + L++ L+AL+ +L + + RQ L + + F R K LN
Sbjct: 3124 MLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG----LN 3179
Query: 1187 NQEYVLAHTEMPTTLEGAEAAIKKQE--DF----MTTMDANEEKINAVVETGRRLVSDGN 1240
+ E + G E I Q+ DF +D + K+ V G+ L+
Sbjct: 3180 DATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAG 3239
Query: 1241 INSD--RIQEKVDSIDDR-HRKNRETASELLMRLKDNRDLQKFLQDCQELSLWI--NEKM 1295
+ D ++ ++ I+ R + N++ A + + KF + L W+ E++
Sbjct: 3240 KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEEL 3299
Query: 1296 LTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKL 1355
+ Q E + + ++ + + L K +D ++ EG ++ E +EK+
Sbjct: 3300 IANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQ---SAELADREKI 3356
Query: 1356 TG----LHKMWEVLESTTQTKAQRLFD-ANKAELFTQSCADLDKWLHGLESQI-QSDDYG 1409
TG L W L S + ++L D A+ F ++ + +L E ++ S+ G
Sbjct: 3357 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3416
Query: 1410 KDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALS------QEGKSTDEVDSKRLTV 1463
+ + + + LE +E ++ + Q+LS ++G ++++DS +
Sbjct: 3417 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDS----L 3472
Query: 1464 QTKFMELLEPLNERKHNLL--ASKEIHQFNRDVEDEILWVGE-RMPLATSTDHGHNLQTV 1520
Q ++ E+ + RK LL A F D + + W+ E L++ +
Sbjct: 3473 QARYSEIQDRCC-RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVL 3531
Query: 1521 QLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEE 1580
+ L +EI + +D + Q ++ ++ I+++L +K + +
Sbjct: 3532 HRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVT 3591
Query: 1581 TEKRHRRLEEAHR-AQQYYFDAAEAEAWMS--EQELYMMSEEKAKDEQSAVSMLKKHQIL 1637
+ K R LE+A + A ++ E W+ E+EL + EQ ++ ++
Sbjct: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELK 3651
Query: 1638 EQAVED--YAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLD 1695
++ +E +TV+++S+ LV E + S ++ Y + D +R ++D
Sbjct: 3652 KEVMEHRLVLDTVNEVSRALLELV--PWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 3709
Query: 1696 ERHRLFQLNREVDDLE-QWIAE--REVVA-GSHELGQDYEHVTMLQERFREFARDTGNIG 1751
+ Q + D E W+AE R+++A G L QD + LQ + + F+ D
Sbjct: 3710 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQD-QTTAQLQVQ-KAFSIDIIRHK 3767
Query: 1752 QERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR-TQILAASYELHKF 1810
+ +H ++ G + E + L + + + L R ++ A +++F
Sbjct: 3768 DSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQF 3827
Query: 1811 YHDAKEIFGRIQDKH---KKLP------EELGRDQNTVETLQRM---HTTFEHDIQALGT 1858
+ +E+ I++ +LP E+L + Q + L+ H + +G
Sbjct: 3828 WETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP 3887
Query: 1859 QVRQLQ-EDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFF 1917
Q+++L E+ ++ Y KA+++ + E + LD S+ ++ + DK
Sbjct: 3888 QLKELNPEEGEMVEEKY--QKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDK---- 3941
Query: 1918 SMVRDLMLWMEDVIRQIEAQEK-PRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKS 1976
+ ++ +E++ ++ P +V + +++++ E++ SF G+
Sbjct: 3942 --IEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEE 3999
Query: 1977 LLARKHYASEEIKEKLLQLTEKRKEMIDKWED 2008
L+ R A +++ K +Q +K +M+ WED
Sbjct: 4000 LIGRSQGADKDLAAKEIQ--DKLDQMVFFWED 4029
Score = 139 bits (350), Expect = 3e-32
Identities = 253/1432 (17%), Positives = 556/1432 (38%), Gaps = 148/1432 (10%)
Query: 290 IGKVLDNAIETEKMIEKYESLASDLLEWIEQT---IIILNNRKFANSLVGVQQQLQAFNT 346
IG+ +D + ++YE A L W+ +T ++ L + Q Q+Q +
Sbjct: 3701 IGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFS 3760
Query: 347 YRTVEKPPKFTEKGNLEVLLFTIQSKMRAN---NQKVYMPREGKLISDINKAWERLEKAE 403
+ E LF+ +S++ QK + + + + + +E +
Sbjct: 3761 IDIIRHKDSMDE-------LFSHRSEIFGTCGEEQKTVLQEKTE---SLIQQYEAISLLN 3810
Query: 404 HERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQ-DNFGFDLPAVEAATK 462
ER R E+ + L +F W+ E + L++Q + D + +
Sbjct: 3811 SER-------YARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQE 3863
Query: 463 KHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQ 522
+ + IA ++ + ++ + +L+ N + + + + ++ + E +R R
Sbjct: 3864 EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA- 3922
Query: 523 RLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLL-------------QK 569
L L + + I ++ D+++ ++ + + L + L+ K
Sbjct: 3923 -----LALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNK 3977
Query: 570 HTLVEADI---GIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQL 626
VE + +A + RG + D K + I+D++ M F ++++
Sbjct: 3978 SATVELEKLQPSFEALKRRGEELIGRSQGAD----KDLAAKEIQDKLDQMVFFWEDIKAR 4033
Query: 627 AAERRARLEESRRLWKFFW-EMAEEEGWIREKEKILSS-DDYGKDLTSVMRLLSKHRAFE 684
A ER + + L + FW +MA I++ + I+ + G D + + + + +
Sbjct: 4034 AEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIK 4093
Query: 685 DEMSGRSGHFEQAIKEGEDMI-AEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA 743
+E G E G D+I A ++R+ I + W NL + R ++LE+A
Sbjct: 4094 EETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDA 4153
Query: 744 -SLLHQFQADADDIDAWMLD-ILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLD 801
Q+Q + W+ + ++K+ + VG D + + + + K+ E+ + ++
Sbjct: 4154 MQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEME 4213
Query: 802 TLHEQASALPQEHAESPD---VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEA 858
L+ Q + ++ + D +R L+ ++ ++ + E R+ L+ L F A
Sbjct: 4214 KLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHA 4273
Query: 859 -DACELWIDEKEQWLNNMQI---PEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQ 914
+ W+ E+ L+ + K+ ++E+ +H L+ ++ + V VN+ +
Sbjct: 4274 LEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHV--LKNDVLAHQATVETVNKAGNE 4331
Query: 915 LMHSGHPSE-KEIKAQQDKLNTRWSQFRELVDRKKDALLSALS-IQNYHLECNETKSWIR 972
L+ S + ++++ + +N W + + ++ L S L Q +H +E + ++
Sbjct: 4332 LLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFH---SEIEDFLL 4388
Query: 973 EKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVA-IEAKLSDLQKEAEK-----LESEH 1026
E T++ ES G+ R+ +L + ++AK + +K L +
Sbjct: 4389 ELTRM-ESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDD 4447
Query: 1027 PDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQ-QFLRDLDDFQSWLSRTQTAI 1085
+A + W + + ++ R++ L EA L +F L +F +WL+ + ++
Sbjct: 4448 SGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSL 4507
Query: 1086 ASEDMPNT-LTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRL 1144
P+ L + +H+ NE++ + + ++ G + + ++ L
Sbjct: 4508 NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLL 4567
Query: 1145 QALDTGWNEL-HKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVL-AHTEMPTTLE 1202
++ + W ++ + E ++L +QF K+ +L + E L + E+ +
Sbjct: 4568 VSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPD 4627
Query: 1203 GAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSD---------RIQEKVDSI 1253
+ + K ++F T+ + + + TGR L + D +++K D++
Sbjct: 4628 KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTV 4687
Query: 1254 DDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKW 1313
+ + + E L+ D + L D L+ E L + + + +
Sbjct: 4688 CGKSVERQHKLEEALLFSGQFMDALQALVDW----LYKVEPQLAEDQPVHGDLDLVMNLM 4743
Query: 1314 LKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKA 1373
H+ F EL + +++ G +LI + VK +L L W+ + + +K
Sbjct: 4744 DAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQ 4803
Query: 1374 QRLFDANK-AELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVR 1432
RL A K AE+F + L +WL E ++ D T Q +++ E
Sbjct: 4804 SRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEA-----LQSLIDTHKEFM 4858
Query: 1433 KKEIEELQSQAQALSQEGK---------STDEVDSKRLTVQTKFMELLEPLNERKHNLLA 1483
KK +EE + + G+ + ++ +F E+L + + L
Sbjct: 4859 KK-VEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 4917
Query: 1484 SKEIHQFNRDVEDEIL----WVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQP 1539
+ N ++ +E+L W + N+ V+ LI ++QT +E+ QP
Sbjct: 4918 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 4977
Query: 1540 RIDDIFE--RSQNI----------------------------VTDSSSLSAEAIRQRLAD 1569
+D + + + +NI + S I Q A
Sbjct: 4978 DVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSAR 5037
Query: 1570 LKQLWGLLIEETEKRH---RRLEEAHRAQQYYFDAAEAE--AWMSEQELYMM 1616
+Q+W L +E K + RLEE + FD + WM+ ++ +M
Sbjct: 5038 WQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVM 5089
Score = 84.0 bits (206), Expect = 2e-15
Identities = 280/1545 (18%), Positives = 568/1545 (36%), Gaps = 239/1545 (15%)
Query: 540 IMDWMDEMKVLVLSQDYGKHLLGVEDLLQK----HTLVEADIGIQAERVRGVNAS-AQKF 594
++ W++EM++ + ++G L VE L+ HT VE ++G + R +Q F
Sbjct: 592 LLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE-ELGSSVKEARLYEGKMSQNF 650
Query: 595 ATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWI 654
T + + +E Y C+L R+ + L KF E W+
Sbjct: 651 HTS-----------YAETLGKLETQY---CKLKETSSFRMRHLQSLHKFVSRATAELIWL 696
Query: 655 REKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK 714
EKE+ + D+ + +++ + E+ + F E + E H +
Sbjct: 697 NEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQT 756
Query: 715 IRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWML---DILKIVSSSD 771
+ ++ Q ++QL ++ ++E + QF +DA ++++++ D +K S D
Sbjct: 757 VEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCD 816
Query: 772 VGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERY 831
+ L++ D E++ + ++ +L ++ + Q SPD
Sbjct: 817 HNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPD------------ 864
Query: 832 KEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF 891
V + T + +A+ D + + D C L ++ Q I + V F
Sbjct: 865 -HVLKNT-ISVKAVCDYRQIEITICKNDECVL--EDNSQRTKWKVISPTGNEAMVPSVCF 920
Query: 892 ESLEPEMN--NQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKD 949
P + ASRV Q L H H + K + + W+ R+ +D +
Sbjct: 921 LIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLIS--------WNYLRKDLDLVQT 972
Query: 950 ALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIE 1009
L L + EC++ ++ + + QD + + +A + +L E ++ A +
Sbjct: 973 WNLEKLR-SSAPGECHQIMKNLQAHYE--DFLQDSRDSVLFSVADRLRL---EEEVEACK 1026
Query: 1010 AKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLR 1069
A+ L K E E + A+ +S L I EE + + R SL +
Sbjct: 1027 ARFQHLMKSMEN-EDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRT------ 1079
Query: 1070 DLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVT 1129
D +W A+ + +T + ++L + + + + D++ +
Sbjct: 1080 ---DRDAW---QDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSF-------------LH 1120
Query: 1130 QGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDT----KQAEAFL 1185
Q + + LR L L + ++ + N L + ++D K E L
Sbjct: 1121 QSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKL 1180
Query: 1186 NNQEYVLAHTEMP----TTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNI 1241
+ +E VLA +TL + +K + + +D K V E RL + N+
Sbjct: 1181 SQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNL 1240
Query: 1242 NSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDM 1301
+ +R QEK + +R + ++L +R + +Q+ L D
Sbjct: 1241 DLERYQEKGSQLQERWHR---VIAQLEIRQSELESIQEVLGD------------------ 1279
Query: 1302 SYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKM 1361
Y KW++ E + +E + + E +++SE+ + + ++
Sbjct: 1280 -YRACHGTLIKWIE------ETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEI------ 1326
Query: 1362 WEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKK 1421
QTK ++ + F+Q + + K DY L + ++
Sbjct: 1327 -----ERNQTKL------DQCQKFSQQYSTIVK------------DYELQLMTYKAFVES 1363
Query: 1422 QQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNER--KH 1479
QQ + + S + A++QE + +T+ T+ ++ + R +
Sbjct: 1364 QQKSPGKRR-------RMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEE 1416
Query: 1480 NLLASKEIHQFNRDVEDEILWVG----ERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQ 1535
+ +E + V++ + WV ATS++ + ++ I + Q L +E+
Sbjct: 1417 EKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTD-IEKAILEQQVLSEELT 1475
Query: 1536 GHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQ 1595
+ ++ + + SQ + +E ++++++ +L ++A
Sbjct: 1476 TKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISE-----------------QLNALNKAY 1518
Query: 1596 QYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTS 1655
D + + + +L +E+K ++ K+ Q +ED V Q
Sbjct: 1519 HDLCDGSANQLQQLQSQLAHQTEQK--------TLQKQQNTCHQQLEDLCSWVGQ---AE 1567
Query: 1656 RALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIA 1715
RAL + S + K + LKDL + D ++R V D+E ++
Sbjct: 1568 RALAGH---QGRTTQQDLSALQKNQSDLKDLQD------DIQNRATSFATVVKDIEGFME 1618
Query: 1716 E-------REVVAGSHELGQDYEHVTMLQERFREFARD-----TGNIGQERVDTVNHLAD 1763
E RE+ A +L Q E LQE R ++ T + QE T A
Sbjct: 1619 ENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQE---TEKSKAA 1675
Query: 1764 ELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQD 1823
+ + + +W + + LL + Q+ AS E K D + + +
Sbjct: 1676 KELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE--KGALDTTDGYMGVNQ 1733
Query: 1824 KHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQ--LQEDAARLQAAYAGDKADD 1881
+KL ++ + + L F L TQ Q L + L ++
Sbjct: 1734 APEKLDKQCEMMKARHQELLSQQQNF-----ILATQSAQAFLDQHGHNLTP----EEQQM 1784
Query: 1882 IQKRENEVLEAWKSLLDACESRRVRLVDTGDKF-RFFSMVRDLMLWMEDVIRQIEAQEKP 1940
+Q++ E+ E + + L E+ ++ D+ +F ++ W+E +++E K
Sbjct: 1785 LQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKG 1844
Query: 1941 RDVSSVELLMNNHQGIKAE--IDARNDSFTTCIELGKSLLARKHYASEE---------IK 1989
+ QG +E I + D I G+ +L ++ E +K
Sbjct: 1845 GSSPETLPSLLKRQGSFSEDVISHKGDLRFVTIS-GQKVLDMENSFKEGKEPSEIGNLVK 1903
Query: 1990 EKLLQLTEKRKEMIDKWEDRWEWLRLIL-EVHQFSRDASVAEAWL 2033
+KL TE+ + K L ++L + HQF A +AW+
Sbjct: 1904 DKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWM 1948
Score = 53.9 bits (128), Expect = 2e-06
Identities = 74/402 (18%), Positives = 166/402 (41%), Gaps = 49/402 (12%)
Query: 1276 DLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEK 1335
D+ ++Q+C+ L + + +D +Y + L + ++ Q + L ++E
Sbjct: 472 DVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTL--------RLEC 523
Query: 1336 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLF--DANKAELFTQSCAD-- 1391
+ E V LT H E L T + + F +AEL S ++
Sbjct: 524 TNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDE 583
Query: 1392 --------LDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA 1443
L W+ ++ +++ ++G DL SV + L+ QQ + +E ++E +
Sbjct: 584 GNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYE 643
Query: 1444 QALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGE 1503
+SQ ++ +L +T++ +L E + R +L + +H+F E++W+ E
Sbjct: 644 GKMSQNFHTSYAETLGKL--ETQYCKLKETSSFRMRHL---QSLHKFVSRATAELIWLNE 698
Query: 1504 RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNI----------VT 1553
+ + D N + L E++ Q D+F Q+
Sbjct: 699 KEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQ----DVFRSLQDTAELLSLENHPAK 754
Query: 1554 DSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQEL 1613
+ + A++ +L +KQL L +E+ ++E Q++ DA E E+++ +
Sbjct: 755 QTVEAYSAAVQSQLQWMKQLC-LCVEQ------HVKENTAYFQFFSDARELESFLRNLQ- 806
Query: 1614 YMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTS 1655
+ + + D +++S L+ +L+ ++++ + + S +
Sbjct: 807 DSIKRKYSCDHNTSLSRLE--DLLQDSMDEKEQLIQSKSSVA 846
Score = 43.9 bits (102), Expect = 0.002
Identities = 48/248 (19%), Positives = 101/248 (40%), Gaps = 17/248 (6%)
Query: 1472 EPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQ 1531
+P+ + ++S E R V + + WV E + G++L +V+L ++ Q +
Sbjct: 567 KPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIH 626
Query: 1532 KEIQ--GHQPRIDDIFE--RSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRR 1587
++ G + ++E SQN T + + L L+ + L E + R R
Sbjct: 627 TSVEELGSSVKEARLYEGKMSQNFHTSYA--------ETLGKLETQYCKLKETSSFRMRH 678
Query: 1588 LEEAHRAQQYYFDAAEAEA-WMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAE 1646
L+ H+ + A AE W++E+E ++ + + + + + L +E+ +
Sbjct: 679 LQSLHK----FVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQD 734
Query: 1647 TVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNRE 1706
L T+ L ++HP + + + V +K L + E FQ +
Sbjct: 735 VFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSD 794
Query: 1707 VDDLEQWI 1714
+LE ++
Sbjct: 795 ARELESFL 802
Score = 33.5 bits (75), Expect = 2.5
Identities = 50/249 (20%), Positives = 93/249 (37%), Gaps = 34/249 (13%)
Query: 1878 KADDIQKRENEVLEAW-KSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEA 1936
KA+ + K + +W + + E + + RF V +L+ W+E++ ++E
Sbjct: 549 KAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRF---VYELLSWVEEMQMKLER 605
Query: 1937 QEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHY---ASEEIKEKLL 1993
E D+ SVEL + Q I ++ ELG S+ + Y S+
Sbjct: 606 AEWGNDLPSVELQLETQQHIHTSVE----------ELGSSVKEARLYEGKMSQNFHTSYA 655
Query: 1994 QLTEKRKEMIDKWEDRWEW-LRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQS-VDE 2051
+ K + K ++ + +R + +H+F A+ WL +E E+ D
Sbjct: 656 ETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKE----EEELAYDWSDN 711
Query: 2052 VEKLIKRHEAFEKSAATWDERFSALERL-TTLELLEVRRQQEEEERKRRPPSPEPSTKVS 2110
+ + F + +E+ L T ELL + P+ + S
Sbjct: 712 NSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENH----------PAKQTVEAYS 761
Query: 2111 EEAESQQQW 2119
+SQ QW
Sbjct: 762 AAVQSQLQW 770
>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
Length = 1369
Score = 338 bits (868), Expect = 3e-92
Identities = 329/1293 (25%), Positives = 558/1293 (43%), Gaps = 154/1293 (11%)
Query: 50 DEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMR 109
DER+ VQKKT TKWVN HL + I+DLY DLRDG LI LLEVLSG+ LP+ KGRMR
Sbjct: 171 DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 229
Query: 110 IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDN 169
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGLIWTIIL FQI DI V +
Sbjct: 230 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 288
Query: 170 KEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSN 229
E +AK+ LLLW Q GY + NFT+SWRDG FNA+IH+H+P LID +K+ +
Sbjct: 289 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 347
Query: 230 AHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKR 289
NL AF++AE+ LG+T+LLDPED+ V PDEKSIITYV + Y ++ + +G R
Sbjct: 348 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 406
Query: 290 IGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRT 349
A E + ++Y L LL+W+ R+F +S ++ F ++
Sbjct: 407 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 459
Query: 350 VEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELA 409
+E P K +K + + +++ ++A KV G D+ K W +L A ERE
Sbjct: 460 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 516
Query: 410 LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIET 469
LR+E R E L+++ + +A + E L + L+ D L A ++ +E
Sbjct: 517 LRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSD---IRLLAAGKVPQRAGEVER 573
Query: 470 DIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLG 529
D+ + ++ + + L+ + +++ R V RL E L+ + RL+ +
Sbjct: 574 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHERLVAIRTEYNLRLKAGVA 630
Query: 530 ----------LQKIFQE-------MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDLLQK 569
LQ + + + Y+ D W++E + V ++G L VE L
Sbjct: 631 APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 690
Query: 570 HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAE 629
H + + + A ++ +D P RD + ++ Y +L
Sbjct: 691 HRGLH-------QSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLN---S 740
Query: 630 RRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSG 689
+ARL L F +E W+ EKE+ D+ T++ + A E+
Sbjct: 741 SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 800
Query: 690 RSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQF 749
+ ++ G+ ++ E+H + ++ QW+ + QL + L+E + QF
Sbjct: 801 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 860
Query: 750 QADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQ 806
+D + + + + L+ +S D + L++ +D E++ Y+ L L ++
Sbjct: 861 FSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 920
Query: 807 ASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQALQDTLALYKMFSEADACEL 863
A A+ Q P +RGRL + YK+V E+T + D C+L
Sbjct: 921 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT----------------VHKGDECQL 963
Query: 864 WIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE 923
P + +V+ E + + V NQ ++ +
Sbjct: 964 ------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLVPPPNQEVQEAV------- 1002
Query: 924 KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD 983
++AQ L T W Q VD K S L+ Q+ + +SW + ++ +
Sbjct: 1003 TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQLIRSWSLATFRTLKPEE- 1054
Query: 984 LGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV 1043
+ L ++E ++++ P+ S
Sbjct: 1055 -----------------QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 1097
Query: 1044 WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA-----------SEDMPN 1092
++++ L++ E E S+ Q+ + +L D + L +T + +
Sbjct: 1098 YQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 1154
Query: 1093 TLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWN 1152
+ E +K + E + + + +K+ + E T LR L+ L G
Sbjct: 1155 RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT------LRSELE-LTLG-- 1205
Query: 1153 ELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-MPTT---LEGAEAAI 1208
+L ++ L + +R T+ AE L E L + +P T LE +A++
Sbjct: 1206 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1265
Query: 1209 KK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINSDRIQEKVDSIDDRHRKNR 1261
KK E T DA +++ E G RL + ++ +R +E+V + +R +
Sbjct: 1266 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1325
Query: 1262 ETASELLMRLKD-NRDLQKFLQDCQELSLWINE 1293
L+ R L+ + + L W+ +
Sbjct: 1326 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1358
Score = 57.4 bits (137), Expect = 2e-07
Identities = 185/927 (19%), Positives = 344/927 (37%), Gaps = 109/927 (11%)
Query: 1014 DLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDD 1073
D++KE KL AIL R ++ +E ++ + EA ++ L D
Sbjct: 498 DVEKEWGKLHV-------AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQAD- 549
Query: 1074 FQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQT 1133
+ L +A+ +P E E+ L + +++ + N D Q ++D G Q
Sbjct: 550 --ALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFN---DVQTLKD-GRHPQGEQM 603
Query: 1134 DAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA 1193
+ L +RL A+ T +N K Q R + ++ L + +LA
Sbjct: 604 YRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA 663
Query: 1194 HTEMPT-TLEGAE-----AAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQ 1247
E ++GAE +++ Q + + E+ A +E R +G ++
Sbjct: 664 WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS--DEGQLSPATRG 721
Query: 1248 EKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSY-DEA 1306
D + + + + RL+ L F+ + +W+NEK + D
Sbjct: 722 AYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRN 781
Query: 1307 RNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWE-VL 1365
N+ +K + A M EL ++ + +++ G +L+ E V+ L W +L
Sbjct: 782 TNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWML 841
Query: 1366 ESTTQTKAQRLFDANKAELFT---QSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQ 1422
+ +A +A + F+ ++ L K L + S D +T + LL+
Sbjct: 842 QLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK-NSCDRSATVTRLEDLLQDA 900
Query: 1423 QMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLL 1482
Q + Q+ K + L +A+A+ VQ K P+ R LL
Sbjct: 901 QDEKEQLNEYKGHLSGLAKRAKAV----------------VQLKPRHPAHPMRGRL-PLL 943
Query: 1483 ASKEIHQFNRDVE--DEILWVGERMP-----LATSTDHGHNLQTVQLLIKKNQTLQKEIQ 1535
A + Q V DE VG P L++S L+ NQ +Q+ +
Sbjct: 944 AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVT 1003
Query: 1536 GHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQ 1595
+ + + + D SL A +R L + W L T K + + H +
Sbjct: 1004 RLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE 1063
Query: 1596 QYY----FDAAEAEAWMSE----------------QELYMMSEEKAKDE---QSAVSMLK 1632
+Y D+ +A + E Q+L E+ A++E Q +S LK
Sbjct: 1064 LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 1123
Query: 1633 KHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRG 1692
++ +A E TVH+L L D P E + R ++ K A ++ L +
Sbjct: 1124 DIRLQLEACE--TRTVHRL-----RLPLDKEPARE-CAQRIAEQQKAQAEVEGLGKGVAR 1175
Query: 1693 KLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI-- 1750
E ++ L +E E+ G E V L + E + +
Sbjct: 1176 LSAEAEKVLALPEPSPAAPTLRSELELTLGK------LEQVRSLSAIYLEKLKTISLVIR 1229
Query: 1751 GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYE-LHK 1809
G + + V +E + + AT+ E EA L+ + + + +++ L
Sbjct: 1230 GTQGAEEVLRAHEEQLKEAQAVPATLPEL-----EATKASLKKLRAQAEAQQPTFDALRD 1284
Query: 1810 FYHDAKEIFGRIQDKHKKLPEELGR-DQNTVETLQRMHTTF------EHDIQALGTQVRQ 1862
A+E+ R+Q +H + E+ R + + L+R + +++ LG Q+R
Sbjct: 1285 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1344
Query: 1863 LQEDAARLQAAYAGDKADDIQKRENEV 1889
+E A L G D ++R+ ++
Sbjct: 1345 YRESADPL-----GAWLQDARRRQEQI 1366
Score = 44.3 bits (103), Expect = 0.001
Identities = 89/451 (19%), Positives = 182/451 (40%), Gaps = 58/451 (12%)
Query: 1569 DLKQLWGLL---IEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQ 1625
D+++ WG L I E EK+ R E Q + EA + E++L+ Q
Sbjct: 498 DVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALL----Q 553
Query: 1626 SAVSMLKKHQILEQAVE-----DYAETVHQLSKTSRALVADS-HPESERISMRQSKVD-- 1677
S + +L ++ ++A E D A+++ +L + D HP+ E++ R ++
Sbjct: 554 SDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHER 613
Query: 1678 ----------KLYAGLKDLAEE----------RRGKLDERHRLFQLNREVDDLEQWIAER 1717
+L AG+ A + RR +L++ R + DL W+ E
Sbjct: 614 LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELED-----STLRYLQDLLAWVEEN 668
Query: 1718 EVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIA 1777
+ E G D V R + Q +++ +DE G AT
Sbjct: 669 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-QAKIERAR--SDE----GQLSPATRG 721
Query: 1778 EWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELG---R 1834
++D L +L+++ L + LH F A + + +K + EE+G
Sbjct: 722 AYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE---EEVGFDWS 778
Query: 1835 DQNTVETLQR-MHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAW 1893
D+NT T ++ ++ +++ ++++LQ RL + ++ + + W
Sbjct: 779 DRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPT-VESFQAALQTQW 837
Query: 1894 KSLLDACESRRVRLVDTGDKFRFFSMVRDL---MLWMEDVIRQIEAQEKPRDVSSVELLM 1950
+L C L + F+FFS VR+ + +++ +R+ + ++ V+ +E L+
Sbjct: 838 SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLL 897
Query: 1951 NNHQGIKAEIDARNDSFTTCIELGKSLLARK 1981
+ Q K +++ + + K+++ K
Sbjct: 898 QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928
Score = 42.4 bits (98), Expect = 0.005
Identities = 151/753 (20%), Positives = 279/753 (37%), Gaps = 105/753 (13%)
Query: 1426 ENQMEVRKKEIEELQSQA--------QALSQEGK----STDEVDSKRLTVQTKFMELLEP 1473
E Q R+KE+EE+ + + L++ G +TDE D + TK++
Sbjct: 131 EEQRLYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKTSTKWVN---- 186
Query: 1474 LNERKHNLLASKEIHQFNRDVED--------EILWVGERMPLATSTDHGHNLQTVQLLIK 1525
KH + A + I D+ D E+L G+ +P H LQ VQ+ +
Sbjct: 187 ----KHLIKAQRHISDLYEDLRDGHNLISLLEVL-SGDSLPREKGRMRFHKLQNVQIAL- 240
Query: 1526 KNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRH 1585
+ ++++ R DDI + + + + + +++D+ Q+ G + T K
Sbjct: 241 -DYLRHRQVKLVNIRNDDIADGNPKLTL--GLIWTIILHFQISDI-QVSGQSEDMTAKEK 296
Query: 1586 RRLEEAHRAQQYYFDAAE--AEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVED 1643
L + Y + +W + L+ + K ++ + + LE +
Sbjct: 297 LLLWSQRMVEGYQGLRCDNFTSSWR-DGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQA 355
Query: 1644 YAETVHQLSKTSRALVADSHPESERISMRQSK-----VDKLYAGLKDLAEERRG-KLDER 1697
++ L T R L PE + K V LY + + + + G + +E
Sbjct: 356 FSVAERDLGVT-RLL----DPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410
Query: 1698 HRLFQLNRE-VDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFA------------ 1744
+Q RE V L QW+ +E + +L +F +F
Sbjct: 411 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
Query: 1745 RDTG---------NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNE-AWADLLELI 1794
R G GQ +V H D G A + K +E + L+ I
Sbjct: 471 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
Query: 1795 DTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQ 1854
T+ Q+ A E DA K+P+ G + ++ M +D+Q
Sbjct: 531 VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590
Query: 1855 ALGT----QVRQLQEDAARLQAAYAGDKAD-DIQKRENEVLEAWKSLLDACES--RRVRL 1907
L Q Q+ RL + + +++ + A + +S RR L
Sbjct: 591 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 650
Query: 1908 VDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSF 1967
D+ ++ ++DL+ W+E+ +++ E D+ SVE + +H+G+ I + F
Sbjct: 651 EDSTLRY-----LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSI----EEF 701
Query: 1968 TTCIELGKSLLARKHYASE-EIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDA 2026
IE +S + A+ ++ L +L + ++++ + R LR + +H F A
Sbjct: 702 QAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR---LRSLESLHSFVAAA 758
Query: 2027 SVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLE 2086
+ WL +E E+G + + E +SAL R L+ +
Sbjct: 759 TKELMWLNEKE----EEEVGFDWSD----------RNTNMTAKKESYSALMRELELKEKK 804
Query: 2087 VRRQQEEEERKRRPPSPEPSTKVSEEAESQQQW 2119
++ Q +R R P T S +A Q QW
Sbjct: 805 IKELQNAGDRLLREDHPARPTVESFQAALQTQW 837
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 310 bits (794), Expect = 1e-83
Identities = 186/411 (45%), Positives = 252/411 (61%), Gaps = 23/411 (5%)
Query: 48 LADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGR 107
+ADER+ VQKKTFTKW+N HL +V + DLY DLRDG LI LLEVLSG+ LP+ KGR
Sbjct: 58 IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGR 116
Query: 108 MRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETE 167
MR H L+NV AL +LK ++V L N+ + DI DGN +LTLGLIWTIIL FQI DI V E
Sbjct: 117 MRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 176
Query: 168 DNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKK 227
E SAK+ LLLW Q T GY + NFTT WRDG FNA+IHK+RPDLID + +
Sbjct: 177 S--EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 234
Query: 228 SNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEG 287
+ NL++AF +AE+ +G+ +LLDPED+ V PDEKS+ITYV + Y F K+ G
Sbjct: 235 QSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPE---GG 290
Query: 288 KRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTY 347
+ IG N +E K IE Y+++ + L++WI + ++ R F N+ V ++ + +
Sbjct: 291 EGIGA---NDVEV-KWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQF 345
Query: 348 RTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERE 407
+ E PPK TEK ++ L ++ + K+ +G +DI K W +L A ERE
Sbjct: 346 KETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLERE 402
Query: 408 LALRNELIRQEKLEQLARRFDRKAAMRETWL--------SENQRLVSQDNF 450
ALR E+ R E L+Q+A R R + + E L S+++RL S F
Sbjct: 403 KALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQF 453
Score = 232 bits (592), Expect = 3e-60
Identities = 340/1669 (20%), Positives = 714/1669 (42%), Gaps = 127/1669 (7%)
Query: 494 HDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY-IMDWMDEMKVLVL 552
HD+ + AR W+ L + + R +L+ L FQ+ L ++ WM + + LV
Sbjct: 3307 HDLDDVNAR-------WKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3359
Query: 553 SQDY-GKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRD 611
+Q V+ +Q+ L++ + + V + +K AT E P D I
Sbjct: 3360 NQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE---PADKVKILK 3416
Query: 612 RVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEE-EGWIREKEK-ILSSDDYGKD 669
+++ ++ ++ L A R +LE + + F E E W+ EK +++ + G
Sbjct: 3417 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3476
Query: 670 LTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDM-IAEEHFGSEKIRERIIYIREQWAN 728
+ + +++H+A ED++ + H QA+ G+ + + + ++ ++ + + +
Sbjct: 3477 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3536
Query: 729 LEQLSAIRKKRLEEASLLHQ-FQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHK 787
+++ S R + L++A + F D ++ W+ ++ +S V +YST+ L K+
Sbjct: 3537 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV--QDYSTEGLWKQQS 3594
Query: 788 DVA---EEIANYRPTLDTLHEQASALPQEHA--ESPDVRGRLSGIEERYKEVAELTRLRK 842
++ E+I + +D L ++ E ++ +L I+ RYK++ +L+
Sbjct: 3595 ELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVA 3654
Query: 843 QALQDTLALYK-MFSEADACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNN 900
+ L+ L L + + S + W+D+ E L + + K E+ Q R + L+ E N
Sbjct: 3655 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3714
Query: 901 QASRVAVVNQIARQLMHSGHPSEKE-IKAQQDKLNTRWSQFRELVDRKKDALLSA-LSIQ 958
+ + +N+++ L+ +E ++ + N R+ + + +K + + +A L Q
Sbjct: 3715 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQ 3774
Query: 959 NYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKE 1018
+ + SWI E K + S D+ + A + +++ + + DL K
Sbjct: 3775 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKS 3834
Query: 1019 AEKLESE-HPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQS 1076
K+ + ++ Q++ +L ++ ++ + R L A L QF ++
Sbjct: 3835 GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWP 3894
Query: 1077 WLSRTQTAIASEDMPNTLTEAEKLLTQ---HENIKNEIDNYEEDYQKMRDMGEMVTQGQT 1133
WL+ TQ+ I+ +P E E L Q H ++ I ++ KM G + + +
Sbjct: 3895 WLTETQSIISQ--LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE-LS 3951
Query: 1134 DAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA 1193
+ ++++ A DT ++++ + + R L ++ + D + + L + E ++
Sbjct: 3952 PGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILESLERIVE 4009
Query: 1194 HTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVET----GRRLVS-----DGNINSD 1244
P ++ IK+Q + + EK+ + ET G +++ D +I++
Sbjct: 4010 RLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 4069
Query: 1245 RIQEKVDSIDDRHRKNRETASELLMRLKDNRDL-QKFLQDCQELSLWINEKMLTAQDMSY 1303
+Q+K+D + E +L D +L +KF C +SL + K QD
Sbjct: 4070 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFW--CDHMSLIVTIK--DTQDFIR 4125
Query: 1304 D-EARNLHSKWLKHQAFMAELASNK-----EWLDKIEKEGMQLISEKPETEA-VVKEKLT 1356
D E + +K Q AE + E LD + G +LI+ E + +VK+ +
Sbjct: 4126 DLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSID 4185
Query: 1357 GLHKMWEVLESTTQTKAQRLFDANKAEL-FTQSCADLDKWLHGLESQIQS-DDYGKDLTS 1414
L+ W+ L + + +L +A +A + + + W+ ++ S G DL +
Sbjct: 4186 ELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLET 4245
Query: 1415 VNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELL--- 1471
V +++ + +++ ++ E+E L QA+ L + K T+E D TVQ MEL
Sbjct: 4246 VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK--KVTEESDKH--TVQDPLMELKLIW 4301
Query: 1472 ----EPLNERKHNLL-ASKEIHQFNRDVEDEILWVGERMPLATSTDH-GHNLQTVQLLIK 1525
E + R+H L A + QF +++ + W+ L + G + + +++ +
Sbjct: 4302 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4361
Query: 1526 KNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRH 1585
K+ LQ ++ HQ ++ + + +++ S+ A ++ +L L Q W ++E+TE+R
Sbjct: 4362 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4421
Query: 1586 RRLEEAHR-AQQYYFDAAEAEAWMSEQELYMMSEEKAKD-EQSAVSMLKKHQILEQAVED 1643
++L+ A R A+ ++ + + + W+++ E ++++ + ++A L H + A E
Sbjct: 4422 QQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4481
Query: 1644 YAETVHQLSKTSRALVADSHPESE-RISMRQSKVDKLYAGLKDLAEERRGKLDERHRL-F 1701
ET L + + ++A +E I + + + + ++ ER+ KL+E L
Sbjct: 4482 KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4541
Query: 1702 QLNREVDDLEQWIAEREV---VAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVD-- 1756
+ + + D W+ + E VA L D V + + FA + + ++ ++
Sbjct: 4542 EFHNSLQDFINWLTQAEQTLNVASRPSLILD--TVLFQIDEHKVFANEVNSHREQIIELD 4599
Query: 1757 -TVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA- 1814
T HL S D I + W +++ + R + L + + K +H+A
Sbjct: 4600 KTGTHLK---YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAW 4656
Query: 1815 KEIFGRIQDKHKKLPEEL--GRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL-- 1870
++ +++ K L EL D + ++T H F+ + A + L
Sbjct: 4657 SKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4716
Query: 1871 QAAYAGD--KADDIQKRENEVLEAWKSLLDACESRRVRLVDT-GDKFRFFSMVRDLMLWM 1927
+ + A D K DD+ +E+ + W ++ R+ +L + +F ++ L+ W+
Sbjct: 4717 KTSLADDNLKLDDML---SELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWL 4773
Query: 1928 EDVIRQI-EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASE 1986
V Q+ E Q D+ V L++NH+ + E+ R S + L+ S
Sbjct: 4774 YRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS 4833
Query: 1987 EIKEKLLQLTEKRKEMIDKWEDRWEWL---------RLILEVHQFSRDASVAEA---WLL 2034
+K ++ +L+ RWE + RL + Q SV A WL
Sbjct: 4834 WVKVQMQELS-----------TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLA 4882
Query: 2035 GQEPYLSSREI-GQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTL 2082
E L + D + LI +H+ F K +E+ + L + TT+
Sbjct: 4883 EAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL---EEKRAELNKATTM 4928
Score = 214 bits (546), Expect = 6e-55
Identities = 360/1876 (19%), Positives = 770/1876 (41%), Gaps = 157/1876 (8%)
Query: 288 KRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVG--------VQQ 339
K+ K+LD A E+ +E + +++ I+L + G + Q
Sbjct: 3203 KQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQ 3262
Query: 340 QLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERL 399
QL F ++ E P +G + + + Q +++ + + D+N W+ L
Sbjct: 3263 QLNMFKVFQKEEIEPL---QGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3319
Query: 400 EKAEHERELALRNELIR----QEKLEQLARRFDRKAAMRETWLSENQRLV-SQDNFGFDL 454
K +R L+ L+ Q+ LE L +W+ + + LV +Q +
Sbjct: 3320 NKKVAQRAAQLQEALLHCGRFQDALESLL-----------SWMVDTEELVANQKPPSAEF 3368
Query: 455 PAVEAATKKHEAIETDIAAYEERVQAVVAVARELE-----AENYHDIKRITARKDNVIRL 509
V+A ++ + ++ ++R V + RE E AE +K I + +
Sbjct: 3369 KVVKAQIQEQKLLQ---RLLDDRKSTVEVIKREGEKIATTAEPADKVK-ILKQLSLLDSR 3424
Query: 510 WEYLLELLRARRQRLE-MNLGLQKIFQEMLYIMDWMDEM-KVLVLSQDYGKHLLGVEDLL 567
WE LL R ++LE +++ Q+ + + + +W+ + K LV + G +E+ +
Sbjct: 3425 WEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQI 3484
Query: 568 QKHTLVEADIGIQAERVRGVNASAQ--KFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ 625
+H +E DI + + + Q K + E D +++ ++ + Y E+ +
Sbjct: 3485 AQHKALEDDIINHNKHLHQAVSIGQSLKVLSSRE-----DKDMVQSKLDFSQVWYIEIQE 3539
Query: 626 LAAERRARLEESRRLWKFFWE-MAEEEGWIRE---KEKILSSDDYGKDLTSVMRLLSKHR 681
+ R L+++ K F E E W+ E K LS DY + + + S+ R
Sbjct: 3540 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE--GLWKQQSELR 3597
Query: 682 AFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK--IRERIIYIREQWANLEQLSAIRKKR 739
++++ R + +QA+ G +++ ++ G E I++++ I+ ++ ++ +LS K
Sbjct: 3598 VLQEDILLRKQNVDQALLNGLELL-KQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3656
Query: 740 LEEA-SLLHQFQADADDIDAWM--LDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANY 796
LE+A L + + +++ W+ +++ + + V E ++Q+ ++ K++ +E N
Sbjct: 3657 LEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRP-KELKKEAKNN 3715
Query: 797 RPTLDTLHEQASAL----PQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALY 852
+ LD+L+E +SAL P E + ++ ERY+ V++ + + + +
Sbjct: 3716 KALLDSLNEVSSALLELVPWRAREG--LEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3773
Query: 853 KMFSEADACEL-WIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQI 911
+ F +A EL WI E E+ L + L D+ + Q + + + I
Sbjct: 3774 QQFDQAADAELSWITETEKKLMS------LGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3827
Query: 912 ARQLMHSGHP-----SEKE---IKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLE 963
L+ SGH SE+E +K + DK+ + ++ + L A S+ N E
Sbjct: 3828 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3887
Query: 964 C-NETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL 1022
E W+ E +I + + Q + + + + + + K +L
Sbjct: 3888 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3947
Query: 1023 ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEA-SKLQQFLRDLDDFQSWLSRT 1081
P + +I + ++ ++K +K R +L EA S+ QF +D L R
Sbjct: 3948 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4007
Query: 1082 QTAIASEDMPNTLTEAEKL---LTQHENIKNEIDNYEEDYQKMRDMGE--MVTQGQTDAQ 1136
+ P+ E EK+ +++++N+ +++ + Y+ ++ GE + G TD
Sbjct: 4008 VERL--RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4065
Query: 1137 Y--MFLRQRLQALDTGWNELHKMWENRQ-NLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA 1193
++ +L + W +H + E R+ LL ++F D + + + +
Sbjct: 4066 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIR 4125
Query: 1194 HTEMPTTLEGAEAAIKKQ-----EDFMTTMDANEEKINAVVETGRRLVSD-GNINSDRIQ 1247
E P G + ++ KQ E +D +E+++ V+ G L++ G + ++
Sbjct: 4126 DLEDP----GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4181
Query: 1248 EKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQD-CQELSLWIN---EKMLTAQDMSY 1303
+ +D ++ + + + +L++ QD Q + W++ K+ + +
Sbjct: 4182 KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT 4241
Query: 1304 DEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPE--TEAVVKEKLTGLHKM 1361
D + + + + F +E + ++++ + L+ + E + V++ L L +
Sbjct: 4242 D-LETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4300
Query: 1362 WEVLESTTQTKAQRLFDANKA-ELFTQSCADLDKWLHGLESQI-QSDDYGKDLTSVNILL 1419
W+ LE + +L A A F + +L WL E + + G D ++ I L
Sbjct: 4301 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIEL 4360
Query: 1420 KKQQMLENQMEVRKKEIEELQSQAQAL--SQEGKSTDEVDSKRLTVQTKFMELLEPLNER 1477
K +L+N + + +E + L S G+ + +K + ++ +LE +R
Sbjct: 4361 AKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQR 4420
Query: 1478 KHNL-LASKEIHQFNRDVEDEILWVGE-RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQ 1535
K L A ++ F+ ++ED W+ + L S G +T + + + + +
Sbjct: 4421 KQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFE 4480
Query: 1536 GHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA-HRA 1594
+ + ++ Q ++ + I Q + +LK+ W + + +R +LEEA + A
Sbjct: 4481 AKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLA 4540
Query: 1595 QQYYFDAAEAEAWMSEQELYM-MSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSK 1653
+++ + W+++ E + ++ + + + + +H++ V + E + +L K
Sbjct: 4541 MEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDK 4600
Query: 1654 TSRALVADSHPE-----SERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVD 1708
T L S + + QS+ +K+ ++ L E R D R R Q +
Sbjct: 4601 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKV---VQRLVERGRSLDDARKRAKQFHEAWS 4657
Query: 1709 DLEQWIAEREVVAGSH-ELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELIN 1767
L +W+ E E S E+ D + + + +EF + G DT N L
Sbjct: 4658 KLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLG-AKHSVYDTTNRTGRSL-- 4714
Query: 1768 SGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKK 1827
+ ++A+ L++ ++L + DT I S E +A G+ D +
Sbjct: 4715 ---KEKTSLADDNLKLDDMLSELRDKWDT---ICGKSVERQNKLEEALLFSGQFTDALQA 4768
Query: 1828 LPEELGR-------------DQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAY 1874
L + L R D + V L H F+ ++ + V+ L+ A L
Sbjct: 4769 LIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG- 4827
Query: 1875 AGDKADDIQKRENEVLEAWKSLLDACESRRVRL-VDTGDKFRFFSMVRDLMLWMEDVIRQ 1933
+ D + ++ + E+ W+++ S++ RL F S+V L+ W+ + +
Sbjct: 4828 SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQT 4887
Query: 1934 IEAQ-EKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKL 1992
+ P D ++ L++ H+ +++ + +G ++LA H S +
Sbjct: 4888 LRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHW 4947
Query: 1993 LQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAE---AWLLGQEPYLSSRE---IG 2046
+ + R E + W + + RL + + E AWL E L+ ++ I
Sbjct: 4948 ITIIRARFEEVLAWAKQHQ-QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 5006
Query: 2047 QSVDEVEKLIKRHEAF 2062
Q ++EV+ LI H+ F
Sbjct: 5007 QEIEEVKALIAEHQTF 5022
Score = 209 bits (533), Expect = 2e-53
Identities = 320/1645 (19%), Positives = 687/1645 (41%), Gaps = 105/1645 (6%)
Query: 387 KLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSE-NQRLV 445
K +S ++ WE L R L E + +A++F WL+ +RLV
Sbjct: 3416 KQLSLLDSRWEALLNKAETRNRQL-------EGISVVAQQFHETLEPLNEWLTTIEKRLV 3468
Query: 446 SQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDN 505
+ + G +E +H+A+E DI + + + V++ + L+ + + K + K +
Sbjct: 3469 NCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLD 3528
Query: 506 VIRLWEY-LLELLRARRQRLEMNLGLQKIF-QEMLYIMDWMDEM--KVLVLS-QDYGKHL 560
++W + E +R + L+ L KIF ++ + +M+W++E+ K+ LS QDY
Sbjct: 3529 FSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE- 3587
Query: 561 LGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCY 620
G+ + +++ DI ++ + V + + G + +I+D++ ++ Y
Sbjct: 3588 -GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTG---DEVLIIQDKLEAIKARY 3643
Query: 621 QELCQLAAERRARLEESRRLWKFFWEMAEEE-GWIREKE-KILSSDDYGKDLTSVMRLLS 678
+++ +L+ + LE++ +L + EE W+ + E ++LS + +
Sbjct: 3644 KDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQM 3703
Query: 679 KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 738
+ + + E + + ++ + + + E+++ + L + +K
Sbjct: 3704 RPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKV 3763
Query: 739 RLEEASLL--HQFQADADDIDAWMLDI-LKIVSSSDVGHDEYSTQSLVKKHKDVAEEIAN 795
+A++L QF AD +W+ + K++S D+ ++ T + ++ K EI
Sbjct: 3764 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3823
Query: 796 YRPTLDTL----HEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLAL 851
++ +D L H+ +A +E +S ++ +L + + Y + ++ R L+ +L
Sbjct: 3824 HKDIIDDLVKSGHKIMTACSEEEKQS--MKKKLDKVLKNYDTICQINSERYLQLERAQSL 3881
Query: 852 YKMFSEA-DACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNNQASRVAVVN 909
F E + W+ E + ++ + P + E L Q L + + +N
Sbjct: 3882 VNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMN 3941
Query: 910 QIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALS-IQNYHLECNETK 968
+ QL+ I+ + +T +SQ +E V ++ AL A+S +H + ++
Sbjct: 3942 KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 4001
Query: 969 SWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL-----E 1023
+ + + + ++ + + + D+ ++ L++ E++
Sbjct: 4002 ESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGG 4061
Query: 1024 SEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQ 1082
++ A+A+ +L ++ +WE + T ++ REA L + +L ++F D + TQ
Sbjct: 4062 TDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQ 4121
Query: 1083 TAIASEDMPNTLTEAEKLLTQ-HENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1141
I + P K + E I+ EID +E+ + ++G + + ++
Sbjct: 4122 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4181
Query: 1142 QRLQALDTGWNELHKMWENRQNLLSQS-HAYQQFLRDTKQAEAFLNNQEYVLAH-TEMPT 1199
+ + L++ W+ L+K W++R + L ++ A Q+ + +++ LA + + T
Sbjct: 4182 KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT 4241
Query: 1200 TLEGAEAAIKKQEDFMT---TMDANEEKINAVVETGRRLV---SDGNINSDRIQEKV--- 1250
LE + I++ + F + E++N E + V SD + D + E
Sbjct: 4242 DLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIW 4301
Query: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWI--NEKMLTAQDMSYDEARN 1308
DS+++R + L+ L +F EL W+ E +L+ Q + +
Sbjct: 4302 DSLEERIINRQHKLEGALLA------LGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKA 4355
Query: 1309 LHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAV-VKEKLTGLHKMWE-VLE 1366
+ + KH ++ +++ ++ + K G LI EA ++ KL L++ W+ VLE
Sbjct: 4356 IEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLE 4415
Query: 1367 STTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLE 1426
T Q K Q +A+ F DL +WL E + + K L + K+Q +
Sbjct: 4416 KTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLA---SKPLGGLPETAKEQLNVH 4472
Query: 1427 NQMEVRKKEIEE-----LQSQAQALSQEGKSTD-EVDSKRLTVQTKFMELLEPLNERKHN 1480
++ + EE +Q Q L++ KS + +D ++ K+ + LNERK
Sbjct: 4473 MEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTK 4532
Query: 1481 LLASKEI-HQFNRDVEDEILWVGE-RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQ 1538
L + + +F+ ++D I W+ + L ++ L TV I +++ E+ H+
Sbjct: 4533 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4592
Query: 1539 PRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAH-RAQQY 1597
+I ++ + ++ S I+ L ++ W +++ +R R L++A RA+Q+
Sbjct: 4593 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4652
Query: 1598 YFDAAEAEAWMSEQELYMMSE-EKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSR 1656
+ ++ W+ E E + SE E A D + L +H+ ++++ ++T R
Sbjct: 4653 HEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGR 4712
Query: 1657 ALVADSHPESERISMRQSKVDKLYAGLKD-------LAEERRGKLDERHRLF--QLNREV 1707
+L E ++ K+D + + L+D + ER+ KL+E LF Q +
Sbjct: 4713 SL-----KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEA-LLFSGQFTDAL 4766
Query: 1708 DDLEQWIAERE-VVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELI 1766
L W+ E +A + D + V L + + F ++ G V + A ELI
Sbjct: 4767 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALKRSARELI 4825
Query: 1767 NSGHSDAATIAEWKDGLNEAWADLLEL-IDTRTQILAA---SYELHKFYHDAKEIFGRIQ 1822
D++ + L+ W + L I +T++ AA + E H H E +
Sbjct: 4826 EGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAE 4885
Query: 1823 DK---HKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKA 1879
H LP+ D++ + TL H F ++ ++ + + A D
Sbjct: 4886 QTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSI 4941
Query: 1880 DDIQKRENEVLEAWKSLLDACESRRVRLVDT----GDKFRFFSMVRDLMLWMEDVIRQIE 1935
I+ + ++ +L + + RL K + + W E + +
Sbjct: 4942 TTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKD 5001
Query: 1936 AQEKPRDVSSVELLMNNHQGIKAEI 1960
+ P+++ V+ L+ HQ E+
Sbjct: 5002 KEVIPQEIEEVKALIAEHQTFMEEM 5026
Score = 162 bits (409), Expect = 5e-39
Identities = 251/1319 (19%), Positives = 543/1319 (41%), Gaps = 103/1319 (7%)
Query: 305 EKYESLASDLLEWIEQT---IIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGN 361
++++ A L WI +T ++ L + + Q Q+Q T + K
Sbjct: 3774 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR------HKDI 3827
Query: 362 LEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLE 421
++ L+ + M A +++ + KL + K ++ + + ER L L E+ +
Sbjct: 3828 IDDLVKSGHKIMTACSEEEKQSMKKKL-DKVLKNYDTICQINSERYLQL-------ERAQ 3879
Query: 422 QLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAAT-----KKHEAIETDIAAYEE 476
L +F WL+E Q ++SQ PA+E T ++H + IA ++
Sbjct: 3880 SLVNQFWETYEELWPWLTETQSIISQ----LPAPALEYETLRQQQEEHRQLRELIAEHKP 3935
Query: 477 RVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQE 536
+ + +L + + I + L+ + E ++ R L+ + F +
Sbjct: 3936 HIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 3995
Query: 537 ML-YIMDWMDEM-KVLVLSQDYGKHLLGVEDLLQKHTLVEADIG-----IQAERVRGVNA 589
+ I++ ++ + + L + +++ + ++ V D+ + + RG
Sbjct: 3996 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4055
Query: 590 SAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFW---- 645
A+ TD K + ++D++ M F ++ + L ER A+L + L + FW
Sbjct: 4056 IARSGGTD----KDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHM 4111
Query: 646 ----EMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEG 701
+ + + +IR+ E D G D + V + +E+ G + I G
Sbjct: 4112 SLIVTIKDTQDFIRDLE------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLG 4165
Query: 702 EDMIAEEHFGSEKI-RERIIYIREQWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAW 759
++IA + I ++ I + W +L + R +LEEA Q+Q + W
Sbjct: 4166 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4225
Query: 760 MLDIL--KIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAES 817
+ DI K+ S S +G D + + +++ K E + ++ L+ QA L ++ E
Sbjct: 4226 V-DIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4284
Query: 818 PD---VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEA-DACELWIDEKEQWLN 873
D V+ L ++ + + E R+ L+ L F A D W+ E L+
Sbjct: 4285 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS 4344
Query: 874 NMQI----PEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE-KEIKA 928
+ P+ +E +E+ +H L+ ++ S V VN+ L+ S E ++
Sbjct: 4345 EQKPVGGDPKAIE-IELAKHHV--LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4401
Query: 929 QQDKLNTRWSQFRELVDRKKDALLSAL-SIQNYHLECNETKSWIREKTKVIESTQDLGND 987
+ + LN RW E +++K L AL + +H E + + W+ + + + +++ LG
Sbjct: 4402 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-- 4459
Query: 988 LAGVMALQRKLTGMERDL-VAIEAK---LSDLQKEAEKLESEHPDQAQAILSR-LAEISD 1042
G+ ++ + ++ A EAK L ++ +++ + P A+ + + + + +
Sbjct: 4460 --GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE 4517
Query: 1043 VWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKL- 1100
WE ++T L R+ L EA L +F L DF +WL++ + + P+ + +
Sbjct: 4518 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ 4577
Query: 1101 LTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNEL-HKMWE 1159
+ +H+ NE++++ E ++ G + + ++ L ++ + W ++ ++ E
Sbjct: 4578 IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4637
Query: 1160 NRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVL-AHTEMPTTLEGAEAAIKKQEDFMTTM 1218
++L +QF + +L E L + E+ + + + + ++F ++
Sbjct: 4638 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4697
Query: 1219 DANEEKINAVVETGRRL-----VSDGNINSD----RIQEKVDSIDDRHRKNRETASELLM 1269
A + TGR L ++D N+ D +++K D+I + + + E L+
Sbjct: 4698 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4757
Query: 1270 RLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEW 1329
D + L D L+ E L + + + + H+AF EL
Sbjct: 4758 FSGQFTDALQALIDW----LYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSS 4813
Query: 1330 LDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA-NKAELFTQS 1388
+ +++ +LI + + VK ++ L WE + + + +K RL A +AE F
Sbjct: 4814 VQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSV 4873
Query: 1389 CADLDKWLHGLESQIQSDDY-GKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALS 1447
L +WL E ++ D ++ L+ + + ++E ++ E+ + + +
Sbjct: 4874 VHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4933
Query: 1448 Q--EGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEIL-WVGER 1504
S + ++ +F E+L + + L ++ +++ + +L W+
Sbjct: 4934 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 4993
Query: 1505 MPLATSTDHG---HNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSA 1560
T D ++ V+ LI ++QT +E+ QP +D + + + D SSL +
Sbjct: 4994 ETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQS 5052
Score = 149 bits (375), Expect = 4e-35
Identities = 333/1806 (18%), Positives = 719/1806 (39%), Gaps = 200/1806 (11%)
Query: 277 FSKMKALAVEGKRIGKVLDNAIETEKMI-----EKYESLASDLLEWIEQTIIILNNRKFA 331
FSK K + E + L A++T ++ +K + LE +T+ N F+
Sbjct: 1500 FSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS 1559
Query: 332 NSLVGVQQQLQAFNTYRTV--------EKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMP 383
SL +QLQ T V E+ ++ EK L T +Q+ +M
Sbjct: 1560 ESL----KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI 1615
Query: 384 REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR 443
+G + L+K + ++E EL Q+ ++ A+ E +L EN
Sbjct: 1616 GDGTV---------ELKKYQSKQE-----EL--QKDMQGSAQALAEVVKNTENFLKENGE 1659
Query: 444 LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 503
+SQ++ + A K E + ++ + VV A + E E +K++ K
Sbjct: 1660 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESK 1719
Query: 504 DNVIRLWEYLLELLR-------ARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 556
+ L ++L + + +Q +E N G + + DE+ +L D
Sbjct: 1720 TKIENLLDWLSNVDKDSERAGTKHKQVIEQN-GTHFQEGDGKSAIGEEDEVNGNLLETDV 1778
Query: 557 -GKHLLGVEDLLQKHTLVEAD---IGIQAERVRGVNASAQ-KFATDGEGYKPCDPQVIRD 611
G+ E+L Q++ V+A I Q + V SAQ G+ P + + ++
Sbjct: 1779 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1838
Query: 612 RVAHMEFCYQELCQLAAERRARLEES--RRLWKFFWEMAEEEGWIREKEKILSSDDYG-K 668
+ ++ Y E +E++ +L S L KF + E E W+++ E+ L + + G
Sbjct: 1839 NMKELKVHY-ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1897
Query: 669 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK-------------I 715
D+ +M L + ++F +++ G G ++ S++ +
Sbjct: 1898 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 1957
Query: 716 RERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADAD-----DIDAWMLDILKIVSSS 770
+ ++ + +++ +L + L++ +Q DA + A K + S
Sbjct: 1958 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SE 2016
Query: 771 DVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAE----SPDVRGRLSG 826
+ D + Q +++ K + +I++ + ++ L + A L D++ L
Sbjct: 2017 PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDD 2076
Query: 827 IEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNM--------QIP 878
I RY+++++ R + LQ TL + S D +DE W+ N+ Q+P
Sbjct: 2077 IVGRYEDLSKSVNERNEKLQITLT--RSLSVQDG----LDEMLDWMGNVESSLKEQGQVP 2130
Query: 879 EKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWS 938
L+ I + LE ++ + S + +N+ ++ M + PS + Q K+ +
Sbjct: 2131 LNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPS--TASSLQAKMKDLSA 2188
Query: 939 QFRELVDRKKDALLS----ALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMAL 994
+F E + K+ L ++ + + ++++ KT+ + G D+ +
Sbjct: 2189 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2248
Query: 995 QRKLTGMERDLVAIEAKLSDLQKEAEKLESEH-PDQAQAILSRLAEISDVWEEMKTTLK- 1052
++ T + + + L L +++ S P +L + +S ++EM+ T+K
Sbjct: 2249 MQESTS---EFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2305
Query: 1053 NREASLGEASKLQQFLRDLDDFQSWLSRT-------QTAIASEDMPNTLTEAEKLLTQHE 1105
+EA +L F + +SW+ T Q + +ED+ +L + +KL +
Sbjct: 2306 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWS 2365
Query: 1106 NIKNEIDNYEEDYQKMRDMG----EMVTQGQTDAQYMFLRQRLQALDTG---WNELHKMW 1158
EI QK+ + G +++ T A+ + + A+ G + W
Sbjct: 2366 LKTPEI-------QKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2418
Query: 1159 EN------RQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVL-------------------- 1192
N ++++ SH Y+ K A LN + L
Sbjct: 2419 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT 2478
Query: 1193 ----AHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDG--NINSDRI 1246
T PT E + +++ + F + N K+ + + L+ + + R
Sbjct: 2479 ATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW 2538
Query: 1247 QEKVDSIDDRHRKNRETASELLMRLKD-NRDLQKFLQDCQELSLWINEKMLTAQ---DMS 1302
++ + ID + ++ + + +L++ + +L +F +L W+ EK L +S
Sbjct: 2539 KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLS 2598
Query: 1303 YDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLIS---EKPETEAVVKEKLTGLH 1359
D L+++ + Q + E A+ K +++ G ++S E P +VKE+L +
Sbjct: 2599 ID-PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2657
Query: 1360 KMWEVLESTTQTKAQRLFDA-NKAELFTQSCADLDKWLHGLESQIQSD-DYGKDLTSVNI 1417
+ W+ L + + A K+ + L L L++++ S ++N
Sbjct: 2658 QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ 2717
Query: 1418 LLKKQQMLENQMEVRKKEIEELQSQAQ---ALSQEGKSTDEVDSKRLTVQTKFMELLEPL 1474
L+ Q ++ +++ KK+I+ Q+ + AL +E E+ + + F ++ +
Sbjct: 2718 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKA 2777
Query: 1475 -NERKHNLLASKEIHQFNRDVEDEILWVG-ERMPLATSTDHGHNLQTVQLLIKKNQTLQK 1532
N +H A HQF + D W+ ++ S L ++ LIK ++ K
Sbjct: 2778 ENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2837
Query: 1533 EIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA- 1591
+ + +N++ + A++ +L +K W ++ ++R +L+E+
Sbjct: 2838 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 2897
Query: 1592 HRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQL 1651
+A +Y W+ + + + + D + + K + L++ ++ + V L
Sbjct: 2898 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELL 2957
Query: 1652 SKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREV--DD 1709
+ T+ +L++ + E ++ + + + + ++ L+ + F+ +EV +
Sbjct: 2958 NNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 3017
Query: 1710 LEQWIAEREVVAGSHELG-QDY--EHVTMLQERFREFARDTGNIGQERVDTVNHLADELI 1766
Q +E + LG Q Y +++TMLQ + + + +VD LA +L+
Sbjct: 3018 KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSL-----QALKHQVDLAKRLAQDLV 3072
Query: 1767 -----NSGHSD----AATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEI 1817
+ G SD TIA+ L++ + ++T+ Q + F + +E+
Sbjct: 3073 VEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQ------GIGHFQNTIREM 3126
Query: 1818 FGRIQDKHKKLPE--ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYA 1875
F + + +L +GRD T++ + F ++AL + + A
Sbjct: 3127 FSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA--T 3184
Query: 1876 GDKADDIQ--KRENEVL-EAWKSLLDACESRRVRLVDTGDKF-RFFSMVRDLMLWMEDVI 1931
+ + D+ KR+ E L + LLD ++R ++ T + F+S +++ + ++
Sbjct: 3185 EETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE 3244
Query: 1932 RQIEAQ 1937
E+Q
Sbjct: 3245 EHEESQ 3250
Score = 137 bits (345), Expect = 1e-31
Identities = 280/1593 (17%), Positives = 637/1593 (39%), Gaps = 158/1593 (9%)
Query: 158 QIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNAL------ 211
Q+ I ++ + + + + AL C K G V + N+ D ++ ++
Sbjct: 3531 QVWYIEIQEKSHSRSELLQQAL---CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3587
Query: 212 -IHKHRPDLIDFDK---LKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSII 267
+ K + +L + L+K N L N L +Q G L+ + +
Sbjct: 3588 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEA--------- 3638
Query: 268 TYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNN 327
+ Y +K+ + K L+ A++ + + S +L W+++ + L +
Sbjct: 3639 --IKARYKDITKLST------DVAKTLEQALQ---LARRLHSTHEELCTWLDKVEVELLS 3687
Query: 328 RKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKV-YMPREG 386
+ ++ ++ QA + ++K K N + LL ++ A + V + REG
Sbjct: 3688 --YETQVLKGEEASQAQMRPKELKKEAK-----NNKALLDSLNEVSSALLELVPWRAREG 3740
Query: 387 --KLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR- 443
K++++ N+ + + ++ + ++R ++ FD+ A +W++E ++
Sbjct: 3741 LEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ-------FDQAADAELSWITETEKK 3793
Query: 444 LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 503
L+S + + A + + +I +++ + +V ++ + K+ +K
Sbjct: 3794 LMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKK 3853
Query: 504 -DNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY-IMDWMDEMKVLVLSQDYGKHLL 561
D V++ ++ + ++ R +LE L F E + W+ E + ++ L
Sbjct: 3854 LDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSII--SQLPAPAL 3911
Query: 562 GVEDLLQK---HTLVEADIGIQAERVRGVNASAQKFA--TDGEGYKPCDPQVIRDRVAHM 616
E L Q+ H + I + +N + + + GEG+ I+++
Sbjct: 3912 EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS------IQEKYVAA 3965
Query: 617 EFCYQELCQLAAERRARLEESRRLWKFFWEMAEE--EGWIREKEKILSSDDYGKDLTSVM 674
+ Y ++ + +R L+E+ F + ++ E R E++ ++ +
Sbjct: 3966 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 4025
Query: 675 RLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIA-----EEHFGSEKIRERIIYIREQWANL 729
+S+++ +M +E + GE+MIA ++ ++ +++++ + W N+
Sbjct: 4026 EQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI 4085
Query: 730 EQLSAIRK-KRLEEASLLHQFQADADDIDAWMLDILKIVSS-SDVGHDEYSTQSLVKKHK 787
L R+ K L+ L +F D + + D + D G D + + +
Sbjct: 4086 HTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4145
Query: 788 DVAEEIANYRPTLDTLHEQASALPQEHAE--SPDVRGRLSGIEERYKEVAELTRLRKQAL 845
+ EEI + LD + S L E P V+ + + + + + + R L
Sbjct: 4146 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4205
Query: 846 QDTLALYKMFSEA-DACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASR 904
++ + + + A W+D L +M DLE ++ + E L+ Q
Sbjct: 4206 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT--DLETVKQQIEELK-----QFKS 4258
Query: 905 VAVVNQIARQ-LMHSGHPSEKEIKAQQDK---------LNTRWSQFRELVDRKKDALLSA 954
A QI + L H K++ + DK L W E + ++ L A
Sbjct: 4259 EAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4318
Query: 955 L-SIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLS 1013
L ++ + +E +W+ ++ + +G D + K ++ D++A ++ +
Sbjct: 4319 LLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVE 4378
Query: 1014 DLQKEAEKL-ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASL-GEASKLQQFLRDL 1071
+ K L ES ++A + ++L ++ W+ + + R+ L G + + F ++
Sbjct: 4379 AVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEI 4438
Query: 1072 DDFQSWLSRTQT-AIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV-- 1128
+D Q WL+ T+ +AS+ + A++ L H + + EE Y+ + G+ +
Sbjct: 4439 EDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLA 4498
Query: 1129 -----TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSH-AYQQFLRDTKQAE 1182
+ D L+++ ++++T NE E NL + H + Q F+ QAE
Sbjct: 4499 RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4558
Query: 1183 AFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRL-VSDGNI 1241
LN + L+ I + + F ++++ E+I + +TG L
Sbjct: 4559 QTLN------VASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQ 4612
Query: 1242 NSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK-FLQDCQELSLWI--NEKMLTA 1298
+ I+ + S+ R K + E L D R K F + +L W+ +EK L +
Sbjct: 4613 DVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDS 4672
Query: 1299 QDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVK--EKLT 1356
+ ++ + ++ +H+ F L + D + G L + + +K + L+
Sbjct: 4673 ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLS 4732
Query: 1357 GLHKMWEVLESTTQTKAQRLFDANK-AELFTQSCADLDKWLHGLESQIQSDD--YGKDLT 1413
L W+ + + + +L +A + FT + L WL+ +E Q+ D +G D+
Sbjct: 4733 ELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DID 4791
Query: 1414 SVNILLKKQQMLENQMEVRKKEIEELQSQAQAL---SQEGKSTDEVDSKRLTVQTKFMEL 1470
V L+ + + ++ R ++ L+ A+ L S++ S +V + L+ + + +
Sbjct: 4792 LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCA 4851
Query: 1471 LEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHG---HNLQTVQLLIKKN 1527
L ++++ A ++ +F+ V + W+ E T HG + ++ LI ++
Sbjct: 4852 LS-ISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQ--TLRFHGVLPDDEDALRTLIDQH 4908
Query: 1528 QTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRR 1587
+ K+++ + ++ ++ S I+ + ++ + ++ ++ +R
Sbjct: 4909 KEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQR 4968
Query: 1588 LEEAHRAQQYYFDAAEAE-AWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAE 1646
L A + EA AW+ E + ++K +++ Q +E+
Sbjct: 4969 LASALAGLIAKQELLEALLAWLQWAETTLTDKDK--------------EVIPQEIEEV-- 5012
Query: 1647 TVHQLSKTSRALVADSHPESERISMRQSKVDKL 1679
+AL+A+ E ++ +Q VDK+
Sbjct: 5013 ---------KALIAEHQTFMEEMTRKQPDVDKV 5036
Score = 130 bits (326), Expect = 2e-29
Identities = 345/1826 (18%), Positives = 720/1826 (39%), Gaps = 221/1826 (12%)
Query: 359 KGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQE 418
K EVLL S + A N K + DI +E L K+ +ER L+ L R
Sbjct: 2050 KKTAEVLLDARGSLLPAKNDIQ------KTLDDIVGRYEDLSKSVNERNEKLQITLTRSL 2103
Query: 419 KLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERV 478
++ D M + + L Q + A++ K+ +E DIA + +
Sbjct: 2104 SVQ------DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSI 2157
Query: 479 QAV------------VAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEM 526
A+ + A L+A+ +K ++AR + L + + ++E+
Sbjct: 2158 NAMNEKVKKFMETTDPSTASSLQAK----MKDLSARFSEASHKHKETLAKMEELKTKVEL 2213
Query: 527 NLGLQKIFQEMLYIMDWMDEMKVLVLSQDY--GKHLLGVEDLLQKHTLVEADIGIQAERV 584
L + Q L E K L++ GK + + +Q+ T ++ + +
Sbjct: 2214 FENLSEKLQTFL-------ETKTQALTEVDVPGKDVTELSQYMQEST---SEFLEHKKHL 2263
Query: 585 RGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFF 644
+++ ++ ++ G P D ++ ++ ++ ++E+ E++ + + F
Sbjct: 2264 EVLHSLLKEISSHG---LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2320
Query: 645 WEMAEE-EGWIREKEKIL-------SSDDYGKDLTSVMRLLSKHRAFEDEMS--GRSG-- 692
+ + + WI+E K + ++D GK L +L K E+ SG
Sbjct: 2321 QVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGIS 2380
Query: 693 --HFEQAIKEGEDMIAEEHFGSEKIRER--IIYIREQWAN----------------LEQL 732
+ A+ IA G + E WAN E L
Sbjct: 2381 LCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDL 2440
Query: 733 SAIRKKRLEEA----SLLHQFQADADDIDAWMLDILKIVSS---SDVGHDEYSTQSLVKK 785
+ K ++ E S L + Q ++ + W+ + K + + D + ++ V++
Sbjct: 2441 GLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQ 2500
Query: 786 HKDVAEEIANYRPTLDTLHEQASALPQEHAESPDV---RGRLSGIEERYKEVAELTRLRK 842
+K E+ + L ++ + L +E+ ++P+ + L+ I+ +++E+ +LT R+
Sbjct: 2501 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2560
Query: 843 QALQDTLALYKMFSEADA-CELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEM-NN 900
Q L+++ F +A + W+ EKE ++ L L S++P M N
Sbjct: 2561 QKLEESSNNLTQFQTVEAQLKQWLVEKELMVS------VLGPL--------SIDPNMLNT 2606
Query: 901 QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFREL----------VDRKKDA 950
Q +V QI Q + P +++ A + +R + L V +K D+
Sbjct: 2607 QRQQV----QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2662
Query: 951 LLSALS-----IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDL 1005
L LS I ++ + +S +R + + DL N L+ +A+ M + L
Sbjct: 2663 LTGQLSDRCDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVSTHPDAMNQQL 2719
Query: 1006 VAIEAKLSDLQKEAEKLESEHP-----------DQAQAILSR-----LAEISDVWEEMKT 1049
+ ++Q+E ++++ + +A LSR L DV ++ +
Sbjct: 2720 ETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2779
Query: 1050 TLKNREASLGEASKLQQFLRDLDDFQSWL-SRTQTAIASEDMPNTLTEAEKLLTQHENIK 1108
+++ +++ + + QQ RD FQ+WL ++ + S + L E L+ H++
Sbjct: 2780 HVQHLQSACASSHQFQQMSRD---FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2836
Query: 1109 NEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQS 1168
+ Y+K GE + ++ L+ +L + T W+ +K + R+N L +S
Sbjct: 2837 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES 2896
Query: 1169 HAYQQFLRDTKQAEAF-------LNNQEYVLAHTEMPTTLEGAEA--AIKKQEDFMTTMD 1219
++ L+ +Q E NN E E+ L+ AE +I K + MD
Sbjct: 2897 --LEKALKYKEQVETLWPWIDKCQNNLE------EIKFCLDPAEGENSIAKLKSLQKEMD 2948
Query: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQ-------EKVDSIDDRHRKNRETASELLMRLK 1272
+ + + T L+S I+ + + +KVD + ++ + + + K
Sbjct: 2949 QHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3008
Query: 1273 DNRDLQKFLQ---DCQELSLWINEKM----LTAQDMSYDEARNLHSKWLKHQAFMAELAS 1325
+ +++ K + C + L I++ + + + ++ + + + LKHQ +A+ +
Sbjct: 3009 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3068
Query: 1326 NKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL--FDANKAE 1383
++ + +G + + ET + ++ + L + + S +TK Q + F E
Sbjct: 3069 QDLVVEASDSKGTSDVLLQVET---IAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIRE 3125
Query: 1384 LFTQSCADLDKWLHGLES-QIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ 1442
+F+Q A+ D L + ++ K ++ LKK + L + K + +
Sbjct: 3126 MFSQ-FAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM--- 3181
Query: 1443 AQALSQEGKSTDEVDSKR--LTVQTKFMELLEPLNERKHNLLAS-KEIHQFNRDVED-EI 1498
L+ E S D V KR + + +LL+ R+ + + K + +F +++ I
Sbjct: 3182 ---LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI 3238
Query: 1499 LWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQK-EIQGHQPRIDDIFERSQNIVTDSS- 1556
L + G +T+ + + QK EI+ Q + D+ Q ++ ++
Sbjct: 3239 LLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK 3298
Query: 1557 SLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEA-EAWMSEQELYM 1615
S S + + L D+ W L ++ +R +L+EA + DA E+ +WM + E +
Sbjct: 3299 STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV 3358
Query: 1616 MSEEKAKDEQSAV-SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHP-ESERISMRQ 1673
+++ E V + +++ ++L++ ++D TV + + + + P + +I +
Sbjct: 3359 ANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQL 3418
Query: 1674 SKVDKLYAGLKDLAEERRGKLDERHRLF-QLNREVDDLEQWIAEREV-VAGSHELGQDYE 1731
S +D + L + AE R +L+ + Q + ++ L +W+ E + +G
Sbjct: 3419 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3478
Query: 1732 HVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLL 1791
+ + + D N + V+ + S D + D + ++
Sbjct: 3479 KLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3538
Query: 1792 ELIDTRTQIL-AASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHT--- 1847
E +R+++L A F D E+ + + H KL + +D +T E L + +
Sbjct: 3539 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYST-EGLWKQQSELR 3597
Query: 1848 TFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRL 1907
+ DI V Q + L GD+ IQ + + +K + L
Sbjct: 3598 VLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3657
Query: 1908 VDTGD-KFRFFSMVRDLMLWMEDVIRQIEAQE----KPRDVSSVEL----LMNNHQGIKA 1958
R S +L W++ V ++ + E K + S ++ L + KA
Sbjct: 3658 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3717
Query: 1959 EIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMI-DKWEDRWEWL-RLI 2016
+D+ N E+ +LL + + E EK++ +R ++ D + E + I
Sbjct: 3718 LLDSLN-------EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3770
Query: 2017 LEVHQFSRDASVAEAWLLGQEPYLSS 2042
L QF + A +W+ E L S
Sbjct: 3771 LRSQQFDQAADAELSWITETEKKLMS 3796
Score = 104 bits (260), Expect = 9e-22
Identities = 330/1756 (18%), Positives = 665/1756 (37%), Gaps = 240/1756 (13%)
Query: 627 AAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTS-VMRLLSKHRAFED 685
AAE +L E++ + EEE I +K I + K S V A ED
Sbjct: 1212 AAEALVKLYETK--------LCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALED 1263
Query: 686 EMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASL 745
E+ ++ K ++ + + EK + + E+W N+ R + LE
Sbjct: 1264 ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLV----ERWQNVHVQIDNRLRDLEGIGK 1319
Query: 746 LHQFQADA-DDIDAWMLDI----LKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTL 800
++ D +D W+ + KI + +TQ + + K + EI + +
Sbjct: 1320 SLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ--LNQQKMLVSEIEMKQSKM 1377
Query: 801 DTLHEQAS-----------------ALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQ 843
D + A A+ +SP R R+ + + R R
Sbjct: 1378 DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYT 1437
Query: 844 ALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE--------VIQHRFESLE 895
AL + Y F+ L +EK + EK ++L+ ++ ++ +
Sbjct: 1438 ALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGK 1497
Query: 896 PEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKL-NTRWSQFRELVDRKKDALLSA 954
P + Q ++ QL + + + DK+ + ++ + V +++
Sbjct: 1498 PPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL 1557
Query: 955 LSIQNYHLECNETKSWIREKTKVI-ESTQDLGNDLAGVMALQRKLTGMERDLVAIE---- 1009
S L+ ++T ++ + K++ E Q+ L G+ L LT E L+ +
Sbjct: 1558 FSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDL---LTQTENRLIGHQEAFM 1614
Query: 1010 -----AKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEAS-- 1062
+L Q + E+L+ + AQA+ + + +E L + +L E
Sbjct: 1615 IGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLN 1674
Query: 1063 ----KLQQFLRDLDDFQSWLSRTQTAIASEDMPNT--LTEAEKLLTQHENIKNEIDNYEE 1116
K +Q + + L + T E+ + + E+ T+ EN+ + + N ++
Sbjct: 1675 EAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDK 1734
Query: 1117 DYQKMRDMG-EMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFL 1175
D ++ +++ Q T Q + + D L + + Q +Q + QQ+
Sbjct: 1735 DSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQ 1794
Query: 1176 RDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRL 1235
+ Q E ++ + V+ T+ A+ ++KQ +++ EEK
Sbjct: 1795 KVKAQHEKIISQHQAVIIATQ------SAQVLLEKQGQYLSP----EEK----------- 1833
Query: 1236 VSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDN--RDLQKFLQDCQELSLWI-- 1291
+++Q+ + + H + SE M+L + +L+KF D E W+
Sbjct: 1834 --------EKLQKNMKELKV-HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQ 1884
Query: 1292 NEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE-------- 1343
+E+ L + D+ L +K + ++F ++ S+K L I G +++
Sbjct: 1885 SEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRD 1944
Query: 1344 --KPETEAV---VKEKLTGLHKMWEVLESTTQTKAQRLFD-ANKAELFTQSCADLDKWLH 1397
K +T A V+ KL + L S L D +K + + + L L
Sbjct: 1945 GGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQ 2004
Query: 1398 GLE---SQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKST- 1453
E S+ S+ D ++ L++ + L+ Q+ ++ +E+L+ A+ L S
Sbjct: 2005 ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLL 2064
Query: 1454 ---DEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEIL-WVGE-RMPLA 1508
+++ + ++ +L + +NER L + +D DE+L W+G L
Sbjct: 2065 PAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 2124
Query: 1509 TSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLA 1568
N +Q +I KN L+++I G Q I+ + E+ + + + +A +++ ++
Sbjct: 2125 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 2184
Query: 1569 DLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSE----EKAKDE 1624
DL + + ++ ++EE + + + +E E + ++E K E
Sbjct: 2185 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 2244
Query: 1625 QSAVSMLKKHQILEQAVEDYAETVHQLSK--TSRALVADSHPESERISMRQSKVDKLYAG 1682
S + LE + + E +H L K +S L +D + + + + K +
Sbjct: 2245 LSQYMQESTSEFLEH--KKHLEVLHSLLKEISSHGLPSD----KALVLEKTNNLSKKFKE 2298
Query: 1683 LKDLAEERRGKLDE-RHRLFQLNREVDDLEQWIAER-------EVVAGSHELGQDYEHVT 1734
++D +E++ + + +L V L+ WI E + G+ +LG+ E
Sbjct: 2299 MEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTK 2358
Query: 1735 MLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDG---LN-EAWADL 1790
LQE++ + + + N LI++ + A IA K G LN E A
Sbjct: 2359 KLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGAVLNGEGTATN 2413
Query: 1791 LELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVET-------LQ 1843
E + + ++ H +++ ++DK +L +L + Q E LQ
Sbjct: 2414 TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQ 2473
Query: 1844 RMHTTFEH--------DIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLE---- 1891
+M+ T D +A+ TQV Q + A L+ +K +++ + E+LE
Sbjct: 2474 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNV--NKVQELKDKLTELLEENPD 2531
Query: 1892 -----AWKSLLDACES-----------RRVRLVDTGDKFRFFSMVR-DLMLWM-EDVIRQ 1933
WK +L +S R+ +L ++ + F V L W+ E +
Sbjct: 2532 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2591
Query: 1934 IEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASE---EIKE 1990
D + + Q + E R + G+ +L+R +KE
Sbjct: 2592 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2651
Query: 1991 KLLQLTEKRKEMIDKWEDRWEWL-RLILEVHQFSR------------DASVAEAWLLGQE 2037
+L +T+K + + DR +W+ + I++ Q+ D ++ + +
Sbjct: 2652 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2711
Query: 2038 P------YLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLE----LLE 2086
P +++++ Q + + +K IK +A E +A E + E LE +
Sbjct: 2712 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2771
Query: 2087 VRRQQEEEERKRRPPSPEPSTKVSEEAESQQQW-DTSKGEQVSQNGLPAEQGSPRMAETV 2145
Q+ E + + S + + + Q W DT K EQ + + A+ +
Sbjct: 2772 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAK---------L 2822
Query: 2146 DTSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLN 2205
D E + K+ S + S KT ++ L +TQ + A ++ LN
Sbjct: 2823 DVLESL------IKDHKDFSKTLTAQSHMYEKTIAEGEN---LLLKTQGSEKAALQLQLN 2873
Query: 2206 R-KHEWEAHNKKASSR 2220
K W+ NK+ R
Sbjct: 2874 TIKTNWDTFNKQVKER 2889
Score = 98.6 bits (244), Expect = 6e-20
Identities = 318/1721 (18%), Positives = 645/1721 (37%), Gaps = 318/1721 (18%)
Query: 514 LELLRARRQRLEMNLGLQKIFQE---MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDLL 567
L+L++ R+ L+ +L Q + +E M ++ D W+DEM+V + ++G L VE L
Sbjct: 608 LKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHL 667
Query: 568 QKHTLV-----EADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQE 622
+ H V E + ++ ++ + +A T E ++ +E Y +
Sbjct: 668 ENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAE------------KLHRLESQYAK 715
Query: 623 LCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRA 682
L + + L+ L F E W+ EKE+ + D+ + T++ R H
Sbjct: 716 LLNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAE 772
Query: 683 FEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEE 742
E+ + + + + E ++ E H I ++ QW+ + QL ++ ++E
Sbjct: 773 LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKE 832
Query: 743 ASLLHQFQADADDIDAWMLDILKIVS---SSDVGHDEYSTQSLVKKHKDVAEEIANYRPT 799
+ +F DA + ++ ++ + S D + + LV++ + EE+ Y+ T
Sbjct: 833 NTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKST 892
Query: 800 LDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEAD 859
+ L +A + Q ++ R + T + +A+ D + + D
Sbjct: 893 IANLMGKAKTIIQ--------------LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDD 938
Query: 860 ACELWID-EKEQWL------NNMQIP-----------EKLEDLEVIQHRFESL------- 894
C L + + +W N +P E ++ I+ +++++
Sbjct: 939 ECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHES 998
Query: 895 EPEMNNQASRVAVVNQIARQLMHSGHPSEKEI--KAQQDKLNTRWSQFRE-LVDRKKDAL 951
M + S ++N+I R + S S K + Q L+ S+F + L D ++ +
Sbjct: 999 HINMKSVVSWHYLINEIDR-IRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQV 1057
Query: 952 LSALSIQNYHLECNETKSWIREKTKVIESTQD----LGNDLAGVMALQRKL--------- 998
S I E N K + +E K E + ++ V ++ +L
Sbjct: 1058 FSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIR 1117
Query: 999 ---TGMERD----LVAIEAKLSDLQKEAEKLESE---HPDQAQAILSRLAEISDV---WE 1045
T +ERD V + L+KE E+L+ + ++ + S+ A S V
Sbjct: 1118 QIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRS 1177
Query: 1046 EMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNT-LTEAEKLLTQH 1104
E+ L+N +S ++ L L TQ A A + T L E E ++
Sbjct: 1178 ELNVVLQNMNQVYSMSS---TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK 1234
Query: 1105 ENIKN----------EIDN-------YEEDYQKMRDMGEMV--TQGQTDAQYMFLRQRLQ 1145
NI+N E+D E++ QK + + + + T + D + + +++
Sbjct: 1235 NNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD 1294
Query: 1146 ALDTGWNELHKMWENRQNLLSQSHAYQQFLRDT--------------------------K 1179
L W +H +NR L ++ RDT K
Sbjct: 1295 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSK 1354
Query: 1180 QAEAFLNNQEYVLAHTEMPTT--------LEGAEAAIKKQE----DFMTTMDANEE---- 1223
LN Q+ +++ EM + E A +K E + +D+ ++
Sbjct: 1355 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVK 1414
Query: 1224 --------------------KINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRET 1263
+ A+V + + + R++E+ S+++ +++ E
Sbjct: 1415 RRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEK 1474
Query: 1264 ASEL-------LMRLKDNRDLQKFLQDCQELSL--------WINEKMLTAQ-------DM 1301
A EL LKD K Q++S ++E + T Q D
Sbjct: 1475 AKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDK 1534
Query: 1302 SYDEARNLHSKWLK--HQAFMAELASNKEWLDKIEKEGMQLISEK--PETEAVVKEKLTG 1357
DE RN K +K +++ + + + L + + G + EK E + KEKL G
Sbjct: 1535 MTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQG 1594
Query: 1358 LHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNI 1417
+ + TQT+ RL +A + +L K+ + ++Q D G +
Sbjct: 1595 ------ICDLLTQTE-NRLIGHQEAFMIGDGTVELKKY-QSKQEELQKDMQGSAQALAEV 1646
Query: 1418 LLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFME------LL 1471
+ + L K+ E+L + +AL ++ + ++ ++L ++ + + +
Sbjct: 1647 VKNTENFL-------KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1699
Query: 1472 EPLNERKHNLLASKEIHQFNRDVEDEILWVG--ERMPLATSTDHGHNLQTVQLLIKKNQT 1529
+ E + A K++ + +E+ + W+ ++ T H + +I++N T
Sbjct: 1700 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH-------KQVIEQNGT 1752
Query: 1530 LQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLE 1589
+E G + I + E + N++ ++ L Q + + +H ++
Sbjct: 1753 HFQEGDG-KSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQ-------KVKAQHEKII 1804
Query: 1590 EAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVH 1649
H+A A+ + +Q Y+ EEK K +++ + ++ E + H
Sbjct: 1805 SQHQA--VIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTH 1862
Query: 1650 QLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDD 1709
L + AD + + +++ L AG D+ + +L R+
Sbjct: 1863 SLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDI----------NGLMTKLKRQKSF 1912
Query: 1710 LEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSG 1769
E I+ + D ++T+ R E A+ +VDT
Sbjct: 1913 SEDVISHK----------GDLRYITISGNRVLEAAKSCSKRDGGKVDT------------ 1950
Query: 1770 HSDAATIAEWKDGLNEAWADLLELIDTRTQILAAS----YELHKFYHDAK-EIFGRIQ-- 1822
+AT E + L+ A D + ++ +L + + ++ Y DA + +Q
Sbjct: 1951 ---SATHREVQRKLDHA-TDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQAC 2006
Query: 1823 --DKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAG--DK 1878
K L E + D ++ + I + V +L++ A L A
Sbjct: 2007 EATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPA 2066
Query: 1879 ADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLML-WMEDVIRQIEAQ 1937
+DIQK ++++ ++ L + R +L T + D ML WM +V ++ Q
Sbjct: 2067 KNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ 2126
Query: 1938 EKP-------RDVSSVELLMNNH-QGIKAEIDARNDSFTTCIELG------------KSL 1977
+ +D+ S +++ G ++ I+A N+ +E K L
Sbjct: 2127 GQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2186
Query: 1978 LARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILE 2018
AR AS + KE L ++ E+ K ++ +E+ E L+ LE
Sbjct: 2187 SARFSEASHKHKETLAKM-EELKTKVELFENLSEKLQTFLE 2226
Score = 53.1 bits (126), Expect = 3e-06
Identities = 52/281 (18%), Positives = 116/281 (41%), Gaps = 28/281 (9%)
Query: 293 VLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAF-NTYRTVE 351
+LD + E++ K+ DLL W+++ + L+ ++ + L V+ L+ N +R +E
Sbjct: 622 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 678
Query: 352 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 411
+ ++ + + T K+ + + + + + ++ ER H
Sbjct: 679 EFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRAT 738
Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDI 471
NELI + E+ +D W N + + ++ H + ++
Sbjct: 739 NELIWLNEKEEEEVAYD--------WSERNTNIARKKDY-------------HAELMREL 777
Query: 472 AAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQ 531
EE +++V +A +L EN+ I A + + W ++L+L + Q ++ N
Sbjct: 778 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 837
Query: 532 KIFQEMLYIMDWMDEMKVLV---LSQDYGKHLLGVEDLLQK 569
+ F + D++ +K + S D + +EDL+Q+
Sbjct: 838 EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQE 878
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 310 bits (794), Expect = 1e-83
Identities = 186/411 (45%), Positives = 252/411 (61%), Gaps = 23/411 (5%)
Query: 48 LADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGR 107
+ADER+ VQKKTFTKW+N HL +V + DLY DLRDG LI LLEVLSG+ LP+ KGR
Sbjct: 69 IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGR 127
Query: 108 MRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETE 167
MR H L+NV AL +LK ++V L N+ + DI DGN +LTLGLIWTIIL FQI DI V E
Sbjct: 128 MRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 187
Query: 168 DNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKK 227
E SAK+ LLLW Q T GY + NFTT WRDG FNA+IHK+RPDLID + +
Sbjct: 188 S--EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 245
Query: 228 SNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEG 287
+ NL++AF +AE+ +G+ +LLDPED+ V PDEKS+ITYV + Y F K+ G
Sbjct: 246 QSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPE---GG 301
Query: 288 KRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTY 347
+ IG N +E K IE Y+++ + L++WI + ++ R F N+ V ++ + +
Sbjct: 302 EGIGA---NDVEV-KWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQF 356
Query: 348 RTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERE 407
+ E PPK TEK ++ L ++ + K+ +G +DI K W +L A ERE
Sbjct: 357 KETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLERE 413
Query: 408 LALRNELIRQEKLEQLARRFDRKAAMRETWL--------SENQRLVSQDNF 450
ALR E+ R E L+Q+A R R + + E L S+++RL S F
Sbjct: 414 KALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQF 464
Score = 232 bits (592), Expect = 3e-60
Identities = 340/1669 (20%), Positives = 714/1669 (42%), Gaps = 127/1669 (7%)
Query: 494 HDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY-IMDWMDEMKVLVL 552
HD+ + AR W+ L + + R +L+ L FQ+ L ++ WM + + LV
Sbjct: 3318 HDLDDVNAR-------WKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3370
Query: 553 SQDY-GKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRD 611
+Q V+ +Q+ L++ + + V + +K AT E P D I
Sbjct: 3371 NQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE---PADKVKILK 3427
Query: 612 RVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEE-EGWIREKEK-ILSSDDYGKD 669
+++ ++ ++ L A R +LE + + F E E W+ EK +++ + G
Sbjct: 3428 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3487
Query: 670 LTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDM-IAEEHFGSEKIRERIIYIREQWAN 728
+ + +++H+A ED++ + H QA+ G+ + + + ++ ++ + + +
Sbjct: 3488 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3547
Query: 729 LEQLSAIRKKRLEEASLLHQ-FQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHK 787
+++ S R + L++A + F D ++ W+ ++ +S V +YST+ L K+
Sbjct: 3548 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV--QDYSTEGLWKQQS 3605
Query: 788 DVA---EEIANYRPTLDTLHEQASALPQEHA--ESPDVRGRLSGIEERYKEVAELTRLRK 842
++ E+I + +D L ++ E ++ +L I+ RYK++ +L+
Sbjct: 3606 ELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVA 3665
Query: 843 QALQDTLALYK-MFSEADACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNN 900
+ L+ L L + + S + W+D+ E L + + K E+ Q R + L+ E N
Sbjct: 3666 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3725
Query: 901 QASRVAVVNQIARQLMHSGHPSEKE-IKAQQDKLNTRWSQFRELVDRKKDALLSA-LSIQ 958
+ + +N+++ L+ +E ++ + N R+ + + +K + + +A L Q
Sbjct: 3726 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQ 3785
Query: 959 NYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKE 1018
+ + SWI E K + S D+ + A + +++ + + DL K
Sbjct: 3786 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKS 3845
Query: 1019 AEKLESE-HPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQS 1076
K+ + ++ Q++ +L ++ ++ + R L A L QF ++
Sbjct: 3846 GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWP 3905
Query: 1077 WLSRTQTAIASEDMPNTLTEAEKLLTQ---HENIKNEIDNYEEDYQKMRDMGEMVTQGQT 1133
WL+ TQ+ I+ +P E E L Q H ++ I ++ KM G + + +
Sbjct: 3906 WLTETQSIISQ--LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE-LS 3962
Query: 1134 DAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA 1193
+ ++++ A DT ++++ + + R L ++ + D + + L + E ++
Sbjct: 3963 PGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILESLERIVE 4020
Query: 1194 HTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVET----GRRLVS-----DGNINSD 1244
P ++ IK+Q + + EK+ + ET G +++ D +I++
Sbjct: 4021 RLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 4080
Query: 1245 RIQEKVDSIDDRHRKNRETASELLMRLKDNRDL-QKFLQDCQELSLWINEKMLTAQDMSY 1303
+Q+K+D + E +L D +L +KF C +SL + K QD
Sbjct: 4081 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFW--CDHMSLIVTIK--DTQDFIR 4136
Query: 1304 D-EARNLHSKWLKHQAFMAELASNK-----EWLDKIEKEGMQLISEKPETEA-VVKEKLT 1356
D E + +K Q AE + E LD + G +LI+ E + +VK+ +
Sbjct: 4137 DLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSID 4196
Query: 1357 GLHKMWEVLESTTQTKAQRLFDANKAEL-FTQSCADLDKWLHGLESQIQS-DDYGKDLTS 1414
L+ W+ L + + +L +A +A + + + W+ ++ S G DL +
Sbjct: 4197 ELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLET 4256
Query: 1415 VNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELL--- 1471
V +++ + +++ ++ E+E L QA+ L + K T+E D TVQ MEL
Sbjct: 4257 VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK--KVTEESDKH--TVQDPLMELKLIW 4312
Query: 1472 ----EPLNERKHNLL-ASKEIHQFNRDVEDEILWVGERMPLATSTDH-GHNLQTVQLLIK 1525
E + R+H L A + QF +++ + W+ L + G + + +++ +
Sbjct: 4313 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4372
Query: 1526 KNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRH 1585
K+ LQ ++ HQ ++ + + +++ S+ A ++ +L L Q W ++E+TE+R
Sbjct: 4373 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4432
Query: 1586 RRLEEAHR-AQQYYFDAAEAEAWMSEQELYMMSEEKAKD-EQSAVSMLKKHQILEQAVED 1643
++L+ A R A+ ++ + + + W+++ E ++++ + ++A L H + A E
Sbjct: 4433 QQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4492
Query: 1644 YAETVHQLSKTSRALVADSHPESE-RISMRQSKVDKLYAGLKDLAEERRGKLDERHRL-F 1701
ET L + + ++A +E I + + + + ++ ER+ KL+E L
Sbjct: 4493 KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4552
Query: 1702 QLNREVDDLEQWIAEREV---VAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVD-- 1756
+ + + D W+ + E VA L D V + + FA + + ++ ++
Sbjct: 4553 EFHNSLQDFINWLTQAEQTLNVASRPSLILD--TVLFQIDEHKVFANEVNSHREQIIELD 4610
Query: 1757 -TVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA- 1814
T HL S D I + W +++ + R + L + + K +H+A
Sbjct: 4611 KTGTHLK---YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAW 4667
Query: 1815 KEIFGRIQDKHKKLPEEL--GRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL-- 1870
++ +++ K L EL D + ++T H F+ + A + L
Sbjct: 4668 SKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4727
Query: 1871 QAAYAGD--KADDIQKRENEVLEAWKSLLDACESRRVRLVDT-GDKFRFFSMVRDLMLWM 1927
+ + A D K DD+ +E+ + W ++ R+ +L + +F ++ L+ W+
Sbjct: 4728 KTSLADDNLKLDDML---SELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWL 4784
Query: 1928 EDVIRQI-EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASE 1986
V Q+ E Q D+ V L++NH+ + E+ R S + L+ S
Sbjct: 4785 YRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS 4844
Query: 1987 EIKEKLLQLTEKRKEMIDKWEDRWEWL---------RLILEVHQFSRDASVAEA---WLL 2034
+K ++ +L+ RWE + RL + Q SV A WL
Sbjct: 4845 WVKVQMQELS-----------TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLA 4893
Query: 2035 GQEPYLSSREI-GQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTL 2082
E L + D + LI +H+ F K +E+ + L + TT+
Sbjct: 4894 EAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL---EEKRAELNKATTM 4939
Score = 214 bits (546), Expect = 6e-55
Identities = 360/1876 (19%), Positives = 770/1876 (41%), Gaps = 157/1876 (8%)
Query: 288 KRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVG--------VQQ 339
K+ K+LD A E+ +E + +++ I+L + G + Q
Sbjct: 3214 KQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQ 3273
Query: 340 QLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERL 399
QL F ++ E P +G + + + Q +++ + + D+N W+ L
Sbjct: 3274 QLNMFKVFQKEEIEPL---QGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3330
Query: 400 EKAEHERELALRNELIR----QEKLEQLARRFDRKAAMRETWLSENQRLV-SQDNFGFDL 454
K +R L+ L+ Q+ LE L +W+ + + LV +Q +
Sbjct: 3331 NKKVAQRAAQLQEALLHCGRFQDALESLL-----------SWMVDTEELVANQKPPSAEF 3379
Query: 455 PAVEAATKKHEAIETDIAAYEERVQAVVAVARELE-----AENYHDIKRITARKDNVIRL 509
V+A ++ + ++ ++R V + RE E AE +K I + +
Sbjct: 3380 KVVKAQIQEQKLLQ---RLLDDRKSTVEVIKREGEKIATTAEPADKVK-ILKQLSLLDSR 3435
Query: 510 WEYLLELLRARRQRLE-MNLGLQKIFQEMLYIMDWMDEM-KVLVLSQDYGKHLLGVEDLL 567
WE LL R ++LE +++ Q+ + + + +W+ + K LV + G +E+ +
Sbjct: 3436 WEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQI 3495
Query: 568 QKHTLVEADIGIQAERVRGVNASAQ--KFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ 625
+H +E DI + + + Q K + E D +++ ++ + Y E+ +
Sbjct: 3496 AQHKALEDDIINHNKHLHQAVSIGQSLKVLSSRE-----DKDMVQSKLDFSQVWYIEIQE 3550
Query: 626 LAAERRARLEESRRLWKFFWE-MAEEEGWIRE---KEKILSSDDYGKDLTSVMRLLSKHR 681
+ R L+++ K F E E W+ E K LS DY + + + S+ R
Sbjct: 3551 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE--GLWKQQSELR 3608
Query: 682 AFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK--IRERIIYIREQWANLEQLSAIRKKR 739
++++ R + +QA+ G +++ ++ G E I++++ I+ ++ ++ +LS K
Sbjct: 3609 VLQEDILLRKQNVDQALLNGLELL-KQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3667
Query: 740 LEEA-SLLHQFQADADDIDAWM--LDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANY 796
LE+A L + + +++ W+ +++ + + V E ++Q+ ++ K++ +E N
Sbjct: 3668 LEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRP-KELKKEAKNN 3726
Query: 797 RPTLDTLHEQASAL----PQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALY 852
+ LD+L+E +SAL P E + ++ ERY+ V++ + + + +
Sbjct: 3727 KALLDSLNEVSSALLELVPWRAREG--LEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3784
Query: 853 KMFSEADACEL-WIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQI 911
+ F +A EL WI E E+ L + L D+ + Q + + + I
Sbjct: 3785 QQFDQAADAELSWITETEKKLMS------LGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3838
Query: 912 ARQLMHSGHP-----SEKE---IKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLE 963
L+ SGH SE+E +K + DK+ + ++ + L A S+ N E
Sbjct: 3839 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3898
Query: 964 C-NETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL 1022
E W+ E +I + + Q + + + + + + K +L
Sbjct: 3899 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3958
Query: 1023 ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEA-SKLQQFLRDLDDFQSWLSRT 1081
P + +I + ++ ++K +K R +L EA S+ QF +D L R
Sbjct: 3959 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4018
Query: 1082 QTAIASEDMPNTLTEAEKL---LTQHENIKNEIDNYEEDYQKMRDMGE--MVTQGQTDAQ 1136
+ P+ E EK+ +++++N+ +++ + Y+ ++ GE + G TD
Sbjct: 4019 VERL--RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4076
Query: 1137 Y--MFLRQRLQALDTGWNELHKMWENRQ-NLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA 1193
++ +L + W +H + E R+ LL ++F D + + + +
Sbjct: 4077 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIR 4136
Query: 1194 HTEMPTTLEGAEAAIKKQ-----EDFMTTMDANEEKINAVVETGRRLVSD-GNINSDRIQ 1247
E P G + ++ KQ E +D +E+++ V+ G L++ G + ++
Sbjct: 4137 DLEDP----GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4192
Query: 1248 EKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQD-CQELSLWIN---EKMLTAQDMSY 1303
+ +D ++ + + + +L++ QD Q + W++ K+ + +
Sbjct: 4193 KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT 4252
Query: 1304 DEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPE--TEAVVKEKLTGLHKM 1361
D + + + + F +E + ++++ + L+ + E + V++ L L +
Sbjct: 4253 D-LETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4311
Query: 1362 WEVLESTTQTKAQRLFDANKA-ELFTQSCADLDKWLHGLESQI-QSDDYGKDLTSVNILL 1419
W+ LE + +L A A F + +L WL E + + G D ++ I L
Sbjct: 4312 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIEL 4371
Query: 1420 KKQQMLENQMEVRKKEIEELQSQAQAL--SQEGKSTDEVDSKRLTVQTKFMELLEPLNER 1477
K +L+N + + +E + L S G+ + +K + ++ +LE +R
Sbjct: 4372 AKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQR 4431
Query: 1478 KHNL-LASKEIHQFNRDVEDEILWVGE-RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQ 1535
K L A ++ F+ ++ED W+ + L S G +T + + + + +
Sbjct: 4432 KQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFE 4491
Query: 1536 GHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA-HRA 1594
+ + ++ Q ++ + I Q + +LK+ W + + +R +LEEA + A
Sbjct: 4492 AKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLA 4551
Query: 1595 QQYYFDAAEAEAWMSEQELYM-MSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSK 1653
+++ + W+++ E + ++ + + + + +H++ V + E + +L K
Sbjct: 4552 MEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDK 4611
Query: 1654 TSRALVADSHPE-----SERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVD 1708
T L S + + QS+ +K+ ++ L E R D R R Q +
Sbjct: 4612 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKV---VQRLVERGRSLDDARKRAKQFHEAWS 4668
Query: 1709 DLEQWIAEREVVAGSH-ELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELIN 1767
L +W+ E E S E+ D + + + +EF + G DT N L
Sbjct: 4669 KLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLG-AKHSVYDTTNRTGRSL-- 4725
Query: 1768 SGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKK 1827
+ ++A+ L++ ++L + DT I S E +A G+ D +
Sbjct: 4726 ---KEKTSLADDNLKLDDMLSELRDKWDT---ICGKSVERQNKLEEALLFSGQFTDALQA 4779
Query: 1828 LPEELGR-------------DQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAY 1874
L + L R D + V L H F+ ++ + V+ L+ A L
Sbjct: 4780 LIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG- 4838
Query: 1875 AGDKADDIQKRENEVLEAWKSLLDACESRRVRL-VDTGDKFRFFSMVRDLMLWMEDVIRQ 1933
+ D + ++ + E+ W+++ S++ RL F S+V L+ W+ + +
Sbjct: 4839 SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQT 4898
Query: 1934 IEAQ-EKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKL 1992
+ P D ++ L++ H+ +++ + +G ++LA H S +
Sbjct: 4899 LRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHW 4958
Query: 1993 LQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAE---AWLLGQEPYLSSRE---IG 2046
+ + R E + W + + RL + + E AWL E L+ ++ I
Sbjct: 4959 ITIIRARFEEVLAWAKQHQ-QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 5017
Query: 2047 QSVDEVEKLIKRHEAF 2062
Q ++EV+ LI H+ F
Sbjct: 5018 QEIEEVKALIAEHQTF 5033
Score = 209 bits (533), Expect = 2e-53
Identities = 320/1645 (19%), Positives = 687/1645 (41%), Gaps = 105/1645 (6%)
Query: 387 KLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSE-NQRLV 445
K +S ++ WE L R L E + +A++F WL+ +RLV
Sbjct: 3427 KQLSLLDSRWEALLNKAETRNRQL-------EGISVVAQQFHETLEPLNEWLTTIEKRLV 3479
Query: 446 SQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDN 505
+ + G +E +H+A+E DI + + + V++ + L+ + + K + K +
Sbjct: 3480 NCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLD 3539
Query: 506 VIRLWEY-LLELLRARRQRLEMNLGLQKIF-QEMLYIMDWMDEM--KVLVLS-QDYGKHL 560
++W + E +R + L+ L KIF ++ + +M+W++E+ K+ LS QDY
Sbjct: 3540 FSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE- 3598
Query: 561 LGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCY 620
G+ + +++ DI ++ + V + + G + +I+D++ ++ Y
Sbjct: 3599 -GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTG---DEVLIIQDKLEAIKARY 3654
Query: 621 QELCQLAAERRARLEESRRLWKFFWEMAEEE-GWIREKE-KILSSDDYGKDLTSVMRLLS 678
+++ +L+ + LE++ +L + EE W+ + E ++LS + +
Sbjct: 3655 KDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQM 3714
Query: 679 KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 738
+ + + E + + ++ + + + E+++ + L + +K
Sbjct: 3715 RPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKV 3774
Query: 739 RLEEASLL--HQFQADADDIDAWMLDI-LKIVSSSDVGHDEYSTQSLVKKHKDVAEEIAN 795
+A++L QF AD +W+ + K++S D+ ++ T + ++ K EI
Sbjct: 3775 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3834
Query: 796 YRPTLDTL----HEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLAL 851
++ +D L H+ +A +E +S ++ +L + + Y + ++ R L+ +L
Sbjct: 3835 HKDIIDDLVKSGHKIMTACSEEEKQS--MKKKLDKVLKNYDTICQINSERYLQLERAQSL 3892
Query: 852 YKMFSEA-DACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNNQASRVAVVN 909
F E + W+ E + ++ + P + E L Q L + + +N
Sbjct: 3893 VNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMN 3952
Query: 910 QIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALS-IQNYHLECNETK 968
+ QL+ I+ + +T +SQ +E V ++ AL A+S +H + ++
Sbjct: 3953 KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 4012
Query: 969 SWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL-----E 1023
+ + + + ++ + + + D+ ++ L++ E++
Sbjct: 4013 ESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGG 4072
Query: 1024 SEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQ 1082
++ A+A+ +L ++ +WE + T ++ REA L + +L ++F D + TQ
Sbjct: 4073 TDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQ 4132
Query: 1083 TAIASEDMPNTLTEAEKLLTQ-HENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1141
I + P K + E I+ EID +E+ + ++G + + ++
Sbjct: 4133 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4192
Query: 1142 QRLQALDTGWNELHKMWENRQNLLSQS-HAYQQFLRDTKQAEAFLNNQEYVLAH-TEMPT 1199
+ + L++ W+ L+K W++R + L ++ A Q+ + +++ LA + + T
Sbjct: 4193 KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT 4252
Query: 1200 TLEGAEAAIKKQEDFMT---TMDANEEKINAVVETGRRLV---SDGNINSDRIQEKV--- 1250
LE + I++ + F + E++N E + V SD + D + E
Sbjct: 4253 DLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIW 4312
Query: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWI--NEKMLTAQDMSYDEARN 1308
DS+++R + L+ L +F EL W+ E +L+ Q + +
Sbjct: 4313 DSLEERIINRQHKLEGALLA------LGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKA 4366
Query: 1309 LHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAV-VKEKLTGLHKMWE-VLE 1366
+ + KH ++ +++ ++ + K G LI EA ++ KL L++ W+ VLE
Sbjct: 4367 IEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLE 4426
Query: 1367 STTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLE 1426
T Q K Q +A+ F DL +WL E + + K L + K+Q +
Sbjct: 4427 KTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLA---SKPLGGLPETAKEQLNVH 4483
Query: 1427 NQMEVRKKEIEE-----LQSQAQALSQEGKSTD-EVDSKRLTVQTKFMELLEPLNERKHN 1480
++ + EE +Q Q L++ KS + +D ++ K+ + LNERK
Sbjct: 4484 MEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTK 4543
Query: 1481 LLASKEI-HQFNRDVEDEILWVGE-RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQ 1538
L + + +F+ ++D I W+ + L ++ L TV I +++ E+ H+
Sbjct: 4544 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4603
Query: 1539 PRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAH-RAQQY 1597
+I ++ + ++ S I+ L ++ W +++ +R R L++A RA+Q+
Sbjct: 4604 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4663
Query: 1598 YFDAAEAEAWMSEQELYMMSE-EKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSR 1656
+ ++ W+ E E + SE E A D + L +H+ ++++ ++T R
Sbjct: 4664 HEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGR 4723
Query: 1657 ALVADSHPESERISMRQSKVDKLYAGLKD-------LAEERRGKLDERHRLF--QLNREV 1707
+L E ++ K+D + + L+D + ER+ KL+E LF Q +
Sbjct: 4724 SL-----KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEA-LLFSGQFTDAL 4777
Query: 1708 DDLEQWIAERE-VVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELI 1766
L W+ E +A + D + V L + + F ++ G V + A ELI
Sbjct: 4778 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALKRSARELI 4836
Query: 1767 NSGHSDAATIAEWKDGLNEAWADLLEL-IDTRTQILAA---SYELHKFYHDAKEIFGRIQ 1822
D++ + L+ W + L I +T++ AA + E H H E +
Sbjct: 4837 EGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAE 4896
Query: 1823 DK---HKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKA 1879
H LP+ D++ + TL H F ++ ++ + + A D
Sbjct: 4897 QTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSI 4952
Query: 1880 DDIQKRENEVLEAWKSLLDACESRRVRLVDT----GDKFRFFSMVRDLMLWMEDVIRQIE 1935
I+ + ++ +L + + RL K + + W E + +
Sbjct: 4953 TTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKD 5012
Query: 1936 AQEKPRDVSSVELLMNNHQGIKAEI 1960
+ P+++ V+ L+ HQ E+
Sbjct: 5013 KEVIPQEIEEVKALIAEHQTFMEEM 5037
Score = 162 bits (409), Expect = 5e-39
Identities = 251/1319 (19%), Positives = 543/1319 (41%), Gaps = 103/1319 (7%)
Query: 305 EKYESLASDLLEWIEQT---IIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGN 361
++++ A L WI +T ++ L + + Q Q+Q T + K
Sbjct: 3785 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR------HKDI 3838
Query: 362 LEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLE 421
++ L+ + M A +++ + KL + K ++ + + ER L L E+ +
Sbjct: 3839 IDDLVKSGHKIMTACSEEEKQSMKKKL-DKVLKNYDTICQINSERYLQL-------ERAQ 3890
Query: 422 QLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAAT-----KKHEAIETDIAAYEE 476
L +F WL+E Q ++SQ PA+E T ++H + IA ++
Sbjct: 3891 SLVNQFWETYEELWPWLTETQSIISQ----LPAPALEYETLRQQQEEHRQLRELIAEHKP 3946
Query: 477 RVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQE 536
+ + +L + + I + L+ + E ++ R L+ + F +
Sbjct: 3947 HIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 4006
Query: 537 ML-YIMDWMDEM-KVLVLSQDYGKHLLGVEDLLQKHTLVEADIG-----IQAERVRGVNA 589
+ I++ ++ + + L + +++ + ++ V D+ + + RG
Sbjct: 4007 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066
Query: 590 SAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFW---- 645
A+ TD K + ++D++ M F ++ + L ER A+L + L + FW
Sbjct: 4067 IARSGGTD----KDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHM 4122
Query: 646 ----EMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEG 701
+ + + +IR+ E D G D + V + +E+ G + I G
Sbjct: 4123 SLIVTIKDTQDFIRDLE------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLG 4176
Query: 702 EDMIAEEHFGSEKI-RERIIYIREQWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAW 759
++IA + I ++ I + W +L + R +LEEA Q+Q + W
Sbjct: 4177 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4236
Query: 760 MLDIL--KIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAES 817
+ DI K+ S S +G D + + +++ K E + ++ L+ QA L ++ E
Sbjct: 4237 V-DIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4295
Query: 818 PD---VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEA-DACELWIDEKEQWLN 873
D V+ L ++ + + E R+ L+ L F A D W+ E L+
Sbjct: 4296 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS 4355
Query: 874 NMQI----PEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE-KEIKA 928
+ P+ +E +E+ +H L+ ++ S V VN+ L+ S E ++
Sbjct: 4356 EQKPVGGDPKAIE-IELAKHHV--LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4412
Query: 929 QQDKLNTRWSQFRELVDRKKDALLSAL-SIQNYHLECNETKSWIREKTKVIESTQDLGND 987
+ + LN RW E +++K L AL + +H E + + W+ + + + +++ LG
Sbjct: 4413 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-- 4470
Query: 988 LAGVMALQRKLTGMERDL-VAIEAK---LSDLQKEAEKLESEHPDQAQAILSR-LAEISD 1042
G+ ++ + ++ A EAK L ++ +++ + P A+ + + + + +
Sbjct: 4471 --GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE 4528
Query: 1043 VWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKL- 1100
WE ++T L R+ L EA L +F L DF +WL++ + + P+ + +
Sbjct: 4529 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ 4588
Query: 1101 LTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNEL-HKMWE 1159
+ +H+ NE++++ E ++ G + + ++ L ++ + W ++ ++ E
Sbjct: 4589 IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4648
Query: 1160 NRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVL-AHTEMPTTLEGAEAAIKKQEDFMTTM 1218
++L +QF + +L E L + E+ + + + + ++F ++
Sbjct: 4649 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4708
Query: 1219 DANEEKINAVVETGRRL-----VSDGNINSD----RIQEKVDSIDDRHRKNRETASELLM 1269
A + TGR L ++D N+ D +++K D+I + + + E L+
Sbjct: 4709 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4768
Query: 1270 RLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEW 1329
D + L D L+ E L + + + + H+AF EL
Sbjct: 4769 FSGQFTDALQALIDW----LYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSS 4824
Query: 1330 LDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA-NKAELFTQS 1388
+ +++ +LI + + VK ++ L WE + + + +K RL A +AE F
Sbjct: 4825 VQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSV 4884
Query: 1389 CADLDKWLHGLESQIQSDDY-GKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALS 1447
L +WL E ++ D ++ L+ + + ++E ++ E+ + + +
Sbjct: 4885 VHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4944
Query: 1448 Q--EGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEIL-WVGER 1504
S + ++ +F E+L + + L ++ +++ + +L W+
Sbjct: 4945 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 5004
Query: 1505 MPLATSTDHG---HNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSA 1560
T D ++ V+ LI ++QT +E+ QP +D + + + D SSL +
Sbjct: 5005 ETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQS 5063
Score = 149 bits (375), Expect = 4e-35
Identities = 333/1806 (18%), Positives = 719/1806 (39%), Gaps = 200/1806 (11%)
Query: 277 FSKMKALAVEGKRIGKVLDNAIETEKMI-----EKYESLASDLLEWIEQTIIILNNRKFA 331
FSK K + E + L A++T ++ +K + LE +T+ N F+
Sbjct: 1511 FSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS 1570
Query: 332 NSLVGVQQQLQAFNTYRTV--------EKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMP 383
SL +QLQ T V E+ ++ EK L T +Q+ +M
Sbjct: 1571 ESL----KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI 1626
Query: 384 REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR 443
+G + L+K + ++E EL Q+ ++ A+ E +L EN
Sbjct: 1627 GDGTV---------ELKKYQSKQE-----EL--QKDMQGSAQALAEVVKNTENFLKENGE 1670
Query: 444 LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 503
+SQ++ + A K E + ++ + VV A + E E +K++ K
Sbjct: 1671 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESK 1730
Query: 504 DNVIRLWEYLLELLR-------ARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 556
+ L ++L + + +Q +E N G + + DE+ +L D
Sbjct: 1731 TKIENLLDWLSNVDKDSERAGTKHKQVIEQN-GTHFQEGDGKSAIGEEDEVNGNLLETDV 1789
Query: 557 -GKHLLGVEDLLQKHTLVEAD---IGIQAERVRGVNASAQ-KFATDGEGYKPCDPQVIRD 611
G+ E+L Q++ V+A I Q + V SAQ G+ P + + ++
Sbjct: 1790 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1849
Query: 612 RVAHMEFCYQELCQLAAERRARLEES--RRLWKFFWEMAEEEGWIREKEKILSSDDYG-K 668
+ ++ Y E +E++ +L S L KF + E E W+++ E+ L + + G
Sbjct: 1850 NMKELKVHY-ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1908
Query: 669 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK-------------I 715
D+ +M L + ++F +++ G G ++ S++ +
Sbjct: 1909 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 1968
Query: 716 RERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADAD-----DIDAWMLDILKIVSSS 770
+ ++ + +++ +L + L++ +Q DA + A K + S
Sbjct: 1969 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SE 2027
Query: 771 DVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAE----SPDVRGRLSG 826
+ D + Q +++ K + +I++ + ++ L + A L D++ L
Sbjct: 2028 PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDD 2087
Query: 827 IEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNM--------QIP 878
I RY+++++ R + LQ TL + S D +DE W+ N+ Q+P
Sbjct: 2088 IVGRYEDLSKSVNERNEKLQITLT--RSLSVQDG----LDEMLDWMGNVESSLKEQGQVP 2141
Query: 879 EKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWS 938
L+ I + LE ++ + S + +N+ ++ M + PS + Q K+ +
Sbjct: 2142 LNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPS--TASSLQAKMKDLSA 2199
Query: 939 QFRELVDRKKDALLS----ALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMAL 994
+F E + K+ L ++ + + ++++ KT+ + G D+ +
Sbjct: 2200 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2259
Query: 995 QRKLTGMERDLVAIEAKLSDLQKEAEKLESEH-PDQAQAILSRLAEISDVWEEMKTTLK- 1052
++ T + + + L L +++ S P +L + +S ++EM+ T+K
Sbjct: 2260 MQESTS---EFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2316
Query: 1053 NREASLGEASKLQQFLRDLDDFQSWLSRT-------QTAIASEDMPNTLTEAEKLLTQHE 1105
+EA +L F + +SW+ T Q + +ED+ +L + +KL +
Sbjct: 2317 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWS 2376
Query: 1106 NIKNEIDNYEEDYQKMRDMG----EMVTQGQTDAQYMFLRQRLQALDTG---WNELHKMW 1158
EI QK+ + G +++ T A+ + + A+ G + W
Sbjct: 2377 LKTPEI-------QKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2429
Query: 1159 EN------RQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVL-------------------- 1192
N ++++ SH Y+ K A LN + L
Sbjct: 2430 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT 2489
Query: 1193 ----AHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDG--NINSDRI 1246
T PT E + +++ + F + N K+ + + L+ + + R
Sbjct: 2490 ATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW 2549
Query: 1247 QEKVDSIDDRHRKNRETASELLMRLKD-NRDLQKFLQDCQELSLWINEKMLTAQ---DMS 1302
++ + ID + ++ + + +L++ + +L +F +L W+ EK L +S
Sbjct: 2550 KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLS 2609
Query: 1303 YDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLIS---EKPETEAVVKEKLTGLH 1359
D L+++ + Q + E A+ K +++ G ++S E P +VKE+L +
Sbjct: 2610 ID-PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2668
Query: 1360 KMWEVLESTTQTKAQRLFDA-NKAELFTQSCADLDKWLHGLESQIQSD-DYGKDLTSVNI 1417
+ W+ L + + A K+ + L L L++++ S ++N
Sbjct: 2669 QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ 2728
Query: 1418 LLKKQQMLENQMEVRKKEIEELQSQAQ---ALSQEGKSTDEVDSKRLTVQTKFMELLEPL 1474
L+ Q ++ +++ KK+I+ Q+ + AL +E E+ + + F ++ +
Sbjct: 2729 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKA 2788
Query: 1475 -NERKHNLLASKEIHQFNRDVEDEILWVG-ERMPLATSTDHGHNLQTVQLLIKKNQTLQK 1532
N +H A HQF + D W+ ++ S L ++ LIK ++ K
Sbjct: 2789 ENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2848
Query: 1533 EIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA- 1591
+ + +N++ + A++ +L +K W ++ ++R +L+E+
Sbjct: 2849 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 2908
Query: 1592 HRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQL 1651
+A +Y W+ + + + + D + + K + L++ ++ + V L
Sbjct: 2909 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELL 2968
Query: 1652 SKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREV--DD 1709
+ T+ +L++ + E ++ + + + + ++ L+ + F+ +EV +
Sbjct: 2969 NNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 3028
Query: 1710 LEQWIAEREVVAGSHELG-QDY--EHVTMLQERFREFARDTGNIGQERVDTVNHLADELI 1766
Q +E + LG Q Y +++TMLQ + + + +VD LA +L+
Sbjct: 3029 KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSL-----QALKHQVDLAKRLAQDLV 3083
Query: 1767 -----NSGHSD----AATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEI 1817
+ G SD TIA+ L++ + ++T+ Q + F + +E+
Sbjct: 3084 VEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQ------GIGHFQNTIREM 3137
Query: 1818 FGRIQDKHKKLPE--ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYA 1875
F + + +L +GRD T++ + F ++AL + + A
Sbjct: 3138 FSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA--T 3195
Query: 1876 GDKADDIQ--KRENEVL-EAWKSLLDACESRRVRLVDTGDKF-RFFSMVRDLMLWMEDVI 1931
+ + D+ KR+ E L + LLD ++R ++ T + F+S +++ + ++
Sbjct: 3196 EETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE 3255
Query: 1932 RQIEAQ 1937
E+Q
Sbjct: 3256 EHEESQ 3261
Score = 137 bits (345), Expect = 1e-31
Identities = 280/1593 (17%), Positives = 637/1593 (39%), Gaps = 158/1593 (9%)
Query: 158 QIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNAL------ 211
Q+ I ++ + + + + AL C K G V + N+ D ++ ++
Sbjct: 3542 QVWYIEIQEKSHSRSELLQQAL---CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3598
Query: 212 -IHKHRPDLIDFDK---LKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSII 267
+ K + +L + L+K N L N L +Q G L+ + +
Sbjct: 3599 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEA--------- 3649
Query: 268 TYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNN 327
+ Y +K+ + K L+ A++ + + S +L W+++ + L +
Sbjct: 3650 --IKARYKDITKLST------DVAKTLEQALQ---LARRLHSTHEELCTWLDKVEVELLS 3698
Query: 328 RKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKV-YMPREG 386
+ ++ ++ QA + ++K K N + LL ++ A + V + REG
Sbjct: 3699 --YETQVLKGEEASQAQMRPKELKKEAK-----NNKALLDSLNEVSSALLELVPWRAREG 3751
Query: 387 --KLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR- 443
K++++ N+ + + ++ + ++R ++ FD+ A +W++E ++
Sbjct: 3752 LEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ-------FDQAADAELSWITETEKK 3804
Query: 444 LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 503
L+S + + A + + +I +++ + +V ++ + K+ +K
Sbjct: 3805 LMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKK 3864
Query: 504 -DNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY-IMDWMDEMKVLVLSQDYGKHLL 561
D V++ ++ + ++ R +LE L F E + W+ E + ++ L
Sbjct: 3865 LDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSII--SQLPAPAL 3922
Query: 562 GVEDLLQK---HTLVEADIGIQAERVRGVNASAQKFA--TDGEGYKPCDPQVIRDRVAHM 616
E L Q+ H + I + +N + + + GEG+ I+++
Sbjct: 3923 EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS------IQEKYVAA 3976
Query: 617 EFCYQELCQLAAERRARLEESRRLWKFFWEMAEE--EGWIREKEKILSSDDYGKDLTSVM 674
+ Y ++ + +R L+E+ F + ++ E R E++ ++ +
Sbjct: 3977 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 4036
Query: 675 RLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIA-----EEHFGSEKIRERIIYIREQWANL 729
+S+++ +M +E + GE+MIA ++ ++ +++++ + W N+
Sbjct: 4037 EQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI 4096
Query: 730 EQLSAIRK-KRLEEASLLHQFQADADDIDAWMLDILKIVSS-SDVGHDEYSTQSLVKKHK 787
L R+ K L+ L +F D + + D + D G D + + +
Sbjct: 4097 HTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4156
Query: 788 DVAEEIANYRPTLDTLHEQASALPQEHAE--SPDVRGRLSGIEERYKEVAELTRLRKQAL 845
+ EEI + LD + S L E P V+ + + + + + + R L
Sbjct: 4157 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4216
Query: 846 QDTLALYKMFSEA-DACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASR 904
++ + + + A W+D L +M DLE ++ + E L+ Q
Sbjct: 4217 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT--DLETVKQQIEELK-----QFKS 4269
Query: 905 VAVVNQIARQ-LMHSGHPSEKEIKAQQDK---------LNTRWSQFRELVDRKKDALLSA 954
A QI + L H K++ + DK L W E + ++ L A
Sbjct: 4270 EAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4329
Query: 955 L-SIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLS 1013
L ++ + +E +W+ ++ + +G D + K ++ D++A ++ +
Sbjct: 4330 LLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVE 4389
Query: 1014 DLQKEAEKL-ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASL-GEASKLQQFLRDL 1071
+ K L ES ++A + ++L ++ W+ + + R+ L G + + F ++
Sbjct: 4390 AVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEI 4449
Query: 1072 DDFQSWLSRTQT-AIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV-- 1128
+D Q WL+ T+ +AS+ + A++ L H + + EE Y+ + G+ +
Sbjct: 4450 EDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLA 4509
Query: 1129 -----TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSH-AYQQFLRDTKQAE 1182
+ D L+++ ++++T NE E NL + H + Q F+ QAE
Sbjct: 4510 RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4569
Query: 1183 AFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRL-VSDGNI 1241
LN + L+ I + + F ++++ E+I + +TG L
Sbjct: 4570 QTLN------VASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQ 4623
Query: 1242 NSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK-FLQDCQELSLWI--NEKMLTA 1298
+ I+ + S+ R K + E L D R K F + +L W+ +EK L +
Sbjct: 4624 DVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDS 4683
Query: 1299 QDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVK--EKLT 1356
+ ++ + ++ +H+ F L + D + G L + + +K + L+
Sbjct: 4684 ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLS 4743
Query: 1357 GLHKMWEVLESTTQTKAQRLFDANK-AELFTQSCADLDKWLHGLESQIQSDD--YGKDLT 1413
L W+ + + + +L +A + FT + L WL+ +E Q+ D +G D+
Sbjct: 4744 ELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DID 4802
Query: 1414 SVNILLKKQQMLENQMEVRKKEIEELQSQAQAL---SQEGKSTDEVDSKRLTVQTKFMEL 1470
V L+ + + ++ R ++ L+ A+ L S++ S +V + L+ + + +
Sbjct: 4803 LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCA 4862
Query: 1471 LEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHG---HNLQTVQLLIKKN 1527
L ++++ A ++ +F+ V + W+ E T HG + ++ LI ++
Sbjct: 4863 LS-ISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQ--TLRFHGVLPDDEDALRTLIDQH 4919
Query: 1528 QTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRR 1587
+ K+++ + ++ ++ S I+ + ++ + ++ ++ +R
Sbjct: 4920 KEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQR 4979
Query: 1588 LEEAHRAQQYYFDAAEAE-AWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAE 1646
L A + EA AW+ E + ++K +++ Q +E+
Sbjct: 4980 LASALAGLIAKQELLEALLAWLQWAETTLTDKDK--------------EVIPQEIEEV-- 5023
Query: 1647 TVHQLSKTSRALVADSHPESERISMRQSKVDKL 1679
+AL+A+ E ++ +Q VDK+
Sbjct: 5024 ---------KALIAEHQTFMEEMTRKQPDVDKV 5047
Score = 130 bits (326), Expect = 2e-29
Identities = 345/1826 (18%), Positives = 720/1826 (39%), Gaps = 221/1826 (12%)
Query: 359 KGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQE 418
K EVLL S + A N K + DI +E L K+ +ER L+ L R
Sbjct: 2061 KKTAEVLLDARGSLLPAKNDIQ------KTLDDIVGRYEDLSKSVNERNEKLQITLTRSL 2114
Query: 419 KLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERV 478
++ D M + + L Q + A++ K+ +E DIA + +
Sbjct: 2115 SVQ------DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSI 2168
Query: 479 QAV------------VAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEM 526
A+ + A L+A+ +K ++AR + L + + ++E+
Sbjct: 2169 NAMNEKVKKFMETTDPSTASSLQAK----MKDLSARFSEASHKHKETLAKMEELKTKVEL 2224
Query: 527 NLGLQKIFQEMLYIMDWMDEMKVLVLSQDY--GKHLLGVEDLLQKHTLVEADIGIQAERV 584
L + Q L E K L++ GK + + +Q+ T ++ + +
Sbjct: 2225 FENLSEKLQTFL-------ETKTQALTEVDVPGKDVTELSQYMQEST---SEFLEHKKHL 2274
Query: 585 RGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFF 644
+++ ++ ++ G P D ++ ++ ++ ++E+ E++ + + F
Sbjct: 2275 EVLHSLLKEISSHG---LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2331
Query: 645 WEMAEE-EGWIREKEKIL-------SSDDYGKDLTSVMRLLSKHRAFEDEMS--GRSG-- 692
+ + + WI+E K + ++D GK L +L K E+ SG
Sbjct: 2332 QVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGIS 2391
Query: 693 --HFEQAIKEGEDMIAEEHFGSEKIRER--IIYIREQWAN----------------LEQL 732
+ A+ IA G + E WAN E L
Sbjct: 2392 LCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDL 2451
Query: 733 SAIRKKRLEEA----SLLHQFQADADDIDAWMLDILKIVSS---SDVGHDEYSTQSLVKK 785
+ K ++ E S L + Q ++ + W+ + K + + D + ++ V++
Sbjct: 2452 GLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQ 2511
Query: 786 HKDVAEEIANYRPTLDTLHEQASALPQEHAESPDV---RGRLSGIEERYKEVAELTRLRK 842
+K E+ + L ++ + L +E+ ++P+ + L+ I+ +++E+ +LT R+
Sbjct: 2512 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2571
Query: 843 QALQDTLALYKMFSEADA-CELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEM-NN 900
Q L+++ F +A + W+ EKE ++ L L S++P M N
Sbjct: 2572 QKLEESSNNLTQFQTVEAQLKQWLVEKELMVS------VLGPL--------SIDPNMLNT 2617
Query: 901 QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFREL----------VDRKKDA 950
Q +V QI Q + P +++ A + +R + L V +K D+
Sbjct: 2618 QRQQV----QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2673
Query: 951 LLSALS-----IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDL 1005
L LS I ++ + +S +R + + DL N L+ +A+ M + L
Sbjct: 2674 LTGQLSDRCDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVSTHPDAMNQQL 2730
Query: 1006 VAIEAKLSDLQKEAEKLESEHP-----------DQAQAILSR-----LAEISDVWEEMKT 1049
+ ++Q+E ++++ + +A LSR L DV ++ +
Sbjct: 2731 ETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2790
Query: 1050 TLKNREASLGEASKLQQFLRDLDDFQSWL-SRTQTAIASEDMPNTLTEAEKLLTQHENIK 1108
+++ +++ + + QQ RD FQ+WL ++ + S + L E L+ H++
Sbjct: 2791 HVQHLQSACASSHQFQQMSRD---FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2847
Query: 1109 NEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQS 1168
+ Y+K GE + ++ L+ +L + T W+ +K + R+N L +S
Sbjct: 2848 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES 2907
Query: 1169 HAYQQFLRDTKQAEAF-------LNNQEYVLAHTEMPTTLEGAEA--AIKKQEDFMTTMD 1219
++ L+ +Q E NN E E+ L+ AE +I K + MD
Sbjct: 2908 --LEKALKYKEQVETLWPWIDKCQNNLE------EIKFCLDPAEGENSIAKLKSLQKEMD 2959
Query: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQ-------EKVDSIDDRHRKNRETASELLMRLK 1272
+ + + T L+S I+ + + +KVD + ++ + + + K
Sbjct: 2960 QHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3019
Query: 1273 DNRDLQKFLQ---DCQELSLWINEKM----LTAQDMSYDEARNLHSKWLKHQAFMAELAS 1325
+ +++ K + C + L I++ + + + ++ + + + LKHQ +A+ +
Sbjct: 3020 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3079
Query: 1326 NKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL--FDANKAE 1383
++ + +G + + ET + ++ + L + + S +TK Q + F E
Sbjct: 3080 QDLVVEASDSKGTSDVLLQVET---IAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIRE 3136
Query: 1384 LFTQSCADLDKWLHGLES-QIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ 1442
+F+Q A+ D L + ++ K ++ LKK + L + K + +
Sbjct: 3137 MFSQ-FAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM--- 3192
Query: 1443 AQALSQEGKSTDEVDSKR--LTVQTKFMELLEPLNERKHNLLAS-KEIHQFNRDVED-EI 1498
L+ E S D V KR + + +LL+ R+ + + K + +F +++ I
Sbjct: 3193 ---LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI 3249
Query: 1499 LWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQK-EIQGHQPRIDDIFERSQNIVTDSS- 1556
L + G +T+ + + QK EI+ Q + D+ Q ++ ++
Sbjct: 3250 LLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK 3309
Query: 1557 SLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEA-EAWMSEQELYM 1615
S S + + L D+ W L ++ +R +L+EA + DA E+ +WM + E +
Sbjct: 3310 STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV 3369
Query: 1616 MSEEKAKDEQSAV-SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHP-ESERISMRQ 1673
+++ E V + +++ ++L++ ++D TV + + + + P + +I +
Sbjct: 3370 ANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQL 3429
Query: 1674 SKVDKLYAGLKDLAEERRGKLDERHRLF-QLNREVDDLEQWIAEREV-VAGSHELGQDYE 1731
S +D + L + AE R +L+ + Q + ++ L +W+ E + +G
Sbjct: 3430 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3489
Query: 1732 HVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLL 1791
+ + + D N + V+ + S D + D + ++
Sbjct: 3490 KLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3549
Query: 1792 ELIDTRTQIL-AASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHT--- 1847
E +R+++L A F D E+ + + H KL + +D +T E L + +
Sbjct: 3550 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYST-EGLWKQQSELR 3608
Query: 1848 TFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRL 1907
+ DI V Q + L GD+ IQ + + +K + L
Sbjct: 3609 VLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3668
Query: 1908 VDTGD-KFRFFSMVRDLMLWMEDVIRQIEAQE----KPRDVSSVEL----LMNNHQGIKA 1958
R S +L W++ V ++ + E K + S ++ L + KA
Sbjct: 3669 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3728
Query: 1959 EIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMI-DKWEDRWEWL-RLI 2016
+D+ N E+ +LL + + E EK++ +R ++ D + E + I
Sbjct: 3729 LLDSLN-------EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3781
Query: 2017 LEVHQFSRDASVAEAWLLGQEPYLSS 2042
L QF + A +W+ E L S
Sbjct: 3782 LRSQQFDQAADAELSWITETEKKLMS 3807
Score = 104 bits (260), Expect = 9e-22
Identities = 330/1756 (18%), Positives = 665/1756 (37%), Gaps = 240/1756 (13%)
Query: 627 AAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTS-VMRLLSKHRAFED 685
AAE +L E++ + EEE I +K I + K S V A ED
Sbjct: 1223 AAEALVKLYETK--------LCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALED 1274
Query: 686 EMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASL 745
E+ ++ K ++ + + EK + + E+W N+ R + LE
Sbjct: 1275 ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLV----ERWQNVHVQIDNRLRDLEGIGK 1330
Query: 746 LHQFQADA-DDIDAWMLDI----LKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTL 800
++ D +D W+ + KI + +TQ + + K + EI + +
Sbjct: 1331 SLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ--LNQQKMLVSEIEMKQSKM 1388
Query: 801 DTLHEQAS-----------------ALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQ 843
D + A A+ +SP R R+ + + R R
Sbjct: 1389 DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYT 1448
Query: 844 ALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE--------VIQHRFESLE 895
AL + Y F+ L +EK + EK ++L+ ++ ++ +
Sbjct: 1449 ALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGK 1508
Query: 896 PEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKL-NTRWSQFRELVDRKKDALLSA 954
P + Q ++ QL + + + DK+ + ++ + V +++
Sbjct: 1509 PPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL 1568
Query: 955 LSIQNYHLECNETKSWIREKTKVI-ESTQDLGNDLAGVMALQRKLTGMERDLVAIE---- 1009
S L+ ++T ++ + K++ E Q+ L G+ L LT E L+ +
Sbjct: 1569 FSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDL---LTQTENRLIGHQEAFM 1625
Query: 1010 -----AKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEAS-- 1062
+L Q + E+L+ + AQA+ + + +E L + +L E
Sbjct: 1626 IGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLN 1685
Query: 1063 ----KLQQFLRDLDDFQSWLSRTQTAIASEDMPNT--LTEAEKLLTQHENIKNEIDNYEE 1116
K +Q + + L + T E+ + + E+ T+ EN+ + + N ++
Sbjct: 1686 EAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDK 1745
Query: 1117 DYQKMRDMG-EMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFL 1175
D ++ +++ Q T Q + + D L + + Q +Q + QQ+
Sbjct: 1746 DSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQ 1805
Query: 1176 RDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRL 1235
+ Q E ++ + V+ T+ A+ ++KQ +++ EEK
Sbjct: 1806 KVKAQHEKIISQHQAVIIATQ------SAQVLLEKQGQYLSP----EEK----------- 1844
Query: 1236 VSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDN--RDLQKFLQDCQELSLWI-- 1291
+++Q+ + + H + SE M+L + +L+KF D E W+
Sbjct: 1845 --------EKLQKNMKELKV-HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQ 1895
Query: 1292 NEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE-------- 1343
+E+ L + D+ L +K + ++F ++ S+K L I G +++
Sbjct: 1896 SEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRD 1955
Query: 1344 --KPETEAV---VKEKLTGLHKMWEVLESTTQTKAQRLFD-ANKAELFTQSCADLDKWLH 1397
K +T A V+ KL + L S L D +K + + + L L
Sbjct: 1956 GGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQ 2015
Query: 1398 GLE---SQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKST- 1453
E S+ S+ D ++ L++ + L+ Q+ ++ +E+L+ A+ L S
Sbjct: 2016 ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLL 2075
Query: 1454 ---DEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEIL-WVGE-RMPLA 1508
+++ + ++ +L + +NER L + +D DE+L W+G L
Sbjct: 2076 PAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 2135
Query: 1509 TSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLA 1568
N +Q +I KN L+++I G Q I+ + E+ + + + +A +++ ++
Sbjct: 2136 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 2195
Query: 1569 DLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSE----EKAKDE 1624
DL + + ++ ++EE + + + +E E + ++E K E
Sbjct: 2196 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 2255
Query: 1625 QSAVSMLKKHQILEQAVEDYAETVHQLSK--TSRALVADSHPESERISMRQSKVDKLYAG 1682
S + LE + + E +H L K +S L +D + + + + K +
Sbjct: 2256 LSQYMQESTSEFLEH--KKHLEVLHSLLKEISSHGLPSD----KALVLEKTNNLSKKFKE 2309
Query: 1683 LKDLAEERRGKLDE-RHRLFQLNREVDDLEQWIAER-------EVVAGSHELGQDYEHVT 1734
++D +E++ + + +L V L+ WI E + G+ +LG+ E
Sbjct: 2310 MEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTK 2369
Query: 1735 MLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDG---LN-EAWADL 1790
LQE++ + + + N LI++ + A IA K G LN E A
Sbjct: 2370 KLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGAVLNGEGTATN 2424
Query: 1791 LELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVET-------LQ 1843
E + + ++ H +++ ++DK +L +L + Q E LQ
Sbjct: 2425 TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQ 2484
Query: 1844 RMHTTFEH--------DIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLE---- 1891
+M+ T D +A+ TQV Q + A L+ +K +++ + E+LE
Sbjct: 2485 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNV--NKVQELKDKLTELLEENPD 2542
Query: 1892 -----AWKSLLDACES-----------RRVRLVDTGDKFRFFSMVR-DLMLWM-EDVIRQ 1933
WK +L +S R+ +L ++ + F V L W+ E +
Sbjct: 2543 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2602
Query: 1934 IEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASE---EIKE 1990
D + + Q + E R + G+ +L+R +KE
Sbjct: 2603 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2662
Query: 1991 KLLQLTEKRKEMIDKWEDRWEWL-RLILEVHQFSR------------DASVAEAWLLGQE 2037
+L +T+K + + DR +W+ + I++ Q+ D ++ + +
Sbjct: 2663 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2722
Query: 2038 P------YLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLE----LLE 2086
P +++++ Q + + +K IK +A E +A E + E LE +
Sbjct: 2723 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2782
Query: 2087 VRRQQEEEERKRRPPSPEPSTKVSEEAESQQQW-DTSKGEQVSQNGLPAEQGSPRMAETV 2145
Q+ E + + S + + + Q W DT K EQ + + A+ +
Sbjct: 2783 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAK---------L 2833
Query: 2146 DTSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLN 2205
D E + K+ S + S KT ++ L +TQ + A ++ LN
Sbjct: 2834 DVLESL------IKDHKDFSKTLTAQSHMYEKTIAEGEN---LLLKTQGSEKAALQLQLN 2884
Query: 2206 R-KHEWEAHNKKASSR 2220
K W+ NK+ R
Sbjct: 2885 TIKTNWDTFNKQVKER 2900
Score = 98.6 bits (244), Expect = 6e-20
Identities = 318/1721 (18%), Positives = 645/1721 (37%), Gaps = 318/1721 (18%)
Query: 514 LELLRARRQRLEMNLGLQKIFQE---MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDLL 567
L+L++ R+ L+ +L Q + +E M ++ D W+DEM+V + ++G L VE L
Sbjct: 619 LKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHL 678
Query: 568 QKHTLV-----EADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQE 622
+ H V E + ++ ++ + +A T E ++ +E Y +
Sbjct: 679 ENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAE------------KLHRLESQYAK 726
Query: 623 LCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRA 682
L + + L+ L F E W+ EKE+ + D+ + T++ R H
Sbjct: 727 LLNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAE 783
Query: 683 FEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEE 742
E+ + + + + E ++ E H I ++ QW+ + QL ++ ++E
Sbjct: 784 LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKE 843
Query: 743 ASLLHQFQADADDIDAWMLDILKIVS---SSDVGHDEYSTQSLVKKHKDVAEEIANYRPT 799
+ +F DA + ++ ++ + S D + + LV++ + EE+ Y+ T
Sbjct: 844 NTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKST 903
Query: 800 LDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEAD 859
+ L +A + Q ++ R + T + +A+ D + + D
Sbjct: 904 IANLMGKAKTIIQ--------------LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDD 949
Query: 860 ACELWID-EKEQWL------NNMQIP-----------EKLEDLEVIQHRFESL------- 894
C L + + +W N +P E ++ I+ +++++
Sbjct: 950 ECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHES 1009
Query: 895 EPEMNNQASRVAVVNQIARQLMHSGHPSEKEI--KAQQDKLNTRWSQFRE-LVDRKKDAL 951
M + S ++N+I R + S S K + Q L+ S+F + L D ++ +
Sbjct: 1010 HINMKSVVSWHYLINEIDR-IRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQV 1068
Query: 952 LSALSIQNYHLECNETKSWIREKTKVIESTQD----LGNDLAGVMALQRKL--------- 998
S I E N K + +E K E + ++ V ++ +L
Sbjct: 1069 FSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIR 1128
Query: 999 ---TGMERD----LVAIEAKLSDLQKEAEKLESE---HPDQAQAILSRLAEISDV---WE 1045
T +ERD V + L+KE E+L+ + ++ + S+ A S V
Sbjct: 1129 QIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRS 1188
Query: 1046 EMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNT-LTEAEKLLTQH 1104
E+ L+N +S ++ L L TQ A A + T L E E ++
Sbjct: 1189 ELNVVLQNMNQVYSMSS---TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK 1245
Query: 1105 ENIKN----------EIDN-------YEEDYQKMRDMGEMV--TQGQTDAQYMFLRQRLQ 1145
NI+N E+D E++ QK + + + + T + D + + +++
Sbjct: 1246 NNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD 1305
Query: 1146 ALDTGWNELHKMWENRQNLLSQSHAYQQFLRDT--------------------------K 1179
L W +H +NR L ++ RDT K
Sbjct: 1306 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSK 1365
Query: 1180 QAEAFLNNQEYVLAHTEMPTT--------LEGAEAAIKKQE----DFMTTMDANEE---- 1223
LN Q+ +++ EM + E A +K E + +D+ ++
Sbjct: 1366 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVK 1425
Query: 1224 --------------------KINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRET 1263
+ A+V + + + R++E+ S+++ +++ E
Sbjct: 1426 RRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEK 1485
Query: 1264 ASEL-------LMRLKDNRDLQKFLQDCQELSL--------WINEKMLTAQ-------DM 1301
A EL LKD K Q++S ++E + T Q D
Sbjct: 1486 AKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDK 1545
Query: 1302 SYDEARNLHSKWLK--HQAFMAELASNKEWLDKIEKEGMQLISEK--PETEAVVKEKLTG 1357
DE RN K +K +++ + + + L + + G + EK E + KEKL G
Sbjct: 1546 MTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQG 1605
Query: 1358 LHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNI 1417
+ + TQT+ RL +A + +L K+ + ++Q D G +
Sbjct: 1606 ------ICDLLTQTE-NRLIGHQEAFMIGDGTVELKKY-QSKQEELQKDMQGSAQALAEV 1657
Query: 1418 LLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFME------LL 1471
+ + L K+ E+L + +AL ++ + ++ ++L ++ + + +
Sbjct: 1658 VKNTENFL-------KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1710
Query: 1472 EPLNERKHNLLASKEIHQFNRDVEDEILWVG--ERMPLATSTDHGHNLQTVQLLIKKNQT 1529
+ E + A K++ + +E+ + W+ ++ T H + +I++N T
Sbjct: 1711 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH-------KQVIEQNGT 1763
Query: 1530 LQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLE 1589
+E G + I + E + N++ ++ L Q + + +H ++
Sbjct: 1764 HFQEGDG-KSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQ-------KVKAQHEKII 1815
Query: 1590 EAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVH 1649
H+A A+ + +Q Y+ EEK K +++ + ++ E + H
Sbjct: 1816 SQHQA--VIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTH 1873
Query: 1650 QLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDD 1709
L + AD + + +++ L AG D+ + +L R+
Sbjct: 1874 SLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDI----------NGLMTKLKRQKSF 1923
Query: 1710 LEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSG 1769
E I+ + D ++T+ R E A+ +VDT
Sbjct: 1924 SEDVISHK----------GDLRYITISGNRVLEAAKSCSKRDGGKVDT------------ 1961
Query: 1770 HSDAATIAEWKDGLNEAWADLLELIDTRTQILAAS----YELHKFYHDAK-EIFGRIQ-- 1822
+AT E + L+ A D + ++ +L + + ++ Y DA + +Q
Sbjct: 1962 ---SATHREVQRKLDHA-TDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQAC 2017
Query: 1823 --DKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAG--DK 1878
K L E + D ++ + I + V +L++ A L A
Sbjct: 2018 EATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPA 2077
Query: 1879 ADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLML-WMEDVIRQIEAQ 1937
+DIQK ++++ ++ L + R +L T + D ML WM +V ++ Q
Sbjct: 2078 KNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ 2137
Query: 1938 EKP-------RDVSSVELLMNNH-QGIKAEIDARNDSFTTCIELG------------KSL 1977
+ +D+ S +++ G ++ I+A N+ +E K L
Sbjct: 2138 GQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2197
Query: 1978 LARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILE 2018
AR AS + KE L ++ E+ K ++ +E+ E L+ LE
Sbjct: 2198 SARFSEASHKHKETLAKM-EELKTKVELFENLSEKLQTFLE 2237
Score = 53.1 bits (126), Expect = 3e-06
Identities = 52/281 (18%), Positives = 116/281 (41%), Gaps = 28/281 (9%)
Query: 293 VLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAF-NTYRTVE 351
+LD + E++ K+ DLL W+++ + L+ ++ + L V+ L+ N +R +E
Sbjct: 633 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 689
Query: 352 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 411
+ ++ + + T K+ + + + + + ++ ER H
Sbjct: 690 EFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRAT 749
Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDI 471
NELI + E+ +D W N + + ++ H + ++
Sbjct: 750 NELIWLNEKEEEEVAYD--------WSERNTNIARKKDY-------------HAELMREL 788
Query: 472 AAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQ 531
EE +++V +A +L EN+ I A + + W ++L+L + Q ++ N
Sbjct: 789 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 848
Query: 532 KIFQEMLYIMDWMDEMKVLV---LSQDYGKHLLGVEDLLQK 569
+ F + D++ +K + S D + +EDL+Q+
Sbjct: 849 EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQE 889
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 310 bits (794), Expect = 1e-83
Identities = 186/411 (45%), Positives = 252/411 (61%), Gaps = 23/411 (5%)
Query: 48 LADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGR 107
+ADER+ VQKKTFTKW+N HL +V + DLY DLRDG LI LLEVLSG+ LP+ KGR
Sbjct: 207 IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGR 265
Query: 108 MRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETE 167
MR H L+NV AL +LK ++V L N+ + DI DGN +LTLGLIWTIIL FQI DI V E
Sbjct: 266 MRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 325
Query: 168 DNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKK 227
E SAK+ LLLW Q T GY + NFTT WRDG FNA+IHK+RPDLID + +
Sbjct: 326 S--EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 383
Query: 228 SNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEG 287
+ NL++AF +AE+ +G+ +LLDPED+ V PDEKS+ITYV + Y F K+ G
Sbjct: 384 QSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPE---GG 439
Query: 288 KRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTY 347
+ IG N +E K IE Y+++ + L++WI + ++ R F N+ V ++ + +
Sbjct: 440 EGIGA---NDVEV-KWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQF 494
Query: 348 RTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERE 407
+ E PPK TEK ++ L ++ + K+ +G +DI K W +L A ERE
Sbjct: 495 KETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLERE 551
Query: 408 LALRNELIRQEKLEQLARRFDRKAAMRETWL--------SENQRLVSQDNF 450
ALR E+ R E L+Q+A R R + + E L S+++RL S F
Sbjct: 552 KALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQF 602
Score = 232 bits (592), Expect = 3e-60
Identities = 340/1669 (20%), Positives = 714/1669 (42%), Gaps = 127/1669 (7%)
Query: 494 HDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY-IMDWMDEMKVLVL 552
HD+ + AR W+ L + + R +L+ L FQ+ L ++ WM + + LV
Sbjct: 3456 HDLDDVNAR-------WKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3508
Query: 553 SQDY-GKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRD 611
+Q V+ +Q+ L++ + + V + +K AT E P D I
Sbjct: 3509 NQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE---PADKVKILK 3565
Query: 612 RVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEE-EGWIREKEK-ILSSDDYGKD 669
+++ ++ ++ L A R +LE + + F E E W+ EK +++ + G
Sbjct: 3566 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3625
Query: 670 LTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDM-IAEEHFGSEKIRERIIYIREQWAN 728
+ + +++H+A ED++ + H QA+ G+ + + + ++ ++ + + +
Sbjct: 3626 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3685
Query: 729 LEQLSAIRKKRLEEASLLHQ-FQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHK 787
+++ S R + L++A + F D ++ W+ ++ +S V +YST+ L K+
Sbjct: 3686 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV--QDYSTEGLWKQQS 3743
Query: 788 DVA---EEIANYRPTLDTLHEQASALPQEHA--ESPDVRGRLSGIEERYKEVAELTRLRK 842
++ E+I + +D L ++ E ++ +L I+ RYK++ +L+
Sbjct: 3744 ELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVA 3803
Query: 843 QALQDTLALYK-MFSEADACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNN 900
+ L+ L L + + S + W+D+ E L + + K E+ Q R + L+ E N
Sbjct: 3804 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3863
Query: 901 QASRVAVVNQIARQLMHSGHPSEKE-IKAQQDKLNTRWSQFRELVDRKKDALLSA-LSIQ 958
+ + +N+++ L+ +E ++ + N R+ + + +K + + +A L Q
Sbjct: 3864 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQ 3923
Query: 959 NYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKE 1018
+ + SWI E K + S D+ + A + +++ + + DL K
Sbjct: 3924 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKS 3983
Query: 1019 AEKLESE-HPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQS 1076
K+ + ++ Q++ +L ++ ++ + R L A L QF ++
Sbjct: 3984 GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWP 4043
Query: 1077 WLSRTQTAIASEDMPNTLTEAEKLLTQ---HENIKNEIDNYEEDYQKMRDMGEMVTQGQT 1133
WL+ TQ+ I+ +P E E L Q H ++ I ++ KM G + + +
Sbjct: 4044 WLTETQSIISQ--LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE-LS 4100
Query: 1134 DAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA 1193
+ ++++ A DT ++++ + + R L ++ + D + + L + E ++
Sbjct: 4101 PGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILESLERIVE 4158
Query: 1194 HTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVET----GRRLVS-----DGNINSD 1244
P ++ IK+Q + + EK+ + ET G +++ D +I++
Sbjct: 4159 RLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 4218
Query: 1245 RIQEKVDSIDDRHRKNRETASELLMRLKDNRDL-QKFLQDCQELSLWINEKMLTAQDMSY 1303
+Q+K+D + E +L D +L +KF C +SL + K QD
Sbjct: 4219 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFW--CDHMSLIVTIK--DTQDFIR 4274
Query: 1304 D-EARNLHSKWLKHQAFMAELASNK-----EWLDKIEKEGMQLISEKPETEA-VVKEKLT 1356
D E + +K Q AE + E LD + G +LI+ E + +VK+ +
Sbjct: 4275 DLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSID 4334
Query: 1357 GLHKMWEVLESTTQTKAQRLFDANKAEL-FTQSCADLDKWLHGLESQIQS-DDYGKDLTS 1414
L+ W+ L + + +L +A +A + + + W+ ++ S G DL +
Sbjct: 4335 ELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLET 4394
Query: 1415 VNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELL--- 1471
V +++ + +++ ++ E+E L QA+ L + K T+E D TVQ MEL
Sbjct: 4395 VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK--KVTEESDKH--TVQDPLMELKLIW 4450
Query: 1472 ----EPLNERKHNLL-ASKEIHQFNRDVEDEILWVGERMPLATSTDH-GHNLQTVQLLIK 1525
E + R+H L A + QF +++ + W+ L + G + + +++ +
Sbjct: 4451 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4510
Query: 1526 KNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRH 1585
K+ LQ ++ HQ ++ + + +++ S+ A ++ +L L Q W ++E+TE+R
Sbjct: 4511 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4570
Query: 1586 RRLEEAHR-AQQYYFDAAEAEAWMSEQELYMMSEEKAKD-EQSAVSMLKKHQILEQAVED 1643
++L+ A R A+ ++ + + + W+++ E ++++ + ++A L H + A E
Sbjct: 4571 QQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4630
Query: 1644 YAETVHQLSKTSRALVADSHPESE-RISMRQSKVDKLYAGLKDLAEERRGKLDERHRL-F 1701
ET L + + ++A +E I + + + + ++ ER+ KL+E L
Sbjct: 4631 KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4690
Query: 1702 QLNREVDDLEQWIAEREV---VAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVD-- 1756
+ + + D W+ + E VA L D V + + FA + + ++ ++
Sbjct: 4691 EFHNSLQDFINWLTQAEQTLNVASRPSLILD--TVLFQIDEHKVFANEVNSHREQIIELD 4748
Query: 1757 -TVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA- 1814
T HL S D I + W +++ + R + L + + K +H+A
Sbjct: 4749 KTGTHLK---YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAW 4805
Query: 1815 KEIFGRIQDKHKKLPEEL--GRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL-- 1870
++ +++ K L EL D + ++T H F+ + A + L
Sbjct: 4806 SKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4865
Query: 1871 QAAYAGD--KADDIQKRENEVLEAWKSLLDACESRRVRLVDT-GDKFRFFSMVRDLMLWM 1927
+ + A D K DD+ +E+ + W ++ R+ +L + +F ++ L+ W+
Sbjct: 4866 KTSLADDNLKLDDML---SELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWL 4922
Query: 1928 EDVIRQI-EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASE 1986
V Q+ E Q D+ V L++NH+ + E+ R S + L+ S
Sbjct: 4923 YRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS 4982
Query: 1987 EIKEKLLQLTEKRKEMIDKWEDRWEWL---------RLILEVHQFSRDASVAEA---WLL 2034
+K ++ +L+ RWE + RL + Q SV A WL
Sbjct: 4983 WVKVQMQELS-----------TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLA 5031
Query: 2035 GQEPYLSSREI-GQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTL 2082
E L + D + LI +H+ F K +E+ + L + TT+
Sbjct: 5032 EAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL---EEKRAELNKATTM 5077
Score = 214 bits (546), Expect = 6e-55
Identities = 360/1876 (19%), Positives = 770/1876 (41%), Gaps = 157/1876 (8%)
Query: 288 KRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVG--------VQQ 339
K+ K+LD A E+ +E + +++ I+L + G + Q
Sbjct: 3352 KQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQ 3411
Query: 340 QLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERL 399
QL F ++ E P +G + + + Q +++ + + D+N W+ L
Sbjct: 3412 QLNMFKVFQKEEIEPL---QGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3468
Query: 400 EKAEHERELALRNELIR----QEKLEQLARRFDRKAAMRETWLSENQRLV-SQDNFGFDL 454
K +R L+ L+ Q+ LE L +W+ + + LV +Q +
Sbjct: 3469 NKKVAQRAAQLQEALLHCGRFQDALESLL-----------SWMVDTEELVANQKPPSAEF 3517
Query: 455 PAVEAATKKHEAIETDIAAYEERVQAVVAVARELE-----AENYHDIKRITARKDNVIRL 509
V+A ++ + ++ ++R V + RE E AE +K I + +
Sbjct: 3518 KVVKAQIQEQKLLQ---RLLDDRKSTVEVIKREGEKIATTAEPADKVK-ILKQLSLLDSR 3573
Query: 510 WEYLLELLRARRQRLE-MNLGLQKIFQEMLYIMDWMDEM-KVLVLSQDYGKHLLGVEDLL 567
WE LL R ++LE +++ Q+ + + + +W+ + K LV + G +E+ +
Sbjct: 3574 WEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQI 3633
Query: 568 QKHTLVEADIGIQAERVRGVNASAQ--KFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ 625
+H +E DI + + + Q K + E D +++ ++ + Y E+ +
Sbjct: 3634 AQHKALEDDIINHNKHLHQAVSIGQSLKVLSSRE-----DKDMVQSKLDFSQVWYIEIQE 3688
Query: 626 LAAERRARLEESRRLWKFFWE-MAEEEGWIRE---KEKILSSDDYGKDLTSVMRLLSKHR 681
+ R L+++ K F E E W+ E K LS DY + + + S+ R
Sbjct: 3689 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE--GLWKQQSELR 3746
Query: 682 AFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK--IRERIIYIREQWANLEQLSAIRKKR 739
++++ R + +QA+ G +++ ++ G E I++++ I+ ++ ++ +LS K
Sbjct: 3747 VLQEDILLRKQNVDQALLNGLELL-KQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3805
Query: 740 LEEA-SLLHQFQADADDIDAWM--LDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANY 796
LE+A L + + +++ W+ +++ + + V E ++Q+ ++ K++ +E N
Sbjct: 3806 LEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRP-KELKKEAKNN 3864
Query: 797 RPTLDTLHEQASAL----PQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALY 852
+ LD+L+E +SAL P E + ++ ERY+ V++ + + + +
Sbjct: 3865 KALLDSLNEVSSALLELVPWRAREG--LEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3922
Query: 853 KMFSEADACEL-WIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQI 911
+ F +A EL WI E E+ L + L D+ + Q + + + I
Sbjct: 3923 QQFDQAADAELSWITETEKKLMS------LGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3976
Query: 912 ARQLMHSGHP-----SEKE---IKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLE 963
L+ SGH SE+E +K + DK+ + ++ + L A S+ N E
Sbjct: 3977 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 4036
Query: 964 C-NETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL 1022
E W+ E +I + + Q + + + + + + K +L
Sbjct: 4037 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 4096
Query: 1023 ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEA-SKLQQFLRDLDDFQSWLSRT 1081
P + +I + ++ ++K +K R +L EA S+ QF +D L R
Sbjct: 4097 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4156
Query: 1082 QTAIASEDMPNTLTEAEKL---LTQHENIKNEIDNYEEDYQKMRDMGE--MVTQGQTDAQ 1136
+ P+ E EK+ +++++N+ +++ + Y+ ++ GE + G TD
Sbjct: 4157 VERL--RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4214
Query: 1137 Y--MFLRQRLQALDTGWNELHKMWENRQ-NLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA 1193
++ +L + W +H + E R+ LL ++F D + + + +
Sbjct: 4215 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIR 4274
Query: 1194 HTEMPTTLEGAEAAIKKQ-----EDFMTTMDANEEKINAVVETGRRLVSD-GNINSDRIQ 1247
E P G + ++ KQ E +D +E+++ V+ G L++ G + ++
Sbjct: 4275 DLEDP----GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4330
Query: 1248 EKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQD-CQELSLWIN---EKMLTAQDMSY 1303
+ +D ++ + + + +L++ QD Q + W++ K+ + +
Sbjct: 4331 KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT 4390
Query: 1304 DEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPE--TEAVVKEKLTGLHKM 1361
D + + + + F +E + ++++ + L+ + E + V++ L L +
Sbjct: 4391 D-LETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4449
Query: 1362 WEVLESTTQTKAQRLFDANKA-ELFTQSCADLDKWLHGLESQI-QSDDYGKDLTSVNILL 1419
W+ LE + +L A A F + +L WL E + + G D ++ I L
Sbjct: 4450 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIEL 4509
Query: 1420 KKQQMLENQMEVRKKEIEELQSQAQAL--SQEGKSTDEVDSKRLTVQTKFMELLEPLNER 1477
K +L+N + + +E + L S G+ + +K + ++ +LE +R
Sbjct: 4510 AKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQR 4569
Query: 1478 KHNL-LASKEIHQFNRDVEDEILWVGE-RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQ 1535
K L A ++ F+ ++ED W+ + L S G +T + + + + +
Sbjct: 4570 KQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFE 4629
Query: 1536 GHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA-HRA 1594
+ + ++ Q ++ + I Q + +LK+ W + + +R +LEEA + A
Sbjct: 4630 AKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLA 4689
Query: 1595 QQYYFDAAEAEAWMSEQELYM-MSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSK 1653
+++ + W+++ E + ++ + + + + +H++ V + E + +L K
Sbjct: 4690 MEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDK 4749
Query: 1654 TSRALVADSHPE-----SERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVD 1708
T L S + + QS+ +K+ ++ L E R D R R Q +
Sbjct: 4750 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKV---VQRLVERGRSLDDARKRAKQFHEAWS 4806
Query: 1709 DLEQWIAEREVVAGSH-ELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELIN 1767
L +W+ E E S E+ D + + + +EF + G DT N L
Sbjct: 4807 KLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLG-AKHSVYDTTNRTGRSL-- 4863
Query: 1768 SGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKK 1827
+ ++A+ L++ ++L + DT I S E +A G+ D +
Sbjct: 4864 ---KEKTSLADDNLKLDDMLSELRDKWDT---ICGKSVERQNKLEEALLFSGQFTDALQA 4917
Query: 1828 LPEELGR-------------DQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAY 1874
L + L R D + V L H F+ ++ + V+ L+ A L
Sbjct: 4918 LIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG- 4976
Query: 1875 AGDKADDIQKRENEVLEAWKSLLDACESRRVRL-VDTGDKFRFFSMVRDLMLWMEDVIRQ 1933
+ D + ++ + E+ W+++ S++ RL F S+V L+ W+ + +
Sbjct: 4977 SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQT 5036
Query: 1934 IEAQ-EKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKL 1992
+ P D ++ L++ H+ +++ + +G ++LA H S +
Sbjct: 5037 LRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHW 5096
Query: 1993 LQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAE---AWLLGQEPYLSSRE---IG 2046
+ + R E + W + + RL + + E AWL E L+ ++ I
Sbjct: 5097 ITIIRARFEEVLAWAKQHQ-QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 5155
Query: 2047 QSVDEVEKLIKRHEAF 2062
Q ++EV+ LI H+ F
Sbjct: 5156 QEIEEVKALIAEHQTF 5171
Score = 209 bits (533), Expect = 2e-53
Identities = 320/1645 (19%), Positives = 687/1645 (41%), Gaps = 105/1645 (6%)
Query: 387 KLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSE-NQRLV 445
K +S ++ WE L R L E + +A++F WL+ +RLV
Sbjct: 3565 KQLSLLDSRWEALLNKAETRNRQL-------EGISVVAQQFHETLEPLNEWLTTIEKRLV 3617
Query: 446 SQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDN 505
+ + G +E +H+A+E DI + + + V++ + L+ + + K + K +
Sbjct: 3618 NCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLD 3677
Query: 506 VIRLWEY-LLELLRARRQRLEMNLGLQKIF-QEMLYIMDWMDEM--KVLVLS-QDYGKHL 560
++W + E +R + L+ L KIF ++ + +M+W++E+ K+ LS QDY
Sbjct: 3678 FSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE- 3736
Query: 561 LGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCY 620
G+ + +++ DI ++ + V + + G + +I+D++ ++ Y
Sbjct: 3737 -GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTG---DEVLIIQDKLEAIKARY 3792
Query: 621 QELCQLAAERRARLEESRRLWKFFWEMAEEE-GWIREKE-KILSSDDYGKDLTSVMRLLS 678
+++ +L+ + LE++ +L + EE W+ + E ++LS + +
Sbjct: 3793 KDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQM 3852
Query: 679 KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 738
+ + + E + + ++ + + + E+++ + L + +K
Sbjct: 3853 RPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKV 3912
Query: 739 RLEEASLL--HQFQADADDIDAWMLDI-LKIVSSSDVGHDEYSTQSLVKKHKDVAEEIAN 795
+A++L QF AD +W+ + K++S D+ ++ T + ++ K EI
Sbjct: 3913 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3972
Query: 796 YRPTLDTL----HEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLAL 851
++ +D L H+ +A +E +S ++ +L + + Y + ++ R L+ +L
Sbjct: 3973 HKDIIDDLVKSGHKIMTACSEEEKQS--MKKKLDKVLKNYDTICQINSERYLQLERAQSL 4030
Query: 852 YKMFSEA-DACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNNQASRVAVVN 909
F E + W+ E + ++ + P + E L Q L + + +N
Sbjct: 4031 VNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMN 4090
Query: 910 QIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALS-IQNYHLECNETK 968
+ QL+ I+ + +T +SQ +E V ++ AL A+S +H + ++
Sbjct: 4091 KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 4150
Query: 969 SWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL-----E 1023
+ + + + ++ + + + D+ ++ L++ E++
Sbjct: 4151 ESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGG 4210
Query: 1024 SEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQ 1082
++ A+A+ +L ++ +WE + T ++ REA L + +L ++F D + TQ
Sbjct: 4211 TDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQ 4270
Query: 1083 TAIASEDMPNTLTEAEKLLTQ-HENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1141
I + P K + E I+ EID +E+ + ++G + + ++
Sbjct: 4271 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4330
Query: 1142 QRLQALDTGWNELHKMWENRQNLLSQS-HAYQQFLRDTKQAEAFLNNQEYVLAH-TEMPT 1199
+ + L++ W+ L+K W++R + L ++ A Q+ + +++ LA + + T
Sbjct: 4331 KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT 4390
Query: 1200 TLEGAEAAIKKQEDFMT---TMDANEEKINAVVETGRRLV---SDGNINSDRIQEKV--- 1250
LE + I++ + F + E++N E + V SD + D + E
Sbjct: 4391 DLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIW 4450
Query: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWI--NEKMLTAQDMSYDEARN 1308
DS+++R + L+ L +F EL W+ E +L+ Q + +
Sbjct: 4451 DSLEERIINRQHKLEGALLA------LGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKA 4504
Query: 1309 LHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAV-VKEKLTGLHKMWE-VLE 1366
+ + KH ++ +++ ++ + K G LI EA ++ KL L++ W+ VLE
Sbjct: 4505 IEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLE 4564
Query: 1367 STTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLE 1426
T Q K Q +A+ F DL +WL E + + K L + K+Q +
Sbjct: 4565 KTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLA---SKPLGGLPETAKEQLNVH 4621
Query: 1427 NQMEVRKKEIEE-----LQSQAQALSQEGKSTD-EVDSKRLTVQTKFMELLEPLNERKHN 1480
++ + EE +Q Q L++ KS + +D ++ K+ + LNERK
Sbjct: 4622 MEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTK 4681
Query: 1481 LLASKEI-HQFNRDVEDEILWVGE-RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQ 1538
L + + +F+ ++D I W+ + L ++ L TV I +++ E+ H+
Sbjct: 4682 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4741
Query: 1539 PRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAH-RAQQY 1597
+I ++ + ++ S I+ L ++ W +++ +R R L++A RA+Q+
Sbjct: 4742 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4801
Query: 1598 YFDAAEAEAWMSEQELYMMSE-EKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSR 1656
+ ++ W+ E E + SE E A D + L +H+ ++++ ++T R
Sbjct: 4802 HEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGR 4861
Query: 1657 ALVADSHPESERISMRQSKVDKLYAGLKD-------LAEERRGKLDERHRLF--QLNREV 1707
+L E ++ K+D + + L+D + ER+ KL+E LF Q +
Sbjct: 4862 SL-----KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEA-LLFSGQFTDAL 4915
Query: 1708 DDLEQWIAERE-VVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELI 1766
L W+ E +A + D + V L + + F ++ G V + A ELI
Sbjct: 4916 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALKRSARELI 4974
Query: 1767 NSGHSDAATIAEWKDGLNEAWADLLEL-IDTRTQILAA---SYELHKFYHDAKEIFGRIQ 1822
D++ + L+ W + L I +T++ AA + E H H E +
Sbjct: 4975 EGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAE 5034
Query: 1823 DK---HKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKA 1879
H LP+ D++ + TL H F ++ ++ + + A D
Sbjct: 5035 QTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSI 5090
Query: 1880 DDIQKRENEVLEAWKSLLDACESRRVRLVDT----GDKFRFFSMVRDLMLWMEDVIRQIE 1935
I+ + ++ +L + + RL K + + W E + +
Sbjct: 5091 TTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKD 5150
Query: 1936 AQEKPRDVSSVELLMNNHQGIKAEI 1960
+ P+++ V+ L+ HQ E+
Sbjct: 5151 KEVIPQEIEEVKALIAEHQTFMEEM 5175
Score = 162 bits (409), Expect = 5e-39
Identities = 251/1319 (19%), Positives = 543/1319 (41%), Gaps = 103/1319 (7%)
Query: 305 EKYESLASDLLEWIEQT---IIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGN 361
++++ A L WI +T ++ L + + Q Q+Q T + K
Sbjct: 3923 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR------HKDI 3976
Query: 362 LEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLE 421
++ L+ + M A +++ + KL + K ++ + + ER L L E+ +
Sbjct: 3977 IDDLVKSGHKIMTACSEEEKQSMKKKL-DKVLKNYDTICQINSERYLQL-------ERAQ 4028
Query: 422 QLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAAT-----KKHEAIETDIAAYEE 476
L +F WL+E Q ++SQ PA+E T ++H + IA ++
Sbjct: 4029 SLVNQFWETYEELWPWLTETQSIISQ----LPAPALEYETLRQQQEEHRQLRELIAEHKP 4084
Query: 477 RVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQE 536
+ + +L + + I + L+ + E ++ R L+ + F +
Sbjct: 4085 HIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 4144
Query: 537 ML-YIMDWMDEM-KVLVLSQDYGKHLLGVEDLLQKHTLVEADIG-----IQAERVRGVNA 589
+ I++ ++ + + L + +++ + ++ V D+ + + RG
Sbjct: 4145 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4204
Query: 590 SAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFW---- 645
A+ TD K + ++D++ M F ++ + L ER A+L + L + FW
Sbjct: 4205 IARSGGTD----KDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHM 4260
Query: 646 ----EMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEG 701
+ + + +IR+ E D G D + V + +E+ G + I G
Sbjct: 4261 SLIVTIKDTQDFIRDLE------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLG 4314
Query: 702 EDMIAEEHFGSEKI-RERIIYIREQWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAW 759
++IA + I ++ I + W +L + R +LEEA Q+Q + W
Sbjct: 4315 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4374
Query: 760 MLDIL--KIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAES 817
+ DI K+ S S +G D + + +++ K E + ++ L+ QA L ++ E
Sbjct: 4375 V-DIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4433
Query: 818 PD---VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEA-DACELWIDEKEQWLN 873
D V+ L ++ + + E R+ L+ L F A D W+ E L+
Sbjct: 4434 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS 4493
Query: 874 NMQI----PEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE-KEIKA 928
+ P+ +E +E+ +H L+ ++ S V VN+ L+ S E ++
Sbjct: 4494 EQKPVGGDPKAIE-IELAKHHV--LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4550
Query: 929 QQDKLNTRWSQFRELVDRKKDALLSAL-SIQNYHLECNETKSWIREKTKVIESTQDLGND 987
+ + LN RW E +++K L AL + +H E + + W+ + + + +++ LG
Sbjct: 4551 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-- 4608
Query: 988 LAGVMALQRKLTGMERDL-VAIEAK---LSDLQKEAEKLESEHPDQAQAILSR-LAEISD 1042
G+ ++ + ++ A EAK L ++ +++ + P A+ + + + + +
Sbjct: 4609 --GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE 4666
Query: 1043 VWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKL- 1100
WE ++T L R+ L EA L +F L DF +WL++ + + P+ + +
Sbjct: 4667 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ 4726
Query: 1101 LTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNEL-HKMWE 1159
+ +H+ NE++++ E ++ G + + ++ L ++ + W ++ ++ E
Sbjct: 4727 IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4786
Query: 1160 NRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVL-AHTEMPTTLEGAEAAIKKQEDFMTTM 1218
++L +QF + +L E L + E+ + + + + ++F ++
Sbjct: 4787 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4846
Query: 1219 DANEEKINAVVETGRRL-----VSDGNINSD----RIQEKVDSIDDRHRKNRETASELLM 1269
A + TGR L ++D N+ D +++K D+I + + + E L+
Sbjct: 4847 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4906
Query: 1270 RLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEW 1329
D + L D L+ E L + + + + H+AF EL
Sbjct: 4907 FSGQFTDALQALIDW----LYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSS 4962
Query: 1330 LDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA-NKAELFTQS 1388
+ +++ +LI + + VK ++ L WE + + + +K RL A +AE F
Sbjct: 4963 VQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSV 5022
Query: 1389 CADLDKWLHGLESQIQSDDY-GKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALS 1447
L +WL E ++ D ++ L+ + + ++E ++ E+ + + +
Sbjct: 5023 VHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 5082
Query: 1448 Q--EGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEIL-WVGER 1504
S + ++ +F E+L + + L ++ +++ + +L W+
Sbjct: 5083 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 5142
Query: 1505 MPLATSTDHG---HNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSA 1560
T D ++ V+ LI ++QT +E+ QP +D + + + D SSL +
Sbjct: 5143 ETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQS 5201
Score = 149 bits (375), Expect = 4e-35
Identities = 333/1806 (18%), Positives = 719/1806 (39%), Gaps = 200/1806 (11%)
Query: 277 FSKMKALAVEGKRIGKVLDNAIETEKMI-----EKYESLASDLLEWIEQTIIILNNRKFA 331
FSK K + E + L A++T ++ +K + LE +T+ N F+
Sbjct: 1649 FSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS 1708
Query: 332 NSLVGVQQQLQAFNTYRTV--------EKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMP 383
SL +QLQ T V E+ ++ EK L T +Q+ +M
Sbjct: 1709 ESL----KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI 1764
Query: 384 REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR 443
+G + L+K + ++E EL Q+ ++ A+ E +L EN
Sbjct: 1765 GDGTV---------ELKKYQSKQE-----EL--QKDMQGSAQALAEVVKNTENFLKENGE 1808
Query: 444 LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 503
+SQ++ + A K E + ++ + VV A + E E +K++ K
Sbjct: 1809 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESK 1868
Query: 504 DNVIRLWEYLLELLR-------ARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 556
+ L ++L + + +Q +E N G + + DE+ +L D
Sbjct: 1869 TKIENLLDWLSNVDKDSERAGTKHKQVIEQN-GTHFQEGDGKSAIGEEDEVNGNLLETDV 1927
Query: 557 -GKHLLGVEDLLQKHTLVEAD---IGIQAERVRGVNASAQ-KFATDGEGYKPCDPQVIRD 611
G+ E+L Q++ V+A I Q + V SAQ G+ P + + ++
Sbjct: 1928 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1987
Query: 612 RVAHMEFCYQELCQLAAERRARLEES--RRLWKFFWEMAEEEGWIREKEKILSSDDYG-K 668
+ ++ Y E +E++ +L S L KF + E E W+++ E+ L + + G
Sbjct: 1988 NMKELKVHY-ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 2046
Query: 669 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK-------------I 715
D+ +M L + ++F +++ G G ++ S++ +
Sbjct: 2047 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 2106
Query: 716 RERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADAD-----DIDAWMLDILKIVSSS 770
+ ++ + +++ +L + L++ +Q DA + A K + S
Sbjct: 2107 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SE 2165
Query: 771 DVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAE----SPDVRGRLSG 826
+ D + Q +++ K + +I++ + ++ L + A L D++ L
Sbjct: 2166 PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDD 2225
Query: 827 IEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNM--------QIP 878
I RY+++++ R + LQ TL + S D +DE W+ N+ Q+P
Sbjct: 2226 IVGRYEDLSKSVNERNEKLQITLT--RSLSVQDG----LDEMLDWMGNVESSLKEQGQVP 2279
Query: 879 EKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWS 938
L+ I + LE ++ + S + +N+ ++ M + PS + Q K+ +
Sbjct: 2280 LNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPS--TASSLQAKMKDLSA 2337
Query: 939 QFRELVDRKKDALLS----ALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMAL 994
+F E + K+ L ++ + + ++++ KT+ + G D+ +
Sbjct: 2338 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2397
Query: 995 QRKLTGMERDLVAIEAKLSDLQKEAEKLESEH-PDQAQAILSRLAEISDVWEEMKTTLK- 1052
++ T + + + L L +++ S P +L + +S ++EM+ T+K
Sbjct: 2398 MQESTS---EFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2454
Query: 1053 NREASLGEASKLQQFLRDLDDFQSWLSRT-------QTAIASEDMPNTLTEAEKLLTQHE 1105
+EA +L F + +SW+ T Q + +ED+ +L + +KL +
Sbjct: 2455 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWS 2514
Query: 1106 NIKNEIDNYEEDYQKMRDMG----EMVTQGQTDAQYMFLRQRLQALDTG---WNELHKMW 1158
EI QK+ + G +++ T A+ + + A+ G + W
Sbjct: 2515 LKTPEI-------QKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2567
Query: 1159 EN------RQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVL-------------------- 1192
N ++++ SH Y+ K A LN + L
Sbjct: 2568 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT 2627
Query: 1193 ----AHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDG--NINSDRI 1246
T PT E + +++ + F + N K+ + + L+ + + R
Sbjct: 2628 ATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW 2687
Query: 1247 QEKVDSIDDRHRKNRETASELLMRLKD-NRDLQKFLQDCQELSLWINEKMLTAQ---DMS 1302
++ + ID + ++ + + +L++ + +L +F +L W+ EK L +S
Sbjct: 2688 KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLS 2747
Query: 1303 YDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLIS---EKPETEAVVKEKLTGLH 1359
D L+++ + Q + E A+ K +++ G ++S E P +VKE+L +
Sbjct: 2748 ID-PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2806
Query: 1360 KMWEVLESTTQTKAQRLFDA-NKAELFTQSCADLDKWLHGLESQIQSD-DYGKDLTSVNI 1417
+ W+ L + + A K+ + L L L++++ S ++N
Sbjct: 2807 QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ 2866
Query: 1418 LLKKQQMLENQMEVRKKEIEELQSQAQ---ALSQEGKSTDEVDSKRLTVQTKFMELLEPL 1474
L+ Q ++ +++ KK+I+ Q+ + AL +E E+ + + F ++ +
Sbjct: 2867 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKA 2926
Query: 1475 -NERKHNLLASKEIHQFNRDVEDEILWVG-ERMPLATSTDHGHNLQTVQLLIKKNQTLQK 1532
N +H A HQF + D W+ ++ S L ++ LIK ++ K
Sbjct: 2927 ENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2986
Query: 1533 EIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA- 1591
+ + +N++ + A++ +L +K W ++ ++R +L+E+
Sbjct: 2987 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 3046
Query: 1592 HRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQL 1651
+A +Y W+ + + + + D + + K + L++ ++ + V L
Sbjct: 3047 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELL 3106
Query: 1652 SKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREV--DD 1709
+ T+ +L++ + E ++ + + + + ++ L+ + F+ +EV +
Sbjct: 3107 NNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 3166
Query: 1710 LEQWIAEREVVAGSHELG-QDY--EHVTMLQERFREFARDTGNIGQERVDTVNHLADELI 1766
Q +E + LG Q Y +++TMLQ + + + +VD LA +L+
Sbjct: 3167 KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSL-----QALKHQVDLAKRLAQDLV 3221
Query: 1767 -----NSGHSD----AATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEI 1817
+ G SD TIA+ L++ + ++T+ Q + F + +E+
Sbjct: 3222 VEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQ------GIGHFQNTIREM 3275
Query: 1818 FGRIQDKHKKLPE--ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYA 1875
F + + +L +GRD T++ + F ++AL + + A
Sbjct: 3276 FSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA--T 3333
Query: 1876 GDKADDIQ--KRENEVL-EAWKSLLDACESRRVRLVDTGDKF-RFFSMVRDLMLWMEDVI 1931
+ + D+ KR+ E L + LLD ++R ++ T + F+S +++ + ++
Sbjct: 3334 EETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE 3393
Query: 1932 RQIEAQ 1937
E+Q
Sbjct: 3394 EHEESQ 3399
Score = 137 bits (345), Expect = 1e-31
Identities = 280/1593 (17%), Positives = 637/1593 (39%), Gaps = 158/1593 (9%)
Query: 158 QIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNAL------ 211
Q+ I ++ + + + + AL C K G V + N+ D ++ ++
Sbjct: 3680 QVWYIEIQEKSHSRSELLQQAL---CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3736
Query: 212 -IHKHRPDLIDFDK---LKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSII 267
+ K + +L + L+K N L N L +Q G L+ + +
Sbjct: 3737 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEA--------- 3787
Query: 268 TYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNN 327
+ Y +K+ + K L+ A++ + + S +L W+++ + L +
Sbjct: 3788 --IKARYKDITKLST------DVAKTLEQALQ---LARRLHSTHEELCTWLDKVEVELLS 3836
Query: 328 RKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKV-YMPREG 386
+ ++ ++ QA + ++K K N + LL ++ A + V + REG
Sbjct: 3837 --YETQVLKGEEASQAQMRPKELKKEAK-----NNKALLDSLNEVSSALLELVPWRAREG 3889
Query: 387 --KLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR- 443
K++++ N+ + + ++ + ++R ++ FD+ A +W++E ++
Sbjct: 3890 LEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ-------FDQAADAELSWITETEKK 3942
Query: 444 LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 503
L+S + + A + + +I +++ + +V ++ + K+ +K
Sbjct: 3943 LMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKK 4002
Query: 504 -DNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY-IMDWMDEMKVLVLSQDYGKHLL 561
D V++ ++ + ++ R +LE L F E + W+ E + ++ L
Sbjct: 4003 LDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSII--SQLPAPAL 4060
Query: 562 GVEDLLQK---HTLVEADIGIQAERVRGVNASAQKFA--TDGEGYKPCDPQVIRDRVAHM 616
E L Q+ H + I + +N + + + GEG+ I+++
Sbjct: 4061 EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS------IQEKYVAA 4114
Query: 617 EFCYQELCQLAAERRARLEESRRLWKFFWEMAEE--EGWIREKEKILSSDDYGKDLTSVM 674
+ Y ++ + +R L+E+ F + ++ E R E++ ++ +
Sbjct: 4115 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 4174
Query: 675 RLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIA-----EEHFGSEKIRERIIYIREQWANL 729
+S+++ +M +E + GE+MIA ++ ++ +++++ + W N+
Sbjct: 4175 EQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI 4234
Query: 730 EQLSAIRK-KRLEEASLLHQFQADADDIDAWMLDILKIVSS-SDVGHDEYSTQSLVKKHK 787
L R+ K L+ L +F D + + D + D G D + + +
Sbjct: 4235 HTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4294
Query: 788 DVAEEIANYRPTLDTLHEQASALPQEHAE--SPDVRGRLSGIEERYKEVAELTRLRKQAL 845
+ EEI + LD + S L E P V+ + + + + + + R L
Sbjct: 4295 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4354
Query: 846 QDTLALYKMFSEA-DACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASR 904
++ + + + A W+D L +M DLE ++ + E L+ Q
Sbjct: 4355 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT--DLETVKQQIEELK-----QFKS 4407
Query: 905 VAVVNQIARQ-LMHSGHPSEKEIKAQQDK---------LNTRWSQFRELVDRKKDALLSA 954
A QI + L H K++ + DK L W E + ++ L A
Sbjct: 4408 EAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4467
Query: 955 L-SIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLS 1013
L ++ + +E +W+ ++ + +G D + K ++ D++A ++ +
Sbjct: 4468 LLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVE 4527
Query: 1014 DLQKEAEKL-ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASL-GEASKLQQFLRDL 1071
+ K L ES ++A + ++L ++ W+ + + R+ L G + + F ++
Sbjct: 4528 AVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEI 4587
Query: 1072 DDFQSWLSRTQT-AIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV-- 1128
+D Q WL+ T+ +AS+ + A++ L H + + EE Y+ + G+ +
Sbjct: 4588 EDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLA 4647
Query: 1129 -----TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSH-AYQQFLRDTKQAE 1182
+ D L+++ ++++T NE E NL + H + Q F+ QAE
Sbjct: 4648 RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4707
Query: 1183 AFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRL-VSDGNI 1241
LN + L+ I + + F ++++ E+I + +TG L
Sbjct: 4708 QTLN------VASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQ 4761
Query: 1242 NSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK-FLQDCQELSLWI--NEKMLTA 1298
+ I+ + S+ R K + E L D R K F + +L W+ +EK L +
Sbjct: 4762 DVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDS 4821
Query: 1299 QDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVK--EKLT 1356
+ ++ + ++ +H+ F L + D + G L + + +K + L+
Sbjct: 4822 ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLS 4881
Query: 1357 GLHKMWEVLESTTQTKAQRLFDANK-AELFTQSCADLDKWLHGLESQIQSDD--YGKDLT 1413
L W+ + + + +L +A + FT + L WL+ +E Q+ D +G D+
Sbjct: 4882 ELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DID 4940
Query: 1414 SVNILLKKQQMLENQMEVRKKEIEELQSQAQAL---SQEGKSTDEVDSKRLTVQTKFMEL 1470
V L+ + + ++ R ++ L+ A+ L S++ S +V + L+ + + +
Sbjct: 4941 LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCA 5000
Query: 1471 LEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHG---HNLQTVQLLIKKN 1527
L ++++ A ++ +F+ V + W+ E T HG + ++ LI ++
Sbjct: 5001 LS-ISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQ--TLRFHGVLPDDEDALRTLIDQH 5057
Query: 1528 QTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRR 1587
+ K+++ + ++ ++ S I+ + ++ + ++ ++ +R
Sbjct: 5058 KEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQR 5117
Query: 1588 LEEAHRAQQYYFDAAEAE-AWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAE 1646
L A + EA AW+ E + ++K +++ Q +E+
Sbjct: 5118 LASALAGLIAKQELLEALLAWLQWAETTLTDKDK--------------EVIPQEIEEV-- 5161
Query: 1647 TVHQLSKTSRALVADSHPESERISMRQSKVDKL 1679
+AL+A+ E ++ +Q VDK+
Sbjct: 5162 ---------KALIAEHQTFMEEMTRKQPDVDKV 5185
Score = 130 bits (326), Expect = 2e-29
Identities = 345/1826 (18%), Positives = 720/1826 (39%), Gaps = 221/1826 (12%)
Query: 359 KGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQE 418
K EVLL S + A N K + DI +E L K+ +ER L+ L R
Sbjct: 2199 KKTAEVLLDARGSLLPAKNDIQ------KTLDDIVGRYEDLSKSVNERNEKLQITLTRSL 2252
Query: 419 KLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERV 478
++ D M + + L Q + A++ K+ +E DIA + +
Sbjct: 2253 SVQ------DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSI 2306
Query: 479 QAV------------VAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEM 526
A+ + A L+A+ +K ++AR + L + + ++E+
Sbjct: 2307 NAMNEKVKKFMETTDPSTASSLQAK----MKDLSARFSEASHKHKETLAKMEELKTKVEL 2362
Query: 527 NLGLQKIFQEMLYIMDWMDEMKVLVLSQDY--GKHLLGVEDLLQKHTLVEADIGIQAERV 584
L + Q L E K L++ GK + + +Q+ T ++ + +
Sbjct: 2363 FENLSEKLQTFL-------ETKTQALTEVDVPGKDVTELSQYMQEST---SEFLEHKKHL 2412
Query: 585 RGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFF 644
+++ ++ ++ G P D ++ ++ ++ ++E+ E++ + + F
Sbjct: 2413 EVLHSLLKEISSHG---LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2469
Query: 645 WEMAEE-EGWIREKEKIL-------SSDDYGKDLTSVMRLLSKHRAFEDEMS--GRSG-- 692
+ + + WI+E K + ++D GK L +L K E+ SG
Sbjct: 2470 QVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGIS 2529
Query: 693 --HFEQAIKEGEDMIAEEHFGSEKIRER--IIYIREQWAN----------------LEQL 732
+ A+ IA G + E WAN E L
Sbjct: 2530 LCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDL 2589
Query: 733 SAIRKKRLEEA----SLLHQFQADADDIDAWMLDILKIVSS---SDVGHDEYSTQSLVKK 785
+ K ++ E S L + Q ++ + W+ + K + + D + ++ V++
Sbjct: 2590 GLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQ 2649
Query: 786 HKDVAEEIANYRPTLDTLHEQASALPQEHAESPDV---RGRLSGIEERYKEVAELTRLRK 842
+K E+ + L ++ + L +E+ ++P+ + L+ I+ +++E+ +LT R+
Sbjct: 2650 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2709
Query: 843 QALQDTLALYKMFSEADA-CELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEM-NN 900
Q L+++ F +A + W+ EKE ++ L L S++P M N
Sbjct: 2710 QKLEESSNNLTQFQTVEAQLKQWLVEKELMVS------VLGPL--------SIDPNMLNT 2755
Query: 901 QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFREL----------VDRKKDA 950
Q +V QI Q + P +++ A + +R + L V +K D+
Sbjct: 2756 QRQQV----QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2811
Query: 951 LLSALS-----IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDL 1005
L LS I ++ + +S +R + + DL N L+ +A+ M + L
Sbjct: 2812 LTGQLSDRCDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVSTHPDAMNQQL 2868
Query: 1006 VAIEAKLSDLQKEAEKLESEHP-----------DQAQAILSR-----LAEISDVWEEMKT 1049
+ ++Q+E ++++ + +A LSR L DV ++ +
Sbjct: 2869 ETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2928
Query: 1050 TLKNREASLGEASKLQQFLRDLDDFQSWL-SRTQTAIASEDMPNTLTEAEKLLTQHENIK 1108
+++ +++ + + QQ RD FQ+WL ++ + S + L E L+ H++
Sbjct: 2929 HVQHLQSACASSHQFQQMSRD---FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2985
Query: 1109 NEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQS 1168
+ Y+K GE + ++ L+ +L + T W+ +K + R+N L +S
Sbjct: 2986 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES 3045
Query: 1169 HAYQQFLRDTKQAEAF-------LNNQEYVLAHTEMPTTLEGAEA--AIKKQEDFMTTMD 1219
++ L+ +Q E NN E E+ L+ AE +I K + MD
Sbjct: 3046 --LEKALKYKEQVETLWPWIDKCQNNLE------EIKFCLDPAEGENSIAKLKSLQKEMD 3097
Query: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQ-------EKVDSIDDRHRKNRETASELLMRLK 1272
+ + + T L+S I+ + + +KVD + ++ + + + K
Sbjct: 3098 QHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3157
Query: 1273 DNRDLQKFLQ---DCQELSLWINEKM----LTAQDMSYDEARNLHSKWLKHQAFMAELAS 1325
+ +++ K + C + L I++ + + + ++ + + + LKHQ +A+ +
Sbjct: 3158 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3217
Query: 1326 NKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL--FDANKAE 1383
++ + +G + + ET + ++ + L + + S +TK Q + F E
Sbjct: 3218 QDLVVEASDSKGTSDVLLQVET---IAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIRE 3274
Query: 1384 LFTQSCADLDKWLHGLES-QIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ 1442
+F+Q A+ D L + ++ K ++ LKK + L + K + +
Sbjct: 3275 MFSQ-FAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM--- 3330
Query: 1443 AQALSQEGKSTDEVDSKR--LTVQTKFMELLEPLNERKHNLLAS-KEIHQFNRDVED-EI 1498
L+ E S D V KR + + +LL+ R+ + + K + +F +++ I
Sbjct: 3331 ---LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI 3387
Query: 1499 LWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQK-EIQGHQPRIDDIFERSQNIVTDSS- 1556
L + G +T+ + + QK EI+ Q + D+ Q ++ ++
Sbjct: 3388 LLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK 3447
Query: 1557 SLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEA-EAWMSEQELYM 1615
S S + + L D+ W L ++ +R +L+EA + DA E+ +WM + E +
Sbjct: 3448 STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV 3507
Query: 1616 MSEEKAKDEQSAV-SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHP-ESERISMRQ 1673
+++ E V + +++ ++L++ ++D TV + + + + P + +I +
Sbjct: 3508 ANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQL 3567
Query: 1674 SKVDKLYAGLKDLAEERRGKLDERHRLF-QLNREVDDLEQWIAEREV-VAGSHELGQDYE 1731
S +D + L + AE R +L+ + Q + ++ L +W+ E + +G
Sbjct: 3568 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3627
Query: 1732 HVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLL 1791
+ + + D N + V+ + S D + D + ++
Sbjct: 3628 KLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3687
Query: 1792 ELIDTRTQIL-AASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHT--- 1847
E +R+++L A F D E+ + + H KL + +D +T E L + +
Sbjct: 3688 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYST-EGLWKQQSELR 3746
Query: 1848 TFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRL 1907
+ DI V Q + L GD+ IQ + + +K + L
Sbjct: 3747 VLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3806
Query: 1908 VDTGD-KFRFFSMVRDLMLWMEDVIRQIEAQE----KPRDVSSVEL----LMNNHQGIKA 1958
R S +L W++ V ++ + E K + S ++ L + KA
Sbjct: 3807 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3866
Query: 1959 EIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMI-DKWEDRWEWL-RLI 2016
+D+ N E+ +LL + + E EK++ +R ++ D + E + I
Sbjct: 3867 LLDSLN-------EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3919
Query: 2017 LEVHQFSRDASVAEAWLLGQEPYLSS 2042
L QF + A +W+ E L S
Sbjct: 3920 LRSQQFDQAADAELSWITETEKKLMS 3945
Score = 104 bits (260), Expect = 9e-22
Identities = 330/1756 (18%), Positives = 665/1756 (37%), Gaps = 240/1756 (13%)
Query: 627 AAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTS-VMRLLSKHRAFED 685
AAE +L E++ + EEE I +K I + K S V A ED
Sbjct: 1361 AAEALVKLYETK--------LCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALED 1412
Query: 686 EMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASL 745
E+ ++ K ++ + + EK + + E+W N+ R + LE
Sbjct: 1413 ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLV----ERWQNVHVQIDNRLRDLEGIGK 1468
Query: 746 LHQFQADA-DDIDAWMLDI----LKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTL 800
++ D +D W+ + KI + +TQ + + K + EI + +
Sbjct: 1469 SLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ--LNQQKMLVSEIEMKQSKM 1526
Query: 801 DTLHEQAS-----------------ALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQ 843
D + A A+ +SP R R+ + + R R
Sbjct: 1527 DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYT 1586
Query: 844 ALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE--------VIQHRFESLE 895
AL + Y F+ L +EK + EK ++L+ ++ ++ +
Sbjct: 1587 ALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGK 1646
Query: 896 PEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKL-NTRWSQFRELVDRKKDALLSA 954
P + Q ++ QL + + + DK+ + ++ + V +++
Sbjct: 1647 PPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL 1706
Query: 955 LSIQNYHLECNETKSWIREKTKVI-ESTQDLGNDLAGVMALQRKLTGMERDLVAIE---- 1009
S L+ ++T ++ + K++ E Q+ L G+ L LT E L+ +
Sbjct: 1707 FSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDL---LTQTENRLIGHQEAFM 1763
Query: 1010 -----AKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEAS-- 1062
+L Q + E+L+ + AQA+ + + +E L + +L E
Sbjct: 1764 IGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLN 1823
Query: 1063 ----KLQQFLRDLDDFQSWLSRTQTAIASEDMPNT--LTEAEKLLTQHENIKNEIDNYEE 1116
K +Q + + L + T E+ + + E+ T+ EN+ + + N ++
Sbjct: 1824 EAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDK 1883
Query: 1117 DYQKMRDMG-EMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFL 1175
D ++ +++ Q T Q + + D L + + Q +Q + QQ+
Sbjct: 1884 DSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQ 1943
Query: 1176 RDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRL 1235
+ Q E ++ + V+ T+ A+ ++KQ +++ EEK
Sbjct: 1944 KVKAQHEKIISQHQAVIIATQ------SAQVLLEKQGQYLSP----EEK----------- 1982
Query: 1236 VSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDN--RDLQKFLQDCQELSLWI-- 1291
+++Q+ + + H + SE M+L + +L+KF D E W+
Sbjct: 1983 --------EKLQKNMKELKV-HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQ 2033
Query: 1292 NEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE-------- 1343
+E+ L + D+ L +K + ++F ++ S+K L I G +++
Sbjct: 2034 SEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRD 2093
Query: 1344 --KPETEAV---VKEKLTGLHKMWEVLESTTQTKAQRLFD-ANKAELFTQSCADLDKWLH 1397
K +T A V+ KL + L S L D +K + + + L L
Sbjct: 2094 GGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQ 2153
Query: 1398 GLE---SQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKST- 1453
E S+ S+ D ++ L++ + L+ Q+ ++ +E+L+ A+ L S
Sbjct: 2154 ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLL 2213
Query: 1454 ---DEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEIL-WVGE-RMPLA 1508
+++ + ++ +L + +NER L + +D DE+L W+G L
Sbjct: 2214 PAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 2273
Query: 1509 TSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLA 1568
N +Q +I KN L+++I G Q I+ + E+ + + + +A +++ ++
Sbjct: 2274 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 2333
Query: 1569 DLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSE----EKAKDE 1624
DL + + ++ ++EE + + + +E E + ++E K E
Sbjct: 2334 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 2393
Query: 1625 QSAVSMLKKHQILEQAVEDYAETVHQLSK--TSRALVADSHPESERISMRQSKVDKLYAG 1682
S + LE + + E +H L K +S L +D + + + + K +
Sbjct: 2394 LSQYMQESTSEFLEH--KKHLEVLHSLLKEISSHGLPSD----KALVLEKTNNLSKKFKE 2447
Query: 1683 LKDLAEERRGKLDE-RHRLFQLNREVDDLEQWIAER-------EVVAGSHELGQDYEHVT 1734
++D +E++ + + +L V L+ WI E + G+ +LG+ E
Sbjct: 2448 MEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTK 2507
Query: 1735 MLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDG---LN-EAWADL 1790
LQE++ + + + N LI++ + A IA K G LN E A
Sbjct: 2508 KLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGAVLNGEGTATN 2562
Query: 1791 LELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVET-------LQ 1843
E + + ++ H +++ ++DK +L +L + Q E LQ
Sbjct: 2563 TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQ 2622
Query: 1844 RMHTTFEH--------DIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLE---- 1891
+M+ T D +A+ TQV Q + A L+ +K +++ + E+LE
Sbjct: 2623 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNV--NKVQELKDKLTELLEENPD 2680
Query: 1892 -----AWKSLLDACES-----------RRVRLVDTGDKFRFFSMVR-DLMLWM-EDVIRQ 1933
WK +L +S R+ +L ++ + F V L W+ E +
Sbjct: 2681 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2740
Query: 1934 IEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASE---EIKE 1990
D + + Q + E R + G+ +L+R +KE
Sbjct: 2741 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2800
Query: 1991 KLLQLTEKRKEMIDKWEDRWEWL-RLILEVHQFSR------------DASVAEAWLLGQE 2037
+L +T+K + + DR +W+ + I++ Q+ D ++ + +
Sbjct: 2801 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2860
Query: 2038 P------YLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLE----LLE 2086
P +++++ Q + + +K IK +A E +A E + E LE +
Sbjct: 2861 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2920
Query: 2087 VRRQQEEEERKRRPPSPEPSTKVSEEAESQQQW-DTSKGEQVSQNGLPAEQGSPRMAETV 2145
Q+ E + + S + + + Q W DT K EQ + + A+ +
Sbjct: 2921 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAK---------L 2971
Query: 2146 DTSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLN 2205
D E + K+ S + S KT ++ L +TQ + A ++ LN
Sbjct: 2972 DVLESL------IKDHKDFSKTLTAQSHMYEKTIAEGEN---LLLKTQGSEKAALQLQLN 3022
Query: 2206 R-KHEWEAHNKKASSR 2220
K W+ NK+ R
Sbjct: 3023 TIKTNWDTFNKQVKER 3038
Score = 98.6 bits (244), Expect = 6e-20
Identities = 318/1721 (18%), Positives = 645/1721 (37%), Gaps = 318/1721 (18%)
Query: 514 LELLRARRQRLEMNLGLQKIFQE---MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDLL 567
L+L++ R+ L+ +L Q + +E M ++ D W+DEM+V + ++G L VE L
Sbjct: 757 LKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHL 816
Query: 568 QKHTLV-----EADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQE 622
+ H V E + ++ ++ + +A T E ++ +E Y +
Sbjct: 817 ENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAE------------KLHRLESQYAK 864
Query: 623 LCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRA 682
L + + L+ L F E W+ EKE+ + D+ + T++ R H
Sbjct: 865 LLNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAE 921
Query: 683 FEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEE 742
E+ + + + + E ++ E H I ++ QW+ + QL ++ ++E
Sbjct: 922 LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKE 981
Query: 743 ASLLHQFQADADDIDAWMLDILKIVS---SSDVGHDEYSTQSLVKKHKDVAEEIANYRPT 799
+ +F DA + ++ ++ + S D + + LV++ + EE+ Y+ T
Sbjct: 982 NTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKST 1041
Query: 800 LDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEAD 859
+ L +A + Q ++ R + T + +A+ D + + D
Sbjct: 1042 IANLMGKAKTIIQ--------------LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDD 1087
Query: 860 ACELWID-EKEQWL------NNMQIP-----------EKLEDLEVIQHRFESL------- 894
C L + + +W N +P E ++ I+ +++++
Sbjct: 1088 ECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHES 1147
Query: 895 EPEMNNQASRVAVVNQIARQLMHSGHPSEKEI--KAQQDKLNTRWSQFRE-LVDRKKDAL 951
M + S ++N+I R + S S K + Q L+ S+F + L D ++ +
Sbjct: 1148 HINMKSVVSWHYLINEIDR-IRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQV 1206
Query: 952 LSALSIQNYHLECNETKSWIREKTKVIESTQD----LGNDLAGVMALQRKL--------- 998
S I E N K + +E K E + ++ V ++ +L
Sbjct: 1207 FSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIR 1266
Query: 999 ---TGMERD----LVAIEAKLSDLQKEAEKLESE---HPDQAQAILSRLAEISDV---WE 1045
T +ERD V + L+KE E+L+ + ++ + S+ A S V
Sbjct: 1267 QIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRS 1326
Query: 1046 EMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNT-LTEAEKLLTQH 1104
E+ L+N +S ++ L L TQ A A + T L E E ++
Sbjct: 1327 ELNVVLQNMNQVYSMSS---TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK 1383
Query: 1105 ENIKN----------EIDN-------YEEDYQKMRDMGEMV--TQGQTDAQYMFLRQRLQ 1145
NI+N E+D E++ QK + + + + T + D + + +++
Sbjct: 1384 NNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD 1443
Query: 1146 ALDTGWNELHKMWENRQNLLSQSHAYQQFLRDT--------------------------K 1179
L W +H +NR L ++ RDT K
Sbjct: 1444 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSK 1503
Query: 1180 QAEAFLNNQEYVLAHTEMPTT--------LEGAEAAIKKQE----DFMTTMDANEE---- 1223
LN Q+ +++ EM + E A +K E + +D+ ++
Sbjct: 1504 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVK 1563
Query: 1224 --------------------KINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRET 1263
+ A+V + + + R++E+ S+++ +++ E
Sbjct: 1564 RRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEK 1623
Query: 1264 ASEL-------LMRLKDNRDLQKFLQDCQELSL--------WINEKMLTAQ-------DM 1301
A EL LKD K Q++S ++E + T Q D
Sbjct: 1624 AKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDK 1683
Query: 1302 SYDEARNLHSKWLK--HQAFMAELASNKEWLDKIEKEGMQLISEK--PETEAVVKEKLTG 1357
DE RN K +K +++ + + + L + + G + EK E + KEKL G
Sbjct: 1684 MTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQG 1743
Query: 1358 LHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNI 1417
+ + TQT+ RL +A + +L K+ + ++Q D G +
Sbjct: 1744 ------ICDLLTQTE-NRLIGHQEAFMIGDGTVELKKY-QSKQEELQKDMQGSAQALAEV 1795
Query: 1418 LLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFME------LL 1471
+ + L K+ E+L + +AL ++ + ++ ++L ++ + + +
Sbjct: 1796 VKNTENFL-------KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1848
Query: 1472 EPLNERKHNLLASKEIHQFNRDVEDEILWVG--ERMPLATSTDHGHNLQTVQLLIKKNQT 1529
+ E + A K++ + +E+ + W+ ++ T H + +I++N T
Sbjct: 1849 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH-------KQVIEQNGT 1901
Query: 1530 LQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLE 1589
+E G + I + E + N++ ++ L Q + + +H ++
Sbjct: 1902 HFQEGDG-KSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQ-------KVKAQHEKII 1953
Query: 1590 EAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVH 1649
H+A A+ + +Q Y+ EEK K +++ + ++ E + H
Sbjct: 1954 SQHQA--VIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTH 2011
Query: 1650 QLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDD 1709
L + AD + + +++ L AG D+ + +L R+
Sbjct: 2012 SLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDI----------NGLMTKLKRQKSF 2061
Query: 1710 LEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSG 1769
E I+ + D ++T+ R E A+ +VDT
Sbjct: 2062 SEDVISHK----------GDLRYITISGNRVLEAAKSCSKRDGGKVDT------------ 2099
Query: 1770 HSDAATIAEWKDGLNEAWADLLELIDTRTQILAAS----YELHKFYHDAK-EIFGRIQ-- 1822
+AT E + L+ A D + ++ +L + + ++ Y DA + +Q
Sbjct: 2100 ---SATHREVQRKLDHA-TDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQAC 2155
Query: 1823 --DKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAG--DK 1878
K L E + D ++ + I + V +L++ A L A
Sbjct: 2156 EATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPA 2215
Query: 1879 ADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLML-WMEDVIRQIEAQ 1937
+DIQK ++++ ++ L + R +L T + D ML WM +V ++ Q
Sbjct: 2216 KNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ 2275
Query: 1938 EKP-------RDVSSVELLMNNH-QGIKAEIDARNDSFTTCIELG------------KSL 1977
+ +D+ S +++ G ++ I+A N+ +E K L
Sbjct: 2276 GQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2335
Query: 1978 LARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILE 2018
AR AS + KE L ++ E+ K ++ +E+ E L+ LE
Sbjct: 2336 SARFSEASHKHKETLAKM-EELKTKVELFENLSEKLQTFLE 2375
Score = 53.1 bits (126), Expect = 3e-06
Identities = 52/281 (18%), Positives = 116/281 (41%), Gaps = 28/281 (9%)
Query: 293 VLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAF-NTYRTVE 351
+LD + E++ K+ DLL W+++ + L+ ++ + L V+ L+ N +R +E
Sbjct: 771 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 827
Query: 352 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 411
+ ++ + + T K+ + + + + + ++ ER H
Sbjct: 828 EFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRAT 887
Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDI 471
NELI + E+ +D W N + + ++ H + ++
Sbjct: 888 NELIWLNEKEEEEVAYD--------WSERNTNIARKKDY-------------HAELMREL 926
Query: 472 AAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQ 531
EE +++V +A +L EN+ I A + + W ++L+L + Q ++ N
Sbjct: 927 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 986
Query: 532 KIFQEMLYIMDWMDEMKVLV---LSQDYGKHLLGVEDLLQK 569
+ F + D++ +K + S D + +EDL+Q+
Sbjct: 987 EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQE 1027
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.128 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,627,590
Number of Sequences: 37866
Number of extensions: 3547662
Number of successful extensions: 24263
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 168
Number of HSP's successfully gapped in prelim test: 834
Number of HSP's that attempted gapping in prelim test: 14998
Number of HSP's gapped (non-prelim): 5048
length of query: 2364
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2245
effective length of database: 13,741,464
effective search space: 30849586680
effective search space used: 30849586680
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.