Guide to the Human Genome
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Search of human proteins with 110825963

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|110825963 poly (ADP-ribose) polymerase family, member 2
isoform 2 [Homo sapiens]
         (570 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|110825963 poly (ADP-ribose) polymerase family, member 2 isofo...  1159   0.0  
gi|110825961 poly (ADP-ribose) polymerase family, member 2 isofo...  1150   0.0  
gi|156523968 poly (ADP-ribose) polymerase family, member 1 [Homo...   386   e-107
gi|158634482 poly (ADP-ribose) polymerase family, member 3 isofo...   265   8e-71
gi|158634478 poly (ADP-ribose) polymerase family, member 3 isofo...   265   8e-71
gi|112789550 poly (ADP-ribose) polymerase family, member 4 [Homo...   103   3e-22
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    43   9e-04
gi|24432009 poly (ADP-ribose) polymerase family, member 8 [Homo ...    41   0.003
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    40   0.008
gi|94536838 poly (ADP-ribose) polymerase family, member 6 [Homo ...    39   0.013
gi|154354979 myosin X [Homo sapiens]                                   38   0.022
gi|221219020 NYD-SP11 protein [Homo sapiens]                           36   0.083
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]                    35   0.14 
gi|22035679 AT rich interactive domain 4B isoform 2 [Homo sapiens]     35   0.14 
gi|22035677 AT rich interactive domain 4B isoform 1 [Homo sapiens]     35   0.14 
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi...    35   0.19 
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap...    34   0.41 
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap...    34   0.41 
gi|30794488 kinesin family member 27 [Homo sapiens]                    34   0.41 
gi|110618244 retinoblastoma binding protein 2 isoform 1 [Homo sa...    33   0.70 
gi|110618242 retinoblastoma binding protein 2 isoform 2 [Homo sa...    33   0.70 
gi|58535453 CDK5 regulatory subunit associated protein 2 isoform...    32   1.6  
gi|15559211 RE1-silencing transcription factor [Homo sapiens]          32   1.6  
gi|239758013 PREDICTED: hypothetical protein [Homo sapiens]            32   1.6  
gi|194328777 poly (ADP-ribose) polymerase family, member 11 [Hom...    32   1.6  
gi|4505531 oxysterol binding protein [Homo sapiens]                    32   1.6  
gi|122937211 KIAA0368 protein [Homo sapiens]                           32   1.6  
gi|38524594 TCDD-inducible poly(ADP-ribose) polymerase [Homo sap...    32   2.0  
gi|42476024 THUMP domain containing 1 [Homo sapiens]                   32   2.0  
gi|58535451 CDK5 regulatory subunit associated protein 2 isoform...    31   2.7  

>gi|110825963 poly (ADP-ribose) polymerase family, member 2 isoform
           2 [Homo sapiens]
          Length = 570

 Score = 1159 bits (2998), Expect = 0.0
 Identities = 570/570 (100%), Positives = 570/570 (100%)

Query: 1   MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD 60
           MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
Sbjct: 1   MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD 60

Query: 61  RTEDKQDESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYL 120
           RTEDKQDESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYL
Sbjct: 61  RTEDKQDESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYL 120

Query: 121 IQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDREK 180
           IQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDREK
Sbjct: 121 IQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDREK 180

Query: 181 FEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAMEE 240
           FEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAMEE
Sbjct: 181 FEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAMEE 240

Query: 241 MMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDF 300
           MMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDF
Sbjct: 241 MMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDF 300

Query: 301 GLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQHYRNLHCALRPLD 360
           GLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQHYRNLHCALRPLD
Sbjct: 301 GLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQHYRNLHCALRPLD 360

Query: 361 HESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMS 420
           HESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMS
Sbjct: 361 HESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMS 420

Query: 421 NWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALG 480
           NWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALG
Sbjct: 421 NWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALG 480

Query: 481 QCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYT 540
           QCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYT
Sbjct: 481 QCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYT 540

Query: 541 LNYNEYIVYNPNQVRMRYLLKVQFNFLQLW 570
           LNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
Sbjct: 541 LNYNEYIVYNPNQVRMRYLLKVQFNFLQLW 570


>gi|110825961 poly (ADP-ribose) polymerase family, member 2 isoform
           1 [Homo sapiens]
          Length = 583

 Score = 1150 bits (2974), Expect = 0.0
 Identities = 570/583 (97%), Positives = 570/583 (97%), Gaps = 13/583 (2%)

Query: 1   MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD 60
           MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
Sbjct: 1   MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD 60

Query: 61  RTEDKQD-------------ESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN 107
           RTEDKQD             ESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
Sbjct: 61  RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN 120

Query: 108 QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF 167
           QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
Sbjct: 121 QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF 180

Query: 168 LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE 227
           LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
Sbjct: 181 LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE 240

Query: 228 LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME 287
           LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
Sbjct: 241 LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME 300

Query: 288 ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ 347
           ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
Sbjct: 301 ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ 360

Query: 348 HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL 407
           HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
Sbjct: 361 HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL 420

Query: 408 HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK 467
           HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
Sbjct: 421 HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK 480

Query: 468 NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP 527
           NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
Sbjct: 481 NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP 540

Query: 528 ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW 570
           ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
Sbjct: 541 ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW 583


>gi|156523968 poly (ADP-ribose) polymerase family, member 1 [Homo
            sapiens]
          Length = 1014

 Score =  386 bits (991), Expect = e-107
 Identities = 216/516 (41%), Positives = 323/516 (62%), Gaps = 17/516 (3%)

Query: 59   KDRTEDKQDESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKY 118
            K+   +K ++ +K L LKG A VDP+   +   AHV  +G  V+   L   ++    N Y
Sbjct: 512  KEEGINKSEKRMK-LTLKGGAAVDPDSGLE-HSAHVLEKGGKVFSATLGLVDIVKGTNSY 569

Query: 119  YLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDR 178
            Y +QLLEDD +  + ++  WGRVG +   + +    +   A E F K + +KT N W  +
Sbjct: 570  YKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSK 629

Query: 179  EKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAM 238
              F K P K+  L++DY    QDEE  KK   L      +S+L   VQ+LIK+I +V++M
Sbjct: 630  N-FTKYPKKFYPLEIDYG---QDEEAVKK---LTVNPGTKSKLPKPVQDLIKMIFDVESM 682

Query: 239  EEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPH 298
            ++ M+E + + +K PLGKL+  QI+A Y  L +++  +  G     +++  N FYT IPH
Sbjct: 683  KKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPH 742

Query: 299  DFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQ-SPEHPLDQHYRNLHCALR 357
            DFG++ PPL+     +  K+++L+ L DIE+A  L++     S + P+D +Y  L   ++
Sbjct: 743  DFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIK 802

Query: 358  PLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFR--EDLHNRMLLWH 415
             +D +S E ++I +Y+++THA TH+ Y + ++D+F++E++GE + ++  + LHNR LLWH
Sbjct: 803  VVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWH 862

Query: 416  GSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLS 475
            GSR +N+ GILS GLRIAPPEAP+TGYMFGKGIYFADM SKSANYC  S+    GL+LL 
Sbjct: 863  GSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLG 922

Query: 476  EVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILN 535
            EVALG   EL  A+  ++ L +GKHS KGLGK  P  +  ++L+G  VPLG    +G+  
Sbjct: 923  EVALGNMYELKHASHISK-LPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGV-- 979

Query: 536  PDGYTLNYNEYIVYNPNQVRMRYLLKVQFNF-LQLW 570
             +  +L YNEYIVY+  QV ++YLLK++FNF   LW
Sbjct: 980  -NDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 1014


>gi|158634482 poly (ADP-ribose) polymerase family, member 3 isoform
           b [Homo sapiens]
          Length = 533

 Score =  265 bits (677), Expect = 8e-71
 Identities = 186/536 (34%), Positives = 290/536 (54%), Gaps = 38/536 (7%)

Query: 46  ESKKMPVAGGKANKDRTEDKQDESVKALLLKGKA-PVDPECTAKVGKAHVYCEGNDVYDV 104
           E KK   AG + +  R+     E++KA+  + +   VDP C           E    Y+ 
Sbjct: 15  EKKKGRQAGREEDPFRSTA---EALKAIPAEKRIIRVDPTCPLSSNPGTQVYED---YNC 68

Query: 105 MLNQTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQ 164
            LNQTN++ NNNK+Y+IQLL+D + R F+ W  WGRVG++GQ S +     L  AK+ F+
Sbjct: 69  TLNQTNIENNNNKFYIIQLLQD-SNRFFTCWNHWGRVGEVGQ-SKINHFTRLEDAKKDFE 126

Query: 165 KKFLDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQ---- 220
           KKF +KTKNNW +R+ F   PGKY ++++      +DE +    +  + P++  ++    
Sbjct: 127 KKFREKTKNNWAERDHFVSHPGKYTLIEV----QAEDEAQEAVVKVDRGPVRTVTKRVQP 182

Query: 221 --LDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRA 278
             LD   Q+LI  I + +  +  M  M  + KK PLGKL+  QI  G+++L+ +E+ ++ 
Sbjct: 183 CSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKG 242

Query: 279 -GQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEI--AIKLVK 335
               G++L E  + FYT IPH+FG   PP I + + L  K  +L  L DIE+  A++ V 
Sbjct: 243 PTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVS 302

Query: 336 TELQSPE---HPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLF 392
            + ++ E   HPLD+ Y+ L C L+ LD  + E+KVI  YL+ T +   +    TL  ++
Sbjct: 303 EQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGS---NHRCPTLQHIW 359

Query: 393 EVEKDGEKEAFR--EDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYF 450
           +V ++GE++ F+    L NR LLWHG+ M+    IL+ GLRI P     +G   GKGIYF
Sbjct: 360 KVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPH----SGGRVGKGIYF 415

Query: 451 ADMSSKSANYCFASR--LKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHS--TKGLG 506
           A  +SKSA Y    +    + G + L EVALG+ + +   NP  +    G  S   +G  
Sbjct: 416 ASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHT 475

Query: 507 KMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKV 562
           +  P+    + L+G  V +              T + +EY++Y  +Q R+RYLL+V
Sbjct: 476 EPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEV 531


>gi|158634478 poly (ADP-ribose) polymerase family, member 3 isoform
           a [Homo sapiens]
          Length = 540

 Score =  265 bits (677), Expect = 8e-71
 Identities = 186/536 (34%), Positives = 290/536 (54%), Gaps = 38/536 (7%)

Query: 46  ESKKMPVAGGKANKDRTEDKQDESVKALLLKGKA-PVDPECTAKVGKAHVYCEGNDVYDV 104
           E KK   AG + +  R+     E++KA+  + +   VDP C           E    Y+ 
Sbjct: 22  EKKKGRQAGREEDPFRSTA---EALKAIPAEKRIIRVDPTCPLSSNPGTQVYED---YNC 75

Query: 105 MLNQTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQ 164
            LNQTN++ NNNK+Y+IQLL+D + R F+ W  WGRVG++GQ S +     L  AK+ F+
Sbjct: 76  TLNQTNIENNNNKFYIIQLLQD-SNRFFTCWNHWGRVGEVGQ-SKINHFTRLEDAKKDFE 133

Query: 165 KKFLDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQ---- 220
           KKF +KTKNNW +R+ F   PGKY ++++      +DE +    +  + P++  ++    
Sbjct: 134 KKFREKTKNNWAERDHFVSHPGKYTLIEV----QAEDEAQEAVVKVDRGPVRTVTKRVQP 189

Query: 221 --LDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRA 278
             LD   Q+LI  I + +  +  M  M  + KK PLGKL+  QI  G+++L+ +E+ ++ 
Sbjct: 190 CSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKG 249

Query: 279 -GQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEI--AIKLVK 335
               G++L E  + FYT IPH+FG   PP I + + L  K  +L  L DIE+  A++ V 
Sbjct: 250 PTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVS 309

Query: 336 TELQSPE---HPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLF 392
            + ++ E   HPLD+ Y+ L C L+ LD  + E+KVI  YL+ T +   +    TL  ++
Sbjct: 310 EQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGS---NHRCPTLQHIW 366

Query: 393 EVEKDGEKEAFR--EDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYF 450
           +V ++GE++ F+    L NR LLWHG+ M+    IL+ GLRI P     +G   GKGIYF
Sbjct: 367 KVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPH----SGGRVGKGIYF 422

Query: 451 ADMSSKSANYCFASR--LKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHS--TKGLG 506
           A  +SKSA Y    +    + G + L EVALG+ + +   NP  +    G  S   +G  
Sbjct: 423 ASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHT 482

Query: 507 KMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKV 562
           +  P+    + L+G  V +              T + +EY++Y  +Q R+RYLL+V
Sbjct: 483 EPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEV 538


>gi|112789550 poly (ADP-ribose) polymerase family, member 4 [Homo
           sapiens]
          Length = 1724

 Score =  103 bits (258), Expect = 3e-22
 Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 52/351 (14%)

Query: 219 SQLDLRVQELIKLICN--VQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCI 276
           S L   V +L+++I    +  +E M+++        P+ ++++  +      L  ++  +
Sbjct: 257 STLSQEVSDLVEMIWAEALGHLEHMLLK--------PVNRISLNDVSKAEGILLLVKAAL 308

Query: 277 RAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKT 336
           + G+    L +   EFY  IPH     T P       L++K  L + + D+   + + +T
Sbjct: 309 KNGETAEQLQKMMTEFYRLIPHK---GTMPKEVNLGLLAKKADLCQLIRDM---VNVCET 362

Query: 337 ELQSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEK 396
            L  P  P    YR L C +  ++  + EF  + + +   H   HS   + +L +F V +
Sbjct: 363 NLSKPNPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNH---HSKSPVDVLQIFRVGR 419

Query: 397 DGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYM------FGKGIYF 450
             E   F   L N   L HGS + N VGIL  GL + P      G         G GIYF
Sbjct: 420 VNETTEFLSKLGNVRPLLHGSPVQNIVGILCRGL-LLPKVVEDRGVQRTDVGNLGSGIYF 478

Query: 451 ADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAP 510
           +D  S S  Y        T LLL+ +VALG+C +L E +        G  S  G+ + A 
Sbjct: 479 SDSLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTAS 538

Query: 511 SSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLK 561
            +  F                            +E++VY  NQV+M+Y++K
Sbjct: 539 VTTDF--------------------------EDDEFVVYKTNQVKMKYIIK 563


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase [Homo sapiens]
          Length = 1327

 Score = 42.7 bits (99), Expect = 9e-04
 Identities = 47/156 (30%), Positives = 60/156 (38%), Gaps = 23/156 (14%)

Query: 408  HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK 467
            HN  +L+HGS   N   I+  G           G MFG GIYFA+ SSKS  Y +     
Sbjct: 1177 HNERMLFHGSPFIN--AIIHKGF---DERHAYIGGMFGAGIYFAENSSKSNQYVYGIG-G 1230

Query: 468  NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP 527
             TG     + +   C+             Q       LGK   S   F T+  +  P G 
Sbjct: 1231 GTGCPTHKDRSCYICHR------------QMLFCRVTLGK---SFLQFSTMKMAHAPPGH 1275

Query: 528  ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQ 563
             S  G   P    L Y EY++Y   Q    YL+  Q
Sbjct: 1276 HSVIG--RPSVNGLAYAEYVIYRGEQAYPEYLITYQ 1309


>gi|24432009 poly (ADP-ribose) polymerase family, member 8 [Homo
           sapiens]
          Length = 854

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 21/48 (43%), Positives = 28/48 (58%), Gaps = 1/48 (2%)

Query: 414 WHGSRMSNWVGILSHGLRIAP-PEAPITGYMFGKGIYFADMSSKSANY 460
           +HGS + NW  IL +GL +A      + G M+G GIY + MSS S  Y
Sbjct: 696 FHGSHIENWHSILRNGLVVASNTRLQLHGAMYGSGIYLSPMSSISFGY 743


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase 2 [Homo sapiens]
          Length = 1166

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 55/222 (24%), Positives = 84/222 (37%), Gaps = 40/222 (18%)

Query: 359  LDHESYEFKVISQYLQST----HAPTHSDYTMTLLDLFEVEKDGEKEAFREDLH------ 408
            L  +  EF+ + + +QST        H+       ++ +++K   K+ +    H      
Sbjct: 958  LSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVS 1017

Query: 409  -------NRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYC 461
                   N  +L+HGS   N   I+  G           G MFG GIYFA+ SSKS  Y 
Sbjct: 1018 EENHNHANERMLFHGSPFVN--AIIHKGF---DERHAYIGGMFGAGIYFAENSSKSNQYV 1072

Query: 462  FASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGS 521
            +      TG  +  + +   C+  L                  LGK   S   F  +  +
Sbjct: 1073 YGIG-GGTGCPVHKDRSCYICHRQL------------LFCRVTLGK---SFLQFSAMKMA 1116

Query: 522  TVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQ 563
              P G  S TG  + +G  L   EY++Y   Q    YL+  Q
Sbjct: 1117 HSPPGHHSVTGRPSVNGLAL--AEYVIYRGEQAYPEYLITYQ 1156


>gi|94536838 poly (ADP-ribose) polymerase family, member 6 [Homo
           sapiens]
          Length = 630

 Score = 38.9 bits (89), Expect = 0.013
 Identities = 40/158 (25%), Positives = 60/158 (37%), Gaps = 25/158 (15%)

Query: 309 RTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQHY---RNLHCALRPLDHESYE 365
           R QK L   + + E      + IK    +L    HPL Q        H    PL    + 
Sbjct: 381 RLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQWIISSNRSHIVKLPLSRLKF- 439

Query: 366 FKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFR--EDLHNRMLLWHGSRMSNWV 423
                          H+ +   LL         ++  FR  + L+     +HGS + NW 
Sbjct: 440 --------------MHTSHQFLLLS----SPPAKEARFRTAKKLYGSTFAFHGSHIENWH 481

Query: 424 GILSHGL-RIAPPEAPITGYMFGKGIYFADMSSKSANY 460
            IL +GL   +  +  + G  +GKGIY + +SS S  Y
Sbjct: 482 SILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGY 519


>gi|154354979 myosin X [Homo sapiens]
          Length = 2058

 Score = 38.1 bits (87), Expect = 0.022
 Identities = 27/123 (21%), Positives = 61/123 (49%), Gaps = 14/123 (11%)

Query: 169 DKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDL----- 223
           +K K   E+++K E+   + +  + +     Q EEET+K++ L++  K + + +L     
Sbjct: 820 EKKKQEEEEKKKREEEERERERERREAELRAQQEEETRKQQELEALQKSQKEAELTRELE 879

Query: 224 ------RVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIR 277
                 +V+E+++L   ++ ++ M  + + +  +A L KL   Q +   +  +  E+  R
Sbjct: 880 KQKENKQVEEILRLEKEIEDLQRMKEQQELSLTEASLQKL---QERRDQELRRLEEEACR 936

Query: 278 AGQ 280
           A Q
Sbjct: 937 AAQ 939


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 36.2 bits (82), Expect = 0.083
 Identities = 51/239 (21%), Positives = 92/239 (38%), Gaps = 41/239 (17%)

Query: 13   RARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKDRTEDKQDESVKA 72
            R RA  E KR        ++     +  R   QE +K+  A  K  +D  E  Q E    
Sbjct: 1579 RKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAE---- 1634

Query: 73   LLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYLIQLLEDDAQRNF 132
                GK     E  A+ G+                            L Q  E  AQ+  
Sbjct: 1635 ----GKFAQKEETLAQRGEK---------------------------LSQEAEKLAQKRK 1663

Query: 133  SVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF--LDKTKNN--WEDREKFEKVPG-K 187
             +  +W +V +  +  L    G L + K I  +K   L + + N  W+++E  +++   +
Sbjct: 1664 KLAKKWEKVARE-EEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELE 1722

Query: 188  YDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAMEEMMMEMK 246
            +DM ++ +     ++EE K  E  K   + E  L  + ++L +    +   EE++++ K
Sbjct: 1723 WDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEK 1781



 Score = 29.6 bits (65), Expect = 7.8
 Identities = 24/74 (32%), Positives = 34/74 (45%), Gaps = 7/74 (9%)

Query: 160  KEIFQKKFLDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESL-------K 212
            KE  +KK   K K   E +EK E    K +++  +   +  DEEE ++  SL       K
Sbjct: 2282 KEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREK 2341

Query: 213  SPLKPESQLDLRVQ 226
              LK E Q  L+ Q
Sbjct: 2342 EILKKEKQFKLQEQ 2355


>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
          Length = 1780

 Score = 35.4 bits (80), Expect = 0.14
 Identities = 32/138 (23%), Positives = 59/138 (42%), Gaps = 23/138 (16%)

Query: 176  EDREKFEKVPGKYDMLQMDYATNTQDEEETKKEE---------SLKSPLKPESQLDLRVQ 226
            EDRE+F K   + ++L         D ++ ++E           LK+ +    Q D  ++
Sbjct: 1449 EDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIE 1508

Query: 227  ELIKLICNVQAMEEMMMEMK-YNTKKAPLGKLTVAQIKAGYQ-SLKKIEDCIRAGQHGRA 284
            +L ++I     +E  +M++K      A   KL    +   ++ S  KIED       G  
Sbjct: 1509 QLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIED-------GSV 1561

Query: 285  LMEAC-----NEFYTRIP 297
            ++++C     N+  TR P
Sbjct: 1562 VLDSCEVSTENDQSTRFP 1579


>gi|22035679 AT rich interactive domain 4B isoform 2 [Homo sapiens]
          Length = 1226

 Score = 35.4 bits (80), Expect = 0.14
 Identities = 34/144 (23%), Positives = 70/144 (48%), Gaps = 21/144 (14%)

Query: 168 LDKTKNNWEDREKFEKVPGKYDM-------LQMDYATNTQDEEETKKEESLKSPL----- 215
           L  ++++ ED E+ E   G  DM        ++D+ TN +++  +K+E++  S L     
Sbjct: 621 LQASESSAEDSEQ-EDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKV 679

Query: 216 -------KPESQLDLRVQELIKLIC-NVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQ 267
                  KP S+   R+++ I+++  +    E+ + + + + KK    K +  QIK G +
Sbjct: 680 HADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKR 739

Query: 268 SLKKIEDCIRAGQHGRALMEACNE 291
                E+C++ G  G+   +A N+
Sbjct: 740 RYCNTEECLKTGSPGKKEEKAKNK 763


>gi|22035677 AT rich interactive domain 4B isoform 1 [Homo sapiens]
          Length = 1312

 Score = 35.4 bits (80), Expect = 0.14
 Identities = 34/144 (23%), Positives = 70/144 (48%), Gaps = 21/144 (14%)

Query: 168 LDKTKNNWEDREKFEKVPGKYDM-------LQMDYATNTQDEEETKKEESLKSPL----- 215
           L  ++++ ED E+ E   G  DM        ++D+ TN +++  +K+E++  S L     
Sbjct: 707 LQASESSAEDSEQ-EDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKV 765

Query: 216 -------KPESQLDLRVQELIKLIC-NVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQ 267
                  KP S+   R+++ I+++  +    E+ + + + + KK    K +  QIK G +
Sbjct: 766 HADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKR 825

Query: 268 SLKKIEDCIRAGQHGRALMEACNE 291
                E+C++ G  G+   +A N+
Sbjct: 826 RYCNTEECLKTGSPGKKEEKAKNK 849


>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
           sapiens]
          Length = 1031

 Score = 35.0 bits (79), Expect = 0.19
 Identities = 18/64 (28%), Positives = 33/64 (51%), Gaps = 5/64 (7%)

Query: 5   RRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKDRTED 64
           RRRS    R R+ + S+           SSP  K+++ + +   K    GG+++K++ +D
Sbjct: 82  RRRSRSRDRRRSRSRSR-----GRRSRSSSPGNKSKKTENRSRSKEKTDGGESSKEKKKD 136

Query: 65  KQDE 68
           K D+
Sbjct: 137 KDDK 140


>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
          Length = 1758

 Score = 33.9 bits (76), Expect = 0.41
 Identities = 21/85 (24%), Positives = 40/85 (47%), Gaps = 6/85 (7%)

Query: 178  REKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQA 237
            +E  E  P K + ++ DY+ + + E+ T KEE  K P +    LD + ++        + 
Sbjct: 1063 KEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEK------RKRK 1116

Query: 238  MEEMMMEMKYNTKKAPLGKLTVAQI 262
             EE  ++  + +    + KL V +I
Sbjct: 1117 TEEKGVDKDFESSSMKISKLEVTEI 1141


>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
          Length = 1792

 Score = 33.9 bits (76), Expect = 0.41
 Identities = 21/85 (24%), Positives = 40/85 (47%), Gaps = 6/85 (7%)

Query: 178  REKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQA 237
            +E  E  P K + ++ DY+ + + E+ T KEE  K P +    LD + ++        + 
Sbjct: 1097 KEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEK------RKRK 1150

Query: 238  MEEMMMEMKYNTKKAPLGKLTVAQI 262
             EE  ++  + +    + KL V +I
Sbjct: 1151 TEEKGVDKDFESSSMKISKLEVTEI 1175


>gi|30794488 kinesin family member 27 [Homo sapiens]
          Length = 1401

 Score = 33.9 bits (76), Expect = 0.41
 Identities = 34/167 (20%), Positives = 73/167 (43%), Gaps = 23/167 (13%)

Query: 190 MLQMDYATNTQDEEETKKEES---------LKSP-----------LKPESQLDLRVQELI 229
           +L   ++ N+ DEE   +E+S         ++ P            + E+Q      E +
Sbjct: 637 VLHCQFSDNSDDEESEGQEKSGTRCRSRSWIQKPDSVCSLVELSDTQDETQKSDLENEDL 696

Query: 230 KLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKK-IEDCIRAGQHGRALMEA 288
           K+ C  ++ E  + ++K + +     K  + ++    +  +  I++ I+ G   +++ + 
Sbjct: 697 KIDCLQESQELNLQKLKNSERILTEAKQKMRELTINIKMKEDLIKELIKTGNDAKSVSKQ 756

Query: 289 CNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVK 335
            +   T++ HD       LI TQK+L E     + L D+ + +KL K
Sbjct: 757 YSLKVTKLEHDAEQAKVELIETQKQLQELEN--KDLSDVAMKVKLQK 801


>gi|110618244 retinoblastoma binding protein 2 isoform 1 [Homo
           sapiens]
          Length = 1690

 Score = 33.1 bits (74), Expect = 0.70
 Identities = 31/132 (23%), Positives = 61/132 (46%), Gaps = 17/132 (12%)

Query: 217 PESQLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLG-----KLTVAQIKAGYQSLKK 271
           PE+ L  ++++ +K      ++ ++++  K   +++P       KLTV ++KA  Q L  
Sbjct: 776 PENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQSPDSGRTRTKLTVEELKAFVQQLFS 835

Query: 272 IEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGD---IE 328
           +   I   +  + L++   EF+ R        TP         S K+Q+L  +G    +E
Sbjct: 836 LPCVISQARQVKNLLDDVEEFHERAQEAMMDETPD--------SSKLQMLIDMGSSLYVE 887

Query: 329 I-AIKLVKTELQ 339
           +  +  +K ELQ
Sbjct: 888 LPELPRLKQELQ 899


>gi|110618242 retinoblastoma binding protein 2 isoform 2 [Homo
           sapiens]
          Length = 1641

 Score = 33.1 bits (74), Expect = 0.70
 Identities = 31/132 (23%), Positives = 61/132 (46%), Gaps = 17/132 (12%)

Query: 217 PESQLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLG-----KLTVAQIKAGYQSLKK 271
           PE+ L  ++++ +K      ++ ++++  K   +++P       KLTV ++KA  Q L  
Sbjct: 776 PENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQSPDSGRTRTKLTVEELKAFVQQLFS 835

Query: 272 IEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGD---IE 328
           +   I   +  + L++   EF+ R        TP         S K+Q+L  +G    +E
Sbjct: 836 LPCVISQARQVKNLLDDVEEFHERAQEAMMDETPD--------SSKLQMLIDMGSSLYVE 887

Query: 329 I-AIKLVKTELQ 339
           +  +  +K ELQ
Sbjct: 888 LPELPRLKQELQ 899


>gi|58535453 CDK5 regulatory subunit associated protein 2 isoform b
            [Homo sapiens]
          Length = 1814

 Score = 32.0 bits (71), Expect = 1.6
 Identities = 29/126 (23%), Positives = 58/126 (46%), Gaps = 11/126 (8%)

Query: 169  DKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQEL 228
            DK K N + RE   +     + LQ +YA+  ++ E  +KE S K         +   Q+L
Sbjct: 1472 DKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEK---------ERHNQQL 1522

Query: 229  IKLI-CNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHG-RALM 286
            I+ + C+ Q +  +  E+K   +        +  ++   ++ +K+++  R  + G +  M
Sbjct: 1523 IQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPM 1582

Query: 287  EACNEF 292
            E+ N F
Sbjct: 1583 ESDNSF 1588


>gi|15559211 RE1-silencing transcription factor [Homo sapiens]
          Length = 1097

 Score = 32.0 bits (71), Expect = 1.6
 Identities = 22/68 (32%), Positives = 33/68 (48%), Gaps = 8/68 (11%)

Query: 19  ESKRVNNGNTAPEDSSPA---KKTRRCQRQESKKMPVAGGKANKDRTEDKQDESVKALLL 75
           ESK  NN    P+  S     KK   C ++ +KK  +   K++K  ++  Q E V+    
Sbjct: 548 ESKSKNNSQEVPKGDSKVEENKKQNTCMKKSTKKKTLK-NKSSKKSSKPPQKEPVE---- 602

Query: 76  KGKAPVDP 83
           KG A +DP
Sbjct: 603 KGSAQMDP 610


>gi|239758013 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 819

 Score = 32.0 bits (71), Expect = 1.6
 Identities = 20/65 (30%), Positives = 31/65 (47%), Gaps = 5/65 (7%)

Query: 2   AARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQE-----SKKMPVAGGK 56
           +A   +S GGG  + L E+KR  +G   P   +P ++ ++    +     SKK    G K
Sbjct: 374 SAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPK 433

Query: 57  ANKDR 61
           A K R
Sbjct: 434 AAKSR 438


>gi|194328777 poly (ADP-ribose) polymerase family, member 11 [Homo
           sapiens]
          Length = 338

 Score = 32.0 bits (71), Expect = 1.6
 Identities = 33/129 (25%), Positives = 56/129 (43%), Gaps = 15/129 (11%)

Query: 344 PLDQHYRNLHCA----LRPLDHESYEFKVISQYLQSTHAPTHSDYTMTL--LDLFEV--- 394
           P+  H+ N++      L PL ++++E+  ++     T           +  LDL+E    
Sbjct: 124 PMPPHWENVNTQVPYQLIPLHNQTHEYNEVANLFGKTMDRNRIKRIQRIQNLDLWEFFCR 183

Query: 395 EKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGL--RIAPPEAPITGYMFGKGIYFAD 452
           +K   K+       N  +L+HG+       I  H    RI      I G +FGKG YFA 
Sbjct: 184 KKAQLKKKRGVPQINEQMLFHGTSSEFVEAICIHNFDWRING----IHGAVFGKGTYFAR 239

Query: 453 MSSKSANYC 461
            ++ S+ +C
Sbjct: 240 DAAYSSRFC 248


>gi|4505531 oxysterol binding protein [Homo sapiens]
          Length = 807

 Score = 32.0 bits (71), Expect = 1.6
 Identities = 30/122 (24%), Positives = 51/122 (41%), Gaps = 9/122 (7%)

Query: 142 GKMGQHSLVACSGNLNKAKEIFQKKFLDKTK-----NNWEDREKFEKVPGKYDMLQMDYA 196
           G +G      CSG  + + E  + +F D  +      N   +     + G    + +D  
Sbjct: 334 GNVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQ 393

Query: 197 TNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGK 256
              Q  EETKKE+  + P KP   L+L     I   C  + + ++ M + +N   + L +
Sbjct: 394 YKHQ-LEETKKEKRTRIPYKPNYSLNL---WSIMKNCIGKELSKIPMPVNFNEPLSMLQR 449

Query: 257 LT 258
           LT
Sbjct: 450 LT 451


>gi|122937211 KIAA0368 protein [Homo sapiens]
          Length = 2017

 Score = 32.0 bits (71), Expect = 1.6
 Identities = 57/214 (26%), Positives = 84/214 (39%), Gaps = 48/214 (22%)

Query: 146  QHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDR-EKFEKVPG---KYDMLQMDYATNTQD 201
            Q  L  CS    K K +      D  K   EDR ++F  +     K + L+      T++
Sbjct: 1790 QAVLKECSKENVKYKIVAISCAADILKATKEDRFQEFSNIVIPLIKKNSLESSGVRTTKN 1849

Query: 202  EEETKKEESLKS--------------PLKPESQLDLRVQELIKLICNVQAMEEMMMEMKY 247
            EEE +KE+ L+               P   E+Q   R QEL KL+C           +K 
Sbjct: 1850 EEENEKEKELQLEYLLGAFESLGKAWPRNAETQRCYR-QELCKLMCE---------RLKL 1899

Query: 248  NTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHG--RALMEACNEFYTRIPHDFGLRTP 305
            +T K  LG L    + A +Q L  +E+     +H    AL E   E    I +    +T 
Sbjct: 1900 STWKVQLGVL--QSMNAFFQGLMLLEE-----EHADPEALAEILLETCKSITYSLENKTY 1952

Query: 306  PLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQ 339
              +RT           EAL  IE+ +K ++   Q
Sbjct: 1953 SSVRT-----------EALSVIELLLKKLEESKQ 1975


>gi|38524594 TCDD-inducible poly(ADP-ribose) polymerase [Homo
           sapiens]
          Length = 657

 Score = 31.6 bits (70), Expect = 2.0
 Identities = 25/80 (31%), Positives = 37/80 (46%), Gaps = 7/80 (8%)

Query: 404 REDLHNRMLLWHGSRMSNWVGILSHGL--RIAPPEAPITGYMFGKGIYFADMSSKSANYC 461
           R+ + N   L+HG+      GI  H    R+    A     MFG+G YFA  +S S N+ 
Sbjct: 521 RDRIINERHLFHGTSQDVVDGICKHNFDPRVCGKHAT----MFGQGSYFAKKASYSHNFS 576

Query: 462 FASRLKNTGLLLLSEVALGQ 481
             S  K    + L++V  G+
Sbjct: 577 KKSS-KGVHFMFLAKVLTGR 595


>gi|42476024 THUMP domain containing 1 [Homo sapiens]
          Length = 353

 Score = 31.6 bits (70), Expect = 2.0
 Identities = 33/133 (24%), Positives = 58/133 (43%), Gaps = 14/133 (10%)

Query: 165 KKFLDKTKNNWED-REKFEKVPGKYDMLQMDYATNTQD----EEETKKEESLKSPLKPES 219
           K FL+  K   E   E + K P K    Q+ Y +        EE  ++   +   L  E+
Sbjct: 170 KAFLEDMKKYAETFLEPWFKAPNK-GTFQIVYKSRNNSHVNREEVIRELAGIVCTLNSEN 228

Query: 220 QLDLR------VQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQI--KAGYQSLKK 271
           ++DL       V E+IK +C +  +++ M+  KYN ++        +Q+  K G     K
Sbjct: 229 KVDLTNPQYTVVVEIIKAVCCLSVVKDYMLFRKYNLQEVVKSPKDPSQLNSKQGNGKEAK 288

Query: 272 IEDCIRAGQHGRA 284
           +E   ++ Q+  A
Sbjct: 289 LESADKSDQNNTA 301


>gi|58535451 CDK5 regulatory subunit associated protein 2 isoform a
            [Homo sapiens]
          Length = 1893

 Score = 31.2 bits (69), Expect = 2.7
 Identities = 29/124 (23%), Positives = 56/124 (45%), Gaps = 16/124 (12%)

Query: 169  DKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQEL 228
            DK K N + RE   +     + LQ +YA+  ++ E  +KE S K         +   Q+L
Sbjct: 1472 DKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEK---------ERHNQQL 1522

Query: 229  IKLI-CNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME 287
            I+ + C+ Q +  +  E+K   +        +  ++   ++ +K+++     +H R L E
Sbjct: 1523 IQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDE-----EH-RRLRE 1576

Query: 288  ACNE 291
            A  E
Sbjct: 1577 ASGE 1580


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,894,142
Number of Sequences: 37866
Number of extensions: 1001394
Number of successful extensions: 3819
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 3743
Number of HSP's gapped (non-prelim): 92
length of query: 570
length of database: 18,247,518
effective HSP length: 108
effective length of query: 462
effective length of database: 14,157,990
effective search space: 6540991380
effective search space used: 6540991380
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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