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Search of human proteins with 167555127
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|167555127 CD180 molecule [Homo sapiens]
(661 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|167555127 CD180 molecule [Homo sapiens] 1333 0.0
gi|19924149 toll-like receptor 4 precursor [Homo sapiens] 228 1e-59
gi|4507531 toll-like receptor 3 [Homo sapiens] 145 9e-35
gi|20302168 toll-like receptor 8 [Homo sapiens] 102 1e-21
gi|188528675 slit homolog 1 [Homo sapiens] 102 1e-21
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 97 6e-20
gi|225579152 insulin-like growth factor binding protein, acid la... 96 1e-19
gi|4826772 insulin-like growth factor binding protein, acid labi... 96 1e-19
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 92 1e-18
gi|4759146 slit homolog 2 [Homo sapiens] 92 2e-18
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 91 3e-18
gi|7706093 toll-like receptor 7 [Homo sapiens] 89 1e-17
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 89 2e-17
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 88 2e-17
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 87 4e-17
gi|11321571 slit homolog 3 [Homo sapiens] 87 6e-17
gi|38348406 leucine rich repeat containing 33 [Homo sapiens] 84 4e-16
gi|16751843 toll-like receptor 5 [Homo sapiens] 83 9e-16
gi|51317373 netrin-G1 ligand [Homo sapiens] 83 9e-16
gi|198041768 synleurin [Homo sapiens] 81 3e-15
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 81 3e-15
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 81 3e-15
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 79 2e-14
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor... 79 2e-14
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor... 79 2e-14
gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens] 77 4e-14
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 77 5e-14
gi|4503743 flightless I homolog [Homo sapiens] 77 7e-14
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 77 7e-14
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 76 9e-14
>gi|167555127 CD180 molecule [Homo sapiens]
Length = 661
Score = 1333 bits (3450), Expect = 0.0
Identities = 661/661 (100%), Positives = 661/661 (100%)
Query: 1 MAFDVSCFFWVVLFSAGCKVITSWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEF 60
MAFDVSCFFWVVLFSAGCKVITSWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEF
Sbjct: 1 MAFDVSCFFWVVLFSAGCKVITSWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEF 60
Query: 61 SFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETS 120
SFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETS
Sbjct: 61 SFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETS 120
Query: 121 LNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDF 180
LNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDF
Sbjct: 121 LNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDF 180
Query: 181 QNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFN 240
QNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFN
Sbjct: 181 QNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFN 240
Query: 241 GLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQL 300
GLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQL
Sbjct: 241 GLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQL 300
Query: 301 QELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLH 360
QELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLH
Sbjct: 301 QELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLH 360
Query: 361 LGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECP 420
LGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECP
Sbjct: 361 LGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECP 420
Query: 421 QLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNH 480
QLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNH
Sbjct: 421 QLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNH 480
Query: 481 FQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSL 540
FQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSL
Sbjct: 481 FQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSL 540
Query: 541 SHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLE 600
SHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLE
Sbjct: 541 SHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLE 600
Query: 601 GSEETTCANPPSLRGVKLSDVKLSCGITAIGIFFLIVFLLLLAILLFFAVKYLLRWKYQH 660
GSEETTCANPPSLRGVKLSDVKLSCGITAIGIFFLIVFLLLLAILLFFAVKYLLRWKYQH
Sbjct: 601 GSEETTCANPPSLRGVKLSDVKLSCGITAIGIFFLIVFLLLLAILLFFAVKYLLRWKYQH 660
Query: 661 I 661
I
Sbjct: 661 I 661
>gi|19924149 toll-like receptor 4 precursor [Homo sapiens]
Length = 839
Score = 228 bits (582), Expect = 1e-59
Identities = 188/642 (29%), Positives = 302/642 (47%), Gaps = 31/642 (4%)
Query: 23 SWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFL 82
SW+ C+E N TY C L +IPD LP +T+ L+ SFN L + + +F L L
Sbjct: 25 SWEP-CVEVVPNITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVL 83
Query: 83 DLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEF 142
DL+RC+I I + +QS LSTL+LTGNP+ +A + +G SL+ L ++T +++LE
Sbjct: 84 DLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLEN 143
Query: 143 IPVHNLENLESLYLGSNHISSIKFPKDFP-ARNLKVLDFQNNAIHYISREDMRSLEQA-- 199
P+ +L+ L+ L + N I S K P+ F NL+ LD +N I I D+R L Q
Sbjct: 144 FPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPL 203
Query: 200 INLSLNFNGNNVKGIELGAFDSTIFQSL----NFGGTPNLSVIFNGLQNSTTQSLWLGTF 255
+NLSL+ + N + I+ GAF L NF + GL L LG F
Sbjct: 204 LNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEF 263
Query: 256 EDIDD-EDISSAMLKGLCEMSVESLNLQ--EHRFSDISSTTFQCFTQLQELDLTATHLKG 312
+ + E + L+GLC +++E L ++ DI F C T + L + ++
Sbjct: 264 RNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDL-FNCLTNVSSFSLVSVTIER 322
Query: 313 LPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNL 372
+ + L L F Q + + LT +G + L +L
Sbjct: 323 VKDFSYNFGW-QHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVD------LPSL 375
Query: 373 QTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRL 432
+ LDLS N + CCS + L+ L+LS N + + S F QLE LD + L
Sbjct: 376 EFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSN-FLGLEQLEHLDFQHSNL 434
Query: 433 HINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLL 492
+ S F +L L L++++ + + GL L L + GN FQ+ + ++
Sbjct: 435 KQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLP--DIF 492
Query: 493 QTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAA 552
+ +L L LS C L + AF+SL + +++SHN+ S+D+ + L +
Sbjct: 493 TELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFF--SLDTFPYKCLNSLQVLD 550
Query: 553 NSINII----SPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCA 608
S+N I L S + +NL+ N CTC + FL W K+ L E CA
Sbjct: 551 YSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECA 610
Query: 609 NPPSLRGVKLSDVKLSCGI--TAIGIFFLIVFLL-LLAILLF 647
P +G+ + + ++C + T IG+ L V ++ ++A+L++
Sbjct: 611 TPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVY 652
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 145 bits (367), Expect = 9e-35
Identities = 179/730 (24%), Positives = 285/730 (39%), Gaps = 89/730 (12%)
Query: 8 FFWVVLFSAGCKVITSWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPT 67
+FW L G +S + + E +C +L L+++PD LP L + N L
Sbjct: 9 YFWGGLLPFGMLCASSTTKCTVSHEVA---DCSHLKLTQVPDDLPTNITVLNLTHNQLRR 65
Query: 68 IHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSL 127
+ F+R LT LD+ I+ + + Q L L L N L +++ + +L
Sbjct: 66 LPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNL 125
Query: 128 KHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHY 187
L L+ I ++ P +NL +L L N +SS K NL+ L NN I
Sbjct: 126 TELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQA 185
Query: 188 ISREDMRSLEQAINLSLNFNGNNVKGIELGAF---------------------------- 219
+ E++ + L + N +K G F
Sbjct: 186 LKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLEL 245
Query: 220 ------------------DSTIFQSLNFGGTPNLSVIFNGLQNSTTQSL-WLGTFEDI-- 258
+T F L + L + +N L S WL E
Sbjct: 246 ANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFL 305
Query: 259 ---DDEDISSAMLKGLCEMSVESLNLQEH---------RFSDISSTTFQCFTQLQELDLT 306
+ + + S L GL +V LNL+ I +FQ L+ L++
Sbjct: 306 EYNNIQHLFSHSLHGL--FNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNME 363
Query: 307 ATHLKGLPSGM-KGLNLLKKLVLSVNHFDQLCQISAANFPSLTH--LYIRGNVKKL--HL 361
+ G+ S M GL LK L LS N F L ++ F SL H L+I K +
Sbjct: 364 DNDIPGIKSNMFTGLINLKYLSLS-NSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKI 422
Query: 362 GVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQ 421
LG+L+ LDL N+I + + + L ++ + LS+N+ L L +F P
Sbjct: 423 ESDAFSWLGHLEVLDLGLNEI-GQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPS 481
Query: 422 LELLDLAFTRL-HINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGN- 479
L+ L L L ++++ SPFQ L L +L+L+ + N +L GL L L+L+ N
Sbjct: 482 LQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNN 541
Query: 480 ------HFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLT 533
H G L+ + L +L L S G I + F L ++ +DL N+L
Sbjct: 542 LARLWKHANPGG--PIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLN 599
Query: 534 CDSIDSLSHLKGIY-LNLAANSINIISPRLL-PILSQQSTINLSHNPLDCTCSNI-HFLT 590
++ + LNL N I + ++ P + +++ NP DCTC +I F+
Sbjct: 600 TLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVN 659
Query: 591 WYKENLHKL-EGSEETTCANPPSLRG--VKLSDVKLSCGITAIGIFFLIVFLLLLAILLF 647
W E + E S C PP G V+L D +FF+I +LL +
Sbjct: 660 WINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFI 719
Query: 648 FAVKYLLRWK 657
+ + W+
Sbjct: 720 VLLIHFEGWR 729
>gi|20302168 toll-like receptor 8 [Homo sapiens]
Length = 1041
Score = 102 bits (254), Expect = 1e-21
Identities = 195/855 (22%), Positives = 319/855 (37%), Gaps = 214/855 (25%)
Query: 5 VSCFFWVVLFSAGCKVIT----SWDQMCIEKEANKTY--NCENLGLSEIPDTLPNTTEFL 58
++C F +L S C++ S C EK+ N + C N L E+P T+ L
Sbjct: 11 LTCIF--LLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTEL 68
Query: 59 EFSFNFLPTIHNRTFSRLMNLTFLDLTR------------CQINWIH--EDTFQSHHQLS 104
+ S NF+ I N +F L NLT ++L Q N ++ + F + L
Sbjct: 69 DLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLR 128
Query: 105 TLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSN----- 159
L+L N L + P+SL L LIQ I N+ + L NL++LYL N
Sbjct: 129 ELLLEDNQL---PQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNK 185
Query: 160 ------------------HISSIKF------PKDFPARNLKVLDFQNNAIHYISREDMRS 195
+ S+ F P P+ +L+ L N I YIS ED +
Sbjct: 186 VCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPS-SLRKLFLSNTQIKYISEEDFKG 244
Query: 196 LEQAINLS-LNFNGN----------------------------NVKGIELGAFDSTIFQS 226
L INL+ L+ +GN N+ + ST +
Sbjct: 245 L---INLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRK 301
Query: 227 LN---FGGTPNLSVI---FNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCE------- 273
+N F P+L V+ FN L +L ++ D+S +KG
Sbjct: 302 INAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISR 361
Query: 274 -----MSVESLNLQEHRFSDISSTTFQCFTQLQEL---DLTATHLKGLPSGM-KGLNLLK 324
+S+ +L+L+ + F ++ FQ QL L +L +K + + + + L+
Sbjct: 362 NFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLE 421
Query: 325 KLVLSVNHFDQLCQISA--------------------------ANFPSLTHLYIR----- 353
+ LS N L + + +NF T I+
Sbjct: 422 IIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAA 481
Query: 354 -GNVKKLHL------GVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHN 406
G L L G E L ++ L+LS N A + + H++ L+L++N
Sbjct: 482 YGKALDLSLNSIFFIGPNQFENLPDIACLNLSANS-NAQVLSGTEFSAIPHVKYLDLTNN 540
Query: 407 EPLGLQSQAFKECPQLELLDLAFTRLH-----INAPQSPFQNLHFLQVLNLTY------- 454
+ A E LE+LDL++ + + QN L+VLNL++
Sbjct: 541 RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT 600
Query: 455 ----------------------CFLDTSNQH--LLAGLPVLRHLNLKGN----------- 479
+ D N++ + GL L L+L N
Sbjct: 601 DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL 660
Query: 480 ---------HFQDGTITKTN--LLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLS 528
H D + N LLQ LE+L L LL + + + LS
Sbjct: 661 NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS 720
Query: 529 HNSLTCDSIDSLSHLKGI-YLNLAANSINIISPRLL--PILSQQSTINLSHNPLDCTCSN 585
HN ++ LS + + +L+L++N + I+ L ++ S + L NP +CTC
Sbjct: 721 HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI 780
Query: 586 IHFLTWYKENLH-KLEGSEETTCANPPSLRGVKLSDVKLS---CGITAIGIFFLIVFLLL 641
F W E+L+ K+ + CA+P RG + ++L+ +TA+ +FF F+
Sbjct: 781 GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT 840
Query: 642 LAILLFFAVKYLLRW 656
+ +L A +L W
Sbjct: 841 MVMLAALA-HHLFYW 854
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 102 bits (254), Expect = 1e-21
Identities = 160/710 (22%), Positives = 270/710 (38%), Gaps = 114/710 (16%)
Query: 10 WVVLFSAGCKV-ITSWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTI 68
W++L++A ++ ++ +C T +C GL IP +P TE LE + N + I
Sbjct: 19 WLLLWAAAWRLGASACPALCTC--TGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRI 76
Query: 69 HNRTFSRLMNLTFLDL------------------------TRCQINWIHEDTFQSHHQLS 104
H F+ L L L L R Q++ + E FQ++ LS
Sbjct: 77 HKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALS 136
Query: 105 TLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSI 164
L L+ N + + + G LK+L L + IS +E L LE L L +N+I++I
Sbjct: 137 RLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTI 196
Query: 165 KFPKDFPARNLKVLDFQNNAI----HYISREDMRSLEQAINLSLNFNGN-NVKGIELGAF 219
L+ +N + H I L +G +++G+ +
Sbjct: 197 PVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEV 256
Query: 220 DSTIFQ-------------SLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSA 266
+ F +L+ G P + NG+ + + L +
Sbjct: 257 QKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRL 316
Query: 267 MLKGLCEM---------SVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGM 317
L G+ + + ++L ++ ++I+ FQ L L L + LP G+
Sbjct: 317 ELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGV 376
Query: 318 -KGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLD 376
GL L+ L+L+ N + + + + +L+ L + N K L G L +QTL
Sbjct: 377 FGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDN-KIQSLAKGTFTSLRAIQTLH 435
Query: 377 LSHND------------------IEASD--CCS---LQLKNLSHLQTLN----------L 403
L+ N IE S C S L K + +++ +
Sbjct: 436 LAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFI 495
Query: 404 SHNEPLGLQSQAFKE--CPQ--------LELLDLAFTRLHINAPQSPFQNLHFLQVLNLT 453
E L S+ + CP +E L T++ PQS + L++ N
Sbjct: 496 PGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAE----LRLNNNE 551
Query: 454 YCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQ 513
L+ + + L L+ +NL N + + + S+ L L++ L SI
Sbjct: 552 ISILEATG--MFKKLTHLKKINLSNNKVSE---IEDGAFEGAASVSELHLTANQLESIRS 606
Query: 514 QAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGI-YLNLAANSINIISPRLLPILSQQSTI 572
F L + + L +N ++C DS + L+ + L+L N I +SP L ST+
Sbjct: 607 GMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTL 666
Query: 573 NLSHNPLDCTCSNIHFLTWYKENLHKLE-GSEETTCANPPSLRGVKLSDV 621
NL NP +C C L W L K + + C NP LR + L DV
Sbjct: 667 NLLANPFNCNCQ----LAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDV 712
Score = 75.9 bits (185), Expect = 1e-13
Identities = 135/569 (23%), Positives = 234/569 (41%), Gaps = 50/569 (8%)
Query: 63 NFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLN 122
N + + F L L L L +IN I D FQ LS L L N + +A+ +
Sbjct: 367 NKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFT 426
Query: 123 GPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPAR--NLKVLDF 180
++++ L L Q FI NL+ L +L +N I + P R N ++
Sbjct: 427 SLRAIQTLHLAQN-----PFICDCNLKWLAD-FLRTNPIETSGARCASPRRLANKRIGQI 480
Query: 181 QNNAIHYISREDMRSLEQAINLSLNFNGNN-VKGIELGAFDSTIFQSLNFGGTPNLSVIF 239
++ ++E + + LN N+ V ++ + + + L+ I
Sbjct: 481 KSKKFRCSAKEQY-FIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSL----KLTKIP 535
Query: 240 NGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEM--SVESLNLQEHRFSDISSTTFQCF 297
+ ST + +++ +IS G+ + ++ +NL ++ S+I F+
Sbjct: 536 ERIPQSTAELR-------LNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGA 588
Query: 298 TQLQELDLTATHLKGLPSGM-KGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNV 356
+ EL LTA L+ + SGM +GL+ L+ L+L N + S ++ L + N
Sbjct: 589 ASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDN- 647
Query: 357 KKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSH-LQTLNLSHNEPLGLQSQA 415
+ + G + L +L TL+L N C+ QL L L+ + P
Sbjct: 648 QITTVSPGAFDTLQSLSTLNLLANPFN----CNCQLAWLGGWLRKRKIVTGNPRCQNPDF 703
Query: 416 FKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDT----SNQHLLA---GL 468
++ P L D+AF Q L Q C LDT SN+HL A G+
Sbjct: 704 LRQIP---LQDVAFPDFRCEEGQEEGGCLPRPQCPQECAC-LDTVVRCSNKHLRALPKGI 759
Query: 469 PV-LRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDL 527
P + L L GN F L T L+++ LS+ + S+ +F ++ +++ + L
Sbjct: 760 PKNVTELYLDGNQFT----LVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLIL 815
Query: 528 SHNSLTCDSIDSLSHLKGI-YLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNI 586
S+N+L C + L+ + L+L N I+ + + ++ S + + NPL C C
Sbjct: 816 SYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLR 875
Query: 587 HFLTWYKENLHKLEGSEETTCANPPSLRG 615
+W K +K G CA P + G
Sbjct: 876 WLSSWVKTG-YKEPGI--ARCAGPQDMEG 901
Score = 50.8 bits (120), Expect = 4e-06
Identities = 52/205 (25%), Positives = 84/205 (40%), Gaps = 11/205 (5%)
Query: 421 QLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNH 480
+LEL TR+H N F L L+VL L + + + L L L N
Sbjct: 65 RLELNGNNITRIHKN----DFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ 120
Query: 481 FQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSL 540
+ L Q +L L LS + +I ++AF + ++ L N ++C +
Sbjct: 121 LH---MLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAF 177
Query: 541 SHLKGI-YLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKL 599
L+G+ L L N+I I + + T L N L C C W ++ +
Sbjct: 178 RALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQ---RP 234
Query: 600 EGSEETTCANPPSLRGVKLSDVKLS 624
T C+ P SLRG+ +++V+ S
Sbjct: 235 TIGLFTQCSGPASLRGLNVAEVQKS 259
Score = 41.6 bits (96), Expect = 0.002
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 1/121 (0%)
Query: 39 CENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQ 98
C N L +P +P L N + + S L +DL+ +I+ + +F
Sbjct: 747 CSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQ-LSTFKYLQLVDLSNNKISSLSNSSFT 805
Query: 99 SHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGS 158
+ QL+TL+L+ N L + + G +SL+ L L IS L+ ++ +L L +G+
Sbjct: 806 NMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGA 865
Query: 159 N 159
N
Sbjct: 866 N 866
Score = 36.6 bits (83), Expect = 0.076
Identities = 101/483 (20%), Positives = 163/483 (33%), Gaps = 133/483 (27%)
Query: 210 NVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLK 269
N + +EL + T +F G L V+ L + ++ G F+D+ +
Sbjct: 62 NTERLELNGNNITRIHKNDFAGLKQLRVL--QLMENQIGAVERGAFDDMKE--------- 110
Query: 270 GLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLP-SGMKGLNLLKKLVL 328
+E L L ++ + FQ L LDL+ ++ +P +G LK L L
Sbjct: 111 ------LERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQL 164
Query: 329 SVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCC 388
N QIS + G L L+ L L++N+I
Sbjct: 165 DKN------QISC-------------------IEEGAFRALRGLEVLTLNNNNITTIPVS 199
Query: 389 SLQLKNLSHLQTLNLSHNE-----PLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQN 443
S ++ L+T L N L SQ ++ P + L FT+ + P S
Sbjct: 200 SFN--HMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGL----FTQC--SGPAS---- 247
Query: 444 LHFLQVLNLTYCFLDTSNQHLLAGLPVLRH---------------LNLKGNHFQDGTITK 488
L L V + S Q +P ++ +G T
Sbjct: 248 LRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGL---TAIP 304
Query: 489 TNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLK---- 544
NL +T+ + L G+ SI AF K+ +DLS+N + + D+ L+
Sbjct: 305 ANLPETMTEIR---LELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNS 361
Query: 545 -----------------GIY----LNLAANSINIISPRLLPILSQQS------------- 570
G+Y L L AN IN I P L S
Sbjct: 362 LVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLA 421
Query: 571 -----------TINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLS 619
T++L+ NP C C+ + + N + G+ CA+P L ++
Sbjct: 422 KGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGAR---CASPRRLANKRIG 478
Query: 620 DVK 622
+K
Sbjct: 479 QIK 481
Score = 36.6 bits (83), Expect = 0.076
Identities = 68/326 (20%), Positives = 127/326 (38%), Gaps = 32/326 (9%)
Query: 35 KTYNCENLGLSEIPDTL---PNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINW 91
K N N +SEI D + L + N L +I + F L L L L +I+
Sbjct: 568 KKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISC 627
Query: 92 IHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGIS-NLEFIPVHNLEN 150
IH D+F + L L N + ++ + + +SL L L+ + N + +
Sbjct: 628 IHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLR 687
Query: 151 LESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNN 210
+ G+ + F + P +++ DF+ +E+ L +
Sbjct: 688 KRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEE----GQEEGGCLPRPQCPQ------- 736
Query: 211 VKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKG 270
E D+ + S +L + G+ + T+ G + +S+
Sbjct: 737 ----ECACLDTVVRCS-----NKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKY-- 785
Query: 271 LCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPS-GMKGLNLLKKLVLS 329
++ ++L ++ S +S+++F +QL L L+ L+ +P +GL L+ L L
Sbjct: 786 -----LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLH 840
Query: 330 VNHFDQLCQISAANFPSLTHLYIRGN 355
N L + A+ SL+HL I N
Sbjct: 841 GNDISTLQEGIFADVTSLSHLAIGAN 866
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 96.7 bits (239), Expect = 6e-20
Identities = 127/465 (27%), Positives = 198/465 (42%), Gaps = 63/465 (13%)
Query: 38 NCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTF 97
+C +LGLSE+P L T +L+ S N I + L +L FL+ R
Sbjct: 51 DCSDLGLSELPSNLSVFTSYLDLSMN---NISQLLPNPLPSLRFLEELR----------- 96
Query: 98 QSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLG 157
L GN L ++ + + G SLK L L + ++ + NL +L+SL L
Sbjct: 97 ----------LAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLD 146
Query: 158 SNHISSIKFPKDFPA-RNLKVLDFQNNAIHYISREDMRSLE--QAINLSLNFNGNNVKGI 214
+NHIS + P F +L+ L +NA+ I + RSL QA+ L+LN +++
Sbjct: 147 ANHISYVP-PSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALN-KIHHIPDY 204
Query: 215 ELGAFDSTIFQSLNFGGTPNLSV-IFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCE 273
G S + L+ +L F+GL + T L + ++D+ + L L E
Sbjct: 205 AFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDL---NYNNLDEFPTAIRTLSNLKE 261
Query: 274 MSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKL----VLS 329
+ S N++ I F + L H P G + + L L+
Sbjct: 262 LGFHSNNIRS-----IPEKAF-----VGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLT 311
Query: 330 VNHFDQLCQI----SAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEAS 385
+N Q+ + AN SLT + L V +L NLQ LDLS+N +E
Sbjct: 312 LNGASQITEFPDLTGTANLESLT--LTGAQISSLPQTV--CNQLPNLQVLDLSYNLLEDL 367
Query: 386 DCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLH 445
S+ K LQ ++L HNE ++ F++ L L+LA+ ++ I P + F L
Sbjct: 368 PSFSVCQK----LQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNA-FSTLP 422
Query: 446 FLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTN 490
L L+L+ L + + GL L HL L GNH I+ N
Sbjct: 423 SLIKLDLSSNLLSSFP---ITGLHGLTHLKLTGNHALQSLISSEN 464
Score = 63.5 bits (153), Expect = 6e-10
Identities = 97/384 (25%), Positives = 142/384 (36%), Gaps = 47/384 (12%)
Query: 254 TFEDIDDEDISSAMLKGLCEMS-VESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKG 312
++ D+ +IS + L + +E L L + + I F L+ L L L+
Sbjct: 69 SYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRH 128
Query: 313 LPS-GMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGN 371
+P+ ++ L L+ L L NH + + SL HL++ N + V L
Sbjct: 129 VPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALT-EIPVQAFRSLSA 187
Query: 372 LQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTR 431
LQ + L+ N I NLS L L+L +N L + F LE LDL +
Sbjct: 188 LQAMTLALNKIHHIP--DYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNN 245
Query: 432 L------------------HINAPQSPFQNLHFLQVLNLTYCFLDTSNQHL----LAGLP 469
L H N +S + +T F D Q + LP
Sbjct: 246 LDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLP 305
Query: 470 VLRHLNLKG----NHFQD--GTITKTNLLQTVGSLEVLILSSCGLLS------------I 511
LR L L G F D GT +L T + L + C L
Sbjct: 306 ELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLE 365
Query: 512 DQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGI-YLNLAANSINIISPRLLPILSQQS 570
D +F K+ +DL HN + +D+ L + LNLA N I II P L
Sbjct: 366 DLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLI 425
Query: 571 TINLSHNPLDC-TCSNIHFLTWYK 593
++LS N L + +H LT K
Sbjct: 426 KLDLSSNLLSSFPITGLHGLTHLK 449
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 95.9 bits (237), Expect = 1e-19
Identities = 152/604 (25%), Positives = 234/604 (38%), Gaps = 87/604 (14%)
Query: 39 CENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQ 98
C + L+ +PD +P T+ L N L ++ F L +L FL+L Q+ +
Sbjct: 98 CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 157
Query: 99 SHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGS 158
L L L N L +A + +L L L +S LE L +L L LG
Sbjct: 158 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGW 217
Query: 159 NHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGA 218
N ++ + +L+ L N + Y+ L + L L+ N L A
Sbjct: 218 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNA-------LRA 270
Query: 219 FDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKG--LCEMSV 276
+ +F L P L Q L+L D ++ +A+ G L ++
Sbjct: 271 IKANVFVQL-----PRL------------QKLYL-------DRNLIAAVAPGAFLGLKAL 306
Query: 277 ESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGL-PSGMKGLNLLKKLVLSVNHFDQ 335
L+L +R + + TF L+ L L+ + L P K L+ L++L L N Q
Sbjct: 307 RWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQ 366
Query: 336 LCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNL 395
L + S E LG L+ L L HN ++ + L
Sbjct: 367 LAERS-------------------------FEGLGQLEVLTLDHNQLQEVKAGAFL--GL 399
Query: 396 SHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYC 455
+++ +NLS N L Q F+ +L L L + L P + F L L+ L L
Sbjct: 400 TNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHT-FTGLSGLRRLFLKDN 458
Query: 456 FLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQA 515
L + L GL L L+L N T L Q +G LE L+LS L + A
Sbjct: 459 GLVGIEEQSLWGLAELLELDLTSNQL---THLPHRLFQGLGKLEYLLLSRNRLAELPADA 515
Query: 516 FHSLGKMSHVDLSHNSLTCDSIDSLSHLKGI-YLNLAANSINIISPRLLPILSQQSTINL 574
L + +D+SHN L L+ L + YL+L NS+ +P+ P L + + L
Sbjct: 516 LGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ-PPGLER---LWL 571
Query: 575 SHNPLDCTCSNIHFLTWYKENLHKL--------EGSE---------ETTCANPPSLRGVK 617
NP DC C + +N + EG + TCA+PP + G+
Sbjct: 572 EGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLD 631
Query: 618 LSDV 621
L D+
Sbjct: 632 LRDL 635
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 95.9 bits (237), Expect = 1e-19
Identities = 152/604 (25%), Positives = 234/604 (38%), Gaps = 87/604 (14%)
Query: 39 CENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQ 98
C + L+ +PD +P T+ L N L ++ F L +L FL+L Q+ +
Sbjct: 60 CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 119
Query: 99 SHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGS 158
L L L N L +A + +L L L +S LE L +L L LG
Sbjct: 120 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGW 179
Query: 159 NHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGA 218
N ++ + +L+ L N + Y+ L + L L+ N L A
Sbjct: 180 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNA-------LRA 232
Query: 219 FDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKG--LCEMSV 276
+ +F L P L Q L+L D ++ +A+ G L ++
Sbjct: 233 IKANVFVQL-----PRL------------QKLYL-------DRNLIAAVAPGAFLGLKAL 268
Query: 277 ESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGL-PSGMKGLNLLKKLVLSVNHFDQ 335
L+L +R + + TF L+ L L+ + L P K L+ L++L L N Q
Sbjct: 269 RWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQ 328
Query: 336 LCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNL 395
L + S E LG L+ L L HN ++ + L
Sbjct: 329 LAERS-------------------------FEGLGQLEVLTLDHNQLQEVKAGAFL--GL 361
Query: 396 SHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYC 455
+++ +NLS N L Q F+ +L L L + L P + F L L+ L L
Sbjct: 362 TNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHT-FTGLSGLRRLFLKDN 420
Query: 456 FLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQA 515
L + L GL L L+L N T L Q +G LE L+LS L + A
Sbjct: 421 GLVGIEEQSLWGLAELLELDLTSNQL---THLPHRLFQGLGKLEYLLLSRNRLAELPADA 477
Query: 516 FHSLGKMSHVDLSHNSLTCDSIDSLSHLKGI-YLNLAANSINIISPRLLPILSQQSTINL 574
L + +D+SHN L L+ L + YL+L NS+ +P+ P L + + L
Sbjct: 478 LGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ-PPGLER---LWL 533
Query: 575 SHNPLDCTCSNIHFLTWYKENLHKL--------EGSE---------ETTCANPPSLRGVK 617
NP DC C + +N + EG + TCA+PP + G+
Sbjct: 534 EGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLD 593
Query: 618 LSDV 621
L D+
Sbjct: 594 LRDL 597
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 92.4 bits (228), Expect = 1e-18
Identities = 117/456 (25%), Positives = 180/456 (39%), Gaps = 75/456 (16%)
Query: 28 CIEKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFN------------------------ 63
C E + +C LGLS +P L T +L+ S N
Sbjct: 41 CQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGN 100
Query: 64 FLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNG 123
L I + FS L +L L L Q+ I + L +L L N + + E S G
Sbjct: 101 HLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEG 160
Query: 124 PKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLK---VLDF 180
SL+HL+L ++ + ++NL L+++ L N IS I D+ +NL VL
Sbjct: 161 LSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHI---PDYAFQNLTSLVVLHL 217
Query: 181 QNNAIHYISREDMRSLEQAINLSLNFNGNN---VKGIELGAFDSTIFQSLNFGGTPNLSV 237
NN I ++ L L LN+N V LG F + N P +
Sbjct: 218 HNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAF 277
Query: 238 IFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLN--LQEHRFSDISSTTFQ 295
+ N L + F D + + + + L ++ SLN + F D+ T
Sbjct: 278 MGNPLLQTI-------HFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGT--- 327
Query: 296 CFTQLQELDLTATHLKGLPSGM-KGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRG 354
T L+ L LT ++ LPSGM + L L+ L LS N ++L + L + ++
Sbjct: 328 --TSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQ--KLEEIGLQH 383
Query: 355 NVKKLHLGVGCLEKLGNLQTLDLSHN-------------------DIEASDCCSLQLKNL 395
N + +G +L +LQ LDLS N D+ + +L L L
Sbjct: 384 N-RIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGL 442
Query: 396 SHLQTLNLSHNEPLGLQSQAFKE--CPQLELLDLAF 429
L L L N L SQAF + P+L +L++ +
Sbjct: 443 GGLMHLKLKGNLAL---SQAFSKDSFPKLRILEVPY 475
Score = 69.3 bits (168), Expect = 1e-11
Identities = 78/315 (24%), Positives = 131/315 (41%), Gaps = 49/315 (15%)
Query: 275 SVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLP-SGMKGLNLLKKLVLSVNHF 333
S++SL L + S + +F+ + L+ L L L +P + L L+ + L++N
Sbjct: 139 SLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRI 198
Query: 334 DQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLK 393
+ + N SL L++ N + HLG E L NL+TLDL++N ++ + ++
Sbjct: 199 SHIPDYAFQNLTSLVVLHLHNN-RIQHLGTHSFEGLHNLETLDLNYNKLQEFP---VAIR 254
Query: 394 NLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDL-----------AFT---RLHINAPQS 439
L LQ L +N + +AF P L+ + AF +LH +
Sbjct: 255 TLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 314
Query: 440 PFQNLHF--------LQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQD-GTITKTN 490
F L++L LT + + LP LR L L N ++ ++ +
Sbjct: 315 AMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQ 374
Query: 491 LLQTVG------------------SLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSL 532
L+ +G SL+ L LS + SI +AF +L + +DL+ N L
Sbjct: 375 KLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL 434
Query: 533 T---CDSIDSLSHLK 544
T + L HLK
Sbjct: 435 TTLPLAGLGGLMHLK 449
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 91.7 bits (226), Expect = 2e-18
Identities = 147/687 (21%), Positives = 251/687 (36%), Gaps = 110/687 (16%)
Query: 33 ANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWI 92
+ T +C L L +P +P TE L+ + N + I F+ L +L L L +I+ I
Sbjct: 35 SGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTI 94
Query: 93 HEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLE 152
FQ +L L L N L E G L L L + I + +++
Sbjct: 95 ERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIK 154
Query: 153 SLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINL-SLNFNGNNV 211
+L L N IS I+ R+L+VL N + I+R + S L + + NN+
Sbjct: 155 NLQLDYNQISCIEDGAFRALRDLEVLTLNN---NNITRLSVASFNHMPKLRTFRLHSNNL 211
Query: 212 K------------------GIELGAFDSTIFQSLNFGGTPNLSVIFNGLQN--STTQSLW 251
G+ + + N + +G Q+ + + S+
Sbjct: 212 YCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVL 271
Query: 252 LGTFEDIDDEDISSAMLKGLCEM------SVESLNLQEHRFSDISSTTFQCFTQLQELDL 305
+I KGL E+ ++ + L+++ I F + +L+ +DL
Sbjct: 272 HCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDL 331
Query: 306 TATHLKGL-PSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGN--------- 355
+ + L P +GL L LVL N +L + SL L + N
Sbjct: 332 SNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDA 391
Query: 356 VKKLH--------------LGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTL 401
+ LH + G L +QT+ L+ N DC L + H +
Sbjct: 392 FQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPF-ICDCHLKWLADYLHTNPI 450
Query: 402 NLSH----------NEPLG-LQSQAFK---------------------------ECPQL- 422
S N+ +G ++S+ F+ CP+
Sbjct: 451 ETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKC 510
Query: 423 ----ELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKG 478
+D + +L+ P+ Q L++ N + L+ + + LP LR +N
Sbjct: 511 RCEGTTVDCSNQKLN-KIPEHIPQYTAELRLNNNEFTVLEATG--IFKKLPQLRKINFSN 567
Query: 479 NHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSID 538
N D + + + ++L+S L ++ + F L + + L N +TC D
Sbjct: 568 NKITD---IEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGND 624
Query: 539 SLSHLKGI-YLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLH 597
S L + L+L N I ++P L ST+NL NP +C C +L W E L
Sbjct: 625 SFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNC----YLAWLGEWLR 680
Query: 598 KLE-GSEETTCANPPSLRGVKLSDVKL 623
K + C P L+ + + DV +
Sbjct: 681 KKRIVTGNPRCQKPYFLKEIPIQDVAI 707
Score = 80.5 bits (197), Expect = 5e-15
Identities = 141/630 (22%), Positives = 245/630 (38%), Gaps = 72/630 (11%)
Query: 33 ANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWI 92
+N +C GL+EIP LP T + N + I FS L +DL+ QI+ +
Sbjct: 280 SNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISEL 339
Query: 93 HEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLE 152
D FQ L++LVL GN + + ++ G SL+ L L I+ L +L NL
Sbjct: 340 APDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLN 399
Query: 153 SLYLGSNHISSIKFPKDFPARNLKVLDFQNNAI----------HYISREDMRSLEQAINL 202
L L N + +I P R ++ + N Y+ + +
Sbjct: 400 LLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTS 459
Query: 203 SLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNG----LQNSTTQSLWLGTFEDI 258
+ I+ F + + GT + +G + GT D
Sbjct: 460 PRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDC 519
Query: 259 DDEDISSAMLKGLCEMSVESLNLQEHRFSDISST-TFQCFTQLQELDLTATHLKGLPSG- 316
++ ++ + + + + + E L L + F+ + +T F+ QL++++ + + + G
Sbjct: 520 SNQKLNK-IPEHIPQYTAE-LRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGA 577
Query: 317 MKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGN---------------VKKLHL 361
+G + + +++L+ N + + SL L +R N V+ L L
Sbjct: 578 FEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSL 637
Query: 362 --------GVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSH-LQTLNLSHNEPLGLQ 412
G + L +L TL+L N C+ L L L+ + P +
Sbjct: 638 YDNQITTVAPGAFDTLHSLSTLNLLANPFN----CNCYLAWLGEWLRKKRIVTGNPRCQK 693
Query: 413 SQAFKECPQLELLDLAFTRLHINAPQ--SPFQNLHFLQVLNLTYC-FLDTSNQHLLAGLP 469
KE P ++ FT N SP T C LDT + GL
Sbjct: 694 PYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCP-------TECTCLDTVVRCSNKGLK 746
Query: 470 VL--------RHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGK 521
VL L L GN F T+ L L ++ LS+ + ++ Q+F ++ +
Sbjct: 747 VLPKGIPRDVTELYLDGNQF---TLVPKE-LSNYKHLTLIDLSNNRISTLSNQSFSNMTQ 802
Query: 522 MSHVDLSHNSLTCDSIDSLSHLKGI-YLNLAANSINIISPRLLPILSQQSTINLSHNPLD 580
+ + LS+N L C + LK + L+L N I+++ LS S + + NPL
Sbjct: 803 LLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLY 862
Query: 581 CTCSNIHFLTWYKENLHKLEGSEETTCANP 610
C C N+ +L+ + ++ +K G CA P
Sbjct: 863 CDC-NMQWLSDWVKSEYKEPGI--ARCAGP 889
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 91.3 bits (225), Expect = 3e-18
Identities = 114/450 (25%), Positives = 184/450 (40%), Gaps = 71/450 (15%)
Query: 32 EANKTYNCENLGLSEIPDTLPNTTEFLEFSFNF------------------------LPT 67
+ ++ +C GL+ +P+ L T+ L+ S N L
Sbjct: 36 DGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSF 95
Query: 68 IHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSL 127
IH + S L L L L Q+ + + + L +L L N + + E S G L
Sbjct: 96 IHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQL 155
Query: 128 KHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLK---VLDFQNNA 184
+HL+L ++ + P+ NL L++L L N ISSI DF NL VL NN
Sbjct: 156 RHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSI---PDFAFTNLSSLVVLHLHNNK 212
Query: 185 IHYISREDMRSLEQAINLSLNFNG-----NNVKGI----ELGAFDSTI--FQSLNFGGTP 233
I +S+ L+ L LN+N +K + ELG ++I F G P
Sbjct: 213 IRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNP 272
Query: 234 NLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLC----------EMSVESLNLQE 283
L I L ++ + F ++ D+ S +++G + +ESL L
Sbjct: 273 LLRTIH--LYDNPLSFVGNSAFHNL--SDLHSLVIRGASMVQQFPNLTGTVHLESLTLTG 328
Query: 284 HRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAAN 343
+ S I + Q L+ LDL+ +++ LPS G + L+++ L N Q+ QI
Sbjct: 329 TKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS-FNGCHALEEISLQRN---QIYQIKEGT 384
Query: 344 FPSLTHLYI----RGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQ 399
F L L I R + ++H LG + LD+S N++ S + L+ L
Sbjct: 385 FQGLISLRILDLSRNLIHEIH--SRAFATLGPITNLDVSFNEL-----TSFPTEGLNGLN 437
Query: 400 TLNLSHNEPLGLQSQAFKECPQLELLDLAF 429
L L N L ++ A K+ L L + +
Sbjct: 438 QLKLVGNFKL-KEALAAKDFVNLRSLSVPY 466
Score = 68.6 bits (166), Expect = 2e-11
Identities = 97/402 (24%), Positives = 166/402 (41%), Gaps = 57/402 (14%)
Query: 191 EDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIF-QSLNFGGTPNLSVIFNGLQNSTTQS 249
E + + QA+++S+N N+ + AF + F + L G +LS I + S +
Sbjct: 53 EGLSAFTQALDISMN----NITQLPEDAFKNFPFLEELQLAGN-DLSFI-HPKALSGLKE 106
Query: 250 LWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATH 309
L + T ++ + + S ++GL +++SL L + + + +F+ QL+ L L
Sbjct: 107 LKVLTLQNNQLKTVPSEAIRGLS--ALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNS 164
Query: 310 LKGLP-SGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEK 368
L +P + L L+ L L++N + + N SL L++ N K L C +
Sbjct: 165 LTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNN-KIRSLSQHCFDG 223
Query: 369 LGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLA 428
L NL+TLDL++N++ +K L L+ L N + AF P L + L
Sbjct: 224 LDNLETLDLNYNNLGEFPQA---IKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLY 280
Query: 429 FTRLHINAPQSPFQNLH-----------------------FLQVLNLTYCFLDTSNQHLL 465
L S F NL L+ L LT + + +L
Sbjct: 281 DNPLSF-VGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLC 339
Query: 466 AGLPVLRHLNLKGNHFQDGTI-------------------TKTNLLQTVGSLEVLILSSC 506
+LR L+L N+ +D K Q + SL +L LS
Sbjct: 340 QEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRN 399
Query: 507 GLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYL 548
+ I +AF +LG ++++D+S N LT + L+ L + L
Sbjct: 400 LIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKL 441
>gi|7706093 toll-like receptor 7 [Homo sapiens]
Length = 1049
Score = 89.0 bits (219), Expect = 1e-17
Identities = 170/736 (23%), Positives = 290/736 (39%), Gaps = 148/736 (20%)
Query: 44 LSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTR-------CQINW-IHED 95
L EIP LP + + L N + +I + L N+ L L + C +++ I +D
Sbjct: 139 LLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKD 198
Query: 96 TFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLY 155
F + +L L L N + + P +L L+L I+ ++ +NL L+ L
Sbjct: 199 AFLNLTKLKVLSLKDNNVTAVPTVL---PSTLTELYLYNNMIAKIQEDDFNNLNQLQILD 255
Query: 156 LGSN---------------HISSIKFPKD-FPA-RNLKVLDFQNNAIHYISREDMRSLE- 197
L N + S ++ P + F A LKVL +N++ ++ +++
Sbjct: 256 LSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINK 315
Query: 198 -QAINLSLNFNGNNVKGIELGAFDSTIFQ---SLNFG-----GTPNLSVIFNGLQNSTTQ 248
Q ++LS NF + + F ++ Q S NF + NLS F+ L++
Sbjct: 316 LQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKIL 375
Query: 249 SLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTAT 308
+ F+++ ++S L L + V L + +++S F+ F +L+ +DL+
Sbjct: 376 RIRGYVFKELKSFNLSP--LHNLQNLEVLDLGTNFIKIANLSM--FKQFKRLKVIDLSVN 431
Query: 309 HLKGLPSGMKG-LNLLKKLVLSVNHFDQ--LCQISAANFPSLTHLYIRGNVKKLHLGVG- 364
+ PSG + SV ++ L Q+ + N + + V
Sbjct: 432 KIS--PSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNE 489
Query: 365 CLEKLGNLQTLDLSHNDI---EASDCCSLQLKNLSHLQTLNLSHNE-PLGLQSQAFKECP 420
K G QTLDLS N I ++SD ++LS L+ LNLS N L F+
Sbjct: 490 SCYKYG--QTLDLSKNSIFFVKSSD-----FQHLSFLKCLNLSGNLISQTLNGSEFQPLA 542
Query: 421 QLELLDLAFTRLHINAPQSPFQNLHFLQVLNL------------TYCFLDTSNQHLLAGL 468
+L LD + RL + + F+ LH L+VL++ T+ T N +L L
Sbjct: 543 ELRYLDFSNNRLDL-LHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKL 601
Query: 469 PV-----------------LRHLNLKGNH----FQDGTITKTNLLQTVGSLEVLILSSC- 506
+ LR L +GNH +++G L + + LE L +S
Sbjct: 602 MMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNS 661
Query: 507 ------------------------GLLSIDQQAFHSLGKMSHVDLSHNSLTC--DSIDSL 540
GL S + L + +DLSHN LT + + +
Sbjct: 662 LSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNC 721
Query: 541 SH-LKGI----------------------YLNLAANSINIISPRLLP--ILSQQSTINLS 575
S LK + YL+L++N I +I P +L+ + L
Sbjct: 722 SRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLH 781
Query: 576 HNPLDCTCSNIHFLTWYKENLHKLEG-SEETTCANPPSLRGVKLSDVKLSCGITAIGIFF 634
HN CTC + F+ W + + + TC P + +G S + L + +
Sbjct: 782 HNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKG--QSVISLDLYTCELDLTN 839
Query: 635 LIVFLLLLAILLFFAV 650
LI+F L +++ LF V
Sbjct: 840 LILFSLSISVSLFLMV 855
Score = 72.4 bits (176), Expect = 1e-12
Identities = 146/577 (25%), Positives = 224/577 (38%), Gaps = 95/577 (16%)
Query: 38 NCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQIN------- 90
+C + L+EIP +P T L + N +P I +F RL +L +D RC
Sbjct: 50 DCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDF-RCNCVPIPLGSK 108
Query: 91 --------WIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEF 142
I +F L +L L GN L+ E P SL+ L L I ++
Sbjct: 109 NNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLL---EIPQGLPPSLQLLSLEANNIFSIRK 165
Query: 143 IPVHNLENLESLYLGSN-------HIS-SIKFPKDFPARNLKVLDFQNNAIHYISREDMR 194
+ L N+E LYLG N ++S SI+ LKVL ++N + +
Sbjct: 166 ENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPS 225
Query: 195 SLEQAINLSLNFNGNNVKGIELGAFDS-TIFQSLNFGGTPNLSVIFNG------LQNSTT 247
+L + L N + I+ F++ Q L+ G N +N +N++
Sbjct: 226 TLTE-----LYLYNNMIAKIQEDDFNNLNQLQILDLSG--NCPRCYNAPFPCAPCKNNSP 278
Query: 248 QSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTA 307
+ + F+ L E+ V L L + + F+ +LQELDL+
Sbjct: 279 LQIPVNAFD-------------ALTELKV--LRLHSNSLQHVPPRWFKNINKLQELDLSQ 323
Query: 308 THLKGLPSGMKGLNLLKKLV---LSVNHFDQLCQISA------ANFPSLTHLYIRGNVKK 358
L K L+ L L+ LS N Q+ + S ++ SL L IRG V K
Sbjct: 324 NFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFK 383
Query: 359 --LHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNE--------P 408
+ L L NL+ LDL N I+ ++ K L+ ++LS N+
Sbjct: 384 ELKSFNLSPLHNLQNLEVLDLGTNFIKIANLS--MFKQFKRLKVIDLSVNKISPSGDSSE 441
Query: 409 LGLQSQAFKECPQLE---LLDLAFTRLHINAPQSPFQN--LHFLQVLNLTYCF---LDTS 460
+G S A E L L + R A F+N F+ V Y + LD S
Sbjct: 442 VGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLS 501
Query: 461 NQHL-------LAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQ 513
+ L L+ LNL GN T+ + Q + L L S+ L +
Sbjct: 502 KNSIFFVKSSDFQHLSFLKCLNLSGNLISQ-TLNGSE-FQPLAELRYLDFSNNRLDLLHS 559
Query: 514 QAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNL 550
AF L K+ +D+S NS S + ++H+ NL
Sbjct: 560 TAFEELHKLEVLDISSNSHYFQS-EGITHMLNFTKNL 595
Score = 43.9 bits (102), Expect = 5e-04
Identities = 76/319 (23%), Positives = 127/319 (39%), Gaps = 63/319 (19%)
Query: 303 LDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLG 362
+D T HL +P G+ L L++NH IS A+F L HL ++
Sbjct: 49 VDCTDKHLTEIPGGIP--TNTTNLTLTINHIPD---ISPASFHRLDHLV------EIDFR 97
Query: 363 VGCLE-KLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNE----PLGLQSQAFK 417
C+ LG+ + + I+ L++L++L L N+ P GL
Sbjct: 98 CNCVPIPLGSKNNMCIKRLQIKPRS-----FSGLTYLKSLYLDGNQLLEIPQGLP----- 147
Query: 418 ECPQLELLDLAFTRLHINAPQS--PFQNLHFLQVLNLTY----CFLDTS-NQHLLAGLPV 470
P L+LL L + ++ N+ L + Y C++ S + L
Sbjct: 148 --PSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTK 205
Query: 471 LRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHN 530
L+ L+LK N+ T T L T L L L + + I + F++L ++ +DLS N
Sbjct: 206 LKVLSLKDNNV---TAVPTVLPST---LTELYLYNNMIAKIQEDDFNNLNQLQILDLSGN 259
Query: 531 SLTC--------------------DSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQS 570
C ++ D+L+ LK L L +NS+ + PR +++
Sbjct: 260 CPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELK--VLRLHSNSLQHVPPRWFKNINKLQ 317
Query: 571 TINLSHNPLDCTCSNIHFL 589
++LS N L + FL
Sbjct: 318 ELDLSQNFLAKEIGDAKFL 336
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 88.6 bits (218), Expect = 2e-17
Identities = 110/404 (27%), Positives = 175/404 (43%), Gaps = 35/404 (8%)
Query: 38 NCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTF 97
+C L+ +P+ LP+ L+ S N L I + S L +L + L ++ I +
Sbjct: 59 DCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLG 117
Query: 98 QSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLG 157
++ L L GN ++ + L +SL+ L L IS L+ L+ LYL
Sbjct: 118 PVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ--TAFPALQLKYLYLN 175
Query: 158 SNHISSIKFPKDFP--ARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIE 215
SN ++S++ P F A L VL N I I + M L Q +L L N N +K +
Sbjct: 176 SNRVTSME-PGYFDNLANTLLVLKLNRNRISAIPPK-MFKLPQLQHLEL--NRNKIKNV- 230
Query: 216 LGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLW-LGTFEDIDDE-----DISSAMLK 269
D FQ L G +L + NG+ + W L E + + +I+ L
Sbjct: 231 ----DGLTFQGL--GALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLY 284
Query: 270 GLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGL-PSGMKGLNLLKKLVL 328
GL + ++ L+L ++ + IS ++ +L ELDLT HL L S GL+LL L +
Sbjct: 285 GL--LMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHI 342
Query: 329 SVNHFDQLCQISAANFPSLTHLYIRGN-----VKKLHLGVGCLEKLGNLQTLDLSHNDIE 383
N + + SL L ++ N ++ ++ G L L+ L L N I
Sbjct: 343 GNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMN---GAFSGLDKLRRLILQGNRIR 399
Query: 384 ASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDL 427
+ L L+ L+LS N + LQ AF + +L+ L L
Sbjct: 400 S--ITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHL 441
Score = 77.8 bits (190), Expect = 3e-14
Identities = 111/494 (22%), Positives = 188/494 (38%), Gaps = 88/494 (17%)
Query: 124 PKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFP-ARNLKVLDFQN 182
P + L L +S ++ + +L++L + L +N + +I P P + N+ +L
Sbjct: 73 PSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI--PNLGPVSANITLLSLAG 130
Query: 183 NAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGL 242
N I I E ++ + L L+ NN+ ++ T F P L + + L
Sbjct: 131 NRIVEILPEHLKEFQSLETLDLS--SNNISELQ------TAF--------PALQLKYLYL 174
Query: 243 QNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQE 302
++ S+ G F+++ + ++ L L +R S I F+ QLQ
Sbjct: 175 NSNRVTSMEPGYFDNLAN--------------TLLVLKLNRNRISAIPPKMFK-LPQLQH 219
Query: 303 LDLTATHLKGLPS-GMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHL 361
L+L +K + +GL LK L + N +L
Sbjct: 220 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD----------------------- 256
Query: 362 GVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQ 421
G L N++ L L HN++ ++ L L LQ L+LS N + A++ C +
Sbjct: 257 --GAFWGLSNMEILQLDHNNL--TEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQK 312
Query: 422 LELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHF 481
L LDL F L S F L L L++ + GL L+ L+LK N
Sbjct: 313 LSELDLTFNHLS-RLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEI 371
Query: 482 QDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLS 541
+ L LIL + SI ++AF L + H+DLS N++ ++ S
Sbjct: 372 SWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFS 431
Query: 542 HLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEG 601
+K + ++L+ + L C C W EN +
Sbjct: 432 QMKKL-----------------------QQLHLNTSSLLCDCQLKWLPQWVAEN--NFQS 466
Query: 602 SEETTCANPPSLRG 615
+CA+P L+G
Sbjct: 467 FVNASCAHPQLLKG 480
Score = 43.1 bits (100), Expect = 8e-04
Identities = 58/257 (22%), Positives = 94/257 (36%), Gaps = 30/257 (11%)
Query: 56 EFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIF 115
+ LE + N + + TF L L L + R + + + F + L L N L
Sbjct: 218 QHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE 277
Query: 116 MAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNL 175
+ + L G L+ L L Q I+ + + L L L NH+S + L
Sbjct: 278 ITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLL 337
Query: 176 KVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLN--FGGTP 233
L NN + YI+ R L L L N E+ S + +N F G
Sbjct: 338 NTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN-------EI----SWTIEDMNGAFSGLD 386
Query: 234 NLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTT 293
L + LQ + +S+ F +D ++E L+L ++ +
Sbjct: 387 KLRRLI--LQGNRIRSITKKAFTGLD---------------ALEHLDLSDNAIMSLQGNA 429
Query: 294 FQCFTQLQELDLTATHL 310
F +LQ+L L + L
Sbjct: 430 FSQMKKLQQLHLNTSSL 446
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 88.2 bits (217), Expect = 2e-17
Identities = 112/419 (26%), Positives = 173/419 (41%), Gaps = 54/419 (12%)
Query: 44 LSEIPDTLPNTTEFLE---FSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSH 100
L+E+ L + FLE S N L I + FS L +L L L Q+ I +
Sbjct: 26 LTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWEL 85
Query: 101 HQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNH 160
L +L L N + + E S G SL+HL+L ++ + ++NL L+++ L N
Sbjct: 86 PSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNR 145
Query: 161 ISSIKFPKDFPARNLK---VLDFQNNAIHYISREDMRSLEQAINLSLNFNGNN---VKGI 214
IS I D+ +NL VL NN I ++ L L LN+N V
Sbjct: 146 ISHI---PDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIR 202
Query: 215 ELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEM 274
LG F + N P + + N L + F D + + + + L ++
Sbjct: 203 TLGRLQELGFHNNNIKAIPEKAFMGNPLLQTI-------HFYDNPIQFVGRSAFQYLPKL 255
Query: 275 SVESLN--LQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGM-KGLNLLKKLVLSVN 331
SLN + F D+ T T L+ L LT ++ LPSGM + L L+ L LS N
Sbjct: 256 HTLSLNGAMDIQEFPDLKGT-----TSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHN 310
Query: 332 HFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHN----------- 380
++L + L + ++ N + +G +L +LQ LDLS N
Sbjct: 311 QIEELPSLHRCQ--KLEEIGLQHN-RIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFS 367
Query: 381 --------DIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKE--CPQLELLDLAF 429
D+ + +L L L L L L N L SQAF + P+L +L++ +
Sbjct: 368 TLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLAL---SQAFSKDSFPKLRILEVPY 423
Score = 76.3 bits (186), Expect = 9e-14
Identities = 108/433 (24%), Positives = 170/433 (39%), Gaps = 82/433 (18%)
Query: 78 NLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGI 137
+L+ +LT Q H F L L L+GN L + + +G SLK L L +
Sbjct: 20 DLSMNNLTELQPGLFHHLRF-----LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL 74
Query: 138 SNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLE 197
+ + L +L+SL L +N IS + +L+ L +NA+ I + +L
Sbjct: 75 GGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLP 134
Query: 198 --QAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTF 255
QA+ L+LN + FQ+L S++ L N+ Q L +F
Sbjct: 135 ALQAMTLALN---------RISHIPDYAFQNLT-------SLVVLHLHNNRIQHLGTHSF 178
Query: 256 EDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPS 315
E + ++E+L+L ++ + + +LQEL ++K +P
Sbjct: 179 EGLH---------------NLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPE 222
Query: 316 ----------------------GMKGLNLLKKL-------VLSVNHFDQLCQISAANFPS 346
G L KL + + F L ++ +
Sbjct: 223 KAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILT 282
Query: 347 LTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHN 406
LT IR L G ++L L+ L+LSHN IE L L+ + L HN
Sbjct: 283 LTRAGIR------LLPSGMCQQLPRLRVLELSHNQIEELP----SLHRCQKLEEIGLQHN 332
Query: 407 EPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLA 466
+ + F + L+ LDL++ + P++ F LH L L+LT L T LA
Sbjct: 333 RIWEIGADTFSQLSSLQALDLSWNAIRSIHPEA-FSTLHSLVKLDLTDNQLTTLP---LA 388
Query: 467 GLPVLRHLNLKGN 479
GL L HL LKGN
Sbjct: 389 GLGGLMHLKLKGN 401
Score = 69.3 bits (168), Expect = 1e-11
Identities = 78/315 (24%), Positives = 131/315 (41%), Gaps = 49/315 (15%)
Query: 275 SVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLP-SGMKGLNLLKKLVLSVNHF 333
S++SL L + S + +F+ + L+ L L L +P + L L+ + L++N
Sbjct: 87 SLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRI 146
Query: 334 DQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLK 393
+ + N SL L++ N + HLG E L NL+TLDL++N ++ + ++
Sbjct: 147 SHIPDYAFQNLTSLVVLHLHNN-RIQHLGTHSFEGLHNLETLDLNYNKLQEFP---VAIR 202
Query: 394 NLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDL-----------AFT---RLHINAPQS 439
L LQ L +N + +AF P L+ + AF +LH +
Sbjct: 203 TLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 262
Query: 440 PFQNLHF--------LQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQD-GTITKTN 490
F L++L LT + + LP LR L L N ++ ++ +
Sbjct: 263 AMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQ 322
Query: 491 LLQTVG------------------SLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSL 532
L+ +G SL+ L LS + SI +AF +L + +DL+ N L
Sbjct: 323 KLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL 382
Query: 533 T---CDSIDSLSHLK 544
T + L HLK
Sbjct: 383 TTLPLAGLGGLMHLK 397
Score = 57.0 bits (136), Expect = 5e-08
Identities = 89/384 (23%), Positives = 142/384 (36%), Gaps = 85/384 (22%)
Query: 271 LCEMSV--ESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLP-SGMKGLNLLKKLV 327
+C++S+ + +L + +++ F L+EL L+ HL +P GL LK L+
Sbjct: 9 VCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILM 68
Query: 328 LSVNHFDQLCQISAANFPSLTHLYIRGNVKKL-----------------------HLGVG 364
L N + + PSL L + N+ L + V
Sbjct: 69 LQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR 128
Query: 365 CLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLEL 424
L L LQ + L+ N I S +NL+ L L+L +N L + +F+ LE
Sbjct: 129 ALNNLPALQAMTLALNRI--SHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLET 186
Query: 425 LDLAFTRL------------------HIN----APQSPFQNLHFLQVLNLTYCFLDTSNQ 462
LDL + +L H N P+ F LQ ++ + +
Sbjct: 187 LDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGR 246
Query: 463 HLLAGLPVLRHLNLKG----NHFQDGTITKTNLLQTVGSLEVLILSSCGL---------- 508
LP L L+L G F D L+ SLE+L L+ G+
Sbjct: 247 SAFQYLPKLHTLSLNGAMDIQEFPD--------LKGTTSLEILTLTRAGIRLLPSGMCQQ 298
Query: 509 --------LSIDQ----QAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIY-LNLAANSI 555
LS +Q + H K+ + L HN + D+ S L + L+L+ N+I
Sbjct: 299 LPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAI 358
Query: 556 NIISPRLLPILSQQSTINLSHNPL 579
I P L ++L+ N L
Sbjct: 359 RSIHPEAFSTLHSLVKLDLTDNQL 382
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 87.4 bits (215), Expect = 4e-17
Identities = 114/430 (26%), Positives = 165/430 (38%), Gaps = 39/430 (9%)
Query: 210 NVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDD--------- 260
N+ I L + QS +F G L + + +S ++ GTF D+
Sbjct: 51 NLTHILLFGMGRGVLQSQSFSGMTVLQRLM--ISDSHISAVAPGTFSDLIKLKTLRLSRN 108
Query: 261 --EDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGM- 317
+ A+L + + +E L L + I FQ LQEL L L LP+ +
Sbjct: 109 KITHLPGALLDKM--VLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLF 166
Query: 318 KGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDL 377
L LK L LS N+ L + L L + N + + L G L LG L L
Sbjct: 167 TNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSN-RLVSLDSGLLNSLGALTELQF 225
Query: 378 SHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAP 437
N I + L +L +L LS N L S F L LL L F P
Sbjct: 226 HRNHIRS--IAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTL-FENPLAELP 282
Query: 438 QSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKT------NL 491
F + LQ L L N+ L LP NL + T++
Sbjct: 283 GVLFGEMGGLQELWL--------NRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGA 334
Query: 492 LQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTC---DSIDSLSHLKGIYL 548
Q +G L+VL L S GL ++ LGK+ V L N L +LS L+ + L
Sbjct: 335 FQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQL 394
Query: 549 NLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCA 608
+ N + + + L + + + L HN C C FL W +++L + G E CA
Sbjct: 395 D--HNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCA 452
Query: 609 NPPSLRGVKL 618
P + G+ L
Sbjct: 453 GPGAHAGLPL 462
Score = 65.1 bits (157), Expect = 2e-10
Identities = 98/406 (24%), Positives = 159/406 (39%), Gaps = 41/406 (10%)
Query: 53 NTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNP 112
N T L F + +++FS + L L ++ I+ + TF +L TL L+ N
Sbjct: 51 NLTHILLFGMG-RGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNK 109
Query: 113 LIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPA 172
+ + L+ L+ LFL + ++ L NL+ L L N + +
Sbjct: 110 ITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNL 169
Query: 173 RNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGT 232
NLK+LD N + ++ + + + + L L+ N L + DS + SL G
Sbjct: 170 ENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSN-------RLVSLDSGLLNSL--GAL 220
Query: 233 PNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKG-----------LCEMSVESLNL 281
L N + +S+ G F+ + ++SS L L ++ L L
Sbjct: 221 TELQFHRNHI-----RSIAPGAFDRL--PNLSSLTLSRNHLAFLPSALFLHSHNLTLLTL 273
Query: 282 QEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISA 341
E+ +++ F LQEL L T L+ LP+ NL + L V +L +
Sbjct: 274 FENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAA-AFRNLSRLRYLGVTLSPRLSALPQ 332
Query: 342 ANFPSLTHLYIRGNVKKLH------LGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNL 395
F L L V LH L G L LG L+ + L N + A +NL
Sbjct: 333 GAFQGLGEL----QVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALP--RALFRNL 386
Query: 396 SHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPF 441
S L+++ L HN+ L F P+L + L + PF
Sbjct: 387 SSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPF 432
Score = 55.1 bits (131), Expect = 2e-07
Identities = 76/325 (23%), Positives = 124/325 (38%), Gaps = 32/325 (9%)
Query: 35 KTYNCENLGLSEIPDTLPNTTEFLEFSF---NFLPTIHNRTFSRLMNLTFLDLTRCQINW 91
KT ++ +P L + LE F N L I F +L+NL L L + Q+++
Sbjct: 101 KTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDF 160
Query: 92 IHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENL 151
+ F + L L L+GN L + + L L+ L L + +L+ +++L L
Sbjct: 161 LPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGAL 220
Query: 152 ESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNV 211
L NHI SI NL L N + ++ +L + +N+
Sbjct: 221 TELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPS------------ALFLHSHNL 268
Query: 212 KGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGL 271
+ L + FG L Q LWL + + +A + L
Sbjct: 269 TLLTLFENPLAELPGVLFGEMGGL------------QELWLNRTQ---LRTLPAAAFRNL 313
Query: 272 CEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSG-MKGLNLLKKLVLSV 330
+ + L R S + FQ +LQ L L + L LP G ++GL L+++ L
Sbjct: 314 SRLRYLGVTLSP-RLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRR 372
Query: 331 NHFDQLCQISAANFPSLTHLYIRGN 355
N L + N SL + + N
Sbjct: 373 NRLRALPRALFRNLSSLESVQLDHN 397
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 86.7 bits (213), Expect = 6e-17
Identities = 146/673 (21%), Positives = 242/673 (35%), Gaps = 99/673 (14%)
Query: 38 NCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTF 97
+C LGL +P +P E L+ N + I F+ L NL L L Q++ I F
Sbjct: 46 DCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAF 105
Query: 98 QSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLG 157
Q QL L L N L + E L L L + I + + ++++L L
Sbjct: 106 QDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLD 165
Query: 158 SNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELG 217
+NHIS I+ R+L++L NN I I + + L L+ N + L
Sbjct: 166 NNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSN-HLYCDCHLA 224
Query: 218 AFDSTIFQSLNFGG-----TPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLC 272
+ Q G P FN + + + + +S C
Sbjct: 225 WLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPC 284
Query: 273 EMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSG-MKGLNLLKKLVLSVN 331
S N+ + R + + E+ L +K +P+G LK++ +S N
Sbjct: 285 TC---SNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKN 341
Query: 332 HFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEA------S 385
+ + SLT L + GN K + G + L +LQ L L+ N I
Sbjct: 342 QISDIAPDAFQGLKSLTSLVLYGN-KITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQ 400
Query: 386 DCCSLQLKN----------------LSHLQTLNLSHN--------------------EPL 409
D +L L + L +QTL+L+ N E
Sbjct: 401 DLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETS 460
Query: 410 GLQSQAFKECPQLELLDLAFTRLHINAPQ---SPFQNLHFLQVLNLTYC-----FLDTSN 461
G + + + + + + + + S F + F+ ++ C +D SN
Sbjct: 461 GARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSN 520
Query: 462 QHLLAGLPVLRHL-----NLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAF 516
Q L+ + HL +L+ N + + T + + + +L + LS+ + + + AF
Sbjct: 521 QKLVR---IPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAF 577
Query: 517 HSLGKMSHVDLSHNSLT------------------------CDSIDSLSHLKGI-YLNLA 551
+ + L+ N L C S D+ + L + L+L
Sbjct: 578 DGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLY 637
Query: 552 ANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLE-GSEETTCANP 610
N I I+P L STINL NP +C C L W + L K S C P
Sbjct: 638 DNRITTITPGAFTTLVSLSTINLLSNPFNCNC----HLAWLGKWLRKRRIVSGNPRCQKP 693
Query: 611 PSLRGVKLSDVKL 623
L+ + + DV +
Sbjct: 694 FFLKEIPIQDVAI 706
Score = 62.8 bits (151), Expect = 1e-09
Identities = 44/151 (29%), Positives = 71/151 (47%)
Query: 33 ANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWI 92
+N +C GL EIP LP + N + I F++ L +D+++ QI+ I
Sbjct: 287 SNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDI 346
Query: 93 HEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLE 152
D FQ L++LVL GN + +A+ +G SL+ L L I+ L +L+NL
Sbjct: 347 APDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLN 406
Query: 153 SLYLGSNHISSIKFPKDFPARNLKVLDFQNN 183
L L N + +I P ++++ L N
Sbjct: 407 LLSLYDNKLQTISKGLFAPLQSIQTLHLAQN 437
Score = 57.4 bits (137), Expect = 4e-08
Identities = 123/545 (22%), Positives = 210/545 (38%), Gaps = 50/545 (9%)
Query: 63 NFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLN 122
N + I F L++L L L +IN + +TFQ L+ L L N L +++
Sbjct: 365 NKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFA 424
Query: 123 GPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPAR--NLKVLDF 180
+S++ L L Q F+ +L+ L YL N I + P R N ++
Sbjct: 425 PLQSIQTLHLAQN-----PFVCDCHLKWLAD-YLQDNPIETSGARCSSPRRLANKRISQI 478
Query: 181 QNNAIHYISREDMRSLEQAINLSLNFNGNNVKGI---ELGAFDSTIFQSLNFGGTPNLSV 237
++ ED RS F+ + E + TI N L
Sbjct: 479 KSKKFRCSGSEDYRS---------RFSSECFMDLVCPEKCRCEGTIVDCSN----QKLVR 525
Query: 238 IFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEM--SVESLNLQEHRFSDISSTTFQ 295
I + L T ++D ++S G+ + ++ +NL ++ ++ F
Sbjct: 526 IPSHLPEYVTDLR-------LNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFD 578
Query: 296 CFTQLQELDLTATHLKGLPSGM-KGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRG 354
+QEL LT L+ + + +GL+ LK L+L N + + A S+ L +
Sbjct: 579 GAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYD 638
Query: 355 NVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSH-LQTLNLSHNEPLGLQS 413
N + + G L +L T++L N C+ L L L+ + P +
Sbjct: 639 N-RITTITPGAFTTLVSLSTINLLSNPFN----CNCHLAWLGKWLRKRRIVSGNPRCQKP 693
Query: 414 QAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLA---GLPV 470
KE P ++ FT N S + + + SN+ L A G+P
Sbjct: 694 FFLKEIPIQDVAIQDFT-CDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPK 752
Query: 471 -LRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSH 529
+ L L+GNH L + L ++ LS+ + + F ++ +S + LS+
Sbjct: 753 DVTELYLEGNHLT----AVPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSY 808
Query: 530 NSLTCDSIDSLSHLKGI-YLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHF 588
N L C + + + L+ + L L N I+ + L+ S + L NPL C CS
Sbjct: 809 NRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWL 868
Query: 589 LTWYK 593
W K
Sbjct: 869 SEWVK 873
Score = 56.6 bits (135), Expect = 7e-08
Identities = 43/144 (29%), Positives = 68/144 (47%), Gaps = 3/144 (2%)
Query: 16 AGCKVITSWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSR 75
+ C++ + C E C N GL +P +P L N L + R S
Sbjct: 717 SSCQLSPRCPEQCTCMET--VVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVP-RELSA 773
Query: 76 LMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQT 135
L +LT +DL+ I+ + TF + LSTL+L+ N L + + NG +SL+ L L
Sbjct: 774 LRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGN 833
Query: 136 GISNLEFIPVHNLENLESLYLGSN 159
IS++ ++L +L L LG+N
Sbjct: 834 DISSVPEGSFNDLTSLSHLALGTN 857
>gi|38348406 leucine rich repeat containing 33 [Homo sapiens]
Length = 692
Score = 84.0 bits (206), Expect = 4e-16
Identities = 145/571 (25%), Positives = 226/571 (39%), Gaps = 41/571 (7%)
Query: 38 NCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTF 97
+C L+ +P +LP L N L T+ N + L L L C + I F
Sbjct: 42 DCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAF 101
Query: 98 QSHHQLSTLVLTGNPLIFMAE---TSLNGPKSLKHLFLIQTGIS-NLEFIPVHNLENLES 153
Q L +LVL N L E +L+ L+ L L ++ ++ + + NL +L S
Sbjct: 102 QEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRS 161
Query: 154 LYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKG 213
+ L N I + L+ LD Q N I I L + +L+L FN N+
Sbjct: 162 VSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFN--NLPC 219
Query: 214 IELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCE 273
I F T + LN + +V+ L + L T + ++ + +L +
Sbjct: 220 IV--DFGLTRLRVLNV----SYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSK 273
Query: 274 MSVESL---NLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPS----GMKGLNLLKKL 326
+ L N+ +R +S+ + Q +D T++ + L L+ L
Sbjct: 274 LRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFL 333
Query: 327 VLSVNHFDQLCQISAANFPSLTHLYIRGN-VKKLHLGVGCLEKLGNLQTLDLSHNDIEAS 385
+S N F L PSL+HL + N + LH+ E G L LDLSHN +
Sbjct: 334 DMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREH--EPPGALTELDLSHNQLSEL 391
Query: 386 DCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHIN---------A 436
L L+ NLS N+ LG+ F + LD++ ++ +
Sbjct: 392 HLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVG 451
Query: 437 PQS--PFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNH-FQDGTITKTNLLQ 493
P S F+N+ L+ L+L C L G L +L+L N +G++ L
Sbjct: 452 PPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTS-LTYLDLSSNWGVLNGSLAP--LQD 508
Query: 494 TVGSLEVLILSSCGLLSIDQQA-FHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAA 552
L+VL L + GL S F G + +DLS N LT S L L+L
Sbjct: 509 VAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGS-LALETLDLRR 567
Query: 553 NSINIISPRLLPILSQQS--TINLSHNPLDC 581
NS+ + + + + TI LS NP DC
Sbjct: 568 NSLTALPQKAVSEQLSRGLRTIYLSQNPYDC 598
>gi|16751843 toll-like receptor 5 [Homo sapiens]
Length = 858
Score = 82.8 bits (203), Expect = 9e-16
Identities = 155/637 (24%), Positives = 241/637 (37%), Gaps = 115/637 (18%)
Query: 44 LSEIPDTLPNTTEFLEFSFNFLPT-------------------------IHNRTFSRLMN 78
L+++P L NTTE L SFN++ T I F L N
Sbjct: 38 LTQVPQVL-NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPN 96
Query: 79 LTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGIS 138
L LDL +I ++H D FQ L L L+ +
Sbjct: 97 LRILDLGSSKIYFLHPDAFQGLFHLFEL----------------------RLYFCGLSDA 134
Query: 139 NLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARN-LKVLDFQNNAIHYISREDMRSLE 197
L+ NL+ L L L N I S+ F N LK +DF +N I + ++ L+
Sbjct: 135 VLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQ 194
Query: 198 ----QAINLSLNFNGNNVK---GIELGAFDSTIFQSLNFGG-------TPNLSVIFNGLQ 243
+L+ N + V G + F + + + L+ G T N S N +
Sbjct: 195 GKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFS---NAIS 251
Query: 244 NSTTQSLWLG--------TFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQ 295
S SL L F +I D D ++ GL SV L+L ++S F+
Sbjct: 252 KSQAFSLILAHHIMGAGFGFHNIKDPDQNT--FAGLARSSVRHLDLSHGFVFSLNSRVFE 309
Query: 296 CFTQLQELDLTATHL-KGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRG 354
L+ L+L + K GL+ L+ L LS N +L + P + ++
Sbjct: 310 TLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYI---- 365
Query: 355 NVKKLHLGV---GCLEKLGNLQTLDLSHND------IEASDCCSLQLKNLSHLQTLNLSH 405
+++K H+ + + L LQTLDL N I + L L L +NL+
Sbjct: 366 DLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTA 425
Query: 406 NEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTY-CFLDTSNQHL 464
N + L +LE LD+ + L + LQ+L L F S
Sbjct: 426 N-LIHLSEN------RLENLDILYFLLRV----------PHLQILILNQNRFSSCSGDQT 468
Query: 465 LAGLPVLRHLNLKGNHFQDGTITKT--NLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKM 522
+ P L L L N Q T+ ++ + + L+VL L+ L S+ F L +
Sbjct: 469 PSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTAL 528
Query: 523 SHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCT 582
+ L+ N LT S + L I L+++ N + +P + L S ++++HN C
Sbjct: 529 RGLSLNSNRLTVLSHNDLPANLEI-LDISRNQLLAPNPDVFVSL---SVLDITHNKFICE 584
Query: 583 CSNIHFLTWYKENLHKLEG-SEETTCANPPSLRGVKL 618
C F+ W + G + C P S GV L
Sbjct: 585 CELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSL 621
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 82.8 bits (203), Expect = 9e-16
Identities = 85/327 (25%), Positives = 138/327 (42%), Gaps = 48/327 (14%)
Query: 296 CFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYI--- 352
C Q ++ +L+ +P G+ L L H +Q+ I +F L HL I
Sbjct: 53 CSNQFSKVICVRKNLREVPDGISTNTRLLNL-----HENQIQIIKVNSFKHLRHLEILQL 107
Query: 353 -RGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGL 411
R +++ + +G L NL TL+L N + + LS L+ L L +N +
Sbjct: 108 SRNHIRTIE--IGAFNGLANLNTLELFDNRLTTIPNGAFVY--LSKLKELWLRNNPIESI 163
Query: 412 QSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVL 471
S AF P L LDL + + F+ L L+ LNL C L L L L
Sbjct: 164 PSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKL 221
Query: 472 RHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNS 531
L+L GNH + + Q + L+ L + + I++ AF +L + ++L+HN+
Sbjct: 222 DELDLSGNHL---SAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNN 278
Query: 532 LTC---DSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHF 588
LT D L HL+ I+L+ HNP +C C +I +
Sbjct: 279 LTLLPHDLFTPLHHLERIHLH--------------------------HNPWNCNC-DILW 311
Query: 589 LTWYKENLHKLEGSEETTCANPPSLRG 615
L+W+ +++ + C PP+L+G
Sbjct: 312 LSWWIKDMAPSNTACCARCNTPPNLKG 338
Score = 47.0 bits (110), Expect = 6e-05
Identities = 64/240 (26%), Positives = 107/240 (44%), Gaps = 22/240 (9%)
Query: 174 NLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTP 233
N ++L+ N I I + L L L+ N+++ IE+GAF+ +
Sbjct: 77 NTRLLNLHENQIQIIKVNSFKHLRHLEILQLS--RNHIRTIEIGAFNGLANLNTLELFDN 134
Query: 234 NLSVIFNG--LQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQE-HRFSDIS 290
L+ I NG + S + LWL + E I S + S+ L+L E R S IS
Sbjct: 135 RLTTIPNGAFVYLSKLKELWL---RNNPIESIPSYAFNRI--PSLRRLDLGELKRLSYIS 189
Query: 291 STTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHL 350
F+ + L+ L+L +L+ +P+ + L L +L LS NH L I +F L HL
Sbjct: 190 EGAFEGLSNLRYLNLAMCNLREIPN-LTPLIKLDELDLSGNH---LSAIRPGSFQGLMHL 245
Query: 351 ----YIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHN 406
I+ ++ + + L +L ++L+HN++ L HL+ ++L HN
Sbjct: 246 QKLWMIQSQIQVIER--NAFDNLQSLVEINLAHNNLTLLP--HDLFTPLHHLERIHLHHN 301
Score = 45.1 bits (105), Expect = 2e-04
Identities = 57/231 (24%), Positives = 98/231 (42%), Gaps = 40/231 (17%)
Query: 279 LNLQEHRFSDISSTTFQCFTQLQELDLTATHLK----GLPSGMKGLNL------------ 322
LNL E++ I +F+ L+ L L+ H++ G +G+ LN
Sbjct: 81 LNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIP 140
Query: 323 ---------LKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKL-HLGVGCLEKLGNL 372
LK+L L N + + + PSL L + G +K+L ++ G E L NL
Sbjct: 141 NGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDL-GELKRLSYISEGAFEGLSNL 199
Query: 373 QTLDLSHNDIEASDCCSLQ----LKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLA 428
+ L+L+ C+L+ L L L L+LS N ++ +F+ L+ L +
Sbjct: 200 RYLNLA--------MCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMI 251
Query: 429 FTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGN 479
+++ + ++ F NL L +NL + L L L L ++L N
Sbjct: 252 QSQIQV-IERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
Score = 41.2 bits (95), Expect = 0.003
Identities = 33/119 (27%), Positives = 55/119 (46%), Gaps = 2/119 (1%)
Query: 65 LPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGP 124
L I F L NL +L+L C + I T +L L L+GN L + S G
Sbjct: 185 LSYISEGAFEGLSNLRYLNLAMCNLREIPNLT--PLIKLDELDLSGNHLSAIRPGSFQGL 242
Query: 125 KSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNN 183
L+ L++IQ+ I +E NL++L + L N+++ + P +L+ + +N
Sbjct: 243 MHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 81.3 bits (199), Expect = 3e-15
Identities = 88/344 (25%), Positives = 142/344 (41%), Gaps = 43/344 (12%)
Query: 315 SGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLY---IRGNVKKLHLGVGCLEKLGN 371
S + GL+ L L L ++ + + F L HLY + N K L G + L N
Sbjct: 78 SELTGLHSLVALYLDNSN---ILYVYPKAFVQLRHLYFLFLNNNFIK-RLDPGIFKGLLN 133
Query: 372 LQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTR 431
L+ L L +N + S +L +Q LNL N L S F L +LDL+
Sbjct: 134 LRNLYLQYNQV--SFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNN 191
Query: 432 LHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNL 491
+ + +S FQ+L L L L L + L LR L+L N + +
Sbjct: 192 I-LRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIE---AIQPFA 247
Query: 492 LQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIY---- 547
+ + +LE L+L + + ++ + F + + H+ LSHN L + D+ S LK +
Sbjct: 248 FKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKL 307
Query: 548 ----------------------LNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSN 585
LNL+ N++ + PR+L LS + + NP +C C
Sbjct: 308 DRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKL 367
Query: 586 IHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKLSCGITA 629
+ W + L C NPPS+RG L + ++ +T+
Sbjct: 368 LGLRDWLASSAITL----NIYCQNPPSMRGRALRYINITNCVTS 407
Score = 75.1 bits (183), Expect = 2e-13
Identities = 112/464 (24%), Positives = 190/464 (40%), Gaps = 77/464 (16%)
Query: 5 VSCFFWVVLFSA--GCKVITSWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEFSF 62
V+C+ ++L GC + Q+C ++ N C NLGLS IP P +T FL +
Sbjct: 17 VTCYLLLLLHKEILGCSSVC---QLCTGRQIN----CRNLGLSSIPKNFPESTVFLYLTG 69
Query: 63 NFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLN 122
N + I+ + L +L L L I +++ F L L L N + +
Sbjct: 70 NNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFK 129
Query: 123 GPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQN 182
G +L++L+L +S + ++L +++ L L N ++ + L++LD N
Sbjct: 130 GLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSN 189
Query: 183 NAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGL 242
N I IS + LE L L NN+ + AF+ + +SL LS+ N +
Sbjct: 190 NNILRISESGFQHLENLACLYL--GSNNLTKVPSNAFE--VLKSLR-----RLSLSHNPI 240
Query: 243 QNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQE 302
E I KGL ++E L L+ R +++
Sbjct: 241 ------------------EAIQPFAFKGLA--NLEYLLLKNSRIRNVTR----------- 269
Query: 303 LDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLG 362
G G+N LK L+LS N + L + + +L +L + N + + +
Sbjct: 270 ------------DGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRN-RIISID 316
Query: 363 VGCLEKLG-NLQTLDLSHNDIEASDCCSLQ-LKNLSHLQTLNLSHNEPLGLQSQAFKECP 420
E +G +L+ L+LS N++ A L+ L +L HLQ +++ P C
Sbjct: 317 NDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQ----ANSNPWEC------NCK 366
Query: 421 QLELLD-LAFTRLHIN--APQSPFQNLHFLQVLNLTYCFLDTSN 461
L L D LA + + +N P L+ +N+T C + N
Sbjct: 367 LLGLRDWLASSAITLNIYCQNPPSMRGRALRYINITNCVTSSIN 410
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 81.3 bits (199), Expect = 3e-15
Identities = 121/461 (26%), Positives = 172/461 (37%), Gaps = 87/461 (18%)
Query: 78 NLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGI 137
N L + I ++E F + L L + N L + + SL++L L +
Sbjct: 60 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 119
Query: 138 SNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLE 197
L L++LESL L SN + I+ NLK
Sbjct: 120 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLK--------------------- 158
Query: 198 QAINLSLNFNGNNVKGIELGAFDSTI-FQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFE 256
L +GN+++ I GAFD + LN G +NS T
Sbjct: 159 -----ELQLHGNHLEYIPDGAFDHLVGLTKLNLG------------KNSLTH-------- 193
Query: 257 DIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSG 316
IS + + L + V L L E+R +DI TF LQEL L + L G
Sbjct: 194 ------ISPRVFQHLGNLQV--LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPG 245
Query: 317 MKGLN-LLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTL 375
+ N L++L LS NH QL P L L + GN K L +G + NL+ L
Sbjct: 246 LFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLK-ELSLGIFGPMPNLREL 304
Query: 376 DLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHIN 435
L N I S NL LQ L LS N+ + AF +L L LH N
Sbjct: 305 WLYDNHI--SSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELS-----LHTN 357
Query: 436 APQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTV 495
A Q LD + +LA L++++L+ N + N+ V
Sbjct: 358 ALQD-----------------LDGNVFRMLAN---LQNISLQNNRLRQ---LPGNIFANV 394
Query: 496 GSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDS 536
L + L + L ++ F LGK+ + L N CDS
Sbjct: 395 NGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDS 435
Score = 77.8 bits (190), Expect = 3e-14
Identities = 120/512 (23%), Positives = 189/512 (36%), Gaps = 117/512 (22%)
Query: 161 ISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFD 220
I ++ P + A +L++L+ H + L + ++L N + I GAF
Sbjct: 50 IVAVPTPLPWNAMSLQILN-----THITELNESPFLNISALIALRIEKNELSRITPGAFR 104
Query: 221 STIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLN 280
N G LS L N+ Q L +G F+ +D S+ESL
Sbjct: 105 -------NLGSLRYLS-----LANNKLQVLPIGLFQGLD---------------SLESLL 137
Query: 281 LQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQIS 340
L ++ I F + L+EL L HL+ +P G FD L ++
Sbjct: 138 LSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGA---------------FDHLVGLT 182
Query: 341 AANFP--SLTHLYIR-----GNVKKLHL--------GVGCLEKLGNLQTLDLSHNDIEAS 385
N SLTH+ R GN++ L L +G + L NLQ L L N I
Sbjct: 183 KLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI--- 239
Query: 386 DCCSLQLKNLSH-LQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRL------------ 432
S L + +H LQ L LS+N L F + PQL L L L
Sbjct: 240 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 299
Query: 433 ----------HINA-PQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHF 481
HI++ P + F NL LQVL L+ + + GL LR L+L N
Sbjct: 300 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 359
Query: 482 QDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLS 541
QD +D F L + ++ L +N L + +
Sbjct: 360 QD---------------------------LDGNVFRMLANLQNISLQNNRLRQLPGNIFA 392
Query: 542 HLKGIY-LNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLE 600
++ G+ + L N + + + L + + L NP C + W N +L
Sbjct: 393 NVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLG 452
Query: 601 GSEETTCANPPSLRGVKLSDVKLSCGITAIGI 632
C +P ++RG L + ++ + ++ +
Sbjct: 453 TDTVPVCFSPANVRGQSLIIINVNVAVPSVHV 484
Score = 62.4 bits (150), Expect = 1e-09
Identities = 89/324 (27%), Positives = 128/324 (39%), Gaps = 55/324 (16%)
Query: 58 LEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMA 117
L+ N L I + F L+ LT L+L + + I FQ L L L N L +
Sbjct: 160 LQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIP 219
Query: 118 ETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKV 177
+ +G +L+ L L Q I L HN NL+ LYL +NHIS + P F
Sbjct: 220 MGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP-PSIF------- 271
Query: 178 LDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSV 237
L Q L+L GN++K + LG FG PNL
Sbjct: 272 ----------------MQLPQLNRLTL--FGNSLKELSLGI----------FGPMPNL-- 301
Query: 238 IFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCF 297
+ LWL D + + L ++ V L L ++ S IS F
Sbjct: 302 ----------RELWL---YDNHISSLPDNVFSNLRQLQV--LILSRNQISFISPGAFNGL 346
Query: 298 TQLQELDLTATHLKGLPSGM-KGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNV 356
T+L+EL L L+ L + + L L+ + L N QL AN L + ++ N
Sbjct: 347 TELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQ 406
Query: 357 KKLHLGVGCLEKLGNLQTLDLSHN 380
+ +L +G + LG L L L N
Sbjct: 407 LE-NLPLGIFDHLGKLCELRLYDN 429
Score = 59.3 bits (142), Expect = 1e-08
Identities = 96/416 (23%), Positives = 153/416 (36%), Gaps = 36/416 (8%)
Query: 39 CENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQ 98
C + +P LP L+ + ++ F + L L + + +++ I F+
Sbjct: 45 CTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFR 104
Query: 99 SHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGS 158
+ L L L N L + G SL+ L L + ++ NL+ L L
Sbjct: 105 NLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHG 164
Query: 159 NHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLS-LNFNGNNVKGIELG 217
NH+ I L L+ N++ +IS R + NL L N + I +G
Sbjct: 165 NHLEYIPDGAFDHLVGLTKLNLGKNSLTHIS---PRVFQHLGNLQVLRLYENRLTDIPMG 221
Query: 218 AFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVE 277
FD G NL + LQ + L G F + +++
Sbjct: 222 TFD----------GLVNLQEL--ALQQNQIGLLSPGLFHN---------------NHNLQ 254
Query: 278 SLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKG-LNLLKKLVLSVNHFDQL 336
L L + S + + F QL L L LK L G+ G + L++L L NH L
Sbjct: 255 RLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSL 314
Query: 337 CQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLS 396
+N L L + N + + G L L+ L L N ++ D + L+
Sbjct: 315 PDNVFSNLRQLQVLILSRN-QISFISPGAFNGLTELRELSLHTNALQ--DLDGNVFRMLA 371
Query: 397 HLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNL 452
+LQ ++L +N L F L + L +L N P F +L L L L
Sbjct: 372 NLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLE-NLPLGIFDHLGKLCELRL 426
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 81.3 bits (199), Expect = 3e-15
Identities = 121/461 (26%), Positives = 172/461 (37%), Gaps = 87/461 (18%)
Query: 78 NLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGI 137
N L + I ++E F + L L + N L + + SL++L L +
Sbjct: 54 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 113
Query: 138 SNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLE 197
L L++LESL L SN + I+ NLK
Sbjct: 114 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLK--------------------- 152
Query: 198 QAINLSLNFNGNNVKGIELGAFDSTI-FQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFE 256
L +GN+++ I GAFD + LN G +NS T
Sbjct: 153 -----ELQLHGNHLEYIPDGAFDHLVGLTKLNLG------------KNSLTH-------- 187
Query: 257 DIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSG 316
IS + + L + V L L E+R +DI TF LQEL L + L G
Sbjct: 188 ------ISPRVFQHLGNLQV--LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPG 239
Query: 317 MKGLN-LLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTL 375
+ N L++L LS NH QL P L L + GN K L +G + NL+ L
Sbjct: 240 LFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLK-ELSLGIFGPMPNLREL 298
Query: 376 DLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHIN 435
L N I S NL LQ L LS N+ + AF +L L LH N
Sbjct: 299 WLYDNHI--SSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELS-----LHTN 351
Query: 436 APQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTV 495
A Q LD + +LA L++++L+ N + N+ V
Sbjct: 352 ALQD-----------------LDGNVFRMLAN---LQNISLQNNRLRQ---LPGNIFANV 388
Query: 496 GSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDS 536
L + L + L ++ F LGK+ + L N CDS
Sbjct: 389 NGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDS 429
Score = 77.8 bits (190), Expect = 3e-14
Identities = 120/512 (23%), Positives = 189/512 (36%), Gaps = 117/512 (22%)
Query: 161 ISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFD 220
I ++ P + A +L++L+ H + L + ++L N + I GAF
Sbjct: 44 IVAVPTPLPWNAMSLQILN-----THITELNESPFLNISALIALRIEKNELSRITPGAFR 98
Query: 221 STIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLN 280
N G LS L N+ Q L +G F+ +D S+ESL
Sbjct: 99 -------NLGSLRYLS-----LANNKLQVLPIGLFQGLD---------------SLESLL 131
Query: 281 LQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQIS 340
L ++ I F + L+EL L HL+ +P G FD L ++
Sbjct: 132 LSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGA---------------FDHLVGLT 176
Query: 341 AANFP--SLTHLYIR-----GNVKKLHL--------GVGCLEKLGNLQTLDLSHNDIEAS 385
N SLTH+ R GN++ L L +G + L NLQ L L N I
Sbjct: 177 KLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI--- 233
Query: 386 DCCSLQLKNLSH-LQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRL------------ 432
S L + +H LQ L LS+N L F + PQL L L L
Sbjct: 234 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 293
Query: 433 ----------HINA-PQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHF 481
HI++ P + F NL LQVL L+ + + GL LR L+L N
Sbjct: 294 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 353
Query: 482 QDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLS 541
QD +D F L + ++ L +N L + +
Sbjct: 354 QD---------------------------LDGNVFRMLANLQNISLQNNRLRQLPGNIFA 386
Query: 542 HLKGIY-LNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLE 600
++ G+ + L N + + + L + + L NP C + W N +L
Sbjct: 387 NVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLG 446
Query: 601 GSEETTCANPPSLRGVKLSDVKLSCGITAIGI 632
C +P ++RG L + ++ + ++ +
Sbjct: 447 TDTVPVCFSPANVRGQSLIIINVNVAVPSVHV 478
Score = 62.4 bits (150), Expect = 1e-09
Identities = 89/324 (27%), Positives = 128/324 (39%), Gaps = 55/324 (16%)
Query: 58 LEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMA 117
L+ N L I + F L+ LT L+L + + I FQ L L L N L +
Sbjct: 154 LQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIP 213
Query: 118 ETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKV 177
+ +G +L+ L L Q I L HN NL+ LYL +NHIS + P F
Sbjct: 214 MGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP-PSIF------- 265
Query: 178 LDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSV 237
L Q L+L GN++K + LG FG PNL
Sbjct: 266 ----------------MQLPQLNRLTL--FGNSLKELSLGI----------FGPMPNL-- 295
Query: 238 IFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCF 297
+ LWL D + + L ++ V L L ++ S IS F
Sbjct: 296 ----------RELWL---YDNHISSLPDNVFSNLRQLQV--LILSRNQISFISPGAFNGL 340
Query: 298 TQLQELDLTATHLKGLPSGM-KGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNV 356
T+L+EL L L+ L + + L L+ + L N QL AN L + ++ N
Sbjct: 341 TELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQ 400
Query: 357 KKLHLGVGCLEKLGNLQTLDLSHN 380
+ +L +G + LG L L L N
Sbjct: 401 LE-NLPLGIFDHLGKLCELRLYDN 423
Score = 59.3 bits (142), Expect = 1e-08
Identities = 96/416 (23%), Positives = 153/416 (36%), Gaps = 36/416 (8%)
Query: 39 CENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQ 98
C + +P LP L+ + ++ F + L L + + +++ I F+
Sbjct: 39 CTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFR 98
Query: 99 SHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGS 158
+ L L L N L + G SL+ L L + ++ NL+ L L
Sbjct: 99 NLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHG 158
Query: 159 NHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLS-LNFNGNNVKGIELG 217
NH+ I L L+ N++ +IS R + NL L N + I +G
Sbjct: 159 NHLEYIPDGAFDHLVGLTKLNLGKNSLTHIS---PRVFQHLGNLQVLRLYENRLTDIPMG 215
Query: 218 AFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVE 277
FD G NL + LQ + L G F + +++
Sbjct: 216 TFD----------GLVNLQEL--ALQQNQIGLLSPGLFHN---------------NHNLQ 248
Query: 278 SLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKG-LNLLKKLVLSVNHFDQL 336
L L + S + + F QL L L LK L G+ G + L++L L NH L
Sbjct: 249 RLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSL 308
Query: 337 CQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLS 396
+N L L + N + + G L L+ L L N ++ D + L+
Sbjct: 309 PDNVFSNLRQLQVLILSRN-QISFISPGAFNGLTELRELSLHTNALQ--DLDGNVFRMLA 365
Query: 397 HLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNL 452
+LQ ++L +N L F L + L +L N P F +L L L L
Sbjct: 366 NLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLE-NLPLGIFDHLGKLCELRL 420
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 78.6 bits (192), Expect = 2e-14
Identities = 103/398 (25%), Positives = 168/398 (42%), Gaps = 35/398 (8%)
Query: 33 ANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWI 92
A + +C GL+ +P LP+ T L S+N L I F L NL + L ++ +
Sbjct: 48 AGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV 107
Query: 93 HEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLE 152
S H +S L L N + + + L SL+ L L I+ + + ++
Sbjct: 108 PSLGAASSHVVS-LFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIK 166
Query: 153 SLYLGSNHISSIKFPK-DFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNV 211
L L N I +++ D +R+L L N I++ +R+ + L+ N N +
Sbjct: 167 ELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNR---ITQLPVRAFKLPRLTQLDLNRNRI 223
Query: 212 KGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGL 271
+ IE L F G +L V+ LQ + L G F GL
Sbjct: 224 RLIE----------GLTFQGLNSLEVL--KLQRNNISKLTDGAF-------------WGL 258
Query: 272 CEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGL-PSGMKGLNLLKKLVLSV 330
+M V L+L+ + +++S + T L +L L+ + + G L +LVLS
Sbjct: 259 SKMHV--LHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSF 316
Query: 331 NHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEAS-DCCS 389
N+ +L + S A SL+ L + N H+ G + L +L+ LDL HN+I + + S
Sbjct: 317 NNLTRLDEESLAELSSLSVLRLSHN-SISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTS 375
Query: 390 LQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDL 427
L L L L N+ + +AF LE L+L
Sbjct: 376 GAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNL 413
Score = 69.7 bits (169), Expect = 8e-12
Identities = 105/432 (24%), Positives = 160/432 (37%), Gaps = 85/432 (19%)
Query: 266 AMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPS---------- 315
A L G SLNL ++ S+I F+ LQE+ L L +PS
Sbjct: 60 AALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVS 119
Query: 316 --------------GMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHL 361
+K L+ L LS+N+ ++ + P + L + GN + L
Sbjct: 120 LFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGN-RIGTL 178
Query: 362 GVGCLEKLG-NLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECP 420
+G + L +L TL LS N I + +L L+ L +L+ N ++ F+
Sbjct: 179 ELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQL---DLNRNRIRLIEGLTFQGLN 235
Query: 421 QLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNH 480
LE+L L + F L + VL+L Y L N L GL L L+L N
Sbjct: 236 SLEVLKLQRNNIS-KLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNS 294
Query: 481 ---------------------FQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSL 519
F + T L + SL VL LS + I + AF L
Sbjct: 295 IARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGL 354
Query: 520 GKMSHVDLSHNSLT------------CDSIDSL---------------SHLKGI-YLNLA 551
+ +DL HN ++ DS+ L S L+G+ +LNL
Sbjct: 355 RSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLG 414
Query: 552 ANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENL--HKLEGSEETTCAN 609
N+I + + +++S + C C L W L L+ TCA+
Sbjct: 415 GNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQ----LKWLPPWLIGRMLQAFVTATCAH 470
Query: 610 PPSLRGVKLSDV 621
P SL+G + V
Sbjct: 471 PESLKGQSIFSV 482
Score = 53.9 bits (128), Expect = 5e-07
Identities = 84/319 (26%), Positives = 132/319 (41%), Gaps = 47/319 (14%)
Query: 313 LPSGMKGLNLLKKLVLSVNHFDQLCQISAANF---PSLTHLYIRGNVKKLHLGVGCLEKL 369
LPS + LNL +++L +I A F P+L +Y+ N +G
Sbjct: 66 LPSWTRSLNL---------SYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASS- 115
Query: 370 GNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAF 429
++ +L L HN I + + QLK L+ L+LS N +++ F P ++ L+LA
Sbjct: 116 -HVVSLFLQHNKIRSVE--GSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAG 172
Query: 430 TR---LHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTI 486
R L + A ++L L++ L LP L L+L N + +
Sbjct: 173 NRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVR----AFKLPRLTQLDLNRNRIR---L 225
Query: 487 TKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGI 546
+ Q + SLEVL L + + AF L KM + L +NSL + SL L +
Sbjct: 226 IEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTAL 285
Query: 547 Y-LNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEET 605
+ L+L+ NSI I H C +H L NL +L +E
Sbjct: 286 HQLHLSNNSIARI-----------------HRKGWSFCQKLHELVLSFNNLTRL---DEE 325
Query: 606 TCANPPSLRGVKLSDVKLS 624
+ A SL ++LS +S
Sbjct: 326 SLAELSSLSVLRLSHNSIS 344
Score = 48.9 bits (115), Expect = 1e-05
Identities = 78/306 (25%), Positives = 124/306 (40%), Gaps = 33/306 (10%)
Query: 49 DTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVL 108
D L + L S N + + R F +L LT LDL R +I I TFQ + L L L
Sbjct: 184 DGLSRSLLTLRLSKNRITQLPVRAF-KLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKL 242
Query: 109 TGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPK 168
N + + + + G + L L + + ++ L L L+L +N I+ I
Sbjct: 243 QRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKG 302
Query: 169 DFPARNLK--VLDFQNNAIHYISREDMRSLEQAINLS-LNFNGNNVKGIELGAFDSTIFQ 225
+ L VL F N ++R D SL + +LS L + N++ I GAF +
Sbjct: 303 WSFCQKLHELVLSFNN-----LTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKG--LR 355
Query: 226 SLNF---------GGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSV 276
SL G + S F+GL + + +L+ + + S L+GL
Sbjct: 356 SLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSG--LEGL----- 408
Query: 277 ESLNLQEHRFSDISSTTFQCFTQLQELDLTA------THLKGLPSGMKGLNLLKKLVLSV 330
E LNL + + F L+EL +++ LK LP + G L + +
Sbjct: 409 EHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATC 468
Query: 331 NHFDQL 336
H + L
Sbjct: 469 AHPESL 474
>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
[Homo sapiens]
Length = 518
Score = 78.6 bits (192), Expect = 2e-14
Identities = 66/284 (23%), Positives = 123/284 (43%), Gaps = 29/284 (10%)
Query: 35 KTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHE 94
K CE+ ++IP+ + ++ L FN + + + F+ L L +L L I+ + E
Sbjct: 43 KIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDE 102
Query: 95 DTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESL 154
D FQ +L L+L+ N + ++ + + +L++L L + L+ L L L
Sbjct: 103 DAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIIL 162
Query: 155 YLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGI 214
+L SN + ++ RNL LD N + +SR L + L L N
Sbjct: 163 HLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQ------ 216
Query: 215 ELGAFDSTIFQSLNFGGTP---NLSVIF---NGLQNSTTQSLWLGTFEDIDDEDISSAML 268
F +NF P NL I+ N +++ + W T+ + + D+S +
Sbjct: 217 ---------FSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTW--TWSSLHNLDLSGNDI 265
Query: 269 KGL------CEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLT 306
+G+ C +++ LNL ++ ++IS T + L + L+
Sbjct: 266 QGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLS 309
Score = 72.4 bits (176), Expect = 1e-12
Identities = 89/355 (25%), Positives = 145/355 (40%), Gaps = 46/355 (12%)
Query: 272 CEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGM-KGLNLLKKLVLSV 330
C + + + H F+DI Q L L ++ L S GLN L L L
Sbjct: 38 CRCDGKIVYCESHAFADIPENISG---GSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDH 94
Query: 331 NHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSL 390
N+ + + + L L + N K +L + NL+ LDLS+N ++ S
Sbjct: 95 NYISSVDEDAFQGIRRLKELILSSN-KITYLHNKTFHPVPNLRNLDLSYNKLQTLQ--SE 151
Query: 391 QLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVL 450
Q K L L L+L N + + F++C L+ LDL + RL
Sbjct: 152 QFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLR----------------- 194
Query: 451 NLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNL--LQTVGSLEVLILSSCGL 508
+ +++ AGL L+ L+L+ N F +K N + +L + L +
Sbjct: 195 --------SLSRNAFAGLLKLKELHLEHNQF-----SKINFAHFPRLFNLRSIYLQWNRI 241
Query: 509 LSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIY-LNLAANSINIISPRLLPILS 567
SI Q + + ++DLS N + + L + LNL +N + IS +
Sbjct: 242 RSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWI 301
Query: 568 QQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETT--CANPPSLRGVKLSD 620
+I LS N +C+ S W K +G++E+T CA P ++G K+SD
Sbjct: 302 SLISITLSGNMWECSRSICPLFYWLK----NFKGNKESTMICAGPKHIQGEKVSD 352
>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
[Homo sapiens]
Length = 590
Score = 78.6 bits (192), Expect = 2e-14
Identities = 66/284 (23%), Positives = 123/284 (43%), Gaps = 29/284 (10%)
Query: 35 KTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHE 94
K CE+ ++IP+ + ++ L FN + + + F+ L L +L L I+ + E
Sbjct: 43 KIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDE 102
Query: 95 DTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESL 154
D FQ +L L+L+ N + ++ + + +L++L L + L+ L L L
Sbjct: 103 DAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIIL 162
Query: 155 YLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGI 214
+L SN + ++ RNL LD N + +SR L + L L N
Sbjct: 163 HLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQ------ 216
Query: 215 ELGAFDSTIFQSLNFGGTP---NLSVIF---NGLQNSTTQSLWLGTFEDIDDEDISSAML 268
F +NF P NL I+ N +++ + W T+ + + D+S +
Sbjct: 217 ---------FSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTW--TWSSLHNLDLSGNDI 265
Query: 269 KGL------CEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLT 306
+G+ C +++ LNL ++ ++IS T + L + L+
Sbjct: 266 QGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLS 309
Score = 72.4 bits (176), Expect = 1e-12
Identities = 89/355 (25%), Positives = 145/355 (40%), Gaps = 46/355 (12%)
Query: 272 CEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGM-KGLNLLKKLVLSV 330
C + + + H F+DI Q L L ++ L S GLN L L L
Sbjct: 38 CRCDGKIVYCESHAFADIPENISG---GSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDH 94
Query: 331 NHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSL 390
N+ + + + L L + N K +L + NL+ LDLS+N ++ S
Sbjct: 95 NYISSVDEDAFQGIRRLKELILSSN-KITYLHNKTFHPVPNLRNLDLSYNKLQTLQ--SE 151
Query: 391 QLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVL 450
Q K L L L+L N + + F++C L+ LDL + RL
Sbjct: 152 QFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLR----------------- 194
Query: 451 NLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNL--LQTVGSLEVLILSSCGL 508
+ +++ AGL L+ L+L+ N F +K N + +L + L +
Sbjct: 195 --------SLSRNAFAGLLKLKELHLEHNQF-----SKINFAHFPRLFNLRSIYLQWNRI 241
Query: 509 LSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIY-LNLAANSINIISPRLLPILS 567
SI Q + + ++DLS N + + L + LNL +N + IS +
Sbjct: 242 RSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWI 301
Query: 568 QQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETT--CANPPSLRGVKLSD 620
+I LS N +C+ S W K +G++E+T CA P ++G K+SD
Sbjct: 302 SLISITLSGNMWECSRSICPLFYWLK----NFKGNKESTMICAGPKHIQGEKVSD 352
>gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]
Length = 1032
Score = 77.4 bits (189), Expect = 4e-14
Identities = 149/621 (23%), Positives = 231/621 (37%), Gaps = 76/621 (12%)
Query: 44 LSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDL----TRC------------ 87
L+ +P LP++ E+L S+N + + + L L LD+ RC
Sbjct: 211 LTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPR 270
Query: 88 QINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISN--LEFIPV 145
+H DTF +L LVL + L ++ + G +L+ L L + + +
Sbjct: 271 HFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAF 330
Query: 146 HNLENLESLYLGSNHISSIKF------PKDFPARNLKVLDFQNNAIHYISREDMRSLE-- 197
L L L L N+ + F P LK LD + +R L
Sbjct: 331 QGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARL 390
Query: 198 ---QAINLSLNFNGNNVKGIELGAFDSTIFQSLN---FGGTPNLSVIFNGLQNSTTQSLW 251
Q + L +NF GI AF + L+ G L+ L
Sbjct: 391 PMLQTLRLQMNFINQAQLGI-FRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQ 449
Query: 252 LGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLK 311
G + SS + C +L+L + + F + LQ L L+ +
Sbjct: 450 PGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCIS 509
Query: 312 GLPSGMKGLNL--LKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHL-GVG---- 364
+G + L L L+ L LS N D + S P L L + N + + GVG
Sbjct: 510 QAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFS 569
Query: 365 CLEKLGNLQTLDLSHNDIE---ASDCCSLQLKNLSHLQTLNLSHNEPLG-LQSQAFKECP 420
+ L L+ L L+HN+I + CS L+ L L H G L F+
Sbjct: 570 FVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNA-LGHMWAEGDLYLHFFQGLS 628
Query: 421 QLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNH 480
L LDL+ RLH PQ+ LQVL L +L L LP L L+L GN
Sbjct: 629 GLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQ 688
Query: 481 FQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSL 540
+ T GSL + ++ +D+S NS++ +
Sbjct: 689 LK---------ALTNGSLP------------------AGTRLRRLDVSCNSISFVAPGFF 721
Query: 541 SHLKGI-YLNLAANSINIISPRLL-PILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHK 598
S K + LNL+AN++ + P+ S +++S NPL C C F+ + E
Sbjct: 722 SKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCAC-GAAFMDFLLEVQAA 780
Query: 599 LEG-SEETTCANPPSLRGVKL 618
+ G C +P L+G+ +
Sbjct: 781 VPGLPSRVKCGSPGQLQGLSI 801
Score = 55.1 bits (131), Expect = 2e-07
Identities = 157/669 (23%), Positives = 253/669 (37%), Gaps = 122/669 (18%)
Query: 31 KEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIH--NRTFSRLM-------NLTF 81
+ N +NC +GLS P P +F +PT+ N +++ +M +L
Sbjct: 90 RHLNLKWNCPPVGLS--PMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLIS 147
Query: 82 LDLTRCQINWIHEDTFQSHHQLSTLVLTGN--------PLIFMAETSLNGPKSLKHLFLI 133
L L+ I + + H L L + GN + +A +L G +L HL L
Sbjct: 148 LSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSL- 206
Query: 134 QTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARN-LKVLDFQNNAIHYISRED 192
+NL +P + +LE L L N I + P+D L+VLD N
Sbjct: 207 --KYNNLTVVPRNLPSSLEYLLLSYNRIVKLA-PEDLANLTALRVLDVGGNC-------- 255
Query: 193 MRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWL 252
R + A N + + F L+ +LS + GL + WL
Sbjct: 256 -RRCDHAPNPCMECPRH--------------FPQLHPDTFSHLSRL-EGLVLKDSSLSWL 299
Query: 253 GTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISST-TFQCFTQLQELDLTATHLK 311
+++ +GL + V L+ + + I+ T FQ TQL++L+L+ + K
Sbjct: 300 -----------NASWFRGLGNLRVLDLS-ENFLYKCITKTKAFQGLTQLRKLNLSFNYQK 347
Query: 312 -------GLPSGMKGLNLLKKLVLSVNHFDQLCQISA---ANFPSLTHLYIRGN-VKKLH 360
L L LK+L + F L + + A P L L ++ N + +
Sbjct: 348 RVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQ 407
Query: 361 LGVGCLEKLGNLQTLDLSHNDIEASDCCSLQL---------------------------- 392
LG+ L+ +DLS N I + + +
Sbjct: 408 LGI--FRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSED 465
Query: 393 --KNLSHLQ-TLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQV 449
N S L TL+LS N + +Q + F + L+ L L+ + S F L LQV
Sbjct: 466 FRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQV 525
Query: 450 LNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLL 509
L+L++ LD ++H LP L L+L N G + V L L S
Sbjct: 526 LDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHN 585
Query: 510 SIDQQAFHSLGKMS--HVDLSHNS---------LTCDSIDSLSHLKGIYLNLAANSINII 558
+I Q L S +D S N+ L LS L I+L+L+ N ++ +
Sbjct: 586 NIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGL--IWLDLSQNRLHTL 643
Query: 559 SPRLLPILSQQ-STINLSHNPLD-CTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGV 616
P+ L L + + L N L ++HFL K + L G++ N G
Sbjct: 644 LPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLP--KLEVLDLAGNQLKALTNGSLPAGT 701
Query: 617 KLSDVKLSC 625
+L + +SC
Sbjct: 702 RLRRLDVSC 710
Score = 44.7 bits (104), Expect = 3e-04
Identities = 67/255 (26%), Positives = 106/255 (41%), Gaps = 52/255 (20%)
Query: 370 GNLQTLDLSHNDIE-ASDCCSLQLKNLSHLQTLNLSHN-EPLGL-----------QSQAF 416
GN+ +L LS N I D L +L HL NL N P+GL + F
Sbjct: 63 GNVTSLSLSSNRIHHLHDSDFAHLPSLRHL---NLKWNCPPVGLSPMHFPCHMTIEPSTF 119
Query: 417 KECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNL 476
P LE L+L++ + + P P ++L L + + LD+++ LAGL LR L +
Sbjct: 120 LAVPTLEELNLSYNNI-MTVPALP-KSLISLSLSHTNILMLDSAS---LAGLHALRFLFM 174
Query: 477 KGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDS 536
GN + + L + A LG ++H+ L +N+LT
Sbjct: 175 DGNCYYKNPCRQA-------------------LEVAPGALLGLGNLTHLSLKYNNLTVVP 215
Query: 537 IDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINL-------SHNPLDCTCSNIHFL 589
+ S L+ YL L+ N I ++P L L+ +++ H P C HF
Sbjct: 216 RNLPSSLE--YLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFP 273
Query: 590 TWYKE---NLHKLEG 601
+ + +L +LEG
Sbjct: 274 QLHPDTFSHLSRLEG 288
Score = 35.0 bits (79), Expect = 0.22
Identities = 56/221 (25%), Positives = 83/221 (37%), Gaps = 40/221 (18%)
Query: 326 LVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLG-----------VGCLEKLGNLQT 374
L LS N L A+ PSL HL ++ N + L + L+
Sbjct: 68 LSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEE 127
Query: 375 LDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHI 434
L+LS+N+I L +LS LSH L L S + L L + +
Sbjct: 128 LNLSYNNIMTVPALPKSLISLS------LSHTNILMLDSASLAGLHALRFLFMDGNCYYK 181
Query: 435 NAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQT 494
N + Q L + L GL L HL+LK N+ T+ NL
Sbjct: 182 NPCR---------QALEVA--------PGALLGLGNLTHLSLKYNNL---TVVPRNL--- 218
Query: 495 VGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCD 535
SLE L+LS ++ + + +L + +D+ N CD
Sbjct: 219 PSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCD 259
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 77.0 bits (188), Expect = 5e-14
Identities = 111/483 (22%), Positives = 184/483 (38%), Gaps = 91/483 (18%)
Query: 138 SNLEFIPVHNLENLESLY---LGSNHISSIKFPKDFP-ARNLKVLDFQNNAIHYISREDM 193
+ L FI ++ +L+SL L +N + +I P P + N+ +L N I I E +
Sbjct: 24 NRLSFIKASSMSHLQSLREVKLNNNELETI--PNLGPVSANITLLSLAGNRIVEILPEHL 81
Query: 194 RSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLG 253
+ + L L+ NN+ ++ T F P L + + L ++ S+ G
Sbjct: 82 KEFQSLETLDLS--SNNISELQ------TAF--------PALQLKYLYLNSNRVTSMEPG 125
Query: 254 TFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGL 313
F+++ + ++ L L +R S I F+ QLQ L+L +K +
Sbjct: 126 YFDNLAN--------------TLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNV 170
Query: 314 PS-GMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNL 372
+GL LK L + N +L G L N+
Sbjct: 171 DGLTFQGLGALKSLKMQRNGVTKLMD-------------------------GAFWGLSNM 205
Query: 373 QTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRL 432
+ L L HN++ ++ L L LQ L+LS N + A++ C +L LDL F L
Sbjct: 206 EILQLDHNNL--TEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHL 263
Query: 433 HINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLL 492
S F L L L++ + GL L+ L+LK N
Sbjct: 264 S-RLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAF 322
Query: 493 QTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAA 552
+ L LIL + SI ++AF L + H+DLS N++ ++ S +K +
Sbjct: 323 SGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKL------ 376
Query: 553 NSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPS 612
++L+ + L C C W EN + +CA+P
Sbjct: 377 -----------------QQLHLNTSSLLCDCQLKWLPQWVAEN--NFQSFVNASCAHPQL 417
Query: 613 LRG 615
L+G
Sbjct: 418 LKG 420
Score = 43.1 bits (100), Expect = 8e-04
Identities = 58/257 (22%), Positives = 94/257 (36%), Gaps = 30/257 (11%)
Query: 56 EFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIF 115
+ LE + N + + TF L L L + R + + + F + L L N L
Sbjct: 158 QHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE 217
Query: 116 MAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNL 175
+ + L G L+ L L Q I+ + + L L L NH+S + L
Sbjct: 218 ITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLL 277
Query: 176 KVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLN--FGGTP 233
L NN + YI+ R L L L N E+ S + +N F G
Sbjct: 278 NTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN-------EI----SWTIEDMNGAFSGLD 326
Query: 234 NLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTT 293
L + LQ + +S+ F +D ++E L+L ++ +
Sbjct: 327 KLRRLI--LQGNRIRSITKKAFTGLD---------------ALEHLDLSDNAIMSLQGNA 369
Query: 294 FQCFTQLQELDLTATHL 310
F +LQ+L L + L
Sbjct: 370 FSQMKKLQQLHLNTSSL 386
Score = 31.6 bits (70), Expect = 2.4
Identities = 27/81 (33%), Positives = 43/81 (53%), Gaps = 12/81 (14%)
Query: 498 LEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGI-YLNLAANSIN 556
++VL+L S LL FH +S DLSHN L+ S+SHL+ + + L N +
Sbjct: 2 VDVLLLFSLCLL------FH----ISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELE 51
Query: 557 IISPRLLPILSQQSTINLSHN 577
I P L P+ + + ++L+ N
Sbjct: 52 TI-PNLGPVSANITLLSLAGN 71
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 76.6 bits (187), Expect = 7e-14
Identities = 86/290 (29%), Positives = 133/290 (45%), Gaps = 18/290 (6%)
Query: 295 QCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRG 354
+ T L+ L L T L LP + L L+ L +S N+ L ++ PSL + R
Sbjct: 30 KAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTL-HGELSSLPSLRAIVARA 88
Query: 355 NVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQ 414
N K + KL +L LDLSHN + C +L+N ++ LNLSHN + +Q
Sbjct: 89 NSLKNSGVPDDIFKLDDLSVLDLSHNQLTE---CPRELENAKNMLVLNLSHNSIDTIPNQ 145
Query: 415 AFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHL 474
F L LDL+ RL PQ + L LQ L L L + L + L+ L
Sbjct: 146 LFINLTDLLYLDLSENRLESLPPQ--MRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTL 203
Query: 475 NLKGNHFQDGTITKTNLLQTVGSLEVL--ILSSCGLLSIDQQAFHSLGKMSHVDLSHNSL 532
+L+ T++NL ++ L L + SC L+ + ++L + ++LS N +
Sbjct: 204 HLRSTQ-----RTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQI 258
Query: 533 TCDS--IDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLD 580
T S ID H++ LNL+ N + + P + LS+ + L+ N LD
Sbjct: 259 TELSLCIDQWVHVE--TLNLSRNQLTSL-PSAICKLSKLKKLYLNSNKLD 305
Score = 60.1 bits (144), Expect = 6e-09
Identities = 103/382 (26%), Positives = 154/382 (40%), Gaps = 64/382 (16%)
Query: 156 LGSNHISSIKFPKDFPAR-NLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGI 214
L N FP++ A +L+ L + Y+ E++ +L++ +LS++ N
Sbjct: 15 LSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLP-EELAALQKLEHLSVSHNNLTTLHG 73
Query: 215 ELGAFDSTIFQSLNFGGTPNLSVIF---NGLQNSTTQSLWLGTFEDIDDEDISSAMLKGL 271
EL + P+L I N L+NS + +D+ D+S L
Sbjct: 74 ELSSL-------------PSLRAIVARANSLKNSGVPDD-IFKLDDLSVLDLSHNQLTE- 118
Query: 272 CEMSVES------LNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKK 325
C +E+ LNL + I + F T L LDL+ L+ LP M+ L L+
Sbjct: 119 CPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQT 178
Query: 326 LVLSVNHF--DQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIE 383
LVL+ N QL Q+ A +L L++R + LE L NL +DLS ND+
Sbjct: 179 LVLNGNPLLHAQLRQLPA--MTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLT 236
Query: 384 ASDCC-----SLQLKNLS---------------HLQTLNLSHNEPLGLQSQAFKECPQLE 423
C SL+ NLS H++TLNLS N+ L S A + +L+
Sbjct: 237 RVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPS-AICKLSKLK 295
Query: 424 LLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHL----LAGLPVLRHLNLKGN 479
L L +L + S L NL +N L L P LR L L N
Sbjct: 296 KLYLNSNKLDFDGLPSGIGKL-----TNLEEFMAANNNLELVPESLCRCPKLRKLVLNKN 350
Query: 480 HFQDGTITKTNLLQTVGSLEVL 501
H +T + + +EVL
Sbjct: 351 HL----VTLPEAIHFLTEIEVL 368
Score = 45.8 bits (107), Expect = 1e-04
Identities = 51/168 (30%), Positives = 78/168 (46%), Gaps = 10/168 (5%)
Query: 44 LSEIPDTLPNTTEFL--EFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHH 101
L+E P L N L S N + TI N+ F L +L +LDL+ ++ + + H
Sbjct: 116 LTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVH 175
Query: 102 QLSTLVLTGNPLIFMAETSLNGPKSLK--HLFLIQTGISNLEFIPVHNLENLESLYLGSN 159
L TLVL GNPL+ L +L+ HL Q SNL + L NL + L N
Sbjct: 176 -LQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLP-TSLEGLSNLADVDLSCN 233
Query: 160 HISSIKFPKD-FPARNLKVLDFQNNAIHYISR-EDMRSLEQAINLSLN 205
++ + P+ + +L+ L+ +N I +S D + +NLS N
Sbjct: 234 DLTRV--PECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRN 279
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 76.6 bits (187), Expect = 7e-14
Identities = 83/316 (26%), Positives = 137/316 (43%), Gaps = 48/316 (15%)
Query: 311 KGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYI----RGNVKKLHLGVGCL 366
+G+PS + LNL++ + + I A F L HL + R +++++ VG
Sbjct: 71 QGIPSNTRYLNLME---------NNIQMIQADTFRHLHHLEVLQLGRNSIRQIE--VGAF 119
Query: 367 EKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLD 426
L +L TL+L N + + + LS L+ L L +N + S AF P L LD
Sbjct: 120 NGLASLNTLELFDNWLTVIPSGAFEY--LSKLRELWLRNNPIESIPSYAFNRVPSLMRLD 177
Query: 427 LAFTRLHINAPQSPFQNLHFLQVLNLTYCFL-DTSNQHLLAGLPVLRHLNLKGNHFQDGT 485
L + + F+ L L+ LNL C + D N L GL L + GNHF +
Sbjct: 178 LGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGL---EELEMSGNHFPE-- 232
Query: 486 ITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKG 545
+ + SL+ L + + + I++ AF L + ++L+HN+L+ SL H
Sbjct: 233 -IRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLS-----SLPH--- 283
Query: 546 IYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEET 605
++ +P L ++L HNP +C C +I +L W+ +
Sbjct: 284 ----------DLFTP-----LRYLVELHLHHNPWNCDC-DILWLAWWLREYIPTNSTCCG 327
Query: 606 TCANPPSLRGVKLSDV 621
C P +RG L +V
Sbjct: 328 RCHAPMHMRGRYLVEV 343
Score = 55.1 bits (131), Expect = 2e-07
Identities = 53/186 (28%), Positives = 79/186 (42%), Gaps = 13/186 (6%)
Query: 39 CENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQ 98
C GLSE+P +P+ T +L N + I TF L +L L L R I I F
Sbjct: 61 CTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFN 120
Query: 99 SHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGS 158
L+TL L N L + + L+ L+L I ++ + + +L L LG
Sbjct: 121 GLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGE 180
Query: 159 ----NHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINL-SLNFNGNNVKG 213
+IS F F NLK L+ + + +DM +L + L L +GN+
Sbjct: 181 LKKLEYISEGAFEGLF---NLKYLN-----LGMCNIKDMPNLTPLVGLEELEMSGNHFPE 232
Query: 214 IELGAF 219
I G+F
Sbjct: 233 IRPGSF 238
Score = 39.7 bits (91), Expect = 0.009
Identities = 35/119 (29%), Positives = 53/119 (44%), Gaps = 2/119 (1%)
Query: 65 LPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGP 124
L I F L NL +L+L C I + T L L ++GN + S +G
Sbjct: 184 LEYISEGAFEGLFNLKYLNLGMCNIKDMPNLT--PLVGLEELEMSGNHFPEIRPGSFHGL 241
Query: 125 KSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNN 183
SLK L+++ + +S +E L +L L L N++SS+ P R L L +N
Sbjct: 242 SSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHN 300
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 76.3 bits (186), Expect = 9e-14
Identities = 93/375 (24%), Positives = 155/375 (41%), Gaps = 45/375 (12%)
Query: 257 DIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQ-LQELDLTATHLKGLPS 315
D+ IS M ++ LNL +R + + + F + L + L + +P
Sbjct: 150 DLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPP 209
Query: 316 GMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGN-VKKLHLGVGCLEKLGNLQT 374
+ L L+ L L N + ++ SL L ++ N + KL G L N++
Sbjct: 210 KIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLK--DGAFFGLNNMEE 267
Query: 375 LDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHI 434
L+L HN++ + L L LQ L +S N + A++ C +L LDL++ +L
Sbjct: 268 LELEHNNLTRVN--KGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQL-T 324
Query: 435 NAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAG----LPVLRHLNLKGNHFQDGTITKTN 490
+S F L L+ LNL D H+ G L L+ L+L+ N +
Sbjct: 325 RLDESAFVGLSLLERLNLG----DNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASE 380
Query: 491 LLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTC--DSIDSLSHLKGIYL 548
+ SL LIL + SI ++AF L + H+DL++N++ ++ S +HLK + L
Sbjct: 381 AFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELIL 440
Query: 549 NLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCA 608
N ++ L C C L W +N + S +CA
Sbjct: 441 NTSS--------------------------LLCDCHLKWLLQWLVDN--NFQHSVNVSCA 472
Query: 609 NPPSLRGVKLSDVKL 623
+P L G + +V L
Sbjct: 473 HPEWLAGQSILNVDL 487
Score = 74.7 bits (182), Expect = 3e-13
Identities = 114/444 (25%), Positives = 176/444 (39%), Gaps = 84/444 (18%)
Query: 51 LPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTG 110
LP T L+FS HNR + ++L L ++N+ ++L+ + G
Sbjct: 73 LPPDTAILDFS-------HNRLSNWNISLESQTLQEVKMNY---------NELTEIPYFG 116
Query: 111 NPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDF 170
P TS SL H + + L+F P LESL L SN IS IK F
Sbjct: 117 EP------TSNITLLSLVHNIIPEINAQALQFYPA-----LESLDLSSNIISEIK-TSSF 164
Query: 171 PARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFG 230
P LK L+ NN I + +L ++ L + N N + I F Q L
Sbjct: 165 PRMQLKYLNLSNNRITTLEAGCFDNLSSSL-LVVKLNRNRMSMIPPKIFKLPHLQFLEL- 222
Query: 231 GTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDIS 290
N I GL TF+ +D S+ SL +Q + S +
Sbjct: 223 -KRNRIKIVEGL-----------TFQGLD---------------SLRSLKMQRNGISKLK 255
Query: 291 STTFQCFTQLQELDLTATHLKGLPSG-MKGLNLLKKLVLSVN------------------ 331
F ++EL+L +L + G + GL +L++L +S N
Sbjct: 256 DGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSE 315
Query: 332 ---HFDQLCQISAANFPSLTHL--YIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIE-AS 385
++QL ++ + F L+ L G+ + H+ G L NLQTLDL +N+I A
Sbjct: 316 LDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAI 375
Query: 386 DCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLH 445
+ S L+ L L L N+ + +AF LE LDL + ++ ++ F H
Sbjct: 376 EDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAI-MSIQENAFSQTH 434
Query: 446 FLQ-VLNLTYCFLDTSNQHLLAGL 468
+ +LN + D + LL L
Sbjct: 435 LKELILNTSSLLCDCHLKWLLQWL 458
Score = 52.4 bits (124), Expect = 1e-06
Identities = 57/207 (27%), Positives = 90/207 (43%), Gaps = 26/207 (12%)
Query: 396 SHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRL-HINAPQSPFQNLHFLQVLNLTY 454
S++ L+L HN + +QA + P LE LDL+ + I P L +L + N
Sbjct: 120 SNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRI 179
Query: 455 ------CFLDTSNQHLLA---------------GLPVLRHLNLKGNHFQDGTITKTNLLQ 493
CF + S+ L+ LP L+ L LK N + I + Q
Sbjct: 180 TTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIK---IVEGLTFQ 236
Query: 494 TVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGI-YLNLAA 552
+ SL L + G+ + AF L M ++L HN+LT + L L+ + L ++
Sbjct: 237 GLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQ 296
Query: 553 NSINIISPRLLPILSQQSTINLSHNPL 579
N+I ISP + S ++LS+N L
Sbjct: 297 NAIERISPDAWEFCQRLSELDLSYNQL 323
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,588,067
Number of Sequences: 37866
Number of extensions: 1005834
Number of successful extensions: 4883
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 176
Number of HSP's successfully gapped in prelim test: 108
Number of HSP's that attempted gapping in prelim test: 2543
Number of HSP's gapped (non-prelim): 1190
length of query: 661
length of database: 18,247,518
effective HSP length: 109
effective length of query: 552
effective length of database: 14,120,124
effective search space: 7794308448
effective search space used: 7794308448
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.