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Search of human proteins with 166235148
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166235148 osteoclast stimulating factor 1 [Homo sapiens]
(214 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166235148 osteoclast stimulating factor 1 [Homo sapiens] 442 e-124
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 71 6e-13
gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens] 70 2e-12
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 68 5e-12
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 68 5e-12
gi|14150169 acyl-coenzyme A binding domain containing 6 [Homo sa... 66 3e-11
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 65 4e-11
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens] 65 6e-11
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 64 1e-10
gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Ho... 64 1e-10
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 62 3e-10
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 62 3e-10
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom... 62 3e-10
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo... 62 3e-10
gi|4505573 PAK-interacting exchange factor beta isoform a [Homo ... 62 3e-10
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 62 3e-10
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 62 3e-10
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens] 62 5e-10
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 61 8e-10
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 61 8e-10
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 60 1e-09
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 60 1e-09
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 60 1e-09
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 60 1e-09
gi|14195601 protein phosphatase 1, regulatory (inhibitor) subuni... 60 2e-09
gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit... 60 2e-09
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 60 2e-09
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 60 2e-09
gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens] 59 2e-09
gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens] 59 3e-09
>gi|166235148 osteoclast stimulating factor 1 [Homo sapiens]
Length = 214
Score = 442 bits (1136), Expect = e-124
Identities = 214/214 (100%), Positives = 214/214 (100%)
Query: 1 MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGL 60
MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGL
Sbjct: 1 MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGL 60
Query: 61 IPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKD 120
IPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKD
Sbjct: 61 IPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKD 120
Query: 121 IVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMA 180
IVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMA
Sbjct: 121 IVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMA 180
Query: 181 TNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSD 214
TNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSD
Sbjct: 181 TNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSD 214
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 71.2 bits (173), Expect = 6e-13
Identities = 46/131 (35%), Positives = 69/131 (52%), Gaps = 8/131 (6%)
Query: 56 GRTGLIP------SNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTA 109
GR LIP +N A A+ PLH A ++G+ ++ LD+ N D +G+T
Sbjct: 755 GRADLIPLLLKHGANAGARNADQAV-PLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTP 813
Query: 110 LYWACHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLR 169
L +AC GGH ++V +L Q +N N G+TALH A + + +V+LLL GA +
Sbjct: 814 LIYACSGGHHELVALLL-QHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVL 872
Query: 170 NIEKKLAFDMA 180
N ++ A D A
Sbjct: 873 NKRQRTAVDCA 883
Score = 63.5 bits (153), Expect = 1e-10
Identities = 39/117 (33%), Positives = 61/117 (52%), Gaps = 2/117 (1%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEML--FTQPNIEL 133
PLH A ++G S L + D G+T L+ AC GH+D V+ L + + L
Sbjct: 499 PLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRL 558
Query: 134 NQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLK 190
+ N+ GDT LH AA GY +++ LL GA T+++N K+ A N+ S+++
Sbjct: 559 DIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVME 615
Score = 34.7 bits (78), Expect = 0.062
Identities = 17/48 (35%), Positives = 27/48 (56%)
Query: 133 LNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMA 180
+N ++ G + LH AA G AD++ LLL GA RN ++ + +A
Sbjct: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLA 784
Score = 28.5 bits (62), Expect = 4.5
Identities = 13/25 (52%), Positives = 17/25 (68%)
Query: 140 GDTALHAAAWKGYADIVQLLLAKGA 164
G T LH AA G A ++ LL++KGA
Sbjct: 463 GHTPLHVAAVCGQASLIDLLVSKGA 487
>gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens]
Length = 327
Score = 69.7 bits (169), Expect = 2e-12
Identities = 38/103 (36%), Positives = 59/103 (57%), Gaps = 1/103 (0%)
Query: 77 LHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQ 136
LH A+ G++ L + LDN V+ D+ TA++WAC GGH ++V++L + + N +
Sbjct: 185 LHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSH-GADTNVR 243
Query: 137 NKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDM 179
+K GDTALH A I++LLL GA +N+ K D+
Sbjct: 244 DKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 286
Score = 49.7 bits (117), Expect = 2e-06
Identities = 41/145 (28%), Positives = 68/145 (46%), Gaps = 6/145 (4%)
Query: 51 KGTSKGRTGLIPSNYVAEQAESIDNPLHE-----AAKRGNLSWLRECLDNRVGVNGLDKA 105
K K R L S+ + E I P+ E AA G + + + L + + D+
Sbjct: 121 KRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQF 180
Query: 106 GSTALYWACHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGAR 165
TAL+ A GH +I+E L ++ Q++L TA+H A G+ ++V+LL + GA
Sbjct: 181 RRTALHRASLEGHMEILEKLLDN-GATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGAD 239
Query: 166 TDLRNIEKKLAFDMATNAACASLLK 190
T++R+ E A A ++K
Sbjct: 240 TNVRDKEGDTALHDAVRLNRYKIIK 264
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 68.2 bits (165), Expect = 5e-12
Identities = 48/148 (32%), Positives = 74/148 (50%), Gaps = 6/148 (4%)
Query: 66 VAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEML 125
V ++ E + PLH AA RG++ ++E + VN D AG T L+ AC+ G+ D+ ++L
Sbjct: 155 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 214
Query: 126 FTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAAC 185
++N Q DT LH +A G+ DIV+LLL G N + D+A
Sbjct: 215 IA-AGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEEL 273
Query: 186 ASLLKKKQGTDAVRTLSNAEDYLDDEDS 213
LLK++ V + E Y D E++
Sbjct: 274 ELLLKRE-----VPLSDDDESYTDSEEA 296
Score = 30.0 bits (66), Expect = 1.5
Identities = 13/39 (33%), Positives = 27/39 (69%)
Query: 132 ELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRN 170
++N++N+ G+T LH AA +G V+ L++ GA ++++
Sbjct: 154 KVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKD 192
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 68.2 bits (165), Expect = 5e-12
Identities = 48/148 (32%), Positives = 74/148 (50%), Gaps = 6/148 (4%)
Query: 66 VAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEML 125
V ++ E + PLH AA RG++ ++E + VN D AG T L+ AC+ G+ D+ ++L
Sbjct: 178 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 237
Query: 126 FTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAAC 185
++N Q DT LH +A G+ DIV+LLL G N + D+A
Sbjct: 238 IA-AGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEEL 296
Query: 186 ASLLKKKQGTDAVRTLSNAEDYLDDEDS 213
LLK++ V + E Y D E++
Sbjct: 297 ELLLKRE-----VPLSDDDESYTDSEEA 319
Score = 30.0 bits (66), Expect = 1.5
Identities = 13/39 (33%), Positives = 27/39 (69%)
Query: 132 ELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRN 170
++N++N+ G+T LH AA +G V+ L++ GA ++++
Sbjct: 177 KVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKD 215
>gi|14150169 acyl-coenzyme A binding domain containing 6 [Homo
sapiens]
Length = 282
Score = 65.9 bits (159), Expect = 3e-11
Identities = 44/137 (32%), Positives = 71/137 (51%), Gaps = 3/137 (2%)
Query: 60 LIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNR-VGVNGLDKAGSTALYWACHGGH 118
+I S Y E D + + + N+ + + + ++ V VN D+ G L+WAC GH
Sbjct: 145 VISSLYHEETIREEDKNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGH 204
Query: 119 KDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFD 178
K++V +L Q ++N Q+ G TALH A+ + DIV+LLL GA LR+ + L +
Sbjct: 205 KELVTVLL-QHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLP-E 262
Query: 179 MATNAACASLLKKKQGT 195
T SL+ ++ T
Sbjct: 263 EVTGCKTVSLVLQRHTT 279
Score = 32.0 bits (71), Expect = 0.40
Identities = 21/98 (21%), Positives = 46/98 (46%)
Query: 114 CHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEK 173
C + D + N+++N +++ G LH A +G+ ++V +LL A + ++ E
Sbjct: 166 CRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEG 225
Query: 174 KLAFDMATNAACASLLKKKQGTDAVRTLSNAEDYLDDE 211
+ A A+ +++ + A TL + + L +E
Sbjct: 226 QTALHYASACEFLDIVELLLQSGADPTLRDQDGCLPEE 263
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 65.1 bits (157), Expect = 4e-11
Identities = 49/160 (30%), Positives = 77/160 (48%), Gaps = 15/160 (9%)
Query: 63 SNYVAEQAESIDNP-LHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDI 121
SNY Q P L AA GN+ L+ + ++ DK GS A+YWA GH D
Sbjct: 368 SNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDT 427
Query: 122 VEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMAT 181
++ L ++ L+ ++K G+ ALH AA G+AD+ QLL + G+ ++++ E++ A
Sbjct: 428 LKFL-SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAA 486
Query: 182 ------------NAACASLLKKKQGTDAVRTLSNAEDYLD 209
A C +K ++G + T S A Y D
Sbjct: 487 WHGYYSVAKALCEAGCNVNIKNREGETPLLTAS-ARGYHD 525
Score = 55.1 bits (131), Expect = 4e-08
Identities = 36/104 (34%), Positives = 52/104 (50%), Gaps = 1/104 (0%)
Query: 77 LHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQ 136
LH A +R + ++ L V+ D+ G+T L+ AC G+ IV L + N L+
Sbjct: 548 LHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVAL-CEANCNLDIS 606
Query: 137 NKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMA 180
NK G T LH AA G D+V+ L GA + + K A D+A
Sbjct: 607 NKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLA 650
Score = 48.1 bits (113), Expect = 5e-06
Identities = 36/148 (24%), Positives = 67/148 (45%), Gaps = 32/148 (21%)
Query: 75 NPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFT---QPNI 131
N ++ AA+ G++ L+ +N+ ++ DK+G AL+ A GH D+ ++L + PNI
Sbjct: 414 NAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNI 473
Query: 132 E-----------------------------LNQQNKLGDTALHAAAWKGYADIVQLLLAK 162
+ +N +N+ G+T L A+ +GY DIV+ L
Sbjct: 474 QDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEH 533
Query: 163 GARTDLRNIEKKLAFDMATNAACASLLK 190
GA + + + +A +A ++K
Sbjct: 534 GADLNACDKDGHIALHLAVRRCQMEVIK 561
Score = 46.6 bits (109), Expect = 2e-05
Identities = 32/102 (31%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Query: 69 QAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQ 128
Q + + PLH AA G S + + VN ++ G T L A G+ DIVE L +
Sbjct: 474 QDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECL-AE 532
Query: 129 PNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRN 170
+LN +K G ALH A + ++++ LL++G D ++
Sbjct: 533 HGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQD 574
Score = 39.7 bits (91), Expect = 0.002
Identities = 31/110 (28%), Positives = 51/110 (46%), Gaps = 3/110 (2%)
Query: 74 DNPLHEAAKRGNLSWLRECL-DNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIE 132
+ PL A+ RG + ECL ++ +N DK G AL+ A ++++ L +Q
Sbjct: 512 ETPLLTASARGYHD-IVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ-GCF 569
Query: 133 LNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATN 182
++ Q++ G+T LH A G IV L D+ N + +A N
Sbjct: 570 VDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAAN 619
Score = 35.0 bits (79), Expect = 0.048
Identities = 24/73 (32%), Positives = 38/73 (52%), Gaps = 4/73 (5%)
Query: 102 LDKAGSTALYWACHGGHKDIV----EMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQ 157
LD+ S + H + D V +L + N ++NQ NK G L AA G I+Q
Sbjct: 337 LDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQ 396
Query: 158 LLLAKGARTDLRN 170
LL+ +G+R D+++
Sbjct: 397 LLIKRGSRIDVQD 409
Score = 30.0 bits (66), Expect = 1.5
Identities = 20/69 (28%), Positives = 32/69 (46%)
Query: 57 RTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHG 116
+T L +V Q + PLH A K GN+ + + ++ +K G T L+ A +
Sbjct: 561 KTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANN 620
Query: 117 GHKDIVEML 125
G D+V L
Sbjct: 621 GILDVVRYL 629
>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
Length = 360
Score = 64.7 bits (156), Expect = 6e-11
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 1/114 (0%)
Query: 77 LHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQ 136
LH A+ G++ L + LDN V+ D+ TA++WAC GGH ++V++L + + N +
Sbjct: 185 LHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSH-GADTNVR 243
Query: 137 NKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLK 190
+KL T LH A G +IV+ L+ G + R+ E A A ++K
Sbjct: 244 DKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIK 297
Score = 48.5 bits (114), Expect = 4e-06
Identities = 37/125 (29%), Positives = 62/125 (49%), Gaps = 6/125 (4%)
Query: 51 KGTSKGRTGLIPSNYVAEQAESIDNPLHE-----AAKRGNLSWLRECLDNRVGVNGLDKA 105
K K R L S+ + E I P+ E AA G + + + L + + D+
Sbjct: 121 KRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQF 180
Query: 106 GSTALYWACHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGAR 165
TAL+ A GH +I+E L ++ Q++L TA+H A G+ ++V+LL + GA
Sbjct: 181 RRTALHRASLEGHMEILEKLLDN-GATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGAD 239
Query: 166 TDLRN 170
T++R+
Sbjct: 240 TNVRD 244
Score = 30.4 bits (67), Expect = 1.2
Identities = 18/70 (25%), Positives = 32/70 (45%), Gaps = 1/70 (1%)
Query: 73 IDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIE 132
+ PLH A + G + + L + +N D+ G TAL+ A I+++L +
Sbjct: 247 LSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH-GAD 305
Query: 133 LNQQNKLGDT 142
+ +N G T
Sbjct: 306 MMTKNLAGKT 315
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 63.9 bits (154), Expect = 1e-10
Identities = 27/56 (48%), Positives = 35/56 (62%)
Query: 11 PGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGLIPSNYV 66
P Q +AL+ F+P+ EL F GD I++ D SD NWWKG G+TG+ P NYV
Sbjct: 155 PQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYV 210
Score = 44.7 bits (104), Expect = 6e-05
Identities = 20/49 (40%), Positives = 28/49 (57%), Gaps = 1/49 (2%)
Query: 19 ALYTFEPRTPDELYFEEGDIIYI-TDMSDTNWWKGTSKGRTGLIPSNYV 66
A Y F+ DEL F+ GDI+ + + D NW+K G+ G IP NY+
Sbjct: 5 AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI 53
>gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Homo
sapiens]
Length = 176
Score = 63.9 bits (154), Expect = 1e-10
Identities = 27/56 (48%), Positives = 35/56 (62%)
Query: 11 PGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGLIPSNYV 66
P Q +AL+ F+P+ EL F GD I++ D SD NWWKG G+TG+ P NYV
Sbjct: 114 PQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYV 169
Score = 45.1 bits (105), Expect = 5e-05
Identities = 21/58 (36%), Positives = 30/58 (51%), Gaps = 1/58 (1%)
Query: 19 ALYTFEPRTPDELYFEEGDIIYI-TDMSDTNWWKGTSKGRTGLIPSNYVAEQAESIDN 75
A Y F+ DEL F+ GDI+ + + D NW+K G+ G IP NY+ + N
Sbjct: 5 AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPFGN 62
>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 62.4 bits (150), Expect = 3e-10
Identities = 26/53 (49%), Positives = 35/53 (66%)
Query: 16 VFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGLIPSNYVAE 68
V RA + F+ DEL F +GD+I++T + + WW+GT GRTG PSNYV E
Sbjct: 10 VVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 62
>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
sapiens]
Length = 753
Score = 62.4 bits (150), Expect = 3e-10
Identities = 26/53 (49%), Positives = 35/53 (66%)
Query: 16 VFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGLIPSNYVAE 68
V RA + F+ DEL F +GD+I++T + + WW+GT GRTG PSNYV E
Sbjct: 138 VVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 190
>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
sapiens]
Length = 803
Score = 62.4 bits (150), Expect = 3e-10
Identities = 26/53 (49%), Positives = 35/53 (66%)
Query: 16 VFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGLIPSNYVAE 68
V RA + F+ DEL F +GD+I++T + + WW+GT GRTG PSNYV E
Sbjct: 188 VVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 240
>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
sapiens]
Length = 782
Score = 62.4 bits (150), Expect = 3e-10
Identities = 26/53 (49%), Positives = 35/53 (66%)
Query: 16 VFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGLIPSNYVAE 68
V RA + F+ DEL F +GD+I++T + + WW+GT GRTG PSNYV E
Sbjct: 167 VVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 219
>gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 62.4 bits (150), Expect = 3e-10
Identities = 26/53 (49%), Positives = 35/53 (66%)
Query: 16 VFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGLIPSNYVAE 68
V RA + F+ DEL F +GD+I++T + + WW+GT GRTG PSNYV E
Sbjct: 10 VVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 62
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 62.4 bits (150), Expect = 3e-10
Identities = 30/69 (43%), Positives = 42/69 (60%), Gaps = 1/69 (1%)
Query: 16 VFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGLIPSNYVAEQAESIDN 75
+ +A + F+ DEL +GDIIY+T + + WW+GT GRTG PSNYV E +S +
Sbjct: 164 IVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVRE-IKSSER 222
Query: 76 PLHEAAKRG 84
PL A +G
Sbjct: 223 PLSPKAVKG 231
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 62.4 bits (150), Expect = 3e-10
Identities = 45/125 (36%), Positives = 59/125 (47%), Gaps = 1/125 (0%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135
PLH AA NL L++ VN DK G L+ A GH DI +L N +N
Sbjct: 840 PLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKY-NTCVNA 898
Query: 136 QNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLKKKQGT 195
+K T LH AA KG + LLLA GA ++N E + D+AT +LL
Sbjct: 899 TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPP 958
Query: 196 DAVRT 200
+A+ T
Sbjct: 959 EALPT 963
Score = 62.0 bits (149), Expect = 4e-10
Identities = 44/129 (34%), Positives = 64/129 (49%), Gaps = 4/129 (3%)
Query: 75 NPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELN 134
+PLH AA G + L V+ D G L+ AC GH ++V +L Q + N
Sbjct: 218 SPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQ-GADPN 276
Query: 135 QQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASL---LKK 191
++ T LH AA KG D+ +LL GA ++RN + K A D+A +A A L KK
Sbjct: 277 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKK 336
Query: 192 KQGTDAVRT 200
+ +A R+
Sbjct: 337 DELLEAARS 345
Score = 52.0 bits (123), Expect = 4e-07
Identities = 36/105 (34%), Positives = 51/105 (48%), Gaps = 1/105 (0%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135
PLH AA + ++ L + V+ DK G L+ AC GH ++ E+L + +N
Sbjct: 372 PLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLL-KHGACVNA 430
Query: 136 QNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMA 180
+ T LH AA K ++ LLL+ GA L N K A DMA
Sbjct: 431 MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
Score = 49.7 bits (117), Expect = 2e-06
Identities = 34/104 (32%), Positives = 50/104 (48%), Gaps = 1/104 (0%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135
PLH AA +S + L + V+ DK G L+ AC GH ++ E+L + +N
Sbjct: 687 PLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELL-VRHGASVNV 745
Query: 136 QNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDM 179
+ T LH AA KG +I +LLL GA +N + D+
Sbjct: 746 ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789
Score = 43.5 bits (101), Expect = 1e-04
Identities = 36/121 (29%), Positives = 57/121 (47%), Gaps = 8/121 (6%)
Query: 68 EQAESIDNPLHEAA-----KRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIV 122
+Q +S + LH A KR ++ L L VN +K T L+ A H D++
Sbjct: 517 KQPQSHETALHCAVASLHPKRKQVTEL--LLRKGANVNEKNKDFMTPLHVAAERAHNDVM 574
Query: 123 EMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATN 182
E+L ++N + LG TALH AA G+ +LLL+ G+ + +++ A M
Sbjct: 575 EVLHKH-GAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNE 633
Query: 183 A 183
A
Sbjct: 634 A 634
Score = 34.7 bits (78), Expect = 0.062
Identities = 33/109 (30%), Positives = 44/109 (40%), Gaps = 20/109 (18%)
Query: 76 PLHEAAKRGNLSWLRECLD--------NRVGVNGLDKAGSTA------------LYWACH 115
PLHEAA +G + L N G + LD A +A L A
Sbjct: 285 PLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAAR 344
Query: 116 GGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGA 164
G+++ + L T N+ + + T LH AA IVQLLL GA
Sbjct: 345 SGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGA 393
Score = 32.7 bits (73), Expect = 0.24
Identities = 19/62 (30%), Positives = 29/62 (46%)
Query: 66 VAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEML 125
V E+ + PLH AA+R + + + +N LD G TAL+ A GH +L
Sbjct: 551 VNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610
Query: 126 FT 127
+
Sbjct: 611 LS 612
Score = 29.6 bits (65), Expect = 2.0
Identities = 18/58 (31%), Positives = 24/58 (41%)
Query: 113 ACHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRN 170
AC G V+ L N+ + LH AA G D+V+ LL GA R+
Sbjct: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARD 246
>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
Length = 305
Score = 61.6 bits (148), Expect = 5e-10
Identities = 49/145 (33%), Positives = 69/145 (47%), Gaps = 15/145 (10%)
Query: 40 YITDMSDTN-----------W--WKGTSKGRTGLIPSNYVAEQAESIDN-PLHEAAKRGN 85
Y+TD D N W KG S+ L+ + + + +D P+ A + G+
Sbjct: 130 YLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGH 189
Query: 86 LSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKLGDTALH 145
L L++ L+ VN DK GST L+ A H D +E L + LN Q+K GDTALH
Sbjct: 190 LVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI-ECGAHLNAQDKEGDTALH 248
Query: 146 AAAWKGYADIVQLLLAKGARTDLRN 170
A G ++LLL GA +RN
Sbjct: 249 EAVRHGSYKAMKLLLLYGAELGVRN 273
Score = 52.0 bits (123), Expect = 4e-07
Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 1/114 (0%)
Query: 77 LHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQ 136
LH A +G+ + + L V+ D T ++WAC GGH I++ L Q +N +
Sbjct: 148 LHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQ-GARVNAR 206
Query: 137 NKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLK 190
+K+G T LH A + D ++ L+ GA + ++ E A A +K
Sbjct: 207 DKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMK 260
Score = 34.7 bits (78), Expect = 0.062
Identities = 17/38 (44%), Positives = 23/38 (60%)
Query: 134 NQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNI 171
N +KL TALH A KG++ +V LL GA D R++
Sbjct: 138 NAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDL 175
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 60.8 bits (146), Expect = 8e-10
Identities = 36/104 (34%), Positives = 52/104 (50%), Gaps = 1/104 (0%)
Query: 77 LHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQ 136
LH AA G++ + L +N DK AL+WA + GH D+V +L E+ +
Sbjct: 119 LHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH-GAEVTCK 177
Query: 137 NKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMA 180
+K G T LHAAA G ++V+ LL G D N+ A +A
Sbjct: 178 DKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIA 221
Score = 50.1 bits (118), Expect = 1e-06
Identities = 32/105 (30%), Positives = 56/105 (53%), Gaps = 2/105 (1%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135
PLH AA G ++ ++ L+ V ++ ++ G+TAL+ AC+ G +V L +NQ
Sbjct: 184 PLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDY-GANVNQ 242
Query: 136 QNKLGDTALHAAAWKGYADI-VQLLLAKGARTDLRNIEKKLAFDM 179
N G T LH AA + + ++LL+ GA ++++ + K M
Sbjct: 243 PNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHM 287
Score = 48.9 bits (115), Expect = 3e-06
Identities = 30/88 (34%), Positives = 42/88 (47%), Gaps = 5/88 (5%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGL---DKAGSTALYWACHGGHKDIVEMLFTQPNIE 132
PLH AA RG+ +WL E L + D G T L+WAC+ G+++ +E+L Q
Sbjct: 714 PLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFR 773
Query: 133 LNQQNKLGDTALHAAAWKGYADIVQLLL 160
N T LH A + + LLL
Sbjct: 774 KFIGNPF--TPLHCAIINDHGNCASLLL 799
Score = 48.1 bits (113), Expect = 5e-06
Identities = 32/104 (30%), Positives = 50/104 (48%)
Query: 59 GLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGH 118
G I S+ V+ + + PL AA ++ L+ L + VN +D +G TAL A G
Sbjct: 800 GAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQ 859
Query: 119 KDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAK 162
V++L +L ++K +T LH A KG+ L+L K
Sbjct: 860 AGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903
Score = 42.7 bits (99), Expect = 2e-04
Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 1/89 (1%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135
PLH A + ++ + + VN DK T L+ A E++ + +N
Sbjct: 52 PLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLS-SVNV 110
Query: 136 QNKLGDTALHAAAWKGYADIVQLLLAKGA 164
++ G TALH AA G+ ++V LLLAKGA
Sbjct: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGA 139
Score = 42.7 bits (99), Expect = 2e-04
Identities = 34/108 (31%), Positives = 61/108 (56%), Gaps = 14/108 (12%)
Query: 75 NPLHEAAKRGNLSWLRECLD---NRVGVNGLDKAGSTA----LYWACHGGHKDIVEMLFT 127
N +H AA G+ R+CL+ R +G +++ S A L+ A + GH +E+L
Sbjct: 509 NSIHYAAAYGH----RQCLELLLERTN-SGFEESDSGATKSPLHLAAYNGHHQALEVLL- 562
Query: 128 QPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLR-NIEKK 174
Q ++L+ +++ G TAL AA+KG+ + V+ L+ GA ++ N+ K+
Sbjct: 563 QSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKR 610
Score = 42.7 bits (99), Expect = 2e-04
Identities = 31/88 (35%), Positives = 42/88 (47%), Gaps = 4/88 (4%)
Query: 76 PLHEAAKRGNLSWLR---ECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIE 132
PLH + G+ LR E DN V+ D G T L A GH D V +L +
Sbjct: 612 PLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL-EKEAN 670
Query: 133 LNQQNKLGDTALHAAAWKGYADIVQLLL 160
++ + LG TALH G+ + VQ+LL
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLL 698
Score = 42.7 bits (99), Expect = 2e-04
Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 8/102 (7%)
Query: 66 VAEQAESID-------NPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGH 118
+A+ E++D PL A G++ + L+ V+ +D G TAL+ GH
Sbjct: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690
Query: 119 KDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLL 160
++ V+ML Q + + ++ G T LH AA +G+A + LL
Sbjct: 691 EECVQMLLEQ-EVSILCKDSRGRTPLHYAAARGHATWLSELL 731
Score = 42.0 bits (97), Expect = 4e-04
Identities = 30/98 (30%), Positives = 45/98 (45%)
Query: 63 SNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIV 122
S + + + +PLH AA G+ L L + V ++ D+ G TAL A GH + V
Sbjct: 532 SGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECV 591
Query: 123 EMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLL 160
E L + N T LHA+ G+ ++LLL
Sbjct: 592 EALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLL 629
Score = 41.6 bits (96), Expect = 5e-04
Identities = 31/96 (32%), Positives = 45/96 (46%), Gaps = 11/96 (11%)
Query: 74 DNPLHEAAKRGNLSWLRECLDNRVGVNGLDKA-----GSTALYWACHGGHKDIVEMLFTQ 128
+ PLH AA+ G+ E L N + +G D A L+ A H D L +
Sbjct: 315 NTPLHVAARYGH-----ELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSS 369
Query: 129 PNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGA 164
E++ +K G T LHAAA G + ++LL + GA
Sbjct: 370 -GFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGA 404
Score = 40.4 bits (93), Expect = 0.001
Identities = 23/89 (25%), Positives = 45/89 (50%), Gaps = 1/89 (1%)
Query: 93 LDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNK-LGDTALHAAAWKG 151
L N + DK G ++++A GH+ +E+L + N + + + LH AA+ G
Sbjct: 494 LQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNG 553
Query: 152 YADIVQLLLAKGARTDLRNIEKKLAFDMA 180
+ +++LL D+R+ + + A D+A
Sbjct: 554 HHQALEVLLQSLVDLDIRDEKGRTALDLA 582
Score = 38.1 bits (87), Expect = 0.006
Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 1/72 (1%)
Query: 77 LHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQ 136
LH AA GN+ ++ + + DK G T L++A H +E L T +N+
Sbjct: 384 LHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVT-TGANVNET 442
Query: 137 NKLGDTALHAAA 148
+ G TALH AA
Sbjct: 443 DDWGRTALHYAA 454
Score = 31.6 bits (70), Expect = 0.53
Identities = 33/117 (28%), Positives = 49/117 (41%), Gaps = 2/117 (1%)
Query: 76 PLHEAAKRGNLSWLRECL-DNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELN 134
PLH AA + + E L +N VN K G + L+ G + L Q E++
Sbjct: 250 PLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI-QNGGEID 308
Query: 135 QQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLKK 191
+K G+T LH AA G+ ++ L GA T I +A A + +K
Sbjct: 309 CVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRK 365
Score = 30.8 bits (68), Expect = 0.90
Identities = 13/29 (44%), Positives = 21/29 (72%)
Query: 142 TALHAAAWKGYADIVQLLLAKGARTDLRN 170
T LH AA+ G A+I++LL+ GAR + ++
Sbjct: 18 TPLHVAAFLGDAEIIELLILSGARVNAKD 46
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 60.8 bits (146), Expect = 8e-10
Identities = 47/148 (31%), Positives = 73/148 (49%), Gaps = 3/148 (2%)
Query: 66 VAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEML 125
V ++ E + LH AA RG+ ++E + VN D AG TAL+ AC+ G+ D+ + L
Sbjct: 161 VNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQL 220
Query: 126 FTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAAC 185
E+N + DT LH AA G+ +V+LLL G N + + +A +
Sbjct: 221 LA-AGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTM 279
Query: 186 ASLLKKKQGTDAVRTLSNAEDYLDDEDS 213
+LL K GT S+ E ++ED+
Sbjct: 280 VNLLLGK-GTYTSSEESSTES-SEEEDA 305
Score = 32.7 bits (73), Expect = 0.24
Identities = 17/60 (28%), Positives = 35/60 (58%)
Query: 132 ELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLKK 191
++N++N+ G+T LH AA +G A ++ L+++GA ++++ A A N + K+
Sbjct: 160 KVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQ 219
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 60.1 bits (144), Expect = 1e-09
Identities = 45/136 (33%), Positives = 60/136 (44%), Gaps = 33/136 (24%)
Query: 77 LHEAAKRGNLSWLRECLDN-RVGVNGLDKAGSTALYWACHGGHKDIVEMLFT-------- 127
LH AAK GNL + L +V VN D G T + WA H +++ ML T
Sbjct: 721 LHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLT 780
Query: 128 --QPNI----------------------ELNQQNKLGDTALHAAAWKGYADIVQLLLAKG 163
+ NI +L+ N GDT LH AA + Y D V L L++G
Sbjct: 781 DNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRG 840
Query: 164 ARTDLRNIEKKLAFDM 179
A +LRN E A+D+
Sbjct: 841 ANPELRNKEGDTAWDL 856
Score = 47.4 bits (111), Expect = 9e-06
Identities = 50/210 (23%), Positives = 92/210 (43%), Gaps = 29/210 (13%)
Query: 8 PVKPGQVKVFRALYTFEPRT-------PDELYF--EEGD----IIYITDMSDTNWWKGTS 54
P+ PG+ + +AL E P +LY ++G+ I+ + D D N+
Sbjct: 590 PLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQ 649
Query: 55 KGRT--------GLIPSNYVAEQAESIDN--------PLHEAAKRGNLSWLRECLDNRVG 98
RT G + +V QA + N PL EA +L R +
Sbjct: 650 SKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGC 709
Query: 99 VNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQL 158
V ++ GST L+ A G+ ++V +L + +++N Q+ G T + AA + +++++
Sbjct: 710 VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRM 769
Query: 159 LLAKGARTDLRNIEKKLAFDMATNAACASL 188
LL +GA L + E+ + A+ A++
Sbjct: 770 LLTRGADVTLTDNEENICLHWASFTGSAAI 799
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 60.1 bits (144), Expect = 1e-09
Identities = 45/136 (33%), Positives = 60/136 (44%), Gaps = 33/136 (24%)
Query: 77 LHEAAKRGNLSWLRECLDN-RVGVNGLDKAGSTALYWACHGGHKDIVEMLFT-------- 127
LH AAK GNL + L +V VN D G T + WA H +++ ML T
Sbjct: 755 LHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLT 814
Query: 128 --QPNI----------------------ELNQQNKLGDTALHAAAWKGYADIVQLLLAKG 163
+ NI +L+ N GDT LH AA + Y D V L L++G
Sbjct: 815 DNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRG 874
Query: 164 ARTDLRNIEKKLAFDM 179
A +LRN E A+D+
Sbjct: 875 ANPELRNKEGDTAWDL 890
Score = 47.4 bits (111), Expect = 9e-06
Identities = 50/210 (23%), Positives = 92/210 (43%), Gaps = 29/210 (13%)
Query: 8 PVKPGQVKVFRALYTFEPRT-------PDELYF--EEGD----IIYITDMSDTNWWKGTS 54
P+ PG+ + +AL E P +LY ++G+ I+ + D D N+
Sbjct: 624 PLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQ 683
Query: 55 KGRT--------GLIPSNYVAEQAESIDN--------PLHEAAKRGNLSWLRECLDNRVG 98
RT G + +V QA + N PL EA +L R +
Sbjct: 684 SKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGC 743
Query: 99 VNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQL 158
V ++ GST L+ A G+ ++V +L + +++N Q+ G T + AA + +++++
Sbjct: 744 VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRM 803
Query: 159 LLAKGARTDLRNIEKKLAFDMATNAACASL 188
LL +GA L + E+ + A+ A++
Sbjct: 804 LLTRGADVTLTDNEENICLHWASFTGSAAI 833
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 60.1 bits (144), Expect = 1e-09
Identities = 43/136 (31%), Positives = 61/136 (44%), Gaps = 4/136 (2%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135
PL EAA+ G+L ++ L V+ G TAL +AC GH D+ ++L Q +L
Sbjct: 567 PLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL-QAGADLEH 625
Query: 136 QNKLGDTALHAAAWKGYADIVQLLLAKGA---RTDLRNIEKKLAFDMATNAACASLLKKK 192
+++ G T L AA G+ VQ L++KGA RT N L+ A L
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 193 QGTDAVRTLSNAEDYL 208
G D L + L
Sbjct: 686 HGADPTHRLKDGSTML 701
Score = 56.6 bits (135), Expect = 2e-08
Identities = 35/110 (31%), Positives = 57/110 (51%), Gaps = 4/110 (3%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135
PL AA G++ ++ L ++ VN G+TAL +AC GG+ D+V++L + +
Sbjct: 304 PLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL-ESGASIED 362
Query: 136 QNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAAC 185
N+ G T L A G+ ++ +LLL GA + + E K + A AC
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK---ESALTLAC 409
Score = 52.4 bits (124), Expect = 3e-07
Identities = 34/124 (27%), Positives = 55/124 (44%)
Query: 67 AEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLF 126
A+ + D L A G+ ++ L+ + DK G T L A GH +VE+L
Sbjct: 1077 AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 1136
Query: 127 TQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACA 186
Q + DT L A G ++V+LLLA+GA + RN+ +A +
Sbjct: 1137 DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 1196
Query: 187 SLLK 190
+++K
Sbjct: 1197 NIIK 1200
Score = 47.4 bits (111), Expect = 9e-06
Identities = 38/110 (34%), Positives = 53/110 (48%), Gaps = 3/110 (2%)
Query: 66 VAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNG--LDKAGSTALYWACHGGHKDIVE 123
V +A++ PL EAA G R LD VN + + TAL A GH E
Sbjct: 1278 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1337
Query: 124 MLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEK 173
+L + ++ +NK G+T L AA G+ D+VQLL+ GA D + K
Sbjct: 1338 LLIGR-GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1386
Score = 45.1 bits (105), Expect = 5e-05
Identities = 26/67 (38%), Positives = 37/67 (55%), Gaps = 1/67 (1%)
Query: 104 KAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKG 163
K T L A +GGH IV++L ++N Q+ G+TAL A GY D+V++LL G
Sbjct: 299 KGDITPLMAAANGGHVKIVKLLLAH-KADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
Query: 164 ARTDLRN 170
A + N
Sbjct: 358 ASIEDHN 364
Score = 42.7 bits (99), Expect = 2e-04
Identities = 32/92 (34%), Positives = 51/92 (55%), Gaps = 4/92 (4%)
Query: 75 NPLHEAAKRGNLSWLRECLDNRVGVNG-LDKAGSTALYWACHGGHKDIVEMLFTQP-NIE 132
+PL AA G+ + ++ LD +N ++ +TAL AC G ++V +L + N+E
Sbjct: 1220 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1279
Query: 133 LNQQNKLGDTALHAAAWKGYADIVQLLLAKGA 164
+ K G T L AA GYA++ ++LL KGA
Sbjct: 1280 --HRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1309
Score = 42.0 bits (97), Expect = 4e-04
Identities = 28/91 (30%), Positives = 43/91 (47%), Gaps = 1/91 (1%)
Query: 93 LDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQ-PNIELNQQNKLGDTALHAAAWKG 151
LD + V K G T L A GG+ ++ +L + ++ DTAL AA KG
Sbjct: 1272 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1331
Query: 152 YADIVQLLLAKGARTDLRNIEKKLAFDMATN 182
+ +LL+ +GA D+RN + +A N
Sbjct: 1332 HYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1362
Score = 41.6 bits (96), Expect = 5e-04
Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 2/125 (1%)
Query: 67 AEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLF 126
A +S + L EA G+++ +R+ L VN + G + L AC G+ ++ ++L
Sbjct: 228 ANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 287
Query: 127 TQPNIELNQQNKLGD-TALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAAC 185
+ + + GD T L AAA G+ IV+LLLA A + ++ A A
Sbjct: 288 AM-HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGY 346
Query: 186 ASLLK 190
++K
Sbjct: 347 VDVVK 351
Score = 41.6 bits (96), Expect = 5e-04
Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 4/117 (3%)
Query: 69 QAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQ 128
+ + + L EA G++ R LD+ VN + + L A GGH ++ +L +
Sbjct: 430 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489
Query: 129 PNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAAC 185
L + N G T L AA +G+ ++V LLL +GA + + E + + A AC
Sbjct: 490 -GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQ---ETALTLAC 542
Score = 41.6 bits (96), Expect = 5e-04
Identities = 26/89 (29%), Positives = 47/89 (52%), Gaps = 1/89 (1%)
Query: 72 SIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNI 131
S D L AA +G+ + + ++ +K G+T L+ A +GGH D+V++L Q
Sbjct: 1319 SRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL-VQAGA 1377
Query: 132 ELNQQNKLGDTALHAAAWKGYADIVQLLL 160
+++ + T L AA KG+ +V+ L+
Sbjct: 1378 DVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
Score = 40.0 bits (92), Expect = 0.001
Identities = 26/99 (26%), Positives = 47/99 (47%)
Query: 70 AESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQP 129
A+S ++PL AA G++ ++ + ++ G T L A GH+++V +L Q
Sbjct: 464 ADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQG 523
Query: 130 NIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDL 168
Q + +TAL A G+ ++ L+ GA +L
Sbjct: 524 ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL 562
Score = 33.1 bits (74), Expect = 0.18
Identities = 28/97 (28%), Positives = 48/97 (49%), Gaps = 4/97 (4%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGL--DKAGSTALYWACHGGHKDIVEMLFTQPNIEL 133
PL AA G ++ ++ L+ +N K G + L A GH V++L + ++
Sbjct: 1186 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS-DI 1244
Query: 134 NQQNKLG-DTALHAAAWKGYADIVQLLLAKGARTDLR 169
N Q + +TAL A ++G ++V LLL + A + R
Sbjct: 1245 NAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHR 1281
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 60.1 bits (144), Expect = 1e-09
Identities = 43/136 (31%), Positives = 61/136 (44%), Gaps = 4/136 (2%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135
PL EAA+ G+L ++ L V+ G TAL +AC GH D+ ++L Q +L
Sbjct: 567 PLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL-QAGADLEH 625
Query: 136 QNKLGDTALHAAAWKGYADIVQLLLAKGA---RTDLRNIEKKLAFDMATNAACASLLKKK 192
+++ G T L AA G+ VQ L++KGA RT N L+ A L
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 193 QGTDAVRTLSNAEDYL 208
G D L + L
Sbjct: 686 HGADPTHRLKDGSTML 701
Score = 56.6 bits (135), Expect = 2e-08
Identities = 35/110 (31%), Positives = 57/110 (51%), Gaps = 4/110 (3%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135
PL AA G++ ++ L ++ VN G+TAL +AC GG+ D+V++L + +
Sbjct: 304 PLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL-ESGASIED 362
Query: 136 QNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAAC 185
N+ G T L A G+ ++ +LLL GA + + E K + A AC
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK---ESALTLAC 409
Score = 52.4 bits (124), Expect = 3e-07
Identities = 34/124 (27%), Positives = 55/124 (44%)
Query: 67 AEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLF 126
A+ + D L A G+ ++ L+ + DK G T L A GH +VE+L
Sbjct: 826 AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 885
Query: 127 TQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACA 186
Q + DT L A G ++V+LLLA+GA + RN+ +A +
Sbjct: 886 DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 945
Query: 187 SLLK 190
+++K
Sbjct: 946 NIIK 949
Score = 47.4 bits (111), Expect = 9e-06
Identities = 38/110 (34%), Positives = 53/110 (48%), Gaps = 3/110 (2%)
Query: 66 VAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNG--LDKAGSTALYWACHGGHKDIVE 123
V +A++ PL EAA G R LD VN + + TAL A GH E
Sbjct: 1027 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1086
Query: 124 MLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEK 173
+L + ++ +NK G+T L AA G+ D+VQLL+ GA D + K
Sbjct: 1087 LLIGR-GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1135
Score = 45.1 bits (105), Expect = 5e-05
Identities = 26/67 (38%), Positives = 37/67 (55%), Gaps = 1/67 (1%)
Query: 104 KAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKG 163
K T L A +GGH IV++L ++N Q+ G+TAL A GY D+V++LL G
Sbjct: 299 KGDITPLMAAANGGHVKIVKLLLAH-KADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
Query: 164 ARTDLRN 170
A + N
Sbjct: 358 ASIEDHN 364
Score = 42.7 bits (99), Expect = 2e-04
Identities = 32/92 (34%), Positives = 51/92 (55%), Gaps = 4/92 (4%)
Query: 75 NPLHEAAKRGNLSWLRECLDNRVGVNG-LDKAGSTALYWACHGGHKDIVEMLFTQP-NIE 132
+PL AA G+ + ++ LD +N ++ +TAL AC G ++V +L + N+E
Sbjct: 969 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1028
Query: 133 LNQQNKLGDTALHAAAWKGYADIVQLLLAKGA 164
+ K G T L AA GYA++ ++LL KGA
Sbjct: 1029 --HRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1058
Score = 42.0 bits (97), Expect = 4e-04
Identities = 28/91 (30%), Positives = 43/91 (47%), Gaps = 1/91 (1%)
Query: 93 LDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQ-PNIELNQQNKLGDTALHAAAWKG 151
LD + V K G T L A GG+ ++ +L + ++ DTAL AA KG
Sbjct: 1021 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1080
Query: 152 YADIVQLLLAKGARTDLRNIEKKLAFDMATN 182
+ +LL+ +GA D+RN + +A N
Sbjct: 1081 HYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1111
Score = 41.6 bits (96), Expect = 5e-04
Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 2/125 (1%)
Query: 67 AEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLF 126
A +S + L EA G+++ +R+ L VN + G + L AC G+ ++ ++L
Sbjct: 228 ANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 287
Query: 127 TQPNIELNQQNKLGD-TALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAAC 185
+ + + GD T L AAA G+ IV+LLLA A + ++ A A
Sbjct: 288 AM-HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGY 346
Query: 186 ASLLK 190
++K
Sbjct: 347 VDVVK 351
Score = 41.6 bits (96), Expect = 5e-04
Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 4/117 (3%)
Query: 69 QAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQ 128
+ + + L EA G++ R LD+ VN + + L A GGH ++ +L +
Sbjct: 430 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489
Query: 129 PNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAAC 185
L + N G T L AA +G+ ++V LLL +GA + + E + + A AC
Sbjct: 490 -GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQ---ETALTLAC 542
Score = 41.6 bits (96), Expect = 5e-04
Identities = 26/89 (29%), Positives = 47/89 (52%), Gaps = 1/89 (1%)
Query: 72 SIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNI 131
S D L AA +G+ + + ++ +K G+T L+ A +GGH D+V++L Q
Sbjct: 1068 SRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL-VQAGA 1126
Query: 132 ELNQQNKLGDTALHAAAWKGYADIVQLLL 160
+++ + T L AA KG+ +V+ L+
Sbjct: 1127 DVDAADNRKITPLMAAFRKGHVKVVRYLV 1155
Score = 40.0 bits (92), Expect = 0.001
Identities = 26/99 (26%), Positives = 47/99 (47%)
Query: 70 AESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQP 129
A+S ++PL AA G++ ++ + ++ G T L A GH+++V +L Q
Sbjct: 464 ADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQG 523
Query: 130 NIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDL 168
Q + +TAL A G+ ++ L+ GA +L
Sbjct: 524 ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL 562
Score = 33.1 bits (74), Expect = 0.18
Identities = 28/97 (28%), Positives = 48/97 (49%), Gaps = 4/97 (4%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGL--DKAGSTALYWACHGGHKDIVEMLFTQPNIEL 133
PL AA G ++ ++ L+ +N K G + L A GH V++L + ++
Sbjct: 935 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS-DI 993
Query: 134 NQQNKLG-DTALHAAAWKGYADIVQLLLAKGARTDLR 169
N Q + +TAL A ++G ++V LLL + A + R
Sbjct: 994 NAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHR 1030
>gi|14195601 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform b [Homo sapiens]
Length = 998
Score = 59.7 bits (143), Expect = 2e-09
Identities = 42/132 (31%), Positives = 65/132 (49%), Gaps = 4/132 (3%)
Query: 80 AAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKL 139
A G+ +R+ L +N ++ G TAL+ AC + D+V+ L + +NQQ+
Sbjct: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFL-VENRANVNQQDNE 123
Query: 140 GDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLL---KKKQGTD 196
G T LHAAA GY +I + + GA + N E ++ D+A A LL KKQG D
Sbjct: 124 GWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGID 183
Query: 197 AVRTLSNAEDYL 208
++ E +
Sbjct: 184 LEQSRKEEEQQM 195
Score = 45.1 bits (105), Expect = 5e-05
Identities = 32/92 (34%), Positives = 48/92 (52%), Gaps = 3/92 (3%)
Query: 104 KAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKG 163
++G+TAL+ A G+ +++ +L Q ELN Q+ G T LHAAA G + +L
Sbjct: 215 RSGATALHVAAAKGYSEVLRLLI-QAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEAL 273
Query: 164 ARTDLRNIEKKLAFDMATNAAC--ASLLKKKQ 193
D+RN + FD+A LL+KKQ
Sbjct: 274 CDMDIRNKLGQTPFDVADEGLVEHLELLQKKQ 305
Score = 35.8 bits (81), Expect = 0.028
Identities = 30/94 (31%), Positives = 45/94 (47%), Gaps = 2/94 (2%)
Query: 69 QAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQ 128
QA S LH AA +G LR + +N D G T L+ A H G K+ +L +
Sbjct: 213 QARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL-AE 271
Query: 129 PNIELNQQNKLGDTALHAAAWKGYADIVQLLLAK 162
+++ +NKLG T A +G + ++LL K
Sbjct: 272 ALCDMDIRNKLGQTPFDVAD-EGLVEHLELLQKK 304
Score = 35.0 bits (79), Expect = 0.048
Identities = 29/123 (23%), Positives = 50/123 (40%), Gaps = 26/123 (21%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135
PLH AA G L+ +++ V ++ G A KD++ + I+L Q
Sbjct: 127 PLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQ 186
Query: 136 QNK--------------------------LGDTALHAAAWKGYADIVQLLLAKGARTDLR 169
K G TALH AA KGY+++++LL+ G +++
Sbjct: 187 SRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQ 246
Query: 170 NIE 172
+ +
Sbjct: 247 DYD 249
>gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform a [Homo sapiens]
Length = 982
Score = 59.7 bits (143), Expect = 2e-09
Identities = 42/132 (31%), Positives = 65/132 (49%), Gaps = 4/132 (3%)
Query: 80 AAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKL 139
A G+ +R+ L +N ++ G TAL+ AC + D+V+ L + +NQQ+
Sbjct: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFL-VENRANVNQQDNE 123
Query: 140 GDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLL---KKKQGTD 196
G T LHAAA GY +I + + GA + N E ++ D+A A LL KKQG D
Sbjct: 124 GWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGID 183
Query: 197 AVRTLSNAEDYL 208
++ E +
Sbjct: 184 LEQSRKEEEQQM 195
Score = 45.1 bits (105), Expect = 5e-05
Identities = 32/92 (34%), Positives = 48/92 (52%), Gaps = 3/92 (3%)
Query: 104 KAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKG 163
++G+TAL+ A G+ +++ +L Q ELN Q+ G T LHAAA G + +L
Sbjct: 215 RSGATALHVAAAKGYSEVLRLLI-QAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEAL 273
Query: 164 ARTDLRNIEKKLAFDMATNAAC--ASLLKKKQ 193
D+RN + FD+A LL+KKQ
Sbjct: 274 CDMDIRNKLGQTPFDVADEGLVEHLELLQKKQ 305
Score = 35.8 bits (81), Expect = 0.028
Identities = 30/94 (31%), Positives = 45/94 (47%), Gaps = 2/94 (2%)
Query: 69 QAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQ 128
QA S LH AA +G LR + +N D G T L+ A H G K+ +L +
Sbjct: 213 QARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL-AE 271
Query: 129 PNIELNQQNKLGDTALHAAAWKGYADIVQLLLAK 162
+++ +NKLG T A +G + ++LL K
Sbjct: 272 ALCDMDIRNKLGQTPFDVAD-EGLVEHLELLQKK 304
Score = 35.0 bits (79), Expect = 0.048
Identities = 29/123 (23%), Positives = 50/123 (40%), Gaps = 26/123 (21%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135
PLH AA G L+ +++ V ++ G A KD++ + I+L Q
Sbjct: 127 PLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQ 186
Query: 136 QNK--------------------------LGDTALHAAAWKGYADIVQLLLAKGARTDLR 169
K G TALH AA KGY+++++LL+ G +++
Sbjct: 187 SRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQ 246
Query: 170 NIE 172
+ +
Sbjct: 247 DYD 249
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 59.7 bits (143), Expect = 2e-09
Identities = 39/113 (34%), Positives = 54/113 (47%), Gaps = 1/113 (0%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135
PLH AA G + L N V D G L+ AC GH ++V +L + N
Sbjct: 61 PLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRH-GADPNA 119
Query: 136 QNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASL 188
++ T LH AA KG D+ +LL GA +RN + + A D+A +A A L
Sbjct: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVL 172
Score = 58.9 bits (141), Expect = 3e-09
Identities = 41/114 (35%), Positives = 54/114 (47%), Gaps = 1/114 (0%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135
PLH AA NL L + VN DK G L+ A GH D+ +L N +N
Sbjct: 682 PLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKY-NACVNA 740
Query: 136 QNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLL 189
+K T LH AA KG + LLLA GA L+N E + D+ + ++LL
Sbjct: 741 TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 49.7 bits (117), Expect = 2e-06
Identities = 34/105 (32%), Positives = 50/105 (47%), Gaps = 1/105 (0%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135
PLH AA + ++ L + V+ DK L+ AC GH ++ E+L + +N
Sbjct: 214 PLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELL-VKHGACVNA 272
Query: 136 QNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMA 180
+ T LH AA K ++ LLL+ GA L N K A D+A
Sbjct: 273 MDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA 317
Score = 49.7 bits (117), Expect = 2e-06
Identities = 34/104 (32%), Positives = 50/104 (48%), Gaps = 1/104 (0%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135
PLH AA +S + L + V+ DK G L+ AC GH ++ E+L + +N
Sbjct: 529 PLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV-VNV 587
Query: 136 QNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDM 179
+ T LH AA KG +I +LLL GA +N + D+
Sbjct: 588 ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL 631
Score = 46.6 bits (109), Expect = 2e-05
Identities = 37/114 (32%), Positives = 56/114 (49%), Gaps = 4/114 (3%)
Query: 59 GLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAG--STALYWACHG 116
G ++ AE E L EA + G++ ++ + VN D AG ST L++A
Sbjct: 10 GAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEK-VNSRDTAGRKSTPLHFAAGF 68
Query: 117 GHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRN 170
G KD+VE L Q + ++ G LH A G+A++V LLL GA + R+
Sbjct: 69 GRKDVVEYLL-QNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARD 121
Score = 35.0 bits (79), Expect = 0.048
Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 17/124 (13%)
Query: 66 VAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEML 125
+ E+ + PLH A+++ + + + + VN LD G T+L+ A + GH +L
Sbjct: 393 INEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
Query: 126 FT---QPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKG-----ARTDLRNIEKKLAF 177
+ PNI Q G TAL + VQ LL +G + D + +E A
Sbjct: 453 LSYGCDPNIISLQ----GFTALQMG-----NENVQQLLQEGISLGNSEADRQLLEAAKAG 503
Query: 178 DMAT 181
D+ T
Sbjct: 504 DVET 507
Score = 33.5 bits (75), Expect = 0.14
Identities = 31/109 (28%), Positives = 43/109 (39%), Gaps = 20/109 (18%)
Query: 76 PLHEAAKRGNLS--------WLRECLDNRVGVNGLDKAGSTA------------LYWACH 115
PLHEAA +G + + N G LD A +A L +
Sbjct: 127 PLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESAR 186
Query: 116 GGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGA 164
G+++ + L T N+ + + T LH AA IVQLLL GA
Sbjct: 187 SGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGA 235
Score = 27.7 bits (60), Expect = 7.6
Identities = 27/119 (22%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 54 SKGRTGLIPSNYVAEQA--ESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALY 111
+K L P+ + E+ E + L +AA+ +++ +++ L + + TAL+
Sbjct: 310 NKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALH 369
Query: 112 WACHGGH---KDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTD 167
A + K I E+L + +N++ K T LH A+ K + D+V++++ A+ +
Sbjct: 370 CAAASPYPKRKQICELLLRK-GANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVN 427
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 59.7 bits (143), Expect = 2e-09
Identities = 38/91 (41%), Positives = 54/91 (59%), Gaps = 2/91 (2%)
Query: 80 AAKRGNLSWLRECLDN-RVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNK 138
AA+RGNL+ L+ L++ RV V+ D G+T L A + GH D V L Q ++N Q +
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQ-GADINLQRE 77
Query: 139 LGDTALHAAAWKGYADIVQLLLAKGARTDLR 169
G TAL AA +G+ D+V+ L GA T+ R
Sbjct: 78 SGTTALFFAAQQGHNDVVRFLFGFGASTEFR 108
Score = 51.6 bits (122), Expect = 5e-07
Identities = 39/120 (32%), Positives = 58/120 (48%), Gaps = 4/120 (3%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIV-EMLFTQPNIELN 134
PL A++ G+ +R L + G+TAL A + G+ D++ E+L P + +
Sbjct: 181 PLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL 240
Query: 135 QQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLKKKQG 194
K G +ALHAA G V LLL GA LRN +L ++ N LL+ K+G
Sbjct: 241 ---KNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLLRSKEG 297
Score = 48.5 bits (114), Expect = 4e-06
Identities = 36/102 (35%), Positives = 54/102 (52%), Gaps = 7/102 (6%)
Query: 80 AAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKL 139
AA G++ +RE + +N ++G+TAL++A GH D+V LF + K
Sbjct: 53 AAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGF-GASTEFRTKD 111
Query: 140 GDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMAT 181
G TAL AA+ G+ +V+ LL GA NI +L +D AT
Sbjct: 112 GGTALLAASQYGHMQVVETLLKHGA-----NIHDQL-YDGAT 147
Score = 47.8 bits (112), Expect = 7e-06
Identities = 35/99 (35%), Positives = 47/99 (47%), Gaps = 1/99 (1%)
Query: 69 QAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQ 128
Q ES L AA++G+ +R K G TAL A GH +VE L
Sbjct: 75 QRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKH 134
Query: 129 PNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTD 167
++ Q G TAL AA GY D+++LLLA GA+ +
Sbjct: 135 -GANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVN 172
Score = 46.2 bits (108), Expect = 2e-05
Identities = 27/112 (24%), Positives = 57/112 (50%), Gaps = 1/112 (0%)
Query: 80 AAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKL 139
A++ G++ + L + ++ G+TAL+ A GG+ D++ +L ++NQ +
Sbjct: 119 ASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLAS-GAKVNQPRQD 177
Query: 140 GDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLKK 191
G L A+ G++++V+++L +GA D + A A N ++K+
Sbjct: 178 GTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKE 229
>gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
Length = 777
Score = 59.3 bits (142), Expect = 2e-09
Identities = 41/113 (36%), Positives = 58/113 (51%), Gaps = 1/113 (0%)
Query: 77 LHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQ 136
LH A+ +G++ + L N N D AG T L+ AC+ GH +VE+L Q +N
Sbjct: 432 LHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLL-QHKALVNTT 490
Query: 137 NKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLL 189
D+ LH AA G+ DIV+LLL+ GA + NI D + + SLL
Sbjct: 491 GYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
Score = 34.7 bits (78), Expect = 0.062
Identities = 18/52 (34%), Positives = 27/52 (51%)
Query: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFT 127
PLHEA G+L + L ++ VN + L+ A GH DIV++L +
Sbjct: 464 PLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLS 515
>gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]
Length = 352
Score = 58.9 bits (141), Expect = 3e-09
Identities = 30/63 (47%), Positives = 37/63 (58%), Gaps = 1/63 (1%)
Query: 4 PPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGLIPS 63
P P V+ Q RALY FEP EL F+EGDII +T+ D NW++G G +G P
Sbjct: 283 PKPSGVQMDQ-PCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPI 341
Query: 64 NYV 66
NYV
Sbjct: 342 NYV 344
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,684,353
Number of Sequences: 37866
Number of extensions: 360704
Number of successful extensions: 3129
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 481
Number of HSP's successfully gapped in prelim test: 141
Number of HSP's that attempted gapping in prelim test: 798
Number of HSP's gapped (non-prelim): 1703
length of query: 214
length of database: 18,247,518
effective HSP length: 98
effective length of query: 116
effective length of database: 14,536,650
effective search space: 1686251400
effective search space used: 1686251400
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.