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Search of human proteins with 16554623
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16554623 WD repeat domain 10 isoform 2 [Homo sapiens]
(1241 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16554623 WD repeat domain 10 isoform 2 [Homo sapiens] 2529 0.0
gi|16554621 WD repeat domain 10 isoform 1 [Homo sapiens] 2504 0.0
gi|16554619 WD repeat domain 10 isoform 3 [Homo sapiens] 2362 0.0
gi|16554625 WD repeat domain 10 isoform 4 [Homo sapiens] 2208 0.0
gi|41146563 PREDICTED: hypothetical protein LOC653712 [Homo sapi... 184 3e-46
gi|169165594 PREDICTED: hypothetical LOC653712 [Homo sapiens] 183 8e-46
gi|88971034 PREDICTED: hypothetical LOC653712 [Homo sapiens] 183 8e-46
gi|56243599 WD repeat domain 35 isoform 2 [Homo sapiens] 64 7e-10
gi|55743161 WD repeat domain 35 isoform 1 [Homo sapiens] 64 7e-10
gi|32189425 WD repeat domain 69 [Homo sapiens] 63 2e-09
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 59 3e-08
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 59 3e-08
gi|16554629 WD repeat domain 5 [Homo sapiens] 58 6e-08
gi|16554627 WD repeat domain 5 [Homo sapiens] 58 6e-08
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 57 1e-07
gi|26665869 WD repeat domain 51B [Homo sapiens] 57 1e-07
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 56 2e-07
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ... 56 2e-07
gi|55743151 WD repeat domain 19 [Homo sapiens] 56 2e-07
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 55 3e-07
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 55 4e-07
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 55 4e-07
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 55 4e-07
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 55 4e-07
gi|113865883 WD repeat domain 38 [Homo sapiens] 55 4e-07
gi|23199987 WD repeat domain 5B [Homo sapiens] 55 5e-07
gi|46358428 selective LIM binding factor homolog [Homo sapiens] 54 9e-07
gi|21071067 TBP-associated factor 5 [Homo sapiens] 53 2e-06
gi|4757988 WD repeat domain 39 [Homo sapiens] 50 1e-05
gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1... 50 1e-05
>gi|16554623 WD repeat domain 10 isoform 2 [Homo sapiens]
Length = 1241
Score = 2529 bits (6556), Expect = 0.0
Identities = 1241/1241 (100%), Positives = 1241/1241 (100%)
Query: 1 MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA 60
MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA
Sbjct: 1 MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA 60
Query: 61 YAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWS 120
YAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWS
Sbjct: 61 YAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWS 120
Query: 121 PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIW 180
PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIW
Sbjct: 121 PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIW 180
Query: 181 SICWNPSSRWESFWMNRENEDAEDVIVNRYIQEIPSTLKSAVYSSQGSEAEEEEPEEEDD 240
SICWNPSSRWESFWMNRENEDAEDVIVNRYIQEIPSTLKSAVYSSQGSEAEEEEPEEEDD
Sbjct: 181 SICWNPSSRWESFWMNRENEDAEDVIVNRYIQEIPSTLKSAVYSSQGSEAEEEEPEEEDD 240
Query: 241 SPRDDNLEERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGS 300
SPRDDNLEERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGS
Sbjct: 241 SPRDDNLEERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGS 300
Query: 301 DKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYK 360
DKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYK
Sbjct: 301 DKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYK 360
Query: 361 DRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLS 420
DRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLS
Sbjct: 361 DRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLS 420
Query: 421 DMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIG 480
DMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIG
Sbjct: 421 DMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIG 480
Query: 481 GPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLV 540
GPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLV
Sbjct: 481 GPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLV 540
Query: 541 YDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGS 600
YDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGS
Sbjct: 541 YDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGS 600
Query: 601 KIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFE 660
KIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFE
Sbjct: 601 KIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFE 660
Query: 661 TAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHEN 720
TAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHEN
Sbjct: 661 TAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHEN 720
Query: 721 LALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKA 780
LALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKA
Sbjct: 721 LALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKA 780
Query: 781 IEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQL 840
IEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQL
Sbjct: 781 IEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQL 840
Query: 841 HVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQ 900
HVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQ
Sbjct: 841 HVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQ 900
Query: 901 LTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHR 960
LTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHR
Sbjct: 901 LTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHR 960
Query: 961 HTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYD 1020
HTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYD
Sbjct: 961 HTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYD 1020
Query: 1021 KLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQP 1080
KLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQP
Sbjct: 1021 KLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQP 1080
Query: 1081 FIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVET 1140
FIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVET
Sbjct: 1081 FIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVET 1140
Query: 1141 KDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLP 1200
KDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLP
Sbjct: 1141 KDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLP 1200
Query: 1201 DASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP 1241
DASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP
Sbjct: 1201 DASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP 1241
>gi|16554621 WD repeat domain 10 isoform 1 [Homo sapiens]
Length = 1292
Score = 2504 bits (6490), Expect = 0.0
Identities = 1240/1292 (95%), Positives = 1241/1292 (96%), Gaps = 51/1292 (3%)
Query: 1 MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA 60
MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA
Sbjct: 1 MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA 60
Query: 61 YAKDGKRFASGSADKSVIIWTSKLEGILKYT----------------------------- 91
YAKDGKRFASGSADKSVIIWTSKLEGILKYT
Sbjct: 61 YAKDGKRFASGSADKSVIIWTSKLEGILKYTSWSVMSSLHLHLPFLGLHKTVRVTATDKA 120
Query: 92 ----------------------HNDAIQCVSYNPITHQLASCSSSDFGLWSPEQKSVSKH 129
HNDAIQCVSYNPITHQLASCSSSDFGLWSPEQKSVSKH
Sbjct: 121 PKGQGGRIDCLRPSVQNQPGQKHNDAIQCVSYNPITHQLASCSSSDFGLWSPEQKSVSKH 180
Query: 130 KSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSSR 189
KSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSSR
Sbjct: 181 KSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSSR 240
Query: 190 WESFWMNRENEDAEDVIVNRYIQEIPSTLKSAVYSSQGSEAEEEEPEEEDDSPRDDNLEE 249
WESFWMNRENEDAEDVIVNRYIQEIPSTLKSAVYSSQGSEAEEEEPEEEDDSPRDDNLEE
Sbjct: 241 WESFWMNRENEDAEDVIVNRYIQEIPSTLKSAVYSSQGSEAEEEEPEEEDDSPRDDNLEE 300
Query: 250 RNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVSLFTK 309
RNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVSLFTK
Sbjct: 301 RNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVSLFTK 360
Query: 310 DGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSM 369
DGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSM
Sbjct: 361 DGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSM 420
Query: 370 TDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLSDMHYRVKEK 429
TDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLSDMHYRVKEK
Sbjct: 421 TDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLSDMHYRVKEK 480
Query: 430 IIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLL 489
IIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLL
Sbjct: 481 IIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLL 540
Query: 490 VGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTKELL 549
VGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTKELL
Sbjct: 541 VGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTKELL 600
Query: 550 FQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFS 609
FQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFS
Sbjct: 601 FQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFS 660
Query: 610 ISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFETAKKAFIRV 669
ISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFETAKKAFIRV
Sbjct: 661 ISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFETAKKAFIRV 720
Query: 670 QDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDL 729
QDLRYLELISSIEERKK+GETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDL
Sbjct: 721 QDLRYLELISSIEERKKQGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDL 780
Query: 730 CMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGW 789
CMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGW
Sbjct: 781 CMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGW 840
Query: 790 VDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDE 849
VDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDE
Sbjct: 841 VDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDE 900
Query: 850 AFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTNNAVAES 909
AFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTNNAVAES
Sbjct: 901 AFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTNNAVAES 960
Query: 910 RFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHRHTEDPFSVH 969
RFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHRHTEDPFSVH
Sbjct: 961 RFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHRHTEDPFSVH 1020
Query: 970 RPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYDKLRGLYIPA 1029
RPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYDKLRGLYIPA
Sbjct: 1021 RPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYDKLRGLYIPA 1080
Query: 1030 RFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYD 1089
RFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYD
Sbjct: 1081 RFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYD 1140
Query: 1090 VLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVETKDSIGDEDP 1149
VLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVETKDSIGDEDP
Sbjct: 1141 VLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVETKDSIGDEDP 1200
Query: 1150 FTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLPDASITMCPS 1209
FTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLPDASITMCPS
Sbjct: 1201 FTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLPDASITMCPS 1260
Query: 1210 CFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP 1241
CFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP
Sbjct: 1261 CFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP 1292
>gi|16554619 WD repeat domain 10 isoform 3 [Homo sapiens]
Length = 1182
Score = 2362 bits (6121), Expect = 0.0
Identities = 1175/1241 (94%), Positives = 1177/1241 (94%), Gaps = 59/1241 (4%)
Query: 1 MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA 60
MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA
Sbjct: 1 MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA 60
Query: 61 YAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWS 120
YAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWS
Sbjct: 61 YAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWS 120
Query: 121 PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIW 180
PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPI
Sbjct: 121 PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPI- 179
Query: 181 SICWNPSSRWESFWMNRENEDAEDVIVNRYIQEIPSTLKSAVYSSQGSEAEEEEPEEEDD 240
W W
Sbjct: 180 ---------WSICW---------------------------------------------- 184
Query: 241 SPRDDNLEERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGS 300
+ + EERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGS
Sbjct: 185 ---NPSREERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGS 241
Query: 301 DKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYK 360
DKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYK
Sbjct: 242 DKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYK 301
Query: 361 DRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLS 420
DRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLS
Sbjct: 302 DRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLS 361
Query: 421 DMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIG 480
DMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIG
Sbjct: 362 DMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIG 421
Query: 481 GPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLV 540
GPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLV
Sbjct: 422 GPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLV 481
Query: 541 YDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGS 600
YDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGS
Sbjct: 482 YDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGS 541
Query: 601 KIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFE 660
KIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFE
Sbjct: 542 KIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFE 601
Query: 661 TAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHEN 720
TAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHEN
Sbjct: 602 TAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHEN 661
Query: 721 LALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKA 780
LALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKA
Sbjct: 662 LALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKA 721
Query: 781 IEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQL 840
IEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQL
Sbjct: 722 IEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQL 781
Query: 841 HVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQ 900
HVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQ
Sbjct: 782 HVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQ 841
Query: 901 LTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHR 960
LTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHR
Sbjct: 842 LTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHR 901
Query: 961 HTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYD 1020
HTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYD
Sbjct: 902 HTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYD 961
Query: 1021 KLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQP 1080
KLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQP
Sbjct: 962 KLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQP 1021
Query: 1081 FIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVET 1140
FIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVET
Sbjct: 1022 FIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVET 1081
Query: 1141 KDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLP 1200
KDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLP
Sbjct: 1082 KDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLP 1141
Query: 1201 DASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP 1241
DASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP
Sbjct: 1142 DASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP 1182
>gi|16554625 WD repeat domain 10 isoform 4 [Homo sapiens]
Length = 1131
Score = 2208 bits (5722), Expect = 0.0
Identities = 1115/1242 (89%), Positives = 1120/1242 (90%), Gaps = 112/1242 (9%)
Query: 1 MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA 60
MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKG
Sbjct: 1 MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKG--------- 51
Query: 61 YAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWS 120
H D + CV+Y + GLWS
Sbjct: 52 -------------------------------HKDTVYCVAY------------AKDGLWS 68
Query: 121 PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIW 180
PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPI
Sbjct: 69 PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPI- 127
Query: 181 SICWNPSSRWESFWMNRENEDAEDVIVNRYIQEIPSTLKSAVYSSQGSEAEEEEPEEEDD 240
W W
Sbjct: 128 ---------WSICW---------------------------------------------- 132
Query: 241 SPRDDNLEERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGS 300
+ + EERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGS
Sbjct: 133 ---NPSREERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGS 189
Query: 301 DKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYK 360
DKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYK
Sbjct: 190 DKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYK 249
Query: 361 DRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLS 420
DRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLS
Sbjct: 250 DRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLS 309
Query: 421 DMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIG 480
DMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIG
Sbjct: 310 DMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIG 369
Query: 481 GPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLV 540
GPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLV
Sbjct: 370 GPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLV 429
Query: 541 YDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGS 600
YDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGS
Sbjct: 430 YDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGS 489
Query: 601 KIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFE 660
KIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFE
Sbjct: 490 KIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFE 549
Query: 661 TAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHEN 720
TAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHEN
Sbjct: 550 TAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHEN 609
Query: 721 LALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKA 780
LALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKA
Sbjct: 610 LALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKA 669
Query: 781 IEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQL 840
IEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQL
Sbjct: 670 IEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQL 729
Query: 841 HVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQ 900
HVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQ
Sbjct: 730 HVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQ 789
Query: 901 LTNNAVAESRFNDAAYYYWMLSMQCLDIAQ-DPAQKDTMLGKFYHFQRLAELYHGYHAIH 959
LTNNAVAESRFNDAAYYYWMLSMQCLDIAQ DPAQKDTMLGKFYHFQRLAELYHGYHAIH
Sbjct: 790 LTNNAVAESRFNDAAYYYWMLSMQCLDIAQADPAQKDTMLGKFYHFQRLAELYHGYHAIH 849
Query: 960 RHTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAY 1019
RHTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAY
Sbjct: 850 RHTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAY 909
Query: 1020 DKLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQ 1079
DKLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQ
Sbjct: 910 DKLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQ 969
Query: 1080 PFIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVE 1139
PFIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVE
Sbjct: 970 PFIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVE 1029
Query: 1140 TKDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLL 1199
TKDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLL
Sbjct: 1030 TKDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLL 1089
Query: 1200 PDASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP 1241
PDASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP
Sbjct: 1090 PDASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP 1131
>gi|41146563 PREDICTED: hypothetical protein LOC653712 [Homo
sapiens]
Length = 121
Score = 184 bits (468), Expect = 3e-46
Identities = 92/96 (95%), Positives = 92/96 (95%), Gaps = 1/96 (1%)
Query: 522 MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKAS 581
MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGG LNIKAS
Sbjct: 1 MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGNLNIKAS 60
Query: 582 TFPVHRQKLQGFVVGYNGSKIFCLHVFSISAVEVPQ 617
FPVH QKLQGFVVGYNGSKIFCLHVF ISAVEVPQ
Sbjct: 61 IFPVHWQKLQGFVVGYNGSKIFCLHVF-ISAVEVPQ 95
>gi|169165594 PREDICTED: hypothetical LOC653712 [Homo sapiens]
Length = 121
Score = 183 bits (465), Expect = 8e-46
Identities = 91/96 (94%), Positives = 92/96 (95%), Gaps = 1/96 (1%)
Query: 522 MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKAS 581
MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGG LNIKAS
Sbjct: 1 MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGNLNIKAS 60
Query: 582 TFPVHRQKLQGFVVGYNGSKIFCLHVFSISAVEVPQ 617
FPVH QKLQGFVVGYNGSKIFCLHVF ISA+EVPQ
Sbjct: 61 IFPVHWQKLQGFVVGYNGSKIFCLHVF-ISALEVPQ 95
>gi|88971034 PREDICTED: hypothetical LOC653712 [Homo sapiens]
Length = 121
Score = 183 bits (465), Expect = 8e-46
Identities = 91/96 (94%), Positives = 92/96 (95%), Gaps = 1/96 (1%)
Query: 522 MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKAS 581
MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGG LNIKAS
Sbjct: 1 MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGNLNIKAS 60
Query: 582 TFPVHRQKLQGFVVGYNGSKIFCLHVFSISAVEVPQ 617
FPVH QKLQGFVVGYNGSKIFCLHVF ISA+EVPQ
Sbjct: 61 IFPVHWQKLQGFVVGYNGSKIFCLHVF-ISALEVPQ 95
>gi|56243599 WD repeat domain 35 isoform 2 [Homo sapiens]
Length = 1170
Score = 64.3 bits (155), Expect = 7e-10
Identities = 90/446 (20%), Positives = 181/446 (40%), Gaps = 37/446 (8%)
Query: 488 LLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTK- 546
L+VG ++G I + + N+ I L ++ + +LA++D + +D+D +
Sbjct: 506 LIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARV 565
Query: 547 ----------ELL-FQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVV 595
ELL + + + W D+ + + + P + G++
Sbjct: 566 TDSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYIC 625
Query: 596 GYNGSKIFCLHVFSI-SAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTD--------- 645
+ +I + + I E P + + R L I +G+ D
Sbjct: 626 NFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHP 685
Query: 646 --WRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIEERKKRGE-TNNDLFLADVFSY 702
WR LA AL+ LD TA++AF+R +D + ++ + K+ G+ + + A+V Y
Sbjct: 686 RLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFV------KRLGKLLSESMKQAEVVGY 739
Query: 703 QGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFL--GSGDPKETKMLITKQA--DWA 758
G+F EA + Y +LA+ + L + L GSGD ++ + A D+
Sbjct: 740 FGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYF 799
Query: 759 RNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKL 818
+ ++ AV+ Y+ + E + L ++A L + + L A ++
Sbjct: 800 ADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPE-NHKLLPEIAQMFVRV 858
Query: 819 DSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFK-DDIYMPYAQWLAENDR 877
A +LK K+ V V +W++A L + H + + YA L E ++
Sbjct: 859 GMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNK 918
Query: 878 FEEAQKAFHKAGRQREAVQVLEQLTN 903
+A + + KA +A +++ ++ +
Sbjct: 919 TLDAIELYRKANYFFDAAKLMFKIAD 944
Score = 35.8 bits (81), Expect = 0.26
Identities = 27/143 (18%), Positives = 62/143 (43%), Gaps = 20/143 (13%)
Query: 41 SDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWT----SKLEGILKYTHNDAI 96
S+ ++ Q L+GH +V V + + ++ + + +I+W S +E ++ + +
Sbjct: 59 SNLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVV 118
Query: 97 QCVSYNPITHQLASC---------SSSDFGLWSPEQKSVSKHKSSSKIICCSWTNDGQYL 147
+ +S+N ++ S +W + K + ++ +W+ D + L
Sbjct: 119 RSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGI-------QLSHVTWSADSKVL 171
Query: 148 ALGMFNGIISIRNKNGEEKVKIE 170
GM NG I I + G +K++
Sbjct: 172 LFGMANGEIHIYDNQGNFMIKMK 194
>gi|55743161 WD repeat domain 35 isoform 1 [Homo sapiens]
Length = 1181
Score = 64.3 bits (155), Expect = 7e-10
Identities = 90/446 (20%), Positives = 181/446 (40%), Gaps = 37/446 (8%)
Query: 488 LLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTK- 546
L+VG ++G I + + N+ I L ++ + +LA++D + +D+D +
Sbjct: 517 LIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARV 576
Query: 547 ----------ELL-FQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVV 595
ELL + + + W D+ + + + P + G++
Sbjct: 577 TDSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYIC 636
Query: 596 GYNGSKIFCLHVFSI-SAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTD--------- 645
+ +I + + I E P + + R L I +G+ D
Sbjct: 637 NFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHP 696
Query: 646 --WRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIEERKKRGE-TNNDLFLADVFSY 702
WR LA AL+ LD TA++AF+R +D + ++ + K+ G+ + + A+V Y
Sbjct: 697 RLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFV------KRLGKLLSESMKQAEVVGY 750
Query: 703 QGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFL--GSGDPKETKMLITKQA--DWA 758
G+F EA + Y +LA+ + L + L GSGD ++ + A D+
Sbjct: 751 FGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYF 810
Query: 759 RNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKL 818
+ ++ AV+ Y+ + E + L ++A L + + L A ++
Sbjct: 811 ADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPE-NHKLLPEIAQMFVRV 869
Query: 819 DSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFK-DDIYMPYAQWLAENDR 877
A +LK K+ V V +W++A L + H + + YA L E ++
Sbjct: 870 GMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNK 929
Query: 878 FEEAQKAFHKAGRQREAVQVLEQLTN 903
+A + + KA +A +++ ++ +
Sbjct: 930 TLDAIELYRKANYFFDAAKLMFKIAD 955
Score = 35.8 bits (81), Expect = 0.26
Identities = 27/143 (18%), Positives = 62/143 (43%), Gaps = 20/143 (13%)
Query: 41 SDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWT----SKLEGILKYTHNDAI 96
S+ ++ Q L+GH +V V + + ++ + + +I+W S +E ++ + +
Sbjct: 59 SNLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVV 118
Query: 97 QCVSYNPITHQLASC---------SSSDFGLWSPEQKSVSKHKSSSKIICCSWTNDGQYL 147
+ +S+N ++ S +W + K + ++ +W+ D + L
Sbjct: 119 RSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGI-------QLSHVTWSADSKVL 171
Query: 148 ALGMFNGIISIRNKNGEEKVKIE 170
GM NG I I + G +K++
Sbjct: 172 LFGMANGEIHIYDNQGNFMIKMK 194
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 63.2 bits (152), Expect = 2e-09
Identities = 77/345 (22%), Positives = 145/345 (42%), Gaps = 34/345 (9%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKD-GKRFASGS 72
+ ++A G+ I + R ++DT+ G L L+GH++ VY +A+ G + A+GS
Sbjct: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154
Query: 73 ADKSVIIWTSKLEGILKYT---HNDAIQCVSYNPITHQLASCS-SSDFGLWSPE--QKSV 126
DK+ +W+ + G +T H I C+S+NP + +A+ S + LW + ++
Sbjct: 155 FDKTCKLWSVE-TGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVY 213
Query: 127 SKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNP 186
+ S++II S+ G + G F+ + + + + KV I G + I S +N
Sbjct: 214 TLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI--GHCAEISSASFN- 270
Query: 187 SSRWESFWMNRENEDAEDVIVNRYIQEIPSTLKSAVYSSQGSEAEEEEPEEEDDSPRDDN 246
W+ + + D + + + +TL DD D
Sbjct: 271 ---WDCSLILTGSMDKTCKLWDATNGKCVATLTG-----------------HDDEILDSC 310
Query: 247 LEERNDILAVADW-GQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVS 305
+ ++A A G F + K I K + IS+ +G ++L G SDK
Sbjct: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370
Query: 306 LF-TKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQ 349
++ + G L + +++C N V+ G +D T ++
Sbjct: 371 IWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 38.5 bits (88), Expect = 0.040
Identities = 35/151 (23%), Positives = 64/151 (42%), Gaps = 18/151 (11%)
Query: 13 HC--INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFA 69
HC I+ +F D + ++ + + ++D ++G + L GH D + + GK A
Sbjct: 260 HCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIA 319
Query: 70 SGSADKSVIIWT-------SKLEGILKYTHNDAIQCVSYNPI-THQLASCSSSDFGLWSP 121
+ SAD + I++ +KLEG H I +S+NP H L S +W
Sbjct: 320 TASADGTARIFSAATRKCIAKLEG-----HEGEISKISFNPQGNHLLTGSSDKTARIWDA 374
Query: 122 EQKSVSK--HKSSSKIICCSWTNDGQYLALG 150
+ + + +I C++ G + G
Sbjct: 375 QTGQCLQVLEGHTDEIFSCAFNYKGNIVITG 405
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 58.9 bits (141), Expect = 3e-08
Identities = 33/89 (37%), Positives = 51/89 (57%), Gaps = 3/89 (3%)
Query: 42 DGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEG-ILKYT-HNDAIQCV 99
D +L + KGH+D V CV ++ + K+ ASGS D +++W K + ++T H DA+ CV
Sbjct: 8 DPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCV 67
Query: 100 SYNPITHQLASCS-SSDFGLWSPEQKSVS 127
+++P H LAS S +W P K S
Sbjct: 68 NFSPSGHLLASGSRDKTVRIWVPNVKGES 96
Score = 56.6 bits (135), Expect = 1e-07
Identities = 27/72 (37%), Positives = 43/72 (59%), Gaps = 1/72 (1%)
Query: 15 INDIAFKPDGTQLILAAG-SRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
+N ++F P G LI A+ S L + D +G LL L GH+ VA+++ G+ FASG +
Sbjct: 232 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291
Query: 74 DKSVIIWTSKLE 85
D+ V++W S +
Sbjct: 292 DEQVMVWKSNFD 303
Score = 46.2 bits (108), Expect = 2e-04
Identities = 37/149 (24%), Positives = 68/149 (45%), Gaps = 12/149 (8%)
Query: 29 LAAGSR---LLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLE 85
LA+GS L+V+ + GHKD V CV ++ G ASGS DK+V IW ++
Sbjct: 34 LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVK 93
Query: 86 G--ILKYTHNDAIQCVSYNPITHQLASCS-SSDFGLWSPEQK----SVSKHKSSSKIICC 138
G + H ++ V + + S +W+ ++ S+S+H + + C
Sbjct: 94 GESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQH--INWVRCA 151
Query: 139 SWTNDGQYLALGMFNGIISIRNKNGEEKV 167
++ DG+ + + + + +K+ E V
Sbjct: 152 KFSPDGRLIVSASDDKTVKLWDKSSRECV 180
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 58.9 bits (141), Expect = 3e-08
Identities = 33/89 (37%), Positives = 51/89 (57%), Gaps = 3/89 (3%)
Query: 42 DGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEG-ILKYT-HNDAIQCV 99
D +L + KGH+D V CV ++ + K+ ASGS D +++W K + ++T H DA+ CV
Sbjct: 8 DPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCV 67
Query: 100 SYNPITHQLASCS-SSDFGLWSPEQKSVS 127
+++P H LAS S +W P K S
Sbjct: 68 NFSPSGHLLASGSRDKTVRIWVPNVKGES 96
Score = 56.6 bits (135), Expect = 1e-07
Identities = 27/72 (37%), Positives = 43/72 (59%), Gaps = 1/72 (1%)
Query: 15 INDIAFKPDGTQLILAAG-SRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
+N ++F P G LI A+ S L + D +G LL L GH+ VA+++ G+ FASG +
Sbjct: 232 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291
Query: 74 DKSVIIWTSKLE 85
D+ V++W S +
Sbjct: 292 DEQVMVWKSNFD 303
Score = 46.2 bits (108), Expect = 2e-04
Identities = 37/149 (24%), Positives = 68/149 (45%), Gaps = 12/149 (8%)
Query: 29 LAAGSR---LLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLE 85
LA+GS L+V+ + GHKD V CV ++ G ASGS DK+V IW ++
Sbjct: 34 LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVK 93
Query: 86 G--ILKYTHNDAIQCVSYNPITHQLASCS-SSDFGLWSPEQK----SVSKHKSSSKIICC 138
G + H ++ V + + S +W+ ++ S+S+H + + C
Sbjct: 94 GESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQH--INWVRCA 151
Query: 139 SWTNDGQYLALGMFNGIISIRNKNGEEKV 167
++ DG+ + + + + +K+ E V
Sbjct: 152 KFSPDGRLIVSASDDKTVKLWDKSSRECV 180
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 57.8 bits (138), Expect = 6e-08
Identities = 32/91 (35%), Positives = 48/91 (52%), Gaps = 3/91 (3%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
I+D+A+ D L+ A+ + L ++D S G L+ LKGH + V+C + SGS
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 74 DKSVIIWTSKLEGILKY--THNDAIQCVSYN 102
D+SV IW K LK H+D + V +N
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
Score = 50.4 bits (119), Expect = 1e-05
Identities = 35/152 (23%), Positives = 70/152 (46%), Gaps = 10/152 (6%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
++ + F P+G L ++ +L+ ++ DG + + GHK + VA++ D S S
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 74 DKSVIIWTSKLEGILKYT--HNDAIQCVSYNPITHQLASCS-SSDFGLWSPEQ----KSV 126
DK++ IW LK H++ + C ++NP ++ + S S +W + K++
Sbjct: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167
Query: 127 SKHKSSSKIICCSWTNDGQYLALGMFNGIISI 158
H S + + DG + ++G+ I
Sbjct: 168 PAH--SDPVSAVHFNRDGSLIVSSSYDGLCRI 197
Score = 45.4 bits (106), Expect = 3e-04
Identities = 29/104 (27%), Positives = 51/104 (49%), Gaps = 6/104 (5%)
Query: 15 INDIAFKPDGTQLILAA-GSRLLVYDTSDGTLLQPLKGHKDTVYCV---AYAKDGKRFAS 70
++ + F P+G ++ A + L ++D S G L+ GHK+ YC+ GK S
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276
Query: 71 GSADKSVIIWTSKLEGILK--YTHNDAIQCVSYNPITHQLASCS 112
GS D V IW + + I++ H D + + +P + +AS +
Sbjct: 277 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 320
Score = 39.7 bits (91), Expect = 0.018
Identities = 34/141 (24%), Positives = 61/141 (43%), Gaps = 9/141 (6%)
Query: 37 VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKY---THN 93
++D G L+ L H D V V + +DG S S D IW + LK N
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
Query: 94 DAIQCVSYNPI-THQLASCSSSDFGLWSPEQ----KSVSKHKSSSKIICCSWT-NDGQYL 147
+ V ++P + LA+ + LW + K+ + HK+ I +++ G+++
Sbjct: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274
Query: 148 ALGMFNGIISIRNKNGEEKVK 168
G + ++ I N +E V+
Sbjct: 275 VSGSEDNLVYIWNLQTKEIVQ 295
Score = 38.1 bits (87), Expect = 0.053
Identities = 31/118 (26%), Positives = 53/118 (44%), Gaps = 11/118 (9%)
Query: 49 LKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYT---HNDAIQCVSYNPIT 105
L GH V V ++ +G+ AS SADK + IW +G + T H I V+++ +
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIW-GAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 106 HQLASCS-SSDFGLWSPEQ----KSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISI 158
+ L S S +W K++ H S+ + CC++ + G F+ + I
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGH--SNYVFCCNFNPQSNLIVSGSFDESVRI 155
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 57.8 bits (138), Expect = 6e-08
Identities = 32/91 (35%), Positives = 48/91 (52%), Gaps = 3/91 (3%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
I+D+A+ D L+ A+ + L ++D S G L+ LKGH + V+C + SGS
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 74 DKSVIIWTSKLEGILKY--THNDAIQCVSYN 102
D+SV IW K LK H+D + V +N
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
Score = 50.4 bits (119), Expect = 1e-05
Identities = 35/152 (23%), Positives = 70/152 (46%), Gaps = 10/152 (6%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
++ + F P+G L ++ +L+ ++ DG + + GHK + VA++ D S S
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 74 DKSVIIWTSKLEGILKYT--HNDAIQCVSYNPITHQLASCS-SSDFGLWSPEQ----KSV 126
DK++ IW LK H++ + C ++NP ++ + S S +W + K++
Sbjct: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167
Query: 127 SKHKSSSKIICCSWTNDGQYLALGMFNGIISI 158
H S + + DG + ++G+ I
Sbjct: 168 PAH--SDPVSAVHFNRDGSLIVSSSYDGLCRI 197
Score = 45.4 bits (106), Expect = 3e-04
Identities = 29/104 (27%), Positives = 51/104 (49%), Gaps = 6/104 (5%)
Query: 15 INDIAFKPDGTQLILAA-GSRLLVYDTSDGTLLQPLKGHKDTVYCV---AYAKDGKRFAS 70
++ + F P+G ++ A + L ++D S G L+ GHK+ YC+ GK S
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276
Query: 71 GSADKSVIIWTSKLEGILK--YTHNDAIQCVSYNPITHQLASCS 112
GS D V IW + + I++ H D + + +P + +AS +
Sbjct: 277 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 320
Score = 39.7 bits (91), Expect = 0.018
Identities = 34/141 (24%), Positives = 61/141 (43%), Gaps = 9/141 (6%)
Query: 37 VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKY---THN 93
++D G L+ L H D V V + +DG S S D IW + LK N
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
Query: 94 DAIQCVSYNPI-THQLASCSSSDFGLWSPEQ----KSVSKHKSSSKIICCSWT-NDGQYL 147
+ V ++P + LA+ + LW + K+ + HK+ I +++ G+++
Sbjct: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274
Query: 148 ALGMFNGIISIRNKNGEEKVK 168
G + ++ I N +E V+
Sbjct: 275 VSGSEDNLVYIWNLQTKEIVQ 295
Score = 38.1 bits (87), Expect = 0.053
Identities = 31/118 (26%), Positives = 53/118 (44%), Gaps = 11/118 (9%)
Query: 49 LKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYT---HNDAIQCVSYNPIT 105
L GH V V ++ +G+ AS SADK + IW +G + T H I V+++ +
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIW-GAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 106 HQLASCS-SSDFGLWSPEQ----KSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISI 158
+ L S S +W K++ H S+ + CC++ + G F+ + I
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGH--SNYVFCCNFNPQSNLIVSGSFDESVRI 155
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 56.6 bits (135), Expect = 1e-07
Identities = 27/72 (37%), Positives = 43/72 (59%), Gaps = 1/72 (1%)
Query: 15 INDIAFKPDGTQLILAAG-SRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
+N ++F P G LI A+ S L + D +G LL L GH+ VA+++ G+ FASG +
Sbjct: 194 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 253
Query: 74 DKSVIIWTSKLE 85
D+ V++W S +
Sbjct: 254 DEQVMVWKSNFD 265
Score = 45.1 bits (105), Expect = 4e-04
Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 9/142 (6%)
Query: 33 SRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEG--ILKY 90
S L+V+ + GHKD V CV ++ G ASGS DK+V IW ++G +
Sbjct: 3 SCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR 62
Query: 91 THNDAIQCVSYNPITHQLASCS-SSDFGLWSPEQK----SVSKHKSSSKIICCSWTNDGQ 145
H ++ V + + S +W+ ++ S+S+H + + C ++ DG+
Sbjct: 63 AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQH--INWVRCAKFSPDGR 120
Query: 146 YLALGMFNGIISIRNKNGEEKV 167
+ + + + +K+ E V
Sbjct: 121 LIVSASDDKTVKLWDKSSRECV 142
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 56.6 bits (135), Expect = 1e-07
Identities = 27/72 (37%), Positives = 43/72 (59%), Gaps = 1/72 (1%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
+N I+F P G LI A+ L + D +G L+ L+GH V+ V+++K G+ FASG A
Sbjct: 231 VNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA 290
Query: 74 DKSVIIWTSKLE 85
D V++W + +
Sbjct: 291 DTQVLLWRTNFD 302
Score = 46.2 bits (108), Expect = 2e-04
Identities = 33/114 (28%), Positives = 59/114 (51%), Gaps = 5/114 (4%)
Query: 40 TSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEG-ILKYT-HNDAIQ 97
T D L + KGHK + + + +GK+ A+ S D +++W K +Y H D +
Sbjct: 5 TEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVT 64
Query: 98 CVSYNPITHQLASCS-SSDFGLWSPEQK-SVSKHKS-SSKIICCSWTNDGQYLA 148
V ++P + LAS S LW P+++ S+ K+ ++ + ++ DGQ+LA
Sbjct: 65 SVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLA 118
Score = 41.6 bits (96), Expect = 0.005
Identities = 36/150 (24%), Positives = 62/150 (41%), Gaps = 6/150 (4%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
+ + F DG L A+ + + V+ L L H V C ++ DG+ S S
Sbjct: 105 VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSE 164
Query: 74 DKSVIIW-TSKLEGILKYTHNDAI-QCVSYNPITHQLASCSSSD-FGLWSPEQKSVSKHK 130
DK++ IW T+ + + ++ + V +NP +AS S +W + +H
Sbjct: 165 DKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHY 224
Query: 131 S--SSKIICCSWTNDGQYLALGMFNGIISI 158
S + C S+ G YL +G + I
Sbjct: 225 QVHSGGVNCISFHPSGNYLITASSDGTLKI 254
Score = 40.0 bits (92), Expect = 0.014
Identities = 32/139 (23%), Positives = 60/139 (43%), Gaps = 6/139 (4%)
Query: 15 INDIAFKPDGTQLILAAGSR-LLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
I + P+G QL A+ L++++ GHKD V V ++ G AS S
Sbjct: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
Query: 74 DKSVIIWTSKLEGILK--YTHNDAIQCVSYNPITHQLASCS-SSDFGLWSPEQKS--VSK 128
D++V +W G H ++ V ++ LA+ S +WS ++ S
Sbjct: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
Query: 129 HKSSSKIICCSWTNDGQYL 147
++ + + C ++ DG+ +
Sbjct: 141 YRHTHWVRCAKFSPDGRLI 159
>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
Length = 421
Score = 56.2 bits (134), Expect = 2e-07
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 18/124 (14%)
Query: 15 INDIAFKPDGTQLILAAGSR---LLVYDTSD-GTLLQPLKGHKDTVYCVAYAKDGKRFAS 70
+ D+ F PDG+ LIL + SR L V+D D G +++ L+GH++ VY A++ D S
Sbjct: 173 VRDLTFAPDGS-LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCS 231
Query: 71 GSADKSVIIWT-------SKLEGILKYTHNDAIQCVSYNPITHQLASCS-SSDFGLWSPE 122
A K+V +W KLEG H+D + C ++P LA+ S + +W P
Sbjct: 232 VGASKAVFLWNMDKYTMIRKLEG----HHHDVVAC-DFSPDGALLATASYDTRVYIWDPH 286
Query: 123 QKSV 126
+
Sbjct: 287 NGDI 290
Score = 48.5 bits (114), Expect = 4e-05
Identities = 39/157 (24%), Positives = 73/157 (46%), Gaps = 12/157 (7%)
Query: 9 DKAEHCINDI--AFKPDGTQLILAAG---SRLLVYDTSDGTLLQPLKGHKDTVYCVAYAK 63
+K C+N F+ QL+LA G R+ ++D G LL L H + V + +A
Sbjct: 121 EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP 180
Query: 64 DGKR-FASGSADKSVIIWTSKLEGILKYT---HNDAIQCVSYNPITHQLASCSSSD-FGL 118
DG S S DK++ +W K +G + H + + +++P + L S +S L
Sbjct: 181 DGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL 240
Query: 119 WSPEQKSVSKHKSS--SKIICCSWTNDGQYLALGMFN 153
W+ ++ ++ + ++ C ++ DG LA ++
Sbjct: 241 WNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYD 277
>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
sapiens]
Length = 275
Score = 56.2 bits (134), Expect = 2e-07
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 18/124 (14%)
Query: 15 INDIAFKPDGTQLILAAGSR---LLVYDTSD-GTLLQPLKGHKDTVYCVAYAKDGKRFAS 70
+ D+ F PDG+ LIL + SR L V+D D G +++ L+GH++ VY A++ D S
Sbjct: 27 VRDLTFAPDGS-LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCS 85
Query: 71 GSADKSVIIWT-------SKLEGILKYTHNDAIQCVSYNPITHQLASCS-SSDFGLWSPE 122
A K+V +W KLEG H+D + C ++P LA+ S + +W P
Sbjct: 86 VGASKAVFLWNMDKYTMIRKLEG----HHHDVVAC-DFSPDGALLATASYDTRVYIWDPH 140
Query: 123 QKSV 126
+
Sbjct: 141 NGDI 144
>gi|55743151 WD repeat domain 19 [Homo sapiens]
Length = 1342
Score = 56.2 bits (134), Expect = 2e-07
Identities = 132/670 (19%), Positives = 256/670 (38%), Gaps = 85/670 (12%)
Query: 309 KDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDS 368
KD + + E+N + T D + + Q G++ + + R AY S
Sbjct: 307 KDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTRIAYLTS 366
Query: 369 MTDVIVQHLIT-EQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYS---EDLSDMHY 424
+ +V V + + E + + +A+ LA+ + + Y L + L DM Y
Sbjct: 367 LLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKKLKDMEY 426
Query: 425 RVKEKII--------KKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYI 476
I FE + + IL ++ + F V ++
Sbjct: 427 LGTVASICLHSDYAAALFEGKVQLHLIESEILDAQEERETRLFPAVDDK----------C 476
Query: 477 KVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDEND 536
+++ + L+ G G + ++++ + + +V+ + + +L +DE
Sbjct: 477 RILCHALTSDFLIYGTDTGVVQYFYIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKS 536
Query: 537 TCLVY---DIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGF 593
VY + T E+ P V W D F Y + K T+ H+ +QG
Sbjct: 537 DGFVYCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIA--YDDDKVYTYVFHKDTIQGA 594
Query: 594 VVGYNGS---------------KIFC-------------LHVF--SISAVEVPQSAPMY- 622
V GS ++ C H F ++ + PM
Sbjct: 595 KVILAGSTKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTHGFLSNLKDTGPDELRPMLA 654
Query: 623 QYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIE 682
Q L K F +A+++ + + W ELA L ++ E A + + R+ ++ ++ S+E
Sbjct: 655 QNLMLKRFSDAWEMCRILNDEAAWNELARACLHHMEVEFAIRVYRRIGNVG---IVMSLE 711
Query: 683 ERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSG 742
+ K G + +L + + ++ A LY S ALEM DL ++ A
Sbjct: 712 QIK--GIEDYNLLAGHLAMFTNDYNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHL 769
Query: 743 DPKETKMLITK---QADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLI---DI 796
P + + + Q ++A + A E I+ G++ + E C G M I DI
Sbjct: 770 APDQIPFISKEYAIQLEFAGDYVNALAHYEKGIT-GDNKEHDEACLA-GVAQMSIRMGDI 827
Query: 797 ARKLDKAEREPLLL----CATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFA 852
R +++A + P + C L+ + AA+ Y K +++ ++ W +
Sbjct: 828 RRGVNQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAK--- 884
Query: 853 LGEKHPEFKDD-IYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQV-LEQLTN-----NA 905
+G+ P I++ YA+ + R++EA A+ A + + +++ L+ L N N
Sbjct: 885 VGDLLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNI 944
Query: 906 VAESRFNDAA 915
V E++ D A
Sbjct: 945 VRETQSLDGA 954
Score = 38.5 bits (88), Expect = 0.040
Identities = 46/204 (22%), Positives = 83/204 (40%), Gaps = 29/204 (14%)
Query: 705 KFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEP 764
+F EAA+LY++ + + A +Y + D L + + K + KE
Sbjct: 855 QFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQYAKAKEADGRYKE- 913
Query: 765 KAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYA 824
AV Y +A + I I DH L+ E+ ++ T + LD
Sbjct: 914 --AVVAYENAKQWQSVIRIYLDH------------LNNPEKAVNIVRET--QSLDGAKMV 957
Query: 825 AETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFK------------DDIYMPYAQWL 872
A +L++GD S +Q V ++ +EAF L ++H + + ++ Y A +
Sbjct: 958 ARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADIIGSEDTTNEDYQSIALYF 1017
Query: 873 AENDRFEEAQKAFHKAGRQREAVQ 896
R+ +A K F G+ A++
Sbjct: 1018 EGEKRYLQAGKFFLLCGQYSRALK 1041
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 55.5 bits (132), Expect = 3e-07
Identities = 49/190 (25%), Positives = 89/190 (46%), Gaps = 18/190 (9%)
Query: 13 HCINDIAFKPDGTQLILAAG--SRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFAS 70
H ++D+ DG Q L+ L ++D + GT + GH V VA++ D ++ S
Sbjct: 64 HFVSDVVISSDG-QFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122
Query: 71 GSADKSVIIWTSKLEGILKYT-----HNDAIQCVSYNPITHQ--LASCSSSDF-GLWS-P 121
GS DK++ +W + G+ KYT H++ + CV ++P + + SC +W+
Sbjct: 123 GSRDKTIKLWNTL--GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180
Query: 122 EQKSVSKHKSSSKII-CCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIW 180
K + H + + + + DG A G +G + + N E K GG + I
Sbjct: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN-EGKHLYTLDGGDI--IN 237
Query: 181 SICWNPSSRW 190
++C++P+ W
Sbjct: 238 ALCFSPNRYW 247
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 55.1 bits (131), Expect = 4e-07
Identities = 42/148 (28%), Positives = 69/148 (46%), Gaps = 10/148 (6%)
Query: 20 FKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVI 78
F DG ++ + L V+ G L +K H+D V C A++ D + A+ S DK V
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 79 IWTSKLEGILKYT---HNDAIQCVSY-NPITHQLASCSSSD--FGLWSPEQKSV--SKHK 130
IW S + G L +T H++ + C + N H L + SSD LW QK +
Sbjct: 683 IWNS-MTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFG 741
Query: 131 SSSKIICCSWTNDGQYLALGMFNGIISI 158
++ + C ++ D + LA +G + +
Sbjct: 742 HTNSVNHCRFSPDDKLLASCSADGTLKL 769
Score = 48.1 bits (113), Expect = 5e-05
Identities = 28/106 (26%), Positives = 57/106 (53%), Gaps = 5/106 (4%)
Query: 49 LKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKL-EGILKY-THNDAIQCVSYNPITH 106
++ H D VY +++DG+R AS ADK++ ++ ++ E +L+ H D + C +++
Sbjct: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670
Query: 107 QLASCS-SSDFGLWSPEQKSV--SKHKSSSKIICCSWTNDGQYLAL 149
+A+CS +W+ + + + S ++ CC +TN +L L
Sbjct: 671 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLL 716
Score = 48.1 bits (113), Expect = 5e-05
Identities = 34/157 (21%), Positives = 72/157 (45%), Gaps = 12/157 (7%)
Query: 8 RDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKR 67
++ E + ++ DG ++++AA +++ +++T + + +GH V+ V ++ DG
Sbjct: 794 QEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 853
Query: 68 FASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQ------LASCSSSDFGLWSP 121
F + S D+++ +W +K K N A+ + Q LA L +
Sbjct: 854 FLTSSDDQTIRLWETK-----KVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 908
Query: 122 EQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISI 158
+ + + +++ CC + QY+A G NG I I
Sbjct: 909 RTGQID-YLTEAQVSCCCLSPHLQYIAFGDENGAIEI 944
Score = 34.7 bits (78), Expect = 0.58
Identities = 41/183 (22%), Positives = 73/183 (39%), Gaps = 34/183 (18%)
Query: 9 DKAEHCINDIAFKPDGTQLILAAGSR---LLVYDTSDGTLLQPLKGHKDTVYCVAYAKDG 65
D+ +N F L+LA GS L ++D + + GH ++V ++ D
Sbjct: 696 DEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDD 755
Query: 66 KRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWSPEQKS 125
K AS SAD ++ +W DA ++ S + F L +
Sbjct: 756 KLLASCSADGTLKLW-------------DATS-------ANERKSINVKQFFL------N 789
Query: 126 VSKHKSSSKII--CCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSIC 183
+ + ++I CCSW+ DG + + N I N + + K+ G LS + +
Sbjct: 790 LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFL---WNTDSRSKVADCRGHLSWVHGVM 846
Query: 184 WNP 186
++P
Sbjct: 847 FSP 849
Score = 31.2 bits (69), Expect = 6.4
Identities = 29/118 (24%), Positives = 49/118 (41%), Gaps = 11/118 (9%)
Query: 4 VLTWRDKAEHCINDIAFKPDGTQLILAAGSRLL---------VYDTSDGTLLQPLKGHKD 54
+ W + + CI + L SRLL V++ G + H+
Sbjct: 984 IQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQG 1043
Query: 55 TVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYT--HNDAIQCVSYNPITHQLAS 110
TV + D +F+S SADK+ IW+ L L HN ++C +++ + LA+
Sbjct: 1044 TVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1101
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 55.1 bits (131), Expect = 4e-07
Identities = 42/148 (28%), Positives = 69/148 (46%), Gaps = 10/148 (6%)
Query: 20 FKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVI 78
F DG ++ + L V+ G L +K H+D V C A++ D + A+ S DK V
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 79 IWTSKLEGILKYT---HNDAIQCVSY-NPITHQLASCSSSD--FGLWSPEQKSV--SKHK 130
IW S + G L +T H++ + C + N H L + SSD LW QK +
Sbjct: 683 IWNS-MTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFG 741
Query: 131 SSSKIICCSWTNDGQYLALGMFNGIISI 158
++ + C ++ D + LA +G + +
Sbjct: 742 HTNSVNHCRFSPDDKLLASCSADGTLKL 769
Score = 48.1 bits (113), Expect = 5e-05
Identities = 28/106 (26%), Positives = 57/106 (53%), Gaps = 5/106 (4%)
Query: 49 LKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKL-EGILKY-THNDAIQCVSYNPITH 106
++ H D VY +++DG+R AS ADK++ ++ ++ E +L+ H D + C +++
Sbjct: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670
Query: 107 QLASCS-SSDFGLWSPEQKSV--SKHKSSSKIICCSWTNDGQYLAL 149
+A+CS +W+ + + + S ++ CC +TN +L L
Sbjct: 671 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLL 716
Score = 37.0 bits (84), Expect = 0.12
Identities = 32/146 (21%), Positives = 61/146 (41%), Gaps = 13/146 (8%)
Query: 20 FKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVI 78
F P ++A + +++T + + +GH V+ V ++ DG F + S D+++
Sbjct: 848 FSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIR 907
Query: 79 IWTSKLEGILKYTHNDAIQCVSYNPITHQ------LASCSSSDFGLWSPEQKSVSKHKSS 132
+W +K K N A+ + Q LA L + + + +
Sbjct: 908 LWETK-----KVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID-YLTE 961
Query: 133 SKIICCSWTNDGQYLALGMFNGIISI 158
+++ CC + QY+A G NG I I
Sbjct: 962 AQVSCCCLSPHLQYIAFGDENGAIEI 987
Score = 31.6 bits (70), Expect = 4.9
Identities = 21/75 (28%), Positives = 35/75 (46%), Gaps = 3/75 (4%)
Query: 9 DKAEHCINDIAFKPDGTQLILAAGSR---LLVYDTSDGTLLQPLKGHKDTVYCVAYAKDG 65
D+ +N F L+LA GS L ++D + + GH ++V ++ D
Sbjct: 696 DEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDD 755
Query: 66 KRFASGSADKSVIIW 80
K AS SAD ++ +W
Sbjct: 756 KLLASCSADGTLKLW 770
Score = 31.2 bits (69), Expect = 6.4
Identities = 29/118 (24%), Positives = 49/118 (41%), Gaps = 11/118 (9%)
Query: 4 VLTWRDKAEHCINDIAFKPDGTQLILAAGSRLL---------VYDTSDGTLLQPLKGHKD 54
+ W + + CI + L SRLL V++ G + H+
Sbjct: 1027 IQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQG 1086
Query: 55 TVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYT--HNDAIQCVSYNPITHQLAS 110
TV + D +F+S SADK+ IW+ L L HN ++C +++ + LA+
Sbjct: 1087 TVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1144
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 55.1 bits (131), Expect = 4e-07
Identities = 42/148 (28%), Positives = 69/148 (46%), Gaps = 10/148 (6%)
Query: 20 FKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVI 78
F DG ++ + L V+ G L +K H+D V C A++ D + A+ S DK V
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
Query: 79 IWTSKLEGILKYT---HNDAIQCVSY-NPITHQLASCSSSD--FGLWSPEQKSV--SKHK 130
IW S + G L +T H++ + C + N H L + SSD LW QK +
Sbjct: 672 IWNS-MTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFG 730
Query: 131 SSSKIICCSWTNDGQYLALGMFNGIISI 158
++ + C ++ D + LA +G + +
Sbjct: 731 HTNSVNHCRFSPDDKLLASCSADGTLKL 758
Score = 48.1 bits (113), Expect = 5e-05
Identities = 28/106 (26%), Positives = 57/106 (53%), Gaps = 5/106 (4%)
Query: 49 LKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKL-EGILKY-THNDAIQCVSYNPITH 106
++ H D VY +++DG+R AS ADK++ ++ ++ E +L+ H D + C +++
Sbjct: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
Query: 107 QLASCS-SSDFGLWSPEQKSV--SKHKSSSKIICCSWTNDGQYLAL 149
+A+CS +W+ + + + S ++ CC +TN +L L
Sbjct: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLL 705
Score = 48.1 bits (113), Expect = 5e-05
Identities = 34/157 (21%), Positives = 72/157 (45%), Gaps = 12/157 (7%)
Query: 8 RDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKR 67
++ E + ++ DG ++++AA +++ +++T + + +GH V+ V ++ DG
Sbjct: 783 QEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 842
Query: 68 FASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQ------LASCSSSDFGLWSP 121
F + S D+++ +W +K K N A+ + Q LA L +
Sbjct: 843 FLTSSDDQTIRLWETK-----KVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 897
Query: 122 EQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISI 158
+ + + +++ CC + QY+A G NG I I
Sbjct: 898 RTGQID-YLTEAQVSCCCLSPHLQYIAFGDENGAIEI 933
Score = 34.7 bits (78), Expect = 0.58
Identities = 41/183 (22%), Positives = 73/183 (39%), Gaps = 34/183 (18%)
Query: 9 DKAEHCINDIAFKPDGTQLILAAGSR---LLVYDTSDGTLLQPLKGHKDTVYCVAYAKDG 65
D+ +N F L+LA GS L ++D + + GH ++V ++ D
Sbjct: 685 DEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDD 744
Query: 66 KRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWSPEQKS 125
K AS SAD ++ +W DA ++ S + F L +
Sbjct: 745 KLLASCSADGTLKLW-------------DATS-------ANERKSINVKQFFL------N 778
Query: 126 VSKHKSSSKII--CCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSIC 183
+ + ++I CCSW+ DG + + N I N + + K+ G LS + +
Sbjct: 779 LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFL---WNTDSRSKVADCRGHLSWVHGVM 835
Query: 184 WNP 186
++P
Sbjct: 836 FSP 838
Score = 31.2 bits (69), Expect = 6.4
Identities = 29/118 (24%), Positives = 49/118 (41%), Gaps = 11/118 (9%)
Query: 4 VLTWRDKAEHCINDIAFKPDGTQLILAAGSRLL---------VYDTSDGTLLQPLKGHKD 54
+ W + + CI + L SRLL V++ G + H+
Sbjct: 973 IQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQG 1032
Query: 55 TVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYT--HNDAIQCVSYNPITHQLAS 110
TV + D +F+S SADK+ IW+ L L HN ++C +++ + LA+
Sbjct: 1033 TVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1090
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 55.1 bits (131), Expect = 4e-07
Identities = 42/148 (28%), Positives = 69/148 (46%), Gaps = 10/148 (6%)
Query: 20 FKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVI 78
F DG ++ + L V+ G L +K H+D V C A++ D + A+ S DK V
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
Query: 79 IWTSKLEGILKYT---HNDAIQCVSY-NPITHQLASCSSSD--FGLWSPEQKSV--SKHK 130
IW S + G L +T H++ + C + N H L + SSD LW QK +
Sbjct: 672 IWNS-MTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFG 730
Query: 131 SSSKIICCSWTNDGQYLALGMFNGIISI 158
++ + C ++ D + LA +G + +
Sbjct: 731 HTNSVNHCRFSPDDKLLASCSADGTLKL 758
Score = 48.1 bits (113), Expect = 5e-05
Identities = 28/106 (26%), Positives = 57/106 (53%), Gaps = 5/106 (4%)
Query: 49 LKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKL-EGILKY-THNDAIQCVSYNPITH 106
++ H D VY +++DG+R AS ADK++ ++ ++ E +L+ H D + C +++
Sbjct: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
Query: 107 QLASCS-SSDFGLWSPEQKSV--SKHKSSSKIICCSWTNDGQYLAL 149
+A+CS +W+ + + + S ++ CC +TN +L L
Sbjct: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLL 705
Score = 37.0 bits (84), Expect = 0.12
Identities = 32/146 (21%), Positives = 61/146 (41%), Gaps = 13/146 (8%)
Query: 20 FKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVI 78
F P ++A + +++T + + +GH V+ V ++ DG F + S D+++
Sbjct: 837 FSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIR 896
Query: 79 IWTSKLEGILKYTHNDAIQCVSYNPITHQ------LASCSSSDFGLWSPEQKSVSKHKSS 132
+W +K K N A+ + Q LA L + + + +
Sbjct: 897 LWETK-----KVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID-YLTE 950
Query: 133 SKIICCSWTNDGQYLALGMFNGIISI 158
+++ CC + QY+A G NG I I
Sbjct: 951 AQVSCCCLSPHLQYIAFGDENGAIEI 976
Score = 31.6 bits (70), Expect = 4.9
Identities = 21/75 (28%), Positives = 35/75 (46%), Gaps = 3/75 (4%)
Query: 9 DKAEHCINDIAFKPDGTQLILAAGSR---LLVYDTSDGTLLQPLKGHKDTVYCVAYAKDG 65
D+ +N F L+LA GS L ++D + + GH ++V ++ D
Sbjct: 685 DEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDD 744
Query: 66 KRFASGSADKSVIIW 80
K AS SAD ++ +W
Sbjct: 745 KLLASCSADGTLKLW 759
Score = 31.2 bits (69), Expect = 6.4
Identities = 29/118 (24%), Positives = 49/118 (41%), Gaps = 11/118 (9%)
Query: 4 VLTWRDKAEHCINDIAFKPDGTQLILAAGSRLL---------VYDTSDGTLLQPLKGHKD 54
+ W + + CI + L SRLL V++ G + H+
Sbjct: 1016 IQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQG 1075
Query: 55 TVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYT--HNDAIQCVSYNPITHQLAS 110
TV + D +F+S SADK+ IW+ L L HN ++C +++ + LA+
Sbjct: 1076 TVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1133
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 55.1 bits (131), Expect = 4e-07
Identities = 47/181 (25%), Positives = 88/181 (48%), Gaps = 14/181 (7%)
Query: 20 FKPDGTQLILAA-GSRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVI 78
F PDG A+ + ++D + L+ LKGH+ +V V+++ D ++ ASG DK V+
Sbjct: 71 FSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVM 130
Query: 79 IWTSKLEGILKYT--HNDAIQCVSYNPITHQLASCS-SSDFGLW-----SPEQKSVSKHK 130
+W + +L+ H D+IQ ++P + LA+ S S +W +P +
Sbjct: 131 LWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEG 190
Query: 131 SSSKIICCSWTNDGQYLALGMFNGIISI-RNKNGEEKVKIERPGGSLSPIWSICWNPSSR 189
S+ I C ++ G LA G ++ I I + ++++ G ++ + SI ++P
Sbjct: 191 HSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLK---GHVTWVKSIAFSPDEL 246
Query: 190 W 190
W
Sbjct: 247 W 247
Score = 54.7 bits (130), Expect = 5e-07
Identities = 38/101 (37%), Positives = 54/101 (53%), Gaps = 7/101 (6%)
Query: 15 INDIAFKPDGTQLILAAGSRLLVY--DTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGS 72
+N AF PDG Q++L VY +T G LL L GH V ++ DG FAS S
Sbjct: 24 VNSSAFSPDG-QMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASAS 82
Query: 73 ADKSVIIW---TSKLEGILKYTHNDAIQCVSYNPITHQLAS 110
D +V +W +K +LK H +++ VS++P + QLAS
Sbjct: 83 CDCTVRLWDVARAKCLRVLK-GHQRSVETVSFSPDSRQLAS 122
Score = 45.4 bits (106), Expect = 3e-04
Identities = 25/63 (39%), Positives = 36/63 (57%), Gaps = 1/63 (1%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
+ IAF PD L A SR++ V+D + G L+ LKG D + A+ DGK SG+A
Sbjct: 236 VKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAA 295
Query: 74 DKS 76
D++
Sbjct: 296 DQT 298
Score = 31.2 bits (69), Expect = 6.4
Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 10/78 (12%)
Query: 28 ILAAGS---RLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIW---T 81
+LA+GS + ++ + +LL LKGH V +A++ D AS + V +W T
Sbjct: 205 LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNT 264
Query: 82 SK----LEGILKYTHNDA 95
K L+G+L H A
Sbjct: 265 GKCLETLKGVLDVAHTCA 282
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 54.7 bits (130), Expect = 5e-07
Identities = 30/91 (32%), Positives = 49/91 (53%), Gaps = 3/91 (3%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
I+D+A+ D ++L+ A+ + L ++D G L+ LKGH + V+C + SGS
Sbjct: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSF 145
Query: 74 DKSVIIWTSKLEGILK--YTHNDAIQCVSYN 102
D++V IW K LK H+D + V +N
Sbjct: 146 DETVKIWEVKTGKCLKTLSAHSDPVSAVHFN 176
Score = 52.8 bits (125), Expect = 2e-06
Identities = 37/152 (24%), Positives = 73/152 (48%), Gaps = 10/152 (6%)
Query: 15 INDIAFKPDGTQLILAAGSRLLV-YDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
++ + F P+G L ++ RL++ + DG + L GH + VA++ D R S S
Sbjct: 44 VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASD 103
Query: 74 DKSVIIWTSKLEGILKYT--HNDAIQCVSYNPITHQLASCSSSD-FGLWSPEQ----KSV 126
DK++ +W + LK H++ + C ++NP ++ + S S + +W + K++
Sbjct: 104 DKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL 163
Query: 127 SKHKSSSKIICCSWTNDGQYLALGMFNGIISI 158
S H S + + G + G ++G+ I
Sbjct: 164 SAH--SDPVSAVHFNCSGSLIVSGSYDGLCRI 193
Score = 46.2 bits (108), Expect = 2e-04
Identities = 35/118 (29%), Positives = 56/118 (47%), Gaps = 11/118 (9%)
Query: 49 LKGHKDTVYCVAYAKDGKRFASGSADKSVIIW---TSKLEGILKYTHNDAIQCVSYNPIT 105
L GH + V V ++ +G+ AS SAD+ +IIW K E L Y HN I V+++ +
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL-YGHNLEISDVAWSSDS 95
Query: 106 HQLASCS-SSDFGLWSPEQ----KSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISI 158
+L S S LW K++ H S+ + CC++ + G F+ + I
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGH--SNYVFCCNFNPPSNLIISGSFDETVKI 151
Score = 45.4 bits (106), Expect = 3e-04
Identities = 29/104 (27%), Positives = 51/104 (49%), Gaps = 6/104 (5%)
Query: 15 INDIAFKPDGTQLILAA-GSRLLVYDTSDGTLLQPLKGHKDTVYCV---AYAKDGKRFAS 70
++ + F P+G ++ A + L ++D S G L+ GHK+ YC+ GK S
Sbjct: 213 VSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVS 272
Query: 71 GSADKSVIIWTSKLEGILK--YTHNDAIQCVSYNPITHQLASCS 112
GS D V IW + + I++ H D + + +P + +AS +
Sbjct: 273 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAA 316
Score = 35.0 bits (79), Expect = 0.44
Identities = 32/141 (22%), Positives = 59/141 (41%), Gaps = 9/141 (6%)
Query: 37 VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKY---THN 93
+++ G L+ L H D V V + G SGS D IW + LK N
Sbjct: 151 IWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDN 210
Query: 94 DAIQCVSYNPI-THQLASCSSSDFGLWSPEQ----KSVSKHKSSSKIICCSWT-NDGQYL 147
+ V ++P + L + + LW + K+ + HK+ I +++ G+++
Sbjct: 211 PPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWI 270
Query: 148 ALGMFNGIISIRNKNGEEKVK 168
G + ++ I N +E V+
Sbjct: 271 VSGSEDNLVYIWNLQTKEIVQ 291
>gi|46358428 selective LIM binding factor homolog [Homo sapiens]
Length = 1749
Score = 53.9 bits (128), Expect = 9e-07
Identities = 56/235 (23%), Positives = 93/235 (39%), Gaps = 22/235 (9%)
Query: 656 GLDFETAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKR 715
GL + A+ R + L EL+ I +GE + A L+++
Sbjct: 777 GLPAKAARLVLTREELLANTELVEHITAALIKGEL---------------YERAGDLFEK 821
Query: 716 SGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAG 775
+ ALE Y F A + P E L D K+ AA+ YI A
Sbjct: 822 IHNPQKALECYRKGNAFMKAVELARLAFPVEVVKLEEAWGDHLVQQKQLDAAINHYIEAR 881
Query: 776 EHVKAIEIC-GDHGW--VDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMG 832
+KAIE G W ++D+ + ++ PL+ A + L A E Y K
Sbjct: 882 CSIKAIEAALGARQWKKAIYILDLQDRNTASKYYPLV--AQHYASLQEYEIAEELYTKGD 939
Query: 833 DLKSLVQLHVETQRWDEAFALGEK--HPEFKDDIYMPYAQWLAENDRFEEAQKAF 885
K + ++ + RW++A L K PE +Y+ AQ + + ++ EA++ +
Sbjct: 940 RTKDAIDMYTQAGRWEQAHKLAMKCMRPEDVSVLYITQAQEMEKQGKYREAERLY 994
Score = 52.8 bits (125), Expect = 2e-06
Identities = 52/208 (25%), Positives = 91/208 (43%), Gaps = 31/208 (14%)
Query: 703 QGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDP---KETKMLITKQADWAR 759
QGK+ EA +LY +LA+ MY +++ +G P +T + + K+ +
Sbjct: 984 QGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLVGKHHPDLLSDTHLHLGKELEAEG 1043
Query: 760 NIKEP----------KAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLL 809
++E KA V MY ++G +A + G + +A
Sbjct: 1044 RLQEAEYHYLEAQEWKATVNMYRASGLWEEAYRVARTQGGANAHKHVA------------ 1091
Query: 810 LCATYLKKLDSPGYAAETYL-KMGDLKSLVQLHVETQRWDEAFALGEKHPEFKD-DIYMP 867
YL G AA L K+G L++ V + ++ AF L + K ++++
Sbjct: 1092 ----YLWAKSLGGEAAVRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKHKTPEVHLK 1147
Query: 868 YAQWLAENDRFEEAQKAFHKAGRQREAV 895
YA +L + +FEEA+ F +AG+ +EAV
Sbjct: 1148 YAMFLEDEGKFEEAEAEFIRAGKPKEAV 1175
Score = 34.7 bits (78), Expect = 0.58
Identities = 54/252 (21%), Positives = 102/252 (40%), Gaps = 33/252 (13%)
Query: 659 FETAKKAFIRVQDLRYLELI----SSIEERKKRGETNNDLFLADVFSYQGK-------FH 707
FE A+ FIR + L+ E ++ E ++ +A+V Q + F
Sbjct: 1158 FEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVGQARGALEEKDFQ 1217
Query: 708 EAAKLYKRSGHENLALEMYTDLCMFEYA----KDFLGS---GDPKETKMLITKQADWARN 760
+A L R+ LAL Y + ++ A KD++ S +E + TK+ AR
Sbjct: 1218 KAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEALQEEYEREATKKG--ARG 1275
Query: 761 IKEPKAAVEMYISAGEHVKAIEI------CGDHGWVDMLIDIARKLD------KAEREPL 808
++ + AGE+ +A++ G+ G + A +L + E +
Sbjct: 1276 VEGFVEQARHWEQAGEYSRAVDCYLKVRDSGNSGLAEKCWMKAAELSIKFLPPQRNMEVV 1335
Query: 809 LLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALG-EKHPEFKDDIYMP 867
L L + AAE YL + +K + +E + W++A + E P ++D +
Sbjct: 1336 LAVGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRVAKELDPRYEDYVDQH 1395
Query: 868 YAQWLAENDRFE 879
Y ++L + +
Sbjct: 1396 YKEFLKNQGKVD 1407
Score = 31.6 bits (70), Expect = 4.9
Identities = 18/72 (25%), Positives = 33/72 (45%), Gaps = 3/72 (4%)
Query: 828 YLKMGDLKSLVQLHVETQRWDEAFALGEK--HPEFKDDIYMPYAQWLAENDRFEEAQKAF 885
+L+ ++ + ++ E RWDE A+ E HP + + Y QWL + + E A +
Sbjct: 702 FLEQNAVEEAMGMYQELHRWDECIAVAEAKGHPAL-EKLRRSYYQWLMDTQQEERAGELQ 760
Query: 886 HKAGRQREAVQV 897
G A+ +
Sbjct: 761 ESQGDGLAAISL 772
Score = 31.6 bits (70), Expect = 4.9
Identities = 29/107 (27%), Positives = 44/107 (41%), Gaps = 17/107 (15%)
Query: 694 LFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITK 753
+FL D +GKF EA + R+G A+ M+ +E A+ + DP ++
Sbjct: 1150 MFLED----EGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVG 1205
Query: 754 QADWARNIKE-------------PKAAVEMYISAGEHVKAIEICGDH 787
QA A K+ P A+ Y AG A+ IC D+
Sbjct: 1206 QARGALEEKDFQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDY 1252
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 53.1 bits (126), Expect = 2e-06
Identities = 26/67 (38%), Positives = 41/67 (61%), Gaps = 1/67 (1%)
Query: 15 INDIAFKPDGTQLILAA-GSRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
I+ + F P+G L A R+L++D G ++ LKGH DTV + +++DG+ ASGS
Sbjct: 672 IHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSM 731
Query: 74 DKSVIIW 80
D +V +W
Sbjct: 732 DNTVRLW 738
Score = 37.7 bits (86), Expect = 0.069
Identities = 24/102 (23%), Positives = 50/102 (49%), Gaps = 5/102 (4%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
+N F P+ + + R + ++D +G ++ GHK ++ + ++ +G+ A+G+
Sbjct: 630 VNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGAT 689
Query: 74 DKSVIIWT---SKLEGILKYTHNDAIQCVSYNPITHQLASCS 112
D V++W + G LK H D + + ++ LAS S
Sbjct: 690 DGRVLLWDIGHGLMVGELK-GHTDTVCSLRFSRDGEILASGS 730
Score = 31.6 bits (70), Expect = 4.9
Identities = 32/159 (20%), Positives = 66/159 (41%), Gaps = 7/159 (4%)
Query: 37 VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWT-SKLEGILKYT-HND 94
+ D + L+ L GH VY +++ D S S D +V +W+ ++ Y HN
Sbjct: 527 IMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNY 586
Query: 95 AIQCVSYNPITHQLASCSSSDFG-LWSPEQKSVSKHKSS--SKIICCSWTNDGQYLALGM 151
+ ++P + S LW+ + + + + + C + + Y+A G
Sbjct: 587 PVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGS 646
Query: 152 FNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSSRW 190
+ + + + V+I G PI S+ ++P+ R+
Sbjct: 647 ADRTVRLWDVLNGNCVRIFT--GHKGPIHSLTFSPNGRF 683
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 50.4 bits (119), Expect = 1e-05
Identities = 43/188 (22%), Positives = 84/188 (44%), Gaps = 18/188 (9%)
Query: 18 IAFKPDGTQLILAAGSRLL-VYDTS-DGTLLQPL--KGHKDTVYCVAYAKDGKRFASGSA 73
+A+ P GT L G R + ++ T D + + + +GH+ TV VA++ G AS S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
Query: 74 DKSVIIWTSKLEGILKYT----HNDAIQCVSYNPITHQLASCS-SSDFGLWSPEQKS--- 125
D + IW + T H + ++ V++ P + LA+CS +W +++
Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
Query: 126 ----VSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWS 181
++ H K + W + LA ++ + + + ++ V G S +WS
Sbjct: 142 CVSVLNSHTQDVKHVV--WHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWS 199
Query: 182 ICWNPSSR 189
+ ++PS +
Sbjct: 200 LAFDPSGQ 207
Score = 40.0 bits (92), Expect = 0.014
Identities = 39/162 (24%), Positives = 68/162 (41%), Gaps = 20/162 (12%)
Query: 99 VSYNPITHQLASCSSSD-FGLWSPEQ-----KSVSKHKSSSKIICCSWTNDGQYLALGMF 152
+++NP LASC +W E KSV + +W+ G YLA F
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
Query: 153 NGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPS-------SRWESFWMNRENEDAE-- 203
+ I KN ++ + G + + S+ W PS SR +S W+ +E+ E
Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
Query: 204 -DVIVNRYIQEIPSTL----KSAVYSSQGSEAEEEEPEEEDD 240
++N + Q++ + + + S+ + + EEEDD
Sbjct: 142 CVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDD 183
Score = 38.5 bits (88), Expect = 0.040
Identities = 23/67 (34%), Positives = 36/67 (53%), Gaps = 5/67 (7%)
Query: 25 TQLILAAGS-----RLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVII 79
+Q +LA+ S +L + D L+GH+ TV+ +A+ G+R AS S D++V I
Sbjct: 161 SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRI 220
Query: 80 WTSKLEG 86
W L G
Sbjct: 221 WRQYLPG 227
>gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1
[Homo sapiens]
Length = 1129
Score = 50.4 bits (119), Expect = 1e-05
Identities = 50/191 (26%), Positives = 80/191 (41%), Gaps = 23/191 (12%)
Query: 16 NDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSAD 74
N + F DGT++ + L+ + D D + + +GH V +++ AS S D
Sbjct: 98 NHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCD 157
Query: 75 KSVIIW-----TSKLEGILKYTHNDAIQCVSYNPITHQ------LASCSSSDFGLWSPE- 122
SV +W T + L ND I S + Q LA L+ E
Sbjct: 158 GSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRES 217
Query: 123 ---QKSVSKHKSSSKIICCSWTNDGQYLALGMFNGII---SIRNKNGEEKVKIERPGGSL 176
Q +S + S + +W+ GQYLA G NG+I ++ K+ E+VK E+
Sbjct: 218 WSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKG---- 273
Query: 177 SPIWSICWNPS 187
I + W+P+
Sbjct: 274 YAICGLAWHPT 284
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,144,784
Number of Sequences: 37866
Number of extensions: 2169323
Number of successful extensions: 10497
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 140
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 9193
Number of HSP's gapped (non-prelim): 1167
length of query: 1241
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1127
effective length of database: 13,930,794
effective search space: 15700004838
effective search space used: 15700004838
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.