Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 164698517
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens]
(956 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens] 1954 0.0
gi|38158013 MAM domain containing 1 isoform 2 [Homo sapiens] 1487 0.0
gi|24111244 MAM domain containing glycosylphosphatidylinositol a... 1039 0.0
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 149 1e-35
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 140 7e-33
gi|7657359 contactin 5 isoform long [Homo sapiens] 135 2e-31
gi|28373129 contactin 5 isoform short [Homo sapiens] 135 2e-31
gi|118572606 hemicentin 1 [Homo sapiens] 130 4e-30
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 125 2e-28
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 125 2e-28
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 125 2e-28
gi|110349719 titin isoform N2-A [Homo sapiens] 123 9e-28
gi|75709184 contactin 3 [Homo sapiens] 123 9e-28
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 121 4e-27
gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Ho... 116 9e-26
gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Ho... 116 9e-26
gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Ho... 116 9e-26
gi|4827022 contactin 2 precursor [Homo sapiens] 114 3e-25
gi|139948432 adlican [Homo sapiens] 114 4e-25
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 113 1e-24
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 112 2e-24
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 110 5e-24
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 110 5e-24
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 109 1e-23
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens] 107 7e-23
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens] 107 7e-23
gi|223278413 MAM domain containing 2 [Homo sapiens] 105 2e-22
gi|7657361 contactin 6 [Homo sapiens] 105 3e-22
gi|237858682 neurofascin isoform 6 precursor [Homo sapiens] 100 6e-21
gi|237858680 neurofascin isoform 5 precursor [Homo sapiens] 100 6e-21
>gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens]
Length = 956
Score = 1954 bits (5062), Expect = 0.0
Identities = 956/956 (100%), Positives = 956/956 (100%)
Query: 1 MDLLYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLEL 60
MDLLYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLEL
Sbjct: 1 MDLLYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLEL 60
Query: 61 TCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPA 120
TCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPA
Sbjct: 61 TCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPA 120
Query: 121 IKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQ 180
IKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQ
Sbjct: 121 IKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQ 180
Query: 181 GSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTA 240
GSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTA
Sbjct: 181 GSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTA 240
Query: 241 SPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAI 300
SPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAI
Sbjct: 241 SPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAI 300
Query: 301 TSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQ 360
TSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQ
Sbjct: 301 TSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQ 360
Query: 361 VEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVAS 420
VEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVAS
Sbjct: 361 VEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVAS 420
Query: 421 LKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRA 480
LKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRA
Sbjct: 421 LKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRA 480
Query: 481 DKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPP 540
DKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPP
Sbjct: 481 DKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPP 540
Query: 541 AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKS 600
AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKS
Sbjct: 541 AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKS 600
Query: 601 LSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQM 660
LSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQM
Sbjct: 601 LSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQM 660
Query: 661 NPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPL 720
NPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPL
Sbjct: 661 NPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPL 720
Query: 721 TKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKY 780
TKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKY
Sbjct: 721 TKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKY 780
Query: 781 TPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFF 840
TPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFF
Sbjct: 781 TPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFF 840
Query: 841 YHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRG 900
YHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRG
Sbjct: 841 YHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRG 900
Query: 901 PGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLISILSPRR 956
PGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLISILSPRR
Sbjct: 901 PGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLISILSPRR 956
>gi|38158013 MAM domain containing 1 isoform 2 [Homo sapiens]
Length = 727
Score = 1487 bits (3850), Expect = 0.0
Identities = 727/727 (100%), Positives = 727/727 (100%)
Query: 230 MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV 289
MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV
Sbjct: 1 MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV 60
Query: 290 LNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNI 349
LNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNI
Sbjct: 61 LNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNI 120
Query: 350 QIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKF 409
QIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKF
Sbjct: 121 QIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKF 180
Query: 410 TDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTG 469
TDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTG
Sbjct: 181 TDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTG 240
Query: 470 KPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPRE 529
KPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPRE
Sbjct: 241 KPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPRE 300
Query: 530 ALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFD 589
ALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFD
Sbjct: 301 ALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFD 360
Query: 590 SQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHR 649
SQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHR
Sbjct: 361 SQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHR 420
Query: 650 VYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIK 709
VYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIK
Sbjct: 421 VYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIK 480
Query: 710 PEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWT 769
PEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWT
Sbjct: 481 PEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWT 540
Query: 770 KQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYG 829
KQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYG
Sbjct: 541 KQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYG 600
Query: 830 PTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPIT 889
PTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPIT
Sbjct: 601 PTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPIT 660
Query: 890 SFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLI 949
SFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLI
Sbjct: 661 SFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLI 720
Query: 950 SILSPRR 956
SILSPRR
Sbjct: 721 SILSPRR 727
Score = 95.9 bits (237), Expect = 2e-19
Identities = 95/380 (25%), Positives = 161/380 (42%), Gaps = 36/380 (9%)
Query: 52 IREGETLELTCLVTG-HPRPQIRWTKTAGSASDRFQDSSVFNE-TLRITNIQRHQGGRYY 109
+ GE + L C+ TG P P + W ++ G+ ++ +V N TL I I G Y
Sbjct: 25 VNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK----TVLNGGTLTIPAITSDDAGTYS 80
Query: 110 CKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNP--PV 167
C A N +G+PA KS + V L + + R V + C + P +
Sbjct: 81 CIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEEL 140
Query: 168 RYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIP 227
+SW + L + +P + G T L + +L+ D+ Y+C+AS++ I
Sbjct: 141 TFSWFKNGRPLRSSERMVITQTDPDVSPGTTN-LDIIDLKFTDFGTYTCVASLKG-GGIS 198
Query: 228 DKMVSFRLSNKTASPSIKLLVD-DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFG--TL 284
D + +S+ T P++ + + P+V G+ I L C T G+P P + W R+ +
Sbjct: 199 DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVT-GKPKPIILWSRADKEVAM 257
Query: 285 PEKTV---LNGGTLTIPAITSDDAGTYSCIANNNVG---NPAKKSTNIIVRALKKGRFWI 338
P+ ++ GTL I ++ + +G Y C + G P + +IV ++
Sbjct: 258 PDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIV------QYPP 311
Query: 339 TPDPYHKDDNIQIGREVKISCQV-EAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSP 397
+P + R V +SC+V A P LT+ W + LR+ Q D S
Sbjct: 312 AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTG------QFD---SQ 362
Query: 398 GTTNLDIIDLKFTDFGTYTC 417
T + L ++G Y C
Sbjct: 363 EYTEYAVKSLSNENYGVYNC 382
>gi|24111244 MAM domain containing glycosylphosphatidylinositol
anchor 1 [Homo sapiens]
Length = 955
Score = 1039 bits (2687), Expect = 0.0
Identities = 495/921 (53%), Positives = 667/921 (72%), Gaps = 17/921 (1%)
Query: 10 LLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPR 69
LL ++ GQGVYAP +IVH+G AC ++E+ SERVYTIREG+TL L CLVTGHPR
Sbjct: 8 LLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPR 67
Query: 70 PQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVY 129
PQ+RWTKTAGSASD+FQ++SVFNETLRI I R QGGRYYCKAENG+G PAIKSIRVDV
Sbjct: 68 PQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQ 127
Query: 130 YLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIY 189
YLD+P++TVHQ++ + + FY E+TVFLRC NSNPP R+ W+RG + L D GV+IY
Sbjct: 128 YLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIY 187
Query: 190 EPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVD 249
EP +TQGETK+LKLKNLRPQDYA+Y+C SVRNVC IPDK ++FRL+N TA P++KL V+
Sbjct: 188 EPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVN 247
Query: 250 DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYS 309
+ +VVNPGE +T+ C+ TGG+P P L W G LP + GGTL+IP++ + D+G Y+
Sbjct: 248 ETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYN 307
Query: 310 CIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEEL 369
C A NNVGNPAKK+ N++VR++K F ITPD + +NIQ+G+++K+SC V+AVP E++
Sbjct: 308 CTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKV 367
Query: 370 TFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDI 429
T+ WFKNG+P R S+R+++T+ DP++ T++L++IDL F+D+GTY C+AS G + D+
Sbjct: 368 TYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDL 427
Query: 430 SIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVA-MPD 488
S++VNISS TVPP ++VP+ ++ + REG ELQC+V GKP+P +LWSR DKE A +P
Sbjct: 428 SVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPS 487
Query: 489 GSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLE 548
G E+ DG LR+ VSR+MSG YRCQT++YNGFNV+PREA VQL VQ+PP VEP+ +
Sbjct: 488 GLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQD 547
Query: 549 IRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLR-----TGQFDSQEYTEYAVKSLSN 603
+RQ R V + C +LR P R+ + WR +LL ++ ++ E + +++
Sbjct: 548 VRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTR 607
Query: 604 ENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNR-HRVYSYSLQWTQMNP 662
++ G Y CS+ N+ G+ C F V+ KAY+PEFY+DT NP ++ + YSY LQWTQ P
Sbjct: 608 DSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREP 667
Query: 663 DAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTK 722
DAVD ++ YRL IRQ Q + I + ++KG+L+ Y LT+L P +YEVRLTP T
Sbjct: 668 DAVDPVLNYRLSIRQLNQHNAVVKAIPVR-RVEKGQLLEYILTDLRVPHSYEVRLTPYTT 726
Query: 723 FGEGDSTIRVIKYSAPVN-PHLREFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYT 781
FG GD R+I Y+ P+N P+L + C FED IC +TQD TDNFDWT+Q+ T+N K +
Sbjct: 727 FGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRS 786
Query: 782 PNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFY 841
PNTGP D SG+ EG+YM+IETSRPR G++ARL+SP+++ + K YC SFFY
Sbjct: 787 PNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAK--------FYCVSFFY 838
Query: 842 HMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGP 901
HMYG+HIG LN+ +R + + ++ WS SGNKG W +AHV I P FQ+IFEG+RGP
Sbjct: 839 HMYGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGP 898
Query: 902 GIEGDIAIDDVSIAEGECAKQ 922
G GDIAIDDV++ +GEC ++
Sbjct: 899 GYLGDIAIDDVTLKKGECPRK 919
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 149 bits (376), Expect = 1e-35
Identities = 166/707 (23%), Positives = 289/707 (40%), Gaps = 97/707 (13%)
Query: 54 EGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDS--SVFNETLRITNIQRHQ-GGRYYC 110
E + ++L C V G+P+P IRW K G+ D D SV +L I N + Q G Y C
Sbjct: 42 EEKKVKLNCEVKGNPKPHIRW-KLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQC 100
Query: 111 KAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPP---- 166
A N G+ + ++ YLD+ ++ + Q + L C PP
Sbjct: 101 TATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQ-----GMVLLC----GPPPHSG 151
Query: 167 -VRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIAS--VRN- 222
+ Y+W + Q + + F ET L + + D NY+C+ + V N
Sbjct: 152 ELSYAWIFNEYPSYQDNRR--------FVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNH 203
Query: 223 -VCNIPDKMVSFRLSNKTA----SPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTW 277
V P ++ L N P I++ + + G + L C G P P++ W
Sbjct: 204 KVLGPPTPLI---LRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGN-PVPTIIW 259
Query: 278 VRSFG---TLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKG 334
R+ G + + G L IP +DAG Y C+A N+ G + +
Sbjct: 260 RRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARG---------QL 310
Query: 335 RFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPD 394
F+ P+ K ++I + E + + +A + T+ W KNG PL + +R+ I Q
Sbjct: 311 TFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQ---- 366
Query: 395 VSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLV 454
GT N+ I++L +D G Y C+A K G I + +S V P+ + K +
Sbjct: 367 ---GTLNITIVNL--SDAGMYQCLAENKHGVIFS---NAELSVIAVGPDFSRTLLKRVTL 418
Query: 455 TREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYR 514
+ G + ++C+ PKP+ W + +++ + + + S DG LRI+NV++ +G Y
Sbjct: 419 VKVGGEVVIECKPKASPKPVYTWKKG-RDILKENERITI-SEDGNLRIINVTKSDAGSYT 476
Query: 515 CQTSQYNGFNVKPREALVQLIVQYPP--AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVL 572
C + + G + L+V+ P V P+ +++ G+ S+ + C+V + + ++
Sbjct: 477 CIATNHFG----TASSTGNLVVKDPTRVMVPPSSMDVTVGE--SIVLPCQVTHDHSLDIV 530
Query: 573 TYEW----------RLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAG--AG 620
+ W R G+ R G DS + ++++ ++ G Y C + +
Sbjct: 531 -FTWSFNGHLIDFDRDGDHFERVGGQDSA--GDLMIRNIQLKHAGKYVCMVQTSVDRLSA 587
Query: 621 RCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQ 680
+V G PE T + + + L W + PD I Y + R
Sbjct: 588 AADLIVRGPPGPPEAV--TIDEITDT-----TAQLSW-RPGPDNHSPITMYVIQARTPFS 639
Query: 681 QRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGD 727
W Q + + G+ T + L YE R G G+
Sbjct: 640 VGW--QAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGE 684
Score = 102 bits (253), Expect = 2e-21
Identities = 100/372 (26%), Positives = 151/372 (40%), Gaps = 36/372 (9%)
Query: 13 VLLEGISGQGVYAPPTVRIVHS-GLACNIE---EERYSERVYTIREGETLELTCLVTGHP 68
V+ ++ V PPT I+ + G+ E E ++ E V T + G T++L C G+P
Sbjct: 195 VVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAK-GATVKLECFALGNP 253
Query: 69 RPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDV 128
P I W + G R N L I N Q+ G Y C AEN G +
Sbjct: 254 VPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQL--T 311
Query: 129 YYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEI 188
+Y + I A E+ VF C AN P Y W + E LL +E
Sbjct: 312 FYAQPNWIQKINDIHVAMEE-----NVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIE- 365
Query: 189 YEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLV 248
QG T + + NL D Y C+A ++ + +S S + L+
Sbjct: 366 ------QG-TLNITIVNL--SDAGMYQCLAENKHGVIFSNAELSVIAVGPDFS---RTLL 413
Query: 249 DDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK---TVLNGGTLTIPAITSDDA 305
+V G + + C P P TW + L E T+ G L I +T DA
Sbjct: 414 KRVTLVKVGGEVVIEC-KPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDA 472
Query: 306 GTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVP 365
G+Y+CIA N+ G A + N++V+ R + P ++ +G + + CQV
Sbjct: 473 GSYTCIATNHFGT-ASSTGNLVVK--DPTRVMVPPSSM----DVTVGESIVLPCQVTHDH 525
Query: 366 SEELTFSWFKNG 377
S ++ F+W NG
Sbjct: 526 SLDIVFTWSFNG 537
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 140 bits (352), Expect = 7e-33
Identities = 139/526 (26%), Positives = 218/526 (41%), Gaps = 71/526 (13%)
Query: 35 GLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNET 94
GLA I E S V EG+TL+L C+V G Q+ W K GS R Q
Sbjct: 2922 GLAQPIYIEASSSHV---TEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQ---THGSQ 2975
Query: 95 LRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDV-------YYLDDPVVTVHQSIGEAKE 147
LR+ + G Y C+A +G G S V V Y L PV+++ ++
Sbjct: 2976 LRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQ 3035
Query: 148 QFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLR 207
+ F + + P+ W+ + E+ + I+ + R
Sbjct: 3036 G---QDASFKCLIHDGAAPISLEWK----------TRNQELEDNVHISPNGSIITIVGTR 3082
Query: 208 PQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTT 267
P ++ Y C+AS N + +V+ + P++ +L + P+ V G+A+TL CV +
Sbjct: 3083 PSNHGTYRCVAS--NAYGVAQSVVNLSVH---GPPTVSVLPEGPVWVKVGKAVTLECV-S 3136
Query: 268 GGEPAPSLTWVRSFGT---LPEKT---VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAK 321
GEP S W R T L ++T + + L I + DAGTY C+A N +G A+
Sbjct: 3137 AGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGT-AQ 3195
Query: 322 KSTNIIV--RALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRP 379
K +IV A+ G + + + ++ G + C P+ T W K P
Sbjct: 3196 KQVEVIVDTGAMAPGAPQVQAE--EAELTVEAGHTATLRCSATGSPAP--TIHWSKLRSP 3251
Query: 380 LRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSST 439
L R+ + D + P D G Y C A+ G ++ +I +++ S
Sbjct: 3252 LPWQHRL---EGDTLIIPRVAQ--------QDSGQYICNAT-SPAGHAEATIILHVESP- 3298
Query: 440 VPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT 499
P TVP+ S + G+T++LQC G P WSR ++P + + +
Sbjct: 3299 -PYATTVPEHAS---VQAGETVQLQCLAHGTPPLTFQWSRVGS--SLPG---RATARNEL 3349
Query: 500 LRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPA 545
L + E SG YRC+ + V EA QL+VQ PP PA
Sbjct: 3350 LHFERAAPEDSGRYRCRVTN----KVGSAEAFAQLLVQGPPGSLPA 3391
Score = 116 bits (291), Expect = 9e-26
Identities = 141/602 (23%), Positives = 233/602 (38%), Gaps = 75/602 (12%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCK 111
+ +G + L C V+G P W++ G L ++Q G Y C
Sbjct: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICT 1747
Query: 112 AENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYE-RTVFLRCVANS-NPPVRY 169
N S + R ++ + P + ++ E + Q V C A S +P
Sbjct: 1748 CRNLHQS---NTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTL 1804
Query: 170 SWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDK 229
W R L P IL ++N++ D Y C S +
Sbjct: 1805 VWTRLHNGKL-----------PTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTA 1853
Query: 230 MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRS-FGTLPEKT 288
+ + S ++P + + + V PG+ C T G P P+L W G LP K
Sbjct: 1854 TLHVQASGTLSAPVVS-IHPPQLTVQPGQLAEFRCSAT-GSPTPTLEWTGGPGGQLPAKA 1911
Query: 289 VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDN 348
++GG L +PA+ D Y C A+++ G ++ + V R ++P+
Sbjct: 1912 QIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAV-LHVHGGGGPRVQVSPE----RTQ 1966
Query: 349 IQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLK 408
+ GR V++ C+ VPS T +W K G L R T + P T
Sbjct: 1967 VHAGRTVRLYCRAAGVPS--ATITWRKEGGSLPPQARSERTDIATLLIPAITT------- 2017
Query: 409 FTDFGTYTCVA-SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQV 467
D G Y CVA S G + I + V +S PP + + + SP VT EG T++L C V
Sbjct: 2018 -ADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKI-ESSSPSVT-EGQTLDLNCVV 2074
Query: 468 TGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKP 527
G + W R + ++P + + LR+ VS SG Y C+ +G P
Sbjct: 2075 AGSAHAQVTWYR--RGGSLPP---HTQVHGSRLRLPQVSPADSGEYVCRVENGSG----P 2125
Query: 528 REALVQLIVQY----------------PPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRV 571
+EA + + V + P +EP+ + +GQ ++ ++C V +V
Sbjct: 2126 KEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQ--TLDLNCVVPGQAHAQV 2183
Query: 572 LTYEWRLGNKLLRTGQFDSQEYTEYAVKSL---SNENYGVYNCSIINEAGAGRCSFLVTG 628
++ R G ++ T ++ L + + G Y C ++ +G S LVT
Sbjct: 2184 TWHK--------RGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTI 2235
Query: 629 KA 630
+A
Sbjct: 2236 EA 2237
Score = 111 bits (278), Expect = 3e-24
Identities = 154/672 (22%), Positives = 251/672 (37%), Gaps = 85/672 (12%)
Query: 16 EGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWT 75
+ + V+ PPTV ++ G ++ G+ + L C+ G PR RWT
Sbjct: 3101 QSVVNLSVHGPPTVSVLPEGPVW-------------VKVGKAVTLECVSAGEPRSSARWT 3147
Query: 76 K---TAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLD 132
+ T R + L+I++ + G Y C A+N LG+ A K + V V
Sbjct: 3148 RISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGT-AQKQVEVIVDTGA 3206
Query: 133 DPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPF 192
EA+ T LRC A +P W + + L P+
Sbjct: 3207 MAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPL------------PW 3254
Query: 193 FTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPI 252
+ E L + + QD Y C A+ P + SP V +
Sbjct: 3255 QHRLEGDTLIIPRVAQQDSGQYICNATS------PAGHAEATIILHVESPPYATTVPEHA 3308
Query: 253 VVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIA 312
V GE + L C+ G P + W R +LP + L +D+G Y C
Sbjct: 3309 SVQAGETVQLQCLAHGTPPL-TFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRV 3367
Query: 313 NNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVK---ISCQVE---AVPS 366
N VG+ A+ ++V+ G T P +Q+ +++ I VE AVPS
Sbjct: 3368 TNKVGS-AEAFAQLLVQG-PPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPS 3425
Query: 367 EELT-FSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGG 425
+ T WFK G L V G + +D GTY C A G
Sbjct: 3426 DRGTQLRWFKEGGQLPPGH---------SVQDGVLRIQNLDQSCQ--GTYICQAHGPWGK 3474
Query: 426 ISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVA 485
+ S + I + P++ + S G +E +C G PKP + WS+ +
Sbjct: 3475 -AQASAQLVIQAL---PSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLR 3530
Query: 486 MPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPA 545
G +Q G +RI +V +G YRC + G ++ V L+VQ P +
Sbjct: 3531 --PGIVQS---GGVVRIAHVELADAGQYRCTATNAAG----TTQSHVLLLVQALPQISMP 3581
Query: 546 FLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQ-EYTEYAVKSLSNE 604
E+R + C + YP +++ +KL + DS+ E + S+ +
Sbjct: 3582 -QEVRVPAGSAAVFPC-IASGYPTPDISW-----SKLDGSLPPDSRLENNMLMLPSVRPQ 3634
Query: 605 NYGVYNCSIINEAGAGRC-SFLVTGKAYAPEFYYDTYN----PVWQNRHRVYSYSLQWTQ 659
+ G Y C+ N G + + L + P F Y+ P ++ +R + + +
Sbjct: 3635 DAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITF-- 3692
Query: 660 MNPDAVDRIVAY 671
PD+ D ++ Y
Sbjct: 3693 -RPDSADGMLLY 3703
Score = 107 bits (267), Expect = 5e-23
Identities = 150/666 (22%), Positives = 260/666 (39%), Gaps = 104/666 (15%)
Query: 6 GLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVT 65
G+ +TV + G G + P +G I E S +V EG+TL+L C+V
Sbjct: 2316 GMEASITVTVTGTQGANLAYP-------AGSTQPIRIEPSSSQV---AEGQTLDLNCVVP 2365
Query: 66 GHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIR 125
G Q+ W K GS R Q LR+ G Y C+ G P S+
Sbjct: 2366 GQSHAQVTWHKRGGSLPVRHQ---THGSLLRLYQASPADSGEYVCRVL-GSSVPLEASVL 2421
Query: 126 VDVYYLDD-------PVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSW-RRGQEV 177
V + P V + S + E +T+ L C+ + +W +RG +
Sbjct: 2422 VTIEPAGSVPALGVTPTVRIESSSSQVAEG----QTLDLNCLVAGQAHAQVTWHKRGGSL 2477
Query: 178 LLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSF--RL 235
P Q L+L + P D Y C + +V+ RL
Sbjct: 2478 -------------PARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRL 2524
Query: 236 S---NKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNG 292
S ++ + +++ + N G + L C+ P ++TW + G+LP + + G
Sbjct: 2525 SGSHSQGVAYPVRIESSSASLAN-GHTLDLNCLVASQAPH-TITWYKRGGSLPSRHQIVG 2582
Query: 293 GTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWI--TPDPYHKDDN-- 348
L IP +T D+G Y C +N G+ + T++IV G + P + +
Sbjct: 2583 SRLRIPQVTPADSGEYVCHVSNGAGS---RETSLIVTIQGSGSSHVPSVSPPIRIESSSP 2639
Query: 349 -IQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDL 407
+ G+ + ++C V P +T W+K G L S + ++L + +
Sbjct: 2640 TVVEGQTLDLNCVVARQPQAIIT--WYKRGGSLPSRHQ-----------THGSHLRLHQM 2686
Query: 408 KFTDFGTYTCVASLKGGGISDISIDVNISSSTVPP-----NLTVPQEKSPLVTREGDTIE 462
D G Y C A+ + + SI +++S S P ++ + E S EG+T++
Sbjct: 2687 SVADSGEYVCRANNNIDAL-EASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLD 2745
Query: 463 LQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNG 522
L C V G+ + W + + ++P ++ LR+ +VS SG Y C+ +G
Sbjct: 2746 LNCVVPGQAHAQVTWHK--RGGSLPS---HHQTRGSRLRLHHVSPADSGEYVCRVMGSSG 2800
Query: 523 FNVKPREALVQLIVQY---------------PPAVEPAFLEIRQGQDRSVTMSCRVLRAY 567
P EA V + ++ P +EP+ + +GQ ++ + C V+
Sbjct: 2801 ----PLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQ--TLDLKC-VVPGQ 2853
Query: 568 PIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 627
+T+ R GN R + +S + G Y+C + +G S LVT
Sbjct: 2854 AHAQVTWHKRGGNLPAR----HQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVT 2909
Query: 628 GKAYAP 633
+ +P
Sbjct: 2910 IEPSSP 2915
Score = 105 bits (262), Expect = 2e-22
Identities = 136/601 (22%), Positives = 230/601 (38%), Gaps = 77/601 (12%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYC 110
T++ G+ E C TG P P + WT G + + LR+ ++ +Y C
Sbjct: 1876 TVQPGQLAEFRCSATGSPTPTLEWT--GGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLC 1933
Query: 111 KAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYS 170
+A + G +++ + V+ P V V + Q + RTV L C A P +
Sbjct: 1934 RAHSSAGQQVARAV-LHVHGGGGPRVQVSPE----RTQVHAGRTVRLYCRAAGVPSATIT 1988
Query: 171 WRR-GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDK 229
WR+ G + Q + +I L + + D Y C+A+
Sbjct: 1989 WRKEGGSLPPQARSERTDI----------ATLLIPAITTADAGFYLCVATSPAGTAQARI 2038
Query: 230 MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV 289
V ++ + P +K+ P V G+ + L CV G A +TW R G+LP T
Sbjct: 2039 QVVVLSASDASPPPVKIESSSPSVTE-GQTLDLNCVVAGSAHA-QVTWYRRGGSLPPHTQ 2096
Query: 290 LNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDP------- 342
++G L +P ++ D+G Y C N G T ++ G + TP P
Sbjct: 2097 VHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSY-TPVPGSTRPIR 2155
Query: 343 -YHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTN 401
++ G+ + ++C V ++T W K G L + QT +
Sbjct: 2156 IEPSSSHVAEGQTLDLNCVVPGQAHAQVT--WHKRGGSLPARH-----QTHGSL------ 2202
Query: 402 LDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVP-PNLTVPQEKSPLVTREGDT 460
L + + D G Y C G + + S+ V I +S +P P V E S EG T
Sbjct: 2203 LRLHQVTPADSGEYVCHVVGTSGPL-EASVLVTIEASVIPGPIPPVRIESSSSTVAEGQT 2261
Query: 461 IELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQY 520
++L C V G+ + W + + + + L I S +G Y C+ S
Sbjct: 2262 LDLSCVVAGQAHAQVTWYKRGGSL-----PARHQVRGSRLYIFQASPADAGQYVCRAS-- 2314
Query: 521 NGFNVKPREALVQLIV--------------QYPPAVEPAFLEIRQGQDRSVTMSCRVLRA 566
NG EA + + V P +EP+ ++ +GQ ++ ++C V+
Sbjct: 2315 NGM-----EASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQ--TLDLNC-VVPG 2366
Query: 567 YPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLV 626
+T+ R G+ +R S + S + G Y C ++ + S LV
Sbjct: 2367 QSHAQVTWHKRGGSLPVRHQTHGSL----LRLYQASPADSGEYVCRVLGSSVPLEASVLV 2422
Query: 627 T 627
T
Sbjct: 2423 T 2423
Score = 102 bits (254), Expect = 2e-21
Identities = 137/601 (22%), Positives = 225/601 (37%), Gaps = 79/601 (13%)
Query: 51 TIREGETLELTCLVTGHPRP-QIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYY 109
T+++G+ CL+ P + W KT + S + I + G Y
Sbjct: 3032 TVQQGQDASFKCLIHDGAAPISLEW-KTRNQELEDNVHISPNGSIITIVGTRPSNHGTYR 3090
Query: 110 CKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRY 169
C A N G + V++ P V+V + E + V L CV+ P
Sbjct: 3091 CVASNAYG---VAQSVVNLSVHGPPTVSV---LPEGPVWVKVGKAVTLECVSAGEPRSSA 3144
Query: 170 SWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDK 229
W R + + +E + +L++ + +P D Y C+A +N K
Sbjct: 3145 RWTR-----ISSTPAKLE-QRTYGLMDSHAVLQISSAKPSDAGTYVCLA--QNALGTAQK 3196
Query: 230 MVSFRLSNKTASPSIKLLVDDP--IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK 287
V + +P + + + V G TL C TG PAP++ W + LP +
Sbjct: 3197 QVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGS-PAPTIHWSKLRSPLPWQ 3255
Query: 288 TVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDD 347
L G TL IP + D+G Y C N +PA + I+ ++ + T P H
Sbjct: 3256 HRLEGDTLIIPRVAQQDSGQYIC----NATSPAGHAEATIILHVESPPY-ATTVPEHA-- 3308
Query: 348 NIQIGREVKISCQVEAVPSEELTFSWFK-----NGRPLRSSERMVITQTDPDVSPGTTNL 402
++Q G V++ C P LTF W + GR +E + + P+
Sbjct: 3309 SVQAGETVQLQCLAHGTP--PLTFQWSRVGSSLPGRATARNELLHFERAAPE-------- 3358
Query: 403 DIIDLKFTDFGTYTCVASLKGGGISDISIDV------NISSSTVPPNLTVPQEKSPLVTR 456
D G Y C + K G + + ++ ++++P T + +P +
Sbjct: 3359 --------DSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLET 3410
Query: 457 E--GDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYR 514
+ G ++E C V + W + ++ P S+Q DG LRI N+ + G Y
Sbjct: 3411 KSIGASVEFHCAVPSDRGTQLRWFKEGGQLP-PGHSVQ----DGVLRIQNLDQSCQGTYI 3465
Query: 515 CQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQD-----RSVTMSCRVLRAYPI 569
CQ G +A QL++Q P+V + IR +V C L
Sbjct: 3466 CQAHGPWG----KAQASAQLVIQALPSV---LINIRTSVQTVVVGHAVEFECLALGDPKP 3518
Query: 570 RVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGK 629
+V W LR G S A L++ G Y C+ N AG + L+ +
Sbjct: 3519 QV---TWSKVGGHLRPGIVQSGGVVRIAHVELADA--GQYRCTATNAAGTTQSHVLLLVQ 3573
Query: 630 A 630
A
Sbjct: 3574 A 3574
Score = 93.2 bits (230), Expect = 1e-18
Identities = 130/558 (23%), Positives = 211/558 (37%), Gaps = 84/558 (15%)
Query: 47 ERVYTIREGETLELTCLVTGH-PRPQIRWTKTA-GSASDRFQDSSVFNETLRITNIQRHQ 104
+R ++R G + C P + WT+ G R D FN L I N+Q
Sbjct: 1778 QRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMD---FNGILTIRNVQLSD 1834
Query: 105 GGRYYCKAENGLG-SPAIKSIRVDVY-YLDDPVVTVHQSIGEAKEQFYYERTVFLRCVAN 162
G Y C N ++ V L PVV++H + E RC A
Sbjct: 1835 AGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAE----FRCSAT 1890
Query: 163 SNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRN 222
+P W G L P Q IL+L + P D A Y C A
Sbjct: 1891 GSPTPTLEWTGGPGGQL-----------PAKAQIHGGILRLPAVEPTDQAQYLCRAHSSA 1939
Query: 223 VCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFG 282
+ ++ + P ++ + + V+ G + L C G P+ ++TW + G
Sbjct: 1940 GQQVARAVLHV---HGGGGPRVQ-VSPERTQVHAGRTVRLYC-RAAGVPSATITWRKEGG 1994
Query: 283 TLP-----EKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFW 337
+LP E+T + TL IPAIT+ DAG Y C+A + G + +++ A
Sbjct: 1995 SLPPQARSERTDI--ATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASD----- 2047
Query: 338 ITPDPY---HKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPD 394
+P P ++ G+ + ++C V ++T W++ G L P
Sbjct: 2048 ASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVT--WYRRGGSL-----------PPH 2094
Query: 395 VSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNI-------SSSTVPPNLTVP 447
+ L + + D G Y C G G + SI V++ S T P T P
Sbjct: 2095 TQVHGSRLRLPQVSPADSGEYVCRVE-NGSGPKEASITVSVLHGTHSGPSYTPVPGSTRP 2153
Query: 448 --QEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNV 505
E S EG T++L C V G+ + W + + + +++ LR+ V
Sbjct: 2154 IRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL-----PARHQTHGSLLRLHQV 2208
Query: 506 SREMSGMYRCQTSQYNGFNVKPREALVQLIVQY--------PPAVEPAFLEIRQGQDRSV 557
+ SG Y C +G P EA V + ++ P +E + + +GQ ++
Sbjct: 2209 TPADSGEYVCHVVGTSG----PLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQ--TL 2262
Query: 558 TMSCRVLRAYPIRVLTYE 575
+SC V +V Y+
Sbjct: 2263 DLSCVVAGQAHAQVTWYK 2280
Score = 73.6 bits (179), Expect = 8e-13
Identities = 113/501 (22%), Positives = 192/501 (38%), Gaps = 74/501 (14%)
Query: 157 LRCVANSNPPVRYSWRR--GQEVL--LQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYA 212
LRC + +PP + W R G+ V Q +G E++ P +++P D
Sbjct: 1696 LRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFP-------------SVQPSDAG 1742
Query: 213 NYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIV--VNPGEAITLVCVTTGGE 270
Y C + RN+ ++ + P I + V++ V PG +T +C
Sbjct: 1743 VYIC--TCRNLHQSNTSRAELLVTEAPSKP-ITVTVEEQRSQSVRPGADVTFICTAKSKS 1799
Query: 271 PAPSLTWVRSF-GTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVR 329
PA +L W R G LP + + G LTI + DAGTY C +N +T +
Sbjct: 1800 PAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTAT---LH 1856
Query: 330 ALKKGRFWITPDPYHKDD-NIQIGREVKISCQVEAVPSEELTFSWFKNGR-PLRSSERMV 387
G H +Q G+ + C P+ L ++ G+ P ++
Sbjct: 1857 VQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGG 1916
Query: 388 ITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVA-SLKGGGISDISIDVNISSSTVPPNLTV 446
I + P V P TD Y C A S G ++ + V+ P + V
Sbjct: 1917 ILRL-PAVEP------------TDQAQYLCRAHSSAGQQVARAVLHVHGGGG---PRVQV 1960
Query: 447 PQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVS 506
E++ + G T+ L C+ G P I W + + ++P + + TL I ++
Sbjct: 1961 SPERTQV--HAGRTVRLYCRAAGVPSATITWRK--EGGSLPPQARSERTDIATLLIPAIT 2016
Query: 507 REMSGMYRCQTSQYNGFNVKPREALVQLIV-------QYPPAVEPAFLEIRQGQDRSVTM 559
+G Y C + G +A +Q++V P +E + + +GQ ++ +
Sbjct: 2017 TADAGFYLCVATSPAG----TAQARIQVVVLSASDASPPPVKIESSSPSVTEGQ--TLDL 2070
Query: 560 SCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGA 619
+C V + +V Y R G L Q + + +S + G Y C + N +G
Sbjct: 2071 NCVVAGSAHAQVTWY--RRGGSLPPHTQVHG---SRLRLPQVSPADSGEYVCRVENGSGP 2125
Query: 620 GRCSFLV-------TGKAYAP 633
S V +G +Y P
Sbjct: 2126 KEASITVSVLHGTHSGPSYTP 2146
Score = 44.3 bits (103), Expect = 6e-04
Identities = 45/172 (26%), Positives = 65/172 (37%), Gaps = 10/172 (5%)
Query: 444 LTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIV 503
L V + + +G + L+CQV+G P WSR D +P G+ Q L
Sbjct: 1677 LVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGR-PVPSGTQQRHQ-GSELHFP 1734
Query: 504 NVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV---EPAFLEIRQGQDRSVTMS 560
+V +G+Y C + N E LV P V E +R G D VT
Sbjct: 1735 SVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGAD--VTFI 1792
Query: 561 CRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCS 612
C P L + RL N L T D ++++ + G Y C+
Sbjct: 1793 CTAKSKSPAYTLVWT-RLHNGKLPTRAMDFNGI--LTIRNVQLSDAGTYVCT 1841
Score = 42.4 bits (98), Expect = 0.002
Identities = 29/108 (26%), Positives = 46/108 (42%), Gaps = 2/108 (1%)
Query: 440 VPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV-AMPDGSMQMESYDG 498
+PP + P +S +R G T+ C G P PII W + + P ++ E G
Sbjct: 404 MPPQVVTPPRESIQASR-GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG 462
Query: 499 TLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAF 546
TL I +V G Y C+ G + +++L+ Q P + F
Sbjct: 463 TLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHF 510
Score = 37.4 bits (85), Expect = 0.067
Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 7/74 (9%)
Query: 250 DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK---TVLNGG---TLTIPAITSD 303
+ I + G+ +T CV G P P + W ++G +P TV + G TL I +
Sbjct: 414 ESIQASRGQTVTFTCVAIG-VPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKES 472
Query: 304 DAGTYSCIANNNVG 317
D G Y+C A N G
Sbjct: 473 DQGAYTCEAMNARG 486
Score = 33.1 bits (74), Expect = 1.3
Identities = 38/147 (25%), Positives = 56/147 (38%), Gaps = 19/147 (12%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGSASDRFQ---DSSVFNETLRITNIQRHQGGRYYCK 111
G+T+ TC+ G P P I W G + S TL I +++ G Y C+
Sbjct: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE 480
Query: 112 AENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKE-QFYYERT-VFLRCVANSNPPVRY 169
A N G V+ + D V+ + G + FY E + L C V
Sbjct: 481 AMNARGM---------VFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCFCFGITSVCQ 531
Query: 170 SWRRGQEVLLQGSD-----KGVEIYEP 191
S RR ++ + D KGV + P
Sbjct: 532 STRRFRDQIRLRFDQPDDFKGVNVTMP 558
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 135 bits (340), Expect = 2e-31
Identities = 168/705 (23%), Positives = 275/705 (39%), Gaps = 86/705 (12%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDS--SVFNETLRITN-IQRHQGGR 107
T + + + L C V G+P P RW + G+ D D S+ + T I+N + G
Sbjct: 112 TDSDEKKVALNCEVRGNPVPSYRWLRN-GTEIDLESDYRYSLIDGTFIISNPSEAKDSGH 170
Query: 108 YYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPP- 166
Y C A N +GS + + YL + ++ + Q V L C + P
Sbjct: 171 YQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQ-----GVVLMCSPPPHSPE 225
Query: 167 VRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNI 226
+ YSW + D F +Q ET L + ++ D +Y C+ V N
Sbjct: 226 IIYSWVFNEFPSFVAEDS-----RRFISQ-ETGNLYISKVQTSDVGSYICLVK-NTVTNA 278
Query: 227 ----PDKMVSFRLSNKTASPSIKLLVDDPIVVNP--GEAITLVCVTTGGEPAPSLTWVRS 280
P ++ R K+ V P V G + + C G P P++TW++
Sbjct: 279 RVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGN-PVPTITWMKV 337
Query: 281 FGTLPEKTVL--NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWI 338
G +P K L + L IP + DDAG Y C A N+ G + + G+ +
Sbjct: 338 NGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFR-----------GQLQV 386
Query: 339 TPDPYH----KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPD 394
P+ D + G ++ C+ P T+ W KNG PL R+ +
Sbjct: 387 YTYPHWVEKLNDTQLDSGSPLRWECKATGKPRP--TYRWLKNGVPLSPQSRVEMVNGV-- 442
Query: 395 VSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLV 454
L I ++ +D G Y C+A K G I S ++ I +S P + Q K ++
Sbjct: 443 -------LMIHNVNQSDAGMYQCLAENKYGAIY-ASAELKILASA--PTFALNQLKKTII 492
Query: 455 TREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYR 514
+ + ++C+ G PKP I W + D+ A+ + DG+LRI+N S+ G Y
Sbjct: 493 VTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPDGSLRILNASKSDEGKYV 550
Query: 515 CQTSQYNGFNVKPREALVQLIVQYPPAVE--PAFLEIRQGQDRSVTMSCRVLRAYPIRVL 572
C+ G E + L V+ P +E P E+ G+ S+ ++C+ + + V
Sbjct: 551 CRGENVFG----SAEIIASLSVKEPTRIELTPKRTELTVGE--SIVLNCKAIHDASLDV- 603
Query: 573 TYEWRLGNKLL----RTGQFDS----QEYTEYAVKSLSNENYGVYNCSIINEAG--AGRC 622
T+ W L + + G F+S + ++++ + G Y C + A +
Sbjct: 604 TFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEA 663
Query: 623 SFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQR 682
LV G P V + +L W+ D I +Y L R
Sbjct: 664 ELLVRGPPGPPGI-------VIVEEITESTATLSWSPA-ADNHSPISSYNLQARSPFSLG 715
Query: 683 WWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGD 727
W Q +K I G++ + +L YE R+ G GD
Sbjct: 716 W--QTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGD 758
Score = 41.6 bits (96), Expect = 0.004
Identities = 23/99 (23%), Positives = 47/99 (47%), Gaps = 3/99 (3%)
Query: 23 VYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSAS 82
+YA ++I+ S + + + + + + + + + C G P+P I W K +
Sbjct: 467 IYASAELKILASAPTFALNQLK---KTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVR 523
Query: 83 DRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAI 121
+ + + + + +LRI N + G+Y C+ EN GS I
Sbjct: 524 ENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEI 562
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 135 bits (340), Expect = 2e-31
Identities = 168/705 (23%), Positives = 275/705 (39%), Gaps = 86/705 (12%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDS--SVFNETLRITN-IQRHQGGR 107
T + + + L C V G+P P RW + G+ D D S+ + T I+N + G
Sbjct: 38 TDSDEKKVALNCEVRGNPVPSYRWLRN-GTEIDLESDYRYSLIDGTFIISNPSEAKDSGH 96
Query: 108 YYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPP- 166
Y C A N +GS + + YL + ++ + Q V L C + P
Sbjct: 97 YQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQ-----GVVLMCSPPPHSPE 151
Query: 167 VRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNI 226
+ YSW + D F +Q ET L + ++ D +Y C+ V N
Sbjct: 152 IIYSWVFNEFPSFVAEDS-----RRFISQ-ETGNLYISKVQTSDVGSYICLVK-NTVTNA 204
Query: 227 ----PDKMVSFRLSNKTASPSIKLLVDDPIVVNP--GEAITLVCVTTGGEPAPSLTWVRS 280
P ++ R K+ V P V G + + C G P P++TW++
Sbjct: 205 RVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGN-PVPTITWMKV 263
Query: 281 FGTLPEKTVL--NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWI 338
G +P K L + L IP + DDAG Y C A N+ G + + G+ +
Sbjct: 264 NGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFR-----------GQLQV 312
Query: 339 TPDPYH----KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPD 394
P+ D + G ++ C+ P T+ W KNG PL R+ +
Sbjct: 313 YTYPHWVEKLNDTQLDSGSPLRWECKATGKPRP--TYRWLKNGVPLSPQSRVEMVNGV-- 368
Query: 395 VSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLV 454
L I ++ +D G Y C+A K G I S ++ I +S P + Q K ++
Sbjct: 369 -------LMIHNVNQSDAGMYQCLAENKYGAIY-ASAELKILASA--PTFALNQLKKTII 418
Query: 455 TREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYR 514
+ + ++C+ G PKP I W + D+ A+ + DG+LRI+N S+ G Y
Sbjct: 419 VTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPDGSLRILNASKSDEGKYV 476
Query: 515 CQTSQYNGFNVKPREALVQLIVQYPPAVE--PAFLEIRQGQDRSVTMSCRVLRAYPIRVL 572
C+ G E + L V+ P +E P E+ G+ S+ ++C+ + + V
Sbjct: 477 CRGENVFG----SAEIIASLSVKEPTRIELTPKRTELTVGE--SIVLNCKAIHDASLDV- 529
Query: 573 TYEWRLGNKLL----RTGQFDS----QEYTEYAVKSLSNENYGVYNCSIINEAG--AGRC 622
T+ W L + + G F+S + ++++ + G Y C + A +
Sbjct: 530 TFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEA 589
Query: 623 SFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQR 682
LV G P V + +L W+ D I +Y L R
Sbjct: 590 ELLVRGPPGPPGI-------VIVEEITESTATLSWSPA-ADNHSPISSYNLQARSPFSLG 641
Query: 683 WWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGD 727
W Q +K I G++ + +L YE R+ G GD
Sbjct: 642 W--QTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGD 684
Score = 41.6 bits (96), Expect = 0.004
Identities = 23/99 (23%), Positives = 47/99 (47%), Gaps = 3/99 (3%)
Query: 23 VYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSAS 82
+YA ++I+ S + + + + + + + + + C G P+P I W K +
Sbjct: 393 IYASAELKILASAPTFALNQLK---KTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVR 449
Query: 83 DRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAI 121
+ + + + + +LRI N + G+Y C+ EN GS I
Sbjct: 450 ENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEI 488
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 130 bits (328), Expect = 4e-30
Identities = 141/578 (24%), Positives = 245/578 (42%), Gaps = 56/578 (9%)
Query: 55 GETLELTCLVTGHPRPQIRWTKT----AGSASDRFQDSSVFNETLRITNIQRHQGGRYYC 110
GE +EL C G P P I+W K A ++R + S+ TL I G+Y C
Sbjct: 3261 GENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSAN-GSTLNIYGALTSDTGKYTC 3319
Query: 111 KAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYS 170
A N G + ++VY P + ++ E K + ++ + C A PP + +
Sbjct: 3320 VATNPAGEED-RIFNLNVYVT--PTIRGNKDEAE-KLMTLVDTSINIECRATGTPPPQIN 3375
Query: 171 WRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKM 230
W L G + + G+ ++++ + D A Y+C+AS N + +K
Sbjct: 3376 W------LKNGLPLPLSSHIRLLAAGQ--VIRIVRAQVSDVAVYTCVAS--NRAGVDNKH 3425
Query: 231 VSFRLSNKTASPSI-KLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRS---FGTLPE 286
+ ++ A P++ + + I V G + ++ C+T G PAPS+ W+R G
Sbjct: 3426 YNLQVF---APPNMDNSMGTEEITVLKGSSTSMACITDG-TPAPSMAWLRDGQPLGLDAH 3481
Query: 287 KTV-LNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHK 345
TV +G L + ++D+G Y+CIA+N G +K + I++ L+ I H+
Sbjct: 3482 LTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSK---HFILKVLEPPH--INGSEEHE 3536
Query: 346 DDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDII 405
+ ++ + ++++C +P+ ++T W K+GRPL ++++ G L I
Sbjct: 3537 EISVIVNNPLELTCIASGIPAPKMT--WMKDGRPLPQTDQV-------QTLGGGEVLRIS 3587
Query: 406 DLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQC 465
+ D G YTC+AS G D V + VPPN+ E + + L+C
Sbjct: 3588 TAQVEDTGRYTCLASSPAGD-DDKEYLVRVH---VPPNIAGTDEPRDITVLRNRQVTLEC 3643
Query: 466 QVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNV 525
+ P P+I W R + E +++ S L+I N + Y C S G
Sbjct: 3644 KSDAVPPPVITWLR-NGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTT 3702
Query: 526 KPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL-- 583
RE + L V PP ++ + ++S + C + P +T WR +L
Sbjct: 3703 --REFI--LTVNVPPNIKGGPQSLVILLNKSTVLEC-IAEGVPTPRIT--WRKDGAVLAG 3755
Query: 584 RTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGR 621
++ E ++S + G Y C N AG R
Sbjct: 3756 NHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDR 3793
Score = 129 bits (323), Expect = 2e-29
Identities = 157/618 (25%), Positives = 269/618 (43%), Gaps = 91/618 (14%)
Query: 23 VYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTK-----T 77
V+ PPT++ SGL SERV + + + + L C+ G P P I W K
Sbjct: 1822 VHVPPTIK--SSGL---------SERV--VVKYKPVALQCIANGIPNPSITWLKDDQPVN 1868
Query: 78 AGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYY---LDDP 134
+ + Q S L+I GRY C A N G + I++ V+ L+D
Sbjct: 1869 TAQGNLKIQSSG---RVLQIAKTLLEDAGRYTCVATNAAGETQ-QHIQLHVHEPPSLEDA 1924
Query: 135 VVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFT 194
+++++ V L C A NP +W + LL GS F
Sbjct: 1925 GKMLNETV-------LVSNPVQLECKAAGNPVPVITWYKDNR-LLSGSTSMT-----FLN 1971
Query: 195 QGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVV 254
+G+ I+ +++ + D Y C+A N + S ++ +PSI ++ + V
Sbjct: 1972 RGQ--IIDIESAQISDAGIYKCVAI--NSAGATELFYSLQVH---VAPSISGS-NNMVAV 2023
Query: 255 NPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT----VLNGGT-LTIPAITSDDAGTYS 309
+ L C G PAPSLTW++ + + VL+GG L + + D G Y+
Sbjct: 2024 VVNNPVRLECEARG-IPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYT 2082
Query: 310 CIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ--IGREVKISCQVEAVPSE 367
C+A N G +K +I +R ++ P+ ++ N+ I + V++ CQ +A+P
Sbjct: 2083 CVAVNAAG---EKQRDIDLRV------YVPPNIMGEEQNVSVLISQAVELLCQSDAIPPP 2133
Query: 368 ELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS 427
LT W K+G PL + +S + L I D + D G YTC A+ G +
Sbjct: 2134 TLT--WLKDGHPLLKKPGL-------SISENRSVLKIEDAQVQDTGRYTCEAT-NVAGKT 2183
Query: 428 DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMP 487
+ + +VNI VPPN+ E + L EG+ I L C+ +G P P ++W + V
Sbjct: 2184 EKNYNVNI---WVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTD 2240
Query: 488 D-GSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV---- 542
G +++ S L+I + + +Y C S G +E +Q+ ++ P +
Sbjct: 2241 SMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAG--TAKKEYNLQVYIR--PTITNSG 2296
Query: 543 -EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRT-GQFDSQEYTEYAVKS 600
P + + +G +S+++ C V + P +T+ + G+ L++ G E +K+
Sbjct: 2297 SHPTEIIVTRG--KSISLECEV-QGIPPPTVTW-MKDGHPLIKAKGVEILDEGHILQLKN 2352
Query: 601 LSNENYGVYNCSIINEAG 618
+ + G Y C +N AG
Sbjct: 2353 IHVSDTGRYVCVAVNVAG 2370
Score = 122 bits (307), Expect = 1e-27
Identities = 127/477 (26%), Positives = 202/477 (42%), Gaps = 66/477 (13%)
Query: 50 YTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYY 109
Y I + + L+C G P P I W K + + + + + +L+I +Q G Y
Sbjct: 4088 YVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYT 4147
Query: 110 CKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYY----ERTVFLRCVANSNP 165
C A N GS + + +TVH + +Y L CVA+ P
Sbjct: 4148 CMAANVAGSSSTST-----------KLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIP 4196
Query: 166 PVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCN 225
+W++ + +L + G EP+ GE L L+N+ +D Y+C+A+ N
Sbjct: 4197 TPAINWKK--DNVLLANLLGKYTAEPY---GE---LILENVVLEDSGFYTCVAN--NAAG 4246
Query: 226 IPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP 285
VS + P+ L D + +N GE + L C T G P P LTW + +P
Sbjct: 4247 EDTHTVSLTVH---VLPTFTELPGD-VSLNKGEQLRLSCKAT-GIPLPKLTWTFNNNIIP 4301
Query: 286 E--KTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPY 343
+V L I ++ +D+GTY C A N+VG V+A+ G ++ P
Sbjct: 4302 AHFDSVNGHSELVIERVSKEDSGTYVCTAENSVG---------FVKAI--GFVYVKEPPV 4350
Query: 344 HKDDNIQ-----IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPG 398
K D +G ++C+V+ P+ T W + G + S R I Q G
Sbjct: 4351 FKGDYPSNWIEPLGGNAILNCEVKGDPTP--TIQWNRKGVDIEISHR--IRQL------G 4400
Query: 399 TTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREG 458
+L I D G YTCVA+ G+ + S+ + + S PP +T+ E V G
Sbjct: 4401 NGSLAIYGTVNEDAGDYTCVAT-NEAGVVERSMSLTLQS---PPIITL--EPVETVINAG 4454
Query: 459 DTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRC 515
I L CQ TG+P+P I WSR ++ D + + +L I + +E + + C
Sbjct: 4455 GKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLS--NNSLYIADAQKEDTSEFEC 4509
Score = 120 bits (302), Expect = 5e-27
Identities = 154/613 (25%), Positives = 237/613 (38%), Gaps = 79/613 (12%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSAS-DRFQDSSVFNETLRITNIQRHQGGRYYC 110
++E +++ LTC VTG+P P+I W K D L+ITN+Q GRY C
Sbjct: 2491 VKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTC 2550
Query: 111 KAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKE-QFYYERTVFLRCVANSNPPVRY 169
A + G + +S ++V+ P + S G ++ L C A S PP
Sbjct: 2551 LASSPAGHKS-RSFSLNVFV--SPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATI 2607
Query: 170 SWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDK 229
+W + L S++ + I G T L++ N + + YSC+A+ N +
Sbjct: 2608 TWFKDGTPL--ESNRNIRI----LPGGRT--LQILNAQEDNAGRYSCVAT-----NEAGE 2654
Query: 230 MVSFRLSNKTASPSIKL-------LVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFG 282
M+ P I L + + +TL C P+ SL+W +
Sbjct: 2655 MIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYA-IPSASLSWYKDGQ 2713
Query: 283 TLPE----KTVLNGGTLTIPAITSDDAGTYSCIANNNVGN------------PAKKSTNI 326
L NG TL I D G Y+C+A+N G P+ +
Sbjct: 2714 PLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWE 2773
Query: 327 IVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERM 386
I L GR D + I + + C+ A P LT W+K+G PL SS+++
Sbjct: 2774 IGNMLDTGRNGEAKD-------VIINNPISLYCETNAAPPPTLT--WYKDGHPLTSSDKV 2824
Query: 387 VITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPP---- 442
+I PG L I K D G YTCVA + G + DV + VPP
Sbjct: 2825 LIL-------PGGRVLQIPRAKVEDAGRYTCVA-VNEAGEDSLQYDVRV---LVPPIIKG 2873
Query: 443 -NLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLR 501
N +P+E + LV + ++C +G P P W + D + + D + S L+
Sbjct: 2874 ANSDLPEEVTVLVNKSA---LIECLSSGSPAPRNSWQK-DGQPLLEDDHHKFLSNGRILQ 2929
Query: 502 IVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV-EPAFLEIRQGQDRSVTMS 560
I+N G Y C G K L V PP+V P + + ++++
Sbjct: 2930 ILNTQITDIGRYVCVAENTAGSAKK----YFNLNVHVPPSVIGPKSENLTVVVNNFISLT 2985
Query: 561 CRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAG 620
C V +P L++ L T + + G Y C IN+AG
Sbjct: 2986 CEV-SGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGES 3044
Query: 621 RCSFLVTGKAYAP 633
+ F +T Y P
Sbjct: 3045 KKKFSLT--VYVP 3055
Score = 120 bits (301), Expect = 6e-27
Identities = 138/525 (26%), Positives = 215/525 (40%), Gaps = 88/525 (16%)
Query: 23 VYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSAS 82
V+APP++ I R E + + E ++ LTC +G P P I W K S
Sbjct: 2380 VHAPPSI----------IGNHRSPENISVV-EKNSVSLTCEASGIPLPSITWFKDGWPVS 2428
Query: 83 DRFQDSSVF----NETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTV 138
+SV LR+ G+Y C N G K + V L P +
Sbjct: 2429 ---LSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEER-KIFGLSV--LVPPHIVG 2482
Query: 139 HQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGET 198
++ + K + +++V L C NP +W + + L + E
Sbjct: 2483 ENTLEDVKVK--EKQSVTLTCEVTGNPVPEITWHKDGQPLQED--------EAHHIISGG 2532
Query: 199 KILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDD----PIVV 254
+ L++ N++ Y+C+AS K SF L N SP+I + D + V
Sbjct: 2533 RFLQITNVQVPHTGRYTCLAS----SPAGHKSRSFSL-NVFVSPTIAGVGSDGNPEDVTV 2587
Query: 255 NPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT----VLNGG-TLTIPAITSDDAGTYS 309
+LVC PA ++TW + GT E +L GG TL I D+AG YS
Sbjct: 2588 ILNSPTSLVCEAYSYPPA-TITWFKD-GTPLESNRNIRILPGGRTLQILNAQEDNAGRYS 2645
Query: 310 CIANNNVGNPAK--KSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSE 367
C+A N G K + I + KG W P K+ I++ + + C+ A+PS
Sbjct: 2646 CVATNEAGEMIKHYEVKVYIPPIINKGDLW-GPGLSPKEVKIKVNNTLTLECEAYAIPSA 2704
Query: 368 ELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS 427
L SW+K+G+PL+S + + +++ L I + + +D G YTCVAS G
Sbjct: 2705 SL--SWYKDGQPLKSDDHV-------NIAANGHTLQIKEAQISDTGRYTCVAS-NIAGED 2754
Query: 428 DISIDVNISSSTVPPNLTVPQEKSPLVT--REGDT--------IELQCQVTGKPKPIILW 477
++ DVNI VPP+ E ++ R G+ I L C+ P P + W
Sbjct: 2755 ELDFDVNIQ---VPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTW 2811
Query: 478 -------SRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRC 515
+ +DK + +P G + L+I E +G Y C
Sbjct: 2812 YKDGHPLTSSDKVLILPGGRV--------LQIPRAKVEDAGRYTC 2848
Score = 119 bits (297), Expect = 2e-26
Identities = 150/591 (25%), Positives = 244/591 (41%), Gaps = 80/591 (13%)
Query: 60 LTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF--NETLRITNIQRHQGGRYYCKAENGLG 117
L C +P I W K G+ + ++ + TL+I N Q GRY C A N G
Sbjct: 2595 LVCEAYSYPPATITWFKD-GTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAG 2653
Query: 118 SPAIKSIRVDVYYLDDPVVTVHQSIGEA----KEQFYYERTVFLRCVANSNPPVRYSWRR 173
IK V VY P++ G + + T+ L C A + P SW +
Sbjct: 2654 E-MIKHYEVKVYI--PPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYK 2710
Query: 174 GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSF 233
+ L SD V I G T L++K + D Y+C+AS N+ + + F
Sbjct: 2711 DGQPLK--SDDHVNIA----ANGHT--LQIKEAQISDTGRYTCVAS--NIAG--EDELDF 2758
Query: 234 RLSNKTASPSIKLLVD--------------DPIVVNPGEAITLVCVTTGGEPAPSLTWVR 279
+ N PS + L + D I+ NP I+L C T P P+LTW +
Sbjct: 2759 DV-NIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNP---ISLYCETNAAPP-PTLTWYK 2813
Query: 280 SFGTLPEKT---VLNGG-TLTIPAITSDDAGTYSCIANNNVGNPA-KKSTNIIVRALKKG 334
L +L GG L IP +DAG Y+C+A N G + + ++V + KG
Sbjct: 2814 DGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKG 2873
Query: 335 RFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPD 394
P+ + + + + I C P+ SW K+G+PL +
Sbjct: 2874 ANSDLPE----EVTVLVNKSALIECLSSGSPAPR--NSWQKDGQPLLEDDHHKF------ 2921
Query: 395 VSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLV 454
+S G L I++ + TD G Y CVA G ++N+ VPP++ P+ ++ L
Sbjct: 2922 LSNGRI-LQILNTQITDIGRYVCVAENTAGSAKKY-FNLNVH---VPPSVIGPKSEN-LT 2975
Query: 455 TREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYR 514
+ I L C+V+G P P + W + ++ + + ++ + TL+I+ G Y
Sbjct: 2976 VVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG-GRTLQIIRAKVSDGGEYT 3034
Query: 515 CQTSQYNGFNVKPREALVQLIVQYPPAVEP------AFLEIRQGQDRSVTMSCRVLRAYP 568
C G + K L V PP+++ + + +R+G SV++ C A P
Sbjct: 3035 CIAINQAGESKKK----FSLTVYVPPSIKDHDSESLSVVNVREG--TSVSLECE-SNAVP 3087
Query: 569 IRVLTYEWRLGNKLLRTGQFD-SQEYTEYAVKSLSNENYGVYNCSIINEAG 618
V+T+ ++ G + + + + +K + G Y C IN AG
Sbjct: 3088 PPVITW-YKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAG 3137
Score = 117 bits (294), Expect = 4e-26
Identities = 130/548 (23%), Positives = 224/548 (40%), Gaps = 88/548 (16%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAEN 114
G + + C TG+P+P+I WT + + TL I N G Y C A N
Sbjct: 626 GSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASN 685
Query: 115 GLGSPAIKSIRVDVYYLDDPVVTVHQS-----IGEAKEQFYYERTVFLRCVANSNPPVRY 169
G+ S + Y++ P + V QS +G+ + C + PP +
Sbjct: 686 SAGTDKQNST---LRYIEAPKLMVVQSELLVALGDI---------TVMECKTSGIPPPQV 733
Query: 170 SWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDK 229
W +G L+ I +P +LK++ + D +Y+C+A N +
Sbjct: 734 KWFKGD---LELRPSTFLIIDPLLG-----LLKIQETQDLDAGDYTCVA-----INEAGR 780
Query: 230 MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP---- 285
+++ SP + + + + G +TL C G P P++ W R +P
Sbjct: 781 ATG-KITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQG-YPEPTIKW-RRLDNMPIFSR 837
Query: 286 -----EKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITP 340
+ L G L I + + D GTY C A N G + T + V L I+P
Sbjct: 838 PFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGK-IQSETTVTVTGLVAPLIGISP 896
Query: 341 DPYHKDDNIQIGREVKISCQVEA---VPSEELTFSWFKNGRPLRSSERMVITQTDPDVSP 397
N+ G+++ + C + A +P W KN L + + + S
Sbjct: 897 SVA----NVIEGQQLTLPCTLLAGNPIPERR----WIKNSAMLLQNPYITVR------SD 942
Query: 398 GTTNLDIIDLKFTDFGTYTCVAS-LKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTR 456
G+ +++ + L+ D G YTCVAS + G S+ V++ T+ + L T
Sbjct: 943 GSLHIERVQLQ--DGGEYTCVASNVAGTNNKTTSVVVHVLP-------TIQHGQQILSTI 993
Query: 457 EGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQ 516
EG + L C+ +G PKP ++WS+ + ++ + DG+L +V+ E SG Y C
Sbjct: 994 EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGA-DGSLYVVSPGGEESGEYVCT 1052
Query: 517 TSQYNGFNVKPREALVQLIVQYPPAV----------EPAFLEIRQGQDRSVTMSCRVLRA 566
+ G+ + VQL V P V +P + + G++ VT+ C V ++
Sbjct: 1053 ATNTAGY----AKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEE--VTLPCEV-KS 1105
Query: 567 YPIRVLTY 574
P ++T+
Sbjct: 1106 LPPPIITW 1113
Score = 114 bits (286), Expect = 3e-25
Identities = 148/581 (25%), Positives = 223/581 (38%), Gaps = 90/581 (15%)
Query: 60 LTCLVTGHPRPQIRWTKTAGSAS-DRFQDSS--VFNETLRITNIQRHQGGRYYCKAENGL 116
L C TG P+P I W K + D+ Q+S + + +L I + Y C NG
Sbjct: 3823 LACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGA 3882
Query: 117 GSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYER--TVFLRCVANSNPPVRYSWRRG 174
G D D V V SI + F + + C A+ P W +
Sbjct: 3883 G---------DDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKN 3933
Query: 175 QEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFR 234
LL D G I + G +IL + Y+C+A RN
Sbjct: 3934 GIRLLPRGD-GYRI----LSSGAIEILATQL---NHAGRYTCVA--RNAAG--------- 3974
Query: 235 LSNKTASPSIKLLVDDPIVVNP---------GEAITLVCVTTGGEPAPSLTW------VR 279
+A + L V +P V+ P I L C TG P+P +TW V
Sbjct: 3975 ----SAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATG-TPSPFITWQKEGINVN 4029
Query: 280 SFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNP-AKKSTNIIVRALKKGRFWI 338
+ G VL G L I +DAGTY C+A N G K N+ V +
Sbjct: 4030 TSGR--NHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPV------- 4080
Query: 339 TPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPG 398
P+ K+ I + + + +SC+ + +P ++T W K+GR + S R + +
Sbjct: 4081 -ISPHLKEYVIAVDKPITLSCEADGLPPPDIT--WHKDGRAIVESIRQRVLSSG------ 4131
Query: 399 TTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREG 458
+L I ++ D G YTC+A+ G S S + + VPP + + E
Sbjct: 4132 --SLQIAFVQPGDAGHYTCMAA-NVAGSSSTSTKLTVH---VPPR--IRSTEGHYTVNEN 4183
Query: 459 DTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTS 518
L C G P P I W + + +A G E Y G L + NV E SG Y C +
Sbjct: 4184 SQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPY-GELILENVVLEDSGFYTCVAN 4242
Query: 519 QYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRL 578
G + V L V P ++ + + +SC+ P+ LT W
Sbjct: 4243 NAAGEDTH----TVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKA-TGIPLPKLT--WTF 4295
Query: 579 GNKLLRTGQFDS-QEYTEYAVKSLSNENYGVYNCSIINEAG 618
N ++ FDS ++E ++ +S E+ G Y C+ N G
Sbjct: 4296 NNNII-PAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVG 4335
Score = 114 bits (284), Expect = 6e-25
Identities = 136/591 (23%), Positives = 237/591 (40%), Gaps = 58/591 (9%)
Query: 44 RYSERVYTIREGETLELTCLVTGHPRPQIRWTKTA---GSASDRFQDSSVFNETLRITNI 100
++ +++ + EG + L C +G+P+P + W+K ++S +F S+ + +L + +
Sbjct: 984 QHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKF--SAGADGSLYVVSP 1041
Query: 101 QRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKE---QFYYERTVFL 157
+ G Y C A N G A + +++ V Y+ V + + + K V L
Sbjct: 1042 GGEESGEYVCTATNTAGY-AKRKVQLTV-YVRPRVFGDQRGLSQDKPVEISVLAGEEVTL 1099
Query: 158 RCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCI 217
C S PP +W + ++ + + P T + +K+ R D Y C+
Sbjct: 1100 PCEVKSLPPPIITWAKETQL--------ISPFSPRHTFLPSGSMKITETRTSDSGMYLCV 1151
Query: 218 ASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTW 277
A+ NI + N P I+ + V G+ + + C G P P +TW
Sbjct: 1152 AT-----NIAGNVTQAVKLNVHVPPKIQ-RGPKHLKVQVGQRVDIPC-NAQGTPLPVITW 1204
Query: 278 VRSFGTL---PEKTVLN-GGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKK 333
+ T+ E V N GTL+I T DAG Y+C+A N G T I + +
Sbjct: 1205 SKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGT---DETEITLHVQEP 1261
Query: 334 GRFWITPDPYHKDDNIQIGRE-VKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTD 392
PY+ ++ + ++ C + P T W NGR L E + D
Sbjct: 1262 PTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKP--TIKWLHNGRELTGREPGISILED 1319
Query: 393 PDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSP 452
T L I + D G Y CVA + G ++ ++ + VPP + ++ +
Sbjct: 1320 ------GTLLVIASVTPYDNGEYICVA-VNEAGTTERKYNLKVH---VPPVIKDKEQVTN 1369
Query: 453 LVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGM 512
+ L C+V G P PII+W + + +V ++Q + L++ + E +G
Sbjct: 1370 VSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVT-ESSTIQTVNNGKILKLFRATPEDAGR 1428
Query: 513 YRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFL--EIRQGQDRSVTMSCRVLRAYPIR 570
Y C+ G + K + V PP + E+ +R V + C+V + P
Sbjct: 1429 YSCKAINIAGTSQK----YFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQV-KGTPFP 1483
Query: 571 VLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSN---ENYGVYNCSIINEAG 618
+ W K L G + + V L N + G Y C++ N AG
Sbjct: 1484 DI--HWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAG 1532
Score = 113 bits (282), Expect = 1e-24
Identities = 132/594 (22%), Positives = 240/594 (40%), Gaps = 68/594 (11%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF--NETLRITNIQRHQGGRY 108
++ GE + L C V P P I W K S F F + +++IT + G Y
Sbjct: 1090 SVLAGEEVTLPCEVKSLPPPIITWAKETQLISP-FSPRHTFLPSGSMKITETRTSDSGMY 1148
Query: 109 YCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
C A N G+ ++++++V+ V G + + V + C A P
Sbjct: 1149 LCVATNIAGN-VTQAVKLNVH------VPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPV 1201
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
+W +G +L + V L + P D Y+C+A+ N+ +
Sbjct: 1202 ITWSKGGSTMLVDGEHHVS--------NPDGTLSIDQATPSDAGIYTCVAT--NIAGTDE 1251
Query: 229 KMVSFRLSN----KTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRS---- 280
++ + + P + + + I C G P P++ W+ +
Sbjct: 1252 TEITLHVQEPPTVEDLEPPYNTTFQERVA---NQRIEFPCPAKG-TPKPTIKWLHNGREL 1307
Query: 281 FGTLPEKTVLNGGTL-TIPAITSDDAGTYSCIANNNVGNPAKK-STNIIVRALKKGRFWI 338
G P ++L GTL I ++T D G Y C+A N G +K + + V + K + +
Sbjct: 1308 TGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQV 1367
Query: 339 TPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPG 398
T + ++ + + + C+VE PS + W+K+ + S T V+ G
Sbjct: 1368 T------NVSVLLNQLTNLFCEVEGTPSPIIM--WYKDNVQVTESS------TIQTVNNG 1413
Query: 399 TTNLDIIDLKFTDFGTYTCVA-SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTRE 457
L + D G Y+C A ++ G +IDV + + + N P E S ++ R+
Sbjct: 1414 KI-LKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNF--PNEVSVVLNRD 1470
Query: 458 GDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQT 517
+ L+CQV G P P I W + K + + D ++++ L + N R G Y+C
Sbjct: 1471 ---VALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTV 1527
Query: 518 SQYNGFNVKPREALVQLIVQYPPAVEPAFL--EIRQGQDRSVTMSCRVLRAYPIRVLTYE 575
S G K ++L + PP+++ + +I + + + C R P+ +T+
Sbjct: 1528 SNAAGKQAKD----IKLTIYIPPSIKGGNVTTDISVLINSLIKLECET-RGLPMPAITW- 1581
Query: 576 WRLGNKLLRTGQ---FDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLV 626
++ G ++ + Q D +Y +S+ Y C + N AG SF V
Sbjct: 1582 YKDGQPIMSSSQALYIDKGQYLHIPRAQVSDS--ATYTCHVANVAGTAEKSFHV 1633
Score = 112 bits (279), Expect = 2e-24
Identities = 113/483 (23%), Positives = 193/483 (39%), Gaps = 55/483 (11%)
Query: 50 YTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFN-ETLRITNIQRHQGGRY 108
+ + LEL C VTG P P I W K +R + N L I Q G Y
Sbjct: 1744 FIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLY 1803
Query: 109 YCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
C A N G K V V+ V +S G ++ + V L+C+AN P
Sbjct: 1804 RCMAANTAGDHK-KEFEVTVH-----VPPTIKSSGLSERVVVKYKPVALQCIANGIPNPS 1857
Query: 169 YSWRRGQEVL--LQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNI 226
+W + + + QG+ K Q ++L++ +D Y+C+A+ N
Sbjct: 1858 ITWLKDDQPVNTAQGNLK---------IQSSGRVLQIAKTLLEDAGRYTCVAT--NAAGE 1906
Query: 227 PDKMVSFRLSN-KTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP 285
+ + + + + K+L + +V NP + L C G P P +TW + L
Sbjct: 1907 TQQHIQLHVHEPPSLEDAGKMLNETVLVSNP---VQLEC-KAAGNPVPVITWYKDNRLLS 1962
Query: 286 EKTVL----NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPD 341
T + G + I + DAG Y C+A N+ G +T + + + P
Sbjct: 1963 GSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAG-----ATELFYSL----QVHVAPS 2013
Query: 342 PYHKDDNIQ--IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGT 399
++ + + V++ C+ +P+ LT W K+G P+ S + V G
Sbjct: 2014 ISGSNNMVAVVVNNPVRLECEARGIPAPSLT--WLKDGSPVSSFSNGL------QVLSGG 2065
Query: 400 TNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGD 459
L + + +D G YTCVA + G ID+ + VPPN+ ++ ++ +
Sbjct: 2066 RILALTSAQISDTGRYTCVA-VNAAGEKQRDIDLRV---YVPPNIMGEEQNVSVLISQ-- 2119
Query: 460 TIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQ 519
+EL CQ P P + W + D + + + L+I + + +G Y C+ +
Sbjct: 2120 AVELLCQSDAIPPPTLTWLK-DGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATN 2178
Query: 520 YNG 522
G
Sbjct: 2179 VAG 2181
Score = 107 bits (267), Expect = 5e-23
Identities = 133/562 (23%), Positives = 218/562 (38%), Gaps = 65/562 (11%)
Query: 23 VYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSAS 82
V PP ++ +S L + T+ ++ + CL +G P P+ W K
Sbjct: 2865 VLVPPIIKGANSDLPEEV----------TVLVNKSALIECLSSGSPAPRNSWQKDGQPLL 2914
Query: 83 DRFQDSSVFN-ETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQS 141
+ + N L+I N Q GRY C AEN GS A K ++V+ + ++
Sbjct: 2915 EDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGS-AKKYFNLNVHVPPSVIGPKSEN 2973
Query: 142 IGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKIL 201
+ F + L C + PP SW + ++ + ++ + G T L
Sbjct: 2974 LTVVVNNF-----ISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLI------VPGGRT--L 3020
Query: 202 KLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPI-VVN--PGE 258
++ + D Y+CIA N K S + PSIK + + VVN G
Sbjct: 3021 QIIRAKVSDGGEYTCIAI--NQAGESKKKFSLTVY---VPPSIKDHDSESLSVVNVREGT 3075
Query: 259 AITLVCVTTGGEPAPSLTWVRSFGTLPEKT----VLNGGTLTIPAITSDDAGTYSCIANN 314
+++L C + P P +TW ++ + E T + +G L I D G Y C A N
Sbjct: 3076 SVSLEC-ESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAIN 3134
Query: 315 NVGNPAKK-STNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSW 373
G K N+ V +G P + I V ++C +P T +W
Sbjct: 3135 VAGRDDKNFHLNVYVPPSIEG-------PEREVIVETISNPVTLTCDATGIPPP--TIAW 3185
Query: 374 FKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDV 433
KN + + +S+ + + + G + L I + +D G YTC+AS G
Sbjct: 3186 LKNHKRIENSDSLEVR-----ILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYF-- 3238
Query: 434 NISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQM 493
S VPP++ + S + G+ +EL C G P P+I W + K +A +
Sbjct: 3239 --LSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIR 3296
Query: 494 ESYDG-TLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQG 552
S +G TL I +G Y C + G + + L V P + E +
Sbjct: 3297 VSANGSTLNIYGALTSDTGKYTCVATNPAG----EEDRIFNLNVYVTPTIRGNKDEAEKL 3352
Query: 553 Q---DRSVTMSCRVLRAYPIRV 571
D S+ + CR P ++
Sbjct: 3353 MTLVDTSINIECRATGTPPPQI 3374
Score = 105 bits (262), Expect = 2e-22
Identities = 145/593 (24%), Positives = 230/593 (38%), Gaps = 70/593 (11%)
Query: 47 ERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNET-LRITNIQRHQG 105
E+ ++ + +EL C P P + W K + S N + L+I + Q
Sbjct: 2110 EQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDT 2169
Query: 106 GRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYE----RTVFLRCVA 161
GRY C+A N G K+ V+++ V +IG + E + L C +
Sbjct: 2170 GRYTCEATNVAGKTE-KNYNVNIW--------VPPNIGGSDELTQLTVIEGNLISLLCES 2220
Query: 162 NSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVR 221
+ PP W++ +L S V I + L++ D A YSC+AS
Sbjct: 2221 SGIPPPNLIWKKKGSPVLTDSMGRVRILSG------GRQLQISIAEKSDAALYSCVAS-- 2272
Query: 222 NVCNIPDKMVSFRLSNKTASPSIKLLVDDP--IVVNPGEAITLVCVTTGGEPAPSLTWVR 279
NV K + ++ + P+I P I+V G++I+L C G P P++TW++
Sbjct: 2273 NVAGTAKKEYNLQVYIR---PTITNSGSHPTEIIVTRGKSISLECEVQG-IPPPTVTWMK 2328
Query: 280 SFGTLPE----KTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGR 335
L + + + G L + I D G Y C+A N G KK ++ V A
Sbjct: 2329 DGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKY-DLSVHAPPS-- 2385
Query: 336 FWITPDPYHKDDNIQIGRE--VKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDP 393
+ +NI + + V ++C+ +P +T WFK+G P+ S + I
Sbjct: 2386 ---IIGNHRSPENISVVEKNSVSLTCEASGIPLPSIT--WFKDGWPVSLSNSVRILS--- 2437
Query: 394 DVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPL 453
G L ++ D G YTCV G I S VPP++ +
Sbjct: 2438 ----GGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFG----LSVLVPPHIVGENTLEDV 2489
Query: 454 VTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMY 513
+E ++ L C+VTG P P I W + D + D + + S L+I NV +G Y
Sbjct: 2490 KVKEKQSVTLTCEVTGNPVPEITWHK-DGQPLQEDEAHHIISGGRFLQITNVQVPHTGRY 2548
Query: 514 RCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEI-RQGQDRSVTM-----SCRVLRAY 567
C S G K R + + V P + G VT+ + V AY
Sbjct: 2549 TCLASSPAGH--KSRSFSLNVF------VSPTIAGVGSDGNPEDVTVILNSPTSLVCEAY 2600
Query: 568 PIRVLTYEWRLGNKLLRTGQFDS--QEYTEYAVKSLSNENYGVYNCSIINEAG 618
T W L + + + + +N G Y+C NEAG
Sbjct: 2601 SYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAG 2653
Score = 104 bits (259), Expect = 4e-22
Identities = 140/590 (23%), Positives = 226/590 (38%), Gaps = 93/590 (15%)
Query: 60 LTCLVTGHPRPQIRWTKTA-----GSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAEN 114
L C V G P P I W K G + D + L + N +R+ GRY C N
Sbjct: 1473 LECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRG---QVLHLKNARRNDKGRYQCTVSN 1529
Query: 115 GLGSPAIKSIRVDVYY---LDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSW 171
G A K I++ +Y + VT S+ + L C P +W
Sbjct: 1530 AAGKQA-KDIKLTIYIPPSIKGGNVTTDISV-------LINSLIKLECETRGLPMPAITW 1581
Query: 172 RRGQEVLLQGS-----DKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNI 226
+ + ++ S DKG ++ P + D A Y+C V NV
Sbjct: 1582 YKDGQPIMSSSQALYIDKGQYLHIP-------------RAQVSDSATYTC--HVANVAGT 1626
Query: 227 PDKMVSFRLSNKTASPSIKLLVDDPI--VVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL 284
+K SF + + P I+ + P+ V ++TL C G P+P LTW++ +
Sbjct: 1627 AEK--SFHV-DVYVPPMIEGNLATPLNKQVVIAHSLTLEC-KAAGNPSPILTWLKD--GV 1680
Query: 285 PEKTVLN------GGTLTIPAITSDDAGTYSCIANNNVGNPA-KKSTNIIVRALKKG--- 334
P K N G L I + D G Y C+A + G K +++V +G
Sbjct: 1681 PVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDE 1740
Query: 335 -RFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDP 393
++I + + +++ C V P T W K+G+ + + I
Sbjct: 1741 TSYFI----------VMVNNLLELDCHVTGSPPP--TIMWLKDGQLIDERDGFKILLNG- 1787
Query: 394 DVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPL 453
L I + ++ G Y C+A+ G +V + VPP + +
Sbjct: 1788 ------RKLVIAQAQVSNTGLYRCMAANTAGDHKK-EFEVTVH---VPPTIKSSGLSERV 1837
Query: 454 VTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMY 513
V + + LQC G P P I W + D+ V G+++++S L+I E +G Y
Sbjct: 1838 VVKY-KPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRY 1896
Query: 514 RCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQG--QDRSVTMSCRVLRAYPIRV 571
C + G + +QL V PP++E A + + V + C+ P+ V
Sbjct: 1897 TCVATNAAG----ETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKA-AGNPVPV 1951
Query: 572 LTYEWRLGNKLL--RTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGA 619
+T W N+LL T ++S + G+Y C IN AGA
Sbjct: 1952 IT--WYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGA 1999
Score = 102 bits (255), Expect = 1e-21
Identities = 146/587 (24%), Positives = 232/587 (39%), Gaps = 86/587 (14%)
Query: 60 LTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNE-TLRITNIQRHQGGRYYCKAENGLGS 118
+TC +G P P I WTK R + + + I Q + GRY C A N GS
Sbjct: 3916 ITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGS 3975
Query: 119 PAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRR-GQEV 177
A + + + V+ + PV+ S + + L C A P +W++ G V
Sbjct: 3976 -AHRHVTLHVH--EPPVIQPQPS----ELHVILNNPILLPCEATGTPSPFITWQKEGINV 4028
Query: 178 LLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSN 237
G + V G +I + +D Y C+A +N
Sbjct: 4029 NTSGRNHAV------LPSGGLQISRAVR---EDAGTYMCVA--QNPAG------------ 4065
Query: 238 KTASPSIKLLVDDPIVVNP---------GEAITLVCVTTGGEPAPSLTWVRSFGTLPE-- 286
TA IKL V P V++P + ITL C G P P +TW + + E
Sbjct: 4066 -TALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSC-EADGLPPPDITWHKDGRAIVESI 4123
Query: 287 -KTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHK 345
+ VL+ G+L I + DAG Y+C+A N G+ + ST + V + R T Y
Sbjct: 4124 RQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGS-SSTSTKLTVHVPPRIRS--TEGHYTV 4180
Query: 346 DDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDII 405
++N Q + C + +P+ + +W K+ L + + + L +
Sbjct: 4181 NENSQ----AILPCVADGIPTPAI--NWKKDNVLLANLLGKYTAEPYGE-------LILE 4227
Query: 406 DLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQC 465
++ D G YTCVA+ G D + S TV T + + +G+ + L C
Sbjct: 4228 NVVLEDSGFYTCVANNAAGE------DTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSC 4281
Query: 466 QVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNV 525
+ TG P P + W+ + + S+ S L I VS+E SG Y C GF
Sbjct: 4282 KATGIPLPKLTWTFNNNIIPAHFDSVNGHS---ELVIERVSKEDSGTYVCTAENSVGFV- 4337
Query: 526 KPREALVQLIVQYPPAVEPAF----LEIRQGQDRSVTMSCRVLRAYPIRVLTYEW-RLGN 580
+A+ + V+ PP + + +E G + ++C V + P T +W R G
Sbjct: 4338 ---KAIGFVYVKEPPVFKGDYPSNWIEPLGG---NAILNCEV-KGDPTP--TIQWNRKGV 4388
Query: 581 KLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 627
+ + + A+ NE+ G Y C NEAG S +T
Sbjct: 4389 DIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLT 4435
Score = 100 bits (250), Expect = 5e-21
Identities = 138/614 (22%), Positives = 241/614 (39%), Gaps = 85/614 (13%)
Query: 23 VYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSAS 82
V+APP N++ +E + T+ +G + + C+ G P P + W +
Sbjct: 3430 VFAPP-----------NMDNSMGTEEI-TVLKGSSTSMACITDGTPAPSMAWLRDGQPLG 3477
Query: 83 -DRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQS 141
D S L++ + G+Y C A N G V +++ + H +
Sbjct: 3478 LDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAG-------EVSKHFILKVLEPPHIN 3530
Query: 142 IGEAKEQF--YYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETK 199
E E+ + L C+A+ P + +W + L Q + T G +
Sbjct: 3531 GSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQ--------TDQVQTLGGGE 3582
Query: 200 ILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDP--IVVNPG 257
+L++ + +D Y+C+AS + + +V + A D+P I V
Sbjct: 3583 VLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAG------TDEPRDITVLRN 3636
Query: 258 EAITLVCVTTGGEPAPSLTWVRSFGTL---PEKTVLNGGT-LTIPAITSDDAGTYSCIAN 313
+TL C + P P +TW+R+ L P +L+GG L I D Y+C+A+
Sbjct: 3637 RQVTLEC-KSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVAS 3695
Query: 314 NNVGNPAKK--STNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTF 371
N G ++ T + +K G + I + + + C E VP+ +T
Sbjct: 3696 NIAGKTTREFILTVNVPPNIKGGPQSLV---------ILLNKSTVLECIAEGVPTPRIT- 3745
Query: 372 SWFKNGRPLRSSE-RMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDIS 430
W K+G L + R I + L I TD G Y C+A+ G
Sbjct: 3746 -WRKDGAVLAGNHARYSILENG--------FLHIQSAHVTDTGRYLCMAT-NAAGTDRRR 3795
Query: 431 IDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADK--EVAMPD 488
ID+ + VPP++ ++ T L C+ TG PKP I W + V
Sbjct: 3796 IDLQVH---VPPSIAPGPTNMTVIVNVQTT--LACEATGIPKPSINWRKNGHLLNVDQNQ 3850
Query: 489 GSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLE 548
S ++ S G+L I++ S + + Y C + G + + V L VQ PP++ +
Sbjct: 3851 NSYRLLS-SGSLVIISPSVDDTATYECTVTNGAGDD----KRTVDLTVQVPPSIADEPTD 3905
Query: 549 IRQGQDRSVTMSCRVLRAYPIRVLTYEW-RLGNKLLRTGQFDSQEYTEYAVKSLSNE--N 605
+ ++C A + + W + G +LL G + + A++ L+ + +
Sbjct: 3906 FLVTKHAPAVITC---TASGVPFPSIHWTKNGIRLLPRGD-GYRILSSGAIEILATQLNH 3961
Query: 606 YGVYNCSIINEAGA 619
G Y C N AG+
Sbjct: 3962 AGRYTCVARNAAGS 3975
Score = 97.8 bits (242), Expect = 4e-20
Identities = 140/585 (23%), Positives = 233/585 (39%), Gaps = 73/585 (12%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSA--SDRFQDSSVFNETLRITNIQRHQGGRY 108
T+ GE LTCL+ + W + ++ + ++ N +L + +++ + G Y
Sbjct: 530 TVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEY 589
Query: 109 YCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
+C + GS A V + + P VTV + F V + C A P +
Sbjct: 590 HCMVSSEGGSSAAS---VFLTVQEPPKVTVMPK----NQSFTGGSEVSIMCSATGYPKPK 642
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
+W ++ + GS + + L +KN P+D Y C+AS N
Sbjct: 643 IAW-TVNDMFIVGSHR--------YRMTSDGTLFIKNAAPKDAGIYGCLAS--NSAGTDK 691
Query: 229 KMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT 288
+ + R +P + ++V ++V G+ + C T G P P + W + L T
Sbjct: 692 QNSTLRY---IEAPKL-MVVQSELLVALGDITVMEC-KTSGIPPPQVKWFKGDLELRPST 746
Query: 289 VL----NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH 344
L G L I DAG Y+C+A N G K T L G +P +
Sbjct: 747 FLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKIT------LDVG----SPPVFI 796
Query: 345 K---DDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSP---- 397
+ D +++IG V + C V+ P E T W R + M I VS
Sbjct: 797 QEPADVSMEIGSNVTLPCYVQGYP--EPTIKW-------RRLDNMPIFSRPFSVSSISQL 847
Query: 398 GTTNLDIIDLKFTDFGTYTCVASLKGGGI-SDISIDVNISSSTVPPNLTVPQEKSPLVTR 456
T L I++L +D GTY C A + G I S+ ++ V + V P + + + ++
Sbjct: 848 RTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV---TGLVAPLIGISPSVANVI-- 902
Query: 457 EGDTIELQCQ-VTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRC 515
EG + L C + G P P W + + + + + + + S DG+L I V + G Y C
Sbjct: 903 EGQQLTLPCTLLAGNPIPERRWIK-NSAMLLQNPYITVRS-DGSLHIERVQLQDGGEYTC 960
Query: 516 QTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYE 575
S G N K +V ++ P ++ + + VT+ C+ V+
Sbjct: 961 VASNVAGTNNKTTSVVVHVL----PTIQHGQQILSTIEGIPVTLPCKASGNPKPSVI--- 1013
Query: 576 WRLGNKLLRT--GQFDSQEYTEYAVKSLSNENYGVYNCSIINEAG 618
W +L+ T +F + V S E G Y C+ N AG
Sbjct: 1014 WSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAG 1058
Score = 90.1 bits (222), Expect = 9e-18
Identities = 138/625 (22%), Positives = 236/625 (37%), Gaps = 107/625 (17%)
Query: 23 VYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTK--TAGS 80
VY PP ++ LA + ++ + +L L C G+P P + W K
Sbjct: 1635 VYVPP---MIEGNLATPLNKQ--------VVIAHSLTLECKAAGNPSPILTWLKDGVPVK 1683
Query: 81 ASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQ 140
A+D + + L I + Q G+Y C A + G IK Y +D V V
Sbjct: 1684 ANDNIR-IEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIK------YEVD---VLVPP 1733
Query: 141 SIGEAKEQFYY----ERTVFLRCVANSNPPVRYSW---------RRGQEVLLQGSDKGVE 187
+I E Y+ + L C +PP W R G ++LL G
Sbjct: 1734 AIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNG------ 1787
Query: 188 IYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLL 247
+ L + + + Y C+A+ N D F ++ P+IK
Sbjct: 1788 -----------RKLVIAQAQVSNTGLYRCMAA--NTAG--DHKKEFEVT-VHVPPTIKSS 1831
Query: 248 VDDPIVVNPGEAITLVCVTTGGEPAPSLTWVR-------SFGTLPEKTVLNGGTLTIPAI 300
VV + + L C+ G P PS+TW++ + G L K +G L I
Sbjct: 1832 GLSERVVVKYKPVALQCI-ANGIPNPSITWLKDDQPVNTAQGNL--KIQSSGRVLQIAKT 1888
Query: 301 TSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKD------DNIQIGRE 354
+DAG Y+C+A N G + + + P +D + + +
Sbjct: 1889 LLEDAGRYTCVATNAAGETQQHI-----------QLHVHEPPSLEDAGKMLNETVLVSNP 1937
Query: 355 VKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGT 414
V++ C+ P +T W+K+ R L S M + DI + +D G
Sbjct: 1938 VQLECKAAGNPVPVIT--WYKDNRLLSGSTSMTFLNRGQII-------DIESAQISDAGI 1988
Query: 415 YTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPI 474
Y CVA + G +++ + + V P+++ +V + + L+C+ G P P
Sbjct: 1989 YKCVA-INSAGATELFYSLQVH---VAPSISGSNNMVAVVV--NNPVRLECEARGIPAPS 2042
Query: 475 ILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQL 534
+ W + V+ +Q+ S L + + +G Y C N K R+ + L
Sbjct: 2043 LTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVA--VNAAGEKQRD--IDL 2098
Query: 535 IVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL-RTGQFDSQEY 593
V PP + + ++V + C+ A P LT+ + G+ LL + G S+
Sbjct: 2099 RVYVPPNIMGEEQNVSVLISQAVELLCQ-SDAIPPPTLTW-LKDGHPLLKKPGLSISENR 2156
Query: 594 TEYAVKSLSNENYGVYNCSIINEAG 618
+ ++ ++ G Y C N AG
Sbjct: 2157 SVLKIEDAQVQDTGRYTCEATNVAG 2181
Score = 73.6 bits (179), Expect = 8e-13
Identities = 89/354 (25%), Positives = 149/354 (42%), Gaps = 43/354 (12%)
Query: 274 SLTWVRSFGTLPEKTVLNGGT---LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRA 330
+L++VR+ TL L L I +T D G Y CIA ++ G ++ +
Sbjct: 460 TLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE- 518
Query: 331 LKKGRFWITPDPYHKDDNIQI--GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVI 388
P +N+ + G ++C + + + + +W +N R +R +E I
Sbjct: 519 --------PPPVIQVPNNVTVTPGERAVLTCLI--ISAVDYNLTWQRNDRDVRLAEPARI 568
Query: 389 TQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTV-P 447
+ +L++ +KF D G Y C+ S +GG S S+ + + PP +TV P
Sbjct: 569 R------TLANLSLELKSVKFNDAGEYHCMVSSEGGS-SAASVFLTVQE---PPKVTVMP 618
Query: 448 QEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQME-SYDGTLRIVNVS 506
+ +S G + + C TG PKP I W+ D + GS + + DGTL I N +
Sbjct: 619 KNQS---FTGGSEVSIMCSATGYPKPKIAWTVNDMFIV---GSHRYRMTSDGTLFIKNAA 672
Query: 507 REMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRA 566
+ +G+Y C S N + + ++ I V + L + G M C+
Sbjct: 673 PKDAGIYGCLAS--NSAGTDKQNSTLRYIEAPKLMVVQSELLVALGD--ITVMECKTSGI 728
Query: 567 YPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENY--GVYNCSIINEAG 618
P +V +W G+ LR F + +K ++ G Y C INEAG
Sbjct: 729 PPPQV---KWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG 779
Score = 72.0 bits (175), Expect = 2e-12
Identities = 122/519 (23%), Positives = 198/519 (38%), Gaps = 65/519 (12%)
Query: 121 IKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQ 180
+ S+ D P VT+ + K YY + + C +S P S+ R
Sbjct: 418 VSSVSFSSIVPDAPKVTMPE-----KTPGYYLQPGQIPCSVDSLLPFTLSFVRN------ 466
Query: 181 GSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTA 240
G GV+ Y + + L + + D Y CIA + F +S
Sbjct: 467 GVTLGVDQY---LKESASVNLDIAKVTLSDEGFYECIAV--SSAGTGRAQTFFDVSE--- 518
Query: 241 SPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRS-----FGTLPEKTVLNGGTL 295
P + V + + V PGE L C+ +LTW R+ L +L
Sbjct: 519 -PPPVIQVPNNVTVTPGERAVLTCLIISAVDY-NLTWQRNDRDVRLAEPARIRTLANLSL 576
Query: 296 TIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREV 355
+ ++ +DAG Y C+ ++ G+ A ++ + + + + P K+ + G EV
Sbjct: 577 ELKSVKFNDAGEYHCMVSSEGGSSA---ASVFLTVQEPPKVTVMP----KNQSFTGGSEV 629
Query: 356 KISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTY 415
I C P ++ +W N + S R +T S GT L I + D G Y
Sbjct: 630 SIMCSATGYPKPKI--AWTVNDMFIVGSHRYRMT------SDGT--LFIKNAAPKDAGIY 679
Query: 416 TCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPII 475
C+AS G S I + P L V Q S L+ GD ++C+ +G P P +
Sbjct: 680 GCLASNSAGTDKQNSTLRYIEA----PKLMVVQ--SELLVALGDITVMECKTSGIPPPQV 733
Query: 476 LWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLI 535
W + D E+ P + ++ G L+I +G Y C G + L
Sbjct: 734 KWFKGDLEL-RPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG----RATGKITLD 788
Query: 536 VQYPPAV--EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEY 593
V PP EPA + + G +VT+ C V + YP + + RL N + + F
Sbjct: 789 VGSPPVFIQEPADVSMEIGS--NVTLPCYV-QGYPEPTIKWR-RLDNMPIFSRPFSVSSI 844
Query: 594 TEYA-----VKSLSNENYGVYNCSIINEAGAGRCSFLVT 627
++ + +L + G Y C N+ G + VT
Sbjct: 845 SQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVT 883
Score = 57.8 bits (138), Expect = 5e-08
Identities = 91/400 (22%), Positives = 160/400 (40%), Gaps = 51/400 (12%)
Query: 44 RYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRF--QDSSVFNETLRITNIQ 101
R +E YT+ E L C+ G P P I W K ++ + + E L + N+
Sbjct: 4172 RSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGE-LILENVV 4230
Query: 102 RHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVA 161
G Y C A N G ++ + V+ L T + G+ + L C A
Sbjct: 4231 LEDSGFYTCVANNAAGEDT-HTVSLTVHVLP----TFTELPGDV--SLNKGEQLRLSCKA 4283
Query: 162 NSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIA--S 219
P + +W ++ D G ++++ ++ + +D Y C A S
Sbjct: 4284 TGIPLPKLTWTFNNNIIPAHFDS---------VNGHSELV-IERVSKEDSGTYVCTAENS 4333
Query: 220 VRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVR 279
V V I V K PS + +P+ G AI L C G+P P++ W R
Sbjct: 4334 VGFVKAIGFVYVKEPPVFKGDYPSNWI---EPL---GGNAI-LNC-EVKGDPTPTIQWNR 4385
Query: 280 SFGTLP---EKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRF 336
+ L G+L I ++DAG Y+C+A N G ++S ++ +++
Sbjct: 4386 KGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAG-VVERSMSLTLQSPP---- 4440
Query: 337 WITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVS 396
IT +P + I G ++ ++CQ P + T +W + G + +R+ + +
Sbjct: 4441 IITLEPV--ETVINAGGKIILNCQATGEP--QPTITWSRQGHSISWDDRVNVLSNN---- 4492
Query: 397 PGTTNLDIIDLKFTDFGTYTCVA-SLKGGGISDISIDVNI 435
+L I D + D + CVA +L G + + + V +
Sbjct: 4493 ----SLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQV 4528
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 125 bits (313), Expect = 2e-28
Identities = 156/586 (26%), Positives = 246/586 (41%), Gaps = 71/586 (12%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF-NETLRITNIQRHQGGRYYCKAE 113
G L LTC V+G P P + W K V L+++ +Q Q G Y C AE
Sbjct: 1948 GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAE 2007
Query: 114 NGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYE-RTVFLRCVANSNPPVRYSWR 172
N + A K V V V +S G A+E E + V L C A+ PP +W
Sbjct: 2008 N-TQAEARKDFVVAVL-----VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWL 2061
Query: 173 RGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVS 232
+ L G D G + F+ G + L LK LR D Y+C+A N +
Sbjct: 2062 KDGSPL--GQDMGPHL--RFYLDGGS--LVLKGLRASDAGAYTCVAH-----NPAGEDAR 2110
Query: 233 FRLSNKTASPSIKLLVD--DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP--EKT 288
N P+IK D +V PGE +T+VC G P ++W++ LP ++T
Sbjct: 2111 LHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPI-HVSWLKDGLPLPLSQRT 2169
Query: 289 VLNGG--TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKD 346
+L+G TL I + DAG ++C+A + G A ++ + V+ + P + D
Sbjct: 2170 LLHGSGHTLRISKVQLADAGIFTCVAASPAG-VADRNFTLQVQVPPV----LEPVEFQND 2224
Query: 347 DNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 406
+ G V++ C+ VP SW K+G PL S + P +L +
Sbjct: 2225 VVVVRGSLVELPCEARGVPLP--LVSWMKDGEPLLSQS----LEQGP-------SLQLEA 2271
Query: 407 LKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQ 466
+ D GTY+CVA + G + + + PP++ + + L G +EL C
Sbjct: 2272 VGAGDSGTYSCVA-VSEAGEARRHFQLTVME---PPHIEDSGQPTELSLTPGAPMELLCD 2327
Query: 467 VTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVK 526
G P+P I W + + + ++E+ R++ V +G+Y C G
Sbjct: 2328 AQGTPQPNITWHKDGQALT------RLENNSRATRVLRV--RDAGLYTCLAESPAG---- 2375
Query: 527 PREALVQLIVQYPPAV----EPAF-LEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNK 581
E ++ VQ PP + P F + + GQ + + C V A P +T+ R G
Sbjct: 2376 AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQ---LVLECSV-EAEPAPKITWH-RDGIV 2430
Query: 582 LLRTGQFDSQEYTEY-AVKSLSNENYGVYNCSIINEAGAGRCSFLV 626
L E + +++LS + G Y+C+ N AG+ +F V
Sbjct: 2431 LQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRV 2476
Score = 118 bits (296), Expect = 2e-26
Identities = 144/592 (24%), Positives = 235/592 (39%), Gaps = 67/592 (11%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDS-SVFNETLRITNIQRHQGGRYYC 110
+ E ++ L CL +G P P + W K S + SV LRI Q G Y C
Sbjct: 706 VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRC 765
Query: 111 KAENGLGSPAIK-SIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRY 169
A N GS ++ +RV+V P +T+ S+ V L C A P
Sbjct: 766 VASNVAGSTELRYGLRVNV----PPRITLPPSL---PGPVLVNTPVRLTCNATGAPSPTL 818
Query: 170 SWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDK 229
W + + G++++ ++L L + R D YSC+A + D
Sbjct: 819 MWLKDGNPVSPAGTPGLQVFP------GGRVLTLASARASDSGRYSCVAVSAVGEDRQDV 872
Query: 230 MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV 289
++ + PSI L + + V E++ L C + P P L+W + L +
Sbjct: 873 VLQVHM-----PPSI-LGEELNVSVVANESVALEC-QSHAMPPPVLSWWKDGRPLEPRPG 925
Query: 290 L----NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITP-DPYH 344
+ + L + DAG Y+C A N G ++K N+ V W+ P P
Sbjct: 926 VHLSADKALLQVDRADVWDAGHYTCEALNQAGR-SEKHYNLNV--------WVAPVFPLR 976
Query: 345 KDDNIQI--GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNL 402
+ + + G +SC+ VP ++ SW K+G+PL + VS L
Sbjct: 977 ESHTLTVREGHPTSLSCECRGVPFPKI--SWRKDGQPLPGEGAGL-----QHVSAVGRLL 1029
Query: 403 DIIDLKFTDFGTYTCVAS-LKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTI 461
+ + GTYTC S + G D+ ++V+ VPP + P+E V+ D +
Sbjct: 1030 YLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVH-----VPPQIAGPREPPTQVSVVQDGV 1084
Query: 462 -ELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQY 520
L+C TGKP P + W R + V G +Q+++ +L + +G Y C
Sbjct: 1085 ATLECNATGKPPPTVTWERDGQPVGAELG-LQLQNQGQSLHVERAQAAHTGRYSCVAENL 1143
Query: 521 NGFNVKPREALVQLIVQYPPA----VEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEW 576
G E +L V PP ++P I +T+ C + P + W
Sbjct: 1144 AG----RAERKFELSVLVPPELIGDLDP-LTNITAALHSPLTLLCEAMGIPPPAI---RW 1195
Query: 577 RLGNKLLRTGQFDSQEYTEYAVK--SLSNENYGVYNCSIINEAGAGRCSFLV 626
G + + G+ + +K ++ G+Y+C NEAG R +F V
Sbjct: 1196 FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSV 1247
Score = 117 bits (292), Expect = 7e-26
Identities = 151/622 (24%), Positives = 253/622 (40%), Gaps = 83/622 (13%)
Query: 43 ERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNET--LRITNI 100
E ++ T+ + L C P P I W K G+ + ++ + T L+I N
Sbjct: 1353 EDSADEEVTVTVNNPISLICEALAFPSPNITWMKD-GAPFEASRNIQLLPGTHGLQILNA 1411
Query: 101 QRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEA---KEQFYYERTVFL 157
Q+ G+Y C N LG A+K+ V+V L P ++ +GE + + T+ L
Sbjct: 1412 QKEDAGQYTCVVTNELGE-AVKNYHVEV--LIPPSISKDDPLGEVGVKEVKTKVNSTLTL 1468
Query: 158 RCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCI 217
C + + PP W + + + S V GE ++L+++ + D Y C+
Sbjct: 1469 ECESWAVPPPTIRWYKDGQPVTPSSRLQV--------LGEGRLLQIQPTQVSDSGRYLCV 1520
Query: 218 ASVRNVC------------------NIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEA 259
A+ NV + D +F + ++ + IV N
Sbjct: 1521 AT--NVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVEN--NP 1576
Query: 260 ITLVCVTTGGEPAPSLTWVRSFGTL---PEKTVLNGG-TLTIPAITSDDAGTYSCIANNN 315
L C T P P LTW R L E +VL GG L IP + +++AG YSC A+N
Sbjct: 1577 AYLYC-DTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNE 1635
Query: 316 VGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFK 375
VG +++ I D + + + +S Q A+ + T SW +
Sbjct: 1636 VGEDWLHYELLVLTPPV-----ILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQ 1690
Query: 376 NGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDI-SIDVN 434
NG P S R+ + + D V L + + D +Y CVA + G + ++ V
Sbjct: 1691 NGLPFSPSPRLQVLE-DGQV------LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ 1743
Query: 435 ISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQME 494
VPP + + + ++ L C V P P + W + + +++ + +
Sbjct: 1744 -----VPPRI-AGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLP 1797
Query: 495 SYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPA------FLE 548
TL++ SGMY C+ G + K LVQL V PPA A +
Sbjct: 1798 G-THTLQLGRARLSDSGMYTCEALNAAGRDQK----LVQLSVLVPPAFRQAPRGPQDAVL 1852
Query: 549 IRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL---RTGQFDSQEYTEYAVKSLSNEN 605
+R G D++V +SC A P +T+ ++ G L+ RT + E +S++
Sbjct: 1853 VRVG-DKAV-LSCET-DALPEPTVTW-YKDGQPLVLAQRTQALRGGQRLEIQEAQVSDK- 1907
Query: 606 YGVYNCSIINEAGAGRCSFLVT 627
G+Y+C + N AG +F +T
Sbjct: 1908 -GLYSCKVSNVAGEAVRTFTLT 1928
Score = 116 bits (291), Expect = 9e-26
Identities = 145/596 (24%), Positives = 238/596 (39%), Gaps = 86/596 (14%)
Query: 50 YTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF-NETLRITNIQRHQGGRY 108
+T+ + LTC TG P P + W+K R V + L I GRY
Sbjct: 2675 FTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRY 2734
Query: 109 YCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
C A N G + V + PVV S+ A E V L C A+ P
Sbjct: 2735 TCSARNSAG---VAHKHVFLTVQASPVVKPLPSVVRA----VAEEEVLLPCEASGIPRPT 2787
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
+W++ +G + + G+ L++ + P+D NY CIA
Sbjct: 2788 ITWQK------EGLNVATGVSTQVLPGGQ---LRIAHASPEDAGNYLCIA---------- 2828
Query: 229 KMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTG----------GEPAPSLTWV 278
+ S +A +L+V P V+ G + + T G G P P++TW
Sbjct: 2829 -----KNSAGSAMGKTRLVVQVPPVIENG--LPDLSTTEGSHAFLPCKARGSPEPNITWD 2881
Query: 279 RS----FGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKG 334
+ G + T+ G L + + DAGTY+C A N VG A++ ++ + L
Sbjct: 2882 KDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR-ARRRVHLTILVLPV- 2939
Query: 335 RFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPD 394
F P D ++++G + + C P+ + W N RP+ +++ D
Sbjct: 2940 -FTTLPG----DRSLRLGDRLWLRCAARGSPTPRI--GWTVNDRPVTEG----VSEQD-- 2986
Query: 395 VSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLV 454
G + L + D GTY C A + G +S V++ + V + S LV
Sbjct: 2987 ---GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF-VHVKEAPVLQG----EAFSYLV 3038
Query: 455 TREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYR 514
G +I+L C V G P P I W + + + ++ + +G+L I R+ +G Y+
Sbjct: 3039 EPVGGSIQLDCVVRGDPVPDIHWIK--DGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQ 3096
Query: 515 CQTSQYNGFNVKPREALVQLIVQYPPA--VEPAFLEIRQGQDRSVTMSCRVLRAYPIRVL 572
C G K +V L++Q P VEP + +R G D V + C +A
Sbjct: 3097 CLAENEMGVAKK----VVILVLQSAPVFQVEPQDMTVRSGDD--VALRC---QATGEPTP 3147
Query: 573 TYEW-RLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRC-SFLV 626
T EW + G L + + + ++++ + G Y+C N G+ +FLV
Sbjct: 3148 TIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLV 3203
Score = 111 bits (277), Expect = 4e-24
Identities = 132/550 (24%), Positives = 221/550 (40%), Gaps = 72/550 (13%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSASDR---FQDSSVFNETLRITNIQRHQGGR 107
T+REG L+C G P P+I W K Q S L + Q Q G
Sbjct: 982 TVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 1041
Query: 108 YYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPV 167
Y C+ N +G+ + + ++++V+ P + + L C A PP
Sbjct: 1042 YTCECSNVVGNSS-QDLQLEVHV---PPQIAGPREPPTQVSVVQDGVATLECNATGKPPP 1097
Query: 168 RYSWRR-GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNI 226
+W R GQ V G++ G+++ Q + + L ++ + YSC+A N+
Sbjct: 1098 TVTWERDGQPV---GAELGLQL------QNQGQSLHVERAQAAHTGRYSCVA--ENLAGR 1146
Query: 227 PDKMVSFRLSNKTASPSIKLLVDDP---IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGT 283
++ F LS I L DP I +TL+C G P P++ W R G
Sbjct: 1147 AER--KFELSVLVPPELIGDL--DPLTNITAALHSPLTLLCEAM-GIPPPAIRWFR--GE 1199
Query: 284 LP----EKTVL--NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFW 337
P E T L G L + D+G YSC+A+N G A+++ ++ V
Sbjct: 1200 EPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGE-ARRNFSVEV--------- 1249
Query: 338 ITPDPYHKDDNIQI-----GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTD 392
+ P +D ++ G+ + C V P +LT WFK+GRPL +
Sbjct: 1250 LVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLT--WFKDGRPLARGDA------- 1300
Query: 393 PDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKS- 451
+SP L ++ + G Y+C+A+ + + + +S P L ++ +
Sbjct: 1301 HHISPDGVLLQVLQANLSSAGHYSCIAA---NAVGEKTKHFQLSVLLAPTILGGAEDSAD 1357
Query: 452 -PLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT--LRIVNVSRE 508
+ + I L C+ P P I W K+ A + S ++ GT L+I+N +E
Sbjct: 1358 EEVTVTVNNPISLICEALAFPSPNITWM---KDGAPFEASRNIQLLPGTHGLQILNAQKE 1414
Query: 509 MSGMYRCQTSQYNGFNVKPREALVQL---IVQYPPAVEPAFLEIRQGQDRSVTMSCRVLR 565
+G Y C + G VK V + I + P E E++ + ++T+ C
Sbjct: 1415 DAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWA 1474
Query: 566 AYPIRVLTYE 575
P + Y+
Sbjct: 1475 VPPPTIRWYK 1484
Score = 111 bits (277), Expect = 4e-24
Identities = 146/599 (24%), Positives = 234/599 (39%), Gaps = 84/599 (14%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF--NETLRITNIQRHQGGRYY 109
+R G+ L+C P P + W K G Q + + L I Q G Y
Sbjct: 1853 VRVGDKAVLSCETDALPEPTVTWYKD-GQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYS 1911
Query: 110 CKAENGLGSPA---IKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPP 166
CK N G +++V + + TV Q G + L C + P
Sbjct: 1912 CKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGS---------PLVLTCDVSGVPA 1962
Query: 167 VRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNI 226
+W + + + + GV ++G L+L L+P Y+C+A
Sbjct: 1963 PTVTWLKDRMPVESSAVHGV------VSRGGR--LQLSRLQPAQAGTYTCVAENTQAEAR 2014
Query: 227 PDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPE 286
D +V+ ++ + S V V G+ + L C G+P P + W++ L +
Sbjct: 2015 KDFVVAVLVAPRIRSSG----VAREHHVLEGQEVRLDC-EADGQPPPDVAWLKDGSPLGQ 2069
Query: 287 ------KTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKST-NIIVRALKK----GR 335
+ L+GG+L + + + DAG Y+C+A+N G A+ T N++V K G
Sbjct: 2070 DMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGS 2129
Query: 336 FWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDV 395
+ P G V + C V P + SW K+G PL S+R ++
Sbjct: 2130 GTLVSRP---------GELVTMVCPVRGSP--PIHVSWLKDGLPLPLSQRTLLH------ 2172
Query: 396 SPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVT 455
G T L I ++ D G +TCVA+ G++D + + + VPP L + ++ +V
Sbjct: 2173 GSGHT-LRISKVQLADAGIFTCVAA-SPAGVADRNFTLQVQ---VPPVLEPVEFQNDVVV 2227
Query: 456 REGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRC 515
G +EL C+ G P P++ W + D E + Q S L++ V SG Y C
Sbjct: 2228 VRGSLVELPCEARGVPLPLVSWMK-DGEPLLSQSLEQGPS----LQLEAVGAGDSGTYSC 2282
Query: 516 QTSQYNGFNVKPREALVQLIVQYPPAVE----PAFLEIRQGQDRSVTMSCRVLRAYPIRV 571
G QL V PP +E P L + G + + P
Sbjct: 2283 VAVSEAG----EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDA---QGTPQPN 2335
Query: 572 LTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKA 630
+T+ + G L R E A + L + G+Y C + AGA SF V +A
Sbjct: 2336 ITWH-KDGQALTRL------ENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQA 2387
Score = 110 bits (276), Expect = 5e-24
Identities = 135/592 (22%), Positives = 244/592 (41%), Gaps = 77/592 (13%)
Query: 57 TLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF----NETLRITNIQRHQGGRYYCKA 112
++ L C V HP P++ W K + + S VF TL++ + G Y C+A
Sbjct: 1763 SVSLPCDVHAHPNPEVTWYKDSQALS---LGEEVFLLPGTHTLQLGRARLSDSGMYTCEA 1819
Query: 113 ENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERT---VFLRCVANSNPPVRY 169
N G K +++ V V + + R L C ++ P
Sbjct: 1820 LNAAGRDQ-KLVQLSVL-----VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTV 1873
Query: 170 SWRR-GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
+W + GQ ++L + + +G + L+++ + D YSC V N+
Sbjct: 1874 TWYKDGQPLVLAQRTQAL--------RGGQR-LEIQEAQVSDKGLYSC-----KVSNVAG 1919
Query: 229 KMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT 288
+ V P+ + + + G + L C G PAP++TW++ +
Sbjct: 1920 EAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTC-DVSGVPAPTVTWLKDRMPVESSA 1978
Query: 289 V----LNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH 344
V GG L + + AGTY+C+A N A+ + +V L R I
Sbjct: 1979 VHGVVSRGGRLQLSRLQPAQAGTYTCVAEN---TQAEARKDFVVAVLVAPR--IRSSGVA 2033
Query: 345 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTT---- 400
++ ++ G+EV++ C+ + P ++ +W K+G PL D+ P
Sbjct: 2034 REHHVLEGQEVRLDCEADGQPPPDV--AWLKDGSPL-----------GQDMGPHLRFYLD 2080
Query: 401 --NLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKS-PLVTRE 457
+L + L+ +D G YTCVA G + + VN+ VPP + + S LV+R
Sbjct: 2081 GGSLVLKGLRASDAGAYTCVAHNPAGEDARLH-TVNV---LVPPTIKQGADGSGTLVSRP 2136
Query: 458 GDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQT 517
G+ + + C V G P + W + + + ++ + TLRI V +G++ C
Sbjct: 2137 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTL-LHGSGHTLRISKVQLADAGIFTCVA 2195
Query: 518 SQYNGFNVKPREALVQLIVQYPPAVEPAFL--EIRQGQDRSVTMSCRVLRAYPIRVLTYE 575
+ G V R +Q VQ PP +EP ++ + V + C R P+ ++++
Sbjct: 2196 ASPAG--VADRNFTLQ--VQVPPVLEPVEFQNDVVVVRGSLVELPCEA-RGVPLPLVSW- 2249
Query: 576 WRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 627
+ G LL ++ ++++ + G Y+C ++EAG R F +T
Sbjct: 2250 MKDGEPLLSQ---SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 2298
Score = 108 bits (270), Expect = 2e-23
Identities = 134/598 (22%), Positives = 230/598 (38%), Gaps = 93/598 (15%)
Query: 48 RVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF---NETLRITNIQRHQ 104
R + + EG+ + L C G P P + W K F +L + ++
Sbjct: 2034 REHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASD 2093
Query: 105 GGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSN 164
G Y C A N PA + R+ + P + G V + C +
Sbjct: 2094 AGAYTCVAHN----PAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGS 2149
Query: 165 PPVRYSWRR-------GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCI 217
PP+ SW + Q LL GS G T L++ ++ D ++C+
Sbjct: 2150 PPIHVSWLKDGLPLPLSQRTLLHGS-------------GHT--LRISKVQLADAGIFTCV 2194
Query: 218 ASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTW 277
A+ + + D+ + ++ ++ D +VV G + L C G P P ++W
Sbjct: 2195 AA--SPAGVADRNFTLQVQVPPVLEPVEFQND--VVVVRGSLVELPCEARG-VPLPLVSW 2249
Query: 278 VRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFW 337
++ L +++ G +L + A+ + D+GTYSC+A + G A++ + V
Sbjct: 2250 MKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGE-ARRHFQLTVM-------- 2300
Query: 338 ITPDPYHKDD-------NIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQ 390
+P H +D ++ G +++ C + P +T W K+G+ L E
Sbjct: 2301 ---EPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT--WHKDGQALTRLEN----- 2350
Query: 391 TDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEK 450
+ T + L+ D G YTC+A G I + S V + + PPN+ P+
Sbjct: 2351 -----NSRATRV----LRVRDAGLYTCLAESPAGAI-EKSFRVRVQA---PPNIVGPRGP 2397
Query: 451 SPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMS 510
+V + L+C V +P P I W R D V D Q L++ +S S
Sbjct: 2398 RFVVGLAPGQLVLECSVEAEPAPKITWHR-DGIVLQEDAHTQFPERGRFLQLQALSTADS 2456
Query: 511 GMYRCQTSQYNG-----FNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLR 565
G Y C G F V+ V I PPAV + +++ + C +
Sbjct: 2457 GDYSCTARNAAGSTSVAFRVEIH--TVPTIRSGPPAVNVSV-------NQTALLPC---Q 2504
Query: 566 AYPIRVLTYEWRLGNKLL--RTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGR 621
A + WR L R+ +F+ ++ + ++ G Y C N AG+ R
Sbjct: 2505 ADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR 2562
Score = 107 bits (268), Expect = 4e-23
Identities = 127/478 (26%), Positives = 186/478 (38%), Gaps = 67/478 (14%)
Query: 49 VYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRY 108
V + E E L L C +G PRP I W K + + + LRI + G Y
Sbjct: 2766 VRAVAEEEVL-LPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY 2824
Query: 109 YCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
C A+N GS A+ R+ V PV+ E + FL C A +P
Sbjct: 2825 LCIAKNSAGS-AMGKTRLVVQV--PPVIENGLPDLSTTEGSH----AFLPCKARGSPEPN 2877
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
+W + + + K FT + L +KNL QD Y+C A N
Sbjct: 2878 ITWDKDGQPVSGAEGK--------FTIQPSGELLVKNLEGQDAGTYTCTAE--NAVGRAR 2927
Query: 229 KMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT 288
+ V + P L D + G+ + L C G P P + W + + E
Sbjct: 2928 RRVHLTI---LVLPVFTTLPGDRSL-RLGDRLWLRCAARGS-PTPRIGWTVNDRPVTEGV 2982
Query: 289 VLN--GGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRA--LKKGRFWITPDPYH 344
G TL A++ +D+GTY C A N VG S + A L+ F +P
Sbjct: 2983 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP-- 3040
Query: 345 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDI 404
+G +++ C V P ++ W K+G PLR S Q +L I
Sbjct: 3041 ------VGGSIQLDCVVRGDPVPDI--HWIKDGLPLRGSHLRHQLQNG--------SLTI 3084
Query: 405 IDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQ 464
+ D G Y C+A + G + I V S+ P PQ+ + R GD + L+
Sbjct: 3085 HRTERDDAGRYQCLAENEMGVAKKVVILVLQSA---PVFQVEPQD---MTVRSGDDVALR 3138
Query: 465 CQVTGKPKPIILWSRADKEV-------AMPDGSMQMESYDGTLRIVNVSREMSGMYRC 515
CQ TG+P P I W +A + + +PDGS+ +E NV +G Y C
Sbjct: 3139 CQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLE---------NVETGDAGTYDC 3187
Score = 100 bits (249), Expect = 6e-21
Identities = 144/581 (24%), Positives = 214/581 (36%), Gaps = 120/581 (20%)
Query: 23 VYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTA---- 78
VY PP++R G N+ G++L L C G P P+I W K A
Sbjct: 91 VYVPPSIR--EDGRKANVSG----------MAGQSLTLECDANGFPVPEIVWLKDAQLVG 138
Query: 79 ------GSASD---------RFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKS 123
G D R D ++L IQ + GR +A + A
Sbjct: 139 VPLGWAGYGWDLGWGQVGGHRLLDEG---QSLHFPRIQPGRSGRRGAQAGGSAQTKAPWX 195
Query: 124 IRV-------DVYYLDDPVVTVHQSIGEAKEQFYYERT-VFLRCVANSNPPVRYSWRRGQ 175
+ + P G A+E V L+C + P + W + +
Sbjct: 196 AGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDR 255
Query: 176 EVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRL 235
+ +L G Q + ++L++ D Y C+A D +
Sbjct: 256 QPVLPGGPH-------LQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHA 308
Query: 236 ------SNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV 289
SN+T + V + L+C G P P++TW + LP T
Sbjct: 309 PPTIWGSNETGE----------VAVMEDHLVQLLCEARG-VPTPNITWFKDGALLPTSTK 357
Query: 290 L----NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKK-----GRFWITP 340
+ G L + S DAG Y+C A+N VG A+K+T + V GR ++
Sbjct: 358 VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG-AAEKATRLDVYVPPTIEGAGGRPYVV- 415
Query: 341 DPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDV----S 396
GR V + C PS T SW G P+ S + +TD V S
Sbjct: 416 -------KAVAGRPVALECVARGHPSP--TLSWHHEGLPVAESNESRL-ETDGSVLRLES 465
Query: 397 PGTTNLDIIDLKFTDFGTYTCVASLKGG-GISDISIDVNISSSTVPPNLTVPQEKSPLVT 455
PG + G Y+CVAS G + S++V VPP L V + + T
Sbjct: 466 PGEASS----------GLYSCVASSPAGEAVLQYSVEVQ-----VPPQLLVAEGLGQVTT 510
Query: 456 REGDTIELQCQVTGKPKPIILW---SRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGM 512
G +EL CQ +G P P I W R +E+A +Q+ S TL I +V + SG+
Sbjct: 511 IVGQPLELPCQASGSPVPTIQWLQNGRPAEELA----GVQVASQGTTLHIDHVELDHSGL 566
Query: 513 YRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQ 553
+ CQ + N E V + ++ P V LE+ GQ
Sbjct: 567 FACQAT--NEAGTAGAEVEVSVHGEWAPGV----LEVPIGQ 601
Score = 99.8 bits (247), Expect = 1e-20
Identities = 139/579 (24%), Positives = 219/579 (37%), Gaps = 74/579 (12%)
Query: 58 LELTCLVTGHPRPQIRWTKTA----GSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAE 113
L L C V P P+I W + A +F + F L++ + G Y C A
Sbjct: 2408 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF---LQLQALSTADSGDYSCTAR 2464
Query: 114 NGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRR 173
N GS ++ + RV+++ V T+ G +T L C A+ P SWR+
Sbjct: 2465 NAAGSTSV-AFRVEIH----TVPTIRS--GPPAVNVSVNQTALLPCQADGVPAPLVSWRK 2517
Query: 174 GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSF 233
+ L S P F L+++ + QD +Y C+AS N +
Sbjct: 2518 DRVPLDPRS--------PRFEILPEGSLRIQPVLAQDAGHYLCLAS--NSAGSDRQGRDL 2567
Query: 234 RLSNKTA---SPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT-- 288
R+ A SPS L + P EA G P P + W + L +
Sbjct: 2568 RVLEPPAIAPSPSNLTLTAHTPALLPCEA--------SGSPKPLVVWWKDGQKLDFRLQQ 2619
Query: 289 ----VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH 344
+L L + A D+ + C+ +N VG A + + V I D
Sbjct: 2620 GAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGE-AHRLYQVTVHVPPT----IADD--Q 2672
Query: 345 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDI 404
D + + V ++C +P+ T SW K G L + + VSP L+I
Sbjct: 2673 TDFTVTMMAPVVLTCHSTGIPAP--TVSWSKAGAQLGARG------SGYRVSPSGA-LEI 2723
Query: 405 IDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTRE--GDTIE 462
G YTC A G++ + + + +S V L P V R + +
Sbjct: 2724 GQALPIHAGRYTCSAR-NSAGVAHKHVFLTVQASPVVKPL-------PSVVRAVAEEEVL 2775
Query: 463 LQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNG 522
L C+ +G P+P I W + VA + + G LRI + S E +G Y C G
Sbjct: 2776 LPCEASGIPRPTITWQKEGLNVATGVSTQVLPG--GQLRIAHASPEDAGNYLCIAKNSAG 2833
Query: 523 FNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKL 582
+ +L+VQ PP +E ++ + + C+ R P +T++
Sbjct: 2834 SAM----GKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA-RGSPEPNITWDKDGQPVS 2888
Query: 583 LRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGR 621
G+F Q E VK+L ++ G Y C+ N G R
Sbjct: 2889 GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRAR 2927
Score = 96.7 bits (239), Expect = 9e-20
Identities = 119/523 (22%), Positives = 218/523 (41%), Gaps = 54/523 (10%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNE--TLRITNIQRHQGGRYYCKA 112
G+ LEL C +G P P I+W + G ++ V ++ TL I +++ G + C+A
Sbjct: 513 GQPLELPCQASGSPVPTIQWLQN-GRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA 571
Query: 113 ENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSW- 171
N G+ A + V V+ P V + IG Q+++ A +PPV W
Sbjct: 572 TNEAGT-AGAEVEVSVHGEWAPGV-LEVPIG----QYHWGXEHHSSFPAACDPPVHRGWG 625
Query: 172 RRGQEVLLQG-SDKGVEIYEPFFTQGETKI---LKLKNLRPQDYANYSCIASVRNVCNIP 227
+ L++G G EP + L+++ + +D Y+C A+ N+
Sbjct: 626 AHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT--NLAGES 683
Query: 228 DKMVSFRL---SNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL 284
+ V+ ++ N P K ++++ ++TL C+ + G P P ++W + +
Sbjct: 684 KREVALKVLVPPNIEPGPVNKAVLEN-------ASVTLECLAS-GVPPPDVSWFKGHQPV 735
Query: 285 PE----KTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITP 340
++G L I DAG+Y C+A+N G+ + +R R + P
Sbjct: 736 SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG---LRVNVPPRITLPP 792
Query: 341 DPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTT 400
+ + V+++C PS T W K+G P+ + + V PG
Sbjct: 793 S---LPGPVLVNTPVRLTCNATGAPSP--TLMWLKDGNPVSPAGTPGL-----QVFPGGR 842
Query: 401 NLDIIDLKFTDFGTYTCVA-SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGD 459
L + + +D G Y+CVA S G D+ + V+ +PP++ + +V E
Sbjct: 843 VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVH-----MPPSILGEELNVSVVANE-- 895
Query: 460 TIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQ 519
++ L+CQ P P++ W + D P + + + L++ +G Y C+
Sbjct: 896 SVALECQSHAMPPPVLSWWK-DGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALN 954
Query: 520 YNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCR 562
G + K V + + P E L +R+G S++ CR
Sbjct: 955 QAGRSEKHYNLNVWVAPVF-PLRESHTLTVREGHPTSLSCECR 996
Score = 92.8 bits (229), Expect = 1e-18
Identities = 135/605 (22%), Positives = 229/605 (37%), Gaps = 74/605 (12%)
Query: 47 ERVYTIREGETLELTCLVTGHPRPQIRWTKTAGS-ASDRFQDSSVFNETLRITNIQRHQG 105
E V + +G+T L C VTGHP+P++ W K A S L++
Sbjct: 1261 EEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSA 1320
Query: 106 GRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNP 165
G Y C A N +G K ++ V L ++ + + + + L C A + P
Sbjct: 1321 GHYSCIAANAVGEKT-KHFQLSV-LLAPTILGGAEDSADEEVTVTVNNPISLICEALAFP 1378
Query: 166 PVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCN 225
+W + + + +++ T L++ N + +D Y+C+ V N
Sbjct: 1379 SPNITWMKDGAPF--EASRNIQLLP------GTHGLQILNAQKEDAGQYTCV-----VTN 1425
Query: 226 IPDKMVSFRLSNKTASPSIKLLVDDP--------IVVNPGEAITLVCVTTGGEPAPSLTW 277
+ V PSI DDP + +TL C + P P++ W
Sbjct: 1426 ELGEAVKNYHVEVLIPPSIS--KDDPLGEVGVKEVKTKVNSTLTLEC-ESWAVPPPTIRW 1482
Query: 278 VRSFGTLPEKTVL----NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRA--- 330
+ + + L G L I D+G Y C+A N G + N++++
Sbjct: 1483 YKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGED-DQDFNVLIQVPPM 1541
Query: 331 -LKKGRFWITPDPYHKDDNIQIG----REV------KISCQVEAVPSEELTFSWFKNGRP 379
K G F + +++ + G RE+ + C A+P +LT W++ +P
Sbjct: 1542 FQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLT--WYREDQP 1599
Query: 380 LRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSST 439
L + + + + Q G L I ++ + G Y+C AS + + + + T
Sbjct: 1600 LSAGDEVSVLQ-------GGRVLQIPLVRAENAGRYSCKAS---NEVGEDWLHYELLVLT 1649
Query: 440 VPPNLTVPQEKSPLVT-REGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDG 498
P L +E VT T+ LQC G P P I W + + P +Q+
Sbjct: 1650 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS-PSPRLQVLEDGQ 1708
Query: 499 TLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLE-IRQGQDRSV 557
L++ + Y C G E L L VQ PP + LE + + SV
Sbjct: 1709 VLQVSTAEVADAASYMCVAENQAG----SAEKLFTLRVQVPPRIAGLDLEQVTAILNSSV 1764
Query: 558 TMSCRVLRAYPIRVLTYEWRLGNKLLRTGQ----FDSQEYTEYAVKSLSNENYGVYNCSI 613
++ C V A+P +T W ++ L G+ + LS+ G+Y C
Sbjct: 1765 SLPCDV-HAHPNPEVT--WYKDSQALSLGEEVFLLPGTHTLQLGRARLSDS--GMYTCEA 1819
Query: 614 INEAG 618
+N AG
Sbjct: 1820 LNAAG 1824
Score = 82.4 bits (202), Expect = 2e-15
Identities = 132/580 (22%), Positives = 218/580 (37%), Gaps = 63/580 (10%)
Query: 56 ETLELTCLVTGHPRPQIRWTKTAGSASDR-FQDSSVFNETLRITNIQRHQGGRYYCKAEN 114
E++ L C P P + W K R S L++ G Y C+A N
Sbjct: 895 ESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALN 954
Query: 115 GLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRG 174
G K ++V+ PV + +S + + L C P + SWR+
Sbjct: 955 QAGRSE-KHYNLNVWVA--PVFPLRESHTLTVREGH---PTSLSCECRGVPFPKISWRKD 1008
Query: 175 QEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFR 234
+ L G G++ ++L L + Y+C S + D +
Sbjct: 1009 GQPL-PGEGAGLQ-----HVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVH 1062
Query: 235 LSNKTASPSIKLLVDDPI---VVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN 291
+ + A P + P VV G A TL C TG +P P++TW R + + L
Sbjct: 1063 VPPQIAGPR-----EPPTQVSVVQDGVA-TLECNATG-KPPPTVTWERDGQPVGAELGLQ 1115
Query: 292 ----GGTLTIPAITSDDAGTYSCIANNNVGNPAKK-STNIIVRALKKGRFWITPDPYHKD 346
G +L + + G YSC+A N G +K +++V G DP
Sbjct: 1116 LQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDL----DPL--- 1168
Query: 347 DNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 406
NI ++ EA+ WF+ P+ E D + G L +
Sbjct: 1169 TNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGE-------DTYLLAGGWMLKMTQ 1221
Query: 407 LKFTDFGTYTCVASLKGGGIS-DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQC 465
+ D G Y+C+AS + G + S++V VPP++ + + +G T L C
Sbjct: 1222 TQEQDSGLYSCLASNEAGEARRNFSVEV-----LVPPSIENEDLEEVIKVLDGQTAHLMC 1276
Query: 466 QVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT-LRIVNVSREMSGMYRCQTSQYNGFN 524
VTG P+P + W + + +A G S DG L+++ + +G Y C + G
Sbjct: 1277 NVTGHPQPKLTWFKDGRPLAR--GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEK 1334
Query: 525 VKPREALVQLIVQYPPAV-----EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLG 579
K QL V P + + A E+ + +++ C L A+P +T+ + G
Sbjct: 1335 TKH----FQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEAL-AFPSPNITW-MKDG 1388
Query: 580 NKLLRTGQFDSQEYTE-YAVKSLSNENYGVYNCSIINEAG 618
+ T + + E+ G Y C + NE G
Sbjct: 1389 APFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1428
Score = 79.7 bits (195), Expect = 1e-14
Identities = 133/598 (22%), Positives = 226/598 (37%), Gaps = 86/598 (14%)
Query: 62 CLVTGHPRPQIRWTKTAGSASDRFQDSSVFNE--TLRITNIQRHQGGRYYCKAENGLGSP 119
C G P+PQ+ W K S Q E +L + ++ G Y C+A N +GS
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83
Query: 120 AIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVL- 178
+ + ++ VY ++ + +A +++ L C AN P W + +++
Sbjct: 84 S-RRAKLVVYV----PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVG 138
Query: 179 ------LQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIP----- 227
G D G E + L ++P A P
Sbjct: 139 VPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGL 198
Query: 228 ---DKMVSFRLSNKTASPSI-KLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGT 283
++ + + A PS+ ++ G + L C T G P P + W T
Sbjct: 199 AGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQC-WTSGVPTPQVEW-----T 252
Query: 284 LPEKTVLNGG----------TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKK 333
+ VL GG L I D G Y C+A + G A+ + +R
Sbjct: 253 KDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQAR---DFQLRVHAP 309
Query: 334 GRFW---ITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQ 390
W T + +D++ V++ C+ VP+ +T WFK+G L +S ++V T+
Sbjct: 310 PTIWGSNETGEVAVMEDHL-----VQLLCEARGVPTPNIT--WFKDGALLPTSTKVVYTR 362
Query: 391 TDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDIS-IDVNISSSTVPPNLTVPQE 449
G L + + +D G YTC AS G + +DV VPP +
Sbjct: 363 -------GGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-----YVPPTIEGAGG 410
Query: 450 KSPLVTR--EGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSR 507
+ P V + G + L+C G P P + W VA + S ++E+ LR+ +
Sbjct: 411 R-PYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNES-RLETDGSVLRLESPGE 468
Query: 508 EMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVE-PAFLEIRQGQDRSVTMSCRVL-- 564
SG+Y C S G + ++QY V+ P L + +G + T+ + L
Sbjct: 469 ASSGLYSCVASSPAG----------EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLEL 518
Query: 565 --RAYPIRVLTYEWRLGNKLLR--TGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAG 618
+A V T +W + G + + T + + ++ G++ C NEAG
Sbjct: 519 PCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 576
Score = 74.3 bits (181), Expect = 5e-13
Identities = 74/289 (25%), Positives = 124/289 (42%), Gaps = 31/289 (10%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYC 110
++R G+ L L C G P P+I WT ++ + TL+ + R G Y C
Sbjct: 2948 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDG-GSTLQRAAVSREDSGTYVC 3006
Query: 111 KAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYE--RTVFLRCVANSNPPVR 168
AEN +G S V+ + PV+ GEA ++ L CV +P
Sbjct: 3007 WAENRVGRTQAVSF---VHVKEAPVLQ-----GEAFSYLVEPVGGSIQLDCVVRGDPVPD 3058
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
W + + L+GS ++ T T+ D Y C+A N +
Sbjct: 3059 IHWIK-DGLPLRGSHLRHQLQNGSLTIHRTE--------RDDAGRYQCLAE--NEMGVAK 3107
Query: 229 KMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT 288
K+V L + +P ++ D + V G+ + L C TG EP P++ W+++ L
Sbjct: 3108 KVVILVLQS---APVFQVEPQD-MTVRSGDDVALRCQATG-EPTPTIEWLQAGQPLRASR 3162
Query: 289 ---VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKG 334
L G+L + + + DAGTY C+A+N +G+ ++ ++VR +G
Sbjct: 3163 RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAF-LVVRGEPQG 3210
Score = 57.4 bits (137), Expect = 6e-08
Identities = 85/385 (22%), Positives = 141/385 (36%), Gaps = 52/385 (13%)
Query: 267 TGGEPAPSLTWVRSFGT-----LPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAK 321
T G P P +TW + + P VL G+L + +++ D+G Y C A N VG+ ++
Sbjct: 26 THGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSR 85
Query: 322 KSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKN----G 377
++ ++ I D + + G+ + + C P E+ W K+ G
Sbjct: 86 RAKLVVYVPPS-----IREDGRKANVSGMAGQSLTLECDANGFPVPEIV--WLKDAQLVG 138
Query: 378 RPLR-------------SSERMVITQTD---PDVSPGTTNLDIIDLKFTDFGTYTCVASL 421
PL R++ P + PG + + A L
Sbjct: 139 VPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGL 198
Query: 422 KGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRAD 481
G + + S PP++ ++ G +ELQC +G P P + W++ D
Sbjct: 199 AG---FEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK-D 254
Query: 482 KEVAMPDG-SMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPP 540
++ +P G +Q++ LRI G Y+C G + QL V PP
Sbjct: 255 RQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARD----FQLRVHAPP 310
Query: 541 AV--EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYT---- 594
+ E+ +D V + C R P +T W LL T YT
Sbjct: 311 TIWGSNETGEVAVMEDHLVQLLCEA-RGVPTPNIT--WFKDGALLPTS--TKVVYTRGGR 365
Query: 595 EYAVKSLSNENYGVYNCSIINEAGA 619
+ + + + GVY C N GA
Sbjct: 366 QLQLGRAQSSDAGVYTCKASNAVGA 390
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 125 bits (313), Expect = 2e-28
Identities = 156/586 (26%), Positives = 246/586 (41%), Gaps = 71/586 (12%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF-NETLRITNIQRHQGGRYYCKAE 113
G L LTC V+G P P + W K V L+++ +Q Q G Y C AE
Sbjct: 3139 GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAE 3198
Query: 114 NGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYE-RTVFLRCVANSNPPVRYSWR 172
N + A K V V V +S G A+E E + V L C A+ PP +W
Sbjct: 3199 N-TQAEARKDFVVAVL-----VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWL 3252
Query: 173 RGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVS 232
+ L G D G + F+ G + L LK LR D Y+C+A N +
Sbjct: 3253 KDGSPL--GQDMGPHL--RFYLDGGS--LVLKGLRASDAGAYTCVAH-----NPAGEDAR 3301
Query: 233 FRLSNKTASPSIKLLVD--DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP--EKT 288
N P+IK D +V PGE +T+VC G P ++W++ LP ++T
Sbjct: 3302 LHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPI-HVSWLKDGLPLPLSQRT 3360
Query: 289 VLNGG--TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKD 346
+L+G TL I + DAG ++C+A + G A ++ + V+ + P + D
Sbjct: 3361 LLHGSGHTLRISKVQLADAGIFTCVAASPAG-VADRNFTLQVQVPPV----LEPVEFQND 3415
Query: 347 DNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 406
+ G V++ C+ VP SW K+G PL S + P +L +
Sbjct: 3416 VVVVRGSLVELPCEARGVPLP--LVSWMKDGEPLLSQS----LEQGP-------SLQLEA 3462
Query: 407 LKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQ 466
+ D GTY+CVA + G + + + PP++ + + L G +EL C
Sbjct: 3463 VGAGDSGTYSCVA-VSEAGEARRHFQLTVME---PPHIEDSGQPTELSLTPGAPMELLCD 3518
Query: 467 VTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVK 526
G P+P I W + + + ++E+ R++ V +G+Y C G
Sbjct: 3519 AQGTPQPNITWHKDGQALT------RLENNSRATRVLRV--RDAGLYTCLAESPAG---- 3566
Query: 527 PREALVQLIVQYPPAV----EPAF-LEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNK 581
E ++ VQ PP + P F + + GQ + + C V A P +T+ R G
Sbjct: 3567 AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQ---LVLECSV-EAEPAPKITWH-RDGIV 3621
Query: 582 LLRTGQFDSQEYTEY-AVKSLSNENYGVYNCSIINEAGAGRCSFLV 626
L E + +++LS + G Y+C+ N AG+ +F V
Sbjct: 3622 LQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRV 3667
Score = 121 bits (303), Expect = 4e-27
Identities = 145/579 (25%), Positives = 235/579 (40%), Gaps = 63/579 (10%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTK---TAGSASDRFQDSSVFNETLRITNIQRHQGGR 107
T+ GET L+C V G + W + +++ R + + + +L I+ I GGR
Sbjct: 527 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRV--AQLADLSLEISGIIPTDGGR 584
Query: 108 YYCKAENGLGSPAIKSIRVDVYYL--DDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNP 165
Y C A N G R V+ L + P V++H S + F V + C A+ P
Sbjct: 585 YQCVASNANGVT-----RASVWLLVREAPQVSIHTS----SQHFSQGVEVKVSCSASGYP 635
Query: 166 PVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCN 225
SW R + L + S V+ QG + P+D NYSC A+ N
Sbjct: 636 TPHISWSRESQALQEDSRIHVDAQGTLIIQG---------VAPEDAGNYSCQAT--NEVG 684
Query: 226 IPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL- 284
+ V+ T PS+ V+ ++V GE LVC +G P P + W R +
Sbjct: 685 TDQETVTLYY---TDPPSVSA-VNAVVLVAVGEEAVLVCEASG-VPPPRVIWYRGGLEMI 739
Query: 285 --PEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDP 342
PE + + G L IPA DAGTY+C A N +G+ + + + A + +T P
Sbjct: 740 LAPEGS--SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQ-----LTELP 792
Query: 343 YHKDDNIQIGREVKISCQVEAVPSEELTFSWFK-NGRPLRSSERMVITQTDPDVSPGTTN 401
+D +++GR ++C+ P +T W + +G+PL R+ + P +
Sbjct: 793 --RDVTVELGRSALLACRATGRPPPTVT--WRRGDGQPL--GLRLGAGRGSRSRQPDSGV 846
Query: 402 LDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLV-TREGDT 460
L + D Y C A G + + I + PP + +P V EG
Sbjct: 847 LFFESVAPEDQAPYVCEARNVFGKVQAEAR--LIVTGHAPPQIA---SSAPTVRVLEGQP 901
Query: 461 IELQCQV-TGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQ 519
+ L C V G+P P W + + +P GS DG+L + +E +G Y C +
Sbjct: 902 VSLPCIVLAGRPLPERHWLKDGRP--LPPGSRHSIRADGSLHLDRALQEHAGRYSCVATN 959
Query: 520 YNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLG 579
G + V+L+VQ PP + P + ++ C V P +T+
Sbjct: 960 TAGSQHRD----VELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVPAPTITWTKETN 1014
Query: 580 NKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAG 618
R ++ + + S ++ G Y C+ N G
Sbjct: 1015 ALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVG 1053
Score = 119 bits (297), Expect = 2e-26
Identities = 144/592 (24%), Positives = 236/592 (39%), Gaps = 67/592 (11%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDS-SVFNETLRITNIQRHQGGRYYC 110
+ E ++ L CL +G P P + W K S + SV LRI Q G Y C
Sbjct: 1897 VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRC 1956
Query: 111 KAENGLGSPAIK-SIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRY 169
A N GS ++ +RV+V P +T+ S+ V L C A P
Sbjct: 1957 VASNVAGSTELRYGLRVNV----PPRITLPPSL---PGPVLVNTPVRLTCNATGAPSPTL 2009
Query: 170 SWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDK 229
W + + G++++ ++L L + R D YSC+A + D
Sbjct: 2010 MWLKDGNPVSPAGTPGLQVFP------GGRVLTLASARASDSGRYSCVAVSAVGEDRQDV 2063
Query: 230 MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV 289
++ + PSI L + + V E++ L C + P P L+W + L +
Sbjct: 2064 VLQVHM-----PPSI-LGEELNVSVVANESVALEC-QSHAMPPPVLSWWKDGRPLEPRPG 2116
Query: 290 L----NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITP-DPYH 344
+ + L + DAG Y+C A N G+ ++K N+ V W+ P P
Sbjct: 2117 VHLSADKALLQVDRADVWDAGHYTCEALNQAGH-SEKHYNLNV--------WVAPVFPLR 2167
Query: 345 KDDNIQI--GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNL 402
+ + + G +SC+ VP ++ SW K+G+PL + VS L
Sbjct: 2168 ESHTLTVREGHPTSLSCECRGVPFPKI--SWRKDGQPLPGEGAGL-----QHVSAVGRLL 2220
Query: 403 DIIDLKFTDFGTYTCVAS-LKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTI 461
+ + GTYTC S + G D+ ++V+ VPP + P+E V+ D +
Sbjct: 2221 YLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVH-----VPPQIAGPREPPTQVSVVQDGV 2275
Query: 462 -ELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQY 520
L+C TGKP P + W R + V G +Q+++ +L + +G Y C
Sbjct: 2276 ATLECNATGKPPPTVTWERDGQPVGAELG-LQLQNQGQSLHVERAQAAHTGRYSCVAENL 2334
Query: 521 NGFNVKPREALVQLIVQYPPA----VEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEW 576
G E +L V PP ++P I +T+ C + P + W
Sbjct: 2335 AG----RAERKFELSVLVPPELIGDLDP-LTNITAALHSPLTLLCEAMGIPPPAI---RW 2386
Query: 577 RLGNKLLRTGQFDSQEYTEYAVK--SLSNENYGVYNCSIINEAGAGRCSFLV 626
G + + G+ + +K ++ G+Y+C NEAG R +F V
Sbjct: 2387 FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSV 2438
Score = 117 bits (292), Expect = 7e-26
Identities = 151/622 (24%), Positives = 253/622 (40%), Gaps = 83/622 (13%)
Query: 43 ERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNET--LRITNI 100
E ++ T+ + L C P P I W K G+ + ++ + T L+I N
Sbjct: 2544 EDSADEEVTVTVNNPISLICEALAFPSPNITWMKD-GAPFEASRNIQLLPGTHGLQILNA 2602
Query: 101 QRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEA---KEQFYYERTVFL 157
Q+ G+Y C N LG A+K+ V+V L P ++ +GE + + T+ L
Sbjct: 2603 QKEDAGQYTCVVTNELGE-AVKNYHVEV--LIPPSISKDDPLGEVGVKEVKTKVNSTLTL 2659
Query: 158 RCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCI 217
C + + PP W + + + S V GE ++L+++ + D Y C+
Sbjct: 2660 ECESWAVPPPTIRWYKDGQPVTPSSRLQV--------LGEGRLLQIQPTQVSDSGRYLCV 2711
Query: 218 ASVRNVC------------------NIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEA 259
A+ NV + D +F + ++ + IV N
Sbjct: 2712 AT--NVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVEN--NP 2767
Query: 260 ITLVCVTTGGEPAPSLTWVRSFGTL---PEKTVLNGG-TLTIPAITSDDAGTYSCIANNN 315
L C T P P LTW R L E +VL GG L IP + +++AG YSC A+N
Sbjct: 2768 AYLYC-DTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNE 2826
Query: 316 VGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFK 375
VG +++ I D + + + +S Q A+ + T SW +
Sbjct: 2827 VGEDWLHYELLVLTPPV-----ILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQ 2881
Query: 376 NGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDI-SIDVN 434
NG P S R+ + + D V L + + D +Y CVA + G + ++ V
Sbjct: 2882 NGLPFSPSPRLQVLE-DGQV------LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ 2934
Query: 435 ISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQME 494
VPP + + + ++ L C V P P + W + + +++ + +
Sbjct: 2935 -----VPPRI-AGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLP 2988
Query: 495 SYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPA------FLE 548
TL++ SGMY C+ G + K LVQL V PPA A +
Sbjct: 2989 G-THTLQLGRARLSDSGMYTCEALNAAGRDQK----LVQLSVLVPPAFRQAPRGPQDAVL 3043
Query: 549 IRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL---RTGQFDSQEYTEYAVKSLSNEN 605
+R G D++V +SC A P +T+ ++ G L+ RT + E +S++
Sbjct: 3044 VRVG-DKAV-LSCET-DALPEPTVTW-YKDGQPLVLAQRTQALRGGQRLEIQEAQVSDK- 3098
Query: 606 YGVYNCSIINEAGAGRCSFLVT 627
G+Y+C + N AG +F +T
Sbjct: 3099 -GLYSCKVSNVAGEAVRTFTLT 3119
Score = 116 bits (291), Expect = 9e-26
Identities = 145/596 (24%), Positives = 238/596 (39%), Gaps = 86/596 (14%)
Query: 50 YTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF-NETLRITNIQRHQGGRY 108
+T+ + LTC TG P P + W+K R V + L I GRY
Sbjct: 3866 FTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRY 3925
Query: 109 YCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
C A N G + V + PVV S+ A E V L C A+ P
Sbjct: 3926 TCSARNSAG---VAHKHVFLTVQASPVVKPLPSVVRA----VAEEEVLLPCEASGIPRPT 3978
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
+W++ +G + + G+ L++ + P+D NY CIA
Sbjct: 3979 ITWQK------EGLNVATGVSTQVLPGGQ---LRIAHASPEDAGNYLCIA---------- 4019
Query: 229 KMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTG----------GEPAPSLTWV 278
+ S +A +L+V P V+ G + + T G G P P++TW
Sbjct: 4020 -----KNSAGSAMGKTRLVVQVPPVIENG--LPDLSTTEGSHAFLPCKARGSPEPNITWD 4072
Query: 279 RS----FGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKG 334
+ G + T+ G L + + DAGTY+C A N VG A++ ++ + L
Sbjct: 4073 KDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR-ARRRVHLTILVLPV- 4130
Query: 335 RFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPD 394
F P D ++++G + + C P+ + W N RP+ +++ D
Sbjct: 4131 -FTTLPG----DRSLRLGDRLWLRCAARGSPTPRI--GWTVNDRPVTEG----VSEQD-- 4177
Query: 395 VSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLV 454
G + L + D GTY C A + G +S V++ + V + S LV
Sbjct: 4178 ---GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF-VHVKEAPVLQG----EAFSYLV 4229
Query: 455 TREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYR 514
G +I+L C V G P P I W + + + ++ + +G+L I R+ +G Y+
Sbjct: 4230 EPVGGSIQLDCVVRGDPVPDIHWIK--DGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQ 4287
Query: 515 CQTSQYNGFNVKPREALVQLIVQYPPA--VEPAFLEIRQGQDRSVTMSCRVLRAYPIRVL 572
C G K +V L++Q P VEP + +R G D V + C +A
Sbjct: 4288 CLAENEMGVAKK----VVILVLQSAPVFQVEPQDMTVRSGDD--VALRC---QATGEPTP 4338
Query: 573 TYEW-RLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRC-SFLV 626
T EW + G L + + + ++++ + G Y+C N G+ +FLV
Sbjct: 4339 TIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLV 4394
Score = 115 bits (288), Expect = 2e-25
Identities = 149/576 (25%), Positives = 219/576 (38%), Gaps = 123/576 (21%)
Query: 23 VYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTA---- 78
VY PP++R G N+ G++L L C G P P+I W K A
Sbjct: 1295 VYVPPSIR--EDGRKANVSG----------MAGQSLTLECDANGFPVPEIVWLKDAQLVG 1342
Query: 79 ------GSASD---------RFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKS 123
G D R D ++L IQ G Y C+AEN G+
Sbjct: 1343 VPLGWAGYGWDLGWGQVGGHRLLDEG---QSLHFPRIQEGDSGLYSCRAENQAGTA---- 1395
Query: 124 IRVDVYYLDDPVVTVHQSIGEAKEQFYYERT---VFLRCVANSNPPVRYSWRRGQEVLLQ 180
+ D + L V+T +G Q V L+C + P + W + ++ +L
Sbjct: 1396 -QRDFHLL---VLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLP 1451
Query: 181 GSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRL----- 235
G Q + ++L++ D Y C+A D +
Sbjct: 1452 GGPH-------LQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIW 1504
Query: 236 -SNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL---- 290
SN+T + V + L+C G P P++TW + LP T +
Sbjct: 1505 GSNETGE----------VAVMEDHLVQLLCEARG-VPTPNITWFKDGALLPTSTKVVYTR 1553
Query: 291 NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKK-----GRFWITPDPYHK 345
G L + S DAG Y+C A+N VG A+K+T + V GR ++
Sbjct: 1554 GGRQLQLGRAQSSDAGVYTCKASNAVG-AAEKATRLDVYVPPTIEGAGGRPYVV------ 1606
Query: 346 DDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDV----SPGTTN 401
GR V + C PS T SW G P+ S + +TD V SPG +
Sbjct: 1607 --KAVAGRPVALECVARGHPSP--TLSWHHEGLPVAESNESRL-ETDGSVLRLESPGEAS 1661
Query: 402 LDIIDLKFTDFGTYTCVASLKGG-GISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDT 460
G Y+CVAS G + S++V VPP L V + + T G
Sbjct: 1662 S----------GLYSCVASSPAGEAVLQYSVEVQ-----VPPQLLVAEGLGQVTTIVGQP 1706
Query: 461 IELQCQVTGKPKPIILW---SRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQT 517
+EL CQ +G P P I W R +E+A +Q+ S TL I +V + SG++ CQ
Sbjct: 1707 LELPCQASGSPVPTIQWLQNGRPAEELA----GVQVASQGTTLHIDHVELDHSGLFACQA 1762
Query: 518 SQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQ 553
+ N E V + ++ P V LE+ GQ
Sbjct: 1763 T--NEAGTAGAEVEVSVHGEWAPGV----LEVPIGQ 1792
Score = 112 bits (280), Expect = 2e-24
Identities = 146/608 (24%), Positives = 242/608 (39%), Gaps = 97/608 (15%)
Query: 48 RVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGR 107
RV + GE L+L C+ G+P PQ+ W+K R SV +R ++ GR
Sbjct: 1127 RVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGSVHFAAIRTSD-----AGR 1181
Query: 108 YYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPV 167
Y C+A N G + + V++ L+ P ++ G + L C A P
Sbjct: 1182 YRCEASNSAG---VDAWEVELRVLEPPHWGADETSGLLER--VAGENASLPCPARGTPKP 1236
Query: 168 RYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVR-NVCNI 226
+ +WR+G GV + E +G L L ++ P D +Y C A+ +
Sbjct: 1237 QVTWRKGPSSEPLHGQPGVAVLE----EGS---LFLASVSPADSGDYECQATNEVGSTSR 1289
Query: 227 PDKMVSFRLSNKTASPSIKLLVDDPIVVN----PGEAITLVCVTTGGEPAPSLTWVR--- 279
K+V + PSI+ +D N G+++TL C G P P + W++
Sbjct: 1290 RAKLVVY------VPPSIR---EDGRKANVSGMAGQSLTLEC-DANGFPVPEIVWLKDAQ 1339
Query: 280 ---------------SFGTLPEKTVLN-GGTLTIPAITSDDAGTYSCIANNNVGNPAKKS 323
+G + +L+ G +L P I D+G YSC A N G A++
Sbjct: 1340 LVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGT-AQRD 1398
Query: 324 TNIIVRALKKGRFWITPDPYHKDDNIQ-----IGREVKISCQVEAVPSEELTFSWFKNGR 378
+++V +TP Q G +V++ C VP+ ++ W K+ +
Sbjct: 1399 FHLLV---------LTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQV--EWTKDRQ 1447
Query: 379 PLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVA-SLKGGGISDISIDVNISS 437
P+ + Q D V L I D G Y CVA S G D + V+
Sbjct: 1448 PVLPGGPHLQVQEDGQV------LRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVH--- 1498
Query: 438 STVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYD 497
PP + E + E ++L C+ G P P I W + +P + + +
Sbjct: 1499 --APPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFK--DGALLPTSTKVVYTRG 1554
Query: 498 G-TLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAF---LEIRQGQ 553
G L++ +G+Y C+ S G E +L V PP +E A ++
Sbjct: 1555 GRQLQLGRAQSSDAGVYTCKASNAVG----AAEKATRLDVYVPPTIEGAGGRPYVVKAVA 1610
Query: 554 DRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAV---KSLSNENYGVYN 610
R V + C V R +P L++ G + + +S+ T+ +V +S + G+Y+
Sbjct: 1611 GRPVALEC-VARGHPSPTLSWHHE-GLPVAESN--ESRLETDGSVLRLESPGEASSGLYS 1666
Query: 611 CSIINEAG 618
C + AG
Sbjct: 1667 CVASSPAG 1674
Score = 111 bits (277), Expect = 4e-24
Identities = 132/550 (24%), Positives = 221/550 (40%), Gaps = 72/550 (13%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSASDR---FQDSSVFNETLRITNIQRHQGGR 107
T+REG L+C G P P+I W K Q S L + Q Q G
Sbjct: 2173 TVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 2232
Query: 108 YYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPV 167
Y C+ N +G+ + + ++++V+ P + + L C A PP
Sbjct: 2233 YTCECSNVVGNSS-QDLQLEVHV---PPQIAGPREPPTQVSVVQDGVATLECNATGKPPP 2288
Query: 168 RYSWRR-GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNI 226
+W R GQ V G++ G+++ Q + + L ++ + YSC+A N+
Sbjct: 2289 TVTWERDGQPV---GAELGLQL------QNQGQSLHVERAQAAHTGRYSCVA--ENLAGR 2337
Query: 227 PDKMVSFRLSNKTASPSIKLLVDDP---IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGT 283
++ F LS I L DP I +TL+C G P P++ W R G
Sbjct: 2338 AER--KFELSVLVPPELIGDL--DPLTNITAALHSPLTLLCEAM-GIPPPAIRWFR--GE 2390
Query: 284 LP----EKTVL--NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFW 337
P E T L G L + D+G YSC+A+N G A+++ ++ V
Sbjct: 2391 EPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGE-ARRNFSVEV--------- 2440
Query: 338 ITPDPYHKDDNIQI-----GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTD 392
+ P +D ++ G+ + C V P +LT WFK+GRPL +
Sbjct: 2441 LVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLT--WFKDGRPLARGDA------- 2491
Query: 393 PDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKS- 451
+SP L ++ + G Y+C+A+ + + + +S P L ++ +
Sbjct: 2492 HHISPDGVLLQVLQANLSSAGHYSCIAA---NAVGEKTKHFQLSVLLAPTILGGAEDSAD 2548
Query: 452 -PLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT--LRIVNVSRE 508
+ + I L C+ P P I W K+ A + S ++ GT L+I+N +E
Sbjct: 2549 EEVTVTVNNPISLICEALAFPSPNITWM---KDGAPFEASRNIQLLPGTHGLQILNAQKE 2605
Query: 509 MSGMYRCQTSQYNGFNVKPREALVQL---IVQYPPAVEPAFLEIRQGQDRSVTMSCRVLR 565
+G Y C + G VK V + I + P E E++ + ++T+ C
Sbjct: 2606 DAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWA 2665
Query: 566 AYPIRVLTYE 575
P + Y+
Sbjct: 2666 VPPPTIRWYK 2675
Score = 111 bits (277), Expect = 4e-24
Identities = 146/599 (24%), Positives = 234/599 (39%), Gaps = 84/599 (14%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF--NETLRITNIQRHQGGRYY 109
+R G+ L+C P P + W K G Q + + L I Q G Y
Sbjct: 3044 VRVGDKAVLSCETDALPEPTVTWYKD-GQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYS 3102
Query: 110 CKAENGLGSPA---IKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPP 166
CK N G +++V + + TV Q G + L C + P
Sbjct: 3103 CKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGS---------PLVLTCDVSGVPA 3153
Query: 167 VRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNI 226
+W + + + + GV ++G L+L L+P Y+C+A
Sbjct: 3154 PTVTWLKDRMPVESSAVHGV------VSRGGR--LQLSRLQPAQAGTYTCVAENTQAEAR 3205
Query: 227 PDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPE 286
D +V+ ++ + S V V G+ + L C G+P P + W++ L +
Sbjct: 3206 KDFVVAVLVAPRIRSSG----VAREHHVLEGQEVRLDC-EADGQPPPDVAWLKDGSPLGQ 3260
Query: 287 ------KTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKST-NIIVRALKK----GR 335
+ L+GG+L + + + DAG Y+C+A+N G A+ T N++V K G
Sbjct: 3261 DMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGS 3320
Query: 336 FWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDV 395
+ P G V + C V P + SW K+G PL S+R ++
Sbjct: 3321 GTLVSRP---------GELVTMVCPVRGSP--PIHVSWLKDGLPLPLSQRTLLH------ 3363
Query: 396 SPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVT 455
G T L I ++ D G +TCVA+ G++D + + + VPP L + ++ +V
Sbjct: 3364 GSGHT-LRISKVQLADAGIFTCVAA-SPAGVADRNFTLQVQ---VPPVLEPVEFQNDVVV 3418
Query: 456 REGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRC 515
G +EL C+ G P P++ W + D E + Q S L++ V SG Y C
Sbjct: 3419 VRGSLVELPCEARGVPLPLVSWMK-DGEPLLSQSLEQGPS----LQLEAVGAGDSGTYSC 3473
Query: 516 QTSQYNGFNVKPREALVQLIVQYPPAVE----PAFLEIRQGQDRSVTMSCRVLRAYPIRV 571
G QL V PP +E P L + G + + P
Sbjct: 3474 VAVSEAG----EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDA---QGTPQPN 3526
Query: 572 LTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKA 630
+T+ + G L R E A + L + G+Y C + AGA SF V +A
Sbjct: 3527 ITWH-KDGQALTRL------ENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQA 3578
Score = 110 bits (276), Expect = 5e-24
Identities = 135/592 (22%), Positives = 244/592 (41%), Gaps = 77/592 (13%)
Query: 57 TLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF----NETLRITNIQRHQGGRYYCKA 112
++ L C V HP P++ W K + + S VF TL++ + G Y C+A
Sbjct: 2954 SVSLPCDVHAHPNPEVTWYKDSQALS---LGEEVFLLPGTHTLQLGRARLSDSGMYTCEA 3010
Query: 113 ENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERT---VFLRCVANSNPPVRY 169
N G K +++ V V + + R L C ++ P
Sbjct: 3011 LNAAGRDQ-KLVQLSVL-----VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTV 3064
Query: 170 SWRR-GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
+W + GQ ++L + + +G + L+++ + D YSC V N+
Sbjct: 3065 TWYKDGQPLVLAQRTQAL--------RGGQR-LEIQEAQVSDKGLYSC-----KVSNVAG 3110
Query: 229 KMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT 288
+ V P+ + + + G + L C G PAP++TW++ +
Sbjct: 3111 EAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTC-DVSGVPAPTVTWLKDRMPVESSA 3169
Query: 289 V----LNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH 344
V GG L + + AGTY+C+A N A+ + +V L R I
Sbjct: 3170 VHGVVSRGGRLQLSRLQPAQAGTYTCVAEN---TQAEARKDFVVAVLVAPR--IRSSGVA 3224
Query: 345 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTT---- 400
++ ++ G+EV++ C+ + P ++ +W K+G PL D+ P
Sbjct: 3225 REHHVLEGQEVRLDCEADGQPPPDV--AWLKDGSPL-----------GQDMGPHLRFYLD 3271
Query: 401 --NLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKS-PLVTRE 457
+L + L+ +D G YTCVA G + + VN+ VPP + + S LV+R
Sbjct: 3272 GGSLVLKGLRASDAGAYTCVAHNPAGEDARLH-TVNV---LVPPTIKQGADGSGTLVSRP 3327
Query: 458 GDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQT 517
G+ + + C V G P + W + + + ++ + TLRI V +G++ C
Sbjct: 3328 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTL-LHGSGHTLRISKVQLADAGIFTCVA 3386
Query: 518 SQYNGFNVKPREALVQLIVQYPPAVEPAFL--EIRQGQDRSVTMSCRVLRAYPIRVLTYE 575
+ G V R +Q VQ PP +EP ++ + V + C R P+ ++++
Sbjct: 3387 ASPAG--VADRNFTLQ--VQVPPVLEPVEFQNDVVVVRGSLVELPCEA-RGVPLPLVSW- 3440
Query: 576 WRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 627
+ G LL ++ ++++ + G Y+C ++EAG R F +T
Sbjct: 3441 MKDGEPLLSQ---SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 3489
Score = 108 bits (270), Expect = 2e-23
Identities = 136/552 (24%), Positives = 225/552 (40%), Gaps = 81/552 (14%)
Query: 95 LRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERT 154
L+I + G Y C A N L + + + + V +V + G + +
Sbjct: 1850 LQIEKVDLRDEGIYTCAATN-LAGESKREVALKV------LVPPNIEPGPVNKAVLENAS 1902
Query: 155 VFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANY 214
V L C+A+ PP SW +G + + V + + ++L+++ + D +Y
Sbjct: 1903 VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSV--------DGRVLRIEQAQLSDAGSY 1954
Query: 215 SCIASVRNVCNIPDKMVSFRLSNKTASPSIKL--LVDDPIVVNPGEAITLVCVTTGGEPA 272
C+AS NV + R++ P I L + P++VN + L C TG P+
Sbjct: 1955 RCVAS--NVAGSTELRYGLRVN---VPPRITLPPSLPGPVLVNT--PVRLTCNATGA-PS 2006
Query: 273 PSLTWVRSFGTL-----PEKTVLNGG-TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNI 326
P+L W++ + P V GG LT+ + + D+G YSC+A + VG + ++
Sbjct: 2007 PTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQ---DV 2063
Query: 327 IVRALKKGRFWITPDPYHKDDNIQI--GREVKISCQVEAVPSEELTFSWFKNGRPLRSSE 384
+++ + P ++ N+ + V + CQ A+P L SW+K+GRPL
Sbjct: 2064 VLQV------HMPPSILGEELNVSVVANESVALECQSHAMPPPVL--SWWKDGRPLE--- 2112
Query: 385 RMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNL 444
+ +S L + D G YTC A L G S+ ++N+ + V P
Sbjct: 2113 ----PRPGVHLSADKALLQVDRADVWDAGHYTCEA-LNQAGHSEKHYNLNVWVAPVFP-- 2165
Query: 445 TVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVN 504
+E L REG L C+ G P P I W + + + +Q S G L +
Sbjct: 2166 --LRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLG 2223
Query: 505 VSR-EMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV----EPAFLEIRQGQDRSVTM 559
++ G Y C+ S G + + +QL V PP + EP ++ QD T+
Sbjct: 2224 QAQLAQEGTYTCECSNVVGNSSQD----LQLEVHVPPQIAGPREPP-TQVSVVQDGVATL 2278
Query: 560 SCRVLRAYPIRVLTYE-------WRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCS 612
C P +T+E LG +L GQ E + A + G Y+C
Sbjct: 2279 ECNA-TGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAA-------HTGRYSCV 2330
Query: 613 IINEAGAGRCSF 624
N AG F
Sbjct: 2331 AENLAGRAERKF 2342
Score = 108 bits (270), Expect = 2e-23
Identities = 134/598 (22%), Positives = 230/598 (38%), Gaps = 93/598 (15%)
Query: 48 RVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF---NETLRITNIQRHQ 104
R + + EG+ + L C G P P + W K F +L + ++
Sbjct: 3225 REHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASD 3284
Query: 105 GGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSN 164
G Y C A N PA + R+ + P + G V + C +
Sbjct: 3285 AGAYTCVAHN----PAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGS 3340
Query: 165 PPVRYSWRR-------GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCI 217
PP+ SW + Q LL GS G T L++ ++ D ++C+
Sbjct: 3341 PPIHVSWLKDGLPLPLSQRTLLHGS-------------GHT--LRISKVQLADAGIFTCV 3385
Query: 218 ASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTW 277
A+ + + D+ + ++ ++ D +VV G + L C G P P ++W
Sbjct: 3386 AA--SPAGVADRNFTLQVQVPPVLEPVEFQND--VVVVRGSLVELPCEARG-VPLPLVSW 3440
Query: 278 VRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFW 337
++ L +++ G +L + A+ + D+GTYSC+A + G A++ + V
Sbjct: 3441 MKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGE-ARRHFQLTVM-------- 3491
Query: 338 ITPDPYHKDD-------NIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQ 390
+P H +D ++ G +++ C + P +T W K+G+ L E
Sbjct: 3492 ---EPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT--WHKDGQALTRLEN----- 3541
Query: 391 TDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEK 450
+ T + L+ D G YTC+A G I + S V + + PPN+ P+
Sbjct: 3542 -----NSRATRV----LRVRDAGLYTCLAESPAGAI-EKSFRVRVQA---PPNIVGPRGP 3588
Query: 451 SPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMS 510
+V + L+C V +P P I W R D V D Q L++ +S S
Sbjct: 3589 RFVVGLAPGQLVLECSVEAEPAPKITWHR-DGIVLQEDAHTQFPERGRFLQLQALSTADS 3647
Query: 511 GMYRCQTSQYNG-----FNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLR 565
G Y C G F V+ V I PPAV + +++ + C +
Sbjct: 3648 GDYSCTARNAAGSTSVAFRVEIH--TVPTIRSGPPAVNVSV-------NQTALLPC---Q 3695
Query: 566 AYPIRVLTYEWRLGNKLL--RTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGR 621
A + WR L R+ +F+ ++ + ++ G Y C N AG+ R
Sbjct: 3696 ADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR 3753
Score = 107 bits (268), Expect = 4e-23
Identities = 127/478 (26%), Positives = 186/478 (38%), Gaps = 67/478 (14%)
Query: 49 VYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRY 108
V + E E L L C +G PRP I W K + + + LRI + G Y
Sbjct: 3957 VRAVAEEEVL-LPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY 4015
Query: 109 YCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
C A+N GS A+ R+ V PV+ E + FL C A +P
Sbjct: 4016 LCIAKNSAGS-AMGKTRLVVQV--PPVIENGLPDLSTTEGSH----AFLPCKARGSPEPN 4068
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
+W + + + K FT + L +KNL QD Y+C A N
Sbjct: 4069 ITWDKDGQPVSGAEGK--------FTIQPSGELLVKNLEGQDAGTYTCTAE--NAVGRAR 4118
Query: 229 KMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT 288
+ V + P L D + G+ + L C G P P + W + + E
Sbjct: 4119 RRVHLTI---LVLPVFTTLPGDRSL-RLGDRLWLRCAARGS-PTPRIGWTVNDRPVTEGV 4173
Query: 289 VLN--GGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRA--LKKGRFWITPDPYH 344
G TL A++ +D+GTY C A N VG S + A L+ F +P
Sbjct: 4174 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP-- 4231
Query: 345 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDI 404
+G +++ C V P ++ W K+G PLR S Q +L I
Sbjct: 4232 ------VGGSIQLDCVVRGDPVPDI--HWIKDGLPLRGSHLRHQLQNG--------SLTI 4275
Query: 405 IDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQ 464
+ D G Y C+A + G + I V S+ P PQ+ + R GD + L+
Sbjct: 4276 HRTERDDAGRYQCLAENEMGVAKKVVILVLQSA---PVFQVEPQD---MTVRSGDDVALR 4329
Query: 465 CQVTGKPKPIILWSRADKEV-------AMPDGSMQMESYDGTLRIVNVSREMSGMYRC 515
CQ TG+P P I W +A + + +PDGS+ +E NV +G Y C
Sbjct: 4330 CQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLE---------NVETGDAGTYDC 4378
Score = 102 bits (253), Expect = 2e-21
Identities = 130/570 (22%), Positives = 217/570 (38%), Gaps = 82/570 (14%)
Query: 69 RPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKS--IRV 126
R Q+R + FQ+S N + I + + G Y C A + G+ K+ +
Sbjct: 457 RLQLRRGEARLGEERHFQESG--NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVT 514
Query: 127 DVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGV 186
D P V S GE T L C P +W R VL + +
Sbjct: 515 DPPPQLVPAPNVTVSPGE---------TAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVA 565
Query: 187 EIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKL 246
++ + L++ + P D Y C+AS N + R +P + +
Sbjct: 566 QLAD--------LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR-----EAPQVSI 612
Query: 247 LVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN---GGTLTIPAITSD 303
+ G + + C + G P P ++W R L E + ++ GTL I + +
Sbjct: 613 HTSSQHF-SQGVEVKVSC-SASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPE 670
Query: 304 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDN----IQIGREVKISC 359
DAG YSC A N VG + T + T P N + +G E + C
Sbjct: 671 DAGNYSCQATNEVGTDQETVT-----------LYYTDPPSVSAVNAVVLVAVGEEAVLVC 719
Query: 360 QVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVA 419
+ VP + W++ G M++ P+ S + L I + D GTYTC A
Sbjct: 720 EASGVPPPRVI--WYRGGL------EMILA---PEGS-SSGKLRIPAAQERDAGTYTCRA 767
Query: 420 SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSR 479
+ D S ++ ++ P +P++ + G + L C+ TG+P P + W R
Sbjct: 768 V---NELGDASAEIQLAVGHAPQLTELPRD---VTVELGRSALLACRATGRPPPTVTWRR 821
Query: 480 ADKE-----VAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQL 534
D + + GS + G L +V+ E Y C+ N F EA + +
Sbjct: 822 GDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEAR--NVFGKVQAEARLIV 879
Query: 535 IVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTG-----QFD 589
PP + + +R + + V++ C VL P+ W + L G + D
Sbjct: 880 TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLP--ERHWLKDGRPLPPGSRHSIRAD 937
Query: 590 SQEYTEYAVKSLSNENYGVYNCSIINEAGA 619
+ + A++ E+ G Y+C N AG+
Sbjct: 938 GSLHLDRALQ----EHAGRYSCVATNTAGS 963
Score = 101 bits (251), Expect = 4e-21
Identities = 122/495 (24%), Positives = 194/495 (39%), Gaps = 84/495 (16%)
Query: 54 EGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAE 113
+G ++++C +G+P P I W++ + + + + TL I + G Y C+A
Sbjct: 621 QGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQAT 680
Query: 114 NGLGSPAIKSIRVDVYYLDDPVVT-----VHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
N +G+ V +YY D P V+ V ++GE L C A+ PP R
Sbjct: 681 NEVGTD---QETVTLYYTDPPSVSAVNAVVLVAVGEE---------AVLVCEASGVPPPR 728
Query: 169 YSWRRGQ-EVLL--QGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCN 225
W RG E++L +GS G L++ + +D Y+C R V
Sbjct: 729 VIWYRGGLEMILAPEGSSSGK--------------LRIPAAQERDAGTYTC----RAVNE 770
Query: 226 IPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL- 284
+ D +L+ A +L D + V G + L C TG P P++TW R G
Sbjct: 771 LGDASAEIQLAVGHAPQLTELPRD--VTVELGRSALLACRATG-RPPPTVTWRRGDGQPL 827
Query: 285 ---------PEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGR 335
+ G L ++ +D Y C A N G ++ I+
Sbjct: 828 GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP--- 884
Query: 336 FWITPDPYHKDDNIQI--GREVKISCQVEA---VPSEELTFSWFKNGRPLRSSERMVITQ 390
P +++ G+ V + C V A +P W K+GRPL R I
Sbjct: 885 ----PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH----WLKDGRPLPPGSRHSIR- 935
Query: 391 TDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS-DISIDVNISSSTVPPNLTVPQE 449
+ G+ +LD + G Y+CVA+ G D+ + V VPP +
Sbjct: 936 -----ADGSLHLDRALQEHA--GRYSCVATNTAGSQHRDVELVVQ-----VPPR--IHPT 981
Query: 450 KSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREM 509
+ +T EG L C +G P P I W++ + G S +GTL I S +
Sbjct: 982 ATHHITNEGVPASLPCVASGVPAPTITWTK-ETNALTSRGPHYNVSKEGTLLIAQPSAQD 1040
Query: 510 SGMYRCQTSQYNGFN 524
+G Y C + GF+
Sbjct: 1041 AGAYVCTATNTVGFS 1055
Score = 99.8 bits (247), Expect = 1e-20
Identities = 139/579 (24%), Positives = 219/579 (37%), Gaps = 74/579 (12%)
Query: 58 LELTCLVTGHPRPQIRWTKTA----GSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAE 113
L L C V P P+I W + A +F + F L++ + G Y C A
Sbjct: 3599 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF---LQLQALSTADSGDYSCTAR 3655
Query: 114 NGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRR 173
N GS ++ + RV+++ V T+ G +T L C A+ P SWR+
Sbjct: 3656 NAAGSTSV-AFRVEIH----TVPTIRS--GPPAVNVSVNQTALLPCQADGVPAPLVSWRK 3708
Query: 174 GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSF 233
+ L S P F L+++ + QD +Y C+AS N +
Sbjct: 3709 DRVPLDPRS--------PRFEILPEGSLRIQPVLAQDAGHYLCLAS--NSAGSDRQGRDL 3758
Query: 234 RLSNKTA---SPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT-- 288
R+ A SPS L + P EA G P P + W + L +
Sbjct: 3759 RVLEPPAIAPSPSNLTLTAHTPALLPCEA--------SGSPKPLVVWWKDGQKLDFRLQQ 3810
Query: 289 ----VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH 344
+L L + A D+ + C+ +N VG A + + V I D
Sbjct: 3811 GAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGE-AHRLYQVTVHVPPT----IADD--Q 3863
Query: 345 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDI 404
D + + V ++C +P+ T SW K G L + + VSP L+I
Sbjct: 3864 TDFTVTMMAPVVLTCHSTGIPAP--TVSWSKAGAQLGARG------SGYRVSPSGA-LEI 3914
Query: 405 IDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTRE--GDTIE 462
G YTC A G++ + + + +S V L P V R + +
Sbjct: 3915 GQALPIHAGRYTCSAR-NSAGVAHKHVFLTVQASPVVKPL-------PSVVRAVAEEEVL 3966
Query: 463 LQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNG 522
L C+ +G P+P I W + VA + + G LRI + S E +G Y C G
Sbjct: 3967 LPCEASGIPRPTITWQKEGLNVATGVSTQVLPG--GQLRIAHASPEDAGNYLCIAKNSAG 4024
Query: 523 FNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKL 582
+ +L+VQ PP +E ++ + + C+ R P +T++
Sbjct: 4025 SAM----GKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA-RGSPEPNITWDKDGQPVS 4079
Query: 583 LRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGR 621
G+F Q E VK+L ++ G Y C+ N G R
Sbjct: 4080 GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRAR 4118
Score = 97.1 bits (240), Expect = 7e-20
Identities = 142/630 (22%), Positives = 227/630 (36%), Gaps = 108/630 (17%)
Query: 49 VYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRY 108
V + GE L C +G P P++ W + G + LRI Q G Y
Sbjct: 706 VVLVAVGEEAVLVCEASGVPPPRVIWYR--GGLEMILAPEGSSSGKLRIPAAQERDAGTY 763
Query: 109 YCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYE--RTVFLRCVANSNPP 166
C+A N LG S + + P +T E E R+ L C A PP
Sbjct: 764 TCRAVNELGD---ASAEIQLAVGHAPQLT------ELPRDVTVELGRSALLACRATGRPP 814
Query: 167 VRYSWRRGQEV---LLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNV 223
+WRRG L G+ +G +P ++ +L +++ P+D A Y C A
Sbjct: 815 PTVTWRRGDGQPLGLRLGAGRGSRSRQP-----DSGVLFFESVAPEDQAPYVCEAR---- 865
Query: 224 CNIPDKMVSFRLSNKTASPSIKLLVDDPIV-VNPGEAITLVCVTTGGEPAPSLTWVRSFG 282
N+ K+ + T ++ P V V G+ ++L C+ G P P W++
Sbjct: 866 -NVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGR 924
Query: 283 TLP---EKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWIT 339
LP ++ G+L + + AG YSC+A N G+ + ++V+ + I
Sbjct: 925 PLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGS-QHRDVELVVQVPPR----IH 979
Query: 340 PDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLR------------------ 381
P H N G + C VP+ +T++ N R
Sbjct: 980 PTATHHITN--EGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPS 1037
Query: 382 -----------------SSERMVITQTDPDVSP---------GTTNLDIIDLKFTDFGTY 415
SS+ M ++ +S + +L + ++ D G Y
Sbjct: 1038 AQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHY 1097
Query: 416 TCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTR--EGDTIELQCQVTGKPKP 473
C AS G S + VPP + + P V + G+ ++L C G P+P
Sbjct: 1098 ECTASNPAGSAS----HRYVLGVQVPPQV----QPGPRVLKVLVGEALDLNCVAEGNPEP 1149
Query: 474 IILWSRADKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALV 532
+ WS+ DG +Q G++ + +G YRC+ S G + E V
Sbjct: 1150 QLSWSK--------DGVVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRV 1201
Query: 533 QLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLG---NKLLRTGQFD 589
+ LE G++ S+ R P +T WR G L
Sbjct: 1202 LEPPHWGADETSGLLERVAGENASLPCPA---RGTPKPQVT--WRKGPSSEPLHGQPGVA 1256
Query: 590 SQEYTEYAVKSLSNENYGVYNCSIINEAGA 619
E + S+S + G Y C NE G+
Sbjct: 1257 VLEEGSLFLASVSPADSGDYECQATNEVGS 1286
Score = 92.8 bits (229), Expect = 1e-18
Identities = 135/605 (22%), Positives = 229/605 (37%), Gaps = 74/605 (12%)
Query: 47 ERVYTIREGETLELTCLVTGHPRPQIRWTKTAGS-ASDRFQDSSVFNETLRITNIQRHQG 105
E V + +G+T L C VTGHP+P++ W K A S L++
Sbjct: 2452 EEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSA 2511
Query: 106 GRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNP 165
G Y C A N +G K ++ V L ++ + + + + L C A + P
Sbjct: 2512 GHYSCIAANAVGEKT-KHFQLSV-LLAPTILGGAEDSADEEVTVTVNNPISLICEALAFP 2569
Query: 166 PVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCN 225
+W + + + +++ T L++ N + +D Y+C+ V N
Sbjct: 2570 SPNITWMKDGAPF--EASRNIQLLP------GTHGLQILNAQKEDAGQYTCV-----VTN 2616
Query: 226 IPDKMVSFRLSNKTASPSIKLLVDDP--------IVVNPGEAITLVCVTTGGEPAPSLTW 277
+ V PSI DDP + +TL C + P P++ W
Sbjct: 2617 ELGEAVKNYHVEVLIPPSIS--KDDPLGEVGVKEVKTKVNSTLTLEC-ESWAVPPPTIRW 2673
Query: 278 VRSFGTLPEKTVL----NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRA--- 330
+ + + L G L I D+G Y C+A N G + N++++
Sbjct: 2674 YKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGED-DQDFNVLIQVPPM 2732
Query: 331 -LKKGRFWITPDPYHKDDNIQIG----REV------KISCQVEAVPSEELTFSWFKNGRP 379
K G F + +++ + G RE+ + C A+P +LT W++ +P
Sbjct: 2733 FQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLT--WYREDQP 2790
Query: 380 LRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSST 439
L + + + + Q G L I ++ + G Y+C AS + + + + T
Sbjct: 2791 LSAGDEVSVLQ-------GGRVLQIPLVRAENAGRYSCKAS---NEVGEDWLHYELLVLT 2840
Query: 440 VPPNLTVPQEKSPLVT-REGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDG 498
P L +E VT T+ LQC G P P I W + + P +Q+
Sbjct: 2841 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS-PSPRLQVLEDGQ 2899
Query: 499 TLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLE-IRQGQDRSV 557
L++ + Y C G E L L VQ PP + LE + + SV
Sbjct: 2900 VLQVSTAEVADAASYMCVAENQAG----SAEKLFTLRVQVPPRIAGLDLEQVTAILNSSV 2955
Query: 558 TMSCRVLRAYPIRVLTYEWRLGNKLLRTGQ----FDSQEYTEYAVKSLSNENYGVYNCSI 613
++ C V A+P +T W ++ L G+ + LS+ G+Y C
Sbjct: 2956 SLPCDV-HAHPNPEVT--WYKDSQALSLGEEVFLLPGTHTLQLGRARLSDS--GMYTCEA 3010
Query: 614 INEAG 618
+N AG
Sbjct: 3011 LNAAG 3015
Score = 89.4 bits (220), Expect = 1e-17
Identities = 142/663 (21%), Positives = 229/663 (34%), Gaps = 142/663 (21%)
Query: 48 RVYTIREGETLELTCLVTGHPRPQIRWTKTAGS-----------ASDRFQDSSVFNETLR 96
R T+ G + L C TG P P + W + G + R DS V L
Sbjct: 793 RDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV----LF 848
Query: 97 ITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVF 156
++ Y C+A N G ++ + + + + ++ + Q V
Sbjct: 849 FESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQ-----PVS 903
Query: 157 LRCVANSNPPV-RYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYS 215
L C+ + P+ W + L GS + G L L + YS
Sbjct: 904 LPCIVLAGRPLPERHWLKDGRPLPPGSRHSIR------ADGS---LHLDRALQEHAGRYS 954
Query: 216 CIAS---------VRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVT 266
C+A+ V V +P ++ + TA+ I N G +L CV
Sbjct: 955 CVATNTAGSQHRDVELVVQVPPRI------HPTATHHI---------TNEGVPASLPCVA 999
Query: 267 TGGEPAPSLTWVRSFGTL----PEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKK 322
+G PAP++TW + L P V GTL I ++ DAG Y C A N VG +++
Sbjct: 1000 SG-VPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQE 1058
Query: 323 STNIIVRALKKGRFW----ITPDPYHKDDNIQIGREVKISC------------------- 359
+ R W + P + +Q+G C
Sbjct: 1059 MRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQV 1118
Query: 360 --QVEAVP-------SEELTFSWFKNGRPLR----SSERMVITQTDPDVSPGTTNLDIID 406
QV+ P E L + G P S + +V+ P S +
Sbjct: 1119 PPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGS-----VHFAA 1173
Query: 407 LKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQ 466
++ +D G Y C AS G+ +++ + PP+ + L G+ L C
Sbjct: 1174 IRTSDAGRYRCEAS-NSAGVDAWEVELRVLE---PPHWGADETSGLLERVAGENASLPCP 1229
Query: 467 VTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVK 526
G PKP + W + + +G+L + +VS SG Y CQ + G +
Sbjct: 1230 ARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSR 1289
Query: 527 PREALVQLIVQYPPAVEP----AFLEIRQGQDRSVTMSCRV---------------LRAY 567
+L+V PP++ A + GQ S+T+ C L
Sbjct: 1290 R----AKLVVYVPPSIREDGRKANVSGMAGQ--SLTLECDANGFPVPEIVWLKDAQLVGV 1343
Query: 568 PIRVLTYEWRLG------NKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGR 621
P+ Y W LG ++LL GQ + + G+Y+C N+AG +
Sbjct: 1344 PLGWAGYGWDLGWGQVGGHRLLDEGQ-------SLHFPRIQEGDSGLYSCRAENQAGTAQ 1396
Query: 622 CSF 624
F
Sbjct: 1397 RDF 1399
Score = 82.4 bits (202), Expect = 2e-15
Identities = 132/580 (22%), Positives = 218/580 (37%), Gaps = 63/580 (10%)
Query: 56 ETLELTCLVTGHPRPQIRWTKTAGSASDR-FQDSSVFNETLRITNIQRHQGGRYYCKAEN 114
E++ L C P P + W K R S L++ G Y C+A N
Sbjct: 2086 ESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALN 2145
Query: 115 GLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRG 174
G K ++V+ PV + +S + + L C P + SWR+
Sbjct: 2146 QAGHSE-KHYNLNVWVA--PVFPLRESHTLTVREGH---PTSLSCECRGVPFPKISWRKD 2199
Query: 175 QEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFR 234
+ L G G++ ++L L + Y+C S + D +
Sbjct: 2200 GQPL-PGEGAGLQ-----HVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVH 2253
Query: 235 LSNKTASPSIKLLVDDPI---VVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN 291
+ + A P + P VV G A TL C TG +P P++TW R + + L
Sbjct: 2254 VPPQIAGPR-----EPPTQVSVVQDGVA-TLECNATG-KPPPTVTWERDGQPVGAELGLQ 2306
Query: 292 ----GGTLTIPAITSDDAGTYSCIANNNVGNPAKK-STNIIVRALKKGRFWITPDPYHKD 346
G +L + + G YSC+A N G +K +++V G DP
Sbjct: 2307 LQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDL----DPL--- 2359
Query: 347 DNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 406
NI ++ EA+ WF+ P+ E D + G L +
Sbjct: 2360 TNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGE-------DTYLLAGGWMLKMTQ 2412
Query: 407 LKFTDFGTYTCVASLKGGGIS-DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQC 465
+ D G Y+C+AS + G + S++V VPP++ + + +G T L C
Sbjct: 2413 TQEQDSGLYSCLASNEAGEARRNFSVEV-----LVPPSIENEDLEEVIKVLDGQTAHLMC 2467
Query: 466 QVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT-LRIVNVSREMSGMYRCQTSQYNGFN 524
VTG P+P + W + + +A G S DG L+++ + +G Y C + G
Sbjct: 2468 NVTGHPQPKLTWFKDGRPLAR--GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEK 2525
Query: 525 VKPREALVQLIVQYPPAV-----EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLG 579
K QL V P + + A E+ + +++ C L A+P +T+ + G
Sbjct: 2526 TKH----FQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEAL-AFPSPNITW-MKDG 2579
Query: 580 NKLLRTGQFDSQEYTE-YAVKSLSNENYGVYNCSIINEAG 618
+ T + + E+ G Y C + NE G
Sbjct: 2580 APFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 2619
Score = 77.0 bits (188), Expect = 8e-14
Identities = 124/579 (21%), Positives = 211/579 (36%), Gaps = 68/579 (11%)
Query: 58 LELTCLVTGHPRPQIRWTKTAGSASDRFQDS-SVF--NETLRITNIQRHQGGRYYCKAEN 114
+ LTC TG P P + W K S VF L + + + GRY C A +
Sbjct: 1995 VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVS 2054
Query: 115 GLGSPAIKSIRVDVYYLDDPVVTVHQSIG----EAKEQFYYERTVFLRCVANSNPPVRYS 170
+G D V+ VH E +V L C +++ PP S
Sbjct: 2055 AVGEDR-----------QDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 2103
Query: 171 WRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKM 230
W + + +E + +L++ D +Y+C A N +K
Sbjct: 2104 WWK--------DGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEA--LNQAGHSEKH 2153
Query: 231 VSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP----- 285
+ N +P L + V G +L C G P P ++W + LP
Sbjct: 2154 YNL---NVWVAPVFPLRESHTLTVREGHPTSLSC-ECRGVPFPKISWRKDGQPLPGEGAG 2209
Query: 286 -EKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH 344
+ G L + GTY+C +N VGN + + + V + P
Sbjct: 2210 LQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGN-SSQDLQLEVHVPPQ-----IAGPRE 2263
Query: 345 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDI 404
+ + ++ + + A T +W ++G+P+ + + + +L +
Sbjct: 2264 PPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQG-------QSLHV 2316
Query: 405 IDLKFTDFGTYTCVA-SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTRE-GDTIE 462
+ G Y+CVA +L G + V VPP L + +T +
Sbjct: 2317 ERAQAAHTGRYSCVAENLAGRAERKFELSV-----LVPPELIGDLDPLTNITAALHSPLT 2371
Query: 463 LQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNG 522
L C+ G P P I W R ++ V+ P + + L++ + SG+Y C S N
Sbjct: 2372 LLCEAMGIPPPAIRWFRGEEPVS-PGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS--NE 2428
Query: 523 FNVKPREALVQLIVQYPPAVEPAFLE--IRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGN 580
R V+++V PP++E LE I+ ++ + C V +P LT+ ++ G
Sbjct: 2429 AGEARRNFSVEVLV--PPSIENEDLEEVIKVLDGQTAHLMCNV-TGHPQPKLTW-FKDGR 2484
Query: 581 KLLR-TGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAG 618
L R S + V + + G Y+C N G
Sbjct: 2485 PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVG 2523
Score = 74.3 bits (181), Expect = 5e-13
Identities = 74/289 (25%), Positives = 124/289 (42%), Gaps = 31/289 (10%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYC 110
++R G+ L L C G P P+I WT ++ + TL+ + R G Y C
Sbjct: 4139 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDG-GSTLQRAAVSREDSGTYVC 4197
Query: 111 KAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYE--RTVFLRCVANSNPPVR 168
AEN +G S V+ + PV+ GEA ++ L CV +P
Sbjct: 4198 WAENRVGRTQAVSF---VHVKEAPVLQ-----GEAFSYLVEPVGGSIQLDCVVRGDPVPD 4249
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
W + + L+GS ++ T T+ D Y C+A N +
Sbjct: 4250 IHWIK-DGLPLRGSHLRHQLQNGSLTIHRTE--------RDDAGRYQCLAE--NEMGVAK 4298
Query: 229 KMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT 288
K+V L + +P ++ D + V G+ + L C TG EP P++ W+++ L
Sbjct: 4299 KVVILVLQS---APVFQVEPQD-MTVRSGDDVALRCQATG-EPTPTIEWLQAGQPLRASR 4353
Query: 289 ---VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKG 334
L G+L + + + DAGTY C+A+N +G+ ++ ++VR +G
Sbjct: 4354 RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAF-LVVRGEPQG 4401
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 125 bits (313), Expect = 2e-28
Identities = 156/586 (26%), Positives = 246/586 (41%), Gaps = 71/586 (12%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF-NETLRITNIQRHQGGRYYCKAE 113
G L LTC V+G P P + W K V L+++ +Q Q G Y C AE
Sbjct: 1857 GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAE 1916
Query: 114 NGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYE-RTVFLRCVANSNPPVRYSWR 172
N + A K V V V +S G A+E E + V L C A+ PP +W
Sbjct: 1917 N-TQAEARKDFVVAVL-----VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWL 1970
Query: 173 RGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVS 232
+ L G D G + F+ G + L LK LR D Y+C+A N +
Sbjct: 1971 KDGSPL--GQDMGPHL--RFYLDGGS--LVLKGLRASDAGAYTCVAH-----NPAGEDAR 2019
Query: 233 FRLSNKTASPSIKLLVD--DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP--EKT 288
N P+IK D +V PGE +T+VC G P ++W++ LP ++T
Sbjct: 2020 LHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPI-HVSWLKDGLPLPLSQRT 2078
Query: 289 VLNGG--TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKD 346
+L+G TL I + DAG ++C+A + G A ++ + V+ + P + D
Sbjct: 2079 LLHGSGHTLRISKVQLADAGIFTCVAASPAG-VADRNFTLQVQVPPV----LEPVEFQND 2133
Query: 347 DNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 406
+ G V++ C+ VP SW K+G PL S + P +L +
Sbjct: 2134 VVVVRGSLVELPCEARGVPLP--LVSWMKDGEPLLSQS----LEQGP-------SLQLEA 2180
Query: 407 LKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQ 466
+ D GTY+CVA + G + + + PP++ + + L G +EL C
Sbjct: 2181 VGAGDSGTYSCVA-VSEAGEARRHFQLTVME---PPHIEDSGQPTELSLTPGAPMELLCD 2236
Query: 467 VTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVK 526
G P+P I W + + + ++E+ R++ V +G+Y C G
Sbjct: 2237 AQGTPQPNITWHKDGQALT------RLENNSRATRVLRV--RDAGLYTCLAESPAG---- 2284
Query: 527 PREALVQLIVQYPPAV----EPAF-LEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNK 581
E ++ VQ PP + P F + + GQ + + C V A P +T+ R G
Sbjct: 2285 AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQ---LVLECSV-EAEPAPKITWH-RDGIV 2339
Query: 582 LLRTGQFDSQEYTEY-AVKSLSNENYGVYNCSIINEAGAGRCSFLV 626
L E + +++LS + G Y+C+ N AG+ +F V
Sbjct: 2340 LQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRV 2385
Score = 119 bits (299), Expect = 1e-26
Identities = 144/592 (24%), Positives = 237/592 (40%), Gaps = 67/592 (11%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDS-SVFNETLRITNIQRHQGGRYYC 110
+ E ++ L CL +G P P + W K S + SV LRI Q G Y C
Sbjct: 615 VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRC 674
Query: 111 KAENGLGSPAIK-SIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRY 169
A N GS ++ +RV+V P +T+ S+ V L C A P
Sbjct: 675 VASNVAGSTELRYGLRVNV----PPRITLPPSL---PGPVLVNTPVRLTCNATGAPSPTL 727
Query: 170 SWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDK 229
W + + G++++ ++L L + R D YSC+A + D
Sbjct: 728 MWLKDGNPVSPAGTPGLQVFP------GGRVLTLASARASDSGRYSCVAVSAVGEDRQDV 781
Query: 230 MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV 289
++ + PSI L + + V E++ L C + P P L+W + L +
Sbjct: 782 VLQVHM-----PPSI-LGEELNVSVVANESVALEC-QSHAMPPPVLSWWKDGRPLEPRPG 834
Query: 290 L----NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITP-DPYH 344
+ + L + DAG Y+C A N G+ ++K N+ V W+ P P
Sbjct: 835 VHLSADKALLQVDRADVWDAGHYTCEALNQAGH-SEKHYNLNV--------WVAPVFPLR 885
Query: 345 KDDNIQI--GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNL 402
+ + + G ++SC+ VP ++ SW K+G+PL + VS L
Sbjct: 886 ESHTLTVREGHPTRLSCECRGVPFPKI--SWRKDGQPLPGEGAGL-----QHVSAVGRLL 938
Query: 403 DIIDLKFTDFGTYTCVAS-LKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTI 461
+ + GTYTC S + G D+ ++V+ VPP + P+E V+ D +
Sbjct: 939 YLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVH-----VPPQIAGPREPPTQVSVVQDGV 993
Query: 462 -ELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQY 520
L+C TGKP P + W R + V G +Q+++ +L + +G Y C
Sbjct: 994 ATLECNATGKPPPTVTWERDGQPVGAELG-LQLQNQGQSLHVERAQAAHTGRYSCVAENL 1052
Query: 521 NGFNVKPREALVQLIVQYPPA----VEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEW 576
G E +L V PP ++P I +T+ C + P + W
Sbjct: 1053 AG----RAERKFELSVLVPPELIGDLDP-LTNITAALHSPLTLLCEAMGIPPPAI---RW 1104
Query: 577 RLGNKLLRTGQFDSQEYTEYAVK--SLSNENYGVYNCSIINEAGAGRCSFLV 626
G + + G+ + +K ++ G+Y+C NEAG R +F V
Sbjct: 1105 FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSV 1156
Score = 117 bits (293), Expect = 5e-26
Identities = 153/624 (24%), Positives = 253/624 (40%), Gaps = 87/624 (13%)
Query: 43 ERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNET--LRITNI 100
E ++ T+ + L C P P I W K G+ + ++ + T L+I N
Sbjct: 1262 EDSADEEVTVTVNNPISLICEALAFPSPNITWMKD-GAPFEASRNIQLLPGTHGLQILNA 1320
Query: 101 QRHQGGRYYCKAENGLGSPAIKSIRVDVYY-----LDDPVVTVHQSIGEAKEQFYYERTV 155
Q+ G+Y C N LG A+K+ V+V DDP+ V + E K + T+
Sbjct: 1321 QKEDAGQYTCVVTNELGE-AVKNYHVEVLIPPSISKDDPLAEV--GVKEVKTK--VNSTL 1375
Query: 156 FLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYS 215
L C + + PP W + + + S V GE ++L+++ + D Y
Sbjct: 1376 TLECESWAVPPPTIRWYKDGQPVTPSSRLQV--------LGEGRLLQIQPTQVSDSGRYL 1427
Query: 216 CIASVRNVC------------------NIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPG 257
C+A+ NV + D +F + ++ + IV N
Sbjct: 1428 CVAT--NVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVEN-- 1483
Query: 258 EAITLVCVTTGGEPAPSLTWVRSFGTL---PEKTVLNGG-TLTIPAITSDDAGTYSCIAN 313
L C T P P LTW R L E +VL GG L IP + +++AG YSC A+
Sbjct: 1484 NPAYLYC-DTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS 1542
Query: 314 NNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSW 373
N VG +++ I D + + + +S Q A+ + T SW
Sbjct: 1543 NEVGEDWLHYELLVLTPPV-----ILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW 1597
Query: 374 FKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDI-SID 432
+NG P S R+ + + D V L + + D +Y CVA + G + ++
Sbjct: 1598 LQNGLPFSPSPRLQVLE-DGQV------LQVSTAEVADAASYMCVAENQAGSAEKLFTLR 1650
Query: 433 VNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQ 492
V VPP + + + ++ L C V P P + W + + +++ +
Sbjct: 1651 VQ-----VPPRI-AGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFL 1704
Query: 493 MESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPA------F 546
+ TL++ SGMY C+ G + K LVQL V PPA A
Sbjct: 1705 LPG-THTLQLGRARLSDSGMYTCEALNAAGRDQK----LVQLSVLVPPAFRQAPRGPQDA 1759
Query: 547 LEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL---RTGQFDSQEYTEYAVKSLSN 603
+ +R G D++V +SC A P +T+ ++ G L+ RT + E +S+
Sbjct: 1760 VLVRVG-DKAV-LSCET-DALPEPTVTW-YKDGQPLVLAQRTQALRGGQRLEIQEAQVSD 1815
Query: 604 ENYGVYNCSIINEAGAGRCSFLVT 627
+ G+Y+C + N AG +F +T
Sbjct: 1816 K--GLYSCKVSNVAGEAVRTFTLT 1837
Score = 116 bits (291), Expect = 9e-26
Identities = 145/596 (24%), Positives = 238/596 (39%), Gaps = 86/596 (14%)
Query: 50 YTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF-NETLRITNIQRHQGGRY 108
+T+ + LTC TG P P + W+K R V + L I GRY
Sbjct: 2584 FTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRY 2643
Query: 109 YCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
C A N G + V + PVV S+ A E V L C A+ P
Sbjct: 2644 TCSARNSAG---VAHKHVFLTVQASPVVKPLPSVVRA----VAEEEVLLPCEASGIPRPT 2696
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
+W++ +G + + G+ L++ + P+D NY CIA
Sbjct: 2697 ITWQK------EGLNVATGVSTQVLPGGQ---LRIAHASPEDAGNYLCIA---------- 2737
Query: 229 KMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTG----------GEPAPSLTWV 278
+ S +A +L+V P V+ G + + T G G P P++TW
Sbjct: 2738 -----KNSAGSAMGKTRLVVQVPPVIENG--LPDLSTTEGSHAFLPCKARGSPEPNITWD 2790
Query: 279 RS----FGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKG 334
+ G + T+ G L + + DAGTY+C A N VG A++ ++ + L
Sbjct: 2791 KDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR-ARRRVHLTILVLPV- 2848
Query: 335 RFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPD 394
F P D ++++G + + C P+ + W N RP+ +++ D
Sbjct: 2849 -FTTLPG----DRSLRLGDRLWLRCAARGSPTPRI--GWTVNDRPVTEG----VSEQD-- 2895
Query: 395 VSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLV 454
G + L + D GTY C A + G +S V++ + V + S LV
Sbjct: 2896 ---GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF-VHVKEAPVLQG----EAFSYLV 2947
Query: 455 TREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYR 514
G +I+L C V G P P I W + + + ++ + +G+L I R+ +G Y+
Sbjct: 2948 EPVGGSIQLDCVVRGDPVPDIHWIK--DGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQ 3005
Query: 515 CQTSQYNGFNVKPREALVQLIVQYPPA--VEPAFLEIRQGQDRSVTMSCRVLRAYPIRVL 572
C G K +V L++Q P VEP + +R G D V + C +A
Sbjct: 3006 CLAENEMGVAKK----VVILVLQSAPVFQVEPQDMTVRSGDD--VALRC---QATGEPTP 3056
Query: 573 TYEW-RLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRC-SFLV 626
T EW + G L + + + ++++ + G Y+C N G+ +FLV
Sbjct: 3057 TIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLV 3112
Score = 113 bits (282), Expect = 1e-24
Identities = 149/583 (25%), Positives = 220/583 (37%), Gaps = 123/583 (21%)
Query: 16 EGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWT 75
E + G PP++R G N+ G++L L C G P P+I W
Sbjct: 6 EPLLNTGSVVPPSIR--EDGRKANVSG----------MAGQSLTLECDANGFPVPEIVWL 53
Query: 76 KTA----------GSASD---------RFQDSSVFNETLRITNIQRHQGGRYYCKAENGL 116
K A G D R D ++L IQ G Y C+AEN
Sbjct: 54 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEG---QSLHFPRIQEGDSGLYSCRAENQA 110
Query: 117 GSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERT---VFLRCVANSNPPVRYSWRR 173
G+ + D + L V+T +G Q V L+C + P + W +
Sbjct: 111 GTA-----QRDFHLL---VLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK 162
Query: 174 GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSF 233
++ +L G Q + ++L++ D Y C+A D +
Sbjct: 163 DRQPVLPGGPH-------LQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV 215
Query: 234 RL------SNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK 287
SN+T + V + L+C G P P++TW + LP
Sbjct: 216 HAPPTIWGSNETGE----------VAVMEDHLVQLLCEARG-VPTPNITWFKDGALLPTS 264
Query: 288 TVL----NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKK-----GRFWI 338
T + G L + S DAG Y+C A+N VG A+K+T + V GR ++
Sbjct: 265 TKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG-AAEKATRLDVYVPPTIEGAGGRPYV 323
Query: 339 TPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDV--- 395
GR V + C PS T SW G P+ S + +TD V
Sbjct: 324 V--------KAVAGRPVALECVARGHPSP--TLSWHHEGLPVAESNESRL-ETDGSVLRL 372
Query: 396 -SPGTTNLDIIDLKFTDFGTYTCVASLKGG-GISDISIDVNISSSTVPPNLTVPQEKSPL 453
SPG + G Y+CVAS G + S++V VPP L V + +
Sbjct: 373 ESPGEASS----------GLYSCVASSPAGEAVLQYSVEVQ-----VPPQLLVAEGLGQV 417
Query: 454 VTREGDTIELQCQVTGKPKPIILW---SRADKEVAMPDGSMQMESYDGTLRIVNVSREMS 510
T G +EL CQ +G P P I W R +E+A +Q+ S TL I +V + S
Sbjct: 418 TTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELA----GVQVASQGTTLHIDHVELDHS 473
Query: 511 GMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQ 553
G++ CQ + N E V + ++ P V LE+ GQ
Sbjct: 474 GLFACQAT--NEAGTAGAEVEVSVHGEWAPGV----LEVPIGQ 510
Score = 112 bits (280), Expect = 2e-24
Identities = 132/550 (24%), Positives = 221/550 (40%), Gaps = 72/550 (13%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSASDR---FQDSSVFNETLRITNIQRHQGGR 107
T+REG L+C G P P+I W K Q S L + Q Q G
Sbjct: 891 TVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 950
Query: 108 YYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPV 167
Y C+ N +G+ + + ++++V+ P + + L C A PP
Sbjct: 951 YTCECSNVVGNSS-QDLQLEVHV---PPQIAGPREPPTQVSVVQDGVATLECNATGKPPP 1006
Query: 168 RYSWRR-GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNI 226
+W R GQ V G++ G+++ Q + + L ++ + YSC+A N+
Sbjct: 1007 TVTWERDGQPV---GAELGLQL------QNQGQSLHVERAQAAHTGRYSCVA--ENLAGR 1055
Query: 227 PDKMVSFRLSNKTASPSIKLLVDDP---IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGT 283
++ F LS I L DP I +TL+C G P P++ W R G
Sbjct: 1056 AER--KFELSVLVPPELIGDL--DPLTNITAALHSPLTLLCEAM-GIPPPAIRWFR--GE 1108
Query: 284 LP----EKTVL--NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFW 337
P E T L G L + D+G YSC+A+N G A+++ ++ V
Sbjct: 1109 EPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGE-ARRNFSVEV--------- 1158
Query: 338 ITPDPYHKDDNIQI-----GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTD 392
+ P +D ++ G+ + C V P +LT WFK+GRPL +
Sbjct: 1159 LVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLT--WFKDGRPLARGDA------- 1209
Query: 393 PDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKS- 451
+SP L ++ + G Y+C+A+ + + + +S P L ++ +
Sbjct: 1210 HHISPDGVLLQVLQANLSSAGHYSCIAA---NAVGEKTKHFQLSVLLAPTILGGAEDSAD 1266
Query: 452 -PLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT--LRIVNVSRE 508
+ + I L C+ P P I W K+ A + S ++ GT L+I+N +E
Sbjct: 1267 EEVTVTVNNPISLICEALAFPSPNITWM---KDGAPFEASRNIQLLPGTHGLQILNAQKE 1323
Query: 509 MSGMYRCQTSQYNGFNVKPREALVQL---IVQYPPAVEPAFLEIRQGQDRSVTMSCRVLR 565
+G Y C + G VK V + I + P E E++ + ++T+ C
Sbjct: 1324 DAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWA 1383
Query: 566 AYPIRVLTYE 575
P + Y+
Sbjct: 1384 VPPPTIRWYK 1393
Score = 111 bits (277), Expect = 4e-24
Identities = 146/599 (24%), Positives = 234/599 (39%), Gaps = 84/599 (14%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF--NETLRITNIQRHQGGRYY 109
+R G+ L+C P P + W K G Q + + L I Q G Y
Sbjct: 1762 VRVGDKAVLSCETDALPEPTVTWYKD-GQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYS 1820
Query: 110 CKAENGLGSPA---IKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPP 166
CK N G +++V + + TV Q G + L C + P
Sbjct: 1821 CKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGS---------PLVLTCDVSGVPA 1871
Query: 167 VRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNI 226
+W + + + + GV ++G L+L L+P Y+C+A
Sbjct: 1872 PTVTWLKDRMPVESSAVHGV------VSRGGR--LQLSRLQPAQAGTYTCVAENTQAEAR 1923
Query: 227 PDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPE 286
D +V+ ++ + S V V G+ + L C G+P P + W++ L +
Sbjct: 1924 KDFVVAVLVAPRIRSSG----VAREHHVLEGQEVRLDC-EADGQPPPDVAWLKDGSPLGQ 1978
Query: 287 ------KTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKST-NIIVRALKK----GR 335
+ L+GG+L + + + DAG Y+C+A+N G A+ T N++V K G
Sbjct: 1979 DMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGS 2038
Query: 336 FWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDV 395
+ P G V + C V P + SW K+G PL S+R ++
Sbjct: 2039 GTLVSRP---------GELVTMVCPVRGSP--PIHVSWLKDGLPLPLSQRTLLH------ 2081
Query: 396 SPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVT 455
G T L I ++ D G +TCVA+ G++D + + + VPP L + ++ +V
Sbjct: 2082 GSGHT-LRISKVQLADAGIFTCVAA-SPAGVADRNFTLQVQ---VPPVLEPVEFQNDVVV 2136
Query: 456 REGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRC 515
G +EL C+ G P P++ W + D E + Q S L++ V SG Y C
Sbjct: 2137 VRGSLVELPCEARGVPLPLVSWMK-DGEPLLSQSLEQGPS----LQLEAVGAGDSGTYSC 2191
Query: 516 QTSQYNGFNVKPREALVQLIVQYPPAVE----PAFLEIRQGQDRSVTMSCRVLRAYPIRV 571
G QL V PP +E P L + G + + P
Sbjct: 2192 VAVSEAG----EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDA---QGTPQPN 2244
Query: 572 LTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKA 630
+T+ + G L R E A + L + G+Y C + AGA SF V +A
Sbjct: 2245 ITWH-KDGQALTRL------ENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQA 2296
Score = 110 bits (276), Expect = 5e-24
Identities = 135/592 (22%), Positives = 244/592 (41%), Gaps = 77/592 (13%)
Query: 57 TLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF----NETLRITNIQRHQGGRYYCKA 112
++ L C V HP P++ W K + + S VF TL++ + G Y C+A
Sbjct: 1672 SVSLPCDVHAHPNPEVTWYKDSQALS---LGEEVFLLPGTHTLQLGRARLSDSGMYTCEA 1728
Query: 113 ENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERT---VFLRCVANSNPPVRY 169
N G K +++ V V + + R L C ++ P
Sbjct: 1729 LNAAGRDQ-KLVQLSVL-----VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTV 1782
Query: 170 SWRR-GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
+W + GQ ++L + + +G + L+++ + D YSC V N+
Sbjct: 1783 TWYKDGQPLVLAQRTQAL--------RGGQR-LEIQEAQVSDKGLYSC-----KVSNVAG 1828
Query: 229 KMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT 288
+ V P+ + + + G + L C G PAP++TW++ +
Sbjct: 1829 EAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTC-DVSGVPAPTVTWLKDRMPVESSA 1887
Query: 289 V----LNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH 344
V GG L + + AGTY+C+A N A+ + +V L R I
Sbjct: 1888 VHGVVSRGGRLQLSRLQPAQAGTYTCVAEN---TQAEARKDFVVAVLVAPR--IRSSGVA 1942
Query: 345 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTT---- 400
++ ++ G+EV++ C+ + P ++ +W K+G PL D+ P
Sbjct: 1943 REHHVLEGQEVRLDCEADGQPPPDV--AWLKDGSPL-----------GQDMGPHLRFYLD 1989
Query: 401 --NLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKS-PLVTRE 457
+L + L+ +D G YTCVA G + + VN+ VPP + + S LV+R
Sbjct: 1990 GGSLVLKGLRASDAGAYTCVAHNPAGEDARLH-TVNV---LVPPTIKQGADGSGTLVSRP 2045
Query: 458 GDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQT 517
G+ + + C V G P + W + + + ++ + TLRI V +G++ C
Sbjct: 2046 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTL-LHGSGHTLRISKVQLADAGIFTCVA 2104
Query: 518 SQYNGFNVKPREALVQLIVQYPPAVEPAFL--EIRQGQDRSVTMSCRVLRAYPIRVLTYE 575
+ G V R +Q VQ PP +EP ++ + V + C R P+ ++++
Sbjct: 2105 ASPAG--VADRNFTLQ--VQVPPVLEPVEFQNDVVVVRGSLVELPCEA-RGVPLPLVSW- 2158
Query: 576 WRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 627
+ G LL ++ ++++ + G Y+C ++EAG R F +T
Sbjct: 2159 MKDGEPLLSQ---SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 2207
Score = 108 bits (270), Expect = 2e-23
Identities = 136/552 (24%), Positives = 225/552 (40%), Gaps = 81/552 (14%)
Query: 95 LRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERT 154
L+I + G Y C A N L + + + + V +V + G + +
Sbjct: 568 LQIEKVDLRDEGIYTCAATN-LAGESKREVALKV------LVPPNIEPGPVNKAVLENAS 620
Query: 155 VFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANY 214
V L C+A+ PP SW +G + + V + + ++L+++ + D +Y
Sbjct: 621 VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSV--------DGRVLRIEQAQLSDAGSY 672
Query: 215 SCIASVRNVCNIPDKMVSFRLSNKTASPSIKL--LVDDPIVVNPGEAITLVCVTTGGEPA 272
C+AS NV + R++ P I L + P++VN + L C TG P+
Sbjct: 673 RCVAS--NVAGSTELRYGLRVN---VPPRITLPPSLPGPVLVNT--PVRLTCNATGA-PS 724
Query: 273 PSLTWVRSFGTL-----PEKTVLNGG-TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNI 326
P+L W++ + P V GG LT+ + + D+G YSC+A + VG + ++
Sbjct: 725 PTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQ---DV 781
Query: 327 IVRALKKGRFWITPDPYHKDDNIQI--GREVKISCQVEAVPSEELTFSWFKNGRPLRSSE 384
+++ + P ++ N+ + V + CQ A+P L SW+K+GRPL
Sbjct: 782 VLQV------HMPPSILGEELNVSVVANESVALECQSHAMPPPVL--SWWKDGRPLE--- 830
Query: 385 RMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNL 444
+ +S L + D G YTC A L G S+ ++N+ + V P
Sbjct: 831 ----PRPGVHLSADKALLQVDRADVWDAGHYTCEA-LNQAGHSEKHYNLNVWVAPVFP-- 883
Query: 445 TVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVN 504
+E L REG L C+ G P P I W + + + +Q S G L +
Sbjct: 884 --LRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLG 941
Query: 505 VSR-EMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV----EPAFLEIRQGQDRSVTM 559
++ G Y C+ S G + + +QL V PP + EP ++ QD T+
Sbjct: 942 QAQLAQEGTYTCECSNVVGNSSQD----LQLEVHVPPQIAGPREPP-TQVSVVQDGVATL 996
Query: 560 SCRVLRAYPIRVLTYE-------WRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCS 612
C P +T+E LG +L GQ E + A + G Y+C
Sbjct: 997 ECNA-TGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAA-------HTGRYSCV 1048
Query: 613 IINEAGAGRCSF 624
N AG F
Sbjct: 1049 AENLAGRAERKF 1060
Score = 108 bits (270), Expect = 2e-23
Identities = 134/598 (22%), Positives = 230/598 (38%), Gaps = 93/598 (15%)
Query: 48 RVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF---NETLRITNIQRHQ 104
R + + EG+ + L C G P P + W K F +L + ++
Sbjct: 1943 REHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASD 2002
Query: 105 GGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSN 164
G Y C A N PA + R+ + P + G V + C +
Sbjct: 2003 AGAYTCVAHN----PAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGS 2058
Query: 165 PPVRYSWRR-------GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCI 217
PP+ SW + Q LL GS G T L++ ++ D ++C+
Sbjct: 2059 PPIHVSWLKDGLPLPLSQRTLLHGS-------------GHT--LRISKVQLADAGIFTCV 2103
Query: 218 ASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTW 277
A+ + + D+ + ++ ++ D +VV G + L C G P P ++W
Sbjct: 2104 AA--SPAGVADRNFTLQVQVPPVLEPVEFQND--VVVVRGSLVELPCEARG-VPLPLVSW 2158
Query: 278 VRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFW 337
++ L +++ G +L + A+ + D+GTYSC+A + G A++ + V
Sbjct: 2159 MKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGE-ARRHFQLTVM-------- 2209
Query: 338 ITPDPYHKDD-------NIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQ 390
+P H +D ++ G +++ C + P +T W K+G+ L E
Sbjct: 2210 ---EPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT--WHKDGQALTRLEN----- 2259
Query: 391 TDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEK 450
+ T + L+ D G YTC+A G I + S V + + PPN+ P+
Sbjct: 2260 -----NSRATRV----LRVRDAGLYTCLAESPAGAI-EKSFRVRVQA---PPNIVGPRGP 2306
Query: 451 SPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMS 510
+V + L+C V +P P I W R D V D Q L++ +S S
Sbjct: 2307 RFVVGLAPGQLVLECSVEAEPAPKITWHR-DGIVLQEDAHTQFPERGRFLQLQALSTADS 2365
Query: 511 GMYRCQTSQYNG-----FNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLR 565
G Y C G F V+ V I PPAV + +++ + C +
Sbjct: 2366 GDYSCTARNAAGSTSVAFRVEIH--TVPTIRSGPPAVNVSV-------NQTALLPC---Q 2413
Query: 566 AYPIRVLTYEWRLGNKLL--RTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGR 621
A + WR L R+ +F+ ++ + ++ G Y C N AG+ R
Sbjct: 2414 ADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR 2471
Score = 107 bits (268), Expect = 4e-23
Identities = 127/478 (26%), Positives = 186/478 (38%), Gaps = 67/478 (14%)
Query: 49 VYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRY 108
V + E E L L C +G PRP I W K + + + LRI + G Y
Sbjct: 2675 VRAVAEEEVL-LPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY 2733
Query: 109 YCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
C A+N GS A+ R+ V PV+ E + FL C A +P
Sbjct: 2734 LCIAKNSAGS-AMGKTRLVVQV--PPVIENGLPDLSTTEGSH----AFLPCKARGSPEPN 2786
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
+W + + + K FT + L +KNL QD Y+C A N
Sbjct: 2787 ITWDKDGQPVSGAEGK--------FTIQPSGELLVKNLEGQDAGTYTCTAE--NAVGRAR 2836
Query: 229 KMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT 288
+ V + P L D + G+ + L C G P P + W + + E
Sbjct: 2837 RRVHLTI---LVLPVFTTLPGDRSL-RLGDRLWLRCAARGS-PTPRIGWTVNDRPVTEGV 2891
Query: 289 VLN--GGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRA--LKKGRFWITPDPYH 344
G TL A++ +D+GTY C A N VG S + A L+ F +P
Sbjct: 2892 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP-- 2949
Query: 345 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDI 404
+G +++ C V P ++ W K+G PLR S Q +L I
Sbjct: 2950 ------VGGSIQLDCVVRGDPVPDI--HWIKDGLPLRGSHLRHQLQNG--------SLTI 2993
Query: 405 IDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQ 464
+ D G Y C+A + G + I V S+ P PQ+ + R GD + L+
Sbjct: 2994 RRTERDDAGRYQCLAENEMGVAKKVVILVLQSA---PVFQVEPQD---MTVRSGDDVALR 3047
Query: 465 CQVTGKPKPIILWSRADKEV-------AMPDGSMQMESYDGTLRIVNVSREMSGMYRC 515
CQ TG+P P I W +A + + +PDGS+ +E NV +G Y C
Sbjct: 3048 CQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLE---------NVETGDAGTYDC 3096
Score = 99.8 bits (247), Expect = 1e-20
Identities = 139/579 (24%), Positives = 219/579 (37%), Gaps = 74/579 (12%)
Query: 58 LELTCLVTGHPRPQIRWTKTA----GSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAE 113
L L C V P P+I W + A +F + F L++ + G Y C A
Sbjct: 2317 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF---LQLQALSTADSGDYSCTAR 2373
Query: 114 NGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRR 173
N GS ++ + RV+++ V T+ G +T L C A+ P SWR+
Sbjct: 2374 NAAGSTSV-AFRVEIH----TVPTIRS--GPPAVNVSVNQTALLPCQADGVPAPLVSWRK 2426
Query: 174 GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSF 233
+ L S P F L+++ + QD +Y C+AS N +
Sbjct: 2427 DRVPLDPRS--------PRFEILPEGSLRIQPVLAQDAGHYLCLAS--NSAGSDRQGRDL 2476
Query: 234 RLSNKTA---SPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT-- 288
R+ A SPS L + P EA G P P + W + L +
Sbjct: 2477 RVLEPPAIAPSPSNLTLTAHTPALLPCEA--------SGSPKPLVVWWKDGQKLDFRLQQ 2528
Query: 289 ----VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH 344
+L L + A D+ + C+ +N VG A + + V I D
Sbjct: 2529 GAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGE-AHRLYQVTVHVPPT----IADD--Q 2581
Query: 345 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDI 404
D + + V ++C +P+ T SW K G L + + VSP L+I
Sbjct: 2582 TDFTVTMMAPVVLTCHSTGIPAP--TVSWSKAGAQLGARG------SGYRVSPSGA-LEI 2632
Query: 405 IDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTRE--GDTIE 462
G YTC A G++ + + + +S V L P V R + +
Sbjct: 2633 GQALPIHAGRYTCSAR-NSAGVAHKHVFLTVQASPVVKPL-------PSVVRAVAEEEVL 2684
Query: 463 LQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNG 522
L C+ +G P+P I W + VA + + G LRI + S E +G Y C G
Sbjct: 2685 LPCEASGIPRPTITWQKEGLNVATGVSTQVLPG--GQLRIAHASPEDAGNYLCIAKNSAG 2742
Query: 523 FNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKL 582
+ +L+VQ PP +E ++ + + C+ R P +T++
Sbjct: 2743 SAM----GKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA-RGSPEPNITWDKDGQPVS 2797
Query: 583 LRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGR 621
G+F Q E VK+L ++ G Y C+ N G R
Sbjct: 2798 GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRAR 2836
Score = 93.2 bits (230), Expect = 1e-18
Identities = 135/605 (22%), Positives = 229/605 (37%), Gaps = 74/605 (12%)
Query: 47 ERVYTIREGETLELTCLVTGHPRPQIRWTKTAGS-ASDRFQDSSVFNETLRITNIQRHQG 105
E V + +G+T L C VTGHP+P++ W K A S L++
Sbjct: 1170 EEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSA 1229
Query: 106 GRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNP 165
G Y C A N +G K ++ V L ++ + + + + L C A + P
Sbjct: 1230 GHYSCIAANAVGEKT-KHFQLSV-LLAPTILGGAEDSADEEVTVTVNNPISLICEALAFP 1287
Query: 166 PVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCN 225
+W + + + +++ T L++ N + +D Y+C+ V N
Sbjct: 1288 SPNITWMKDGAPF--EASRNIQLLP------GTHGLQILNAQKEDAGQYTCV-----VTN 1334
Query: 226 IPDKMVSFRLSNKTASPSIKLLVDDPIV--------VNPGEAITLVCVTTGGEPAPSLTW 277
+ V PSI DDP+ +TL C + P P++ W
Sbjct: 1335 ELGEAVKNYHVEVLIPPSIS--KDDPLAEVGVKEVKTKVNSTLTLEC-ESWAVPPPTIRW 1391
Query: 278 VRSFGTLPEKTVL----NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRA--- 330
+ + + L G L I D+G Y C+A N G + N++++
Sbjct: 1392 YKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGED-DQDFNVLIQVPPM 1450
Query: 331 -LKKGRFWITPDPYHKDDNIQIG----REV------KISCQVEAVPSEELTFSWFKNGRP 379
K G F + +++ + G RE+ + C A+P +LT W++ +P
Sbjct: 1451 FQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLT--WYREDQP 1508
Query: 380 LRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSST 439
L + + + + Q G L I ++ + G Y+C AS + + + + T
Sbjct: 1509 LSAGDEVSVLQ-------GGRVLQIPLVRAENAGRYSCKAS---NEVGEDWLHYELLVLT 1558
Query: 440 VPPNLTVPQEKSPLVT-REGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDG 498
P L +E VT T+ LQC G P P I W + + P +Q+
Sbjct: 1559 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS-PSPRLQVLEDGQ 1617
Query: 499 TLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLE-IRQGQDRSV 557
L++ + Y C G E L L VQ PP + LE + + SV
Sbjct: 1618 VLQVSTAEVADAASYMCVAENQAG----SAEKLFTLRVQVPPRIAGLDLEQVTAILNSSV 1673
Query: 558 TMSCRVLRAYPIRVLTYEWRLGNKLLRTGQ----FDSQEYTEYAVKSLSNENYGVYNCSI 613
++ C V A+P +T W ++ L G+ + LS+ G+Y C
Sbjct: 1674 SLPCDV-HAHPNPEVT--WYKDSQALSLGEEVFLLPGTHTLQLGRARLSDS--GMYTCEA 1728
Query: 614 INEAG 618
+N AG
Sbjct: 1729 LNAAG 1733
Score = 84.0 bits (206), Expect = 6e-16
Identities = 133/580 (22%), Positives = 219/580 (37%), Gaps = 63/580 (10%)
Query: 56 ETLELTCLVTGHPRPQIRWTKTAGSASDR-FQDSSVFNETLRITNIQRHQGGRYYCKAEN 114
E++ L C P P + W K R S L++ G Y C+A N
Sbjct: 804 ESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALN 863
Query: 115 GLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRG 174
G K ++V+ PV + +S + + R L C P + SWR+
Sbjct: 864 QAGHSE-KHYNLNVWVA--PVFPLRESHTLTVREGHPTR---LSCECRGVPFPKISWRKD 917
Query: 175 QEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFR 234
+ L G G++ ++L L + Y+C S + D +
Sbjct: 918 GQPL-PGEGAGLQ-----HVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVH 971
Query: 235 LSNKTASPSIKLLVDDPI---VVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN 291
+ + A P + P VV G A TL C TG +P P++TW R + + L
Sbjct: 972 VPPQIAGPR-----EPPTQVSVVQDGVA-TLECNATG-KPPPTVTWERDGQPVGAELGLQ 1024
Query: 292 ----GGTLTIPAITSDDAGTYSCIANNNVGNPAKK-STNIIVRALKKGRFWITPDPYHKD 346
G +L + + G YSC+A N G +K +++V G DP
Sbjct: 1025 LQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDL----DPL--- 1077
Query: 347 DNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 406
NI ++ EA+ WF+ P+ E D + G L +
Sbjct: 1078 TNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGE-------DTYLLAGGWMLKMTQ 1130
Query: 407 LKFTDFGTYTCVASLKGGGIS-DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQC 465
+ D G Y+C+AS + G + S++V VPP++ + + +G T L C
Sbjct: 1131 TQEQDSGLYSCLASNEAGEARRNFSVEV-----LVPPSIENEDLEEVIKVLDGQTAHLMC 1185
Query: 466 QVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT-LRIVNVSREMSGMYRCQTSQYNGFN 524
VTG P+P + W + + +A G S DG L+++ + +G Y C + G
Sbjct: 1186 NVTGHPQPKLTWFKDGRPLAR--GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEK 1243
Query: 525 VKPREALVQLIVQYPPAV-----EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLG 579
K QL V P + + A E+ + +++ C L A+P +T+ + G
Sbjct: 1244 TKH----FQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEAL-AFPSPNITW-MKDG 1297
Query: 580 NKLLRTGQFDSQEYTE-YAVKSLSNENYGVYNCSIINEAG 618
+ T + + E+ G Y C + NE G
Sbjct: 1298 APFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1337
Score = 76.3 bits (186), Expect = 1e-13
Identities = 124/579 (21%), Positives = 210/579 (36%), Gaps = 68/579 (11%)
Query: 58 LELTCLVTGHPRPQIRWTKTAGSASDRFQDS-SVF--NETLRITNIQRHQGGRYYCKAEN 114
+ LTC TG P P + W K S VF L + + + GRY C A +
Sbjct: 713 VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVS 772
Query: 115 GLGSPAIKSIRVDVYYLDDPVVTVHQSIG----EAKEQFYYERTVFLRCVANSNPPVRYS 170
+G D V+ VH E +V L C +++ PP S
Sbjct: 773 AVGEDR-----------QDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 821
Query: 171 WRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKM 230
W + + +E + +L++ D +Y+C A N +K
Sbjct: 822 WWK--------DGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEA--LNQAGHSEKH 871
Query: 231 VSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP----- 285
+ N +P L + V G L C G P P ++W + LP
Sbjct: 872 YNL---NVWVAPVFPLRESHTLTVREGHPTRLSC-ECRGVPFPKISWRKDGQPLPGEGAG 927
Query: 286 -EKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH 344
+ G L + GTY+C +N VGN + + + V + P
Sbjct: 928 LQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGN-SSQDLQLEVHVPPQ-----IAGPRE 981
Query: 345 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDI 404
+ + ++ + + A T +W ++G+P+ + + + +L +
Sbjct: 982 PPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQG-------QSLHV 1034
Query: 405 IDLKFTDFGTYTCVA-SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTRE-GDTIE 462
+ G Y+CVA +L G + V VPP L + +T +
Sbjct: 1035 ERAQAAHTGRYSCVAENLAGRAERKFELSV-----LVPPELIGDLDPLTNITAALHSPLT 1089
Query: 463 LQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNG 522
L C+ G P P I W R ++ V+ P + + L++ + SG+Y C S N
Sbjct: 1090 LLCEAMGIPPPAIRWFRGEEPVS-PGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS--NE 1146
Query: 523 FNVKPREALVQLIVQYPPAVEPAFLE--IRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGN 580
R V+++V PP++E LE I+ ++ + C V +P LT+ ++ G
Sbjct: 1147 AGEARRNFSVEVLV--PPSIENEDLEEVIKVLDGQTAHLMCNV-TGHPQPKLTW-FKDGR 1202
Query: 581 KLLR-TGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAG 618
L R S + V + + G Y+C N G
Sbjct: 1203 PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVG 1241
Score = 75.5 bits (184), Expect = 2e-13
Identities = 73/289 (25%), Positives = 125/289 (43%), Gaps = 31/289 (10%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYC 110
++R G+ L L C G P P+I WT ++ + TL+ + R G Y C
Sbjct: 2857 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDG-GSTLQRAAVSREDSGTYVC 2915
Query: 111 KAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYE--RTVFLRCVANSNPPVR 168
AEN +G S V+ + PV+ GEA ++ L CV +P
Sbjct: 2916 WAENRVGRTQAVSF---VHVKEAPVLQ-----GEAFSYLVEPVGGSIQLDCVVRGDPVPD 2967
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
W + + L+GS ++ + L ++ D Y C+A N +
Sbjct: 2968 IHWIK-DGLPLRGSHLRHQL--------QNGSLTIRRTERDDAGRYQCLAE--NEMGVAK 3016
Query: 229 KMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT 288
K+V L + +P ++ D + V G+ + L C TG EP P++ W+++ L
Sbjct: 3017 KVVILVLQS---APVFQVEPQD-MTVRSGDDVALRCQATG-EPTPTIEWLQAGQPLRASR 3071
Query: 289 ---VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKG 334
L G+L + + + DAGTY C+A+N +G+ ++ ++VR +G
Sbjct: 3072 RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAF-LVVRGEPQG 3119
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 123 bits (308), Expect = 9e-28
Identities = 145/612 (23%), Positives = 248/612 (40%), Gaps = 75/612 (12%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGS-ASDRFQDSSVFNE--TLRITNIQRHQGGR 107
T+ GET L C V G P + W K S + S +N+ +LRI +++R G
Sbjct: 5714 TVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGT 5773
Query: 108 YYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPV 167
Y + +N +G + ++ VDV D V + + L C + P+
Sbjct: 5774 YTFQVQNNVGKSSCTAV-VDV---SDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPI 5829
Query: 168 RYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIP 227
+W + ++ G+ Y+ F+ L+L +L D NY+C+A+ NV
Sbjct: 5830 SVAWFHEKTKIVSGAK-----YQTTFSDNVCT-LQLNSLDSSDMGNYTCVAA--NVAGSD 5881
Query: 228 DKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK 287
+ R P + +P+ V PG+ +T V G P + W R L +
Sbjct: 5882 E----CRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPF-KVNWFRGARELVKG 5936
Query: 288 TVLN------GGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPD 341
N L + I +G Y+C+ +NN G A +T + V+ P
Sbjct: 5937 DRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQ-ASCTTRLFVKE---------PA 5986
Query: 342 PYHK---DDNIQIGREVKI-SCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSP 397
+ K D +++ G+ + + S +P ++ +W K+G + +SE+ I T+
Sbjct: 5987 AFLKRLSDHSVEPGKSIILESTYTGTLP---ISVTWKKDGFNITTSEKCNIVTTEK---- 6039
Query: 398 GTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTRE 457
T L+I++ D G Y+C + G + + S+ PP E PL
Sbjct: 6040 -TCILEILNSTKRDAGQYSCEIENEAGR----DVCGALVSTLEPPYFVT--ELEPLEAAV 6092
Query: 458 GDTIELQCQVTGKPKPIILWSRADKEV-AMPDGSMQMESYDGTLRIVNVSREMSGMYRCQ 516
GD++ LQCQV G P+ + W + D ++ P+ + TL V+ SG Y C+
Sbjct: 6093 GDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCK 6152
Query: 517 TSQYNG-------FNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPI 569
G F ++ R Q PP+ +I Q VT++CR+ + PI
Sbjct: 6153 AENSIGTASSKTVFRIQER--------QLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPI 6204
Query: 570 RVLTYEWRL---GNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLV 626
+V Y + ++ L+T D+ + LS+ G Y+CS N G S +
Sbjct: 6205 QVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHS--GQYSCSASNPLGTASSSARL 6262
Query: 627 TGKAYAPEFYYD 638
T + ++D
Sbjct: 6263 TAREPKKSPFFD 6274
Score = 122 bits (307), Expect = 1e-27
Identities = 141/597 (23%), Positives = 238/597 (39%), Gaps = 60/597 (10%)
Query: 50 YTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNET---LRITNIQRHQGG 106
+++ G+++ L TG + W K + + + + V E L I N + G
Sbjct: 5995 HSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAG 6054
Query: 107 RYYCKAENGLGSPAIKSI--RVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSN 164
+Y C+ EN G ++ ++ Y + + ++G++ V L+C
Sbjct: 6055 QYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDS---------VSLQCQVAGT 6105
Query: 165 PPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVC 224
P + SW +G L + Y +FT ++ + D Y+C A N
Sbjct: 6106 PEITVSWYKGDTKLRPTPE-----YRTYFTNNVATLV-FNKVNINDSGEYTCKAE--NSI 6157
Query: 225 NIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTW------V 278
FR+ + PS + D I G +TL C G P + W +
Sbjct: 6158 GTASSKTVFRIQERQLPPSFARQLKD-IEQTVGLPVTLTCRLNGSAPI-QVCWYRDGVLL 6215
Query: 279 RSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWI 338
R L V N TL I +G YSC A+N +G A S + R KK F+
Sbjct: 6216 RDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGT-ASSSARLTAREPKKSPFF- 6273
Query: 339 TPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPG 398
D ++ G C V ++ + +W K+ + +R IT
Sbjct: 6274 --DIKPVSIDVIAGESADFECHVTG--AQPMRITWSKDNKEIRPGGNYTITCVG-----N 6324
Query: 399 TTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTV--PPNLTVPQEKSPLVTR 456
T +L I+ + D G YTC A+ +D+ D+ + +V PP E S V +
Sbjct: 6325 TPHLRILKVGKGDSGQYTCQAT------NDVGKDMCSAQLSVKEPPKFVKKLEASK-VAK 6377
Query: 457 EGDTIELQCQVTGKPKPIILWSRADKEVAMP-DGSMQMESYDGTLRIVNVSREMSGMYRC 515
+G++I+L+C+++G P+ + W R D E+ +M + L I S E SG Y C
Sbjct: 6378 QGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYIC 6437
Query: 516 QTSQYNGFNVKPREALVQLIVQYPPAV--EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLT 573
+ +NG V L V+ PP +P+ + +G D V + C + P V+
Sbjct: 6438 EA--HNG--VGDASCSTALTVKAPPVFTQKPSPVGALKGSD--VILQCEISGTPPFEVVW 6491
Query: 574 YEWRLGNKLLRTGQFDSQEY-TEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGK 629
+ R + + + S+ + T + +L + G Y+C NE G+ CS V K
Sbjct: 6492 VKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFK 6548
Score = 115 bits (287), Expect = 3e-25
Identities = 140/595 (23%), Positives = 229/595 (38%), Gaps = 72/595 (12%)
Query: 50 YTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF---NETLRITNIQRHQGG 106
Y + GE+ L C + G P Q+ W K S+ F L IT+++ G
Sbjct: 3747 YLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSG 3806
Query: 107 RYYCKAENGLGSPAIKSIRVDVYYLDDP--VVTVHQSIGEAKEQFYYERTVFLRCVANSN 164
Y C+A N +GS S ++ + P + T+ + L+C +
Sbjct: 3807 SYSCEAVNDVGS---DSCSTEIVIKEPPSFIKTLEPA------DIVRGTNALLQCEVSGT 3857
Query: 165 PPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVC 224
P SW + ++ + S K + F+Q L++ + D Y C+ V
Sbjct: 3858 GPFEISWFKDKKQI--RSSKKYRL----FSQKSLVCLEIFSFNSADVGEYECV-----VA 3906
Query: 225 NIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL 284
N K P+ VDD I + G+ +TL G EP S+TW++ +
Sbjct: 3907 NEVGKCGCMATHLLKEPPTFVKKVDDLIALG-GQTVTLQAAVRGSEPI-SVTWMKGQEVI 3964
Query: 285 PE-----KTVLNG-GTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWI 338
E + NG L IP + G Y+C+A N G+ I+ K
Sbjct: 3965 REDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAK------ 4018
Query: 339 TPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPG 398
+ + IQ+ + + + EL W+K+GRPL +S++ I+
Sbjct: 4019 ---IIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRIS-----FKNN 4070
Query: 399 TTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREG 458
L + D G YT S + G S + + P T P V
Sbjct: 4071 VAQLKFYSAELHDSGQYTFEISNEVGS-SSCETTFTVLDRDIAPFFTKPLRNVDSVV--N 4127
Query: 459 DTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT--LRIVNVSREMSGMYRCQ 516
T L C++ G + W + KE+A D ++ +GT L I+ V +G + C+
Sbjct: 4128 GTCRLDCKIAGSLPMRVSWFKDGKEIAASD-RYRIAFVEGTASLEIIRVDMNDAGNFTCR 4186
Query: 517 TSQYNGFNVKPREALVQLIVQYPPA--VEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTY 574
+ +V +++ LIVQ PP+ +P ++ G +V + + P LT
Sbjct: 4187 ATN----SVGSKDSSGALIVQEPPSFVTKPGSKDVLPGS--AVCLKSTFQGSTP---LTI 4237
Query: 575 EWRLGNKLLRTGQFDSQEYTEYAVKS------LSNENYGVYNCSIINEAGAGRCS 623
W GNK L +G S T+ A++S + + G Y C + N AG CS
Sbjct: 4238 RWFKGNKELVSG--GSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECS 4290
Score = 110 bits (276), Expect = 5e-24
Identities = 133/604 (22%), Positives = 241/604 (39%), Gaps = 58/604 (9%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNET---LRITNIQRHQGGRYYCK 111
G+ + T ++ G P ++ W + A + + F +T L + NI Q G Y C
Sbjct: 5907 GKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCV 5966
Query: 112 AENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSW 171
N G + + ++ +P + + + E +++ L P+ +W
Sbjct: 5967 VSNNAGQASCTTR----LFVKEPAAFLKRLSDHSVEP---GKSIILESTYTGTLPISVTW 6019
Query: 172 RRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMV 231
++ + + T +T IL++ N +D YSC ++ +V
Sbjct: 6020 KKDGFNITTSEKCNI------VTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALV 6073
Query: 232 SFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL---PEKT 288
S T P + +P+ G++++L C G P +++W + L PE
Sbjct: 6074 S------TLEPPYFVTELEPLEAAVGDSVSLQC-QVAGTPEITVSWYKGDTKLRPTPEYR 6126
Query: 289 VL---NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHK 345
N TL + +D+G Y+C A N++G + K+ I F K
Sbjct: 6127 TYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSF----ARQLK 6182
Query: 346 DDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDII 405
D +G V ++C++ S + W+++G LR E + + D L I+
Sbjct: 6183 DIEQTVGLPVTLTCRLNG--SAPIQVCWYRDGVLLRDDENLQTSFVD-----NVATLKIL 6235
Query: 406 DLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQC 465
+ G Y+C AS G S S + P + ++ G++ + +C
Sbjct: 6236 QTDLSHSGQYSCSASNPLGTASS-SARLTAREPKKSPFFDIKPVSIDVIA--GESADFEC 6292
Query: 466 QVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT--LRIVNVSREMSGMYRCQTSQYNGF 523
VTG I WS+ +KE+ P G+ + T LRI+ V + SG Y CQ + G
Sbjct: 6293 HVTGAQPMRITWSKDNKEIR-PGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGK 6351
Query: 524 NVKPREALVQLIVQYPPA-VEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKL 582
++ QL V+ PP V+ Q S+ + C++ + I+V + R ++L
Sbjct: 6352 DM----CSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWF--RNDSEL 6405
Query: 583 LRTGQFDSQEYTEYAVKSL---SNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDT 639
+ +++ A+ ++ S E+ G Y C N G CS +T K AP +
Sbjct: 6406 HESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVK--APPVFTQK 6463
Query: 640 YNPV 643
+PV
Sbjct: 6464 PSPV 6467
Score = 108 bits (270), Expect = 2e-23
Identities = 136/596 (22%), Positives = 237/596 (39%), Gaps = 81/596 (13%)
Query: 55 GETLELTCLVTGHPRPQIRWTK------TAGSASDRFQDSSVFNETLRITNIQRHQGGRY 108
GE L C V G P +I W K +A + +F+++ +L I + G Y
Sbjct: 7034 GEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVA---SLVINKVDHSDVGEY 7090
Query: 109 YCKAENGLGSPA------IKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVAN 162
CKA+N +G+ A IK+ ++ ++ + VH+++G V C N
Sbjct: 7091 SCKADNSVGAVASSAVLVIKARKLPPFFARK-LKDVHETLGFP---------VAFECRIN 7140
Query: 163 SNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRN 222
+ P++ SW + +L ++ T L++ Y+C AS N
Sbjct: 7141 GSEPLQVSWYKDGVLLKDDANLQTSFVHNVAT------LQILQTDQSHIGQYNCSAS--N 7192
Query: 223 VCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNP--GEAITLVCVTTGGEPAPSLTW--- 277
LS P L P+ V+ GE+ T C TG P +TW
Sbjct: 7193 PLGTASSSAKLILSEHEVPPFFDL---KPVSVDLALGESGTFKCHVTGTAPI-KITWAKD 7248
Query: 278 ---VRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKG 334
+R G V N TLT+ + DAG Y+C A+N G K S + + +
Sbjct: 7249 NREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAG---KDSCSAQLGVQEPP 7305
Query: 335 RF--WITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTD 392
RF + P K D + C++ P E+ W+K+ ++ S + ++ D
Sbjct: 7306 RFIKKLEPSRIVKQDEF-----TRYECKIGGSP--EIKVLWYKDETEIQESSKFRMSFVD 7358
Query: 393 PDVSPGTTNLDIIDLKFTDFGTYTCVA-SLKGGGISDISIDVNISSSTVPPNLTVPQEKS 451
L++ +L D G YTC A + G S S+ V PP ++
Sbjct: 7359 -----SVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVK-----EPP--IFRKKPH 7406
Query: 452 PLVTREGDTIELQCQVTGKPKPIILWSRADKEV-AMPDGSMQMESYDGTLRIVNVSREMS 510
P+ T +G + L+C++ G P + W + +E+ + + E++ ++ I+NV
Sbjct: 7407 PIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADI 7466
Query: 511 GMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIR 570
G Y+C+ + +V + + ++ PP +I + V + + A PI
Sbjct: 7467 GEYQCKATN----DVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPIS 7522
Query: 571 VLTYEWRLGNKLLRTGQFDSQEYTE----YAVKSLSNENYGVYNCSIINEAGAGRC 622
V+ ++ + +++R Y+E + N G Y C I N+AG C
Sbjct: 7523 VVWFKDK--GEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQEC 7576
Score = 103 bits (256), Expect = 1e-21
Identities = 138/585 (23%), Positives = 226/585 (38%), Gaps = 66/585 (11%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNET---LRITNIQRHQGGRY 108
+++G+ +L C VTG P +I W + + F E+ LR+T++ G Y
Sbjct: 4311 LKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEY 4370
Query: 109 YCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
C+A+N GS SI V + P T E +++ V L PP
Sbjct: 4371 MCEAQNEAGSDHCSSI---VIVKESPYFTKEFKPIEVLKEY----DVMLLAEVAGTPPFE 4423
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
+W + +L G Y+ F Q L++ D Y C + +I
Sbjct: 4424 ITWFKDNTILRSGRK-----YKTFI-QDHLVSLQILKFVAADAGEYQCRVTNEVGSSICS 4477
Query: 229 KMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT 288
V+ R PS ++ + G A T G ++TW++ + E
Sbjct: 4478 ARVTLR-----EPPSFIKKIESTSSLRGGTA--AFQATLKGSLPITVTWLKDSDEITEDD 4530
Query: 289 VL------NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDP 342
+ N +L + I G Y C A N+ G + + K IT +
Sbjct: 4531 NIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSV-----KEPATITEEA 4585
Query: 343 YHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNL 402
+I + + + QV+ ++E+T WFK+G+ L + I+ TD + L
Sbjct: 4586 V----SIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDT-----VSIL 4636
Query: 403 DIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIE 462
II + D G YT G S +N+ +PP+ T +K + +G I+
Sbjct: 4637 KIISTEKKDSGEYTFEVQ-NDVGRSSCKARINVLDLIIPPSFTKKLKKMDSI--KGSFID 4693
Query: 463 LQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT--LRIVNVSREMSGMYRCQTSQY 520
L+C V G I W + D+E++ + + +D T L I + SG Y C +
Sbjct: 4694 LECIVAGSHPISIQWFKDDQEISASE-KYKFSFHDNTAFLEISQLEGTDSGTYTCSATNK 4752
Query: 521 NGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRV-LRAY--PIRVLTYEWR 577
G N + L V+ P P F+E Q QD V + RV L+A +T +W
Sbjct: 4753 AGHN----QCSGHLTVKEP----PYFVEKPQSQD--VNPNTRVQLKALVGGTAPMTIKWF 4802
Query: 578 LGNKLLRTGQ----FDSQEYTEYAVKSLSNENYGVYNCSIINEAG 618
NK L +G + T + + + G Y C + N+ G
Sbjct: 4803 KDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVG 4847
Score = 102 bits (254), Expect = 2e-21
Identities = 126/597 (21%), Positives = 229/597 (38%), Gaps = 54/597 (9%)
Query: 50 YTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNE---TLRITNIQRHQGG 106
Y+I +G+ L L TG P + W K + + + + E L I + G
Sbjct: 7877 YSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAG 7936
Query: 107 RYYCKAENGLG--SPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSN 164
+Y C EN G S + + + ++ Y + V S+G++ L+C
Sbjct: 7937 QYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSAS---------LQCQLAGT 7987
Query: 165 PPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVC 224
P + SW +G L + Y+ F + L + D Y C A N
Sbjct: 7988 PEIGVSWYKGDTKL-----RPTTTYKMHF-RNNVATLVFNQVDINDSGEYICKA--ENSV 8039
Query: 225 NIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL 284
+ + PS + D + G + C +G EP S++W + L
Sbjct: 8040 GEVSASTFLTVQEQKLPPSFSRQLRD-VQETVGLPVVFDCAISGSEPI-SVSWYKDGKPL 8097
Query: 285 PEKTVL------NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWI 338
+ + N TL I AG YSC A N +G+ + + I+ F I
Sbjct: 8098 KDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDI 8157
Query: 339 TPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPG 398
P + +G C V ++ + SW K+ R +RS + I+ +
Sbjct: 8158 RLAPV----DAVVGESADFECHVTG--TQPIKVSWAKDSREIRSGGKYQISYLE-----N 8206
Query: 399 TTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREG 458
+ +L ++ + D G YTC A + G + +NI +PP+ T ++ T EG
Sbjct: 8207 SAHLTVLKVDKGDSGQYTCYA-VNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEET-EG 8264
Query: 459 DTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT--LRIVNVSREMSGMYRCQ 516
++ +L+ +V G + W + + E+ P + ++ + T L++ +G+Y C+
Sbjct: 8265 NSFKLEGRVAGSQPITVAWYKNNIEI-QPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCK 8323
Query: 517 TSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEW 576
S G + ++V + PP + + + V +SC V + PIR+ +W
Sbjct: 8324 VSNDAG-SALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRI---QW 8379
Query: 577 RLGNKLLRTGQFDSQEYTE----YAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGK 629
+ ++ S + ++ ++ + G Y C N AG+ VT K
Sbjct: 8380 LKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIK 8436
Score = 100 bits (250), Expect = 5e-21
Identities = 133/614 (21%), Positives = 243/614 (39%), Gaps = 72/614 (11%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGSA--SDR----FQDSSVFNETLRITNIQRHQGGRY 108
G + T +V G P + W K + DR +DS L + ++ Q G Y
Sbjct: 7789 GTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVA---ELELFDVDTSQSGEY 7845
Query: 109 YCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
C N G K+ Y+ P V + + E+ + + L PP+
Sbjct: 7846 TCIVSNEAG----KASCTTHLYIKAPAKFVKRLNDYSIEK---GKPLILEGTFTGTPPIS 7898
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCI---ASVRNVCN 225
+W++ + + E ++ IL++ + +D Y+C AS ++ C+
Sbjct: 7899 VTWKKNGINVTPSQRCNITTTE------KSAILEIPSSTVEDAGQYNCYIENASGKDSCS 7952
Query: 226 IPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP 285
++ P + +P+ V+ G++ +L C G P ++W + L
Sbjct: 7953 AQILILE---------PPYFVKQLEPVKVSVGDSASLQC-QLAGTPEIGVSWYKGDTKLR 8002
Query: 286 EKTVL------NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWIT 339
T N TL + +D+G Y C A N+VG ST + V+ K +
Sbjct: 8003 PTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGE-VSASTFLTVQEQK-----LP 8056
Query: 340 PDPYHKDDNIQ--IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSP 397
P + ++Q +G V C + SE ++ SW+K+G+PL+ S + + D
Sbjct: 8057 PSFSRQLRDVQETVGLPVVFDCAISG--SEPISVSWYKDGKPLKDSPNVQTSFLD----- 8109
Query: 398 GTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTRE 457
T L+I + G Y+C A+ G S S + ++ PP + +P+
Sbjct: 8110 NTATLNIFKTDRSLAGQYSCTATNPIGSASS-SARLILTEGKNPPFFDI--RLAPVDAVV 8166
Query: 458 GDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT--LRIVNVSREMSGMYRC 515
G++ + +C VTG + W++ +E+ G Q+ + + L ++ V + SG Y C
Sbjct: 8167 GESADFECHVTGTQPIKVSWAKDSREIRS-GGKYQISYLENSAHLTVLKVDKGDSGQYTC 8225
Query: 516 QTSQYNGFNVKPREALVQLIVQ---YPPAVEPAFLE-IRQGQDRSVTMSCRVLRAYPIRV 571
Y V QL ++ PP+ E + + + S + RV + PI V
Sbjct: 8226 ----YAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITV 8281
Query: 572 LTYEWRLGNKLLRTGQFDSQEYT-EYAVKSLSNENYGVYNCSIINEAGAGRC-SFLVTGK 629
Y+ + + + + T V+ + G+Y C + N+AG+ C S +V +
Sbjct: 8282 AWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKE 8341
Query: 630 AYAPEFYYDTYNPV 643
P + PV
Sbjct: 8342 PKKPPVFDQHLTPV 8355
Score = 100 bits (249), Expect = 6e-21
Identities = 137/608 (22%), Positives = 230/608 (37%), Gaps = 70/608 (11%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSAS-DRFQDSSVFNE--TLRITNIQRHQGGR 107
T+ G L C+VTG P +W K S D + N+ +L+I + G
Sbjct: 6655 TVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGL 6714
Query: 108 YYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKE-QFYYERTVFLRCVANSNPP 166
Y + +N +G + V V+ D + I + K+ +V L C + + P
Sbjct: 6715 YSFEVKNSVGK---SNCTVSVHVSDR--IVPPSFIRKLKDVNAILGASVVLECRVSGSAP 6769
Query: 167 VRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNI 226
+ W + ++ G E T L L L P D Y+C+A+ N+
Sbjct: 6770 ISVGWFQDGNEIVSGPKCQSSFSENVCT------LNLSLLEPSDTGIYTCVAA-----NV 6818
Query: 227 PDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPE 286
+ PS + D + V PG ++T V G P + W + L
Sbjct: 6819 AGSDECSAVLTVQEPPSFE-QTPDSVEVLPGMSLTFTSVIRGTPPF-KVKWFKGSRELVP 6876
Query: 287 KTVLNGG------TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITP 340
N L + + ++G YSC+ N+ G+ A +T++ V+ P
Sbjct: 6877 GESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGS-ASCTTHLFVK---------EP 6926
Query: 341 DPYHK---DDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSP 397
+ K D +++ G + + P ++ SW K+ + SER IT T+
Sbjct: 6927 ATFVKRLADFSVETGSPIVLEATYTGTP--PISVSWIKDEYLISQSERCSITMTEK---- 6980
Query: 398 GTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTRE 457
+T L+I++ D+ Y+C+ + G I + S PP P E V
Sbjct: 6981 -STILEILESTIEDYAQYSCLIENEAGQ----DICEALVSVLEPPYFIEPLEHVEAVI-- 7033
Query: 458 GDTIELQCQVTGKPKPIILWSRADKEV-AMPDGSMQMESYDGTLRIVNVSREMSGMYRCQ 516
G+ LQC+V G P+ I W + ++ + P MQ ++ +L I V G Y C+
Sbjct: 7034 GEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCK 7093
Query: 517 TSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEW 576
G V LV + PP ++ + V CR+ + P++V W
Sbjct: 7094 ADNSVG-AVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQV---SW 7149
Query: 577 RLGNKLLRTGQFDSQEYTEYA-------VKSLSNENYGVYNCSIINEAG-AGRCSFLVTG 628
LL+ D+ T + + + G YNCS N G A + L+
Sbjct: 7150 YKDGVLLKD---DANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILS 7206
Query: 629 KAYAPEFY 636
+ P F+
Sbjct: 7207 EHEVPPFF 7214
Score = 99.0 bits (245), Expect = 2e-20
Identities = 132/600 (22%), Positives = 231/600 (38%), Gaps = 85/600 (14%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGS--ASDRFQDSSVFN-ETLRITNIQRHQGGRY 108
++ G++ L C + G P ++ W + ASD+++ + + + +++ N+ G +
Sbjct: 5435 VKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDF 5494
Query: 109 YCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
C+A+N GS S V + PV + I E + V L C + PP
Sbjct: 5495 ICEAQNPAGS---TSCSTKVIVKEPPVFSSFPPIVETLK----NAEVSLECELSGTPPFE 5547
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSC-----IASVRNV 223
W + + L+ S K + F T + + N+ D Y C + S V
Sbjct: 5548 VVWYKDKR-QLRSSKKYKIASKNFHTS-----IHILNVDTSDIGEYHCKAQNEVGSDTCV 5601
Query: 224 CNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTW------ 277
C + K P + + + V GE L G +P + W
Sbjct: 5602 CTV-----------KLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPI-FVQWLKEKEE 5649
Query: 278 -VRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRAL----K 332
+R + V N TL +AG Y C N+ G +T +++ K
Sbjct: 5650 VIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEK 5709
Query: 333 KGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTD 392
G +T +G + C+V P EL+ W+K+G+ L SS++ + +
Sbjct: 5710 AGPMTVT-----------VGETCTLECKVAGTP--ELSVEWYKDGKLLTSSQKHKFSFYN 5756
Query: 393 PDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSP 452
++L I+ ++ D GTYT G S + V++S VPP+ T + +
Sbjct: 5757 K-----ISSLRILSVERQDAGTYTFQVQ-NNVGKSSCTAVVDVSDRAVPPSFTRRLKNTG 5810
Query: 453 LVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDG---TLRIVNVSREM 509
V G + L+C+V G + W ++ G+ ++ TL++ ++
Sbjct: 5811 GVL--GASCILECKVAGSSPISVAWFHEKTKIV--SGAKYQTTFSDNVCTLQLNSLDSSD 5866
Query: 510 SGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV--EPAFLEIRQGQDRSVTMSCRVLRAY 567
G Y C + G + E L VQ PP+ EP LE+ G ++VT + +
Sbjct: 5867 MGNYTCVAANVAGSD----ECRAVLTVQEPPSFVKEPEPLEVLPG--KNVTFTSVIRGTP 5920
Query: 568 PIRVLTYEWRLGNKLLRTGQ----FDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCS 623
P +V W G + L G + E + ++ G Y C + N AG C+
Sbjct: 5921 PFKV---NWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCT 5977
Score = 96.7 bits (239), Expect = 9e-20
Identities = 133/598 (22%), Positives = 221/598 (36%), Gaps = 77/598 (12%)
Query: 54 EGETLELTCLVTGHPRPQIRWTKTAGSA--SDRFQDSSV-FNETLRITNIQRHQGGRYYC 110
+G + L C ++G P ++ W K S +F+ +S F+ +L I N++ G Y+C
Sbjct: 6471 KGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHC 6530
Query: 111 KAENGLGSPAIKSIRVDVYYLDDPVVTVHQS-----IGEAKEQFYYERTVFLRCVANSNP 165
KA N +GS V + + P S IG+A E LR +
Sbjct: 6531 KATNEVGSDTCSC---SVKFKEPPRFVKKLSDTSTLIGDAVE---------LRAIVEGFQ 6578
Query: 166 PVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCN 225
P+ W + + +++ S+ T+I + N+ + S + +C
Sbjct: 6579 PISVVWLKDRGEVIRESEN-------------TRISFIDNIATLQLGSPEASNSGKYICQ 6625
Query: 226 IPDKMVSFRLSN--KTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGT 283
I + S P+ + +P+ V G L CV TG P S W +
Sbjct: 6626 IKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTG-TPELSAKWFKDGRE 6684
Query: 284 LPEK-----TVLNG-GTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFW 337
L T +N +L IP D G YS N+VG K + + V +
Sbjct: 6685 LSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVG---KSNCTVSVHVSDR---- 6737
Query: 338 ITPDPYH---KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPD 394
I P + KD N +G V + C+V S ++ WF++G + S +
Sbjct: 6738 IVPPSFIRKLKDVNAILGASVVLECRVSG--SAPISVGWFQDGNEIVSGPKC-----QSS 6790
Query: 395 VSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLV 454
S L++ L+ +D G YTCVA+ G D + TV + Q +
Sbjct: 6791 FSENVCTLNLSLLEPSDTGIYTCVAANVAGS------DECSAVLTVQEPPSFEQTPDSVE 6844
Query: 455 TREGDTIELQCQVTGKPKPIILWSRADKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMY 513
G ++ + G P + W + +E+ + ++ +E + L + V SG Y
Sbjct: 6845 VLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDY 6904
Query: 514 RCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLT 573
C + G L V+ P + + + PI V
Sbjct: 6905 SCLVTNDAG----SASCTTHLFVKEPATFVKRLADFSVETGSPIVLEATYTGTPPISV-- 6958
Query: 574 YEWRLGNKLLRTGQFDSQEYTEYA----VKSLSNENYGVYNCSIINEAGAGRCSFLVT 627
W L+ + S TE + + + E+Y Y+C I NEAG C LV+
Sbjct: 6959 -SWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEALVS 7015
Score = 95.5 bits (236), Expect = 2e-19
Identities = 129/596 (21%), Positives = 215/596 (36%), Gaps = 68/596 (11%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNE---TLRITNIQRHQGGRYYCK 111
G++ L C + G P + W K F TL + + G Y CK
Sbjct: 7975 GDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICK 8034
Query: 112 AENGLGSPAIKSIRVDVYYLDDPVVT-----VHQSIGEAKEQFYYERTVFLRCVANSNPP 166
AEN +G + + P + V +++G V C + + P
Sbjct: 8035 AENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVG---------LPVVFDCAISGSEP 8085
Query: 167 VRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNI 226
+ SW + + L + + T L + YSC A+ N
Sbjct: 8086 ISVSWYKDGKPLKDSPNVQTSFLD------NTATLNIFKTDRSLAGQYSCTAT--NPIGS 8137
Query: 227 PDKMVSFRLSNKTASP--SIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTW------V 278
L+ P I+L D +V GE+ C TG +P ++W +
Sbjct: 8138 ASSSARLILTEGKNPPFFDIRLAPVDAVV---GESADFECHVTGTQPI-KVSWAKDSREI 8193
Query: 279 RSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPA-KKSTNIIVRALKKGRFW 337
RS G + N LT+ + D+G Y+C A N VG + NI R +
Sbjct: 8194 RSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTK 8253
Query: 338 ITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSP 397
+ + + G K+ +V S+ +T +W+KN ++ + IT +
Sbjct: 8254 RLSETVEETE----GNSFKLEGRVAG--SQPITVAWYKNNIEIQPTSNCEITFKN----- 8302
Query: 398 GTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTRE 457
T L + D G YTC S G S + I PP Q +P+ E
Sbjct: 8303 NTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTS-SIVIKEPKKPP--VFDQHLTPVTVSE 8359
Query: 458 GDTIELQCQVTGKPKPIILWSRADKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMYRCQ 516
G+ ++L C V G I W +A +E+ D S S L + +V++ SG Y C+
Sbjct: 8360 GEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCK 8419
Query: 517 TSQYNGFNVKPREALVQLIVQYPPAVEPAFLE-----------IRQGQDRSVTMSCRVLR 565
S G + + ++ PA + A ++ IR + + T +V
Sbjct: 8420 ASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKV-G 8478
Query: 566 AYPIRVLTY---EWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAG 618
PI + + +WR N+ R + + ++ + + G+Y C NE G
Sbjct: 8479 GDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHG 8534
Score = 94.7 bits (234), Expect = 4e-19
Identities = 136/588 (23%), Positives = 223/588 (37%), Gaps = 59/588 (10%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNE---TLRITNIQRHQGGRYYCK 111
G+T+ L V G + W K + + F+ L I ++Q GG+Y C
Sbjct: 3938 GQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCL 3997
Query: 112 AENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSW 171
AEN GS V + +P + ++ Q L P ++ W
Sbjct: 3998 AENEAGSQT----SVGELIVKEPAKIIERA---ELIQVTAGDPATLEYTVAGTPELKPKW 4050
Query: 172 RRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMV 231
+ L+ + + LK + D Y+ + N
Sbjct: 4051 YKDGRPLVASKKYRISF------KNNVAQLKFYSAELHDSGQYTF--EISNEVGSSSCET 4102
Query: 232 SFRLSNKTASPSI-KLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT-- 288
+F + ++ +P K L + VVN L C G P ++W + +
Sbjct: 4103 TFTVLDRDIAPFFTKPLRNVDSVVNG--TCRLDCKIAGSLPM-RVSWFKDGKEIAASDRY 4159
Query: 289 ----VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH 344
V +L I + +DAG ++C A N+VG+ K S+ ++ +++ ++T P
Sbjct: 4160 RIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGS--KDSSGALI--VQEPPSFVTK-PGS 4214
Query: 345 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDI 404
KD + G V + + S LT WFK + L S IT+ + S L++
Sbjct: 4215 KD--VLPGSAVCLKSTFQG--STPLTIRWFKGNKELVSGGSCYITKEALESS-----LEL 4265
Query: 405 IDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQ 464
+K +D GTYTC S GG+ + S ++ + P E S L+ ++GD +L
Sbjct: 4266 YLVKTSDSGTYTCKVSNVAGGV-ECSANLFVKE---PATFVEKLEPSQLL-KKGDATQLA 4320
Query: 465 CQVTGKPKPIILWSRADKEV-AMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGF 523
C+VTG P I W D+E+ M LR+ +V E SG Y C+ G
Sbjct: 4321 CKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGS 4380
Query: 524 NVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL 583
+ +IV+ P F I ++ V + V P + W N +L
Sbjct: 4381 D----HCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEI---TWFKDNTIL 4433
Query: 584 RTGQ----FDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 627
R+G+ F + + G Y C + NE G+ CS VT
Sbjct: 4434 RSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVT 4481
Score = 94.0 bits (232), Expect = 6e-19
Identities = 130/605 (21%), Positives = 220/605 (36%), Gaps = 89/605 (14%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNE---TLRITNIQRHQGGRYYCK 111
G T + G + W K + ++ F +L ++ I+ G+Y C+
Sbjct: 4500 GGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQ 4559
Query: 112 AENGLG---SPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
A+N G A+ S++ + + + V++ + G+ L+ + +
Sbjct: 4560 AKNDAGIQRCSALLSVK-EPATITEEAVSIDVTQGDPAT---------LQVKFSGTKEIT 4609
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
W + + L GS + + + ILK+ + +D Y+ V+N
Sbjct: 4610 AKWFKDGQELTLGSKYKISVTDT------VSILKIISTEKKDSGEYTF--EVQNDVGRSS 4661
Query: 229 KMVSFRLSNKTASPSI--KLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPE 286
+ + PS KL D I G I L C+ G P S+ W + +
Sbjct: 4662 CKARINVLDLIIPPSFTKKLKKMDSI---KGSFIDLECIVAGSHPI-SIQWFKDDQEISA 4717
Query: 287 KTVL------NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITP 340
N L I + D+GTY+C A N G+ G +
Sbjct: 4718 SEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCS-----------GHLTVKE 4766
Query: 341 DPY--HKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPG 398
PY K + + ++ + + +T WFK+ + L S + + D
Sbjct: 4767 PPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDT----- 4821
Query: 399 TTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQE--KSP---L 453
+T+L++ K TD GTY C +S DV ++S + P + K P L
Sbjct: 4822 STSLELFAAKATDSGTYIC----------QLSNDVGTATSKATLFVKEPPQFIKKPSPVL 4871
Query: 454 VTREGDTIELQCQVTGKPKPIILWSRADKEV-AMPDGSMQMESYDGTLRIVNVSREMSGM 512
V R G + +CQ+TG PK + W E+ A+ + T +I E SG
Sbjct: 4872 VLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGT 4931
Query: 513 YRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVL 572
Y C+ G ++L V+ PP + + V + C V P V
Sbjct: 4932 YVCEARNDAG----TASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEV- 4986
Query: 573 TYEWRLGNKLLRTGQFDSQEYTEYAVKSLSN--------ENYGVYNCSIINEAGAGRCSF 624
W N+ +R+ S++YT S+ N + G Y C + NE G+ CS
Sbjct: 4987 --TWLKNNREIRS----SKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCST 5040
Query: 625 LVTGK 629
V K
Sbjct: 5041 RVALK 5045
Score = 93.6 bits (231), Expect = 8e-19
Identities = 134/593 (22%), Positives = 236/593 (39%), Gaps = 68/593 (11%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGSA--SDRFQDSSVFNE-TLRITNIQRHQGGRYYCK 111
GE+ C VTG +I W K ++ + V N TL + + + G+Y C
Sbjct: 7226 GESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCY 7285
Query: 112 AENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFY-YERTVFLRCVANSNPPVRYS 170
A N G + S ++ V + + S +++F YE C +P ++
Sbjct: 7286 ASNIAGKDSC-SAQLGVQEPPRFIKKLEPSRIVKQDEFTRYE------CKIGGSPEIKVL 7338
Query: 171 WRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKM 230
W + + + + S + + +L++ NL +D +Y+C A N
Sbjct: 7339 WYKDETEIQESSKFRMSFVD------SVAVLEMHNLSVEDSGDYTCEA--HNAAGSASSS 7390
Query: 231 VSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL---PEK 287
S K P I PI G + L C G P ++W + L +
Sbjct: 7391 TSL----KVKEPPIFRKKPHPIETLKGADVHLECELQGTPPF-HVSWYKDKRELRSGKKY 7445
Query: 288 TVLNGGTLT---IPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH 344
+++ LT I + + D G Y C A N+VG+ T + ALK P +
Sbjct: 7446 KIMSENFLTSIHILNVDAADIGEYQCKATNDVGS----DTCVGSIALK------APPRFV 7495
Query: 345 K---DDNIQIGREVKISCQVEAVPSEELTFSWFKN-GRPLRSSERMVITQTDPDVSPGTT 400
K D + +G+EV++ +E +E ++ WFK+ G +R S+ + I+ ++
Sbjct: 7496 KKLSDISTVVGKEVQLQTTIEG--AEPISVVWFKDKGEIVRESDNIWISYSE-----NIA 7548
Query: 401 NLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDT 460
L ++ + G YTC +D + ++ +V T+ ++ + GDT
Sbjct: 7549 TLQFSRVEPANAGKYTCQIK------NDAGMQECFATLSVLEPATIVEKPESIKVTTGDT 7602
Query: 461 IELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYD--GTLRIVNVSREMSGMYRCQTS 518
L+C V G P+ W + KE+ D ++ ++ L+I+NV+ SG+Y +
Sbjct: 7603 CTLECTVAGTPELSTKWFKDGKELT-SDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQ 7661
Query: 519 QYNGFNVKPREALVQLIVQ-YPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWR 577
N A +Q+ + PP+ E SV M C+V + PI V +
Sbjct: 7662 --NPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWF--H 7717
Query: 578 LGNKLLRTGQFD---SQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 627
GN++ ++ + V L + G Y C N AG+ CS +T
Sbjct: 7718 EGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLT 7770
Score = 92.0 bits (227), Expect = 2e-18
Identities = 134/613 (21%), Positives = 221/613 (36%), Gaps = 68/613 (11%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGS-ASDRFQDSSVFNET--LRITNIQRHQGGRY 108
+ G+T L C V G P +W K SD S FN+ L+I N+ G Y
Sbjct: 7597 VTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVY 7656
Query: 109 YCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
+ +N +G + + + D V + + +V + C +PP+
Sbjct: 7657 SFEVQNPVGKDSCTAS----LQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPIS 7712
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVR---NVCN 225
SW + G Y+ T T L + L D +Y+CIA+ + C+
Sbjct: 7713 VSWFHEGNEISSGRK-----YQTTLTDN-TCALTVNMLEESDSGDYTCIATNMAGSDECS 7766
Query: 226 IPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP 285
P + P + DP+ V G +T + G P S++W + L
Sbjct: 7767 APLTV---------REPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPF-SVSWFKGSSELV 7816
Query: 286 EKTVLNGGT------LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWIT 339
N L + + + +G Y+CI +N G A +T++ ++A
Sbjct: 7817 PGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGK-ASCTTHLYIKA--------- 7866
Query: 340 PDPYHK---DDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVS 396
P + K D +I+ G+ + + P +T W KNG + S+R IT T+
Sbjct: 7867 PAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVT--WKKNGINVTPSQRCNITTTEKSAI 7924
Query: 397 PGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTR 456
L+I D G Y C G S + I PP ++ P+
Sbjct: 7925 -----LEIPSSTVEDAGQYNCYIE-NASGKDSCSAQILILE---PPYFV--KQLEPVKVS 7973
Query: 457 EGDTIELQCQVTGKPKPIILWSRADKEV-AMPDGSMQMESYDGTLRIVNVSREMSGMYRC 515
GD+ LQCQ+ G P+ + W + D ++ M + TL V SG Y C
Sbjct: 7974 VGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYIC 8033
Query: 516 QTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYE 575
+ G V L + PP+ ++++ V C + + PI V
Sbjct: 8034 KAENSVG-EVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISV---S 8089
Query: 576 WRLGNKLLRTGQFDSQEYTEYA----VKSLSNENYGVYNCSIINEAGAGRCSF-LVTGKA 630
W K L+ + + + G Y+C+ N G+ S L+ +
Sbjct: 8090 WYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEG 8149
Query: 631 YAPEFYYDTYNPV 643
P F+ PV
Sbjct: 8150 KNPPFFDIRLAPV 8162
Score = 89.7 bits (221), Expect = 1e-17
Identities = 135/589 (22%), Positives = 233/589 (39%), Gaps = 63/589 (10%)
Query: 58 LELTCLVTGHPRPQIRWTKT----AGSASDRFQDS-SVFNETLRITNIQRHQGGRYYCKA 112
+EL C VTG P ++ W K S D SVFN L IT G Y C
Sbjct: 4972 VELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFN--LHITKCDPSDTGEYQCIV 5029
Query: 113 ENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWR 172
N GS + S RV + + + + K ++ TV +PP+ +W
Sbjct: 5030 SNEGGSCSC-STRVALKEPPSFIKKIENTTTVLKSSATFQSTVA------GSPPISITWL 5082
Query: 173 RGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVS 232
+ ++L D+ +Y F T L+++++ Y+C A +N + ++ +
Sbjct: 5083 KDDQIL----DEDDNVYISFVDSVAT--LQIRSVDNGHSGRYTCQA--KNESGV-ERCYA 5133
Query: 233 FRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL-- 290
F L + A K D V + +TL CV G P + W++ +
Sbjct: 5134 FLLVQEPAQIVEKAKSVD---VTEKDPMTLECVVAG-TPELKVKWLKDGKQIVPSRYFSM 5189
Query: 291 ----NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKD 346
N + I ++ D+G Y+ N+ G+ S + +R L + K
Sbjct: 5190 SFENNVASFRIQSVMKQDSGQYTFKVENDFGS---SSCDAYLRVLDQNIPPSFTKKLTKM 5246
Query: 347 DNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 406
D + +G + + C+V S ++ WFK+G+ + +S + + + VS L++ +
Sbjct: 5247 DKV-LGSSIHMECKVSG--SLPISAQWFKDGKEISTSAKYRLVCHERSVS-----LEVNN 5298
Query: 407 LKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQ 466
L+ D YTC S G I + PP+ V + + T+E +
Sbjct: 5299 LELEDTANYTCKVSNVAGD----DACSGILTVKEPPSFLVKPGRQQAIP--DSTVEFKAI 5352
Query: 467 VTGKPKPIILWSRADKE-VAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNV 525
+ G P I W + D E V+ P + +E L + +V +G Y C + +V
Sbjct: 5353 LKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTN----DV 5408
Query: 526 KPREALVQLIVQYPPAVEPAF--LEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL 583
L+V PP +I + D S + C++ + IRV+ + R ++L
Sbjct: 5409 GSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSS-RLECKIAGSPEIRVVWF--RNEHELP 5465
Query: 584 RTGQFDSQEYTEYAV---KSLSNENYGVYNCSIINEAGAGRCSFLVTGK 629
+ ++ AV +LS E+ G + C N AG+ CS V K
Sbjct: 5466 ASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVK 5514
Score = 88.2 bits (217), Expect = 3e-17
Identities = 133/605 (21%), Positives = 232/605 (38%), Gaps = 95/605 (15%)
Query: 58 LELTCLVTGHPRPQIRWTKT-----AGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKA 112
++L LV G I+W K +G+A ++D + + +L + + G Y C+
Sbjct: 4785 VQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDT--STSLELFAAKATDSGTYICQL 4842
Query: 113 ENGLGSPAIKS---IRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRY 169
N +G+ K+ ++ ++ P + G++ T F C P +R
Sbjct: 4843 SNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQS--------TTF-ECQITGTPKIRV 4893
Query: 170 SWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDK 229
SW + G+ + T ++ R ++ Y C A
Sbjct: 4894 SWYLDGNEITAIQKHGISFIDGLAT------FQISGARVENSGTYVCEA----------- 4936
Query: 230 MVSFRLSNKTASPSIKLLVDDPIV----VNPGEAIT-----LVCVTTGGEPAPSLTWVRS 280
R TAS SI+L V +P + P E + L C TG P +TW+++
Sbjct: 4937 ----RNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPF-EVTWLKN 4991
Query: 281 FG--------TLPEK-TVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRAL 331
TL ++ +V N L I D G Y CI +N G ST + AL
Sbjct: 4992 NREIRSSKKYTLTDRVSVFN---LHITKCDPSDTGEYQCIVSNE-GGSCSCSTRV---AL 5044
Query: 332 KKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQT 391
K+ P K +N + + Q S ++ +W K+ + L + + I+
Sbjct: 5045 KE-----PPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFV 5099
Query: 392 DPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKS 451
D L I + G YTC A + G ++ + V + ++
Sbjct: 5100 D-----SVATLQIRSVDNGHSGRYTCQAKNESG------VERCYAFLLVQEPAQIVEKAK 5148
Query: 452 PLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDG--SMQMESYDGTLRIVNVSREM 509
+ E D + L+C V G P+ + W + K++ +P SM E+ + RI +V ++
Sbjct: 5149 SVDVTEKDPMTLECVVAGTPELKVKWLKDGKQI-VPSRYFSMSFENNVASFRIQSVMKQD 5207
Query: 510 SGMYRCQTSQYNGFNVKPREALVQLIVQ-YPPAVEPAFLEIRQGQDRSVTMSCRVLRAYP 568
SG Y + N F +A ++++ Q PP+ ++ + S+ M C+V + P
Sbjct: 5208 SGQYTFKVE--NDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLP 5265
Query: 569 IRVLTYEWRLGNKLLRTGQ----FDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSF 624
I +W K + T + V +L E+ Y C + N AG CS
Sbjct: 5266 ISA---QWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSG 5322
Query: 625 LVTGK 629
++T K
Sbjct: 5323 ILTVK 5327
Score = 87.8 bits (216), Expect = 4e-17
Identities = 160/724 (22%), Positives = 275/724 (37%), Gaps = 117/724 (16%)
Query: 40 IEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNET-LRIT 98
IE + +V +R TL L + G P P+++W K G +DR Q + T L I
Sbjct: 25107 IELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLVID 25166
Query: 99 NIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLR 158
N+ R GRY EN GS K+ V+V LD P V+ +I E K+
Sbjct: 25167 NVTRFDSGRYNLTLENNSGS---KTAFVNVRVLDSPSAPVNLTIREVKKD---------S 25214
Query: 159 CVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIA 218
+ PP+ + +++ + + Y +++NL+ + +A
Sbjct: 25215 VTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLA 25274
Query: 219 SVRNVCNIPDKMVS-FRLSNKTASPSIKLLVD----------DPIVVNPGEAITLVCV-- 265
S +P + ++S P LVD + + G IT V
Sbjct: 25275 SNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEM 25334
Query: 266 -TTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVG--NPAKK 322
T G E + T V++ TI +T+ + + A N G +P +
Sbjct: 25335 QTKGSEKWSTCTQVKTL------------EATISGLTAGEEYVFRVAAVNEKGRSDPRQL 25382
Query: 323 STNIIVRALKKGRFWITPD---PYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRP 379
+I R ++ I P P+H N++ ++KI + P + T +W K+G+
Sbjct: 25383 GVPVIARDIE-----IKPSVELPFH-TFNVKAREQLKIDVPFKGRP--QATVNWRKDGQT 25434
Query: 380 LRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSST 439
L+ + R+ ++ S T+L I + D GTY S G I+ + I + +
Sbjct: 25435 LKETTRVNVSS-----SKTVTSLSIKEASKEDVGTYELCVSNSAGSIT-VPITIIVLDRP 25488
Query: 440 VPPN-LTVPQEKSPLVTREGDTIELQ--CQVTG-----KPKPIILWSRADKEVAMPDGSM 491
PP + + + +T + E CQ++ K W + VA
Sbjct: 25489 GPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVART---- 25544
Query: 492 QMESYDGTLRIVNVSREMSGMYR-CQTSQYNGFNVKPREALVQLIVQYP--PAVEPAFLE 548
+++IV ++ +R C ++Y + A+V +YP P P +
Sbjct: 25545 -------SIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVV---AEYPFSPPGPPGTPK 25594
Query: 549 IRQGQDRSVTMSCRV-LRAYPIRVLTYE----------WRLGNKLLRTGQFDSQEYTEYA 597
+ ++ ++ +V + RV+ Y W NK+L T+
Sbjct: 25595 VVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIAD-------TQMK 25647
Query: 598 VKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQ---NRHRVYSYS 654
V L Y N AG G+CS K+ P D +P Q S S
Sbjct: 25648 VSGLDEGLMYEYRVYAENIAGIGKCS-----KSCEPVPARDPCDPPGQPEVTNITRKSVS 25702
Query: 655 LQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKIN-GNIQKGELITYNLTELIKPEAY 713
L+W++ + D +I Y + R+ RW +K N NIQ+ + +TEL + + Y
Sbjct: 25703 LKWSKPHYDGGAKITGYIVERRELPDGRW----LKCNYTNIQE---TYFEVTELTEDQRY 25755
Query: 714 EVRL 717
E R+
Sbjct: 25756 EFRV 25759
Score = 87.4 bits (215), Expect = 6e-17
Identities = 143/630 (22%), Positives = 241/630 (38%), Gaps = 77/630 (12%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFN---ETLRITNIQRHQGGR 107
T++ G+ +++G P+P+I W K S F+ + + TL +
Sbjct: 3249 TVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAV 3308
Query: 108 YYCKAENGLG-SPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPP 166
Y C+A+N G + S+ V+V VV+ Q + T V + P
Sbjct: 3309 YTCEAKNDYGVATTSASLSVEV----PEVVSPDQEMPVYPPAII---TPLQDTVTSEGQP 3361
Query: 167 VRYSWR-RGQEVLLQGSDKGVEIYEPFF---TQGE-TKILKLKNLRPQDYANYSCIAS-- 219
R+ R G ++ + K +I F TQ E T L++ P+D Y+ +AS
Sbjct: 3362 ARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNA 3421
Query: 220 ---VRNVCNI----PDKMVSFRLSNK-----TASPSIKLLVDDPIVVNPGEAITLVCVTT 267
V + N+ P+ ++ R+ + A+P IK + +P+ V G C
Sbjct: 3422 VGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKI-EPLEVALGHLAKFTCEIQ 3480
Query: 268 GGEPAPSLTWVRSFGTLPE------KTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAK 321
P W ++ + E ++ +L I D G Y+C A+N G+ +
Sbjct: 3481 SA-PNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSC 3539
Query: 322 KSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLR 381
+T + A F P K +G+ K C V P E W K+G L
Sbjct: 3540 TATLTVTEAYPP-TFLSRP----KSLTTFVGKAAKFICTVTGTPVIETI--WQKDGAALS 3592
Query: 382 SSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVP 441
S I+ + L++ +L D G Y+C AS K G D+ + +
Sbjct: 3593 PSPNWRISDAE-----NKHILELSNLTIQDRGVYSCKASNKFGA------DICQAELIII 3641
Query: 442 PNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAM-PDGSMQMESYDGTL 500
+E P+ + + L+CQV K + WS+ +++ D + E TL
Sbjct: 3642 DKPHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATL 3701
Query: 501 RIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMS 560
I + SG Y C S G + V+ + V+P++L + S +
Sbjct: 3702 EIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLML---PGESARLH 3758
Query: 561 CRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKS--------LSNENYGVYNCS 612
C+ L+ P+ +T W NK L +S Y V S + E+ G Y+C
Sbjct: 3759 CK-LKGSPVIQVT--WFKNNKELS----ESNTVRMYFVNSEAILDITDVKVEDSGSYSCE 3811
Query: 613 IINEAGAGRCSFLVTGKAYAPEFYYDTYNP 642
+N+ G+ CS + K P + T P
Sbjct: 3812 AVNDVGSDSCSTEIVIK--EPPSFIKTLEP 3839
Score = 87.4 bits (215), Expect = 6e-17
Identities = 138/583 (23%), Positives = 223/583 (38%), Gaps = 66/583 (11%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGSA--SDRFQ-DSSVFNETLRITNIQRHQGGRYYCK 111
G + TC + P + +W K SD+ SS + +L I Q G Y CK
Sbjct: 3470 GHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCK 3529
Query: 112 AENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSW 171
A N GS + + + + S ++ F + F+ C P + W
Sbjct: 3530 ASNEYGSVSCTATLT----VTEAYPPTFLSRPKSLTTFVGKAAKFI-CTVTGTPVIETIW 3584
Query: 172 RRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVR---NVCN--- 225
++ L + + E IL+L NL QD YSC AS + ++C
Sbjct: 3585 QKDGAALSPSPNWRISDAE------NKHILELSNLTIQDRGVYSCKASNKFGADICQAEL 3638
Query: 226 -IPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL 284
I DK F + +I V V+ +T+ G + P + F
Sbjct: 3639 IIIDKP-HFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICF--- 3694
Query: 285 PEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH 344
E + TL IP D+GTY C A+N G+ + +T V + F DP +
Sbjct: 3695 -EDKI---ATLEIPLAKLKDSGTYVCTASNEAGSSSCSAT---VTVREPPSFVKKVDPSY 3747
Query: 345 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSE--RMVITQTDPDVSPGTTNL 402
+ G ++ C+++ P ++T WFKN + L S RM ++ L
Sbjct: 3748 L---MLPGESARLHCKLKGSPVIQVT--WFKNNKELSESNTVRMYFVNSE-------AIL 3795
Query: 403 DIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIE 462
DI D+K D G+Y+C A + G S ++ I PP+ E + +V G
Sbjct: 3796 DITDVKVEDSGSYSCEA-VNDVGSDSCSTEIVIKE---PPSFIKTLEPADIV--RGTNAL 3849
Query: 463 LQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDG--TLRIVNVSREMSGMYRCQTSQY 520
LQC+V+G I W + DK+ ++ S L I + + G Y C +
Sbjct: 3850 LQCEVSGTGPFEISWFK-DKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVAN- 3907
Query: 521 NGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGN 580
V + +++ PP ++ ++VT+ V + PI V W G
Sbjct: 3908 ---EVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAAVRGSEPISV---TWMKGQ 3961
Query: 581 KLLR-TGQFDSQEYTEYAVKSLSNENY---GVYNCSIINEAGA 619
+++R G+ AV + + G Y C NEAG+
Sbjct: 3962 EVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGS 4004
Score = 85.1 bits (209), Expect = 3e-16
Identities = 123/589 (20%), Positives = 228/589 (38%), Gaps = 89/589 (15%)
Query: 64 VTGHPRPQIRWTKTAGSASDRFQDSSVFNE------TLRITNIQRHQGGRYYCKAENGLG 117
V G P I W K + D +V+ TL+I ++ GRY C+A+N G
Sbjct: 5071 VAGSPPISITWLKDDQILDE---DDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESG 5127
Query: 118 SPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERT-VFLRCVANSNPPVRYSWRRGQE 176
V+ Y V Q + +AK E+ + L CV P ++ W + +
Sbjct: 5128 --------VERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGK 5179
Query: 177 VLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLS 236
++ Y + +++++ QD Y+ V N R+
Sbjct: 5180 QIVPSR------YFSMSFENNVASFRIQSVMKQDSGQYTF--KVENDFGSSSCDAYLRVL 5231
Query: 237 NKTASPSI--KLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN--- 291
++ PS KL D ++ G +I + C +G P S W + +
Sbjct: 5232 DQNIPPSFTKKLTKMDKVL---GSSIHMECKVSGSLPI-SAQWFKDGKEISTSAKYRLVC 5287
Query: 292 ---GGTLTIPAITSDDAGTYSCIANNNVGNPA-------KKSTNIIVRALKKGRFWITPD 341
+L + + +D Y+C +N G+ A K+ + +V K GR PD
Sbjct: 5288 HERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLV---KPGRQQAIPD 5344
Query: 342 PYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTN 401
V+ ++ P ++ WFK+ L S + I + T+
Sbjct: 5345 S-----------TVEFKAILKGTPPFKI--KWFKDDVELVSGPKCFI-----GLEGSTSF 5386
Query: 402 LDIIDLKFTDFGTYTCVASLKGGGISDISID--VNISSSTVPPNLTVPQEKSPLVTREGD 459
L++ + + G YTC + +D+ D + T PP E S +V + GD
Sbjct: 5387 LNLYSVDASKTGQYTCHVT------NDVGSDSCTTMLLVTEPPKFVKKLEASKIV-KAGD 5439
Query: 460 TIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYD--GTLRIVNVSREMSGMYRCQT 517
+ L+C++ G P+ ++W R + E+ D +M D +++ N+S E SG + C+
Sbjct: 5440 SSRLECKIAGSPEIRVVWFRNEHELPASD-KYRMTFIDSVAVIQMNNLSTEDSGDFICEA 5498
Query: 518 SQYNGFNVKPREALVQ---LIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTY 574
G + +V+ + +PP VE ++ V++ C + P V+ Y
Sbjct: 5499 QNPAGSTSCSTKVIVKEPPVFSSFPPIVETL-------KNAEVSLECELSGTPPFEVVWY 5551
Query: 575 EWRLGNKLLRTGQFDSQEY-TEYAVKSLSNENYGVYNCSIINEAGAGRC 622
+ + + + + S+ + T + ++ + G Y+C NE G+ C
Sbjct: 5552 KDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTC 5600
Score = 84.3 bits (207), Expect = 5e-16
Identities = 115/500 (23%), Positives = 205/500 (41%), Gaps = 71/500 (14%)
Query: 153 RTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYA 212
+TV L+ + P+ +W +GQEV+ + + F+ G +L + +++
Sbjct: 3939 QTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMS-----FSNG-VAVLIIPDVQISFGG 3992
Query: 213 NYSCIASVRNVCNIPDKMVSFRLSNKTASPSI--KLLVDDP---------IVVNPGEAIT 261
Y+C+A N+ S + +L+V +P I V G+ T
Sbjct: 3993 KYTCLAE-----------------NEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPAT 4035
Query: 262 LVCVTTGGEPAPSLTWVRSFGTLPEKTVL------NGGTLTIPAITSDDAGTYSCIANNN 315
L T G P W + L N L + D+G Y+ +N
Sbjct: 4036 LE-YTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNE 4094
Query: 316 VGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFK 375
VG+ + ++T + L + P D++ G ++ C++ S + SWFK
Sbjct: 4095 VGSSSCETTFTV---LDRDIAPFFTKPLRNVDSVVNGT-CRLDCKIAG--SLPMRVSWFK 4148
Query: 376 NGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNI 435
+G+ + +S+R I + GT +L+II + D G +TC A+ G D S + +
Sbjct: 4149 DGKEIAASDRYRIAFVE-----GTASLEIIRVDMNDAGNFTCRAT-NSVGSKDSSGALIV 4202
Query: 436 SSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQM-- 493
P +T P K L G + L+ G I W + +KE+ + GS +
Sbjct: 4203 QEP--PSFVTKPGSKDVL---PGSAVCLKSTFQGSTPLTIRWFKGNKEL-VSGGSCYITK 4256
Query: 494 ESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQ 553
E+ + +L + V SG Y C+ S G V+ + +EP+ L +++G
Sbjct: 4257 EALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQL-LKKGD 4315
Query: 554 DRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEY-AVKSLSN---ENYGVY 609
+ ++C+V PI++ W ++ ++ + E AV L++ E+ G Y
Sbjct: 4316 --ATQLACKVTGTPPIKIT---WFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEY 4370
Query: 610 NCSIINEAGAGRCSFLVTGK 629
C NEAG+ CS +V K
Sbjct: 4371 MCEAQNEAGSDHCSSIVIVK 4390
Score = 81.6 bits (200), Expect = 3e-15
Identities = 131/596 (21%), Positives = 227/596 (38%), Gaps = 74/596 (12%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGSA--SDRFQDSSVFNET-LRITNIQRHQGGRYYCK 111
GE+ + C VTG +I W+K + + V N LRI + + G+Y C+
Sbjct: 6285 GESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQ 6344
Query: 112 AENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSW 171
A N +G S ++ V +P V + EA + ++ L C + +P ++ SW
Sbjct: 6345 ATNDVGKDMC-SAQLSV---KEPPKFVKKL--EASKVAKQGESIQLECKISGSPEIKVSW 6398
Query: 172 RRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMV 231
R L + + +L + +D +Y C A + D
Sbjct: 6399 FRNDSELHESWKYNMSFIN------SVALLTINEASAEDSGDYICEAHN----GVGDASC 6448
Query: 232 SFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN 291
S L+ K +P + P+ G + L C +G P + WV+ K V N
Sbjct: 6449 STALTVK--APPVFTQKPSPVGALKGSDVILQCEISGTPPF-EVVWVKD-----RKQVRN 6500
Query: 292 GGTLTIPA-----------ITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITP 340
I + + + D G Y C A N VG+ + + V+ + RF
Sbjct: 6501 SKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSD---TCSCSVKFKEPPRFV--- 6554
Query: 341 DPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKN-GRPLRSSERMVITQTDPDVSPGT 399
D + IG V++ VE + ++ W K+ G +R SE I+ D
Sbjct: 6555 -KKLSDTSTLIGDAVELRAIVEGF--QPISVVWLKDRGEVIRESENTRISFID-----NI 6606
Query: 400 TNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGD 459
L + + ++ G Y C G+ + S + TV + ++ P+ G+
Sbjct: 6607 ATLQLGSPEASNSGKYICQIK-NDAGMRECSAVL-----TVLEPARIIEKPEPMTVTTGN 6660
Query: 460 TIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMS--GMYRCQT 517
L+C VTG P+ W + +E++ D + + + EMS G+Y +
Sbjct: 6661 PFALECVVTGTPELSAKWFKDGRELS-ADSKHHITFINKVASLKIPCAEMSDKGLYSFEV 6719
Query: 518 SQYNGFNVKPREALVQLIVQ---YPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTY 574
+V V + V PP+ ++ SV + CRV + PI V +
Sbjct: 6720 KN----SVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWF 6775
Query: 575 EWRLGNKLLRTGQFDSQEYTEYAVKSLS---NENYGVYNCSIINEAGAGRCSFLVT 627
+ GN+++ + S +LS + G+Y C N AG+ CS ++T
Sbjct: 6776 Q--DGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLT 6829
Score = 77.4 bits (189), Expect = 6e-14
Identities = 120/598 (20%), Positives = 221/598 (36%), Gaps = 70/598 (11%)
Query: 49 VYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNE---TLRITNIQRHQG 105
V +R G++ C +TG P+ ++ W + + F + T +I+ +
Sbjct: 4870 VLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENS 4929
Query: 106 GRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNP 165
G Y C+A N G+ S +++ + P T + + + Y + V L C P
Sbjct: 4930 GTYVCEARNDAGT---ASCSIELKVKEPP--TFIRELKPVEVVKYSD--VELECEVTGTP 4982
Query: 166 PVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVR-NVC 224
P +W + + + F L + P D Y CI S C
Sbjct: 4983 PFEVTWLKNNREIRSSKKYTLTDRVSVFN------LHITKCDPSDTGEYQCIVSNEGGSC 5036
Query: 225 NIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL 284
+ S R++ K IK + + V+ T G P S+TW++ L
Sbjct: 5037 S-----CSTRVALKEPPSFIKKIENTTTVLKSSATFQ---STVAGSPPISITWLKDDQIL 5088
Query: 285 PE------KTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWI 338
E V + TL I ++ + +G Y+C A N G + ++ +
Sbjct: 5089 DEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAK 5148
Query: 339 TPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPG 398
+ D KD + + C V P EL W K+G+ + S ++
Sbjct: 5149 SVDVTEKD-------PMTLECVVAGTP--ELKVKWLKDGKQIVPSRYFSMS-----FENN 5194
Query: 399 TTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREG 458
+ I + D G YT G S + + +PP+ T K V G
Sbjct: 5195 VASFRIQSVMKQDSGQYTFKVE-NDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVL--G 5251
Query: 459 DTIELQCQVTGKPKPIILWSRADKEVA-MPDGSMQMESYDGTLRIVNVSREMSGMYRCQT 517
+I ++C+V+G W + KE++ + +L + N+ E + Y C+
Sbjct: 5252 SSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKV 5311
Query: 518 SQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAY-----PIRVL 572
S NV +A ++ P P+FL ++ G+ +++ S +A P ++
Sbjct: 5312 S-----NVAGDDACSGILTVKEP---PSFL-VKPGRQQAIPDSTVEFKAILKGTPPFKI- 5361
Query: 573 TYEWRLGNKLLRTGQ---FDSQEYTEYA-VKSLSNENYGVYNCSIINEAGAGRCSFLV 626
+W + L +G + T + + S+ G Y C + N+ G+ C+ ++
Sbjct: 5362 --KWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTML 5417
Score = 77.4 bits (189), Expect = 6e-14
Identities = 122/599 (20%), Positives = 227/599 (37%), Gaps = 84/599 (14%)
Query: 57 TLELTCLVTGHPRPQIRWTKT---AGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAE 113
T+E ++ G P +I+W K S F L + ++ + G+Y C
Sbjct: 5346 TVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVT 5405
Query: 114 NGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRR 173
N +GS + ++ + + +P V + EA + + L C +P +R W R
Sbjct: 5406 NDVGSDSCTTMLL----VTEPPKFVKKL--EASKIVKAGDSSRLECKIAGSPEIRVVWFR 5459
Query: 174 GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSF 233
+ L SDK Y F ++++ NL +D ++ C A +N
Sbjct: 5460 NEHEL-PASDK----YRMTFIDS-VAVIQMNNLSTEDSGDFICEA--QNPAG-------- 5503
Query: 234 RLSNKTASPSIKLLVDDPIVVNP---------GEAITLVCVTTGGEPAPSLTWVRSFGTL 284
+ S S K++V +P V + ++L C +G P + W + L
Sbjct: 5504 -----STSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPF-EVVWYKDKRQL 5557
Query: 285 PEKTVLNGGT------LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWI 338
+ + I + + D G Y C A N VG+ T V+ + RF
Sbjct: 5558 RSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCT---VKLKEPPRFVS 5614
Query: 339 TPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRP-LRSSERMVITQTDPDVSP 397
+ + G ++ +E ++ + W K +R SE + IT +
Sbjct: 5615 KLNSL----TVVAGEPAELQASIEG--AQPIFVQWLKEKEEVIRESENIRITFVE----- 5663
Query: 398 GTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTRE 457
L + + G Y C GG + N+++ V + ++ P+
Sbjct: 5664 NVATLQFAKAEPANAGKYICQIKNDGG------MRENMATLMVLEPAVIVEKAGPMTVTV 5717
Query: 458 GDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYD--GTLRIVNVSREMSGMYRC 515
G+T L+C+V G P+ + W + D ++ + Y+ +LRI++V R+ +G Y
Sbjct: 5718 GETCTLECKVAGTPELSVEWYK-DGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTF 5776
Query: 516 QTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQ----DRSVTMSCRVLRAYPIRV 571
Q G + + ++ AV P+F + S + C+V + PI V
Sbjct: 5777 QVQNNVG-----KSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISV 5831
Query: 572 LTYEWRLGNKLLRTGQFD---SQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 627
+ + K++ ++ S + SL + + G Y C N AG+ C ++T
Sbjct: 5832 AWFHEK--TKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLT 5888
Score = 63.5 bits (153), Expect = 9e-10
Identities = 100/457 (21%), Positives = 172/457 (37%), Gaps = 86/457 (18%)
Query: 20 GQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAG 79
G+ P TV+ A ++ + + +R G + + G P P+I W++ G
Sbjct: 24004 GEATSVPGTVKPEDKLEAPELDLDSELRKGIVVRAGGSARIHIPFKGRPTPEITWSREEG 24063
Query: 80 SASDRFQDSSVFNET-LRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTV 138
+D+ Q N T L I N R+ G+Y K EN GS KS V V LD P
Sbjct: 24064 EFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGS---KSAFVTVKVLDTPGPPQ 24120
Query: 139 HQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGET 198
+ ++ E ++ + FL PP+ + + ++ + + Y ++
Sbjct: 24121 NLAVKEVRKD-----SAFLVW----EPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSK 24171
Query: 199 KILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGE 258
K++NL + +A +P + V + + SP PG+
Sbjct: 24172 TSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSP-------------PGK 24218
Query: 259 AITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIP-AITSDDAGT--YSCIANNN 315
V +T + + SL W EK +GG+ + + GT +S +A +
Sbjct: 24219 ----VTLTDVSQTSASLMW--------EKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESK 24266
Query: 316 VGNPAKKSTNIIVRALKKGRFW--------------------------ITPDPYHK---- 345
V N +V L G+ + +T P K
Sbjct: 24267 V-------CNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFN 24319
Query: 346 DDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDII 405
+IQ G ++KI V P + SW K+G PL+ + R+ + +T +T L I
Sbjct: 24320 TYSIQAGEDLKIEIPVIGRPRPNI--SWVKDGEPLKQTTRVNVEET-----ATSTVLHIK 24372
Query: 406 DLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPP 442
+ DFG YT A+ G ++ ++ V + PP
Sbjct: 24373 EGNKDDFGKYTVTATNSAGTATE-NLSVIVLEKPGPP 24408
Score = 59.3 bits (142), Expect = 2e-08
Identities = 97/437 (22%), Positives = 165/437 (37%), Gaps = 66/437 (15%)
Query: 20 GQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAG 79
G+ P + + A +I+ + ++ IR G +L L + G P P+++W K G
Sbjct: 22922 GEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDG 22981
Query: 80 SASD-RFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTV 138
D D + +L + N+ R+ G+Y EN G+ KS V V LD P V
Sbjct: 22982 EIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGT---KSAFVTVRVLDTPSPPV 23038
Query: 139 HQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGET 198
+ + E + PP+ + + +++ + + Y T
Sbjct: 23039 NLKVTEITKD---------SVSITWEPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHK 23089
Query: 199 KILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGE 258
K+ L Q+ +Y + N I L +TA P V P PG+
Sbjct: 23090 NSWKIDQL--QEGCSYYFRVTAENEYGI-------GLPAQTADPIKVAEVPQP----PGK 23136
Query: 259 AITLVCVTTGGEPAPSLTWVRSFGTLPEKTV-------------------LNGGTLTIPA 299
IT+ VT + SL+W + K + + I
Sbjct: 23137 -ITVDDVTRN---SVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSLQAVITN 23192
Query: 300 ITSDDAGTYSCIANNNVG--NPAKKSTNIIVRALKKGRFWITPD--PYHKDDNIQIGREV 355
+T + + +A N G +P + I+ + L I PD P ++Q+G+++
Sbjct: 23193 LTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLV-----IEPDVKPAFSSYSVQVGQDL 23247
Query: 356 KISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTY 415
KI + P T +W K+G PL+ + R+ +T S T L I + D G Y
Sbjct: 23248 KIEVPISGRPKP--TITWTKDGLPLKQTTRINVTD-----SLDLTTLSIKETHKDDGGQY 23300
Query: 416 -TCVASLKGGGISDISI 431
VA++ G + I I
Sbjct: 23301 GITVANVVGQKTASIEI 23317
Score = 58.9 bits (141), Expect = 2e-08
Identities = 129/600 (21%), Positives = 222/600 (37%), Gaps = 81/600 (13%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTK-----TAGSASDRFQDSSVFNETLRITNIQRHQG 105
T+ + TG PRP WTK T G +D F L I
Sbjct: 32862 TVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGF--FLEIHKTDTSDS 32919
Query: 106 GRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNP 165
G Y C +N GS + S ++ + + D T Q + K E T + V
Sbjct: 32920 GLYTCTVKNSAGSVS-SSCKLTIKAIKD---TEAQKVSTQKTS---EITPQKKAVV---- 32968
Query: 166 PVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILK---LKNLRPQDYANYSCIASVRN 222
QE + Q + + EI E LK K L ++ + + ++
Sbjct: 32969 ---------QEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKS 33019
Query: 223 VCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFG 282
+ + S IK + +N G+ + L G A + WV +
Sbjct: 33020 IVHEEITKTSQASEEVRTHAEIKAF-STQMSINEGQRLVLKANIAG---ATDVKWVLNGV 33075
Query: 283 TLPEKTVLNGG------TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRF 336
L G TLTI + D G +CI+ G + + + L
Sbjct: 33076 ELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPA 33135
Query: 337 WITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVS 396
+I+ + NI G+ V +C++ PS E+ WFKN P+ S + I++ S
Sbjct: 33136 FISQP---RSQNINEGQNVLFTCEISGEPSPEI--EWFKNNLPISISSNVSISR-----S 33185
Query: 397 PGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTR 456
+L+I + +D G YT A G S +S V P + P + L T
Sbjct: 33186 RNVYSLEIRNASVSDSGKYTIKAKNFRGQCS------ATASLMVLPLVEEPSREVVLRT- 33238
Query: 457 EGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVS-REMSGM--- 512
GDT LQ + + + S + +E + S S ++ ++S + MS M
Sbjct: 33239 SGDT-SLQGSFSSQS---VQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQES 33294
Query: 513 -YRCQTSQYNGF-NVKPREALVQLIVQ-----YPPAVEPAFLEIRQGQDRSVTMSCRVLR 565
+S + G N+ E+ +++ PP +E +I + + +T++C
Sbjct: 33295 FVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVAC-AFT 33353
Query: 566 AYPIRVLTYEWRLGNKLLRT---GQF---DSQEYTEYAVKSLSNENYGVYNCSIINEAGA 619
P +T W G + + + G+F ++ + T + + ++ G+Y S+ NE G+
Sbjct: 33354 GEPTPEVT--WSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGS 33411
Score = 56.2 bits (134), Expect = 1e-07
Identities = 88/425 (20%), Positives = 160/425 (37%), Gaps = 45/425 (10%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGS--ASDRFQDSSVFNET-LRITNIQRHQGGRYYCK 111
GE+ + C VTG ++ W K + + ++Q S + N L + + + G+Y C
Sbjct: 8167 GESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCY 8226
Query: 112 AENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSW 171
A N +G + + L P T + + E E+ VA S P + +W
Sbjct: 8227 AVNEVGKDSCTAQLNIKERLIPPSFT--KRLSETVEETEGNSFKLEGRVAGSQP-ITVAW 8283
Query: 172 RRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMV 231
+ + S+ + + T +L+++ D Y+C S + +
Sbjct: 8284 YKNNIEIQPTSNCEITF------KNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSI 8337
Query: 232 SFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN 291
+ K P + P+ V+ GE + L C G EP + W+++ + +
Sbjct: 8338 VIKEPKK---PPVFDQHLTPVTVSEGEYVQLSCHVQGSEPI-RIQWLKAGREIKPSDRCS 8393
Query: 292 ----GGT--LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIV----------RALKKGR 335
GT L + + D+G Y C A+N G+ KS I +A GR
Sbjct: 8394 FSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGR 8453
Query: 336 FWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNG-RPLRSSERMVITQTDPD 394
+ +P +I++ + + + W K R L R+ I Q +
Sbjct: 8454 LFFVSEP----QSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDE 8509
Query: 395 VSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS---DISIDVNISSSTVPPNLTVPQEKS 451
L+I D TD G Y CVA + G I ++ +D + +L +K+
Sbjct: 8510 AK-----LEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDERKKQEKIEGDLRAMLKKT 8564
Query: 452 PLVTR 456
P++ +
Sbjct: 8565 PILKK 8569
Score = 55.8 bits (133), Expect = 2e-07
Identities = 142/738 (19%), Positives = 252/738 (34%), Gaps = 92/738 (12%)
Query: 50 YTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQ---DSSVFNETLRITNIQRHQGG 106
Y+++ G+ L++ ++G P+P I WTK + S+ TL I + GG
Sbjct: 23239 YSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGG 23298
Query: 107 RYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPP 166
+Y N +G K+ +++ LD P K ++ + NPP
Sbjct: 23299 QYGITVANVVGQ---KTASIEIVTLDKP--------DPPKGPVKFDDVSAESITLSWNPP 23347
Query: 167 VRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVR---NV 223
+ + ++Q D +++ LK+ L+ + A R +
Sbjct: 23348 LYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSF 23407
Query: 224 CNIPDKMVS---FRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRS 280
D +V+ ++ +P + D +V+ E V GG P R
Sbjct: 23408 ALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEP-----VNNGGSPVIGYHLERK 23462
Query: 281 -----FGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGR 335
T KT+++ + + A N VG + +A K
Sbjct: 23463 ERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVG---------VGKASKNSE 23513
Query: 336 FWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMV----ITQT 391
++ DP + + V E+T W K P+ M+ + +
Sbjct: 23514 CYVARDPCDPPG----------TPEPIMVKRNEITLQWTK---PVYDGGSMITGYIVEKR 23560
Query: 392 D-PD---VSPGTTNLDIIDLKFTDFGT-------YTCVASLKGGGIS---DISIDVNISS 437
D PD + TN +I+ +FT G + +A G IS D + +
Sbjct: 23561 DLPDGRWMKASFTN--VIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKD 23618
Query: 438 STVPPNLTV-PQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV-AMPDGSMQMES 495
P +++ P+ + +V G+T L+ V GKP P I W R DKE+ ++
Sbjct: 23619 EVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTD 23678
Query: 496 YDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDR 555
+ L + + R G Y + S G P V+++ + P P + +
Sbjct: 23679 FKALLIVKDAIRIDGGQYILRASNVAGSKSFP--VNVKVLDRPGPPEGPVQVTGVTSEKC 23736
Query: 556 SVTMSCRVL-RAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSII 614
S+T S + I E R ++L T V L N V+ +
Sbjct: 23737 SLTWSPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAV 23796
Query: 615 NEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLG 674
N+ G G P + S ++ W + + D I+ Y +
Sbjct: 23797 NKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVE 23856
Query: 675 IRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIK 734
R RW I N ++ + +T L + YE R++ G G+ + +
Sbjct: 23857 KRDRSGIRW------IKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVY 23910
Query: 735 YSA---------PVNPHL 743
Y A P N H+
Sbjct: 23911 YKACDPVFKPGPPTNAHI 23928
Score = 55.8 bits (133), Expect = 2e-07
Identities = 48/199 (24%), Positives = 89/199 (44%), Gaps = 19/199 (9%)
Query: 429 ISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKE-VAMP 487
+SI ++S P + +E + T+ G+ +L CQ+ G+P P I W R KE +
Sbjct: 30521 MSIKTKLTSGEAPG---IRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSR 30577
Query: 488 DGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFL 547
M + TL ++ +E G+Y C + V E +L++Q P P +
Sbjct: 30578 KYKMSSDGRTHTLTVMTEEQEDEGVYTCIATN----EVGEVETSSKLLLQATPQFHPGY- 30632
Query: 548 EIRQGQDRSVTMSCRVLRAY---PIRVLTYEWRLGNKLLRTGQ----FDSQEYTEYAVKS 600
+++ +V + R+ Y P+ +T W G KLL+ + +++ YT +K+
Sbjct: 30633 PLKEKYYGAVGSTLRLHVMYIGRPVPAMT--WFHGQKLLQNSENITIENTEHYTHLVMKN 30690
Query: 601 LSNENY-GVYNCSIINEAG 618
+ + + G Y + N G
Sbjct: 30691 VQRKTHAGKYKVQLSNVFG 30709
Score = 55.8 bits (133), Expect = 2e-07
Identities = 83/391 (21%), Positives = 136/391 (34%), Gaps = 108/391 (27%)
Query: 235 LSNKTASPSIKLLVDDPIVVNP-------GEAITLVCVTTGGEPAPSLTWVRSFGTLPEK 287
L K+ + IK + I+ P GE+ C T GEP P++TW+R L
Sbjct: 32546 LEEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSC-DTDGEPVPTVTWLRKGQVLSTS 32604
Query: 288 ------TVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRA----------- 330
T T I ++ + D G YS + N+ G + T I +A
Sbjct: 32605 ARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPP 32664
Query: 331 --------------LKKGRFWITPDPYH---------------KDDNIQIGREVKISCQV 361
+K + +P+P H K ++ + KI+ +
Sbjct: 32665 RVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFL 32724
Query: 362 EAVPSEELT---------------FSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 406
+A S+E+ +W+K+G+ L+ + + + GT L I +
Sbjct: 32725 KAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYS----ADGTYELKINN 32780
Query: 407 LKFTDFGTYTCVASLKGG------------------GISDIS----IDVNISSSTV---- 440
L +D G Y C S +GG +S IS D + STV
Sbjct: 32781 LTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKT 32840
Query: 441 PPNLTVPQEKSPLV-------TREGDTI-ELQCQVTGKPKPIILWSRADKEVAMPDGSMQ 492
P P P++ T D++ + + TG+P+P +W++ K +
Sbjct: 32841 EPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKL 32900
Query: 493 MESYDG-TLRIVNVSREMSGMYRCQTSQYNG 522
E G L I SG+Y C G
Sbjct: 32901 SEDKGGFFLEIHKTDTSDSGLYTCTVKNSAG 32931
Score = 55.1 bits (131), Expect = 3e-07
Identities = 40/120 (33%), Positives = 56/120 (46%), Gaps = 5/120 (4%)
Query: 16 EGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWT 75
EG+ G+ P T + L IE + +V TIR TL L + G P P+++W
Sbjct: 21837 EGL-GEPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWA 21895
Query: 76 KTAGSASDRFQDSSVFNETLRIT-NIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDP 134
+ G + D+ S + TL I N+ R G+Y EN GS KS V+V LD P
Sbjct: 21896 RDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSGS---KSAFVNVRVLDTP 21952
Score = 54.7 bits (130), Expect = 4e-07
Identities = 46/183 (25%), Positives = 76/183 (41%), Gaps = 9/183 (4%)
Query: 352 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 411
G + P E+ SWF++G+ + +S + S G L I + +
Sbjct: 20 GSTATFEAHISGFPVPEV--SWFRDGQVISTS---TLPGVQISFSDGRAKLTIPAVTKAN 74
Query: 412 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKP 471
G Y+ A+ G G + + ++ + + T PPN Q + R+G + LQ +VTG P
Sbjct: 75 SGRYSLKAT-NGSGQATSTAELLVKAETAPPNFV--QRLQSMTVRQGSQVRLQVRVTGIP 131
Query: 472 KPIILWSRADKEV-AMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREA 530
P++ + R E+ + D + E +L I E SG Y + G E
Sbjct: 132 TPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAEL 191
Query: 531 LVQ 533
LVQ
Sbjct: 192 LVQ 194
Score = 53.5 bits (127), Expect = 9e-07
Identities = 64/285 (22%), Positives = 114/285 (40%), Gaps = 46/285 (16%)
Query: 295 LTIPAITSDDAGTYSCIANNNVGNPAK--KSTNIIVRALKKGRFWITPDPYHKDDNIQIG 352
L IP+ DAG Y+ +A NV + ++ +R++KK +Q+
Sbjct: 3114 LLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIKK--------------EVQVI 3159
Query: 353 REVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDF 412
+ + + E V +++ W+K+G + V + V + I + + +D
Sbjct: 3160 EKQRAVVEFE-VNEDDVDAHWYKDGIEINFQ---VQERHKYVVERRIHRMFISETRQSDA 3215
Query: 413 GTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPK 472
G YT VA G S +++ VN PP V QE P+ + G ++G+P+
Sbjct: 3216 GEYTFVA---GRNRSSVTLYVNAPE---PPQ--VLQELQPVTVQSGKPARFCAVISGRPQ 3267
Query: 473 PIILWSRADKEVAMPDGSMQMESYDG---TLRIVNVSREMSGMYRCQTSQYNGFNVKPRE 529
P I W + +E + G +DG TL ++ E + +Y C+ N + V
Sbjct: 3268 PKISWYK--EEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAK--NDYGVATTS 3323
Query: 530 ALVQLIVQ-----------YPPAVEPAFLEIRQGQDRSVTMSCRV 563
A + + V YPPA+ + + + CRV
Sbjct: 3324 ASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRV 3368
Score = 52.4 bits (124), Expect = 2e-06
Identities = 110/530 (20%), Positives = 202/530 (38%), Gaps = 90/530 (16%)
Query: 34 SGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGS--ASDRFQDSS-V 90
SG A I +E + T + GE +L+C + G P P I+W + S +++ SS
Sbjct: 30529 SGEAPGIRKEM---KDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDG 30585
Query: 91 FNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFY 150
TL + ++ G Y C A N +G + L H KE++Y
Sbjct: 30586 RTHTLTVMTEEQEDEGVYTCIATNEVG-----EVETSSKLLLQATPQFHPGY-PLKEKYY 30639
Query: 151 --YERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRP 208
T+ L + P +W GQ++L + +E E + L +KN++
Sbjct: 30640 GAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHY------THLVMKNVQR 30693
Query: 209 QDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTG 268
+ +A + + NV D ++ + +K P+ PIV+ EA+
Sbjct: 30694 KTHAGKYKV-QLSNVFGTVDAILDVEIQDKPDKPT------GPIVI---EALLKNSAVIS 30743
Query: 269 GEPA--PSLTWVRSFGTLPEKTVLNGGT---LTIPAIT---------SDDAGTYSCIANN 314
+P +W+ ++ + EK G L AI+ +++AG Y ++
Sbjct: 30744 WKPPADDGGSWITNY--VVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQ 30801
Query: 315 N---VGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTF 371
N + +P + S+ +I+++ P+ K G K + + AV +
Sbjct: 30802 NTFGISDPLEVSSVVIIKS-----------PFEKP-----GAPGKPT--ITAVTKDSCVV 30843
Query: 372 SWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKG-------- 423
+W + R + ++ +++ T F + L+
Sbjct: 30844 AWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCEN 30903
Query: 424 -GGISDISIDVNISSSTVPPNLTVP-------QEKSPLVTREGDTIELQCQVTGKPKPII 475
GG S+ S S + P VP +E L R L C+VTG PKPI+
Sbjct: 30904 LGGESEWS----EISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIV 30959
Query: 476 LWSRADKEVAMPDGSMQMESYDG---TLRIVNVSREMSGMYRCQTSQYNG 522
W R KE+ +++ + G L I +V+ + + +Y+ + + G
Sbjct: 30960 KWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGG 31009
Score = 50.8 bits (120), Expect = 6e-06
Identities = 75/313 (23%), Positives = 121/313 (38%), Gaps = 35/313 (11%)
Query: 418 VASLKGGGISDISIDVNISSSTVPPNLTVPQE------KSPLVTREGDTIELQCQVTGKP 471
V+++ G G D S +V + V LT P+ K V R G +I L G+P
Sbjct: 28328 VSAINGAGKGD-SCEVTGTIKAVD-RLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRP 28385
Query: 472 KPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREAL 531
P +WS+ D +++ +S+ TL + N +R +G Y +G K
Sbjct: 28386 TPTAVWSKPDSNLSLRADIHTTDSF-STLTVENCNRNDAGKYTLTVENNSG--SKSITFT 28442
Query: 532 VQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQ 591
V+++ P F ++ +G + M L R+ Y R+ Q S+
Sbjct: 28443 VKVLDTPGPPGPITFKDVTRGS--ATLMWDAPLLDGGARIHHYVVEKREASRRSWQVISE 28500
Query: 592 EYTE--YAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHR 649
+ T + V L+ + S +NE G G PE T P R
Sbjct: 28501 KCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGE-------PYEMPEPIVATEQPAPPRRLD 28553
Query: 650 VYSYS-----LQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNL 704
V S L W + + D RI Y L +RQ G W E G+ ++ +T+ +
Sbjct: 28554 VVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEA-----GHTKQ---LTFTV 28605
Query: 705 TELIKPEAYEVRL 717
L++ YE R+
Sbjct: 28606 ERLVEKTEYEFRV 28618
Score = 50.1 bits (118), Expect = 1e-05
Identities = 67/309 (21%), Positives = 123/309 (39%), Gaps = 51/309 (16%)
Query: 48 RVYTIREGETLELTCLVTGHPRPQIRWTKT--AGSASDRFQDSSVFN-ETLRITNIQRHQ 104
R I EG+ + TC ++G P P+I W K S S S N +L I N
Sbjct: 33141 RSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSD 33200
Query: 105 GGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSN 164
G+Y KA+N G + + + + +++P R V LR +++
Sbjct: 33201 SGKYTIKAKNFRGQCSATASLMVLPLVEEP-----------------SREVVLRTSGDTS 33243
Query: 165 PPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLK--------------NLRPQD 210
+S Q V + S K + F + + + ++K +
Sbjct: 33244 LQGSFS---SQSVQMSAS-KQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMS 33299
Query: 211 YANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGE 270
+++ I+++ + + KM+ + + P I+ L D I ++ G+ +T+ C T GE
Sbjct: 33300 SSSFMGISNMTQLESSTSKML--KAGIRGIPPKIEALPSD-ISIDEGKVLTVACAFT-GE 33355
Query: 271 PAPSLTW--------VRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKK 322
P P +TW + G + + TL I + D G Y+ N G+ +
Sbjct: 33356 PTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDS-A 33414
Query: 323 STNIIVRAL 331
+ NI +R++
Sbjct: 33415 TVNIHIRSI 33423
Score = 47.0 bits (110), Expect = 9e-05
Identities = 31/103 (30%), Positives = 47/103 (45%), Gaps = 6/103 (5%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQ---DSSVFNETLRITNIQRHQGGRY 108
+R G T+ L V G P P+I W+K + DR S+ F+ LR N+ ++ G+Y
Sbjct: 19705 LRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKY 19764
Query: 109 YCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYY 151
EN G K + V LD P V+ ++ E + Y
Sbjct: 19765 ILTLENSCGK---KEYTIVVKVLDTPGPPVNVTVKEISKDSAY 19804
Score = 47.0 bits (110), Expect = 9e-05
Identities = 76/327 (23%), Positives = 123/327 (37%), Gaps = 52/327 (15%)
Query: 440 VPPNLTV-PQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYD- 497
VPP + P+ L+ + G+++ ++ V G+P P + W + E+ + M ME D
Sbjct: 27954 VPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEI---EKRMNMEITDV 28010
Query: 498 ---GTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPP--AVEPAFLEIRQG 552
+L + + +R+ G+Y + +G +A +++ VQ P V P G
Sbjct: 28011 LGSTSLFVRDATRDHRGVYTVEAKNASG----SAKAEIKVKVQDTPGKVVGPIRFTNITG 28066
Query: 553 Q------DRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENY 606
+ D + C + Y I E R ++L D E Y L N N
Sbjct: 28067 EKMTLWWDAPLNDGCAPITHYII-----EKRETSRLAWALIEDKCEAQSYTAIKLINGNE 28121
Query: 607 GVYNCSIINEAGAGR----------CSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQ 656
+ S +N+ G GR + V PE T N S +L
Sbjct: 28122 YQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGN----------SITLT 28171
Query: 657 WTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVR 716
W + D I Y L R+ RW +K+ E + +T L + YE
Sbjct: 28172 WARPESDGGSEIQQYILERREKKSTRW----VKVISKRPISE-TRFKVTGLTEGNEYEFH 28226
Query: 717 LTPLTKFGEGDST--IRVIKYSAPVNP 741
+ G G ++ R+IK PVNP
Sbjct: 28227 VMAENAAGVGPASGISRLIKCREPVNP 28253
Score = 45.4 bits (106), Expect = 2e-04
Identities = 30/101 (29%), Positives = 45/101 (44%), Gaps = 4/101 (3%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQ-DSSVFNETLRITNIQRHQGGRYYC 110
I+ G+TL L+ ++ G P P++ W K A + + D + L I N GG Y
Sbjct: 17230 IKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSL 17289
Query: 111 KAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYY 151
EN GS K++ V V LD P + E ++ Y
Sbjct: 17290 TVENPAGS---KTVSVKVLVLDKPGPPRDLEVSEIRKDSCY 17327
Score = 45.1 bits (105), Expect = 3e-04
Identities = 79/399 (19%), Positives = 151/399 (37%), Gaps = 53/399 (13%)
Query: 349 IQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLK 408
++ G ++++ V P ++T W K L+ +R+ I P + + I+D K
Sbjct: 13702 VKAGTKIELPATVTGKPEPKIT--WTKADMILKQDKRITIENV-----PKKSTVTIVDSK 13754
Query: 409 FTDFGTYTCVASLKGGGISDISIDVNISSSTVPP---NLTVPQEKSPLVTREGDTIELQC 465
+D GTY + ++ G + ++VN+ PP ++T +S L+T +
Sbjct: 13755 RSDTGTYI-IEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGS 13813
Query: 466 QVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNV 525
++T ++ D EV + D + + ++R G
Sbjct: 13814 KITNY---VVERRATDSEVWH---KLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGE 13867
Query: 526 KPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMS-CRV-------LRAYPIRVL---TY 574
+ + + Q+ P P LE +VT++ C + Y + L T
Sbjct: 13868 PVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTD 13927
Query: 575 EWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPE 634
+W NK+ + T Y VK L+N+ + N AG G+ S K+ P
Sbjct: 13928 KWVRCNKM-------PVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPS-----KSTEPI 13975
Query: 635 FYYDTYNPVWQNRHRVY------SYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEI 688
D +P W S L WT+ D +I +Y + + + G W +
Sbjct: 13976 LIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEW----V 14031
Query: 689 KINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGD 727
++ + + + L L++ + Y R+ + K GE +
Sbjct: 14032 RVAEGVPTTQ---HLLPGLMEGQEYSFRVRAVNKAGESE 14067
Score = 44.7 bits (104), Expect = 4e-04
Identities = 105/550 (19%), Positives = 194/550 (35%), Gaps = 148/550 (26%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF---NETLRITNIQRHQGGR 107
T+ EGE ++L+C V G +I+W K + S F L + ++ + G
Sbjct: 8356 TVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGD 8415
Query: 108 YYCKAENGLGS----------------PAIKSIRVD--VYYLDDPV-------------- 135
Y CKA N GS PA K VD ++++ +P
Sbjct: 8416 YVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIA 8475
Query: 136 -------------------------VTVHQSIGEAKEQFYYERTV---FLRCVA------ 161
V +HQ EAK + RCVA
Sbjct: 8476 KVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGE 8535
Query: 162 -NSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQG-----ETKILKL-KNLRPQDYANY 214
SN ++ R+ QE + +G + + P +G E I++L KN+ P++Y Y
Sbjct: 8536 IESNVNLQVDERKKQEKI-EGDLRAMLKKTPILKKGAGEEEEIDIMELLKNVDPKEYEKY 8594
Query: 215 SCIASVRNVCNIP--------------------------------DKMVSFRLSNKTASP 242
+ + + + + +++VSF + +
Sbjct: 8595 ARMYGITDFRGLLQAFELLKQSQEEETHRLEIEEIERSERDEKEFEELVSFIQQRLSQTE 8654
Query: 243 SIKLL--VDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPE----KTVLNGG--T 294
+ L+ +++ V+ +A+ + + P L+W + L + ++G T
Sbjct: 8655 PVTLIKDIENQTVLKDNDAVFEIDIKIN-YPEIKLSWYKGTEKLEPSDKFEISIDGDRHT 8713
Query: 295 LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGRE 354
L + D G Y + ++ A +I A ++ + +D ++ G+
Sbjct: 8714 LRVKNCQLKDQGNYRLVCGPHI---ASAKLTVIEPAWER---------HLQDVTLKEGQT 8761
Query: 355 VKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGT 414
++CQ +VP+ + WF+NGR L+ R +V L I D++ D G
Sbjct: 8762 CTMTCQF-SVPN--VKSEWFRNGRILKPQGR-----HKTEVEHKVHKLTIADVRAEDQGQ 8813
Query: 415 YTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPI 474
YTC D+ + P T + +V E + +C+V+ I
Sbjct: 8814 YTC-------KYEDLETSAELRIEAEPIQFT--KRIQNIVVSEHQSATFECEVS-FDDAI 8863
Query: 475 ILWSRADKEV 484
+ W + E+
Sbjct: 8864 VTWYKGPTEL 8873
Score = 44.7 bits (104), Expect = 4e-04
Identities = 35/124 (28%), Positives = 55/124 (44%), Gaps = 7/124 (5%)
Query: 15 LEGISGQGVYAP---PTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQ 71
+ I+ GV P P V IV +A + E + R +R G ++ + + G P P+
Sbjct: 20748 ISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPE 20807
Query: 72 IRWTKTAGSASDRFQDSSVFNETLR-ITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYY 130
+ WTK + +R + + TL I R+ G++ EN G KS V+V
Sbjct: 20808 VTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGK---KSGFVNVRV 20864
Query: 131 LDDP 134
LD P
Sbjct: 20865 LDTP 20868
Score = 44.3 bits (103), Expect = 6e-04
Identities = 72/309 (23%), Positives = 126/309 (40%), Gaps = 72/309 (23%)
Query: 295 LTIPAITSDDAGTYSCIA-------NNNVGNP----AKKSTNIIVRALKKGRFWITPDPY 343
L I T +D TY+C A N NV P + T++ VR + RF
Sbjct: 12341 LVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTDLQVREKEMARF------- 12393
Query: 344 HKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLD 403
C++ E WFK+G ++ ++ I +S G +
Sbjct: 12394 --------------ECELSR---ENAKVKWFKDGAEIKKGKKYDI------ISKGAVRIL 12430
Query: 404 IID-LKFTDFGTYTC-VASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTI 461
+I+ D Y+C V + + G+ + + + + + N+ V E DTI
Sbjct: 12431 VINKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLA-NIEVS---------ETDTI 12480
Query: 462 ELQCQVTGKPKPIILWSRADKEVAMPDGSMQM--ESYDGTLRIVNVSREMSGMYRCQ--T 517
+L C+V+ KP ++W + D+E+ + G ++ E L I N E +G Y C+ +
Sbjct: 12481 KLVCEVS-KPGAEVIWYKGDEEI-IETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPS 12538
Query: 518 SQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWR 577
S+ +G VK E + I +P LEI +G+ S ++P+ +W+
Sbjct: 12539 SRTDG-KVKVHELAAEFI------SKPQNLEILEGEKAEFVCSIS-KESFPV-----QWK 12585
Query: 578 LGNKLLRTG 586
+K L +G
Sbjct: 12586 RDDKTLESG 12594
Score = 43.9 bits (102), Expect = 7e-04
Identities = 29/93 (31%), Positives = 45/93 (48%), Gaps = 2/93 (2%)
Query: 47 ERVYTIREGETLELTCLVTGHPRPQIRWTKTA-GSASDRFQDSSVFNETLRITNIQRHQG 105
++ TIR G +L L V+G P P I W+K AS D++ L + + R+
Sbjct: 29453 KKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDA 29512
Query: 106 GRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTV 138
G+Y +AEN G + ++ V VY P +V
Sbjct: 29513 GKYTIEAENQSGKKS-ATVLVKVYDTPGPCPSV 29544
Score = 43.1 bits (100), Expect = 0.001
Identities = 135/674 (20%), Positives = 241/674 (35%), Gaps = 87/674 (12%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRIT------NIQRHQ 104
TIR GE LT +G P+P++ W K +D +D +T T +R
Sbjct: 16829 TIRVGEAFALTGRYSGKPKPKVSWFK---DEADVLEDDRTHIKTTPATLALEKIKAKRSD 16885
Query: 105 GGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQ-SIGEAKEQFYYERTVFLRCVANS 163
G+Y EN GS + V +D P V S E + + V +
Sbjct: 16886 SGKYCVVVENSTGS---RKGFCQVNVVDRPGPPVGPVSFDEVTKDY---------MVISW 16933
Query: 164 NPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNV 223
PP+ + +++ + G +++ P + K+ L + +Y N+
Sbjct: 16934 KPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKL--LEGKDYIFRIHAENL 16991
Query: 224 CNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVT---TGGEPAPSL----- 275
I D +VS + K + D PIV + LV GG+P +
Sbjct: 16992 YGISDPLVSDSMKAKDRF-RVPDAPDQPIVTEVTKDSALVTWNKPHDGGKPITNYILEKR 17050
Query: 276 -TWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANN--NVGNPAKKSTNIIVR-AL 331
T + + + + + +P + + A N +G+P+ S + + +
Sbjct: 17051 ETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFAKDPI 17110
Query: 332 KKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQT 391
K + P+ N V ++ Q + + + E T
Sbjct: 17111 AKPSPPVNPEAIDTTCN-----SVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHT 17165
Query: 392 DPDVSPGTTNLDIIDLKFTDFGTYTC-VASLKGGGISD---ISIDVNISSSTVPPNLTVP 447
P+ P T + L+ D TY V ++ G SD + V + PP L +
Sbjct: 17166 -PESCP-ETKYKVTGLR--DGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILD 17221
Query: 448 QEKS-PLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVS 506
+ + GDT+ L + G P P + W + D++ A + + L I N +
Sbjct: 17222 ANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRD-APTKARIDVTPVGSKLEIRNAA 17280
Query: 507 REMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCR---- 562
E G+Y G + V+++V P P LE+ + + S ++ +
Sbjct: 17281 HEDGGIYSLTVENPAG----SKTVSVKVLVLDKPG-PPRDLEVSEIRKDSCYLTWKEPLD 17335
Query: 563 ----VLRAYPIR---VLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIIN 615
V+ Y + V + +W + L T + S + K L+ N ++ + N
Sbjct: 17336 DGGSVITNYVVERRDVASAQW---SPLSATSKKKS-----HFAKHLNEGNQYLFRVAAEN 17387
Query: 616 EAGAGRCSFLVTGKAYAPEFYYDTYNPVW--QNRHRV----YSYSLQWTQMNPDAVDRIV 669
+ G G F+ T K P D +P ++ H V SL W + + D I
Sbjct: 17388 QYGRG--PFVETPK---PIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPIT 17442
Query: 670 AYRLGIRQAGQQRW 683
Y + ++ G Q W
Sbjct: 17443 GYLVEYQEEGTQDW 17456
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 4/108 (3%)
Query: 28 TVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQD 87
T++ V A ++ + ++ + +R G ++ L G P P W+K + S R
Sbjct: 28345 TIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADI 28404
Query: 88 SSVFN-ETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDP 134
+ + TL + N R+ G+Y EN GS KSI V LD P
Sbjct: 28405 HTTDSFSTLTVENCNRNDAGKYTLTVENNSGS---KSITFTVKVLDTP 28449
Score = 42.4 bits (98), Expect = 0.002
Identities = 81/370 (21%), Positives = 141/370 (38%), Gaps = 55/370 (14%)
Query: 154 TVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYAN 213
T+ L C S P W +G E +++ YE T+G +IL ++N +D N
Sbjct: 12479 TIKLVCEV-SKPGAEVIWYKGDEEIIETGR-----YE-ILTEGRKRILVIQNAHLEDAGN 12531
Query: 214 YSCIASVRNVCNIPDKMVSFRLSNKTASPSIKL-LVDDP--IVVNPGEAITLVCVTTGGE 270
Y+C ++ S R K + + P + + GE VC + E
Sbjct: 12532 YNC------------RLPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVC-SISKE 12578
Query: 271 PAPSLTWVRSFGTL---PEKTVLNGG---TLTIPAITSDDAGTYSCIANNNVGNPAKKST 324
P + W R TL + V+ G L + T D GTY + A+ +
Sbjct: 12579 SFP-VQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMV-----GAARAAA 12632
Query: 325 NIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSE 384
++ V ++K R + KD ++ +EV +C+V +E WF+N + S
Sbjct: 12633 HLTV--IEKLRIVVP----LKDTRVKEQQEVVFNCEVN---TEGAKAKWFRNEEAIFDSS 12683
Query: 385 RMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNL 444
+ +I Q D L I D D Y SL ++ N+ +L
Sbjct: 12684 KYIILQKDL-----VYTLRIRDAHLDDQANYN--VSLTNHRGENVKSAANL--IVEEEDL 12734
Query: 445 TVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDG-SMQMESYDGTLRIV 503
+ + + T E ++ C+V + + W++ +EV + S +++ Y L I
Sbjct: 12735 RIVEPLKDIETMEKKSVTFWCKV-NRLNVTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIK 12793
Query: 504 NVSREMSGMY 513
+ G Y
Sbjct: 12794 DCGFPDEGEY 12803
Score = 42.4 bits (98), Expect = 0.002
Identities = 32/97 (32%), Positives = 46/97 (47%), Gaps = 3/97 (3%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSA-SDRFQDSSVFNET-LRITNIQRHQGGRYY 109
I G+TL + +VTG P P WTK G DR +V ++ L I + R GRY
Sbjct: 15116 IMAGKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYV 15175
Query: 110 CKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAK 146
A N GS + RV+V+ + PV+ + + K
Sbjct: 15176 ITATNSCGS-KFAAARVEVFDVPGPVLDLKPVVTNRK 15211
Score = 42.4 bits (98), Expect = 0.002
Identities = 41/173 (23%), Positives = 79/173 (45%), Gaps = 13/173 (7%)
Query: 164 NPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNV 223
+PP++ + +++ ++G E +E + E + KL ++ A Y N+
Sbjct: 16442 SPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDK-EVRGTKLVVTGLKEGAFYKFRVRAVNI 16500
Query: 224 CNI--PDKMVS-FRLSNKTASPSIKL--LVDDPIVVNPGEAITLVCVTTGGEPAPSLTWV 278
I P ++ + ++ SP ++L V D IVV+ G I ++ +G +P P++TW
Sbjct: 16501 AGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSG-KPPPTVTWN 16559
Query: 279 RSFGTLPEKTVLN----GGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNII 327
+ TLP++ + ++ I G YS +A N G +K T I+
Sbjct: 16560 MNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGE--RKKTIIV 16610
Score = 42.4 bits (98), Expect = 0.002
Identities = 26/79 (32%), Positives = 37/79 (46%), Gaps = 13/79 (16%)
Query: 49 VYTIREGETLELTCLVTGHPRPQIRWTKTAGSAS---------DRFQDSSVFNETLRITN 99
V T++ G+T+ L V G P P++ WTK + D DSS F+ +T
Sbjct: 18210 VLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFS----LTK 18265
Query: 100 IQRHQGGRYYCKAENGLGS 118
+R GG+Y A N GS
Sbjct: 18266 AKRSDGGKYVVTATNTAGS 18284
Score = 42.4 bits (98), Expect = 0.002
Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 3/99 (3%)
Query: 427 SDISIDVNISSSTVPPNLTV-PQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVA 485
SD S + PN ++ P+ K +V G+T L+ + GKP P ++WS+ KE+
Sbjct: 24690 SDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGKELE 24749
Query: 486 MPDGSMQMES--YDGTLRIVNVSREMSGMYRCQTSQYNG 522
M+++S TL + + R G Y + S G
Sbjct: 24750 ETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGG 24788
Score = 42.4 bits (98), Expect = 0.002
Identities = 32/107 (29%), Positives = 47/107 (43%), Gaps = 3/107 (2%)
Query: 17 GISGQGVYAPPTVRIVHSGLACNIE-EERYSERVYTIREGETLELTCLVTGHPRPQIRWT 75
G G+ P TV++ + E +ERY E ++ +R+G + LT + G P P +WT
Sbjct: 30113 GGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIF-VRQGGVIRLTIPIKGKPFPICKWT 30171
Query: 76 KTAGSASDRFQDSSVFNET-LRITNIQRHQGGRYYCKAENGLGSPAI 121
K S R ++ T L I R G Y EN G A+
Sbjct: 30172 KEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENKCGKKAV 30218
Score = 41.2 bits (95), Expect = 0.005
Identities = 68/342 (19%), Positives = 131/342 (38%), Gaps = 62/342 (18%)
Query: 294 TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHK---DDNIQ 350
TLT+ + +DAG A + K N+ V+ P + K D ++
Sbjct: 12251 TLTLRDVKLEDAGEVQLTAKD-----FKTHANLFVKE--------PPVEFTKPLEDQTVE 12297
Query: 351 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPG-TTNLDIIDLKF 409
G + C+V E WFKNG + S++ I V+ G L I D
Sbjct: 12298 EGATAVLECEVSR---ENAKVKWFKNGTEILKSKKYEI------VADGRVRKLVIHDCTP 12348
Query: 410 TDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTG 469
D TYTC A D N+ + VPP++ + + L RE + +C+++
Sbjct: 12349 EDIKTYTCDA-------KDFKTSCNL--NVVPPHVEFLRPLTDLQVREKEMARFECELS- 12398
Query: 470 KPKPIILWSRADKEVAMPDGSMQMESYD----GTLRIVNVSR---EMSGMYRCQTSQYNG 522
+ + W + E+ + + YD G +RI+ +++ + Y C+
Sbjct: 12399 RENAKVKWFKDGAEI------KKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVR---- 12448
Query: 523 FNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKL 582
R + + +++ I + ++ + C V + V+ Y+ ++
Sbjct: 12449 ---TARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKP-GAEVIWYKG--DEEI 12502
Query: 583 LRTGQFDSQEYTEYAVKSLSN---ENYGVYNCSIINEAGAGR 621
+ TG+++ + + N E+ G YNC + + G+
Sbjct: 12503 IETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGK 12544
Score = 41.2 bits (95), Expect = 0.005
Identities = 79/368 (21%), Positives = 142/368 (38%), Gaps = 69/368 (18%)
Query: 403 DIIDLKFT-----DFGTYTC-VASLKGGGISDISIDV---NISSSTVPPNLTVPQEKSPL 453
D+ +L+FT + G Y V ++ G+S S V + +PP++ + K +
Sbjct: 16070 DVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDL---KEFM 16126
Query: 454 VTREGDTIELQCQVTGKPKPIILWSRA------DKEVAMPDGSMQMESYDGTLRIV--NV 505
EG + + ++ G P P + W +A +KE + D + D T +V
Sbjct: 16127 EVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQS 16186
Query: 506 SREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLR 565
R +G+Y + N +E + ++ + P V P E SV+ L
Sbjct: 16187 RRSDTGLY--TITAVNNLGTASKEMRLNVLGRPGPPVGPIKFE-------SVSADQMTLS 16237
Query: 566 AYP--------IRVLTYEWRLGNKLLRTGQFDSQE-----YT--------EYAVKSLSNE 604
+P I E R N+ +T S E YT EY + ++
Sbjct: 16238 WFPPKDDGGSKITNYVIEKREANR--KTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQN 16295
Query: 605 NYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDA 664
YG+ + +E R F V G P T + V +N S ++ W + D
Sbjct: 16296 KYGIGE-PLDSEPETARNLFSVPGAPDKP-----TVSSVTRN-----SMTVNWEEPEYDG 16344
Query: 665 VDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGEL--ITYNLTELIKPEAYEVRLTPLTK 722
+ Y L ++ +RW ++N + K ++Y +T LI+ Y+ R+ +
Sbjct: 16345 GSPVTGYWLEMKDTTSKRW----KRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINA 16400
Query: 723 FGEGDSTI 730
G G +++
Sbjct: 16401 AGVGPASL 16408
Score = 41.2 bits (95), Expect = 0.005
Identities = 36/127 (28%), Positives = 58/127 (45%), Gaps = 7/127 (5%)
Query: 427 SDISIDVNISSSTVPPNLTVPQE-KSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVA 485
S+ S V I + VPP + + KS L + G + L V GKP P + W + +
Sbjct: 19278 SEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLK 19337
Query: 486 MPDG-SMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEP 544
+G M M+ TL + +V+R+ SG Y +G + A ++L V P P
Sbjct: 19338 PAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSG----SKSATIKLKVLDKPG-PP 19392
Query: 545 AFLEIRQ 551
A ++I +
Sbjct: 19393 ASVKINK 19399
Score = 40.8 bits (94), Expect = 0.006
Identities = 50/205 (24%), Positives = 84/205 (40%), Gaps = 15/205 (7%)
Query: 438 STVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVA---MPDGSMQME 494
+T P T P + +V EG T + ++G P P + W R + ++ +P +
Sbjct: 2 TTQAPTFTQPLQS--VVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFS 59
Query: 495 SYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEP-AFLEIRQGQ 553
L I V++ SG Y + + +G E LV+ P V+ + +RQG
Sbjct: 60 DGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGS 119
Query: 554 DRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFD-SQEYTEYA--VKSLSNENYGVYN 610
V + RV P V+ + +R G ++ + F SQE Y+ + E+ G Y+
Sbjct: 120 --QVRLQVRV-TGIPTPVVKF-YRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYS 175
Query: 611 CSIINEAG--AGRCSFLVTGKAYAP 633
+ N G LV G+ P
Sbjct: 176 VNATNSVGRATSTAELLVQGEEEVP 200
Score = 40.8 bits (94), Expect = 0.006
Identities = 42/160 (26%), Positives = 73/160 (45%), Gaps = 19/160 (11%)
Query: 269 GEPAPSLTWVR-----SFGTLPEKTVL---NGGTLTIPAITSDDAGTYSCIANNNVGNPA 320
G P P ++W R S TLP + LTIPA+T ++G YS A N G A
Sbjct: 31 GFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQ-A 89
Query: 321 KKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPL 380
+ ++V+A ++ + ++ G +V++ +V +P+ + F +++G +
Sbjct: 90 TSTAELLVKAETAPPNFV---QRLQSMTVRQGSQVRLQVRVTGIPTPVVKF--YRDGAEI 144
Query: 381 RSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVAS 420
+SS I+Q S L I + D GTY+ A+
Sbjct: 145 QSSLDFQISQEGDLYS-----LLIAEAYPEDSGTYSVNAT 179
Score = 40.8 bits (94), Expect = 0.006
Identities = 34/137 (24%), Positives = 66/137 (48%), Gaps = 10/137 (7%)
Query: 352 GREVKISCQVEAVPSEELTFSWFKNGRPLRSS-ERMVITQTDPDVSPGTTNLDIIDLKFT 410
G+ + +V P E TF WF +G+ + + V+ + D GT +L I+ +
Sbjct: 1471 GQTARFDLKVVGRPMPE-TF-WFHDGQQIVNDYTHKVVIKED-----GTQSLIIVPATPS 1523
Query: 411 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGK 470
D G +T VA + G S IS+ + + + ++ + +EG +E++ + TG
Sbjct: 1524 DSGEWTVVAQNRAGR-SSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGN 1582
Query: 471 PKPIILWSRADKEVAMP 487
P P I+W + + ++ +P
Sbjct: 1583 PNPDIVWLK-NSDIIVP 1598
Score = 40.8 bits (94), Expect = 0.006
Identities = 26/85 (30%), Positives = 40/85 (47%), Gaps = 5/85 (5%)
Query: 53 REGETLELTCLVTGHPRPQIRWTK---TAGSASDRFQDSSVFNETLRITNIQRHQGGRYY 109
+ GE +++ G P P + W K GS + +++ + L I + R+ G+Y
Sbjct: 27284 KAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYI 27343
Query: 110 CKAENGLGSPAIKSIRVDVYYLDDP 134
ENG+G P KS V V LD P
Sbjct: 27344 LTIENGVGEP--KSSTVSVKVLDTP 27366
Score = 40.4 bits (93), Expect = 0.008
Identities = 71/331 (21%), Positives = 122/331 (36%), Gaps = 31/331 (9%)
Query: 425 GISDISIDVNISSSTVPPNLTVPQE-------KSPLVTREGDTIELQCQVTGKPKPIILW 477
G SD S ++ P ++ +P E + L+ R G T+ L V G+P P I W
Sbjct: 19671 GYSDPS---DVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITW 19727
Query: 478 SRADKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIV 536
S+ + + G ++ +D LR NV++ +G Y N K +V+++
Sbjct: 19728 SKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLE--NSCGKKEYTIVVKVLD 19785
Query: 537 QYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEY 596
P V EI + + PI + R + + T +
Sbjct: 19786 TPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTSF 19845
Query: 597 AVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVY---SY 653
V +L + NE G G G+ T PV + R S
Sbjct: 19846 RVANLEEGKSYFFRVFAENEYGIGD-----PGETRDAVKASQTPGPVVDLKVRSVSKSSC 19900
Query: 654 SLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAY 713
S+ W + + D RI+ Y + ++ W++ + K + Y+ +L + + Y
Sbjct: 19901 SIGWKKPHSDGGSRIIGYVVDF--LTEENKWQR-------VMKSLSLQYSAKDLTEGKEY 19951
Query: 714 EVRLTPLTKFGEG-DSTIRVIKYSAPVNPHL 743
R++ + GEG S I V+ V P L
Sbjct: 19952 TFRVSAENENGEGTPSEITVVARDDVVAPDL 19982
Score = 40.4 bits (93), Expect = 0.008
Identities = 61/333 (18%), Positives = 116/333 (34%), Gaps = 48/333 (14%)
Query: 236 SNKTASPSIKLLVDDPIVVNPGEAITL--------------VCVTTGGEPAPSLTWVRSF 281
+ KT+ ++L P ++ ITL + +P + W +
Sbjct: 32352 TQKTSERKYEVLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNG 32411
Query: 282 GTLPEKTVLN----GGTLTIPAIT--SDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGR 335
L E + ++ G LT+ + +DD+GTY + N G + +T + G
Sbjct: 32412 VELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVT-----GG 32466
Query: 336 FWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDV 395
+ T +D+ EV S E +E S FK + +S + + +
Sbjct: 32467 DYTTYASQRRDE------EVPRSVFPELTRTEAYAVSSFKKTSEMEASSS--VREVKSQM 32518
Query: 396 SPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSP--L 453
+ +L + ++ A +K + + S++ ++ + L P +
Sbjct: 32519 TETRESLSSYE--------HSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSM 32570
Query: 454 VTREGDTIELQCQVTGKPKPIILWSRADKEVA-MPDGSMQMESYDGTLRIVNVSREMSGM 512
EG++ C G+P P + W R + ++ + Y T I +V G
Sbjct: 32571 TVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGN 32630
Query: 513 YRCQTSQYNGFNVKPREALVQLIVQYPPAVEPA 545
Y G +EA L +Q E A
Sbjct: 32631 YSVVVENSEG----KQEAEFTLTIQKARVTEKA 32659
Score = 40.0 bits (92), Expect = 0.010
Identities = 29/128 (22%), Positives = 54/128 (42%), Gaps = 5/128 (3%)
Query: 400 TNLDIIDLKFTDFGTYTC---VASLKGGGISDISIDVNISSSTVPPNLTVPQEK-SPLVT 455
TNL+ + TY ++ G G+ D +I + VPP++ + + LV
Sbjct: 17463 TNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVV 17522
Query: 456 REGDTIELQCQVTGKPKPIILWSRADKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMYR 514
+ G T+ + G P P W+ E+ + +++ +++ L I N R +G Y+
Sbjct: 17523 KAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQ 17582
Query: 515 CQTSQYNG 522
S G
Sbjct: 17583 ITVSNAAG 17590
Score = 40.0 bits (92), Expect = 0.010
Identities = 26/86 (30%), Positives = 42/86 (48%), Gaps = 9/86 (10%)
Query: 252 IVVNPGEAITLVCVTTGGEPAPSLTW---VRSFGTLPEKTVLN---GGTLTIPAITSDDA 305
++ GE + V + G P P++TW ++ G+ ++ N LTIP +T +D
Sbjct: 27281 VIAKAGEDVQ-VLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDT 27339
Query: 306 GTYSCIANNNVGNPAKKSTNIIVRAL 331
G Y N VG P KS+ + V+ L
Sbjct: 27340 GKYILTIENGVGEP--KSSTVSVKVL 27363
Score = 39.7 bits (91), Expect = 0.014
Identities = 70/345 (20%), Positives = 126/345 (36%), Gaps = 44/345 (12%)
Query: 345 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDI 404
+D + + SCQ+ E+ W++NGR ++ ++ + D + L I
Sbjct: 12830 EDQTVTEFDDAVFSCQLSR---EKANVKWYRNGREIKEGKKYKF-EKDGSIH----RLII 12881
Query: 405 IDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQ 464
D + D Y C G+ D + +P + P + ++ G +
Sbjct: 12882 KDCRLDDECEYAC-------GVEDRKSRARLFVEEIPVEIIRPPQ--DILEAPGADVVFL 12932
Query: 465 CQVTGKPKPIILWSRADKEVAMPD-GSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGF 523
++ K K + W R + V D M E L+I ++ G YR F
Sbjct: 12933 AEL-NKDKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYR--------F 12983
Query: 524 NVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL 583
K +EA +L + P ++ A ++ + +TM AYP EW N+ L
Sbjct: 12984 IAKDKEARAKLELAAAPKIKTADQDLVVDVGKPLTMVV-PYDAYP--KAEAEWFKENEPL 13040
Query: 584 RTGQFD-SQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNP 642
T D + E T + + + G Y + N+ G + + D P
Sbjct: 13041 STKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHG--------KAEGFINLKVIDVPGP 13092
Query: 643 VWQNRHRVYSY----SLQWTQMNPDAVDRIVAYRLGIRQAGQQRW 683
V +N ++ SL W + D +I+ Y + R ++ W
Sbjct: 13093 V-RNLEVTETFDGEVSLAWEEPLTDGGSKIIGYVVERRDIKRKTW 13136
Score = 39.7 bits (91), Expect = 0.014
Identities = 28/120 (23%), Positives = 50/120 (41%), Gaps = 3/120 (2%)
Query: 2 DLLYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELT 61
DL G + V E +G+G + TV +A +++ + + Y +E L
Sbjct: 19944 DLTEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLK 20003
Query: 62 CLVTGHPRPQIRWTKTAGSASDRFQ---DSSVFNETLRITNIQRHQGGRYYCKAENGLGS 118
+ G P P + W K + + +SS N TL + + Q+ G+Y +N G+
Sbjct: 20004 IPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGT 20063
Score = 39.3 bits (90), Expect = 0.018
Identities = 72/323 (22%), Positives = 118/323 (36%), Gaps = 45/323 (13%)
Query: 447 PQEKSPLVTREGDTIELQC-QVTGKPKPIILWSRADKEVAMPDGSMQMES--YDGTLRIV 503
P K L + GDTI L + GKP P WS+A K++ P Q+ S L I
Sbjct: 20382 PTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDI-RPSDITQITSTPTSSMLTIK 20440
Query: 504 NVSREMSGMYRCQTSQYNGFNVKPREALVQLI-VQYPPAVEPAFLEIRQGQDRSVTMSCR 562
+R+ +G Y + N F K V ++ V PP P + + ++T +
Sbjct: 20441 YATRKDAGEYTITAT--NPFGTKVEHVKVTVLDVPGPPG--PVEISNVSAEKATLTWTPP 20496
Query: 563 VL-RAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGR 621
+ PI+ E R ++LL T + + + L N ++ S +N G G
Sbjct: 20497 LEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGE 20556
Query: 622 ----------CSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAY 671
F G PE T N + ++ W + D I Y
Sbjct: 20557 PVQSEPVKMVDRFGPPGPPEKPEVSNVTKN----------TATVSWKRPVDDGGSEITGY 20606
Query: 672 RLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEG---DS 728
+ R+ RW + + +T L + YE R++ + G G ++
Sbjct: 20607 HVERREKKSLRW------VRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEA 20660
Query: 729 TIRVIKYSA------PVNPHLRE 745
+ V+ A P NPH+ +
Sbjct: 20661 SDSVLMKDAAYPPGPPSNPHVTD 20683
Score = 39.3 bits (90), Expect = 0.018
Identities = 54/248 (21%), Positives = 87/248 (35%), Gaps = 33/248 (13%)
Query: 450 KSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT------LRIV 503
+ L+ + G + + G+P P +LWS+ PD ++ +Y T L I
Sbjct: 26193 RKTLIVKAGASFTMTVPFRGRPVPNVLWSK-------PDTDLRTRAYVDTTDSRTSLTIE 26245
Query: 504 NVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRV 563
N +R SG Y NV +L ++ P + ++ S +S V
Sbjct: 26246 NANRNDSGKYTLTIQ-----NVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDV 26300
Query: 564 LR---AYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAG 620
P++ E R +K ++ Y V +L + S NE G G
Sbjct: 26301 PENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVG 26360
Query: 621 -----RCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGI 675
+ +T K PE + S SL W + D RIV Y +
Sbjct: 26361 IPAETKEGVKITEKPSPPE-------KLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEA 26413
Query: 676 RQAGQQRW 683
+ GQ+ W
Sbjct: 26414 LEKGQKNW 26421
Score = 38.9 bits (89), Expect = 0.023
Identities = 90/420 (21%), Positives = 152/420 (36%), Gaps = 57/420 (13%)
Query: 440 VPPNLTVPQEKSPLVT-REGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDG 498
+PP + + + +VT R T+ L + G+P P + W+R D ++ S++ S
Sbjct: 21856 LPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWAR-DHGESLDKASIESTSSYT 21914
Query: 499 TLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVT 558
L + NV+R SG Y +G + A V + V P P L++++ SVT
Sbjct: 21915 LLIVGNVNRFDSGKYILTVENSSG----SKSAFVNVRVLDTPG-PPQDLKVKEVTKTSVT 21969
Query: 559 MSC--------RVLRAYPIRV-----LTYEWRLGNKLLRTGQFDS-QEYTEYAVKSLSNE 604
++ ++ Y + Y N + + D QE Y + L+
Sbjct: 21970 LTWDPPLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAEN 22029
Query: 605 NYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDA 664
YG+ + E+ L GK T V +N S SL W + D
Sbjct: 22030 EYGIGLPAETAESVKASERPLPPGKI--------TLMDVTRN-----SVSLSWEKPEHDG 22076
Query: 665 VDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFG 724
RI+ Y + ++ G +W ++ +T LI+ E Y R++ + G
Sbjct: 22077 GSRILGYIVEMQTKGSDKW--------ATCATVKVTEATITGLIQGEEYSFRVSAQNEKG 22128
Query: 725 EGDS---TIRVIKYSAPVNPHLREFHCGF-----EDGNICL-FTQDDTDNFDWTK----- 770
D ++ VI + P + F ED + + F T W K
Sbjct: 22129 ISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPL 22188
Query: 771 QSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGP 830
+ T N + T N + +E Y+ GE L+ + P P GP
Sbjct: 22189 KQTTRVNAESTENNSLLTIKDACREDVGHYV-VKLTNSAGEAIETLNVIVLDKPGPPTGP 22247
Score = 38.9 bits (89), Expect = 0.023
Identities = 38/153 (24%), Positives = 68/153 (44%), Gaps = 8/153 (5%)
Query: 410 TDFGTYTCVASLKG-GGISDISIDVNISSSTVPPNLTVPQE-KSPLVTREGDTIELQCQV 467
T++ C + +G G + + V PP + + + + +V R T+ L +
Sbjct: 25072 TEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTI 25131
Query: 468 TGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKP 527
G+P+P + W +A+ + +++ S L I NV+R SG Y +G
Sbjct: 25132 KGRPEPEVKWEKAE-GILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSG----S 25186
Query: 528 REALVQLIVQYPPAVEPAFLEIRQGQDRSVTMS 560
+ A V + V P+ P L IR+ + SVT+S
Sbjct: 25187 KTAFVNVRVLDSPSA-PVNLTIREVKKDSVTLS 25218
Score = 38.9 bits (89), Expect = 0.023
Identities = 63/291 (21%), Positives = 107/291 (36%), Gaps = 37/291 (12%)
Query: 453 LVT-REGDTIELQCQVTGKPKPIILWSRADKEVAMPDG-SMQMESYDGTLRIVNVSREMS 510
LVT R G + L V GKP+P I+W++ DKE+ + + S+Q T I R S
Sbjct: 29056 LVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDS 29115
Query: 511 GMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIR 570
G Y +G K +V+++ P + + Q + + I
Sbjct: 29116 GKYTLTVKNASG--TKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEIT 29173
Query: 571 VLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAG---------- 620
E R ++L Y V L N ++ +N+ G G
Sbjct: 29174 HYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVA 29233
Query: 621 RCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQ 680
R SF + PE V + + +QWT+ D + I Y + R+
Sbjct: 29234 RNSFTIPSPPGIPE-------EVGTGKEHII---IQWTKPESDGGNEISNYLVDKREKKS 29283
Query: 681 QRWWEQEIKINGNIQKGELITYN----LTELIKPEAYEVRLTPLTKFGEGD 727
RW ++N + + Y+ +T L++ Y+ R+T + G +
Sbjct: 29284 LRW----TRVN-----KDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSE 29325
Score = 38.5 bits (88), Expect = 0.030
Identities = 23/87 (26%), Positives = 41/87 (47%), Gaps = 8/87 (9%)
Query: 437 SSTVPPNLTVPQEKSPLVTR-------EGDTIELQCQVTGKPKPIILWSRADKEV-AMPD 488
++ VP + +P LV+ EG+++ L+C ++G P P + W R D ++ + D
Sbjct: 929 TARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSID 988
Query: 489 GSMQMESYDGTLRIVNVSREMSGMYRC 515
+ +S L I E SG + C
Sbjct: 989 FQITFQSGIARLMIREAFAEDSGRFTC 1015
Score = 38.5 bits (88), Expect = 0.030
Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 3/63 (4%)
Query: 453 LVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESY--DGTLRIVNVSREMS 510
L + G IEL VTGKP+P I W++AD + D + +E+ T+ IV+ R +
Sbjct: 13700 LTVKAGTKIELPATVTGKPEPKITWTKADM-ILKQDKRITIENVPKKSTVTIVDSKRSDT 13758
Query: 511 GMY 513
G Y
Sbjct: 13759 GTY 13761
Score = 38.5 bits (88), Expect = 0.030
Identities = 38/124 (30%), Positives = 51/124 (41%), Gaps = 24/124 (19%)
Query: 252 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGT--------LTIPAITSD 303
++V G I L + G PAP +TW R G + V G L IP T D
Sbjct: 18616 VIVRAGCPIRLFAIVRG-RPAPKVTW-RKVGI--DNVVRKGQVDLVDTMAFLVIPNSTRD 18671
Query: 304 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEA 363
D+G YS N G +K+ + VR L TP P ++++ K SC V
Sbjct: 18672 DSGKYSLTLVNPAG---EKAVFVNVRVLD------TPGPV---SDLKVSDVTKTSCHVSW 18719
Query: 364 VPSE 367
P E
Sbjct: 18720 APPE 18723
Score = 38.5 bits (88), Expect = 0.030
Identities = 28/93 (30%), Positives = 41/93 (44%), Gaps = 6/93 (6%)
Query: 28 TVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAG--SASDRF 85
T R + + LA I + S VY EGE+ +C G P P + W + S S R
Sbjct: 32551 TTRKIKTTLAARILTKPRSMTVY---EGESARFSCDTDGEPVPTVTWLRKGQVLSTSARH 32607
Query: 86 Q-DSSVFNETLRITNIQRHQGGRYYCKAENGLG 117
Q ++ + T I+++Q G Y EN G
Sbjct: 32608 QVTTTKYKSTFEISSVQASDEGNYSVVVENSEG 32640
Score = 38.1 bits (87), Expect = 0.040
Identities = 86/415 (20%), Positives = 145/415 (34%), Gaps = 59/415 (14%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGS-ASDRFQDSSVFNETLRITNIQRHQGGRYYC 110
+ G + + V+G P P + W + + +++ + ++ I N QR G Y
Sbjct: 16536 VHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSL 16595
Query: 111 KAENGLGSPAIKSIRVDVYYLDDPVVT---VHQSIGEAKEQFYYER--------TVFLRC 159
A+N G K+I VDV + PV T H E+ + ++ T ++
Sbjct: 16596 LAKNEAGERK-KTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIE 16654
Query: 160 VANSN----PPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYS 215
S+ PV Y+ R Q +QG +G + +I ++ + S
Sbjct: 16655 KRESDRRAWTPVTYTVTR-QNATVQGLIQGKAYF--------FRIAAENSIGMGPFVETS 16705
Query: 216 CIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSL 275
+R +P++ + T + ++ L + P E I V +
Sbjct: 16706 EALVIREPITVPERPEDLEVKEVTKN-TVTLTWNPPKYDGGSEIINYVLES--------- 16755
Query: 276 TWVRSFGTLPEKTVLNGGTL----TIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRAL 331
R GT V N L T+ + D Y A N VG +
Sbjct: 16756 ---RLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCK 16812
Query: 332 KKGRFWITPDPYHKDD----NIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMV 387
+ + P H D I++G ++ + P ++ SWFK+ + +R
Sbjct: 16813 DE----LAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKV--SWFKDEADVLEDDRTH 16866
Query: 388 ITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPP 442
I T P T L+ I K +D G Y CV G VN+ PP
Sbjct: 16867 IKTT-----PATLALEKIKAKRSDSGKY-CVVVENSTGSRKGFCQVNVVDRPGPP 16915
Score = 38.1 bits (87), Expect = 0.040
Identities = 39/168 (23%), Positives = 74/168 (44%), Gaps = 11/168 (6%)
Query: 400 TNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVN----ISSSTVPPNLTVPQEKSPLVT 455
T + DLK ++ VA++ G+S+ S + + +P K +
Sbjct: 29400 TEFTVPDLKMGQKYSFR-VAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTI 29458
Query: 456 REGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRC 515
R G ++ L V+G+P P+I WS+ ++A ESY L + V+R +G Y
Sbjct: 29459 RAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESY-SLLIVDKVNRYDAGKYTI 29517
Query: 516 QTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRV 563
+ +G + A V + V P P+ +++++ SVT++ +
Sbjct: 29518 EAENQSG----KKSATVLVKVYDTPGPCPS-VKVKEVSRDSVTITWEI 29560
Score = 38.1 bits (87), Expect = 0.040
Identities = 64/299 (21%), Positives = 111/299 (37%), Gaps = 38/299 (12%)
Query: 257 GEAITLVCVTTGGEPAPSLTWVRSFGTLP-----EKTVLNG-GTLTIPAITSDDAGTYSC 310
G + VC + + +TW L E T +G L + IT D GTY C
Sbjct: 31582 GGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRC 31641
Query: 311 IANNNVGNPA------------------KKSTNIIVRALKKGRFWITPDPYHK---DDNI 349
N+ G + +++ I R R P + +
Sbjct: 31642 KVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTA 31701
Query: 350 QIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKF 409
+G V+ + P +T W+K+G+ ++ + + D G L I +
Sbjct: 31702 YVGENVRFGVTITVHPEPHVT--WYKSGQKIKPGDNDKKYTFESD--KGLYQLTINSVTT 31757
Query: 410 TDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTV-PQEKSPLVT---REGDTIELQC 465
D YT VA K G S + ++ P + T+ P K L +EG ++ +
Sbjct: 31758 DDDAEYTVVARNKYGEDS-CKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEI 31816
Query: 466 QVTGKPKPIILWSRADKEVAM-PDGSMQMESYD-GTLRIVNVSREMSGMYRCQTSQYNG 522
+V+G P P + W + + +++ P+ + E D L I + E +G YR + G
Sbjct: 31817 RVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAG 31875
Score = 37.7 bits (86), Expect = 0.052
Identities = 28/90 (31%), Positives = 41/90 (45%), Gaps = 7/90 (7%)
Query: 49 VYTIREGETLELTCLVTGHPRPQIRWTKTA----GSASDRFQDSSVFNETLRITNIQRHQ 104
V + GET L + G P P + W+K +A+ S++ TL + + R
Sbjct: 24716 VIVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTD 24775
Query: 105 GGRYYCKAENGLGSPAIKSIRVDVYYLDDP 134
GG+Y K N G+ KSI + V LD P
Sbjct: 24776 GGQYILKLSNVGGT---KSIPITVKVLDRP 24802
Score = 37.7 bits (86), Expect = 0.052
Identities = 34/115 (29%), Positives = 46/115 (40%), Gaps = 18/115 (15%)
Query: 24 YAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASD 83
YAPP + + R + TIR G L L V G P P+I WTK D
Sbjct: 29041 YAPPKAEL----------DARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTK-GDKELD 29089
Query: 84 RFQDSSVFNETLRITNI----QRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDP 134
+ S+ R T + R G+Y +N G+ K++ V V LD P
Sbjct: 29090 LCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGT---KAVSVMVKVLDSP 29141
Score = 37.4 bits (85), Expect = 0.067
Identities = 29/90 (32%), Positives = 40/90 (44%), Gaps = 12/90 (13%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNE------TLRITNIQRHQ 104
T++ G +EL VTG P P+I WTK QD + E T+ I + +R
Sbjct: 13701 TVKAGTKIELPATVTGKPEPKITWTKADMILK---QDKRITIENVPKKSTVTIVDSKRSD 13757
Query: 105 GGRYYCKAENGLGSPAIKSIRVDVYYLDDP 134
G Y +A N G + V+V LD P
Sbjct: 13758 TGTYIIEAVNVCGR---ATAVVEVNVLDKP 13784
Score = 37.4 bits (85), Expect = 0.067
Identities = 30/109 (27%), Positives = 43/109 (39%), Gaps = 18/109 (16%)
Query: 14 LLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIR 73
L E + + + PP V + + C V T+R G+T+ + V G P P I
Sbjct: 17893 LAESVIAKDILHPPEVEL---DVTCR--------DVITVRVGQTIRILARVKGRPEPDIT 17941
Query: 74 WTK-----TAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLG 117
WTK D QD + L+I R G+Y A+N G
Sbjct: 17942 WTKEGKVLVREKRVDLIQD--LPRVELQIKEAVRADHGKYIISAKNSSG 17988
Score = 37.4 bits (85), Expect = 0.067
Identities = 23/108 (21%), Positives = 48/108 (44%), Gaps = 7/108 (6%)
Query: 440 VPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDG-SMQMESYDG 498
+PP + +P++ + + G + ++ V GKP P W + + EV ++
Sbjct: 18898 LPPKILMPEQ---ITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSS 18954
Query: 499 TLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAF 546
L I +V+R+ SG Y +G + + + +++ P +P F
Sbjct: 18955 ILIIKDVTRKDSGYYSLTAENSSGTDT---QKIKVVVMDAPGPPQPPF 18999
Score = 37.4 bits (85), Expect = 0.067
Identities = 69/301 (22%), Positives = 116/301 (38%), Gaps = 51/301 (16%)
Query: 441 PPNLTV-PQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYD-- 497
PP +++ P+ K +V G++ ++ + GKP P I W + D+E++ ++++S D
Sbjct: 22540 PPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELS-NTARLEIKSTDFA 22598
Query: 498 GTLRIVNVSREMSGMYRCQTSQYNG-----FNVK------PREALVQL---------IVQ 537
+L + + R SG Y + G NVK P E V + +
Sbjct: 22599 TSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAW 22658
Query: 538 YPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYA 597
PP + I +R T S V V T ++ KLL E EY
Sbjct: 22659 KPPLQDGGSDIINYIVERRET-SRLVWTVVDANVQTLSCKV-TKLL--------EGNEYT 22708
Query: 598 VKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQW 657
+ ++ YGV + +E + F+V APE T + S + W
Sbjct: 22709 FRIMAVNKYGVGE-PLESEPVVAKNPFVVPDAPKAPEVTTVTKD----------SMIVVW 22757
Query: 658 TQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRL 717
+ D I+ Y L R RW ++ G ++ +T LI+ YE R+
Sbjct: 22758 ERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELR------LRVTGLIENHDYEFRV 22811
Query: 718 T 718
+
Sbjct: 22812 S 22812
Score = 37.4 bits (85), Expect = 0.067
Identities = 26/96 (27%), Positives = 46/96 (47%), Gaps = 7/96 (7%)
Query: 42 EERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQ---DSSVFNETLRIT 98
+ +Y + + + GE+ ++ + G P P I+W K S+ + S+ F +L +
Sbjct: 22546 DPKYKDTI-VVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFATSLSVK 22604
Query: 99 NIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDP 134
+ R G Y KA+N G +S+ V+V LD P
Sbjct: 22605 DAVRVDSGNYILKAKNVAGE---RSVTVNVKVLDRP 22637
Score = 37.4 bits (85), Expect = 0.067
Identities = 35/171 (20%), Positives = 68/171 (39%), Gaps = 29/171 (16%)
Query: 209 QDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVD--DPIVVNPGEAITLVCVT 266
Q Y+ +V+ + + + + P ++L D + + G ++ L+ V+
Sbjct: 29411 QKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLM-VS 29469
Query: 267 TGGEPAPSLTWVRSFGTLPEKTVLNG----GTLTIPAITSDDAGTYSCIANNNVGNPAKK 322
G P P +TW + L + +++ L + + DAG Y+ A N G KK
Sbjct: 29470 VSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSG---KK 29526
Query: 323 STNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSW 373
S ++V+ + TP P S +V+ V + +T +W
Sbjct: 29527 SATVLVKV------YDTPGPCP-------------SVKVKEVSRDSVTITW 29558
Score = 37.0 bits (84), Expect = 0.088
Identities = 78/315 (24%), Positives = 118/315 (37%), Gaps = 52/315 (16%)
Query: 67 HPRPQIRWTKTAGSA--SDRFQDS-SVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKS 123
+P ++ W K SD+F+ S TLR+ N Q G Y P I S
Sbjct: 8683 YPEIKLSWYKGTEKLEPSDKFEISIDGDRHTLRVKNCQLKDQGNYRLVC-----GPHIAS 8737
Query: 124 IRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLL-QGS 182
++ V +P H KE +T + C S P V+ W R +L QG
Sbjct: 8738 AKLTVI---EPAWERHLQDVTLKEG----QTCTMTCQF-SVPNVKSEWFRNGRILKPQGR 8789
Query: 183 DKGVEIYEPFFTQGETKILKLK--NLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTA 240
K T+ E K+ KL ++R +D Y+C D S L +
Sbjct: 8790 HK---------TEVEHKVHKLTIADVRAEDQGQYTC--------KYEDLETSAELRIEAE 8832
Query: 241 SPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGT------ 294
+ + IVV+ ++ T C + + +TW + L E N
Sbjct: 8833 PIQFTKRIQN-IVVSEHQSATFECEVSFDDAI--VTWYKGPTELTESQKYNFRNDGRCHY 8889
Query: 295 LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGRE 354
+TI +T DD G YS IA A +ST + K+ + + P P D + I
Sbjct: 8890 MTIHNVTPDDEGVYSVIARLEPRGEA-RSTAELYLTTKEIKLELKP-PDIPDSRVPIP-- 8945
Query: 355 VKISCQVEAVPSEEL 369
+ + AVP EE+
Sbjct: 8946 ---TMPIRAVPPEEI 8957
Score = 37.0 bits (84), Expect = 0.088
Identities = 71/326 (21%), Positives = 116/326 (35%), Gaps = 61/326 (18%)
Query: 450 KSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVN--VSR 507
K ++ + G+ L+ V+G+P P + WS+ KE+ ++++ D + +VN +R
Sbjct: 21468 KDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELE-GTAKLEIKIADFSTNLVNKDSTR 21526
Query: 508 EMSGMYRCQTSQYNG-----FNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCR 562
SG Y + G FNVK + PP A E VT
Sbjct: 21527 RDSGAYTLTATNPGGFAKHIFNVKVLDR------PGPPEGPLAVTE--------VTSEKC 21572
Query: 563 VLRAYP--------IRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSII 614
VL +P I + R ++L T + T+ V L N ++ +
Sbjct: 21573 VLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAV 21632
Query: 615 NEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVY------SYSLQWTQMNPDAVDRI 668
N+ G G P + Y P ++ S + W + D I
Sbjct: 21633 NKYGVGE------PLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEI 21686
Query: 669 VAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRL----------- 717
+ Y + R QRW IK N + Y ++ L + YE R+
Sbjct: 21687 INYIVERRDKAGQRW----IKCNKKTLTD--LRYKVSGLTEGHEYEFRIMAENAAGISAP 21740
Query: 718 TPLTKFGEGDSTIRVIKYSAPVNPHL 743
+P + F + T V K P NP +
Sbjct: 21741 SPTSPFYKACDT--VFKPGPPGNPRV 21764
Score = 37.0 bits (84), Expect = 0.088
Identities = 44/178 (24%), Positives = 70/178 (39%), Gaps = 20/178 (11%)
Query: 297 IPAITSDDAGTYSCIANNNVG--NPAKKSTNIIVRALKKGRFWITPDPYHKDDNI-QIGR 353
+ + D + IA N G + +ST I + I+ DP +KD + G
Sbjct: 22500 VTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGE 22559
Query: 354 EVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFG 413
K+ + P T W K + L ++ R+ I TD T+L + D D G
Sbjct: 22560 SFKVDADIYGKPIP--TIQWIKGDQELSNTARLEIKSTD-----FATSLSVKDAVRVDSG 22612
Query: 414 TYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKP 471
Y A G S ++++V + PP + P+V G T E +C + KP
Sbjct: 22613 NYILKAKNVAGERS-VTVNVKVLDRPGPP-------EGPVVI-SGVTAE-KCTLAWKP 22660
Score = 37.0 bits (84), Expect = 0.088
Identities = 68/347 (19%), Positives = 130/347 (37%), Gaps = 26/347 (7%)
Query: 389 TQTDPDVSPGTTNLDIIDL-KFTDFGTYTCVASLKG-GGISDISIDVNISSSTVPPNLTV 446
T P TN+++ L + ++ C + G G +D+ + + P++ +
Sbjct: 22885 TMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDL 22944
Query: 447 PQEKSPLVT-REGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNV 505
E ++ R G ++ L + G+P P + W + D E+ + + S +L + NV
Sbjct: 22945 DLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEI-RDAAIIDVTSSFTSLVLDNV 23003
Query: 506 SREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVL- 564
+R SG Y +G K V+++ P V EI + S+T +L
Sbjct: 23004 NRYDSGKYTLTLENSSG--TKSAFVTVRVLDTPSPPVNLKVTEITK-DSVSITWEPPLLD 23060
Query: 565 RAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAG---- 620
I+ E R + + + + L + + NE G G
Sbjct: 23061 GGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQ 23120
Query: 621 RCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQ 680
+ + P T + V +N S SL WT+ D +I+ Y + ++
Sbjct: 23121 TADPIKVAEVPQPPGKI-TVDDVTRN-----SVSLSWTKPEHDGGSKIIQYIVEMQAKHS 23174
Query: 681 QRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGD 727
++W E ++ + + NLT+ E Y R+ + + G D
Sbjct: 23175 EKWSE-----CARVKSLQAVITNLTQ---GEEYLFRVVAVNEKGRSD 23213
Score = 37.0 bits (84), Expect = 0.088
Identities = 56/273 (20%), Positives = 104/273 (38%), Gaps = 38/273 (13%)
Query: 2 DLLYGLVWLLTVLLEGISGQGVYAPPTVRIV-HSGLACNIEEERYSERVYTIREGETLEL 60
+L+ GL + V E + G+ ++ + I S + + R +R L
Sbjct: 30888 NLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATL 30947
Query: 61 TCLVTGHPRPQIRWTK-----TAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENG 115
C VTGHP+P ++W + A R Q+ L I ++ Y +A N
Sbjct: 30948 VCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQ 31007
Query: 116 LGS-PAIKSIRVDV---YYLD---DPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
GS S+ V+V +L + + VH GE V ++ + P
Sbjct: 31008 GGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGE---------VVSIKIPFSGKPDPV 31058
Query: 169 YSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVR------- 221
+W++GQ+++ Y+ T+ T ++ + +D Y A R
Sbjct: 31059 ITWQKGQDLIDNNGH-----YQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKT 31113
Query: 222 ---NVCNIPDKMVSFRLSNKTASPSIKLLVDDP 251
+V ++PD ++S+ + S+ L +P
Sbjct: 31114 VELDVADVPDPPRGVKVSD-VSRDSVNLTWTEP 31145
Score = 36.6 bits (83), Expect = 0.12
Identities = 26/87 (29%), Positives = 38/87 (43%), Gaps = 8/87 (9%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSV----FNETLRITNIQRHQGGR 107
++ G T+ ++ G P P +WT T GS + +V F+ L I N R G
Sbjct: 17522 VKAGTTVRFPAIIRGVPVPTAKWT-TDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGE 17580
Query: 108 YYCKAENGLGSPAIKSIRVDVYYLDDP 134
Y N GS K++ V + LD P
Sbjct: 17581 YQITVSNAAGS---KTVAVHLTVLDVP 17604
Score = 36.6 bits (83), Expect = 0.12
Identities = 46/176 (26%), Positives = 65/176 (36%), Gaps = 21/176 (11%)
Query: 265 VTTGGEPAPSLTWVRSF-----GTLPEKTVLNGGT----LTIPAITSDDAGTYSCIANNN 315
VT P P +TW +S G +K LTI ++T+DD Y+ +A N
Sbjct: 31711 VTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNK 31770
Query: 316 VGNPAKKSTNIIVRALKKGRFWITPDPYHK----DDNIQIGREVKISCQVEAVPSEELTF 371
G + K+ + L T P K + Q G+ V +V +P T
Sbjct: 31771 YGEDSCKAK--LTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPP--TL 31826
Query: 372 SWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS 427
W K+G+PL + I D L I D D G Y A+ G S
Sbjct: 31827 KWEKDGQPLSLGPNIEIIHEGLDYYA----LHIRDTLPEDTGYYRVTATNTAGSTS 31878
Score = 36.2 bits (82), Expect = 0.15
Identities = 37/142 (26%), Positives = 60/142 (42%), Gaps = 25/142 (17%)
Query: 591 QEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRV 650
QE TEY + + IN+AG G+ S + AYA + Y P + +V
Sbjct: 19553 QEGTEYE-----------FRVTAINKAGPGKPSD-ASKAAYARDPQYPPGPPAFP---KV 19597
Query: 651 Y-----SYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLT 705
Y S SL W + D I+ Y + +++A W + N+QK + +T
Sbjct: 19598 YDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNW--VRCNLPQNLQK---TRFEVT 19652
Query: 706 ELIKPEAYEVRLTPLTKFGEGD 727
L++ Y+ R+ + K G D
Sbjct: 19653 GLMEDTQYQFRVYAVNKIGYSD 19674
Score = 36.2 bits (82), Expect = 0.15
Identities = 53/268 (19%), Positives = 98/268 (36%), Gaps = 30/268 (11%)
Query: 138 VHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQG---SDKGVEIYEPFFT 194
V S+ AKE +Y+ L+ N + YS E+ + SD+G + E
Sbjct: 32739 VESSVLRAKEVTWYKDGKKLK--ENGHFQFHYSADGTYELKINNLTESDQGEYVCE-ISG 32795
Query: 195 QGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVV 254
+G T L+ + + + ++ + K ++ KT + + + P++V
Sbjct: 32796 EGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIV 32855
Query: 255 N-------PGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGT-----------LT 296
+++ V GEP P+ W + K + GG L
Sbjct: 32856 TGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKD-----GKAITQGGKYKLSEDKGGFFLE 32910
Query: 297 IPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVK 356
I + D+G Y+C N+ G+ S + ++A+K + Q V+
Sbjct: 32911 IHKTDTSDSGLYTCTVKNSAGS-VSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQ 32969
Query: 357 ISCQVEAVPSEELTFSWFKNGRPLRSSE 384
+A+ SEE+ S K+ L E
Sbjct: 32970 EEISQKALRSEEIKMSEAKSQEKLALKE 32997
Score = 35.8 bits (81), Expect = 0.20
Identities = 34/139 (24%), Positives = 56/139 (40%), Gaps = 14/139 (10%)
Query: 351 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT 410
+G C V PS +T +W K+G +R S + D L IID++ +
Sbjct: 11132 VGSSAIFECLVS--PSTAIT-TWMKDGSNIRESPKHRFIADGKD-----RKLHIIDVQLS 11183
Query: 411 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGK 470
D G YTCV L G + + + +P E+ V + G + L C++ +
Sbjct: 11184 DAGEYTCVLRL---GNKEKTSTAKLVVEELPVRFVKTLEEEVTVVK-GQPLYLSCELNKE 11239
Query: 471 PKPIILWSRADKEVAMPDG 489
++W + K V G
Sbjct: 11240 RD--VVWRKDGKIVVEKPG 11256
Score = 35.8 bits (81), Expect = 0.20
Identities = 35/120 (29%), Positives = 48/120 (40%), Gaps = 24/120 (20%)
Query: 26 PPTVRIVHSGLACNIEEERYSERVYTIR--EGETLELTCLVTGHPRPQIRWTK---TAGS 80
PPT+++ R S R TI+ GE + + VTG P P+I W+K
Sbjct: 15394 PPTIKL------------RLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEK 15441
Query: 81 ASDRFQ------DSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDP 134
+D Q S L I R G Y A N LGS +++ V+VY P
Sbjct: 15442 PTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGS-VFRNVHVEVYDRPSP 15500
Score = 35.8 bits (81), Expect = 0.20
Identities = 29/117 (24%), Positives = 49/117 (41%), Gaps = 16/117 (13%)
Query: 242 PSIKLLVD-DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGT----LT 296
P I+L D +VV A + VT G P P + W ++ G L ++ + + L
Sbjct: 25105 PEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLV 25164
Query: 297 IPAITSDDAGTYSCIANNNVGNPA-----------KKSTNIIVRALKKGRFWITPDP 342
I +T D+G Y+ NN G+ N+ +R +KK ++ +P
Sbjct: 25165 IDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEP 25221
Score = 35.8 bits (81), Expect = 0.20
Identities = 22/89 (24%), Positives = 39/89 (43%), Gaps = 6/89 (6%)
Query: 49 VYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNET---LRITNIQRHQG 105
V ++ GE L++ + G P P I W K +R + + + L + + R
Sbjct: 25798 VIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDT 25857
Query: 106 GRYYCKAENGLGSPAIKSIRVDVYYLDDP 134
G+Y +N G+ +S+ V+ LD P
Sbjct: 25858 GQYVLTLKNVAGT---RSVAVNCKVLDKP 25883
Score = 35.4 bits (80), Expect = 0.26
Identities = 102/482 (21%), Positives = 171/482 (35%), Gaps = 90/482 (18%)
Query: 252 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK-----TVLNG-GTLTIPAITSDDA 305
+ V GE++TL C +G P+P++TW R + T +G L I ++D+
Sbjct: 952 VTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDS 1010
Query: 306 GTYSCIANNNVGNPA-------------KKSTNIIVR--ALKKGRFWITPDPYHKDDNIQ 350
G ++C A N G + +K T + ++ RF + D D ++
Sbjct: 1011 GRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLT 1070
Query: 351 ------------------------IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERM 386
G V CQV P + W K+G PL + R
Sbjct: 1071 EEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHV--YWKKSGVPLTTGYRY 1128
Query: 387 VITQTDPDVSPGTTNLDIIDLKFT-DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLT 445
++ + G L +I + F D G YT V K G + S ++ L
Sbjct: 1129 KVSY---NKQTGECKL-VISMTFADDAGEYTIVVRNKHG---ETSASASLLEEADYELLM 1181
Query: 446 VPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV---------AMPDGSMQMESY 496
Q++ T+ T +Q G+ P ++S +KE M ++ + +Y
Sbjct: 1182 KSQQEMLYQTQV--TAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTY 1239
Query: 497 --DGTLRIVNVSREM--SGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAF----LE 548
D I + + YR + + E + + + AVE F
Sbjct: 1240 VEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKN 1299
Query: 549 IRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLS-----N 603
R + VT C+ + YP+ + W K ++ G+ ++ + SL
Sbjct: 1300 YRILEGMGVTFHCK-MSGYPLPKIA--WYKDGKRIKHGERYQMDFLQDGRASLRIPVVLP 1356
Query: 604 ENYGVYNCSIINEAGAGRCSFLVTGKAY---APEFYYDTYNPVWQNRHRVYSYSLQWTQM 660
E+ G+Y N G CS GK Y A TY P + R+ S S +
Sbjct: 1357 EDEGIYTAFASNIKGNAICS----GKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVSR 1412
Query: 661 NP 662
+P
Sbjct: 1413 SP 1414
Score = 35.4 bits (80), Expect = 0.26
Identities = 19/71 (26%), Positives = 29/71 (40%), Gaps = 3/71 (4%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNE---TLRITNIQRHQGGR 107
T+ EGE++ L C ++G+P P + W + F L I GR
Sbjct: 953 TVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGR 1012
Query: 108 YYCKAENGLGS 118
+ C A N G+
Sbjct: 1013 FTCSAVNEAGT 1023
Score = 35.4 bits (80), Expect = 0.26
Identities = 44/221 (19%), Positives = 90/221 (40%), Gaps = 33/221 (14%)
Query: 295 LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGRE 354
L I +++D+ Y+ + N+ + T I++ ++ K I E
Sbjct: 2938 LIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIMITSMLK----------------DINAE 2981
Query: 355 VKISCQVEA-VPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFG 413
K + E V E +++ W KNG ++S+++ + T +L+I ++ F D
Sbjct: 2982 EKDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQMR-----TKKLTHSLNIRNVHFGDAA 3036
Query: 414 TYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKP 473
YT VA K + + ++ ++ + + E +C+V+ +P
Sbjct: 3037 DYTFVAG-KATSTATLYVEAR--------HIEFRKHIKDIKVLEKKRAMFECEVS-EPDI 3086
Query: 474 IILWSRADKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMY 513
+ W + D+E+ + D +Q E Y L I + +G Y
Sbjct: 3087 TVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDAGKY 3127
Score = 35.0 bits (79), Expect = 0.33
Identities = 99/510 (19%), Positives = 192/510 (37%), Gaps = 101/510 (19%)
Query: 16 EGISGQGVYAPPTVRIVHSGLACNIEEERYSERVY--TIREGETLELTCLVTGHPRPQIR 73
+ ++ +G PT + L+ ++E + ER+ T+ +G V G P P+
Sbjct: 2051 KALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECE 2110
Query: 74 WTKTAGSA--SDR----FQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVD 127
W K SDR + + +V +R ++ KA N G + +
Sbjct: 2111 WYKNGVKIERSDRIYWYWPEDNVCELVIR--DVTAEDSASIMVKAINIAGETSSHAF--- 2165
Query: 128 VYYLDDPVVTVHQSIGE--AKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKG 185
+ ++T Q + + AKE+ + C S P V+ W + G
Sbjct: 2166 LLVQAKQLITFTQELQDVVAKEK---DTMATFEC-ETSEPFVKVKWYKD----------G 2211
Query: 186 VEIYEP----FFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTAS 241
+E++E + + L + + D +YSC+ + ++
Sbjct: 2212 MEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVL----------------VEDENVK 2255
Query: 242 PSIKLLVDDPIV----------VNPGEAITLVCVTTG----GEPAPSLTWVRSFGTLPEK 287
+ KL+V+ +V V + L C+ + G+ + ++S G
Sbjct: 2256 TTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKYTIT 2315
Query: 288 TVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDD 347
+ LT+ +T +D G YS + + K + L+ ++ + D
Sbjct: 2316 SRRGRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQ----GLSDQKVCEGD 2371
Query: 348 NIQIGREVKISCQ-VEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 406
+Q+ EVK+S + VE V W K+G+ ++ S+R+ I + + L I D
Sbjct: 2372 IVQL--EVKVSLESVEGV--------WMKDGQEVQPSDRVHIV-----IDKQSHMLLIED 2416
Query: 407 LKFTDFGTYTCVASLKG----GGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIE 462
+ D G Y+ G G +S S+DV +T ++ + + EG
Sbjct: 2417 MTKEDAGNYSFTIPALGLSTSGRVSVYSVDV----------ITPLKDVNVI---EGTKAV 2463
Query: 463 LQCQVTGKPKPIILWSRADKEVAMPDGSMQ 492
L+C+V+ + W D+++ PD +Q
Sbjct: 2464 LECKVSVPDVTSVKWYLNDEQI-KPDDRVQ 2492
Score = 35.0 bits (79), Expect = 0.33
Identities = 25/103 (24%), Positives = 42/103 (40%), Gaps = 9/103 (8%)
Query: 429 ISIDVNISSSTVPPN--LTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAM 486
+ ++V I VPP L + + + G+ + + VTG P P I WS+ + +
Sbjct: 15382 LPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEK 15441
Query: 487 PDGSMQMESYDGT-------LRIVNVSREMSGMYRCQTSQYNG 522
P ++Q+ + + L I RE G Y S G
Sbjct: 15442 PTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLG 15484
Score = 35.0 bits (79), Expect = 0.33
Identities = 25/90 (27%), Positives = 39/90 (43%), Gaps = 4/90 (4%)
Query: 50 YTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQ---DSSVFNETLRITNIQRHQGG 106
Y+I+ GE L++ V G PRP I W K + + + + L I + G
Sbjct: 24321 YSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFG 24380
Query: 107 RYYCKAENGLGSPAIKSIRVDVYYLDDPVV 136
+Y A N G+ A +++ V V P V
Sbjct: 24381 KYTVTATNSAGT-ATENLSVIVLEKPGPPV 24409
Score = 35.0 bits (79), Expect = 0.33
Identities = 26/80 (32%), Positives = 38/80 (47%), Gaps = 4/80 (5%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDR--FQDSSVFNET-LRITNIQRHQGGRY 108
I+ GE+L + LV G P P++ W K R + + V T L + + R G Y
Sbjct: 27970 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVY 28029
Query: 109 YCKAENGLGSPAIKSIRVDV 128
+A+N GS A I+V V
Sbjct: 28030 TVEAKNASGS-AKAEIKVKV 28048
Score = 35.0 bits (79), Expect = 0.33
Identities = 35/154 (22%), Positives = 62/154 (40%), Gaps = 19/154 (12%)
Query: 590 SQEYTEYAVKSLSNENYGVYNCSIINEAG--AGRCSFLVTGKAYAPEFYYDTYNPVWQNR 647
S+ +TE +K + G Y+ + N+ G A V G +PE P+ +
Sbjct: 30186 SETHTELVIKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGSPNSPE------GPLEYDD 30239
Query: 648 HRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTEL 707
+V S + W D I+ Y L R+ + W+ + ++ G L+ L E
Sbjct: 30240 IQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGT----SLVVKGLKEN 30295
Query: 708 IKPEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNP 741
++ Y R++ +FG + +K PV P
Sbjct: 30296 VE---YHFRVSAENQFG----ISKPLKSEEPVTP 30322
Score = 35.0 bits (79), Expect = 0.33
Identities = 63/317 (19%), Positives = 120/317 (37%), Gaps = 59/317 (18%)
Query: 321 KKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPL 380
+KST ++ R P + + G + SC + P +T W + G+ L
Sbjct: 32548 EKSTTRKIKTTLAARILTKP----RSMTVYEGESARFSCDTDGEPVPTVT--WLRKGQVL 32601
Query: 381 RSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVA-SLKGGGISDISIDVNISSST 439
+S R +T T + +I ++ +D G Y+ V + +G ++ ++ + + T
Sbjct: 32602 STSARHQVTTTKYK-----STFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVT 32656
Query: 440 VPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT 499
+ P+ KSP + P+ + ++ K V P+ S
Sbjct: 32657 EKAVTSPPRVKSPEPRVKS------------PEAV----KSPKRVKSPEPS--------- 32691
Query: 500 LRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTM 559
+ +T P E + L V PP + FL+ ++ + +
Sbjct: 32692 --------HPKAVSPTETKP------TPTEKVQHLPVSAPPKITQ-FLKAEASKEIA-KL 32735
Query: 560 SCRVLRAYPIRVLTYEW-RLGNKLLRTGQFD---SQEYT-EYAVKSLSNENYGVYNCSII 614
+C V+ + +R W + G KL G F S + T E + +L+ + G Y C I
Sbjct: 32736 TC-VVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEIS 32794
Query: 615 NEAGAGRCSFLVTGKAY 631
E G + + G+A+
Sbjct: 32795 GEGGTSKTNLQFMGQAF 32811
Score = 34.7 bits (78), Expect = 0.44
Identities = 24/125 (19%), Positives = 55/125 (44%), Gaps = 8/125 (6%)
Query: 424 GGISDISIDVNISSSTVPPNLTVPQE-KSPLVTREGDTIELQCQVTGKPKPIILWSRADK 482
G ++D+ + + V P+L + + +V G I + V+GKP P + W+ ++
Sbjct: 16507 GEVTDV---IEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNER 16563
Query: 483 EVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV 542
+ + +++ + ++ I N R G+Y G + ++ ++ ++ P V
Sbjct: 16564 TLPQ-EATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAG---ERKKTIIVDVLDVPGPV 16619
Query: 543 EPAFL 547
FL
Sbjct: 16620 GTPFL 16624
Score = 34.3 bits (77), Expect = 0.57
Identities = 16/44 (36%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Query: 442 PNLTVPQEKSPLVT-REGDTIELQCQVTGKPKPIILWSRADKEV 484
P + +P E + +V R G +++L+ ++GKP P I W + DKE+
Sbjct: 26870 PVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKEL 26913
Score = 33.9 bits (76), Expect = 0.75
Identities = 32/120 (26%), Positives = 51/120 (42%), Gaps = 36/120 (30%)
Query: 269 GEPAPSLTWVRS------------FGTLPEKTVLNGG-TLTIPAITSDDAGTYSCIANNN 315
G P P+LTW ++ + T K V++ TL IP D G Y+ A NN
Sbjct: 16142 GVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNN 16201
Query: 316 VGNPAKK-STNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWF 374
+G +K+ N++ R P P +G + E+V ++++T SWF
Sbjct: 16202 LGTASKEMRLNVLGR----------PGP-------PVG-----PIKFESVSADQMTLSWF 16239
Score = 33.9 bits (76), Expect = 0.75
Identities = 27/90 (30%), Positives = 38/90 (42%), Gaps = 12/90 (13%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTK------TAGSASDRFQDSSVFNETLRITNIQRHQ 104
TI+ G+ L + V G P P +W K T+ + DSS L I ++ R
Sbjct: 18909 TIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSS---SILIIKDVTRKD 18965
Query: 105 GGRYYCKAENGLGSPAIKSIRVDVYYLDDP 134
G Y AEN G+ K + V +D P
Sbjct: 18966 SGYYSLTAENSSGTDTQK---IKVVVMDAP 18992
Score = 33.9 bits (76), Expect = 0.75
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 6/87 (6%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTK--TAGSASDRFQDSSVFNE-TLRITNIQRHQGGR 107
T++ G + L V G P P + W K T ++ + + N TL + ++ R G
Sbjct: 19306 TVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGD 19365
Query: 108 YYCKAENGLGSPAIKSIRVDVYYLDDP 134
Y AEN GS KS + + LD P
Sbjct: 19366 YTITAENSSGS---KSATIKLKVLDKP 19389
Score = 33.9 bits (76), Expect = 0.75
Identities = 23/85 (27%), Positives = 36/85 (42%), Gaps = 8/85 (9%)
Query: 241 SPSIKL--LVDDPIVVNPGEAITLVCVTTGGEPAPSLTW------VRSFGTLPEKTVLNG 292
+P+I L + D + + G+ I L ++ G+P P +W +R +
Sbjct: 20375 APTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS 20434
Query: 293 GTLTIPAITSDDAGTYSCIANNNVG 317
LTI T DAG Y+ A N G
Sbjct: 20435 SMLTIKYATRKDAGEYTITATNPFG 20459
Score = 33.9 bits (76), Expect = 0.75
Identities = 22/84 (26%), Positives = 38/84 (45%), Gaps = 4/84 (4%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDR-FQDSSVFNETLRITNIQRHQGGRYYC 110
++ G + +T G P P + W+K R + D++ +L I N R+ G+Y
Sbjct: 26198 VKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTL 26257
Query: 111 KAENGLGSPAIKSIRVDVYYLDDP 134
+N L + S+ + V LD P
Sbjct: 26258 TIQNVLSA---ASLTLVVKVLDTP 26278
Score = 33.9 bits (76), Expect = 0.75
Identities = 41/210 (19%), Positives = 84/210 (40%), Gaps = 16/210 (7%)
Query: 342 PYHKDD----NIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSP 397
P+ K++ N++ + C+V P + W++ G+ + + Q +
Sbjct: 30928 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIV--KWYRQGKEIIADGLKYRIQ---EFKG 30982
Query: 398 GTTNLDIIDLKFTDFGTYTCVASLKGGGISDI-SIDVNISSSTVPPNLTVPQEKSPLVTR 456
G L I + D Y A+ +GG +S S++V + + P + +
Sbjct: 30983 GYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTL--EGMGAVHAL 31040
Query: 457 EGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQM---ESYDGTLRIVNVSREMSGMY 513
G+ + ++ +GKP P+I W + +++ +G Q+ S+ + V R+ +G Y
Sbjct: 31041 RGEVVSIKIPFSGKPDPVITWQKG-QDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFY 31099
Query: 514 RCQTSQYNGFNVKPREALVQLIVQYPPAVE 543
G + K E V + P V+
Sbjct: 31100 VVCAKNRFGIDQKTVELDVADVPDPPRGVK 31129
Score = 33.5 bits (75), Expect = 0.97
Identities = 70/348 (20%), Positives = 131/348 (37%), Gaps = 27/348 (7%)
Query: 242 PSIKLLVDDPIVVN--PGEAITLVCVTTGGEPAPSLTWVRSFGTLPE----KTVLNGGT- 294
P+ + P+V G ++ C GG P P + W +S L K N T
Sbjct: 1079 PAAPYFITKPVVQKLVEGGSVVFGC-QVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTG 1137
Query: 295 ---LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI 351
L I +DDAG Y+ + N G + S +++ A + + ++
Sbjct: 1138 ECKLVISMTFADDAGEYTIVVRNKHGETSA-SASLLEEADYELLMKSQQEMLYQTQVTAF 1196
Query: 352 GREVKISCQVEAVPSEELTFSWFKNGRPLR---SSERMVITQTDPDVSPGTTNLD---II 405
+E K+ E + K +R + + +V+ D ++ + I
Sbjct: 1197 VQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIK 1256
Query: 406 DLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQC 465
++++ T T L+ G +++D++ S V + ++ EG + C
Sbjct: 1257 EIEYRIIKT-TLEELLEEDGEEKMAVDIS-ESEAVESGFDSRIKNYRIL--EGMGVTFHC 1312
Query: 466 QVTGKPKPIILWSRADKEVAMPDGSMQMESYDG--TLRIVNVSREMSGMYRCQTSQYNGF 523
+++G P P I W + K + + DG +LRI V E G+Y S G
Sbjct: 1313 KMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGN 1372
Query: 524 NVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRV 571
+ + V+ P P ++ + R ++S R + PIR+
Sbjct: 1373 AICSGKLYVE---PAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRM 1417
Score = 33.1 bits (74), Expect = 1.3
Identities = 11/23 (47%), Positives = 16/23 (69%)
Query: 52 IREGETLELTCLVTGHPRPQIRW 74
+ EGET C VTG+P+P++ W
Sbjct: 1852 VLEGETARFRCRVTGYPQPKVNW 1874
Score = 33.1 bits (74), Expect = 1.3
Identities = 10/30 (33%), Positives = 20/30 (66%)
Query: 453 LVTREGDTIELQCQVTGKPKPIILWSRADK 482
++ + GD I+++ V G+PKP + W + D+
Sbjct: 21075 VIAKAGDNIKVEIPVLGRPKPTVTWKKGDQ 21104
Score = 32.7 bits (73), Expect = 1.7
Identities = 60/234 (25%), Positives = 90/234 (38%), Gaps = 36/234 (15%)
Query: 104 QGGRYYCK--AEN--GLGSPAIKSIRVDVYYLDDPV-VTVHQSIGEAKEQFYYERTVFLR 158
QG Y K A N G G PA Y+D+PV ++ ++ + E +
Sbjct: 13553 QGKEYLFKVCARNKCGPGEPA---------YVDEPVNMSTPATVPDPPENVKWRDRTANS 13603
Query: 159 CVANSNPPVRYSWRRGQEVLLQ----GSDKGVEIYEPFFTQGETKILKLKNLRPQDYANY 214
+PP R + +++ GSDK V EP ETK +++ L + Y
Sbjct: 13604 IFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPV---AETK-MEVTGLEEGKWYAY 13659
Query: 215 SCIASVRNVCNIPDKMVS-FRLSNKTASPSI----KLLVDDPIVVNPGEAITLVCVTTGG 269
A R + P + + + +P I KLL + V G I L TG
Sbjct: 13660 RVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAG--LTVKAGTKIELPATVTG- 13716
Query: 270 EPAPSLTWVRSFGTLPE------KTVLNGGTLTIPAITSDDAGTYSCIANNNVG 317
+P P +TW ++ L + + V T+TI D GTY A N G
Sbjct: 13717 KPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCG 13770
Score = 32.7 bits (73), Expect = 1.7
Identities = 27/107 (25%), Positives = 46/107 (42%), Gaps = 16/107 (14%)
Query: 227 PDKMVSFRLSNKTASPSIKLLVD---DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGT 283
P ++ + + P+IKL + D I V GE + + TG P P + W ++
Sbjct: 15380 PSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTG-LPMPKIEWSKNETV 15438
Query: 284 LPEKTVLNGGT------------LTIPAITSDDAGTYSCIANNNVGN 318
+ + T T L+IP +D GTY+ A+N +G+
Sbjct: 15439 IEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGS 15485
Score = 32.7 bits (73), Expect = 1.7
Identities = 32/126 (25%), Positives = 48/126 (38%), Gaps = 22/126 (17%)
Query: 14 LLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIR 73
L E I + + PP I+ + ++ +R G + L +V G P P++
Sbjct: 18591 LKEAIKPKEILEPP-----------EIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVT 18639
Query: 74 WTKTAGSASDR-----FQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDV 128
W K R D+ F L I N R G+Y N G K++ V+V
Sbjct: 18640 WRKVGIDNVVRKGQVDLVDTMAF---LVIPNSTRDDSGKYSLTLVNPAGE---KAVFVNV 18693
Query: 129 YYLDDP 134
LD P
Sbjct: 18694 RVLDTP 18699
Score = 32.7 bits (73), Expect = 1.7
Identities = 25/83 (30%), Positives = 36/83 (43%), Gaps = 8/83 (9%)
Query: 253 VVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK----TVLNGGTLTIPAITSDDAGTY 308
VV G +I L + G P P+ W + L + T + TLT+ +DAG Y
Sbjct: 28368 VVRAGASIRLF-IAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKY 28426
Query: 309 SCIANNNVGNPAKKSTNIIVRAL 331
+ NN G+ KS V+ L
Sbjct: 28427 TLTVENNSGS---KSITFTVKVL 28446
Score = 32.3 bits (72), Expect = 2.2
Identities = 21/83 (25%), Positives = 37/83 (44%), Gaps = 4/83 (4%)
Query: 433 VNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQ 492
+ PP L + + L R G+ L + +GKPKP + W + + +V + D
Sbjct: 16809 ITCKDELAPPTLHL-DFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADV-LEDDRTH 16866
Query: 493 MESYDGTLRI--VNVSREMSGMY 513
+++ TL + + R SG Y
Sbjct: 16867 IKTTPATLALEKIKAKRSDSGKY 16889
Score = 32.3 bits (72), Expect = 2.2
Identities = 26/88 (29%), Positives = 38/88 (43%), Gaps = 6/88 (6%)
Query: 50 YTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQ---DSSVFNETLRITNIQRHQGG 106
+T+ GE L++ G P P + W K + +S+ N L I + R G
Sbjct: 22157 FTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVG 22216
Query: 107 RYYCKAENGLGSPAIKSIRVDVYYLDDP 134
Y K N G AI+++ V V LD P
Sbjct: 22217 HYVVKLTNSAGE-AIETLNVIV--LDKP 22241
Score = 32.3 bits (72), Expect = 2.2
Identities = 21/69 (30%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTKTA--GSASDRFQDSSVFNE-TLRITNIQRHQGGR 107
T+R G + L G P+P I W K S+ + S N+ TL I N ++ GG+
Sbjct: 27574 TVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGK 27633
Query: 108 YYCKAENGL 116
Y +N +
Sbjct: 27634 YTVILDNAV 27642
Score = 32.0 bits (71), Expect = 2.8
Identities = 21/74 (28%), Positives = 28/74 (37%), Gaps = 11/74 (14%)
Query: 52 IREGETLELTCLVTGHPRPQIRW--------TKTAGSASDRFQDSSVFNETLRITNIQRH 103
+ EG T ++G P P++ W T T F D L I + +
Sbjct: 17 VLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDG---RAKLTIPAVTKA 73
Query: 104 QGGRYYCKAENGLG 117
GRY KA NG G
Sbjct: 74 NSGRYSLKATNGSG 87
Score = 32.0 bits (71), Expect = 2.8
Identities = 21/74 (28%), Positives = 32/74 (43%), Gaps = 1/74 (1%)
Query: 441 PPNLTVPQEKSPLV-TREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT 499
PP + + LV R G I L V G+P P + W + + + G + +
Sbjct: 18603 PPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAF 18662
Query: 500 LRIVNVSREMSGMY 513
L I N +R+ SG Y
Sbjct: 18663 LVIPNSTRDDSGKY 18676
Score = 32.0 bits (71), Expect = 2.8
Identities = 54/263 (20%), Positives = 101/263 (38%), Gaps = 14/263 (5%)
Query: 450 KSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT--LRIVNVSR 507
++ ++ + G+ +++ G+P P + W + +K + D +E+ D + L I V+R
Sbjct: 27278 RTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLG-SDARYSIENTDSSSLLTIPQVTR 27336
Query: 508 EMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTM---SCRVL 564
+G Y G +P+ + V + V PA L+++ +VT+ +
Sbjct: 27337 NDTGKYILTIENGVG---EPKSSTVSVKVLDTPAACQK-LQVKHVSRGTVTLLWDPPLID 27392
Query: 565 RAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGR-CS 623
PI E R K + T + + LS + + NE G G C
Sbjct: 27393 GGSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCE 27452
Query: 624 FLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRW 683
T A E + ++ + S L WT+ + D I Y + + G+Q W
Sbjct: 27453 --TTEPVKAAEVPAPIRDLSMKDSTKT-SVILSWTKPDFDGGSVITEYVVERKGKGEQTW 27509
Query: 684 WEQEIKINGNIQKGELITYNLTE 706
I I+ +L ++ E
Sbjct: 27510 SHAGISKTCEIEVSQLKEQSVLE 27532
Score = 31.6 bits (70), Expect = 3.7
Identities = 31/156 (19%), Positives = 55/156 (35%), Gaps = 42/156 (26%)
Query: 359 CQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCV 418
C++ + + W +G+PL ++ R+ + G +LD D G TC
Sbjct: 1724 CRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEF-----GYCSLDYGVAYSRDSGIITCR 1778
Query: 419 ASLKGG---------------------------GISDISIDVNISSSTVPPNLTVPQEKS 451
A+ K G G+ I ++ +T Q++
Sbjct: 1779 ATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEK 1838
Query: 452 ----------PLVTREGDTIELQCQVTGKPKPIILW 477
P+ EG+T +C+VTG P+P + W
Sbjct: 1839 QKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNW 1874
Score = 31.6 bits (70), Expect = 3.7
Identities = 28/103 (27%), Positives = 43/103 (41%), Gaps = 8/103 (7%)
Query: 234 RLSNKTASPSIKLLVDDPIVVNPGEAITL-VCVTTGGEPAPSLTWVRSFGTLPEKTVLNG 292
+ ++ P I+L D VV TL + V G PAP + W R G +K +
Sbjct: 21850 KAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIES 21909
Query: 293 GT----LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRAL 331
+ L + + D+G Y N+ G+ KS + VR L
Sbjct: 21910 TSSYTLLIVGNVNRFDSGKYILTVENSSGS---KSAFVNVRVL 21949
Score = 31.6 bits (70), Expect = 3.7
Identities = 21/92 (22%), Positives = 41/92 (44%), Gaps = 6/92 (6%)
Query: 46 SERVYTIREGETLELTCLVTGHPRPQIRW--TKTAGSASDRFQDSSVFNE-TLRITNIQR 102
+ ++ T + G + ++G P P++ W + +DR ++ + TL + + R
Sbjct: 28653 TNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMR 28712
Query: 103 HQGGRYYCKAENGLGSPAIKSIRVDVYYLDDP 134
GRY+ EN G +K+ V V + P
Sbjct: 28713 GDSGRYFLTLENTAG---VKTFSVTVVVIGRP 28741
Score = 31.2 bits (69), Expect = 4.8
Identities = 14/31 (45%), Positives = 20/31 (64%), Gaps = 1/31 (3%)
Query: 453 LVTREGDTIELQCQVTGKPKPIILWSRADKE 483
L + GDTI L+ V GKP P + W++ DK+
Sbjct: 18211 LTVKAGDTIRLEAGVRGKPFPEVAWTK-DKD 18240
Score = 30.8 bits (68), Expect = 6.3
Identities = 18/59 (30%), Positives = 26/59 (44%), Gaps = 8/59 (13%)
Query: 437 SSTVPPNLTVPQEKSPLV-------TREGDTIELQCQVTGKPKPIILWSRADKEVAMPD 488
S PP V +P V + GD I L ++G P P I W + D+ V +P+
Sbjct: 14666 SRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWIK-DENVIVPE 14723
Score = 30.8 bits (68), Expect = 6.3
Identities = 29/93 (31%), Positives = 42/93 (45%), Gaps = 9/93 (9%)
Query: 242 PSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL------NGGTL 295
P+ KLL + V GE + V V G P P++TW + L + T + N L
Sbjct: 22148 PAFKLLFNT-FTVLAGEDLK-VDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLL 22205
Query: 296 TIPAITSDDAGTYSCIANNNVGNPAKKSTNIIV 328
TI +D G Y N+ G A ++ N+IV
Sbjct: 22206 TIKDACREDVGHYVVKLTNSAGE-AIETLNVIV 22237
Score = 30.8 bits (68), Expect = 6.3
Identities = 27/93 (29%), Positives = 42/93 (45%), Gaps = 7/93 (7%)
Query: 45 YSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDR---FQDSSVFNETLRITNIQ 101
Y+E V R G +++L ++G P P I W K +++ ++ I +
Sbjct: 26878 YTE-VVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDAD 26936
Query: 102 RHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDP 134
R G Y K N +GS A +IRV + LD P
Sbjct: 26937 RLNSGCYELKLRNAMGS-ASATIRVQI--LDKP 26966
Score = 30.4 bits (67), Expect = 8.2
Identities = 38/182 (20%), Positives = 70/182 (38%), Gaps = 28/182 (15%)
Query: 43 ERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFN---ETLRITN 99
ER+ + V T++EG+T +TC + P + W + + + + L I +
Sbjct: 8748 ERHLQDV-TLKEGQTCTMTCQFS-VPNVKSEWFRNGRILKPQGRHKTEVEHKVHKLTIAD 8805
Query: 100 IQRHQGGRYYCKAENGLGSPAIKSIRVDVYY---LDDPVVTVHQSIGEAKEQFYYERTVF 156
++ G+Y CK E+ S ++ + + + + VV+ HQS E + + V
Sbjct: 8806 VRAEDQGQYTCKYEDLETSAELRIEAEPIQFTKRIQNIVVSEHQSATFECEVSFDDAIV- 8864
Query: 157 LRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSC 216
+W +G L + F G + + N+ P D YS
Sbjct: 8865 -------------TWYKGPTELTESQKYN------FRNDGRCHYMTIHNVTPDDEGVYSV 8905
Query: 217 IA 218
IA
Sbjct: 8906 IA 8907
Score = 30.4 bits (67), Expect = 8.2
Identities = 22/98 (22%), Positives = 42/98 (42%), Gaps = 2/98 (2%)
Query: 418 VASLKGGGISDIS-IDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIIL 476
V ++ G+S+ S I N+ + T+ E ++ EG+ + + P P +
Sbjct: 14360 VRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVS 14419
Query: 477 WSRADKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMY 513
W + KEV D +M+ + L + R +G+Y
Sbjct: 14420 WHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIY 14457
Score = 30.4 bits (67), Expect = 8.2
Identities = 29/121 (23%), Positives = 54/121 (44%), Gaps = 20/121 (16%)
Query: 352 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 411
G ++ I AVP T SW K+G+ +++S+R +T + +S +L++ D
Sbjct: 14401 GEKLSIPVPFRAVPVP--TVSWHKDGKEVKASDR--LTMKNDHIS---AHLEVPKSVRAD 14453
Query: 412 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLV-TREGDTIELQCQVTGK 470
G YT I+++ + S+T N+ V P + D + C++T +
Sbjct: 14454 AGIYT------------ITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWE 14501
Query: 471 P 471
P
Sbjct: 14502 P 14502
Score = 30.4 bits (67), Expect = 8.2
Identities = 34/171 (19%), Positives = 71/171 (41%), Gaps = 19/171 (11%)
Query: 563 VLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAV-KSLSNENYGVYNCSIINEAGAGR 621
++R P +T+ + ++R GQ D + + V + + ++ G Y+ +++N AG
Sbjct: 18629 IVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKA 18688
Query: 622 CSFLVTGKAYAPEFYYDTYNPVWQNRHRVY---SYSLQWTQMNPDAVDRIVAYRLGIRQA 678
V DT PV + S + W D ++ Y + R+A
Sbjct: 18689 VFVNVR--------VLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREA 18740
Query: 679 GQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDST 729
++ W + ++K ++++T L+ Y R+T + ++G G T
Sbjct: 18741 DRKTW----STVTPEVKK---TSFHVTNLVPGNEYYFRVTAVNEYGPGVPT 18784
Score = 30.4 bits (67), Expect = 8.2
Identities = 19/70 (27%), Positives = 34/70 (48%), Gaps = 7/70 (10%)
Query: 349 IQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLK 408
++IG V + + P + SW K+G PL+ SE + ++T+ ++ L I + K
Sbjct: 27575 VRIGHNVHLELPYKGKPKPSI--SWLKDGLPLKESEFVRFSKTENKIT-----LSIKNAK 27627
Query: 409 FTDFGTYTCV 418
G YT +
Sbjct: 27628 KEHGGKYTVI 27637
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 123 bits (308), Expect = 9e-28
Identities = 160/710 (22%), Positives = 271/710 (38%), Gaps = 96/710 (13%)
Query: 54 EGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNE-TLRITNIQRH-QGGRYYCK 111
E + + L C G+P P RW + N L + N R+ G Y C
Sbjct: 42 EDKKITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCF 101
Query: 112 AENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPP----- 166
A N LG+ + ++ YL++ + ++ + Q V L C PP
Sbjct: 102 ATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQ-----GVVLLC----GPPPHSGE 152
Query: 167 VRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIAS--VRN-- 222
+ Y+W + VE F ET L + + P D NY+C+ + V N
Sbjct: 153 LSYAW------IFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMVTNAR 206
Query: 223 VCNIPDKMVSFRLSNKTA--SPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRS 280
V P +V R P I++ + + G + L C G P P + W RS
Sbjct: 207 VLGSPTPLV-LRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFAL-GNPIPQINWRRS 264
Query: 281 FGTLPEKTVLN----GGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRF 336
G LP + + G L IP +DAG+Y CIA N+ G + + +GR
Sbjct: 265 DG-LPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRG-----------KNVARGRL 312
Query: 337 WITPDPYH----KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTD 392
P+ KD I + + C+ P ++ W KNG L ER TQ +
Sbjct: 313 TYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKP--SYRWLKNGAALVLEER---TQIE 367
Query: 393 PDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSP 452
L I +L TD G + C+A K G + S ++ + +S P+ + K
Sbjct: 368 NGA------LTISNLSVTDSGMFQCIAENKHGLVYS-SAELKVVASA--PDFSKNPMKKL 418
Query: 453 LVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGM 512
+ + G + L C+ P+ + W + D V + + DG L+I NV++ +G
Sbjct: 419 VQVQVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLN--DGGLKIANVTKADAGT 476
Query: 513 YRCQTSQYNGFNVKPREALVQLIVQYPPAV--EPAFLEIRQGQDRSVTMSCRVLRAYPIR 570
Y C G L+V P + P+ +++ G+ SV + C+V + P+
Sbjct: 477 YTCMAENQFG----KANGTTHLVVTEPTRITLAPSNMDVSVGE--SVILPCQV-QHDPLL 529
Query: 571 VLTYEWRLGNKLLRTGQFDSQEYT--------EYAVKSLSNENYGVYNCSIIN--EAGAG 620
+ + W N L + D + + ++++ ++ G Y C + ++ +
Sbjct: 530 DIIFTWYF-NGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSS 588
Query: 621 RCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQ 680
+V G PE V + + L W + D +++Y + R
Sbjct: 589 AADLIVRGSPGPPE-------NVKVDEITDTTAQLSWKE-GKDNHSPVISYSIQARTPFS 640
Query: 681 QRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTI 730
W Q + + G+ T + EL YE R+ K G G+ ++
Sbjct: 641 VGW--QTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSL 688
Score = 36.6 bits (83), Expect = 0.12
Identities = 19/71 (26%), Positives = 32/71 (45%)
Query: 47 ERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGG 106
+++ ++ G + L C PR W K S + + S + + L+I N+ + G
Sbjct: 416 KKLVQVQVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDGGLKIANVTKADAG 475
Query: 107 RYYCKAENGLG 117
Y C AEN G
Sbjct: 476 TYTCMAENQFG 486
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 121 bits (303), Expect = 4e-27
Identities = 145/579 (25%), Positives = 235/579 (40%), Gaps = 63/579 (10%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWTK---TAGSASDRFQDSSVFNETLRITNIQRHQGGR 107
T+ GET L+C V G + W + +++ R + + + +L I+ I GGR
Sbjct: 410 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRV--AQLADLSLEISGIIPTDGGR 467
Query: 108 YYCKAENGLGSPAIKSIRVDVYYL--DDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNP 165
Y C A N G R V+ L + P V++H S + F V + C A+ P
Sbjct: 468 YQCVASNANGVT-----RASVWLLVREAPQVSIHTS----SQHFSQGVEVKVSCSASGYP 518
Query: 166 PVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCN 225
SW R + L + S V+ QG + P+D NYSC A+ N
Sbjct: 519 TPHISWSRESQALQEDSRIHVDAQGTLIIQG---------VAPEDAGNYSCQAT--NEVG 567
Query: 226 IPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL- 284
+ V+ T PS+ V+ ++V GE LVC +G P P + W R +
Sbjct: 568 TDQETVTLYY---TDPPSVSA-VNAVVLVAVGEEAVLVCEASG-VPPPRVIWYRGGLEMI 622
Query: 285 --PEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDP 342
PE + + G L IPA DAGTY+C A N +G+ + + + A + +T P
Sbjct: 623 LAPEGS--SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQ-----LTELP 675
Query: 343 YHKDDNIQIGREVKISCQVEAVPSEELTFSWFK-NGRPLRSSERMVITQTDPDVSPGTTN 401
+D +++GR ++C+ P +T W + +G+PL R+ + P +
Sbjct: 676 --RDVTVELGRSALLACRATGRPPPTVT--WRRGDGQPL--GLRLGAGRGSRSRQPDSGV 729
Query: 402 LDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLV-TREGDT 460
L + D Y C A G + + I + PP + +P V EG
Sbjct: 730 LFFESVAPEDQAPYVCEARNVFGKVQAEAR--LIVTGHAPPQIA---SSAPTVRVLEGQP 784
Query: 461 IELQCQV-TGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQ 519
+ L C V G+P P W + + +P GS DG+L + +E +G Y C +
Sbjct: 785 VSLPCIVLAGRPLPERHWLKDGRP--LPPGSRHSIRADGSLHLDRALQEHAGRYSCVATN 842
Query: 520 YNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLG 579
G + V+L+VQ PP + P + ++ C V P +T+
Sbjct: 843 TAGSQHRD----VELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVPAPTITWTKETN 897
Query: 580 NKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAG 618
R ++ + + S ++ G Y C+ N G
Sbjct: 898 ALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVG 936
Score = 111 bits (277), Expect = 4e-24
Identities = 124/492 (25%), Positives = 192/492 (39%), Gaps = 64/492 (13%)
Query: 49 VYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRY 108
V + GE L C +G P P++ W + G + LRI Q G Y
Sbjct: 589 VVLVAVGEEAVLVCEASGVPPPRVIWYR--GGLEMILAPEGSSSGKLRIPAAQERDAGTY 646
Query: 109 YCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYE--RTVFLRCVANSNPP 166
C+A N LG S + + P +T E E R+ L C A PP
Sbjct: 647 TCRAVNELGDA---SAEIQLAVGHAPQLT------ELPRDVTVELGRSALLACRATGRPP 697
Query: 167 VRYSWRRGQEV---LLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNV 223
+WRRG L G+ +G +P ++ +L +++ P+D A Y C A
Sbjct: 698 PTVTWRRGDGQPLGLRLGAGRGSRSRQP-----DSGVLFFESVAPEDQAPYVCEAR---- 748
Query: 224 CNIPDKMVSFRLSNKTASPSIKLLVDDPIV-VNPGEAITLVCVTTGGEPAPSLTWVRSFG 282
N+ K+ + T ++ P V V G+ ++L C+ G P P W++
Sbjct: 749 -NVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGR 807
Query: 283 TLP---EKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWIT 339
LP ++ G+L + + AG YSC+A N G+ + ++V+ + I
Sbjct: 808 PLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQ-HRDVELVVQVPPR----IH 862
Query: 340 PDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDP--DVSP 397
P H N G + C VP+ +T W K E +T P +VS
Sbjct: 863 PTATHHITNE--GVPASLPCVASGVPAPTIT--WTK--------ETNALTSRGPHYNVSK 910
Query: 398 GTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPP-------NLTVPQEK 450
T L I D G Y C A+ G S ++ +S +T P N VP +
Sbjct: 911 EGTLL-IAQPSAQDAGAYVCTATNTVGFSSQ---EMRLSVNTKPRIHMNGSRNANVPLQ- 965
Query: 451 SPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMS 510
+ + G+ + L C+ G P P++ W++ D P + G+LR+ V S
Sbjct: 966 --VTAKAGEEVTLDCEAKGSPPPLVTWTK-DSRPVPPITNRYGLLPSGSLRLAQVQVGDS 1022
Query: 511 GMYRCQTSQYNG 522
G Y C S G
Sbjct: 1023 GHYECTASNPAG 1034
Score = 102 bits (253), Expect = 2e-21
Identities = 130/570 (22%), Positives = 217/570 (38%), Gaps = 82/570 (14%)
Query: 69 RPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKS--IRV 126
R Q+R + FQ+S N + I + + G Y C A + G+ K+ +
Sbjct: 340 RLQLRRGEARLGEERHFQESG--NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVT 397
Query: 127 DVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGV 186
D P V S GE T L C P +W R VL + +
Sbjct: 398 DPPPQLVPAPNVTVSPGE---------TAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVA 448
Query: 187 EIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKL 246
++ + L++ + P D Y C+AS N + R +P + +
Sbjct: 449 QLAD--------LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR-----EAPQVSI 495
Query: 247 LVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN---GGTLTIPAITSD 303
+ G + + C + G P P ++W R L E + ++ GTL I + +
Sbjct: 496 HTSSQHF-SQGVEVKVSC-SASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPE 553
Query: 304 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDN----IQIGREVKISC 359
DAG YSC A N VG + T + T P N + +G E + C
Sbjct: 554 DAGNYSCQATNEVGTDQETVT-----------LYYTDPPSVSAVNAVVLVAVGEEAVLVC 602
Query: 360 QVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVA 419
+ VP + W++ G M++ P+ S + L I + D GTYTC A
Sbjct: 603 EASGVPPPRVI--WYRGGL------EMILA---PEGS-SSGKLRIPAAQERDAGTYTCRA 650
Query: 420 SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSR 479
+ D S ++ ++ P +P++ + G + L C+ TG+P P + W R
Sbjct: 651 V---NELGDASAEIQLAVGHAPQLTELPRD---VTVELGRSALLACRATGRPPPTVTWRR 704
Query: 480 ADKE-----VAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQL 534
D + + GS + G L +V+ E Y C+ N F EA + +
Sbjct: 705 GDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEAR--NVFGKVQAEARLIV 762
Query: 535 IVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTG-----QFD 589
PP + + +R + + V++ C VL P+ W + L G + D
Sbjct: 763 TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLP--ERHWLKDGRPLPPGSRHSIRAD 820
Query: 590 SQEYTEYAVKSLSNENYGVYNCSIINEAGA 619
+ + A++ E+ G Y+C N AG+
Sbjct: 821 GSLHLDRALQ----EHAGRYSCVATNTAGS 846
Score = 102 bits (253), Expect = 2e-21
Identities = 126/508 (24%), Positives = 197/508 (38%), Gaps = 93/508 (18%)
Query: 54 EGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAE 113
+G ++++C +G+P P I W++ + + + + TL I + G Y C+A
Sbjct: 504 QGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQAT 563
Query: 114 NGLGSPAIKSIRVDVYYLDDPVVT-----VHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
N +G+ V +YY D P V+ V ++GE L C A+ PP R
Sbjct: 564 NEVGTD---QETVTLYYTDPPSVSAVNAVVLVAVGEE---------AVLVCEASGVPPPR 611
Query: 169 YSWRRGQ-EVLL--QGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCN 225
W RG E++L +GS G L++ + +D Y+C R V
Sbjct: 612 VIWYRGGLEMILAPEGSSSGK--------------LRIPAAQERDAGTYTC----RAVNE 653
Query: 226 IPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL- 284
+ D +L+ A +L D + V G + L C TG P P++TW R G
Sbjct: 654 LGDASAEIQLAVGHAPQLTELPRD--VTVELGRSALLACRATG-RPPPTVTWRRGDGQPL 710
Query: 285 ---------PEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGR 335
+ G L ++ +D Y C A N G ++ I+
Sbjct: 711 GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP--- 767
Query: 336 FWITPDPYHKDDNIQI--GREVKISCQVEA---VPSEELTFSWFKNGRPLRSSERMVITQ 390
P +++ G+ V + C V A +P W K+GRPL R I
Sbjct: 768 ----PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH----WLKDGRPLPPGSRHSIR- 818
Query: 391 TDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS-DISIDVNISSSTVPPNLTVPQE 449
+ G+ +LD + G Y+CVA+ G D+ + V VPP +
Sbjct: 819 -----ADGSLHLDRALQEHA--GRYSCVATNTAGSQHRDVELVVQ-----VPPR--IHPT 864
Query: 450 KSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREM 509
+ +T EG L C +G P P I W++ + G S +GTL I S +
Sbjct: 865 ATHHITNEGVPASLPCVASGVPAPTITWTK-ETNALTSRGPHYNVSKEGTLLIAQPSAQD 923
Query: 510 SGMYRCQTSQYNGF---------NVKPR 528
+G Y C + GF N KPR
Sbjct: 924 AGAYVCTATNTVGFSSQEMRLSVNTKPR 951
Score = 72.4 bits (176), Expect = 2e-12
Identities = 104/441 (23%), Positives = 163/441 (36%), Gaps = 87/441 (19%)
Query: 48 RVYTIREGETLELTCLVTGHPRPQIRWTKTAGS-----------ASDRFQDSSVFNETLR 96
R T+ G + L C TG P P + W + G + R DS V L
Sbjct: 676 RDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV----LF 731
Query: 97 ITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVF 156
++ Y C+A N G ++ + + + + ++ + Q V
Sbjct: 732 FESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQ-----PVS 786
Query: 157 LRCVANSNPPV-RYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYS 215
L C+ + P+ W + L GS + G L L + YS
Sbjct: 787 LPCIVLAGRPLPERHWLKDGRPLPPGSRHSIR------ADGS---LHLDRALQEHAGRYS 837
Query: 216 CIAS---------VRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVT 266
C+A+ V V +P ++ + TA+ I N G +L CV
Sbjct: 838 CVATNTAGSQHRDVELVVQVPPRI------HPTATHHI---------TNEGVPASLPCVA 882
Query: 267 TGGEPAPSLTWVRSFGTL----PEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKK 322
+G PAP++TW + L P V GTL I ++ DAG Y C A N VG +++
Sbjct: 883 SG-VPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQE 941
Query: 323 ---STNIIVRALKKGRFWITPDPYHKDDNIQI------GREVKISCQVEAVPSEELTFSW 373
S N R G ++ N+ + G EV + C+ + P +T W
Sbjct: 942 MRLSVNTKPRIHMNG---------SRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVT--W 990
Query: 374 FKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISD-ISID 432
K+ RP+ IT + G +L + ++ D G Y C AS G S +
Sbjct: 991 TKDSRPVPP-----ITNRYGLLPSG--SLRLAQVQVGDSGHYECTASNPAGSASHRYVLG 1043
Query: 433 VNISSSTVPPNLTVPQEKSPL 453
V +S P +L VP + L
Sbjct: 1044 VQGRTSWQPQSLPVPHHPACL 1064
>gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1542
Score = 116 bits (291), Expect = 9e-26
Identities = 72/178 (40%), Positives = 97/178 (54%), Gaps = 24/178 (13%)
Query: 745 EFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIET 803
E C FE G IC + QD D+FDWT+ T T NTGP D + G+ +G Y+YIE+
Sbjct: 227 ELQCNFETG-ICNWEQDAKDDFDWTRNQGPTP----TLNTGPMKDNTLGTAKGHYLYIES 281
Query: 804 SRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYC-FSFFYHMYGQHIGVLNVYLRL----K 858
S P+ + A LLSP+ + T+T C F F+YHM+G+ I L +Y R+ +
Sbjct: 282 SEPQAFQDSAALLSPILNA--------TDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSR 333
Query: 859 GQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 916
GQ LW GN+G RW H+NI FQ++ E G G GDIAIDD+S +
Sbjct: 334 GQL-----LWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMD 386
Score = 78.2 bits (191), Expect = 3e-14
Identities = 55/172 (31%), Positives = 86/172 (50%), Gaps = 20/172 (11%)
Query: 748 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIETSRP 806
C FE ++C + Q+ ++FDW ++++ T P AD + G+ G Y++I + P
Sbjct: 672 CDFEF-DLCSWKQEKDEDFDWNLKASSIP----AAGTEPAADHTLGNSSGHYIFINSLFP 726
Query: 807 RLEGEKARLLSPVFSIAPKNPYGPTNTAYC-FSFFYHMYGQHIGVLNVY-LRLKGQTTIE 864
+ AR+ SPV S KN C F YHMYG IG L + + + QT +
Sbjct: 727 QQPMRAARISSPVISKRSKN---------CKIIFHYHMYGNGIGALTLMQVSVTNQTKV- 776
Query: 865 NPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 916
L + + +G W ++++ FQL FEG G G GDIA+DD+ + E
Sbjct: 777 --LLNLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLTE 826
Score = 69.3 bits (168), Expect = 2e-11
Identities = 47/177 (26%), Positives = 88/177 (49%), Gaps = 21/177 (11%)
Query: 748 CGFEDGNICLFTQ-------DDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYM 799
C FE ++C + Q D++ F W + + + N P+ D + + +G+Y+
Sbjct: 455 CSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHG-EENHRPSVDHTQNTTDGWYL 513
Query: 800 YIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKG 859
Y ++S + G+ A +L+P+ S+ GP T F+ HM G +G L V ++
Sbjct: 514 YADSSNGKF-GDTADILTPIISLT-----GPKCTLV---FWTHMNGATVGSLQVLIK--- 561
Query: 860 QTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 916
+ + + LW+ +G +G +W A V + + Q++F RG GD+A+DD+S +
Sbjct: 562 KDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQD 618
Score = 55.1 bits (131), Expect = 3e-07
Identities = 40/166 (24%), Positives = 71/166 (42%), Gaps = 11/166 (6%)
Query: 748 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPR 807
C FE + F D+FDW + S + + + P + +G +M+I
Sbjct: 19 CDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSS 78
Query: 808 LEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPL 867
L + A+L SP FS T SF+++ YG +G + L ++ +
Sbjct: 79 L-WQVAKLQSPTFS--------QTGPGCILSFWFYNYGLSVGAAELQLHMENSHD-STVI 128
Query: 868 WSSSGNKGQRWNEAHVNIYPITS-FQLIFEGIRGPGIEGDIAIDDV 912
W N+G++W EA + + ++ F L + + +G AIDD+
Sbjct: 129 WRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDI 174
Score = 47.0 bits (110), Expect = 9e-05
Identities = 47/179 (26%), Positives = 74/179 (41%), Gaps = 24/179 (13%)
Query: 748 CGFE--DGN---ICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIE 802
C FE GN C TQD D+ DW S P++D + ++Y+
Sbjct: 1164 CNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALI-----PDSDHTPGSGQHFLYVN 1218
Query: 803 TSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFS--FFYHMYGQHIGVLNVYLRLKGQ 860
+S + EG AR+ + + P + C +FY + + +G+L VY +
Sbjct: 1219 SSGSK-EGSVARITT--------SKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESG 1269
Query: 861 TTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGEC 919
I +WS GNK W V + + F++ FE + IA+DD+S EC
Sbjct: 1270 LNIL--VWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTP-EC 1325
>gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 116 bits (291), Expect = 9e-26
Identities = 72/178 (40%), Positives = 97/178 (54%), Gaps = 24/178 (13%)
Query: 745 EFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIET 803
E C FE G IC + QD D+FDWT+ T T NTGP D + G+ +G Y+YIE+
Sbjct: 502 ELQCNFETG-ICNWEQDAKDDFDWTRNQGPTP----TLNTGPMKDNTLGTAKGHYLYIES 556
Query: 804 SRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYC-FSFFYHMYGQHIGVLNVYLRL----K 858
S P+ + A LLSP+ + T+T C F F+YHM+G+ I L +Y R+ +
Sbjct: 557 SEPQAFQDSAALLSPILNA--------TDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSR 608
Query: 859 GQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 916
GQ LW GN+G RW H+NI FQ++ E G G GDIAIDD+S +
Sbjct: 609 GQL-----LWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMD 661
Score = 78.6 bits (192), Expect = 3e-14
Identities = 55/172 (31%), Positives = 87/172 (50%), Gaps = 20/172 (11%)
Query: 748 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIETSRP 806
C FE ++C + Q+ ++FDW ++++ T P AD + G+ G Y++I++ P
Sbjct: 947 CDFEF-DLCSWKQEKDEDFDWNLKASSIP----AAGTEPAADHTLGNSSGHYIFIKSLFP 1001
Query: 807 RLEGEKARLLSPVFSIAPKNPYGPTNTAYC-FSFFYHMYGQHIGVLNVY-LRLKGQTTIE 864
+ AR+ SPV S KN C F YHMYG IG L + + + QT +
Sbjct: 1002 QQPMRAARISSPVISKRSKN---------CKIIFHYHMYGNGIGALTLMQVSVTNQTKV- 1051
Query: 865 NPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 916
L + + +G W ++++ FQL FEG G G GDIA+DD+ + E
Sbjct: 1052 --LLNLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLTE 1101
Score = 69.3 bits (168), Expect = 2e-11
Identities = 47/177 (26%), Positives = 88/177 (49%), Gaps = 21/177 (11%)
Query: 748 CGFEDGNICLFTQ-------DDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYM 799
C FE ++C + Q D++ F W + + + N P+ D + + +G+Y+
Sbjct: 730 CSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHG-EENHRPSVDHTQNTTDGWYL 788
Query: 800 YIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKG 859
Y ++S + G+ A +L+P+ S+ GP T F+ HM G +G L V ++
Sbjct: 789 YADSSNGKF-GDTADILTPIISLT-----GPKCTLV---FWTHMNGATVGSLQVLIK--- 836
Query: 860 QTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 916
+ + + LW+ +G +G +W A V + + Q++F RG GD+A+DD+S +
Sbjct: 837 KDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQD 893
Score = 55.1 bits (131), Expect = 3e-07
Identities = 40/166 (24%), Positives = 71/166 (42%), Gaps = 11/166 (6%)
Query: 748 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPR 807
C FE + F D+FDW + S + + + P + +G +M+I
Sbjct: 294 CDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSS 353
Query: 808 LEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPL 867
L + A+L SP FS T SF+++ YG +G + L ++ +
Sbjct: 354 L-WQVAKLQSPTFS--------QTGPGCILSFWFYNYGLSVGAAELQLHMENSHD-STVI 403
Query: 868 WSSSGNKGQRWNEAHVNIYPITS-FQLIFEGIRGPGIEGDIAIDDV 912
W N+G++W EA + + ++ F L + + +G AIDD+
Sbjct: 404 WRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDI 449
Score = 47.0 bits (110), Expect = 9e-05
Identities = 47/179 (26%), Positives = 74/179 (41%), Gaps = 24/179 (13%)
Query: 748 CGFE--DGN---ICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIE 802
C FE GN C TQD D+ DW S P++D + ++Y+
Sbjct: 1439 CNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALI-----PDSDHTPGSGQHFLYVN 1493
Query: 803 TSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFS--FFYHMYGQHIGVLNVYLRLKGQ 860
+S + EG AR+ + + P + C +FY + + +G+L VY +
Sbjct: 1494 SSGSK-EGSVARITT--------SKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESG 1544
Query: 861 TTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGEC 919
I +WS GNK W V + + F++ FE + IA+DD+S EC
Sbjct: 1545 LNIL--VWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTP-EC 1600
>gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 116 bits (291), Expect = 9e-26
Identities = 72/178 (40%), Positives = 97/178 (54%), Gaps = 24/178 (13%)
Query: 745 EFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIET 803
E C FE G IC + QD D+FDWT+ T T NTGP D + G+ +G Y+YIE+
Sbjct: 502 ELQCNFETG-ICNWEQDAKDDFDWTRSQGPTP----TLNTGPMKDNTLGTAKGHYLYIES 556
Query: 804 SRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYC-FSFFYHMYGQHIGVLNVYLRL----K 858
S P+ + A LLSP+ + T+T C F F+YHM+G+ I L +Y R+ +
Sbjct: 557 SEPQAFQDSAALLSPILNA--------TDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSR 608
Query: 859 GQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 916
GQ LW GN+G RW H+NI FQ++ E G G GDIAIDD+S +
Sbjct: 609 GQL-----LWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMD 661
Score = 78.6 bits (192), Expect = 3e-14
Identities = 55/172 (31%), Positives = 87/172 (50%), Gaps = 20/172 (11%)
Query: 748 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIETSRP 806
C FE ++C + Q+ ++FDW ++++ T P AD + G+ G Y++I++ P
Sbjct: 947 CDFEF-DLCSWKQEKDEDFDWNLKASSIP----AAGTEPAADHTLGNSSGHYIFIKSLFP 1001
Query: 807 RLEGEKARLLSPVFSIAPKNPYGPTNTAYC-FSFFYHMYGQHIGVLNVY-LRLKGQTTIE 864
+ AR+ SPV S KN C F YHMYG IG L + + + QT +
Sbjct: 1002 QQPMRAARISSPVISKRSKN---------CKIIFHYHMYGNGIGALTLMQVSVTNQTKV- 1051
Query: 865 NPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 916
L + + +G W ++++ FQL FEG G G GDIA+DD+ + E
Sbjct: 1052 --LLNLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLTE 1101
Score = 69.3 bits (168), Expect = 2e-11
Identities = 47/177 (26%), Positives = 88/177 (49%), Gaps = 21/177 (11%)
Query: 748 CGFEDGNICLFTQ-------DDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYM 799
C FE ++C + Q D++ F W + + + N P+ D + + +G+Y+
Sbjct: 730 CSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHG-EENHRPSVDHTQNTTDGWYL 788
Query: 800 YIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKG 859
Y ++S + G+ A +L+P+ S+ GP T F+ HM G +G L V ++
Sbjct: 789 YADSSNGKF-GDTADILTPIISLT-----GPKCTLV---FWTHMNGATVGSLQVLIK--- 836
Query: 860 QTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 916
+ + + LW+ +G +G +W A V + + Q++F RG GD+A+DD+S +
Sbjct: 837 KDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQD 893
Score = 55.1 bits (131), Expect = 3e-07
Identities = 40/166 (24%), Positives = 71/166 (42%), Gaps = 11/166 (6%)
Query: 748 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPR 807
C FE + F D+FDW + S + + + P + +G +M+I
Sbjct: 294 CDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSS 353
Query: 808 LEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPL 867
L + A+L SP FS T SF+++ YG +G + L ++ +
Sbjct: 354 L-WQVAKLQSPTFS--------QTGPGCILSFWFYNYGLSVGAAELQLHMENSHD-STVI 403
Query: 868 WSSSGNKGQRWNEAHVNIYPITS-FQLIFEGIRGPGIEGDIAIDDV 912
W N+G++W EA + + ++ F L + + +G AIDD+
Sbjct: 404 WRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDI 449
Score = 47.0 bits (110), Expect = 9e-05
Identities = 47/179 (26%), Positives = 74/179 (41%), Gaps = 24/179 (13%)
Query: 748 CGFE--DGN---ICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIE 802
C FE GN C TQD D+ DW S P++D + ++Y+
Sbjct: 1439 CNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALI-----PDSDHTPGSGQHFLYVN 1493
Query: 803 TSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFS--FFYHMYGQHIGVLNVYLRLKGQ 860
+S + EG AR+ + + P + C +FY + + +G+L VY +
Sbjct: 1494 SSGSK-EGSVARITT--------SKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESG 1544
Query: 861 TTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGEC 919
I +WS GNK W V + + F++ FE + IA+DD+S EC
Sbjct: 1545 LNIL--VWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTP-EC 1600
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 114 bits (286), Expect = 3e-25
Identities = 135/541 (24%), Positives = 198/541 (36%), Gaps = 67/541 (12%)
Query: 56 ETLELTCLVTGHPRPQIRW----TKTAGSASDRFQDSSVFNETLRITNIQRHQ-GGRYYC 110
E + L C P RW T+ R Q + L I N + Q G Y C
Sbjct: 55 EQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQ---LVGGNLVIMNPTKAQDAGVYQC 111
Query: 111 KAENGLGSPAIKSIRVDVYYLD-------DPVVTVHQSIGEAKEQFYYERTVFLRCVANS 163
A N +G+ + + +L DPV H+ G V L C
Sbjct: 112 LASNPVGTVVSREAILRFGFLQEFSKEERDPV-KAHEGWG-----------VMLPC---- 155
Query: 164 NPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNV 223
NPP Y LL + F T L + D NYSC+A+
Sbjct: 156 NPPAHYPGL-SYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMD 214
Query: 224 CNIPDKMVSFRLSNKTA------SPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTW 277
+ F N A +PSIK G+ +TL C G P P + W
Sbjct: 215 FSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGN-PVPRIKW 273
Query: 278 VRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFW 337
+ G+L + TL IP+++ +D GTY C A N+ G + IIV+A + W
Sbjct: 274 RKVDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQG-RIIVQAQPE---W 329
Query: 338 ITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSP 397
+ D IG ++ C P T W +NG PL S R+ + D
Sbjct: 330 L---KVISDTEADIGSNLRWGCAAAGKPRP--TVRWLRNGEPLASQNRVEVLAGD----- 379
Query: 398 GTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTRE 457
L L D G Y CVA K G I ++ + P+ + + +
Sbjct: 380 ----LRFSKLSLEDSGMYQCVAENKHG---TIYASAELAVQALAPDFRLNPVRRLIPAAR 432
Query: 458 GDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQT 517
G I + CQ PK ++LWS+ + + + S + DGTL I N+SR G Y C
Sbjct: 433 GGEILIPCQPRAAPKAVVLWSKGTE--ILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFA 490
Query: 518 SQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWR 577
+ G ++ + + P+ +I G ++T+ C P LT+ W
Sbjct: 491 ENFMG--KANSTGILSVRDATKITLAPSSADINLGD--NLTLQCHASHD-PTMDLTFTWT 545
Query: 578 L 578
L
Sbjct: 546 L 546
Score = 80.9 bits (198), Expect = 5e-15
Identities = 96/381 (25%), Positives = 153/381 (40%), Gaps = 40/381 (10%)
Query: 44 RYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRH 103
R+ Y + G+ + L C G+P P+I+W K GS S ++ + TL+I ++
Sbjct: 244 RFPAETYAL-VGQQVTLECFAFGNPVPRIKWRKVDGSLSPQW---TTAEPTLQIPSVSFE 299
Query: 104 QGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANS 163
G Y C+AEN G ++ R+ V + + + + + + C A
Sbjct: 300 DEGTYECEAENSKGRDTVQG-RIIVQAQPEWLKVISDTEADIGSNLRW------GCAAAG 352
Query: 164 NPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNV 223
P W R E L S VE+ G+ L+ L +D Y C+A ++
Sbjct: 353 KPRPTVRWLRNGEPL--ASQNRVEV-----LAGD---LRFSKLSLEDSGMYQCVAENKH- 401
Query: 224 CNIPDKMVSFRLSNKTASPSIKL-LVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFG 282
S L+ + +P +L V I G I + C P + W +
Sbjct: 402 ---GTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAA-PKAVVLWSKGTE 457
Query: 283 TLPEK---TVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNII-VRALKKGRFWI 338
L TV GTL I I+ D G Y+C A N +G ST I+ VR K I
Sbjct: 458 ILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGK--ANSTGILSVRDATK----I 511
Query: 339 TPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPG 398
T P D I +G + + C P+ +LTF+W + P+ ++ +V
Sbjct: 512 TLAPSSAD--INLGDNLTLQCHASHDPTMDLTFTWTLDDFPI-DFDKPGGHYRRTNVKET 568
Query: 399 TTNLDIIDLKFTDFGTYTCVA 419
+L I++ + G YTC+A
Sbjct: 569 IGDLTILNAQLRHGGKYTCMA 589
Score = 80.1 bits (196), Expect = 9e-15
Identities = 109/493 (22%), Positives = 177/493 (35%), Gaps = 77/493 (15%)
Query: 152 ERTVFLRCVANSNPPVRYSWR-RGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQD 210
E V L C A ++PP Y W+ G E+ L+ + + TK QD
Sbjct: 54 EEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTK--------AQD 105
Query: 211 YANYSCIAS--VRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTG 268
Y C+AS V V + + ++ F + + DP+ + G + L C
Sbjct: 106 AGVYQCLASNPVGTVVS-REAILRFGFLQEFSKEE-----RDPVKAHEGWGVMLPCNPPA 159
Query: 269 GEPAPSLTWVRSFGTLPEKTVLNG--------GTLTIPAITSDDAGTYSCIANNNVG--- 317
P S W+ P +G G L I + D G YSC+A +++
Sbjct: 160 HYPGLSYRWL--LNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFST 217
Query: 318 ----------NPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSE 367
N A + T + ++K + + A+ +
Sbjct: 218 KSVFSKFAQLNLAAEDTRLFAPSIK----------------------ARFPAETYALVGQ 255
Query: 368 ELTFSWFKNGRPL-RSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGI 426
++T F G P+ R R V P + L I + F D GTY C A G
Sbjct: 256 QVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKG-- 313
Query: 427 SDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAM 486
++ I P L V + + G + C GKP+P + W R + +A
Sbjct: 314 -RDTVQGRIIVQAQPEWLKVISDTEADI---GSNLRWGCAAAGKPRPTVRWLRNGEPLAS 369
Query: 487 PDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAF 546
+ ++E G LR +S E SGMY+C +G E VQ + + P
Sbjct: 370 QN---RVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAP-DFRLNPVR 425
Query: 547 LEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL-RTGQFDSQEYTEYAVKSLSNEN 605
I + + + C+ RA P V+ W G ++L + + ++++S +
Sbjct: 426 RLIPAARGGEILIPCQP-RAAPKAVVL--WSKGTEILVNSSRVTVTPDGTLIIRNISRSD 482
Query: 606 YGVYNCSIINEAG 618
G Y C N G
Sbjct: 483 EGKYTCFAENFMG 495
Score = 65.9 bits (159), Expect = 2e-10
Identities = 88/366 (24%), Positives = 140/366 (38%), Gaps = 43/366 (11%)
Query: 290 LNGGTLTIPAIT-SDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDN 348
L GG L I T + DAG Y C+A+N VG + + L++ + K++
Sbjct: 90 LVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQE---------FSKEER 140
Query: 349 IQI----GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDI 404
+ G V + C A L++ W N P + T VS T NL I
Sbjct: 141 DPVKAHEGWGVMLPCNPPA-HYPGLSYRWLLNEFP-----NFIPTDGRHFVSQTTGNLYI 194
Query: 405 IDLKFTDFGTYTCVAS--LKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTRE----G 458
+D G Y+C+A+ + S S ++ + L P K+ G
Sbjct: 195 ARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVG 254
Query: 459 DTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTS 518
+ L+C G P P I W + D + S Q + + TL+I +VS E G Y C+
Sbjct: 255 QQVTLECFAFGNPVPRIKWRKVDGSL-----SPQWTTAEPTLQIPSVSFEDEGTYECEAE 309
Query: 519 QYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVL-TYEWR 577
G + +VQ +P +L++ + + + R A + T W
Sbjct: 310 NSKGRDTVQGRIIVQ--------AQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWL 361
Query: 578 LGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYY 637
+ L + + LS E+ G+Y C N+ G S + +A AP+F
Sbjct: 362 RNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDF-- 419
Query: 638 DTYNPV 643
NPV
Sbjct: 420 -RLNPV 424
Score = 55.1 bits (131), Expect = 3e-07
Identities = 67/286 (23%), Positives = 107/286 (37%), Gaps = 35/286 (12%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAEN 114
G L C G PRP +RW + + + + V LR + + G Y C AEN
Sbjct: 341 GSNLRWGCAAAGKPRPTVRWLRNGEPLASQNR-VEVLAGDLRFSKLSLEDSGMYQCVAEN 399
Query: 115 GLGSP-AIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRR 173
G+ A + V D + V + I A+ + + C + P W +
Sbjct: 400 KHGTIYASAELAVQALAPDFRLNPVRRLIPAARGG-----EILIPCQPRAAPKAVVLWSK 454
Query: 174 GQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSF 233
G E+L+ S V T T I++ N+ D Y+C A N K S
Sbjct: 455 GTEILVNSSRVTV-------TPDGTLIIR--NISRSDEGKYTCFAE-----NFMGKANST 500
Query: 234 RLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGG 293
+ + + I L +N G+ +TL C + +P LT+ + P GG
Sbjct: 501 GILSVRDATKITL-APSSADINLGDNLTLQCHASH-DPTMDLTFTWTLDDFPIDFDKPGG 558
Query: 294 ------------TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNII 327
LTI G Y+C+A V + +K++T ++
Sbjct: 559 HYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLV 604
>gi|139948432 adlican [Homo sapiens]
Length = 2828
Score = 114 bits (285), Expect = 4e-25
Identities = 153/633 (24%), Positives = 243/633 (38%), Gaps = 115/633 (18%)
Query: 51 TIREGETLELTCLVTGHPRPQIRWT-------KTAGSASDRFQDSSVFNETLRITNIQRH 103
T+ G+T+ + CL G P PQI W +T R N TL I
Sbjct: 1961 TVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHE--NRTLSIKEASFS 2018
Query: 104 QGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYER--TVFLRCVA 161
G Y C A N G+ ++ +IR+ V L PV+ HQ E E ++ + C A
Sbjct: 2019 DRGVYKCVASNAAGADSL-AIRLHVAALP-PVI--HQ---EKLENISLPPGLSIHIHCTA 2071
Query: 162 NSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKI-----LKLKNLRPQDYANYSC 216
+ P W G G +I F G + L ++NL P+D Y C
Sbjct: 2072 KAAPLPSVRWVLGD---------GTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYEC 2122
Query: 217 IASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLT 276
+A+ N+ + V + A+ I V G + L C + G+P P +
Sbjct: 2123 VAA--NLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDC-SASGDPWPRIL 2179
Query: 277 WVRSFGTLPEKTVLNG-------------GTLTIPAITSDDAGTYSCIANNNVGNP-AKK 322
W LP K +++ GTL + ++T DAG Y C+A N VG+
Sbjct: 2180 W-----RLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVL 2234
Query: 323 STNIIVRALKKGRFWITPDPYHKDDN---IQIGREVKISCQVEAVPSEELTFSWFKNGRP 379
+++++ K HK++N + G ++K+ C +P+ E+++S
Sbjct: 2235 KVDVVMKPAKIE---------HKEENDHKVFYGGDLKVDCVATGLPNPEISWSL------ 2279
Query: 380 LRSSERMVITQTDPDVSPGTTNLDII---------DLKFTDFGTYTCVASLKGGGISDIS 430
+V + D S G T ++ ++ + G YTC A + G
Sbjct: 2280 --PDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVG---KDE 2334
Query: 431 IDVNISSSTVPPNLTVPQEKSPLVTRE--GDTIELQCQVTGKPKPIILWSRADKEVAMPD 488
+ V + T P + + K+ L + GD + + C+ G+P P + W +V +P
Sbjct: 2335 MRVRVKVVTAPATI---RNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKV-IPT 2390
Query: 489 GSMQMESY-DGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYP-----PAV 542
S + + Y DGTL I R SG Y C G + K + + VQ P P
Sbjct: 2391 SSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRK--TVWIHVNVQPPKINGNPNP 2448
Query: 543 EPAFLEIRQGQDRSVTMSC--------RVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYT 594
EI G R + + C RVL A+P V+ GN++ G
Sbjct: 2449 ITTVREIAAGGSRKL-IDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGN------G 2501
Query: 595 EYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 627
++SL + C NE G R +T
Sbjct: 2502 SLDIRSLRKSDSVQLVCMARNEGGEARLILQLT 2534
Score = 109 bits (273), Expect = 1e-23
Identities = 156/641 (24%), Positives = 251/641 (39%), Gaps = 76/641 (11%)
Query: 28 TVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRF-- 85
TV++ A N S R +R G TL+L C +G P P+I W + D
Sbjct: 2134 TVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFS 2193
Query: 86 QDSSV---FNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSI 142
DS + N TL + ++ G Y C A N +G + ++VDV + P H+
Sbjct: 2194 FDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYV-VLKVDV--VMKPAKIEHKE- 2249
Query: 143 GEAKEQFYYERTVFLRCVANS--NPPVRYSWRRGQEV--LLQGSDKGVEIYEPFFTQGET 198
E + +Y + + CVA NP + +S G V +Q D G T
Sbjct: 2250 -ENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGT 2308
Query: 199 KILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGE 258
L + ++ +Y+C A + + + R+ TA +I+ + V G+
Sbjct: 2309 --LYFNEVGMREEGDYTCFAENQ----VGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGD 2362
Query: 259 AITLVCVTTGGEPAPSLTWV----RSFGTLPEK-TVLNGGTLTIPAITSDDAGTYSCIAN 313
+T+ C GEP P +TW+ + T EK + GTL I D+G Y+C+
Sbjct: 2363 VVTVAC-EAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVR 2421
Query: 314 NNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVK-ISCQVEAVPSEELTFS 372
N+ G K T I ++ + P+P I G K I C+ E +P+ + ++
Sbjct: 2422 NSAGEDRK--TVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWA 2479
Query: 373 WFKNGRPLRS---SERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDI 429
F G L + R+ + G +LDI L+ +D C+A +GG + +
Sbjct: 2480 -FPEGVVLPAPYYGNRITV--------HGNGSLDIRSLRKSDSVQLVCMARNEGGE-ARL 2529
Query: 430 SIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDG 489
+ + + P P + + G TI L C G P P ++W +P+G
Sbjct: 2530 ILQLTVLEPMEKPIFHDPISEK-ITAMAGHTISLNCSAAGTPTPSLVW-------VLPNG 2581
Query: 490 S-----MQMESY----DGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPP 540
+ Q++ + DG L I +S +G YRC G E LV L V P
Sbjct: 2582 TDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHT----ERLVSLKVGLKP 2637
Query: 541 AVEPAF---LEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKL-----LRTGQFDSQE 592
+ + I G+ ++ + C A R + W L N + G+ +
Sbjct: 2638 EANKQYHNLVSIINGE--TLKLPCTPPGAGQGR---FSWTLPNGMHLEGPQTLGRVSLLD 2692
Query: 593 YTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAP 633
V+ S + G Y C + E G S V AY P
Sbjct: 2693 NGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPP 2733
Score = 108 bits (271), Expect = 2e-23
Identities = 149/596 (25%), Positives = 225/596 (37%), Gaps = 78/596 (13%)
Query: 62 CLVTGHPRPQIRWTKTAGSA----SDRFQDSSVF-NETLRITNIQRHQGGRYYCKAENGL 116
C TG P+P + WTK + A + R Q V N TL I +Q G+Y C A N
Sbjct: 1875 CEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLH 1934
Query: 117 GSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQE 176
G + + + V ++ H Y T+ + C+A P + SW
Sbjct: 1935 GLDRM-VVLLSVTVQQPQILASHYQ----DVTVYLGDTIAMECLAKGTPAPQISWIFPDR 1989
Query: 177 VLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLS 236
+ Q V E T E + L +K D Y C+AS N ++ RL
Sbjct: 1990 RVWQ----TVSPVEGRITLHENRTLSIKEASFSDRGVYKCVAS--NAAGADS--LAIRLH 2041
Query: 237 NKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT-------- 288
P I + I + PG +I + C T P PS+ WV GT +
Sbjct: 2042 VAALPPVIHQEKLENISLPPGLSIHIHC-TAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF 2100
Query: 289 VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDN 348
V GTL I + D+G Y C+A N VG+ + + RA R T P D
Sbjct: 2101 VFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGT-SPRRTD-- 2157
Query: 349 IQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMV--ITQTDPDVSP-GTTNLDII 405
++ G +K+ C P + + S+RM+ + D + L +
Sbjct: 2158 VRYGGTLKLDCSASGDPWPRILWR--------LPSKRMIDALFSFDSRIKVFANGTLVVK 2209
Query: 406 DLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQC 465
+ D G Y CVA K + D + + + P + +E V GD +++ C
Sbjct: 2210 SVTDKDAGDYLCVARNK---VGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGD-LKVDC 2265
Query: 466 QVTGKPKPIILWSRADKEVAMPDGSMQ---MESYD-------------GTLRIVNVSREM 509
TG P P I WS +PDGS+ M+S D GTL V
Sbjct: 2266 VATGLPNPEISWS-------LPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMRE 2318
Query: 510 SGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV--EPAFLEIRQGQDRSVTMSCRVLRAY 567
G Y C G + E V++ V PA +L ++ VT++C +
Sbjct: 2319 EGDYTCFAENQVGKD----EMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEA-KGE 2373
Query: 568 PIRVLTYEWRLGNKLLRTGQFDSQEYTE--YAVKSLSNENYGVYNCSIINEAGAGR 621
P+ +T+ NK++ T Q Y + ++ + G Y C + N AG R
Sbjct: 2374 PMPKVTW-LSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDR 2428
Score = 105 bits (263), Expect = 2e-22
Identities = 125/493 (25%), Positives = 191/493 (38%), Gaps = 53/493 (10%)
Query: 55 GETLELTCLVTGHPRPQIRW----TKTAGSASDRFQDSSVFNE-TLRITNIQRHQGGRYY 109
G+ + + C G P P++ W K ++S+++Q ++ + TL I QR G Y
Sbjct: 2361 GDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQ---IYQDGTLLIQKAQRSDSGNYT 2417
Query: 110 CKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRY 169
C N G K++ + V + I +E + C A P R
Sbjct: 2418 CLVRNSAGEDR-KTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRV 2476
Query: 170 SWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDK 229
W + V+L G I T L +++LR D C+A RN
Sbjct: 2477 LWAFPEGVVLPAPYYGNRI-----TVHGNGSLDIRSLRKSDSVQLVCMA--RNEGGEARL 2529
Query: 230 MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGT------ 283
++ + P + + I G I+L C + G P PSL WV GT
Sbjct: 2530 ILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNC-SAAGTPTPSLVWVLPNGTDLQSGQ 2588
Query: 284 -LPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDP 342
L G L I ++S DAG Y C+A N G+ + + +LK G
Sbjct: 2589 QLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTER------LVSLKVGLKPEANKQ 2642
Query: 343 YHKDDNIQIGREVKISCQVEAVPSEELTFSW-FKNGRPLRSSERMVITQTDPDVSPGTTN 401
YH +I G +K+ C FSW NG L + + + GT
Sbjct: 2643 YHNLVSIINGETLKLPCTPPGAGQGR--FSWTLPNGMHLEGPQTLGRVSL---LDNGT-- 2695
Query: 402 LDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLV-TREGDT 460
L + + D GTY C + G S SI V + + PP +T E +P++ TR G+T
Sbjct: 2696 LTVREASVFDRGTYVCRMETEYGP-SVTSIPVIVIA--YPPRIT--SEPTPVIYTRPGNT 2750
Query: 461 IELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESY-------DGTLRIVNVSREMSGMY 513
++L C G PK I W DK + +Q Y G+L I + ++ +G Y
Sbjct: 2751 VKLNCMAMGIPKADITWELPDK--SHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFY 2808
Query: 514 RCQTSQYNGFNVK 526
+C G + K
Sbjct: 2809 KCMAKNILGSDSK 2821
Score = 88.2 bits (217), Expect = 3e-17
Identities = 120/533 (22%), Positives = 201/533 (37%), Gaps = 76/533 (14%)
Query: 43 ERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSS----------VFN 92
E E + + G L++ C+ TG P P+I W+ GS + F S VFN
Sbjct: 2246 EHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFN 2305
Query: 93 E-TLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYY 151
TL + + G Y C AEN +G +RV V + P +++ Q Y
Sbjct: 2306 NGTLYFNEVGMREEGDYTCFAENQVGK---DEMRVRVKVVTAPATIRNKTY--LAVQVPY 2360
Query: 152 ERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDY 211
V + C A P + +W ++ S + +IY + L ++ + D
Sbjct: 2361 GDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIY-------QDGTLLIQKAQRSDS 2413
Query: 212 ANYSCIASVRNVCNIPDKMVSFRLSNK----TASPSIKLLVDDPIVVNPGEAITLVCVTT 267
NY+C+ VRN K V ++ + +P+ V + + G + L+
Sbjct: 2414 GNYTCL--VRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVRE---IAAGGSRKLIDCKA 2468
Query: 268 GGEPAPSLTWVRSFG-TLPEK------TVLNGGTLTIPAITSDDAGTYSCIANNNVGNPA 320
G P P + W G LP TV G+L I ++ D+ C+A N G
Sbjct: 2469 EGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEAR 2528
Query: 321 KKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPL 380
++ ++K F DP + G + ++C P+ L + NG L
Sbjct: 2529 LILQLTVLEPMEKPIF---HDPISEKITAMAGHTISLNCSAAGTPTPSLVWV-LPNGTDL 2584
Query: 381 RSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISD-ISIDVNISSST 439
+S +++ D L I L D G Y CVA G +S+ V +
Sbjct: 2585 QSGQQLQRFYHKAD-----GMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPE- 2638
Query: 440 VPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMES---- 495
Q + + G+T++L C G + W+ +P+G M +E
Sbjct: 2639 -----ANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWT-------LPNG-MHLEGPQTL 2685
Query: 496 ------YDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV 542
+GTL + S G Y C+ G +V ++ +++ YPP +
Sbjct: 2686 GRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSV---TSIPVIVIAYPPRI 2735
Score = 74.7 bits (182), Expect = 4e-13
Identities = 99/404 (24%), Positives = 163/404 (40%), Gaps = 59/404 (14%)
Query: 245 KLLVDDPIVVN-PGEAITLVCVTTGGEPAPSLTWVR-SFGTLPEKT-------VLNGGTL 295
++L P V+ E T+ G+P P +TW + S G L VL GTL
Sbjct: 1854 QILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTL 1913
Query: 296 TIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREV 355
I + D G Y C A+N G + ++ +++ + + +++D + +G +
Sbjct: 1914 VIRKVQVQDRGQYMCTASNLHG--LDRMVVLLSVTVQQPQILAS---HYQDVTVYLGDTI 1968
Query: 356 KISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTT-----NLDIIDLKFT 410
+ C + P+ ++ SW R + QT V T L I + F+
Sbjct: 1969 AMECLAKGTPAPQI--SWIFPDRR--------VWQTVSPVEGRITLHENRTLSIKEASFS 2018
Query: 411 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVT-REGDTIELQCQVTG 469
D G Y CVAS G S+ + + + +PP + QEK ++ G +I + C
Sbjct: 2019 DRGVYKCVASNAAGA---DSLAIRLHVAALPP--VIHQEKLENISLPPGLSIHIHCTAKA 2073
Query: 470 KPKPIILWSRADKEVAMPDGSMQMESY---DGTLRIVNVSREMSGMYRCQTSQYNGFNVK 526
P P + W D P + + +GTL I N++ + SG Y C + G
Sbjct: 2074 APLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVG---- 2129
Query: 527 PREALVQLIVQYPPA------VEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGN 580
VQL VQ A P ++R G ++ + C R+L WRL +
Sbjct: 2130 SARRTVQLNVQRAAANARITGTSPRRTDVRYG--GTLKLDCSASGDPWPRIL---WRLPS 2184
Query: 581 KLLRTG--QFDSQ----EYTEYAVKSLSNENYGVYNCSIINEAG 618
K + FDS+ VKS+++++ G Y C N+ G
Sbjct: 2185 KRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVG 2228
Score = 59.7 bits (143), Expect = 1e-08
Identities = 43/131 (32%), Positives = 63/131 (48%), Gaps = 26/131 (19%)
Query: 201 LKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVV--NPGE 258
L++K++ P D Y CIA VR+ D+MV L SPS + D + + NPGE
Sbjct: 540 LRIKSMEPSDSGLYQCIAQVRDEM---DRMVYRVL---VQSPSTQPAEKDTVTIGKNPGE 593
Query: 259 AITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN------------GGTLTIPAITSDDAG 306
++TL C P L+W+ LP + ++N GTL+IP + D+G
Sbjct: 594 SVTLPCNALA-IPEAHLSWI-----LPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSG 647
Query: 307 TYSCIANNNVG 317
Y C+A N G
Sbjct: 648 YYRCVAVNQQG 658
Score = 57.8 bits (138), Expect = 5e-08
Identities = 49/206 (23%), Positives = 87/206 (42%), Gaps = 15/206 (7%)
Query: 442 PNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAM-PDGSMQMESY--DG 498
P + ++ VT E DT+ C+ TGKPKP + W++ M P+ +Q +G
Sbjct: 1853 PQILTKSPQTVSVTAETDTV-FPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG 1911
Query: 499 TLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVT 558
TL I V + G Y C S +G + L+ + VQ P + + ++ ++
Sbjct: 1912 TLVIRKVQVQDRGQYMCTASNLHGLD--RMVVLLSVTVQQPQILASHYQDVTVYLGDTIA 1969
Query: 559 MSCRVLRAYPIRVLTY------EWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCS 612
M C + + P +++ W+ + + G+ E ++K S + GVY C
Sbjct: 1970 MEC-LAKGTPAPQISWIFPDRRVWQTVSPV--EGRITLHENRTLSIKEASFSDRGVYKCV 2026
Query: 613 IINEAGAGRCSFLVTGKAYAPEFYYD 638
N AGA + + A P + +
Sbjct: 2027 ASNAAGADSLAIRLHVAALPPVIHQE 2052
Score = 47.4 bits (111), Expect = 7e-05
Identities = 49/199 (24%), Positives = 80/199 (40%), Gaps = 21/199 (10%)
Query: 440 VPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAM-----PDGSMQME 494
+ P+ V ++++ L EG +L C V P I W D + PD +
Sbjct: 479 IEPSGAVQRDQTVL---EGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSIL 535
Query: 495 SYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPA---FLEIRQ 551
S G LRI ++ SG+Y+C + + LVQ P+ +PA + I +
Sbjct: 536 S-SGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQ-----SPSTQPAEKDTVTIGK 589
Query: 552 GQDRSVTMSCRVLRAYPIRVLTY---EWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGV 608
SVT+ C L A P L++ R+ N L T ++ + + G
Sbjct: 590 NPGESVTLPCNAL-AIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGY 648
Query: 609 YNCSIINEAGAGRCSFLVT 627
Y C +N+ GA + +T
Sbjct: 649 YRCVAVNQQGADHFTVGIT 667
Score = 38.5 bits (88), Expect = 0.030
Identities = 49/199 (24%), Positives = 79/199 (39%), Gaps = 30/199 (15%)
Query: 257 GEAITLVCVTTGGEPAPSLTWVRSFGTL-------PEK--TVLNGGTLTIPAITSDDAGT 307
G L C E +PS+ WV G++ P+ ++L+ G L I ++ D+G
Sbjct: 494 GGPCQLSCNVKASE-SPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGL 552
Query: 308 YSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGR----EVKISCQVEA 363
Y CIA + ++ R L + + P K D + IG+ V + C A
Sbjct: 553 YQCIA-----QVRDEMDRMVYRVLVQSP---STQPAEK-DTVTIGKNPGESVTLPCNALA 603
Query: 364 VPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVA-SLK 422
+P L SW R + + + T L I ++ +D G Y CVA + +
Sbjct: 604 IPEAHL--SWILPNRRIIND----LANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQ 657
Query: 423 GGGISDISIDVNISSSTVP 441
G + I V S +P
Sbjct: 658 GADHFTVGITVTKKGSGLP 676
Score = 33.1 bits (74), Expect = 1.3
Identities = 22/77 (28%), Positives = 34/77 (44%), Gaps = 8/77 (10%)
Query: 49 VYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNE-------TLRITNIQ 101
+YT R G T++L C+ G P+ I W S + ++ +L I +
Sbjct: 2743 IYT-RPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHAT 2801
Query: 102 RHQGGRYYCKAENGLGS 118
+ G Y C A+N LGS
Sbjct: 2802 QRDAGFYKCMAKNILGS 2818
Score = 30.8 bits (68), Expect = 6.3
Identities = 23/80 (28%), Positives = 33/80 (41%), Gaps = 6/80 (7%)
Query: 40 IEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQD------SSVFNE 93
IE +R T+ EG +L+C V P I W GS D S + +
Sbjct: 479 IEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG 538
Query: 94 TLRITNIQRHQGGRYYCKAE 113
LRI +++ G Y C A+
Sbjct: 539 WLRIKSMEPSDSGLYQCIAQ 558
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 113 bits (282), Expect = 1e-24
Identities = 151/593 (25%), Positives = 242/593 (40%), Gaps = 87/593 (14%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAG--SASDRFQDSSVFNETLRITNIQRHQGGRYYCKA 112
G T+EL C +G+P P IRW K A R+ L I++++ G Y C+
Sbjct: 300 GHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT---GLTISDLRTEDSGTYICEV 356
Query: 113 ENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWR 172
N GS I + + DP +H ++ K + TV L C +P W
Sbjct: 357 TNTFGSAEATGILMVI----DP---LHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWY 409
Query: 173 RGQEVLLQGSDKGVEIYEPFFTQG-ETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMV 231
R E++L D+ + I +G + L + + + Y C A+ R D +
Sbjct: 410 RNTELVL--PDEAISI------RGLSNETLLITSAQKSHSGAYQCFAT-RKAQTAQDFAI 460
Query: 232 SFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTW-------VRSFG-- 282
++ + +P I + VVNPGE +L+C G P P++TW VR
Sbjct: 461 ---IALEDGTPRIVSSFSEK-VVNPGEQFSLMCAAKGA-PPPTVTWALDDEPIVRDGSHR 515
Query: 283 ----TLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWI 338
T+ + T ++ +T P I D G Y C A N VG+ A+ I VR
Sbjct: 516 TNQYTMSDGTTISHMNVTGPQIR--DGGVYRCTARNLVGS-AEYQARINVRG-------- 564
Query: 339 TPDPYHKDDNIQ--IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVS 396
P NI GR+ I+C+V P + W+K+ L + R V+ +
Sbjct: 565 -PPSIRAMRNITAVAGRDTLINCRVIGYP--YYSIKWYKDALLLPDNHRQVVFEN----- 616
Query: 397 PGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTR 456
GT L + K D G Y C ++ +SI ++ + P L P E P
Sbjct: 617 -GTLKLTDVQ-KGMDEGEYLCSVLIQ----PQLSISQSVHVAVKVPPLIQPFEFPP--AS 668
Query: 457 EGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMES--YDGTLRIVNVSREMSGMYR 514
G + + C V+ PI + R D +V + + +ES + +L+I +VS + +G Y
Sbjct: 669 IGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYT 728
Query: 515 CQTSQYNGFNVKPREALVQLIVQYPP--AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVL 572
C S N RE QLIV+ PP V+P + G ++ ++C V YP +
Sbjct: 729 CIAS--NAAATVSRER--QLIVRVPPRFVVQPNNQDGIYG--KAGVLNCSV-DGYPPPKV 781
Query: 573 TYEWRLG-------NKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAG 618
++ G + + TG+ + ++ + E+ G Y C N G
Sbjct: 782 MWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVG 834
Score = 80.9 bits (198), Expect = 5e-15
Identities = 126/547 (23%), Positives = 214/547 (39%), Gaps = 87/547 (15%)
Query: 45 YSERVYTIREGETLELTCLVTGHPRPQIRWT----KTAGSASDRFQDSSVFNET----LR 96
+SE+V + GE L C G P P + W S R ++ + T +
Sbjct: 474 FSEKV--VNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMN 531
Query: 97 ITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVF 156
+T Q GG Y C A N +GS ++ R++V P + ++I R
Sbjct: 532 VTGPQIRDGGVYRCTARNLVGSAEYQA-RINV--RGPPSIRAMRNITAVA-----GRDTL 583
Query: 157 LRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSC 216
+ C P W + +LL + + V F G K+ ++ + D Y C
Sbjct: 584 INCRVIGYPYYSIKWYK-DALLLPDNHRQV-----VFENGTLKLTDVQ--KGMDEGEYLC 635
Query: 217 IASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNP--------GEAITLVCVTTG 268
++ +I S S+ + V P ++ P G+ + + CV +
Sbjct: 636 SVLIQPQLSI--------------SQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSS 681
Query: 269 GEPAPSLTWVR--------SFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPA 320
G+ +TW + S T+ K ++ +L I +++ G Y+CIA+N
Sbjct: 682 GDMPIRITWRKDGQVIISGSGVTIESKEFMS--SLQISSVSLKHNGNYTCIASNAAAT-V 738
Query: 321 KKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPL 380
+ +IVR RF + P + D I G+ ++C V+ P ++ + K
Sbjct: 739 SRERQLIVRV--PPRFVVQP---NNQDGI-YGKAGVLNCSVDGYPPPKVMWKHAKGSGNP 792
Query: 381 RSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTV 440
+ + +T + P ++ L I + D G Y C AS G +DIS + + TV
Sbjct: 793 QQYHPVPLTGR-IQILPNSSLL-IRHVLEEDIGYYLCQAS--NGVGTDISKSMFL---TV 845
Query: 441 PPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQM------- 493
+ + + +G EL C G+ II W + D V PD M+
Sbjct: 846 KIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGD-TVIDPDRVMRYAIATKDN 904
Query: 494 -ESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQG 552
+ TL++ R S + C G + L+QL VQ PP +P LEIR+
Sbjct: 905 GDEVVSTLKLKPADRGDSVFFSCHAINSYGED----RGLIQLTVQEPP--DPPELEIREV 958
Query: 553 QDRSVTM 559
+ RS+ +
Sbjct: 959 KARSMNL 965
Score = 56.6 bits (135), Expect = 1e-07
Identities = 64/276 (23%), Positives = 109/276 (39%), Gaps = 26/276 (9%)
Query: 461 IELQCQVTGKPKPIILWSRADKEVAMP---DGSMQMESYDGTLRIVNVSREMSGMYRCQT 517
+ L C G P P + W++ ++ A+P DG + + +GTL + V E SG Y C
Sbjct: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT-NGTLLLRAVKAEDSGYYTCTA 1425
Query: 518 SQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWR 577
+ GF+ +V L+VQ PP + ++T IR ++
Sbjct: 1426 TNTGGFDT----IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYS 1481
Query: 578 LGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYY 637
+ N F S + + SL + + N G+GR S ++ K + E +
Sbjct: 1482 VDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSF 1541
Query: 638 DTYNPVWQNRHRVYSYSLQWTQMNPDAVDR----IVAYRLGIRQAGQQRWWEQEIKINGN 693
+++H + ++N + I A L R G W Q ++ N +
Sbjct: 1542 S------KDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAW--QGLRANSS 1593
Query: 694 IQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDST 729
GE+ LTEL + YE+R+ G G+ T
Sbjct: 1594 ---GEVF---LTELREATWYELRMRACNSAGCGNET 1623
Score = 36.2 bits (82), Expect = 0.15
Identities = 17/56 (30%), Positives = 30/56 (53%), Gaps = 7/56 (12%)
Query: 269 GEPAPSLTWVRSF--GTLP-----EKTVLNGGTLTIPAITSDDAGTYSCIANNNVG 317
G+PAP++ W + +P + + GTL + A+ ++D+G Y+C A N G
Sbjct: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
Score = 32.7 bits (73), Expect = 1.7
Identities = 49/218 (22%), Positives = 85/218 (38%), Gaps = 21/218 (9%)
Query: 415 YTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKP- 473
Y C A G I +I V + P + V ++S G+ +C + +
Sbjct: 161 YFCTAENAAGKIRSPNIRVK-AVFREPYTVRVEDQRS----MRGNVAVFKCLIPSSVQEY 215
Query: 474 --IILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMS-GMYRCQTS-QYNGFNVKPRE 529
++ W + D +P+ + +Y G L I +V +E + YRC T +Y+G +
Sbjct: 216 VSVVSWEK-DTVSIIPEHRFFI-TYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNG 273
Query: 530 ALVQLIVQYPPAVEPAFLEIRQGQD----RSVTMSCRVLRAYPIRVLTYEWRLGNKLLRT 585
A +L V P P L+ Q+ +V + C YPI + W + L
Sbjct: 274 A--RLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTA-SGYPIPAI--RWLKDGRPLPA 328
Query: 586 GQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCS 623
++ T + L E+ G Y C + N G+ +
Sbjct: 329 DSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEAT 366
>gi|81158226 neuronal cell adhesion molecule isoform A precursor
[Homo sapiens]
Length = 1304
Score = 112 bits (279), Expect = 2e-24
Identities = 125/462 (27%), Positives = 183/462 (39%), Gaps = 75/462 (16%)
Query: 26 PPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRF 85
PPT + G A N EE R G L L C+ G P P I W K G
Sbjct: 267 PPTF-LTPEGNASNKEELR----------GNVLSLECIAEGLPTPIIYWAKEDGMLPKNR 315
Query: 86 QDSSVFNETLRITNIQRHQGGRYYCKAENGLGS-PAIKSIRVDV--YYLDDPVVTVHQSI 142
F +TL+I ++ G Y C A+N LG+ S+RV Y++ P V S
Sbjct: 316 TVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLV-LSP 374
Query: 143 GEAKEQFYYERTVFLRCVANSNPPVRYSW-RRGQEVLLQGSDKGVEIYEPFFTQGETKIL 201
GE L C AN NP R SW G + + D +I G+T I
Sbjct: 375 GEDGT---------LICRANGNPKPRISWLTNGVPIEIAPDDPSRKI------DGDTIIF 419
Query: 202 KLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAIT 261
N++ + A Y C AS + L+N + +L + P ++ P +
Sbjct: 420 S--NVQERSSAVYQCNAS---------NEYGYLLANAF----VNVLAEPPRILTPANTLY 464
Query: 262 LVCVTTG--------GEPAPSLTWVRSF--GTLPEKTVL--NGGTLTIPAITSDDAGTYS 309
V G P P++ W + L E + GTL IP D GTY+
Sbjct: 465 QVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYT 524
Query: 310 CIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEEL 369
C+A N +G AK ++ + K WI P + +Q G V C+V+ + L
Sbjct: 525 CVARNKLG-MAKNEVHLEI----KDPTWIVKQPEYA--VVQRGSMVSFECKVKHDHTLSL 577
Query: 370 TFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDI 429
T W K+ R L S ER + D D +L + D+ D GTYTCVA+ +S
Sbjct: 578 TVLWLKDNRELPSDERFTV---DKD------HLVVADVSDDDSGTYTCVANTTLDSVSAS 628
Query: 430 SIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKP 471
++ +++ + T P P D ++ Q++ P
Sbjct: 629 AV-LSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTP 669
Score = 77.0 bits (188), Expect = 8e-14
Identities = 110/506 (21%), Positives = 181/506 (35%), Gaps = 73/506 (14%)
Query: 155 VFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYAN- 213
+ ++C A PP +SW R G+ ++ +P T + N+ + A
Sbjct: 64 IVIQCEAKGKPPPSFSWTRN------GTHFDID-KDPLVTMKPGTGTLIINIMSEGKAET 116
Query: 214 ----YSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGG 269
Y C A + + +V R S KL +PI + G+++ L C G
Sbjct: 117 YEGVYQCTARNERGAAVSNNIV-VRPSRSPLWTKEKL---EPITLQSGQSLVLPCRPPIG 172
Query: 270 EPAPSLTWV-RSFGTLPEKTV----LNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKST 324
P P + W+ SF LP+ LNG + D Y C A N ++
Sbjct: 173 LPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQ 232
Query: 325 NIIVRALKKGRF-------------------------WITPDPYHKDDNIQIGREVKISC 359
I V+ + ++TP+ + G + + C
Sbjct: 233 PISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLEC 292
Query: 360 QVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVA 419
E +P+ + W K L + R V + L II + D G Y C+A
Sbjct: 293 IAEGLPTPIIY--WAKEDGMLPKN-RTVYKNFEK-------TLQIIHVSEADSGNYQCIA 342
Query: 420 SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILW-- 477
G I +++ P +T PQ LV G+ L C+ G PKP I W
Sbjct: 343 KNALGAIHHT---ISVRVKAAPYWITAPQN---LVLSPGEDGTLICRANGNPKPRISWLT 396
Query: 478 SRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQ 537
+ E+A D S +++ T+ NV S +Y+C S G+ + A V ++ +
Sbjct: 397 NGVPIEIAPDDPSRKIDG--DTIIFSNVQERSSAVYQCNASNEYGYLL--ANAFVNVLAE 452
Query: 538 YPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNK--LLRTGQFDSQEYTE 595
P + PA + +R + C + + T EW G K L + E
Sbjct: 453 PPRILTPANTLYQVIANRPALLDCAF---FGSPLPTIEWFKGAKGSALHEDIYVLHENGT 509
Query: 596 YAVKSLSNENYGVYNCSIINEAGAGR 621
+ ++ G Y C N+ G +
Sbjct: 510 LEIPVAQKDSTGTYTCVARNKLGMAK 535
Score = 42.4 bits (98), Expect = 0.002
Identities = 45/170 (26%), Positives = 69/170 (40%), Gaps = 19/170 (11%)
Query: 345 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDI 404
KD I + I C+ + P +FSW +NG + ++T + PGT L I
Sbjct: 54 KDYIIDPRENIVIQCEAKGKPPP--SFSWTRNGTHFDIDKDPLVT-----MKPGTGTL-I 105
Query: 405 IDLKF-----TDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGD 459
I++ T G Y C A + G +I V S S L ++ P+ + G
Sbjct: 106 INIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSP----LWTKEKLEPITLQSGQ 161
Query: 460 TIELQCQ-VTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSRE 508
++ L C+ G P PII W + +P + +G L NV E
Sbjct: 162 SLVLPCRPPIGLPPPIIFWMDNSFQ-RLPQSERVSQGLNGDLYFSNVLPE 210
Score = 37.7 bits (86), Expect = 0.052
Identities = 25/101 (24%), Positives = 41/101 (40%), Gaps = 7/101 (6%)
Query: 428 DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAM- 486
++ +D + V P Q + + I +QC+ GKP P W+R +
Sbjct: 31 EVPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDID 90
Query: 487 PDGSMQMESYDGTLRIVNVSRE-----MSGMYRCQTSQYNG 522
D + M+ GTL I+N+ E G+Y+C G
Sbjct: 91 KDPLVTMKPGTGTL-IINIMSEGKAETYEGVYQCTARNERG 130
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 110 bits (276), Expect = 5e-24
Identities = 153/593 (25%), Positives = 231/593 (38%), Gaps = 85/593 (14%)
Query: 55 GETLELTCLVTGHPRPQIRWTK--TAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKA 112
G+ +EL C GHP P RW K S RFQ + L I NI+ G Y C+
Sbjct: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVT---GLLIENIRPSDSGSYVCEV 295
Query: 113 ENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWR 172
N G+ + + Y+ P + +I K + V L C SW
Sbjct: 296 SNRYGTAKV----IGRLYVKQP---LKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWY 348
Query: 173 RGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVS 232
R E+L G K V I T + L + ++ D Y C VR V
Sbjct: 349 RNGEILNPG--KNVRI-----TGINHENLIMDHMVKSDGGAYQCF--VRKDKLSAQDYVQ 399
Query: 233 FRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNG 292
L + T P I + VV+P E ++L+C G P P++TW TL + +L G
Sbjct: 400 VVLEDGT--PKIISAFSEK-VVSPAEPVSLMC-NVKGTPLPTITW-----TLDDDPILKG 450
Query: 293 GTLTI-PAITSD---------------DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRF 336
G+ I ITS+ D G Y C ANN+ G ++ R +G
Sbjct: 451 GSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQA-----RINVRGPA 505
Query: 337 WITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVS 396
I P K+ GR+ I C+V P + W+KN L + R V + +
Sbjct: 506 SIRP---MKNITAIAGRDTYIHCRVIGYP--YYSIKWYKNSNLLPFNHRQVAFENN---- 556
Query: 397 PGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTR 456
GT L + K D G YTC ++ + S+ V + VPP + P E
Sbjct: 557 -GTLKLSDVQ-KEVDEGEYTCNVLVQPQLSTSQSVHVTVK---VPPFIQ-PFEFPRFSI- 609
Query: 457 EGDTIELQCQVTGKPKPI-ILWSRADKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMYR 514
G + + C V PI I W + + + G ++ + +LRI N+S +G Y
Sbjct: 610 -GQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYT 668
Query: 515 CQTSQYNGFNVKPREALVQLIVQYPP--AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVL 572
C E QLIV+ PP V+P + G ++V ++C YP+ +
Sbjct: 669 CIARN----EAAAVEHQSQLIVRVPPKFVVQPRDQDGIYG--KAVILNCSA-EGYPVPTI 721
Query: 573 TYEWRLG------NKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGA 619
+++ G + G+ +K + E+ G Y C + N+ GA
Sbjct: 722 VWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGA 774
Score = 92.4 bits (228), Expect = 2e-18
Identities = 143/591 (24%), Positives = 237/591 (40%), Gaps = 67/591 (11%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAG--SASDRFQDSSVFNETLRITNIQRHQGGRYYCKA 112
G + L+C VTG ++ W + + + + + +E L + ++ + GG Y C
Sbjct: 328 GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFV 387
Query: 113 ENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWR 172
S A ++V L+D + + E + V L C P +W
Sbjct: 388 RKDKLS-AQDYVQV---VLEDGTPKIISAFSE--KVVSPAEPVSLMCNVKGTPLPTITWT 441
Query: 173 RGQEVLLQGSDKGVEIYEPFFTQGET-KILKLKNLRPQDYANYSCIASVRNVCNIPDKMV 231
+ +L+G I + ++G L + + + +D Y C A+ N ++
Sbjct: 442 LDDDPILKGGSH--RISQMITSEGNVVSYLNISSSQVRDGGVYRCTAN-----NSAGVVL 494
Query: 232 SFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP----EK 287
N SI+ + + I G + C G P S+ W ++ LP +
Sbjct: 495 YQARINVRGPASIRPMKN--ITAIAGRDTYIHCRVIG-YPYYSIKWYKNSNLLPFNHRQV 551
Query: 288 TVLNGGTLTIPAITSD-DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKD 346
N GTL + + + D G Y+C NV + ST+ V K +I P + +
Sbjct: 552 AFENNGTLKLSDVQKEVDEGEYTC----NVLVQPQLSTSQSVHVTVKVPPFIQPFEFPR- 606
Query: 347 DNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 406
IG+ V I C V + +T +W K+GRP+ S + I D T++L I +
Sbjct: 607 --FSIGQRVFIPCVVVS-GDLPITITWQKDGRPIPGSLGVTIDNID-----FTSSLRISN 658
Query: 407 LKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTV-PQEKSPLVTREGDTIELQC 465
L G YTC+A + + S + VPP V P+++ + G + L C
Sbjct: 659 LSLMHNGNYTCIARNEAAAVEHQSQLI----VRVPPKFVVQPRDQDGIY---GKAVILNC 711
Query: 466 QVTGKPKPIILWSRADKEVAMP-------DGSMQMESYDGTLRIVNVSREMSGMYRCQTS 518
G P P I+W + K +P +G +Q+ S +G+L I +V E SG Y C+ S
Sbjct: 712 SAEGYPVPTIVW-KFSKGAGVPQFQPIALNGRIQVLS-NGSLLIKHVVEEDSGYYLCKVS 769
Query: 519 QYNGFNVKPREALVQLIVQYPPAVE--PAFLEIRQGQDRSVTMSCRVLRAYPIRV-LTYE 575
G +V + L V+ P + P QGQ + MSC PI V E
Sbjct: 770 NDVGADVSKS---MYLTVKIPAMITSYPNTTLATQGQKKE--MSCTAHGEKPIIVRWEKE 824
Query: 576 WRLGNKLLRTGQFDSQEYTEYAVKSLS-----NENYGVYNCSIINEAGAGR 621
R+ N + ++E E + +L E+ G ++C IN G R
Sbjct: 825 DRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDR 875
Score = 82.0 bits (201), Expect = 2e-15
Identities = 126/546 (23%), Positives = 212/546 (38%), Gaps = 86/546 (15%)
Query: 45 YSERVYTIREGETLELTCLVTGHPRPQIRWT------KTAGS--ASDRFQDSSVFNETLR 96
+SE+V + E + L C V G P P I WT GS S L
Sbjct: 413 FSEKV--VSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLN 470
Query: 97 ITNIQRHQGGRYYCKAENGLGSPAIKS-IRVDVYYLDDPVVTVHQSIGEAKEQFYYERTV 155
I++ Q GG Y C A N G ++ I V P+ + G R
Sbjct: 471 ISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAG---------RDT 521
Query: 156 FLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYS 215
++ C P W + LL + + V F G K+ ++ + D Y+
Sbjct: 522 YIHCRVIGYPYYSIKWYKNSN-LLPFNHRQV----AFENNGTLKLSDVQ--KEVDEGEYT 574
Query: 216 CIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNP--------GEAITLVCVTT 267
C + +V +LS S S+ + V P + P G+ + + CV
Sbjct: 575 C-----------NVLVQPQLS---TSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVV 620
Query: 268 GGEPAPSLTWVRSFGTLPEK---TVLN---GGTLTIPAITSDDAGTYSCIANNNVGNPAK 321
G+ ++TW + +P T+ N +L I ++ G Y+CIA N +
Sbjct: 621 SGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAA-AVE 679
Query: 322 KSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLR 381
+ +IVR K F + P +D + G+ V ++C E P + + F G +
Sbjct: 680 HQSQLIVRVPPK--FVVQP----RDQDGIYGKAVILNCSAEGYPVPTIVWK-FSKGAGVP 732
Query: 382 SSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISS-STV 440
+ + + +S G +L I + D G Y C S +D+ DV+ S TV
Sbjct: 733 QFQPIALNGRIQVLSNG--SLLIKHVVEEDSGYYLCKVS------NDVGADVSKSMYLTV 784
Query: 441 PPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQM------- 493
+ + + +G E+ C G+ I+ W + D+ + P+ + +
Sbjct: 785 KIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDR-IINPEMARYLVSTKEVG 843
Query: 494 ESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQ 553
E TL+I+ RE SG + C G + ++QL VQ PP +P +EI+ +
Sbjct: 844 EEVISTLQILPTVREDSGFFSCHAINSYGED----RGIIQLTVQEPP--DPPEIEIKDVK 897
Query: 554 DRSVTM 559
R++T+
Sbjct: 898 ARTITL 903
Score = 47.4 bits (111), Expect = 7e-05
Identities = 83/380 (21%), Positives = 140/380 (36%), Gaps = 80/380 (21%)
Query: 213 NYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPA 272
N S I +V + P ++++F S +P +K +V P +A+ G+P+
Sbjct: 1271 NSSEIITVEPLAKAPARILTF--SGTVTTPWMK------DIVLPCKAV--------GDPS 1314
Query: 273 PSLTWVRSFGTLPEKTVLNG-------GTLTIPAITSDDAGTYSCIANNNVGNPAKKSTN 325
P++ W++ P ++G G+ I + ++D+G YSCIANNN G S
Sbjct: 1315 PAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG-----SDE 1369
Query: 326 IIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSER 385
II+ + + PD + V S +T SW G SS R
Sbjct: 1370 IILNL----QVQVPPD--------------QPRLTVSKTTSSSITLSWLP-GDNGGSSIR 1410
Query: 386 MVITQTDPD---------VSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNIS 436
I Q D +SP + + +LK + +T A G G IS +
Sbjct: 1411 GYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQ-NGVGPGRISEIIEAK 1469
Query: 437 SSTVPPNLTVPQEKSPLVTREGDTIEL------QCQVTG-----KPKPIILWSRADKEVA 485
+ P + QE + + L C +T +P +W+ A +
Sbjct: 1470 TLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSL 1529
Query: 486 MPD----GSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPA 541
+ Y+ +R+ N + T Y+G + P L++ +VQ
Sbjct: 1530 SKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPP---LIKSVVQNEEG 1586
Query: 542 VEPAFLEIRQGQDRSVTMSC 561
L +G VT+SC
Sbjct: 1587 -----LTTNEGLKMLVTISC 1601
Score = 37.0 bits (84), Expect = 0.088
Identities = 57/238 (23%), Positives = 94/238 (39%), Gaps = 25/238 (10%)
Query: 414 TYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKP 473
TY C A G I S DV+I + P +++ T G+ +C + +
Sbjct: 99 TYYCTAENPSGKIR--SQDVHIKAVLREPYTVRVEDQK---TMRGNVAVFKCIIPSSVEA 153
Query: 474 IILWSRADKE-VAMPDGSMQMESYDGTLRIVNVSREMSGMY--RCQTS-QYNGFNVKPRE 529
I +K+ V++ GS + + G L I +V E G+Y RC T +Y G +
Sbjct: 154 YITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNE-DGLYNYRCITRHRYTGETRQSNS 212
Query: 530 ALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVL-----TYEWRLGNKLLR 584
A +L V P P+ L+ G D M+ + + P + L Y W N L
Sbjct: 213 A--RLFVSDPANSAPSILD---GFDHRKAMAGQRVEL-PCKALGHPEPDYRWLKDNMPLE 266
Query: 585 TGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNP 642
+ T ++++ + G Y C + N G + V G+ Y + T +P
Sbjct: 267 LSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAK----VIGRLYVKQPLKATISP 320
Score = 32.0 bits (71), Expect = 2.8
Identities = 28/87 (32%), Positives = 42/87 (48%), Gaps = 6/87 (6%)
Query: 60 LTCLVTGHPRPQIRWTKTA-GSASDRFQDS--SVF-NETLRITNIQRHQGGRYYCKAENG 115
L C G P P ++W K + G+ S D S+F N + I ++ G Y C A N
Sbjct: 1305 LPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNN 1364
Query: 116 LGS-PAIKSIRVDVYYLDDPVVTVHQS 141
GS I +++V V D P +TV ++
Sbjct: 1365 WGSDEIILNLQVQV-PPDQPRLTVSKT 1390
>gi|81158224 neuronal cell adhesion molecule isoform B precursor
[Homo sapiens]
Length = 1183
Score = 110 bits (276), Expect = 5e-24
Identities = 122/432 (28%), Positives = 172/432 (39%), Gaps = 77/432 (17%)
Query: 26 PPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRF 85
PPT + G A N EE R G L L C+ G P P I W K G
Sbjct: 261 PPTF-LTPEGNASNKEELR----------GNVLSLECIAEGLPTPIIYWAKEDGMLPKNR 309
Query: 86 QDSSVFNETLRITNIQRHQGGRYYCKAENGLGS-PAIKSIRVDV--YYLDDPVVTVHQSI 142
F +TL+I ++ G Y C A+N LG+ S+RV Y++ P V S
Sbjct: 310 TVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLV-LSP 368
Query: 143 GEAKEQFYYERTVFLRCVANSNPPVRYSW-RRGQEVLLQGSDKGVEIYEPFFTQGETKIL 201
GE L C AN NP R SW G + + D +I G+T I
Sbjct: 369 GEDGT---------LICRANGNPKPRISWLTNGVPIEIAPDDPSRKI------DGDTIIF 413
Query: 202 KLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAIT 261
N++ + A Y C AS + L+N + +L + P ++ P +
Sbjct: 414 S--NVQERSSAVYQCNAS---------NEYGYLLANAF----VNVLAEPPRILTPANTLY 458
Query: 262 LVCVTTG--------GEPAPSLTWVRSF--GTLPEKTVL--NGGTLTIPAITSDDAGTYS 309
V G P P++ W + L E + GTL IP D GTY+
Sbjct: 459 QVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYT 518
Query: 310 CIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEEL 369
C+A N +G AK ++ + K WI P + +Q G V C+V+ + L
Sbjct: 519 CVARNKLG-MAKNEVHLEI----KDPTWIVKQPEYA--VVQRGSMVSFECKVKHDHTLSL 571
Query: 370 TFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDI 429
T W K+ R L S ER + D D +L + D+ D GTYTCVA+ + +
Sbjct: 572 TVLWLKDNRELPSDERFTV---DKD------HLVVADVSDDDSGTYTCVANTT---LDSV 619
Query: 430 SIDVNISSSTVP 441
S +S VP
Sbjct: 620 SASAVLSVVDVP 631
Score = 77.0 bits (188), Expect = 8e-14
Identities = 110/506 (21%), Positives = 181/506 (35%), Gaps = 73/506 (14%)
Query: 155 VFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYAN- 213
+ ++C A PP +SW R G+ ++ +P T + N+ + A
Sbjct: 58 IVIQCEAKGKPPPSFSWTRN------GTHFDID-KDPLVTMKPGTGTLIINIMSEGKAET 110
Query: 214 ----YSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGG 269
Y C A + + +V R S KL +PI + G+++ L C G
Sbjct: 111 YEGVYQCTARNERGAAVSNNIV-VRPSRSPLWTKEKL---EPITLQSGQSLVLPCRPPIG 166
Query: 270 EPAPSLTWV-RSFGTLPEKTV----LNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKST 324
P P + W+ SF LP+ LNG + D Y C A N ++
Sbjct: 167 LPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQ 226
Query: 325 NIIVRALKKGRF-------------------------WITPDPYHKDDNIQIGREVKISC 359
I V+ + ++TP+ + G + + C
Sbjct: 227 PISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLEC 286
Query: 360 QVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVA 419
E +P+ + W K L + R V + L II + D G Y C+A
Sbjct: 287 IAEGLPTPIIY--WAKEDGMLPKN-RTVYKNFEK-------TLQIIHVSEADSGNYQCIA 336
Query: 420 SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILW-- 477
G I +++ P +T PQ LV G+ L C+ G PKP I W
Sbjct: 337 KNALGAIHHT---ISVRVKAAPYWITAPQN---LVLSPGEDGTLICRANGNPKPRISWLT 390
Query: 478 SRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQ 537
+ E+A D S +++ T+ NV S +Y+C S G+ + A V ++ +
Sbjct: 391 NGVPIEIAPDDPSRKIDG--DTIIFSNVQERSSAVYQCNASNEYGYLL--ANAFVNVLAE 446
Query: 538 YPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNK--LLRTGQFDSQEYTE 595
P + PA + +R + C + + T EW G K L + E
Sbjct: 447 PPRILTPANTLYQVIANRPALLDCAF---FGSPLPTIEWFKGAKGSALHEDIYVLHENGT 503
Query: 596 YAVKSLSNENYGVYNCSIINEAGAGR 621
+ ++ G Y C N+ G +
Sbjct: 504 LEIPVAQKDSTGTYTCVARNKLGMAK 529
Score = 42.4 bits (98), Expect = 0.002
Identities = 45/170 (26%), Positives = 69/170 (40%), Gaps = 19/170 (11%)
Query: 345 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDI 404
KD I + I C+ + P +FSW +NG + ++T + PGT L I
Sbjct: 48 KDYIIDPRENIVIQCEAKGKPPP--SFSWTRNGTHFDIDKDPLVT-----MKPGTGTL-I 99
Query: 405 IDLKF-----TDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGD 459
I++ T G Y C A + G +I V S S L ++ P+ + G
Sbjct: 100 INIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSP----LWTKEKLEPITLQSGQ 155
Query: 460 TIELQCQ-VTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSRE 508
++ L C+ G P PII W + +P + +G L NV E
Sbjct: 156 SLVLPCRPPIGLPPPIIFWMDNSFQ-RLPQSERVSQGLNGDLYFSNVLPE 204
Score = 36.2 bits (82), Expect = 0.15
Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 8/88 (9%)
Query: 441 PPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAM-PDGSMQMESYDGT 499
PP +T K ++ + I +QC+ GKP P W+R + D + M+ GT
Sbjct: 39 PPTITQQSPKDYIIDPR-ENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGT 97
Query: 500 LRIVNVSRE-----MSGMYRCQTSQYNG 522
L I+N+ E G+Y+C G
Sbjct: 98 L-IINIMSEGKAETYEGVYQCTARNERG 124
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 109 bits (273), Expect = 1e-23
Identities = 122/514 (23%), Positives = 209/514 (40%), Gaps = 68/514 (13%)
Query: 43 ERYSERVYTIREGETLELTCLVTGHPRPQIRW-----TKTAGSASDRFQDSSVFNETLRI 97
ER ++ + T+ G T+EL C G P P + W T + S+ Q + TL +
Sbjct: 1749 ERRTKEI-TVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVL 1807
Query: 98 TNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQS----IGEAKEQFYYER 153
N+ + G Y C A N G S+ V + + P V + Q +G E
Sbjct: 1808 HNLSIYDRGFYKCVASNPGGQD---SLLVKIQVIAAPPVILEQRRQVIVGTWGE------ 1858
Query: 154 TVFLRCVANSNPPVRYSWRRGQEVLLQGSD-KGVEIYEPFFTQGETKILKLKNLRPQDYA 212
++ L C A P W VL G++ K ++ L ++NL D
Sbjct: 1859 SLKLPCTAKGTPQPSVYW-----VLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRG 1913
Query: 213 NYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPA 272
Y CIA+ + ++V + + SP I+ VN G+ + L C TG EP
Sbjct: 1914 TYECIAT--SSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATG-EPK 1970
Query: 273 PSLTWVRSFGTLPEKTVLN-------------GGTLTIPAITSDDAGTYSCIANNNVGNP 319
P + W LP K V++ G+L I ++T D+G Y C+A N +G+
Sbjct: 1971 PQIMW-----RLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGD- 2024
Query: 320 AKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKN--- 376
++ +L+ I Y + + G++ ++ C+ P E+++S
Sbjct: 2025 ---DLILMHVSLRLKPAKIDHKQYFRKQVLH-GKDFQVDCKASGSPVPEISWSLPDGTMI 2080
Query: 377 GRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNIS 436
+++ + T+ + GT + + + + G YTC A + + V+++
Sbjct: 2081 NNAMQADDSGHRTRRYTLFNNGTLYFNKVGV--AEEGDYTCYAQ---NTLGKDEMKVHLT 2135
Query: 437 SSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESY 496
T P + + + + + GDT L C+VTG PKP I W ++ S ++ Y
Sbjct: 2136 VITAAPRIRQSNKTNKRI-KAGDTAVLDCEVTGDPKPKIFWLLPSNDMI----SFSIDRY 2190
Query: 497 ----DGTLRIVNVSREMSGMYRCQTSQYNGFNVK 526
+G+L I V SG Y C +G + K
Sbjct: 2191 TFHANGSLTINKVKLLDSGEYVCVARNPSGDDTK 2224
Score = 109 bits (272), Expect = 1e-23
Identities = 119/482 (24%), Positives = 186/482 (38%), Gaps = 47/482 (9%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF--NETLRITNIQRHQGGRYY 109
I+ G+T L C VTG P+P+I W + D F N +L I ++ G Y
Sbjct: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYV 2212
Query: 110 CKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRY 169
C A N G K ++DV + ++ + K C A P
Sbjct: 2213 CVARNPSGDDT-KMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEV 2271
Query: 170 SWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDK 229
W + L G I T + L+++N+R D A++ C+A RN
Sbjct: 2272 MWIMPDNIFLTAPYYGSRI-----TVHKNGTLEIRNVRLSDSADFICVA--RNEGGESVL 2324
Query: 230 MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL----P 285
+V + P+ + ++ IV G++ L C + G P P + W+ GT P
Sbjct: 2325 VVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNC-SVDGNPPPEIIWILPNGTRFSNGP 2383
Query: 286 EK---TVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDP 342
+ + + G+ I T +DAG Y C A N VG K +++ + + +T P
Sbjct: 2384 QSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEK----LVILEIGQKPVILTYAP 2439
Query: 343 YHKDDNIQIGREVKISCQVEAVPSEELTF---SWFKNGRPLRSSERMVITQTDPDVSPGT 399
G + + C + +P + + S + RP + + ++ GT
Sbjct: 2440 GTVKGIS--GESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDN-------GT 2490
Query: 400 TNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGD 459
L I + D G Y C A + I V + PP +T +S +VTR G
Sbjct: 2491 --LVIKEATAYDRGNYICKAQ---NSVGHTLITVPVMIVAYPPRITNRPPRS-IVTRTGA 2544
Query: 460 TIELQCQVTGKPKPIILWSRADKEV------AMPDGSMQMESYDGTLRIVNVSREMSGMY 513
+L C G PKP I W D + GS Q+ GTL I N SG+Y
Sbjct: 2545 AFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLH-LQGTLVIQNPQTSDSGIY 2603
Query: 514 RC 515
+C
Sbjct: 2604 KC 2605
Score = 99.4 bits (246), Expect = 1e-20
Identities = 120/459 (26%), Positives = 185/459 (40%), Gaps = 54/459 (11%)
Query: 50 YTIREGETLELTCLVTGHPRPQIRWTKTAG--SASDRFQDSSVF---NETLRITNIQRHQ 104
+TI L C G+P P I WT+ S R Q+S V N TL I ++
Sbjct: 1658 FTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQD 1717
Query: 105 GGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQ---FYYERTVFLRCVA 161
G+Y C A N G+ D ++ VV+ I E + + + TV L+C A
Sbjct: 1718 RGQYLCSASNLFGT--------DHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRA 1769
Query: 162 NSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVR 221
P +W + ++ S +G + T T L L NL D Y C+AS
Sbjct: 1770 EGRPSPTVTWILANQTVVSESSQGSR--QAVVTVDGT--LVLHNLSIYDRGFYKCVAS-- 1823
Query: 222 NVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNP-GEAITLVCVTTGGEPAPSLTWVRS 280
N +V ++ A+P + L ++V GE++ L C T G P PS+ WV S
Sbjct: 1824 NPGGQDSLLVKIQV---IAAPPVILEQRRQVIVGTWGESLKLPC-TAKGTPQPSVYWVLS 1879
Query: 281 FGTLPEKT--------VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALK 332
GT + + + GTL I + S D GTY CIA ++ G+ + + +
Sbjct: 1880 DGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVT 1939
Query: 333 KGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTD 392
R K + G ++ ++C P ++ W + + + V +
Sbjct: 1940 SPRIEAAS---QKRTEVNFGDKLLLNCSATGEPKPQI--MWRLPSKAVVDQQHRVGSWI- 1993
Query: 393 PDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSP 452
V P +L I + D G Y CVA K G D I +++S P + Q
Sbjct: 1994 -HVYP-NGSLFIGSVTEKDSGVYLCVARNKMG---DDLILMHVSLRLKPAKIDHKQYFRK 2048
Query: 453 LVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSM 491
V G ++ C+ +G P P I WS +PDG+M
Sbjct: 2049 QVL-HGKDFQVDCKASGSPVPEISWS-------LPDGTM 2079
Score = 92.8 bits (229), Expect = 1e-18
Identities = 136/618 (22%), Positives = 234/618 (37%), Gaps = 60/618 (9%)
Query: 43 ERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF-----NETLRI 97
E S++ + G+ L L C TG P+PQI W + + D+ + N +L I
Sbjct: 1944 EAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFI 2003
Query: 98 TNIQRHQGGRYYCKAENGLGSPAIK---SIRVDVYYLDDPVVTVHQSIGEAKEQFYYERT 154
++ G Y C A N +G I S+R+ +D H+ ++Q + +
Sbjct: 2004 GSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKID------HKQY--FRKQVLHGKD 2055
Query: 155 VFLRCVANSNPPVRYSWRRGQEVLL----QGSDKGVEIYEPFFTQGETKILKLKNLRPQD 210
+ C A+ +P SW ++ Q D G +T L + +
Sbjct: 2056 FQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRR--YTLFNNGTLYFNKVGVAE 2113
Query: 211 YANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGE 270
+Y+C A +N + V L+ TA+P I+ + G+ L C TG +
Sbjct: 2114 EGDYTCYA--QNTLGKDEMKV--HLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTG-D 2168
Query: 271 PAPSLTWVRSFG-----TLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTN 325
P P + W+ ++ T G+LTI + D+G Y C+A N G+ K
Sbjct: 2169 PKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKL 2228
Query: 326 IIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSER 385
+V T K ++ ++ C+ E PS E+ + N
Sbjct: 2229 DVVSKPPLINGLYTNRTVIKATAVRHSKK-HFDCRAEGTPSPEVMWIMPDN--------- 2278
Query: 386 MVITQTDPDVSPGTT-----NLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTV 440
I T P T L+I +++ +D + CVA +GG S + + + +
Sbjct: 2279 --IFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGE-SVLVVQLEVLEMLR 2335
Query: 441 PPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILW--SRADKEVAMPDGSMQMESYDG 498
P P + +V + G + L C V G P P I+W + P + + +G
Sbjct: 2336 RPTFRNPFNEK-IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNG 2394
Query: 499 TLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVT 558
+ I +RE +G YRC G+ K ++ I Q P + A ++ S++
Sbjct: 2395 SFIISKTTREDAGKYRCAARNKVGYIEK---LVILEIGQKPVILTYAPGTVKGISGESLS 2451
Query: 559 MSCRVLRAYPIRVLTYEWRLGNKLLR---TGQFDSQEYTEYAVKSLSNENYGVYNCSIIN 615
+ C V P + + G + R G++ + +K + + G Y C N
Sbjct: 2452 LHC-VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQN 2510
Query: 616 EAGAGRCSFLVTGKAYAP 633
G + V AY P
Sbjct: 2511 SVGHTLITVPVMIVAYPP 2528
Score = 73.6 bits (179), Expect = 8e-13
Identities = 74/271 (27%), Positives = 109/271 (40%), Gaps = 37/271 (13%)
Query: 269 GEPAPSLTWVRSFGTLP--------EKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPA 320
G P P++ W R L VL GTL+I + D G Y C A+N G
Sbjct: 1674 GNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDH 1733
Query: 321 KKSTNIIV----RALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKN 376
T +V R L++ K+ + G V++ C+ E PS +T+
Sbjct: 1734 LHVTLSVVSYPPRILERRT---------KEITVHSGSTVELKCRAEGRPSPTVTWILANQ 1784
Query: 377 GRPLRSSE--RMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVN 434
SS+ R + D GT L + +L D G Y CVAS GG S+ V
Sbjct: 1785 TVVSESSQGSRQAVVTVD-----GT--LVLHNLSIYDRGFYKCVASNPGG---QDSLLVK 1834
Query: 435 ISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMP---DGSM 491
I PP + + Q + +V G++++L C G P+P + W +D P S
Sbjct: 1835 IQVIAAPP-VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSK 1893
Query: 492 QMESYDGTLRIVNVSREMSGMYRCQTSQYNG 522
+GTL I N++ G Y C + G
Sbjct: 1894 LFLFSNGTLYIRNLASSDRGTYECIATSSTG 1924
Score = 68.2 bits (165), Expect = 4e-11
Identities = 95/374 (25%), Positives = 145/374 (38%), Gaps = 43/374 (11%)
Query: 62 CLVTGHPRPQIRWTK------TAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENG 115
C G P P++ W TA R N TL I N++ + C A N
Sbjct: 2261 CRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHK--NGTLEIRNVRLSDSADFICVARNE 2318
Query: 116 LGSPAIKSIRVDVY-YLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRG 174
G ++ ++++V L P T E K ++ L C + NPP W
Sbjct: 2319 -GGESVLVVQLEVLEMLRRP--TFRNPFNE-KIVAQLGKSTALNCSVDGNPPPEIIW--- 2371
Query: 175 QEVLLQGS--DKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVS 232
+L G+ G + Y+ + I+ K R +D Y C A RN +K+V
Sbjct: 2372 --ILPNGTRFSNGPQSYQYLIASNGSFIIS-KTTR-EDAGKYRCAA--RNKVGYIEKLVI 2425
Query: 233 FRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNG 292
+ K P I + GE+++L CV+ G P P++ W G + ++ +NG
Sbjct: 2426 LEIGQK---PVILTYAPGTVKGISGESLSLHCVSDG-IPKPNIKWTMPSGYVVDRPQING 2481
Query: 293 -------GTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHK 345
GTL I T+ D G Y C A N+VG+ +IV + IT P +
Sbjct: 2482 KYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPR----ITNRP-PR 2536
Query: 346 DDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDII 405
+ G ++ C VP E+T W L S+ T + T L I
Sbjct: 2537 SIVTRTGAAFQLHCVALGVPKPEIT--WEMPDHSLLSTASKERTHGSEQLHLQGT-LVIQ 2593
Query: 406 DLKFTDFGTYTCVA 419
+ + +D G Y C A
Sbjct: 2594 NPQTSDSGIYKCTA 2607
Score = 58.9 bits (141), Expect = 2e-08
Identities = 68/276 (24%), Positives = 123/276 (44%), Gaps = 23/276 (8%)
Query: 362 EAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASL 421
EAV + T W + L S+R ++ V P T L I ++ D G Y C AS
Sbjct: 1671 EAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQ--VLPNGT-LSIQRVEIQDRGQYLCSASN 1727
Query: 422 KGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRAD 481
G + V +S + PP + + K + G T+EL+C+ G+P P + W A+
Sbjct: 1728 LFG---TDHLHVTLSVVSYPPRILERRTKE-ITVHSGSTVELKCRAEGRPSPTVTWILAN 1783
Query: 482 KEVA--MPDGSMQ-MESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQL-IVQ 537
+ V GS Q + + DGTL + N+S G Y+C S G + LV++ ++
Sbjct: 1784 QTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQD----SLLVKIQVIA 1839
Query: 538 YPPAVEPAFLEIRQGQ-DRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEY 596
PP + ++ G S+ + C + P + + G + ++ QF + + +
Sbjct: 1840 APPVILEQRRQVIVGTWGESLKLPC-TAKGTPQPSVYWVLSDGTE-VKPLQFTNSKLFLF 1897
Query: 597 A-----VKSLSNENYGVYNCSIINEAGAGRCSFLVT 627
+ +++L++ + G Y C + G+ R ++T
Sbjct: 1898 SNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLT 1933
Score = 55.8 bits (133), Expect = 2e-07
Identities = 69/284 (24%), Positives = 101/284 (35%), Gaps = 42/284 (14%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAGS----ASDRFQDSSVFNETLRITNIQRHQGGRYYC 110
G++ L C V G+P P+I W G+ +Q N + I+ R G+Y C
Sbjct: 2352 GKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRC 2411
Query: 111 KAENGLG---SPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPV 167
A N +G I I L TV GE+ + L CV++ P
Sbjct: 2412 AARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGES---------LSLHCVSDGIPKP 2462
Query: 168 RYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASV---RNVC 224
W ++ + + + L +K D NY C A +
Sbjct: 2463 NIKWTMPSGYVVDRPQINGK-----YILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLI 2517
Query: 225 NIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWV---RSF 281
+P +V++ P I IV G A L CV G P P +TW S
Sbjct: 2518 TVPVMIVAY-------PPRITNRPPRSIVTRTGAAFQLHCVALG-VPKPEITWEMPDHSL 2569
Query: 282 GTLPEKTVLNG-------GTLTIPAITSDDAGTYSCIANNNVGN 318
+ K +G GTL I + D+G Y C A N +G+
Sbjct: 2570 LSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGS 2613
Score = 47.4 bits (111), Expect = 7e-05
Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 29/177 (16%)
Query: 154 TVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQ-GETKILKLKNLRPQ--- 209
TV L C +P W +L GS ++ P+ ++ G I K L Q
Sbjct: 492 TVGLNCPGQGDPTPHVDW-----LLADGS----KVRAPYVSEDGRILIDKSGKLELQMAD 542
Query: 210 --DYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPI--VVNPGEAITLVCV 265
D Y CI+S + +I +++R++ P ++ ++ I V GE + L C
Sbjct: 543 SFDTGVYHCISSNYDDADI----LTYRIT--VVEPLVEAYQENGIHHTVFIGETLDLPCH 596
Query: 266 TTGGEPAPSLTWVRS-----FGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVG 317
+TG P S++WV + + +K VLN GTL I +T D G Y C+A N G
Sbjct: 597 STG-IPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
Score = 42.0 bits (97), Expect = 0.003
Identities = 50/188 (26%), Positives = 76/188 (40%), Gaps = 22/188 (11%)
Query: 40 IEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGS---ASDRFQDSSVF---NE 93
I + ++ +T+ G T+ L C G P P + W GS A +D + +
Sbjct: 475 ISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSG 534
Query: 94 TLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYER 153
L + G Y+C + N I + R+ V +P+V +Q G F E
Sbjct: 535 KLELQMADSFDTGVYHCISSN-YDDADILTYRITVV---EPLVEAYQENGIHHTVFIGE- 589
Query: 154 TVFLRCVANSNPPVRYSW-RRGQEVLLQGS-DKGVEIYEPFFTQGETKILKLKNLRPQDY 211
T+ L C + P SW G VL Q S DK V G +IL+ + P+D
Sbjct: 590 TLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKV------LNNGTLRILQ---VTPKDQ 640
Query: 212 ANYSCIAS 219
Y C+A+
Sbjct: 641 GYYRCVAA 648
Score = 41.6 bits (96), Expect = 0.004
Identities = 36/130 (27%), Positives = 55/130 (42%), Gaps = 6/130 (4%)
Query: 411 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTRE-GDTIELQCQVTG 469
D G Y C++S D I + + V P + QE T G+T++L C TG
Sbjct: 545 DTGVYHCISS----NYDDADI-LTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTG 599
Query: 470 KPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPRE 529
P I W V + +GTLRI+ V+ + G YRC + +G + +
Sbjct: 600 IPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQ 659
Query: 530 ALVQLIVQYP 539
V++ Q P
Sbjct: 660 VSVKMKGQRP 669
Score = 39.7 bits (91), Expect = 0.014
Identities = 25/78 (32%), Positives = 31/78 (39%), Gaps = 7/78 (8%)
Query: 48 RVYTIREGETLELTCLVTGHPRPQIRW-------TKTAGSASDRFQDSSVFNETLRITNI 100
R R G +L C+ G P+P+I W TA + TL I N
Sbjct: 2536 RSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNP 2595
Query: 101 QRHQGGRYYCKAENGLGS 118
Q G Y C A+N LGS
Sbjct: 2596 QTSDSGIYKCTAKNPLGS 2613
Score = 37.4 bits (85), Expect = 0.067
Identities = 25/70 (35%), Positives = 31/70 (44%), Gaps = 2/70 (2%)
Query: 50 YTIREGETLELTCLVTGHPRPQIRWTKTAGSA-SDRFQDSSVFNE-TLRITNIQRHQGGR 107
+T+ GETL+L C TG P I W + +D V N TLRI + G
Sbjct: 583 HTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGY 642
Query: 108 YYCKAENGLG 117
Y C A N G
Sbjct: 643 YRCVAANPSG 652
Score = 32.0 bits (71), Expect = 2.8
Identities = 45/183 (24%), Positives = 74/183 (40%), Gaps = 20/183 (10%)
Query: 458 GDTIELQCQVTGKPKPIILWSRAD-KEVAMP----DGSMQMESYDGTLRIVNVSREMSGM 512
G T+ L C G P P + W AD +V P DG + ++ G L + +G+
Sbjct: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDK-SGKLELQMADSFDTGV 548
Query: 513 YRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRV---LRAYPI 569
Y C +S Y+ ++ L I P VE A+ E G +V + + + I
Sbjct: 549 YHCISSNYDDADI-----LTYRITVVEPLVE-AYQE--NGIHHTVFIGETLDLPCHSTGI 600
Query: 570 RVLTYEWRL-GNKLLRTGQFDSQEYTEYAVKSL--SNENYGVYNCSIINEAGAGRCSFLV 626
+ W + GN +L D + ++ L + ++ G Y C N +G F V
Sbjct: 601 PDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQV 660
Query: 627 TGK 629
+ K
Sbjct: 661 SVK 663
>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
Length = 1018
Score = 107 bits (266), Expect = 7e-23
Identities = 173/788 (21%), Positives = 277/788 (35%), Gaps = 129/788 (16%)
Query: 49 VYTIREGETLE----LTCLVTGHPRPQIRWTKTAGSA---SDRFQDSSVFNETLRITNIQ 101
+ TI E+LE L C P P +W G SDR+ S+ L I N
Sbjct: 48 INTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRY---SMVGGNLVINNPD 104
Query: 102 RHQ-GGRYYCKAENGLGSPAIKSIRVDVYYLDD------PVVTVHQSIGEAKEQFYYERT 154
+ + G YYC A N G + YLD P V V + G
Sbjct: 105 KQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKG----------- 153
Query: 155 VFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANY 214
+ L C +PP + LL + + + F L + N+ D NY
Sbjct: 154 MVLLC----DPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNY 209
Query: 215 SCIASVRNVC-NIPDKMVSF-RLSNKTASPSIKLLVDD--PIVVNPGEAITLVCVTTGGE 270
SC S ++ ++ K + + +T P +V + G+ +TL C G
Sbjct: 210 SCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGN- 268
Query: 271 PAPSLTWVRSFGTLPEKTVLN--GGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIV 328
P P + W + +P ++ G L I I +D G Y C A N G K I V
Sbjct: 269 PVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKD-KHQARIYV 327
Query: 329 RALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVI 388
+A + W+ + D + IG ++ C P T W KNG E
Sbjct: 328 QAFPE---WVE---HINDTEVDIGSDLYWPCVATGKPIP--TIRWLKNGYAYHKGE---- 375
Query: 389 TQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQ 448
L + D+ F + G Y C+A G I + + + P +
Sbjct: 376 -------------LRLYDVTFENAGMYQCIAENTYGAIY---ANAELKILALAPTFEMNP 419
Query: 449 EKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSRE 508
K ++ +G + ++C+ PKP WS+ + + + E DG+L I N++R
Sbjct: 420 MKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWE--DGSLEINNITRN 477
Query: 509 MSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV--EPAFLEIRQGQDRSVTMSCRVLRA 566
G+Y C G + L++ P + P +I G+ + TM C
Sbjct: 478 DGGIYTCFAENNRG----KANSTGTLVITDPTRIILAPINADITVGE--NATMQC-AASF 530
Query: 567 YPIRVLTYEWRLGNKLL----------RTGQFDSQEYTEYAVKSLSNENYGVYNCS--II 614
P LT+ W ++ R DS E +++ ++ G Y C+ I
Sbjct: 531 DPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSN--GELLIRNAQLKHAGRYTCTAQTI 588
Query: 615 NEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLG 674
+ + +V G P + R S +L W++ D I Y +
Sbjct: 589 VDNSSASADLVVRGPPGPP-------GGLRIEDIRATSVALTWSR-GSDNHSPISKYTIQ 640
Query: 675 IRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTI---R 731
+ W ++ K + I +G + +LI YE R+ G G+ +I R
Sbjct: 641 TKTILSDDW--KDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNR 698
Query: 732 VIKYSAPVN---------------------PHLREFHCGFEDGNICLFTQDDTDNFDWTK 770
+ A N P RE+H G G I F D + +W K
Sbjct: 699 IKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGE--EWKK 756
Query: 771 QSTATRNT 778
+ +T
Sbjct: 757 VTVTNPDT 764
>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
Length = 1007
Score = 107 bits (266), Expect = 7e-23
Identities = 173/788 (21%), Positives = 277/788 (35%), Gaps = 129/788 (16%)
Query: 49 VYTIREGETLE----LTCLVTGHPRPQIRWTKTAGSA---SDRFQDSSVFNETLRITNIQ 101
+ TI E+LE L C P P +W G SDR+ S+ L I N
Sbjct: 37 INTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRY---SMVGGNLVINNPD 93
Query: 102 RHQ-GGRYYCKAENGLGSPAIKSIRVDVYYLDD------PVVTVHQSIGEAKEQFYYERT 154
+ + G YYC A N G + YLD P V V + G
Sbjct: 94 KQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKG----------- 142
Query: 155 VFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANY 214
+ L C +PP + LL + + + F L + N+ D NY
Sbjct: 143 MVLLC----DPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNY 198
Query: 215 SCIASVRNVC-NIPDKMVSF-RLSNKTASPSIKLLVDD--PIVVNPGEAITLVCVTTGGE 270
SC S ++ ++ K + + +T P +V + G+ +TL C G
Sbjct: 199 SCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGN- 257
Query: 271 PAPSLTWVRSFGTLPEKTVLN--GGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIV 328
P P + W + +P ++ G L I I +D G Y C A N G K I V
Sbjct: 258 PVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKD-KHQARIYV 316
Query: 329 RALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVI 388
+A + W+ + D + IG ++ C P T W KNG E
Sbjct: 317 QAFPE---WVE---HINDTEVDIGSDLYWPCVATGKPIP--TIRWLKNGYAYHKGE---- 364
Query: 389 TQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQ 448
L + D+ F + G Y C+A G I + + + P +
Sbjct: 365 -------------LRLYDVTFENAGMYQCIAENTYGAIY---ANAELKILALAPTFEMNP 408
Query: 449 EKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSRE 508
K ++ +G + ++C+ PKP WS+ + + + E DG+L I N++R
Sbjct: 409 MKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWE--DGSLEINNITRN 466
Query: 509 MSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV--EPAFLEIRQGQDRSVTMSCRVLRA 566
G+Y C G + L++ P + P +I G+ + TM C
Sbjct: 467 DGGIYTCFAENNRG----KANSTGTLVITDPTRIILAPINADITVGE--NATMQC-AASF 519
Query: 567 YPIRVLTYEWRLGNKLL----------RTGQFDSQEYTEYAVKSLSNENYGVYNCS--II 614
P LT+ W ++ R DS E +++ ++ G Y C+ I
Sbjct: 520 DPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSN--GELLIRNAQLKHAGRYTCTAQTI 577
Query: 615 NEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLG 674
+ + +V G P + R S +L W++ D I Y +
Sbjct: 578 VDNSSASADLVVRGPPGPP-------GGLRIEDIRATSVALTWSR-GSDNHSPISKYTIQ 629
Query: 675 IRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTI---R 731
+ W ++ K + I +G + +LI YE R+ G G+ +I R
Sbjct: 630 TKTILSDDW--KDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNR 687
Query: 732 VIKYSAPVN---------------------PHLREFHCGFEDGNICLFTQDDTDNFDWTK 770
+ A N P RE+H G G I F D + +W K
Sbjct: 688 IKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGE--EWKK 745
Query: 771 QSTATRNT 778
+ +T
Sbjct: 746 VTVTNPDT 753
>gi|223278413 MAM domain containing 2 [Homo sapiens]
Length = 686
Score = 105 bits (263), Expect = 2e-22
Identities = 68/182 (37%), Positives = 92/182 (50%), Gaps = 16/182 (8%)
Query: 748 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPR 807
C FE C FTQ+ + W ++ R T TGP D + + G+YMYIE S
Sbjct: 509 CTFEQDE-CTFTQEKRNRSSWHRR----RGETPTSYTGPKGDHT-TGVGYYMYIEASH-M 561
Query: 808 LEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPL 867
+ G+KARLLS P + +C +FFYHMYG G+L+VYL+ K + + E+ L
Sbjct: 562 VYGQKARLLS--------RPLRGVSGKHCLTFFYHMYGGGTGLLSVYLK-KEEDSEESLL 612
Query: 868 WSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATK 927
W G + W A + Q+IFE IRG I DIAIDDV G C + + T+
Sbjct: 613 WRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPCGEMEDTTQ 672
Query: 928 NS 929
S
Sbjct: 673 QS 674
Score = 58.9 bits (141), Expect = 2e-08
Identities = 48/179 (26%), Positives = 79/179 (44%), Gaps = 22/179 (12%)
Query: 748 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPR 807
C FE+ ++C F N +W + RN + P S+ G YMY+++ +
Sbjct: 170 CDFEENHLCGFVNRWNPNVNWFVGGGSIRNVH---SILPQDHTFKSELGHYMYVDSVYVK 226
Query: 808 LEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPL 867
E A+L+SP+ + AP A C SF+Y + + V ++Y R + +
Sbjct: 227 HFQEVAQLISPL-TTAP--------MAGCLSFYYQIQQGNDNVFSLYTR--DVAGLYEEI 275
Query: 868 WSSSGNKGQRWNEAHVNI---YPI-TSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQ 922
W + WN A V YP+ F++ F G +G G +A+DD+S + C Q
Sbjct: 276 WKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKG----GYVALDDISFSPVHCQNQ 330
Score = 45.1 bits (105), Expect = 3e-04
Identities = 44/182 (24%), Positives = 72/182 (39%), Gaps = 23/182 (12%)
Query: 745 EFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETS 804
E C FE ++C F QD + WT+ K PN D + G+Y+ T
Sbjct: 339 EASCNFEQ-DLCNFYQDK-EGPGWTR-------VKVKPNMYRAGDHTTGL-GYYLLANTK 388
Query: 805 RPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYG--QHIGVLNVYLRLKGQTT 862
G RL P P N YC F Y +YG + L VY+ +
Sbjct: 389 FTSQPGYIGRLYGPSL---------PGNLQYCLRFHYAIYGFLKMSDTLAVYI-FEENHV 438
Query: 863 IENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIE-GDIAIDDVSIAEGECAK 921
++ +WS + W +A + +++F + + G +A+DD++I G C+
Sbjct: 439 VQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLGSCSS 498
Query: 922 QD 923
+
Sbjct: 499 SE 500
Score = 44.3 bits (103), Expect = 6e-04
Identities = 35/137 (25%), Positives = 65/137 (47%), Gaps = 18/137 (13%)
Query: 793 SKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGV-- 850
++EG Y+Y++TS + +GEKA LLSP + C Y + +
Sbjct: 47 NEEGHYIYVDTSFGK-QGEKAVLLSPDLQAEEWS---------CLRLVYQITTSSESLSD 96
Query: 851 ---LNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITS-FQLIFEGIRGPGIEGD 906
LN+Y+R + ++ + LWS+ W A +++ + F+++ EG+ G G
Sbjct: 97 PSQLNLYMRFEDES-FDRLLWSAK-EPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTAS 154
Query: 907 IAIDDVSIAEGECAKQD 923
IA+ ++ + G C + D
Sbjct: 155 IALFEIKMTTGYCIECD 171
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 105 bits (261), Expect = 3e-22
Identities = 169/722 (23%), Positives = 269/722 (37%), Gaps = 100/722 (13%)
Query: 60 LTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFN---ETLRITNIQRHQG-GRYYCKAENG 115
L C G+P P RW K G+ D F S + +L I + Q G Y C A N
Sbjct: 48 LNCAANGYPSPHYRW-KQNGTDID-FTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATNL 105
Query: 116 LGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPP-----VRYS 170
LG+ + ++ Y++D ++ + Q V L C PP + Y+
Sbjct: 106 LGTILSRKAKLQFAYIEDFETKTRSTVSVREGQ-----GVVLLC----GPPPHFGDLSYA 156
Query: 171 WRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIAS----VRNVCNI 226
W L D F ET L + + P D NY+C + R+V
Sbjct: 157 WTFNDNPLYVQEDNRR------FVSQETGNLYIAKVEPSDVGNYTCFITNKEAQRSVQGP 210
Query: 227 PDKMVSFRLSNKTAS--PSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGT- 283
P +V R P I++ + I ++ L C G P P ++W R G+
Sbjct: 211 PTPLVQ-RTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGN-PVPDISWRRLDGSP 268
Query: 284 LPEKTVLNGGT--LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGR--FWIT 339
LP K + L IP +D G Y CIA+N G R L KG+ F+
Sbjct: 269 LPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRG-----------RNLAKGQLIFYAP 317
Query: 340 PDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGT 399
P+ K N + + + +A ++W KNG L ER+ I GT
Sbjct: 318 PEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEERIQIEN-------GT 370
Query: 400 TNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGD 459
L I L +D G Y C A K I + + P+ + K + G
Sbjct: 371 --LIITMLNVSDSGVYQCAAENK---YQIIYANAELRVLASAPDFSKSPVKKKSFVQVGG 425
Query: 460 TIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQ 519
I + C+ P+ I W R + + +E DG+L+I N++R +G Y C +
Sbjct: 426 DIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLE--DGSLKIYNITRSDAGSYTCIAT- 482
Query: 520 YNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLG 579
N F + + + V P+ +++ G+ S+ + C+V I V+ + W
Sbjct: 483 -NQFGTAKNTGSLIVKERTVITVPPSKMDVTVGE--SIVLPCQVSHDPSIEVV-FVWFFN 538
Query: 580 NKL--LRTG-----QFDSQEYTEYAVKSLSNENYGVYNCSIIN--EAGAGRCSFLVTGKA 630
+ L+ G + + + ++++ + G Y C++ E+ + +V G
Sbjct: 539 GDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPP 598
Query: 631 YAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKI 690
PE V + L W + PD I + + R W Q +
Sbjct: 599 GPPE-------DVQVEDISSTTSQLSW-RAGPDNNSPIQIFTIQTRTPFSVGW--QAVAT 648
Query: 691 NGNIQKGELITYNLTEL-IKP-EAYEVRLTPLTKFGEGD--------STIRVIKYSAPVN 740
I G+ TYN T + + P YE R+ G G+ T + APVN
Sbjct: 649 VPEILNGK--TYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVN 706
Query: 741 PH 742
H
Sbjct: 707 IH 708
Score = 92.0 bits (227), Expect = 2e-18
Identities = 113/433 (26%), Positives = 174/433 (40%), Gaps = 47/433 (10%)
Query: 21 QGVYAPPTVRIVHS-GLACNIE---EERYSERVYTIREGETLELTCLVTGHPRPQIRWTK 76
+ V PPT + + G+ E E R+ E + ++ +++L C G+P P I W +
Sbjct: 205 RSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDS-SVKLECFALGNPVPDISWRR 263
Query: 77 TAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYL----D 132
GS S L I N Q+ G Y C A N G K + +Y +
Sbjct: 264 LDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLI--FYAPPEWE 321
Query: 133 DPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPF 192
+ H SI Y+ ++ C A+ P Y+W + E L ++ ++I
Sbjct: 322 QKIQNTHLSI--------YDNLLW-ECKASGKPNPWYTWLKNGERL--NPEERIQI---- 366
Query: 193 FTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPI 252
E L + L D Y C A N I R+ +A K V
Sbjct: 367 ----ENGTLIITMLNVSDSGVYQCAAE--NKYQIIYANAELRVL-ASAPDFSKSPVKKKS 419
Query: 253 VVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT---VLNGGTLTIPAITSDDAGTYS 309
V G I + C P +++W R TL + +L G+L I IT DAG+Y+
Sbjct: 420 FVQVGGDIVIGC-KPNAFPRAAISWKRGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYT 478
Query: 310 CIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEEL 369
CIA N G AK + ++IV K R IT P D + +G + + CQV PS E+
Sbjct: 479 CIATNQFGT-AKNTGSLIV----KERTVITVPPSKMD--VTVGESIVLPCQVSHDPSIEV 531
Query: 370 TFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDI 429
F WF NG + + + + S G +L I +++ G Y C +S +
Sbjct: 532 VFVWFFNGDVIDLKKGVAHFERIGGESVG--DLMIRNIQLHHSGKYLCTVQTTLESLSAV 589
Query: 430 SIDVNISSSTVPP 442
+ D+ + PP
Sbjct: 590 A-DIIVRGPPGPP 601
Score = 59.7 bits (143), Expect = 1e-08
Identities = 99/488 (20%), Positives = 191/488 (39%), Gaps = 65/488 (13%)
Query: 155 VFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANY 214
V L C AN P Y W++ G+D + + G + + + QD Y
Sbjct: 46 VILNCAANGYPSPHYRWKQ------NGTDIDFTMSYHYRLDGGSLAINSPH-TDQDIGMY 98
Query: 215 SCIASVRNVCNIPDKMVSFRLSNKTA-SPSIKLLVDDPIVVNPGEAITLVCVTTGGEPA- 272
C+A+ N+ ++S + + A + + V G+ + L+C G P
Sbjct: 99 QCLAT-----NLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLC----GPPPH 149
Query: 273 -PSLTWVRSFGTLP--------EKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKS 323
L++ +F P G L I + D G Y+C N + +
Sbjct: 150 FGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQRSVQG 209
Query: 324 --TNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFK-NGRPL 380
T ++ R + + IQ ++ + + A+ + SW + +G PL
Sbjct: 210 PPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPL 269
Query: 381 RSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVAS-LKGGGISDISIDVNISSST 439
+ S L+I + + D G Y C+AS L+G ++ +
Sbjct: 270 PGKVK---------YSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQL-----IFY 315
Query: 440 VPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT 499
PP + + L D + +C+ +GKP P W + + E P+ +Q+E +GT
Sbjct: 316 APPEWEQKIQNTHLSIY--DNLLWECKASGKPNPWYTWLK-NGERLNPEERIQIE--NGT 370
Query: 500 LRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYP-----PAVEPAFLEIRQGQD 554
L I ++ SG+Y+C N + + A ++++ P P + +F+++ G D
Sbjct: 371 LIITMLNVSDSGVYQCAAE--NKYQIIYANAELRVLASAPDFSKSPVKKKSFVQV--GGD 426
Query: 555 RSVTMSCRVLRAYPIRVLTYEWRLGNKLLR-TGQFDSQEYTEYAVKSLSNENYGVYNCSI 613
+ + C+ A+P ++ W+ G + LR + + E + +++ + G Y C
Sbjct: 427 --IVIGCKP-NAFPRAAIS--WKRGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIA 481
Query: 614 INEAGAGR 621
N+ G +
Sbjct: 482 TNQFGTAK 489
>gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]
Length = 613
Score = 100 bits (249), Expect = 6e-21
Identities = 104/378 (27%), Positives = 157/378 (41%), Gaps = 49/378 (12%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCK 111
+ G L L C+ +G P P I W K G FN+ LRITN+ G Y+C
Sbjct: 252 VLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCL 311
Query: 112 AENGLGS-PAIKSIRVDV--YYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
A N +GS S+RV Y+LD+P + + + L C AN NP
Sbjct: 312 ASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGR----------LVCRANGNPKPT 361
Query: 169 YSWR-RGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIP 227
W G+ + + E+ G+T I ++ + A Y C S + +
Sbjct: 362 VQWMVNGEPLQSAPPNPNREV------AGDTII--FRDTQISSRAVYQCNTSNEHGYLLA 413
Query: 228 DKMVS-FRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVR----SFG 282
+ VS + + SP +L+ I+ N T + G P P+L W + S
Sbjct: 414 NAFVSVLDVPPRMLSPRNQLI--RVILYNR----TRLDCPFFGSPIPTLRWFKNGQGSNL 467
Query: 283 TLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDP 342
V G+L I I +D G Y+C+A N +G K + + R + P+
Sbjct: 468 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILG---KAENQVRLEVKDPTRIYRMPE- 523
Query: 343 YHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNL 402
D + G V++ C+V+ PS +LT SW K+ PL RM + + D +L
Sbjct: 524 ---DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRM---KKEDD------SL 571
Query: 403 DIIDLKFTDFGTYTCVAS 420
I + D G+YTCVAS
Sbjct: 572 TIFGVAERDQGSYTCVAS 589
Score = 87.8 bits (216), Expect = 4e-17
Identities = 104/476 (21%), Positives = 176/476 (36%), Gaps = 38/476 (7%)
Query: 155 VFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDY-AN 213
+ + C A NP + W R D V + G I RP++Y
Sbjct: 53 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRR---RSGTLVIDFRSGGRPEEYEGE 109
Query: 214 YSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAP 273
Y C A + + ++ + ++S P L DP+VV G +TL C G P+P
Sbjct: 110 YQCFARNKFGTALSNR-IRLQVSKSPLWPKENL---DPVVVQEGAPLTLQCNPPPGLPSP 165
Query: 274 SLTWVRSF--GTLPEKTVLNG--GTLTIPAITSDDAGT-YSCIANNNVGNPAKKSTNIIV 328
+ W+ S +K V G G L + D T YSC A + + ++ +
Sbjct: 166 VIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTL 225
Query: 329 RAL------KKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRS 382
+ L ++ ++ P + G ++ + C VP+ ++ +W+K G L S
Sbjct: 226 KVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI--AWYKKGGDLPS 283
Query: 383 SERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPP 442
+ L I ++ D G Y C+AS K G I +++ P
Sbjct: 284 DK--------AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRH---TISVRVKAAPY 332
Query: 443 NLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRI 502
L P+ L+ G+ L C+ G PKP + W + + + E T+
Sbjct: 333 WLDEPKN---LILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 389
Query: 503 VNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCR 562
+ +Y+C TS +G+ + A V ++ P + P IR + C
Sbjct: 390 RDTQISSRAVYQCNTSNEHGYLL--ANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCP 447
Query: 563 VLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAG 618
+ PI L + L G + E +K + E+ G+Y C N G
Sbjct: 448 FFGS-PIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILG 502
Score = 68.6 bits (166), Expect = 3e-11
Identities = 88/376 (23%), Positives = 156/376 (41%), Gaps = 56/376 (14%)
Query: 155 VFLRCVANSNPPVRYSW-RRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYAN 213
+ L C+A+ P +W ++G ++ SDK +E F K L++ N+ +D
Sbjct: 258 LLLECIASGVPTPDIAWYKKGGDL---PSDKAK--FENF-----NKALRITNVSEEDSGE 307
Query: 214 YSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDP--IVVNPGEAITLVCVTTGGEP 271
Y C+AS +KM S R + + +D+P +++ PGE LVC G P
Sbjct: 308 YFCLAS--------NKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVC-RANGNP 358
Query: 272 APSLTWV------RSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTN 325
P++ W+ +S P + V G T+ Y C +N G N
Sbjct: 359 KPTVQWMVNGEPLQSAPPNPNREVA-GDTIIFRDTQISSRAVYQCNTSNEHGYLL---AN 414
Query: 326 IIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSER 385
V L ++P ++ + + ++ C P T WFKNG+
Sbjct: 415 AFVSVLDVPPRMLSPR--NQLIRVILYNRTRLDCPFFGSPIP--TLRWFKNGQGSNLDGG 470
Query: 386 MVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVAS-LKGGGISDISIDVNISSSTVPPNL 444
+ +L+I ++ D G YTCVA+ + G + + ++V +
Sbjct: 471 NYHVYENG-------SLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIY---- 519
Query: 445 TVPQEKSPLVTREGDTIELQCQVTGKP--KPIILWSRADKEVAMPDGSMQMESYDGTLRI 502
+P+++ V R G T++L+C+V P K + W + D+ + + + +M+ D +L I
Sbjct: 520 RMPEDQ---VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGN---RMKKEDDSLTI 573
Query: 503 VNVSREMSGMYRCQTS 518
V+ G Y C S
Sbjct: 574 FGVAERDQGSYTCVAS 589
Score = 57.0 bits (136), Expect = 8e-08
Identities = 102/428 (23%), Positives = 157/428 (36%), Gaps = 60/428 (14%)
Query: 216 CIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSL 275
C+ S+ IP + T P+I +V+P + I + C G PAPS
Sbjct: 17 CLLSLGGAIEIPMDL--------TQPPTITKQSAKDHIVDPRDNILIECEAKGN-PAPSF 67
Query: 276 TWVRS---FGTLPEKTVL---NGGTLTIPAITS----DDAGTYSCIANNNVGNPAKKSTN 325
W R+ F + V GTL I + + G Y C A N G +N
Sbjct: 68 HWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTAL---SN 124
Query: 326 IIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPS-EELTFSWFKNGRPLRSSE 384
I + K W P D + + ++ Q P W SS
Sbjct: 125 RIRLQVSKSPLW----PKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM-------SSS 173
Query: 385 RMVITQTDPDVSPGTT-NLDIIDLKFTDFGT-YTCVA------SLKGGGISDISIDVNIS 436
ITQ D VS G +L ++ D T Y+C A +++ + +
Sbjct: 174 MEPITQ-DKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 232
Query: 437 SSTVPPNLTVPQ--EKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQME 494
+ P+ PQ S +V R D + L+C +G P P I W + + +P + E
Sbjct: 233 VAERTPSFMYPQGTASSQMVLRGMDLL-LECIASGVPTPDIAWYKKGGD--LPSDKAKFE 289
Query: 495 SYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV-EPAFLEIRQGQ 553
+++ LRI NVS E SG Y C S G R + + P + EP L + G+
Sbjct: 290 NFNKALRITNVSEEDSGEYFCLASNKMG---SIRHTISVRVKAAPYWLDEPKNLILAPGE 346
Query: 554 DRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYT---EYAVKSLSNENYGVYN 610
D + V RA T +W + + L++ + + + VY
Sbjct: 347 DGRL-----VCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQ 401
Query: 611 CSIINEAG 618
C+ NE G
Sbjct: 402 CNTSNEHG 409
Score = 44.3 bits (103), Expect = 6e-04
Identities = 62/276 (22%), Positives = 105/276 (38%), Gaps = 28/276 (10%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAG--SASDRFQDSSVFNETLRITNIQRHQGGRYYCKA 112
GE L C G+P+P ++W ++ + V +T+ + Q Y C
Sbjct: 345 GEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNT 404
Query: 113 ENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSW- 171
N G + V LD P + + Y RT L C +P W
Sbjct: 405 SNEHGYLLANAF---VSVLDVPPRMLSPR-NQLIRVILYNRTR-LDCPFFGSPIPTLRWF 459
Query: 172 RRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMV 231
+ GQ L G + V E L++K +R +D Y+C+A+ N+ + V
Sbjct: 460 KNGQGSNLDGGNYHVY---------ENGSLEIKMIRKEDQGIYTCVAT--NILGKAENQV 508
Query: 232 SFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLT--WVRSFGTL--PEK 287
+ + T I + +D V G + L C +P+ LT W++ L +
Sbjct: 509 RLEVKDPTR---IYRMPEDQ-VARRGTTVQLEC-RVKHDPSLKLTVSWLKDDEPLYIGNR 563
Query: 288 TVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKS 323
+LTI + D G+Y+C+A+ + K+
Sbjct: 564 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKA 599
>gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
Length = 619
Score = 100 bits (249), Expect = 6e-21
Identities = 104/378 (27%), Positives = 157/378 (41%), Gaps = 49/378 (12%)
Query: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCK 111
+ G L L C+ +G P P I W K G FN+ LRITN+ G Y+C
Sbjct: 258 VLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCL 317
Query: 112 AENGLGS-PAIKSIRVDV--YYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVR 168
A N +GS S+RV Y+LD+P + + + L C AN NP
Sbjct: 318 ASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGR----------LVCRANGNPKPT 367
Query: 169 YSWR-RGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIP 227
W G+ + + E+ G+T I ++ + A Y C S + +
Sbjct: 368 VQWMVNGEPLQSAPPNPNREV------AGDTII--FRDTQISSRAVYQCNTSNEHGYLLA 419
Query: 228 DKMVS-FRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVR----SFG 282
+ VS + + SP +L+ I+ N T + G P P+L W + S
Sbjct: 420 NAFVSVLDVPPRMLSPRNQLI--RVILYNR----TRLDCPFFGSPIPTLRWFKNGQGSNL 473
Query: 283 TLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDP 342
V G+L I I +D G Y+C+A N +G K + + R + P+
Sbjct: 474 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILG---KAENQVRLEVKDPTRIYRMPE- 529
Query: 343 YHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNL 402
D + G V++ C+V+ PS +LT SW K+ PL RM + + D +L
Sbjct: 530 ---DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRM---KKEDD------SL 577
Query: 403 DIIDLKFTDFGTYTCVAS 420
I + D G+YTCVAS
Sbjct: 578 TIFGVAERDQGSYTCVAS 595
Score = 87.8 bits (216), Expect = 4e-17
Identities = 104/476 (21%), Positives = 176/476 (36%), Gaps = 38/476 (7%)
Query: 155 VFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDY-AN 213
+ + C A NP + W R D V + G I RP++Y
Sbjct: 59 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRR---RSGTLVIDFRSGGRPEEYEGE 115
Query: 214 YSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAP 273
Y C A + + ++ + ++S P L DP+VV G +TL C G P+P
Sbjct: 116 YQCFARNKFGTALSNR-IRLQVSKSPLWPKENL---DPVVVQEGAPLTLQCNPPPGLPSP 171
Query: 274 SLTWVRSF--GTLPEKTVLNG--GTLTIPAITSDDAGT-YSCIANNNVGNPAKKSTNIIV 328
+ W+ S +K V G G L + D T YSC A + + ++ +
Sbjct: 172 VIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTL 231
Query: 329 RAL------KKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRS 382
+ L ++ ++ P + G ++ + C VP+ ++ +W+K G L S
Sbjct: 232 KVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI--AWYKKGGDLPS 289
Query: 383 SERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPP 442
+ L I ++ D G Y C+AS K G I +++ P
Sbjct: 290 DK--------AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRH---TISVRVKAAPY 338
Query: 443 NLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRI 502
L P+ L+ G+ L C+ G PKP + W + + + E T+
Sbjct: 339 WLDEPKN---LILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 395
Query: 503 VNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCR 562
+ +Y+C TS +G+ + A V ++ P + P IR + C
Sbjct: 396 RDTQISSRAVYQCNTSNEHGYLL--ANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCP 453
Query: 563 VLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAG 618
+ PI L + L G + E +K + E+ G+Y C N G
Sbjct: 454 FFGS-PIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILG 508
Score = 68.6 bits (166), Expect = 3e-11
Identities = 88/376 (23%), Positives = 156/376 (41%), Gaps = 56/376 (14%)
Query: 155 VFLRCVANSNPPVRYSW-RRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYAN 213
+ L C+A+ P +W ++G ++ SDK +E F K L++ N+ +D
Sbjct: 264 LLLECIASGVPTPDIAWYKKGGDL---PSDKAK--FENF-----NKALRITNVSEEDSGE 313
Query: 214 YSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDP--IVVNPGEAITLVCVTTGGEP 271
Y C+AS +KM S R + + +D+P +++ PGE LVC G P
Sbjct: 314 YFCLAS--------NKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVC-RANGNP 364
Query: 272 APSLTWV------RSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTN 325
P++ W+ +S P + V G T+ Y C +N G N
Sbjct: 365 KPTVQWMVNGEPLQSAPPNPNREVA-GDTIIFRDTQISSRAVYQCNTSNEHGYLL---AN 420
Query: 326 IIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSER 385
V L ++P ++ + + ++ C P T WFKNG+
Sbjct: 421 AFVSVLDVPPRMLSPR--NQLIRVILYNRTRLDCPFFGSPIP--TLRWFKNGQGSNLDGG 476
Query: 386 MVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVAS-LKGGGISDISIDVNISSSTVPPNL 444
+ +L+I ++ D G YTCVA+ + G + + ++V +
Sbjct: 477 NYHVYENG-------SLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIY---- 525
Query: 445 TVPQEKSPLVTREGDTIELQCQVTGKP--KPIILWSRADKEVAMPDGSMQMESYDGTLRI 502
+P+++ V R G T++L+C+V P K + W + D+ + + + +M+ D +L I
Sbjct: 526 RMPEDQ---VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGN---RMKKEDDSLTI 579
Query: 503 VNVSREMSGMYRCQTS 518
V+ G Y C S
Sbjct: 580 FGVAERDQGSYTCVAS 595
Score = 58.2 bits (139), Expect = 4e-08
Identities = 104/429 (24%), Positives = 159/429 (37%), Gaps = 56/429 (13%)
Query: 216 CIASVRNVCNIP-DKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPS 274
C+ S+ IP D + L T P+I +V+P + I + C G PAPS
Sbjct: 17 CLLSLGGAIEIPMDPSIQNEL---TQPPTITKQSAKDHIVDPRDNILIECEAKGN-PAPS 72
Query: 275 LTWVRS---FGTLPEKTVL---NGGTLTIPAITS----DDAGTYSCIANNNVGNPAKKST 324
W R+ F + V GTL I + + G Y C A N G +
Sbjct: 73 FHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTAL---S 129
Query: 325 NIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPS-EELTFSWFKNGRPLRSS 383
N I + K W P D + + ++ Q P W SS
Sbjct: 130 NRIRLQVSKSPLW----PKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM-------SS 178
Query: 384 ERMVITQTDPDVSPGTT-NLDIIDLKFTDFGT-YTCVA------SLKGGGISDISIDVNI 435
ITQ D VS G +L ++ D T Y+C A +++ + +
Sbjct: 179 SMEPITQ-DKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTR 237
Query: 436 SSSTVPPNLTVPQ--EKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQM 493
+ P+ PQ S +V R D + L+C +G P P I W + + +P +
Sbjct: 238 GVAERTPSFMYPQGTASSQMVLRGMDLL-LECIASGVPTPDIAWYKKGGD--LPSDKAKF 294
Query: 494 ESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV-EPAFLEIRQG 552
E+++ LRI NVS E SG Y C S G R + + P + EP L + G
Sbjct: 295 ENFNKALRITNVSEEDSGEYFCLASNKMG---SIRHTISVRVKAAPYWLDEPKNLILAPG 351
Query: 553 QDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYT---EYAVKSLSNENYGVY 609
+D + V RA T +W + + L++ + + + VY
Sbjct: 352 EDGRL-----VCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVY 406
Query: 610 NCSIINEAG 618
C+ NE G
Sbjct: 407 QCNTSNEHG 415
Score = 44.3 bits (103), Expect = 6e-04
Identities = 62/276 (22%), Positives = 105/276 (38%), Gaps = 28/276 (10%)
Query: 55 GETLELTCLVTGHPRPQIRWTKTAG--SASDRFQDSSVFNETLRITNIQRHQGGRYYCKA 112
GE L C G+P+P ++W ++ + V +T+ + Q Y C
Sbjct: 351 GEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNT 410
Query: 113 ENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSW- 171
N G + V LD P + + Y RT L C +P W
Sbjct: 411 SNEHGYLLANAF---VSVLDVPPRMLSPR-NQLIRVILYNRTR-LDCPFFGSPIPTLRWF 465
Query: 172 RRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMV 231
+ GQ L G + V E L++K +R +D Y+C+A+ N+ + V
Sbjct: 466 KNGQGSNLDGGNYHVY---------ENGSLEIKMIRKEDQGIYTCVAT--NILGKAENQV 514
Query: 232 SFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLT--WVRSFGTL--PEK 287
+ + T I + +D V G + L C +P+ LT W++ L +
Sbjct: 515 RLEVKDPTR---IYRMPEDQ-VARRGTTVQLEC-RVKHDPSLKLTVSWLKDDEPLYIGNR 569
Query: 288 TVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKS 323
+LTI + D G+Y+C+A+ + K+
Sbjct: 570 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKA 605
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,267,887
Number of Sequences: 37866
Number of extensions: 1855427
Number of successful extensions: 10630
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 223
Number of HSP's successfully gapped in prelim test: 241
Number of HSP's that attempted gapping in prelim test: 4008
Number of HSP's gapped (non-prelim): 3452
length of query: 956
length of database: 18,247,518
effective HSP length: 112
effective length of query: 844
effective length of database: 14,006,526
effective search space: 11821507944
effective search space used: 11821507944
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.