Guide to the Human Genome
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Search of human proteins with 164565366

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|164565366 TBC1 domain family, member 14 isoform a [Homo
sapiens]
         (693 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]  1393   0.0  
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]  1393   0.0  
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]   841   0.0  
gi|148806902 TBC1 domain family, member 12 [Homo sapiens]             663   0.0  
gi|68299759 ecotropic viral integration site 5 [Homo sapiens]         107   4e-23
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]           107   5e-23
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo...   106   6e-23
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]              104   2e-22
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]            104   2e-22
gi|229577000 ecotropic viral integration site 5-like isoform 1 [...   103   7e-22
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H...   103   7e-22
gi|114688046 TBC1 domain family, member 4 [Homo sapiens]               99   2e-20
gi|13994322 TBC1 domain family, member 10A [Homo sapiens]              95   2e-19
gi|167614488 TBC1 domain family, member 10B [Homo sapiens]             92   2e-18
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member...    89   1e-17
gi|38348348 TBC1 domain family, member 10C [Homo sapiens]              87   7e-17
gi|29648315 small G protein signaling modulator 3 [Homo sapiens]       86   2e-16
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]    83   1e-15
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]    83   1e-15
gi|226693407 TBC1 domain family, member 3H [Homo sapiens]              77   4e-14
gi|157502205 TBC1 domain family, member 3G [Homo sapiens]              77   4e-14
gi|183583565 TBC1 domain family, member 3 [Homo sapiens]               77   5e-14
gi|183583567 TBC1 domain family, member 3E [Homo sapiens]              77   5e-14
gi|183583563 TBC1 domain family, member 3D [Homo sapiens]              77   5e-14
gi|14149985 TBC1 domain family, member 3F [Homo sapiens]               77   7e-14
gi|90577185 TBC1 domain family member 3C [Homo sapiens]                74   3e-13
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso...    73   8e-13
gi|149999613 TBC1 domain family, member 3B [Homo sapiens]              73   1e-12
gi|109638751 ubiquitin specific protease 6 [Homo sapiens]              72   2e-12
gi|222352143 TBC1 domain family, member 2 [Homo sapiens]               67   6e-11

>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
          Length = 693

 Score = 1393 bits (3606), Expect = 0.0
 Identities = 693/693 (100%), Positives = 693/693 (100%)

Query: 1   MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHS 60
           MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHS
Sbjct: 1   MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHS 60

Query: 61  LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER 120
           LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
Sbjct: 61  LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER 120

Query: 121 EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL 180
           EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
Sbjct: 121 EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL 180

Query: 181 VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA 240
           VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
Sbjct: 181 VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA 240

Query: 241 RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV 300
           RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
Sbjct: 241 RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV 300

Query: 301 RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL 360
           RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
Sbjct: 301 RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL 360

Query: 361 EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN 420
           EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
Sbjct: 361 EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN 420

Query: 421 ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF 480
           ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
Sbjct: 421 ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF 480

Query: 481 QQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM 540
           QQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM
Sbjct: 481 QQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM 540

Query: 541 AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA 600
           AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA
Sbjct: 541 AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA 600

Query: 601 CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT 660
           CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT
Sbjct: 601 CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT 660

Query: 661 IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH 693
           IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH
Sbjct: 661 IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH 693


>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
          Length = 693

 Score = 1393 bits (3606), Expect = 0.0
 Identities = 693/693 (100%), Positives = 693/693 (100%)

Query: 1   MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHS 60
           MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHS
Sbjct: 1   MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHS 60

Query: 61  LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER 120
           LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
Sbjct: 61  LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER 120

Query: 121 EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL 180
           EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
Sbjct: 121 EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL 180

Query: 181 VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA 240
           VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
Sbjct: 181 VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA 240

Query: 241 RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV 300
           RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
Sbjct: 241 RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV 300

Query: 301 RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL 360
           RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
Sbjct: 301 RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL 360

Query: 361 EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN 420
           EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
Sbjct: 361 EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN 420

Query: 421 ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF 480
           ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
Sbjct: 421 ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF 480

Query: 481 QQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM 540
           QQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM
Sbjct: 481 QQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM 540

Query: 541 AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA 600
           AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA
Sbjct: 541 AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA 600

Query: 601 CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT 660
           CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT
Sbjct: 601 CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT 660

Query: 661 IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH 693
           IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH
Sbjct: 661 IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH 693


>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
          Length = 413

 Score =  841 bits (2173), Expect = 0.0
 Identities = 412/412 (100%), Positives = 412/412 (100%)

Query: 282 EYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEM 341
           EYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEM
Sbjct: 2   EYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEM 61

Query: 342 VVQAKKRELKEAQRRKKQLEERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQG 401
           VVQAKKRELKEAQRRKKQLEERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQG
Sbjct: 62  VVQAKKRELKEAQRRKKQLEERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQG 121

Query: 402 IPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREA 461
           IPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREA
Sbjct: 122 IPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREA 181

Query: 462 SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNL 521
           SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNL
Sbjct: 182 SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNL 241

Query: 522 DTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDI 581
           DTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDI
Sbjct: 242 DTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDI 301

Query: 582 YLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQF 641
           YLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQF
Sbjct: 302 YLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQF 361

Query: 642 LTRLPEDLPAEELFASIATIQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH 693
           LTRLPEDLPAEELFASIATIQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH
Sbjct: 362 LTRLPEDLPAEELFASIATIQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH 413


>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
          Length = 775

 Score =  663 bits (1710), Expect = 0.0
 Identities = 325/462 (70%), Positives = 387/462 (83%), Gaps = 5/462 (1%)

Query: 233 GPFSNFFARNLLARK-QSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPS 291
           G F++FF RNL  ++ +  +   H+  GWKLFGK P REN QK SK IQ+EYE + GR  
Sbjct: 316 GGFADFFTRNLFPKRTKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTC 375

Query: 292 KPPSPKQNVRKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELK 351
           KPP P+ + RKN +FEPLSTTALILEDRP+NLPAK  EEA +HRQ+Y+EMV +AKKRE+K
Sbjct: 376 KPP-PQSSRRKNFEFEPLSTTALILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIK 434

Query: 352 EAQRRKKQLEERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVW 411
           EA +RK+ ++ER + EE+I +A++ W NEILPNWE M  +R+VR+LWWQG+PPSVRGKVW
Sbjct: 435 EAHKRKRIMKERFKQEENIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVW 494

Query: 412 SLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDIS 471
           SLA+GNELNIT EL++I L+RAKERW+S S   SE  N+  G S ADREASLELIKLDIS
Sbjct: 495 SLAVGNELNITPELYEIFLSRAKERWKSFSETSSE--NDTEGVSVADREASLELIKLDIS 552

Query: 472 RTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFS 531
           RTFP+L IFQ+GGPYHD+LHSILGAYTCYRPDVGYVQGMSFIAAVLILNL+ ADAFIAF+
Sbjct: 553 RTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFA 612

Query: 532 NLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLY 591
           NLLNKPCQ+AFFRVDH +ML YFA FEVFFEENL KLF HFK  +LTPDIYLIDWIFTLY
Sbjct: 613 NLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLY 672

Query: 592 SKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPA 651
           SKSLPLDLACR+WDVFCRDGEEFLFRT LGIL+L+EDIL +MDFIH+AQFLT+LPED+ +
Sbjct: 673 SKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITS 732

Query: 652 EELFASIATIQMQSRNKKWAQVLTALQKDSREMEK-GSPSLR 692
           E+LF+ IA IQMQ+  KKW QV  ++ KD +E +K  SP+L+
Sbjct: 733 EKLFSCIAAIQMQNSTKKWTQVFASVMKDIKEGDKNSSPALK 774


>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
          Length = 810

 Score =  107 bits (267), Expect = 4e-23
 Identities = 97/412 (23%), Positives = 178/412 (43%), Gaps = 49/412 (11%)

Query: 291 SKPPSPKQNVRKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKREL 350
           S+  SP  ++        LST AL     P+ L     E   K  +Q   +   +K    
Sbjct: 47  SQVASPSTSLHTTSSSTTLSTPALS-PSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRS 105

Query: 351 KEAQRRKK--QLEERCRVEESIGN----AVLTWNNEILPNWETMWCSRK--VRDLWWQGI 402
               RR     L        ++ +    + + W   I+  WE +   ++  V++L  +GI
Sbjct: 106 VNGSRRNSGSSLVSSSSASSNLSHLEEDSWILWGR-IVNEWEDVRKKKEKQVKELVHKGI 164

Query: 403 PPSVRGKVWSLAIGNELNITHELFDICLARA---KERWRSLSTGGSEVENEDAGFSAADR 459
           P   R  VW L              +C A++   K+++  L    S  E           
Sbjct: 165 PHHFRAIVWQL--------------LCSAQSMPIKDQYSELLKMTSPCE----------- 199

Query: 460 EASLELIKLDISRTFPNLCIFQQGGPY-HDMLHSILGAYTCYRPDVGYVQGMSFIAAVLI 518
               +LI+ DI+RT+P    F++      ++L +++ AY+    +VGY QG +FI  +L+
Sbjct: 200 ----KLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLL 255

Query: 519 LNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLT 578
           + +   +AF  F  L+        F+     +      FE   +E+LP+LF HF+  +  
Sbjct: 256 MQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFH 315

Query: 579 PDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHM 638
             +Y   W  T++  + PL +A RI+D+F  +G E +FR  L +L++ +  L ++D   M
Sbjct: 316 TSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEGM 375

Query: 639 AQFLTRLP----EDLPAEELFASIATIQMQSRNKKWAQVLTALQKDSREMEK 686
            Q   ++     + +P + + A+        + KK  +  T ++  ++EME+
Sbjct: 376 LQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIK--TKEMEE 425


>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
          Length = 1069

 Score =  107 bits (266), Expect = 5e-23
 Identities = 93/361 (25%), Positives = 147/361 (40%), Gaps = 29/361 (8%)

Query: 297 KQNVRKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRR 356
           KQ  RKN          L  E          +   +  +   +  V+ +   + +E    
Sbjct: 460 KQRERKNNTDTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDND 519

Query: 357 KKQLEERCRVEESIGNAVLTWNNEILPNWETMWCSR--KVRDLWWQGIPPSVRGKVWSLA 414
           +  L     V +     +L    E+L  W      R  ++  L   G+P ++RG+VW L 
Sbjct: 520 EPLLSGSGDVSKECAEKILETWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLL 579

Query: 415 IGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTF 474
            G   N              E++R L T  S  ++                I  DI+RTF
Sbjct: 580 AGCHNN----------DHLVEKYRILITKESPQDSA---------------ITRDINRTF 614

Query: 475 PNLCIFQQ-GGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNL 533
           P    F+  GG   D L+ I  AY+ Y  ++GY QG SF+AAVL+L++    AF     +
Sbjct: 615 PAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKI 674

Query: 534 LNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSK 593
           +        F+ +   +   F   E   +E +P L+ HF   +L   +Y   W  TL++ 
Sbjct: 675 MFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTA 734

Query: 594 SLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFL-TRLPEDLPAE 652
             PL +   I D+   +G   +F  ALG+LK  +D L   DF    +F   +LP+   +E
Sbjct: 735 KFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSE 794

Query: 653 E 653
           E
Sbjct: 795 E 795


>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
           sapiens]
          Length = 815

 Score =  106 bits (265), Expect = 6e-23
 Identities = 82/278 (29%), Positives = 124/278 (44%), Gaps = 29/278 (10%)

Query: 380 EILPNWETMWCSRK--VRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERW 437
           E+L  W +   +R   +  L   G+P ++R +VW L  G   N              +R+
Sbjct: 515 ELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDN----------QAMLDRY 564

Query: 438 RSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQ-GGPYHDMLHSILGA 496
           R L T  S  E+               +I  DI RTFP    F+  GG   + L+ I  A
Sbjct: 565 RILITKDSAQES---------------VITRDIHRTFPAHDYFKDTGGDGQESLYKICKA 609

Query: 497 YTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAA 556
           Y+ Y  D+GY QG SF+AAVL+L++    AF     ++        +R +   +   F  
Sbjct: 610 YSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQ 669

Query: 557 FEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLF 616
            E   +E LP L +HF   NL   +Y   W  TL++   PL +   I D+   +G   +F
Sbjct: 670 LERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIF 729

Query: 617 RTALGILKLFEDILTKMDFIHMAQFL-TRLPEDLPAEE 653
             AL +LK  ++ L + DF    +F   +LP+   AEE
Sbjct: 730 HVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEE 767


>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
          Length = 828

 Score =  104 bits (260), Expect = 2e-22
 Identities = 84/298 (28%), Positives = 134/298 (44%), Gaps = 26/298 (8%)

Query: 380 EILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRS 439
           ++L  WE    + K     ++GIP  +RG+VW+L +              + + KE  R 
Sbjct: 79  KMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLE-------------IPKMKEETRD 125

Query: 440 LSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQG-GPYHDMLHSILGAYT 498
           L    S++++   G S   R+     I LD++RTF +  +F+   G     L  +L AY+
Sbjct: 126 LY---SKLKHRARGCSPDIRQ-----IDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYS 177

Query: 499 CYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKP--CQMAFFRVDHGLMLTYFAA 556
            Y  +VGY QGMS I A+L++ ++  DAF A   L + P      FF      +L +   
Sbjct: 178 IYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEH 237

Query: 557 FEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLF 616
            E    + L KL  H     +    Y + W F  +    P  L  RIWD++  +GE  L 
Sbjct: 238 HEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLT 297

Query: 617 RTALGILKLFEDILTKMDFIHMAQFLTR-LPEDLPAEELFASIATIQMQSRNKKWAQV 673
             +  ILKL +  L K+    + +F    L +D   E+ F  I  +Q+     K A++
Sbjct: 298 AMSYTILKLHKKHLMKLSMEELVEFFQETLAKDFFFEDDFV-IEQLQISMTELKRAKL 354


>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
          Length = 845

 Score =  104 bits (260), Expect = 2e-22
 Identities = 84/298 (28%), Positives = 134/298 (44%), Gaps = 26/298 (8%)

Query: 380 EILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRS 439
           ++L  WE    + K     ++GIP  +RG+VW+L +              + + KE  R 
Sbjct: 96  KMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLE-------------IPKMKEETRD 142

Query: 440 LSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQG-GPYHDMLHSILGAYT 498
           L    S++++   G S   R+     I LD++RTF +  +F+   G     L  +L AY+
Sbjct: 143 LY---SKLKHRARGCSPDIRQ-----IDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYS 194

Query: 499 CYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKP--CQMAFFRVDHGLMLTYFAA 556
            Y  +VGY QGMS I A+L++ ++  DAF A   L + P      FF      +L +   
Sbjct: 195 IYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEH 254

Query: 557 FEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLF 616
            E    + L KL  H     +    Y + W F  +    P  L  RIWD++  +GE  L 
Sbjct: 255 HEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLT 314

Query: 617 RTALGILKLFEDILTKMDFIHMAQFLTR-LPEDLPAEELFASIATIQMQSRNKKWAQV 673
             +  ILKL +  L K+    + +F    L +D   E+ F  I  +Q+     K A++
Sbjct: 315 AMSYTILKLHKKHLMKLSMEELVEFFQETLAKDFFFEDDFV-IEQLQISMTELKRAKL 371


>gi|229577000 ecotropic viral integration site 5-like isoform 1
           [Homo sapiens]
          Length = 805

 Score =  103 bits (256), Expect = 7e-22
 Identities = 84/316 (26%), Positives = 142/316 (44%), Gaps = 41/316 (12%)

Query: 381 ILPNWETMWCSRK---VRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLAR---AK 434
           I   WE  W  RK   +++L  +GIP   R  VW L              +C A     K
Sbjct: 93  IANEWEE-WRRRKEKLLKELIRKGIPHHFRAIVWQL--------------LCSATDMPVK 137

Query: 435 ERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQ-QGGPYHDMLHSI 493
            ++  L    S  E               +LI+ DI+RT+P    F+ Q     ++L ++
Sbjct: 138 NQYSELLKMSSPCE---------------KLIRRDIARTYPEHEFFKGQDSLGQEVLFNV 182

Query: 494 LGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTY 553
           + AY+    +VGY QG +FI  +L++ +   +AF  F  L+ +      F+     +   
Sbjct: 183 MKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLC 242

Query: 554 FAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEE 613
              FE   +E LP L  HF+  +    +Y   W  TL+  + PL +A R++D+F  +G E
Sbjct: 243 IYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLE 302

Query: 614 FLFRTALGILKLFEDILTKMDFIHMAQFLTR-LPE--DLPAEELFASIATIQMQSRNKKW 670
            +FR  L +L++ +  L ++D   M+Q+  R +P   D   ++L      ++   +  K 
Sbjct: 303 IVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKR 362

Query: 671 AQVLTALQKDSREMEK 686
            +   A  K S+EME+
Sbjct: 363 LEKEYAAMK-SKEMEE 377


>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
           sapiens]
          Length = 794

 Score =  103 bits (256), Expect = 7e-22
 Identities = 84/316 (26%), Positives = 142/316 (44%), Gaps = 41/316 (12%)

Query: 381 ILPNWETMWCSRK---VRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLAR---AK 434
           I   WE  W  RK   +++L  +GIP   R  VW L              +C A     K
Sbjct: 93  IANEWEE-WRRRKEKLLKELIRKGIPHHFRAIVWQL--------------LCSATDMPVK 137

Query: 435 ERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQ-QGGPYHDMLHSI 493
            ++  L    S  E               +LI+ DI+RT+P    F+ Q     ++L ++
Sbjct: 138 NQYSELLKMSSPCE---------------KLIRRDIARTYPEHEFFKGQDSLGQEVLFNV 182

Query: 494 LGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTY 553
           + AY+    +VGY QG +FI  +L++ +   +AF  F  L+ +      F+     +   
Sbjct: 183 MKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLC 242

Query: 554 FAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEE 613
              FE   +E LP L  HF+  +    +Y   W  TL+  + PL +A R++D+F  +G E
Sbjct: 243 IYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLE 302

Query: 614 FLFRTALGILKLFEDILTKMDFIHMAQFLTR-LPE--DLPAEELFASIATIQMQSRNKKW 670
            +FR  L +L++ +  L ++D   M+Q+  R +P   D   ++L      ++   +  K 
Sbjct: 303 IVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKR 362

Query: 671 AQVLTALQKDSREMEK 686
            +   A  K S+EME+
Sbjct: 363 LEKEYAAMK-SKEMEE 377


>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
          Length = 1298

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 76/325 (23%), Positives = 146/325 (44%), Gaps = 28/325 (8%)

Query: 335  RQQYEEMVVQAKKRELKEAQRRKKQLEERCRVEESIGNAVLTWNNEILPNWETMWCSRK- 393
            R + E   ++A + EL ++++ K   EE    ++ +   ++TW+ ++L     + C  + 
Sbjct: 855  RMEKENQKLEASRDEL-QSRKVKLDYEEVGACQKEV---LITWDKKLLNCRAKIRCDMED 910

Query: 394  VRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAG 453
            +  L  +G+P S RG++W   +  +  + H L                   ++ +  D  
Sbjct: 911  IHTLLKEGVPKSRRGEIWQF-LALQYRLRHRL------------------PNKQQPPDIS 951

Query: 454  FSAADRE--ASLELIKLDISRTFPNLCIFQ-QGGPYHDMLHSILGAYTCYRPDVGYVQGM 510
            +    ++  A    I +D+ RTFP    F  Q GP    L ++L AY+    +VGY QG+
Sbjct: 952  YKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGI 1011

Query: 511  SFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFA 570
            SF+A VL+L++    AF     L+        +R D   +            +    L+ 
Sbjct: 1012 SFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYN 1071

Query: 571  HFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDIL 630
            H ++N ++P +Y   W  TL++    L    R++D+    G E +F+ AL +L   E ++
Sbjct: 1072 HLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLI 1131

Query: 631  TKMD-FIHMAQFLTRLPEDLPAEEL 654
             + + F ++ +FL     D+   E+
Sbjct: 1132 MECESFENIVEFLKNTLPDMNTSEM 1156


>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
          Length = 508

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 63/251 (25%), Positives = 113/251 (45%), Gaps = 32/251 (12%)

Query: 380 EILPNWETMWCSR--KVRDLWWQGIPPSVRGKVWSLAIGNELNITH---ELFDICLARAK 434
           ++L NW+     +  K+R    +GIPPS+RG+ W    G ++ +     +  ++ ++   
Sbjct: 88  DMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGD 147

Query: 435 ERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF-QQGGPYHDMLHSI 493
            +W                         L++I+ D+ R FP   +F  +GG     L  +
Sbjct: 148 PKW-------------------------LDVIERDLHRQFPFHEMFVSRGGHGQQDLFRV 182

Query: 494 LGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTY 553
           L AYT YRP+ GY Q  + IAAVL++++    AF     +  K     +      + L  
Sbjct: 183 LKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDG 242

Query: 554 FAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEE 613
              F +  ++  P    H  +  + P +Y+ +W    +S++LP     R+WD+F  +G +
Sbjct: 243 EILFSLL-QKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVK 301

Query: 614 FLFRTALGILK 624
            +FR  L +LK
Sbjct: 302 IIFRVGLVLLK 312


>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
          Length = 808

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 69/256 (26%), Positives = 113/256 (44%), Gaps = 42/256 (16%)

Query: 380 EILPNWETMWCSR---KVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKER 436
           ++  NW+  W SR   KV+    +GIP S+R K W                         
Sbjct: 337 DMFSNWDK-WLSRRFQKVKLRCRKGIPSSLRAKAWQY----------------------- 372

Query: 437 WRSLSTGGSEVENEDAGFSAADREAS----LELIKLDISRTFPNLCIFQ-QGGPYHDMLH 491
              LS     +E     F   +R       L++I+ D+ R FP   +F  +GG     L+
Sbjct: 373 ---LSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLY 429

Query: 492 SILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLML 551
            IL AYT YRPD GY Q  + +AAVL++++    AF     + +K     +      + L
Sbjct: 430 RILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQL 489

Query: 552 TYFAAFEVFF---EENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFC 608
                 E+FF       P    H ++  + P +Y+ +W   +++++LP     R+WD+F 
Sbjct: 490 DG----EIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFF 545

Query: 609 RDGEEFLFRTALGILK 624
            +G + +FR AL +L+
Sbjct: 546 CEGVKIIFRVALVLLR 561


>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
            [Homo sapiens]
          Length = 1168

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 76/356 (21%), Positives = 148/356 (41%), Gaps = 43/356 (12%)

Query: 305  DFEPLSTTALILEDRPANLPAKPAEEAQKH-RQQYEEMVVQAKKRELKEAQRRKKQLEER 363
            +  P S    + ED P   P +  +   +  R+ +++ ++Q       E + +K Q  E 
Sbjct: 690  ELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASEN 749

Query: 364  CRVEESIG---NAVLTWNNEILPNWETMWCS----------RKVRDLWWQGIPPSVRGKV 410
              + + +      +     E+   WE M  +           K+     QG+P   RG++
Sbjct: 750  DLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEI 809

Query: 411  WSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLE--LIKL 468
            W   +  + ++ H+                    S+ + +D  +    ++ + +   I +
Sbjct: 810  WKF-LAEQFHLKHQF------------------PSKQQPKDVPYKELLKQLTSQQHAILI 850

Query: 469  DISRTFPNLCIFQ-QGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAF 527
            D+ RTFP    F  Q G     L++IL AY+    +VGY QG+SF+A +L+L++   +AF
Sbjct: 851  DLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAF 910

Query: 528  IAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWI 587
                 L+        +R D  ++            +    L+ H +++ + P +Y   W 
Sbjct: 911  KMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWF 970

Query: 588  FTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGIL-------KLFEDILTKMDFI 636
             T+++   PL    R++D+    G E +F+ AL +L          E++ T +DFI
Sbjct: 971  LTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFI 1026


>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
          Length = 446

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 64/253 (25%), Positives = 110/253 (43%), Gaps = 34/253 (13%)

Query: 380 EILPNWETMWCSR--KVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERW 437
           E+  +WE     R  KV+    +GIP ++R + W L  G           +C   +   +
Sbjct: 69  EMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAH---------VCQKNSPGTY 119

Query: 438 RSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFP--NLCIFQQGGPYHDMLHSILG 495
           + L+    + +              +E I  D+ R FP   + +  QG     +L  +L 
Sbjct: 120 QELAEAPGDPQ-------------WMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQ-VLK 165

Query: 496 AYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM---AFFRVDHGLMLT 552
           AYT YRP+ GY Q    +AAVL+++L   +AF     +    C++    ++      +  
Sbjct: 166 AYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQI----CEVYLPGYYGPHMEAVRL 221

Query: 553 YFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGE 612
               F       LP +  H ++  + P +YL +W   L+++SLP     R+WD F  +G 
Sbjct: 222 DAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGA 281

Query: 613 EFLFRTALGILKL 625
             LFR  L +++L
Sbjct: 282 RVLFRVGLTLVRL 294


>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
          Length = 749

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 69/271 (25%), Positives = 116/271 (42%), Gaps = 22/271 (8%)

Query: 391 SRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENE 450
           S K+R L   GIP  +R ++W    G              A  K+R   LS        E
Sbjct: 104 SEKLRSLVLAGIPHGMRPQLWMRLSG--------------ALQKKRNSELSY------RE 143

Query: 451 DAGFSAADREASLELIKLDISRTFP-NLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQG 509
               S+ D   + + I+ D+ RT P N C    G      L  +L A     P++GY QG
Sbjct: 144 IVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQG 203

Query: 510 MSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLF 569
              +AA L+L L+  DAF   S ++      ++F      + T          + LP+L 
Sbjct: 204 TGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLD 263

Query: 570 AHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKL-FED 628
              +++++   +  + W  T ++  + + L  RIWD+F  +G   LF+  LG+L L  E+
Sbjct: 264 KLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEE 323

Query: 629 ILTKMDFIHMAQFLTRLPEDLPAEELFASIA 659
           ++   +   +   L+ +P  +   EL   +A
Sbjct: 324 LIQSENSASIFNTLSDIPSQMEDAELLLGVA 354


>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
          Length = 963

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 64/255 (25%), Positives = 107/255 (41%), Gaps = 34/255 (13%)

Query: 388 MWCSRKVRDLWWQGIPPSVRGKVWSLAIGNEL-----NITHELFDICLARAKERWRSLST 442
           M CS ++++L   GIP   R KVW   +         N     F   L +A E+    S 
Sbjct: 649 MMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPAS- 707

Query: 443 GGSEVENEDAGFSAADREASLELIKLDISRTFPN----LCIFQQGGPYHDMLHSILGAYT 498
                                + I+LD+ RT PN     C   +G      L ++L A++
Sbjct: 708 ---------------------KQIELDLLRTLPNNKHYSCPTSEG---IQKLRNVLLAFS 743

Query: 499 CYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFE 558
              PD+GY QG++ + AV +L L+  DAF     ++       ++             F 
Sbjct: 744 WRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFR 803

Query: 559 VFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRT 618
               E LP+L  HF++  +   +   +W   ++  S+  D+  +IWD F  +G + +FR 
Sbjct: 804 DLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRF 863

Query: 619 ALGILKLFEDILTKM 633
           AL + K  E+ + K+
Sbjct: 864 ALALFKYKEEEILKL 878


>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
          Length = 914

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 64/255 (25%), Positives = 107/255 (41%), Gaps = 34/255 (13%)

Query: 388 MWCSRKVRDLWWQGIPPSVRGKVWSLAIGNEL-----NITHELFDICLARAKERWRSLST 442
           M CS ++++L   GIP   R KVW   +         N     F   L +A E+    S 
Sbjct: 649 MMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPAS- 707

Query: 443 GGSEVENEDAGFSAADREASLELIKLDISRTFPN----LCIFQQGGPYHDMLHSILGAYT 498
                                + I+LD+ RT PN     C   +G      L ++L A++
Sbjct: 708 ---------------------KQIELDLLRTLPNNKHYSCPTSEG---IQKLRNVLLAFS 743

Query: 499 CYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFE 558
              PD+GY QG++ + AV +L L+  DAF     ++       ++             F 
Sbjct: 744 WRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFR 803

Query: 559 VFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRT 618
               E LP+L  HF++  +   +   +W   ++  S+  D+  +IWD F  +G + +FR 
Sbjct: 804 DLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRF 863

Query: 619 ALGILKLFEDILTKM 633
           AL + K  E+ + K+
Sbjct: 864 ALALFKYKEEEILKL 878


>gi|226693407 TBC1 domain family, member 3H [Homo sapiens]
          Length = 549

 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 70/257 (27%), Positives = 112/257 (43%), Gaps = 26/257 (10%)

Query: 380 EILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRS 439
           ++L +WE    SRK+ D  ++G+P ++RG +WS+     LNI             E  + 
Sbjct: 80  DMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVL----LNI-------------EEMKL 122

Query: 440 LSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQ--GGPYHDMLHSILGAY 497
            + G  ++  E    S+      ++ I  DIS T      F+   G    ++LH +L AY
Sbjct: 123 KNPGRYQIMKEKGKRSSEH----IQRIDRDISGTLRKHMFFRDRYGTKQRELLHILL-AY 177

Query: 498 TCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLL--NKPCQMAFFRVDHGLMLTYFA 555
             Y P+VGY + +S IAA+ +L L   DAF A   LL   +     F   + G +     
Sbjct: 178 EEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQD 237

Query: 556 AFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFL 615
             E     + PK   H  K +L      +  +  +    + L L  R+WDV+  +GE+ L
Sbjct: 238 QQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQAL 297

Query: 616 FRTALGILKLFEDILTK 632
                   K+ +  LTK
Sbjct: 298 MPITRIAFKVQQKRLTK 314


>gi|157502205 TBC1 domain family, member 3G [Homo sapiens]
          Length = 549

 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 70/257 (27%), Positives = 112/257 (43%), Gaps = 26/257 (10%)

Query: 380 EILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRS 439
           ++L +WE    SRK+ D  ++G+P ++RG +WS+     LNI             E  + 
Sbjct: 80  DMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVL----LNI-------------EEMKL 122

Query: 440 LSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQ--GGPYHDMLHSILGAY 497
            + G  ++  E    S+      ++ I  DIS T      F+   G    ++LH +L AY
Sbjct: 123 KNPGRYQIMKEKGKRSSEH----IQRIDRDISGTLRKHMFFRDRYGTKQRELLHILL-AY 177

Query: 498 TCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLL--NKPCQMAFFRVDHGLMLTYFA 555
             Y P+VGY + +S IAA+ +L L   DAF A   LL   +     F   + G +     
Sbjct: 178 EEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQD 237

Query: 556 AFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFL 615
             E     + PK   H  K +L      +  +  +    + L L  R+WDV+  +GE+ L
Sbjct: 238 QQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQAL 297

Query: 616 FRTALGILKLFEDILTK 632
                   K+ +  LTK
Sbjct: 298 MPITRIAFKVQQKRLTK 314


>gi|183583565 TBC1 domain family, member 3 [Homo sapiens]
          Length = 549

 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 69/257 (26%), Positives = 112/257 (43%), Gaps = 26/257 (10%)

Query: 380 EILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRS 439
           ++L +WE    SRK+ D  ++G+P ++RG +WS+     LNI             E  + 
Sbjct: 80  DMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVL----LNI-------------EEMKL 122

Query: 440 LSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQ--GGPYHDMLHSILGAY 497
            + G  ++  E    S+      ++ I  D+S T      F+   G    ++LH +L AY
Sbjct: 123 KNPGRYQIMKEKGKRSSEH----IQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILL-AY 177

Query: 498 TCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLL--NKPCQMAFFRVDHGLMLTYFA 555
             Y P+VGY + +S IAA+ +L L   DAF A   LL   +     F   + G +     
Sbjct: 178 EEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQD 237

Query: 556 AFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFL 615
             E     + PK   H  K +L      +  +  +    + L L  R+WDV+  +GE+ L
Sbjct: 238 QQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQAL 297

Query: 616 FRTALGILKLFEDILTK 632
                   K+ +  LTK
Sbjct: 298 MPITRIAFKVQQKRLTK 314


>gi|183583567 TBC1 domain family, member 3E [Homo sapiens]
          Length = 549

 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 69/257 (26%), Positives = 112/257 (43%), Gaps = 26/257 (10%)

Query: 380 EILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRS 439
           ++L +WE    SRK+ D  ++G+P ++RG +WS+     LNI             E  + 
Sbjct: 80  DMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVL----LNI-------------EEMKL 122

Query: 440 LSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQ--GGPYHDMLHSILGAY 497
            + G  ++  E    S+      ++ I  D+S T      F+   G    ++LH +L AY
Sbjct: 123 KNPGRYQIMKEKGKRSSEH----IQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILL-AY 177

Query: 498 TCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLL--NKPCQMAFFRVDHGLMLTYFA 555
             Y P+VGY + +S IAA+ +L L   DAF A   LL   +     F   + G +     
Sbjct: 178 EEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQD 237

Query: 556 AFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFL 615
             E     + PK   H  K +L      +  +  +    + L L  R+WDV+  +GE+ L
Sbjct: 238 QQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQAL 297

Query: 616 FRTALGILKLFEDILTK 632
                   K+ +  LTK
Sbjct: 298 MPITRIAFKVQQKRLTK 314


>gi|183583563 TBC1 domain family, member 3D [Homo sapiens]
          Length = 549

 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 69/257 (26%), Positives = 112/257 (43%), Gaps = 26/257 (10%)

Query: 380 EILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRS 439
           ++L +WE    SRK+ D  ++G+P ++RG +WS+     LNI             E  + 
Sbjct: 80  DMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVL----LNI-------------EEMKL 122

Query: 440 LSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQ--GGPYHDMLHSILGAY 497
            + G  ++  E    S+      ++ I  D+S T      F+   G    ++LH +L AY
Sbjct: 123 KNPGRYQIMKEKGKRSSEH----IQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILL-AY 177

Query: 498 TCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLL--NKPCQMAFFRVDHGLMLTYFA 555
             Y P+VGY + +S IAA+ +L L   DAF A   LL   +     F   + G +     
Sbjct: 178 EEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQD 237

Query: 556 AFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFL 615
             E     + PK   H  K +L      +  +  +    + L L  R+WDV+  +GE+ L
Sbjct: 238 QQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQAL 297

Query: 616 FRTALGILKLFEDILTK 632
                   K+ +  LTK
Sbjct: 298 MPITRIAFKVQQKRLTK 314


>gi|14149985 TBC1 domain family, member 3F [Homo sapiens]
          Length = 549

 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 66/257 (25%), Positives = 110/257 (42%), Gaps = 26/257 (10%)

Query: 380 EILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRS 439
           ++L +WE    SRK+ D  ++G+P ++RG +WS+ +  E                   + 
Sbjct: 80  DMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTE-----------------EMKL 122

Query: 440 LSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQ--GGPYHDMLHSILGAY 497
            + G  ++  E    S+      ++ I  D+S T      F+   G    ++LH +L AY
Sbjct: 123 KNPGRYQIMKEKGKKSSEH----IQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILL-AY 177

Query: 498 TCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLL--NKPCQMAFFRVDHGLMLTYFA 555
             Y P+VGY + +S IAA+ +L L   DAF A   LL   +     F   + G +     
Sbjct: 178 EEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQD 237

Query: 556 AFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFL 615
             E     + PK   H  K +L      +  +  +    + L L  R+WDV+  +GE+ L
Sbjct: 238 QQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQAL 297

Query: 616 FRTALGILKLFEDILTK 632
                   K+ +  LTK
Sbjct: 298 MPITRIAFKVQQKRLTK 314


>gi|90577185 TBC1 domain family member 3C [Homo sapiens]
          Length = 549

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 69/257 (26%), Positives = 111/257 (43%), Gaps = 26/257 (10%)

Query: 380 EILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRS 439
           ++L +WE    SRK+ D  ++G+P ++RG +WS+     LNI             E  + 
Sbjct: 80  DMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVL----LNI-------------EEMKL 122

Query: 440 LSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQ--GGPYHDMLHSILGAY 497
            + G  ++  E    S+      ++ I  DIS T      F+   G    ++LH +L AY
Sbjct: 123 KNPGRYQIMKEKGKRSSEH----IQRIDRDISGTLRKHMFFRDRYGTKQRELLHILL-AY 177

Query: 498 TCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLL--NKPCQMAFFRVDHGLMLTYFA 555
             Y P+VGY + +S IAA+ +L L   DAF A   LL   +     F   + G +     
Sbjct: 178 EEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQD 237

Query: 556 AFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFL 615
             E     +  K   H  K +L      +  +  +    + L L  R+WDV+  +GE+ L
Sbjct: 238 QQEHVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQAL 297

Query: 616 FRTALGILKLFEDILTK 632
                   K+ +  LTK
Sbjct: 298 MPITRIAFKVQQKRLTK 314


>gi|38570101 TBC1 domain family, member 8B (with GRAM domain)
           isoform a [Homo sapiens]
          Length = 1120

 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 67/261 (25%), Positives = 110/261 (42%), Gaps = 28/261 (10%)

Query: 387 TMWCSRKVRDLWWQGIPPSVRGKVWSLAIG--NELNITHELFDICLARAKERWRSLSTGG 444
           +M+ ++K RDL  +GIP ++RG++W L  G  N++    + +                  
Sbjct: 473 SMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYY------------------ 514

Query: 445 SEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDV 504
           +EV  +  G        + E I+ D+ R+ P    FQ        L  +L AY    P +
Sbjct: 515 TEVVEQSLGTC----NLATEEIERDLRRSLPEHPAFQSDTGI-SALRRVLTAYAYRNPKI 569

Query: 505 GYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEEN 564
           GY Q M+ + +VL+L     +AF     +  +     F R   G ++   A FE    ++
Sbjct: 570 GYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQ-AVFEELIRDH 628

Query: 565 LPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILK 624
           LP+L  H         + L  W  TL+   LP++ A  + D F  DG + + +  L IL 
Sbjct: 629 LPQLTEHMTDMTFFSSVSL-SWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILD 687

Query: 625 L-FEDILTKMDFIHMAQFLTR 644
              + +LT  D       L R
Sbjct: 688 YNLDKLLTCKDDAEAVTALNR 708


>gi|149999613 TBC1 domain family, member 3B [Homo sapiens]
          Length = 549

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 68/257 (26%), Positives = 110/257 (42%), Gaps = 26/257 (10%)

Query: 380 EILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRS 439
           ++L +WE    SRK+ D  ++G+P ++RG +WS+     LNI             E  + 
Sbjct: 80  DMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVL----LNI-------------EEMKL 122

Query: 440 LSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQ--GGPYHDMLHSILGAY 497
            + G  ++  E    S+      ++ I  DIS T      F+   G    ++LH +L AY
Sbjct: 123 KNPGRYQIMKEKGKRSSEH----IQRIDRDISGTLRKHMFFRDRYGTKQRELLHILL-AY 177

Query: 498 TCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLL--NKPCQMAFFRVDHGLMLTYFA 555
             Y P+VGY + +S IAA+ +L     DAF A   LL   +     F   + G +     
Sbjct: 178 EEYNPEVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQD 237

Query: 556 AFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFL 615
             E     +  K   H  K +L      +  +  +    + L L  R+WDV+  +GE+ L
Sbjct: 238 QQEHVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQAL 297

Query: 616 FRTALGILKLFEDILTK 632
                   K+ +  LTK
Sbjct: 298 MPITRIAFKVQQKRLTK 314


>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
          Length = 1406

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 71/256 (27%), Positives = 108/256 (42%), Gaps = 24/256 (9%)

Query: 380 EILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRS 439
           E+L  WET   S K+ D  ++GIP ++RG VWS+     LNI             +  + 
Sbjct: 79  EMLGEWETYKHSSKLIDRVYKGIPMNIRGPVWSVL----LNI-------------QEIKL 121

Query: 440 LSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQ-QGGPYHDMLHSILGAYT 498
            + G  ++  E    S+      +  I LD+  T  N   F+ + G     L  IL AY+
Sbjct: 122 KNPGRYQIMKERGKRSS----EHIHHIDLDVRTTLRNHVFFRDRYGAKQRELFYILLAYS 177

Query: 499 CYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLL--NKPCQMAFFRVDHGLMLTYFAA 556
            Y P+VGY + +S I A+ +L L   DAF A   LL   +     F   + G +      
Sbjct: 178 EYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQ 237

Query: 557 FEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLF 616
            E    ++ PK   H  K  L      +  +       + L L  R+WDV+  +GE+ L 
Sbjct: 238 QEHVVPKSQPKTMWHQDKEGLCGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLM 297

Query: 617 RTALGILKLFEDILTK 632
                 LK+ +  L K
Sbjct: 298 PITSIALKVQQKRLMK 313


>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
          Length = 917

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 64/297 (21%), Positives = 121/297 (40%), Gaps = 32/297 (10%)

Query: 391 SRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENE 450
           S +++ L   G+P   R +VW   +   L + H                L T G   E  
Sbjct: 615 SAELKQLLRAGVPREHRPRVWRWLV--HLRVQH----------------LHTPGCYQELL 656

Query: 451 DAGFSAADREASLELIKLDISRTFPNLCIFQ-QGGPYHDMLHSILGAYTCYRPDVGYVQG 509
             G   A    +   I+LD++RTFPN   F      + D L  +L A++   P +GY QG
Sbjct: 657 SRG--QAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQG 714

Query: 510 MSFIAAVLILNLDTAD-AFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKL 568
           ++ +AA+ +L L+  + AF     ++       ++              +    E LP+L
Sbjct: 715 LNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRL 774

Query: 569 FAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFED 628
            AH  ++++   +   +W   +++ SL  ++  R+WD F  +G ++  +          +
Sbjct: 775 MAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTKYNEK----------E 824

Query: 629 ILTKMDFIHMAQFLTRLPEDLPAEELFASIATIQMQSRNKKWAQVLTALQKDSREME 685
           IL   + + + Q+L    + +       +IA   M     K  + L  + ++  E E
Sbjct: 825 ILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAE 881


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,154,381
Number of Sequences: 37866
Number of extensions: 1280117
Number of successful extensions: 6479
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 89
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 5830
Number of HSP's gapped (non-prelim): 700
length of query: 693
length of database: 18,247,518
effective HSP length: 109
effective length of query: 584
effective length of database: 14,120,124
effective search space: 8246152416
effective search space used: 8246152416
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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