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Search of human proteins with 16418343
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
(268 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16418343 testis-specific serine kinase 3 [Homo sapiens] 549 e-157
gi|194294513 testis-specific serine kinase 2 [Homo sapiens] 261 5e-70
gi|14042947 testis-specific serine kinase 1 [Homo sapiens] 254 4e-68
gi|14042966 testis-specific serine kinase 6 [Homo sapiens] 243 1e-64
gi|42734401 testis-specific serine kinase 4 [Homo sapiens] 215 4e-56
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 195 4e-50
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 188 5e-48
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 188 5e-48
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 188 5e-48
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 188 5e-48
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 187 6e-48
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 186 2e-47
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 186 2e-47
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 186 2e-47
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 186 2e-47
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 186 2e-47
gi|116256471 SNF1-like kinase [Homo sapiens] 185 4e-47
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 183 1e-46
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 182 2e-46
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 174 9e-44
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 172 4e-43
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 171 5e-43
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 170 1e-42
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 170 1e-42
gi|156105707 SNF related kinase [Homo sapiens] 170 1e-42
gi|156105705 SNF related kinase [Homo sapiens] 170 1e-42
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 168 5e-42
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 162 3e-40
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 160 1e-39
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 150 1e-36
>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
Length = 268
Score = 549 bits (1415), Expect = e-157
Identities = 268/268 (100%), Positives = 268/268 (100%)
Query: 1 MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQ 60
MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQ
Sbjct: 1 MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQ 60
Query: 61 IVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVE 120
IVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVE
Sbjct: 61 IVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVE 120
Query: 121 AIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEV 180
AIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEV
Sbjct: 121 AIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEV 180
Query: 181 LQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQD 240
LQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQD
Sbjct: 181 LQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQD 240
Query: 241 LLKRLLEPDMILRPSIEEVSWHPWLAST 268
LLKRLLEPDMILRPSIEEVSWHPWLAST
Sbjct: 241 LLKRLLEPDMILRPSIEEVSWHPWLAST 268
>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
Length = 358
Score = 261 bits (667), Expect = 5e-70
Identities = 125/266 (46%), Positives = 189/266 (71%), Gaps = 5/266 (1%)
Query: 5 LLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRT 64
L GY +G +G+G+Y+KVK A+S++ + VA+K+ID+ P +F++RFLPRE+ I+ T
Sbjct: 7 LRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILAT 66
Query: 65 LDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRY 124
++H +II+ YE+ E++DG+I ++MEL GD+ + + G L E A+ +FRQ+ A++Y
Sbjct: 67 VNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKY 126
Query: 125 CHGCGVAHRDLKCENALL-QGFNLKLTDFGFAKVLPKSHRE---LSQTFCGSTAYAAPEV 180
CH + HRDLKCEN LL + FN+KL+DFGF+K + LS+TFCGS AYAAPEV
Sbjct: 127 CHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEV 186
Query: 181 LQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKML-WQQQKGVSFPTHLSISADCQ 239
LQ IP+ K D+WS+GV+LY+M+C S+P+DD+DI KML Q++ V FP +++ +C+
Sbjct: 187 LQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECK 246
Query: 240 DLLKRLLEPDMILRPSIEEVSWHPWL 265
DL+ R+L+PD+ R I+E+ H WL
Sbjct: 247 DLIYRMLQPDVSQRLHIDEILSHSWL 272
>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
Length = 367
Score = 254 bits (650), Expect = 4e-68
Identities = 125/266 (46%), Positives = 185/266 (69%), Gaps = 5/266 (1%)
Query: 5 LLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRT 64
L GY LG +GEG+Y+KVK A+S++ + VAIK+ID+ P +F+++FLPRE++I+
Sbjct: 7 LKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAM 66
Query: 65 LDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRY 124
L+H +II+ YE+ E++ GK+ +VMELA GD+ + + G L E A+ F Q+ AI+Y
Sbjct: 67 LNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKY 126
Query: 125 CHGCGVAHRDLKCENALL-QGFNLKLTDFGFAKVL---PKSHRELSQTFCGSTAYAAPEV 180
CH V HRDLKC+N LL + FN+KL+DF F+K LS+TFCGS AYAAPEV
Sbjct: 127 CHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEV 186
Query: 181 LQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKML-WQQQKGVSFPTHLSISADCQ 239
LQGIP+ K D+WS+GV+LY+M+C S+P+DD++I KML Q++ V+FP ++ +C+
Sbjct: 187 LQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECK 246
Query: 240 DLLKRLLEPDMILRPSIEEVSWHPWL 265
DL+ +L+PD+ R I+E+ H W+
Sbjct: 247 DLIYHMLQPDVNRRLHIDEILSHCWM 272
>gi|14042966 testis-specific serine kinase 6 [Homo sapiens]
Length = 273
Score = 243 bits (620), Expect = 1e-64
Identities = 131/266 (49%), Positives = 179/266 (67%), Gaps = 5/266 (1%)
Query: 3 DFLLSN-GYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQI 61
D LLS GY+LG+TIGEG+YSKVK A SKK++ VAIKV+D+ P +F+ +FLPREL I
Sbjct: 4 DKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSI 63
Query: 62 VRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEA 121
+R + H +I+ V+E +E +GK+ +VME A D+ V G +P +A+ LF Q+ A
Sbjct: 64 LRGVRHPHIVHVFEFIEVCNGKLYIVMEAA-ATDLLQAVQRNGRIPGVQARDLFAQIAGA 122
Query: 122 IRYCHGCGVAHRDLKCENALLQGFN--LKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPE 179
+RY H + HRDLKCEN LL +KLTDFGF + + +LS T+CGS AYA+PE
Sbjct: 123 VRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQA-HGYPDLSTTYCGSAAYASPE 181
Query: 180 VLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQ 239
VL GIP+D KK DVWSMGVVLYVM+ +PFDD+DI + +Q++GV +P L +S C+
Sbjct: 182 VLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCK 241
Query: 240 DLLKRLLEPDMILRPSIEEVSWHPWL 265
L+ LL+ RPS +V+ + WL
Sbjct: 242 ALIAELLQFSPSARPSAGQVARNCWL 267
>gi|42734401 testis-specific serine kinase 4 [Homo sapiens]
Length = 328
Score = 215 bits (547), Expect = 4e-56
Identities = 108/253 (42%), Positives = 165/253 (65%), Gaps = 16/253 (6%)
Query: 9 GYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHK 68
GY++GK IG G+Y V EAF K + VA+K+I K ++++ +FLPRE+Q+++ L HK
Sbjct: 24 GYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHK 83
Query: 69 NIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGC 128
+I Y +ES ++ +++ELA+GGDV + + G E A F Q+ I Y H
Sbjct: 84 YLINFYRAIESTS-RVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSK 142
Query: 129 GVAHRDLKCENALLQGF-NLKLTDFGFAKVLPK--------SHRE------LSQTFCGST 173
+ HRDLK EN LL + N+K++DFGFAK++P S+R+ LSQT+CGS
Sbjct: 143 SIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSF 202
Query: 174 AYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLS 233
AYA PE+L+G+P++ D WSMGV+LY ++ A LPFDDT++ K+L + QK V+FP + +
Sbjct: 203 AYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHT 262
Query: 234 ISADCQDLLKRLL 246
IS +C++L+ ++L
Sbjct: 263 ISQECKNLILQML 275
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 195 bits (495), Expect = 4e-50
Identities = 106/257 (41%), Positives = 166/257 (64%), Gaps = 6/257 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y+L KTIG+G ++KVK A R+VA+K+IDK +Q+ RE++I++ L+H N
Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 118
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
I++++E++E+ + + LVME A GG+VFD ++ G + E A+A FRQ+V A++YCH
Sbjct: 119 IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKY 177
Query: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
+ HRDLK EN LL G N+K+ DFGF+ ++ TFCGS YAAPE+ QG +D
Sbjct: 178 IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK--LDTFCGSPPYAAPELFQGKKYDG 235
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
+ DVWS+GV+LY ++ SLPFD ++ ++ + +G + +S DC++LLK+LL
Sbjct: 236 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKLLVL 294
Query: 249 DMILRPSIEEVSWHPWL 265
+ I R S+E++ W+
Sbjct: 295 NPIKRGSLEQIMKDRWM 311
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 188 bits (477), Expect = 5e-48
Identities = 103/257 (40%), Positives = 163/257 (63%), Gaps = 6/257 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y+L KTIG+G ++KVK A R+VAIK+IDK +Q+ RE++I++ L+H N
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
I++++E++E+ + + L+ME A GG+VFD ++ G + E A++ FRQ+V A++YCH
Sbjct: 115 IVKLFEVIET-EKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKR 173
Query: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
+ HRDLK EN LL N+K+ DFGF+ + TFCGS YAAPE+ QG +D
Sbjct: 174 IVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK--LDTFCGSPPYAAPELFQGKKYDG 231
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
+ DVWS+GV+LY ++ SLPFD ++ ++ + +G + +S DC++LLKR L
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKRFLVL 290
Query: 249 DMILRPSIEEVSWHPWL 265
+ I R ++E++ W+
Sbjct: 291 NPIKRGTLEQIMKDRWI 307
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 188 bits (477), Expect = 5e-48
Identities = 103/257 (40%), Positives = 163/257 (63%), Gaps = 6/257 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y+L KTIG+G ++KVK A R+VAIK+IDK +Q+ RE++I++ L+H N
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
I++++E++E+ + + L+ME A GG+VFD ++ G + E A++ FRQ+V A++YCH
Sbjct: 115 IVKLFEVIET-EKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKR 173
Query: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
+ HRDLK EN LL N+K+ DFGF+ + TFCGS YAAPE+ QG +D
Sbjct: 174 IVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK--LDTFCGSPPYAAPELFQGKKYDG 231
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
+ DVWS+GV+LY ++ SLPFD ++ ++ + +G + +S DC++LLKR L
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKRFLVL 290
Query: 249 DMILRPSIEEVSWHPWL 265
+ I R ++E++ W+
Sbjct: 291 NPIKRGTLEQIMKDRWI 307
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 188 bits (477), Expect = 5e-48
Identities = 103/257 (40%), Positives = 163/257 (63%), Gaps = 6/257 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y+L KTIG+G ++KVK A R+VAIK+IDK +Q+ RE++I++ L+H N
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
I++++E++E+ + + L+ME A GG+VFD ++ G + E A++ FRQ+V A++YCH
Sbjct: 115 IVKLFEVIET-EKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKR 173
Query: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
+ HRDLK EN LL N+K+ DFGF+ + TFCGS YAAPE+ QG +D
Sbjct: 174 IVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK--LDTFCGSPPYAAPELFQGKKYDG 231
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
+ DVWS+GV+LY ++ SLPFD ++ ++ + +G + +S DC++LLKR L
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKRFLVL 290
Query: 249 DMILRPSIEEVSWHPWL 265
+ I R ++E++ W+
Sbjct: 291 NPIKRGTLEQIMKDRWI 307
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 188 bits (477), Expect = 5e-48
Identities = 103/257 (40%), Positives = 163/257 (63%), Gaps = 6/257 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y+L KTIG+G ++KVK A R+VAIK+IDK +Q+ RE++I++ L+H N
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
I++++E++E+ + + L+ME A GG+VFD ++ G + E A++ FRQ+V A++YCH
Sbjct: 115 IVKLFEVIET-EKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKR 173
Query: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
+ HRDLK EN LL N+K+ DFGF+ + TFCGS YAAPE+ QG +D
Sbjct: 174 IVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK--LDTFCGSPPYAAPELFQGKKYDG 231
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
+ DVWS+GV+LY ++ SLPFD ++ ++ + +G + +S DC++LLKR L
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKRFLVL 290
Query: 249 DMILRPSIEEVSWHPWL 265
+ I R ++E++ W+
Sbjct: 291 NPIKRGTLEQIMKDRWI 307
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 187 bits (476), Expect = 6e-48
Identities = 100/257 (38%), Positives = 162/257 (63%), Gaps = 6/257 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y++ +TIG+G ++ VK A + KVAIK+IDK EE +++ RE+QI++ L H +
Sbjct: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPH 66
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
II++Y+++E+ + I LV E A GG++FD ++ G + E A+ F+Q+V A+ +CH
Sbjct: 67 IIRLYQVMET-ERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN 125
Query: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
+ HRDLK EN LL N+K+ DFGF+ + +L +T+CGS YAAPE+ +G +D
Sbjct: 126 IVHRDLKAENLLLDANLNIKIADFGFSNLFTPG--QLLKTWCGSPPYAAPELFEGKEYDG 183
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
K D+WS+GVVLYV++C +LPFD + + + + G F +S +C+ L++ +L
Sbjct: 184 PKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSG-KFRIPFFMSTECEHLIRHMLVL 242
Query: 249 DMILRPSIEEVSWHPWL 265
D R S+E++ H W+
Sbjct: 243 DPNKRLSMEQICKHKWM 259
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 186 bits (471), Expect = 2e-47
Identities = 101/257 (39%), Positives = 163/257 (63%), Gaps = 6/257 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y+L KTIG+G ++KVK A ++VA+K+IDK +Q+ RE++I++ L+H N
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
I++++E++E+ + + LVME A GG+VFD ++ G + E A+A FRQ+V A++YCH
Sbjct: 112 IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
Query: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
+ HRDLK EN LL N+K+ DFGF+ ++ TFCGS YAAPE+ QG +D
Sbjct: 171 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK--LDTFCGSPPYAAPELFQGKKYDG 228
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
+ DVWS+GV+LY ++ SLPFD ++ ++ + +G + +S DC++LLK+ L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKFLIL 287
Query: 249 DMILRPSIEEVSWHPWL 265
+ R ++E++ W+
Sbjct: 288 NPSKRGTLEQIMKDRWM 304
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 186 bits (471), Expect = 2e-47
Identities = 101/257 (39%), Positives = 163/257 (63%), Gaps = 6/257 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y+L KTIG+G ++KVK A ++VA+K+IDK +Q+ RE++I++ L+H N
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
I++++E++E+ + + LVME A GG+VFD ++ G + E A+A FRQ+V A++YCH
Sbjct: 112 IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
Query: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
+ HRDLK EN LL N+K+ DFGF+ ++ TFCGS YAAPE+ QG +D
Sbjct: 171 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK--LDTFCGSPPYAAPELFQGKKYDG 228
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
+ DVWS+GV+LY ++ SLPFD ++ ++ + +G + +S DC++LLK+ L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKFLIL 287
Query: 249 DMILRPSIEEVSWHPWL 265
+ R ++E++ W+
Sbjct: 288 NPSKRGTLEQIMKDRWM 304
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 186 bits (471), Expect = 2e-47
Identities = 101/257 (39%), Positives = 163/257 (63%), Gaps = 6/257 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y+L KTIG+G ++KVK A ++VA+K+IDK +Q+ RE++I++ L+H N
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
I++++E++E+ + + LVME A GG+VFD ++ G + E A+A FRQ+V A++YCH
Sbjct: 112 IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
Query: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
+ HRDLK EN LL N+K+ DFGF+ ++ TFCGS YAAPE+ QG +D
Sbjct: 171 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK--LDTFCGSPPYAAPELFQGKKYDG 228
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
+ DVWS+GV+LY ++ SLPFD ++ ++ + +G + +S DC++LLK+ L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKFLIL 287
Query: 249 DMILRPSIEEVSWHPWL 265
+ R ++E++ W+
Sbjct: 288 NPSKRGTLEQIMKDRWM 304
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 186 bits (471), Expect = 2e-47
Identities = 101/257 (39%), Positives = 163/257 (63%), Gaps = 6/257 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y+L KTIG+G ++KVK A ++VA+K+IDK +Q+ RE++I++ L+H N
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
I++++E++E+ + + LVME A GG+VFD ++ G + E A+A FRQ+V A++YCH
Sbjct: 112 IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
Query: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
+ HRDLK EN LL N+K+ DFGF+ ++ TFCGS YAAPE+ QG +D
Sbjct: 171 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK--LDTFCGSPPYAAPELFQGKKYDG 228
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
+ DVWS+GV+LY ++ SLPFD ++ ++ + +G + +S DC++LLK+ L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKFLIL 287
Query: 249 DMILRPSIEEVSWHPWL 265
+ R ++E++ W+
Sbjct: 288 NPSKRGTLEQIMKDRWM 304
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 186 bits (471), Expect = 2e-47
Identities = 101/257 (39%), Positives = 163/257 (63%), Gaps = 6/257 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y+L KTIG+G ++KVK A ++VA+K+IDK +Q+ RE++I++ L+H N
Sbjct: 20 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 78
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
I++++E++E+ + + LVME A GG+VFD ++ G + E A+A FRQ+V A++YCH
Sbjct: 79 IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 137
Query: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
+ HRDLK EN LL N+K+ DFGF+ ++ TFCGS YAAPE+ QG +D
Sbjct: 138 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK--LDTFCGSPPYAAPELFQGKKYDG 195
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
+ DVWS+GV+LY ++ SLPFD ++ ++ + +G + +S DC++LLK+ L
Sbjct: 196 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKFLIL 254
Query: 249 DMILRPSIEEVSWHPWL 265
+ R ++E++ W+
Sbjct: 255 NPSKRGTLEQIMKDRWM 271
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 185 bits (469), Expect = 4e-47
Identities = 100/257 (38%), Positives = 163/257 (63%), Gaps = 6/257 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y + +T+G+G ++ VK A + + +VAIK+IDK +++ RE+Q+++ L+H +
Sbjct: 27 YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIY-REVQLMKLLNHPH 85
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
II++Y+++E+ D + +V E A+ G++FD + + G L E+ A+ F Q++ A+ YCH
Sbjct: 86 IIKLYQVMETKD-MLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHH 144
Query: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
+ HRDLK EN LL G ++KL DFGF KS LS T+CGS YAAPEV +G ++
Sbjct: 145 IVHRDLKTENLLLDGNMDIKLADFGFGNFY-KSGEPLS-TWCGSPPYAAPEVFEGKEYEG 202
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
+ D+WS+GVVLYV++C SLPFD ++P + + +G F +S DC+ L++R+L
Sbjct: 203 PQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEG-RFRIPFFMSQDCESLIRRMLVV 261
Query: 249 DMILRPSIEEVSWHPWL 265
D R +I ++ H W+
Sbjct: 262 DPARRITIAQIRQHRWM 278
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 183 bits (465), Expect = 1e-46
Identities = 102/257 (39%), Positives = 157/257 (61%), Gaps = 6/257 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y + T+G+G ++ VK + + +VAIK+IDK +++ RE+QI++ LDH +
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIY-REVQIMKMLDHPH 78
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
II++Y+++E+ + LV E A+ G++FD + N G L ES A+ F Q++ A+ YCHG
Sbjct: 79 IIKLYQVMETKS-MLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRK 137
Query: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
+ HRDLK EN LL N+K+ DFGF EL T+CGS YAAPEV +G ++
Sbjct: 138 IVHRDLKAENLLLDNNMNIKIADFGFGNFFKSG--ELLATWCGSPPYAAPEVFEGQQYEG 195
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
+ D+WSMGVVLYV++C +LPFD +P +L Q+ F +S DC+ L++R+L
Sbjct: 196 PQLDIWSMGVVLYVLVCGALPFDGPTLP-ILRQRVLEGRFRIPYFMSEDCEHLIRRMLVL 254
Query: 249 DMILRPSIEEVSWHPWL 265
D R +I ++ H W+
Sbjct: 255 DPSKRLTIAQIKEHKWM 271
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 182 bits (463), Expect = 2e-46
Identities = 99/257 (38%), Positives = 160/257 (62%), Gaps = 6/257 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y+L +TIG+G ++KVK A R+VAIK+IDK +Q+ RE++I++ L+H N
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLF-REVRIMKGLNHPN 117
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
I++++E++E+ + + LVME A G+VFD +++ G + E A+A FRQ+V A+ YCH
Sbjct: 118 IVKLFEVIET-EKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKN 176
Query: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
+ HRDLK EN LL N+K+ DFGF+ + TFCGS YAAPE+ QG +D
Sbjct: 177 IVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSK--LDTFCGSPPYAAPELFQGKKYDG 234
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
+ D+WS+GV+LY ++ SLPFD ++ ++ + +G + +S DC+ +L+R L
Sbjct: 235 PEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRG-KYRVPFYMSTDCESILRRFLVL 293
Query: 249 DMILRPSIEEVSWHPWL 265
+ R ++E++ W+
Sbjct: 294 NPAKRCTLEQIMKDKWI 310
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 174 bits (440), Expect = 9e-44
Identities = 100/262 (38%), Positives = 155/262 (59%), Gaps = 8/262 (3%)
Query: 6 LSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTL 65
L + Y+L +T+G+GTY KVK A + R VAIK I K +E + RE++I+ +L
Sbjct: 51 LKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSL 110
Query: 66 DHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYC 125
+H +II +YE+ E+ D KI ++ME A G+++D + L E + FRQ+V A+ YC
Sbjct: 111 NHPHIISIYEVFENKD-KIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYC 169
Query: 126 HGCGVAHRDLKCENALL-QGFNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGI 184
H GV HRDLK EN LL N+K+ DFG + + K + QTFCGS YA+PE++ G
Sbjct: 170 HKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKD--KFLQTFCGSPLYASPEIVNGR 227
Query: 185 PHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKG-VSFPTHLSISADCQDLLK 243
P+ + D W++GV+LY ++ ++PFD D ++ Q G PT S D + L++
Sbjct: 228 PYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS---DARGLIR 284
Query: 244 RLLEPDMILRPSIEEVSWHPWL 265
+L + R +IE+++ H W+
Sbjct: 285 WMLMVNPDRRATIEDIANHWWV 306
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 172 bits (435), Expect = 4e-43
Identities = 105/262 (40%), Positives = 160/262 (61%), Gaps = 15/262 (5%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPR---ELQIVRTLD 66
Y+L +TIG G ++KVK A VAIK++DK + LPR E++ ++ L
Sbjct: 11 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDK-----NTLGSDLPRIKTEIEALKNLR 65
Query: 67 HKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCH 126
H++I Q+Y +LE+A+ KI +V+E GG++FD +++ L E + +FRQ+V A+ Y H
Sbjct: 66 HQHICQLYHVLETAN-KIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVH 124
Query: 127 GCGVAHRDLKCENALLQGFN-LKLTDFGFAKVLPKSHRELS-QTFCGSTAYAAPEVLQGI 184
G AHRDLK EN L ++ LKL DFG PK +++ QT CGS AYAAPE++QG
Sbjct: 125 SQGYAHRDLKPENLLFDEYHKLKLIDFGLC-AKPKGNKDYHLQTCCGSLAYAAPELIQGK 183
Query: 185 PHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKG-VSFPTHLSISADCQDLLK 243
+ + DVWSMG++LYV++C LPFDD ++ + + +G P LS S+ LL+
Sbjct: 184 SYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSIL--LLQ 241
Query: 244 RLLEPDMILRPSIEEVSWHPWL 265
++L+ D R S++ + HPW+
Sbjct: 242 QMLQVDPKKRISMKNLLNHPWI 263
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 171 bits (434), Expect = 5e-43
Identities = 91/256 (35%), Positives = 158/256 (61%), Gaps = 6/256 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y+L KT+G+G VK +KVAIK++++ E + + + RE+ I++ ++H +
Sbjct: 34 YRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMK-VEREIAILKLIEHPH 92
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
+++++++ E+ + LV+E GG++FD ++ G L A+ FRQ+V A+ +CH
Sbjct: 93 VLKLHDVYENKK-YLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYS 151
Query: 130 VAHRDLKCENALL-QGFNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
+ HRDLK EN LL + N+++ DFG A + + L +T CGS YA PEV++G +D
Sbjct: 152 ICHRDLKPENLLLDEKNNIRIADFGMASL--QVGDSLLETSCGSPHYACPEVIKGEKYDG 209
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
++ D+WS GV+L+ +L +LPFDD ++ ++L + ++GV H I DCQ LL+ ++E
Sbjct: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHF-IPPDCQSLLRGMIEV 268
Query: 249 DMILRPSIEEVSWHPW 264
+ R S+E++ HPW
Sbjct: 269 EPEKRLSLEQIQKHPW 284
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 170 bits (430), Expect = 1e-42
Identities = 94/256 (36%), Positives = 148/256 (57%), Gaps = 5/256 (1%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y LG T+G GT+ KVK + KVA+K++++ + + RE+Q ++ H +
Sbjct: 27 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 86
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
II++Y+++ S I +VME GG++FD + G L E ++ LF+Q++ + YCH
Sbjct: 87 IIKLYQVI-STPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 145
Query: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
V HRDLK EN LL N K+ DFG + ++ S E +T CGS YAAPEV+ G +
Sbjct: 146 VVHRDLKPENVLLDAHMNAKIADFGLSNMM--SDGEFLRTSCGSPNYAAPEVISGRLYAG 203
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
+ D+WS GV+LY +LC +LPFDD +P + + G+ F T ++ LLK +L+
Sbjct: 204 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI-FYTPQYLNPSVISLLKHMLQV 262
Query: 249 DMILRPSIEEVSWHPW 264
D + R +I+++ H W
Sbjct: 263 DPMKRATIKDIREHEW 278
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 170 bits (430), Expect = 1e-42
Identities = 91/256 (35%), Positives = 156/256 (60%), Gaps = 6/256 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y+L KT+G+G VK +KVAIK++++ E + + + RE+ I++ ++H +
Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMK-VEREIAILKLIEHPH 77
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
+++++++ E+ + LV+E GG++FD ++ G L A+ FRQ++ A+ +CH
Sbjct: 78 VLKLHDVYENKK-YLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHS 136
Query: 130 VAHRDLKCENALL-QGFNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
+ HRDLK EN LL + N+++ DFG A + + L +T CGS YA PEV++G +D
Sbjct: 137 ICHRDLKPENLLLDEKNNIRIADFGMASL--QVGDSLLETSCGSPHYACPEVIRGEKYDG 194
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
+K DVWS GV+L+ +L +LPFDD ++ ++L + ++GV H I DCQ LL+ ++E
Sbjct: 195 RKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHF-IPPDCQSLLRGMIEV 253
Query: 249 DMILRPSIEEVSWHPW 264
D R ++E + H W
Sbjct: 254 DAARRLTLEHIQKHIW 269
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 170 bits (430), Expect = 1e-42
Identities = 101/261 (38%), Positives = 154/261 (59%), Gaps = 12/261 (4%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y L KT+G G ++ VK A KVA+KVIDK + L +E++ ++ + H N
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTK-LDTLATGHLFQEVRCMKLVQHPN 74
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGP-LPESRAKALFRQMVEAIRYCHGC 128
I+++YE++++ K+ L++EL +GGD+FD ++ L E AK F Q+V AI YCH
Sbjct: 75 IVRLYEVIDTQT-KLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 129 GVAHRDLKCENALL---QGFNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIP 185
V HRDLK EN + QG +KLTDFGF+ + T CGS AY+APE+L G
Sbjct: 134 HVVHRDLKPENVVFFEKQGL-VKLTDFGFSNKFQPGKK--LTTSCGSLAYSAPEILLGDE 190
Query: 186 HDSKKGDVWSMGVVLYVMLCASLPFDD-TDIPKMLWQQQKGVSFPTHLSISADCQDLLKR 244
+D+ D+WS+GV+L++++C PF + D + + P+H +S +C+DL+ R
Sbjct: 191 YDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSH--VSKECKDLITR 248
Query: 245 LLEPDMILRPSIEEVSWHPWL 265
+L+ D R S+EE+ HPWL
Sbjct: 249 MLQRDPKRRASLEEIENHPWL 269
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 170 bits (430), Expect = 1e-42
Identities = 101/261 (38%), Positives = 154/261 (59%), Gaps = 12/261 (4%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y L KT+G G ++ VK A KVA+KVIDK + L +E++ ++ + H N
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTK-LDTLATGHLFQEVRCMKLVQHPN 74
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGP-LPESRAKALFRQMVEAIRYCHGC 128
I+++YE++++ K+ L++EL +GGD+FD ++ L E AK F Q+V AI YCH
Sbjct: 75 IVRLYEVIDTQT-KLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 129 GVAHRDLKCENALL---QGFNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIP 185
V HRDLK EN + QG +KLTDFGF+ + T CGS AY+APE+L G
Sbjct: 134 HVVHRDLKPENVVFFEKQGL-VKLTDFGFSNKFQPGKK--LTTSCGSLAYSAPEILLGDE 190
Query: 186 HDSKKGDVWSMGVVLYVMLCASLPFDD-TDIPKMLWQQQKGVSFPTHLSISADCQDLLKR 244
+D+ D+WS+GV+L++++C PF + D + + P+H +S +C+DL+ R
Sbjct: 191 YDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSH--VSKECKDLITR 248
Query: 245 LLEPDMILRPSIEEVSWHPWL 265
+L+ D R S+EE+ HPWL
Sbjct: 249 MLQRDPKRRASLEEIENHPWL 269
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 168 bits (425), Expect = 5e-42
Identities = 95/257 (36%), Positives = 150/257 (58%), Gaps = 7/257 (2%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y LG T+G GT+ KVK + KVA+K++++ + + RE+Q ++ H +
Sbjct: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
II++Y+++ S +VME GG++FD + G + E A+ LF+Q++ A+ YCH
Sbjct: 76 IIKLYQVI-STPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134
Query: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
V HRDLK EN LL N K+ DFG + ++ S E +T CGS YAAPEV+ G +
Sbjct: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMM--SDGEFLRTSCGSPNYAAPEVISGRLYAG 192
Query: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSF-PTHLSISADCQDLLKRLLE 247
+ D+WS GV+LY +LC +LPFDD +P + + + GV + P +L+ S LL +L+
Sbjct: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV--ATLLMHMLQ 250
Query: 248 PDMILRPSIEEVSWHPW 264
D + R +I+++ H W
Sbjct: 251 VDPLKRATIKDIREHEW 267
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 162 bits (410), Expect = 3e-40
Identities = 99/261 (37%), Positives = 156/261 (59%), Gaps = 7/261 (2%)
Query: 6 LSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTL 65
L + Y+ +T+G+GTY KVK+A + R VAIK I K +E + RE++I+ +L
Sbjct: 49 LRHRYEFLETLGKGTYGKVKKA-RESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSL 107
Query: 66 DHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYC 125
+H +II ++E+ E++ KI +VME A GD++D + L E A+ FRQ+V A+ YC
Sbjct: 108 NHPHIIAIHEVFENSS-KIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYC 166
Query: 126 HGCGVAHRDLKCENALLQ-GFNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGI 184
H V HRDLK EN LL N+K+ DFG + + + + QTFCGS YA+PE++ G
Sbjct: 167 HQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQG--KFLQTFCGSPLYASPEIVNGK 224
Query: 185 PHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKR 244
P+ + D WS+GV+LY+++ ++PFD D K+L +Q ++ S C L++
Sbjct: 225 PYTGPEVDSWSLGVLLYILVHGTMPFDGHD-HKILVKQISNGAYREPPKPSDAC-GLIRW 282
Query: 245 LLEPDMILRPSIEEVSWHPWL 265
LL + R ++E+V+ H W+
Sbjct: 283 LLMVNPTRRATLEDVASHWWV 303
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 160 bits (405), Expect = 1e-39
Identities = 94/271 (34%), Positives = 148/271 (54%), Gaps = 20/271 (7%)
Query: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Y LG T+G GT+ KVK + KVA+K++++ + + RE+Q ++ H +
Sbjct: 27 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 86
Query: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGG---------------PLPESRAKAL 114
II++Y+++ S I +VME GG++FD + G L E ++ L
Sbjct: 87 IIKLYQVI-STPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRL 145
Query: 115 FRQMVEAIRYCHGCGVAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGST 173
F+Q++ + YCH V HRDLK EN LL N K+ DFG + ++ S E +T CGS
Sbjct: 146 FQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM--SDGEFLRTSCGSP 203
Query: 174 AYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLS 233
YAAPEV+ G + + D+WS GV+LY +LC +LPFDD +P + + G+ F T
Sbjct: 204 NYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI-FYTPQY 262
Query: 234 ISADCQDLLKRLLEPDMILRPSIEEVSWHPW 264
++ LLK +L+ D + R +I+++ H W
Sbjct: 263 LNPSVISLLKHMLQVDPMKRATIKDIREHEW 293
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 150 bits (378), Expect = 1e-36
Identities = 99/262 (37%), Positives = 146/262 (55%), Gaps = 8/262 (3%)
Query: 10 YQLG-KTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEE-FIQRFLPRELQIVRTLDH 67
Y +G + +GEG+++KV+E KVAIKVIDK ++ ++ + L RE QI + + H
Sbjct: 61 YLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRH 120
Query: 68 KNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHG 127
NI Q+ ++LE+ + LVMEL GG++ + L ES A+ RQ++ A+ + H
Sbjct: 121 PNITQLLDILET-ENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHR 179
Query: 128 CGVAHRDLKCENALL-QGFNLKLTDFGFAKVLP-KSHRELSQTFCGSTAYAAPEVLQGIP 185
GV HRDLK EN LL + N+KL DFG + + + T CGS AYAAPE+L
Sbjct: 180 AGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKK 239
Query: 186 HDSKKGDVWSMGVVLYVMLCASLPFDDTDIP-KMLWQQQKGVSF-PTHLSISADCQDLLK 243
+ K DVWS+GV +Y ML +LPF + L+Q+ P +S L+
Sbjct: 240 Y-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLR 298
Query: 244 RLLEPDMILRPSIEEVSWHPWL 265
LLEPD + RP+I++ + WL
Sbjct: 299 SLLEPDPVKRPNIQQALANRWL 320
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,586,092
Number of Sequences: 37866
Number of extensions: 453833
Number of successful extensions: 3266
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 480
Number of HSP's successfully gapped in prelim test: 278
Number of HSP's that attempted gapping in prelim test: 1152
Number of HSP's gapped (non-prelim): 879
length of query: 268
length of database: 18,247,518
effective HSP length: 100
effective length of query: 168
effective length of database: 14,460,918
effective search space: 2429434224
effective search space used: 2429434224
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.