Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 163644311
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
(1001 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 2026 0.0
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 2026 0.0
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 1374 0.0
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 1374 0.0
gi|14249340 phospholipase C, delta 4 [Homo sapiens] 509 e-144
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 484 e-136
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 484 e-136
gi|19115964 phospholipase C delta 3 [Homo sapiens] 452 e-127
gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 441 e-123
gi|78499633 phospholipase C, eta 2 [Homo sapiens] 380 e-105
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 344 3e-94
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 344 3e-94
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 340 3e-93
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 336 7e-92
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 336 7e-92
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 326 8e-89
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 326 8e-89
gi|95147333 phospholipase C, beta 2 [Homo sapiens] 305 2e-82
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 218 3e-56
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 218 3e-56
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 213 9e-55
gi|11386139 phospholipase C beta 3 [Homo sapiens] 181 3e-45
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 170 5e-42
gi|23943920 cytosolic phospholipase A2, group IVA [Homo sapiens] 44 8e-04
gi|61742814 coiled-coil and C2 domain containing 1B [Homo sapiens] 42 0.004
gi|21361472 neural precursor cell expressed, developmentally dow... 41 0.006
gi|222352090 neural precursor cell expressed, developmentally do... 41 0.006
gi|222352088 neural precursor cell expressed, developmentally do... 41 0.006
gi|222352086 neural precursor cell expressed, developmentally do... 41 0.006
gi|238550198 synaptotagmin III [Homo sapiens] 37 0.071
>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
Length = 1127
Score = 2026 bits (5248), Expect = 0.0
Identities = 1001/1001 (100%), Positives = 1001/1001 (100%)
Query: 1 MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 60
MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI
Sbjct: 127 MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 186
Query: 61 DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 120
DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL
Sbjct: 187 DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 246
Query: 121 RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 180
RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS
Sbjct: 247 RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 306
Query: 181 KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 240
KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF
Sbjct: 307 KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 366
Query: 241 LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 300
LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ
Sbjct: 367 LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 426
Query: 301 DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 360
DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT
Sbjct: 427 DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 486
Query: 361 GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT 420
GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT
Sbjct: 487 GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT 546
Query: 421 SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN 480
SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN
Sbjct: 547 SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN 606
Query: 481 VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVN 540
VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVN
Sbjct: 607 VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVN 666
Query: 541 YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY 600
YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY
Sbjct: 667 YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY 726
Query: 601 VLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE 660
VLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE
Sbjct: 727 VLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE 786
Query: 661 IHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT 720
IHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT
Sbjct: 787 IHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT 846
Query: 721 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA 780
IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA
Sbjct: 847 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA 906
Query: 781 SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR 840
SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR
Sbjct: 907 SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR 966
Query: 841 FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIV 900
FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIV
Sbjct: 967 FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIV 1026
Query: 901 HCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLK 960
HCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLK
Sbjct: 1027 HCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLK 1086
Query: 961 QIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE 1001
QIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE
Sbjct: 1087 QIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE 1127
>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
Length = 1001
Score = 2026 bits (5248), Expect = 0.0
Identities = 1001/1001 (100%), Positives = 1001/1001 (100%)
Query: 1 MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 60
MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI
Sbjct: 1 MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 60
Query: 61 DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 120
DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL
Sbjct: 61 DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 120
Query: 121 RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 180
RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS
Sbjct: 121 RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 180
Query: 181 KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 240
KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF
Sbjct: 181 KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 240
Query: 241 LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 300
LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ
Sbjct: 241 LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 300
Query: 301 DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 360
DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT
Sbjct: 301 DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 360
Query: 361 GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT 420
GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT
Sbjct: 361 GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT 420
Query: 421 SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN 480
SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN
Sbjct: 421 SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN 480
Query: 481 VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVN 540
VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVN
Sbjct: 481 VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVN 540
Query: 541 YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY 600
YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY
Sbjct: 541 YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY 600
Query: 601 VLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE 660
VLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE
Sbjct: 601 VLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE 660
Query: 661 IHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT 720
IHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT
Sbjct: 661 IHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT 720
Query: 721 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA 780
IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA
Sbjct: 721 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA 780
Query: 781 SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR 840
SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR
Sbjct: 781 SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR 840
Query: 841 FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIV 900
FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIV
Sbjct: 841 FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIV 900
Query: 901 HCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLK 960
HCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLK
Sbjct: 901 HCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLK 960
Query: 961 QIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE 1001
QIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE
Sbjct: 961 QIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE 1001
>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
Length = 1095
Score = 1374 bits (3556), Expect = 0.0
Identities = 667/999 (66%), Positives = 807/999 (80%), Gaps = 8/999 (0%)
Query: 1 MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 60
MP+EKKISSA+DCI+ M G ELKKVR NSRIY+R+F LD D+Q+LRWEPSKKD EKAK+
Sbjct: 99 MPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKL 158
Query: 61 DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 120
DI +IKE+R GKNT+ FR+NG++DQI EDCAFS+++GENYESLDLVANSADVANIWV+GL
Sbjct: 159 DISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGL 218
Query: 121 RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 180
RYL+S K LD +E +Q+ R W+ +F DVD G + +V+ I+ LNP LK +
Sbjct: 219 RYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEA 278
Query: 181 KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 240
KI LKFKE+ KSK+K T VT+EEF E F ELCTRPE+YFLLVQ S NKE+LD DLM+F
Sbjct: 279 KIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLF 338
Query: 241 LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 300
LEAEQGV HI E+I L+II +YE S+EG++KG+L+IDGFT YL+S +C IFDPE KKV Q
Sbjct: 339 LEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQ 398
Query: 301 DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 360
DM QPLSHY+IN+SHNTYLIEDQFRGP+DI GYIRALKMGCRSVELDV DG DNEP++
Sbjct: 399 DMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCN 458
Query: 361 GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT 420
+ MT+ + FRSVI++INK+AF ASEYPLILCL NHCS+ QQKVM Q MKK+ G+KLYT
Sbjct: 459 RNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTE 518
Query: 421 SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKE-NMEQPN 479
+P ESYLPSP+ LK I++K KKL S+ +EG+VTDEDE AEMS+RM + N EQ
Sbjct: 519 APLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQ-- 576
Query: 480 NVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFV 539
K+ +LC+ELS+LVSICKSVQ+++F++S + Q YWE+CSF+E AS+ ANE P DFV
Sbjct: 577 ----KQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFV 632
Query: 540 NYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCG 599
NYNK+FL+R++PS MRIDSSN+NPQDFW CGCQIVAMNFQTPG MMDL+ GWF QNG CG
Sbjct: 633 NYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCG 692
Query: 600 YVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 659
YVLRP+IMR+EVS+FSANTK +PGVSP LHIKIISGQNFPKPKG+ AKGDV+DPYV +
Sbjct: 693 YVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCI 752
Query: 660 EIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQY 719
EIHGIPADC+EQRTKTV QN D PIFDE+FEFQ+NLPELAM+RFVVLDDDYIGDEFIGQY
Sbjct: 753 EIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQY 812
Query: 720 TIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREY 779
TIPFECLQ GYRHVPL+S G+++ H +LFVH+AITNR GGGK KR LSVR GKK REY
Sbjct: 813 TIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREY 872
Query: 780 ASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSP 839
LR + +KT+D++FK A P+R+A D+RENMQNA+VS KELCGL +A+L QC+L +S
Sbjct: 873 TMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSS 932
Query: 840 RFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKI 899
R + DNTP V L + + +P +E G +P+V KK++T YD+MIQ + LIE AD V EKI
Sbjct: 933 RLITSDNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKI 992
Query: 900 VHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENL 959
V CQKA MEFHE LH++G KEGLK RKL KA ESF WNIT+LKGQ DLLK AKNE +EN+
Sbjct: 993 VQCQKAGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENM 1052
Query: 960 KQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDE 998
KQI A +SCGL+K + +A+ K +RSLE I EK + E
Sbjct: 1053 KQIQLACLSCGLSKAPSSSAEA-KSKRSLEAIEEKESSE 1090
>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
Length = 997
Score = 1374 bits (3556), Expect = 0.0
Identities = 667/999 (66%), Positives = 807/999 (80%), Gaps = 8/999 (0%)
Query: 1 MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 60
MP+EKKISSA+DCI+ M G ELKKVR NSRIY+R+F LD D+Q+LRWEPSKKD EKAK+
Sbjct: 1 MPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKL 60
Query: 61 DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 120
DI +IKE+R GKNT+ FR+NG++DQI EDCAFS+++GENYESLDLVANSADVANIWV+GL
Sbjct: 61 DISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGL 120
Query: 121 RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 180
RYL+S K LD +E +Q+ R W+ +F DVD G + +V+ I+ LNP LK +
Sbjct: 121 RYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEA 180
Query: 181 KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 240
KI LKFKE+ KSK+K T VT+EEF E F ELCTRPE+YFLLVQ S NKE+LD DLM+F
Sbjct: 181 KIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLF 240
Query: 241 LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 300
LEAEQGV HI E+I L+II +YE S+EG++KG+L+IDGFT YL+S +C IFDPE KKV Q
Sbjct: 241 LEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQ 300
Query: 301 DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 360
DM QPLSHY+IN+SHNTYLIEDQFRGP+DI GYIRALKMGCRSVELDV DG DNEP++
Sbjct: 301 DMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCN 360
Query: 361 GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT 420
+ MT+ + FRSVI++INK+AF ASEYPLILCL NHCS+ QQKVM Q MKK+ G+KLYT
Sbjct: 361 RNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTE 420
Query: 421 SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKE-NMEQPN 479
+P ESYLPSP+ LK I++K KKL S+ +EG+VTDEDE AEMS+RM + N EQ
Sbjct: 421 APLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQ-- 478
Query: 480 NVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFV 539
K+ +LC+ELS+LVSICKSVQ+++F++S + Q YWE+CSF+E AS+ ANE P DFV
Sbjct: 479 ----KQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFV 534
Query: 540 NYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCG 599
NYNK+FL+R++PS MRIDSSN+NPQDFW CGCQIVAMNFQTPG MMDL+ GWF QNG CG
Sbjct: 535 NYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCG 594
Query: 600 YVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 659
YVLRP+IMR+EVS+FSANTK +PGVSP LHIKIISGQNFPKPKG+ AKGDV+DPYV +
Sbjct: 595 YVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCI 654
Query: 660 EIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQY 719
EIHGIPADC+EQRTKTV QN D PIFDE+FEFQ+NLPELAM+RFVVLDDDYIGDEFIGQY
Sbjct: 655 EIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQY 714
Query: 720 TIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREY 779
TIPFECLQ GYRHVPL+S G+++ H +LFVH+AITNR GGGK KR LSVR GKK REY
Sbjct: 715 TIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREY 774
Query: 780 ASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSP 839
LR + +KT+D++FK A P+R+A D+RENMQNA+VS KELCGL +A+L QC+L +S
Sbjct: 775 TMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSS 834
Query: 840 RFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKI 899
R + DNTP V L + + +P +E G +P+V KK++T YD+MIQ + LIE AD V EKI
Sbjct: 835 RLITSDNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKI 894
Query: 900 VHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENL 959
V CQKA MEFHE LH++G KEGLK RKL KA ESF WNIT+LKGQ DLLK AKNE +EN+
Sbjct: 895 VQCQKAGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENM 954
Query: 960 KQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDE 998
KQI A +SCGL+K + +A+ K +RSLE I EK + E
Sbjct: 955 KQIQLACLSCGLSKAPSSSAEA-KSKRSLEAIEEKESSE 992
>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
Length = 762
Score = 509 bits (1312), Expect = e-144
Identities = 294/756 (38%), Positives = 436/756 (57%), Gaps = 38/756 (5%)
Query: 17 MVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDI 76
M EG ++KVRS S RYF L D ++ + S K I ++ +R G ++++
Sbjct: 18 MQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSEL 77
Query: 77 FRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 136
RS +++++ + F++++ +LDL+ANS + A IW+ GL+ L+ D++ S
Sbjct: 78 LRS--LAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLV-------DLVTS 128
Query: 137 SQDNMRTS-WVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDK 195
R W+S F D + G ++ + + +N + E F +
Sbjct: 129 MDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQ---EYAFSLFQAADTS 185
Query: 196 AGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEIS 255
+ EEF++ + L R E+ L FS++ + L + + FL+ EQ E++
Sbjct: 186 QSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELA 245
Query: 256 LEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSH 315
LE+I +YEPS G+ + LS+DGF +YL S D IF+P + QDM QPL+HYFI SSH
Sbjct: 246 LELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSH 305
Query: 316 NTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVID 375
NTYL+ DQ G S + GYIRALK GCR VE+DVWDGP EPV+Y GHT+TS+I+F+ V+
Sbjct: 306 NTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVA 365
Query: 376 IINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLY-TTSPNVEESYLPSPDV 434
+ +YAF S+YP+IL LE HCS +QQ+ M +H+ ++LG++L TT V + LPSP+
Sbjct: 366 TVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEE 425
Query: 435 LKGKILIKAKKLSSNCSGVEGDVTDEDEGA---------------EMSQRMGKENMEQPN 479
L+ KIL+K KKL+ +E D+ E+E A E ++N++ +
Sbjct: 426 LRRKILVKGKKLT-----LEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKD 480
Query: 480 NVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFV 539
+ LC LS LV KSV F+ F S + ++E+ SF+E A + E +FV
Sbjct: 481 KKKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFV 540
Query: 540 NYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCG 599
+N L+RV+PS +R DSSN NPQ+ W GCQ+VAMN QT GL MD+ G FRQNG CG
Sbjct: 541 QHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCG 600
Query: 600 YVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 659
YVL+P +R+ S F + + + Q L I++ISGQ PK + +G +VDP V V
Sbjct: 601 YVLKPDFLRDIQSSF--HPEKPISPFKAQTLLIQVISGQQLPKVDKT-KEGSIVDPLVKV 657
Query: 660 EIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQ 718
+I G+ D A Q T V NG P + ++ F++ +PELAM+RFVV+D D+ ++FIGQ
Sbjct: 658 QIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQ 717
Query: 719 YTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 754
YT+P+ C+Q GYRH+ L S G L AS+FV++ I
Sbjct: 718 YTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYICI 753
>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
Length = 756
Score = 484 bits (1247), Expect = e-136
Identities = 287/753 (38%), Positives = 431/753 (57%), Gaps = 29/753 (3%)
Query: 14 INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 70
+ ++++GS+L KV+S+S R++ L D +++ W+ S+K E I+ I+EVR
Sbjct: 19 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 77
Query: 71 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 130
G T+ + + ED FS+++ + +LDL+A S A WV GL +I + +
Sbjct: 78 GHRTEGLEK--FARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSG-S 134
Query: 131 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 190
+D + Q W+ + D + ++ ++ LN + S F+E
Sbjct: 135 MDQRQKLQH-----WIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFREC- 188
Query: 191 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 249
D + T+ ++E IE F+++ T R EI + + + E L L+ FL+ +Q
Sbjct: 189 ---DHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEA 245
Query: 250 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 309
++L +I +YEPS+ + + ++ DGF YL+S D F H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHY 305
Query: 310 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 369
++SSHNTYL+EDQ GPS YIRAL GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365
Query: 370 FRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYL 429
F V+ I YAF AS YP+IL LENHC+++QQ+VM +H+ +LG L + + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSL 425
Query: 430 PSPDVLKGKILIKAKKLSSNC-SGVEGD-----VTDEDEGAEMSQRMGKENMEQPNNVPV 483
PSP+ LKGKIL+K KKL G EG V+DEDE AEM + ++ +
Sbjct: 426 PSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQ--HKPKE 483
Query: 484 KRFQLCKELSELVSICKSVQFKEF-QVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYN 542
+ +L +ELS++V CKSV F F Q ++E+ SF+E A + E+ FV +N
Sbjct: 484 DKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHN 543
Query: 543 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 602
L+R++P+ R DSSN +P + W GCQIVA+NFQTPG MD+ G F+ NG CGYVL
Sbjct: 544 VGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVL 603
Query: 603 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 662
+PA +R+ F+ P + + L+I++ISGQ PK + K +VDP V VEIH
Sbjct: 604 KPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKN--KNSIVDPKVTVEIH 661
Query: 663 GIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTI 721
G+ D A ++T + NG P +D F F++ +P+LA++RF+V D D ++FIGQ TI
Sbjct: 662 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 721
Query: 722 PFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 754
P L+ GYRHV L S G+ A+LFV +++
Sbjct: 722 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISL 754
>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
Length = 777
Score = 484 bits (1247), Expect = e-136
Identities = 287/753 (38%), Positives = 431/753 (57%), Gaps = 29/753 (3%)
Query: 14 INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 70
+ ++++GS+L KV+S+S R++ L D +++ W+ S+K E I+ I+EVR
Sbjct: 40 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 98
Query: 71 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 130
G T+ + + ED FS+++ + +LDL+A S A WV GL +I + +
Sbjct: 99 GHRTEGLEK--FARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSG-S 155
Query: 131 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 190
+D + Q W+ + D + ++ ++ LN + S F+E
Sbjct: 156 MDQRQKLQH-----WIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFREC- 209
Query: 191 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 249
D + T+ ++E IE F+++ T R EI + + + E L L+ FL+ +Q
Sbjct: 210 ---DHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEA 266
Query: 250 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 309
++L +I +YEPS+ + + ++ DGF YL+S D F H++V QDM QPLSHY
Sbjct: 267 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHY 326
Query: 310 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 369
++SSHNTYL+EDQ GPS YIRAL GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 327 LVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 386
Query: 370 FRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYL 429
F V+ I YAF AS YP+IL LENHC+++QQ+VM +H+ +LG L + + L
Sbjct: 387 FCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSL 446
Query: 430 PSPDVLKGKILIKAKKLSSNC-SGVEGD-----VTDEDEGAEMSQRMGKENMEQPNNVPV 483
PSP+ LKGKIL+K KKL G EG V+DEDE AEM + ++ +
Sbjct: 447 PSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQ--HKPKE 504
Query: 484 KRFQLCKELSELVSICKSVQFKEF-QVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYN 542
+ +L +ELS++V CKSV F F Q ++E+ SF+E A + E+ FV +N
Sbjct: 505 DKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHN 564
Query: 543 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 602
L+R++P+ R DSSN +P + W GCQIVA+NFQTPG MD+ G F+ NG CGYVL
Sbjct: 565 VGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVL 624
Query: 603 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 662
+PA +R+ F+ P + + L+I++ISGQ PK + K +VDP V VEIH
Sbjct: 625 KPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKN--KNSIVDPKVTVEIH 682
Query: 663 GIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTI 721
G+ D A ++T + NG P +D F F++ +P+LA++RF+V D D ++FIGQ TI
Sbjct: 683 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 742
Query: 722 PFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 754
P L+ GYRHV L S G+ A+LFV +++
Sbjct: 743 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISL 775
>gi|19115964 phospholipase C delta 3 [Homo sapiens]
Length = 789
Score = 452 bits (1163), Expect = e-127
Identities = 279/750 (37%), Positives = 408/750 (54%), Gaps = 34/750 (4%)
Query: 14 INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKID-IKSIKEVRTGK 72
+ +M+ GS L+K+RS + R + L D S+ ++ + I ++ I+ VR G
Sbjct: 62 VRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGH 121
Query: 73 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 132
++ R G + ++ + ++LDL A +A+ A WV GL L + LD
Sbjct: 122 QSEGLRRFG--GAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKL----RARLD 175
Query: 133 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKEL-HK 191
+ SQ W+ D + ++ +R +N + L FKE H
Sbjct: 176 AM--SQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHS 233
Query: 192 SKDKA-GTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHI 250
+ D+ G E+ EEF+ L RPE+ + Q+S L +L+ FLE +QG
Sbjct: 234 NNDRLEGAEI--EEFLR---RLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGA 287
Query: 251 NEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYF 310
+ ++I YE ++ ++ +++DGF YL+SP+ D H V QDM QPL+HYF
Sbjct: 288 TLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYF 347
Query: 311 INSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVF 370
I+SSHNTYL + Q GPS Y+RA GCR VELD W+GP EPVIY GHT+TS+I+F
Sbjct: 348 ISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILF 407
Query: 371 RSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYT---TSPNVEES 427
R V+ + +AF S YP+IL LENHC ++QQ M +H+ +LGD L T SPN EE
Sbjct: 408 RDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEE- 466
Query: 428 YLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRF- 486
LPSP+ LKG++L+K KKL + S ++D +E E + E E+ +R
Sbjct: 467 -LPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDE----EEEEEVEAAAQRRLA 521
Query: 487 -QLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRF 545
Q+ ELS L C + + + + + +V S +E A K E FV +N R
Sbjct: 522 KQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQ 581
Query: 546 LARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPA 605
L RV+P +R++S+N +PQ+ W GCQ+VA+NFQTPG MDLN G F NG CGYVL+PA
Sbjct: 582 LTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPA 641
Query: 606 IMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIP 665
+R+ S F PG L I++++ Q PK + +VDP V +EIHG+P
Sbjct: 642 CLRQPDSTFD----PEYPGPPRTTLSIQVLTAQQLPK-LNAEKPHSIVDPLVRIEIHGVP 696
Query: 666 ADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPFE 724
ADCA Q T V NG P + ++ +FQ+ PELA+VRFVV D D ++F+GQ+T+P
Sbjct: 697 ADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLS 756
Query: 725 CLQTGYRHVPLQSLTGEVLAHASLFVHVAI 754
L+ GYRH+ L S G L+ A+LF+ + I
Sbjct: 757 SLKQGYRHIHLLSKDGASLSPATLFIQIRI 786
>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
Length = 608
Score = 441 bits (1134), Expect = e-123
Identities = 238/576 (41%), Positives = 354/576 (61%), Gaps = 22/576 (3%)
Query: 187 KELHKSKDKAGT-EVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQ 245
K++ K D+ +T EEF ++ + R EI + +S N++ L +L FL EQ
Sbjct: 41 KQIFKDNDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRKILLASNLAQFLTQEQ 100
Query: 246 GVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQP 305
A +++ I+ EII KYEP +E ++ +S++GFT Y+ S +C +F E +KV QDM P
Sbjct: 101 YAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHP 160
Query: 306 LSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMT 365
L+ YFI+SSHNTYL+ DQ GPSD+ GY+ AL GCR +E+D WDG NEPV+Y G+T+T
Sbjct: 161 LNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLT 220
Query: 366 SQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVE 425
S+++F++VI I+KYAF S+YP++L LENHCS QQ+VM +++ G+ L + +
Sbjct: 221 SKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDF 280
Query: 426 ESYLPSPDVLKGKILIKAKKLSS-------NCSGVEGDVTDEDEGAEMSQRMGKENMEQP 478
LPSP+ LK KIL+K KK+ + S GD D++ G + + ++
Sbjct: 281 PDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKK- 339
Query: 479 NNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDF 538
++ ++ LS+LV K+ +FK FQ S Q++ E S E A K + +F
Sbjct: 340 ----TRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEF 395
Query: 539 VNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNC 598
+ + ++F+ R++P R DSSN NPQ+FW GCQ+VA+NFQTPGL MDL G F NG
Sbjct: 396 IFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGS 455
Query: 599 GYVLRPAIMREEVSFFS-ANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYV 657
GY+L+P +RE S+F+ +N K+ + P L I++ISG P S KGD + V
Sbjct: 456 GYILKPHFLRESKSYFNPSNIKEGM----PITLTIRLISGIQLPLTHSSSNKGDSL---V 508
Query: 658 YVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYI-GDEFI 716
+E+ G+P D +Q+T+ + +N +P ++E+F F I++PELA++RFVV I G+EF+
Sbjct: 509 IIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFIIHVPELALIRFVVEGQGLIAGNEFL 568
Query: 717 GQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHV 752
GQYT+P C+ GYR +PL S GE L ASLFV+V
Sbjct: 569 GQYTLPLLCMNKGYRRIPLFSRMGESLEPASLFVYV 604
>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
Length = 1416
Score = 380 bits (976), Expect = e-105
Identities = 204/457 (44%), Positives = 291/457 (63%), Gaps = 9/457 (1%)
Query: 13 CINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGK 72
C+ +M EG ++ K+R S+ R++ LD +RW PS+K+ EKAKI I SI+EV G+
Sbjct: 45 CMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKN-EKAKISIDSIQEVSEGR 103
Query: 73 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 132
+++F+ +C FS+ +G + ESLDLV+ S++VA WVTGLRYL++ G D
Sbjct: 104 QSEVFQRYP-DGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMA-GISDED 161
Query: 133 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKS 192
L Q R W+ Q F E D + G +++ +Q + LN L +++ F+E +
Sbjct: 162 SLARRQ-RTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREAD-T 219
Query: 193 KDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINE 252
D GT + EEF + + TR ++Y L++ +S++K+ LD L FL+ EQ +A +
Sbjct: 220 DDHQGT-LGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTL 278
Query: 253 EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFIN 312
E +II ++EP E + KG L IDGFTNY SP IF+PEH V QDM QPLSHYFI
Sbjct: 279 ESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFIT 338
Query: 313 SSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRS 372
SSHNTYL+ DQ S + Y L+ GCR VE+D WDGPD EP+++ G+T+TS+I+F+
Sbjct: 339 SSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKD 398
Query: 373 VIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPS 431
VI+ INKYAF +EYP+IL +ENHCS+ QQK M Q++ +LGDKL +S + E+ + LPS
Sbjct: 399 VIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPS 458
Query: 432 PDVLKGKILIKAKKLSSNCS--GVEGDVTDEDEGAEM 466
P +LKGKIL+K KKL +N S EG+V+DED E+
Sbjct: 459 PQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEI 495
Score = 241 bits (616), Expect = 2e-63
Identities = 129/320 (40%), Positives = 193/320 (60%), Gaps = 21/320 (6%)
Query: 442 KAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKS 501
K KL S EGD + G Q G + K +L + LS+LV KS
Sbjct: 586 KGSKLKKAASVEEGDEGQDSPGG---QSRGATRQK-------KTMKLSRALSDLVKYTKS 635
Query: 502 VQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNM 561
V + ++ + W+V SF+E A + + P ++ +N++ L+R++PS R+DSSN
Sbjct: 636 VATHDIEM--EAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNY 693
Query: 562 NPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDS 621
NPQ FW GCQ+VA+N+Q+ G M+ LN F NG CGYVL+P M + V F+ N++D
Sbjct: 694 NPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGV--FNPNSEDP 751
Query: 622 VPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQN 679
+PG + L ++IISGQ PKP+ S G +G+++DP+V VEI G+P DC+ ++T+ V N
Sbjct: 752 LPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDN 811
Query: 680 GDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLT 739
G P ++E+ F +++PE+A+VRF+V D D IG +FIGQ T+ F + GYRHV L
Sbjct: 812 GFNPTWEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYL---- 867
Query: 740 GEVLAHASLFVHVAITNRRG 759
E + AS+FVHVA+++ G
Sbjct: 868 -EGMEEASIFVHVAVSDISG 886
>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
Length = 1002
Score = 344 bits (882), Expect = 3e-94
Identities = 189/457 (41%), Positives = 279/457 (61%), Gaps = 9/457 (1%)
Query: 13 CINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGK 72
C++ M G+++ K++ ++ R F LD LRW PS+K SEKAKI I SI +V G+
Sbjct: 18 CMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK-SEKAKILIDSIYKVTEGR 76
Query: 73 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 132
++IF C F++ +G + ESLDL+ ++ + A W+TGL+YL++ G D
Sbjct: 77 QSEIFHRQA-EGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMA-GISDED 134
Query: 133 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKS 192
L Q WV Q F E D + G + + Q + LN L K+ F+E
Sbjct: 135 SLAKRQ-RTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTD 193
Query: 193 KDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINE 252
+++ GT +T EEF + + R ++Y LL+ +S K+ L ++L FL+ EQ + ++
Sbjct: 194 ENQ-GT-LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTT 251
Query: 253 EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFIN 312
+ L+II K+E S+E + K L I+GFTN++ SP C IF+P H +V QDM QPL +Y+I
Sbjct: 252 DYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIA 311
Query: 313 SSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRS 372
SSHNTYL DQ S + Y R L+ GCR VE+D WDGPD EPV++ G+T+TS+I+FR
Sbjct: 312 SSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRD 371
Query: 373 VIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPS 431
V++ INK+AF +E+P+IL +ENHCSI+QQ+ + Q++K + GDKL +S + E LPS
Sbjct: 372 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPS 431
Query: 432 PDVLKGKILIKAKKLSSNC--SGVEGDVTDEDEGAEM 466
P LKGKIL+K KKL + EG+V+DED E+
Sbjct: 432 PQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEI 468
Score = 227 bits (578), Expect = 5e-59
Identities = 130/331 (39%), Positives = 188/331 (56%), Gaps = 23/331 (6%)
Query: 437 GKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQ--RMGKENMEQPNNVPVKRFQLCKELSE 494
GK K S + S + + T + G E Q R+G+ K +LC+ELS+
Sbjct: 553 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRR---------KTMKLCRELSD 603
Query: 495 LVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPM 554
LV SV ++ V SF+E A + + F+ YN++ L R++PS
Sbjct: 604 LVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660
Query: 555 RIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFF 614
RIDSSN NP +W GCQ+VA+N+Q+ G MM LN F+ NGNCGYVL+P M + F
Sbjct: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--F 718
Query: 615 SANTKDSVPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQR 672
+ + D +P + L +K+ISGQ PKP S G +G+++DP+V VEI G+P DC + +
Sbjct: 719 NPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ 778
Query: 673 TKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 732
T+ V NG P+++E+ F +++PE+A+VRF+V D D IG +F+GQ T+ F L GYRH
Sbjct: 779 TRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRH 838
Query: 733 VPLQSLTGEVLAHASLFVHVAITNRRGGGKP 763
V L+ LT AS+FVH+ I G P
Sbjct: 839 VYLEGLT-----EASIFVHITINEIYGKWSP 864
>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
Length = 1693
Score = 344 bits (882), Expect = 3e-94
Identities = 189/457 (41%), Positives = 279/457 (61%), Gaps = 9/457 (1%)
Query: 13 CINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGK 72
C++ M G+++ K++ ++ R F LD LRW PS+K SEKAKI I SI +V G+
Sbjct: 18 CMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK-SEKAKILIDSIYKVTEGR 76
Query: 73 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 132
++IF C F++ +G + ESLDL+ ++ + A W+TGL+YL++ G D
Sbjct: 77 QSEIFHRQA-EGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMA-GISDED 134
Query: 133 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKS 192
L Q WV Q F E D + G + + Q + LN L K+ F+E
Sbjct: 135 SLAKRQ-RTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTD 193
Query: 193 KDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINE 252
+++ GT +T EEF + + R ++Y LL+ +S K+ L ++L FL+ EQ + ++
Sbjct: 194 ENQ-GT-LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTT 251
Query: 253 EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFIN 312
+ L+II K+E S+E + K L I+GFTN++ SP C IF+P H +V QDM QPL +Y+I
Sbjct: 252 DYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIA 311
Query: 313 SSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRS 372
SSHNTYL DQ S + Y R L+ GCR VE+D WDGPD EPV++ G+T+TS+I+FR
Sbjct: 312 SSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRD 371
Query: 373 VIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPS 431
V++ INK+AF +E+P+IL +ENHCSI+QQ+ + Q++K + GDKL +S + E LPS
Sbjct: 372 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPS 431
Query: 432 PDVLKGKILIKAKKLSSNC--SGVEGDVTDEDEGAEM 466
P LKGKIL+K KKL + EG+V+DED E+
Sbjct: 432 PQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEI 468
Score = 227 bits (578), Expect = 5e-59
Identities = 130/331 (39%), Positives = 188/331 (56%), Gaps = 23/331 (6%)
Query: 437 GKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQ--RMGKENMEQPNNVPVKRFQLCKELSE 494
GK K S + S + + T + G E Q R+G+ K +LC+ELS+
Sbjct: 553 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRR---------KTMKLCRELSD 603
Query: 495 LVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPM 554
LV SV ++ V SF+E A + + F+ YN++ L R++PS
Sbjct: 604 LVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660
Query: 555 RIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFF 614
RIDSSN NP +W GCQ+VA+N+Q+ G MM LN F+ NGNCGYVL+P M + F
Sbjct: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--F 718
Query: 615 SANTKDSVPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQR 672
+ + D +P + L +K+ISGQ PKP S G +G+++DP+V VEI G+P DC + +
Sbjct: 719 NPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ 778
Query: 673 TKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 732
T+ V NG P+++E+ F +++PE+A+VRF+V D D IG +F+GQ T+ F L GYRH
Sbjct: 779 TRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRH 838
Query: 733 VPLQSLTGEVLAHASLFVHVAITNRRGGGKP 763
V L+ LT AS+FVH+ I G P
Sbjct: 839 VYLEGLT-----EASIFVHITINEIYGKWSP 864
>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
Length = 1655
Score = 340 bits (873), Expect = 3e-93
Identities = 188/453 (41%), Positives = 276/453 (60%), Gaps = 9/453 (1%)
Query: 17 MVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDI 76
M G+++ K++ ++ R F LD LRW PS+K SEKAKI I SI +V G+ ++I
Sbjct: 4 MQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK-SEKAKILIDSIYKVTEGRQSEI 62
Query: 77 FRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 136
F C F++ +G + ESLDL+ ++ + A W+TGL+YL++ G D L
Sbjct: 63 FHRQA-EGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMA-GISDEDSLAK 120
Query: 137 SQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKA 196
Q WV Q F E D + G + + Q + LN L K+ F+E +++
Sbjct: 121 RQ-RTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQ- 178
Query: 197 GTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISL 256
GT +T EEF + + R ++Y LL+ +S K+ L ++L FL+ EQ + ++ + L
Sbjct: 179 GT-LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCL 237
Query: 257 EIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHN 316
+II K+E S+E + K L I+GFTN++ SP C IF+P H +V QDM QPL +Y+I SSHN
Sbjct: 238 DIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHN 297
Query: 317 TYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDI 376
TYL DQ S + Y R L+ GCR VE+D WDGPD EPV++ G+T+TS+I+FR V++
Sbjct: 298 TYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVET 357
Query: 377 INKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPSPDVL 435
INK+AF +E+P+IL +ENHCSI+QQ+ + Q++K + GDKL +S + E LPSP L
Sbjct: 358 INKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSL 417
Query: 436 KGKILIKAKKLSSNC--SGVEGDVTDEDEGAEM 466
KGKIL+K KKL + EG+V+DED E+
Sbjct: 418 KGKILVKGKKLPYHLGDDAEEGEVSDEDSADEI 450
Score = 226 bits (577), Expect = 6e-59
Identities = 135/349 (38%), Positives = 195/349 (55%), Gaps = 24/349 (6%)
Query: 437 GKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQ--RMGKENMEQPNNVPVKRFQLCKELSE 494
GK K S + S + + T + G E Q R+G+ K +LC+ELS+
Sbjct: 535 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRR---------KTMKLCRELSD 585
Query: 495 LVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPM 554
LV SV ++ V SF+E A + + F+ YN++ L R++PS
Sbjct: 586 LVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 642
Query: 555 RIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFF 614
RIDSSN NP +W GCQ+VA+N+Q+ G MM LN F+ NGNCGYVL+P M + F
Sbjct: 643 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--F 700
Query: 615 SANTKDSVPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQR 672
+ + D +P + L +K+ISGQ PKP S G +G+++DP+V VEI G+P DC + +
Sbjct: 701 NPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ 760
Query: 673 TKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 732
T+ V NG P+++E+ F +++PE+A+VRF+V D D IG +F+GQ T+ F L GYRH
Sbjct: 761 TRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRH 820
Query: 733 VPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYAS 781
V L+ LT AS+FVH+ I N G +GL K R +S
Sbjct: 821 VYLEGLT-----EASIFVHITI-NEIYGKNRQLQGLKGLFNKNPRHSSS 863
>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
Length = 1194
Score = 336 bits (861), Expect = 7e-92
Identities = 259/829 (31%), Positives = 400/829 (48%), Gaps = 120/829 (14%)
Query: 19 EGSELKKVRSNSRIYHRYFLLDADMQS--LRWEPSKKDSEKAKIDIKSIKEVRTG----- 71
EG+ + S ++ L D L W K+ + + + I +R+G
Sbjct: 19 EGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSL--INSIRSGAIPKD 76
Query: 72 -KNTDIFRSNGISDQISEDCAFSVIYGENYESLD---LVANSADVANIWVTGLRYLISYG 127
K + G S+ E V G + ++ +VA + +V WV GLR +I
Sbjct: 77 PKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIH-- 134
Query: 128 KHTLDMLESSQDNMRTSWVSQMFS-EIDVDNLGHITLCNAVQCIRNLNPGLKTSKIEL-- 184
N R + VS M + L +T N +R++ + K E
Sbjct: 135 ------------NFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVI 182
Query: 185 --KFKELH----KSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNK-EFLDTKDL 237
KEL K+ + T + E+F E+ ++C R +I L + + +K ++L L
Sbjct: 183 FQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQL 242
Query: 238 MMFLEAEQGVAHINEEI--------SLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCY 289
+ FL Q +NE + +++II YEP ++ ++KG +S DGF YLMS +
Sbjct: 243 VSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENA 302
Query: 290 IFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVW 349
+ ++ Q+M PL+HYFI+SSHNTYL QF G S + Y + L GCR VELD W
Sbjct: 303 PVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCW 362
Query: 350 D--GPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQ 407
D G D EP+I G M + I+F+ VI I + AF SEYP+IL ENHCS QQ M +
Sbjct: 363 DGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSK 422
Query: 408 HMKKLLGDKL----YTTSPNVEESYLPSPDVLKGKILIKAKKL----------------- 446
+ + L GD L + P LPSP+ LK KILIK K+L
Sbjct: 423 YCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMME 482
Query: 447 ----SSNCSGVEGDVTDEDEGAEMSQ------RMGKE-------------NMEQPNNVPV 483
+S + +E D +E E A+ + + G E N + V V
Sbjct: 483 AGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTV 542
Query: 484 KRFQ--------------LCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASK 529
+ Q + LS +++ + V+F+ F V+ + ++ + SFNE +
Sbjct: 543 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLG 602
Query: 530 YANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNI 589
Y + +FVNYNKR ++R++P R+DSSN PQ FW GCQ+V++N+QTP L M LN
Sbjct: 603 YLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQ 662
Query: 590 GWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAK 649
G F NG+CGY+L+P MR F ++ V GV +++ISGQ K
Sbjct: 663 GKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKK----- 717
Query: 650 GDVVDPYVYVEIHGIPADC--AEQRTKTVHQNGDAPIF-DESFEF-QINLPELAMVRFVV 705
+ YV V+++G+P D E RT+ V NG P++ +ESF F ++ LP+LA++R V
Sbjct: 718 ---IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAV 774
Query: 706 LDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 754
DD+ ++ IGQ +P + LQ GYRH+ L++ + L+ ++F ++ +
Sbjct: 775 YDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVL 820
>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
Length = 1175
Score = 336 bits (861), Expect = 7e-92
Identities = 259/829 (31%), Positives = 400/829 (48%), Gaps = 120/829 (14%)
Query: 19 EGSELKKVRSNSRIYHRYFLLDADMQS--LRWEPSKKDSEKAKIDIKSIKEVRTG----- 71
EG+ + S ++ L D L W K+ + + + I +R+G
Sbjct: 19 EGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSL--INSIRSGAIPKD 76
Query: 72 -KNTDIFRSNGISDQISEDCAFSVIYGENYESLD---LVANSADVANIWVTGLRYLISYG 127
K + G S+ E V G + ++ +VA + +V WV GLR +I
Sbjct: 77 PKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIH-- 134
Query: 128 KHTLDMLESSQDNMRTSWVSQMFS-EIDVDNLGHITLCNAVQCIRNLNPGLKTSKIEL-- 184
N R + VS M + L +T N +R++ + K E
Sbjct: 135 ------------NFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVI 182
Query: 185 --KFKELH----KSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNK-EFLDTKDL 237
KEL K+ + T + E+F E+ ++C R +I L + + +K ++L L
Sbjct: 183 FQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQL 242
Query: 238 MMFLEAEQGVAHINEEI--------SLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCY 289
+ FL Q +NE + +++II YEP ++ ++KG +S DGF YLMS +
Sbjct: 243 VSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENA 302
Query: 290 IFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVW 349
+ ++ Q+M PL+HYFI+SSHNTYL QF G S + Y + L GCR VELD W
Sbjct: 303 PVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCW 362
Query: 350 D--GPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQ 407
D G D EP+I G M + I+F+ VI I + AF SEYP+IL ENHCS QQ M +
Sbjct: 363 DGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSK 422
Query: 408 HMKKLLGDKL----YTTSPNVEESYLPSPDVLKGKILIKAKKL----------------- 446
+ + L GD L + P LPSP+ LK KILIK K+L
Sbjct: 423 YCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMME 482
Query: 447 ----SSNCSGVEGDVTDEDEGAEMSQ------RMGKE-------------NMEQPNNVPV 483
+S + +E D +E E A+ + + G E N + V V
Sbjct: 483 AGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTV 542
Query: 484 KRFQ--------------LCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASK 529
+ Q + LS +++ + V+F+ F V+ + ++ + SFNE +
Sbjct: 543 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLG 602
Query: 530 YANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNI 589
Y + +FVNYNKR ++R++P R+DSSN PQ FW GCQ+V++N+QTP L M LN
Sbjct: 603 YLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQ 662
Query: 590 GWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAK 649
G F NG+CGY+L+P MR F ++ V GV +++ISGQ K
Sbjct: 663 GKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKK----- 717
Query: 650 GDVVDPYVYVEIHGIPADC--AEQRTKTVHQNGDAPIF-DESFEF-QINLPELAMVRFVV 705
+ YV V+++G+P D E RT+ V NG P++ +ESF F ++ LP+LA++R V
Sbjct: 718 ---IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAV 774
Query: 706 LDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 754
DD+ ++ IGQ +P + LQ GYRH+ L++ + L+ ++F ++ +
Sbjct: 775 YDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVL 820
>gi|12083581 phosphoinositide-specific phospholipase C beta 1
isoform a [Homo sapiens]
Length = 1216
Score = 326 bits (835), Expect = 8e-89
Identities = 247/802 (30%), Positives = 392/802 (48%), Gaps = 88/802 (10%)
Query: 15 NSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNT 74
+S+ +G++ K +S I +L D Q + + ++ E +D+ +K+ R G++
Sbjct: 20 DSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHA 78
Query: 75 DIFRSNGISDQIS-------EDCAFSVIYGE---NYESLDLVANSADVANIWVTGLRYLI 124
+ + + + E +V+YG N L+LVA +VA W + L
Sbjct: 79 KAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLA 138
Query: 125 SYGKHTLDMLESSQDNMRTSWVSQMFSEI--DVDNLGHITLCNAVQCIRNLNPGLKTSKI 182
+ ++L +Q+ R +++ + ++++ V G I L N R + K +
Sbjct: 139 T------NLL--AQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIY---RLFSADRKRVET 187
Query: 183 ELKFKELHKSKDKA--GTEVTKEEFIEVFHELCTRPEIYFLLVQFSS-NKEFLDTKDLMM 239
L+ L S++ + + T E + + LC RPEI + +F + +K +L +M
Sbjct: 188 ALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMD 247
Query: 240 FLEAEQGVAHINE--------EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIF 291
F+ +Q +NE E +I KYEP+ KG +S+DGF YL + +
Sbjct: 248 FINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVV 307
Query: 292 DPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDG 351
PE + +DM QPLSHYFINSSHNTYL Q G S + Y + L GCR VELD W G
Sbjct: 308 SPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKG 367
Query: 352 --PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHC-SIKQQKVMVQH 408
+ EPVI G TMT++I F+ VI+ I + AF S +P++L ENH S KQQ M ++
Sbjct: 368 RTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEY 427
Query: 409 MKKLLGDKLYTTS----PNVEESYLPSPDVLKGKILIKAKKLS---SNCSGVE------- 454
+ + GD L P LPSP L KIL+K KK S S SG +
Sbjct: 428 CRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQAS 487
Query: 455 -----------------GDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVS 497
G+ E + + K +M++ +E+S LV+
Sbjct: 488 NTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDE--GTAGSEAMATEEMSNLVN 545
Query: 498 ICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRID 557
+ V+F+ F++S + K +E+ SF E + ++P +FV YNK L+R++P R+D
Sbjct: 546 YIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVD 605
Query: 558 SSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSAN 617
SSN PQ FW GCQ+VA+NFQT L M +N+G + NG GY L+P MR F
Sbjct: 606 SSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPF 665
Query: 618 TKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKT 675
T+ V G+ L +KIISGQ K V YV V++ G+P D + +TKT
Sbjct: 666 TEGIVDGIVANTLSVKIISGQFLSDKK--------VGTYVEVDMFGLPVDTRRKAFKTKT 717
Query: 676 VHQNGDAPIFDES---FEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 732
N P+++E F+ ++ LP LA +R V ++ G +FIG +P + ++ GY +
Sbjct: 718 SQGNAVNPVWEEEPIVFK-KVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHY 773
Query: 733 VPLQSLTGEVLAHASLFVHVAI 754
+ L++ + L ++FV++ +
Sbjct: 774 ICLRNERNQPLTLPAVFVYIEV 795
>gi|33356544 phosphoinositide-specific phospholipase C beta 1
isoform b [Homo sapiens]
Length = 1173
Score = 326 bits (835), Expect = 8e-89
Identities = 247/802 (30%), Positives = 392/802 (48%), Gaps = 88/802 (10%)
Query: 15 NSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNT 74
+S+ +G++ K +S I +L D Q + + ++ E +D+ +K+ R G++
Sbjct: 20 DSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHA 78
Query: 75 DIFRSNGISDQIS-------EDCAFSVIYGE---NYESLDLVANSADVANIWVTGLRYLI 124
+ + + + E +V+YG N L+LVA +VA W + L
Sbjct: 79 KAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLA 138
Query: 125 SYGKHTLDMLESSQDNMRTSWVSQMFSEI--DVDNLGHITLCNAVQCIRNLNPGLKTSKI 182
+ ++L +Q+ R +++ + ++++ V G I L N R + K +
Sbjct: 139 T------NLL--AQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIY---RLFSADRKRVET 187
Query: 183 ELKFKELHKSKDKA--GTEVTKEEFIEVFHELCTRPEIYFLLVQFSS-NKEFLDTKDLMM 239
L+ L S++ + + T E + + LC RPEI + +F + +K +L +M
Sbjct: 188 ALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMD 247
Query: 240 FLEAEQGVAHINE--------EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIF 291
F+ +Q +NE E +I KYEP+ KG +S+DGF YL + +
Sbjct: 248 FINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVV 307
Query: 292 DPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDG 351
PE + +DM QPLSHYFINSSHNTYL Q G S + Y + L GCR VELD W G
Sbjct: 308 SPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKG 367
Query: 352 --PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHC-SIKQQKVMVQH 408
+ EPVI G TMT++I F+ VI+ I + AF S +P++L ENH S KQQ M ++
Sbjct: 368 RTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEY 427
Query: 409 MKKLLGDKLYTTS----PNVEESYLPSPDVLKGKILIKAKKLS---SNCSGVE------- 454
+ + GD L P LPSP L KIL+K KK S S SG +
Sbjct: 428 CRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQAS 487
Query: 455 -----------------GDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVS 497
G+ E + + K +M++ +E+S LV+
Sbjct: 488 NTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDE--GTAGSEAMATEEMSNLVN 545
Query: 498 ICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRID 557
+ V+F+ F++S + K +E+ SF E + ++P +FV YNK L+R++P R+D
Sbjct: 546 YIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVD 605
Query: 558 SSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSAN 617
SSN PQ FW GCQ+VA+NFQT L M +N+G + NG GY L+P MR F
Sbjct: 606 SSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPF 665
Query: 618 TKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKT 675
T+ V G+ L +KIISGQ K V YV V++ G+P D + +TKT
Sbjct: 666 TEGIVDGIVANTLSVKIISGQFLSDKK--------VGTYVEVDMFGLPVDTRRKAFKTKT 717
Query: 676 VHQNGDAPIFDES---FEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 732
N P+++E F+ ++ LP LA +R V ++ G +FIG +P + ++ GY +
Sbjct: 718 SQGNAVNPVWEEEPIVFK-KVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHY 773
Query: 733 VPLQSLTGEVLAHASLFVHVAI 754
+ L++ + L ++FV++ +
Sbjct: 774 ICLRNERNQPLTLPAVFVYIEV 795
>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
Length = 1185
Score = 305 bits (780), Expect = 2e-82
Identities = 246/778 (31%), Positives = 374/778 (48%), Gaps = 100/778 (12%)
Query: 46 LRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDC--------AFSVIYG 97
L W K+ E +DI SI++ R GK + +S + D + D +V+ G
Sbjct: 47 LYWTYQSKEMEF--LDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSG 104
Query: 98 ENYESL---DLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEI- 153
+ L + V+ +V W + L+ KH L S R++++ ++ ++
Sbjct: 105 PDMVDLTFHNFVSYKENVGKAWAEDVLALV---KHPLTANAS-----RSTFLDKILVKLK 156
Query: 154 -DVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHE- 211
+++ G I + N Q ++E H K K + E+F E ++
Sbjct: 157 MQLNSEGKIPVKNFFQMFP-----ADRKRVEAALSACHLPKGK-NDAINPEDFPEPVYKS 210
Query: 212 ----LCTRPEIYFLLVQFSSN-KEFLDTKDLMMFLEAEQGVAHINEEISLE--------I 258
LC RPEI + + + K ++ + L F+ +Q + +N + +
Sbjct: 211 FLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGL 270
Query: 259 IHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTY 318
I KYEPS ++G LS +G +L P+ + + + DM QPL+HYFINSSHNTY
Sbjct: 271 IDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTY 330
Query: 319 LIEDQFRGPSDITGYIRALKMGCRSVELDVWDG--PDNEPVIYTGHTMTSQIVFRSVIDI 376
L QF G S Y + L GCR VELD W G PD EP+I G TMT+ I F+ I+
Sbjct: 331 LTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEA 390
Query: 377 INKYAFFASEYPLILCLENHC-SIKQQKVMVQHMKKLLGDKLYTTS----PNVEESYLPS 431
I + AF S YP+IL ENH S +QQ M ++ + + GD L T P LPS
Sbjct: 391 IAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPS 450
Query: 432 PDVLKGKILIKAKK-------LSSNCSGVE-------------GDVTDEDEGAEMSQR-M 470
P+ L+GKILIK KK SS +G E G V +EG E+ + +
Sbjct: 451 PEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEV 510
Query: 471 GKENMEQPNNVP---VKRFQ-----------LCKELSELVSICKSVQFKEFQVSFQVQKY 516
+E E+ N+ +K+ Q +E+S LV+ + +F F+ S Q +
Sbjct: 511 EEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRS 570
Query: 517 WEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAM 576
+ + SF E+ A ++ FV+YNKR ++R++P R+DSSN PQ FW GCQ+VA+
Sbjct: 571 YVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVAL 630
Query: 577 NFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIIS 636
NFQT L M N+ F NG GY+L+ MR F+ + D + V L I +IS
Sbjct: 631 NFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVIS 690
Query: 637 GQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ-RTK-TVHQNGDAPIF-DESFEFQ- 692
GQ + V YV VE+ G+P D + RTK + N P++ +E F F+
Sbjct: 691 GQFLSERS--------VRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEK 742
Query: 693 INLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 750
I +PELA +R V+++ G++F+G IP L +GY H+ L S + L +LF+
Sbjct: 743 ILMPELASLRVAVMEE---GNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFI 797
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 218 bits (554), Expect = 3e-56
Identities = 143/444 (32%), Positives = 225/444 (50%), Gaps = 40/444 (9%)
Query: 27 RSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQI 86
+ + R + F + + + + W E A IDI+ IKE+R GK + F D+
Sbjct: 41 KKSQRPERKTFQVKLETRQITWSRGADKIEGA-IDIREIKEIRPGKTSRDF------DRY 93
Query: 87 SEDCAFS--------VIYGENY--ESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 136
ED AF ++YG + ++L L A S D N+W+ GL +L+ D L++
Sbjct: 94 QEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLME------DTLQA 147
Query: 137 SQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKA 196
W+ + F +D + I+ + + +N + + +E ++
Sbjct: 148 PTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRF---LRERLTDLEQR 204
Query: 197 GTEVTKEEFIEVFHELCTR-------PEIYFLLVQFSSNKEF--LDTKDLMMFLEAEQGV 247
++T +F +++ L P + ++ E + + FL QG
Sbjct: 205 SGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGE 264
Query: 248 AHINEEISLE---IIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQD-MK 303
+ + ++ + +P +E +E + +D F +L S + +++ + VC D M
Sbjct: 265 LWAVDRLQVQEFMLSFLRDPLREIEEP-YFFLDEFVTFLFSKENSVWNSQLDAVCPDTMN 323
Query: 304 QPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHT 363
PLSHY+I+SSHNTYL DQF S + Y R L+MGCR +ELD WDGPD PVIY GHT
Sbjct: 324 NPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHT 383
Query: 364 MTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPN 423
+T++I F V+ I ++AF ASEYP+IL +E+HCSI QQ+ M Q+ KK+LGD L T
Sbjct: 384 LTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVE 443
Query: 424 VEESYLPSPDVLKGKILIKAKKLS 447
+ LPSP+ LK KILIK KKL+
Sbjct: 444 ISADGLPSPNQLKRKILIKHKKLA 467
Score = 187 bits (475), Expect = 4e-47
Identities = 108/274 (39%), Positives = 162/274 (59%), Gaps = 10/274 (3%)
Query: 484 KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGD-FVNYN 542
+R ++ ELSELV C+ V F E ++ + Y ++ SF E A KY N+ G F+ YN
Sbjct: 945 RRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYN 1004
Query: 543 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 602
+ L+R++P R+DSSN +P W CG Q+VA+NFQTP M +N F +CGYVL
Sbjct: 1005 RLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVL 1064
Query: 603 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 662
+P+ MR+E F K S+ G+ P + I+++ ++ PK G G +V P+V +E+
Sbjct: 1065 QPSTMRDEA--FDPFDKSSLRGLEPCAISIEVLGARHLPK-NGRG----IVCPFVEIEVA 1117
Query: 663 GIPADCAEQRTKTVHQNGDAPIFD-ESFEFQINLPELAMVRFVVLDDDYIGDE-FIGQYT 720
G D +Q+T+ V NG P++ + F FQI+ PE A +RFVV ++D D+ F+ Q T
Sbjct: 1118 GAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQAT 1177
Query: 721 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 754
P + L+TGYR VPL++ E L ASL + + I
Sbjct: 1178 FPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 218 bits (554), Expect = 3e-56
Identities = 143/444 (32%), Positives = 225/444 (50%), Gaps = 40/444 (9%)
Query: 27 RSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQI 86
+ + R + F + + + + W E A IDI+ IKE+R GK + F D+
Sbjct: 41 KKSQRPERKTFQVKLETRQITWSRGADKIEGA-IDIREIKEIRPGKTSRDF------DRY 93
Query: 87 SEDCAFS--------VIYGENY--ESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 136
ED AF ++YG + ++L L A S D N+W+ GL +L+ D L++
Sbjct: 94 QEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLME------DTLQA 147
Query: 137 SQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKA 196
W+ + F +D + I+ + + +N + + +E ++
Sbjct: 148 PTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRF---LRERLTDLEQR 204
Query: 197 GTEVTKEEFIEVFHELCTR-------PEIYFLLVQFSSNKEF--LDTKDLMMFLEAEQGV 247
++T +F +++ L P + ++ E + + FL QG
Sbjct: 205 SGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGE 264
Query: 248 AHINEEISLE---IIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQD-MK 303
+ + ++ + +P +E +E + +D F +L S + +++ + VC D M
Sbjct: 265 LWAVDRLQVQEFMLSFLRDPLREIEEP-YFFLDEFVTFLFSKENSVWNSQLDAVCPDTMN 323
Query: 304 QPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHT 363
PLSHY+I+SSHNTYL DQF S + Y R L+MGCR +ELD WDGPD PVIY GHT
Sbjct: 324 NPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHT 383
Query: 364 MTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPN 423
+T++I F V+ I ++AF ASEYP+IL +E+HCSI QQ+ M Q+ KK+LGD L T
Sbjct: 384 LTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVE 443
Query: 424 VEESYLPSPDVLKGKILIKAKKLS 447
+ LPSP+ LK KILIK KKL+
Sbjct: 444 ISADGLPSPNQLKRKILIKHKKLA 467
Score = 188 bits (477), Expect = 2e-47
Identities = 115/301 (38%), Positives = 170/301 (56%), Gaps = 15/301 (4%)
Query: 484 KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGD-FVNYN 542
+R ++ ELSELV C+ V F E ++ + Y ++ SF E A KY N+ G F+ YN
Sbjct: 945 RRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYN 1004
Query: 543 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 602
+ L+R++P R+DSSN +P W CG Q+VA+NFQTP M +N F +CGYVL
Sbjct: 1005 RLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVL 1064
Query: 603 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 662
+P+ MR+E F K S+ G+ P + I+++ ++ PK G G +V P+V +E+
Sbjct: 1065 QPSTMRDEA--FDPFDKSSLRGLEPCAISIEVLGARHLPK-NGRG----IVCPFVEIEVA 1117
Query: 663 GIPADCAEQRTKTVHQNGDAPIFD-ESFEFQINLPELAMVRFVVLDDDYIGDE-FIGQYT 720
G D +Q+T+ V NG P++ + F FQI+ PE A +RFVV ++D D+ F+ Q T
Sbjct: 1118 GAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQAT 1177
Query: 721 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA 780
P + L+TGYR VPL++ E L ASL + + I + G LS G RE
Sbjct: 1178 FPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENG-----DLSPFSGTSLRERG 1232
Query: 781 S 781
S
Sbjct: 1233 S 1233
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 213 bits (541), Expect = 9e-55
Identities = 145/446 (32%), Positives = 225/446 (50%), Gaps = 56/446 (12%)
Query: 54 DSEKAKIDIKSIKEVRTGKNT-DIFRSNGISDQISEDCAFSVIYGENY--ESLDLVANSA 110
D + +DI IKE+R GKN+ D R+ + + EDC F+++YG + +L L A+S
Sbjct: 59 DKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQK--EDCCFTILYGTQFVLSTLSLAADSK 116
Query: 111 DVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCI 170
+ A W++GL+ L + + +S + SW+ + +D I+L +
Sbjct: 117 EDAVNWLSGLKILHQ------EAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTIL 170
Query: 171 RNLNPGLKTSK-IELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNK 229
+N + ++K ++ KF E+ KD+ E FH +++ + F K
Sbjct: 171 PLINFKVSSAKFLKDKFVEIGAHKDELS--------FEQFH-------LFYKKLMFEQQK 215
Query: 230 EFLDT--KDLMMFL---------------EAEQGVAHINEEISLEIIHKY--------EP 264
LD KD +F+ + ++ + H +E + ++K +
Sbjct: 216 SILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDD 275
Query: 265 SKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKV-CQDMKQPLSHYFINSSHNTYLIEDQ 323
+ + +L +D F YL S + I+D ++ V QDM PLSHY+I+SSHNTYL DQ
Sbjct: 276 TMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQ 335
Query: 324 FRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFF 383
R S YIR L+MGCR +ELD WDGPD +PVIY G T T++I F V+ I +AF
Sbjct: 336 LRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFV 395
Query: 384 ASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKILIKA 443
S +P+IL +E HCS++QQ+ M + K++ GD L T LPSP L+ KI+IK
Sbjct: 396 TSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKH 455
Query: 444 KKLSSNCSGVEGDVTDEDEGAEMSQR 469
KKL + DV ED+ E Q+
Sbjct: 456 KKLGPR---GDVDVNMEDKKDEHKQQ 478
Score = 144 bits (362), Expect = 5e-34
Identities = 96/275 (34%), Positives = 142/275 (51%), Gaps = 22/275 (8%)
Query: 484 KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNK 543
K + ELS+LV CK + + + + + E+ SF E A + P D + YN+
Sbjct: 922 KNQSIAIELSDLVVYCKPTS--KTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQ 979
Query: 544 RFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLR 603
+ L RV+P R+DSSN +P W CG Q+VA+NFQT M +N F NG GYVL+
Sbjct: 980 KGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQ 1039
Query: 604 PAIMREEVSFFSANTKDSVPGVSPQ----LLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 659
P MR E D +P S + L +K++ ++ PK S + P+V V
Sbjct: 1040 PESMRTE-------KYDPMPPESQRKILMTLTVKVLGARHLPKLGRS-----IACPFVEV 1087
Query: 660 EIHGIPADCAEQRTKTVHQNGDAPIF---DESFEFQINLPELAMVRFVVLDDDYIGD-EF 715
EI G D + +T V+ NG +PI+ E F+I P LA +RFVV ++D D F
Sbjct: 1088 EICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNF 1147
Query: 716 IGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 750
+ T P + +++G+R VPL++ E + ASL V
Sbjct: 1148 LAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182
>gi|11386139 phospholipase C beta 3 [Homo sapiens]
Length = 1234
Score = 181 bits (459), Expect = 3e-45
Identities = 135/418 (32%), Positives = 214/418 (51%), Gaps = 44/418 (10%)
Query: 60 IDIKSIKEVRTGKNTDIFRSNGISDQIS--------EDCAFSVIYGE---NYESLDLVAN 108
+DI SI++ RTG+ + + I + + E+ +V+ G N L+ +A
Sbjct: 64 LDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAV 123
Query: 109 SADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEI--DVDNLGHITLCNA 166
D A +W L L M +Q+ R +++ + ++++ V+ G I + N
Sbjct: 124 QDDTAKVWSEEL--------FKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNI 175
Query: 167 VQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFS 226
++ ++T+ +E + ++S+ E + E F ++LC RP+I +L++
Sbjct: 176 LKMFSADKKRVETA-LESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIG 234
Query: 227 SN-KEFLDTKDLMMFLEAEQGVAHINEEI--------SLEIIHKYEPSKEGQEKGWLSID 277
+ K +L + LM F+ +Q +NE + + +I KYEP+++ E+ +S++
Sbjct: 235 AKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSME 294
Query: 278 GFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRAL 337
GF+ YL + I E + DM QPLS YFINSSHNTYL Q G S + Y +AL
Sbjct: 295 GFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQAL 354
Query: 338 KMGCRSVELDVWDG--PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLEN 395
GCR VELDVW G P+ EP I G TMT+++ R V++ I + AF S YP+IL EN
Sbjct: 355 LWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFEN 414
Query: 396 HC-SIKQQKVMVQHMKKLLGDKL-------YTTSPNVEESYLPSPDVLKGKILIKAKK 445
H S KQQ M ++ + + GD L Y +P V LPSP L G+IL+K KK
Sbjct: 415 HVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVP---LPSPQDLMGRILVKNKK 469
Score = 171 bits (432), Expect = 4e-42
Identities = 101/299 (33%), Positives = 159/299 (53%), Gaps = 14/299 (4%)
Query: 456 DVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQK 515
D DE+E E ++ + +E+S LV+ + V+FK F+ + + K
Sbjct: 554 DREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNK 613
Query: 516 YWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVA 575
+E+ SF E A + ++P +FV YNK+ L+R++P R+DSSN PQ FW GCQ+VA
Sbjct: 614 CFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVA 673
Query: 576 MNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKII 635
+NFQT + M LN G F NG GY+L+P MR F T+ V G+ L +K+I
Sbjct: 674 LNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVI 733
Query: 636 SGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ-RTKTVHQNGDAPIFDES-FEF-Q 692
SGQ K V YV V++ G+P D + RT+T N P++DE F+F +
Sbjct: 734 SGQFLSDRK--------VGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPK 785
Query: 693 INLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVH 751
+ LP LA +R ++ G +F+G +P +++GY +V L++ + L +L ++
Sbjct: 786 VVLPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIY 841
>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
Length = 2302
Score = 170 bits (431), Expect = 5e-42
Identities = 86/211 (40%), Positives = 134/211 (63%), Gaps = 5/211 (2%)
Query: 249 HINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIF-DPEHKKVCQDMKQPLS 307
H + L II K+EPS +G +S +GF +LM + + + E ++ ++++ PLS
Sbjct: 1340 HCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDESQENIKELQLPLS 1399
Query: 308 HYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQ 367
+Y+I SSHNTYL Q +G S + Y + L GCRSVELD WDG D P+IY GHT+T++
Sbjct: 1400 YYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGMPIIYHGHTLTTK 1459
Query: 368 IVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYT----TSPN 423
I F+ V++ I++ AF S+ P+I+ +ENHCS+ QQ+ M + K + G+KL T +
Sbjct: 1460 IPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEKLVTKFLFETDF 1519
Query: 424 VEESYLPSPDVLKGKILIKAKKLSSNCSGVE 454
++ LPSPD L+ K+L+K KKL ++ + V+
Sbjct: 1520 SDDPMLPSPDQLRKKVLLKNKKLKAHQTPVD 1550
Score = 141 bits (355), Expect = 3e-33
Identities = 81/241 (33%), Positives = 128/241 (53%), Gaps = 13/241 (5%)
Query: 515 KYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIV 574
K + + S NE A + + L R +P+ RIDSSN NP FW G Q+V
Sbjct: 1753 KCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLV 1812
Query: 575 AMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREE----VSFFSANTKDSVPGVSPQLL 630
A+N+QT L + LN F NG CGYVL+P ++ ++ FS +D + + P +
Sbjct: 1813 ALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERD-LDSMDPAVY 1871
Query: 631 HIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFE 690
+ I+SGQN G+ P + V++ G+P D RTK +H+N P+++E F
Sbjct: 1872 SLTIVSGQNVCPSNSMGS------PCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFL 1925
Query: 691 FQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 750
F ++ +L +RF V++++ Q IP + L+ GYRH+ L++L EVL +SLF+
Sbjct: 1926 FHVHFEDLVFLRFAVVENN--SSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFI 1983
Query: 751 H 751
+
Sbjct: 1984 N 1984
>gi|23943920 cytosolic phospholipase A2, group IVA [Homo sapiens]
Length = 749
Score = 43.9 bits (102), Expect = 8e-04
Identities = 27/87 (31%), Positives = 48/87 (55%), Gaps = 8/87 (9%)
Query: 647 GAKGDVVD---PYVYVEIHGIPADCAEQRTKTVHQNGDA-PIFDESFEFQINLPELAMVR 702
GA GD++D PYV + I P + R +T H N D P+++E+FEF ++ + ++
Sbjct: 33 GAFGDMLDTPDPYVELFISTTP----DSRKRTRHFNNDINPVWNETFEFILDPNQENVLE 88
Query: 703 FVVLDDDYIGDEFIGQYTIPFECLQTG 729
++D +Y+ DE +G T ++ G
Sbjct: 89 ITLMDANYVMDETLGTATFTVSSMKVG 115
>gi|61742814 coiled-coil and C2 domain containing 1B [Homo sapiens]
Length = 858
Score = 41.6 bits (96), Expect = 0.004
Identities = 22/65 (33%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 630 LHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESF 689
+H+ I+ G N P P G D +D +V E H +D A++ V +N ++P FD+ F
Sbjct: 701 MHLIIVRGMNLPAPPG--VTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLF 758
Query: 690 EFQIN 694
+ IN
Sbjct: 759 KLNIN 763
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 40.8 bits (94), Expect = 0.006
Identities = 31/104 (29%), Positives = 56/104 (53%), Gaps = 9/104 (8%)
Query: 628 QLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPA--DCAEQRTKTVHQNGDAPIF 685
++L +K++SG + K GA DPYV + ++ + A +TKT+ + + P +
Sbjct: 20 RILRVKVVSGIDLAKKDIFGAS----DPYVKLSLYVADENRELALVQTKTIKKTLN-PKW 74
Query: 686 DESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPFECLQT 728
+E F F++N P + F V D++ + D+F+GQ +P L T
Sbjct: 75 NEEFYFRVN-PSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPT 117
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 40.8 bits (94), Expect = 0.006
Identities = 31/104 (29%), Positives = 56/104 (53%), Gaps = 9/104 (8%)
Query: 628 QLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPA--DCAEQRTKTVHQNGDAPIF 685
++L +K++SG + K GA DPYV + ++ + A +TKT+ + + P +
Sbjct: 12 RILRVKVVSGIDLAKKDIFGAS----DPYVKLSLYVADENRELALVQTKTIKKTLN-PKW 66
Query: 686 DESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPFECLQT 728
+E F F++N P + F V D++ + D+F+GQ +P L T
Sbjct: 67 NEEFYFRVN-PSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPT 109
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 40.8 bits (94), Expect = 0.006
Identities = 31/104 (29%), Positives = 56/104 (53%), Gaps = 9/104 (8%)
Query: 628 QLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPA--DCAEQRTKTVHQNGDAPIF 685
++L +K++SG + K GA DPYV + ++ + A +TKT+ + + P +
Sbjct: 12 RILRVKVVSGIDLAKKDIFGAS----DPYVKLSLYVADENRELALVQTKTIKKTLN-PKW 66
Query: 686 DESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPFECLQT 728
+E F F++N P + F V D++ + D+F+GQ +P L T
Sbjct: 67 NEEFYFRVN-PSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPT 109
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 40.8 bits (94), Expect = 0.006
Identities = 31/104 (29%), Positives = 56/104 (53%), Gaps = 9/104 (8%)
Query: 628 QLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPA--DCAEQRTKTVHQNGDAPIF 685
++L +K++SG + K GA DPYV + ++ + A +TKT+ + + P +
Sbjct: 20 RILRVKVVSGIDLAKKDIFGAS----DPYVKLSLYVADENRELALVQTKTIKKTLN-PKW 74
Query: 686 DESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPFECLQT 728
+E F F++N P + F V D++ + D+F+GQ +P L T
Sbjct: 75 NEEFYFRVN-PSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPT 117
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 37.4 bits (85), Expect = 0.071
Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 10/95 (10%)
Query: 630 LHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESF 689
L ++I+ + P +G DPYV +I+ +P + +TK VH+ P+F+E+F
Sbjct: 316 LVVRILQALDLPAKDSNGFS----DPYV--KIYLLPDRKKKFQTK-VHRKTLNPVFNETF 368
Query: 690 EFQINLPELAM--VRFVVLD-DDYIGDEFIGQYTI 721
+F + L ELA + F V D D + + IGQ +
Sbjct: 369 QFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVL 403
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,290,310
Number of Sequences: 37866
Number of extensions: 1651964
Number of successful extensions: 4363
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 4163
Number of HSP's gapped (non-prelim): 118
length of query: 1001
length of database: 18,247,518
effective HSP length: 112
effective length of query: 889
effective length of database: 14,006,526
effective search space: 12451801614
effective search space used: 12451801614
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.