Search of human proteins with 157743284

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
         (1076 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                 2156   0.0  
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                  1251   0.0  
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                  1141   0.0  
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       293   5e-79
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        293   5e-79
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        293   5e-79
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       293   5e-79
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        293   5e-79
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        293   5e-79
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        293   5e-79
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        293   5e-79
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        291   2e-78
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   256   8e-68
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   234   3e-61
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   230   5e-60
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   226   7e-59
gi|34304381 inversin isoform a [Homo sapiens]                         201   2e-51
gi|34304379 inversin isoform b [Homo sapiens]                         201   2e-51
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   187   6e-47
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   175   2e-43
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   169   2e-41
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    169   2e-41
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    166   1e-40
gi|116534990 ankyrin-like protein 1 [Homo sapiens]                    165   2e-40
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform...   162   2e-39
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]            156   9e-38
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...   154   6e-37
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   146   9e-35
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   146   9e-35
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          141   3e-33

>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 2156 bits (5587), Expect = 0.0
 Identities = 1076/1076 (100%), Positives = 1076/1076 (100%)

Query: 1    MGILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLL 60
            MGILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLL
Sbjct: 1    MGILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLL 60

Query: 61   LMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRAT 120
            LMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRAT
Sbjct: 61   LMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRAT 120

Query: 121  KCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWA 180
            KCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWA
Sbjct: 121  KCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWA 180

Query: 181  AFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGN 240
            AFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGN
Sbjct: 181  AFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGN 240

Query: 241  TALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVN 300
            TALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVN
Sbjct: 241  TALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVN 300

Query: 301  YQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMT 360
            YQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMT
Sbjct: 301  YQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMT 360

Query: 361  NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPD 420
            NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPD
Sbjct: 361  NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPD 420

Query: 421  NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480
            NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA
Sbjct: 421  NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480

Query: 481  GVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNG 540
            GVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNG
Sbjct: 481  GVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNG 540

Query: 541  ADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEA 600
            ADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEA
Sbjct: 541  ADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEA 600

Query: 601  LKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAA 660
            LKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAA
Sbjct: 601  LKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAA 660

Query: 661  ASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLR 720
            ASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLR
Sbjct: 661  ASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLR 720

Query: 721  GRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALST 780
            GRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALST
Sbjct: 721  GRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALST 780

Query: 781  DPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTE 840
            DPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTE
Sbjct: 781  DPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTE 840

Query: 841  MLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAE 900
            MLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAE
Sbjct: 841  MLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAE 900

Query: 901  NGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSA 960
            NGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSA
Sbjct: 901  NGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSA 960

Query: 961  LQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKP 1020
            LQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKP
Sbjct: 961  LQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKP 1020

Query: 1021 FPPKDAVSPFSFSLLKNCSIAAAKTVGGCGALPHGASCPYSQERPGAIGLDGCYSE 1076
            FPPKDAVSPFSFSLLKNCSIAAAKTVGGCGALPHGASCPYSQERPGAIGLDGCYSE
Sbjct: 1021 FPPKDAVSPFSFSLLKNCSIAAAKTVGGCGALPHGASCPYSQERPGAIGLDGCYSE 1076


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score = 1251 bits (3238), Expect = 0.0
 Identities = 632/1056 (59%), Positives = 785/1056 (74%), Gaps = 56/1056 (5%)

Query: 1    MGILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLL 60
            M  L + DQP LVQAIF+ D +EVR+L+ +KE++N  D E+RTPLHAAAY+GD  I++LL
Sbjct: 1    MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELL 60

Query: 61   LMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRAT 120
            ++SGA VNAKD+ WLTPLHRA AS +E+ + +LL HSADVNARDK WQTPLH+AAAN+A 
Sbjct: 61   ILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAV 120

Query: 121  KCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWA 180
            KCAEAL PLLS++NV+DR+GR+ALHHA  SGH E V LLL++GA++N  DKK+R+ +HWA
Sbjct: 121  KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWA 180

Query: 181  AFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGN 240
            A++GH+EV+KLLV+ GA++ CKD+K Y  LH AA+SG I VVKYLL +G +++EPNA+GN
Sbjct: 181  AYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGN 240

Query: 241  TALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVN 300
            T LH+ACY GQD V  EL++ GA VNQ N+KGFTPLH AA ST+GALCLELLV NGADVN
Sbjct: 241  TPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVN 300

Query: 301  YQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMT 360
             +SK+GK+PLHM A+HGRF+RSQ +IQ+G+ IDC DK GNTPLH+AARYGHELLI+TL+T
Sbjct: 301  MKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT 360

Query: 361  NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPD 420
            +GADTA+RGIH MFPLHLA L GFSDCCRKLLSSG                  FDI+TPD
Sbjct: 361  SGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSG------------------FDIDTPD 402

Query: 421  NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480
            + GRTCLHAAA+GGN+ECLNLLL++GAD  ++DKFGR+PLHYAAAN +YQC   LV +GA
Sbjct: 403  DFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGA 462

Query: 481  GVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNG 540
             VN+ D +GC+PLHYAA SDT  +                           CLE+LL N 
Sbjct: 463  SVNDLDERGCTPLHYAATSDTDGK---------------------------CLEYLLRND 495

Query: 541  ADPSLRDRQGYTAVHYAAAYGNRQNLEL---------LLEMS-FNCLEDVESTIPVSPLH 590
            A+P +RD+QGY AVHY+AAYG+R  L+L         L+E S  + L D ++   +SPLH
Sbjct: 496  ANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLH 555

Query: 591  LAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERK 650
            LAAY+GH +AL+ L ++L++LDVR+  GRT L LA  +G  ECV+VL   GAS L+K+  
Sbjct: 556  LAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYI 615

Query: 651  RKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710
             K TP+HAAA +GH++ L LLI + E  +  D+ D  GQTPLML+++NGH DCV+ LL K
Sbjct: 616  LKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 675

Query: 711  GSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVL 770
            G+  DA D  GRTALHRGAVTG E+C+ ALL H A  L RD +GRTPIHL++ACGH  VL
Sbjct: 676  GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVL 735

Query: 771  RTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCA 830
              LLQ+A S D   A  D  GY+ +HWA Y GHE C+ELLLE   F   EGN F+PLHCA
Sbjct: 736  GALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCA 795

Query: 831  VINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT 890
            VIN+ +   EML+  LGA IVN+ D+KGRTPLHAAAF D+V  L++LL H A+VN+ D T
Sbjct: 796  VINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDST 855

Query: 891  GRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQD 950
            G+T LM AAENGQT  VE L+    A+LT+ D +KNTALHLACSKGHE  AL+IL +  D
Sbjct: 856  GKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITD 915

Query: 951  LGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADC 1010
              LINATN+ALQ PLH+AARNGL  VVQ LL  GA+VLAVDE G+TPALACAPNKDVADC
Sbjct: 916  RNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADC 975

Query: 1011 LALILSTMKPFPPKDAVSPFSFSLLKNCSIAAAKTV 1046
            LALIL+TM P      +S  +F+ + N     +KTV
Sbjct: 976  LALILATMMPVSSSSPLSSLTFNAI-NRYTNTSKTV 1010


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score = 1141 bits (2951), Expect = 0.0
 Identities = 572/936 (61%), Positives = 704/936 (75%), Gaps = 19/936 (2%)

Query: 27  LLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRN 86
           L+ + E++N LD E+RTPLH AA++GD  I++LL++SGA VNAKD +WLTPLHRA ASR+
Sbjct: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61

Query: 87  EKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHH 146
           E+ + +L+ HSADVNARDK WQTPLHVAAAN+A KCAE + PLLSS+NV+DR GR+ALHH
Sbjct: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121

Query: 147 AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKG 206
           A  +GH+E VNLLL KGA++N  DKK+R+ LHWAA++GHL+V+ LL+  GA++ CKD+KG
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181

Query: 207 YGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266
           Y  LH AA++GQI VVK+LL +G EIDE N +GNTALHIACY GQDAV  EL++ GANVN
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241

Query: 267 QPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI 326
           QPN+ GFTPLH AA ST+GALCLELLVNNGADVN QSK+GKSPLHM A+HGRFTRSQ LI
Sbjct: 242 QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI 301

Query: 327 QNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSD 386
           QNG EIDC DK GNTPLHVAARYGHELLI+TL T+GADTA+ GIH MFPLHLA L   SD
Sbjct: 302 QNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSD 361

Query: 387 CCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSG 446
           CCRKLLSS                  GF+I+TPD  GRTCLHAAA+GGNVEC+ LL SSG
Sbjct: 362 CCRKLLSS------------------GFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSG 403

Query: 447 ADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE 506
           AD  ++DK GRTPLHYAAAN  + C  TLVT GA VNE D  G + LHYAAASD  R   
Sbjct: 404 ADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKT 463

Query: 507 PHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNL 566
               +  ++EE E  +E + KEA  CLEFLL N A+PS+RD++GY ++HYAAAYG+RQ L
Sbjct: 464 ILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCL 523

Query: 567 ELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLAT 626
           ELLLE + +  E+ +S    SPLHLAAYNGH +AL+ L ++LV+LD+RD KGRTAL LA 
Sbjct: 524 ELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAA 583

Query: 627 ERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDA 686
            +G TECVE L   GAS  +K+   K TPLHA+  +GHT  L LL++  +  +  DV DA
Sbjct: 584 FKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDA 643

Query: 687 YGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAF 746
            GQTPLMLA+  GH+D V LLLEK +  D  D+ G TALHRG +TG E+C+  LL+ +  
Sbjct: 644 KGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS 703

Query: 747 VLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDC 806
           +LC+D +GRTP+H A+A GH   L  LLQ ALS +      D  GY+P+HWA Y G+E+C
Sbjct: 704 ILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDC-CFKDNQGYTPLHWACYNGNENC 762

Query: 807 LELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAA 866
           +E+LLE   F    GNPFTPLHCA+IN+  +   +LLGA+ + IV+ RD KGRTPL AAA
Sbjct: 763 IEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAA 822

Query: 867 FADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKN 926
           FAD+V  L++LL+H A VNA D++G+TALM AAENGQ  AV+ L+   +ADLTV D++ N
Sbjct: 823 FADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLN 882

Query: 927 TALHLACSKGHEKCALMILAETQDLGLINATNSALQ 962
           T LHLACSKGHEKCAL+IL + QD  LIN  N+ALQ
Sbjct: 883 TPLHLACSKGHEKCALLILDKIQDESLINEKNNALQ 918



 Score =  332 bits (851), Expect = 1e-90
 Identities = 274/908 (30%), Positives = 423/908 (46%), Gaps = 70/908 (7%)

Query: 158  LLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASG 217
            +L++K   +N  D ++R PLH AAFLG  E+++LL+  GA +  KD      LH A AS 
Sbjct: 1    MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 218  QIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLH 277
              E V+ L++  A+++  +    T LH+A        A  ++   ++VN  +  G T LH
Sbjct: 61   SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 278  VAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADK 337
             AA++ +  + + LL+  GA++N   K+ +  LH AA  G      +LI +G+E+ C DK
Sbjct: 121  HAALNGHVEM-VNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179

Query: 338  FGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQL 397
             G TPLH AA  G   ++  L+  G +     ++    LH+A                  
Sbjct: 180  KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIAC----------------- 222

Query: 398  YSIVSSLSNEHVLSAGFDINTPDNLGRTCLH-AAASGGNVECLNLLLSSGADLRRRDKFG 456
            Y+   ++ NE ++  G ++N P+N G T LH AAAS     CL LL+++GAD+  + K G
Sbjct: 223  YNGQDAVVNE-LIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDG 281

Query: 457  RTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAAS------DTYRRAEPHTP 510
            ++PLH  A +G +  + TL+  G  ++  D  G +PLH AA        +T R +   T 
Sbjct: 282  KSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTA 341

Query: 511  SSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLL 570
                     PL  +       C   LL +G +    D+ G T +H AAA GN + ++LL 
Sbjct: 342  KC-GIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQ 400

Query: 571  EMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLAT---- 626
                +  +  +     +PLH AA N H   ++TL  T  N++  D  GRTAL  A     
Sbjct: 401  SSGADFHK--KDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDM 458

Query: 627  ------------------------ERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS 662
                                    E+ +T C+E L  + A+  I++ K  +  +H AAA 
Sbjct: 459  DRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRD-KEGYNSIHYAAAY 517

Query: 663  GHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGR 722
            GH   L LL++    +   +      ++PL LA  NGH   + +LL+     D  D +GR
Sbjct: 518  GHRQCLELLLER-TNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGR 576

Query: 723  TALHRGAVTGCEDCLAALLDHDAFVLCRD-FKGRTPIHLASACGHTAVLRTLLQAALSTD 781
            TAL   A  G  +C+ AL++  A +  +D    RTP+H +   GHT  LR LL+ A + +
Sbjct: 577  TALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPE 636

Query: 782  PLDAGVDYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCAVINNQDSTTE 840
             +D   D  G +P+  A   GH D + LLLE  +    ++    T LH  ++   +   +
Sbjct: 637  AVDVK-DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQ 695

Query: 841  MLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQ---HQAEVNATDHTGRTALMT 897
            MLL    +  +  +D++GRTPLH AA   + + L  LLQ    + +    D+ G T L  
Sbjct: 696  MLLEQEVS--ILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHW 753

Query: 898  AAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINAT 957
            A  NG    +E LL +      +   N  T LH A    H  CA ++L    D  +++  
Sbjct: 754  ACYNGNENCIEVLLEQKCFRKFI--GNPFTPLHCAIINDHGNCASLLLGAI-DSSIVSCR 810

Query: 958  NSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILST 1017
            +   + PL  AA       +Q LL H A V AVD  G T  +  A N        L+ S 
Sbjct: 811  DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870

Query: 1018 MKPFPPKD 1025
                  KD
Sbjct: 871  QADLTVKD 878



 Score =  318 bits (814), Expect = 2e-86
 Identities = 269/849 (31%), Positives = 402/849 (47%), Gaps = 44/849 (5%)

Query: 9   QPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVN 68
           Q PL  A  ++ V+    ++    ++NV D+  RT LH AA  G V ++ LLL  GAN+N
Sbjct: 83  QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANIN 142

Query: 69  AKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128
           A D      LH AA   +  V+ LL+ H A+V  +DK   TPLH AA+N      + L  
Sbjct: 143 AFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLN 202

Query: 129 LLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEV 188
           L   ++  +  G +ALH A ++G    VN L++ GA++N  +     PLH+AA   H  +
Sbjct: 203 LGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGAL 262

Query: 189 -LKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIAC 247
            L+LLV  GAD+  + + G   LH  A  G+    + L++ G EID  +  GNT LH+A 
Sbjct: 263 CLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAA 322

Query: 248 YLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGK 307
             G + +   L  +GA+  +       PLH+AA++ +   C +LL ++G +++   K G+
Sbjct: 323 RYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLL-SSGFEIDTPDKFGR 381

Query: 308 SPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTAR 367
           + LH AA  G     ++L  +G++    DK G TPLH AA   H   I TL+T GA+   
Sbjct: 382 TCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNE 441

Query: 368 RGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCL 427
                   LH A     SD  R                N+ +L    D +      R   
Sbjct: 442 TDDWGRTALHYAAA---SDMDR----------------NKTILGNAHDNSEELERARELK 482

Query: 428 HAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQC-AVTLVTAGAGVNEAD 486
              A+     CL  LL + A+   RDK G   +HYAAA G  QC  + L    +G  E+D
Sbjct: 483 EKEAT----LCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESD 538

Query: 487 CKGC-SPLHYAAASDTYRRAEPHTPSSHDAE-EDEPLKESRRKEAF----FCLEFLLDNG 540
                SPLH AA +  ++  E    S  D +  DE  + +    AF     C+E L++ G
Sbjct: 539 SGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPG 598

Query: 541 ADPSLRDR-QGYTAVHYAAAYGNRQNLELLLEMSFNC-LEDVESTIPVSPLHLAAYNGHC 598
           A   ++D     T +H +   G+   L LLLE++ N    DV+     +PL LA   GH 
Sbjct: 599 ASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHI 658

Query: 599 EALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHA 658
           +A+  L E   N+D  D  G TAL      G  ECV++L     S L K+ + + TPLH 
Sbjct: 659 DAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGR-TPLHY 717

Query: 659 AAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAAD 718
           AAA GH   L  L+      +     D  G TPL  A  NG+ +C+ +LLE+        
Sbjct: 718 AAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG 777

Query: 719 LRGRTALHRGAVTGCEDCLAALLD--HDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQA 776
               T LH   +    +C + LL     + V CRD KGRTP+  A+   H   L+ LL+ 
Sbjct: 778 -NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLR- 835

Query: 777 ALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE--HSPFSYLEGNPFTPLHCAVINN 834
              + P++A VD SG + +  A+  G    +++L+    +  +  + +  TPLH A    
Sbjct: 836 --HSAPVNA-VDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKG 892

Query: 835 QDSTTEMLL 843
            +    ++L
Sbjct: 893 HEKCALLIL 901



 Score =  263 bits (672), Expect = 7e-70
 Identities = 229/802 (28%), Positives = 336/802 (41%), Gaps = 145/802 (18%)

Query: 8   DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAA------------------ 49
           D+  L  A +   ++ V  L++    +   D++  TPLHAAA                  
Sbjct: 148 DRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEI 207

Query: 50  ---------------YVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKV-LGLL 93
                          Y G   ++  L+  GANVN  +    TPLH AAAS +  + L LL
Sbjct: 208 DEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELL 267

Query: 94  LAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHL 153
           + + ADVN + K  ++PLH+ A +     ++ L      ++  D+ G + LH A   GH 
Sbjct: 268 VNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHE 327

Query: 154 ETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTA 213
             +N L   GA    C      PLH AA   H +  + L++ G ++   D+ G   LH A
Sbjct: 328 LLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAA 387

Query: 214 AASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGF 273
           AA G +E +K L   GA+  + +  G T LH A           LV  GANVN+ +D G 
Sbjct: 388 AAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGR 447

Query: 274 TPLHVAAVS---------------------------TNGALCLELLVNNGADVNYQSKEG 306
           T LH AA S                               LCLE L+ N A+ + + KEG
Sbjct: 448 TALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEG 507

Query: 307 -----------------------------------KSPLHMAAIHGRFTRSQILIQNGSE 331
                                              KSPLH+AA +G     ++L+Q+  +
Sbjct: 508 YNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVD 567

Query: 332 IDCADKFGNTPLHVAARYGHELLISTLMTNGADT-ARRGIHDMFPLHLAVLFGFSDCCRK 390
           +D  D+ G T L +AA  GH   +  L+  GA    +  +    PLH +V+ G + C R 
Sbjct: 568 LDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRL 627

Query: 391 LLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLR 450
           LL                +      ++  D  G+T L  A + G+++ ++LLL   A++ 
Sbjct: 628 LL---------------EIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVD 672

Query: 451 RRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTP 510
             D  G T LH     G  +C   L+     +   D +G +PLHYAAA            
Sbjct: 673 TVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAA------------ 720

Query: 511 SSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLL 570
             H     E L+ +  +E             D   +D QGYT +H+A   GN   +E+LL
Sbjct: 721 RGHATWLSELLQMALSEE-------------DCCFKDNQGYTPLHWACYNGNENCIEVLL 767

Query: 571 EMSFNCLEDVESTIPVSPLHLAAYN--GHCEALKTLAETLVNLDVRDHKGRTALFLATER 628
           E    C        P +PLH A  N  G+C +L   A     +  RD KGRT L  A   
Sbjct: 768 EQ--KCFRKFIGN-PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFA 824

Query: 629 GSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYG 688
              EC+++L  H A     +   K T L  AA +G   ++ +L++S + AD+T V D   
Sbjct: 825 DHVECLQLLLRHSAPVNAVDNSGK-TALMMAAENGQAGAVDILVNSAQ-ADLT-VKDKDL 881

Query: 689 QTPLMLAIMNGHVDCVHLLLEK 710
            TPL LA   GH  C  L+L+K
Sbjct: 882 NTPLHLACSKGHEKCALLILDK 903


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  293 bits (751), Expect = 5e-79
 Identities = 262/848 (30%), Positives = 378/848 (44%), Gaps = 86/848 (10%)

Query: 147 AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKG 206
           A  +G+L+ V   L  G  +N C++     LH AA  GH+ +++ L+ RG+ +    +KG
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76

Query: 207 YGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266
              LH A+ +GQ EVVK L++ GA I+  +  G T L++A       V   L+  GAN +
Sbjct: 77  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136

Query: 267 QPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI 326
              + GFTPL VA    +      LL N     + + K     LH+AA       + +L+
Sbjct: 137 TATEDGFTPLAVALQQGHNQAVAILLEN-----DTKGKVRLPALHIAARKDDTKSAALLL 191

Query: 327 QNGSEIDCADKF--------GNTPLHVAARYGHELLISTLMTNGAD---TARRGIHDMFP 375
           QN    D   K         G TPLH+AA YG+  + + L+  GA    TAR GI    P
Sbjct: 192 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI---TP 248

Query: 376 LHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGN 435
           LH+A   G ++  + LL  G                   D  T D  G T LH AA  G+
Sbjct: 249 LHVASKRGNTNMVKLLLDRG----------------GQIDAKTRD--GLTPLHCAARSGH 290

Query: 436 VECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHY 495
            + + LLL  GA L  R K G +PLH AA     +C   L+   A V++      + LH 
Sbjct: 291 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 350

Query: 496 AAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVH 555
           AA    YR                              + LLD  A+P+ R   G+T +H
Sbjct: 351 AAHCGHYR----------------------------VTKLLLDKRANPNARALNGFTPLH 382

Query: 556 YAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRD 615
            A      + +ELL++   +     ES +  +P+H+AA+ GH   +  L +   + DV +
Sbjct: 383 IACKKNRIKVMELLVKYGASIQAITESGL--TPIHVAAFMGHLNIVLLLLQNGASPDVTN 440

Query: 616 HKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSG 675
            +G TAL +A   G  E V  L  +GA    + R+ + TPLH A+  G T+ + LL+   
Sbjct: 441 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ-TPLHIASRLGKTEIVQLLL--- 496

Query: 676 ERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCED 735
           +     D     G TPL ++   G VD   +LLE G+    A  +G T LH  A  G  D
Sbjct: 497 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 556

Query: 736 CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPM 795
               LL   A        G TP+H+A+   +  V   LL+   S          +GY+P+
Sbjct: 557 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH----ATAKNGYTPL 612

Query: 796 HWASYTGHEDCLELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTTEM--LLGALGAKIVN 852
           H A+          LL + +  + +     TPLH A   +Q+  T+M  LL   GA I  
Sbjct: 613 HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA---SQEGHTDMVTLLLDKGANIHM 669

Query: 853 SRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLY 912
           S  + G T LH AA  D V+   +L +H A+ +A    G T L+ A   G    V FLL 
Sbjct: 670 STKS-GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK 728

Query: 913 RGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNG 972
           +G A++    +N  T LH A  +GH     ++L   Q     NAT +     L IA R G
Sbjct: 729 QG-ANVNAKTKNGYTPLHQAAQQGHTHIINVLL---QHGAKPNATTANGNTALAIAKRLG 784

Query: 973 LASVVQAL 980
             SVV  L
Sbjct: 785 YISVVDTL 792



 Score =  283 bits (725), Expect = 5e-76
 Identities = 250/840 (29%), Positives = 362/840 (43%), Gaps = 72/840 (8%)

Query: 80  RAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS 139
           RAA + N   +   L    D+N  ++     LH+AA        + L    SS++ A + 
Sbjct: 16  RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 75

Query: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199
           G +ALH A  +G  E V +L+ +GA++N   +    PL+ AA   H++V+K L+  GA+ 
Sbjct: 76  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 135

Query: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV 259
                 G+  L  A   G  + V  LL    E D        ALHIA        A  L+
Sbjct: 136 STATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLL 191

Query: 260 NAGAN--------VNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLH 311
               N        VN+  + GFTPLH+AA   N  +   LL+N GA V++ ++ G +PLH
Sbjct: 192 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPLH 250

Query: 312 MAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIH 371
           +A+  G     ++L+  G +ID   + G TPLH AAR GH+ ++  L+  GA    R  +
Sbjct: 251 VASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 310

Query: 372 DMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAA 431
            + PLH+A      +C + LL                   A  D  T D L  T LH AA
Sbjct: 311 GLSPLHMAAQGDHVECVKHLLQH----------------KAPVDDVTLDYL--TALHVAA 352

Query: 432 SGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCS 491
             G+     LLL   A+   R   G TPLH A      +    LV  GA +      G +
Sbjct: 353 HCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLT 412

Query: 492 PLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGY 551
           P+H AA                                   +  LL NGA P + + +G 
Sbjct: 413 PIHVAAFMGHLN----------------------------IVLLLLQNGASPDVTNIRGE 444

Query: 552 TAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNL 611
           TA+H AA  G  + +  LL      L D  +    +PLH+A+  G  E ++ L + + + 
Sbjct: 445 TALHMAARAGQVEVVRCLLRN--GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 502

Query: 612 DVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLL 671
           D     G T L ++   G  +   VL   GA+  +   K+ +TPLH AA  G  D   LL
Sbjct: 503 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL-ATKKGFTPLHVAAKYGSLDVAKLL 561

Query: 672 IDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVT 731
           +   +R    D     G TPL +A    +     LLLEKG++  A    G T LH  A  
Sbjct: 562 L---QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 618

Query: 732 GCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSG 791
                 + LL++ A       +G TP+HLAS  GHT ++  LL    +          SG
Sbjct: 619 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK----SG 674

Query: 792 YSPMHWASYTGHEDCLELLLEHSPFSYLEGN-PFTPLHCAVINNQDSTTEMLLGALGAKI 850
            + +H A+     +  ++L +H           +TPL  A           LL   GA  
Sbjct: 675 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL-KQGAN- 732

Query: 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910
           VN++   G TPLH AA   +   + +LLQH A+ NAT   G TAL  A   G  + V+ L
Sbjct: 733 VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792



 Score =  268 bits (686), Expect = 2e-71
 Identities = 241/821 (29%), Positives = 373/821 (45%), Gaps = 88/821 (10%)

Query: 213  AAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272
            AA +G ++ V   L+ G +I+  N  G  ALH+A   G   +  EL+  G++V+    KG
Sbjct: 17   AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76

Query: 273  FTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEI 332
             T LH+A+++    + +++LV  GA++N QS+ G +PL+MAA        + L++NG+  
Sbjct: 77   NTALHIASLAGQAEV-VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 135

Query: 333  DCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLL 392
              A + G TPL VA + GH   ++ L+ N  DT  +G   +  LH+A     +     LL
Sbjct: 136  STATEDGFTPLAVALQQGHNQAVAILLEN--DT--KGKVRLPALHIAARKDDTKSAALLL 191

Query: 393  SSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRR 452
             +     + S +       +GF          T LH AA  GNV    LLL+ GA +   
Sbjct: 192  QNDHNADVQSKMMVNRTTESGF----------TPLHIAAHYGNVNVATLLLNRGAAVDFT 241

Query: 453  DKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSS 512
             + G TPLH A+  G+      L+  G  ++     G +PLH AA S             
Sbjct: 242  ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS------------G 289

Query: 513  HDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEM 572
            HD                  +E LL+ GA    R + G + +H AA   + + ++ LL+ 
Sbjct: 290  HDQ----------------VVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333

Query: 573  SFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTE 632
                ++DV     ++ LH+AA+ GH    K L +   N + R   G T L +A ++   +
Sbjct: 334  KAP-VDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK 391

Query: 633  CVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDV--------- 683
             +E+L  +GAS +    +   TP+H AA  GH + + LL+ +G   D+T++         
Sbjct: 392  VMELLVKYGAS-IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 450

Query: 684  ------------------MDAYG---QTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGR 722
                              +DA     QTPL +A   G  + V LLL+  +  DAA   G 
Sbjct: 451  ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 510

Query: 723  TALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDP 782
            T LH  A  G  D  + LL+  A       KG TP+H+A+  G   V + LLQ   + D 
Sbjct: 511  TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD- 569

Query: 783  LDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEG-NPFTPLHCAVINNQDSTTEM 841
                   +G +P+H A++  ++    LLLE     +    N +TPLH A   NQ      
Sbjct: 570  ---SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAST 626

Query: 842  LLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAEN 901
            LL   GA+  N    +G TPLH A+   +   + +LL   A ++ +  +G T+L  AA+ 
Sbjct: 627  LLN-YGAE-TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 684

Query: 902  GQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSAL 961
             +    + L   G AD     +   T L +AC  G+ K    +L +  +   +NA     
Sbjct: 685  DKVNVADILTKHG-ADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN---VNAKTKNG 740

Query: 962  QMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002
              PLH AA+ G   ++  LL HGA   A    G+T ALA A
Sbjct: 741  YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNT-ALAIA 780



 Score =  243 bits (621), Expect = 5e-64
 Identities = 220/797 (27%), Positives = 336/797 (42%), Gaps = 118/797 (14%)

Query: 13  VQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDT 72
           ++A  + ++++V   L    +IN  +Q     LH AA  G V ++Q LL  G++V++   
Sbjct: 15  LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 74

Query: 73  LWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSS 132
              T LH A+ +   +V+ +L+   A++NA+ +   TPL++AA        + L    ++
Sbjct: 75  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134

Query: 133 LNVADRSGRSALHHAVHSGHLETVNLLL---NKG----ASLNVCDKKER----------- 174
            + A   G + L  A+  GH + V +LL    KG     +L++  +K+            
Sbjct: 135 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 194

Query: 175 -------------------QPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAA 215
                               PLH AA  G++ V  LL+ RGA +    R G   LH A+ 
Sbjct: 195 HNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK 254

Query: 216 SGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTP 275
            G   +VK LL  G +ID     G T LH A   G D V   L+  GA +      G +P
Sbjct: 255 RGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 314

Query: 276 LHVAAVSTN---------------------------GALC-----LELLVNNGADVNYQS 303
           LH+AA   +                            A C      +LL++  A+ N ++
Sbjct: 315 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 374

Query: 304 KEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGA 363
             G +PLH+A    R    ++L++ G+ I    + G TP+HVAA  GH  ++  L+ NGA
Sbjct: 375 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 434

Query: 364 DTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYS-----------IVSSLSNEHVLSA 412
                 I     LH+A   G  +  R LL +G L             I S L    ++  
Sbjct: 435 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 494

Query: 413 GFD-INTPD---NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468
               +  PD     G T LH +A  G V+  ++LL +GA      K G TPLH AA  GS
Sbjct: 495 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 554

Query: 469 YQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKE 528
              A  L+   A  + A   G +PLH AA  D  + A                       
Sbjct: 555 LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVA----------------------- 591

Query: 529 AFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSP 588
                  LL+ GA P    + GYT +H AA     Q    LL  ++    ++ +   V+P
Sbjct: 592 -----LLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL--NYGAETNIVTKQGVTP 644

Query: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
           LHLA+  GH + +  L +   N+ +    G T+L LA +       ++LT HGA      
Sbjct: 645 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ-DAH 703

Query: 649 RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL 708
            K  +TPL  A   G+   ++ L+  G      +     G TPL  A   GH   +++LL
Sbjct: 704 TKLGYTPLIVACHYGNVKMVNFLLKQGAN---VNAKTKNGYTPLHQAAQQGHTHIINVLL 760

Query: 709 EKGSTADAADLRGRTAL 725
           + G+  +A    G TAL
Sbjct: 761 QHGAKPNATTANGNTAL 777



 Score =  232 bits (591), Expect = 2e-60
 Identities = 209/750 (27%), Positives = 325/750 (43%), Gaps = 90/750 (12%)

Query: 302  QSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTN 361
            Q  +  +    AA  G   +    ++ G +I+  ++ G   LH+AA+ GH  L+  L+  
Sbjct: 6    QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65

Query: 362  GADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDN 421
            G+            LH+A L G ++  + L+  G                   +IN    
Sbjct: 66   GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA------------------NINAQSQ 107

Query: 422  LGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAG 481
             G T L+ AA   +++ +  LL +GA+     + G TPL  A   G  Q    L+     
Sbjct: 108  NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL----- 162

Query: 482  VNEADCKG---CSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFF------- 531
              E D KG      LH AA  D  + A     + H+A+    +  +R  E+ F       
Sbjct: 163  --ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 220

Query: 532  ------CLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIP 585
                      LL+ GA      R G T +H A+  GN   ++LLL+       D ++   
Sbjct: 221  HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI--DAKTRDG 278

Query: 586  VSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGA--- 642
            ++PLH AA +GH + ++ L E    L  R   G + L +A +    ECV+ L  H A   
Sbjct: 279  LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 338

Query: 643  ---------------------SALIKERKRK--------WTPLHAAAASGHTDSLHLLID 673
                                 + L+ +++          +TPLH A        + LL+ 
Sbjct: 339  DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK 398

Query: 674  SGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGC 733
             G  A I  + ++ G TP+ +A   GH++ V LLL+ G++ D  ++RG TALH  A  G 
Sbjct: 399  YG--ASIQAITES-GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQ 455

Query: 734  EDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYS 793
             + +  LL + A V  R  + +TP+H+AS  G T +++ LLQ     D        +GY+
Sbjct: 456  VEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD----AATTNGYT 511

Query: 794  PMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVN 852
            P+H ++  G  D   +LLE  +  S      FTPLH A         ++LL    A   +
Sbjct: 512  PLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA--AD 569

Query: 853  SRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLY 912
            S    G TPLH AA  DN     +LL+  A  +AT   G T L  AA+  Q      LL 
Sbjct: 570  SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 629

Query: 913  RGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNG 972
             G A+  ++ +   T LHLA  +GH     ++L +  ++ +  +T S L   LH+AA+  
Sbjct: 630  YG-AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM--STKSGL-TSLHLAAQED 685

Query: 973  LASVVQALLSHGATVLAVDEEGHTPAL-AC 1001
              +V   L  HGA   A  + G+TP + AC
Sbjct: 686  KVNVADILTKHGADQDAHTKLGYTPLIVAC 715



 Score =  223 bits (569), Expect = 6e-58
 Identities = 182/599 (30%), Positives = 271/599 (45%), Gaps = 77/599 (12%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           PL  A    +V     LL++   ++   +   TPLH A+  G+  +++LLL  G  ++AK
Sbjct: 215 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 274

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
               LTPLH AA S +++V+ LLL   A + AR K   +PLH+AA     +C + L    
Sbjct: 275 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 334

Query: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGAS-----------LNVCDKKER----- 174
           + ++       +ALH A H GH     LLL+K A+           L++  KK R     
Sbjct: 335 APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVME 394

Query: 175 -----------------QPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASG 217
                             P+H AAF+GHL ++ LL+  GA     + +G   LH AA +G
Sbjct: 395 LLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG 454

Query: 218 QIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLH 277
           Q+EVV+ LLR GA +D       T LHIA  LG+  +   L+   A+ +     G+TPLH
Sbjct: 455 QVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 514

Query: 278 VAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADK 337
           ++A      +   +L+  GA  +  +K+G +PLH+AA +G    +++L+Q  +  D A K
Sbjct: 515 ISAREGQVDVA-SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK 573

Query: 338 FGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQL 397
            G TPLHVAA Y ++ +   L+  GA       +   PLH+A           LL+ G  
Sbjct: 574 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 633

Query: 398 YSIVSS-------LSNEH--------VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLL 442
            +IV+        L+++         +L  G +I+     G T LH AA    V   ++L
Sbjct: 634 TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 693

Query: 443 LSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTY 502
              GAD     K G TPL  A   G+ +    L+  GA VN     G +PLH AA     
Sbjct: 694 TKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA----- 748

Query: 503 RRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYG 561
              + HT                       +  LL +GA P+     G TA+  A   G
Sbjct: 749 --QQGHT---------------------HIINVLLQHGAKPNATTANGNTALAIAKRLG 784



 Score =  179 bits (455), Expect = 1e-44
 Identities = 172/625 (27%), Positives = 266/625 (42%), Gaps = 61/625 (9%)

Query: 463  AAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLK 522
            AA  G+    V  +  G  +N  +  G + LH AA        E H              
Sbjct: 17   AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAK-------EGHVG------------ 57

Query: 523  ESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVES 582
                      ++ LL  G+      ++G TA+H A+  G  + +++L++   N   + +S
Sbjct: 58   ---------LVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI--NAQS 106

Query: 583  TIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGA 642
                +PL++AA   H + +K L E   N       G T L +A ++G  + V +L  +  
Sbjct: 107  QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 166

Query: 643  SALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVM-----DAYGQTPLMLAIM 697
                   K +   LH AA    T S  LL+ +   AD+   M        G TPL +A  
Sbjct: 167  KG-----KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 221

Query: 698  NGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTP 757
             G+V+   LLL +G+  D     G T LH  +  G  + +  LLD    +  +   G TP
Sbjct: 222  YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 281

Query: 758  IHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPF 816
            +H A+  GH  V+  LL+      PL A    +G SP+H A+   H +C++ LL+H +P 
Sbjct: 282  LHCAARSGHDQVVELLLERGA---PLLARTK-NGLSPLHMAAQGDHVECVKHLLQHKAPV 337

Query: 817  SYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRM 876
              +  +  T LH A        T++LL        N+R   G TPLH A   + +  + +
Sbjct: 338  DDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP--NARALNGFTPLHIACKKNRIKVMEL 395

Query: 877  LLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKG 936
            L+++ A + A   +G T +  AA  G    V  LL  G A   V +    TALH+A   G
Sbjct: 396  LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAG 454

Query: 937  HEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHT 996
              +    +L   ++  L++A     Q PLHIA+R G   +VQ LL H A   A    G+T
Sbjct: 455  QVEVVRCLL---RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT 511

Query: 997  PALACA--PNKDVADCL-----ALILSTMKPFPPKDAVSPFSFSLLKNCSI---AAAKTV 1046
            P    A     DVA  L     A  L+T K F P    + +    +    +   AAA + 
Sbjct: 512  PLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSA 571

Query: 1047 GGCGALPHGASCPYSQERPGAIGLD 1071
            G  G  P   +  Y  ++   + L+
Sbjct: 572  GKNGLTPLHVAAHYDNQKVALLLLE 596



 Score =  166 bits (419), Expect = 1e-40
 Identities = 118/356 (33%), Positives = 178/356 (50%), Gaps = 1/356 (0%)

Query: 3   ILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLM 62
           + +I  +  L  A  +  VE VR LL     ++   +E +TPLH A+ +G   I+QLLL 
Sbjct: 438 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 497

Query: 63  SGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKC 122
             A+ +A  T   TPLH +A      V  +LL   A  +   K   TPLHVAA   +   
Sbjct: 498 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 557

Query: 123 AEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAF 182
           A+ L    ++ + A ++G + LH A H  + +   LLL KGAS +   K    PLH AA 
Sbjct: 558 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 617

Query: 183 LGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTA 242
              +++   L+  GA+     ++G   LH A+  G  ++V  LL  GA I      G T+
Sbjct: 618 KNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS 677

Query: 243 LHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQ 302
           LH+A    +  VA  L   GA+ +     G+TPL VA    N  + +  L+  GA+VN +
Sbjct: 678 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM-VNFLLKQGANVNAK 736

Query: 303 SKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
           +K G +PLH AA  G      +L+Q+G++ +     GNT L +A R G+  ++ TL
Sbjct: 737 TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 61/190 (32%), Positives = 88/190 (46%)

Query: 43  TPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNA 102
           TPLH AA    + I   LL  GA  N      +TPLH A+   +  ++ LLL   A+++ 
Sbjct: 610 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 669

Query: 103 RDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNK 162
             K   T LH+AA       A+ L    +  +   + G + L  A H G+++ VN LL +
Sbjct: 670 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 729

Query: 163 GASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVV 222
           GA++N   K    PLH AA  GH  ++ +L+  GA        G   L  A   G I VV
Sbjct: 730 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 789

Query: 223 KYLLRMGAEI 232
             L  +  E+
Sbjct: 790 DTLKVVTEEV 799


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  293 bits (751), Expect = 5e-79
 Identities = 262/848 (30%), Positives = 378/848 (44%), Gaps = 86/848 (10%)

Query: 147 AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKG 206
           A  +G+L+ V   L  G  +N C++     LH AA  GH+ +++ L+ RG+ +    +KG
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 207 YGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266
              LH A+ +GQ EVVK L++ GA I+  +  G T L++A       V   L+  GAN +
Sbjct: 98  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157

Query: 267 QPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI 326
              + GFTPL VA    +      LL N     + + K     LH+AA       + +L+
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLEN-----DTKGKVRLPALHIAARKDDTKSAALLL 212

Query: 327 QNGSEIDCADKF--------GNTPLHVAARYGHELLISTLMTNGAD---TARRGIHDMFP 375
           QN    D   K         G TPLH+AA YG+  + + L+  GA    TAR GI    P
Sbjct: 213 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI---TP 269

Query: 376 LHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGN 435
           LH+A   G ++  + LL  G                   D  T D  G T LH AA  G+
Sbjct: 270 LHVASKRGNTNMVKLLLDRG----------------GQIDAKTRD--GLTPLHCAARSGH 311

Query: 436 VECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHY 495
            + + LLL  GA L  R K G +PLH AA     +C   L+   A V++      + LH 
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 371

Query: 496 AAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVH 555
           AA    YR                              + LLD  A+P+ R   G+T +H
Sbjct: 372 AAHCGHYR----------------------------VTKLLLDKRANPNARALNGFTPLH 403

Query: 556 YAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRD 615
            A      + +ELL++   +     ES +  +P+H+AA+ GH   +  L +   + DV +
Sbjct: 404 IACKKNRIKVMELLVKYGASIQAITESGL--TPIHVAAFMGHLNIVLLLLQNGASPDVTN 461

Query: 616 HKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSG 675
            +G TAL +A   G  E V  L  +GA    + R+ + TPLH A+  G T+ + LL+   
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ-TPLHIASRLGKTEIVQLLL--- 517

Query: 676 ERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCED 735
           +     D     G TPL ++   G VD   +LLE G+    A  +G T LH  A  G  D
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 577

Query: 736 CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPM 795
               LL   A        G TP+H+A+   +  V   LL+   S          +GY+P+
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH----ATAKNGYTPL 633

Query: 796 HWASYTGHEDCLELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTTEM--LLGALGAKIVN 852
           H A+          LL + +  + +     TPLH A   +Q+  T+M  LL   GA I  
Sbjct: 634 HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA---SQEGHTDMVTLLLDKGANIHM 690

Query: 853 SRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLY 912
           S  + G T LH AA  D V+   +L +H A+ +A    G T L+ A   G    V FLL 
Sbjct: 691 STKS-GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK 749

Query: 913 RGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNG 972
           +G A++    +N  T LH A  +GH     ++L   Q     NAT +     L IA R G
Sbjct: 750 QG-ANVNAKTKNGYTPLHQAAQQGHTHIINVLL---QHGAKPNATTANGNTALAIAKRLG 805

Query: 973 LASVVQAL 980
             SVV  L
Sbjct: 806 YISVVDTL 813



 Score =  283 bits (725), Expect = 5e-76
 Identities = 250/840 (29%), Positives = 362/840 (43%), Gaps = 72/840 (8%)

Query: 80  RAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS 139
           RAA + N   +   L    D+N  ++     LH+AA        + L    SS++ A + 
Sbjct: 37  RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96

Query: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199
           G +ALH A  +G  E V +L+ +GA++N   +    PL+ AA   H++V+K L+  GA+ 
Sbjct: 97  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156

Query: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV 259
                 G+  L  A   G  + V  LL    E D        ALHIA        A  L+
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLL 212

Query: 260 NAGAN--------VNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLH 311
               N        VN+  + GFTPLH+AA   N  +   LL+N GA V++ ++ G +PLH
Sbjct: 213 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPLH 271

Query: 312 MAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIH 371
           +A+  G     ++L+  G +ID   + G TPLH AAR GH+ ++  L+  GA    R  +
Sbjct: 272 VASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331

Query: 372 DMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAA 431
            + PLH+A      +C + LL                   A  D  T D L  T LH AA
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQH----------------KAPVDDVTLDYL--TALHVAA 373

Query: 432 SGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCS 491
             G+     LLL   A+   R   G TPLH A      +    LV  GA +      G +
Sbjct: 374 HCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLT 433

Query: 492 PLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGY 551
           P+H AA                                   +  LL NGA P + + +G 
Sbjct: 434 PIHVAAFMGHLN----------------------------IVLLLLQNGASPDVTNIRGE 465

Query: 552 TAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNL 611
           TA+H AA  G  + +  LL      L D  +    +PLH+A+  G  E ++ L + + + 
Sbjct: 466 TALHMAARAGQVEVVRCLLRN--GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 523

Query: 612 DVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLL 671
           D     G T L ++   G  +   VL   GA+  +   K+ +TPLH AA  G  D   LL
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL-ATKKGFTPLHVAAKYGSLDVAKLL 582

Query: 672 IDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVT 731
           +   +R    D     G TPL +A    +     LLLEKG++  A    G T LH  A  
Sbjct: 583 L---QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 639

Query: 732 GCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSG 791
                 + LL++ A       +G TP+HLAS  GHT ++  LL    +          SG
Sbjct: 640 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK----SG 695

Query: 792 YSPMHWASYTGHEDCLELLLEHSPFSYLEGN-PFTPLHCAVINNQDSTTEMLLGALGAKI 850
            + +H A+     +  ++L +H           +TPL  A           LL   GA  
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL-KQGAN- 753

Query: 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910
           VN++   G TPLH AA   +   + +LLQH A+ NAT   G TAL  A   G  + V+ L
Sbjct: 754 VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score =  268 bits (686), Expect = 2e-71
 Identities = 241/821 (29%), Positives = 373/821 (45%), Gaps = 88/821 (10%)

Query: 213  AAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272
            AA +G ++ V   L+ G +I+  N  G  ALH+A   G   +  EL+  G++V+    KG
Sbjct: 38   AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 273  FTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEI 332
             T LH+A+++    + +++LV  GA++N QS+ G +PL+MAA        + L++NG+  
Sbjct: 98   NTALHIASLAGQAEV-VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156

Query: 333  DCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLL 392
              A + G TPL VA + GH   ++ L+ N  DT  +G   +  LH+A     +     LL
Sbjct: 157  STATEDGFTPLAVALQQGHNQAVAILLEN--DT--KGKVRLPALHIAARKDDTKSAALLL 212

Query: 393  SSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRR 452
             +     + S +       +GF          T LH AA  GNV    LLL+ GA +   
Sbjct: 213  QNDHNADVQSKMMVNRTTESGF----------TPLHIAAHYGNVNVATLLLNRGAAVDFT 262

Query: 453  DKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSS 512
             + G TPLH A+  G+      L+  G  ++     G +PLH AA S             
Sbjct: 263  ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS------------G 310

Query: 513  HDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEM 572
            HD                  +E LL+ GA    R + G + +H AA   + + ++ LL+ 
Sbjct: 311  HDQ----------------VVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354

Query: 573  SFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTE 632
                ++DV     ++ LH+AA+ GH    K L +   N + R   G T L +A ++   +
Sbjct: 355  KAP-VDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK 412

Query: 633  CVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDV--------- 683
             +E+L  +GAS +    +   TP+H AA  GH + + LL+ +G   D+T++         
Sbjct: 413  VMELLVKYGAS-IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471

Query: 684  ------------------MDAYG---QTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGR 722
                              +DA     QTPL +A   G  + V LLL+  +  DAA   G 
Sbjct: 472  ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 531

Query: 723  TALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDP 782
            T LH  A  G  D  + LL+  A       KG TP+H+A+  G   V + LLQ   + D 
Sbjct: 532  TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD- 590

Query: 783  LDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEG-NPFTPLHCAVINNQDSTTEM 841
                   +G +P+H A++  ++    LLLE     +    N +TPLH A   NQ      
Sbjct: 591  ---SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAST 647

Query: 842  LLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAEN 901
            LL   GA+  N    +G TPLH A+   +   + +LL   A ++ +  +G T+L  AA+ 
Sbjct: 648  LLN-YGAE-TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 705

Query: 902  GQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSAL 961
             +    + L   G AD     +   T L +AC  G+ K    +L +  +   +NA     
Sbjct: 706  DKVNVADILTKHG-ADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN---VNAKTKNG 761

Query: 962  QMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002
              PLH AA+ G   ++  LL HGA   A    G+T ALA A
Sbjct: 762  YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNT-ALAIA 801



 Score =  243 bits (621), Expect = 5e-64
 Identities = 220/797 (27%), Positives = 336/797 (42%), Gaps = 118/797 (14%)

Query: 13  VQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDT 72
           ++A  + ++++V   L    +IN  +Q     LH AA  G V ++Q LL  G++V++   
Sbjct: 36  LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95

Query: 73  LWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSS 132
              T LH A+ +   +V+ +L+   A++NA+ +   TPL++AA        + L    ++
Sbjct: 96  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155

Query: 133 LNVADRSGRSALHHAVHSGHLETVNLLL---NKG----ASLNVCDKKER----------- 174
            + A   G + L  A+  GH + V +LL    KG     +L++  +K+            
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 215

Query: 175 -------------------QPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAA 215
                               PLH AA  G++ V  LL+ RGA +    R G   LH A+ 
Sbjct: 216 HNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK 275

Query: 216 SGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTP 275
            G   +VK LL  G +ID     G T LH A   G D V   L+  GA +      G +P
Sbjct: 276 RGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 335

Query: 276 LHVAAVSTN---------------------------GALC-----LELLVNNGADVNYQS 303
           LH+AA   +                            A C      +LL++  A+ N ++
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395

Query: 304 KEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGA 363
             G +PLH+A    R    ++L++ G+ I    + G TP+HVAA  GH  ++  L+ NGA
Sbjct: 396 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455

Query: 364 DTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYS-----------IVSSLSNEHVLSA 412
                 I     LH+A   G  +  R LL +G L             I S L    ++  
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515

Query: 413 GFD-INTPD---NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468
               +  PD     G T LH +A  G V+  ++LL +GA      K G TPLH AA  GS
Sbjct: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575

Query: 469 YQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKE 528
              A  L+   A  + A   G +PLH AA  D  + A                       
Sbjct: 576 LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVA----------------------- 612

Query: 529 AFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSP 588
                  LL+ GA P    + GYT +H AA     Q    LL  ++    ++ +   V+P
Sbjct: 613 -----LLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL--NYGAETNIVTKQGVTP 665

Query: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
           LHLA+  GH + +  L +   N+ +    G T+L LA +       ++LT HGA      
Sbjct: 666 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ-DAH 724

Query: 649 RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL 708
            K  +TPL  A   G+   ++ L+  G      +     G TPL  A   GH   +++LL
Sbjct: 725 TKLGYTPLIVACHYGNVKMVNFLLKQGAN---VNAKTKNGYTPLHQAAQQGHTHIINVLL 781

Query: 709 EKGSTADAADLRGRTAL 725
           + G+  +A    G TAL
Sbjct: 782 QHGAKPNATTANGNTAL 798



 Score =  223 bits (569), Expect = 6e-58
 Identities = 182/599 (30%), Positives = 271/599 (45%), Gaps = 77/599 (12%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           PL  A    +V     LL++   ++   +   TPLH A+  G+  +++LLL  G  ++AK
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
               LTPLH AA S +++V+ LLL   A + AR K   +PLH+AA     +C + L    
Sbjct: 296 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355

Query: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGAS-----------LNVCDKKER----- 174
           + ++       +ALH A H GH     LLL+K A+           L++  KK R     
Sbjct: 356 APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVME 415

Query: 175 -----------------QPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASG 217
                             P+H AAF+GHL ++ LL+  GA     + +G   LH AA +G
Sbjct: 416 LLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG 475

Query: 218 QIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLH 277
           Q+EVV+ LLR GA +D       T LHIA  LG+  +   L+   A+ +     G+TPLH
Sbjct: 476 QVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535

Query: 278 VAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADK 337
           ++A      +   +L+  GA  +  +K+G +PLH+AA +G    +++L+Q  +  D A K
Sbjct: 536 ISAREGQVDVA-SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK 594

Query: 338 FGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQL 397
            G TPLHVAA Y ++ +   L+  GA       +   PLH+A           LL+ G  
Sbjct: 595 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 654

Query: 398 YSIVSS-------LSNEH--------VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLL 442
            +IV+        L+++         +L  G +I+     G T LH AA    V   ++L
Sbjct: 655 TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714

Query: 443 LSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTY 502
              GAD     K G TPL  A   G+ +    L+  GA VN     G +PLH AA     
Sbjct: 715 TKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA----- 769

Query: 503 RRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYG 561
              + HT                       +  LL +GA P+     G TA+  A   G
Sbjct: 770 --QQGHT---------------------HIINVLLQHGAKPNATTANGNTALAIAKRLG 805



 Score =  179 bits (455), Expect = 1e-44
 Identities = 172/625 (27%), Positives = 266/625 (42%), Gaps = 61/625 (9%)

Query: 463  AAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLK 522
            AA  G+    V  +  G  +N  +  G + LH AA        E H              
Sbjct: 38   AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAK-------EGHVG------------ 78

Query: 523  ESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVES 582
                      ++ LL  G+      ++G TA+H A+  G  + +++L++   N   + +S
Sbjct: 79   ---------LVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI--NAQS 127

Query: 583  TIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGA 642
                +PL++AA   H + +K L E   N       G T L +A ++G  + V +L  +  
Sbjct: 128  QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 187

Query: 643  SALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVM-----DAYGQTPLMLAIM 697
                   K +   LH AA    T S  LL+ +   AD+   M        G TPL +A  
Sbjct: 188  KG-----KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242

Query: 698  NGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTP 757
             G+V+   LLL +G+  D     G T LH  +  G  + +  LLD    +  +   G TP
Sbjct: 243  YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 302

Query: 758  IHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPF 816
            +H A+  GH  V+  LL+      PL A    +G SP+H A+   H +C++ LL+H +P 
Sbjct: 303  LHCAARSGHDQVVELLLERGA---PLLARTK-NGLSPLHMAAQGDHVECVKHLLQHKAPV 358

Query: 817  SYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRM 876
              +  +  T LH A        T++LL        N+R   G TPLH A   + +  + +
Sbjct: 359  DDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP--NARALNGFTPLHIACKKNRIKVMEL 416

Query: 877  LLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKG 936
            L+++ A + A   +G T +  AA  G    V  LL  G A   V +    TALH+A   G
Sbjct: 417  LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAG 475

Query: 937  HEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHT 996
              +    +L   ++  L++A     Q PLHIA+R G   +VQ LL H A   A    G+T
Sbjct: 476  QVEVVRCLL---RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT 532

Query: 997  PALACA--PNKDVADCL-----ALILSTMKPFPPKDAVSPFSFSLLKNCSI---AAAKTV 1046
            P    A     DVA  L     A  L+T K F P    + +    +    +   AAA + 
Sbjct: 533  PLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSA 592

Query: 1047 GGCGALPHGASCPYSQERPGAIGLD 1071
            G  G  P   +  Y  ++   + L+
Sbjct: 593  GKNGLTPLHVAAHYDNQKVALLLLE 617



 Score =  166 bits (419), Expect = 1e-40
 Identities = 118/356 (33%), Positives = 178/356 (50%), Gaps = 1/356 (0%)

Query: 3   ILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLM 62
           + +I  +  L  A  +  VE VR LL     ++   +E +TPLH A+ +G   I+QLLL 
Sbjct: 459 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518

Query: 63  SGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKC 122
             A+ +A  T   TPLH +A      V  +LL   A  +   K   TPLHVAA   +   
Sbjct: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578

Query: 123 AEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAF 182
           A+ L    ++ + A ++G + LH A H  + +   LLL KGAS +   K    PLH AA 
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638

Query: 183 LGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTA 242
              +++   L+  GA+     ++G   LH A+  G  ++V  LL  GA I      G T+
Sbjct: 639 KNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS 698

Query: 243 LHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQ 302
           LH+A    +  VA  L   GA+ +     G+TPL VA    N  + +  L+  GA+VN +
Sbjct: 699 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM-VNFLLKQGANVNAK 757

Query: 303 SKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
           +K G +PLH AA  G      +L+Q+G++ +     GNT L +A R G+  ++ TL
Sbjct: 758 TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 61/190 (32%), Positives = 88/190 (46%)

Query: 43  TPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNA 102
           TPLH AA    + I   LL  GA  N      +TPLH A+   +  ++ LLL   A+++ 
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 690

Query: 103 RDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNK 162
             K   T LH+AA       A+ L    +  +   + G + L  A H G+++ VN LL +
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750

Query: 163 GASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVV 222
           GA++N   K    PLH AA  GH  ++ +L+  GA        G   L  A   G I VV
Sbjct: 751 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810

Query: 223 KYLLRMGAEI 232
             L  +  E+
Sbjct: 811 DTLKVVTEEV 820


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  293 bits (751), Expect = 5e-79
 Identities = 262/848 (30%), Positives = 378/848 (44%), Gaps = 86/848 (10%)

Query: 147 AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKG 206
           A  +G+L+ V   L  G  +N C++     LH AA  GH+ +++ L+ RG+ +    +KG
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 207 YGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266
              LH A+ +GQ EVVK L++ GA I+  +  G T L++A       V   L+  GAN +
Sbjct: 98  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157

Query: 267 QPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI 326
              + GFTPL VA    +      LL N     + + K     LH+AA       + +L+
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLEN-----DTKGKVRLPALHIAARKDDTKSAALLL 212

Query: 327 QNGSEIDCADKF--------GNTPLHVAARYGHELLISTLMTNGAD---TARRGIHDMFP 375
           QN    D   K         G TPLH+AA YG+  + + L+  GA    TAR GI    P
Sbjct: 213 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI---TP 269

Query: 376 LHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGN 435
           LH+A   G ++  + LL  G                   D  T D  G T LH AA  G+
Sbjct: 270 LHVASKRGNTNMVKLLLDRG----------------GQIDAKTRD--GLTPLHCAARSGH 311

Query: 436 VECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHY 495
            + + LLL  GA L  R K G +PLH AA     +C   L+   A V++      + LH 
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 371

Query: 496 AAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVH 555
           AA    YR                              + LLD  A+P+ R   G+T +H
Sbjct: 372 AAHCGHYR----------------------------VTKLLLDKRANPNARALNGFTPLH 403

Query: 556 YAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRD 615
            A      + +ELL++   +     ES +  +P+H+AA+ GH   +  L +   + DV +
Sbjct: 404 IACKKNRIKVMELLVKYGASIQAITESGL--TPIHVAAFMGHLNIVLLLLQNGASPDVTN 461

Query: 616 HKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSG 675
            +G TAL +A   G  E V  L  +GA    + R+ + TPLH A+  G T+ + LL+   
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ-TPLHIASRLGKTEIVQLLL--- 517

Query: 676 ERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCED 735
           +     D     G TPL ++   G VD   +LLE G+    A  +G T LH  A  G  D
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 577

Query: 736 CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPM 795
               LL   A        G TP+H+A+   +  V   LL+   S          +GY+P+
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH----ATAKNGYTPL 633

Query: 796 HWASYTGHEDCLELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTTEM--LLGALGAKIVN 852
           H A+          LL + +  + +     TPLH A   +Q+  T+M  LL   GA I  
Sbjct: 634 HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA---SQEGHTDMVTLLLDKGANIHM 690

Query: 853 SRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLY 912
           S  + G T LH AA  D V+   +L +H A+ +A    G T L+ A   G    V FLL 
Sbjct: 691 STKS-GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK 749

Query: 913 RGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNG 972
           +G A++    +N  T LH A  +GH     ++L   Q     NAT +     L IA R G
Sbjct: 750 QG-ANVNAKTKNGYTPLHQAAQQGHTHIINVLL---QHGAKPNATTANGNTALAIAKRLG 805

Query: 973 LASVVQAL 980
             SVV  L
Sbjct: 806 YISVVDTL 813



 Score =  283 bits (725), Expect = 5e-76
 Identities = 250/840 (29%), Positives = 362/840 (43%), Gaps = 72/840 (8%)

Query: 80  RAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS 139
           RAA + N   +   L    D+N  ++     LH+AA        + L    SS++ A + 
Sbjct: 37  RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96

Query: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199
           G +ALH A  +G  E V +L+ +GA++N   +    PL+ AA   H++V+K L+  GA+ 
Sbjct: 97  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156

Query: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV 259
                 G+  L  A   G  + V  LL    E D        ALHIA        A  L+
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLL 212

Query: 260 NAGAN--------VNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLH 311
               N        VN+  + GFTPLH+AA   N  +   LL+N GA V++ ++ G +PLH
Sbjct: 213 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPLH 271

Query: 312 MAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIH 371
           +A+  G     ++L+  G +ID   + G TPLH AAR GH+ ++  L+  GA    R  +
Sbjct: 272 VASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331

Query: 372 DMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAA 431
            + PLH+A      +C + LL                   A  D  T D L  T LH AA
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQH----------------KAPVDDVTLDYL--TALHVAA 373

Query: 432 SGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCS 491
             G+     LLL   A+   R   G TPLH A      +    LV  GA +      G +
Sbjct: 374 HCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLT 433

Query: 492 PLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGY 551
           P+H AA                                   +  LL NGA P + + +G 
Sbjct: 434 PIHVAAFMGHLN----------------------------IVLLLLQNGASPDVTNIRGE 465

Query: 552 TAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNL 611
           TA+H AA  G  + +  LL      L D  +    +PLH+A+  G  E ++ L + + + 
Sbjct: 466 TALHMAARAGQVEVVRCLLRN--GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 523

Query: 612 DVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLL 671
           D     G T L ++   G  +   VL   GA+  +   K+ +TPLH AA  G  D   LL
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL-ATKKGFTPLHVAAKYGSLDVAKLL 582

Query: 672 IDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVT 731
           +   +R    D     G TPL +A    +     LLLEKG++  A    G T LH  A  
Sbjct: 583 L---QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 639

Query: 732 GCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSG 791
                 + LL++ A       +G TP+HLAS  GHT ++  LL    +          SG
Sbjct: 640 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK----SG 695

Query: 792 YSPMHWASYTGHEDCLELLLEHSPFSYLEGN-PFTPLHCAVINNQDSTTEMLLGALGAKI 850
            + +H A+     +  ++L +H           +TPL  A           LL   GA  
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL-KQGAN- 753

Query: 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910
           VN++   G TPLH AA   +   + +LLQH A+ NAT   G TAL  A   G  + V+ L
Sbjct: 754 VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score =  268 bits (686), Expect = 2e-71
 Identities = 241/821 (29%), Positives = 373/821 (45%), Gaps = 88/821 (10%)

Query: 213  AAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272
            AA +G ++ V   L+ G +I+  N  G  ALH+A   G   +  EL+  G++V+    KG
Sbjct: 38   AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 273  FTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEI 332
             T LH+A+++    + +++LV  GA++N QS+ G +PL+MAA        + L++NG+  
Sbjct: 98   NTALHIASLAGQAEV-VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156

Query: 333  DCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLL 392
              A + G TPL VA + GH   ++ L+ N  DT  +G   +  LH+A     +     LL
Sbjct: 157  STATEDGFTPLAVALQQGHNQAVAILLEN--DT--KGKVRLPALHIAARKDDTKSAALLL 212

Query: 393  SSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRR 452
             +     + S +       +GF          T LH AA  GNV    LLL+ GA +   
Sbjct: 213  QNDHNADVQSKMMVNRTTESGF----------TPLHIAAHYGNVNVATLLLNRGAAVDFT 262

Query: 453  DKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSS 512
             + G TPLH A+  G+      L+  G  ++     G +PLH AA S             
Sbjct: 263  ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS------------G 310

Query: 513  HDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEM 572
            HD                  +E LL+ GA    R + G + +H AA   + + ++ LL+ 
Sbjct: 311  HDQ----------------VVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354

Query: 573  SFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTE 632
                ++DV     ++ LH+AA+ GH    K L +   N + R   G T L +A ++   +
Sbjct: 355  KAP-VDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK 412

Query: 633  CVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDV--------- 683
             +E+L  +GAS +    +   TP+H AA  GH + + LL+ +G   D+T++         
Sbjct: 413  VMELLVKYGAS-IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471

Query: 684  ------------------MDAYG---QTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGR 722
                              +DA     QTPL +A   G  + V LLL+  +  DAA   G 
Sbjct: 472  ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 531

Query: 723  TALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDP 782
            T LH  A  G  D  + LL+  A       KG TP+H+A+  G   V + LLQ   + D 
Sbjct: 532  TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD- 590

Query: 783  LDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEG-NPFTPLHCAVINNQDSTTEM 841
                   +G +P+H A++  ++    LLLE     +    N +TPLH A   NQ      
Sbjct: 591  ---SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAST 647

Query: 842  LLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAEN 901
            LL   GA+  N    +G TPLH A+   +   + +LL   A ++ +  +G T+L  AA+ 
Sbjct: 648  LLN-YGAE-TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 705

Query: 902  GQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSAL 961
             +    + L   G AD     +   T L +AC  G+ K    +L +  +   +NA     
Sbjct: 706  DKVNVADILTKHG-ADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN---VNAKTKNG 761

Query: 962  QMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002
              PLH AA+ G   ++  LL HGA   A    G+T ALA A
Sbjct: 762  YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNT-ALAIA 801



 Score =  243 bits (621), Expect = 5e-64
 Identities = 220/797 (27%), Positives = 336/797 (42%), Gaps = 118/797 (14%)

Query: 13  VQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDT 72
           ++A  + ++++V   L    +IN  +Q     LH AA  G V ++Q LL  G++V++   
Sbjct: 36  LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95

Query: 73  LWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSS 132
              T LH A+ +   +V+ +L+   A++NA+ +   TPL++AA        + L    ++
Sbjct: 96  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155

Query: 133 LNVADRSGRSALHHAVHSGHLETVNLLL---NKG----ASLNVCDKKER----------- 174
            + A   G + L  A+  GH + V +LL    KG     +L++  +K+            
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 215

Query: 175 -------------------QPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAA 215
                               PLH AA  G++ V  LL+ RGA +    R G   LH A+ 
Sbjct: 216 HNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK 275

Query: 216 SGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTP 275
            G   +VK LL  G +ID     G T LH A   G D V   L+  GA +      G +P
Sbjct: 276 RGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 335

Query: 276 LHVAAVSTN---------------------------GALC-----LELLVNNGADVNYQS 303
           LH+AA   +                            A C      +LL++  A+ N ++
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395

Query: 304 KEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGA 363
             G +PLH+A    R    ++L++ G+ I    + G TP+HVAA  GH  ++  L+ NGA
Sbjct: 396 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455

Query: 364 DTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYS-----------IVSSLSNEHVLSA 412
                 I     LH+A   G  +  R LL +G L             I S L    ++  
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515

Query: 413 GFD-INTPD---NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468
               +  PD     G T LH +A  G V+  ++LL +GA      K G TPLH AA  GS
Sbjct: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575

Query: 469 YQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKE 528
              A  L+   A  + A   G +PLH AA  D  + A                       
Sbjct: 576 LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVA----------------------- 612

Query: 529 AFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSP 588
                  LL+ GA P    + GYT +H AA     Q    LL  ++    ++ +   V+P
Sbjct: 613 -----LLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL--NYGAETNIVTKQGVTP 665

Query: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
           LHLA+  GH + +  L +   N+ +    G T+L LA +       ++LT HGA      
Sbjct: 666 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ-DAH 724

Query: 649 RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL 708
            K  +TPL  A   G+   ++ L+  G      +     G TPL  A   GH   +++LL
Sbjct: 725 TKLGYTPLIVACHYGNVKMVNFLLKQGAN---VNAKTKNGYTPLHQAAQQGHTHIINVLL 781

Query: 709 EKGSTADAADLRGRTAL 725
           + G+  +A    G TAL
Sbjct: 782 QHGAKPNATTANGNTAL 798



 Score =  223 bits (569), Expect = 6e-58
 Identities = 182/599 (30%), Positives = 271/599 (45%), Gaps = 77/599 (12%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           PL  A    +V     LL++   ++   +   TPLH A+  G+  +++LLL  G  ++AK
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
               LTPLH AA S +++V+ LLL   A + AR K   +PLH+AA     +C + L    
Sbjct: 296 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355

Query: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGAS-----------LNVCDKKER----- 174
           + ++       +ALH A H GH     LLL+K A+           L++  KK R     
Sbjct: 356 APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVME 415

Query: 175 -----------------QPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASG 217
                             P+H AAF+GHL ++ LL+  GA     + +G   LH AA +G
Sbjct: 416 LLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG 475

Query: 218 QIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLH 277
           Q+EVV+ LLR GA +D       T LHIA  LG+  +   L+   A+ +     G+TPLH
Sbjct: 476 QVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535

Query: 278 VAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADK 337
           ++A      +   +L+  GA  +  +K+G +PLH+AA +G    +++L+Q  +  D A K
Sbjct: 536 ISAREGQVDVA-SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK 594

Query: 338 FGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQL 397
            G TPLHVAA Y ++ +   L+  GA       +   PLH+A           LL+ G  
Sbjct: 595 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 654

Query: 398 YSIVSS-------LSNEH--------VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLL 442
            +IV+        L+++         +L  G +I+     G T LH AA    V   ++L
Sbjct: 655 TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714

Query: 443 LSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTY 502
              GAD     K G TPL  A   G+ +    L+  GA VN     G +PLH AA     
Sbjct: 715 TKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA----- 769

Query: 503 RRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYG 561
              + HT                       +  LL +GA P+     G TA+  A   G
Sbjct: 770 --QQGHT---------------------HIINVLLQHGAKPNATTANGNTALAIAKRLG 805



 Score =  179 bits (455), Expect = 1e-44
 Identities = 172/625 (27%), Positives = 266/625 (42%), Gaps = 61/625 (9%)

Query: 463  AAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLK 522
            AA  G+    V  +  G  +N  +  G + LH AA        E H              
Sbjct: 38   AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAK-------EGHVG------------ 78

Query: 523  ESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVES 582
                      ++ LL  G+      ++G TA+H A+  G  + +++L++   N   + +S
Sbjct: 79   ---------LVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI--NAQS 127

Query: 583  TIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGA 642
                +PL++AA   H + +K L E   N       G T L +A ++G  + V +L  +  
Sbjct: 128  QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 187

Query: 643  SALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVM-----DAYGQTPLMLAIM 697
                   K +   LH AA    T S  LL+ +   AD+   M        G TPL +A  
Sbjct: 188  KG-----KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242

Query: 698  NGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTP 757
             G+V+   LLL +G+  D     G T LH  +  G  + +  LLD    +  +   G TP
Sbjct: 243  YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 302

Query: 758  IHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPF 816
            +H A+  GH  V+  LL+      PL A    +G SP+H A+   H +C++ LL+H +P 
Sbjct: 303  LHCAARSGHDQVVELLLERGA---PLLARTK-NGLSPLHMAAQGDHVECVKHLLQHKAPV 358

Query: 817  SYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRM 876
              +  +  T LH A        T++LL        N+R   G TPLH A   + +  + +
Sbjct: 359  DDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP--NARALNGFTPLHIACKKNRIKVMEL 416

Query: 877  LLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKG 936
            L+++ A + A   +G T +  AA  G    V  LL  G A   V +    TALH+A   G
Sbjct: 417  LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAG 475

Query: 937  HEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHT 996
              +    +L   ++  L++A     Q PLHIA+R G   +VQ LL H A   A    G+T
Sbjct: 476  QVEVVRCLL---RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT 532

Query: 997  PALACA--PNKDVADCL-----ALILSTMKPFPPKDAVSPFSFSLLKNCSI---AAAKTV 1046
            P    A     DVA  L     A  L+T K F P    + +    +    +   AAA + 
Sbjct: 533  PLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSA 592

Query: 1047 GGCGALPHGASCPYSQERPGAIGLD 1071
            G  G  P   +  Y  ++   + L+
Sbjct: 593  GKNGLTPLHVAAHYDNQKVALLLLE 617



 Score =  166 bits (419), Expect = 1e-40
 Identities = 118/356 (33%), Positives = 178/356 (50%), Gaps = 1/356 (0%)

Query: 3   ILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLM 62
           + +I  +  L  A  +  VE VR LL     ++   +E +TPLH A+ +G   I+QLLL 
Sbjct: 459 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518

Query: 63  SGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKC 122
             A+ +A  T   TPLH +A      V  +LL   A  +   K   TPLHVAA   +   
Sbjct: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578

Query: 123 AEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAF 182
           A+ L    ++ + A ++G + LH A H  + +   LLL KGAS +   K    PLH AA 
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638

Query: 183 LGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTA 242
              +++   L+  GA+     ++G   LH A+  G  ++V  LL  GA I      G T+
Sbjct: 639 KNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS 698

Query: 243 LHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQ 302
           LH+A    +  VA  L   GA+ +     G+TPL VA    N  + +  L+  GA+VN +
Sbjct: 699 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM-VNFLLKQGANVNAK 757

Query: 303 SKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
           +K G +PLH AA  G      +L+Q+G++ +     GNT L +A R G+  ++ TL
Sbjct: 758 TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 61/190 (32%), Positives = 88/190 (46%)

Query: 43  TPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNA 102
           TPLH AA    + I   LL  GA  N      +TPLH A+   +  ++ LLL   A+++ 
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 690

Query: 103 RDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNK 162
             K   T LH+AA       A+ L    +  +   + G + L  A H G+++ VN LL +
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750

Query: 163 GASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVV 222
           GA++N   K    PLH AA  GH  ++ +L+  GA        G   L  A   G I VV
Sbjct: 751 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810

Query: 223 KYLLRMGAEI 232
             L  +  E+
Sbjct: 811 DTLKVVTEEV 820


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  293 bits (751), Expect = 5e-79
 Identities = 256/826 (30%), Positives = 366/826 (44%), Gaps = 82/826 (9%)

Query: 180 AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFG 239
           AA  G+L+     +  G D+   ++ G   LH A+  G +++V  LL     ++     G
Sbjct: 52  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111

Query: 240 NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299
           NTALHIA   GQD V  ELVN GANVN  + KGFTPL++AA   N    ++ L+ NGA+ 
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEVVKFLLENGANQ 170

Query: 300 NYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 359
           N  +++G +PL +A   G       LI  G++     K     LH+AAR       + L+
Sbjct: 171 NVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLL 226

Query: 360 TNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTP 419
            N  +          PLH+A  +   +  + LL+ G               S  F   TP
Sbjct: 227 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG--------------ASVNF---TP 269

Query: 420 DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAG 479
            N G T LH A+  GNV  + LLL  GA +  + K   TPLH AA NG  + +  L+  G
Sbjct: 270 QN-GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 328

Query: 480 AGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDE-------PLKESRRKEAFFC 532
           A +      G SP+H AA  D            +DAE D+       PL  +        
Sbjct: 329 APIQAKTKNGLSPIHMAAQGDHLDCV--RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 386

Query: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592
            + LLD GA P+ R   G+T +H A    + + +ELLL+   +   D  +   ++PLH+A
Sbjct: 387 AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI--DAVTESGLTPLHVA 444

Query: 593 AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRK 652
           ++ GH   +K L +   + +V + K  T L +A   G TE  + L  + A    K  K  
Sbjct: 445 SFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK-AKDD 503

Query: 653 WTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS 712
            TPLH AA  GHT+ + LL+++    ++       G TPL +A   GHV+ V  LLEK +
Sbjct: 504 QTPLHCAARIGHTNMVKLLLENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEA 560

Query: 713 TADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772
           +      +G T LH  A  G       LL+ DA        G TP+H+A    +  +++ 
Sbjct: 561 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKL 620

Query: 773 LLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVI 832
           LL                G SP                  HSP      N +TPLH A  
Sbjct: 621 LLP--------------RGGSP------------------HSP----AWNGYTPLHIAAK 644

Query: 833 NNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGR 892
            NQ      LL   G+   N+   +G TPLH AA   +   + +LL  QA  N  + +G 
Sbjct: 645 QNQVEVARSLLQYGGS--ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 702

Query: 893 TALMTAAENGQTAAVEFLLYRG-KADLTVLDENKNTALHLACSKGHEKCALMILAETQDL 951
           T L   A+ G     + L+  G   D T       T LH+A   G+ K    +L    D 
Sbjct: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATT--RMGYTPLHVASHYGNIKLVKFLLQHQAD- 759

Query: 952 GLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
             +NA       PLH AA+ G   +V  LL +GA+   V  +G TP
Sbjct: 760 --VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 803



 Score =  286 bits (731), Expect = 9e-77
 Identities = 216/705 (30%), Positives = 326/705 (46%), Gaps = 40/705 (5%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           PL  A     +E V+ LL    N NV  ++  TPL  A   G   ++  L+    N   K
Sbjct: 147 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI----NYGTK 202

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
             + L  LH AA + + +   +LL +  + +   K   TPLH+AA       A+ L    
Sbjct: 203 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 262

Query: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190
           +S+N   ++G + LH A   G++  V LLL++GA +    K E  PLH AA  GH+ + +
Sbjct: 263 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 322

Query: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250
           +L+  GA +  K + G   +H AA    ++ V+ LL+  AEID+      T LH+A + G
Sbjct: 323 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 382

Query: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310
              VA  L++ GA  N     GFTPLH+A    N    +ELL+  GA ++  ++ G +PL
Sbjct: 383 HHRVAKVLLDKGAKPNSRALNGFTPLHIAC-KKNHVRVMELLLKTGASIDAVTESGLTPL 441

Query: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGI 370
           H+A+  G     + L+Q G+  + ++    TPLH+AAR GH  +   L+ N A    +  
Sbjct: 442 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 501

Query: 371 HDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAA 430
            D  PLH A   G ++  + LL +                    + N     G T LH A
Sbjct: 502 DDQTPLHCAARIGHTNMVKLLLENNA------------------NPNLATTAGHTPLHIA 543

Query: 431 ASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGC 490
           A  G+VE +  LL   A      K G TPLH AA  G  + A  L+   A  N A   G 
Sbjct: 544 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 603

Query: 491 SPLHYAAASDTY--------RRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGAD 542
           +PLH A   +          R   PH+P+ +      PL  + ++        LL  G  
Sbjct: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY---TPLHIAAKQNQVEVARSLLQYGGS 660

Query: 543 PSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALK 602
            +    QG T +H AA  G+ + + LLL    N   ++ +   ++PLHL A  GH     
Sbjct: 661 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN--GNLGNKSGLTPLHLVAQEGHVPVAD 718

Query: 603 TLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS 662
            L +  V +D     G T L +A+  G+ + V+ L  H A    K  K  ++PLH AA  
Sbjct: 719 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK-TKLGYSPLHQAAQQ 777

Query: 663 GHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLL 707
           GHTD + LL+ +G      + + + G TPL +A   G++    +L
Sbjct: 778 GHTDIVTLLLKNGAS---PNEVSSDGTTPLAIAKRLGYISVTDVL 819



 Score =  278 bits (712), Expect = 2e-74
 Identities = 246/847 (29%), Positives = 369/847 (43%), Gaps = 86/847 (10%)

Query: 76  TPLHRAAASRN-EKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLN 134
           T   RAA S N +K L  L  +  D+N  ++     LH+A+     K    L      L 
Sbjct: 47  TSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 105

Query: 135 VADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVA 194
              + G +ALH A  +G  E V  L+N GA++N   +K   PL+ AA   HLEV+K L+ 
Sbjct: 106 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165

Query: 195 RGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAV 254
            GA+       G+  L  A   G   VV +L+  G +          ALHIA        
Sbjct: 166 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRT 221

Query: 255 AIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAA 314
           A  L+    N +  +  GFTPLH+AA   N  +  +LL+N GA VN+  + G +PLH+A+
Sbjct: 222 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA-QLLLNRGASVNFTPQNGITPLHIAS 280

Query: 315 IHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMF 374
             G     ++L+  G++I+   K   TPLH AAR GH  +   L+ +GA    +  + + 
Sbjct: 281 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 340

Query: 375 PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434
           P+H+A      DC R LL                   A  D  T D+L  T LH AA  G
Sbjct: 341 PIHMAAQGDHLDCVRLLLQ----------------YDAEIDDITLDHL--TPLHVAAHCG 382

Query: 435 NVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLH 494
           +     +LL  GA    R   G TPLH A      +    L+  GA ++     G +PLH
Sbjct: 383 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 442

Query: 495 YAA-------ASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRD 547
            A+         +  +R    +P+  + + + PL  + R       ++LL N A  + + 
Sbjct: 443 VASFMGHLPIVKNLLQRGA--SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500

Query: 548 RQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAET 607
           +   T +H AA  G+   ++LLLE + N   ++ +T   +PLH+AA  GH E +  L E 
Sbjct: 501 KDDQTPLHCAARIGHTNMVKLLLENNAN--PNLATTAGHTPLHIAAREGHVETVLALLEK 558

Query: 608 LVNLDVRDHKGRTALFLATERGSTECVEVL---TAHGASALIKERKRKWTPLHAAAASGH 664
             +      KG T L +A + G     E+L    AH  +A     K   TPLH A    +
Sbjct: 559 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA----GKNGLTPLHVAVHHNN 614

Query: 665 TDSLHLLIDSGERADITDVMDAY-GQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRT 723
            D + LL+  G     +    A+ G TPL +A     V+    LL+ G +A+A  ++G T
Sbjct: 615 LDIVKLLLPRGG----SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 670

Query: 724 ALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPL 783
            LH  A  G  + +A LL   A     +  G TP+HL +  GH  V   L++  +  D  
Sbjct: 671 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD-- 728

Query: 784 DAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLL 843
                  GY+P+H AS+ G+   ++ LL+H                              
Sbjct: 729 --ATTRMGYTPLHVASHYGNIKLVKFLLQHQ----------------------------- 757

Query: 844 GALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQ 903
                  VN++   G +PLH AA   +   + +LL++ A  N     G T L  A   G 
Sbjct: 758 -----ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 812

Query: 904 TAAVEFL 910
            +  + L
Sbjct: 813 ISVTDVL 819



 Score =  256 bits (654), Expect = 8e-68
 Identities = 195/654 (29%), Positives = 302/654 (46%), Gaps = 29/654 (4%)

Query: 10  PPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNA 69
           P L  A  + D      LL    N +VL +   TPLH AA+  ++ + QLLL  GA+VN 
Sbjct: 208 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 267

Query: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
                +TPLH A+   N  ++ LLL   A +  + K   TPLH AA N   + +E L   
Sbjct: 268 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 327

Query: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL 189
            + +    ++G S +H A    HL+ V LLL   A ++        PLH AA  GH  V 
Sbjct: 328 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 387

Query: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYL 249
           K+L+ +GA    +   G+  LH A     + V++ LL+ GA ID     G T LH+A ++
Sbjct: 388 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 447

Query: 250 GQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSP 309
           G   +   L+  GA+ N  N K  TPLH+AA + +  +  + L+ N A VN ++K+ ++P
Sbjct: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTP 506

Query: 310 LHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRG 369
           LH AA  G     ++L++N +  + A   G+TPLH+AAR GH   +  L+   A  A   
Sbjct: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 566

Query: 370 IHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHA 429
                PLH+A  +G       LL             + H  +AG +       G T LH 
Sbjct: 567 KKGFTPLHVAAKYGKVRVAELLLE-----------RDAHPNAAGKN-------GLTPLHV 608

Query: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 489
           A    N++ + LLL  G         G TPLH AA     + A +L+  G   N    +G
Sbjct: 609 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 668

Query: 490 CSPLHYAAASD-----TYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544
            +PLH AA            ++    +  +     PL    ++      + L+ +G    
Sbjct: 669 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 728

Query: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTL 604
              R GYT +H A+ YGN + ++ LL+   +   + ++ +  SPLH AA  GH + +  L
Sbjct: 729 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVTLL 786

Query: 605 AETLVNLDVRDHKGRTALFLATERG---STECVEVLTAHGASALIKERKRKWTP 655
            +   + +     G T L +A   G    T+ ++V+T   +  L+ ++ R   P
Sbjct: 787 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFP 840



 Score =  197 bits (501), Expect = 4e-50
 Identities = 182/627 (29%), Positives = 269/627 (42%), Gaps = 32/627 (5%)

Query: 394  SGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRD 453
            SG L   +  L N      G DINT +  G   LH A+  G+V+ +  LL     L    
Sbjct: 55   SGNLDKALDHLRN------GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 108

Query: 454  KFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE---PHTP 510
            K G T LH AA  G  +    LV  GA VN    KG +PL+ AA  +     +    +  
Sbjct: 109  KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 168

Query: 511  SSHDAEED--EPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLEL 568
            + + A ED   PL  + ++     +  L++ G    +R      A+H AA   + +   +
Sbjct: 169  NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAV 224

Query: 569  LLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATER 628
            LL+   N   DV S    +PLH+AA+  +    + L     +++     G T L +A+ R
Sbjct: 225  LLQNDPN--PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 282

Query: 629  GSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYG 688
            G+   V +L   GA    K  K + TPLH AA +GH     +L+D G            G
Sbjct: 283  GNVIMVRLLLDRGAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQ---AKTKNG 338

Query: 689  QTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVL 748
             +P+ +A    H+DCV LLL+  +  D   L   T LH  A  G       LLD  A   
Sbjct: 339  LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 398

Query: 749  CRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLE 808
             R   G TP+H+A    H  V+  LL+   S D     V  SG +P+H AS+ GH   ++
Sbjct: 399  SRALNGFTPLHIACKKNHVRVMELLLKTGASID----AVTESGLTPLHVASFMGHLPIVK 454

Query: 809  LLLEHSPFSYLEGNPF-TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAF 867
             LL+      +      TPLH A         + LL       VN++    +TPLH AA 
Sbjct: 455  NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK--VNAKAKDDQTPLHCAAR 512

Query: 868  ADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNT 927
              + + +++LL++ A  N     G T L  AA  G    V  LL + +A    + +   T
Sbjct: 513  IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK-EASQACMTKKGFT 571

Query: 928  ALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATV 987
             LH+A   G  + A ++L         NA       PLH+A  +    +V+ LL  G + 
Sbjct: 572  PLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 628

Query: 988  LAVDEEGHTPALACAPNKDVADCLALI 1014
             +    G+TP    A    V    +L+
Sbjct: 629  HSPAWNGYTPLHIAAKQNQVEVARSLL 655



 Score =  112 bits (280), Expect = 2e-24
 Identities = 108/392 (27%), Positives = 166/392 (42%), Gaps = 47/392 (11%)

Query: 647  KERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHL 706
            ++RK+K     +   +  + +L   +D        +  +  G   L LA   GHV  V  
Sbjct: 37   RDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 96

Query: 707  LLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGH 766
            LL K    +    +G TALH  A+ G ++ +  L+++ A V  +  KG TP+++A+   H
Sbjct: 97   LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 156

Query: 767  TAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCL------------------- 807
              V++ LL+   + +         G++P+  A   GHE+ +                   
Sbjct: 157  LEVVKFLLENGANQNV----ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHI 212

Query: 808  ----------ELLLEHSPF-SYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDA 856
                       +LL++ P    L    FTPLH A      +  ++LL   GA  VN    
Sbjct: 213  AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR-GAS-VNFTPQ 270

Query: 857  KGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKA 916
             G TPLH A+   NV  +R+LL   A++        T L  AA NG     E LL  G A
Sbjct: 271  NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG-A 329

Query: 917  DLTVLDENKNTALHLACSKGHEKCALMIL---AETQDLGLINATNSALQMPLHIAARNGL 973
             +    +N  + +H+A    H  C  ++L   AE  D+ L + T      PLH+AA  G 
Sbjct: 330  PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLT------PLHVAAHCGH 383

Query: 974  ASVVQALLSHGATVLAVDEEGHTPA-LACAPN 1004
              V + LL  GA   +    G TP  +AC  N
Sbjct: 384  HRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 415



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 62/188 (32%), Positives = 82/188 (43%), Gaps = 33/188 (17%)

Query: 5   SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSG 64
           S+    PL  A      E V  LLS++ N N+ ++   TPLH  A  G VP+  +L+  G
Sbjct: 665 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 724

Query: 65  ANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAE 124
             V+A   +  TPLH A+   N K++  LL H ADVNA+ KL  +PLH AA         
Sbjct: 725 VMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA--------- 775

Query: 125 ALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLG 184
                                     GH + V LLL  GAS N        PL  A  LG
Sbjct: 776 ------------------------QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLG 811

Query: 185 HLEVLKLL 192
           ++ V  +L
Sbjct: 812 YISVTDVL 819


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  293 bits (751), Expect = 5e-79
 Identities = 256/826 (30%), Positives = 366/826 (44%), Gaps = 82/826 (9%)

Query: 180 AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFG 239
           AA  G+L+     +  G D+   ++ G   LH A+  G +++V  LL     ++     G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 240 NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299
           NTALHIA   GQD V  ELVN GANVN  + KGFTPL++AA   N    ++ L+ NGA+ 
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEVVKFLLENGANQ 137

Query: 300 NYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 359
           N  +++G +PL +A   G       LI  G++     K     LH+AAR       + L+
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLL 193

Query: 360 TNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTP 419
            N  +          PLH+A  +   +  + LL+ G               S  F   TP
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG--------------ASVNF---TP 236

Query: 420 DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAG 479
            N G T LH A+  GNV  + LLL  GA +  + K   TPLH AA NG  + +  L+  G
Sbjct: 237 QN-GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295

Query: 480 AGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDE-------PLKESRRKEAFFC 532
           A +      G SP+H AA  D            +DAE D+       PL  +        
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCV--RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353

Query: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592
            + LLD GA P+ R   G+T +H A    + + +ELLL+   +   D  +   ++PLH+A
Sbjct: 354 AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI--DAVTESGLTPLHVA 411

Query: 593 AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRK 652
           ++ GH   +K L +   + +V + K  T L +A   G TE  + L  + A    K  K  
Sbjct: 412 SFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK-AKDD 470

Query: 653 WTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS 712
            TPLH AA  GHT+ + LL+++    ++       G TPL +A   GHV+ V  LLEK +
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEA 527

Query: 713 TADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772
           +      +G T LH  A  G       LL+ DA        G TP+H+A    +  +++ 
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKL 587

Query: 773 LLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVI 832
           LL                G SP                  HSP      N +TPLH A  
Sbjct: 588 LLP--------------RGGSP------------------HSP----AWNGYTPLHIAAK 611

Query: 833 NNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGR 892
            NQ      LL   G+   N+   +G TPLH AA   +   + +LL  QA  N  + +G 
Sbjct: 612 QNQVEVARSLLQYGGS--ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669

Query: 893 TALMTAAENGQTAAVEFLLYRG-KADLTVLDENKNTALHLACSKGHEKCALMILAETQDL 951
           T L   A+ G     + L+  G   D T       T LH+A   G+ K    +L    D 
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATT--RMGYTPLHVASHYGNIKLVKFLLQHQAD- 726

Query: 952 GLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
             +NA       PLH AA+ G   +V  LL +GA+   V  +G TP
Sbjct: 727 --VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770



 Score =  286 bits (731), Expect = 9e-77
 Identities = 216/705 (30%), Positives = 326/705 (46%), Gaps = 40/705 (5%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           PL  A     +E V+ LL    N NV  ++  TPL  A   G   ++  L+    N   K
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI----NYGTK 169

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
             + L  LH AA + + +   +LL +  + +   K   TPLH+AA       A+ L    
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229

Query: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190
           +S+N   ++G + LH A   G++  V LLL++GA +    K E  PLH AA  GH+ + +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250
           +L+  GA +  K + G   +H AA    ++ V+ LL+  AEID+      T LH+A + G
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349

Query: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310
              VA  L++ GA  N     GFTPLH+A    N    +ELL+  GA ++  ++ G +PL
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIAC-KKNHVRVMELLLKTGASIDAVTESGLTPL 408

Query: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGI 370
           H+A+  G     + L+Q G+  + ++    TPLH+AAR GH  +   L+ N A    +  
Sbjct: 409 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 468

Query: 371 HDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAA 430
            D  PLH A   G ++  + LL +                    + N     G T LH A
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNA------------------NPNLATTAGHTPLHIA 510

Query: 431 ASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGC 490
           A  G+VE +  LL   A      K G TPLH AA  G  + A  L+   A  N A   G 
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570

Query: 491 SPLHYAAASDTY--------RRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGAD 542
           +PLH A   +          R   PH+P+ +      PL  + ++        LL  G  
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY---TPLHIAAKQNQVEVARSLLQYGGS 627

Query: 543 PSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALK 602
            +    QG T +H AA  G+ + + LLL    N   ++ +   ++PLHL A  GH     
Sbjct: 628 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN--GNLGNKSGLTPLHLVAQEGHVPVAD 685

Query: 603 TLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS 662
            L +  V +D     G T L +A+  G+ + V+ L  H A    K  K  ++PLH AA  
Sbjct: 686 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK-TKLGYSPLHQAAQQ 744

Query: 663 GHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLL 707
           GHTD + LL+ +G      + + + G TPL +A   G++    +L
Sbjct: 745 GHTDIVTLLLKNGAS---PNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  283 bits (725), Expect = 5e-76
 Identities = 249/854 (29%), Positives = 379/854 (44%), Gaps = 76/854 (8%)

Query: 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKL 191
           S+   +    ++   A  SG+L+     L  G  +N C++     LH A+  GH++++  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 192 LVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQ 251
           L+ +   L    +KG   LH AA +GQ EVV+ L+  GA ++  +  G T L++A     
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 252 DAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGK---S 308
             V   L+  GAN N   + GFTPL VA    +  +   L       +NY +K GK    
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL-------INYGTK-GKVRLP 175

Query: 309 PLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARR 368
            LH+AA +     + +L+QN    D   K G TPLH+AA Y +  +   L+  GA     
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 369 GIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLH 428
             + + PLH+A   G     R LL  G                A  +  T D L  T LH
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRG----------------AQIETKTKDEL--TPLH 277

Query: 429 AAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCK 488
            AA  G+V    +LL  GA ++ + K G +P+H AA      C   L+   A +++    
Sbjct: 278 CAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD 337

Query: 489 GCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDR 548
             +PLH AA    +R A                            + LLD GA P+ R  
Sbjct: 338 HLTPLHVAAHCGHHRVA----------------------------KVLLDKGAKPNSRAL 369

Query: 549 QGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETL 608
            G+T +H A    + + +ELLL+   +   D  +   ++PLH+A++ GH   +K L +  
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASI--DAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 609 VNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSL 668
            + +V + K  T L +A   G TE  + L  + A    K  K   TPLH AA  GHT+ +
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK-AKDDQTPLHCAARIGHTNMV 486

Query: 669 HLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRG 728
            LL+++    ++       G TPL +A   GHV+ V  LLEK ++      +G T LH  
Sbjct: 487 KLLLENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543

Query: 729 AVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVD 788
           A  G       LL+ DA        G TP+H+A    +  +++ LL    S         
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH----SPA 599

Query: 789 YSGYSPMHWASYTGHEDCLELLLEHSPFSYLEG-NPFTPLHCAVINNQDSTTEMLLGALG 847
           ++GY+P+H A+     +    LL++   +  E     TPLH A    Q+   EM+   L 
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA---QEGHAEMVALLLS 656

Query: 848 AKI-VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAA 906
            +   N  +  G TPLH  A   +V    +L++H   V+AT   G T L  A+  G    
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 907 VEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLH 966
           V+FLL + +AD+    +   + LH A  +GH     ++L   ++    N  +S    PL 
Sbjct: 717 VKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL---KNGASPNEVSSDGTTPLA 772

Query: 967 IAARNGLASVVQAL 980
           IA R G  SV   L
Sbjct: 773 IAKRLGYISVTDVL 786



 Score =  278 bits (712), Expect = 2e-74
 Identities = 246/847 (29%), Positives = 369/847 (43%), Gaps = 86/847 (10%)

Query: 76  TPLHRAAASRN-EKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLN 134
           T   RAA S N +K L  L  +  D+N  ++     LH+A+     K    L      L 
Sbjct: 14  TSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72

Query: 135 VADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVA 194
              + G +ALH A  +G  E V  L+N GA++N   +K   PL+ AA   HLEV+K L+ 
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 195 RGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAV 254
            GA+       G+  L  A   G   VV +L+  G +          ALHIA        
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRT 188

Query: 255 AIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAA 314
           A  L+    N +  +  GFTPLH+AA   N  +  +LL+N GA VN+  + G +PLH+A+
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA-QLLLNRGASVNFTPQNGITPLHIAS 247

Query: 315 IHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMF 374
             G     ++L+  G++I+   K   TPLH AAR GH  +   L+ +GA    +  + + 
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 375 PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434
           P+H+A      DC R LL                   A  D  T D+L  T LH AA  G
Sbjct: 308 PIHMAAQGDHLDCVRLLLQ----------------YDAEIDDITLDHL--TPLHVAAHCG 349

Query: 435 NVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLH 494
           +     +LL  GA    R   G TPLH A      +    L+  GA ++     G +PLH
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 409

Query: 495 YAA-------ASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRD 547
            A+         +  +R    +P+  + + + PL  + R       ++LL N A  + + 
Sbjct: 410 VASFMGHLPIVKNLLQRGA--SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 548 RQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAET 607
           +   T +H AA  G+   ++LLLE + N   ++ +T   +PLH+AA  GH E +  L E 
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNAN--PNLATTAGHTPLHIAAREGHVETVLALLEK 525

Query: 608 LVNLDVRDHKGRTALFLATERGSTECVEVL---TAHGASALIKERKRKWTPLHAAAASGH 664
             +      KG T L +A + G     E+L    AH  +A     K   TPLH A    +
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA----GKNGLTPLHVAVHHNN 581

Query: 665 TDSLHLLIDSGERADITDVMDAY-GQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRT 723
            D + LL+  G     +    A+ G TPL +A     V+    LL+ G +A+A  ++G T
Sbjct: 582 LDIVKLLLPRGG----SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637

Query: 724 ALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPL 783
            LH  A  G  + +A LL   A     +  G TP+HL +  GH  V   L++  +  D  
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD-- 695

Query: 784 DAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLL 843
                  GY+P+H AS+ G+   ++ LL+H                              
Sbjct: 696 --ATTRMGYTPLHVASHYGNIKLVKFLLQHQ----------------------------- 724

Query: 844 GALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQ 903
                  VN++   G +PLH AA   +   + +LL++ A  N     G T L  A   G 
Sbjct: 725 -----ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779

Query: 904 TAAVEFL 910
            +  + L
Sbjct: 780 ISVTDVL 786



 Score =  256 bits (655), Expect = 6e-68
 Identities = 201/684 (29%), Positives = 311/684 (45%), Gaps = 31/684 (4%)

Query: 10  PPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNA 69
           P L  A  + D      LL    N +VL +   TPLH AA+  ++ + QLLL  GA+VN 
Sbjct: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234

Query: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
                +TPLH A+   N  ++ LLL   A +  + K   TPLH AA N   + +E L   
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294

Query: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL 189
            + +    ++G S +H A    HL+ V LLL   A ++        PLH AA  GH  V 
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354

Query: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYL 249
           K+L+ +GA    +   G+  LH A     + V++ LL+ GA ID     G T LH+A ++
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414

Query: 250 GQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSP 309
           G   +   L+  GA+ N  N K  TPLH+AA + +  +  + L+ N A VN ++K+ ++P
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTP 473

Query: 310 LHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRG 369
           LH AA  G     ++L++N +  + A   G+TPLH+AAR GH   +  L+   A  A   
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533

Query: 370 IHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHA 429
                PLH+A  +G       LL             + H  +AG +       G T LH 
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLE-----------RDAHPNAAGKN-------GLTPLHV 575

Query: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 489
           A    N++ + LLL  G         G TPLH AA     + A +L+  G   N    +G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635

Query: 490 CSPLHYAAASD-----TYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544
            +PLH AA            ++    +  +     PL    ++      + L+ +G    
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695

Query: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTL 604
              R GYT +H A+ YGN + ++ LL+   +   + ++ +  SPLH AA  GH + +  L
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVTLL 753

Query: 605 AETLVNLDVRDHKGRTALFLATERG---STECVEVLTAHGASALIKERKRKWTP--LHAA 659
            +   + +     G T L +A   G    T+ ++V+T   +  L+ ++ R   P  +   
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEI 813

Query: 660 AASGHTDSLHLLIDSGERADITDV 683
                 +   L+    ER D  DV
Sbjct: 814 LDVSEDEGEELISFKAERRDSRDV 837



 Score =  197 bits (501), Expect = 4e-50
 Identities = 182/627 (29%), Positives = 269/627 (42%), Gaps = 32/627 (5%)

Query: 394  SGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRD 453
            SG L   +  L N      G DINT +  G   LH A+  G+V+ +  LL     L    
Sbjct: 22   SGNLDKALDHLRN------GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75

Query: 454  KFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE---PHTP 510
            K G T LH AA  G  +    LV  GA VN    KG +PL+ AA  +     +    +  
Sbjct: 76   KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135

Query: 511  SSHDAEED--EPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLEL 568
            + + A ED   PL  + ++     +  L++ G    +R      A+H AA   + +   +
Sbjct: 136  NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAV 191

Query: 569  LLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATER 628
            LL+   N   DV S    +PLH+AA+  +    + L     +++     G T L +A+ R
Sbjct: 192  LLQNDPN--PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249

Query: 629  GSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYG 688
            G+   V +L   GA    K  K + TPLH AA +GH     +L+D G            G
Sbjct: 250  GNVIMVRLLLDRGAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQ---AKTKNG 305

Query: 689  QTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVL 748
             +P+ +A    H+DCV LLL+  +  D   L   T LH  A  G       LLD  A   
Sbjct: 306  LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 749  CRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLE 808
             R   G TP+H+A    H  V+  LL+   S D     V  SG +P+H AS+ GH   ++
Sbjct: 366  SRALNGFTPLHIACKKNHVRVMELLLKTGASID----AVTESGLTPLHVASFMGHLPIVK 421

Query: 809  LLLEHSPFSYLEGNPF-TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAF 867
             LL+      +      TPLH A         + LL       VN++    +TPLH AA 
Sbjct: 422  NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK--VNAKAKDDQTPLHCAAR 479

Query: 868  ADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNT 927
              + + +++LL++ A  N     G T L  AA  G    V  LL + +A    + +   T
Sbjct: 480  IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK-EASQACMTKKGFT 538

Query: 928  ALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATV 987
             LH+A   G  + A ++L         NA       PLH+A  +    +V+ LL  G + 
Sbjct: 539  PLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595

Query: 988  LAVDEEGHTPALACAPNKDVADCLALI 1014
             +    G+TP    A    V    +L+
Sbjct: 596  HSPAWNGYTPLHIAAKQNQVEVARSLL 622



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 6/148 (4%)

Query: 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910
           V  R+A   T    AA + N+      L++  ++N  +  G   L  A++ G    V  L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 911 LYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGL-INATNSALQMPLHIAA 969
           L++ +  L    +  NTALH+A   G ++    ++ E  + G  +NA +     PL++AA
Sbjct: 65  LHK-EIILETTTKKGNTALHIAALAGQDE----VVRELVNYGANVNAQSQKGFTPLYMAA 119

Query: 970 RNGLASVVQALLSHGATVLAVDEEGHTP 997
           +     VV+ LL +GA      E+G TP
Sbjct: 120 QENHLEVVKFLLENGANQNVATEDGFTP 147



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 35/111 (31%), Positives = 55/111 (49%), Gaps = 6/111 (5%)

Query: 893  TALMTAAENGQT-AAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDL 951
            T+ + AA +G    A++ L  R   D+   ++N    LHLA  +GH K  + +L +    
Sbjct: 14   TSFLRAARSGNLDKALDHL--RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI-- 69

Query: 952  GLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002
             ++  T       LHIAA  G   VV+ L+++GA V A  ++G TP    A
Sbjct: 70   -ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  293 bits (751), Expect = 5e-79
 Identities = 256/826 (30%), Positives = 366/826 (44%), Gaps = 82/826 (9%)

Query: 180 AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFG 239
           AA  G+L+     +  G D+   ++ G   LH A+  G +++V  LL     ++     G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 240 NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299
           NTALHIA   GQD V  ELVN GANVN  + KGFTPL++AA   N    ++ L+ NGA+ 
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEVVKFLLENGANQ 137

Query: 300 NYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 359
           N  +++G +PL +A   G       LI  G++     K     LH+AAR       + L+
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLL 193

Query: 360 TNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTP 419
            N  +          PLH+A  +   +  + LL+ G               S  F   TP
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG--------------ASVNF---TP 236

Query: 420 DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAG 479
            N G T LH A+  GNV  + LLL  GA +  + K   TPLH AA NG  + +  L+  G
Sbjct: 237 QN-GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295

Query: 480 AGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDE-------PLKESRRKEAFFC 532
           A +      G SP+H AA  D            +DAE D+       PL  +        
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCV--RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353

Query: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592
            + LLD GA P+ R   G+T +H A    + + +ELLL+   +   D  +   ++PLH+A
Sbjct: 354 AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI--DAVTESGLTPLHVA 411

Query: 593 AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRK 652
           ++ GH   +K L +   + +V + K  T L +A   G TE  + L  + A    K  K  
Sbjct: 412 SFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK-AKDD 470

Query: 653 WTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS 712
            TPLH AA  GHT+ + LL+++    ++       G TPL +A   GHV+ V  LLEK +
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEA 527

Query: 713 TADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772
           +      +G T LH  A  G       LL+ DA        G TP+H+A    +  +++ 
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKL 587

Query: 773 LLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVI 832
           LL                G SP                  HSP      N +TPLH A  
Sbjct: 588 LLP--------------RGGSP------------------HSP----AWNGYTPLHIAAK 611

Query: 833 NNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGR 892
            NQ      LL   G+   N+   +G TPLH AA   +   + +LL  QA  N  + +G 
Sbjct: 612 QNQVEVARSLLQYGGS--ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669

Query: 893 TALMTAAENGQTAAVEFLLYRG-KADLTVLDENKNTALHLACSKGHEKCALMILAETQDL 951
           T L   A+ G     + L+  G   D T       T LH+A   G+ K    +L    D 
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATT--RMGYTPLHVASHYGNIKLVKFLLQHQAD- 726

Query: 952 GLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
             +NA       PLH AA+ G   +V  LL +GA+   V  +G TP
Sbjct: 727 --VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770



 Score =  286 bits (731), Expect = 9e-77
 Identities = 216/705 (30%), Positives = 326/705 (46%), Gaps = 40/705 (5%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           PL  A     +E V+ LL    N NV  ++  TPL  A   G   ++  L+    N   K
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI----NYGTK 169

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
             + L  LH AA + + +   +LL +  + +   K   TPLH+AA       A+ L    
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229

Query: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190
           +S+N   ++G + LH A   G++  V LLL++GA +    K E  PLH AA  GH+ + +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250
           +L+  GA +  K + G   +H AA    ++ V+ LL+  AEID+      T LH+A + G
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349

Query: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310
              VA  L++ GA  N     GFTPLH+A    N    +ELL+  GA ++  ++ G +PL
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIAC-KKNHVRVMELLLKTGASIDAVTESGLTPL 408

Query: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGI 370
           H+A+  G     + L+Q G+  + ++    TPLH+AAR GH  +   L+ N A    +  
Sbjct: 409 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 468

Query: 371 HDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAA 430
            D  PLH A   G ++  + LL +                    + N     G T LH A
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNA------------------NPNLATTAGHTPLHIA 510

Query: 431 ASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGC 490
           A  G+VE +  LL   A      K G TPLH AA  G  + A  L+   A  N A   G 
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570

Query: 491 SPLHYAAASDTY--------RRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGAD 542
           +PLH A   +          R   PH+P+ +      PL  + ++        LL  G  
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY---TPLHIAAKQNQVEVARSLLQYGGS 627

Query: 543 PSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALK 602
            +    QG T +H AA  G+ + + LLL    N   ++ +   ++PLHL A  GH     
Sbjct: 628 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN--GNLGNKSGLTPLHLVAQEGHVPVAD 685

Query: 603 TLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS 662
            L +  V +D     G T L +A+  G+ + V+ L  H A    K  K  ++PLH AA  
Sbjct: 686 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK-TKLGYSPLHQAAQQ 744

Query: 663 GHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLL 707
           GHTD + LL+ +G      + + + G TPL +A   G++    +L
Sbjct: 745 GHTDIVTLLLKNGAS---PNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  283 bits (725), Expect = 5e-76
 Identities = 249/854 (29%), Positives = 379/854 (44%), Gaps = 76/854 (8%)

Query: 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKL 191
           S+   +    ++   A  SG+L+     L  G  +N C++     LH A+  GH++++  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 192 LVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQ 251
           L+ +   L    +KG   LH AA +GQ EVV+ L+  GA ++  +  G T L++A     
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 252 DAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGK---S 308
             V   L+  GAN N   + GFTPL VA    +  +   L       +NY +K GK    
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL-------INYGTK-GKVRLP 175

Query: 309 PLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARR 368
            LH+AA +     + +L+QN    D   K G TPLH+AA Y +  +   L+  GA     
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 369 GIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLH 428
             + + PLH+A   G     R LL  G                A  +  T D L  T LH
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRG----------------AQIETKTKDEL--TPLH 277

Query: 429 AAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCK 488
            AA  G+V    +LL  GA ++ + K G +P+H AA      C   L+   A +++    
Sbjct: 278 CAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD 337

Query: 489 GCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDR 548
             +PLH AA    +R A                            + LLD GA P+ R  
Sbjct: 338 HLTPLHVAAHCGHHRVA----------------------------KVLLDKGAKPNSRAL 369

Query: 549 QGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETL 608
            G+T +H A    + + +ELLL+   +   D  +   ++PLH+A++ GH   +K L +  
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASI--DAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 609 VNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSL 668
            + +V + K  T L +A   G TE  + L  + A    K  K   TPLH AA  GHT+ +
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK-AKDDQTPLHCAARIGHTNMV 486

Query: 669 HLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRG 728
            LL+++    ++       G TPL +A   GHV+ V  LLEK ++      +G T LH  
Sbjct: 487 KLLLENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543

Query: 729 AVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVD 788
           A  G       LL+ DA        G TP+H+A    +  +++ LL    S         
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH----SPA 599

Query: 789 YSGYSPMHWASYTGHEDCLELLLEHSPFSYLEG-NPFTPLHCAVINNQDSTTEMLLGALG 847
           ++GY+P+H A+     +    LL++   +  E     TPLH A    Q+   EM+   L 
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA---QEGHAEMVALLLS 656

Query: 848 AKI-VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAA 906
            +   N  +  G TPLH  A   +V    +L++H   V+AT   G T L  A+  G    
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 907 VEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLH 966
           V+FLL + +AD+    +   + LH A  +GH     ++L   ++    N  +S    PL 
Sbjct: 717 VKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL---KNGASPNEVSSDGTTPLA 772

Query: 967 IAARNGLASVVQAL 980
           IA R G  SV   L
Sbjct: 773 IAKRLGYISVTDVL 786



 Score =  278 bits (712), Expect = 2e-74
 Identities = 246/847 (29%), Positives = 369/847 (43%), Gaps = 86/847 (10%)

Query: 76  TPLHRAAASRN-EKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLN 134
           T   RAA S N +K L  L  +  D+N  ++     LH+A+     K    L      L 
Sbjct: 14  TSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72

Query: 135 VADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVA 194
              + G +ALH A  +G  E V  L+N GA++N   +K   PL+ AA   HLEV+K L+ 
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 195 RGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAV 254
            GA+       G+  L  A   G   VV +L+  G +          ALHIA        
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRT 188

Query: 255 AIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAA 314
           A  L+    N +  +  GFTPLH+AA   N  +  +LL+N GA VN+  + G +PLH+A+
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA-QLLLNRGASVNFTPQNGITPLHIAS 247

Query: 315 IHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMF 374
             G     ++L+  G++I+   K   TPLH AAR GH  +   L+ +GA    +  + + 
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 375 PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434
           P+H+A      DC R LL                   A  D  T D+L  T LH AA  G
Sbjct: 308 PIHMAAQGDHLDCVRLLLQ----------------YDAEIDDITLDHL--TPLHVAAHCG 349

Query: 435 NVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLH 494
           +     +LL  GA    R   G TPLH A      +    L+  GA ++     G +PLH
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 409

Query: 495 YAA-------ASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRD 547
            A+         +  +R    +P+  + + + PL  + R       ++LL N A  + + 
Sbjct: 410 VASFMGHLPIVKNLLQRGA--SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 548 RQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAET 607
           +   T +H AA  G+   ++LLLE + N   ++ +T   +PLH+AA  GH E +  L E 
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNAN--PNLATTAGHTPLHIAAREGHVETVLALLEK 525

Query: 608 LVNLDVRDHKGRTALFLATERGSTECVEVL---TAHGASALIKERKRKWTPLHAAAASGH 664
             +      KG T L +A + G     E+L    AH  +A     K   TPLH A    +
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA----GKNGLTPLHVAVHHNN 581

Query: 665 TDSLHLLIDSGERADITDVMDAY-GQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRT 723
            D + LL+  G     +    A+ G TPL +A     V+    LL+ G +A+A  ++G T
Sbjct: 582 LDIVKLLLPRGG----SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637

Query: 724 ALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPL 783
            LH  A  G  + +A LL   A     +  G TP+HL +  GH  V   L++  +  D  
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD-- 695

Query: 784 DAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLL 843
                  GY+P+H AS+ G+   ++ LL+H                              
Sbjct: 696 --ATTRMGYTPLHVASHYGNIKLVKFLLQHQ----------------------------- 724

Query: 844 GALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQ 903
                  VN++   G +PLH AA   +   + +LL++ A  N     G T L  A   G 
Sbjct: 725 -----ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779

Query: 904 TAAVEFL 910
            +  + L
Sbjct: 780 ISVTDVL 786



 Score =  256 bits (655), Expect = 6e-68
 Identities = 201/684 (29%), Positives = 311/684 (45%), Gaps = 31/684 (4%)

Query: 10  PPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNA 69
           P L  A  + D      LL    N +VL +   TPLH AA+  ++ + QLLL  GA+VN 
Sbjct: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234

Query: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
                +TPLH A+   N  ++ LLL   A +  + K   TPLH AA N   + +E L   
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294

Query: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL 189
            + +    ++G S +H A    HL+ V LLL   A ++        PLH AA  GH  V 
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354

Query: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYL 249
           K+L+ +GA    +   G+  LH A     + V++ LL+ GA ID     G T LH+A ++
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414

Query: 250 GQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSP 309
           G   +   L+  GA+ N  N K  TPLH+AA + +  +  + L+ N A VN ++K+ ++P
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTP 473

Query: 310 LHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRG 369
           LH AA  G     ++L++N +  + A   G+TPLH+AAR GH   +  L+   A  A   
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533

Query: 370 IHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHA 429
                PLH+A  +G       LL             + H  +AG +       G T LH 
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLE-----------RDAHPNAAGKN-------GLTPLHV 575

Query: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 489
           A    N++ + LLL  G         G TPLH AA     + A +L+  G   N    +G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635

Query: 490 CSPLHYAAASD-----TYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544
            +PLH AA            ++    +  +     PL    ++      + L+ +G    
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695

Query: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTL 604
              R GYT +H A+ YGN + ++ LL+   +   + ++ +  SPLH AA  GH + +  L
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVTLL 753

Query: 605 AETLVNLDVRDHKGRTALFLATERG---STECVEVLTAHGASALIKERKRKWTP--LHAA 659
            +   + +     G T L +A   G    T+ ++V+T   +  L+ ++ R   P  +   
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEI 813

Query: 660 AASGHTDSLHLLIDSGERADITDV 683
                 +   L+    ER D  DV
Sbjct: 814 LDVSEDEGEELISFKAERRDSRDV 837



 Score =  197 bits (501), Expect = 4e-50
 Identities = 182/627 (29%), Positives = 269/627 (42%), Gaps = 32/627 (5%)

Query: 394  SGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRD 453
            SG L   +  L N      G DINT +  G   LH A+  G+V+ +  LL     L    
Sbjct: 22   SGNLDKALDHLRN------GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75

Query: 454  KFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE---PHTP 510
            K G T LH AA  G  +    LV  GA VN    KG +PL+ AA  +     +    +  
Sbjct: 76   KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135

Query: 511  SSHDAEED--EPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLEL 568
            + + A ED   PL  + ++     +  L++ G    +R      A+H AA   + +   +
Sbjct: 136  NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAV 191

Query: 569  LLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATER 628
            LL+   N   DV S    +PLH+AA+  +    + L     +++     G T L +A+ R
Sbjct: 192  LLQNDPN--PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249

Query: 629  GSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYG 688
            G+   V +L   GA    K  K + TPLH AA +GH     +L+D G            G
Sbjct: 250  GNVIMVRLLLDRGAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQ---AKTKNG 305

Query: 689  QTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVL 748
             +P+ +A    H+DCV LLL+  +  D   L   T LH  A  G       LLD  A   
Sbjct: 306  LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 749  CRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLE 808
             R   G TP+H+A    H  V+  LL+   S D     V  SG +P+H AS+ GH   ++
Sbjct: 366  SRALNGFTPLHIACKKNHVRVMELLLKTGASID----AVTESGLTPLHVASFMGHLPIVK 421

Query: 809  LLLEHSPFSYLEGNPF-TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAF 867
             LL+      +      TPLH A         + LL       VN++    +TPLH AA 
Sbjct: 422  NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK--VNAKAKDDQTPLHCAAR 479

Query: 868  ADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNT 927
              + + +++LL++ A  N     G T L  AA  G    V  LL + +A    + +   T
Sbjct: 480  IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK-EASQACMTKKGFT 538

Query: 928  ALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATV 987
             LH+A   G  + A ++L         NA       PLH+A  +    +V+ LL  G + 
Sbjct: 539  PLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595

Query: 988  LAVDEEGHTPALACAPNKDVADCLALI 1014
             +    G+TP    A    V    +L+
Sbjct: 596  HSPAWNGYTPLHIAAKQNQVEVARSLL 622



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 6/148 (4%)

Query: 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910
           V  R+A   T    AA + N+      L++  ++N  +  G   L  A++ G    V  L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 911 LYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGL-INATNSALQMPLHIAA 969
           L++ +  L    +  NTALH+A   G ++    ++ E  + G  +NA +     PL++AA
Sbjct: 65  LHK-EIILETTTKKGNTALHIAALAGQDE----VVRELVNYGANVNAQSQKGFTPLYMAA 119

Query: 970 RNGLASVVQALLSHGATVLAVDEEGHTP 997
           +     VV+ LL +GA      E+G TP
Sbjct: 120 QENHLEVVKFLLENGANQNVATEDGFTP 147



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 35/111 (31%), Positives = 55/111 (49%), Gaps = 6/111 (5%)

Query: 893  TALMTAAENGQT-AAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDL 951
            T+ + AA +G    A++ L  R   D+   ++N    LHLA  +GH K  + +L +    
Sbjct: 14   TSFLRAARSGNLDKALDHL--RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI-- 69

Query: 952  GLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002
             ++  T       LHIAA  G   VV+ L+++GA V A  ++G TP    A
Sbjct: 70   -ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  293 bits (751), Expect = 5e-79
 Identities = 256/826 (30%), Positives = 366/826 (44%), Gaps = 82/826 (9%)

Query: 180 AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFG 239
           AA  G+L+     +  G D+   ++ G   LH A+  G +++V  LL     ++     G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 240 NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299
           NTALHIA   GQD V  ELVN GANVN  + KGFTPL++AA   N    ++ L+ NGA+ 
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEVVKFLLENGANQ 137

Query: 300 NYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 359
           N  +++G +PL +A   G       LI  G++     K     LH+AAR       + L+
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLL 193

Query: 360 TNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTP 419
            N  +          PLH+A  +   +  + LL+ G               S  F   TP
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG--------------ASVNF---TP 236

Query: 420 DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAG 479
            N G T LH A+  GNV  + LLL  GA +  + K   TPLH AA NG  + +  L+  G
Sbjct: 237 QN-GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295

Query: 480 AGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDE-------PLKESRRKEAFFC 532
           A +      G SP+H AA  D            +DAE D+       PL  +        
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCV--RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353

Query: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592
            + LLD GA P+ R   G+T +H A    + + +ELLL+   +   D  +   ++PLH+A
Sbjct: 354 AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI--DAVTESGLTPLHVA 411

Query: 593 AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRK 652
           ++ GH   +K L +   + +V + K  T L +A   G TE  + L  + A    K  K  
Sbjct: 412 SFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK-AKDD 470

Query: 653 WTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS 712
            TPLH AA  GHT+ + LL+++    ++       G TPL +A   GHV+ V  LLEK +
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEA 527

Query: 713 TADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772
           +      +G T LH  A  G       LL+ DA        G TP+H+A    +  +++ 
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKL 587

Query: 773 LLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVI 832
           LL                G SP                  HSP      N +TPLH A  
Sbjct: 588 LLP--------------RGGSP------------------HSP----AWNGYTPLHIAAK 611

Query: 833 NNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGR 892
            NQ      LL   G+   N+   +G TPLH AA   +   + +LL  QA  N  + +G 
Sbjct: 612 QNQVEVARSLLQYGGS--ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669

Query: 893 TALMTAAENGQTAAVEFLLYRG-KADLTVLDENKNTALHLACSKGHEKCALMILAETQDL 951
           T L   A+ G     + L+  G   D T       T LH+A   G+ K    +L    D 
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATT--RMGYTPLHVASHYGNIKLVKFLLQHQAD- 726

Query: 952 GLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
             +NA       PLH AA+ G   +V  LL +GA+   V  +G TP
Sbjct: 727 --VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770



 Score =  286 bits (731), Expect = 9e-77
 Identities = 216/705 (30%), Positives = 326/705 (46%), Gaps = 40/705 (5%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           PL  A     +E V+ LL    N NV  ++  TPL  A   G   ++  L+    N   K
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI----NYGTK 169

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
             + L  LH AA + + +   +LL +  + +   K   TPLH+AA       A+ L    
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229

Query: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190
           +S+N   ++G + LH A   G++  V LLL++GA +    K E  PLH AA  GH+ + +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250
           +L+  GA +  K + G   +H AA    ++ V+ LL+  AEID+      T LH+A + G
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349

Query: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310
              VA  L++ GA  N     GFTPLH+A    N    +ELL+  GA ++  ++ G +PL
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIAC-KKNHVRVMELLLKTGASIDAVTESGLTPL 408

Query: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGI 370
           H+A+  G     + L+Q G+  + ++    TPLH+AAR GH  +   L+ N A    +  
Sbjct: 409 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 468

Query: 371 HDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAA 430
            D  PLH A   G ++  + LL +                    + N     G T LH A
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNA------------------NPNLATTAGHTPLHIA 510

Query: 431 ASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGC 490
           A  G+VE +  LL   A      K G TPLH AA  G  + A  L+   A  N A   G 
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570

Query: 491 SPLHYAAASDTY--------RRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGAD 542
           +PLH A   +          R   PH+P+ +      PL  + ++        LL  G  
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY---TPLHIAAKQNQVEVARSLLQYGGS 627

Query: 543 PSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALK 602
            +    QG T +H AA  G+ + + LLL    N   ++ +   ++PLHL A  GH     
Sbjct: 628 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN--GNLGNKSGLTPLHLVAQEGHVPVAD 685

Query: 603 TLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS 662
            L +  V +D     G T L +A+  G+ + V+ L  H A    K  K  ++PLH AA  
Sbjct: 686 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK-TKLGYSPLHQAAQQ 744

Query: 663 GHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLL 707
           GHTD + LL+ +G      + + + G TPL +A   G++    +L
Sbjct: 745 GHTDIVTLLLKNGAS---PNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  283 bits (725), Expect = 5e-76
 Identities = 249/854 (29%), Positives = 379/854 (44%), Gaps = 76/854 (8%)

Query: 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKL 191
           S+   +    ++   A  SG+L+     L  G  +N C++     LH A+  GH++++  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 192 LVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQ 251
           L+ +   L    +KG   LH AA +GQ EVV+ L+  GA ++  +  G T L++A     
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 252 DAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGK---S 308
             V   L+  GAN N   + GFTPL VA    +  +   L       +NY +K GK    
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL-------INYGTK-GKVRLP 175

Query: 309 PLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARR 368
            LH+AA +     + +L+QN    D   K G TPLH+AA Y +  +   L+  GA     
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 369 GIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLH 428
             + + PLH+A   G     R LL  G                A  +  T D L  T LH
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRG----------------AQIETKTKDEL--TPLH 277

Query: 429 AAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCK 488
            AA  G+V    +LL  GA ++ + K G +P+H AA      C   L+   A +++    
Sbjct: 278 CAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD 337

Query: 489 GCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDR 548
             +PLH AA    +R A                            + LLD GA P+ R  
Sbjct: 338 HLTPLHVAAHCGHHRVA----------------------------KVLLDKGAKPNSRAL 369

Query: 549 QGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETL 608
            G+T +H A    + + +ELLL+   +   D  +   ++PLH+A++ GH   +K L +  
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASI--DAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 609 VNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSL 668
            + +V + K  T L +A   G TE  + L  + A    K  K   TPLH AA  GHT+ +
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK-AKDDQTPLHCAARIGHTNMV 486

Query: 669 HLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRG 728
            LL+++    ++       G TPL +A   GHV+ V  LLEK ++      +G T LH  
Sbjct: 487 KLLLENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543

Query: 729 AVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVD 788
           A  G       LL+ DA        G TP+H+A    +  +++ LL    S         
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH----SPA 599

Query: 789 YSGYSPMHWASYTGHEDCLELLLEHSPFSYLEG-NPFTPLHCAVINNQDSTTEMLLGALG 847
           ++GY+P+H A+     +    LL++   +  E     TPLH A    Q+   EM+   L 
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA---QEGHAEMVALLLS 656

Query: 848 AKI-VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAA 906
            +   N  +  G TPLH  A   +V    +L++H   V+AT   G T L  A+  G    
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 907 VEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLH 966
           V+FLL + +AD+    +   + LH A  +GH     ++L   ++    N  +S    PL 
Sbjct: 717 VKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL---KNGASPNEVSSDGTTPLA 772

Query: 967 IAARNGLASVVQAL 980
           IA R G  SV   L
Sbjct: 773 IAKRLGYISVTDVL 786



 Score =  278 bits (712), Expect = 2e-74
 Identities = 246/847 (29%), Positives = 369/847 (43%), Gaps = 86/847 (10%)

Query: 76  TPLHRAAASRN-EKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLN 134
           T   RAA S N +K L  L  +  D+N  ++     LH+A+     K    L      L 
Sbjct: 14  TSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72

Query: 135 VADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVA 194
              + G +ALH A  +G  E V  L+N GA++N   +K   PL+ AA   HLEV+K L+ 
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 195 RGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAV 254
            GA+       G+  L  A   G   VV +L+  G +          ALHIA        
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRT 188

Query: 255 AIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAA 314
           A  L+    N +  +  GFTPLH+AA   N  +  +LL+N GA VN+  + G +PLH+A+
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA-QLLLNRGASVNFTPQNGITPLHIAS 247

Query: 315 IHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMF 374
             G     ++L+  G++I+   K   TPLH AAR GH  +   L+ +GA    +  + + 
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 375 PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434
           P+H+A      DC R LL                   A  D  T D+L  T LH AA  G
Sbjct: 308 PIHMAAQGDHLDCVRLLLQ----------------YDAEIDDITLDHL--TPLHVAAHCG 349

Query: 435 NVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLH 494
           +     +LL  GA    R   G TPLH A      +    L+  GA ++     G +PLH
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 409

Query: 495 YAA-------ASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRD 547
            A+         +  +R    +P+  + + + PL  + R       ++LL N A  + + 
Sbjct: 410 VASFMGHLPIVKNLLQRGA--SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 548 RQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAET 607
           +   T +H AA  G+   ++LLLE + N   ++ +T   +PLH+AA  GH E +  L E 
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNAN--PNLATTAGHTPLHIAAREGHVETVLALLEK 525

Query: 608 LVNLDVRDHKGRTALFLATERGSTECVEVL---TAHGASALIKERKRKWTPLHAAAASGH 664
             +      KG T L +A + G     E+L    AH  +A     K   TPLH A    +
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA----GKNGLTPLHVAVHHNN 581

Query: 665 TDSLHLLIDSGERADITDVMDAY-GQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRT 723
            D + LL+  G     +    A+ G TPL +A     V+    LL+ G +A+A  ++G T
Sbjct: 582 LDIVKLLLPRGG----SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637

Query: 724 ALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPL 783
            LH  A  G  + +A LL   A     +  G TP+HL +  GH  V   L++  +  D  
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD-- 695

Query: 784 DAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLL 843
                  GY+P+H AS+ G+   ++ LL+H                              
Sbjct: 696 --ATTRMGYTPLHVASHYGNIKLVKFLLQHQ----------------------------- 724

Query: 844 GALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQ 903
                  VN++   G +PLH AA   +   + +LL++ A  N     G T L  A   G 
Sbjct: 725 -----ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779

Query: 904 TAAVEFL 910
            +  + L
Sbjct: 780 ISVTDVL 786



 Score =  256 bits (655), Expect = 6e-68
 Identities = 201/684 (29%), Positives = 311/684 (45%), Gaps = 31/684 (4%)

Query: 10  PPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNA 69
           P L  A  + D      LL    N +VL +   TPLH AA+  ++ + QLLL  GA+VN 
Sbjct: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234

Query: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
                +TPLH A+   N  ++ LLL   A +  + K   TPLH AA N   + +E L   
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294

Query: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL 189
            + +    ++G S +H A    HL+ V LLL   A ++        PLH AA  GH  V 
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354

Query: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYL 249
           K+L+ +GA    +   G+  LH A     + V++ LL+ GA ID     G T LH+A ++
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414

Query: 250 GQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSP 309
           G   +   L+  GA+ N  N K  TPLH+AA + +  +  + L+ N A VN ++K+ ++P
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTP 473

Query: 310 LHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRG 369
           LH AA  G     ++L++N +  + A   G+TPLH+AAR GH   +  L+   A  A   
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533

Query: 370 IHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHA 429
                PLH+A  +G       LL             + H  +AG +       G T LH 
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLE-----------RDAHPNAAGKN-------GLTPLHV 575

Query: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 489
           A    N++ + LLL  G         G TPLH AA     + A +L+  G   N    +G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635

Query: 490 CSPLHYAAASD-----TYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544
            +PLH AA            ++    +  +     PL    ++      + L+ +G    
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695

Query: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTL 604
              R GYT +H A+ YGN + ++ LL+   +   + ++ +  SPLH AA  GH + +  L
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVTLL 753

Query: 605 AETLVNLDVRDHKGRTALFLATERG---STECVEVLTAHGASALIKERKRKWTP--LHAA 659
            +   + +     G T L +A   G    T+ ++V+T   +  L+ ++ R   P  +   
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEI 813

Query: 660 AASGHTDSLHLLIDSGERADITDV 683
                 +   L+    ER D  DV
Sbjct: 814 LDVSEDEGEELISFKAERRDSRDV 837



 Score =  197 bits (501), Expect = 4e-50
 Identities = 182/627 (29%), Positives = 269/627 (42%), Gaps = 32/627 (5%)

Query: 394  SGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRD 453
            SG L   +  L N      G DINT +  G   LH A+  G+V+ +  LL     L    
Sbjct: 22   SGNLDKALDHLRN------GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75

Query: 454  KFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE---PHTP 510
            K G T LH AA  G  +    LV  GA VN    KG +PL+ AA  +     +    +  
Sbjct: 76   KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135

Query: 511  SSHDAEED--EPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLEL 568
            + + A ED   PL  + ++     +  L++ G    +R      A+H AA   + +   +
Sbjct: 136  NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAV 191

Query: 569  LLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATER 628
            LL+   N   DV S    +PLH+AA+  +    + L     +++     G T L +A+ R
Sbjct: 192  LLQNDPN--PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249

Query: 629  GSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYG 688
            G+   V +L   GA    K  K + TPLH AA +GH     +L+D G            G
Sbjct: 250  GNVIMVRLLLDRGAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQ---AKTKNG 305

Query: 689  QTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVL 748
             +P+ +A    H+DCV LLL+  +  D   L   T LH  A  G       LLD  A   
Sbjct: 306  LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 749  CRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLE 808
             R   G TP+H+A    H  V+  LL+   S D     V  SG +P+H AS+ GH   ++
Sbjct: 366  SRALNGFTPLHIACKKNHVRVMELLLKTGASID----AVTESGLTPLHVASFMGHLPIVK 421

Query: 809  LLLEHSPFSYLEGNPF-TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAF 867
             LL+      +      TPLH A         + LL       VN++    +TPLH AA 
Sbjct: 422  NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK--VNAKAKDDQTPLHCAAR 479

Query: 868  ADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNT 927
              + + +++LL++ A  N     G T L  AA  G    V  LL + +A    + +   T
Sbjct: 480  IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK-EASQACMTKKGFT 538

Query: 928  ALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATV 987
             LH+A   G  + A ++L         NA       PLH+A  +    +V+ LL  G + 
Sbjct: 539  PLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595

Query: 988  LAVDEEGHTPALACAPNKDVADCLALI 1014
             +    G+TP    A    V    +L+
Sbjct: 596  HSPAWNGYTPLHIAAKQNQVEVARSLL 622



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 6/148 (4%)

Query: 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910
           V  R+A   T    AA + N+      L++  ++N  +  G   L  A++ G    V  L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 911 LYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGL-INATNSALQMPLHIAA 969
           L++ +  L    +  NTALH+A   G ++    ++ E  + G  +NA +     PL++AA
Sbjct: 65  LHK-EIILETTTKKGNTALHIAALAGQDE----VVRELVNYGANVNAQSQKGFTPLYMAA 119

Query: 970 RNGLASVVQALLSHGATVLAVDEEGHTP 997
           +     VV+ LL +GA      E+G TP
Sbjct: 120 QENHLEVVKFLLENGANQNVATEDGFTP 147



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 35/111 (31%), Positives = 55/111 (49%), Gaps = 6/111 (5%)

Query: 893  TALMTAAENGQT-AAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDL 951
            T+ + AA +G    A++ L  R   D+   ++N    LHLA  +GH K  + +L +    
Sbjct: 14   TSFLRAARSGNLDKALDHL--RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI-- 69

Query: 952  GLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002
             ++  T       LHIAA  G   VV+ L+++GA V A  ++G TP    A
Sbjct: 70   -ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  293 bits (751), Expect = 5e-79
 Identities = 256/826 (30%), Positives = 366/826 (44%), Gaps = 82/826 (9%)

Query: 180 AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFG 239
           AA  G+L+     +  G D+   ++ G   LH A+  G +++V  LL     ++     G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 240 NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299
           NTALHIA   GQD V  ELVN GANVN  + KGFTPL++AA   N    ++ L+ NGA+ 
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEVVKFLLENGANQ 137

Query: 300 NYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 359
           N  +++G +PL +A   G       LI  G++     K     LH+AAR       + L+
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLL 193

Query: 360 TNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTP 419
            N  +          PLH+A  +   +  + LL+ G               S  F   TP
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG--------------ASVNF---TP 236

Query: 420 DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAG 479
            N G T LH A+  GNV  + LLL  GA +  + K   TPLH AA NG  + +  L+  G
Sbjct: 237 QN-GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295

Query: 480 AGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDE-------PLKESRRKEAFFC 532
           A +      G SP+H AA  D            +DAE D+       PL  +        
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCV--RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353

Query: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592
            + LLD GA P+ R   G+T +H A    + + +ELLL+   +   D  +   ++PLH+A
Sbjct: 354 AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI--DAVTESGLTPLHVA 411

Query: 593 AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRK 652
           ++ GH   +K L +   + +V + K  T L +A   G TE  + L  + A    K  K  
Sbjct: 412 SFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK-AKDD 470

Query: 653 WTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS 712
            TPLH AA  GHT+ + LL+++    ++       G TPL +A   GHV+ V  LLEK +
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEA 527

Query: 713 TADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772
           +      +G T LH  A  G       LL+ DA        G TP+H+A    +  +++ 
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKL 587

Query: 773 LLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVI 832
           LL                G SP                  HSP      N +TPLH A  
Sbjct: 588 LLP--------------RGGSP------------------HSP----AWNGYTPLHIAAK 611

Query: 833 NNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGR 892
            NQ      LL   G+   N+   +G TPLH AA   +   + +LL  QA  N  + +G 
Sbjct: 612 QNQVEVARSLLQYGGS--ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669

Query: 893 TALMTAAENGQTAAVEFLLYRG-KADLTVLDENKNTALHLACSKGHEKCALMILAETQDL 951
           T L   A+ G     + L+  G   D T       T LH+A   G+ K    +L    D 
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATT--RMGYTPLHVASHYGNIKLVKFLLQHQAD- 726

Query: 952 GLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
             +NA       PLH AA+ G   +V  LL +GA+   V  +G TP
Sbjct: 727 --VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770



 Score =  286 bits (731), Expect = 9e-77
 Identities = 216/705 (30%), Positives = 326/705 (46%), Gaps = 40/705 (5%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           PL  A     +E V+ LL    N NV  ++  TPL  A   G   ++  L+    N   K
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI----NYGTK 169

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
             + L  LH AA + + +   +LL +  + +   K   TPLH+AA       A+ L    
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229

Query: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190
           +S+N   ++G + LH A   G++  V LLL++GA +    K E  PLH AA  GH+ + +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250
           +L+  GA +  K + G   +H AA    ++ V+ LL+  AEID+      T LH+A + G
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349

Query: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310
              VA  L++ GA  N     GFTPLH+A    N    +ELL+  GA ++  ++ G +PL
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIAC-KKNHVRVMELLLKTGASIDAVTESGLTPL 408

Query: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGI 370
           H+A+  G     + L+Q G+  + ++    TPLH+AAR GH  +   L+ N A    +  
Sbjct: 409 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 468

Query: 371 HDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAA 430
            D  PLH A   G ++  + LL +                    + N     G T LH A
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNA------------------NPNLATTAGHTPLHIA 510

Query: 431 ASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGC 490
           A  G+VE +  LL   A      K G TPLH AA  G  + A  L+   A  N A   G 
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570

Query: 491 SPLHYAAASDTY--------RRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGAD 542
           +PLH A   +          R   PH+P+ +      PL  + ++        LL  G  
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY---TPLHIAAKQNQVEVARSLLQYGGS 627

Query: 543 PSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALK 602
            +    QG T +H AA  G+ + + LLL    N   ++ +   ++PLHL A  GH     
Sbjct: 628 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN--GNLGNKSGLTPLHLVAQEGHVPVAD 685

Query: 603 TLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS 662
            L +  V +D     G T L +A+  G+ + V+ L  H A    K  K  ++PLH AA  
Sbjct: 686 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK-TKLGYSPLHQAAQQ 744

Query: 663 GHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLL 707
           GHTD + LL+ +G      + + + G TPL +A   G++    +L
Sbjct: 745 GHTDIVTLLLKNGAS---PNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  283 bits (725), Expect = 5e-76
 Identities = 249/854 (29%), Positives = 379/854 (44%), Gaps = 76/854 (8%)

Query: 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKL 191
           S+   +    ++   A  SG+L+     L  G  +N C++     LH A+  GH++++  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 192 LVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQ 251
           L+ +   L    +KG   LH AA +GQ EVV+ L+  GA ++  +  G T L++A     
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 252 DAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGK---S 308
             V   L+  GAN N   + GFTPL VA    +  +   L       +NY +K GK    
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL-------INYGTK-GKVRLP 175

Query: 309 PLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARR 368
            LH+AA +     + +L+QN    D   K G TPLH+AA Y +  +   L+  GA     
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 369 GIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLH 428
             + + PLH+A   G     R LL  G                A  +  T D L  T LH
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRG----------------AQIETKTKDEL--TPLH 277

Query: 429 AAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCK 488
            AA  G+V    +LL  GA ++ + K G +P+H AA      C   L+   A +++    
Sbjct: 278 CAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD 337

Query: 489 GCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDR 548
             +PLH AA    +R A                            + LLD GA P+ R  
Sbjct: 338 HLTPLHVAAHCGHHRVA----------------------------KVLLDKGAKPNSRAL 369

Query: 549 QGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETL 608
            G+T +H A    + + +ELLL+   +   D  +   ++PLH+A++ GH   +K L +  
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASI--DAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 609 VNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSL 668
            + +V + K  T L +A   G TE  + L  + A    K  K   TPLH AA  GHT+ +
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK-AKDDQTPLHCAARIGHTNMV 486

Query: 669 HLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRG 728
            LL+++    ++       G TPL +A   GHV+ V  LLEK ++      +G T LH  
Sbjct: 487 KLLLENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543

Query: 729 AVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVD 788
           A  G       LL+ DA        G TP+H+A    +  +++ LL    S         
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH----SPA 599

Query: 789 YSGYSPMHWASYTGHEDCLELLLEHSPFSYLEG-NPFTPLHCAVINNQDSTTEMLLGALG 847
           ++GY+P+H A+     +    LL++   +  E     TPLH A    Q+   EM+   L 
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA---QEGHAEMVALLLS 656

Query: 848 AKI-VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAA 906
            +   N  +  G TPLH  A   +V    +L++H   V+AT   G T L  A+  G    
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 907 VEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLH 966
           V+FLL + +AD+    +   + LH A  +GH     ++L   ++    N  +S    PL 
Sbjct: 717 VKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL---KNGASPNEVSSDGTTPLA 772

Query: 967 IAARNGLASVVQAL 980
           IA R G  SV   L
Sbjct: 773 IAKRLGYISVTDVL 786



 Score =  278 bits (712), Expect = 2e-74
 Identities = 246/847 (29%), Positives = 369/847 (43%), Gaps = 86/847 (10%)

Query: 76  TPLHRAAASRN-EKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLN 134
           T   RAA S N +K L  L  +  D+N  ++     LH+A+     K    L      L 
Sbjct: 14  TSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72

Query: 135 VADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVA 194
              + G +ALH A  +G  E V  L+N GA++N   +K   PL+ AA   HLEV+K L+ 
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 195 RGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAV 254
            GA+       G+  L  A   G   VV +L+  G +          ALHIA        
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRT 188

Query: 255 AIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAA 314
           A  L+    N +  +  GFTPLH+AA   N  +  +LL+N GA VN+  + G +PLH+A+
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA-QLLLNRGASVNFTPQNGITPLHIAS 247

Query: 315 IHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMF 374
             G     ++L+  G++I+   K   TPLH AAR GH  +   L+ +GA    +  + + 
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 375 PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434
           P+H+A      DC R LL                   A  D  T D+L  T LH AA  G
Sbjct: 308 PIHMAAQGDHLDCVRLLLQ----------------YDAEIDDITLDHL--TPLHVAAHCG 349

Query: 435 NVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLH 494
           +     +LL  GA    R   G TPLH A      +    L+  GA ++     G +PLH
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 409

Query: 495 YAA-------ASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRD 547
            A+         +  +R    +P+  + + + PL  + R       ++LL N A  + + 
Sbjct: 410 VASFMGHLPIVKNLLQRGA--SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 548 RQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAET 607
           +   T +H AA  G+   ++LLLE + N   ++ +T   +PLH+AA  GH E +  L E 
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNAN--PNLATTAGHTPLHIAAREGHVETVLALLEK 525

Query: 608 LVNLDVRDHKGRTALFLATERGSTECVEVL---TAHGASALIKERKRKWTPLHAAAASGH 664
             +      KG T L +A + G     E+L    AH  +A     K   TPLH A    +
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA----GKNGLTPLHVAVHHNN 581

Query: 665 TDSLHLLIDSGERADITDVMDAY-GQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRT 723
            D + LL+  G     +    A+ G TPL +A     V+    LL+ G +A+A  ++G T
Sbjct: 582 LDIVKLLLPRGG----SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637

Query: 724 ALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPL 783
            LH  A  G  + +A LL   A     +  G TP+HL +  GH  V   L++  +  D  
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD-- 695

Query: 784 DAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLL 843
                  GY+P+H AS+ G+   ++ LL+H                              
Sbjct: 696 --ATTRMGYTPLHVASHYGNIKLVKFLLQHQ----------------------------- 724

Query: 844 GALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQ 903
                  VN++   G +PLH AA   +   + +LL++ A  N     G T L  A   G 
Sbjct: 725 -----ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779

Query: 904 TAAVEFL 910
            +  + L
Sbjct: 780 ISVTDVL 786



 Score =  256 bits (655), Expect = 6e-68
 Identities = 201/684 (29%), Positives = 311/684 (45%), Gaps = 31/684 (4%)

Query: 10  PPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNA 69
           P L  A  + D      LL    N +VL +   TPLH AA+  ++ + QLLL  GA+VN 
Sbjct: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234

Query: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
                +TPLH A+   N  ++ LLL   A +  + K   TPLH AA N   + +E L   
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294

Query: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL 189
            + +    ++G S +H A    HL+ V LLL   A ++        PLH AA  GH  V 
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354

Query: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYL 249
           K+L+ +GA    +   G+  LH A     + V++ LL+ GA ID     G T LH+A ++
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414

Query: 250 GQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSP 309
           G   +   L+  GA+ N  N K  TPLH+AA + +  +  + L+ N A VN ++K+ ++P
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTP 473

Query: 310 LHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRG 369
           LH AA  G     ++L++N +  + A   G+TPLH+AAR GH   +  L+   A  A   
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533

Query: 370 IHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHA 429
                PLH+A  +G       LL             + H  +AG +       G T LH 
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLE-----------RDAHPNAAGKN-------GLTPLHV 575

Query: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 489
           A    N++ + LLL  G         G TPLH AA     + A +L+  G   N    +G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635

Query: 490 CSPLHYAAASD-----TYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544
            +PLH AA            ++    +  +     PL    ++      + L+ +G    
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695

Query: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTL 604
              R GYT +H A+ YGN + ++ LL+   +   + ++ +  SPLH AA  GH + +  L
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVTLL 753

Query: 605 AETLVNLDVRDHKGRTALFLATERG---STECVEVLTAHGASALIKERKRKWTP--LHAA 659
            +   + +     G T L +A   G    T+ ++V+T   +  L+ ++ R   P  +   
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEI 813

Query: 660 AASGHTDSLHLLIDSGERADITDV 683
                 +   L+    ER D  DV
Sbjct: 814 LDVSEDEGEELISFKAERRDSRDV 837



 Score =  197 bits (501), Expect = 4e-50
 Identities = 182/627 (29%), Positives = 269/627 (42%), Gaps = 32/627 (5%)

Query: 394  SGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRD 453
            SG L   +  L N      G DINT +  G   LH A+  G+V+ +  LL     L    
Sbjct: 22   SGNLDKALDHLRN------GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75

Query: 454  KFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE---PHTP 510
            K G T LH AA  G  +    LV  GA VN    KG +PL+ AA  +     +    +  
Sbjct: 76   KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135

Query: 511  SSHDAEED--EPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLEL 568
            + + A ED   PL  + ++     +  L++ G    +R      A+H AA   + +   +
Sbjct: 136  NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAV 191

Query: 569  LLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATER 628
            LL+   N   DV S    +PLH+AA+  +    + L     +++     G T L +A+ R
Sbjct: 192  LLQNDPN--PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249

Query: 629  GSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYG 688
            G+   V +L   GA    K  K + TPLH AA +GH     +L+D G            G
Sbjct: 250  GNVIMVRLLLDRGAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQ---AKTKNG 305

Query: 689  QTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVL 748
             +P+ +A    H+DCV LLL+  +  D   L   T LH  A  G       LLD  A   
Sbjct: 306  LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 749  CRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLE 808
             R   G TP+H+A    H  V+  LL+   S D     V  SG +P+H AS+ GH   ++
Sbjct: 366  SRALNGFTPLHIACKKNHVRVMELLLKTGASID----AVTESGLTPLHVASFMGHLPIVK 421

Query: 809  LLLEHSPFSYLEGNPF-TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAF 867
             LL+      +      TPLH A         + LL       VN++    +TPLH AA 
Sbjct: 422  NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK--VNAKAKDDQTPLHCAAR 479

Query: 868  ADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNT 927
              + + +++LL++ A  N     G T L  AA  G    V  LL + +A    + +   T
Sbjct: 480  IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK-EASQACMTKKGFT 538

Query: 928  ALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATV 987
             LH+A   G  + A ++L         NA       PLH+A  +    +V+ LL  G + 
Sbjct: 539  PLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595

Query: 988  LAVDEEGHTPALACAPNKDVADCLALI 1014
             +    G+TP    A    V    +L+
Sbjct: 596  HSPAWNGYTPLHIAAKQNQVEVARSLL 622



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 6/148 (4%)

Query: 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910
           V  R+A   T    AA + N+      L++  ++N  +  G   L  A++ G    V  L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 911 LYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGL-INATNSALQMPLHIAA 969
           L++ +  L    +  NTALH+A   G ++    ++ E  + G  +NA +     PL++AA
Sbjct: 65  LHK-EIILETTTKKGNTALHIAALAGQDE----VVRELVNYGANVNAQSQKGFTPLYMAA 119

Query: 970 RNGLASVVQALLSHGATVLAVDEEGHTP 997
           +     VV+ LL +GA      E+G TP
Sbjct: 120 QENHLEVVKFLLENGANQNVATEDGFTP 147



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 35/111 (31%), Positives = 55/111 (49%), Gaps = 6/111 (5%)

Query: 893  TALMTAAENGQT-AAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDL 951
            T+ + AA +G    A++ L  R   D+   ++N    LHLA  +GH K  + +L +    
Sbjct: 14   TSFLRAARSGNLDKALDHL--RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI-- 69

Query: 952  GLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002
             ++  T       LHIAA  G   VV+ L+++GA V A  ++G TP    A
Sbjct: 70   -ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  291 bits (746), Expect = 2e-78
 Identities = 235/797 (29%), Positives = 360/797 (45%), Gaps = 42/797 (5%)

Query: 147 AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKG 206
           A  +GHLE     +  G  +N+C++     LH A+  GH+EV+  L+ R A++    +KG
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107

Query: 207 YGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266
              LH A+ +GQ EVVK L+  GA ++  +  G T L++A       V   L++ GA+ +
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167

Query: 267 QPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI 326
              + GFTPL VA    +  +   LL N     + + K     LH+AA       + +L+
Sbjct: 168 LATEDGFTPLAVALQQGHDQVVSLLLEN-----DTKGKVRLPALHIAARKDDTKAAALLL 222

Query: 327 QNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSD 386
           QN +  D   K G TPLH+AA YG+  + + L+   A       +D+ PLH+A   G ++
Sbjct: 223 QNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNAN 282

Query: 387 CCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSG 446
             + LL  G                A  D  T D  G T LH  A  G+ + + +LL   
Sbjct: 283 MVKLLLDRG----------------AKIDAKTRD--GLTPLHCGARSGHEQVVEMLLDRA 324

Query: 447 ADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRA- 505
           A +  + K G +PLH A       C   L+     V++      + LH AA    Y+ A 
Sbjct: 325 APILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAK 384

Query: 506 ----EPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYG 561
               +   P++       PL  + +K     +E LL +GA        G T +H AA  G
Sbjct: 385 VLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMG 444

Query: 562 NRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTA 621
           +   +  L  M      +  +    + LH+AA +G  E ++ L +    ++ +    +T 
Sbjct: 445 HVNIVSQL--MHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502

Query: 622 LFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADIT 681
           L ++   G  + V+ L   GAS         +TPLH +A  GH D    L+D G    IT
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTS-GYTPLHLSAREGHEDVAAFLLDHGASLSIT 561

Query: 682 DVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALL 741
                 G TPL +A   G ++  +LLL+K ++ DAA   G T LH  A    +     LL
Sbjct: 562 ---TKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLL 618

Query: 742 DHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYT 801
           D  A        G TP+H+A+      +  TLL+     +     V   G + +H A+  
Sbjct: 619 DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN----AVTRQGIASVHLAAQE 674

Query: 802 GHEDCLELLL-EHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRT 860
           GH D + LLL  ++  +    +  TPLH A   ++ +  E+L+   GA  V+++   G T
Sbjct: 675 GHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQ-GAH-VDAQTKMGYT 732

Query: 861 PLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTV 920
           PLH      N+  +  LLQH A+VNA    G T L  AA+ G T  +  LL +  A    
Sbjct: 733 PLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL-QNNASPNE 791

Query: 921 LDENKNTALHLACSKGH 937
           L  N NTAL +A   G+
Sbjct: 792 LTVNGNTALGIARRLGY 808



 Score =  275 bits (703), Expect = 2e-73
 Identities = 228/779 (29%), Positives = 348/779 (44%), Gaps = 56/779 (7%)

Query: 21  VEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHR 80
           +E+    +    +IN+ +Q     LH A+  G V ++  LL   ANV+A      T LH 
Sbjct: 54  LEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHI 113

Query: 81  AAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSG 140
           A+ +   +V+ +L+ + A+VNA+ +   TPL++AA     +  + L    +S ++A   G
Sbjct: 114 ASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDG 173

Query: 141 RSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP-LHWAAFLGHLEVLKLLVARGADL 199
            + L  A+  GH + V+LLL      N    K R P LH AA     +   LL+    + 
Sbjct: 174 FTPLAVALQQGHDQVVSLLLE-----NDTKGKVRLPALHIAARKDDTKAAALLLQNDNNA 228

Query: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV 259
             + + G+  LH AA  G I V   LL   A +D       T LH+A   G   +   L+
Sbjct: 229 DVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLL 288

Query: 260 NAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRF 319
           + GA ++     G TPLH  A S +  + +E+L++  A +  ++K G SPLHMA      
Sbjct: 289 DRGAKIDAKTRDGLTPLHCGARSGHEQV-VEMLLDRAAPILSKTKNGLSPLHMATQGDHL 347

Query: 320 TRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLA 379
              Q+L+Q+   +D       T LHVAA  GH  +   L+   A+   + ++   PLH+A
Sbjct: 348 NCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIA 407

Query: 380 VLFGFSDCCRKLLSSGQLYSIV--SSLSNEHV-------------LSAGFDINTPDNLGR 424
                      LL  G     V  S L+  HV             +  G   NT +  G 
Sbjct: 408 CKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGE 467

Query: 425 TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE 484
           T LH AA  G  E +  L+  GA +  + K  +TPLH +A  G       L+  GA  N 
Sbjct: 468 TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527

Query: 485 ADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544
           A   G +PLH                S+ +  ED                FLLD+GA  S
Sbjct: 528 ATTSGYTPLHL---------------SAREGHED-------------VAAFLLDHGASLS 559

Query: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTL 604
           +  ++G+T +H AA YG  +   LLL+ S +   D      ++PLH+AA+  + +    L
Sbjct: 560 ITTKKGFTPLHVAAKYGKLEVANLLLQKSAS--PDAAGKSGLTPLHVAAHYDNQKVALLL 617

Query: 605 AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGH 664
            +   +       G T L +A ++   +    L  +GA A    R +    +H AA  GH
Sbjct: 618 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTR-QGIASVHLAAQEGH 676

Query: 665 TDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTA 724
            D + LL+  G  A++ ++ +  G TPL LA     V+   +L+ +G+  DA    G T 
Sbjct: 677 VDMVSLLL--GRNANV-NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTP 733

Query: 725 LHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPL 783
           LH G   G    +  LL H A V  +   G TP+H A+  GHT ++  LLQ   S + L
Sbjct: 734 LHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 792



 Score =  275 bits (703), Expect = 2e-73
 Identities = 219/757 (28%), Positives = 334/757 (44%), Gaps = 98/757 (12%)

Query: 21  VEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHR 80
           VE V  LL ++ N++   ++  T LH A+  G   ++++L+ +GANVNA+     TPL+ 
Sbjct: 87  VEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYM 146

Query: 81  AAASRNEKVLGLLLAHSADVNARDKLWQTPL----------------------------- 111
           AA   + +V+  LL + A  +   +   TPL                             
Sbjct: 147 AAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPAL 206

Query: 112 HVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDK 171
           H+AA    TK A  L    ++ +V  +SG + LH A H G++    LLLN+ A+++   +
Sbjct: 207 HIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTAR 266

Query: 172 KERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAE 231
            +  PLH A+  G+  ++KLL+ RGA +  K R G   LH  A SG  +VV+ LL   A 
Sbjct: 267 NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326

Query: 232 I---------------------------------DEPNAFGNTALHIACYLGQDAVAIEL 258
           I                                 D+      TALH+A + G   VA  L
Sbjct: 327 ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386

Query: 259 VNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGR 318
           ++  AN N     GFTPLH+A    N    +ELL+ +GA +   ++ G +P+H+AA  G 
Sbjct: 387 LDKKANPNAKALNGFTPLHIAC-KKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGH 445

Query: 319 FTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHL 378
                 L+ +G+  +  +  G T LH+AAR G   ++  L+ +GA    +   D  PLH+
Sbjct: 446 VNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHI 505

Query: 379 AVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVEC 438
           +   G +D  ++LL  G                     N     G T LH +A  G+ + 
Sbjct: 506 SARLGKADIVQQLLQQGA------------------SPNAATTSGYTPLHLSAREGHEDV 547

Query: 439 LNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAA 498
              LL  GA L    K G TPLH AA  G  + A  L+   A  + A   G +PLH AA 
Sbjct: 548 AAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAH 607

Query: 499 SDTYR--------RAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQG 550
            D  +         A PH  + +      PL  + +K        LL+ GAD +   RQG
Sbjct: 608 YDNQKVALLLLDQGASPHAAAKNGY---TPLHIAAKKNQMDIATTLLEYGADANAVTRQG 664

Query: 551 YTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVN 610
             +VH AA  G+   + LLL  + N   ++ +   ++PLHLAA        + L     +
Sbjct: 665 IASVHLAAQEGHVDMVSLLLGRNANV--NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAH 722

Query: 611 LDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHL 670
           +D +   G T L +    G+ + V  L  H A    K  K  +TPLH AA  GHT  +++
Sbjct: 723 VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAK-TKNGYTPLHQAAQQGHTHIINV 781

Query: 671 LIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLL 707
           L+ +       + +   G T L +A   G++  V  L
Sbjct: 782 LLQNNAS---PNELTVNGNTALGIARRLGYISVVDTL 815



 Score =  270 bits (690), Expect = 5e-72
 Identities = 234/792 (29%), Positives = 363/792 (45%), Gaps = 49/792 (6%)

Query: 213 AAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272
           AA +G +E     ++ G +I+  N  G  ALH+A   G   V  EL+   ANV+    KG
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107

Query: 273 FTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEI 332
            T LH+A+++    + +++LV NGA+VN QS+ G +PL+MAA        + L+ NG+  
Sbjct: 108 NTALHIASLAGQAEV-VKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQ 166

Query: 333 DCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLL 392
             A + G TPL VA + GH+ ++S L+ N  DT  +G   +  LH+A     +     LL
Sbjct: 167 SLATEDGFTPLAVALQQGHDQVVSLLLEN--DT--KGKVRLPALHIAARKDDTKAAALLL 222

Query: 393 SSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRR 452
            +     + S         +GF          T LH AA  GN+    LLL+  A +   
Sbjct: 223 QNDNNADVESK--------SGF----------TPLHIAAHYGNINVATLLLNRAAAVDFT 264

Query: 453 DKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYR-------RA 505
            +   TPLH A+  G+      L+  GA ++     G +PLH  A S   +       RA
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324

Query: 506 EPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQN 565
            P    + +     PL  + + +   C++ LL +            TA+H AA  G+ + 
Sbjct: 325 APILSKTKNGLS--PLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKV 382

Query: 566 LELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLA 625
            ++LL+   N   + ++    +PLH+A      + ++ L +   ++      G T + +A
Sbjct: 383 AKVLLDKKAN--PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVA 440

Query: 626 TERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMD 685
              G    V  L  HGAS      + + T LH AA SG  + +  L+  G + +     D
Sbjct: 441 AFMGHVNIVSQLMHHGASPNTTNVRGE-TALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499

Query: 686 AYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDA 745
              QTPL ++   G  D V  LL++G++ +AA   G T LH  A  G ED  A LLDH A
Sbjct: 500 ---QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGA 556

Query: 746 FVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHED 805
            +     KG TP+H+A+  G   V   LLQ + S D        SG +P+H A++  ++ 
Sbjct: 557 SLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD----AAGKSGLTPLHVAAHYDNQK 612

Query: 806 CLELLLEHSPFSYLEG-NPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHA 864
              LLL+     +    N +TPLH A   NQ      LL   GA   N+   +G   +H 
Sbjct: 613 VALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL-EYGAD-ANAVTRQGIASVHL 670

Query: 865 AAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDEN 924
           AA   +V  + +LL   A VN ++ +G T L  AA+  +    E L+ +G A +    + 
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG-AHVDAQTKM 729

Query: 925 KNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHG 984
             T LH+ C  G+ K    +L   Q    +NA       PLH AA+ G   ++  LL + 
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLL---QHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNN 786

Query: 985 ATVLAVDEEGHT 996
           A+   +   G+T
Sbjct: 787 ASPNELTVNGNT 798



 Score =  264 bits (674), Expect = 4e-70
 Identities = 226/798 (28%), Positives = 336/798 (42%), Gaps = 97/798 (12%)

Query: 180 AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFG 239
           AA  GHLE     +  G D+   ++ G   LH A+  G +EVV  LL+  A +D     G
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107

Query: 240 NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299
           NTALHIA   GQ  V   LV  GANVN  +  GFTPL++AA   N    ++ L++NGA  
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAA-QENHLEVVKFLLDNGASQ 166

Query: 300 NYQSKEGKSPL-----------------------------HMAAIHGRFTRSQILIQNGS 330
           +  +++G +PL                             H+AA       + +L+QN +
Sbjct: 167 SLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDN 226

Query: 331 EIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRK 390
             D   K G TPLH+AA YG+  + + L+   A       +D+ PLH+A   G ++  + 
Sbjct: 227 NADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKL 286

Query: 391 LLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLR 450
           LL  G                A  D  T D L  T LH  A  G+ + + +LL   A + 
Sbjct: 287 LLDRG----------------AKIDAKTRDGL--TPLHCGARSGHEQVVEMLLDRAAPIL 328

Query: 451 RRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE---- 506
            + K G +PLH A       C   L+     V++      + LH AA    Y+ A+    
Sbjct: 329 SKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLD 388

Query: 507 -PHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQN 565
               P++       PL  + +K     +E LL +GA        G T +H AA  G+   
Sbjct: 389 KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448

Query: 566 LELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLA 625
           +  L  M      +  +    + LH+AA +G  E ++ L +    ++ +    +T L ++
Sbjct: 449 VSQL--MHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHIS 506

Query: 626 TERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMD 685
              G  + V+ L   GAS         +TPLH +A  GH D    L+D G    IT    
Sbjct: 507 ARLGKADIVQQLLQQGASPNAATTSG-YTPLHLSAREGHEDVAAFLLDHGASLSITTKK- 564

Query: 686 AYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDA 745
             G TPL +A   G ++  +LLL+K ++ DAA   G T LH  A    +     LLD  A
Sbjct: 565 --GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGA 622

Query: 746 FVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHED 805
                   G TP+H+A+      +  TLL+     +     V   G + +H A+  GH D
Sbjct: 623 SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN----AVTRQGIASVHLAAQEGHVD 678

Query: 806 CLELLLEHSPFSYLEGNP-FTPLHCAVINNQDSTTEMLLGALGAKI-------------- 850
            + LLL  +    L      TPLH A   ++ +  E+L+   GA +              
Sbjct: 679 MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQ-GAHVDAQTKMGYTPLHVG 737

Query: 851 ------------------VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGR 892
                             VN++   G TPLH AA   +   + +LLQ+ A  N     G 
Sbjct: 738 CHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGN 797

Query: 893 TALMTAAENGQTAAVEFL 910
           TAL  A   G  + V+ L
Sbjct: 798 TALGIARRLGYISVVDTL 815



 Score =  258 bits (658), Expect = 3e-68
 Identities = 204/717 (28%), Positives = 326/717 (45%), Gaps = 56/717 (7%)

Query: 293 VNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHE 352
           + NG D+N  ++ G + LH+A+  G       L+Q  + +D A K GNT LH+A+  G  
Sbjct: 61  IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQA 120

Query: 353 LLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSS--------- 403
            ++  L+TNGA+   +  +   PL++A      +  + LL +G   S+ +          
Sbjct: 121 EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180

Query: 404 --LSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLH 461
               ++ V+S   + +T   +    LH AA   + +   LLL +  +     K G TPLH
Sbjct: 181 LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLH 240

Query: 462 YAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPL 521
            AA  G+   A  L+   A V+       +PLH A                         
Sbjct: 241 IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVA------------------------- 275

Query: 522 KESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVE 581
             S+R  A   ++ LLD GA    + R G T +H  A  G+ Q +E+LL+ +   L   +
Sbjct: 276 --SKRGNANM-VKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTK 332

Query: 582 STIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHG 641
           + +  SPLH+A    H   ++ L +  V +D   +   TAL +A   G  +  +VL    
Sbjct: 333 NGL--SPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKK 390

Query: 642 ASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHV 701
           A+   K     +TPLH A        + LL+  G  A I  V ++ G TP+ +A   GHV
Sbjct: 391 ANPNAKALNG-FTPLHIACKKNRIKVMELLLKHG--ASIQAVTES-GLTPIHVAAFMGHV 446

Query: 702 DCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLA 761
           + V  L+  G++ +  ++RG TALH  A +G  + +  L+   A V  +    +TP+H++
Sbjct: 447 NIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHIS 506

Query: 762 SACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPFSYLE 820
           +  G   +++ LLQ   S +        SGY+P+H ++  GHED    LL+H +  S   
Sbjct: 507 ARLGKADIVQQLLQQGASPNAATT----SGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562

Query: 821 GNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQH 880
              FTPLH A    +     +LL    +   ++    G TPLH AA  DN     +LL  
Sbjct: 563 KKGFTPLHVAAKYGKLEVANLLLQKSASP--DAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620

Query: 881 QAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKC 940
            A  +A    G T L  AA+  Q      LL  G AD   +      ++HLA  +GH   
Sbjct: 621 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG-ADANAVTRQGIASVHLAAQEGHVDM 679

Query: 941 ALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
             ++L    +   +N +N +   PLH+AA+    +V + L++ GA V A  + G+TP
Sbjct: 680 VSLLLGRNAN---VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTP 733



 Score =  249 bits (637), Expect = 8e-66
 Identities = 191/639 (29%), Positives = 291/639 (45%), Gaps = 38/639 (5%)

Query: 10  PPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNA 69
           P L  A    D +    LL    N +V  +   TPLH AA+ G++ +  LLL   A V+ 
Sbjct: 204 PALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDF 263

Query: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
                +TPLH A+   N  ++ LLL   A ++A+ +   TPLH  A +   +  E L   
Sbjct: 264 TARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDR 323

Query: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL 189
            + +    ++G S LH A    HL  V LLL     ++         LH AA  GH +V 
Sbjct: 324 AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVA 383

Query: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYL 249
           K+L+ + A+   K   G+  LH A    +I+V++ LL+ GA I      G T +H+A ++
Sbjct: 384 KVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFM 443

Query: 250 GQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSP 309
           G   +  +L++ GA+ N  N +G T LH+AA S   A  +  LV +GA V  ++K+ ++P
Sbjct: 444 GHVNIVSQLMHHGASPNTTNVRGETALHMAARS-GQAEVVRYLVQDGAQVEAKAKDDQTP 502

Query: 310 LHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRG 369
           LH++A  G+    Q L+Q G+  + A   G TPLH++AR GHE + + L+ +GA  +   
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562

Query: 370 IHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGR---TC 426
                PLH+A  +G  +    LL                         +PD  G+   T 
Sbjct: 563 KKGFTPLHVAAKYGKLEVANLLLQKSA---------------------SPDAAGKSGLTP 601

Query: 427 LHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEAD 486
           LH AA   N +   LLL  GA      K G TPLH AA       A TL+  GA  N   
Sbjct: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661

Query: 487 CKGCSPLHYAAASDTY--------RRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLD 538
            +G + +H AA             R A  +  +        PL  + +++     E L++
Sbjct: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL---TPLHLAAQEDRVNVAEVLVN 718

Query: 539 NGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHC 598
            GA    + + GYT +H    YGN + +  LL+ S     + ++    +PLH AA  GH 
Sbjct: 719 QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKV--NAKTKNGYTPLHQAAQQGHT 776

Query: 599 EALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVL 637
             +  L +   + +     G TAL +A   G    V+ L
Sbjct: 777 HIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815



 Score =  239 bits (611), Expect = 8e-63
 Identities = 168/564 (29%), Positives = 263/564 (46%), Gaps = 47/564 (8%)

Query: 8   DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67
           D  PL  A    +   V+ LL +   I+   ++  TPLH  A  G   ++++LL   A +
Sbjct: 268 DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327

Query: 68  NAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALA 127
            +K    L+PLH A    +   + LLL H+  V+     + T LHVAA     K A+ L 
Sbjct: 328 LSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLL 387

Query: 128 PLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLE 187
              ++ N    +G + LH A     ++ + LLL  GAS+    +    P+H AAF+GH+ 
Sbjct: 388 DKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN 447

Query: 188 VLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIAC 247
           ++  L+  GA     + +G   LH AA SGQ EVV+YL++ GA+++       T LHI+ 
Sbjct: 448 IVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISA 507

Query: 248 YLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGK 307
            LG+  +  +L+  GA+ N     G+TPLH++A   +  +    L+++GA ++  +K+G 
Sbjct: 508 RLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA-AFLLDHGASLSITTKKGF 566

Query: 308 SPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTAR 367
           +PLH+AA +G+   + +L+Q  +  D A K G TPLHVAA Y ++ +   L+  GA    
Sbjct: 567 TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA 626

Query: 368 RGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCL 427
              +   PLH+A      D    LL  G                   D N     G   +
Sbjct: 627 AAKNGYTPLHIAAKKNQMDIATTLLEYGA------------------DANAVTRQGIASV 668

Query: 428 HAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADC 487
           H AA  G+V+ ++LLL   A++   +K G TPLH AA       A  LV  GA V+    
Sbjct: 669 HLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 728

Query: 488 KGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRD 547
            G +PLH        +                             + FLL + A  + + 
Sbjct: 729 MGYTPLHVGCHYGNIK----------------------------IVNFLLQHSAKVNAKT 760

Query: 548 RQGYTAVHYAAAYGNRQNLELLLE 571
           + GYT +H AA  G+   + +LL+
Sbjct: 761 KNGYTPLHQAAQQGHTHIINVLLQ 784



 Score =  185 bits (470), Expect = 2e-46
 Identities = 122/354 (34%), Positives = 179/354 (50%), Gaps = 1/354 (0%)

Query: 5   SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSG 64
           ++  +  L  A  S   E VR L+     +    ++ +TPLH +A +G   I+Q LL  G
Sbjct: 463 NVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQG 522

Query: 65  ANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAE 124
           A+ NA  T   TPLH +A   +E V   LL H A ++   K   TPLHVAA     + A 
Sbjct: 523 ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVAN 582

Query: 125 ALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLG 184
            L    +S + A +SG + LH A H  + +   LLL++GAS +   K    PLH AA   
Sbjct: 583 LLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN 642

Query: 185 HLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALH 244
            +++   L+  GAD     R+G   +H AA  G +++V  LL   A ++  N  G T LH
Sbjct: 643 QMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLH 702

Query: 245 IACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSK 304
           +A    +  VA  LVN GA+V+     G+TPLHV     N  + +  L+ + A VN ++K
Sbjct: 703 LAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKI-VNFLLQHSAKVNAKTK 761

Query: 305 EGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
            G +PLH AA  G      +L+QN +  +     GNT L +A R G+  ++ TL
Sbjct: 762 NGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815



 Score =  181 bits (460), Expect = 3e-45
 Identities = 153/572 (26%), Positives = 248/572 (43%), Gaps = 50/572 (8%)

Query: 537  LDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNG 596
            + NG D ++ ++ G  A+H A+  G+ + +  LL+   N   D  +    + LH+A+  G
Sbjct: 61   IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANV--DAATKKGNTALHIASLAG 118

Query: 597  HCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPL 656
              E +K L     N++ +   G T L++A +    E V+ L  +GAS  +      +TPL
Sbjct: 119  QAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDG-FTPL 177

Query: 657  HAAAASGHTDSLHLLIDSGERADI--------------------------TDVMDAYGQT 690
              A   GH   + LL+++  +  +                           DV    G T
Sbjct: 178  AVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFT 237

Query: 691  PLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCR 750
            PL +A   G+++   LLL + +  D       T LH  +  G  + +  LLD  A +  +
Sbjct: 238  PLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAK 297

Query: 751  DFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL 810
               G TP+H  +  GH  V+  LL  A            +G SP+H A+   H +C++LL
Sbjct: 298  TRDGLTPLHCGARSGHEQVVEMLLDRAAPI----LSKTKNGLSPLHMATQGDHLNCVQLL 353

Query: 811  LEHS-PFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFAD 869
            L+H+ P   +  +  T LH A         ++LL        N++   G TPLH A   +
Sbjct: 354  LQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANP--NAKALNGFTPLHIACKKN 411

Query: 870  NVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTAL 929
             +  + +LL+H A + A   +G T +  AA  G    V  L++ G +  T  +    TAL
Sbjct: 412  RIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTT-NVRGETAL 470

Query: 930  HLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLA 989
            H+A   G  +    ++   QD   + A     Q PLHI+AR G A +VQ LL  GA+  A
Sbjct: 471  HMAARSGQAEVVRYLV---QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527

Query: 990  VDEEGHTPALACA--PNKDVADCL-----ALILSTMKPFPPKDAVSPFSFSLLKNCSI-- 1040
                G+TP    A   ++DVA  L     +L ++T K F P    + +    + N  +  
Sbjct: 528  ATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587

Query: 1041 -AAAKTVGGCGALPHGASCPYSQERPGAIGLD 1071
             A+    G  G  P   +  Y  ++   + LD
Sbjct: 588  SASPDAAGKSGLTPLHVAAHYDNQKVALLLLD 619


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
          Length = 2352

 Score =  256 bits (654), Expect = 8e-68
 Identities = 272/980 (27%), Positives = 413/980 (42%), Gaps = 132/980 (13%)

Query: 7    TDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGAN 66
            +D   L +A    DV  VR LL +  ++N   +E  + L  A   G   + Q+LL   AN
Sbjct: 233  SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 292

Query: 67   VNAKDTLW-LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEA 125
            V  +     +TPL  AA   + K++ LLLAH ADVNA+     T L  A A       + 
Sbjct: 293  VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKV 352

Query: 126  LAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV-CDKKERQPLHWAAFLG 184
            L    +S+   + +G + L  A  +GH+E   LLL  GA +N   ++ +   L  A + G
Sbjct: 353  LLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKG 412

Query: 185  HLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALH 244
            HLE+++ L+  GAD   K  + +  L  A   G +EV + LL  GA+++ P     + L 
Sbjct: 413  HLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 472

Query: 245  IACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSK 304
            +A   G   +A  L+  GA++ + ND+G+TPL  AA   +  + + LL+  GA++N Q++
Sbjct: 473  LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM-VALLLGQGANINAQTE 531

Query: 305  E-GKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGA 363
            E  ++ L +A   G    +  LI+ G++I+      +TPL  AA+ GH  L+  L+  GA
Sbjct: 532  ETQETALTLACCGGFLEVADFLIKAGADIELG---CSTPLMEAAQEGHLELVKYLLAAGA 588

Query: 364  DTARRGIHDMFPLHLAVLFGFSDCCRKLL---------SSGQLYSIVSSLSNEHV----- 409
            +           L  A   G +D    LL         S G    ++ +    HV     
Sbjct: 589  NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648

Query: 410  -LSAGFDIN-TPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANG 467
             +S G ++N T  N   T L  A +GG++  + LLL+ GAD   R K G T L  AA  G
Sbjct: 649  LISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 708

Query: 468  SYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDE-------- 519
                   L+     +  A     + L               TP SHD             
Sbjct: 709  HTSVVCYLLDYPNNLLSAPPPDVTQL---------------TPPSHDLNRAPRVPVQALP 753

Query: 520  ---PLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVH-YAAAYGNRQNLELLLEMSFN 575
               P +E  +  A       + N A          T  H  AA+    Q       +S +
Sbjct: 754  MVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPS 813

Query: 576  CLEDVESTIPV---------SPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLAT 626
             +  +   I +         + L LA   GH E ++TL E   +++ RD KG T L LA 
Sbjct: 814  AMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAA 873

Query: 627  ERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMD- 685
              G    VE+L  +GA    +  + K TPL  A + G  + + LL+  G   +  +V D 
Sbjct: 874  TAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY 933

Query: 686  -------------------------------AYGQTPLMLAIMNGHVDCVHLLLEKGSTA 714
                                             G +PLMLA MNGH   V LLL+ GS  
Sbjct: 934  TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDI 993

Query: 715  DA-ADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTL 773
            +A  +    TAL      G  + ++ LLD  A V  R   G TP+  A++ G+  V R L
Sbjct: 994  NAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1053

Query: 774  LQ--AALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAV 831
            L   A ++  P+ +  D    + +  A+  GH    ELL+                    
Sbjct: 1054 LDKGADVNAPPVPSSRD----TALTIAADKGHYKFCELLI-------------------- 1089

Query: 832  INNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTG 891
                           GA I + R+ KG TPL  AA   ++  +++L+Q  A+V+A D+  
Sbjct: 1090 -------------GRGAHI-DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1135

Query: 892  RTALMTAAENGQTAAVEFLL 911
             T LM A   G    V +L+
Sbjct: 1136 ITPLMAAFRKGHVKVVRYLV 1155



 Score =  239 bits (610), Expect = 1e-62
 Identities = 268/998 (26%), Positives = 425/998 (42%), Gaps = 99/998 (9%)

Query: 63   SGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKC 122
            S AN    D      L  A +  +   +  LL     VN   +  ++ L +A +    + 
Sbjct: 226  STANAGQSDN---RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYEL 282

Query: 123  AEALAPLLSSLNVADRSGR---SALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHW 179
            A+ L  L    NV DR  +   + L  A + GH++ V LLL   A +N         L +
Sbjct: 283  AQVL--LAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTY 340

Query: 180  AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEID-EPNAF 238
            A   G+++V+K+L+  GA +   +  G+  L  A ++G +EV + LL  GA I+   N F
Sbjct: 341  ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF 400

Query: 239  GNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGAD 298
              +AL +ACY G   +   L+ AGA+     D+  T L  A +  +  +   LL+++GA 
Sbjct: 401  KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQ 459

Query: 299  VNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
            VN  +   +SPL +AA  G    + +LI+ G+ ++  +  G TPL  AAR GHE +++ L
Sbjct: 460  VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALL 519

Query: 359  MTNGAD-TARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSN----------- 406
            +  GA+  A+        L LA   GF +    L+ +G    +  S              
Sbjct: 520  LGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLEL 579

Query: 407  -EHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAA 465
             +++L+AG +++     G T L  A   G+ +  ++LL +GADL    + GRTPL  AA 
Sbjct: 580  VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639

Query: 466  NGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESR 525
             G       L++ GA VN              A++ +          H A          
Sbjct: 640  AGHVCTVQFLISKGANVNRT-----------TANNDHTVLSLACAGGHLA---------- 678

Query: 526  RKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLE----DVE 581
                   +E LL +GADP+ R + G T +  AA  G+   +  LL+   N L     DV 
Sbjct: 679  ------VVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVT 732

Query: 582  STIPVSPLHLAAYNGHCEAL----------KTLAETLVNLDVRDHKGRTALFLATERGST 631
               P S     A     +AL          K  A     L +R+             G  
Sbjct: 733  QLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNK---------AVSGRA 783

Query: 632  ECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTP 691
              +     H  +A I + +   TP    + S        ++      DI    ++   T 
Sbjct: 784  SAMSNTPTHSIAASISQPQTP-TPSPIISPSA-------MLPIYPAIDIDAQTESNHDTA 835

Query: 692  LMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRD 751
            L LA   GH + V  LLE+G++ +  D +G T L   A  G    +  LLD+ A +  + 
Sbjct: 836  LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 895

Query: 752  FKGR-TPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL 810
             + + TP+ LA + G   V+  LL    + +  +     S Y+P+  A+  G+ + +++L
Sbjct: 896  ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV----SDYTPLSLAASGGYVNIIKIL 951

Query: 811  LE-HSPFSYLEGNP--FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAF 867
            L   +  +   G+    +PL  A +N   +  ++LL  +G+ I    +    T L  A F
Sbjct: 952  LNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD-MGSDINAQIETNRNTALTLACF 1010

Query: 868  ADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTV--LDENK 925
                  + +LL  +A V     TG T LM AA  G       LL +G AD+    +  ++
Sbjct: 1011 QGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKG-ADVNAPPVPSSR 1069

Query: 926  NTALHLACSKGHEK-CALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHG 984
            +TAL +A  KGH K C L+I         I+  N     PL +AA  G   VVQ L+  G
Sbjct: 1070 DTALTIAADKGHYKFCELLIGRGAH----IDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1125

Query: 985  ATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFP 1022
            A V A D    TP +A A  K     +  ++  +  FP
Sbjct: 1126 ADVDAADNRKITPLMA-AFRKGHVKVVRYLVKEVNQFP 1162



 Score =  167 bits (424), Expect = 4e-41
 Identities = 203/771 (26%), Positives = 308/771 (39%), Gaps = 123/771 (15%)

Query: 12   LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD 71
            L++A     VE  R LL     +N+      +PL  AA  G V +  LL+  GA++   +
Sbjct: 438  LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN 497

Query: 72   TLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQ----------------------- 108
                TPL  AA   +E+++ LLL   A++NA+ +  Q                       
Sbjct: 498  DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAG 557

Query: 109  --------TPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLL 160
                    TPL  AA     +  + L    ++++    +G +AL +A  +GH +  ++LL
Sbjct: 558  ADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL 617

Query: 161  NKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLG-CKDRKGYGLLHTAAASGQI 219
              GA L    +  R PL  AA  GH+  ++ L+++GA++        + +L  A A G +
Sbjct: 618  QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL 677

Query: 220  EVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVA 279
             VV+ LL  GA+       G+T L  A   G  +V   L++   N+        T L   
Sbjct: 678  AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPP 737

Query: 280  AVSTNGA-----------------------LCLELLVNNGADVNYQSKEGKSPLHMAAIH 316
            +   N A                       +   L + N A     S    +P H  A  
Sbjct: 738  SHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAAS 797

Query: 317  ----GRFTRSQIL-------IQNGSEIDC-ADKFGNTPLHVAARYGHELLISTLMTNGAD 364
                   T S I+       I    +ID   +   +T L +A   GHE L+ TL+  GA 
Sbjct: 798  ISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGAS 857

Query: 365  TARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGR 424
               R      PL LA   G       LL +G      S  + +                 
Sbjct: 858  IEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD----------------- 900

Query: 425  TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE 484
            T L  A SGG  E + LLL+ GA+   R+    TPL  AA+ G       L+ AGA +N 
Sbjct: 901  TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 960

Query: 485  --ADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGAD 542
                  G SPL  AA +        HT +                     ++ LLD G+D
Sbjct: 961  RTGSKLGISPLMLAAMNG-------HTAA---------------------VKLLLDMGSD 992

Query: 543  PSLR-DRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEAL 601
             + + +    TA+  A   G  + + LLL+   N   +  +   ++PL  AA  G+ E  
Sbjct: 993  INAQIETNRNTALTLACFQGRTEVVSLLLDRKANV--EHRAKTGLTPLMEAASGGYAEVG 1050

Query: 602  KTLAE--TLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAA 659
            + L +    VN         TAL +A ++G  +  E+L   GA   ++ +K   TPL  A
Sbjct: 1051 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGN-TPLWLA 1109

Query: 660  AASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710
            A  GH D + LL+ +G  AD+ D  D    TPLM A   GHV  V  L+++
Sbjct: 1110 ANGGHLDVVQLLVQAG--ADV-DAADNRKITPLMAAFRKGHVKVVRYLVKE 1157



 Score =  133 bits (335), Expect = 8e-31
 Identities = 146/529 (27%), Positives = 225/529 (42%), Gaps = 47/529 (8%)

Query: 493 LHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYT 552
           L  AAA+ T  RAE  + ++    ++  L E+  +     +  LL  G   +    +G +
Sbjct: 212 LDEAAAALTRMRAE--STANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGES 269

Query: 553 AVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLD 612
            +  A + G  +  ++LL M  N +ED      ++PL  AA  GH + +K L     +++
Sbjct: 270 LLCLACSAGYYELAQVLLAMHAN-VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVN 328

Query: 613 VRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLI 672
            +   G TAL  A   G  + V+VL   GAS +    +   TPL  A ++GH +   LL+
Sbjct: 329 AQSSTGNTALTYACAGGYVDVVKVLLESGAS-IEDHNENGHTPLMEAGSAGHVEVARLLL 387

Query: 673 DSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTG 732
           ++G  A I    + + ++ L LA   GH++ V  LLE G+  +       TAL    + G
Sbjct: 388 ENG--AGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDG 445

Query: 733 CEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGY 792
             +    LLD  A V        +P+ LA+  GH  +   L++   S +     V+  GY
Sbjct: 446 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEE----VNDEGY 501

Query: 793 SPMHWASYTGHEDCLELLLEHSPF-------------------SYLEGNPF--------- 824
           +P+  A+  GHE+ + LLL                         +LE   F         
Sbjct: 502 TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE 561

Query: 825 ----TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQH 880
               TPL  A         + LL A GA  V++  A G T L  A    +     +LLQ 
Sbjct: 562 LGCSTPLMEAAQEGHLELVKYLLAA-GAN-VHATTATGDTALTYACENGHTDVADVLLQA 619

Query: 881 QAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKC 940
            A++      GRT LM AA  G    V+FL+ +G         N +T L LAC+ GH   
Sbjct: 620 GADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAV 679

Query: 941 ALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLA 989
             ++LA   D        S +   L  AA+ G  SVV  LL +   +L+
Sbjct: 680 VELLLAHGADPTHRLKDGSTM---LIEAAKGGHTSVVCYLLDYPNNLLS 725



 Score =  128 bits (321), Expect = 3e-29
 Identities = 119/394 (30%), Positives = 175/394 (44%), Gaps = 46/394 (11%)

Query: 5   SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSG 64
           S T    L  A     V+ V+ LL    +I   ++   TPL  A   G V + +LLL +G
Sbjct: 331 SSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENG 390

Query: 65  ANVNA----------------------------------KDTLWLTPLHRAAASRNEKVL 90
           A +N                                   K     T L  A    + +V 
Sbjct: 391 AGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 450

Query: 91  GLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHS 150
            LLL   A VN     +++PL +AA     + A  L    +SL   +  G + L  A   
Sbjct: 451 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAARE 510

Query: 151 GHLETVNLLLNKGASLNV-CDKKERQPLHWAAFLGHLEVLKLLVARGAD--LGCKDRKGY 207
           GH E V LLL +GA++N   ++ +   L  A   G LEV   L+  GAD  LGC      
Sbjct: 511 GHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTP--- 567

Query: 208 GLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQ 267
             L  AA  G +E+VKYLL  GA +    A G+TAL  AC  G   VA  L+ AGA++  
Sbjct: 568 --LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625

Query: 268 PNDKGFTPLHVAAVSTNGALC-LELLVNNGADVN-YQSKEGKSPLHMAAIHGRFTRSQIL 325
            ++ G TPL  AA +  G +C ++ L++ GA+VN   +    + L +A   G     ++L
Sbjct: 626 ESEGGRTPLMKAARA--GHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELL 683

Query: 326 IQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 359
           + +G++     K G+T L  AA+ GH  ++  L+
Sbjct: 684 LAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717



 Score =  105 bits (261), Expect = 3e-22
 Identities = 120/418 (28%), Positives = 172/418 (41%), Gaps = 36/418 (8%)

Query: 605  AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS-G 663
            AE+  N    D++   +L  A   G    V  L   G S  + E   +   L   A S G
Sbjct: 224  AESTANAGQSDNR---SLAEACSEGDVNAVRKLLIEGRS--VNEHTEEGESLLCLACSAG 278

Query: 664  HTDSLHLLI-------DSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADA 716
            + +   +L+       D G + DIT         PLM A   GHV  V LLL   +  +A
Sbjct: 279  YYELAQVLLAMHANVEDRGIKGDIT---------PLMAAANGGHVKIVKLLLAHKADVNA 329

Query: 717  ADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQA 776
                G TAL      G  D +  LL+  A +   +  G TP+  A + GH  V R LL+ 
Sbjct: 330  QSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLEN 389

Query: 777  ALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCAVINNQ 835
                  ++   +    S +  A Y GH + +  LLE  +   +      T L  A ++  
Sbjct: 390  GAG---INTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH 446

Query: 836  DSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL 895
                 +LL + GA+ VN       +PL  AA   +V    +L++  A +   +  G T L
Sbjct: 447  VEVARLLLDS-GAQ-VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPL 504

Query: 896  MTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLIN 955
            M AA  G    V  LL +G       +E + TAL LAC  G  + A  ++    D+ L  
Sbjct: 505  MEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC 564

Query: 956  ATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPN--KDVADCL 1011
            +T      PL  AA+ G   +V+ LL+ GA V A    G T       N   DVAD L
Sbjct: 565  ST------PLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVL 616



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 87/273 (31%), Positives = 134/273 (49%), Gaps = 15/273 (5%)

Query: 7    TDQPPLVQAIFSRDVEEVRSLLSQ---KENINVLDQERRTPLHAAAYVGDVPILQLLLMS 63
            T   PL  A      E V  LL++   KE+ NV D    TPL  AA  G V I+++LL +
Sbjct: 898  TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY---TPLSLAASGGYVNIIKILLNA 954

Query: 64   GANVNAK--DTLWLTPLHRAAASRNEKVLGLLLAHSADVNAR-DKLWQTPLHVAAANRAT 120
            GA +N++    L ++PL  AA + +   + LLL   +D+NA+ +    T L +A     T
Sbjct: 955  GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1014

Query: 121  KCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV--CDKKERQPLH 178
            +    L    +++    ++G + L  A   G+ E   +LL+KGA +N           L 
Sbjct: 1015 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1074

Query: 179  WAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAF 238
             AA  GH +  +LL+ RGA +  +++KG   L  AA  G ++VV+ L++ GA++D  +  
Sbjct: 1075 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1134

Query: 239  GNTALHIACYLGQDAVAIELVNAGANVNQ-PND 270
              T L  A   G   V   LV     VNQ P+D
Sbjct: 1135 KITPLMAAFRKGHVKVVRYLVK---EVNQFPSD 1164



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 74/228 (32%), Positives = 113/228 (49%), Gaps = 5/228 (2%)

Query: 5    SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERR--TPLHAAAYVGDVPILQLLLM 62
            +++D  PL  A     V  ++ LL+    IN     +   +PL  AA  G    ++LLL 
Sbjct: 929  NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD 988

Query: 63   SGANVNAK-DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATK 121
             G+++NA+ +T   T L  A      +V+ LLL   A+V  R K   TPL  AA+    +
Sbjct: 989  MGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1048

Query: 122  CAEALAPLLSSLNV--ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHW 179
                L    + +N      S  +AL  A   GH +   LL+ +GA ++V +KK   PL  
Sbjct: 1049 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWL 1108

Query: 180  AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227
            AA  GHL+V++LLV  GAD+   D +    L  A   G ++VV+YL++
Sbjct: 1109 AANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 58/177 (32%), Positives = 83/177 (46%), Gaps = 4/177 (2%)

Query: 851  VNSRDAKGR-TPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 909
            V  R  KG  TPL AAA   +V  +++LL H+A+VNA   TG TAL  A   G    V+ 
Sbjct: 293  VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKV 352

Query: 910  LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969
            LL  G A +   +EN +T L  A S GH + A ++L      G+   +N   +  L +A 
Sbjct: 353  LLESG-ASIEDHNENGHTPLMEAGSAGHVEVARLLLEN--GAGINTHSNEFKESALTLAC 409

Query: 970  RNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFPPKDA 1026
              G   +V+ LL  GA      +E HT  +    +  V     L+ S  +   P D+
Sbjct: 410  YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  234 bits (598), Expect = 3e-61
 Identities = 189/655 (28%), Positives = 301/655 (45%), Gaps = 56/655 (8%)

Query: 22   EEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRA 81
            +EV  LL  K   +V  ++ RT       +     ++ LL +GA+VN  D+   T L  A
Sbjct: 494  QEVLQLLV-KAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANA 552

Query: 82   AASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGR 141
            A S +  V+ LL++  AD+   D    TPL +AA    TK    L    +++N  D+ G 
Sbjct: 553  AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612

Query: 142  SALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGC 201
            +AL  A   GH E V+ LL  G  ++  D   R  L  AA+ GH +++  L+  GA++  
Sbjct: 613  TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672

Query: 202  KDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYL-----GQDAVAI 256
             D +G   L  AA  G  E+V++LL  GAE++  +  G TAL +A        G  +V  
Sbjct: 673  ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732

Query: 257  ELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIH 316
             L++ GA V+  +  G TPL VAA   +  + ++LL+  GADV++    G++PL  AA  
Sbjct: 733  LLIDRGAEVDHCDKDGMTPLLVAAYEGHVDV-VDLLLEGGADVDHTDNNGRTPLLAAASM 791

Query: 317  GRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPL 376
            G  +    L+  G+ +D  D  G T L +A+  G+  ++ TL+  G D   R      PL
Sbjct: 792  GHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPL 851

Query: 377  HLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNV 436
            H+A   G    C  L+  G                     N  DN GR     A+  G+ 
Sbjct: 852  HMAAFEGHRLICEALIEQGA------------------RTNEIDNDGRIPFILASQEGHY 893

Query: 437  ECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYA 496
            +C+ +LL + +++ +R   GR  L  AA  G       L + GA VN  D  G   L+  
Sbjct: 894  DCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYIL 953

Query: 497  AASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHY 556
            A  +    A                            E+ L+NGA+    D +G TA+H 
Sbjct: 954  ALENQLTMA----------------------------EYFLENGANVEASDAEGRTALHV 985

Query: 557  AAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDH 616
            +   G+ + +++L+  +++   +       S L  AA+ GH + ++ L E    +D   +
Sbjct: 986  SCWQGHMEMVQVLI--AYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCN 1043

Query: 617  KGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLL 671
            +G TAL +A + G  + V+VL  HGA     ++  + T +  AA +GH+  + LL
Sbjct: 1044 QGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGR-TAMRVAAKNGHSQIIKLL 1097



 Score =  231 bits (589), Expect = 3e-60
 Identities = 209/747 (27%), Positives = 324/747 (43%), Gaps = 91/747 (12%)

Query: 258  LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHG 317
            LV AGA+VN  +D+    +  A    +    +  L++NGA VN     G++ L  AA  G
Sbjct: 500  LVKAGAHVNSEDDRTSCIVRQALEREDS---IRTLLDNGASVNQCDSNGRTLLANAAYSG 556

Query: 318  RFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLH 377
                  +L+  G++++  D  G+TPL +AAR GH  +++ L+  GA+           L 
Sbjct: 557  SLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALR 616

Query: 378  LAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVE 437
             A   G ++             +VS+L     L AG  ++  D   RT L AAA GG+ +
Sbjct: 617  SAAWGGHTE-------------VVSAL-----LYAGVKVDCADADSRTALRAAAWGGHED 658

Query: 438  CLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAA 497
             +  LL  GA++ + D  GRT L  AA  G  +    L+  GA VN  D  G + L  AA
Sbjct: 659  IVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAA 718

Query: 498  ASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYA 557
                        P+S              K     +  L+D GA+    D+ G T +  A
Sbjct: 719  LC---------VPAS--------------KGHASVVSLLIDRGAEVDHCDKDGMTPLLVA 755

Query: 558  AAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHK 617
            A  G+   ++LLLE   +   D       +PL  AA  GH   + TL      +D  D +
Sbjct: 756  AYEGHVDVVDLLLEGGADV--DHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSE 813

Query: 618  GRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGER 677
            GRT L +A+ +G+ E V  L   G     ++    WTPLH AA  GH      LI+ G R
Sbjct: 814  GRTVLSIASAQGNVEVVRTLLDRGLDENHRD-DAGWTPLHMAAFEGHRLICEALIEQGAR 872

Query: 678  ADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCL 737
               T+ +D  G+ P +LA   GH DCV +LLE  S  D     GR AL   A+ G  D +
Sbjct: 873  ---TNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIV 929

Query: 738  AALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHW 797
              L  H A V C+D  GR  +++ +      +    L+   + +  DA     G + +H 
Sbjct: 930  ELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDA----EGRTALHV 985

Query: 798  ASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAK 857
            + + GH + +++L+ +                                     VN+ D +
Sbjct: 986  SCWQGHMEMVQVLIAYHAD----------------------------------VNAADNE 1011

Query: 858  GRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKAD 917
             R+ L +AA+  +V  +++L++H A V+ T + G TAL  AA+ G    V+ LL  G AD
Sbjct: 1012 KRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG-AD 1070

Query: 918  LTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVV 977
                D+   TA+ +A   GH +  ++ L E      +N  + +    +       L+S V
Sbjct: 1071 PNHADQFGRTAMRVAAKNGHSQ--IIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKV 1128

Query: 978  QALLSHGATVLAVDEEGHTPALACAPN 1004
            Q+L     +  +       P+L   PN
Sbjct: 1129 QSLTIKSNSSGSTGGGDMQPSLRGLPN 1155



 Score =  225 bits (574), Expect = 2e-58
 Identities = 200/676 (29%), Positives = 312/676 (46%), Gaps = 57/676 (8%)

Query: 154  ETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTA 213
            E + LL+  GA +N  D +    +  A  L   + ++ L+  GA +   D  G  LL  A
Sbjct: 495  EVLQLLVKAGAHVNSEDDRTSCIVRQA--LEREDSIRTLLDNGASVNQCDSNGRTLLANA 552

Query: 214  AASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGF 273
            A SG ++VV  L+  GA+++  +A G+T L +A   G   V   L+  GAN+N  +  G+
Sbjct: 553  AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612

Query: 274  TPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEID 333
            T L  AA   +  +   LL   G  V+    + ++ L  AA  G       L+Q+G+E++
Sbjct: 613  TALRSAAWGGHTEVVSALLYA-GVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671

Query: 334  CADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLS 393
             AD  G T L  AA  GH  ++  L+ +GA+     +     L +A L         + +
Sbjct: 672  KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALC--------VPA 723

Query: 394  SGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRD 453
            S    S+VS L     +  G +++  D  G T L  AA  G+V+ ++LLL  GAD+   D
Sbjct: 724  SKGHASVVSLL-----IDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTD 778

Query: 454  KFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSH 513
              GRTPL  AA+ G      TL+  GA V+  D +G + L  A+A               
Sbjct: 779  NNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVE---------- 828

Query: 514  DAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMS 573
                               +  LLD G D + RD  G+T +H AA  G+R   E L+E  
Sbjct: 829  ------------------VVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870

Query: 574  FNCLE-DVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTE 632
                E D +  IP     LA+  GH + ++ L E   N+D R + GR AL +A   G  +
Sbjct: 871  ARTNEIDNDGRIPFI---LASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRD 927

Query: 633  CVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPL 692
             VE+L +HGA    K+   + T L+  A           +++G   + +D   A G+T L
Sbjct: 928  IVELLFSHGADVNCKDADGRPT-LYILALENQLTMAEYFLENGANVEASD---AEGRTAL 983

Query: 693  MLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDF 752
             ++   GH++ V +L+   +  +AAD   R+AL   A  G    +  L++H A V     
Sbjct: 984  HVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCN 1043

Query: 753  KGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE 812
            +G T + +A+  GH  V++ LL+     DP  A  D  G + M  A+  GH   ++LL +
Sbjct: 1044 QGATALCIAAQEGHIDVVQVLLEH--GADPNHA--DQFGRTAMRVAAKNGHSQIIKLLEK 1099

Query: 813  HSPFSYLEGNPFTPLH 828
            +   S L G   +P+H
Sbjct: 1100 YGA-SSLNGCSPSPVH 1114



 Score =  220 bits (560), Expect = 6e-57
 Identities = 180/585 (30%), Positives = 267/585 (45%), Gaps = 56/585 (9%)

Query: 11   PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
            PL  A      + V  L+    NIN  DQ+  T L +AA+ G   ++  LL +G  V+  
Sbjct: 581  PLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCA 640

Query: 71   DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
            D    T L  AA   +E ++  LL H A+VN  D   +T L  AA     +  E L    
Sbjct: 641  DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700

Query: 131  SSLNVADRSGRSALHHA-----VHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGH 185
            + +N  D  GR+AL  A        GH   V+LL+++GA ++ CDK    PL  AA+ GH
Sbjct: 701  AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGH 760

Query: 186  LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245
            ++V+ LL+  GAD+   D  G   L  AA+ G   VV  LL  GA +D  ++ G T L I
Sbjct: 761  VDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820

Query: 246  ACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKE 305
            A   G   V   L++ G + N  +D G+TPLH+AA   +  +C E L+  GA  N    +
Sbjct: 821  ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLIC-EALIEQGARTNEIDND 879

Query: 306  GKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADT 365
            G+ P  +A+  G +   QIL++N S ID     G   L VAA  GH  ++  L ++GAD 
Sbjct: 880  GRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADV 939

Query: 366  ARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRT 425
              +       L++  L              QL         E+ L  G ++   D  GRT
Sbjct: 940  NCKDADGRPTLYILAL------------ENQL------TMAEYFLENGANVEASDAEGRT 981

Query: 426  CLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEA 485
             LH +   G++E + +L++  AD+   D   R+ L  AA  G  +    L+  GA V+  
Sbjct: 982  ALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHT 1041

Query: 486  DCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSL 545
              +G + L  AA        E H                        ++ LL++GADP+ 
Sbjct: 1042 CNQGATALCIAA-------QEGHID---------------------VVQVLLEHGADPNH 1073

Query: 546  RDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLH 590
             D+ G TA+  AA  G+ Q ++LL +   + L         SP+H
Sbjct: 1074 ADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSP----SPVH 1114



 Score =  205 bits (522), Expect = 2e-52
 Identities = 184/612 (30%), Positives = 274/612 (44%), Gaps = 51/612 (8%)

Query: 409  VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468
            ++ AG  +N+ D+  RT      +    + +  LL +GA + + D  GRT L  AA +GS
Sbjct: 500  LVKAGAHVNSEDD--RTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGS 557

Query: 469  YQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKE 528
                  LV+ GA +   D  G +PL  AA        + HT                   
Sbjct: 558  LDVVNLLVSRGADLEIEDAHGHTPLTLAAR-------QGHTK------------------ 592

Query: 529  AFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSP 588
                +  L+  GA+ +  D+ G+TA+  AA  G+ + +  LL        D       + 
Sbjct: 593  ---VVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKV--DCADADSRTA 647

Query: 589  LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
            L  AA+ GH + +  L +    ++  D++GRTAL  A   G  E VE L  HGA    ++
Sbjct: 648  LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHED 707

Query: 649  RKRKWTPLHAA----AASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCV 704
               +     AA    A+ GH   + LLID G   D  D     G TPL++A   GHVD V
Sbjct: 708  VDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCD---KDGMTPLLVAAYEGHVDVV 764

Query: 705  HLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASAC 764
             LLLE G+  D  D  GRT L   A  G    +  LL   A V   D +GRT + +ASA 
Sbjct: 765  DLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQ 824

Query: 765  GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPFSYLEGNP 823
            G+  V+RTLL   L  +  D     +G++P+H A++ GH    E L+E  +  + ++ + 
Sbjct: 825  GNVEVVRTLLDRGLDENHRDD----AGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880

Query: 824  FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAE 883
              P   A         ++LL       ++ R   GR  L  AA   +   + +L  H A+
Sbjct: 881  RIPFILASQEGHYDCVQILLE--NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGAD 938

Query: 884  VNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALM 943
            VN  D  GR  L   A   Q    E+ L  G A++   D    TALH++C +GH +   +
Sbjct: 939  VNCKDADGRPTLYILALENQLTMAEYFLENG-ANVEASDAEGRTALHVSCWQGHMEMVQV 997

Query: 944  ILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAP 1003
            ++A   D   +NA ++  +  L  AA  G   VVQ L+ HGA V     +G T AL  A 
Sbjct: 998  LIAYHAD---VNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGAT-ALCIAA 1053

Query: 1004 NKDVADCLALIL 1015
             +   D + ++L
Sbjct: 1054 QEGHIDVVQVLL 1065



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 53/175 (30%), Positives = 80/175 (45%), Gaps = 6/175 (3%)

Query: 9    QPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVN 68
            +P L        +      L    N+   D E RT LH + + G + ++Q+L+   A+VN
Sbjct: 947  RPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVN 1006

Query: 69   AKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128
            A D    + L  AA   + KV+ LL+ H A V+       T L +AA        + L  
Sbjct: 1007 AADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLE 1066

Query: 129  LLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGA-SLNVCDKK-----ERQPL 177
              +  N AD+ GR+A+  A  +GH + + LL   GA SLN C        E++PL
Sbjct: 1067 HGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPL 1121


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  230 bits (587), Expect = 5e-60
 Identities = 251/871 (28%), Positives = 353/871 (40%), Gaps = 160/871 (18%)

Query: 12  LVQAIFSRDVEEVRSLLSQKENINVLDQERR--TPLHAAAYVGDVPILQLLLMSGANVNA 69
           L++A  + DV  V+ L+    N+N  D   R  +PLH AA  G   +++ LL  GANV+A
Sbjct: 186 LLEACRNGDVSRVKRLVDAA-NVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244

Query: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAA-------------- 115
           +D   L PLH A +  + +V+ LLL   AD NARD    TPLH AA              
Sbjct: 245 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304

Query: 116 -----------------ANRATKCA-------------------EALAPLLSSLNV---- 135
                            A+ + K                     E L  LL+ LNV    
Sbjct: 305 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA 364

Query: 136 ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVAR 195
           +D    + LH A     +  V LLL  GA ++  DK    PLH A   GH EV +LL+  
Sbjct: 365 SDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKH 424

Query: 196 GADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTAL------------ 243
           GA +   D   +  LH AA+  ++EV   LL  GA+    N  G +A+            
Sbjct: 425 GACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERL 484

Query: 244 ------HIACYLGQDA--------VAIELVNAGANVNQPNDKGFTPLH--VAAVSTNGAL 287
                 H      ++A        +A+E++    N  QP     T LH  VA++      
Sbjct: 485 TYEFKGHSLLQAAREADLAKVKKTLALEII----NFKQPQSHE-TALHCAVASLHPKRKQ 539

Query: 288 CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAA 347
             ELL+  GA+VN ++K+  +PLH+AA        ++L ++G++++  D  G T LH AA
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599

Query: 348 RYGHELLISTLMTNGADTARRGIHDMFPLHL-----------AVLFGFSDCCRKLLSSGQ 396
             GH      L++ G+D +   +       +           +     SD   +LL +  
Sbjct: 600 LAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEA-- 657

Query: 397 LYSIVSSLSNEHVLSAGFDINTPDNLGR--TCLHAAASGGNVECLNLLLSSGADLRRRDK 454
             S    L     L +  ++N  D  GR  T LH AA    V  +  LL  GAD+  +DK
Sbjct: 658 --SKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDK 715

Query: 455 FGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHD 514
            G  PLH A + G Y+ A  LV  GA VN AD    +PLH AAA   Y            
Sbjct: 716 GGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYE----------- 764

Query: 515 AEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSF 574
                              + LL +GADP+ ++R G T             L+L+ E   
Sbjct: 765 -----------------ICKLLLKHGADPTKKNRDGNTP------------LDLVKEGD- 794

Query: 575 NCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGR--TALFLATERGSTE 632
               D++  +      L A    C A      T  N++ RD +GR  T L LA    + E
Sbjct: 795 ---TDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLE 851

Query: 633 CVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPL 692
             E L  HGA    ++ K    PLH AA+ GH D   LLI      + T   D +  TPL
Sbjct: 852 VAEYLLEHGADVNAQD-KGGLIPLHNAASYGHVDIAALLIKYNTCVNAT---DKWAFTPL 907

Query: 693 MLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDF 752
             A   G      LLL  G+     +  G+T L           L   +  +A   C  F
Sbjct: 908 HEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTC--F 965

Query: 753 KGRTPIHLASACGHTAVLRTLLQAALSTDPL 783
           K +  +  AS     A   + L AA S D L
Sbjct: 966 KPQATVVSASLIS-PASTPSCLSAASSIDNL 995



 Score =  218 bits (556), Expect = 2e-56
 Identities = 235/805 (29%), Positives = 352/805 (43%), Gaps = 119/805 (14%)

Query: 131 SSLNVADRSGR--SALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEV 188
           +++N  D +GR  S LH A   G  + V  LL  GA+++  D     PLH A   GH EV
Sbjct: 205 ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEV 264

Query: 189 LKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA-- 246
           + LL+ +GAD   +D   Y  LH AA  G+I+V   LL+ GA+ +  N  G +AL +A  
Sbjct: 265 VSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADP 324

Query: 247 ---CYLGQDAVAIELVNA----------------GANVNQPNDKGFTPLHVAAVSTNGAL 287
                L  +    EL+ A                  N +  + +  TPLH+AA   N   
Sbjct: 325 SAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAA-GYNRVR 383

Query: 288 CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAA 347
            ++LL+ +GADV+ + K G  PLH A  +G +  +++L+++G+ ++  D +  TPLH AA
Sbjct: 384 IVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAA 443

Query: 348 RYGHELLISTLMTNGADTARRGIH-----DMFP---LHLAVLFGFSDCCRKLLSSGQ--- 396
                 + S L+++GAD      H     DM P   L   + + F      LL + +   
Sbjct: 444 SKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKG--HSLLQAAREAD 501

Query: 397 LYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASG---GNVECLNLLLSSGADLRRRD 453
           L  +  +L+ E +     +   P +   T LH A +       +   LLL  GA++  ++
Sbjct: 502 LAKVKKTLALEII-----NFKQPQS-HETALHCAVASLHPKRKQVTELLLRKGANVNEKN 555

Query: 454 KFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSH 513
           K   TPLH AA          L   GA +N  D  G + LH AA +   +          
Sbjct: 556 KDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTC-------- 607

Query: 514 DAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMS 573
                                 LL  G+DPS+   QG+T    AA  GN    ++L E +
Sbjct: 608 --------------------RLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSEST 643

Query: 574 FNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGR--TALFLATERGST 631
                DV+       L  A+  G  E +K L  +  N++ RD +GR  T L  A      
Sbjct: 644 PIRTSDVDYR-----LLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRV 697

Query: 632 ECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTP 691
             VE L  HGA    K+ K    PLH A + GH +   LL+  G   ++ D+   +  TP
Sbjct: 698 SVVEYLLHHGADVHAKD-KGGLVPLHNACSYGHYEVAELLVRHGASVNVADL---WKFTP 753

Query: 692 LMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALH--RGAVTGCEDCL---AALLD---- 742
           L  A   G  +   LLL+ G+     +  G T L   +   T  +D L   AALLD    
Sbjct: 754 LHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKK 813

Query: 743 ----------HDAFVLCRDFKGR--TPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYS 790
                         + CRD +GR  TP+HLA+   +  V   LL+     +  D G    
Sbjct: 814 GCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG---- 869

Query: 791 GYSPMHWASYTGHEDCLELLLEHSP-FSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAK 849
           G  P+H A+  GH D   LL++++   +  +   FTPLH A    +     +LL A GA 
Sbjct: 870 GLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLL-AHGAD 928

Query: 850 IVNSRDAKGRTPLHAAAFADNVSGL 874
               ++ +G+TPL  A  AD++  L
Sbjct: 929 -PTMKNQEGQTPLDLAT-ADDIRAL 951



 Score =  196 bits (498), Expect = 1e-49
 Identities = 253/903 (28%), Positives = 357/903 (39%), Gaps = 150/903 (16%)

Query: 246  ACYLGQDAVAIELVNAGANVNQPNDKG--FTPLHVAAVSTNGALCLELLVNNGADVNYQS 303
            AC  G  +    LV+A ANVN  +  G   +PLH AA      + +E L+  GA+V+ + 
Sbjct: 189  ACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDV-VEHLLQMGANVHARD 246

Query: 304  KEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGA 363
              G  PLH A   G      +L+  G++ +  D +  TPLH AA  G   +   L+ +GA
Sbjct: 247  DGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGA 306

Query: 364  DTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQ-----LYSIVSSLSNEHVLSAGFDINT 418
            D   R       L LA      D   K + +G+     L     S + E +++    +N 
Sbjct: 307  DPNIRNTDGKSALDLA------DPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNV 360

Query: 419  ----PDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVT 474
                 D    T LH AA    V  + LLL  GAD+  +DK G  PLH A + G Y+    
Sbjct: 361  NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420

Query: 475  LVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLE 534
            L+  GA VN  D    +PLH AA+ +   R E                            
Sbjct: 421  LLKHGACVNAMDLWQFTPLHEAASKN---RVE-------------------------VCS 452

Query: 535  FLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAY 594
             LL +GADP+L +  G +AV  A     R+ L    +               S L  A  
Sbjct: 453  LLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGH-------------SLLQAARE 499

Query: 595  NGHCEALKTLAETLVNLDVRDHKGRTALFLATER---GSTECVEVLTAHGASALIKERKR 651
                +  KTLA  ++N   +     TAL  A         +  E+L   GA+  + E+ +
Sbjct: 500  ADLAKVKKTLALEIINFK-QPQSHETALHCAVASLHPKRKQVTELLLRKGAN--VNEKNK 556

Query: 652  KW-TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710
             + TPLH AA   H D + +L   G + +    +D  GQT L  A + GH+    LLL  
Sbjct: 557  DFMTPLHVAAERAHNDVMEVLHKHGAKMN---ALDTLGQTALHRAALAGHLQTCRLLLSY 613

Query: 711  GSTADAADLRGRTALHRG--------------------------AVTGCEDCLAALLDHD 744
            GS      L+G TA   G                          +  G  + +  L    
Sbjct: 614  GSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ 673

Query: 745  AFVLCRDFKGR--TPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTG 802
              V CRD +GR  TP+H A+     +V+  LL         D G    G  P+H A   G
Sbjct: 674  N-VNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKG----GLVPLHNACSYG 728

Query: 803  HEDCLELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTP 861
            H +  ELL+ H +  +  +   FTPLH A    +    ++LL         +RD  G TP
Sbjct: 729  HYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRD--GNTP 786

Query: 862  LHAAAFADNVSGLRMLLQHQA---------------------EVNATDHTGR--TALMTA 898
            L      D  + ++ LL+  A                      +N  D  GR  T L  A
Sbjct: 787  LDLVKEGD--TDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLA 844

Query: 899  AENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATN 958
            A        E+LL  G AD+   D+     LH A S GH   A +++        +NAT+
Sbjct: 845  AGYNNLEVAEYLLEHG-ADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNT---CVNATD 900

Query: 959  SALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPA-LACAPNKDVADCLALILST 1017
                 PLH AA+ G   +   LL+HGA     ++EG TP  LA A      D  AL++  
Sbjct: 901  KWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD-----DIRALLIDA 955

Query: 1018 MKP------FPPKDAV---SPFSFSLLKNCSIAAAKTVGGCGALPHGASCPYSQERPGAI 1068
            M P      F P+  V   S  S +   +C  AA+      G L   A    S    GA 
Sbjct: 956  MPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAA 1015

Query: 1069 GLD 1071
            G +
Sbjct: 1016 GTE 1018



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 33/120 (27%), Positives = 51/120 (42%), Gaps = 3/120 (2%)

Query: 895  LMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLI 954
            L+ A  NG  + V+ L+     +   +   K++ LH A   G +     +L   Q    +
Sbjct: 186  LLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLL---QMGANV 242

Query: 955  NATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALI 1014
            +A +    +PLH A   G A VV  LL  GA   A D   +TP    A    +  C+ L+
Sbjct: 243  HARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 302


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  226 bits (577), Expect = 7e-59
 Identities = 222/769 (28%), Positives = 329/769 (42%), Gaps = 128/769 (16%)

Query: 12  LVQAIFSRDVEEVRSLLSQKENINVLDQERR--TPLHAAAYVGDVPILQLLLMSGANVNA 69
           L +A  + DVE V+ L++  E +N  D   R  TPLH AA  G   +++ LL +GANV A
Sbjct: 28  LFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86

Query: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAA-------------- 115
           +D   L PLH A +  + +V+ LLL H AD NARD    TPLH AA              
Sbjct: 87  RDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 146

Query: 116 -----------------ANRATKCA-------------------EALAPLLSSLNV---- 135
                            A+ + K                     E +  LL+ LNV    
Sbjct: 147 GAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHA 206

Query: 136 ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVAR 195
           +D    + LH A     ++ V LLL  GA ++  DK +  PLH A   GH EV +LLV  
Sbjct: 207 SDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKH 266

Query: 196 GADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACY------L 249
           GA +   D   +  LH AA+  ++EV   LL  GA+    N    +A+ +A        L
Sbjct: 267 GACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERL 326

Query: 250 GQDAVAIELVNAGANVNQPNDKGF---------------TPLHVAAVST---NGALCLEL 291
             +     L+ A    +    K                 T LH AA S       +C EL
Sbjct: 327 AYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQIC-EL 385

Query: 292 LVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGH 351
           L+  GA++N ++KE  +PLH+A+        ++++++ ++++  D  G T LH AA  GH
Sbjct: 386 LLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH 445

Query: 352 ELLISTLMTNGADTARRGIHDMFPLHLA-----------VLFGFSDCCRKLLSSGQLYSI 400
                 L++ G D     +     L +            +  G S+  R+LL + +    
Sbjct: 446 LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAK---- 501

Query: 401 VSSLSNEHVLSAGFDINTPDNLGR--TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRT 458
              +     L     +N  D  GR  T LH AA    V  +  LL  GAD+  +DK G  
Sbjct: 502 AGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLV 561

Query: 459 PLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTY---------------R 503
           PLH A + G Y+ A  LV  GA VN AD    +PLH AAA   Y               +
Sbjct: 562 PLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKK 621

Query: 504 RAEPHTPSSHDAEEDEPLKESRRKEAFF-------CLEFL--LDNGADPSLRDRQG--YT 552
             + +TP     + D  +++  R +A         CL  +  L +  + + RD QG   T
Sbjct: 622 NRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHST 681

Query: 553 AVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLD 612
            +H AA Y N +  E LL+   +   + +    + PLH AA  GH +    L +    ++
Sbjct: 682 PLHLAAGYNNLEVAEYLLQHGADV--NAQDKGGLIPLHNAASYGHVDVAALLIKYNACVN 739

Query: 613 VRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAA 661
             D    T L  A ++G T+   +L AHGA   +K ++ + TPL   +A
Sbjct: 740 ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQ-TPLDLVSA 787



 Score =  190 bits (483), Expect = 5e-48
 Identities = 245/891 (27%), Positives = 365/891 (40%), Gaps = 102/891 (11%)

Query: 230  AEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG--FTPLHVAAVSTNGAL 287
            AE  EP A     L  AC  G D   ++ +     VN  +  G   TPLH AA      +
Sbjct: 18   AEAVEPAA---RELFEACRNG-DVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDV 73

Query: 288  CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAA 347
             +E L+ NGA+V  +   G  PLH A   G      +L+++G++ +  D +  TPLH AA
Sbjct: 74   -VEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAA 132

Query: 348  RYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQ-----LYSIVS 402
              G   +   L+ +GA+   R       L LA      D   K + +G+     L     
Sbjct: 133  IKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA------DPSAKAVLTGEYKKDELLESAR 186

Query: 403  SLSNEHVLSAGFDINT----PDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRT 458
            S + E +++    +N      D    T LH AA    V+ + LLL  GAD+  +DK    
Sbjct: 187  SGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLV 246

Query: 459  PLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEED 518
            PLH A + G Y+    LV  GA VN  D    +PLH AA+ +           S+ A  D
Sbjct: 247  PLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCS--LLLSYGA--D 302

Query: 519  EPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQN--LELLLEMSFNC 576
              L     K A       +D    P L++R  Y    ++     R+     +   +S   
Sbjct: 303  PTLLNCHNKSA-------IDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM 355

Query: 577  LEDVESTIPVSPLHLAAYNGHCEALKTLAETLV----NLDVRDHKGRTALFLATERGSTE 632
            +         + LH AA + + +  K + E L+    N++ +  +  T L +A+E+   +
Sbjct: 356  VNFKHPQTHETALHCAAASPYPKR-KQICELLLRKGANINEKTKEFLTPLHVASEKAHND 414

Query: 633  CVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPL 692
             VEV+  H A     +   + T LH AA  GH  +  LL+  G   +I  +    G T L
Sbjct: 415  VVEVVVKHEAKVNALDNLGQ-TSLHRAAYCGHLQTCRLLLSYGCDPNIISLQ---GFTAL 470

Query: 693  MLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDF 752
             +   N     V  LL++G +   ++   +  L   A  G  + +  L    + V CRD 
Sbjct: 471  QMGNEN-----VQQLLQEGISLGNSEADRQ--LLEAAKAGDVETVKKLCTVQS-VNCRDI 522

Query: 753  KGR--TPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL 810
            +GR  TP+H A+     +V+  LLQ        D G    G  P+H A   GH +  ELL
Sbjct: 523  EGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKG----GLVPLHNACSYGHYEVAELL 578

Query: 811  LEHSPF-SYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFAD 869
            ++H    +  +   FTPLH A    +    ++LL         +RD  G TPL      D
Sbjct: 579  VKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRD--GNTPLDLVKDGD 636

Query: 870  NVSGLRMLLQHQA---------------------EVNATDHTGR--TALMTAAENGQTAA 906
              + ++ LL+  A                      VN  D  GR  T L  AA       
Sbjct: 637  --TDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEV 694

Query: 907  VEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLH 966
             E+LL  G AD+   D+     LH A S GH   A +++        +NAT+     PLH
Sbjct: 695  AEYLLQHG-ADVNAQDKGGLIPLHNAASYGHVDVAALLIKYN---ACVNATDKWAFTPLH 750

Query: 967  IAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFPPKDA 1026
             AA+ G   +   LL+HGA     ++EG TP    + +    D  AL+ + M   PP   
Sbjct: 751  EAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD----DVSALLTAAM---PPSAL 803

Query: 1027 VSPFSFSLLKNCSIAAAKTVGGCGALPHGASCPYSQERPGAI-GLDGCYSE 1076
             S +   +L       A       AL  G S P S     ++  L G +SE
Sbjct: 804  PSCYKPQVLNGVRSPGAT----ADALSSGPSSPSSLSAASSLDNLSGSFSE 850



 Score =  180 bits (456), Expect = 7e-45
 Identities = 181/611 (29%), Positives = 265/611 (43%), Gaps = 124/611 (20%)

Query: 12  LVQAIFSRDVEEVRSLLSQKE-NINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           L+++  S + E++ +LL+    N +  D  + TPLH AA    V I+QLLL  GA+V+AK
Sbjct: 181 LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK 240

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQ-TPLHVAAA-NRATKC------ 122
           D   L PLH A +  + +V  LL+ H A VNA D LWQ TPLH AA+ NR   C      
Sbjct: 241 DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMD-LWQFTPLHEAASKNRVEVCSLLLSY 299

Query: 123 -------------AEALAP----------------LLSSLNVAD---------------- 137
                        A  LAP                LL +   AD                
Sbjct: 300 GADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFK 359

Query: 138 --RSGRSALHHAVHSGH---LETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLL 192
             ++  +ALH A  S +    +   LLL KGA++N   K+   PLH A+   H +V++++
Sbjct: 360 HPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVV 419

Query: 193 VARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA------ 246
           V   A +   D  G   LH AA  G ++  + LL  G + +  +  G TAL +       
Sbjct: 420 VKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQ 479

Query: 247 -----CYLGQ---DAVAIELVNAG-------------ANVNQPNDKGFTPLHVAAVSTNG 285
                  LG    D   +E   AG              N      +  TPLH AA   N 
Sbjct: 480 LLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAA-GYNR 538

Query: 286 ALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHV 345
              +E L+ +GADV+ + K G  PLH A  +G +  +++L+++G+ ++ AD +  TPLH 
Sbjct: 539 VSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHE 598

Query: 346 AARYGHELLISTLMTNGADTARRGIHDMFPLHL----------------AVLFGFSDCC- 388
           AA  G   +   L+ +GAD  ++      PL L                A+L      C 
Sbjct: 599 AAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCL 658

Query: 389 ---RKLLSSGQL------------YSIVSSLSN----EHVLSAGFDINTPDNLGRTCLHA 429
              +KL S   +              + +  +N    E++L  G D+N  D  G   LH 
Sbjct: 659 ARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHN 718

Query: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 489
           AAS G+V+   LL+   A +   DK+  TPLH AA  G  Q    L+  GA     + +G
Sbjct: 719 AASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEG 778

Query: 490 CSPLHYAAASD 500
            +PL   +A D
Sbjct: 779 QTPLDLVSADD 789



 Score =  157 bits (397), Expect = 5e-38
 Identities = 155/565 (27%), Positives = 232/565 (41%), Gaps = 126/565 (22%)

Query: 8   DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGA-- 65
           D  PL  A      E    L+     +N +D  + TPLH AA    V +  LLL  GA  
Sbjct: 244 DLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADP 303

Query: 66  ---NVNAKDTLWLTP--------------------------------------------- 77
              N + K  + L P                                             
Sbjct: 304 TLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQT 363

Query: 78  ----LHRAAAS---RNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
               LH AAAS   + +++  LLL   A++N + K + TPLHVA+        E +    
Sbjct: 364 HETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHE 423

Query: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVC-----------DKKERQPLHW 179
           + +N  D  G+++LH A + GHL+T  LLL+ G   N+            ++  +Q L  
Sbjct: 424 AKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQE 483

Query: 180 AAFLGHLEVLKLLV--ARGAD------------LGCKDRKGYGL--LHTAAASGQIEVVK 223
              LG+ E  + L+  A+  D            + C+D +G     LH AA   ++ VV+
Sbjct: 484 GISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVE 543

Query: 224 YLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVST 283
           YLL+ GA++   +  G   LH AC  G   VA  LV  GA VN  +   FTPLH AA   
Sbjct: 544 YLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKG 603

Query: 284 NGALCLELLVNNGADVNYQSKEGKSPLHM--------------------AAIHGRFTRSQ 323
              +C +LL+ +GAD   ++++G +PL +                    AA  G   R +
Sbjct: 604 KYEIC-KLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVK 662

Query: 324 ILIQNGSEIDCADKFG--NTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVL 381
            L  +   ++C D  G  +TPLH+AA Y +  +   L+ +GAD   +    + PLH A  
Sbjct: 663 KL-SSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAAS 721

Query: 382 FGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNL 441
           +G  D    L+                       +N  D    T LH AA  G  +   L
Sbjct: 722 YGHVDVAALLIKYNAC------------------VNATDKWAFTPLHEAAQKGRTQLCAL 763

Query: 442 LLSSGADLRRRDKFGRTPLHYAAAN 466
           LL+ GAD   +++ G+TPL   +A+
Sbjct: 764 LLAHGADPTLKNQEGQTPLDLVSAD 788



 Score =  120 bits (301), Expect = 7e-27
 Identities = 94/300 (31%), Positives = 143/300 (47%), Gaps = 26/300 (8%)

Query: 12  LVQAIFSRDVEEVRSLLS-QKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           L++A  + DVE V+ L + Q  N   ++  + TPLH AA    V +++ LL  GA+V+AK
Sbjct: 496 LLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAK 555

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQ-TPLHVAAANRATKCAEALAPL 129
           D   L PLH A +  + +V  LL+ H A VN  D LW+ TPLH AAA    +  + L   
Sbjct: 556 DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVAD-LWKFTPLHEAAAKGKYEICKLLLQH 614

Query: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDK------------------ 171
            +     +R G + L   V  G  +  +LL    A L+   K                  
Sbjct: 615 GADPTKKNRDGNTPLD-LVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCR 673

Query: 172 ----KERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227
               +   PLH AA   +LEV + L+  GAD+  +D+ G   LH AA+ G ++V   L++
Sbjct: 674 DTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIK 733

Query: 228 MGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGAL 287
             A ++  + +  T LH A   G+  +   L+  GA+    N +G TPL + +     AL
Sbjct: 734 YNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSAL 793



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 42/118 (35%), Positives = 58/118 (49%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           PL  A    ++E    LL    ++N  D+    PLH AA  G V +  LL+   A VNA 
Sbjct: 682 PLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNAT 741

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128
           D    TPLH AA     ++  LLLAH AD   +++  QTPL + +A+  +    A  P
Sbjct: 742 DKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMP 799



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 27/88 (30%), Positives = 37/88 (42%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           PL  A     V+    L+     +N  D+   TPLH AA  G   +  LLL  GA+   K
Sbjct: 715 PLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLK 774

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSA 98
           +    TPL   +A     +L   +  SA
Sbjct: 775 NQEGQTPLDLVSADDVSALLTAAMPPSA 802


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score =  201 bits (512), Expect = 2e-51
 Identities = 169/584 (28%), Positives = 259/584 (44%), Gaps = 62/584 (10%)

Query: 427 LHAAASGGNVECLNLLLSSGADLR-RRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEA 485
           +HAAA  G+   L  L+   + L+ + D+FGRTPL Y        CA  L+ AGA VN+ 
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 486 DCKGCSPLHYAAASDTYR-----RAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNG 540
           D    + LH AA    YR               D EE  PL  + R  +  CL  LL   
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 541 A--DPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNC-LEDVESTIPVSPLHLAAYNGH 597
           A  +   +D+   TA+H++A Y N ++++LL++   N  + DVE  IP   LH AA +  
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIP---LHWAANHKD 194

Query: 598 CEALKTL------AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651
             A+ T+      A T   L+ +D++GRT L  A   G+   V+VLT++ +  +      
Sbjct: 195 PSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254

Query: 652 KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711
             TPLH AA  GH   +HLL++  +   I    D+ G TPL  A  +   + V + L+  
Sbjct: 255 FRTPLHWAALLGHAQIVHLLLERNKSGTIPS--DSQGATPLHYAAQSNFAETVKVFLKHP 312

Query: 712 STADAADLRGRTALHRGAVTGCEDCLAALLD--HDAFVLCRDFKGRTPIHLASACGHTAV 769
           S  D +DL GRT+    A  G +D L  +L    D  +   D  G T +H A+  GH + 
Sbjct: 313 SVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVST 372

Query: 770 LRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHC 829
           ++ LL+     D      D   ++P+  A   GH+D ++ L++                 
Sbjct: 373 VKLLLENNAQVD----ATDVMKHTPLFRACEMGHKDVIQTLIK----------------- 411

Query: 830 AVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDH 889
                            G   V+  D  G + LH AA   N    ++L++++   N  D+
Sbjct: 412 -----------------GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDY 454

Query: 890 TGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQ 949
            GRT L  AA  G    +  L+    AD  + D+   TALH +C+ G+   A+ +L +  
Sbjct: 455 AGRTPLQCAAYGGYINCMAVLM-ENNADPNIQDKEGRTALHWSCNNGYLD-AIKLLLDFA 512

Query: 950 DLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEE 993
                   N     PL  A       V+Q +L HGA  +A  ++
Sbjct: 513 AFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQD 556



 Score =  171 bits (434), Expect = 3e-42
 Identities = 150/508 (29%), Positives = 229/508 (45%), Gaps = 39/508 (7%)

Query: 26  SLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASR 85
           S L  KE     DQ  RTPL        +     LL +GA+VN  D    T LH AA   
Sbjct: 38  SALKDKE-----DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKG 92

Query: 86  NEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLS--SLNVADRSGRSA 143
           N + + LLL   A+   +D    TPLH+   +R+ KC   L   ++   ++  D++ ++A
Sbjct: 93  NYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTA 152

Query: 144 LHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLE------VLKLLVARGA 197
           LH + +  + E V LL+   +++ + D + + PLHWAA   H +      V  +L A   
Sbjct: 153 LHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAA--NHKDPSAVHTVRCILDAAPT 210

Query: 198 D--LGCKDRKGYGLLHTAAASGQIEVVKYLLRM-GAEIDEPNAFGNTALHIACYLGQDAV 254
           +  L  +D +G   LH A A G + VV  L       I   +    T LH A  LG   +
Sbjct: 211 ESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQI 270

Query: 255 AIELVNAGANVNQPND-KGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMA 313
              L+    +   P+D +G TPLH AA S N A  +++ + + +  +    EG++    A
Sbjct: 271 VHLLLERNKSGTIPSDSQGATPLHYAAQS-NFAETVKVFLKHPSVKDDSDLEGRTSFMWA 329

Query: 314 AIHGR--FTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIH 371
           A  G     R+ + +++  +I+ ADK+G T LH AA  GH   +  L+ N A      + 
Sbjct: 330 AGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVM 389

Query: 372 DMFPLHLAVLFGFSDCCRKLLSSGQLYSIVS----SLSNEHVLSAGFDI----------- 416
              PL  A   G  D  + L+  G    +V     SL +   L    D+           
Sbjct: 390 KHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINP 449

Query: 417 NTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLV 476
           N  D  GRT L  AA GG + C+ +L+ + AD   +DK GRT LH++  NG       L+
Sbjct: 450 NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509

Query: 477 TAGAGVN--EADCKGCSPLHYAAASDTY 502
              A  N  E + +  +PL YA   + +
Sbjct: 510 DFAAFPNQMENNEERYTPLDYALLGERH 537



 Score =  167 bits (423), Expect = 5e-41
 Identities = 149/530 (28%), Positives = 231/530 (43%), Gaps = 36/530 (6%)

Query: 111 LHVAAANRATKCAEALAPLLSSL-NVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVC 169
           +H AA N      + L    S+L +  D+ GR+ L + V +  L+  + LL  GA +N  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 170 DKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMG 229
           D  +R  LH AA  G+   +KLL+ R A+   KD +    LH        + +  LL+  
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 230 A--EIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAA-----VS 282
           A  E+D  +    TALH + Y         L+   +N+  P+ +G  PLH AA      +
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 283 TNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGS-EIDCADKFGNT 341
            +   C+       + +N+Q  EG++PLH A   G  T   +L    S  I   D    T
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257

Query: 342 PLHVAARYGHELLISTLMT-NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQL--- 397
           PLH AA  GH  ++  L+  N + T         PLH A    F++  +  L    +   
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317

Query: 398 --------YSIVSSLSNEHVL------SAGFDINTPDNLGRTCLHAAASGGNVECLNLLL 443
                   +   +   ++ VL       +  DIN  D  G T LHAAA  G+V  + LLL
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377

Query: 444 SSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYR 503
            + A +   D    TPL  A   G      TL+  GA V+  D  G S LH+AA      
Sbjct: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437

Query: 504 RAE-----PHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAA 558
             +        P+  D     PL+ +       C+  L++N ADP+++D++G TA+H++ 
Sbjct: 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSC 497

Query: 559 AYGNRQNLELLLEMSF--NCLEDVESTIPVSPLHLAAYNGHCEALKTLAE 606
             G    ++LLL+ +   N +E+ E     +PL  A      E ++ + E
Sbjct: 498 NNGYLDAIKLLLDFAAFPNQMENNEER--YTPLDYALLGERHEVIQFMLE 545



 Score =  147 bits (370), Expect = 7e-35
 Identities = 142/520 (27%), Positives = 239/520 (45%), Gaps = 65/520 (12%)

Query: 532  CLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLE-DVESTIPVSPLH 590
            C + LL  GAD +  D    TA+H AA  GN + ++LLL    N ++ D+E    ++PLH
Sbjct: 63   CADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEE---MTPLH 119

Query: 591  LAAYNGHCEALKTLAETLV--NLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
            L   +   + L  L + +    +D +D   +TAL  +    + E V++L  H ++  I +
Sbjct: 120  LTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD 179

Query: 649  RKRKWTPLHAAAASGHTDSLHL---LIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVH 705
             + K  PLH AA      ++H    ++D+     + +  D  G+TPL  A+ +G+V  V 
Sbjct: 180  VEGK-IPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVD 238

Query: 706  LLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACG 765
            +L                       T  E C     D+           RTP+H A+  G
Sbjct: 239  VL-----------------------TSYESCNITSYDN---------LFRTPLHWAALLG 266

Query: 766  HTAVLRTLLQAALS-TDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPF---SYLEG 821
            H  ++  LL+   S T P D+     G +P+H+A+ +   + +++ L+H      S LEG
Sbjct: 267  HAQIVHLLLERNKSGTIPSDS----QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEG 322

Query: 822  NPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQ 881
               T    A     D     +L       +N  D  G T LHAAA + +VS +++LL++ 
Sbjct: 323  R--TSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380

Query: 882  AEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGH-EKC 940
            A+V+ATD    T L  A E G    ++ L+ +G A + ++D++ ++ LH A   G+ + C
Sbjct: 381  AQVDATDVMKHTPLFRACEMGHKDVIQTLI-KGGARVDLVDQDGHSLLHWAALGGNADVC 439

Query: 941  ALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALA 1000
             ++I  +       N  + A + PL  AA  G  + +  L+ + A     D+EG T AL 
Sbjct: 440  QILIENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRT-ALH 494

Query: 1001 CAPNKDVADCLALILSTMKPFP-----PKDAVSPFSFSLL 1035
             + N    D + L+L     FP      ++  +P  ++LL
Sbjct: 495  WSCNNGYLDAIKLLLD-FAAFPNQMENNEERYTPLDYALL 533



 Score =  144 bits (362), Expect = 6e-34
 Identities = 128/472 (27%), Positives = 209/472 (44%), Gaps = 23/472 (4%)

Query: 554  VHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDV 613
            VH AA  G++  L+ L+ +  + L+D E     +PL         +    L +   +++ 
Sbjct: 18   VHAAAVNGDKGALQRLI-VGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNK 76

Query: 614  RDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLID 673
             DH  RTAL LA ++G+   +++L    A+ + K+ + + TPLH          L LL+ 
Sbjct: 77   TDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLE-EMTPLHLTTRHRSPKCLALLLK 135

Query: 674  SGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGA---- 729
                 ++ D  D   QT L  +    + + V LL++  S     D+ G+  LH  A    
Sbjct: 136  FMAPGEV-DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKD 194

Query: 730  --VTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGV 787
                    C+      ++ +  +D++GRTP+H A A G+  V+  L              
Sbjct: 195  PSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCN---ITSY 251

Query: 788  DYSGYSPMHWASYTGHEDCLELLLEHSPFSYL--EGNPFTPLHCAVINNQDSTTEMLLGA 845
            D    +P+HWA+  GH   + LLLE +    +  +    TPLH A  +N   T ++ L  
Sbjct: 252  DNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311

Query: 846  LGAKIVNSRDAKGRTPLHAAA--FADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQ 903
               K  +  D +GRT    AA   +D+V    + L+   ++N  D  G TAL  AA +G 
Sbjct: 312  PSVK--DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGH 369

Query: 904  TAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQM 963
             + V+ LL    A +   D  K+T L  AC  GH+     ++     + L++    +L  
Sbjct: 370  VSTVKLLL-ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSL-- 426

Query: 964  PLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALIL 1015
             LH AA  G A V Q L+ +       D  G TP L CA      +C+A+++
Sbjct: 427  -LHWAALGGNADVCQILIENKINPNVQDYAGRTP-LQCAAYGGYINCMAVLM 476



 Score =  122 bits (307), Expect = 1e-27
 Identities = 102/327 (31%), Positives = 157/327 (48%), Gaps = 9/327 (2%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKE-NINVLDQERRTPLHAAAYVGDVPILQLLL-MSGANVN 68
           PL  A+   +V  V  L S +  NI   D   RTPLH AA +G   I+ LLL  + +   
Sbjct: 224 PLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTI 283

Query: 69  AKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128
             D+   TPLH AA S   + + + L H +  +  D   +T    AA   +      +  
Sbjct: 284 PSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS 343

Query: 129 LLSSL--NVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHL 186
           L S +  N+AD+ G +ALH A  SGH+ TV LLL   A ++  D  +  PL  A  +GH 
Sbjct: 344 LKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHK 403

Query: 187 EVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246
           +V++ L+  GA +   D+ G+ LLH AA  G  +V + L+      +  +  G T L  A
Sbjct: 404 DVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 463

Query: 247 CYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGAL-CLELLVNNGADVNY--QS 303
            Y G       L+   A+ N  + +G T LH +    NG L  ++LL++  A  N    +
Sbjct: 464 AYGGYINCMAVLMENNADPNIQDKEGRTALHWSC--NNGYLDAIKLLLDFAAFPNQMENN 521

Query: 304 KEGKSPLHMAAIHGRFTRSQILIQNGS 330
           +E  +PL  A +  R    Q ++++G+
Sbjct: 522 EERYTPLDYALLGERHEVIQFMLEHGA 548


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score =  201 bits (512), Expect = 2e-51
 Identities = 169/584 (28%), Positives = 259/584 (44%), Gaps = 62/584 (10%)

Query: 427 LHAAASGGNVECLNLLLSSGADLR-RRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEA 485
           +HAAA  G+   L  L+   + L+ + D+FGRTPL Y        CA  L+ AGA VN+ 
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 486 DCKGCSPLHYAAASDTYR-----RAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNG 540
           D    + LH AA    YR               D EE  PL  + R  +  CL  LL   
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 541 A--DPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNC-LEDVESTIPVSPLHLAAYNGH 597
           A  +   +D+   TA+H++A Y N ++++LL++   N  + DVE  IP   LH AA +  
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIP---LHWAANHKD 194

Query: 598 CEALKTL------AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651
             A+ T+      A T   L+ +D++GRT L  A   G+   V+VLT++ +  +      
Sbjct: 195 PSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254

Query: 652 KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711
             TPLH AA  GH   +HLL++  +   I    D+ G TPL  A  +   + V + L+  
Sbjct: 255 FRTPLHWAALLGHAQIVHLLLERNKSGTIPS--DSQGATPLHYAAQSNFAETVKVFLKHP 312

Query: 712 STADAADLRGRTALHRGAVTGCEDCLAALLD--HDAFVLCRDFKGRTPIHLASACGHTAV 769
           S  D +DL GRT+    A  G +D L  +L    D  +   D  G T +H A+  GH + 
Sbjct: 313 SVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVST 372

Query: 770 LRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHC 829
           ++ LL+     D      D   ++P+  A   GH+D ++ L++                 
Sbjct: 373 VKLLLENNAQVD----ATDVMKHTPLFRACEMGHKDVIQTLIK----------------- 411

Query: 830 AVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDH 889
                            G   V+  D  G + LH AA   N    ++L++++   N  D+
Sbjct: 412 -----------------GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDY 454

Query: 890 TGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQ 949
            GRT L  AA  G    +  L+    AD  + D+   TALH +C+ G+   A+ +L +  
Sbjct: 455 AGRTPLQCAAYGGYINCMAVLM-ENNADPNIQDKEGRTALHWSCNNGYLD-AIKLLLDFA 512

Query: 950 DLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEE 993
                   N     PL  A       V+Q +L HGA  +A  ++
Sbjct: 513 AFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQD 556



 Score =  171 bits (434), Expect = 3e-42
 Identities = 150/508 (29%), Positives = 229/508 (45%), Gaps = 39/508 (7%)

Query: 26  SLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASR 85
           S L  KE     DQ  RTPL        +     LL +GA+VN  D    T LH AA   
Sbjct: 38  SALKDKE-----DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKG 92

Query: 86  NEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLS--SLNVADRSGRSA 143
           N + + LLL   A+   +D    TPLH+   +R+ KC   L   ++   ++  D++ ++A
Sbjct: 93  NYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTA 152

Query: 144 LHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLE------VLKLLVARGA 197
           LH + +  + E V LL+   +++ + D + + PLHWAA   H +      V  +L A   
Sbjct: 153 LHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAA--NHKDPSAVHTVRCILDAAPT 210

Query: 198 D--LGCKDRKGYGLLHTAAASGQIEVVKYLLRM-GAEIDEPNAFGNTALHIACYLGQDAV 254
           +  L  +D +G   LH A A G + VV  L       I   +    T LH A  LG   +
Sbjct: 211 ESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQI 270

Query: 255 AIELVNAGANVNQPND-KGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMA 313
              L+    +   P+D +G TPLH AA S N A  +++ + + +  +    EG++    A
Sbjct: 271 VHLLLERNKSGTIPSDSQGATPLHYAAQS-NFAETVKVFLKHPSVKDDSDLEGRTSFMWA 329

Query: 314 AIHGR--FTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIH 371
           A  G     R+ + +++  +I+ ADK+G T LH AA  GH   +  L+ N A      + 
Sbjct: 330 AGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVM 389

Query: 372 DMFPLHLAVLFGFSDCCRKLLSSGQLYSIVS----SLSNEHVLSAGFDI----------- 416
              PL  A   G  D  + L+  G    +V     SL +   L    D+           
Sbjct: 390 KHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINP 449

Query: 417 NTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLV 476
           N  D  GRT L  AA GG + C+ +L+ + AD   +DK GRT LH++  NG       L+
Sbjct: 450 NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509

Query: 477 TAGAGVN--EADCKGCSPLHYAAASDTY 502
              A  N  E + +  +PL YA   + +
Sbjct: 510 DFAAFPNQMENNEERYTPLDYALLGERH 537



 Score =  167 bits (423), Expect = 5e-41
 Identities = 149/530 (28%), Positives = 231/530 (43%), Gaps = 36/530 (6%)

Query: 111 LHVAAANRATKCAEALAPLLSSL-NVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVC 169
           +H AA N      + L    S+L +  D+ GR+ L + V +  L+  + LL  GA +N  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 170 DKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMG 229
           D  +R  LH AA  G+   +KLL+ R A+   KD +    LH        + +  LL+  
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 230 A--EIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAA-----VS 282
           A  E+D  +    TALH + Y         L+   +N+  P+ +G  PLH AA      +
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 283 TNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGS-EIDCADKFGNT 341
            +   C+       + +N+Q  EG++PLH A   G  T   +L    S  I   D    T
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257

Query: 342 PLHVAARYGHELLISTLMT-NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQL--- 397
           PLH AA  GH  ++  L+  N + T         PLH A    F++  +  L    +   
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317

Query: 398 --------YSIVSSLSNEHVL------SAGFDINTPDNLGRTCLHAAASGGNVECLNLLL 443
                   +   +   ++ VL       +  DIN  D  G T LHAAA  G+V  + LLL
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377

Query: 444 SSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYR 503
            + A +   D    TPL  A   G      TL+  GA V+  D  G S LH+AA      
Sbjct: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437

Query: 504 RAE-----PHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAA 558
             +        P+  D     PL+ +       C+  L++N ADP+++D++G TA+H++ 
Sbjct: 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSC 497

Query: 559 AYGNRQNLELLLEMSF--NCLEDVESTIPVSPLHLAAYNGHCEALKTLAE 606
             G    ++LLL+ +   N +E+ E     +PL  A      E ++ + E
Sbjct: 498 NNGYLDAIKLLLDFAAFPNQMENNEER--YTPLDYALLGERHEVIQFMLE 545



 Score =  147 bits (370), Expect = 7e-35
 Identities = 142/520 (27%), Positives = 239/520 (45%), Gaps = 65/520 (12%)

Query: 532  CLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLE-DVESTIPVSPLH 590
            C + LL  GAD +  D    TA+H AA  GN + ++LLL    N ++ D+E    ++PLH
Sbjct: 63   CADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEE---MTPLH 119

Query: 591  LAAYNGHCEALKTLAETLV--NLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
            L   +   + L  L + +    +D +D   +TAL  +    + E V++L  H ++  I +
Sbjct: 120  LTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD 179

Query: 649  RKRKWTPLHAAAASGHTDSLHL---LIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVH 705
             + K  PLH AA      ++H    ++D+     + +  D  G+TPL  A+ +G+V  V 
Sbjct: 180  VEGK-IPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVD 238

Query: 706  LLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACG 765
            +L                       T  E C     D+           RTP+H A+  G
Sbjct: 239  VL-----------------------TSYESCNITSYDN---------LFRTPLHWAALLG 266

Query: 766  HTAVLRTLLQAALS-TDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPF---SYLEG 821
            H  ++  LL+   S T P D+     G +P+H+A+ +   + +++ L+H      S LEG
Sbjct: 267  HAQIVHLLLERNKSGTIPSDS----QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEG 322

Query: 822  NPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQ 881
               T    A     D     +L       +N  D  G T LHAAA + +VS +++LL++ 
Sbjct: 323  R--TSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380

Query: 882  AEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGH-EKC 940
            A+V+ATD    T L  A E G    ++ L+ +G A + ++D++ ++ LH A   G+ + C
Sbjct: 381  AQVDATDVMKHTPLFRACEMGHKDVIQTLI-KGGARVDLVDQDGHSLLHWAALGGNADVC 439

Query: 941  ALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALA 1000
             ++I  +       N  + A + PL  AA  G  + +  L+ + A     D+EG T AL 
Sbjct: 440  QILIENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRT-ALH 494

Query: 1001 CAPNKDVADCLALILSTMKPFP-----PKDAVSPFSFSLL 1035
             + N    D + L+L     FP      ++  +P  ++LL
Sbjct: 495  WSCNNGYLDAIKLLLD-FAAFPNQMENNEERYTPLDYALL 533



 Score =  144 bits (362), Expect = 6e-34
 Identities = 128/472 (27%), Positives = 209/472 (44%), Gaps = 23/472 (4%)

Query: 554  VHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDV 613
            VH AA  G++  L+ L+ +  + L+D E     +PL         +    L +   +++ 
Sbjct: 18   VHAAAVNGDKGALQRLI-VGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNK 76

Query: 614  RDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLID 673
             DH  RTAL LA ++G+   +++L    A+ + K+ + + TPLH          L LL+ 
Sbjct: 77   TDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLE-EMTPLHLTTRHRSPKCLALLLK 135

Query: 674  SGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGA---- 729
                 ++ D  D   QT L  +    + + V LL++  S     D+ G+  LH  A    
Sbjct: 136  FMAPGEV-DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKD 194

Query: 730  --VTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGV 787
                    C+      ++ +  +D++GRTP+H A A G+  V+  L              
Sbjct: 195  PSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCN---ITSY 251

Query: 788  DYSGYSPMHWASYTGHEDCLELLLEHSPFSYL--EGNPFTPLHCAVINNQDSTTEMLLGA 845
            D    +P+HWA+  GH   + LLLE +    +  +    TPLH A  +N   T ++ L  
Sbjct: 252  DNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311

Query: 846  LGAKIVNSRDAKGRTPLHAAA--FADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQ 903
               K  +  D +GRT    AA   +D+V    + L+   ++N  D  G TAL  AA +G 
Sbjct: 312  PSVK--DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGH 369

Query: 904  TAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQM 963
             + V+ LL    A +   D  K+T L  AC  GH+     ++     + L++    +L  
Sbjct: 370  VSTVKLLL-ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSL-- 426

Query: 964  PLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALIL 1015
             LH AA  G A V Q L+ +       D  G TP L CA      +C+A+++
Sbjct: 427  -LHWAALGGNADVCQILIENKINPNVQDYAGRTP-LQCAAYGGYINCMAVLM 476



 Score =  122 bits (307), Expect = 1e-27
 Identities = 102/327 (31%), Positives = 157/327 (48%), Gaps = 9/327 (2%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKE-NINVLDQERRTPLHAAAYVGDVPILQLLL-MSGANVN 68
           PL  A+   +V  V  L S +  NI   D   RTPLH AA +G   I+ LLL  + +   
Sbjct: 224 PLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTI 283

Query: 69  AKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128
             D+   TPLH AA S   + + + L H +  +  D   +T    AA   +      +  
Sbjct: 284 PSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS 343

Query: 129 LLSSL--NVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHL 186
           L S +  N+AD+ G +ALH A  SGH+ TV LLL   A ++  D  +  PL  A  +GH 
Sbjct: 344 LKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHK 403

Query: 187 EVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246
           +V++ L+  GA +   D+ G+ LLH AA  G  +V + L+      +  +  G T L  A
Sbjct: 404 DVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 463

Query: 247 CYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGAL-CLELLVNNGADVNY--QS 303
            Y G       L+   A+ N  + +G T LH +    NG L  ++LL++  A  N    +
Sbjct: 464 AYGGYINCMAVLMENNADPNIQDKEGRTALHWSC--NNGYLDAIKLLLDFAAFPNQMENN 521

Query: 304 KEGKSPLHMAAIHGRFTRSQILIQNGS 330
           +E  +PL  A +  R    Q ++++G+
Sbjct: 522 EERYTPLDYALLGERHEVIQFMLEHGA 548


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  187 bits (474), Expect = 6e-47
 Identities = 125/370 (33%), Positives = 187/370 (50%), Gaps = 1/370 (0%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           PL   +    VE+VR LL+ + +++       TPL  AA      +  LLL  GA+ N  
Sbjct: 365 PLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRV 424

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
           D     PLH AA + ++    LLL H A V+A+++   TPLH+AA N     A  L    
Sbjct: 425 DEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQ 484

Query: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190
           +  N+ +  G++ LH A + GH+  V LL ++GA L+   +  R PLH A   G +  ++
Sbjct: 485 ADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQ 544

Query: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250
            L+  GA     D+ GYG LHTAAA G+  + K LLR GA ++ P   G T LH+A Y G
Sbjct: 545 HLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKG 604

Query: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310
              +   L  + AN+       +TPLH+AA     A+ +  L+  GAD N   + G +PL
Sbjct: 605 HLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAV-VSALLQCGADPNAAEQSGWTPL 663

Query: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGI 370
           H+A     F     L+++ + +   +K G TP H+AA  G+  ++  L+  GA    +  
Sbjct: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDG 723

Query: 371 HDMFPLHLAV 380
               PL LA+
Sbjct: 724 VSCTPLQLAL 733



 Score =  174 bits (441), Expect = 4e-43
 Identities = 118/384 (30%), Positives = 193/384 (50%), Gaps = 7/384 (1%)

Query: 28  LSQKENINVLDQE------RRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRA 81
           LS ++N+   D+E      + TPLH     G V  ++LLL    +V+ +     TPL  A
Sbjct: 343 LSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIA 402

Query: 82  AASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGR 141
           A  +   +  LLLAH AD N  D+    PLH AA N     A  L    + ++  +R G 
Sbjct: 403 AQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGW 462

Query: 142 SALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGC 201
           + LH A  +       LL+++ A  N+ + + + PLH AA+ GH+ ++KLL ++GA+L  
Sbjct: 463 TPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDA 522

Query: 202 KDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNA 261
           + R     LH A   G++  +++LL+ GA  D  +  G   LH A   G+  +   L+  
Sbjct: 523 QQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRY 582

Query: 262 GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTR 321
           GA++  P  +G+TPLH+AA   +  + + LL  + A++        +PLH+AA HG    
Sbjct: 583 GASLELPTHQGWTPLHLAAYKGHLEI-IHLLAESHANMGALGAVNWTPLHLAARHGEEAV 641

Query: 322 SQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVL 381
              L+Q G++ + A++ G TPLH+A +    L +  L+ + A+   R      P HLA L
Sbjct: 642 VSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAAL 701

Query: 382 FGFSDCCRKLLSSGQLYSIVSSLS 405
            G +   + L+ +G    +   +S
Sbjct: 702 KGNTAILKVLVEAGAQLDVQDGVS 725



 Score =  150 bits (379), Expect = 6e-36
 Identities = 118/365 (32%), Positives = 171/365 (46%), Gaps = 11/365 (3%)

Query: 425 TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE 484
           T LH   + G+VE + LLL+   D+  +   G TPL  AA +        L+  GA  N 
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 485 ADCKGCSPLHYAAAS--DTYRRAEPHTPSSHDAEEDE---PLKESRRKEAFFCLEFLLDN 539
            D  G +PLH+AA +  D   R      +  DA+E E   PL  + +         L+  
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483

Query: 540 GADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCE 599
            ADP+L + +G T +H AA +G+   ++LL         D +     +PLHLA   G   
Sbjct: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAEL--DAQQRNLRTPLHLAVERGKVR 541

Query: 600 ALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAA 659
           A++ L ++    D  D  G   L  A  RG     ++L  +GAS  +   +  WTPLH A
Sbjct: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQG-WTPLHLA 600

Query: 660 AASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADL 719
           A  GH + +HLL +S         + A   TPL LA  +G    V  LL+ G+  +AA+ 
Sbjct: 601 AYKGHLEIIHLLAESHANMG---ALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657

Query: 720 RGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALS 779
            G T LH          +  LL+H A V  R+  G TP HLA+  G+TA+L+ L++A   
Sbjct: 658 SGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQ 717

Query: 780 TDPLD 784
            D  D
Sbjct: 718 LDVQD 722



 Score =  146 bits (368), Expect = 1e-34
 Identities = 126/423 (29%), Positives = 185/423 (43%), Gaps = 53/423 (12%)

Query: 274 TPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEID 333
           TPLH   V+      + LL+ +  DV+ Q+  G +PL +AA   +     +L+ +G++ +
Sbjct: 364 TPLHFL-VAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422

Query: 334 CADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLS 393
             D+ G  PLH AA+ G +     L+ +GA    +      PLHLA    F +  R L+S
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482

Query: 394 SGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRD 453
                                D N  +  G+T LH AA  G+V  + LL S GA+L  + 
Sbjct: 483 RQA------------------DPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQ 524

Query: 454 KFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSH 513
           +  RTPLH A   G  +    L+ +GA  +  D  G  PLH AAA   Y           
Sbjct: 525 RNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY----------- 573

Query: 514 DAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMS 573
                               + LL  GA   L   QG+T +H AA  G+ + + LL E  
Sbjct: 574 -----------------LICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESH 616

Query: 574 FNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTEC 633
            N        +  +PLHLAA +G    +  L +   + +  +  G T L LA +R +   
Sbjct: 617 ANM--GALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLS 674

Query: 634 VEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLM 693
           V  L  H A+   +  K  WTP H AA  G+T  L +L+++G +    DV D    TPL 
Sbjct: 675 VINLLEHHANVHAR-NKVGWTPAHLAALKGNTAILKVLVEAGAQ---LDVQDGVSCTPLQ 730

Query: 694 LAI 696
           LA+
Sbjct: 731 LAL 733



 Score =  142 bits (357), Expect = 2e-33
 Identities = 119/382 (31%), Positives = 177/382 (46%), Gaps = 14/382 (3%)

Query: 552 TAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNL 611
           T +H+  A G+ + + LLL    +   D ++    +PL +AA +   +    L     + 
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDV--DCQTASGYTPLLIAAQDQQPDLCALLLAHGADA 421

Query: 612 DVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLL 671
           +  D  G   L  A + G      +L  HGA    +ER+  WTPLH AA +   +   LL
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREG-WTPLHLAAQNNFENVARLL 480

Query: 672 IDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVT 731
           +    +AD  ++ +A G+TPL +A   GHV  V LL  +G+  DA     RT LH     
Sbjct: 481 VS--RQAD-PNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537

Query: 732 GCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSG 791
           G    +  LL   A     D  G  P+H A+A G   + + LL+   S +       + G
Sbjct: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLEL----PTHQG 593

Query: 792 YSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKI 850
           ++P+H A+Y GH + + LL E H+    L    +TPLH A  + +++    LL   GA  
Sbjct: 594 WTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQC-GAD- 651

Query: 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910
            N+ +  G TPLH A        +  LL+H A V+A +  G T    AA  G TA ++ L
Sbjct: 652 PNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVL 711

Query: 911 LYRGKADLTVLDENKNTALHLA 932
           +  G A L V D    T L LA
Sbjct: 712 VEAG-AQLDVQDGVSCTPLQLA 732



 Score =  132 bits (333), Expect = 1e-30
 Identities = 113/412 (27%), Positives = 175/412 (42%), Gaps = 46/412 (11%)

Query: 586 VSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL 645
           V+PLH     G  E ++ L    V++D +   G T L +A +    +   +L AHGA A 
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422

Query: 646 IKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVH 705
            +  +  W PLH AA +G   +  LL+D G      D  +  G TPL LA  N   +   
Sbjct: 423 -RVDEDGWAPLHFAAQNGDDGTARLLLDHGA---CVDAQEREGWTPLHLAAQNNFENVAR 478

Query: 706 LLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACG 765
           LL+ + +  +  +  G+T LH  A  G    +  L    A +  +    RTP+HLA   G
Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERG 538

Query: 766 HTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFT 825
               ++ LL++    D LD     SGY P+H A+  G     ++LL +     L      
Sbjct: 539 KVRAIQHLLKSGAVPDALDQ----SGYGPLHTAAARGKYLICKMLLRYGASLEL------ 588

Query: 826 PLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVN 885
           P H                            +G TPLH AA+  ++  + +L +  A + 
Sbjct: 589 PTH----------------------------QGWTPLHLAAYKGHLEIIHLLAESHANMG 620

Query: 886 ATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMIL 945
           A      T L  AA +G+ A V  LL  G AD    +++  T LHLA  +      + +L
Sbjct: 621 ALGAVNWTPLHLAARHGEEAVVSALLQCG-ADPNAAEQSGWTPLHLAVQRSTFLSVINLL 679

Query: 946 AETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
               +   ++A N     P H+AA  G  ++++ L+  GA +   D    TP
Sbjct: 680 EHHAN---VHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTP 728



 Score =  131 bits (330), Expect = 3e-30
 Identities = 114/366 (31%), Positives = 162/366 (44%), Gaps = 14/366 (3%)

Query: 650  KRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLE 709
            + K TPLH   A G  + + LL+      D+ D   A G TPL++A  +   D   LLL 
Sbjct: 360  ENKVTPLHFLVAQGSVEQVRLLL--AHEVDV-DCQTASGYTPLLIAAQDQQPDLCALLLA 416

Query: 710  KGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAV 769
             G+ A+  D  G   LH  A  G +     LLDH A V  ++ +G TP+HLA+      V
Sbjct: 417  HGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENV 476

Query: 770  LRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLL-EHSPFSYLEGNPFTPLH 828
             R L+      +  +A     G +P+H A+Y GH   ++LL  + +     + N  TPLH
Sbjct: 477  ARLLVSRQADPNLHEA----EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLH 532

Query: 829  CAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATD 888
             AV   +    + LL +    + ++ D  G  PLH AA        +MLL++ A +    
Sbjct: 533  LAVERGKVRAIQHLLKS--GAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPT 590

Query: 889  HTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAET 948
            H G T L  AA  G    +  LL    A++  L     T LHLA   G E     +L   
Sbjct: 591  HQGWTPLHLAAYKGHLEIIH-LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCG 649

Query: 949  QDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVA 1008
             D    NA   +   PLH+A +      V  LL H A V A ++ G TPA   A   + A
Sbjct: 650  AD---PNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTA 706

Query: 1009 DCLALI 1014
                L+
Sbjct: 707  ILKVLV 712



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 68/215 (31%), Positives = 102/215 (47%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           PL  A+    V  ++ LL      + LDQ    PLH AA  G   I ++LL  GA++   
Sbjct: 530 PLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP 589

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
                TPLH AA   + +++ LL    A++ A   +  TPLH+AA +       AL    
Sbjct: 590 THQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCG 649

Query: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190
           +  N A++SG + LH AV      +V  LL   A+++  +K    P H AA  G+  +LK
Sbjct: 650 ADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILK 709

Query: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYL 225
           +LV  GA L  +D      L  A  S +  ++ +L
Sbjct: 710 VLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 49/156 (31%), Positives = 72/156 (46%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           PL  A +   +E +  L     N+  L     TPLH AA  G+  ++  LL  GA+ NA 
Sbjct: 596 PLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAA 655

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
           +    TPLH A        +  LL H A+V+AR+K+  TP H+AA    T   + L    
Sbjct: 656 EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAG 715

Query: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASL 166
           + L+V D    + L  A+ S     ++ L  K  S+
Sbjct: 716 AQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSV 751



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 37/118 (31%), Positives = 56/118 (47%)

Query: 1   MGILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLL 60
           MG L   +  PL  A    +   V +LL    + N  +Q   TPLH A        +  L
Sbjct: 619 MGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINL 678

Query: 61  LMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANR 118
           L   ANV+A++ +  TP H AA   N  +L +L+   A ++ +D +  TPL +A  +R
Sbjct: 679 LEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSR 736


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  175 bits (443), Expect = 2e-43
 Identities = 149/480 (31%), Positives = 230/480 (47%), Gaps = 23/480 (4%)

Query: 7   TDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGAN 66
           +D   L +A    DV  VR LL +  ++N   +E  + L  A   G   + Q+LL   AN
Sbjct: 233 SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 292

Query: 67  VNAKDTLW-LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEA 125
           V  +     +TPL  AA   + K++ LLLAH ADVNA+     T L  A A       + 
Sbjct: 293 VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKV 352

Query: 126 LAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV-CDKKERQPLHWAAFLG 184
           L    +S+   + +G + L  A  +GH+E   LLL  GA +N   ++ +   L  A + G
Sbjct: 353 LLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKG 412

Query: 185 HLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALH 244
           HLE+++ L+  GAD   K  + +  L  A   G +EV + LL  GA+++ P     + L 
Sbjct: 413 HLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 472

Query: 245 IACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSK 304
           +A   G   +A  L+  GA++ + ND+G+TPL  AA   +  + + LL+  GA++N Q++
Sbjct: 473 LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM-VALLLGQGANINAQTE 531

Query: 305 E-GKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGA 363
           E  ++ L +A   G    +  LI+ G++I+      +TPL  AA+ GH  L+  L+  GA
Sbjct: 532 ETQETALTLACCGGFLEVADFLIKAGADIELG---CSTPLMEAAQEGHLELVKYLLAAGA 588

Query: 364 DTARRGIHDMFPLHLAVLFGFSDCCRKLL---------SSGQLYSIVSSLSNEHV----- 409
           +           L  A   G +D    LL         S G    ++ +    HV     
Sbjct: 589 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648

Query: 410 -LSAGFDIN-TPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANG 467
            +S G ++N T  N   T L  A +GG++  + LLL+ GAD   R K G T L  AA  G
Sbjct: 649 LISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 708



 Score =  143 bits (361), Expect = 8e-34
 Identities = 145/510 (28%), Positives = 219/510 (42%), Gaps = 84/510 (16%)

Query: 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCD---KKERQPLHWAAFLGHLEV 188
           S+N     G S L  A  +G+ E   +LL   A  NV D   K +  PL  AA  GH+++
Sbjct: 259 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHA--NVEDRGIKGDITPLMAAANGGHVKI 316

Query: 189 LKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNT------- 241
           +KLL+A  AD+  +   G   L  A A G ++VVK LL  GA I++ N  G+T       
Sbjct: 317 VKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGS 376

Query: 242 ---------------------------ALHIACYLGQDAVAIELVNAGANVNQPNDKGFT 274
                                      AL +ACY G   +   L+ AGA+     D+  T
Sbjct: 377 AGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHT 436

Query: 275 PLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDC 334
            L  A +  +  +   LL+++GA VN  +   +SPL +AA  G    + +LI+ G+ ++ 
Sbjct: 437 ALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEE 495

Query: 335 ADKFGNTPLHVAARYGHELLISTLMTNGAD-TARRGIHDMFPLHLAVLFGFSDCCRKLLS 393
            +  G TPL  AAR GHE +++ L+  GA+  A+        L LA   GF +    L+ 
Sbjct: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIK 555

Query: 394 SGQLYSIVSSLS------------NEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNL 441
           +G    +  S               +++L+AG +++     G T L  A   G+ +  ++
Sbjct: 556 AGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADV 615

Query: 442 LLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDT 501
           LL +GADL    + GRTPL  AA  G       L++ GA VN              A++ 
Sbjct: 616 LLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR-----------TTANND 664

Query: 502 YRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYG 561
           +          H A                 +E LL +GADP+ R + G T +  AA  G
Sbjct: 665 HTVLSLACAGGHLA----------------VVELLLAHGADPTHRLKDGSTMLIEAAKGG 708

Query: 562 NRQNLELLLEMSFNCLE----DVESTIPVS 587
           +   +  LL+   N L     DV    P S
Sbjct: 709 HTSVVCYLLDYPNNLLSAPPPDVTQLTPPS 738



 Score =  133 bits (335), Expect = 8e-31
 Identities = 146/529 (27%), Positives = 225/529 (42%), Gaps = 47/529 (8%)

Query: 493 LHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYT 552
           L  AAA+ T  RAE  + ++    ++  L E+  +     +  LL  G   +    +G +
Sbjct: 212 LDEAAAALTRMRAE--STANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGES 269

Query: 553 AVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLD 612
            +  A + G  +  ++LL M  N +ED      ++PL  AA  GH + +K L     +++
Sbjct: 270 LLCLACSAGYYELAQVLLAMHAN-VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVN 328

Query: 613 VRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLI 672
            +   G TAL  A   G  + V+VL   GAS +    +   TPL  A ++GH +   LL+
Sbjct: 329 AQSSTGNTALTYACAGGYVDVVKVLLESGAS-IEDHNENGHTPLMEAGSAGHVEVARLLL 387

Query: 673 DSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTG 732
           ++G  A I    + + ++ L LA   GH++ V  LLE G+  +       TAL    + G
Sbjct: 388 ENG--AGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDG 445

Query: 733 CEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGY 792
             +    LLD  A V        +P+ LA+  GH  +   L++   S +     V+  GY
Sbjct: 446 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEE----VNDEGY 501

Query: 793 SPMHWASYTGHEDCLELLLEHSPF-------------------SYLEGNPF--------- 824
           +P+  A+  GHE+ + LLL                         +LE   F         
Sbjct: 502 TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE 561

Query: 825 ----TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQH 880
               TPL  A         + LL A GA  V++  A G T L  A    +     +LLQ 
Sbjct: 562 LGCSTPLMEAAQEGHLELVKYLLAA-GAN-VHATTATGDTALTYACENGHTDVADVLLQA 619

Query: 881 QAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKC 940
            A++      GRT LM AA  G    V+FL+ +G         N +T L LAC+ GH   
Sbjct: 620 GADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAV 679

Query: 941 ALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLA 989
             ++LA   D        S +   L  AA+ G  SVV  LL +   +L+
Sbjct: 680 VELLLAHGADPTHRLKDGSTM---LIEAAKGGHTSVVCYLLDYPNNLLS 725



 Score =  133 bits (334), Expect = 1e-30
 Identities = 143/498 (28%), Positives = 218/498 (43%), Gaps = 28/498 (5%)

Query: 197 ADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAI 256
           A+ G  D +    L  A + G +  V+ LL  G  ++E    G + L +AC  G   +A 
Sbjct: 228 ANAGQSDNRS---LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQ 284

Query: 257 ELVNAGANVNQPNDKG-FTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAI 315
            L+   ANV     KG  TPL +AA +      ++LL+ + ADVN QS  G + L  A  
Sbjct: 285 VLLAMHANVEDRGIKGDITPL-MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACA 343

Query: 316 HGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD-TARRGIHDMF 374
            G     ++L+++G+ I+  ++ G+TPL  A   GH  +   L+ NGA            
Sbjct: 344 GGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKES 403

Query: 375 PLHLAVLFGFSDCCRKLLSSG---------QLYSIVSSLSNEHV------LSAGFDINTP 419
            L LA   G  +  R LL +G            +++ +  + HV      L +G  +N P
Sbjct: 404 ALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP 463

Query: 420 DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAG 479
            +   + L  AA GG+VE   LL+  GA L   +  G TPL  AA  G  +    L+  G
Sbjct: 464 ADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQG 523

Query: 480 AGVN-EADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEE--DEPLKESRRKEAFFCLEFL 536
           A +N + +    + L  A        A+    +  D E     PL E+ ++     +++L
Sbjct: 524 ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYL 583

Query: 537 LDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNG 596
           L  GA+       G TA+ YA   G+    ++LL+   +   + ES    +PL  AA  G
Sbjct: 584 LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADL--EHESEGGRTPLMKAARAG 641

Query: 597 HCEALKTLAETLVNLD-VRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTP 655
           H   ++ L     N++    +   T L LA   G    VE+L AHGA       K   T 
Sbjct: 642 HVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP-THRLKDGSTM 700

Query: 656 LHAAAASGHTDSLHLLID 673
           L  AA  GHT  +  L+D
Sbjct: 701 LIEAAKGGHTSVVCYLLD 718



 Score =  128 bits (321), Expect = 3e-29
 Identities = 119/394 (30%), Positives = 175/394 (44%), Gaps = 46/394 (11%)

Query: 5   SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSG 64
           S T    L  A     V+ V+ LL    +I   ++   TPL  A   G V + +LLL +G
Sbjct: 331 SSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENG 390

Query: 65  ANVNA----------------------------------KDTLWLTPLHRAAASRNEKVL 90
           A +N                                   K     T L  A    + +V 
Sbjct: 391 AGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 450

Query: 91  GLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHS 150
            LLL   A VN     +++PL +AA     + A  L    +SL   +  G + L  A   
Sbjct: 451 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAARE 510

Query: 151 GHLETVNLLLNKGASLNV-CDKKERQPLHWAAFLGHLEVLKLLVARGAD--LGCKDRKGY 207
           GH E V LLL +GA++N   ++ +   L  A   G LEV   L+  GAD  LGC      
Sbjct: 511 GHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTP--- 567

Query: 208 GLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQ 267
             L  AA  G +E+VKYLL  GA +    A G+TAL  AC  G   VA  L+ AGA++  
Sbjct: 568 --LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625

Query: 268 PNDKGFTPLHVAAVSTNGALC-LELLVNNGADVN-YQSKEGKSPLHMAAIHGRFTRSQIL 325
            ++ G TPL  AA +  G +C ++ L++ GA+VN   +    + L +A   G     ++L
Sbjct: 626 ESEGGRTPLMKAARA--GHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELL 683

Query: 326 IQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 359
           + +G++     K G+T L  AA+ GH  ++  L+
Sbjct: 684 LAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717



 Score =  127 bits (319), Expect = 6e-29
 Identities = 102/323 (31%), Positives = 158/323 (48%), Gaps = 7/323 (2%)

Query: 43   TPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNA 102
            T L  A   G   ++Q LL  GA++  +D    TPL  AA + +  V+ +LL + AD+ A
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 103  R-DKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLN 161
            + ++   TPL +A +    +  E L    ++    + S  + L  A   G++  + +LLN
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204

Query: 162  KGASLN--VCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCK-DRKGYGLLHTAAASGQ 218
             GA +N     K    PL  AA  GH   +KLL+  G+D+  + +      L  A   G+
Sbjct: 1205 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1264

Query: 219  IEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQP--NDKGFTPL 276
             EVV  LL   A ++     G T L  A   G   V   L++ GA+VN P       T L
Sbjct: 1265 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1324

Query: 277  HVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCAD 336
             +AA   +   C ELL+  GA ++ ++K+G +PL +AA  G     Q+L+Q G+++D AD
Sbjct: 1325 TIAADKGHYKFC-ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1383

Query: 337  KFGNTPLHVAARYGHELLISTLM 359
                TPL  A R GH  ++  L+
Sbjct: 1384 NRKITPLMAAFRKGHVKVVRYLV 1406



 Score =  118 bits (296), Expect = 3e-26
 Identities = 110/377 (29%), Positives = 169/377 (44%), Gaps = 59/377 (15%)

Query: 125  ALAPLLSSLNV---ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAA 181
            A+ P+  ++++    + +  +AL  A   GH E V  LL +GAS+   DKK   PL  AA
Sbjct: 1065 AMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAA 1124

Query: 182  FLGHLEVLKLLVARGADLGCK-DRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGN 240
              GH+ V+++L+  GAD+  + +R     L  A + G+ EVV+ LL  GA  +  N    
Sbjct: 1125 TAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY 1184

Query: 241  TALHIACYLGQDAVAIELVNAGANVNQPNDK--GFTPLHVAAVSTNGALCLELLVNNGAD 298
            T L +A   G   +   L+NAGA +N       G +PL +AA++ + A  ++LL++ G+D
Sbjct: 1185 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTA-AVKLLLDMGSD 1243

Query: 299  VNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
            +N Q +  +                                NT L +A   G   ++S L
Sbjct: 1244 INAQIETNR--------------------------------NTALTLACFQGRTEVVSLL 1271

Query: 359  MTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINT 418
            +   A+   R    + PL  A   G+++  R LL  G                   D+N 
Sbjct: 1272 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA------------------DVNA 1313

Query: 419  P--DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLV 476
            P   +   T L  AA  G+ +   LL+  GA +  R+K G TPL  AA  G       LV
Sbjct: 1314 PPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373

Query: 477  TAGAGVNEADCKGCSPL 493
             AGA V+ AD +  +PL
Sbjct: 1374 QAGADVDAADNRKITPL 1390



 Score =  116 bits (290), Expect = 1e-25
 Identities = 101/313 (32%), Positives = 158/313 (50%), Gaps = 9/313 (2%)

Query: 22   EEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK-DTLWLTPLHR 80
            E V++LL +  +I   D++  TPL  AA  G V ++++LL +GA++ A+ +    TPL  
Sbjct: 1097 ELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSL 1156

Query: 81   AAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLN--VADR 138
            A +   ++V+ LLLA  A+   R+    TPL +AA+       + L    + +N     +
Sbjct: 1157 ACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSK 1216

Query: 139  SGRSALHHAVHSGHLETVNLLLNKGASLNV-CDKKERQPLHWAAFLGHLEVLKLLVARGA 197
             G S L  A  +GH   V LLL+ G+ +N   +      L  A F G  EV+ LL+ R A
Sbjct: 1217 LGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKA 1276

Query: 198  DLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEP--NAFGNTALHIACYLGQDAVA 255
            ++  + + G   L  AA+ G  EV + LL  GA+++ P   +  +TAL IA   G     
Sbjct: 1277 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1336

Query: 256  IELVNAGANVNQPNDKGFTPLHVAAVSTNGAL-CLELLVNNGADVNYQSKEGKSPLHMAA 314
              L+  GA+++  N KG TPL +AA    G L  ++LLV  GADV+       +PL  A 
Sbjct: 1337 ELLIGRGAHIDVRNKKGNTPLWLAA--NGGHLDVVQLLVQAGADVDAADNRKITPLMAAF 1394

Query: 315  IHGRFTRSQILIQ 327
              G     + L++
Sbjct: 1395 RKGHVKVVRYLVK 1407



 Score =  114 bits (285), Expect = 5e-25
 Identities = 107/371 (28%), Positives = 169/371 (45%), Gaps = 51/371 (13%)

Query: 240  NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299
            +TAL +AC  G + +   L+  GA++   + KGFTPL +AA + +  + +E+L++NGAD+
Sbjct: 1084 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV-VEILLDNGADI 1142

Query: 300  NYQSKEGK-SPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
              QS+  K +PL +A   GR    ++L+  G+  +  +    TPL +AA  G+  +I  L
Sbjct: 1143 EAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1202

Query: 359  MTNGAD-TARRGIH-DMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDI 416
            +  GA+  +R G    + PL LA + G +   + LL  G                   DI
Sbjct: 1203 LNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS------------------DI 1244

Query: 417  NTPDNLGR-TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTL 475
            N      R T L  A   G  E ++LLL   A++  R K G TPL  AA+ G  +    L
Sbjct: 1245 NAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1304

Query: 476  VTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEF 535
            +  GA VN                       P  PSS D        +   K   FC E 
Sbjct: 1305 LDKGADVN----------------------APPVPSSRDTALTIAADKGHYK---FC-EL 1338

Query: 536  LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYN 595
            L+  GA   +R+++G T +  AA  G+   ++LL++   +   D      ++PL  A   
Sbjct: 1339 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADV--DAADNRKITPLMAAFRK 1396

Query: 596  GHCEALKTLAE 606
            GH + ++ L +
Sbjct: 1397 GHVKVVRYLVK 1407



 Score =  112 bits (279), Expect = 2e-24
 Identities = 103/353 (29%), Positives = 154/353 (43%), Gaps = 32/353 (9%)

Query: 425  TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE 484
            T L  A +GG+ E +  LL  GA +  RDK G TPL  AA  G       L+  GA +  
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE- 1143

Query: 485  ADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544
                                      +  +  +D PL  +        +E LL  GA+  
Sbjct: 1144 --------------------------AQSERTKDTPLSLACSGGRQEVVELLLARGANKE 1177

Query: 545  LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTL 604
             R+   YT +  AA+ G    +++LL           S + +SPL LAA NGH  A+K L
Sbjct: 1178 HRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 1237

Query: 605  AETLVNLDVRDHKGR-TALFLATERGSTECVEVLTAHGASALIKER-KRKWTPLHAAAAS 662
             +   +++ +    R TAL LA  +G TE V +L    A+  ++ R K   TPL  AA+ 
Sbjct: 1238 LDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKAN--VEHRAKTGLTPLMEAASG 1295

Query: 663  GHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGR 722
            G+ +   +L+D G   +   V  +   T L +A   GH     LL+ +G+  D  + +G 
Sbjct: 1296 GYAEVGRVLLDKGADVNAPPVPSSR-DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGN 1354

Query: 723  TALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQ 775
            T L   A  G  D +  L+   A V   D +  TP+  A   GH  V+R L++
Sbjct: 1355 TPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407



 Score =  109 bits (272), Expect = 2e-23
 Identities = 111/385 (28%), Positives = 171/385 (44%), Gaps = 27/385 (7%)

Query: 654  TPLHAAAAS---GHTDSLHLLIDSGERADITDVMDAYGQTP------LMLAIMNGHVDCV 704
            TP H+ AAS     T +   +I       I   +D   QT       L LA   GH + V
Sbjct: 1040 TPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELV 1099

Query: 705  HLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGR-TPIHLASA 763
              LLE+G++ +  D +G T L   A  G    +  LLD+ A +  +  + + TP+ LA +
Sbjct: 1100 QTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACS 1159

Query: 764  CGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGN 822
             G   V+  LL    + +  +     S Y+P+  A+  G+ + +++LL   +  +   G+
Sbjct: 1160 GGRQEVVELLLARGANKEHRNV----SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGS 1215

Query: 823  P--FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQH 880
                +PL  A +N   +  ++LL  +G+ I    +    T L  A F      + +LL  
Sbjct: 1216 KLGISPLMLAAMNGHTAAVKLLLD-MGSDINAQIETNRNTALTLACFQGRTEVVSLLLDR 1274

Query: 881  QAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTV--LDENKNTALHLACSKGHE 938
            +A V     TG T LM AA  G       LL +G AD+    +  +++TAL +A  KGH 
Sbjct: 1275 KANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKG-ADVNAPPVPSSRDTALTIAADKGHY 1333

Query: 939  K-CALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
            K C L+I         I+  N     PL +AA  G   VVQ L+  GA V A D    TP
Sbjct: 1334 KFCELLIGRGAH----IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP 1389

Query: 998  ALACAPNKDVADCLALILSTMKPFP 1022
             +A A  K     +  ++  +  FP
Sbjct: 1390 LMA-AFRKGHVKVVRYLVKEVNQFP 1413



 Score =  105 bits (263), Expect = 2e-22
 Identities = 103/358 (28%), Positives = 150/358 (41%), Gaps = 73/358 (20%)

Query: 589  LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
            L LA   GH E ++TL E   +++ RD KG T L LA   G    VE+L  +GA    + 
Sbjct: 1087 LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 1146

Query: 649  RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMD----------------------- 685
             + K TPL  A + G  + + LL+  G   +  +V D                       
Sbjct: 1147 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1206

Query: 686  ---------AYGQTPLMLAIMNGHVDCVHLLLEKGSTADA-ADLRGRTALHRGAVTGCED 735
                       G +PLMLA MNGH   V LLL+ GS  +A  +    TAL      G  +
Sbjct: 1207 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 1266

Query: 736  CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQ--AALSTDPLDAGVDYSGYS 793
             ++ LLD  A V  R   G TP+  A++ G+  V R LL   A ++  P+ +  D    +
Sbjct: 1267 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD----T 1322

Query: 794  PMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNS 853
             +  A+  GH    ELL+                                   GA I + 
Sbjct: 1323 ALTIAADKGHYKFCELLI---------------------------------GRGAHI-DV 1348

Query: 854  RDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLL 911
            R+ KG TPL  AA   ++  +++L+Q  A+V+A D+   T LM A   G    V +L+
Sbjct: 1349 RNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406



 Score =  105 bits (261), Expect = 3e-22
 Identities = 120/418 (28%), Positives = 172/418 (41%), Gaps = 36/418 (8%)

Query: 605  AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS-G 663
            AE+  N    D++   +L  A   G    V  L   G S  + E   +   L   A S G
Sbjct: 224  AESTANAGQSDNR---SLAEACSEGDVNAVRKLLIEGRS--VNEHTEEGESLLCLACSAG 278

Query: 664  HTDSLHLLI-------DSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADA 716
            + +   +L+       D G + DIT         PLM A   GHV  V LLL   +  +A
Sbjct: 279  YYELAQVLLAMHANVEDRGIKGDIT---------PLMAAANGGHVKIVKLLLAHKADVNA 329

Query: 717  ADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQA 776
                G TAL      G  D +  LL+  A +   +  G TP+  A + GH  V R LL+ 
Sbjct: 330  QSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLEN 389

Query: 777  ALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCAVINNQ 835
                  ++   +    S +  A Y GH + +  LLE  +   +      T L  A ++  
Sbjct: 390  GAG---INTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH 446

Query: 836  DSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL 895
                 +LL + GA+ VN       +PL  AA   +V    +L++  A +   +  G T L
Sbjct: 447  VEVARLLLDS-GAQ-VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPL 504

Query: 896  MTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLIN 955
            M AA  G    V  LL +G       +E + TAL LAC  G  + A  ++    D+ L  
Sbjct: 505  MEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC 564

Query: 956  ATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPN--KDVADCL 1011
            +T      PL  AA+ G   +V+ LL+ GA V A    G T       N   DVAD L
Sbjct: 565  ST------PLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVL 616



 Score =  104 bits (259), Expect = 5e-22
 Identities = 90/275 (32%), Positives = 134/275 (48%), Gaps = 6/275 (2%)

Query: 11   PLVQAIFSRDVEEVRSLLSQKENINVLDQERR-TPLHAAAYVGDVPILQLLLMSGANVNA 69
            PL+ A  +  V  V  LL    +I    +  + TPL  A   G   +++LLL  GAN   
Sbjct: 1119 PLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEH 1178

Query: 70   KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNAR--DKLWQTPLHVAAANRATKCAEALA 127
            ++    TPL  AA+     ++ +LL   A++N+R   KL  +PL +AA N  T   + L 
Sbjct: 1179 RNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLL 1238

Query: 128  PLLSSLNVADRSGR-SALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHL 186
             + S +N    + R +AL  A   G  E V+LLL++ A++    K    PL  AA  G+ 
Sbjct: 1239 DMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1298

Query: 187  EVLKLLVARGADLGCK--DRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALH 244
            EV ++L+ +GAD+            L  AA  G  +  + L+  GA ID  N  GNT L 
Sbjct: 1299 EVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLW 1358

Query: 245  IACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVA 279
            +A   G   V   LV AGA+V+  +++  TPL  A
Sbjct: 1359 LAANGGHLDVVQLLVQAGADVDAADNRKITPLMAA 1393



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 87/273 (31%), Positives = 134/273 (49%), Gaps = 15/273 (5%)

Query: 7    TDQPPLVQAIFSRDVEEVRSLLSQ---KENINVLDQERRTPLHAAAYVGDVPILQLLLMS 63
            T   PL  A      E V  LL++   KE+ NV D    TPL  AA  G V I+++LL +
Sbjct: 1149 TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY---TPLSLAASGGYVNIIKILLNA 1205

Query: 64   GANVNAK--DTLWLTPLHRAAASRNEKVLGLLLAHSADVNAR-DKLWQTPLHVAAANRAT 120
            GA +N++    L ++PL  AA + +   + LLL   +D+NA+ +    T L +A     T
Sbjct: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1265

Query: 121  KCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV--CDKKERQPLH 178
            +    L    +++    ++G + L  A   G+ E   +LL+KGA +N           L 
Sbjct: 1266 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1325

Query: 179  WAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAF 238
             AA  GH +  +LL+ RGA +  +++KG   L  AA  G ++VV+ L++ GA++D  +  
Sbjct: 1326 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1385

Query: 239  GNTALHIACYLGQDAVAIELVNAGANVNQ-PND 270
              T L  A   G   V   LV     VNQ P+D
Sbjct: 1386 KITPLMAAFRKGHVKVVRYLVK---EVNQFPSD 1415



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 74/228 (32%), Positives = 113/228 (49%), Gaps = 5/228 (2%)

Query: 5    SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERR--TPLHAAAYVGDVPILQLLLM 62
            +++D  PL  A     V  ++ LL+    IN     +   +PL  AA  G    ++LLL 
Sbjct: 1180 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD 1239

Query: 63   SGANVNAK-DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATK 121
             G+++NA+ +T   T L  A      +V+ LLL   A+V  R K   TPL  AA+    +
Sbjct: 1240 MGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1299

Query: 122  CAEALAPLLSSLNV--ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHW 179
                L    + +N      S  +AL  A   GH +   LL+ +GA ++V +KK   PL  
Sbjct: 1300 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWL 1359

Query: 180  AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227
            AA  GHL+V++LLV  GAD+   D +    L  A   G ++VV+YL++
Sbjct: 1360 AANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 76/286 (26%), Positives = 126/286 (44%), Gaps = 32/286 (11%)

Query: 12  LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD 71
           L++A     VE  R LL     +N+      +PL  AA  G V +  LL+  GA++   +
Sbjct: 438 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN 497

Query: 72  TLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQ----------------------- 108
               TPL  AA   +E+++ LLL   A++NA+ +  Q                       
Sbjct: 498 DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAG 557

Query: 109 --------TPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLL 160
                   TPL  AA     +  + L    ++++    +G +AL +A  +GH +  ++LL
Sbjct: 558 ADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL 617

Query: 161 NKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLG-CKDRKGYGLLHTAAASGQI 219
             GA L    +  R PL  AA  GH+  ++ L+++GA++        + +L  A A G +
Sbjct: 618 QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL 677

Query: 220 EVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANV 265
            VV+ LL  GA+       G+T L  A   G  +V   L++   N+
Sbjct: 678 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNL 723



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 58/177 (32%), Positives = 83/177 (46%), Gaps = 4/177 (2%)

Query: 851  VNSRDAKGR-TPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 909
            V  R  KG  TPL AAA   +V  +++LL H+A+VNA   TG TAL  A   G    V+ 
Sbjct: 293  VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKV 352

Query: 910  LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969
            LL  G A +   +EN +T L  A S GH + A ++L      G+   +N   +  L +A 
Sbjct: 353  LLESG-ASIEDHNENGHTPLMEAGSAGHVEVARLLLEN--GAGINTHSNEFKESALTLAC 409

Query: 970  RNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFPPKDA 1026
              G   +V+ LL  GA      +E HT  +    +  V     L+ S  +   P D+
Sbjct: 410  YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  169 bits (427), Expect = 2e-41
 Identities = 163/602 (27%), Positives = 258/602 (42%), Gaps = 98/602 (16%)

Query: 8   DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67
           D   L +A    DV  VR LL +  ++N   +E  + L  A   G   + Q+LL   ANV
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264

Query: 68  NAKDTLW-LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126
             +     +TPL  A++     ++ LLL H ADVN++     T L  A A       + L
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324

Query: 127 APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP-LHWAAFLGH 185
               +++   + +G + L  A  +GH+E   +LL+ GA +N    + ++  L  A + GH
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384

Query: 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245
           L++++ L+  GAD   K  + +  L  A   G +EV + LL  GA+++ P     + L +
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 444

Query: 246 ACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKE 305
           A   G   +A  L+  GAN+ + ND+G+TPL  AA   +  + + LL+  GA++N Q++E
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEE 503

Query: 306 GKSPLHMAAIHGRFTR-SQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD 364
            +      A  G F+  +  LI+ G++I+      +TPL  A++ GH  L+  L+ +GA 
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELG---CSTPLMEASQEGHLELVKYLLASGA- 559

Query: 365 TARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGR 424
                                                    N H  +A          G 
Sbjct: 560 -----------------------------------------NVHATTA---------TGD 569

Query: 425 TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE 484
           T L  A   G+ +  ++LL +GADL    + GRTPL  AA  G       L++ GA VN 
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629

Query: 485 ADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544
                      A A++ +          H A                 +E LL +GADP+
Sbjct: 630 -----------ATANNDHTVVSLACAGGHLA----------------VVELLLAHGADPT 662

Query: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLE----DV---------ESTIPVSPLHL 591
            R + G T +  AA  G+   +  LL+   N L     DV         +S +P  P H 
Sbjct: 663 HRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPTHT 722

Query: 592 AA 593
            A
Sbjct: 723 LA 724



 Score =  143 bits (360), Expect = 1e-33
 Identities = 162/634 (25%), Positives = 249/634 (39%), Gaps = 106/634 (16%)

Query: 187 EVLKLLVARGADLGCKDRKGYGLLHT---AAASGQIEVVKYLLRMGAEIDEPNAFGNTAL 243
           E+     A GADL   D +    L     AA  G++         G    +P        
Sbjct: 123 EIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTAD-----GKAFADPEVLRRLTS 177

Query: 244 HIACYLGQDAVAIELVNA--GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY 301
            ++C L + A A+  + A    N  Q + +        A S      +  L++ G  VN 
Sbjct: 178 SVSCALDEAAAALTRMKAENSHNAGQVDTRSLAE----ACSDGDVNAVRKLLDEGRSVNE 233

Query: 302 QSKEGKSPLHMAAIHGRFTRSQILIQNGSEI-DCADKFGNTPLHVAARYGHELLISTLMT 360
            ++EG+S L +A   G +  +Q+L+   + + D  +K   TPL  A+  G+  ++  L+ 
Sbjct: 234 HTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL- 292

Query: 361 NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPD 420
                    +HD                                          D+N+  
Sbjct: 293 ---------LHDA-----------------------------------------DVNSQS 302

Query: 421 NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480
             G T L  A +GG V+ + +LL+ GA++   ++ G TPL  AA+ G  + A  L+  GA
Sbjct: 303 ATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362

Query: 481 GVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAE-EDEPLKESRRKEAFFCLEFLLDN 539
           G+N                            +H  E ++  L  +  K     + FLL+ 
Sbjct: 363 GIN----------------------------THSNEFKESALTLACYKGHLDMVRFLLEA 394

Query: 540 GADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCE 599
           GAD   +  + +TA+  A   G+ +   LLL+         +S    SPL LAA  GH E
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF--ESPLTLAACGGHVE 452

Query: 600 ALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAA 659
               L E   NL+  + +G T L  A   G  E V +L A GA+   +  + + T L  A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 660 AASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADL 719
              G ++    LI +G  ADI    +    TPLM A   GH++ V  LL  G+   A   
Sbjct: 513 CCGGFSEVADFLIKAG--ADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTA 566

Query: 720 RGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALS 779
            G TAL      G  D    LL   A +      GRTP+  A+  GH   ++ L+    +
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGAN 626

Query: 780 TDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH 813
            +   A  D++  S    A   GH   +ELLL H
Sbjct: 627 VNRATANNDHTVVS---LACAGGHLAVVELLLAH 657



 Score =  135 bits (341), Expect = 2e-31
 Identities = 142/486 (29%), Positives = 217/486 (44%), Gaps = 27/486 (5%)

Query: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPN 269
           L  A + G +  V+ LL  G  ++E    G + L +AC  G   +A  L+   ANV    
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268

Query: 270 DKG-FTPLHVAAVSTNGAL-CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQ 327
           +KG  TPL   A S+ G L  ++LL+ + ADVN QS  G + L  A   G     ++L+ 
Sbjct: 269 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326

Query: 328 NGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD-TARRGIHDMFPLHLAVLFGFSD 386
            G+ I+  ++ G+TPL  AA  GH  +   L+ +GA             L LA   G  D
Sbjct: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386

Query: 387 CCRKLLSSG---------QLYSIVSSLSNEHV------LSAGFDINTPDNLGRTCLHAAA 431
             R LL +G            +++ +  + HV      L +G  +N P +   + L  AA
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 446

Query: 432 SGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVN-EADCKGC 490
            GG+VE   LL+  GA+L   +  G TPL  AA  G  +    L+  GA +N + +    
Sbjct: 447 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE 506

Query: 491 SPLHYAAASDTYRRAEPHTPSSHDAEE--DEPLKESRRKEAFFCLEFLLDNGADPSLRDR 548
           + L  A        A+    +  D E     PL E+ ++     +++LL +GA+      
Sbjct: 507 TALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTA 566

Query: 549 QGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETL 608
            G TA+ YA   G+    ++LL+   +   + ES    +PL  AA  GH   ++ L    
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADL--EHESEGGRTPLMKAARAGHLCTVQFLISKG 624

Query: 609 VNLD-VRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDS 667
            N++    +   T + LA   G    VE+L AHGA       K   T L  AA  GHT+ 
Sbjct: 625 ANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP-THRLKDGSTMLIEAAKGGHTNV 683

Query: 668 LHLLID 673
           +  L+D
Sbjct: 684 VSYLLD 689



 Score =  132 bits (331), Expect = 2e-30
 Identities = 144/531 (27%), Positives = 227/531 (42%), Gaps = 49/531 (9%)

Query: 493 LHYAAASDTYRRAEPHTPSSHDAEEDEP--LKESRRKEAFFCLEFLLDNGADPSLRDRQG 550
           L  AAA+ T  +AE    +SH+A + +   L E+        +  LLD G   +    +G
Sbjct: 183 LDEAAAALTRMKAE----NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG 238

Query: 551 YTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVN 610
            + +  A + G  +  ++LL M  N +ED  +   ++PL  A+  G+ + +K L     +
Sbjct: 239 ESLLCLACSAGYYELAQVLLAMHAN-VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 297

Query: 611 LDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHL 670
           ++ +   G TAL  A   G  + V+VL   GA+ +    +   TPL  AA++GH +   +
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGAN-IEDHNENGHTPLMEAASAGHVEVARV 356

Query: 671 LIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAV 730
           L+D G  A I    + + ++ L LA   GH+D V  LLE G+  +       TAL    +
Sbjct: 357 LLDHG--AGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414

Query: 731 TGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYS 790
            G  +    LLD  A V        +P+ LA+  GH  +   L++   + +     V+  
Sbjct: 415 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE----VNDE 470

Query: 791 GYSPMHWASYTGHEDCLELLLEHSPF--SYLEGNPFTPLHCAVINNQDSTTEMLLGALGA 848
           GY+P+  A+  GHE+ + LLL       +  E    T L  A         + L+ A GA
Sbjct: 471 GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA-GA 529

Query: 849 KI-----------------------------VNSRDAKGRTPLHAAAFADNVSGLRMLLQ 879
            I                             V++  A G T L  A    +     +LLQ
Sbjct: 530 DIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589

Query: 880 HQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEK 939
             A++      GRT LM AA  G    V+FL+ +G         N +T + LAC+ GH  
Sbjct: 590 AGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLA 649

Query: 940 CALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAV 990
              ++LA   D        S +   L  AA+ G  +VV  LL +   VL+V
Sbjct: 650 VVELLLAHGADPTHRLKDGSTM---LIEAAKGGHTNVVSYLLDYPNNVLSV 697



 Score =  122 bits (307), Expect = 1e-27
 Identities = 100/324 (30%), Positives = 158/324 (48%), Gaps = 42/324 (12%)

Query: 76   TPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNV 135
            T L  A A  +E+++ +L+A  A +  RDK   TPL +AA        E L      +  
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 136  -ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVA 194
             ++R+  + L  A   G  E V+LLL +GA+    +  +  PL  AA  G++ ++K+L+ 
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176

Query: 195  RGADLGCKDRKGYGL--LHTAAASGQIEVVKYLLRMGAEID---EPNAFGNTALHIACYL 249
             GA++  +     G+  L  AA +G +  VK LL MG++I+   E N   NTAL +AC+ 
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR--NTALTLACFQ 1234

Query: 250  GQDAVAIELVNAGANVNQPNDKGFTPLHVAAV------------------------STNG 285
            G+  V   L++  ANV      G TPL  AA                         S + 
Sbjct: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1294

Query: 286  ALCL----------ELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCA 335
            AL +          ELL++ GA ++ ++K+G +PL +A+  G F   Q+L+Q G+++D A
Sbjct: 1295 ALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAA 1354

Query: 336  DKFGNTPLHVAARYGHELLISTLM 359
            D    TPL  A R GH  ++  L+
Sbjct: 1355 DNRKITPLMSAFRKGHVKVVQYLV 1378



 Score =  105 bits (262), Expect = 2e-22
 Identities = 116/423 (27%), Positives = 172/423 (40%), Gaps = 50/423 (11%)

Query: 592  AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651
            A  +G   A++ L +   +++    +G + L LA   G  E  +VL A            
Sbjct: 212  ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA------------ 259

Query: 652  KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711
                +HA              D G + DIT         PLM A   G++D V LLL   
Sbjct: 260  ----MHANVE-----------DRGNKGDIT---------PLMAASSGGYLDIVKLLLLHD 295

Query: 712  STADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLR 771
            +  ++    G TAL      G  D +  LL+  A +   +  G TP+  A++ GH  V R
Sbjct: 296  ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355

Query: 772  TLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCA 830
             LL        ++   +    S +  A Y GH D +  LLE  +   +      T L  A
Sbjct: 356  VLLDHGAG---INTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEA 412

Query: 831  VINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT 890
             ++       +LL + GA+ VN       +PL  AA   +V    +L++  A +   +  
Sbjct: 413  CMDGHVEVARLLLDS-GAQ-VNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE 470

Query: 891  GRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQD 950
            G T LM AA  G    V  LL +G       +E + TAL LAC  G  + A  ++    D
Sbjct: 471  GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 530

Query: 951  LGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPN--KDVA 1008
            + L  +T      PL  A++ G   +V+ LL+ GA V A    G T       N   DVA
Sbjct: 531  IELGCST------PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 584

Query: 1009 DCL 1011
            D L
Sbjct: 585  DVL 587



 Score =  105 bits (262), Expect = 2e-22
 Identities = 107/386 (27%), Positives = 167/386 (43%), Gaps = 34/386 (8%)

Query: 393  SSGQLYSIVSSLSNEHVL-SAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRR 451
            S  Q  S V+S S   V  S   D +T  N   T L  A +GG+ E +++L++  A +  
Sbjct: 1025 SCSQTTSNVASQSMPPVYPSVDIDAHTESNHD-TALTLACAGGHEELVSVLIARDAKIEH 1083

Query: 452  RDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPS 511
            RDK G TPL  AA  G       L+  G  +                            +
Sbjct: 1084 RDKKGFTPLILAATAGHVGVVEILLDKGGDIE---------------------------A 1116

Query: 512  SHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLE 571
              +  +D PL  +        ++ LL  GA+   R+   YT +  AA+ G    +++LL 
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176

Query: 572  MSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGR-TALFLATERGS 630
                      S + +SPL LAA NGH  A+K L +   +++ +    R TAL LA  +G 
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236

Query: 631  TECVEVLTAHGASALIKER-KRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQ 689
             E V +L    A+  ++ R K   TPL  AA+ G+ +   +L+D G   +   V  +   
Sbjct: 1237 AEVVSLLLDRKAN--VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR-D 1293

Query: 690  TPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLC 749
            T L +A   GH     LL+ +G+  D  + +G T L   +  G  D +  L+   A V  
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353

Query: 750  RDFKGRTPIHLASACGHTAVLRTLLQ 775
             D +  TP+  A   GH  V++ L++
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  103 bits (257), Expect = 9e-22
 Identities = 103/371 (27%), Positives = 163/371 (43%), Gaps = 51/371 (13%)

Query: 240  NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299
            +TAL +AC  G + +   L+   A +   + KGFTPL +AA + +  + +E+L++ G D+
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV-VEILLDKGGDI 1114

Query: 300  NYQSKEGK-SPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
              QS+  K +PL +A   GR     +L+  G+  +  +    TPL +AA  G+  +I  L
Sbjct: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174

Query: 359  MTNGAD-TARRGIH-DMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDI 416
            +  GA+  +R G    + PL LA + G     + LL  G                   DI
Sbjct: 1175 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS------------------DI 1216

Query: 417  NTPDNLGR-TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTL 475
            N      R T L  A   G  E ++LLL   A++  R K G TPL  AA+ G  +    L
Sbjct: 1217 NAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1276

Query: 476  VTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEF 535
            +  GA VN                       P  PSS D        +   K   FC E 
Sbjct: 1277 LDKGADVN----------------------APPVPSSRDTALTIAADKGHYK---FC-EL 1310

Query: 536  LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYN 595
            L+  GA   +R+++G T +  A+  G+   ++LL++   +   D      ++PL  A   
Sbjct: 1311 LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV--DAADNRKITPLMSAFRK 1368

Query: 596  GHCEALKTLAE 606
            GH + ++ L +
Sbjct: 1369 GHVKVVQYLVK 1379



 Score =  101 bits (252), Expect = 3e-21
 Identities = 88/272 (32%), Positives = 132/272 (48%), Gaps = 6/272 (2%)

Query: 11   PLVQAIFSRDVEEVRSLLSQKENINVLDQERR-TPLHAAAYVGDVPILQLLLMSGANVNA 69
            PL+ A  +  V  V  LL +  +I    +  + TPL  A   G   ++ LLL  GAN   
Sbjct: 1091 PLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEH 1150

Query: 70   KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNAR--DKLWQTPLHVAAANRATKCAEALA 127
            ++    TPL  AA+     ++ +LL   A++N+R   KL  +PL +AA N      + L 
Sbjct: 1151 RNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210

Query: 128  PLLSSLNVADRSGR-SALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHL 186
             + S +N    + R +AL  A   G  E V+LLL++ A++    K    PL  AA  G+ 
Sbjct: 1211 DMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1270

Query: 187  EVLKLLVARGADLGCK--DRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALH 244
            EV ++L+ +GAD+            L  AA  G  +  + L+  GA ID  N  GNT L 
Sbjct: 1271 EVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLW 1330

Query: 245  IACYLGQDAVAIELVNAGANVNQPNDKGFTPL 276
            +A   G   V   LV AGA+V+  +++  TPL
Sbjct: 1331 LASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362



 Score =  100 bits (248), Expect = 1e-20
 Identities = 100/358 (27%), Positives = 146/358 (40%), Gaps = 73/358 (20%)

Query: 589  LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
            L LA   GH E +  L      ++ RD KG T L LA   G    VE+L   G     + 
Sbjct: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS 1118

Query: 649  RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMD----------------------- 685
             + K TPL  A + G  + + LL+  G   +  +V D                       
Sbjct: 1119 ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1178

Query: 686  ---------AYGQTPLMLAIMNGHVDCVHLLLEKGSTADA-ADLRGRTALHRGAVTGCED 735
                       G +PLMLA MNGHV  V LLL+ GS  +A  +    TAL      G  +
Sbjct: 1179 AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAE 1238

Query: 736  CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQ--AALSTDPLDAGVDYSGYS 793
             ++ LLD  A V  R   G TP+  A++ G+  V R LL   A ++  P+ +  D    +
Sbjct: 1239 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD----T 1294

Query: 794  PMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNS 853
             +  A+  GH    ELL+                                   GA I + 
Sbjct: 1295 ALTIAADKGHYKFCELLIHR---------------------------------GAHI-DV 1320

Query: 854  RDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLL 911
            R+ KG TPL  A+   +   +++L+Q  A+V+A D+   T LM+A   G    V++L+
Sbjct: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 108/376 (28%), Positives = 157/376 (41%), Gaps = 56/376 (14%)

Query: 340  NTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYS 399
            +T L +A   GHE L+S L+   A    R      PL LA   G       LL  G    
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115

Query: 400  IVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTP 459
              S  + +                 T L  A SGG  E ++LLL+ GA+   R+    TP
Sbjct: 1116 AQSERTKD-----------------TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTP 1158

Query: 460  LHYAAANGSYQCAVTLVTAGAGVNEADCK--GCSPLHYAAASDTYRRAEPHTPSSHDAEE 517
            L  AA+ G       L+ AGA +N       G SPL  AA +        H P+      
Sbjct: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG-------HVPA------ 1205

Query: 518  DEPLKESRRKEAFFCLEFLLDNGADPSLR-DRQGYTAVHYAAAYGNRQNLELLLEMSFNC 576
                           ++ LLD G+D + + +    TA+  A   G  + + LLL+   N 
Sbjct: 1206 ---------------VKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANV 1250

Query: 577  LEDVESTIPVSPLHLAAYNGHCEALKTLAE--TLVNLDVRDHKGRTALFLATERGSTECV 634
                ++ +  +PL  AA  G+ E  + L +    VN         TAL +A ++G  +  
Sbjct: 1251 EHRAKTGL--TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308

Query: 635  EVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLML 694
            E+L   GA   ++ +K   TPL  A+  GH D + LL+ +G  AD+ D  D    TPLM 
Sbjct: 1309 ELLIHRGAHIDVRNKKGN-TPLWLASNGGHFDVVQLLVQAG--ADV-DAADNRKITPLMS 1364

Query: 695  AIMNGHVDCVHLLLEK 710
            A   GHV  V  L+++
Sbjct: 1365 AFRKGHVKVVQYLVKE 1380



 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 74/228 (32%), Positives = 116/228 (50%), Gaps = 5/228 (2%)

Query: 5    SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERR--TPLHAAAYVGDVPILQLLLM 62
            +++D  PL  A     V  ++ LL+    IN     +   +PL  AA  G VP ++LLL 
Sbjct: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD 1211

Query: 63   SGANVNAK-DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATK 121
             G+++NA+ +T   T L  A      +V+ LLL   A+V  R K   TPL  AA+    +
Sbjct: 1212 MGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1271

Query: 122  CAEALAPLLSSLNV--ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHW 179
                L    + +N      S  +AL  A   GH +   LL+++GA ++V +KK   PL  
Sbjct: 1272 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWL 1331

Query: 180  AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227
            A+  GH +V++LLV  GAD+   D +    L +A   G ++VV+YL++
Sbjct: 1332 ASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 100/339 (29%), Positives = 149/339 (43%), Gaps = 49/339 (14%)

Query: 723  TALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDP 782
            TAL      G E+ ++ L+  DA +  RD KG TP+ LA+  GH  V+  LL        
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG---GD 1113

Query: 783  LDAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTTEM 841
            ++A  + +  +P+  A   G ++ ++LLL   +   +   + +TPL  A      +  ++
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173

Query: 842  LLGALGAKIVNSRDAK--GRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGR-TALMTA 898
            LL A GA+I NSR     G +PL  AA   +V  +++LL   +++NA   T R TAL  A
Sbjct: 1174 LLNA-GAEI-NSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231

Query: 899  AENGQTAAVEFLL-------YRGKADLTVLDE---------------------------N 924
               G+   V  LL       +R K  LT L E                           +
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291

Query: 925  KNTALHLACSKGHEK-CALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSH 983
            ++TAL +A  KGH K C L+I         I+  N     PL +A+  G   VVQ L+  
Sbjct: 1292 RDTALTIAADKGHYKFCELLIHRGAH----IDVRNKKGNTPLWLASNGGHFDVVQLLVQA 1347

Query: 984  GATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFP 1022
            GA V A D    TP L  A  K     +  ++  +  FP
Sbjct: 1348 GADVDAADNRKITP-LMSAFRKGHVKVVQYLVKEVNQFP 1385



 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 85/273 (31%), Positives = 132/273 (48%), Gaps = 15/273 (5%)

Query: 7    TDQPPLVQAIFSRDVEEVRSLLSQ---KENINVLDQERRTPLHAAAYVGDVPILQLLLMS 63
            T   PL  A      E V  LL++   KE+ NV D    TPL  AA  G V I+++LL +
Sbjct: 1121 TKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY---TPLSLAASGGYVNIIKILLNA 1177

Query: 64   GANVNAK--DTLWLTPLHRAAASRNEKVLGLLLAHSADVNAR-DKLWQTPLHVAAANRAT 120
            GA +N++    L ++PL  AA + +   + LLL   +D+NA+ +    T L +A      
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237

Query: 121  KCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV--CDKKERQPLH 178
            +    L    +++    ++G + L  A   G+ E   +LL+KGA +N           L 
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297

Query: 179  WAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAF 238
             AA  GH +  +LL+ RGA +  +++KG   L  A+  G  +VV+ L++ GA++D  +  
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357

Query: 239  GNTALHIACYLGQDAVAIELVNAGANVNQ-PND 270
              T L  A   G   V   LV     VNQ P+D
Sbjct: 1358 KITPLMSAFRKGHVKVVQYLVK---EVNQFPSD 1387



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 77/291 (26%), Positives = 111/291 (38%), Gaps = 41/291 (14%)

Query: 760  LASAC--GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFS 817
            LA AC  G    +R LL    S +         G S +  A   G+ +  ++LL      
Sbjct: 209  LAEACSDGDVNAVRKLLDEGRSVNEHTE----EGESLLCLACSAGYYELAQVLLAMHANV 264

Query: 818  YLEGNP--FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLR 875
               GN    TPL  A         ++LL  L    VNS+ A G T L  A     V  ++
Sbjct: 265  EDRGNKGDITPLMAASSGGYLDIVKLLL--LHDADVNSQSATGNTALTYACAGGFVDIVK 322

Query: 876  MLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSK 935
            +LL   A +   +  G T LM AA  G       LL  G    T  +E K +AL LAC K
Sbjct: 323  VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382

Query: 936  GHEKCALMILAETQDL------------------------------GLINATNSALQMPL 965
            GH      +L    D                                 +N    + + PL
Sbjct: 383  GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 442

Query: 966  HIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILS 1016
             +AA  G   +   L+  GA +  V++EG+TP +  A  +   + +AL+L+
Sbjct: 443  TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA-REGHEEMVALLLA 492



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 55/177 (31%), Positives = 82/177 (46%), Gaps = 4/177 (2%)

Query: 851  VNSRDAKGR-TPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 909
            V  R  KG  TPL AA+    +  +++LL H A+VN+   TG TAL  A   G    V+ 
Sbjct: 264  VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323

Query: 910  LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969
            LL  G A++   +EN +T L  A S GH + A ++L      G+   +N   +  L +A 
Sbjct: 324  LLNEG-ANIEDHNENGHTPLMEAASAGHVEVARVLL--DHGAGINTHSNEFKESALTLAC 380

Query: 970  RNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFPPKDA 1026
              G   +V+ LL  GA      +E HT  +    +  V     L+ S  +   P D+
Sbjct: 381  YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437



 Score = 39.3 bits (90), Expect = 0.020
 Identities = 32/93 (34%), Positives = 47/93 (50%), Gaps = 6/93 (6%)

Query: 922  DENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALL 981
            + N +TAL LAC+ GHE+   +++A       I   +     PL +AA  G   VV+ LL
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARD---AKIEHRDKKGFTPLILAATAGHVGVVEILL 1108

Query: 982  SHGATVLAVDEE-GHTP-ALACAPNK-DVADCL 1011
              G  + A  E    TP +LAC+  + +V D L
Sbjct: 1109 DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLL 1141


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  169 bits (427), Expect = 2e-41
 Identities = 163/602 (27%), Positives = 258/602 (42%), Gaps = 98/602 (16%)

Query: 8   DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67
           D   L +A    DV  VR LL +  ++N   +E  + L  A   G   + Q+LL   ANV
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264

Query: 68  NAKDTLW-LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126
             +     +TPL  A++     ++ LLL H ADVN++     T L  A A       + L
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324

Query: 127 APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP-LHWAAFLGH 185
               +++   + +G + L  A  +GH+E   +LL+ GA +N    + ++  L  A + GH
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384

Query: 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245
           L++++ L+  GAD   K  + +  L  A   G +EV + LL  GA+++ P     + L +
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 444

Query: 246 ACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKE 305
           A   G   +A  L+  GAN+ + ND+G+TPL  AA   +  + + LL+  GA++N Q++E
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEE 503

Query: 306 GKSPLHMAAIHGRFTR-SQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD 364
            +      A  G F+  +  LI+ G++I+      +TPL  A++ GH  L+  L+ +GA 
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELG---CSTPLMEASQEGHLELVKYLLASGA- 559

Query: 365 TARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGR 424
                                                    N H  +A          G 
Sbjct: 560 -----------------------------------------NVHATTA---------TGD 569

Query: 425 TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE 484
           T L  A   G+ +  ++LL +GADL    + GRTPL  AA  G       L++ GA VN 
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629

Query: 485 ADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544
                      A A++ +          H A                 +E LL +GADP+
Sbjct: 630 -----------ATANNDHTVVSLACAGGHLA----------------VVELLLAHGADPT 662

Query: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLE----DV---------ESTIPVSPLHL 591
            R + G T +  AA  G+   +  LL+   N L     DV         +S +P  P H 
Sbjct: 663 HRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPTHT 722

Query: 592 AA 593
            A
Sbjct: 723 LA 724



 Score =  143 bits (360), Expect = 1e-33
 Identities = 162/634 (25%), Positives = 249/634 (39%), Gaps = 106/634 (16%)

Query: 187 EVLKLLVARGADLGCKDRKGYGLLHT---AAASGQIEVVKYLLRMGAEIDEPNAFGNTAL 243
           E+     A GADL   D +    L     AA  G++         G    +P        
Sbjct: 123 EIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTAD-----GKAFADPEVLRRLTS 177

Query: 244 HIACYLGQDAVAIELVNA--GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY 301
            ++C L + A A+  + A    N  Q + +        A S      +  L++ G  VN 
Sbjct: 178 SVSCALDEAAAALTRMKAENSHNAGQVDTRSLAE----ACSDGDVNAVRKLLDEGRSVNE 233

Query: 302 QSKEGKSPLHMAAIHGRFTRSQILIQNGSEI-DCADKFGNTPLHVAARYGHELLISTLMT 360
            ++EG+S L +A   G +  +Q+L+   + + D  +K   TPL  A+  G+  ++  L+ 
Sbjct: 234 HTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL- 292

Query: 361 NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPD 420
                    +HD                                          D+N+  
Sbjct: 293 ---------LHDA-----------------------------------------DVNSQS 302

Query: 421 NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480
             G T L  A +GG V+ + +LL+ GA++   ++ G TPL  AA+ G  + A  L+  GA
Sbjct: 303 ATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362

Query: 481 GVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAE-EDEPLKESRRKEAFFCLEFLLDN 539
           G+N                            +H  E ++  L  +  K     + FLL+ 
Sbjct: 363 GIN----------------------------THSNEFKESALTLACYKGHLDMVRFLLEA 394

Query: 540 GADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCE 599
           GAD   +  + +TA+  A   G+ +   LLL+         +S    SPL LAA  GH E
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF--ESPLTLAACGGHVE 452

Query: 600 ALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAA 659
               L E   NL+  + +G T L  A   G  E V +L A GA+   +  + + T L  A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 660 AASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADL 719
              G ++    LI +G  ADI    +    TPLM A   GH++ V  LL  G+   A   
Sbjct: 513 CCGGFSEVADFLIKAG--ADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTA 566

Query: 720 RGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALS 779
            G TAL      G  D    LL   A +      GRTP+  A+  GH   ++ L+    +
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGAN 626

Query: 780 TDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH 813
            +   A  D++  S    A   GH   +ELLL H
Sbjct: 627 VNRATANNDHTVVS---LACAGGHLAVVELLLAH 657



 Score =  135 bits (341), Expect = 2e-31
 Identities = 142/486 (29%), Positives = 217/486 (44%), Gaps = 27/486 (5%)

Query: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPN 269
           L  A + G +  V+ LL  G  ++E    G + L +AC  G   +A  L+   ANV    
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268

Query: 270 DKG-FTPLHVAAVSTNGAL-CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQ 327
           +KG  TPL   A S+ G L  ++LL+ + ADVN QS  G + L  A   G     ++L+ 
Sbjct: 269 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326

Query: 328 NGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD-TARRGIHDMFPLHLAVLFGFSD 386
            G+ I+  ++ G+TPL  AA  GH  +   L+ +GA             L LA   G  D
Sbjct: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386

Query: 387 CCRKLLSSG---------QLYSIVSSLSNEHV------LSAGFDINTPDNLGRTCLHAAA 431
             R LL +G            +++ +  + HV      L +G  +N P +   + L  AA
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 446

Query: 432 SGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVN-EADCKGC 490
            GG+VE   LL+  GA+L   +  G TPL  AA  G  +    L+  GA +N + +    
Sbjct: 447 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE 506

Query: 491 SPLHYAAASDTYRRAEPHTPSSHDAEE--DEPLKESRRKEAFFCLEFLLDNGADPSLRDR 548
           + L  A        A+    +  D E     PL E+ ++     +++LL +GA+      
Sbjct: 507 TALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTA 566

Query: 549 QGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETL 608
            G TA+ YA   G+    ++LL+   +   + ES    +PL  AA  GH   ++ L    
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADL--EHESEGGRTPLMKAARAGHLCTVQFLISKG 624

Query: 609 VNLD-VRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDS 667
            N++    +   T + LA   G    VE+L AHGA       K   T L  AA  GHT+ 
Sbjct: 625 ANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP-THRLKDGSTMLIEAAKGGHTNV 683

Query: 668 LHLLID 673
           +  L+D
Sbjct: 684 VSYLLD 689



 Score =  132 bits (331), Expect = 2e-30
 Identities = 144/531 (27%), Positives = 227/531 (42%), Gaps = 49/531 (9%)

Query: 493 LHYAAASDTYRRAEPHTPSSHDAEEDEP--LKESRRKEAFFCLEFLLDNGADPSLRDRQG 550
           L  AAA+ T  +AE    +SH+A + +   L E+        +  LLD G   +    +G
Sbjct: 183 LDEAAAALTRMKAE----NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG 238

Query: 551 YTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVN 610
            + +  A + G  +  ++LL M  N +ED  +   ++PL  A+  G+ + +K L     +
Sbjct: 239 ESLLCLACSAGYYELAQVLLAMHAN-VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 297

Query: 611 LDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHL 670
           ++ +   G TAL  A   G  + V+VL   GA+ +    +   TPL  AA++GH +   +
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGAN-IEDHNENGHTPLMEAASAGHVEVARV 356

Query: 671 LIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAV 730
           L+D G  A I    + + ++ L LA   GH+D V  LLE G+  +       TAL    +
Sbjct: 357 LLDHG--AGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414

Query: 731 TGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYS 790
            G  +    LLD  A V        +P+ LA+  GH  +   L++   + +     V+  
Sbjct: 415 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE----VNDE 470

Query: 791 GYSPMHWASYTGHEDCLELLLEHSPF--SYLEGNPFTPLHCAVINNQDSTTEMLLGALGA 848
           GY+P+  A+  GHE+ + LLL       +  E    T L  A         + L+ A GA
Sbjct: 471 GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA-GA 529

Query: 849 KI-----------------------------VNSRDAKGRTPLHAAAFADNVSGLRMLLQ 879
            I                             V++  A G T L  A    +     +LLQ
Sbjct: 530 DIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589

Query: 880 HQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEK 939
             A++      GRT LM AA  G    V+FL+ +G         N +T + LAC+ GH  
Sbjct: 590 AGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLA 649

Query: 940 CALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAV 990
              ++LA   D        S +   L  AA+ G  +VV  LL +   VL+V
Sbjct: 650 VVELLLAHGADPTHRLKDGSTM---LIEAAKGGHTNVVSYLLDYPNNVLSV 697



 Score =  122 bits (307), Expect = 1e-27
 Identities = 100/324 (30%), Positives = 158/324 (48%), Gaps = 42/324 (12%)

Query: 76   TPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNV 135
            T L  A A  +E+++ +L+A  A +  RDK   TPL +AA        E L      +  
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 136  -ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVA 194
             ++R+  + L  A   G  E V+LLL +GA+    +  +  PL  AA  G++ ++K+L+ 
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176

Query: 195  RGADLGCKDRKGYGL--LHTAAASGQIEVVKYLLRMGAEID---EPNAFGNTALHIACYL 249
             GA++  +     G+  L  AA +G +  VK LL MG++I+   E N   NTAL +AC+ 
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR--NTALTLACFQ 1234

Query: 250  GQDAVAIELVNAGANVNQPNDKGFTPLHVAAV------------------------STNG 285
            G+  V   L++  ANV      G TPL  AA                         S + 
Sbjct: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1294

Query: 286  ALCL----------ELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCA 335
            AL +          ELL++ GA ++ ++K+G +PL +A+  G F   Q+L+Q G+++D A
Sbjct: 1295 ALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAA 1354

Query: 336  DKFGNTPLHVAARYGHELLISTLM 359
            D    TPL  A R GH  ++  L+
Sbjct: 1355 DNRKITPLMSAFRKGHVKVVQYLV 1378



 Score =  105 bits (262), Expect = 2e-22
 Identities = 116/423 (27%), Positives = 172/423 (40%), Gaps = 50/423 (11%)

Query: 592  AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651
            A  +G   A++ L +   +++    +G + L LA   G  E  +VL A            
Sbjct: 212  ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA------------ 259

Query: 652  KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711
                +HA              D G + DIT         PLM A   G++D V LLL   
Sbjct: 260  ----MHANVE-----------DRGNKGDIT---------PLMAASSGGYLDIVKLLLLHD 295

Query: 712  STADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLR 771
            +  ++    G TAL      G  D +  LL+  A +   +  G TP+  A++ GH  V R
Sbjct: 296  ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355

Query: 772  TLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCA 830
             LL        ++   +    S +  A Y GH D +  LLE  +   +      T L  A
Sbjct: 356  VLLDHGAG---INTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEA 412

Query: 831  VINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT 890
             ++       +LL + GA+ VN       +PL  AA   +V    +L++  A +   +  
Sbjct: 413  CMDGHVEVARLLLDS-GAQ-VNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE 470

Query: 891  GRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQD 950
            G T LM AA  G    V  LL +G       +E + TAL LAC  G  + A  ++    D
Sbjct: 471  GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 530

Query: 951  LGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPN--KDVA 1008
            + L  +T      PL  A++ G   +V+ LL+ GA V A    G T       N   DVA
Sbjct: 531  IELGCST------PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 584

Query: 1009 DCL 1011
            D L
Sbjct: 585  DVL 587



 Score =  105 bits (262), Expect = 2e-22
 Identities = 107/386 (27%), Positives = 167/386 (43%), Gaps = 34/386 (8%)

Query: 393  SSGQLYSIVSSLSNEHVL-SAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRR 451
            S  Q  S V+S S   V  S   D +T  N   T L  A +GG+ E +++L++  A +  
Sbjct: 1025 SCSQTTSNVASQSMPPVYPSVDIDAHTESNHD-TALTLACAGGHEELVSVLIARDAKIEH 1083

Query: 452  RDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPS 511
            RDK G TPL  AA  G       L+  G  +                            +
Sbjct: 1084 RDKKGFTPLILAATAGHVGVVEILLDKGGDIE---------------------------A 1116

Query: 512  SHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLE 571
              +  +D PL  +        ++ LL  GA+   R+   YT +  AA+ G    +++LL 
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176

Query: 572  MSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGR-TALFLATERGS 630
                      S + +SPL LAA NGH  A+K L +   +++ +    R TAL LA  +G 
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236

Query: 631  TECVEVLTAHGASALIKER-KRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQ 689
             E V +L    A+  ++ R K   TPL  AA+ G+ +   +L+D G   +   V  +   
Sbjct: 1237 AEVVSLLLDRKAN--VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR-D 1293

Query: 690  TPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLC 749
            T L +A   GH     LL+ +G+  D  + +G T L   +  G  D +  L+   A V  
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353

Query: 750  RDFKGRTPIHLASACGHTAVLRTLLQ 775
             D +  TP+  A   GH  V++ L++
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  103 bits (257), Expect = 9e-22
 Identities = 103/371 (27%), Positives = 163/371 (43%), Gaps = 51/371 (13%)

Query: 240  NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299
            +TAL +AC  G + +   L+   A +   + KGFTPL +AA + +  + +E+L++ G D+
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV-VEILLDKGGDI 1114

Query: 300  NYQSKEGK-SPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
              QS+  K +PL +A   GR     +L+  G+  +  +    TPL +AA  G+  +I  L
Sbjct: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174

Query: 359  MTNGAD-TARRGIH-DMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDI 416
            +  GA+  +R G    + PL LA + G     + LL  G                   DI
Sbjct: 1175 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS------------------DI 1216

Query: 417  NTPDNLGR-TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTL 475
            N      R T L  A   G  E ++LLL   A++  R K G TPL  AA+ G  +    L
Sbjct: 1217 NAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1276

Query: 476  VTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEF 535
            +  GA VN                       P  PSS D        +   K   FC E 
Sbjct: 1277 LDKGADVN----------------------APPVPSSRDTALTIAADKGHYK---FC-EL 1310

Query: 536  LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYN 595
            L+  GA   +R+++G T +  A+  G+   ++LL++   +   D      ++PL  A   
Sbjct: 1311 LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV--DAADNRKITPLMSAFRK 1368

Query: 596  GHCEALKTLAE 606
            GH + ++ L +
Sbjct: 1369 GHVKVVQYLVK 1379



 Score =  101 bits (252), Expect = 3e-21
 Identities = 88/272 (32%), Positives = 132/272 (48%), Gaps = 6/272 (2%)

Query: 11   PLVQAIFSRDVEEVRSLLSQKENINVLDQERR-TPLHAAAYVGDVPILQLLLMSGANVNA 69
            PL+ A  +  V  V  LL +  +I    +  + TPL  A   G   ++ LLL  GAN   
Sbjct: 1091 PLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEH 1150

Query: 70   KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNAR--DKLWQTPLHVAAANRATKCAEALA 127
            ++    TPL  AA+     ++ +LL   A++N+R   KL  +PL +AA N      + L 
Sbjct: 1151 RNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210

Query: 128  PLLSSLNVADRSGR-SALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHL 186
             + S +N    + R +AL  A   G  E V+LLL++ A++    K    PL  AA  G+ 
Sbjct: 1211 DMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1270

Query: 187  EVLKLLVARGADLGCK--DRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALH 244
            EV ++L+ +GAD+            L  AA  G  +  + L+  GA ID  N  GNT L 
Sbjct: 1271 EVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLW 1330

Query: 245  IACYLGQDAVAIELVNAGANVNQPNDKGFTPL 276
            +A   G   V   LV AGA+V+  +++  TPL
Sbjct: 1331 LASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362



 Score =  100 bits (248), Expect = 1e-20
 Identities = 100/358 (27%), Positives = 146/358 (40%), Gaps = 73/358 (20%)

Query: 589  LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
            L LA   GH E +  L      ++ RD KG T L LA   G    VE+L   G     + 
Sbjct: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS 1118

Query: 649  RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMD----------------------- 685
             + K TPL  A + G  + + LL+  G   +  +V D                       
Sbjct: 1119 ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1178

Query: 686  ---------AYGQTPLMLAIMNGHVDCVHLLLEKGSTADA-ADLRGRTALHRGAVTGCED 735
                       G +PLMLA MNGHV  V LLL+ GS  +A  +    TAL      G  +
Sbjct: 1179 AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAE 1238

Query: 736  CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQ--AALSTDPLDAGVDYSGYS 793
             ++ LLD  A V  R   G TP+  A++ G+  V R LL   A ++  P+ +  D    +
Sbjct: 1239 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD----T 1294

Query: 794  PMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNS 853
             +  A+  GH    ELL+                                   GA I + 
Sbjct: 1295 ALTIAADKGHYKFCELLIHR---------------------------------GAHI-DV 1320

Query: 854  RDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLL 911
            R+ KG TPL  A+   +   +++L+Q  A+V+A D+   T LM+A   G    V++L+
Sbjct: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 108/376 (28%), Positives = 157/376 (41%), Gaps = 56/376 (14%)

Query: 340  NTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYS 399
            +T L +A   GHE L+S L+   A    R      PL LA   G       LL  G    
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115

Query: 400  IVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTP 459
              S  + +                 T L  A SGG  E ++LLL+ GA+   R+    TP
Sbjct: 1116 AQSERTKD-----------------TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTP 1158

Query: 460  LHYAAANGSYQCAVTLVTAGAGVNEADCK--GCSPLHYAAASDTYRRAEPHTPSSHDAEE 517
            L  AA+ G       L+ AGA +N       G SPL  AA +        H P+      
Sbjct: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG-------HVPA------ 1205

Query: 518  DEPLKESRRKEAFFCLEFLLDNGADPSLR-DRQGYTAVHYAAAYGNRQNLELLLEMSFNC 576
                           ++ LLD G+D + + +    TA+  A   G  + + LLL+   N 
Sbjct: 1206 ---------------VKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANV 1250

Query: 577  LEDVESTIPVSPLHLAAYNGHCEALKTLAE--TLVNLDVRDHKGRTALFLATERGSTECV 634
                ++ +  +PL  AA  G+ E  + L +    VN         TAL +A ++G  +  
Sbjct: 1251 EHRAKTGL--TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308

Query: 635  EVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLML 694
            E+L   GA   ++ +K   TPL  A+  GH D + LL+ +G  AD+ D  D    TPLM 
Sbjct: 1309 ELLIHRGAHIDVRNKKGN-TPLWLASNGGHFDVVQLLVQAG--ADV-DAADNRKITPLMS 1364

Query: 695  AIMNGHVDCVHLLLEK 710
            A   GHV  V  L+++
Sbjct: 1365 AFRKGHVKVVQYLVKE 1380



 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 74/228 (32%), Positives = 116/228 (50%), Gaps = 5/228 (2%)

Query: 5    SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERR--TPLHAAAYVGDVPILQLLLM 62
            +++D  PL  A     V  ++ LL+    IN     +   +PL  AA  G VP ++LLL 
Sbjct: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD 1211

Query: 63   SGANVNAK-DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATK 121
             G+++NA+ +T   T L  A      +V+ LLL   A+V  R K   TPL  AA+    +
Sbjct: 1212 MGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1271

Query: 122  CAEALAPLLSSLNV--ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHW 179
                L    + +N      S  +AL  A   GH +   LL+++GA ++V +KK   PL  
Sbjct: 1272 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWL 1331

Query: 180  AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227
            A+  GH +V++LLV  GAD+   D +    L +A   G ++VV+YL++
Sbjct: 1332 ASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 100/339 (29%), Positives = 149/339 (43%), Gaps = 49/339 (14%)

Query: 723  TALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDP 782
            TAL      G E+ ++ L+  DA +  RD KG TP+ LA+  GH  V+  LL        
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG---GD 1113

Query: 783  LDAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTTEM 841
            ++A  + +  +P+  A   G ++ ++LLL   +   +   + +TPL  A      +  ++
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173

Query: 842  LLGALGAKIVNSRDAK--GRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGR-TALMTA 898
            LL A GA+I NSR     G +PL  AA   +V  +++LL   +++NA   T R TAL  A
Sbjct: 1174 LLNA-GAEI-NSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231

Query: 899  AENGQTAAVEFLL-------YRGKADLTVLDE---------------------------N 924
               G+   V  LL       +R K  LT L E                           +
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291

Query: 925  KNTALHLACSKGHEK-CALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSH 983
            ++TAL +A  KGH K C L+I         I+  N     PL +A+  G   VVQ L+  
Sbjct: 1292 RDTALTIAADKGHYKFCELLIHRGAH----IDVRNKKGNTPLWLASNGGHFDVVQLLVQA 1347

Query: 984  GATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFP 1022
            GA V A D    TP L  A  K     +  ++  +  FP
Sbjct: 1348 GADVDAADNRKITP-LMSAFRKGHVKVVQYLVKEVNQFP 1385



 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 85/273 (31%), Positives = 132/273 (48%), Gaps = 15/273 (5%)

Query: 7    TDQPPLVQAIFSRDVEEVRSLLSQ---KENINVLDQERRTPLHAAAYVGDVPILQLLLMS 63
            T   PL  A      E V  LL++   KE+ NV D    TPL  AA  G V I+++LL +
Sbjct: 1121 TKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY---TPLSLAASGGYVNIIKILLNA 1177

Query: 64   GANVNAK--DTLWLTPLHRAAASRNEKVLGLLLAHSADVNAR-DKLWQTPLHVAAANRAT 120
            GA +N++    L ++PL  AA + +   + LLL   +D+NA+ +    T L +A      
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237

Query: 121  KCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV--CDKKERQPLH 178
            +    L    +++    ++G + L  A   G+ E   +LL+KGA +N           L 
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297

Query: 179  WAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAF 238
             AA  GH +  +LL+ RGA +  +++KG   L  A+  G  +VV+ L++ GA++D  +  
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357

Query: 239  GNTALHIACYLGQDAVAIELVNAGANVNQ-PND 270
              T L  A   G   V   LV     VNQ P+D
Sbjct: 1358 KITPLMSAFRKGHVKVVQYLVK---EVNQFPSD 1387



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 77/291 (26%), Positives = 111/291 (38%), Gaps = 41/291 (14%)

Query: 760  LASAC--GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFS 817
            LA AC  G    +R LL    S +         G S +  A   G+ +  ++LL      
Sbjct: 209  LAEACSDGDVNAVRKLLDEGRSVNEHTE----EGESLLCLACSAGYYELAQVLLAMHANV 264

Query: 818  YLEGNP--FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLR 875
               GN    TPL  A         ++LL  L    VNS+ A G T L  A     V  ++
Sbjct: 265  EDRGNKGDITPLMAASSGGYLDIVKLLL--LHDADVNSQSATGNTALTYACAGGFVDIVK 322

Query: 876  MLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSK 935
            +LL   A +   +  G T LM AA  G       LL  G    T  +E K +AL LAC K
Sbjct: 323  VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382

Query: 936  GHEKCALMILAETQDL------------------------------GLINATNSALQMPL 965
            GH      +L    D                                 +N    + + PL
Sbjct: 383  GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 442

Query: 966  HIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILS 1016
             +AA  G   +   L+  GA +  V++EG+TP +  A  +   + +AL+L+
Sbjct: 443  TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA-REGHEEMVALLLA 492



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 55/177 (31%), Positives = 82/177 (46%), Gaps = 4/177 (2%)

Query: 851  VNSRDAKGR-TPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 909
            V  R  KG  TPL AA+    +  +++LL H A+VN+   TG TAL  A   G    V+ 
Sbjct: 264  VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323

Query: 910  LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969
            LL  G A++   +EN +T L  A S GH + A ++L      G+   +N   +  L +A 
Sbjct: 324  LLNEG-ANIEDHNENGHTPLMEAASAGHVEVARVLL--DHGAGINTHSNEFKESALTLAC 380

Query: 970  RNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFPPKDA 1026
              G   +V+ LL  GA      +E HT  +    +  V     L+ S  +   P D+
Sbjct: 381  YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437



 Score = 39.3 bits (90), Expect = 0.020
 Identities = 32/93 (34%), Positives = 47/93 (50%), Gaps = 6/93 (6%)

Query: 922  DENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALL 981
            + N +TAL LAC+ GHE+   +++A       I   +     PL +AA  G   VV+ LL
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARD---AKIEHRDKKGFTPLILAATAGHVGVVEILL 1108

Query: 982  SHGATVLAVDEE-GHTP-ALACAPNK-DVADCL 1011
              G  + A  E    TP +LAC+  + +V D L
Sbjct: 1109 DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLL 1141


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  166 bits (419), Expect = 1e-40
 Identities = 116/354 (32%), Positives = 178/354 (50%), Gaps = 6/354 (1%)

Query: 12  LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD 71
           LV AI S D  ++  +L Q +++++      + LH A   G     + LL++ AN N  +
Sbjct: 410 LVDAIVSGDTSKLMKIL-QPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSN 468

Query: 72  TLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLS 131
               TPLH A   R   V+ LLLA    VNA+D+   T LH AA N        L    +
Sbjct: 469 RRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNA 528

Query: 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKL 191
           S+N  D  GR+ +H A   G    V +LL +G  +++  K    PLH+AA+ GHL ++KL
Sbjct: 529 SVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKL 588

Query: 192 LVAR-GADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250
           L  + G  +  +   G   LH AA  G   V + L+ + ++++  +    T LH+A   G
Sbjct: 589 LAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETG 648

Query: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALC-LELLVNNGADVNYQSKEGKSP 309
             + A  L++ GA        G+T LH+AA   NG L  ++LLV   ADV  +    ++ 
Sbjct: 649 HTSTARLLLHRGAGKEAMTSDGYTALHLAA--RNGHLATVKLLVEEKADVLARGPLNQTA 706

Query: 310 LHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGA 363
           LH+AA HG     + L+ +   ID  D+ G + LH+AA+  H   + TL+ +GA
Sbjct: 707 LHLAAAHGHSEVVEELV-SADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759



 Score =  146 bits (368), Expect = 1e-34
 Identities = 101/294 (34%), Positives = 147/294 (50%), Gaps = 3/294 (1%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           PL  A+  R    V  LL++K ++N  D+++ T LH AA  GD    +LLL   A+VN  
Sbjct: 474 PLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEV 533

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
           D    TP+H A     E ++ +LL    DV+ + K    PLH AA        + LA   
Sbjct: 534 DFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQP 593

Query: 131 S-SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL 189
             S+N     GR+ LH A   GH     +L++  + +NVC    + PLH AA  GH    
Sbjct: 594 GVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTA 653

Query: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYL 249
           +LL+ RGA        GY  LH AA +G +  VK L+   A++        TALH+A   
Sbjct: 654 RLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAH 713

Query: 250 GQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQS 303
           G   V  ELV+A   ++  +++G + LH+AA   + A  +E L+ +GA +N QS
Sbjct: 714 GHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRH-AQTVETLLRHGAHINLQS 765



 Score =  145 bits (365), Expect = 3e-34
 Identities = 113/387 (29%), Positives = 176/387 (45%), Gaps = 21/387 (5%)

Query: 97  SADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETV 156
           ++D+   D   +  +    +   +K  + L P    +++A  SG S LH AV +G  E  
Sbjct: 397 TSDLGTTDVQKKKLVDAIVSGDTSKLMKILQP--QDVDLALDSGASLLHLAVEAGQEECA 454

Query: 157 NLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAAS 216
             LL   A+ N+ +++   PLH A       V++LL+AR   +  KD   +  LH AA +
Sbjct: 455 KWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQN 514

Query: 217 GQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPL 276
           G     + LL   A ++E +  G T +H+AC  GQ+ +   L+  G +V+      + PL
Sbjct: 515 GDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPL 574

Query: 277 HVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCAD 336
           H AA   +  +   L    G  VN Q+ +G++PLH+AA  G +  ++ILI   S+++   
Sbjct: 575 HYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCS 634

Query: 337 KFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQ 396
               TPLHVAA  GH      L+  GA            LHLA   G     + L+    
Sbjct: 635 LLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVE--- 691

Query: 397 LYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFG 456
                       VL+ G        L +T LH AA+ G+ E +  L+S+   +   D+ G
Sbjct: 692 --------EKADVLARG-------PLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQG 735

Query: 457 RTPLHYAAANGSYQCAVTLVTAGAGVN 483
            + LH AA     Q   TL+  GA +N
Sbjct: 736 LSALHLAAQGRHAQTVETLLRHGAHIN 762



 Score =  129 bits (325), Expect = 1e-29
 Identities = 129/453 (28%), Positives = 190/453 (41%), Gaps = 68/453 (15%)

Query: 558 AAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHK 617
           +A+ +R +L L  E   +  +   + +    L  A  +G    L  + +   ++D+    
Sbjct: 379 SAFSSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQ-DVDLALDS 437

Query: 618 GRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGER 677
           G + L LA E G  EC + L  + A+  +  R+                           
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRR--------------------------- 470

Query: 678 ADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCL 737
                     G TPL +A+       V LLL +  + +A D    TALH  A  G E   
Sbjct: 471 ----------GSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESST 520

Query: 738 AALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYS-----GY 792
             LL+ +A V   DF+GRTP+H+A   G   ++R LL+          GVD S      +
Sbjct: 521 RLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR---------GVDVSLQGKDAW 571

Query: 793 SPMHWASYTGHEDCLELLLEHSPFSY----LEGNPFTPLHCAVINNQDSTTEMLLGALGA 848
            P+H+A++ GH   ++LL +    S     L+G   TPLH A          +L+     
Sbjct: 572 LPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR--TPLHLAAQRGHYRVARILIDLCSD 629

Query: 849 KIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVE 908
             VN      +TPLH AA   + S  R+LL   A   A    G TAL  AA NG  A V+
Sbjct: 630 --VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVK 687

Query: 909 FLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIA 968
            LL   KAD+        TALHLA + GH +    ++ E     +I+  +      LH+A
Sbjct: 688 -LLVEEKADVLARGPLNQTALHLAAAHGHSE----VVEELVSADVIDLFDEQGLSALHLA 742

Query: 969 ARNGLASVVQALLSHGATVLAVD---EEGHTPA 998
           A+   A  V+ LL HGA +       + GH PA
Sbjct: 743 AQGRHAQTVETLLRHGAHINLQSLKFQGGHGPA 775



 Score =  126 bits (317), Expect = 1e-28
 Identities = 126/453 (27%), Positives = 192/453 (42%), Gaps = 55/453 (12%)

Query: 390 KLLSSGQ------LYSIVSSLSNEHVLSAGF-------DINTPDNLGRTCLHAAASGGNV 436
           KL SSG       + S+ S+ S+   LS  F       D+ T D   +  + A  SG   
Sbjct: 361 KLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTS 420

Query: 437 ECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYA 496
           + + +L     DL      G + LH A   G  +CA  L+   A  N ++ +G +PL   
Sbjct: 421 KLMKILQPQDVDLALDS--GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL--- 475

Query: 497 AASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHY 556
                           H A E       RR      +E LL      + +D   +TA+H+
Sbjct: 476 ----------------HMAVE-------RRVRGV--VELLLARKISVNAKDEDQWTALHF 510

Query: 557 AAAYGNRQNLELLLEMSFNCLE-DVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRD 615
           AA  G+  +  LLLE + +  E D E     +P+H+A  +G    ++ L    V++ ++ 
Sbjct: 511 AAQNGDESSTRLLLEKNASVNEVDFEGR---TPMHVACQHGQENIVRILLRRGVDVSLQG 567

Query: 616 HKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSG 675
                 L  A  +G    V++L      ++  +     TPLH AA  GH     +LID  
Sbjct: 568 KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLC 627

Query: 676 ERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCED 735
              ++  ++    QTPL +A   GH     LLL +G+  +A    G TALH  A  G   
Sbjct: 628 SDVNVCSLL---AQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLA 684

Query: 736 CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPM 795
            +  L++  A VL R    +T +HLA+A GH+ V+  L    +S D +D   D  G S +
Sbjct: 685 TVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEEL----VSADVIDL-FDEQGLSAL 739

Query: 796 HWASYTGHEDCLELLLEHSPFSYLEGNPFTPLH 828
           H A+   H   +E LL H     L+   F   H
Sbjct: 740 HLAAQGRHAQTVETLLRHGAHINLQSLKFQGGH 772



 Score =  118 bits (295), Expect = 3e-26
 Identities = 101/359 (28%), Positives = 158/359 (44%), Gaps = 54/359 (15%)

Query: 532 CLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLL--EMSFNCLEDVESTIPVSPL 589
           C ++LL N A+P+L +R+G T +H A     R  +ELLL  ++S N  ++ + T     L
Sbjct: 453 CAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTA----L 508

Query: 590 HLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKER 649
           H AA NG   + + L E   +++  D +GRT + +A + G    V +L   G    + + 
Sbjct: 509 HFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSL-QG 567

Query: 650 KRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLE 709
           K  W PLH AA                                      GH+  V LL +
Sbjct: 568 KDAWLPLHYAA------------------------------------WQGHLPIVKLLAK 591

Query: 710 K-GSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTA 768
           + G + +A  L GRT LH  A  G       L+D  + V       +TP+H+A+  GHT+
Sbjct: 592 QPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTS 651

Query: 769 VLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPF--TP 826
             R LL      + + +     GY+ +H A+  GH   ++LL+E      L   P   T 
Sbjct: 652 TARLLLHRGAGKEAMTS----DGYTALHLAARNGHLATVKLLVEEKA-DVLARGPLNQTA 706

Query: 827 LHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVN 885
           LH A  +      E L+ A    +++  D +G + LH AA   +   +  LL+H A +N
Sbjct: 707 LHLAAAHGHSEVVEELVSA---DVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762



 Score = 93.6 bits (231), Expect = 9e-19
 Identities = 87/290 (30%), Positives = 125/290 (43%), Gaps = 48/290 (16%)

Query: 761  ASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLE-LLLEHSPFSYL 819
            A   G T+ L  +LQ       +D  +D SG S +H A   G E+C + LLL ++  +  
Sbjct: 413  AIVSGDTSKLMKILQP----QDVDLALD-SGASLLHLAVEAGQEECAKWLLLNNANPNLS 467

Query: 820  EGNPFTPLHCAVINNQDSTTEMLLGALGAKI-VNSRDAKGRTPLHAAAFADNVSGLRMLL 878
                 TPLH AV        E+LL     KI VN++D    T LH AA   + S  R+LL
Sbjct: 468  NRRGSTPLHMAVERRVRGVVELLLAR---KISVNAKDEDQWTALHFAAQNGDESSTRLLL 524

Query: 879  QHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENK------------- 925
            +  A VN  D  GRT +  A ++GQ   V  LL RG  D+++  ++              
Sbjct: 525  EKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRG-VDVSLQGKDAWLPLHYAAWQGHL 583

Query: 926  ---------------------NTALHLACSKGHEKCALMILAETQDLGLINATNSALQMP 964
                                  T LHLA  +GH + A +++    D   +N  +   Q P
Sbjct: 584  PIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD---VNVCSLLAQTP 640

Query: 965  LHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALI 1014
            LH+AA  G  S  + LL  GA   A+  +G+T     A N  +A    L+
Sbjct: 641  LHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLV 690



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 47/168 (27%), Positives = 70/168 (41%), Gaps = 34/168 (20%)

Query: 1   MGILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLL 60
           + + S+  Q PL  A  +      R LL +      +  +  T LH AA  G +  ++LL
Sbjct: 630 VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLL 689

Query: 61  LMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRAT 120
           +   A+V A+  L  T LH AAA  + +V+  L+  SADV                    
Sbjct: 690 VEEKADVLARGPLNQTALHLAAAHGHSEVVEELV--SADV-------------------- 727

Query: 121 KCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV 168
                       +++ D  G SALH A    H +TV  LL  GA +N+
Sbjct: 728 ------------IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINL 763



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 23/85 (27%), Positives = 43/85 (50%), Gaps = 1/85 (1%)

Query: 24  VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAA 83
           V+ L+ +K ++       +T LH AA  G   +++ L+ +   ++  D   L+ LH AA 
Sbjct: 686 VKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQ 744

Query: 84  SRNEKVLGLLLAHSADVNARDKLWQ 108
            R+ + +  LL H A +N +   +Q
Sbjct: 745 GRHAQTVETLLRHGAHINLQSLKFQ 769


>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
          Length = 1119

 Score =  165 bits (417), Expect = 2e-40
 Identities = 159/565 (28%), Positives = 245/565 (43%), Gaps = 64/565 (11%)

Query: 161 NKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYG--LLHTAAASGQ 218
           NK   L  CD  +   LH+AA  G +E+++ +    +     +   YG   LH A    Q
Sbjct: 51  NKQKKLKRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQ 110

Query: 219 IEVVKYLLRMGAEIDEPNAFGNTALHIACY-LGQDAVAIELVNAGANVNQPNDKGFTPLH 277
           IE VK+LL  GA  +  N      LHIA   +  + + + L +   +VN   + G T + 
Sbjct: 111 IESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAV- 169

Query: 278 VAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSE------ 331
           + A +TN +  L++L+  GA     +K G  P+H AA  G     +I+++ G E      
Sbjct: 170 IIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQ 229

Query: 332 --IDCADKFGNTPLHVAARYGHELLISTLMTNGA--DTARRGIHDMFPLHLAVLFGFSDC 387
             I+  +    TPLH+A + G   +I   + NGA  D   +G      +H A   G ++ 
Sbjct: 230 LHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKG--RCTAIHFAATQGATEI 287

Query: 388 CRKLLSSGQLYSIVSSLSNEHVLSAGFDI-NTPDNLGRTCLHAAASGGNVECLNLLLSSG 446
            + ++SS                S   DI NT D    T LH A+   + E  + L+S G
Sbjct: 288 VKLMISS---------------YSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVG 332

Query: 447 ADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE 506
           AD+ + D  GR+PL  A A+ S+     L++ GA V+  D  G + LH            
Sbjct: 333 ADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTV--------- 383

Query: 507 PHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNL 566
                       +P      +  F  ++ + +   D    D  G T +HYA   G   ++
Sbjct: 384 -----------QQPYGLKNLRPEFMQMQQIKELVMD---EDNDGCTPLHYACRQGGPGSV 429

Query: 567 ELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVN---LDVRDHKGRTALF 623
             LL   FN     +S    SPLH AA  G     + L + + +   L+  D  G T L 
Sbjct: 430 NNLL--GFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLH 487

Query: 624 LATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDV 683
           LA + G  + V++L   G  AL       WT LH A+  G+T ++ +++D+  +   TD 
Sbjct: 488 LAAKNGHDKVVQLLLKKG--ALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC--TDR 543

Query: 684 MDAYGQTPLMLAIMNGHVDCVHLLL 708
           +D  G T L  A   GH   V LLL
Sbjct: 544 LDEDGNTALHFAAREGHAKAVALLL 568



 Score =  151 bits (381), Expect = 4e-36
 Identities = 152/586 (25%), Positives = 254/586 (43%), Gaps = 69/586 (11%)

Query: 420 DNLGRTCLHAAASGGNVECLNLLL--SSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVT 477
           D++    LH AA+ G +E +  +   SS   L   D +G TPLH A      +    L++
Sbjct: 60  DDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLS 119

Query: 478 AGAGVNEADCKGCSPLHYAAA---SDTYRRAEPHTPSSHDAEEDEPLKE------SRRKE 528
            GA  N  +    +PLH A     ++  +    H     + E +           +   E
Sbjct: 120 RGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSE 179

Query: 529 AFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLL----------EMSFNCLE 578
           A   L+ LL  GA P   ++ G   +H AA  G+++ +E++L          ++  N + 
Sbjct: 180 A---LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMN 236

Query: 579 DVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLT 638
           + ++T    PLHLA  NG  E +K   +    +D  +    TA+  A  +G+TE V+++ 
Sbjct: 237 NGKAT----PLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMI 292

Query: 639 AH--GASALIKERKR-KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLA 695
           +   G+  ++        T LH A+   H +    LI  G  ADI  + D+ G++PL+LA
Sbjct: 293 SSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVG--ADINKI-DSEGRSPLILA 349

Query: 696 IMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGR 755
             +   + V+LLL KG+  D  D  GR  LH                            +
Sbjct: 350 TASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTV-------------------------Q 384

Query: 756 TPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSP 815
            P  L +       LR           L    D  G +P+H+A   G    +  LL  + 
Sbjct: 385 QPYGLKN-------LRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNV 437

Query: 816 FSYLEG-NPFTPLHCAVINNQDSTTEMLLGALG-AKIVNSRDAKGRTPLHAAAFADNVSG 873
             + +  +  +PLH A    + +T + LL  +   +++N  D  G TPLH AA   +   
Sbjct: 438 SIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKV 497

Query: 874 LRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLAC 933
           +++LL+  A +  +DH G TAL  A+  G T  ++ +L         LDE+ NTALH A 
Sbjct: 498 VQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAA 556

Query: 934 SKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQA 979
            +GH K   ++L+   D+ L     S L + LH   +  + +++++
Sbjct: 557 REGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRS 602



 Score =  149 bits (377), Expect = 1e-35
 Identities = 134/491 (27%), Positives = 219/491 (44%), Gaps = 42/491 (8%)

Query: 29  SQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEK 88
           S  E ++ +D    TPLH A     +  ++ LL  GAN N ++   + PLH A    N +
Sbjct: 86  SSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNE 145

Query: 89  VLGLLLAH-SADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHA 147
           V+ +LL H + DVN   +   T + +A     ++  + L    +    +++ G   +H A
Sbjct: 146 VMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQA 205

Query: 148 VHSGHLETVNLLLNKGAS--------LNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199
             SG  E + ++L  G          +N  +  +  PLH A   G LE++K+ +  GA +
Sbjct: 206 AFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQI 265

Query: 200 GCKDRKGYGLLHTAAASGQIEVVKYLL-RMGAEIDEPNAFG---NTALHIACYLGQDAVA 255
              ++     +H AA  G  E+VK ++      +D  N       T LH A       +A
Sbjct: 266 DPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELA 325

Query: 256 IELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAA- 314
             L++ GA++N+ + +G +PL +A  S +  + + LL++ GA V+ +   G++ LH+   
Sbjct: 326 DYLISVGADINKIDSEGRSPLILATASASWNI-VNLLLSKGAQVDIKDNFGRNFLHLTVQ 384

Query: 315 -------IHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTAR 367
                  +   F + Q   Q    +   D  G TPLH A R G    ++ L+        
Sbjct: 385 QPYGLKNLRPEFMQMQ---QIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHS 441

Query: 368 RGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCL 427
           +      PLH A  +G  + C++LL           +S+  +L+ G      D  G T L
Sbjct: 442 KSKDKKSPLHFAASYGRINTCQRLL---------QDISDTRLLNEG------DLHGMTPL 486

Query: 428 HAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQ-CAVTLVTAGAGVNEAD 486
           H AA  G+ + + LLL  GA L   D  G T LH+A+  G  Q   V L T     +  D
Sbjct: 487 HLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLD 545

Query: 487 CKGCSPLHYAA 497
             G + LH+AA
Sbjct: 546 EDGNTALHFAA 556



 Score =  137 bits (344), Expect = 7e-32
 Identities = 135/522 (25%), Positives = 226/522 (43%), Gaps = 78/522 (14%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGA-NVNA 69
           PL  A+    +E V+ LLS+  N N+ +     PLH A    +  ++++LL     +VN 
Sbjct: 101 PLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNL 160

Query: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
           +     T +  A  + N + L +LL   A     +K    P+H AA + + +C E +   
Sbjct: 161 EGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRF 220

Query: 130 LSS--------LNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAA 181
                      +N  +    + LH AV +G LE + + L+ GA ++  +K     +H+AA
Sbjct: 221 GEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAA 280

Query: 182 FLGHLEVLKL-------------------------------------LVARGADLGCKDR 204
             G  E++KL                                     L++ GAD+   D 
Sbjct: 281 TQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDS 340

Query: 205 KGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACY-------LGQDAVAIE 257
           +G   L  A AS    +V  LL  GA++D  + FG   LH+          L  + + ++
Sbjct: 341 EGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQ 400

Query: 258 LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHG 317
            +     +++ ND G TPLH A     G   +  L+     ++ +SK+ KSPLH AA +G
Sbjct: 401 QIKE-LVMDEDND-GCTPLHYAC-RQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYG 457

Query: 318 RFTRSQILIQNGSE---IDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMF 374
           R    Q L+Q+ S+   ++  D  G TPLH+AA+ GH+ ++  L+  GA       +   
Sbjct: 458 RINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWT 516

Query: 375 PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434
            LH A + G++   + +L +    +                 +  D  G T LH AA  G
Sbjct: 517 ALHHASMGGYTQTMKVILDTNLKCT-----------------DRLDEDGNTALHFAAREG 559

Query: 435 NVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLV 476
           + + + LLLS  AD+   +K   + LH A  N   +  +T++
Sbjct: 560 HAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEVVLTII 600



 Score =  123 bits (309), Expect = 8e-28
 Identities = 140/557 (25%), Positives = 227/557 (40%), Gaps = 109/557 (19%)

Query: 493 LHYAAASDTYRRAEPHTPSS-----HDAEE--DEPLKESRRKEAFFCLEFLLDNGADPSL 545
           LHYAAA       E  T  S     H+ ++  + PL  +  K     ++FLL  GA+P+L
Sbjct: 67  LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126

Query: 546 RDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLA 605
           R+                          FN +         +PLH+A    + E +K L 
Sbjct: 127 RN--------------------------FNMM---------APLHIAVQGMNNEVMKVLL 151

Query: 606 E-TLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWT--PLHAAAAS 662
           E   +++++    G TA+ +A    ++E +++L   GA      +  KW   P+H AA S
Sbjct: 152 EHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPC---KSNKWGCFPIHQAAFS 208

Query: 663 GHTDSLHLLIDSGERADIT-----DVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAA 717
           G  + + +++  GE    +     + M+    TPL LA+ NG ++ + + L+ G+  D  
Sbjct: 209 GSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPV 268

Query: 718 DLRGRTALHRGAVTGCEDCLAALLDHDA----FVLCRDFKGRTPIHLASACGHTAVLRTL 773
           +    TA+H  A  G  + +  ++   +     V   D    T +H AS   H  +   L
Sbjct: 269 EKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYL 328

Query: 774 LQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGN----------- 822
           +      + +D+     G SP+  A+ +   + + LLL       ++ N           
Sbjct: 329 ISVGADINKIDS----EGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQ 384

Query: 823 -PF---------------------------TPLHCAVINNQDSTTEMLLGALGAKIVNSR 854
            P+                           TPLH A       +   LLG   +    S+
Sbjct: 385 QPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSK 444

Query: 855 DAKGRTPLHAAAFADNVSGLRMLLQHQAE---VNATDHTGRTALMTAAENGQTAAVEFLL 911
           D K  +PLH AA    ++  + LLQ  ++   +N  D  G T L  AA+NG    V+ LL
Sbjct: 445 DKK--SPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLL 502

Query: 912 YRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARN 971
            +G   L+  D N  TALH A   G+ +   +IL    +L   +  +      LH AAR 
Sbjct: 503 KKGALFLS--DHNGWTALHHASMGGYTQTMKVIL--DTNLKCTDRLDEDGNTALHFAARE 558

Query: 972 GLASVVQALLSHGATVL 988
           G A  V  LLSH A ++
Sbjct: 559 GHAKAVALLLSHNADIV 575


>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
            [Homo sapiens]
          Length = 1170

 Score =  162 bits (410), Expect = 2e-39
 Identities = 227/863 (26%), Positives = 344/863 (39%), Gaps = 104/863 (12%)

Query: 26   SLLSQKENINVLDQERRTPLHAAAYVG--DVPILQLLLMSG---ANVNAKDTLWLTPLHR 80
            S +S +    ++  +   PLH A  V   DV  L L+ M       +N  D      L  
Sbjct: 203  SSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDL 262

Query: 81   AAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSG 140
            A + R E +   L++H ADV+  DK   + LH          A  L    + +N A    
Sbjct: 263  ALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGA 322

Query: 141  RSALHHAV-------HSGHL-----ETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEV 188
            +    H V       HS  +     +    LL  GA+ N+ D K R PLH +   G+  V
Sbjct: 323  QETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYV 382

Query: 189  L-KLLVARGADLGCKDRKGYGLL-----HTAAASGQ-------IEVVK-----------Y 224
              +LL  +  DL  KD +G   L     H   +S Q       + VV             
Sbjct: 383  FSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAAR 442

Query: 225  LLRMGAEIDEPN-AFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVST 283
            L++ G+  D P+ A GN  L  A   G +A A+ L   GA+VN  N  G TPLH A    
Sbjct: 443  LIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHG 502

Query: 284  NGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPL 343
               L  ELL   GA+ N Q++E   PL   A         + +Q             TPL
Sbjct: 503  LANLTAELL-QQGANPNLQTEEA-LPLPKEAASLTSLADSVHLQ-------------TPL 547

Query: 344  HVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSS 403
            H+A  Y H  ++S ++   A+     +H    L +   F   D   + +    L++ + +
Sbjct: 548  HMAIAYNHPDVVSVILEQKAN----ALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHT 603

Query: 404  LSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLR-RRDKFGRTPLHY 462
            ++ + +L +G  IN   + G+T LH A    + +    LL   AD+   R + G T L  
Sbjct: 604  IAAQ-LLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQL 662

Query: 463  AAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEP-- 520
            A  N        + T GA ++  D KG  PL  A A++    A        DA    P  
Sbjct: 663  AIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGP 722

Query: 521  -----------LKESRRKEAFFCLEFLLD---------NGADPSLRDRQGYTAVHYAAAY 560
                       + E+    A F +    D         NG +     R G T +H AA++
Sbjct: 723  GGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANG-EGEEEARDGQTPLHLAASW 781

Query: 561  GNRQNLELLLEMSFNC-LEDVESTIPVSPLHLAAYNGHCEALKTL-AETLVNLDVRDHKG 618
            G  + ++ LLE   N   +D E     +P+H+A  + H   ++ L +   ++L+VRD +G
Sbjct: 782  GLEETVQCLLEFGANVNAQDAEGR---TPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQG 838

Query: 619  RTALFLATERGSTECVEVLTAH--GASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGE 676
             T    A    + +  E +     GA+  +  + R +  LH A  +   +S+  LI    
Sbjct: 839  LTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNF--LHVAVQNSDIESVLFLISVHA 896

Query: 677  RADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDC 736
              + + V DA   TPL LA+  G    V  LL  G+  +      +TALH  A       
Sbjct: 897  NVN-SRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTI 955

Query: 737  LAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDA-GVDYSGYSPM 795
             + LL++       D  G   +HLA   G    +R LL        +DA   +  G SP+
Sbjct: 956  CSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTEC----TVDAEAFNLRGQSPL 1011

Query: 796  HWASYTGHEDC---LELLLEHSP 815
            H     G E+     +L LE  P
Sbjct: 1012 HILGQYGKENAAAIFDLFLECMP 1034



 Score =  160 bits (404), Expect = 8e-39
 Identities = 256/972 (26%), Positives = 376/972 (38%), Gaps = 121/972 (12%)

Query: 100  VNARD--KLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSA-------------- 143
            VN R+  + +QT   + A+     CAE +A     L   D S  SA              
Sbjct: 162  VNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYP 221

Query: 144  LHHAVHSGHLETVNLLLNKGAS-----LNVCDKKERQPLHWAAFLGHLEVLKLLVARGAD 198
            LH A+     + V L L +  S     LN  D      L  A       +   LV+  AD
Sbjct: 222  LHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKAD 281

Query: 199  LGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIEL 258
            +   D+ G+ LLH     G +    +L++ GA ++            A  LG     + L
Sbjct: 282  VDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVN------------AATLGAQETPLHL 329

Query: 259  VNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGR 318
            V   ++            H A V +  A   E L+  GA+ N Q  +G++PLH++ + G 
Sbjct: 330  VALYSSKK----------HSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGN 379

Query: 319  -FTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLH 377
             +  SQ+L     +++  D  G+T L +A ++         +T  +D +     D+ P+ 
Sbjct: 380  EYVFSQLLQCKQLDLELKDHEGSTALWLAVQH---------ITVSSDQSVNPFEDV-PVV 429

Query: 378  LAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCL-HAAASGGNV 436
                F  +    +L+  G                     + PD     CL   AA  GN 
Sbjct: 430  NGTSFDENSFAARLIQRGS------------------HTDAPDTATGNCLLQRAAGAGNE 471

Query: 437  ECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYA 496
                 L ++GA +  R+K+G TPLH A  +G       L+  GA  N    +   PL   
Sbjct: 472  AAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPN-LQTEEALPLPKE 530

Query: 497  AASDTYRRAEPH--TPSSHDAEEDEPLKES---RRKEAFFCLEFLLDNGADPSLRDRQGY 551
            AAS T      H  TP       + P   S    +K         L    D SL+D +  
Sbjct: 531  AASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQ 590

Query: 552  TAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNL 611
            T +  A   G       LL  S   + D  S    + LH+A      ++   L E   ++
Sbjct: 591  TVLGLALWTGMHTIAAQLLG-SGAAINDTMSD-GQTLLHMAIQRQDSKSALFLLEHQADI 648

Query: 612  DV-RDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHL 670
            +V R   G TAL LA        V+ +   GA   + + K    PL  A A+   D    
Sbjct: 649  NVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGN-PPLWLALANNLEDIAST 707

Query: 671  LIDSGERADITDVMDAYG---QTPLMLAIMNGHVDCVHLLLEKGSTADAA---------- 717
            L+  G   D T      G   QT L  AI   +      L+  G   ++           
Sbjct: 708  LVRHG--CDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGE 765

Query: 718  -DLR-GRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQ 775
             + R G+T LH  A  G E+ +  LL+  A V  +D +GRTPIH+A +  H  +++ L  
Sbjct: 766  EEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLL-- 823

Query: 776  AALSTDPLDAGV-DYSGYSPMHWASYTGHEDCLELLL--EHSPFSYLEGNPFTPLHCAVI 832
              +S   +   V D  G +P   A    +    E +L  E      ++      LH AV 
Sbjct: 824  --VSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAV- 880

Query: 833  NNQDSTTEMLLGALGAKIVNSR--DAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT 890
             N D  + + L ++ A  VNSR  DA   TPLH A  A +   +R LL   A+VN     
Sbjct: 881  QNSDIESVLFLISVHAN-VNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKH 939

Query: 891  GRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAE-TQ 949
             +TAL  AA+         LL  G  D   +DEN N ALHLA   G      ++L E T 
Sbjct: 940  RQTALHLAAQQDLPTICSVLLENG-VDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTV 998

Query: 950  DLGLINATNSALQMPLHIAARNG---LASVVQALLS--HGATVLAVDEEGHTPALACAPN 1004
            D     A N   Q PLHI  + G    A++    L    G  +   D +G T  L     
Sbjct: 999  D---AEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMK 1055

Query: 1005 KDVADCLALILS 1016
             +   C A++ S
Sbjct: 1056 GNANLCRAIVRS 1067



 Score =  144 bits (363), Expect = 4e-34
 Identities = 199/821 (24%), Positives = 328/821 (39%), Gaps = 161/821 (19%)

Query: 41   RRTPLHAAA------YVGDV-----PILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKV 89
            + TPLH  A      +  DV      I + LL +GAN N +D+   TPLH +  + NE V
Sbjct: 323  QETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYV 382

Query: 90   LG-LLLAHSADVNARD-----KLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS---- 139
               LL     D+  +D      LW    H+  ++  +       P+++  +  + S    
Sbjct: 383  FSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAAR 442

Query: 140  ---------------GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLG 184
                           G   L  A  +G+      L   GA +N  +K    PLH A   G
Sbjct: 443  LIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHG 502

Query: 185  HLEVLKLLVARGADLGCKDRKGYGL-------------------LHTAAASGQIEVVKYL 225
               +   L+ +GA+   +  +   L                   LH A A    +VV  +
Sbjct: 503  LANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVI 562

Query: 226  LRMGA-------------EIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272
            L   A             +    ++   T L +A + G   +A +L+ +GA +N     G
Sbjct: 563  LEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDG 622

Query: 273  FTPLHVAAVSTNGALCLELLVNNGADVNY-QSKEGKSPLHMAAIHGRFTRSQILIQNGSE 331
             T LH+A    +    L  L+ + AD+N  ++++G++ L +A  +        +   G++
Sbjct: 623  QTLLHMAIQRQDSKSAL-FLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGAD 681

Query: 332  IDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKL 391
            +   D+ GN PL +A     E + STL+ +G D    G             G   C + L
Sbjct: 682  MSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGP------------GPGGCLQTL 729

Query: 392  LSSGQLYSIVSSLSNE----HVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGA 447
            L            +NE     ++ +G D+N+P   G       A+G   E          
Sbjct: 730  LHR------AIDENNEPTACFLIRSGCDVNSPRQPG-------ANGEGEE---------- 766

Query: 448  DLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEP 507
                RD  G+TPLH AA+ G  +    L+  GA VN  D +G +P+H A +S        
Sbjct: 767  --EARD--GQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISS-------- 814

Query: 508  HTPSSHDAEEDEPLKESRRKEAFFCLEFLLDN-GADPSLRDRQGYTAVHYAAAYGNRQNL 566
                                +    ++ L+ +     ++RDRQG T    A  + N ++ 
Sbjct: 815  --------------------QHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSA 854

Query: 567  ELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLD--VRDHKGRTALFL 624
            E +L+      E V++    + LH+A  N   E++  L     N++  V+D    T L L
Sbjct: 855  EAILKRESGAAEQVDNK-GRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHL 913

Query: 625  ATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVM 684
            A + GS   V  L   GA  + +  K + T LH AA         +L+++G   D   V 
Sbjct: 914  AVQAGSEIIVRNLLLAGAK-VNELTKHRQTALHLAAQQDLPTICSVLLENG--VDFAAV- 969

Query: 685  DAYGQTPLMLAIMNGHVDCVHLLLEKGST-ADAADLRGRTALHRGAVTGCEDCLAALLDH 743
            D  G   L LA+M+G ++ + +LL + +  A+A +LRG++ LH     G E+  A     
Sbjct: 970  DENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIF--- 1026

Query: 744  DAFVLCR--------DFKGRTPIHLASACGHTAVLRTLLQA 776
            D F+ C         D  G T + LA   G+  + R ++++
Sbjct: 1027 DLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRS 1067



 Score =  136 bits (342), Expect = 1e-31
 Identities = 157/596 (26%), Positives = 246/596 (41%), Gaps = 71/596 (11%)

Query: 22   EEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGAN-VNAKDTLWLTPLHR 80
            +E  SL S  +++++     +TPLH A       ++ ++L   AN ++A + L + P   
Sbjct: 529  KEAASLTSLADSVHL-----QTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFS 583

Query: 81   AAASRNEKVLGL------------LLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128
               SR++ VLGL            LL   A +N      QT LH+A   + +K A  L  
Sbjct: 584  LKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLE 643

Query: 129  LLSSLNVA-DRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLE 187
              + +NV+  + G +AL  A+ +     V+ +  +GA ++V D+K   PL W A   +LE
Sbjct: 644  HQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPL-WLALANNLE 702

Query: 188  -VLKLLVARGADLGCKDRKGYG----LLHTAAASGQIEVVKYLLRMGAEIDEPNA----- 237
             +   LV  G D  C      G    LLH A          +L+R G +++ P       
Sbjct: 703  DIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANG 762

Query: 238  -------FGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLE 290
                    G T LH+A   G +     L+  GANVN  + +G TP+HVA  S +G +   
Sbjct: 763  EGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQL 822

Query: 291  LLVNNGADVNYQSKEGKSPLHMA-AIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARY 349
            L+ +    +N + ++G +P   A       +   IL +     +  D  G   LHVA + 
Sbjct: 823  LVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQN 882

Query: 350  GHELLISTLMTNGADTARR--GIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNE 407
                 +  L++  A+   R      + PLHLAV  G                  S +   
Sbjct: 883  SDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAG------------------SEIIVR 924

Query: 408  HVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANG 467
            ++L AG  +N      +T LH AA        ++LL +G D    D+ G   LH A  +G
Sbjct: 925  NLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHG 984

Query: 468  SYQCAVTLVTAGAGVNEA-DCKGCSPLHY---------AAASDTYRRAEPHTP-SSHDAE 516
                   L+T      EA + +G SPLH          AA  D +    P  P    DA+
Sbjct: 985  RLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDAD 1044

Query: 517  EDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEM 572
                L  +  K        ++ +GA   + + QG    +Y  A   +Q L  LL+M
Sbjct: 1045 GSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVA--TKQLLFRLLDM 1098



 Score =  132 bits (333), Expect = 1e-30
 Identities = 172/676 (25%), Positives = 260/676 (38%), Gaps = 142/676 (21%)

Query: 60   LLMSGANVNAKDTLWLTPL-HRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVA---- 114
            L+  G++ +A DT     L  RAA + NE     L  + A VN R+K  +TPLH A    
Sbjct: 443  LIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHG 502

Query: 115  -----------AANRATKCAEALAPL----LSSLNVADRSG-RSALHHAVHSGHLETVNL 158
                        AN   +  EAL PL     S  ++AD    ++ LH A+   H + V++
Sbjct: 503  LANLTAELLQQGANPNLQTEEAL-PLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSV 561

Query: 159  LLNKGAS-------------LNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRK 205
            +L + A+              ++ D +++  L  A + G   +   L+  GA +      
Sbjct: 562  ILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSD 621

Query: 206  GYGLLHTAAASGQIEVVKYLLRMGAEID-EPNAFGNTALHIACYLGQDAVAIELVNAGAN 264
            G  LLH A      +   +LL   A+I+      G TAL +A       V   +   GA+
Sbjct: 622  GQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGAD 681

Query: 265  VNQPNDKGFTPLHVA------------------------------------AVSTNGALC 288
            ++ P++KG  PL +A                                    A+  N    
Sbjct: 682  MSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPT 741

Query: 289  LELLVNNGADVN------------YQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCAD 336
               L+ +G DVN             ++++G++PLH+AA  G     Q L++ G+ ++  D
Sbjct: 742  ACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQD 801

Query: 337  KFGNTPLHVAARYGHELLISTLMTN-GADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSG 395
              G TP+HVA    H ++I  L+++       R    + P   A+ F  +     +L   
Sbjct: 802  AEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKR- 860

Query: 396  QLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRR--D 453
                   S + E V          DN GR  LH A    ++E +  L+S  A++  R  D
Sbjct: 861  ------ESGAAEQV----------DNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQD 904

Query: 454  KFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSH 513
                TPLH A   GS      L+ AGA VNE      + LH A                 
Sbjct: 905  ASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLA----------------- 947

Query: 514  DAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMS 573
             A++D P               LL+NG D +  D  G  A+H A  +G   N+ +LL   
Sbjct: 948  -AQQDLPT----------ICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLT-- 994

Query: 574  FNCLEDVE--STIPVSPLHLAAYNGHCEALKTLAETL-----VNLDVRDHKGRTALFLAT 626
              C  D E  +    SPLH+    G   A       L       LD  D  G T L LA 
Sbjct: 995  -ECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAY 1053

Query: 627  ERGSTECVEVLTAHGA 642
             +G+      +   GA
Sbjct: 1054 MKGNANLCRAIVRSGA 1069



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 45/164 (27%), Positives = 64/164 (39%), Gaps = 6/164 (3%)

Query: 11   PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
            PL  A+ +     VR+LL     +N L + R+T LH AA      I  +LL +G +  A 
Sbjct: 910  PLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAV 969

Query: 71   DTLWLTPLHRAAA-SRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
            D      LH A    R   +  LL   + D  A +   Q+PLH+         A      
Sbjct: 970  DENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLF 1029

Query: 130  LS-----SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV 168
            L       L+  D  G + L  A   G+      ++  GA L V
Sbjct: 1030 LECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGV 1073


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score =  156 bits (395), Expect = 9e-38
 Identities = 110/307 (35%), Positives = 148/307 (48%), Gaps = 12/307 (3%)

Query: 93  LLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGH 152
           LL   A V  RD   +TPLH+A           L    + +   DR+GR+ALH A   GH
Sbjct: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119

Query: 153 LETVNLLLNKGASLNVCDKKERQPLHWAAFLGH-LEVLKLLVARG---ADLGCKDRKGYG 208
                LLL +GAS          PLHWAA LGH L   +LL A G   A    +D +G+ 
Sbjct: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179

Query: 209 LLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQP 268
             H AAA G++ V++ L   GA +D        AL +A   G+ A    L+  GA V+  
Sbjct: 180 AAHWAAAGGRLAVLELLAAGGAGLDG-------ALLVAAAAGRGAALRFLLARGARVDAR 232

Query: 269 NDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQN 328
           +  G T L +AA +   +  +E+L+ +GAD   + + G+S LH AA  G     Q+L+  
Sbjct: 233 DGAGATALGLAA-ALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQ 291

Query: 329 GSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCC 388
           G+E+D  D  G TPLH A+R GH  +   L+  GA     G     PLHLA   G     
Sbjct: 292 GAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTV 351

Query: 389 RKLLSSG 395
             LLS G
Sbjct: 352 GLLLSRG 358



 Score =  142 bits (359), Expect = 1e-33
 Identities = 109/325 (33%), Positives = 158/325 (48%), Gaps = 12/325 (3%)

Query: 48  AAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLW 107
           A + G   ++  LL  GA+V  +D    TPLH A    +  ++ LLL   A V A D+  
Sbjct: 48  AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107

Query: 108 QTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGH-LETVNLLLNKG--- 163
           +T LH AA +  ++ AE L    +S      +G + LH A   GH L    LL   G   
Sbjct: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGP 167

Query: 164 ASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVK 223
           A+    D +     HWAA  G L VL+LL A GA L        G L  AAA+G+   ++
Sbjct: 168 AAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALR 220

Query: 224 YLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVST 283
           +LL  GA +D  +  G TAL +A  LG+      L+  GA+    +  G + LH AA   
Sbjct: 221 FLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280

Query: 284 NGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPL 343
           +  L ++LLV  GA+V+ +   G +PLH A+  G    +  L+  G+++D       TPL
Sbjct: 281 H-LLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPL 339

Query: 344 HVAARYGHELLISTLMTNGADTARR 368
           H+AA  GH   +  L++ GA    R
Sbjct: 340 HLAAERGHGPTVGLLLSRGASPTLR 364



 Score =  138 bits (348), Expect = 2e-32
 Identities = 109/303 (35%), Positives = 146/303 (48%), Gaps = 14/303 (4%)

Query: 685 DAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHD 744
           D  G+TPL LA++ GH   V LLL++G+   A D  GRTALH  A  G       LL   
Sbjct: 71  DHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRG 130

Query: 745 AFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHE 804
           A    R   G TP+H A+A GHT +   LL+A           D  G++  HWA+  G  
Sbjct: 131 ASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRL 190

Query: 805 DCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHA 864
             LELL      + L+G     L  A    + +    LL A GA+ V++RD  G T L  
Sbjct: 191 AVLELLAAGG--AGLDG----ALLVAAAAGRGAALRFLL-ARGAR-VDARDGAGATALGL 242

Query: 865 AAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDEN 924
           AA       + +LL H A+    D  GR+AL  AA  G   AV+ L+ +G A++   D  
Sbjct: 243 AAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQG-AEVDARDTL 301

Query: 925 KNTALHLACSKGHEKCALMILAETQDLGL-INATNSALQMPLHIAARNGLASVVQALLSH 983
             T LH A  +GH + A  +L    D G  ++AT    + PLH+AA  G    V  LLS 
Sbjct: 302 GLTPLHHASREGHVEVAGCLL----DRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSR 357

Query: 984 GAT 986
           GA+
Sbjct: 358 GAS 360



 Score =  137 bits (346), Expect = 4e-32
 Identities = 113/345 (32%), Positives = 155/345 (44%), Gaps = 30/345 (8%)

Query: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199
           G   L  AV  G    V  LL +GAS+   D   R PLH A   GH  +++LL+ RGA +
Sbjct: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100

Query: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV 259
           G  DR G   LH AA  G   V + LL+ GA     +  G T LH A  LG   +A  L+
Sbjct: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160

Query: 260 NAG----ANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAI 315
            A     A     + +G+T  H AA     A+ LELL   GA ++         L +AA 
Sbjct: 161 EAPGPGPAAAEAEDARGWTAAHWAAAGGRLAV-LELLAAGGAGLD-------GALLVAAA 212

Query: 316 HGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFP 375
            GR    + L+  G+ +D  D  G T L +AA  G    I  L+ +GAD   R  H    
Sbjct: 213 AGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSA 272

Query: 376 LHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGN 435
           LH A             + G L ++      + +++ G +++  D LG T LH A+  G+
Sbjct: 273 LHRAA------------ARGHLLAV------QLLVTQGAEVDARDTLGLTPLHHASREGH 314

Query: 436 VECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480
           VE    LL  GA +       +TPLH AA  G       L++ GA
Sbjct: 315 VEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359



 Score =  134 bits (338), Expect = 4e-31
 Identities = 109/316 (34%), Positives = 145/316 (45%), Gaps = 31/316 (9%)

Query: 12  LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD 71
           L+QA++      V  LL Q  ++   D   RTPLH A   G  P+++LLL  GA V A D
Sbjct: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104

Query: 72  TLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCA----EALA 127
               T LH AA   + +V  LLL   A   AR     TPLH AAA   T  A    EA  
Sbjct: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164

Query: 128 PLLSSLNVADRSGRSALHHAVHSGHLETVNLL--------------------------LN 161
           P  ++    D  G +A H A   G L  + LL                          L 
Sbjct: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLA 224

Query: 162 KGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEV 221
           +GA ++  D      L  AA LG  + +++L+  GAD G +DR G   LH AAA G +  
Sbjct: 225 RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLA 284

Query: 222 VKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAV 281
           V+ L+  GAE+D  +  G T LH A   G   VA  L++ GA V+       TPLH+AA 
Sbjct: 285 VQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAE 344

Query: 282 STNGALCLELLVNNGA 297
             +G   + LL++ GA
Sbjct: 345 RGHGP-TVGLLLSRGA 359



 Score =  133 bits (334), Expect = 1e-30
 Identities = 114/340 (33%), Positives = 151/340 (44%), Gaps = 43/340 (12%)

Query: 409 VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468
           +L  G  +   D+ GRT LH A   G+   + LLL  GA +   D+ GRT LH AA +G 
Sbjct: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119

Query: 469 YQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKE 528
            + A  L+  GA        G +PLH+AAA         HT           L  +R  E
Sbjct: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALG-------HT-----------LLAARLLE 161

Query: 529 AFFCLEFLLDNGADPS---LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIP 585
           A          G  P+     D +G+TA H+AAA G    LELL                
Sbjct: 162 A---------PGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGL--------- 203

Query: 586 VSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL 645
              L +AA  G   AL+ L      +D RD  G TAL LA   G ++ +EVL  HGA   
Sbjct: 204 DGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPG 263

Query: 646 IKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVH 705
           I++R  + + LH AAA GH  ++ LL+  G   D  D +   G TPL  A   GHV+   
Sbjct: 264 IRDRHGR-SALHRAAARGHLLAVQLLVTQGAEVDARDTL---GLTPLHHASREGHVEVAG 319

Query: 706 LLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDA 745
            LL++G+  DA     +T LH  A  G    +  LL   A
Sbjct: 320 CLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359



 Score =  118 bits (296), Expect = 3e-26
 Identities = 99/321 (30%), Positives = 139/321 (43%), Gaps = 28/321 (8%)

Query: 180 AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFG 239
           A + G   ++  L+ +GA +  +D  G   LH A   G   +V+ LL+ GA +   +  G
Sbjct: 48  AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107

Query: 240 NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNG--- 296
            TALH A + G   VA  L+  GA+    +  G TPLH AA   +  L   LL   G   
Sbjct: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGP 167

Query: 297 ADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLIS 356
           A    +   G +  H AA  GR    ++L   G+ +D A       L VAA  G    + 
Sbjct: 168 AAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALR 220

Query: 357 TLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDI 416
            L+  GA    R       L LA   G S     LL  G                   D 
Sbjct: 221 FLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGA------------------DP 262

Query: 417 NTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLV 476
              D  GR+ LH AA+ G++  + LL++ GA++  RD  G TPLH+A+  G  + A  L+
Sbjct: 263 GIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL 322

Query: 477 TAGAGVNEADCKGCSPLHYAA 497
             GA V+       +PLH AA
Sbjct: 323 DRGAQVDATGWLRKTPLHLAA 343



 Score =  115 bits (289), Expect = 2e-25
 Identities = 108/347 (31%), Positives = 156/347 (44%), Gaps = 25/347 (7%)

Query: 675  GERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCE 734
            G R +   V+  +G   L+ A+  G    V  LL +G++ +  D  GRT LH   + G  
Sbjct: 30   GTRTEGPSVVQGWGH--LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHA 87

Query: 735  DCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSP 794
              +  LL   A V   D  GRT +H A+  GH+ V   LLQ   S     A    +G +P
Sbjct: 88   PLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASA----AARSGTGLTP 143

Query: 795  MHWASYTGHEDCLELLLE-----HSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAK 849
            +HWA+  GH      LLE      +     +   +T  H A    + +  E LL A GA 
Sbjct: 144  LHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLE-LLAAGGAG 202

Query: 850  IVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 909
            +  +        L  AA A   + LR LL   A V+A D  G TAL  AA  G++  +E 
Sbjct: 203  LDGA--------LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEV 254

Query: 910  LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969
            LL  G AD  + D +  +ALH A ++GH     +++ +  +   ++A ++    PLH A+
Sbjct: 255  LLGHG-ADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAE---VDARDTLGLTPLHHAS 310

Query: 970  RNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILS 1016
            R G   V   LL  GA V A      TP L  A  +     + L+LS
Sbjct: 311  REGHVEVAGCLLDRGAQVDATGWLRKTP-LHLAAERGHGPTVGLLLS 356



 Score =  109 bits (273), Expect = 1e-23
 Identities = 98/329 (29%), Positives = 132/329 (40%), Gaps = 55/329 (16%)

Query: 354 LISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAG 413
           L++ L+  GA    R      PLHLAVL G +   R LL  G                  
Sbjct: 56  LVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGA----------------- 98

Query: 414 FDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAV 473
             +   D  GRT LH AA  G+     LLL  GA    R   G TPLH+AAA G    A 
Sbjct: 99  -PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAA 157

Query: 474 TLVTA---GAGVNEA-DCKGCSPLHYAAASDT---------------------------- 501
            L+ A   G    EA D +G +  H+AAA                               
Sbjct: 158 RLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGA 217

Query: 502 ---YRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAA 558
              +  A      + D      L  +        +E LL +GADP +RDR G +A+H AA
Sbjct: 218 ALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAA 277

Query: 559 AYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKG 618
           A G+   ++LL+        D   T+ ++PLH A+  GH E    L +    +D      
Sbjct: 278 ARGHLLAVQLLVTQGAEV--DARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLR 335

Query: 619 RTALFLATERGSTECVEVLTAHGASALIK 647
           +T L LA ERG    V +L + GAS  ++
Sbjct: 336 KTPLHLAAERGHGPTVGLLLSRGASPTLR 364



 Score =  108 bits (270), Expect = 3e-23
 Identities = 103/340 (30%), Positives = 136/340 (40%), Gaps = 41/340 (12%)

Query: 442 LLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDT 501
           LL  GA +  RD  GRTPLH A   G       L+  GA V   D  G + LH AA    
Sbjct: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119

Query: 502 YRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYG 561
            R AE                             LL  GA  + R   G T +H+AAA G
Sbjct: 120 SRVAE----------------------------LLLQRGASAAARSGTGLTPLHWAAALG 151

Query: 562 NRQNLELLLEMSFN--CLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGR 619
           +      LLE         + E     +  H AA  G    L+ LA     LD       
Sbjct: 152 HTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD------- 204

Query: 620 TALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERAD 679
            AL +A   G    +  L A GA    ++     T L  AAA G +  + +L+  G  AD
Sbjct: 205 GALLVAAAAGRGAALRFLLARGARVDARDGAGA-TALGLAAALGRSQDIEVLLGHG--AD 261

Query: 680 ITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAA 739
              + D +G++ L  A   GH+  V LL+ +G+  DA D  G T LH  +  G  +    
Sbjct: 262 -PGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGC 320

Query: 740 LLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALS 779
           LLD  A V    +  +TP+HLA+  GH   +  LL    S
Sbjct: 321 LLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360



 Score =  108 bits (270), Expect = 3e-23
 Identities = 89/284 (31%), Positives = 124/284 (43%), Gaps = 30/284 (10%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
           PL  A+       VR LL +   +  +D+  RT LH AA+ G   + +LLL  GA+  A+
Sbjct: 77  PLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAAR 136

Query: 71  DTLWLTPLHRAAASRNEKVLGLLLAHS----ADVNARDKLWQTPLHVAAANRATKCAEAL 126
               LTPLH AAA  +  +   LL       A   A D    T  H AAA       E L
Sbjct: 137 SGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELL 196

Query: 127 APLLSSLNVA--------------------------DRSGRSALHHAVHSGHLETVNLLL 160
           A   + L+ A                          D +G +AL  A   G  + + +LL
Sbjct: 197 AAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLL 256

Query: 161 NKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIE 220
             GA   + D+  R  LH AA  GHL  ++LLV +GA++  +D  G   LH A+  G +E
Sbjct: 257 GHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVE 316

Query: 221 VVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGAN 264
           V   LL  GA++D       T LH+A   G       L++ GA+
Sbjct: 317 VAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360



 Score =  107 bits (266), Expect = 8e-23
 Identities = 108/344 (31%), Positives = 139/344 (40%), Gaps = 55/344 (15%)

Query: 475 LVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLE 534
           L+  GA V E D  G +PLH A           H P                      + 
Sbjct: 60  LLRQGASVEERDHAGRTPLHLAVLRG-------HAP---------------------LVR 91

Query: 535 FLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAY 594
            LL  GA     DR G TA+H AA +G+ +  ELLL+   +      S   ++PLH AA 
Sbjct: 92  LLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAA--ARSGTGLTPLHWAAA 149

Query: 595 NGHCEALKTLAETL----VNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERK 650
            GH      L E         +  D +G TA   A   G    +E+L A GA        
Sbjct: 150 LGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD----- 204

Query: 651 RKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710
                L  AAA+G   +L  L+  G R D     D  G T L LA   G    + +LL  
Sbjct: 205 ---GALLVAAAAGRGAALRFLLARGARVD---ARDGAGATALGLAAALGRSQDIEVLLGH 258

Query: 711 GSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVL 770
           G+     D  GR+ALHR A  G    +  L+   A V  RD  G TP+H AS  GH  V 
Sbjct: 259 GADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVA 318

Query: 771 RTLLQAALSTDPLDAGVDYSGY---SPMHWASYTGHEDCLELLL 811
             LL          A VD +G+   +P+H A+  GH   + LLL
Sbjct: 319 GCLLDRG-------AQVDATGWLRKTPLHLAAERGHGPTVGLLL 355



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 103/328 (31%), Positives = 140/328 (42%), Gaps = 22/328 (6%)

Query: 592 AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651
           A + G    +  L     +++ RDH GRT L LA  RG    V +L   GA     +R  
Sbjct: 48  AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107

Query: 652 KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK- 710
           + T LH AA  GH+    LL+  G  A         G TPL  A   GH      LLE  
Sbjct: 108 R-TALHEAAWHGHSRVAELLLQRGASA---AARSGTGLTPLHWAAALGHTLLAARLLEAP 163

Query: 711 ---GSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHT 767
               + A+A D RG TA H  A  G    L  L    A +          + +A+A G  
Sbjct: 164 GPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGL-------DGALLVAAAAGRG 216

Query: 768 AVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYL-EGNPFTP 826
           A LR LL      D  D     +G + +  A+  G    +E+LL H     + + +  + 
Sbjct: 217 AALRFLLARGARVDARDG----AGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSA 272

Query: 827 LHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNA 886
           LH A         ++L+   GA+ V++RD  G TPLH A+   +V     LL   A+V+A
Sbjct: 273 LHRAAARGHLLAVQLLV-TQGAE-VDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDA 330

Query: 887 TDHTGRTALMTAAENGQTAAVEFLLYRG 914
           T    +T L  AAE G    V  LL RG
Sbjct: 331 TGWLRKTPLHLAAERGHGPTVGLLLSRG 358



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 49/158 (31%), Positives = 63/158 (39%), Gaps = 8/158 (5%)

Query: 845 ALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQT 904
           ALG +       +G   L  A +      +  LL+  A V   DH GRT L  A   G  
Sbjct: 28  ALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHA 87

Query: 905 AAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMP 964
             V  LL RG A +  +D    TALH A   GH + A ++L         + T      P
Sbjct: 88  PLVRLLLQRG-APVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLT---P 143

Query: 965 LHIAARNG----LASVVQALLSHGATVLAVDEEGHTPA 998
           LH AA  G     A +++A     A   A D  G T A
Sbjct: 144 LHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAA 181



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 30/80 (37%), Positives = 41/80 (51%)

Query: 24  VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAA 83
           V+ L++Q   ++  D    TPLH A+  G V +   LL  GA V+A   L  TPLH AA 
Sbjct: 285 VQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAE 344

Query: 84  SRNEKVLGLLLAHSADVNAR 103
             +   +GLLL+  A    R
Sbjct: 345 RGHGPTVGLLLSRGASPTLR 364


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score =  154 bits (388), Expect = 6e-37
 Identities = 121/416 (29%), Positives = 192/416 (46%), Gaps = 46/416 (11%)

Query: 32  ENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLG 91
           E   +L  ER+  LH AA   +V  +Q L+    N  A++ +    LH AA + +E+ + 
Sbjct: 8   ETDGLLPLERQ--LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVR 65

Query: 92  LLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSG 151
           LLL H A V+  D        V A   A  C                 G +AL  +   G
Sbjct: 66  LLLEHEAAVDEEDA-------VGALTEARLC----------------FGMNALLLSAWFG 102

Query: 152 HLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCK--DRKGYGL 209
           HL  + +L+N GA ++   K     LH AA  GH+ VL  ++    D+     D+ G   
Sbjct: 103 HLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTA 162

Query: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPN 269
            H AA  GQ++ + +L+  G + +  +  GNTALH+A   G  AV   LV+ G ++ + N
Sbjct: 163 FHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQN 222

Query: 270 DKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNG 329
            +G T LH AA  ++   C++LL+  G+ VN  +++  S LH AA+ G    S++LI  G
Sbjct: 223 AEGLTALHSAAGGSHPD-CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAG 281

Query: 330 SEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCR 389
              +  D  G +PLH+A R+    L+  L+ + +D          PLHLA    + D   
Sbjct: 282 GCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIA- 340

Query: 390 KLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSS 445
                            + +L AG D+N  D  G+T L  A    +V  +++++ +
Sbjct: 341 -----------------DMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379



 Score =  146 bits (368), Expect = 1e-34
 Identities = 110/370 (29%), Positives = 177/370 (47%), Gaps = 15/370 (4%)

Query: 2   GILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLL 61
           G+L +  Q  L +A    +V  ++ L+ ++ N    +   R  LH AA  G    ++LLL
Sbjct: 11  GLLPLERQ--LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLL 68

Query: 62  MSGANVNAKDTLWLTPLHRAAASRNE----------KVLGLLLAHSADVNARDKLWQTPL 111
              A V+ +D +      R     N           ++L +L+   A ++   K   T L
Sbjct: 69  EHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLL 128

Query: 112 HVAAANRATKCAEALAPLLS--SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVC 169
           H AA          +   L   +L+  D+ GR+A H A   G L+ ++ L+  G   NV 
Sbjct: 129 HCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVK 188

Query: 170 DKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMG 229
           DK+    LH AA  GH+ VL+ LV  G DL  ++ +G   LH+AA     + V+ LLR G
Sbjct: 189 DKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAG 248

Query: 230 AEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCL 289
           + ++       + LH A   G + V+  L++AG   N  + +G +PLH+ AV  N    +
Sbjct: 249 STVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHL-AVRHNFPALV 307

Query: 290 ELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARY 349
            LL+N+ +DVN      ++PLH+AA H     + +L+  G +++  DK G T L VA R 
Sbjct: 308 RLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRS 367

Query: 350 GHELLISTLM 359
            H  L+  ++
Sbjct: 368 NHVSLVDMII 377



 Score =  133 bits (335), Expect = 8e-31
 Identities = 113/380 (29%), Positives = 169/380 (44%), Gaps = 31/380 (8%)

Query: 111 LHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCD 170
           LH AA        + L     +    +  GR ALH A  +GH + V LLL   A+++  D
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78

Query: 171 KKER----------QPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIE 220
                           L  +A+ GHL +L++LV  GA + C+ + G  LLH AA  G + 
Sbjct: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138

Query: 221 VVKYLLR--MGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHV 278
           V+ +++       +D  +  G TA H A   GQ      LV +G + N  + +G T LH+
Sbjct: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198

Query: 279 AAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKF 338
           AA   + A+ L+ LV+ G D+  Q+ EG + LH AA        Q+L++ GS ++   + 
Sbjct: 199 AAGRGHMAV-LQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQK 257

Query: 339 GNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLY 398
             + LH AA  G E +   L+  G            PLHLAV   F    R L++S    
Sbjct: 258 NLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDS-- 315

Query: 399 SIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRT 458
                           D+N  DN  +T LH AA     +  ++LL +G DL  RDK G+T
Sbjct: 316 ----------------DVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKT 359

Query: 459 PLHYAAANGSYQCAVTLVTA 478
            L  A  +        ++ A
Sbjct: 360 ALAVAVRSNHVSLVDMIIKA 379



 Score =  130 bits (327), Expect = 7e-30
 Identities = 111/369 (30%), Positives = 168/369 (45%), Gaps = 22/369 (5%)

Query: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
           LH AA   +   ++ L    VN   R+H GR AL  A   G  + V +L  H A+   ++
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78

Query: 649 RKRKWTP---------LHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNG 699
                T          L  +A  GH   L +L++SG +          G T L  A   G
Sbjct: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCES---KDGLTLLHCAAQKG 135

Query: 700 HVDCVHLLLE--KGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTP 757
           HV  +  ++E  +    D  D  GRTA HR A  G  D L  L+        +D +G T 
Sbjct: 136 HVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTA 195

Query: 758 IHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPF 816
           +HLA+  GH AVL+ L+   L  +  +A     G + +H A+   H DC++LLL   S  
Sbjct: 196 LHLAAGRGHMAVLQRLVDIGLDLEEQNA----EGLTALHSAAGGSHPDCVQLLLRAGSTV 251

Query: 817 SYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRM 876
           + L     + LH A ++  +  + +L+ A G    N  D +G +PLH A   +  + +R+
Sbjct: 252 NALTQKNLSCLHYAALSGSEDVSRVLIHAGGC--ANVVDHQGASPLHLAVRHNFPALVRL 309

Query: 877 LLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKG 936
           L+   ++VNA D+  +T L  AAE+      + LL  G  DL + D+   TAL +A    
Sbjct: 310 LINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAG-VDLNLRDKQGKTALAVAVRSN 368

Query: 937 HEKCALMIL 945
           H     MI+
Sbjct: 369 HVSLVDMII 377



 Score =  119 bits (299), Expect = 1e-26
 Identities = 118/422 (27%), Positives = 173/422 (40%), Gaps = 64/422 (15%)

Query: 427 LHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEAD 486
           LH AA   NV  +  L+    + R R+  GR  LH+AA  G  Q    L+   A V+E D
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78

Query: 487 CKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLR 546
             G                                      EA  C              
Sbjct: 79  AVGALT-----------------------------------EARLCF------------- 90

Query: 547 DRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAE 606
              G  A+  +A +G+ + L++L+          ES   ++ LH AA  GH   L  + E
Sbjct: 91  ---GMNALLLSAWFGHLRILQILVNSGAKI--HCESKDGLTLLHCAAQKGHVPVLAFIME 145

Query: 607 TL--VNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGH 664
            L  V LD  D  GRTA   A E G  + ++ L   G    +K+++   T LH AA  GH
Sbjct: 146 DLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGN-TALHLAAGRGH 204

Query: 665 TDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTA 724
              L  L+D G   D+ +  +A G T L  A    H DCV LLL  GST +A   +  + 
Sbjct: 205 MAVLQRLVDIG--LDLEE-QNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSC 261

Query: 725 LHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLD 784
           LH  A++G ED    L+         D +G +P+HLA      A++R L    +++D   
Sbjct: 262 LHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLL----INSDSDV 317

Query: 785 AGVDYSGYSPMHWASYTGHEDCLE-LLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLL 843
             VD    +P+H A+    +D  + LL+     +  +    T L  AV +N  S  +M++
Sbjct: 318 NAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377

Query: 844 GA 845
            A
Sbjct: 378 KA 379



 Score =  113 bits (283), Expect = 8e-25
 Identities = 117/456 (25%), Positives = 179/456 (39%), Gaps = 81/456 (17%)

Query: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPN 269
           LH AA    +  ++ L+         N  G  ALH A   G +     L+   A V++ +
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78

Query: 270 DKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNG 329
             G          T   LC                 G + L ++A  G     QIL+ +G
Sbjct: 79  AVG--------ALTEARLCF----------------GMNALLLSAWFGHLRILQILVNSG 114

Query: 330 SEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCR 389
           ++I C  K G T LH AA+ GH  +++ +M +  D A   +  +                
Sbjct: 115 AKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLG----------RTAFH 164

Query: 390 KLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADL 449
           +    GQL ++      + ++ +G D N  D  G T LH AA  G++  L  L+  G DL
Sbjct: 165 RAAEHGQLDAL------DFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDL 218

Query: 450 RRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHT 509
             ++  G T LH AA      C   L+ AG+ VN    K  S LHYAA S          
Sbjct: 219 EEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALS---------- 268

Query: 510 PSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELL 569
             S D                     L+  G   ++ D QG + +H A     R N   L
Sbjct: 269 -GSEDVS-----------------RVLIHAGGCANVVDHQGASPLHLAV----RHNFPAL 306

Query: 570 LEMSFNCLEDVES--TIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATE 627
           + +  N   DV +      +PLHLAA +   +    L    V+L++RD +G+TAL +A  
Sbjct: 307 VRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVR 366

Query: 628 RGSTECVEVLTAHGASALIKERKRKWTPLHAAAASG 663
                 V+++       +  +R  +W   H +  SG
Sbjct: 367 SNHVSLVDMI-------IKADRFYRWEKDHPSDPSG 395



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 104/374 (27%), Positives = 161/374 (43%), Gaps = 29/374 (7%)

Query: 656  LHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTAD 715
            LH AA   +   +  LI  G R + T   +  G+  L  A   GH   V LLLE  +  D
Sbjct: 19   LHEAARQNNVGRMQELI--GRRVN-TRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVD 75

Query: 716  AADLRGR----------TALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACG 765
              D  G            AL   A  G    L  L++  A + C    G T +H A+  G
Sbjct: 76   EEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKG 135

Query: 766  HTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLL----EHSPFSYLEG 821
            H  VL  +++  L    LD  VD  G +  H A+  G  D L+ L+    +H+     EG
Sbjct: 136  HVPVLAFIMED-LEDVALDH-VDKLGRTAFHRAAEHGQLDALDFLVGSGCDHN-VKDKEG 192

Query: 822  NPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQ 881
            N  T LH A      +  + L+  +G  +   ++A+G T LH+AA   +   +++LL+  
Sbjct: 193  N--TALHLAAGRGHMAVLQRLVD-IGLDL-EEQNAEGLTALHSAAGGSHPDCVQLLLRAG 248

Query: 882  AEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCA 941
            + VNA      + L  AA +G       L++ G     V+D    + LHLA         
Sbjct: 249  STVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGC-ANVVDHQGASPLHLAVRHNFPALV 307

Query: 942  LMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALAC 1001
             +++    D   +NA ++  Q PLH+AA +    +   LL  G  +   D++G T ALA 
Sbjct: 308  RLLINSDSD---VNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKT-ALAV 363

Query: 1002 APNKDVADCLALIL 1015
            A   +    + +I+
Sbjct: 364  AVRSNHVSLVDMII 377


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score =  146 bits (369), Expect = 9e-35
 Identities = 115/391 (29%), Positives = 191/391 (48%), Gaps = 7/391 (1%)

Query: 8   DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67
           D   L +A    DV  VR LL +  ++N   +E  + L  A   G   + Q+LL   ANV
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264

Query: 68  NAKDTLW-LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126
             +     +TPL  A++     ++ LLL H ADVN++     T L  A A       + L
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324

Query: 127 APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP-LHWAAFLGH 185
               +++   + +G + L  A  +GH+E   +LL+ GA +N    + ++  L  A + GH
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384

Query: 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245
           L++++ L+  GAD   K  + +  L  A   G +EV + LL  GA+++ P     + L +
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 444

Query: 246 ACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKE 305
           A   G   +A  L+  GAN+ + ND+G+TPL  AA   +  + + LL+  GA++N Q++E
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEE 503

Query: 306 GKSPLHMAAIHGRFTR-SQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD 364
            +      A  G F+  +  LI+ G++I+      +TPL  A++ GH  L+  L+ +GA+
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELG---CSTPLMEASQEGHLELVKYLLASGAN 560

Query: 365 TARRGIHDMFPLHLAVLFGFSDCCRKLLSSG 395
                      L  A   G +D    LL +G
Sbjct: 561 VHATTATGDTALTYACENGHTDVADVLLQAG 591



 Score =  137 bits (345), Expect = 5e-32
 Identities = 123/415 (29%), Positives = 198/415 (47%), Gaps = 31/415 (7%)

Query: 78  LHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVAD 137
           L  A +  +   +  LL     VN   +  ++ L +A +    + A+ L  L    NV D
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVL--LAMHANVED 266

Query: 138 RSGR---SALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVA 194
           R  +   + L  A   G+L+ V LLL   A +N         L +A   G ++++K+L+ 
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326

Query: 195 RGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEID-EPNAFGNTALHIACYLGQDA 253
            GA++   +  G+  L  AA++G +EV + LL  GA I+   N F  +AL +ACY G   
Sbjct: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386

Query: 254 VAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMA 313
           +   L+ AGA+     D+  T L  A +  +  +   LL+++GA VN  +   +SPL +A
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESPLTLA 445

Query: 314 AIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD-TARRGIHD 372
           A  G    + +LI+ G+ ++  +  G TPL  AAR GHE +++ L+  GA+  A+     
Sbjct: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505

Query: 373 MFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLG-RTCLHAAA 431
              L LA   GFS+                    + ++ AG DI     LG  T L  A+
Sbjct: 506 ETALTLACCGGFSEVA------------------DFLIKAGADIE----LGCSTPLMEAS 543

Query: 432 SGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEAD 486
             G++E +  LL+SGA++      G T L YA  NG    A  L+ AGA +++ +
Sbjct: 544 QEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 598



 Score =  126 bits (317), Expect = 1e-28
 Identities = 127/437 (29%), Positives = 201/437 (45%), Gaps = 22/437 (5%)

Query: 493 LHYAAASDTYRRAEPHTPSSHDAEEDEP--LKESRRKEAFFCLEFLLDNGADPSLRDRQG 550
           L  AAA+ T  +AE    +SH+A + +   L E+        +  LLD G   +    +G
Sbjct: 183 LDEAAAALTRMKAE----NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG 238

Query: 551 YTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVN 610
            + +  A + G  +  ++LL M  N +ED  +   ++PL  A+  G+ + +K L     +
Sbjct: 239 ESLLCLACSAGYYELAQVLLAMHAN-VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 297

Query: 611 LDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHL 670
           ++ +   G TAL  A   G  + V+VL   GA+ +    +   TPL  AA++GH +   +
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGAN-IEDHNENGHTPLMEAASAGHVEVARV 356

Query: 671 LIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAV 730
           L+D G  A I    + + ++ L LA   GH+D V  LLE G+  +       TAL    +
Sbjct: 357 LLDHG--AGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414

Query: 731 TGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYS 790
            G  +    LLD  A V        +P+ LA+  GH  +   L++   + +     V+  
Sbjct: 415 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE----VNDE 470

Query: 791 GYSPMHWASYTGHEDCLELLLEHSPF--SYLEGNPFTPLHCAVINNQDSTTEMLLGALGA 848
           GY+P+  A+  GHE+ + LLL       +  E    T L  A         + L+ A GA
Sbjct: 471 GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA-GA 529

Query: 849 KIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVE 908
            I    +    TPL  A+   ++  ++ LL   A V+AT  TG TAL  A ENG T   +
Sbjct: 530 DI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 585

Query: 909 FLLYRGKADLTVLDENK 925
            LL  G ADL   ++ K
Sbjct: 586 VLLQAG-ADLDKQEDMK 601



 Score =  122 bits (307), Expect = 1e-27
 Identities = 143/566 (25%), Positives = 219/566 (38%), Gaps = 103/566 (18%)

Query: 187 EVLKLLVARGADLGCKDRKGYGLLHT---AAASGQIEVVKYLLRMGAEIDEPNAFGNTAL 243
           E+     A GADL   D +    L     AA  G++         G    +P        
Sbjct: 123 EIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTAD-----GKAFADPEVLRRLTS 177

Query: 244 HIACYLGQDAVAIELVNA--GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY 301
            ++C L + A A+  + A    N  Q + +        A S      +  L++ G  VN 
Sbjct: 178 SVSCALDEAAAALTRMKAENSHNAGQVDTRSLAE----ACSDGDVNAVRKLLDEGRSVNE 233

Query: 302 QSKEGKSPLHMAAIHGRFTRSQILIQNGSEI-DCADKFGNTPLHVAARYGHELLISTLMT 360
            ++EG+S L +A   G +  +Q+L+   + + D  +K   TPL  A+  G+  ++  L+ 
Sbjct: 234 HTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL- 292

Query: 361 NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPD 420
                    +HD                                          D+N+  
Sbjct: 293 ---------LHDA-----------------------------------------DVNSQS 302

Query: 421 NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480
             G T L  A +GG V+ + +LL+ GA++   ++ G TPL  AA+ G  + A  L+  GA
Sbjct: 303 ATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362

Query: 481 GVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAE-EDEPLKESRRKEAFFCLEFLLDN 539
           G+N                            +H  E ++  L  +  K     + FLL+ 
Sbjct: 363 GIN----------------------------THSNEFKESALTLACYKGHLDMVRFLLEA 394

Query: 540 GADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCE 599
           GAD   +  + +TA+  A   G+ +   LLL+         +S    SPL LAA  GH E
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF--ESPLTLAACGGHVE 452

Query: 600 ALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAA 659
               L E   NL+  + +G T L  A   G  E V +L A GA+   +  + + T L  A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 660 AASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADL 719
              G ++    LI +G  ADI    +    TPLM A   GH++ V  LL  G+   A   
Sbjct: 513 CCGGFSEVADFLIKAG--ADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTA 566

Query: 720 RGRTALHRGAVTGCEDCLAALLDHDA 745
            G TAL      G  D    LL   A
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGA 592



 Score =  110 bits (274), Expect = 9e-24
 Identities = 88/264 (33%), Positives = 127/264 (48%), Gaps = 9/264 (3%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQE-RRTPLHAAAYVGDVPILQLLLMSGANVNA 69
           PL++A  +  VE  R LL     IN    E + + L  A Y G + +++ LL +GA+   
Sbjct: 341 PLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 400

Query: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
           K     T L  A    + +V  LLL   A VN     +++PL +AA     + A  L   
Sbjct: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460

Query: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV-CDKKERQPLHWAAFLGHLEV 188
            ++L   +  G + L  A   GH E V LLL +GA++N   ++ +   L  A   G  EV
Sbjct: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520

Query: 189 LKLLVARGAD--LGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246
              L+  GAD  LGC        L  A+  G +E+VKYLL  GA +    A G+TAL  A
Sbjct: 521 ADFLIKAGADIELGCSTP-----LMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 575

Query: 247 CYLGQDAVAIELVNAGANVNQPND 270
           C  G   VA  L+ AGA++++  D
Sbjct: 576 CENGHTDVADVLLQAGADLDKQED 599



 Score =  105 bits (262), Expect = 2e-22
 Identities = 116/423 (27%), Positives = 172/423 (40%), Gaps = 50/423 (11%)

Query: 592  AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651
            A  +G   A++ L +   +++    +G + L LA   G  E  +VL A            
Sbjct: 212  ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA------------ 259

Query: 652  KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711
                +HA              D G + DIT         PLM A   G++D V LLL   
Sbjct: 260  ----MHANVE-----------DRGNKGDIT---------PLMAASSGGYLDIVKLLLLHD 295

Query: 712  STADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLR 771
            +  ++    G TAL      G  D +  LL+  A +   +  G TP+  A++ GH  V R
Sbjct: 296  ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355

Query: 772  TLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCA 830
             LL        ++   +    S +  A Y GH D +  LLE  +   +      T L  A
Sbjct: 356  VLLDHGAG---INTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEA 412

Query: 831  VINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT 890
             ++       +LL + GA+ VN       +PL  AA   +V    +L++  A +   +  
Sbjct: 413  CMDGHVEVARLLLDS-GAQ-VNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE 470

Query: 891  GRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQD 950
            G T LM AA  G    V  LL +G       +E + TAL LAC  G  + A  ++    D
Sbjct: 471  GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 530

Query: 951  LGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPN--KDVA 1008
            + L  +T      PL  A++ G   +V+ LL+ GA V A    G T       N   DVA
Sbjct: 531  IELGCST------PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 584

Query: 1009 DCL 1011
            D L
Sbjct: 585  DVL 587



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 77/291 (26%), Positives = 111/291 (38%), Gaps = 41/291 (14%)

Query: 760  LASAC--GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFS 817
            LA AC  G    +R LL    S +         G S +  A   G+ +  ++LL      
Sbjct: 209  LAEACSDGDVNAVRKLLDEGRSVNEHTE----EGESLLCLACSAGYYELAQVLLAMHANV 264

Query: 818  YLEGNP--FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLR 875
               GN    TPL  A         ++LL  L    VNS+ A G T L  A     V  ++
Sbjct: 265  EDRGNKGDITPLMAASSGGYLDIVKLLL--LHDADVNSQSATGNTALTYACAGGFVDIVK 322

Query: 876  MLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSK 935
            +LL   A +   +  G T LM AA  G       LL  G    T  +E K +AL LAC K
Sbjct: 323  VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382

Query: 936  GHEKCALMILAETQDL------------------------------GLINATNSALQMPL 965
            GH      +L    D                                 +N    + + PL
Sbjct: 383  GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 442

Query: 966  HIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILS 1016
             +AA  G   +   L+  GA +  V++EG+TP +  A  +   + +AL+L+
Sbjct: 443  TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA-REGHEEMVALLLA 492



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 55/177 (31%), Positives = 82/177 (46%), Gaps = 4/177 (2%)

Query: 851  VNSRDAKGR-TPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 909
            V  R  KG  TPL AA+    +  +++LL H A+VN+   TG TAL  A   G    V+ 
Sbjct: 264  VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323

Query: 910  LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969
            LL  G A++   +EN +T L  A S GH + A ++L      G+   +N   +  L +A 
Sbjct: 324  LLNEG-ANIEDHNENGHTPLMEAASAGHVEVARVLL--DHGAGINTHSNEFKESALTLAC 380

Query: 970  RNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFPPKDA 1026
              G   +V+ LL  GA      +E HT  +    +  V     L+ S  +   P D+
Sbjct: 381  YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 33/127 (25%), Positives = 52/127 (40%), Gaps = 31/127 (24%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERR---------------------------- 42
           PL++A      E V  LL+Q  NIN   +E +                            
Sbjct: 474 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 533

Query: 43  ---TPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSAD 99
              TPL  A+  G + +++ LL SGANV+A      T L  A  + +  V  +LL   AD
Sbjct: 534 GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593

Query: 100 VNARDKL 106
           ++ ++ +
Sbjct: 594 LDKQEDM 600


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score =  146 bits (369), Expect = 9e-35
 Identities = 115/391 (29%), Positives = 191/391 (48%), Gaps = 7/391 (1%)

Query: 8   DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67
           D   L +A    DV  VR LL +  ++N   +E  + L  A   G   + Q+LL   ANV
Sbjct: 194 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 253

Query: 68  NAKDTLW-LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126
             +     +TPL  A++     ++ LLL H ADVN++     T L  A A       + L
Sbjct: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313

Query: 127 APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP-LHWAAFLGH 185
               +++   + +G + L  A  +GH+E   +LL+ GA +N    + ++  L  A + GH
Sbjct: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 373

Query: 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245
           L++++ L+  GAD   K  + +  L  A   G +EV + LL  GA+++ P     + L +
Sbjct: 374 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 433

Query: 246 ACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKE 305
           A   G   +A  L+  GAN+ + ND+G+TPL  AA   +  + + LL+  GA++N Q++E
Sbjct: 434 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEE 492

Query: 306 GKSPLHMAAIHGRFTR-SQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD 364
            +      A  G F+  +  LI+ G++I+      +TPL  A++ GH  L+  L+ +GA+
Sbjct: 493 TQETALTLACCGGFSEVADFLIKAGADIELG---CSTPLMEASQEGHLELVKYLLASGAN 549

Query: 365 TARRGIHDMFPLHLAVLFGFSDCCRKLLSSG 395
                      L  A   G +D    LL +G
Sbjct: 550 VHATTATGDTALTYACENGHTDVADVLLQAG 580



 Score =  139 bits (350), Expect = 1e-32
 Identities = 140/506 (27%), Positives = 226/506 (44%), Gaps = 50/506 (9%)

Query: 6   ITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHA---AAYVGDVPILQLLL- 61
           I DQ  L   +     E   S  ++  ++  +D E +  L A   AA   D  +L+ L  
Sbjct: 107 ILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTS 166

Query: 62  ---------------MSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKL 106
                          M   N +    +    L  A +  +   +  LL     VN   + 
Sbjct: 167 SVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEE 226

Query: 107 WQTPLHVAAANRATKCAEALAPLLSSLNVADRSGR---SALHHAVHSGHLETVNLLLNKG 163
            ++ L +A +    + A+ L  L    NV DR  +   + L  A   G+L+ V LLL   
Sbjct: 227 GESLLCLACSAGYYELAQVL--LAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHD 284

Query: 164 ASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVK 223
           A +N         L +A   G ++++K+L+  GA++   +  G+  L  AA++G +EV +
Sbjct: 285 ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 344

Query: 224 YLLRMGAEID-EPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVS 282
            LL  GA I+   N F  +AL +ACY G   +   L+ AGA+     D+  T L  A + 
Sbjct: 345 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 404

Query: 283 TNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTP 342
            +  +   LL+++GA VN  +   +SPL +AA  G    + +LI+ G+ ++  +  G TP
Sbjct: 405 GHVEVA-RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 463

Query: 343 LHVAARYGHELLISTLMTNGAD-TARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIV 401
           L  AAR GHE +++ L+  GA+  A+        L LA   GFS+               
Sbjct: 464 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA------------- 510

Query: 402 SSLSNEHVLSAGFDINTPDNLG-RTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPL 460
                + ++ AG DI     LG  T L  A+  G++E +  LL+SGA++      G T L
Sbjct: 511 -----DFLIKAGADIE----LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561

Query: 461 HYAAANGSYQCAVTLVTAGAGVNEAD 486
            YA  NG    A  L+ AGA +++ +
Sbjct: 562 TYACENGHTDVADVLLQAGADLDKQE 587



 Score =  128 bits (321), Expect = 3e-29
 Identities = 132/484 (27%), Positives = 213/484 (44%), Gaps = 25/484 (5%)

Query: 444 SSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYR 503
           + GADLR  D   +  L       ++     L    + V+ A  +  + L    A +++ 
Sbjct: 130 AEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHN 189

Query: 504 RAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNR 563
             +  T S  +A  D  +   R+         LLD G   +    +G + +  A + G  
Sbjct: 190 AGQVDTRSLAEACSDGDVNAVRK---------LLDEGRSVNEHTEEGESLLCLACSAGYY 240

Query: 564 QNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALF 623
           +  ++LL M  N +ED  +   ++PL  A+  G+ + +K L     +++ +   G TAL 
Sbjct: 241 ELAQVLLAMHAN-VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALT 299

Query: 624 LATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDV 683
            A   G  + V+VL   GA+ +    +   TPL  AA++GH +   +L+D G  A I   
Sbjct: 300 YACAGGFVDIVKVLLNEGAN-IEDHNENGHTPLMEAASAGHVEVARVLLDHG--AGINTH 356

Query: 684 MDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDH 743
            + + ++ L LA   GH+D V  LLE G+  +       TAL    + G  +    LLD 
Sbjct: 357 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS 416

Query: 744 DAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGH 803
            A V        +P+ LA+  GH  +   L++   + +     V+  GY+P+  A+  GH
Sbjct: 417 GAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE----VNDEGYTPLMEAAREGH 472

Query: 804 EDCLELLLEHSPF--SYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTP 861
           E+ + LLL       +  E    T L  A         + L+ A GA I    +    TP
Sbjct: 473 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA-GADI----ELGCSTP 527

Query: 862 LHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVL 921
           L  A+   ++  ++ LL   A V+AT  TG TAL  A ENG T   + LL  G ADL   
Sbjct: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG-ADLDKQ 586

Query: 922 DENK 925
           ++ K
Sbjct: 587 EDMK 590



 Score =  119 bits (298), Expect = 2e-26
 Identities = 141/563 (25%), Positives = 215/563 (38%), Gaps = 108/563 (19%)

Query: 187 EVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246
           E+     A GADL   D +    L               L   A   +P         ++
Sbjct: 123 EIFLSSTAEGADLRTVDPETQARLEA-------------LLEAAAFADPEVLRRLTSSVS 169

Query: 247 CYLGQDAVAIELVNA--GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSK 304
           C L + A A+  + A    N  Q + +        A S      +  L++ G  VN  ++
Sbjct: 170 CALDEAAAALTRMKAENSHNAGQVDTRSLAE----ACSDGDVNAVRKLLDEGRSVNEHTE 225

Query: 305 EGKSPLHMAAIHGRFTRSQILIQNGSEI-DCADKFGNTPLHVAARYGHELLISTLMTNGA 363
           EG+S L +A   G +  +Q+L+   + + D  +K   TPL  A+  G+  ++  L+    
Sbjct: 226 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL---- 281

Query: 364 DTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLG 423
                 +HD                                          D+N+    G
Sbjct: 282 ------LHDA-----------------------------------------DVNSQSATG 294

Query: 424 RTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVN 483
            T L  A +GG V+ + +LL+ GA++   ++ G TPL  AA+ G  + A  L+  GAG+N
Sbjct: 295 NTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN 354

Query: 484 EADCKGCSPLHYAAASDTYRRAEPHTPSSHDAE-EDEPLKESRRKEAFFCLEFLLDNGAD 542
                                       +H  E ++  L  +  K     + FLL+ GAD
Sbjct: 355 ----------------------------THSNEFKESALTLACYKGHLDMVRFLLEAGAD 386

Query: 543 PSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALK 602
              +  + +TA+  A   G+ +   LLL+         +S    SPL LAA  GH E   
Sbjct: 387 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF--ESPLTLAACGGHVELAA 444

Query: 603 TLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS 662
            L E   NL+  + +G T L  A   G  E V +L A GA+   +  + + T L  A   
Sbjct: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504

Query: 663 GHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGR 722
           G ++    LI +G  ADI    +    TPLM A   GH++ V  LL  G+   A    G 
Sbjct: 505 GFSEVADFLIKAG--ADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGD 558

Query: 723 TALHRGAVTGCEDCLAALLDHDA 745
           TAL      G  D    LL   A
Sbjct: 559 TALTYACENGHTDVADVLLQAGA 581



 Score =  110 bits (274), Expect = 9e-24
 Identities = 88/264 (33%), Positives = 127/264 (48%), Gaps = 9/264 (3%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQE-RRTPLHAAAYVGDVPILQLLLMSGANVNA 69
           PL++A  +  VE  R LL     IN    E + + L  A Y G + +++ LL +GA+   
Sbjct: 330 PLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 389

Query: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
           K     T L  A    + +V  LLL   A VN     +++PL +AA     + A  L   
Sbjct: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449

Query: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV-CDKKERQPLHWAAFLGHLEV 188
            ++L   +  G + L  A   GH E V LLL +GA++N   ++ +   L  A   G  EV
Sbjct: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 509

Query: 189 LKLLVARGAD--LGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246
              L+  GAD  LGC        L  A+  G +E+VKYLL  GA +    A G+TAL  A
Sbjct: 510 ADFLIKAGADIELGCSTP-----LMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 564

Query: 247 CYLGQDAVAIELVNAGANVNQPND 270
           C  G   VA  L+ AGA++++  D
Sbjct: 565 CENGHTDVADVLLQAGADLDKQED 588



 Score =  105 bits (262), Expect = 2e-22
 Identities = 116/423 (27%), Positives = 172/423 (40%), Gaps = 50/423 (11%)

Query: 592  AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651
            A  +G   A++ L +   +++    +G + L LA   G  E  +VL A            
Sbjct: 201  ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA------------ 248

Query: 652  KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711
                +HA              D G + DIT         PLM A   G++D V LLL   
Sbjct: 249  ----MHANVE-----------DRGNKGDIT---------PLMAASSGGYLDIVKLLLLHD 284

Query: 712  STADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLR 771
            +  ++    G TAL      G  D +  LL+  A +   +  G TP+  A++ GH  V R
Sbjct: 285  ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 344

Query: 772  TLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCA 830
             LL        ++   +    S +  A Y GH D +  LLE  +   +      T L  A
Sbjct: 345  VLLDHGAG---INTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEA 401

Query: 831  VINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT 890
             ++       +LL + GA+ VN       +PL  AA   +V    +L++  A +   +  
Sbjct: 402  CMDGHVEVARLLLDS-GAQ-VNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE 459

Query: 891  GRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQD 950
            G T LM AA  G    V  LL +G       +E + TAL LAC  G  + A  ++    D
Sbjct: 460  GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 519

Query: 951  LGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPN--KDVA 1008
            + L  +T      PL  A++ G   +V+ LL+ GA V A    G T       N   DVA
Sbjct: 520  IELGCST------PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 573

Query: 1009 DCL 1011
            D L
Sbjct: 574  DVL 576



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 77/291 (26%), Positives = 111/291 (38%), Gaps = 41/291 (14%)

Query: 760  LASAC--GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFS 817
            LA AC  G    +R LL    S +         G S +  A   G+ +  ++LL      
Sbjct: 198  LAEACSDGDVNAVRKLLDEGRSVNEHTE----EGESLLCLACSAGYYELAQVLLAMHANV 253

Query: 818  YLEGNP--FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLR 875
               GN    TPL  A         ++LL  L    VNS+ A G T L  A     V  ++
Sbjct: 254  EDRGNKGDITPLMAASSGGYLDIVKLLL--LHDADVNSQSATGNTALTYACAGGFVDIVK 311

Query: 876  MLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSK 935
            +LL   A +   +  G T LM AA  G       LL  G    T  +E K +AL LAC K
Sbjct: 312  VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 371

Query: 936  GHEKCALMILAETQDL------------------------------GLINATNSALQMPL 965
            GH      +L    D                                 +N    + + PL
Sbjct: 372  GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 431

Query: 966  HIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILS 1016
             +AA  G   +   L+  GA +  V++EG+TP +  A  +   + +AL+L+
Sbjct: 432  TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA-REGHEEMVALLLA 481



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 55/177 (31%), Positives = 82/177 (46%), Gaps = 4/177 (2%)

Query: 851  VNSRDAKGR-TPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 909
            V  R  KG  TPL AA+    +  +++LL H A+VN+   TG TAL  A   G    V+ 
Sbjct: 253  VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 312

Query: 910  LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969
            LL  G A++   +EN +T L  A S GH + A ++L      G+   +N   +  L +A 
Sbjct: 313  LLNEG-ANIEDHNENGHTPLMEAASAGHVEVARVLL--DHGAGINTHSNEFKESALTLAC 369

Query: 970  RNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFPPKDA 1026
              G   +V+ LL  GA      +E HT  +    +  V     L+ S  +   P D+
Sbjct: 370  YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 426



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 33/127 (25%), Positives = 52/127 (40%), Gaps = 31/127 (24%)

Query: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERR---------------------------- 42
           PL++A      E V  LL+Q  NIN   +E +                            
Sbjct: 463 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 522

Query: 43  ---TPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSAD 99
              TPL  A+  G + +++ LL SGANV+A      T L  A  + +  V  +LL   AD
Sbjct: 523 GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 582

Query: 100 VNARDKL 106
           ++ ++ +
Sbjct: 583 LDKQEDM 589


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  141 bits (356), Expect = 3e-33
 Identities = 108/348 (31%), Positives = 174/348 (50%), Gaps = 6/348 (1%)

Query: 25  RSLLSQKENINVLDQERRTPLHAAAYV---GDVPILQLLL--MSGANVNAKDTLWLTPLH 79
           RS +S   + + LD+E    + A  +     +VP LQ LL  +S  +VN  +     PL 
Sbjct: 325 RSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLL 384

Query: 80  RAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS 139
            AA   N ++L LL+   + ++ +DK     ++ AA +      + L+     L+V D+S
Sbjct: 385 IAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKS 444

Query: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199
           G  ALH A   GH +   LL + G++ N+ DK+E  PLH AA+ G+  V K L   G ++
Sbjct: 445 GEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNV 504

Query: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV 259
             K+R+G   L TA+A G  ++V+ L   GA+++  +  G+ ALH+A    Q  V   L+
Sbjct: 505 NIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLL 564

Query: 260 NAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRF 319
           + G  V+  +  G TPLHVA    N  + + L   N  +++  +K G++PLH+AA +G  
Sbjct: 565 SQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEAN-CNLDISNKYGRTPLHLAANNGIL 623

Query: 320 TRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTAR 367
              + L   G+ ++     G T   +A    HE +   L     DT R
Sbjct: 624 DVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHR 671



 Score =  137 bits (346), Expect = 4e-32
 Identities = 93/305 (30%), Positives = 151/305 (49%), Gaps = 5/305 (1%)

Query: 12  LVQAIFSRDVEEVRSLLSQKEN--INVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNA 69
           ++ AI   +V  ++ LL    N  +N  ++    PL  AA  G++ ILQLL+  G+ ++ 
Sbjct: 348 IIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDV 407

Query: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
           +D      ++ AA   +   L  L  +   ++ +DK  +  LHVAA       A+ L   
Sbjct: 408 QDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSF 467

Query: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL 189
            S+ N+ D+   + LH A   G+      L   G ++N+ +++   PL  A+  G+ +++
Sbjct: 468 GSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIV 527

Query: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYL 249
           + L   GADL   D+ G+  LH A    Q+EV+K LL  G  +D  +  GNT LH+AC  
Sbjct: 528 ECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKD 587

Query: 250 GQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGAL-CLELLVNNGADVNYQSKEGKS 308
           G   + + L  A  N++  N  G TPLH+AA   NG L  +  L   GA V   + +GK+
Sbjct: 588 GNMPIVVALCEANCNLDISNKYGRTPLHLAA--NNGILDVVRYLCLMGASVEALTTDGKT 645

Query: 309 PLHMA 313
              +A
Sbjct: 646 AEDLA 650



 Score =  129 bits (325), Expect = 1e-29
 Identities = 91/301 (30%), Positives = 141/301 (46%), Gaps = 12/301 (3%)

Query: 133 LNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLL 192
           +N  ++ G   L  A   G+++ + LL+ +G+ ++V DK     ++WAA  GH++ LK L
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431

Query: 193 VARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQD 252
                 L  KD+ G   LH AA  G  +V + L   G+  +  +    T LH A + G  
Sbjct: 432 SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYY 491

Query: 253 AVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHM 312
           +VA  L  AG NVN  N +G TPL  A+      + +E L  +GAD+N   K+G   LH+
Sbjct: 492 SVAKALCEAGCNVNIKNREGETPLLTASARGYHDI-VECLAEHGADLNACDKDGHIALHL 550

Query: 313 AAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHD 372
           A    +    + L+  G  +D  D+ GNTPLHVA + G+  ++  L     +      + 
Sbjct: 551 AVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYG 610

Query: 373 MFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAAS 432
             PLHLA   G  D  R L   G     +++           D  T ++L R+  H   +
Sbjct: 611 RTPLHLAANNGILDVVRYLCLMGASVEALTT-----------DGKTAEDLARSEQHEHVA 659

Query: 433 G 433
           G
Sbjct: 660 G 660



 Score =  119 bits (297), Expect = 2e-26
 Identities = 79/249 (31%), Positives = 119/249 (47%), Gaps = 16/249 (6%)

Query: 264 NVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQ 323
           +VNQPN  G  PL +AA   N  + L+LL+  G+ ++ Q K G + ++ AA HG     +
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQI-LQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLK 429

Query: 324 ILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFG 383
            L +N   +D  DK G   LHVAARYGH  +   L + G++   +   +  PLH A   G
Sbjct: 430 FLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHG 489

Query: 384 FSDCCRKLLSSGQLYSIVSSLSNEHVLSA---------------GFDINTPDNLGRTCLH 428
           +    + L  +G   +I +      +L+A               G D+N  D  G   LH
Sbjct: 490 YYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALH 549

Query: 429 AAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCK 488
            A     +E +  LLS G  +  +D+ G TPLH A  +G+    V L  A   ++ ++  
Sbjct: 550 LAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKY 609

Query: 489 GCSPLHYAA 497
           G +PLH AA
Sbjct: 610 GRTPLHLAA 618



 Score =  113 bits (282), Expect = 1e-24
 Identities = 82/265 (30%), Positives = 126/265 (47%)

Query: 10  PPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNA 69
           PPL+ A    +++ ++ L+ +   I+V D+     ++ AA  G V  L+ L  +   ++ 
Sbjct: 381 PPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDV 440

Query: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
           KD      LH AA   +  V  LL +  ++ N +DK  +TPLH AA +     A+AL   
Sbjct: 441 KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA 500

Query: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL 189
             ++N+ +R G + L  A   G+ + V  L   GA LN CDK     LH A     +EV+
Sbjct: 501 GCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVI 560

Query: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYL 249
           K L+++G  +  +DR G   LH A   G + +V  L      +D  N +G T LH+A   
Sbjct: 561 KTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANN 620

Query: 250 GQDAVAIELVNAGANVNQPNDKGFT 274
           G   V   L   GA+V      G T
Sbjct: 621 GILDVVRYLCLMGASVEALTTDGKT 645



 Score =  112 bits (280), Expect = 2e-24
 Identities = 104/380 (27%), Positives = 160/380 (42%), Gaps = 36/380 (9%)

Query: 403 SLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSS--GADLRRRDKFGRTPL 460
           S SN  V  +   ++  D+     +  A +  NV  L  LL S    D+ + +K G  PL
Sbjct: 324 SRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPL 383

Query: 461 HYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEP 520
             AA  G+ Q    L+  G+ ++  D  G + +++AA     R     T           
Sbjct: 384 LIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAA-----RHGHVDT----------- 427

Query: 521 LKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDV 580
                       L+FL +N     ++D+ G  A+H AA YG+    +LL   SF    ++
Sbjct: 428 ------------LKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLC--SFGSNPNI 473

Query: 581 ESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAH 640
           +     +PLH AA++G+    K L E   N+++++ +G T L  A+ RG  + VE L  H
Sbjct: 474 QDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEH 533

Query: 641 GASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGH 700
           GA     + K     LH A      + +  L+  G      D  D +G TPL +A  +G+
Sbjct: 534 GADLNACD-KDGHIALHLAVRRCQMEVIKTLLSQG---CFVDYQDRHGNTPLHVACKDGN 589

Query: 701 VDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHL 760
           +  V  L E     D ++  GRT LH  A  G  D +  L    A V      G+T   L
Sbjct: 590 MPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDL 649

Query: 761 ASACGHTAVLRTLLQAALST 780
           A +  H  V   L +    T
Sbjct: 650 ARSEQHEHVAGLLARLRKDT 669



 Score =  112 bits (279), Expect = 2e-24
 Identities = 101/346 (29%), Positives = 142/346 (41%), Gaps = 81/346 (23%)

Query: 298 DVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLIST 357
           DVN  +K G  PL +AA  G     Q+LI+ GS ID  DK G+  ++ AAR+GH   + T
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGH---VDT 427

Query: 358 LMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDIN 417
           L                               K LS  +                   ++
Sbjct: 428 L-------------------------------KFLSENKC-----------------PLD 439

Query: 418 TPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVT 477
             D  G   LH AA  G+ +   LL S G++   +DK   TPLH AA +G Y  A  L  
Sbjct: 440 VKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCE 499

Query: 478 AGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLL 537
           AG  VN  + +G +PL  A+A              HD                  +E L 
Sbjct: 500 AGCNVNIKNREGETPLLTASAR-----------GYHD-----------------IVECLA 531

Query: 538 DNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGH 597
           ++GAD +  D+ G+ A+H A      + ++ LL  S  C  D +     +PLH+A  +G+
Sbjct: 532 EHGADLNACDKDGHIALHLAVRRCQMEVIKTLL--SQGCFVDYQDRHGNTPLHVACKDGN 589

Query: 598 CEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGAS 643
              +  L E   NLD+ +  GRT L LA   G  + V  L   GAS
Sbjct: 590 MPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGAS 635



 Score =  111 bits (278), Expect = 3e-24
 Identities = 85/270 (31%), Positives = 137/270 (50%), Gaps = 12/270 (4%)

Query: 542 DPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEAL 601
           D +  ++ G   +  AA  GN Q L+LL++       DV+     + ++ AA +GH + L
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRI--DVQDKGGSNAVYWAARHGHVDTL 428

Query: 602 KTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAA 661
           K L+E    LDV+D  G  AL +A   G  +  ++L + G++  I++++ + TPLH AA 
Sbjct: 429 KFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEE-TPLHCAAW 487

Query: 662 SGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRG 721
            G+      L ++G   +I +     G+TPL+ A   G+ D V  L E G+  +A D  G
Sbjct: 488 HGYYSVAKALCEAGCNVNIKN---REGETPLLTASARGYHDIVECLAEHGADLNACDKDG 544

Query: 722 RTALHRGAVTGCE-DCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALST 780
             ALH  AV  C+ + +  LL    FV  +D  G TP+H+A   G+  ++  L +A  + 
Sbjct: 545 HIALHL-AVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCN- 602

Query: 781 DPLDAGVDYSGYSPMHWASYTGHEDCLELL 810
             LD    Y G +P+H A+  G  D +  L
Sbjct: 603 --LDISNKY-GRTPLHLAANNGILDVVRYL 629



 Score =  107 bits (268), Expect = 5e-23
 Identities = 83/292 (28%), Positives = 135/292 (46%), Gaps = 19/292 (6%)

Query: 198 DLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIE 257
           D+   ++ G   L  AA  G I++++ L++ G+ ID  +  G+ A++ A   G       
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430

Query: 258 LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHG 317
           L      ++  +  G   LHVAA   +  +  +LL + G++ N Q KE ++PLH AA HG
Sbjct: 431 LSENKCPLDVKDKSGEMALHVAARYGHADVA-QLLCSFGSNPNIQDKEEETPLHCAAWHG 489

Query: 318 RFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLH 377
            ++ ++ L + G  ++  ++ G TPL  A+  G+  ++  L  +GAD           LH
Sbjct: 490 YYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALH 549

Query: 378 LAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVE 437
           LAV      C  +++ +              +LS G  ++  D  G T LH A   GN+ 
Sbjct: 550 LAV----RRCQMEVIKT--------------LLSQGCFVDYQDRHGNTPLHVACKDGNMP 591

Query: 438 CLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 489
            +  L  +  +L   +K+GRTPLH AA NG       L   GA V      G
Sbjct: 592 IVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDG 643



 Score =  104 bits (259), Expect = 5e-22
 Identities = 90/328 (27%), Positives = 148/328 (45%), Gaps = 41/328 (12%)

Query: 397 LYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFG 456
           L  ++ SLSN       +D+N P+  G   L  AA  GN++ L LL+  G+ +  +DK G
Sbjct: 360 LQHLLGSLSN-------YDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGG 412

Query: 457 RTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAE 516
              +++AA +G       L      ++  D  G   LH AA    Y  A+          
Sbjct: 413 SNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAA---RYGHAD---------- 459

Query: 517 EDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNC 576
                            + L   G++P+++D++  T +H AA +G     + L E    C
Sbjct: 460 ---------------VAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA--GC 502

Query: 577 LEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEV 636
             ++++    +PL  A+  G+ + ++ LAE   +L+  D  G  AL LA  R   E ++ 
Sbjct: 503 NVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKT 562

Query: 637 LTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAI 696
           L + G     ++R    TPLH A   G+   +  L ++    DI+   + YG+TPL LA 
Sbjct: 563 LLSQGCFVDYQDRHGN-TPLHVACKDGNMPIVVALCEANCNLDIS---NKYGRTPLHLAA 618

Query: 697 MNGHVDCVHLLLEKGSTADAADLRGRTA 724
            NG +D V  L   G++ +A    G+TA
Sbjct: 619 NNGILDVVRYLCLMGASVEALTTDGKTA 646



 Score =  103 bits (257), Expect = 9e-22
 Identities = 90/297 (30%), Positives = 131/297 (44%), Gaps = 11/297 (3%)

Query: 655 PLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTA 714
           PL  AA  G+   L LLI  G R D   V D  G   +  A  +GHVD +  L E     
Sbjct: 382 PLLIAAGCGNIQILQLLIKRGSRID---VQDKGGSNAVYWAARHGHVDTLKFLSENKCPL 438

Query: 715 DAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLL 774
           D  D  G  ALH  A  G  D    L    +    +D +  TP+H A+  G+ +V + L 
Sbjct: 439 DVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALC 498

Query: 775 QAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPFSYLEGNPFTPLHCAVIN 833
           +A  + +  +      G +P+  AS  G+ D +E L EH +  +  + +    LH AV  
Sbjct: 499 EAGCNVNIKNR----EGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRR 554

Query: 834 NQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRT 893
            Q    + LL       V+ +D  G TPLH A    N+  +  L +    ++ ++  GRT
Sbjct: 555 CQMEVIKTLLSQ--GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRT 612

Query: 894 ALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQD 950
            L  AA NG    V +L   G A +  L  +  TA  LA S+ HE  A ++    +D
Sbjct: 613 PLHLAANNGILDVVRYLCLMG-ASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKD 668



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 88/311 (28%), Positives = 134/311 (43%), Gaps = 44/311 (14%)

Query: 687 YGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAF 746
           +G  PL++A   G++  + LL+++GS  D  D  G  A++  A  G  D L  L ++   
Sbjct: 378 HGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKC- 436

Query: 747 VLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDC 806
                                              PLD   D SG   +H A+  GH D 
Sbjct: 437 -----------------------------------PLDVK-DKSGEMALHVAARYGHADV 460

Query: 807 LELLLEHSPFSYLEGNPF-TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAA 865
            +LL        ++     TPLHCA  +   S  + L  A G   VN ++ +G TPL  A
Sbjct: 461 AQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA-GCN-VNIKNREGETPLLTA 518

Query: 866 AFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENK 925
           +       +  L +H A++NA D  G  AL  A    Q   ++ LL +G   +   D + 
Sbjct: 519 SARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQG-CFVDYQDRHG 577

Query: 926 NTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGA 985
           NT LH+AC  G+    + +     +L + N      + PLH+AA NG+  VV+ L   GA
Sbjct: 578 NTPLHVACKDGNMPIVVALCEANCNLDISNKYG---RTPLHLAANNGILDVVRYLCLMGA 634

Query: 986 TVLAVDEEGHT 996
           +V A+  +G T
Sbjct: 635 SVEALTTDGKT 645



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 80/288 (27%), Positives = 133/288 (46%), Gaps = 16/288 (5%)

Query: 724  ALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPL 783
            A++   V G +  L +L ++D  V   +  G  P+ +A+ CG+  +L+ L++     D  
Sbjct: 351  AINDDNVPGLQHLLGSLSNYD--VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQ 408

Query: 784  DAGVDYSGYSPMHWASYTGHEDCLELLLEHS-PFSYLEGNPFTPLHCAVINNQDSTTEML 842
            D G    G + ++WA+  GH D L+ L E+  P    + +    LH A         ++L
Sbjct: 409  DKG----GSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLL 464

Query: 843  LGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENG 902
              + G+   N +D +  TPLH AA+    S  + L +    VN  +  G T L+TA+  G
Sbjct: 465  C-SFGSN-PNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARG 522

Query: 903  QTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLG-LINATNSAL 961
                VE L   G ADL   D++ + ALHLA      +C + ++      G  ++  +   
Sbjct: 523  YHDIVECLAEHG-ADLNACDKDGHIALHLAV----RRCQMEVIKTLLSQGCFVDYQDRHG 577

Query: 962  QMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVAD 1009
              PLH+A ++G   +V AL      +   ++ G TP L  A N  + D
Sbjct: 578  NTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTP-LHLAANNGILD 624



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 38/151 (25%), Positives = 65/151 (43%)

Query: 9   QPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVN 68
           + PL+ A      + V  L     ++N  D++    LH A     + +++ LL  G  V+
Sbjct: 512 ETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVD 571

Query: 69  AKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128
            +D    TPLH A    N  ++  L   + +++  +K  +TPLH+AA N        L  
Sbjct: 572 YQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCL 631

Query: 129 LLSSLNVADRSGRSALHHAVHSGHLETVNLL 159
           + +S+      G++A   A    H     LL
Sbjct: 632 MGASVEALTTDGKTAEDLARSEQHEHVAGLL 662



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 33/109 (30%), Positives = 53/109 (48%)

Query: 21  VEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHR 80
           +E +++LLSQ   ++  D+   TPLH A   G++PI+  L  +  N++  +    TPLH 
Sbjct: 557 MEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHL 616

Query: 81  AAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
           AA +    V+  L    A V A     +T   +A + +    A  LA L
Sbjct: 617 AANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARL 665


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,459,295
Number of Sequences: 37866
Number of extensions: 1810650
Number of successful extensions: 23818
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 366
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 4015
Number of HSP's gapped (non-prelim): 6618
length of query: 1076
length of database: 18,247,518
effective HSP length: 113
effective length of query: 963
effective length of database: 13,968,660
effective search space: 13451819580
effective search space used: 13451819580
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.