Search of human proteins with 157743267

Search of human proteins with 157743267

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157743267 ankyrin repeat domain 58 [Homo sapiens]
         (315 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157743267 ankyrin repeat domain 58 [Homo sapiens]                  637   0.0  
gi|54607077 ankyrin repeat domain 57 [Homo sapiens]                   135   6e-32
gi|95147559 ankyrin repeat domain 43 [Homo sapiens]                   125   6e-29
gi|71274172 ankyrin repeat domain 56 [Homo sapiens]                   101   8e-22
gi|17981699 cyclin-dependent kinase inhibitor 2C [Homo sapiens]        50   2e-06
gi|4502751 cyclin-dependent kinase inhibitor 2C [Homo sapiens]         50   2e-06
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                   50   3e-06
gi|38176283 ankyrin repeat and SOCS box-containing protein 7 iso...    49   4e-06
gi|30089994 ankyrin repeat and SOCS box-containing protein 7 iso...    49   4e-06
gi|239754056 PREDICTED: ankyrin repeat and death domain containi...    49   6e-06
gi|239748583 PREDICTED: ankyrin repeat and death domain containi...    49   6e-06
gi|239742602 PREDICTED: ankyrin repeat and death domain containi...    49   6e-06
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ...    49   6e-06
gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo ...    49   6e-06
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...    47   2e-05
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]             45   6e-05
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...    45   6e-05
gi|62420875 integrin-linked kinase [Homo sapiens]                      45   8e-05
gi|62420873 integrin-linked kinase [Homo sapiens]                      45   8e-05
gi|4758606 integrin-linked kinase [Homo sapiens]                       45   8e-05
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...    45   1e-04
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                    44   1e-04
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        43   3e-04
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         43   3e-04
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         43   3e-04
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         43   3e-04
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         43   3e-04
gi|124517699 ankyrin repeat domain 13B [Homo sapiens]                  43   4e-04
gi|70995241 ankyrin repeat domain 10 [Homo sapiens]                    42   5e-04
gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens]          42   7e-04

>gi|157743267 ankyrin repeat domain 58 [Homo sapiens]
          Length = 315

 Score =  637 bits (1644), Expect = 0.0
 Identities = 315/315 (100%), Positives = 315/315 (100%)

Query: 1   MAQLGGAANRAPTASLAPTSQSLRCAPQPRPSRADTGSLGRYWGKAAAAASREHPFPGTL 60
           MAQLGGAANRAPTASLAPTSQSLRCAPQPRPSRADTGSLGRYWGKAAAAASREHPFPGTL
Sbjct: 1   MAQLGGAANRAPTASLAPTSQSLRCAPQPRPSRADTGSLGRYWGKAAAAASREHPFPGTL 60

Query: 61  MHSAAGSGRRRGALRELLGLQRAAPAGWLSEERAEELGGPSGPGSSRLCLEPREHAWILA 120
           MHSAAGSGRRRGALRELLGLQRAAPAGWLSEERAEELGGPSGPGSSRLCLEPREHAWILA
Sbjct: 61  MHSAAGSGRRRGALRELLGLQRAAPAGWLSEERAEELGGPSGPGSSRLCLEPREHAWILA 120

Query: 121 AAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDV 180
           AAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDV
Sbjct: 121 AAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDV 180

Query: 181 SAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHYLRPDAPWRLRELS 240
           SAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHYLRPDAPWRLRELS
Sbjct: 181 SAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHYLRPDAPWRLRELS 240

Query: 241 GAEEWEMESGSGCTNLNNNSSGTTAWRAASAVGATAVETSRRVAASRTKAKDTAGSRVAQ 300
           GAEEWEMESGSGCTNLNNNSSGTTAWRAASAVGATAVETSRRVAASRTKAKDTAGSRVAQ
Sbjct: 241 GAEEWEMESGSGCTNLNNNSSGTTAWRAASAVGATAVETSRRVAASRTKAKDTAGSRVAQ 300

Query: 301 MHSLFRHLFPSFQDR 315
           MHSLFRHLFPSFQDR
Sbjct: 301 MHSLFRHLFPSFQDR 315


>gi|54607077 ankyrin repeat domain 57 [Homo sapiens]
          Length = 525

 Score =  135 bits (339), Expect = 6e-32
 Identities = 86/216 (39%), Positives = 124/216 (57%), Gaps = 21/216 (9%)

Query: 58  GTLMHSAAGSGRRRGALRELLGLQRAAPAGWLSEERAEELGGPSGPGSSRLCLEPREHAW 117
           G+   S++G GR RG          A+ A   +EE +      SG GS  + L+P EHAW
Sbjct: 224 GSSPGSSSGGGRGRGGGDS----DSASVASSSAEEES------SGGGS--VTLDPLEHAW 271

Query: 118 ILAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLR 177
           +L+A++G+++ L  LL  EP LL++ D ITG++ LHW AKHGR E L ++ +FA +  L 
Sbjct: 272 MLSASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLP 331

Query: 178 LDVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHYLRPDAPWRLR 237
           +++ A  SGG T LHLAA+ GH  V+K+LVGA  AD   RD+SG +A  YL       ++
Sbjct: 332 VNIDARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSGKKASQYLSRSIAEEIK 391

Query: 238 ELSGA-EEWEMESGSGCTNLNNNSSGTTAWRAASAV 272
            L GA +E + ES +G        SG   WR +  +
Sbjct: 392 NLVGALDEGDGESAAG--------SGGGRWRLSKVL 419


>gi|95147559 ankyrin repeat domain 43 [Homo sapiens]
          Length = 549

 Score =  125 bits (313), Expect = 6e-29
 Identities = 98/282 (34%), Positives = 130/282 (46%), Gaps = 16/282 (5%)

Query: 8   ANRAPTASLAPTSQS-----LRCAPQPRPSRADTGSLGRYWGKAAAAASREHPF---PGT 59
           A   P A+  P  Q      +RC P P   R      G     +   + R  P      +
Sbjct: 201 AEPGPGAAKGPPQQKPCMLPVRCVPAPATLRLRAEEPGLRRQLSEEPSPRSSPLLLRRLS 260

Query: 60  LMHSAAGSGRRRGALRELLGLQRAAPAGWLSEERAEELGGPSGPGSSRLCLEPREHAWIL 119
           +  S  G G   G    L  L RA P   L    AEEL  P+ P  S + LEP EH W++
Sbjct: 261 VEESGLGLGLGPGRSPHLRRLSRAGPR--LLSPDAEEL--PAAPPPSAVPLEPSEHEWLV 316

Query: 120 AAAEGRY-EVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
             A GR+   L  LL  +  L  + D ++G++ LHW AK G  E  + + + A R G  +
Sbjct: 317 RTAGGRWTHQLHGLLLRDRGLAAKRDFMSGFTALHWAAKSGDGEMALQLVEVARRSGAPV 376

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHYLRPDAPWRLRE 238
           DV+A   GG TPLHLAAL GH+    +LV  LGA    RDHSG RA  YLRP + + LR 
Sbjct: 377 DVNARSHGGYTPLHLAALHGHEDAAVLLVVRLGAQVHVRDHSGRRAYQYLRPGSSYALRR 436

Query: 239 LSGAEEWEMESGSGCTNLNNNSSGTTAWRAASAVGATAVETS 280
           L G        G+   +     SG+ A R    V AT + ++
Sbjct: 437 LLGDPGLR---GTTEPDATGGGSGSLAARRPVQVAATILSST 475


>gi|71274172 ankyrin repeat domain 56 [Homo sapiens]
          Length = 793

 Score =  101 bits (252), Expect = 8e-22
 Identities = 65/172 (37%), Positives = 86/172 (50%), Gaps = 18/172 (10%)

Query: 84  APAGWLSEERAEELGGPSGPGSSRLC-------------LEPREHAWILAAAEGRYEVLR 130
           A  GW        L  PSG GS+ L              L+ REH WI+  A G +  + 
Sbjct: 559 AERGW-----RHSLWVPSGEGSAALAPHRTSEHKSSLVPLDAREHEWIVKLASGSWIQVW 613

Query: 131 ELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTP 190
            L   +P+L L  D +TGY+ LHW+AKHG    L  +   A + G+ LDV+   S G TP
Sbjct: 614 TLFWEDPQLALHKDFLTGYTALHWIAKHGDLRALQDLVSGAKKAGIVLDVNVRSSCGYTP 673

Query: 191 LHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHYLRPDAPWRLRELSGA 242
           LHLAA+ GH  VIK+LV  L +    RD SG +   YL  +    + +L GA
Sbjct: 674 LHLAAIHGHQGVIKLLVQRLASRVNVRDSSGKKPWQYLTSNTSGEIWQLLGA 725


>gi|17981699 cyclin-dependent kinase inhibitor 2C [Homo sapiens]
          Length = 168

 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 37/108 (34%), Positives = 55/108 (50%), Gaps = 12/108 (11%)

Query: 124 GRYEVLRELL--EAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVS 181
           G  E+ R LL   A P+L  R    TG++V+H  A+ G  + L  + +F      + DV+
Sbjct: 48  GNPEIARRLLLRGANPDLKDR----TGFAVIHDAARAGFLDTLQTLLEF------QADVN 97

Query: 182 APGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHYLR 229
              + G  PLHLAA +GH  V++ LV    ++   R+H G  AC   R
Sbjct: 98  IEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLAR 145


>gi|4502751 cyclin-dependent kinase inhibitor 2C [Homo sapiens]
          Length = 168

 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 37/108 (34%), Positives = 55/108 (50%), Gaps = 12/108 (11%)

Query: 124 GRYEVLRELL--EAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVS 181
           G  E+ R LL   A P+L  R    TG++V+H  A+ G  + L  + +F      + DV+
Sbjct: 48  GNPEIARRLLLRGANPDLKDR----TGFAVIHDAARAGFLDTLQTLLEF------QADVN 97

Query: 182 APGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHYLR 229
              + G  PLHLAA +GH  V++ LV    ++   R+H G  AC   R
Sbjct: 98  IEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLAR 145


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 40/114 (35%), Positives = 53/114 (46%), Gaps = 16/114 (14%)

Query: 119 LAAAEGRYEVLRELLEA--EPELLLRGDPITGYSVLHWLAKHGRHE--ELILVHD-FALR 173
           LA+A G   VLR LL+A    + L  G   +GYS +HW +  G  +  EL+L H  F+  
Sbjct: 760 LASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYL 819

Query: 174 RGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGAD-ATRRDHSGHRACH 226
            G             TPLH A +   D   ++L+GALGA     RD  G    H
Sbjct: 820 EG----------NPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLH 863



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 5/77 (6%)

Query: 148 GYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           GY+ +H+ A +G  + L L+ + +      ++ + P    ++PLHLAA  GH   +K L 
Sbjct: 550 GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIP----VSPLHLAAYNGHCEALKTLA 605

Query: 208 GALGADATRRDHSGHRA 224
             L  +   RDH G  A
Sbjct: 606 ETL-VNLDVRDHKGRTA 621



 Score = 38.1 bits (87), Expect = 0.010
 Identities = 26/70 (37%), Positives = 37/70 (52%), Gaps = 7/70 (10%)

Query: 148 GYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           G S LH  A HGR     ++    ++ G  +D +     G TPLH+AA  GH+++I  L+
Sbjct: 306 GKSPLHMAAIHGRFTRSQIL----IQNGSEIDCA--DKFGNTPLHVAARYGHELLISTLM 359

Query: 208 GALGADATRR 217
              GAD  RR
Sbjct: 360 -TNGADTARR 368



 Score = 35.8 bits (81), Expect = 0.051
 Identities = 30/80 (37%), Positives = 39/80 (48%), Gaps = 7/80 (8%)

Query: 147 TGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVL 206
           +G S LH  A H  H E +   +  L +G  L+V         PLH AA  GH  V+K+L
Sbjct: 139 SGRSALHH-AVHSGHLETV---NLLLNKGASLNVCDKKER--QPLHWAAFLGHLEVLKLL 192

Query: 207 VGALGADATRRDHSGHRACH 226
           V A GAD   +D  G+   H
Sbjct: 193 V-ARGADLGCKDRKGYGLLH 211



 Score = 35.0 bits (79), Expect = 0.087
 Identities = 28/93 (30%), Positives = 45/93 (48%), Gaps = 5/93 (5%)

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHYLRPDAPWRLR- 237
           D++ P + G T LH AA  G+   + +L+ + GAD  RRD  G    HY   +  ++   
Sbjct: 415 DINTPDNLGRTCLHAAASGGNVECLNLLLSS-GADLRRRDKFGRTPLHYAAANGSYQCAV 473

Query: 238 --ELSGAEEWEMESGSGCTNLNNNSSGTTAWRA 268
               +GA   E +   GC+ L+  ++  T  RA
Sbjct: 474 TLVTAGAGVNEADC-KGCSPLHYAAASDTYRRA 505



 Score = 33.1 bits (74), Expect = 0.33
 Identities = 33/109 (30%), Positives = 49/109 (44%), Gaps = 12/109 (11%)

Query: 120 AAAEGRYEVLRELLEAEPELLLRGDPIT-GYSVLHWLAKHGRHEELI-LVHDFALRRGLR 177
           AAA G+ EV++ LL    E+    +P   G + LH     G+    I LV+  A      
Sbjct: 213 AAASGQIEVVKYLLRMGAEI---DEPNAFGNTALHIACYLGQDAVAIELVNAGA------ 263

Query: 178 LDVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACH 226
            +V+ P   G TPLH+AA+  +  +   L+   GAD   +   G    H
Sbjct: 264 -NVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLH 311



 Score = 32.0 bits (71), Expect = 0.73
 Identities = 52/187 (27%), Positives = 76/187 (40%), Gaps = 37/187 (19%)

Query: 47  AAAASREHPFPGTLMHSAAGSGRRRGALRELLGLQRAAPAGWLSEERAEELGGPSGPGSS 106
           A+A  +E     T +H+AA SG    +L  L+           S ERA+        G +
Sbjct: 642 ASALIKERKRKWTPLHAAAASGHT-DSLHLLID----------SGERADITDVMDAYGQT 690

Query: 107 RLCLEPREHAWILAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEEL-- 164
            L         +LA   G  + +  LLE           + G + LH  A  G  + L  
Sbjct: 691 PL---------MLAIMNGHVDCVHLLLEKGSTA--DAADLRGRTALHRGAVTGCEDCLAA 739

Query: 165 ILVHD-FALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLV-GALGADATRR--DHS 220
           +L HD F L R  +         G TP+HLA+  GH  V++ L+  AL  D      D+S
Sbjct: 740 LLDHDAFVLCRDFK---------GRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYS 790

Query: 221 GHRACHY 227
           G+   H+
Sbjct: 791 GYSPMHW 797


>gi|38176283 ankyrin repeat and SOCS box-containing protein 7
           isoform 2 [Homo sapiens]
          Length = 318

 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 43/142 (30%), Positives = 67/142 (47%), Gaps = 14/142 (9%)

Query: 69  RRRGALRELLGLQRAAPAGWLSEERAEELGGPSGPGSSRLCLEPREHAWIL---AAAEGR 125
           RR   L+E L +Q A  AG +   R     G S  G          + W L   +AA G+
Sbjct: 7   RRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDA-------NGWTLLHFSAARGK 59

Query: 126 YEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGS 185
              +R  LE   +  ++ D I G++ LH+ A HGR     L+ +   R  +   ++A  +
Sbjct: 60  ERCVRVFLEHGADPTVK-DLIGGFTALHYAAMHGRARIARLMLESEYRSDI---INAKSN 115

Query: 186 GGLTPLHLAALQGHDMVIKVLV 207
            G TPLH+AA  G D  +++L+
Sbjct: 116 DGWTPLHVAAHYGRDSFVRLLL 137



 Score = 35.4 bits (80), Expect = 0.066
 Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 7/89 (7%)

Query: 120 AAAEGRYEVLRELLEAEPEL-LLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           AA  GR  + R +LE+E    ++      G++ LH  A +GR   + L+ +F      + 
Sbjct: 88  AAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEF------KA 141

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           +V      G TPL LA ++     +K+L+
Sbjct: 142 EVDPLSDKGTTPLQLAIIRERSSCVKILL 170


>gi|30089994 ankyrin repeat and SOCS box-containing protein 7
           isoform 1 [Homo sapiens]
          Length = 274

 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 43/142 (30%), Positives = 67/142 (47%), Gaps = 14/142 (9%)

Query: 69  RRRGALRELLGLQRAAPAGWLSEERAEELGGPSGPGSSRLCLEPREHAWIL---AAAEGR 125
           RR   L+E L +Q A  AG +   R     G S  G          + W L   +AA G+
Sbjct: 7   RRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDA-------NGWTLLHFSAARGK 59

Query: 126 YEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGS 185
              +R  LE   +  ++ D I G++ LH+ A HGR     L+ +   R  +   ++A  +
Sbjct: 60  ERCVRVFLEHGADPTVK-DLIGGFTALHYAAMHGRARIARLMLESEYRSDI---INAKSN 115

Query: 186 GGLTPLHLAALQGHDMVIKVLV 207
            G TPLH+AA  G D  +++L+
Sbjct: 116 DGWTPLHVAAHYGRDSFVRLLL 137



 Score = 35.4 bits (80), Expect = 0.066
 Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 7/89 (7%)

Query: 120 AAAEGRYEVLRELLEAEPEL-LLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           AA  GR  + R +LE+E    ++      G++ LH  A +GR   + L+ +F      + 
Sbjct: 88  AAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEF------KA 141

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           +V      G TPL LA ++     +K+L+
Sbjct: 142 EVDPLSDKGTTPLQLAIIRERSSCVKILL 170


>gi|239754056 PREDICTED: ankyrin repeat and death domain containing
           1B [Homo sapiens]
          Length = 524

 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 72/276 (26%), Positives = 109/276 (39%), Gaps = 49/276 (17%)

Query: 40  GRYWGKAAAAASREHPFPGTLMHSAAGSGRRRGALRELLGLQRAAPAGWLSEERA---EE 96
           GR  G+ A A        G L+ +AA +   +G   +L G   AA   W S  R    E 
Sbjct: 5   GRARGQGATAG-------GLLLRAAAAA---KGLREDLWG---AAALPWRSLSRIPKREG 51

Query: 97  LGGPSGPGSSRLCLEPREHAWILAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLA 156
           LG      +    L P E ++  AA     +++ +L E +  + +  +     + LH+  
Sbjct: 52  LGEEDTAVAGHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNN--MNRTALHFAV 109

Query: 157 KHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATR 216
             GR+   +   DF L+   R+DV+     GLT +HLAA  G   V+ +LV A GAD   
Sbjct: 110 --GRNH--LSAVDFLLKHKARVDVA--DKHGLTVIHLAAWSGSLEVMLMLVKA-GADQRA 162

Query: 217 RDHSGHRACHYL----------------------RPDAPWRLRELSGAEEWEMESGSGCT 254
           ++  G  A H+                       +PD   R   L  AE   +E     T
Sbjct: 163 KNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLT 222

Query: 255 --NLNNNSSGTTAWRAASAVGATAVETSRRVAASRT 288
             NL+ +      W        T ++TSR   A+ T
Sbjct: 223 FLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALT 258


>gi|239748583 PREDICTED: ankyrin repeat and death domain containing
           1B [Homo sapiens]
          Length = 524

 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 72/276 (26%), Positives = 109/276 (39%), Gaps = 49/276 (17%)

Query: 40  GRYWGKAAAAASREHPFPGTLMHSAAGSGRRRGALRELLGLQRAAPAGWLSEERA---EE 96
           GR  G+ A A        G L+ +AA +   +G   +L G   AA   W S  R    E 
Sbjct: 5   GRARGQGATAG-------GLLLRAAAAA---KGLREDLWG---AAALPWRSLSRIPKREG 51

Query: 97  LGGPSGPGSSRLCLEPREHAWILAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLA 156
           LG      +    L P E ++  AA     +++ +L E +  + +  +     + LH+  
Sbjct: 52  LGEEDTAVAGHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNN--MNRTALHFAV 109

Query: 157 KHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATR 216
             GR+   +   DF L+   R+DV+     GLT +HLAA  G   V+ +LV A GAD   
Sbjct: 110 --GRNH--LSAVDFLLKHKARVDVA--DKHGLTVIHLAAWSGSLEVMLMLVKA-GADQRA 162

Query: 217 RDHSGHRACHYL----------------------RPDAPWRLRELSGAEEWEMESGSGCT 254
           ++  G  A H+                       +PD   R   L  AE   +E     T
Sbjct: 163 KNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLT 222

Query: 255 --NLNNNSSGTTAWRAASAVGATAVETSRRVAASRT 288
             NL+ +      W        T ++TSR   A+ T
Sbjct: 223 FLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALT 258


>gi|239742602 PREDICTED: ankyrin repeat and death domain containing
           1B [Homo sapiens]
          Length = 607

 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 72/276 (26%), Positives = 109/276 (39%), Gaps = 49/276 (17%)

Query: 40  GRYWGKAAAAASREHPFPGTLMHSAAGSGRRRGALRELLGLQRAAPAGWLSEERA---EE 96
           GR  G+ A A        G L+ +AA +   +G   +L G   AA   W S  R    E 
Sbjct: 5   GRARGQGATAG-------GLLLRAAAAA---KGLREDLWG---AAALPWRSLSRIPKREG 51

Query: 97  LGGPSGPGSSRLCLEPREHAWILAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLA 156
           LG      +    L P E ++  AA     +++ +L E +  + +  +     + LH+  
Sbjct: 52  LGEEDTAVAGHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNN--MNRTALHFAV 109

Query: 157 KHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATR 216
             GR+   +   DF L+   R+DV+     GLT +HLAA  G   V+ +LV A GAD   
Sbjct: 110 --GRNH--LSAVDFLLKHKARVDVA--DKHGLTVIHLAAWSGSLEVMLMLVKA-GADQRA 162

Query: 217 RDHSGHRACHYL----------------------RPDAPWRLRELSGAEEWEMESGSGCT 254
           ++  G  A H+                       +PD   R   L  AE   +E     T
Sbjct: 163 KNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLT 222

Query: 255 --NLNNNSSGTTAWRAASAVGATAVETSRRVAASRT 288
             NL+ +      W        T ++TSR   A+ T
Sbjct: 223 FLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALT 258


>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
           sapiens]
          Length = 226

 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 35/107 (32%), Positives = 53/107 (49%), Gaps = 8/107 (7%)

Query: 121 AAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDV 180
           A  G+ E L+E + A+  L  R D     + LHW    G H E++   +F L+ G+   V
Sbjct: 14  AYSGKLEELKESILADKSLATRTDQ-DSRTALHWACSAG-HTEIV---EFLLQLGV--PV 66

Query: 181 SAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHY 227
           +     G +PLH+AA  G D ++K L+G  GA     + +G    HY
Sbjct: 67  NDKDDAGWSPLHIAASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHY 112



 Score = 37.7 bits (86), Expect = 0.013
 Identities = 34/108 (31%), Positives = 52/108 (48%), Gaps = 11/108 (10%)

Query: 120 AAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLD 179
           A + G  E++  LL+    +  + D   G+S LH  A  GR E    +    L +G +  
Sbjct: 47  ACSAGHTEIVEFLLQLGVPVNDKDD--AGWSPLHIAASAGRDE----IVKALLGKGAQ-- 98

Query: 180 VSAPGSGGLTPLHLAALQG-HDMVIKVLVGALGADATRRDHSGHRACH 226
           V+A    G TPLH AA +  H++ + +L G  GA+   +DH    A H
Sbjct: 99  VNAVNQNGCTPLHYAASKNRHEIAVMLLEG--GANPDAKDHYEATAMH 144


>gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo
           sapiens]
          Length = 151

 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 35/107 (32%), Positives = 53/107 (49%), Gaps = 8/107 (7%)

Query: 121 AAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDV 180
           A  G+ E L+E + A+  L  R D     + LHW    G H E++   +F L+ G+   V
Sbjct: 14  AYSGKLEELKESILADKSLATRTDQ-DSRTALHWACSAG-HTEIV---EFLLQLGV--PV 66

Query: 181 SAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHY 227
           +     G +PLH+AA  G D ++K L+G  GA     + +G    HY
Sbjct: 67  NDKDDAGWSPLHIAASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHY 112



 Score = 37.7 bits (86), Expect = 0.013
 Identities = 34/108 (31%), Positives = 52/108 (48%), Gaps = 11/108 (10%)

Query: 120 AAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLD 179
           A + G  E++  LL+    +  + D   G+S LH  A  GR E    +    L +G +  
Sbjct: 47  ACSAGHTEIVEFLLQLGVPVNDKDD--AGWSPLHIAASAGRDE----IVKALLGKGAQ-- 98

Query: 180 VSAPGSGGLTPLHLAALQG-HDMVIKVLVGALGADATRRDHSGHRACH 226
           V+A    G TPLH AA +  H++ + +L G  GA+   +DH    A H
Sbjct: 99  VNAVNQNGCTPLHYAASKNRHEIAVMLLEG--GANPDAKDHYEATAMH 144


>gi|116875852 HECT domain and ankyrin repeat containing, E3
           ubiquitin protein ligase 1 [Homo sapiens]
          Length = 909

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 9/103 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           LAA  G+ + + +LLE   ++ +  +   G + +HWLA +GR E   L+HD         
Sbjct: 104 LAARNGQKKCMSKLLEYSADVNICNNE--GLTAIHWLAVNGRTE---LLHDLVQHVS--- 155

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSG 221
           DV    + G T LH+A   GH   ++ L+ + GAD  R + SG
Sbjct: 156 DVDVEDAMGQTALHVACQNGHKTTVQCLLDS-GADINRPNVSG 197



 Score = 29.6 bits (65), Expect = 3.6
 Identities = 26/79 (32%), Positives = 37/79 (46%), Gaps = 7/79 (8%)

Query: 150 SVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLVGA 209
           S+LH  A  G  E L+L+    L++G   +       G TPLHLAA  G    +  L+  
Sbjct: 67  SLLHIAANCGSVECLVLL----LKKGANPNYQ--DISGCTPLHLAARNGQKKCMSKLL-E 119

Query: 210 LGADATRRDHSGHRACHYL 228
             AD    ++ G  A H+L
Sbjct: 120 YSADVNICNNEGLTAIHWL 138


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 62/214 (28%), Positives = 84/214 (39%), Gaps = 44/214 (20%)

Query: 99  GPSGPGSSRL----CLEPREHAWI----LAAAEGRYEVLRELLEAEPELLLRGDPI---- 146
           GP+G  +  L     +E R+HA      LA   G   ++R LL+       RG P+    
Sbjct: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQ-------RGAPVGAVD 104

Query: 147 -TGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKV 205
             G + LH  A HG       V +  L+RG     +A    GLTPLH AA  GH ++   
Sbjct: 105 RAGRTALHEAAWHGHSR----VAELLLQRGA--SAAARSGTGLTPLHWAAALGHTLLAAR 158

Query: 206 LVGALG---ADATRRDHSGHRACHYLRPDAPWRLRELSGAEEWEMESGSGCTNLNNNSSG 262
           L+ A G   A A   D  G  A H+        + EL  A       G+G          
Sbjct: 159 LLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAA------GGAGLDG------- 205

Query: 263 TTAWRAASAVGATAVETSRRVAASRTKAKDTAGS 296
             A   A+A G  A         +R  A+D AG+
Sbjct: 206 --ALLVAAAAGRGAALRFLLARGARVDARDGAGA 237



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 70/235 (29%), Positives = 84/235 (35%), Gaps = 52/235 (22%)

Query: 33  RADTGSLGRYWGKAAAAASREHPFPGTLMHSAAGSGRRRGALRELLGLQRAAPAG----- 87
           R   G + +   + A+   R+H    T +H A   G     L  LL LQR AP G     
Sbjct: 51  RGPAGLVTQLLRQGASVEERDHA-GRTPLHLAVLRGH--APLVRLL-LQRGAPVGAVDRA 106

Query: 88  ---------WLSEERAEEL---GGPSGPGSSRLCLEPREHAWILAAAEGRYEVLRELLEA 135
                    W    R  EL    G S    S   L P    W  AAA G   +   LLEA
Sbjct: 107 GRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLH--W--AAALGHTLLAARLLEA 162

Query: 136 EPE--LLLRGDPITGYSVLHWLAKHGRHEELILVHD----------------------FA 171
                     +   G++  HW A  GR   L L+                        F 
Sbjct: 163 PGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFL 222

Query: 172 LRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACH 226
           L RG R+D  A    G T L LAA  G    I+VL+G  GAD   RD  G  A H
Sbjct: 223 LARGARVD--ARDGAGATALGLAAALGRSQDIEVLLGH-GADPGIRDRHGRSALH 274



 Score = 36.6 bits (83), Expect = 0.030
 Identities = 50/196 (25%), Positives = 75/196 (38%), Gaps = 22/196 (11%)

Query: 32  SRADTGSLGRYWGKAAAAASREHPFPGTLMHSAAGSGRRRGALRELLGLQRAAPAGWLSE 91
           +R+ TG    +W     AA+  H      +  A G G       +  G   A  A     
Sbjct: 135 ARSGTGLTPLHW-----AAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGR 189

Query: 92  ERAEELGGPSGPGSSRLCLEPREHAWILAAAEGRYEVLRELLEAEPELLLRGDPITGYSV 151
               EL    G G         + A ++AAA GR   LR LL     +  R     G + 
Sbjct: 190 LAVLELLAAGGAGL--------DGALLVAAAAGRGAALRFLLARGARVDARDG--AGATA 239

Query: 152 LHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLVGALG 211
           L   A  GR +++ ++       G+R         G + LH AA +GH + +++LV   G
Sbjct: 240 LGLAAALGRSQDIEVLLGHGADPGIR------DRHGRSALHRAAARGHLLAVQLLV-TQG 292

Query: 212 ADATRRDHSGHRACHY 227
           A+   RD  G    H+
Sbjct: 293 AEVDARDTLGLTPLHH 308



 Score = 36.2 bits (82), Expect = 0.039
 Identities = 56/178 (31%), Positives = 73/178 (41%), Gaps = 29/178 (16%)

Query: 26  APQPRPSRADTGSLGRYWGKA--AAAASREHPFPGTLMHSAAGSGRRRGALRELLGLQRA 83
           AP P P+ A+     R W  A  AAA  R       L   AAG     GAL       R 
Sbjct: 162 APGPGPAAAEAED-ARGWTAAHWAAAGGRL----AVLELLAAGGAGLDGALLVAAAAGRG 216

Query: 84  APAGWLSEERAEELGGPSGPGSSRLCLEPREHAWILAAAEGRYEVLRELLE--AEPELLL 141
           A   +L   R   +    G G++ L L         AAA GR + +  LL   A+P +  
Sbjct: 217 AALRFLLA-RGARVDARDGAGATALGL---------AAALGRSQDIEVLLGHGADPGIRD 266

Query: 142 RGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGH 199
           R     G S LH  A  G     +L     + +G  +D  A  + GLTPLH A+ +GH
Sbjct: 267 RH----GRSALHRAAARGH----LLAVQLLVTQGAEVD--ARDTLGLTPLHHASREGH 314



 Score = 36.2 bits (82), Expect = 0.039
 Identities = 41/125 (32%), Positives = 56/125 (44%), Gaps = 10/125 (8%)

Query: 120 AAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLD 179
           AAA G    ++ L+    E+  R     G + LH  ++ G  E    V    L RG ++D
Sbjct: 276 AAARGHLLAVQLLVTQGAEVDARDT--LGLTPLHHASREGHVE----VAGCLLDRGAQVD 329

Query: 180 VSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHYLRPDAPWRLREL 239
             A G    TPLHLAA +GH   + +L+ + GA  T R      A      D P  L EL
Sbjct: 330 --ATGWLRKTPLHLAAERGHGPTVGLLL-SRGASPTLRTQWAEVA-QMPEGDLPQALPEL 385

Query: 240 SGAEE 244
            G E+
Sbjct: 386 GGGEK 390


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 56/201 (27%), Positives = 86/201 (42%), Gaps = 19/201 (9%)

Query: 32  SRADTGSLGRYWGKAAAAASREHPFPGTLMHSAAGSGRRR-GALREL---LGLQRAAPAG 87
           +R   G +  +W   AA A  E      L H AA       GAL E     G+     + 
Sbjct: 43  ARNHVGRVALHW---AAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSA 99

Query: 88  WLSEERAEELGGPSGPGSSRLCLEPREHAWIL--AAAEGRYEVLRELLEAEPELLLRGDP 145
           W    R  ++   SG   +++  E ++   +L  AA +G   VL  ++E   ++ L    
Sbjct: 100 WFGHLRILQILVNSG---AKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVD 156

Query: 146 ITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKV 205
             G +  H  A+HG+ + L    DF +  G   D +     G T LHLAA +GH  V++ 
Sbjct: 157 KLGRTAFHRAAEHGQLDAL----DFLVGSGC--DHNVKDKEGNTALHLAAGRGHMAVLQR 210

Query: 206 LVGALGADATRRDHSGHRACH 226
           LV  +G D   ++  G  A H
Sbjct: 211 LVD-IGLDLEEQNAEGLTALH 230



 Score = 34.7 bits (78), Expect = 0.11
 Identities = 37/108 (34%), Positives = 48/108 (44%), Gaps = 9/108 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           LAA  G   VL+ L++    L L      G + LH  A  G H + +      LR G   
Sbjct: 198 LAAGRGHMAVLQRLVDIG--LDLEEQNAEGLTALH-SAAGGSHPDCV---QLLLRAGST- 250

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACH 226
            V+A     L+ LH AAL G + V +VL+ A G  A   DH G    H
Sbjct: 251 -VNALTQKNLSCLHYAALSGSEDVSRVLIHA-GGCANVVDHQGASPLH 296



 Score = 31.6 bits (70), Expect = 0.96
 Identities = 29/92 (31%), Positives = 38/92 (41%), Gaps = 9/92 (9%)

Query: 187 GLTPLHLAALQGHDMVIKVLVGALGADATRR-DHSGHRACHYLRPDAPWRLRELSGAEEW 245
           GLT LH AA +GH  V+  ++  L   A    D  G  A H        R  E    +  
Sbjct: 124 GLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFH--------RAAEHGQLDAL 175

Query: 246 EMESGSGCTNLNNNSSGTTAWRAASAVGATAV 277
           +   GSGC +   +  G TA   A+  G  AV
Sbjct: 176 DFLVGSGCDHNVKDKEGNTALHLAAGRGHMAV 207


>gi|62420875 integrin-linked kinase [Homo sapiens]
          Length = 452

 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 38/106 (35%), Positives = 51/106 (48%), Gaps = 10/106 (9%)

Query: 123 EGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSA 182
           EG    +R  L+     L +GD   G+S LHW  + GR      V +  + RG R++V  
Sbjct: 10  EGNAVAVRLWLDNTENDLNQGDD-HGFSPLHWACREGRSA----VVEMLIMRGARINVMN 64

Query: 183 PGSGGLTPLHLAALQGH-DMVIKVLVGALGADATRRDHSGHRACHY 227
            G    TPLHLAA  GH D+V K+L     AD    +  G+   HY
Sbjct: 65  RGDD--TPLHLAASHGHRDIVQKLL--QYKADINAVNEHGNVPLHY 106



 Score = 32.7 bits (73), Expect = 0.43
 Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 120 AAAEGRYEVLRELLE--AEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLR 177
           A  EGR  V+  L+   A   ++ RGD     + LH  A HG  + +  +  +      +
Sbjct: 41  ACREGRSAVVEMLIMRGARINVMNRGDD----TPLHLAASHGHRDIVQKLLQY------K 90

Query: 178 LDVSAPGSGGLTPLHLAALQGHDMVIKVLV--GAL 210
            D++A    G  PLH A   G D V + LV  GAL
Sbjct: 91  ADINAVNEHGNVPLHYACFWGQDQVAEDLVANGAL 125


>gi|62420873 integrin-linked kinase [Homo sapiens]
          Length = 452

 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 38/106 (35%), Positives = 51/106 (48%), Gaps = 10/106 (9%)

Query: 123 EGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSA 182
           EG    +R  L+     L +GD   G+S LHW  + GR      V +  + RG R++V  
Sbjct: 10  EGNAVAVRLWLDNTENDLNQGDD-HGFSPLHWACREGRSA----VVEMLIMRGARINVMN 64

Query: 183 PGSGGLTPLHLAALQGH-DMVIKVLVGALGADATRRDHSGHRACHY 227
            G    TPLHLAA  GH D+V K+L     AD    +  G+   HY
Sbjct: 65  RGDD--TPLHLAASHGHRDIVQKLL--QYKADINAVNEHGNVPLHY 106



 Score = 32.7 bits (73), Expect = 0.43
 Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 120 AAAEGRYEVLRELLE--AEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLR 177
           A  EGR  V+  L+   A   ++ RGD     + LH  A HG  + +  +  +      +
Sbjct: 41  ACREGRSAVVEMLIMRGARINVMNRGDD----TPLHLAASHGHRDIVQKLLQY------K 90

Query: 178 LDVSAPGSGGLTPLHLAALQGHDMVIKVLV--GAL 210
            D++A    G  PLH A   G D V + LV  GAL
Sbjct: 91  ADINAVNEHGNVPLHYACFWGQDQVAEDLVANGAL 125


>gi|4758606 integrin-linked kinase [Homo sapiens]
          Length = 452

 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 38/106 (35%), Positives = 51/106 (48%), Gaps = 10/106 (9%)

Query: 123 EGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSA 182
           EG    +R  L+     L +GD   G+S LHW  + GR      V +  + RG R++V  
Sbjct: 10  EGNAVAVRLWLDNTENDLNQGDD-HGFSPLHWACREGRSA----VVEMLIMRGARINVMN 64

Query: 183 PGSGGLTPLHLAALQGH-DMVIKVLVGALGADATRRDHSGHRACHY 227
            G    TPLHLAA  GH D+V K+L     AD    +  G+   HY
Sbjct: 65  RGDD--TPLHLAASHGHRDIVQKLL--QYKADINAVNEHGNVPLHY 106



 Score = 32.7 bits (73), Expect = 0.43
 Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 120 AAAEGRYEVLRELLE--AEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLR 177
           A  EGR  V+  L+   A   ++ RGD     + LH  A HG  + +  +  +      +
Sbjct: 41  ACREGRSAVVEMLIMRGARINVMNRGDD----TPLHLAASHGHRDIVQKLLQY------K 90

Query: 178 LDVSAPGSGGLTPLHLAALQGHDMVIKVLV--GAL 210
            D++A    G  PLH A   G D V + LV  GAL
Sbjct: 91  ADINAVNEHGNVPLHYACFWGQDQVAEDLVANGAL 125


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 37/102 (36%), Positives = 53/102 (51%), Gaps = 18/102 (17%)

Query: 119 LAAAEGRYEVLRELLE--AEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGL 176
           LA   G+   ++ LL+  A P+ L +    +GY  LH  A  G++    L+    LR G 
Sbjct: 533 LAVERGKVRAIQHLLKSGAVPDALDQ----SGYGPLHTAAARGKY----LICKMLLRYGA 584

Query: 177 RLDVSAPGSGGLTPLHLAALQGHDMVIKVL------VGALGA 212
            L++  P   G TPLHLAA +GH  +I +L      +GALGA
Sbjct: 585 SLEL--PTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGA 624



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 35/107 (32%), Positives = 48/107 (44%), Gaps = 9/107 (8%)

Query: 120 AAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLD 179
           AAA G+Y + + LL     L L      G++ LH  A  G  E + L+ +     G    
Sbjct: 567 AAARGKYLICKMLLRYGASLELPTHQ--GWTPLHLAAYKGHLEIIHLLAESHANMG---- 620

Query: 180 VSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACH 226
             A G+   TPLHLAA  G + V+  L+   GAD    + SG    H
Sbjct: 621 --ALGAVNWTPLHLAARHGEEAVVSALL-QCGADPNAAEQSGWTPLH 664



 Score = 34.7 bits (78), Expect = 0.11
 Identities = 37/131 (28%), Positives = 55/131 (41%), Gaps = 38/131 (29%)

Query: 112 PREHAWI---LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELIL-- 166
           P    W    LAA +G  E++  L E+   +   G     ++ LH  A+HG  EE ++  
Sbjct: 589 PTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALG--AVNWTPLHLAARHG--EEAVVSA 644

Query: 167 ------------------VHDFALRRGLRL----------DVSAPGSGGLTPLHLAALQG 198
                             +H  A++R   L          +V A    G TP HLAAL+G
Sbjct: 645 LLQCGADPNAAEQSGWTPLH-LAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKG 703

Query: 199 HDMVIKVLVGA 209
           +  ++KVLV A
Sbjct: 704 NTAILKVLVEA 714



 Score = 29.3 bits (64), Expect = 4.8
 Identities = 33/109 (30%), Positives = 47/109 (43%), Gaps = 8/109 (7%)

Query: 118 ILAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLR 177
           +L AA+ +   L  LL A      R D   G++ LH+ A++G      L+ D        
Sbjct: 399 LLIAAQDQQPDLCALLLAHGADANRVDE-DGWAPLHFAAQNGDDGTARLLLDHGAC---- 453

Query: 178 LDVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACH 226
             V A    G TPLHLAA    + V ++LV +  AD    +  G    H
Sbjct: 454 --VDAQEREGWTPLHLAAQNNFENVARLLV-SRQADPNLHEAEGKTPLH 499


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 39/114 (34%), Positives = 53/114 (46%), Gaps = 18/114 (15%)

Query: 107 RLCLEPREHAWILAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEEL-I 165
           RLCL+       L A+E   +VL E   +  ++L   D     S LH  A HG H+ L +
Sbjct: 518 RLCLQ-------LIASETPLDVLMET--SGTDMLSDSDNRATISPLHLAAYHGHHQALEV 568

Query: 166 LVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDH 219
           LV          LD+    S G TPL LAA +GH   + VL+   GA    +D+
Sbjct: 569 LVQSL-------LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQ-GASILVKDY 614



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 9/108 (8%)

Query: 120 AAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLD 179
           AA  G  EV++ L+    E+  +      Y+ LH  A  G    +I V  + L  G+  D
Sbjct: 180 AAYMGHIEVVKLLVSHGAEVTCKDKK--SYTPLHAAASSG----MISVVKYLLDLGV--D 231

Query: 180 VSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHY 227
           ++ P + G TPLH+A   G D+V+  L+   GA   +++  G    H+
Sbjct: 232 MNEPNAYGNTPLHVACYNGQDVVVNELIDC-GAIVNQKNEKGFTPLHF 278



 Score = 38.5 bits (88), Expect = 0.008
 Identities = 26/79 (32%), Positives = 38/79 (48%), Gaps = 7/79 (8%)

Query: 148 GYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           G + LH  A HGR      +    ++ G  +D       G TPLH+AA  GH+++I  L+
Sbjct: 306 GKTPLHMTALHGRFSRSQTI----IQSGAVIDCE--DKNGNTPLHIAARYGHELLINTLI 359

Query: 208 GALGADATRRDHSGHRACH 226
            + GAD  +R   G    H
Sbjct: 360 TS-GADTAKRGIHGMFPLH 377



 Score = 37.0 bits (84), Expect = 0.023
 Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 13/114 (11%)

Query: 115 HAWILAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLA--KHGRHEELILVHDFAL 172
           H  ++   EG  E+L + L A    ++      G + LH  A   H    +L+L H+   
Sbjct: 793 HCAVINDNEGAAEMLIDTLGAS---IVNATDSKGRTPLHAAAFTDHVECLQLLLSHN--- 846

Query: 173 RRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACH 226
                  V++  S G TPL +AA  G    +++LV +  A+ T +D+S + A H
Sbjct: 847 -----AQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALH 895



 Score = 35.4 bits (80), Expect = 0.066
 Identities = 30/106 (28%), Positives = 51/106 (48%), Gaps = 7/106 (6%)

Query: 118 ILAAAEGRYEVLRELLE-AEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGL 176
           ++AA  G+   +  L+  A  EL L+ +  +  + LH     G     +L+ +    R L
Sbjct: 861 MMAAENGQTNTVEMLVSSASAELTLQDN--SKNTALHLACSKGHETSALLILEKITDRNL 918

Query: 177 RLDVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGH 222
              ++A  +   TPLH+AA  G  MV++ L+G  GA     D +G+
Sbjct: 919 ---INATNAALQTPLHVAARNGLTMVVQELLGK-GASVLAVDENGY 960



 Score = 34.7 bits (78), Expect = 0.11
 Identities = 31/114 (27%), Positives = 48/114 (42%), Gaps = 16/114 (14%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPIT----GYSVLHWLAKHGRHEELILVHDFALRR 174
           L+AA G   VL  LL++   +    +P T    GY+ LHW   +G        H+  +  
Sbjct: 725 LSAACGHIGVLGALLQSAASM--DANPATADNHGYTALHWACYNG--------HETCVEL 774

Query: 175 GLRLDVSAPGSGG-LTPLHLAALQGHDMVIKVLVGALGAD-ATRRDHSGHRACH 226
            L  +V     G   +PLH A +  ++   ++L+  LGA      D  G    H
Sbjct: 775 LLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLH 828



 Score = 32.7 bits (73), Expect = 0.43
 Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 5/89 (5%)

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHYLRPDAPWRLRE 238
           D+  P   G T LH AA  G+   + +L+   GAD  ++D  G    HY   +  ++   
Sbjct: 397 DIDTPDDFGRTCLHAAAAGGNLECLNLLLNT-GADFNKKDKFGRSPLHYAAANCNYQCLF 455

Query: 239 L---SGAEEWEMESGSGCTNLNNNSSGTT 264
               SGA   +++   GCT L+  ++  T
Sbjct: 456 ALVGSGASVNDLDE-RGCTPLHYAATSDT 483



 Score = 32.3 bits (72), Expect = 0.56
 Identities = 27/83 (32%), Positives = 42/83 (50%), Gaps = 9/83 (10%)

Query: 148 GYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           G + LH  A  G HEE +   D  L+ G +  +    S G TP+HL+A  GH  V+  L+
Sbjct: 686 GRTALHRGAVTG-HEECV---DALLQHGAKCLLR--DSRGRTPIHLSAACGHIGVLGALL 739

Query: 208 ---GALGADATRRDHSGHRACHY 227
               ++ A+    D+ G+ A H+
Sbjct: 740 QSAASMDANPATADNHGYTALHW 762



 Score = 31.6 bits (70), Expect = 0.96
 Identities = 28/99 (28%), Positives = 45/99 (45%), Gaps = 25/99 (25%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEEL---------ILVHD 169
           LAA  G ++ L  L+++  +L +R    +G + L   A  G  E +         ILV D
Sbjct: 556 LAAYHGHHQALEVLVQSLLDLDVRNS--SGRTPLDLAAFKGHVECVDVLINQGASILVKD 613

Query: 170 FALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLVG 208
           + L+R              TP+H AA  GH   +++L+G
Sbjct: 614 YILKR--------------TPIHAAATNGHSECLRLLIG 638



 Score = 31.2 bits (69), Expect = 1.3
 Identities = 17/49 (34%), Positives = 26/49 (53%), Gaps = 1/49 (2%)

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHY 227
           +V+     G T LH AA  GH  ++K+L+ + GA+    D    RA H+
Sbjct: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLL-SRGANINAFDKKDRRAIHW 179



 Score = 31.2 bits (69), Expect = 1.3
 Identities = 30/108 (27%), Positives = 50/108 (46%), Gaps = 9/108 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           + A  GR+   + ++++    ++  +   G + LH  A++G HE LI   +  +  G   
Sbjct: 312 MTALHGRFSRSQTIIQSGA--VIDCEDKNGNTPLHIAARYG-HELLI---NTLITSGA-- 363

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACH 226
           D +  G  G+ PLHLAAL G     + L+ + G D    D  G    H
Sbjct: 364 DTAKRGIHGMFPLHLAALSGFSDCCRKLLSS-GFDIDTPDDFGRTCLH 410



 Score = 29.6 bits (65), Expect = 3.6
 Identities = 25/79 (31%), Positives = 38/79 (48%), Gaps = 7/79 (8%)

Query: 148 GYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           G + LH  A  G  E + L+    L RG   +++A        +H AA  GH  V+K+LV
Sbjct: 140 GRTALHHAAFSGHGEMVKLL----LSRGA--NINAFDKKDRRAIHWAAYMGHIEVVKLLV 193

Query: 208 GALGADATRRDHSGHRACH 226
            + GA+ T +D   +   H
Sbjct: 194 -SHGAEVTCKDKKSYTPLH 211



 Score = 29.6 bits (65), Expect = 3.6
 Identities = 32/108 (29%), Positives = 45/108 (41%), Gaps = 8/108 (7%)

Query: 120 AAAEGRYEVLRELL-EAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           AA  G  E LR L+  AEP+  +      G + L     +G H + +      L +G  +
Sbjct: 624 AATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNG-HTDCVYS---LLNKGANV 679

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACH 226
           D  A    G T LH  A+ GH+  +  L+   GA    RD  G    H
Sbjct: 680 D--AKDKWGRTALHRGAVTGHEECVDALL-QHGAKCLLRDSRGRTPIH 724



 Score = 29.3 bits (64), Expect = 4.8
 Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 8/108 (7%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           +A   G+  V+ EL++    +  + +   G++ LH+ A    H  L L     L  G   
Sbjct: 245 VACYNGQDVVVNELIDCGAIVNQKNEK--GFTPLHFAAA-STHGALCL----ELLVGNGA 297

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACH 226
           DV+     G TPLH+ AL G     + ++ + GA     D +G+   H
Sbjct: 298 DVNMKSKDGKTPLHMTALHGRFSRSQTIIQS-GAVIDCEDKNGNTPLH 344


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 36/112 (32%), Positives = 54/112 (48%), Gaps = 11/112 (9%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           +AA + + EV R LL+         + + G + LH  A+ G H E++     AL    + 
Sbjct: 641 IAAKQNQVEVARSLLQYGGSA--NAESVQGVTPLHLAAQEG-HAEMV-----ALLLSKQA 692

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV--GALGADATRRDHSG-HRACHY 227
           + +     GLTPLHL A +GH  V  VL+  G +    TR  ++  H A HY
Sbjct: 693 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY 744



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 31/91 (34%), Positives = 44/91 (48%), Gaps = 12/91 (13%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHG--RHEELILVHDFALRRGL 176
           +AA EG  E +  LLE E           G++ LH  AK+G  R  EL+L  D       
Sbjct: 542 IAAREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLLERD------- 592

Query: 177 RLDVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
               +A G  GLTPLH+A    +  ++K+L+
Sbjct: 593 -AHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622



 Score = 36.2 bits (82), Expect = 0.039
 Identities = 27/89 (30%), Positives = 46/89 (51%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           LA+ EG  +++ ELL  E  ++L      G + LH  A  G+ E +  + ++        
Sbjct: 84  LASKEGHVKMVVELLHKE--IILETTTKKGNTALHIAALAGQDEVVRELVNYGA------ 135

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           +V+A    G TPL++AA + H  V+K L+
Sbjct: 136 NVNAQSQKGFTPLYMAAQENHLEVVKFLL 164



 Score = 35.8 bits (81), Expect = 0.051
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           +AA  G + V + LL+   +   R   + G++ LH   K       + V +  L+ G  +
Sbjct: 377 VAAHCGHHRVAKVLLDKGAKPNSRA--LNGFTPLHIACKKNH----VRVMELLLKTGASI 430

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           D  A    GLTPLH+A+  GH  ++K L+
Sbjct: 431 D--AVTESGLTPLHVASFMGHLPIVKNLL 457



 Score = 34.3 bits (77), Expect = 0.15
 Identities = 23/75 (30%), Positives = 42/75 (56%), Gaps = 12/75 (16%)

Query: 139 LLLRGDPI------TGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLH 192
           +LL+ DP       TG++ LH  A    H E + V    L RG  ++ +     G+TPLH
Sbjct: 224 VLLQNDPNPDVLSKTGFTPLHIAA----HYENLNVAQLLLNRGASVNFTP--QNGITPLH 277

Query: 193 LAALQGHDMVIKVLV 207
           +A+ +G+ +++++L+
Sbjct: 278 IASRRGNVIMVRLLL 292



 Score = 33.5 bits (75), Expect = 0.25
 Identities = 27/89 (30%), Positives = 43/89 (48%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           +AA  G+ EV+REL+     +  +     G++ L+  A+    E    V  F L  G   
Sbjct: 117 IAALAGQDEVVRELVNYGANVNAQSQK--GFTPLYMAAQENHLE----VVKFLLENGANQ 170

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           +V+     G TPL +A  QGH+ V+  L+
Sbjct: 171 NVAT--EDGFTPLAVALQQGHENVVAHLI 197



 Score = 32.7 bits (73), Expect = 0.43
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           L A EG   V   L++    +++      GY+ LH  + +G     I +  F L+   + 
Sbjct: 707 LVAQEGHVPVADVLIKHG--VMVDATTRMGYTPLHVASHYGN----IKLVKFLLQH--QA 758

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           DV+A    G +PLH AA QGH  ++ +L+
Sbjct: 759 DVNAKTKLGYSPLHQAAQQGHTDIVTLLL 787



 Score = 29.6 bits (65), Expect = 3.6
 Identities = 18/63 (28%), Positives = 31/63 (49%), Gaps = 6/63 (9%)

Query: 145 PITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIK 204
           P  G + LH  ++ G     +++    L RG +++        LTPLH AA  GH  + +
Sbjct: 269 PQNGITPLHIASRRGN----VIMVRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISE 322

Query: 205 VLV 207
           +L+
Sbjct: 323 ILL 325



 Score = 29.6 bits (65), Expect = 3.6
 Identities = 34/96 (35%), Positives = 44/96 (45%), Gaps = 18/96 (18%)

Query: 139 LLLRGDPI-----TGYSVLHWLAKHGRHEE---LILVHDFALRRGLRLDVSAPGSGGLTP 190
           LL  G PI      G S +H +A  G H +   L+L +D  +   + LD        LTP
Sbjct: 324 LLDHGAPIQAKTKNGLSPIH-MAAQGDHLDCVRLLLQYDAEID-DITLD-------HLTP 374

Query: 191 LHLAALQGHDMVIKVLVGALGADATRRDHSGHRACH 226
           LH+AA  GH  V KVL+   GA    R  +G    H
Sbjct: 375 LHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLH 409



 Score = 28.5 bits (62), Expect = 8.1
 Identities = 26/90 (28%), Positives = 43/90 (47%), Gaps = 14/90 (15%)

Query: 172 LRRGLRLDVSAPGSGGLTPLHLAALQGH-DMVIKVLVGALGADATRRDHSGHRACHYLRP 230
           LR G+  D++     GL  LHLA+ +GH  MV+++L   +  + T +   G+ A H    
Sbjct: 65  LRNGV--DINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK--KGNTALH---- 116

Query: 231 DAPWRLRELSGAEEWEMESGSGCTNLNNNS 260
                +  L+G +E   E  +   N+N  S
Sbjct: 117 -----IAALAGQDEVVRELVNYGANVNAQS 141


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 36/112 (32%), Positives = 54/112 (48%), Gaps = 11/112 (9%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           +AA + + EV R LL+         + + G + LH  A+ G H E++     AL    + 
Sbjct: 608 IAAKQNQVEVARSLLQYGGSA--NAESVQGVTPLHLAAQEG-HAEMV-----ALLLSKQA 659

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV--GALGADATRRDHSG-HRACHY 227
           + +     GLTPLHL A +GH  V  VL+  G +    TR  ++  H A HY
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY 711



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 31/91 (34%), Positives = 44/91 (48%), Gaps = 12/91 (13%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHG--RHEELILVHDFALRRGL 176
           +AA EG  E +  LLE E           G++ LH  AK+G  R  EL+L  D       
Sbjct: 509 IAAREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLLERD------- 559

Query: 177 RLDVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
               +A G  GLTPLH+A    +  ++K+L+
Sbjct: 560 -AHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589



 Score = 36.2 bits (82), Expect = 0.039
 Identities = 27/89 (30%), Positives = 46/89 (51%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           LA+ EG  +++ ELL  E  ++L      G + LH  A  G+ E +  + ++        
Sbjct: 51  LASKEGHVKMVVELLHKE--IILETTTKKGNTALHIAALAGQDEVVRELVNYGA------ 102

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           +V+A    G TPL++AA + H  V+K L+
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLL 131



 Score = 35.8 bits (81), Expect = 0.051
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           +AA  G + V + LL+   +   R   + G++ LH   K       + V +  L+ G  +
Sbjct: 344 VAAHCGHHRVAKVLLDKGAKPNSRA--LNGFTPLHIACKKNH----VRVMELLLKTGASI 397

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           D  A    GLTPLH+A+  GH  ++K L+
Sbjct: 398 D--AVTESGLTPLHVASFMGHLPIVKNLL 424



 Score = 34.3 bits (77), Expect = 0.15
 Identities = 23/75 (30%), Positives = 42/75 (56%), Gaps = 12/75 (16%)

Query: 139 LLLRGDPI------TGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLH 192
           +LL+ DP       TG++ LH  A    H E + V    L RG  ++ +     G+TPLH
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAA----HYENLNVAQLLLNRGASVNFTP--QNGITPLH 244

Query: 193 LAALQGHDMVIKVLV 207
           +A+ +G+ +++++L+
Sbjct: 245 IASRRGNVIMVRLLL 259



 Score = 33.5 bits (75), Expect = 0.25
 Identities = 27/89 (30%), Positives = 43/89 (48%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           +AA  G+ EV+REL+     +  +     G++ L+  A+    E    V  F L  G   
Sbjct: 84  IAALAGQDEVVRELVNYGANVNAQSQK--GFTPLYMAAQENHLE----VVKFLLENGANQ 137

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           +V+     G TPL +A  QGH+ V+  L+
Sbjct: 138 NVAT--EDGFTPLAVALQQGHENVVAHLI 164



 Score = 32.7 bits (73), Expect = 0.43
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           L A EG   V   L++    +++      GY+ LH  + +G     I +  F L+   + 
Sbjct: 674 LVAQEGHVPVADVLIKHG--VMVDATTRMGYTPLHVASHYGN----IKLVKFLLQH--QA 725

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           DV+A    G +PLH AA QGH  ++ +L+
Sbjct: 726 DVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754



 Score = 29.6 bits (65), Expect = 3.6
 Identities = 18/63 (28%), Positives = 31/63 (49%), Gaps = 6/63 (9%)

Query: 145 PITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIK 204
           P  G + LH  ++ G     +++    L RG +++        LTPLH AA  GH  + +
Sbjct: 236 PQNGITPLHIASRRGN----VIMVRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISE 289

Query: 205 VLV 207
           +L+
Sbjct: 290 ILL 292



 Score = 29.6 bits (65), Expect = 3.6
 Identities = 34/96 (35%), Positives = 44/96 (45%), Gaps = 18/96 (18%)

Query: 139 LLLRGDPI-----TGYSVLHWLAKHGRHEE---LILVHDFALRRGLRLDVSAPGSGGLTP 190
           LL  G PI      G S +H +A  G H +   L+L +D  +   + LD        LTP
Sbjct: 291 LLDHGAPIQAKTKNGLSPIH-MAAQGDHLDCVRLLLQYDAEID-DITLD-------HLTP 341

Query: 191 LHLAALQGHDMVIKVLVGALGADATRRDHSGHRACH 226
           LH+AA  GH  V KVL+   GA    R  +G    H
Sbjct: 342 LHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLH 376



 Score = 28.5 bits (62), Expect = 8.1
 Identities = 26/90 (28%), Positives = 43/90 (47%), Gaps = 14/90 (15%)

Query: 172 LRRGLRLDVSAPGSGGLTPLHLAALQGH-DMVIKVLVGALGADATRRDHSGHRACHYLRP 230
           LR G+  D++     GL  LHLA+ +GH  MV+++L   +  + T +   G+ A H    
Sbjct: 32  LRNGV--DINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK--KGNTALH---- 83

Query: 231 DAPWRLRELSGAEEWEMESGSGCTNLNNNS 260
                +  L+G +E   E  +   N+N  S
Sbjct: 84  -----IAALAGQDEVVRELVNYGANVNAQS 108


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 36/112 (32%), Positives = 54/112 (48%), Gaps = 11/112 (9%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           +AA + + EV R LL+         + + G + LH  A+ G H E++     AL    + 
Sbjct: 608 IAAKQNQVEVARSLLQYGGSA--NAESVQGVTPLHLAAQEG-HAEMV-----ALLLSKQA 659

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV--GALGADATRRDHSG-HRACHY 227
           + +     GLTPLHL A +GH  V  VL+  G +    TR  ++  H A HY
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY 711



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 31/91 (34%), Positives = 44/91 (48%), Gaps = 12/91 (13%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHG--RHEELILVHDFALRRGL 176
           +AA EG  E +  LLE E           G++ LH  AK+G  R  EL+L  D       
Sbjct: 509 IAAREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLLERD------- 559

Query: 177 RLDVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
               +A G  GLTPLH+A    +  ++K+L+
Sbjct: 560 -AHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589



 Score = 36.2 bits (82), Expect = 0.039
 Identities = 27/89 (30%), Positives = 46/89 (51%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           LA+ EG  +++ ELL  E  ++L      G + LH  A  G+ E +  + ++        
Sbjct: 51  LASKEGHVKMVVELLHKE--IILETTTKKGNTALHIAALAGQDEVVRELVNYGA------ 102

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           +V+A    G TPL++AA + H  V+K L+
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLL 131



 Score = 35.8 bits (81), Expect = 0.051
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           +AA  G + V + LL+   +   R   + G++ LH   K       + V +  L+ G  +
Sbjct: 344 VAAHCGHHRVAKVLLDKGAKPNSRA--LNGFTPLHIACKKNH----VRVMELLLKTGASI 397

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           D  A    GLTPLH+A+  GH  ++K L+
Sbjct: 398 D--AVTESGLTPLHVASFMGHLPIVKNLL 424



 Score = 34.3 bits (77), Expect = 0.15
 Identities = 23/75 (30%), Positives = 42/75 (56%), Gaps = 12/75 (16%)

Query: 139 LLLRGDPI------TGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLH 192
           +LL+ DP       TG++ LH  A    H E + V    L RG  ++ +     G+TPLH
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAA----HYENLNVAQLLLNRGASVNFTP--QNGITPLH 244

Query: 193 LAALQGHDMVIKVLV 207
           +A+ +G+ +++++L+
Sbjct: 245 IASRRGNVIMVRLLL 259



 Score = 33.5 bits (75), Expect = 0.25
 Identities = 27/89 (30%), Positives = 43/89 (48%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           +AA  G+ EV+REL+     +  +     G++ L+  A+    E    V  F L  G   
Sbjct: 84  IAALAGQDEVVRELVNYGANVNAQSQK--GFTPLYMAAQENHLE----VVKFLLENGANQ 137

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           +V+     G TPL +A  QGH+ V+  L+
Sbjct: 138 NVAT--EDGFTPLAVALQQGHENVVAHLI 164



 Score = 32.7 bits (73), Expect = 0.43
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           L A EG   V   L++    +++      GY+ LH  + +G     I +  F L+   + 
Sbjct: 674 LVAQEGHVPVADVLIKHG--VMVDATTRMGYTPLHVASHYGN----IKLVKFLLQH--QA 725

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           DV+A    G +PLH AA QGH  ++ +L+
Sbjct: 726 DVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754



 Score = 29.6 bits (65), Expect = 3.6
 Identities = 18/63 (28%), Positives = 31/63 (49%), Gaps = 6/63 (9%)

Query: 145 PITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIK 204
           P  G + LH  ++ G     +++    L RG +++        LTPLH AA  GH  + +
Sbjct: 236 PQNGITPLHIASRRGN----VIMVRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISE 289

Query: 205 VLV 207
           +L+
Sbjct: 290 ILL 292



 Score = 29.6 bits (65), Expect = 3.6
 Identities = 34/96 (35%), Positives = 44/96 (45%), Gaps = 18/96 (18%)

Query: 139 LLLRGDPI-----TGYSVLHWLAKHGRHEE---LILVHDFALRRGLRLDVSAPGSGGLTP 190
           LL  G PI      G S +H +A  G H +   L+L +D  +   + LD        LTP
Sbjct: 291 LLDHGAPIQAKTKNGLSPIH-MAAQGDHLDCVRLLLQYDAEID-DITLD-------HLTP 341

Query: 191 LHLAALQGHDMVIKVLVGALGADATRRDHSGHRACH 226
           LH+AA  GH  V KVL+   GA    R  +G    H
Sbjct: 342 LHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLH 376



 Score = 28.5 bits (62), Expect = 8.1
 Identities = 26/90 (28%), Positives = 43/90 (47%), Gaps = 14/90 (15%)

Query: 172 LRRGLRLDVSAPGSGGLTPLHLAALQGH-DMVIKVLVGALGADATRRDHSGHRACHYLRP 230
           LR G+  D++     GL  LHLA+ +GH  MV+++L   +  + T +   G+ A H    
Sbjct: 32  LRNGV--DINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK--KGNTALH---- 83

Query: 231 DAPWRLRELSGAEEWEMESGSGCTNLNNNS 260
                +  L+G +E   E  +   N+N  S
Sbjct: 84  -----IAALAGQDEVVRELVNYGANVNAQS 108


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 36/112 (32%), Positives = 54/112 (48%), Gaps = 11/112 (9%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           +AA + + EV R LL+         + + G + LH  A+ G H E++     AL    + 
Sbjct: 608 IAAKQNQVEVARSLLQYGGSA--NAESVQGVTPLHLAAQEG-HAEMV-----ALLLSKQA 659

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV--GALGADATRRDHSG-HRACHY 227
           + +     GLTPLHL A +GH  V  VL+  G +    TR  ++  H A HY
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY 711



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 31/91 (34%), Positives = 44/91 (48%), Gaps = 12/91 (13%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHG--RHEELILVHDFALRRGL 176
           +AA EG  E +  LLE E           G++ LH  AK+G  R  EL+L  D       
Sbjct: 509 IAAREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLLERD------- 559

Query: 177 RLDVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
               +A G  GLTPLH+A    +  ++K+L+
Sbjct: 560 -AHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589



 Score = 36.2 bits (82), Expect = 0.039
 Identities = 27/89 (30%), Positives = 46/89 (51%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           LA+ EG  +++ ELL  E  ++L      G + LH  A  G+ E +  + ++        
Sbjct: 51  LASKEGHVKMVVELLHKE--IILETTTKKGNTALHIAALAGQDEVVRELVNYGA------ 102

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           +V+A    G TPL++AA + H  V+K L+
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLL 131



 Score = 35.8 bits (81), Expect = 0.051
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           +AA  G + V + LL+   +   R   + G++ LH   K       + V +  L+ G  +
Sbjct: 344 VAAHCGHHRVAKVLLDKGAKPNSRA--LNGFTPLHIACKKNH----VRVMELLLKTGASI 397

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           D  A    GLTPLH+A+  GH  ++K L+
Sbjct: 398 D--AVTESGLTPLHVASFMGHLPIVKNLL 424



 Score = 34.3 bits (77), Expect = 0.15
 Identities = 23/75 (30%), Positives = 42/75 (56%), Gaps = 12/75 (16%)

Query: 139 LLLRGDPI------TGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLH 192
           +LL+ DP       TG++ LH  A    H E + V    L RG  ++ +     G+TPLH
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAA----HYENLNVAQLLLNRGASVNFTP--QNGITPLH 244

Query: 193 LAALQGHDMVIKVLV 207
           +A+ +G+ +++++L+
Sbjct: 245 IASRRGNVIMVRLLL 259



 Score = 33.5 bits (75), Expect = 0.25
 Identities = 27/89 (30%), Positives = 43/89 (48%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           +AA  G+ EV+REL+     +  +     G++ L+  A+    E    V  F L  G   
Sbjct: 84  IAALAGQDEVVRELVNYGANVNAQSQK--GFTPLYMAAQENHLE----VVKFLLENGANQ 137

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           +V+     G TPL +A  QGH+ V+  L+
Sbjct: 138 NVAT--EDGFTPLAVALQQGHENVVAHLI 164



 Score = 32.7 bits (73), Expect = 0.43
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           L A EG   V   L++    +++      GY+ LH  + +G     I +  F L+   + 
Sbjct: 674 LVAQEGHVPVADVLIKHG--VMVDATTRMGYTPLHVASHYGN----IKLVKFLLQH--QA 725

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           DV+A    G +PLH AA QGH  ++ +L+
Sbjct: 726 DVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754



 Score = 29.6 bits (65), Expect = 3.6
 Identities = 18/63 (28%), Positives = 31/63 (49%), Gaps = 6/63 (9%)

Query: 145 PITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIK 204
           P  G + LH  ++ G     +++    L RG +++        LTPLH AA  GH  + +
Sbjct: 236 PQNGITPLHIASRRGN----VIMVRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISE 289

Query: 205 VLV 207
           +L+
Sbjct: 290 ILL 292



 Score = 29.6 bits (65), Expect = 3.6
 Identities = 34/96 (35%), Positives = 44/96 (45%), Gaps = 18/96 (18%)

Query: 139 LLLRGDPI-----TGYSVLHWLAKHGRHEE---LILVHDFALRRGLRLDVSAPGSGGLTP 190
           LL  G PI      G S +H +A  G H +   L+L +D  +   + LD        LTP
Sbjct: 291 LLDHGAPIQAKTKNGLSPIH-MAAQGDHLDCVRLLLQYDAEID-DITLD-------HLTP 341

Query: 191 LHLAALQGHDMVIKVLVGALGADATRRDHSGHRACH 226
           LH+AA  GH  V KVL+   GA    R  +G    H
Sbjct: 342 LHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLH 376



 Score = 28.5 bits (62), Expect = 8.1
 Identities = 26/90 (28%), Positives = 43/90 (47%), Gaps = 14/90 (15%)

Query: 172 LRRGLRLDVSAPGSGGLTPLHLAALQGH-DMVIKVLVGALGADATRRDHSGHRACHYLRP 230
           LR G+  D++     GL  LHLA+ +GH  MV+++L   +  + T +   G+ A H    
Sbjct: 32  LRNGV--DINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK--KGNTALH---- 83

Query: 231 DAPWRLRELSGAEEWEMESGSGCTNLNNNS 260
                +  L+G +E   E  +   N+N  S
Sbjct: 84  -----IAALAGQDEVVRELVNYGANVNAQS 108


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 36/112 (32%), Positives = 54/112 (48%), Gaps = 11/112 (9%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           +AA + + EV R LL+         + + G + LH  A+ G H E++     AL    + 
Sbjct: 608 IAAKQNQVEVARSLLQYGGSA--NAESVQGVTPLHLAAQEG-HAEMV-----ALLLSKQA 659

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV--GALGADATRRDHSG-HRACHY 227
           + +     GLTPLHL A +GH  V  VL+  G +    TR  ++  H A HY
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY 711



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 31/91 (34%), Positives = 44/91 (48%), Gaps = 12/91 (13%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHG--RHEELILVHDFALRRGL 176
           +AA EG  E +  LLE E           G++ LH  AK+G  R  EL+L  D       
Sbjct: 509 IAAREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLLERD------- 559

Query: 177 RLDVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
               +A G  GLTPLH+A    +  ++K+L+
Sbjct: 560 -AHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589



 Score = 36.2 bits (82), Expect = 0.039
 Identities = 27/89 (30%), Positives = 46/89 (51%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           LA+ EG  +++ ELL  E  ++L      G + LH  A  G+ E +  + ++        
Sbjct: 51  LASKEGHVKMVVELLHKE--IILETTTKKGNTALHIAALAGQDEVVRELVNYGA------ 102

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           +V+A    G TPL++AA + H  V+K L+
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLL 131



 Score = 35.8 bits (81), Expect = 0.051
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           +AA  G + V + LL+   +   R   + G++ LH   K       + V +  L+ G  +
Sbjct: 344 VAAHCGHHRVAKVLLDKGAKPNSRA--LNGFTPLHIACKKNH----VRVMELLLKTGASI 397

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           D  A    GLTPLH+A+  GH  ++K L+
Sbjct: 398 D--AVTESGLTPLHVASFMGHLPIVKNLL 424



 Score = 34.3 bits (77), Expect = 0.15
 Identities = 23/75 (30%), Positives = 42/75 (56%), Gaps = 12/75 (16%)

Query: 139 LLLRGDPI------TGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLH 192
           +LL+ DP       TG++ LH  A    H E + V    L RG  ++ +     G+TPLH
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAA----HYENLNVAQLLLNRGASVNFTP--QNGITPLH 244

Query: 193 LAALQGHDMVIKVLV 207
           +A+ +G+ +++++L+
Sbjct: 245 IASRRGNVIMVRLLL 259



 Score = 33.5 bits (75), Expect = 0.25
 Identities = 27/89 (30%), Positives = 43/89 (48%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           +AA  G+ EV+REL+     +  +     G++ L+  A+    E    V  F L  G   
Sbjct: 84  IAALAGQDEVVRELVNYGANVNAQSQK--GFTPLYMAAQENHLE----VVKFLLENGANQ 137

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           +V+     G TPL +A  QGH+ V+  L+
Sbjct: 138 NVAT--EDGFTPLAVALQQGHENVVAHLI 164



 Score = 32.7 bits (73), Expect = 0.43
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 8/89 (8%)

Query: 119 LAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           L A EG   V   L++    +++      GY+ LH  + +G     I +  F L+   + 
Sbjct: 674 LVAQEGHVPVADVLIKHG--VMVDATTRMGYTPLHVASHYGN----IKLVKFLLQH--QA 725

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
           DV+A    G +PLH AA QGH  ++ +L+
Sbjct: 726 DVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754



 Score = 29.6 bits (65), Expect = 3.6
 Identities = 18/63 (28%), Positives = 31/63 (49%), Gaps = 6/63 (9%)

Query: 145 PITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIK 204
           P  G + LH  ++ G     +++    L RG +++        LTPLH AA  GH  + +
Sbjct: 236 PQNGITPLHIASRRGN----VIMVRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISE 289

Query: 205 VLV 207
           +L+
Sbjct: 290 ILL 292



 Score = 29.6 bits (65), Expect = 3.6
 Identities = 34/96 (35%), Positives = 44/96 (45%), Gaps = 18/96 (18%)

Query: 139 LLLRGDPI-----TGYSVLHWLAKHGRHEE---LILVHDFALRRGLRLDVSAPGSGGLTP 190
           LL  G PI      G S +H +A  G H +   L+L +D  +   + LD        LTP
Sbjct: 291 LLDHGAPIQAKTKNGLSPIH-MAAQGDHLDCVRLLLQYDAEID-DITLD-------HLTP 341

Query: 191 LHLAALQGHDMVIKVLVGALGADATRRDHSGHRACH 226
           LH+AA  GH  V KVL+   GA    R  +G    H
Sbjct: 342 LHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLH 376



 Score = 28.5 bits (62), Expect = 8.1
 Identities = 26/90 (28%), Positives = 43/90 (47%), Gaps = 14/90 (15%)

Query: 172 LRRGLRLDVSAPGSGGLTPLHLAALQGH-DMVIKVLVGALGADATRRDHSGHRACHYLRP 230
           LR G+  D++     GL  LHLA+ +GH  MV+++L   +  + T +   G+ A H    
Sbjct: 32  LRNGV--DINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK--KGNTALH---- 83

Query: 231 DAPWRLRELSGAEEWEMESGSGCTNLNNNS 260
                +  L+G +E   E  +   N+N  S
Sbjct: 84  -----IAALAGQDEVVRELVNYGANVNAQS 108


>gi|124517699 ankyrin repeat domain 13B [Homo sapiens]
          Length = 626

 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 29/70 (41%), Positives = 38/70 (54%), Gaps = 6/70 (8%)

Query: 152 LHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLVGALG 211
           LH+L  H RH EL    +  +R G ++D+      G TPLHLA   GH    +VL+ A G
Sbjct: 18  LHYLVWHNRHREL----EKEVRAG-QVDIEQLDPRGRTPLHLATTLGHLECARVLL-AHG 71

Query: 212 ADATRRDHSG 221
           AD  R + SG
Sbjct: 72  ADVGRENRSG 81


>gi|70995241 ankyrin repeat domain 10 [Homo sapiens]
          Length = 420

 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 34/108 (31%), Positives = 49/108 (45%), Gaps = 7/108 (6%)

Query: 120 AAAEGRYEVLRELLEAEPELLLRG-DPITGYSVLHWLAKHGRHEELILVHDFALRRGLRL 178
           A  +G    L  LL+  P   L   D   G++ +HW A  G+ E L+ +    +R G  L
Sbjct: 29  ACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQL----VRAGATL 84

Query: 179 DVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACH 226
           +VS       TP H+AA  GH   +  L+ A GA+  + D  G    H
Sbjct: 85  NVSTTRYAQ-TPAHIAAFGGHPQCLVWLIQA-GANINKPDCEGETPIH 130


>gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens]
          Length = 361

 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 37/104 (35%), Positives = 50/104 (48%), Gaps = 8/104 (7%)

Query: 124 GRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEEL-ILVHDFALRRGLRLDVSA 182
           G  +V R LL+     L   D + G   LH  A  G+ E +  LV +     G+ +DV A
Sbjct: 216 GHIDVARLLLDEHGACLSAEDSL-GAQALHRAAVTGQDEAIRFLVSEL----GVDVDVRA 270

Query: 183 PGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACH 226
             S  LT LH AA +GH   I+ L+ +LGAD   +D     A H
Sbjct: 271 T-STHLTALHYAAKEGHTSTIQTLL-SLGADINSKDEKNRSALH 312



 Score = 36.6 bits (83), Expect = 0.030
 Identities = 26/66 (39%), Positives = 30/66 (45%), Gaps = 11/66 (16%)

Query: 171 ALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGAD--ATRRDHS-------- 220
           AL+  L+     PG  G T LH AA  GH  V+  L  A G D  AT RD+         
Sbjct: 21  ALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAAS 80

Query: 221 -GHRAC 225
            GHR C
Sbjct: 81  MGHRDC 86



 Score = 35.8 bits (81), Expect = 0.051
 Identities = 47/184 (25%), Positives = 74/184 (40%), Gaps = 35/184 (19%)

Query: 39  LGRYWGKAAAAASREHPFPGTLMHSAAGSGRRRGALRELLGLQRAAPAGWLSEERAEELG 98
           L   WG    A +R++  P   +H AA  G R   +R LLG                   
Sbjct: 56  LAEAWGMDIEATNRDYKRP---LHEAASMGHR-DCVRYLLGR------------------ 93

Query: 99  GPSGPGSSRLCLEPREHA-WILAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAK 157
                G++  CL+  +    ++A       V++EL+E     LL+     G++  H  ++
Sbjct: 94  -----GAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKD--GWNSFHIASR 146

Query: 158 HGRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRR 217
            G  + LIL +   +  G     S       TPLH AA+ GH   +KVL+     +   R
Sbjct: 147 EG--DPLILQYLLTVCPGAWKTESKIRR---TPLHTAAMHGHLEAVKVLLKRCQYEPDYR 201

Query: 218 DHSG 221
           D+ G
Sbjct: 202 DNCG 205



 Score = 34.7 bits (78), Expect = 0.11
 Identities = 22/49 (44%), Positives = 25/49 (51%), Gaps = 1/49 (2%)

Query: 180 VSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGH-RACHY 227
           +SA  S G   LH AA+ G D  I+ LV  LG D   R  S H  A HY
Sbjct: 232 LSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHY 280


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.131    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,416,596
Number of Sequences: 37866
Number of extensions: 671609
Number of successful extensions: 3426
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 75
Number of HSP's successfully gapped in prelim test: 170
Number of HSP's that attempted gapping in prelim test: 2713
Number of HSP's gapped (non-prelim): 734
length of query: 315
length of database: 18,247,518
effective HSP length: 102
effective length of query: 213
effective length of database: 14,385,186
effective search space: 3064044618
effective search space used: 3064044618
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.