Guide to the Human Genome
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Search of human proteins with 157738619

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157738619 smoothelin-like 1 [Homo sapiens]
         (512 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157738619 smoothelin-like 1 [Homo sapiens]                        1020   0.0  
gi|19913396 smoothelin isoform b [Homo sapiens]                       204   1e-52
gi|19913394 smoothelin isoform c [Homo sapiens]                       173   4e-43
gi|19913398 smoothelin isoform a [Homo sapiens]                       169   6e-42
gi|169234649 smoothelin-like 2 isoform 2 [Homo sapiens]               164   2e-40
gi|169234647 smoothelin-like 2 isoform 1 [Homo sapiens]               164   2e-40
gi|150378549 tangerin [Homo sapiens]                                  108   9e-24
gi|224451082 cytospin A [Homo sapiens]                                107   3e-23
gi|224451080 cytospin A [Homo sapiens]                                107   3e-23
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    97   3e-20
gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo sa...    97   5e-20
gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo sa...    97   5e-20
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     94   3e-19
gi|217330568 EH domain binding protein 1 isoform 1 [Homo sapiens]      93   5e-19
gi|4557241 actinin, alpha 3 [Homo sapiens]                             93   7e-19
gi|217330574 EH domain binding protein 1 isoform 3 [Homo sapiens]      93   7e-19
gi|217330572 EH domain binding protein 1 isoform 3 [Homo sapiens]      93   7e-19
gi|217330570 EH domain binding protein 1 isoform 2 [Homo sapiens]      93   7e-19
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]                 93   7e-19
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]                 93   7e-19
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]                   93   7e-19
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    92   9e-19
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    92   9e-19
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]         91   3e-18
gi|4501893 actinin, alpha 2 [Homo sapiens]                             89   1e-17
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [...    88   2e-17
gi|67782321 spectrin beta isoform a [Homo sapiens]                     87   3e-17
gi|67782319 spectrin beta isoform b [Homo sapiens]                     87   3e-17
gi|12025678 actinin, alpha 4 [Homo sapiens]                            87   5e-17
gi|31324577 molecule interacting with Rab13 [Homo sapiens]             86   6e-17

>gi|157738619 smoothelin-like 1 [Homo sapiens]
          Length = 512

 Score = 1020 bits (2637), Expect = 0.0
 Identities = 512/512 (100%), Positives = 512/512 (100%)

Query: 1   MLPGAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAI 60
           MLPGAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAI
Sbjct: 1   MLPGAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAI 60

Query: 61  NEGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKE 120
           NEGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKE
Sbjct: 61  NEGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKE 120

Query: 121 ETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEP 180
           ETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEP
Sbjct: 121 ETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEP 180

Query: 181 KATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKE 240
           KATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKE
Sbjct: 181 KATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKE 240

Query: 241 EAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGE 300
           EAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGE
Sbjct: 241 EAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGE 300

Query: 301 GHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPR 360
           GHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPR
Sbjct: 301 GHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPR 360

Query: 361 GPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQN 420
           GPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQN
Sbjct: 361 GPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQN 420

Query: 421 FSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMV 480
           FSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMV
Sbjct: 421 FSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMV 480

Query: 481 RLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK 512
           RLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK
Sbjct: 481 RLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK 512


>gi|19913396 smoothelin isoform b [Homo sapiens]
          Length = 915

 Score =  204 bits (520), Expect = 1e-52
 Identities = 133/388 (34%), Positives = 196/388 (50%), Gaps = 40/388 (10%)

Query: 149 TLASEKQKAEEKEAKPESGQKADANDRDK-PEPKATVEEEDAKTASQEETGQRKECSTEP 207
           ++  E + AE   A  E+   A+    +K PE ++ +  E+  T   E            
Sbjct: 542 SIKMEAEPAEPLAAAVEAANGAEQTRVNKAPEGRSPLSAEELMTIEDEGV---------- 591

Query: 208 KEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSP 267
            +K  D+    E +K +     +   ++ D +++ +    +EA  +       E    + 
Sbjct: 592 LDKMLDQSTDFEERKLIRAALRELRQRKRDQRDKERERRLQEARGRPG-----EGRGNTA 646

Query: 268 SEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLST-----------DGLGPDCVAS 316
           +E   +  ++  +G A    +  E    S  G     +T           +G G   + +
Sbjct: 647 TETTTRHSQRAADGSAVSTVTKTERLVHSNDGTRTARTTTVESSFVRRSENGSGSTMMQT 706

Query: 317 GQTSPSASESSPSDV----PQSPPESPSSGEKKEKAPERR---VSAPARPRGPRAQNRKA 369
              S S+S      +     Q+ P + S    +++  E++   + A + P+   +Q RKA
Sbjct: 707 KTFSSSSSSKKMGSIFDREDQASPRAGSLAALEKRQAEKKKELMKAQSLPKTSASQARKA 766

Query: 370 IVDKF-----GGAASGPTALFRNTKAAGAA-IGGVKNMLLEWCRAMTKKYEHVDIQNFSS 423
           +++K       G+  GP A  + + + G      +K MLL+WCRA T+ YEHVDIQNFSS
Sbjct: 767 MIEKLEKEGAAGSPGGPRAAVQRSTSFGVPNANSIKQMLLDWCRAKTRGYEHVDIQNFSS 826

Query: 424 SWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLA 483
           SWS GMAFCAL+H FFP+AFDY +L P  RR NF +AFS+AE  ADC QLLD +DMVRL 
Sbjct: 827 SWSDGMAFCALVHNFFPEAFDYGQLSPQNRRQNFEVAFSSAETHADCPQLLDTEDMVRLR 886

Query: 484 VPDSKCVYTYIQELYRSLVQKGLVKTKK 511
            PD KCVYTYIQE YR LVQKGLVKTKK
Sbjct: 887 EPDWKCVYTYIQEFYRCLVQKGLVKTKK 914



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 69/301 (22%), Positives = 108/301 (35%), Gaps = 62/301 (20%)

Query: 111 ELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPE-SGQK 169
           EL++++ E+EE  + S+     +++ K         E+ L S++++AE++ A    +GQ 
Sbjct: 36  ELQRQELEREEEALASKRFRAERQDNK---------ENWLHSQQREAEQRAALARLAGQL 86

Query: 170 ADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEA 229
              ND         VEE  A   S  E  +RK        +A     +A+  +A      
Sbjct: 87  ESMND---------VEELTALLRSAGEYEERKLI------RAAIRRVRAQEIEAATLAGR 131

Query: 230 KAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSS 289
               +   G  E   G      A    E  E  E     EEQEQ  E           S 
Sbjct: 132 LYSGRPNSGSREDSKGL-----AAHRLEQCEVPE----REEQEQQAEV----------SK 172

Query: 290 PEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGE------ 343
           P   PE  + +   ++     P    S  +SP++  SSP+     PP  P+  +      
Sbjct: 173 PTPTPEGTSQDVTTVTLLLRAPP--GSTSSSPASPSSSPTPASPEPPLEPAEAQCLTAEV 230

Query: 344 ----------KKEKAPERRVSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGA 393
                      K  +PE + S        +  N+     K   AA  PT    +TK A  
Sbjct: 231 PGSPEPPPSPPKTTSPEPQESPTLPSTEGQVVNKLLSGPKETPAAQSPTRGPSDTKRADV 290

Query: 394 A 394
           A
Sbjct: 291 A 291


>gi|19913394 smoothelin isoform c [Homo sapiens]
          Length = 917

 Score =  173 bits (438), Expect = 4e-43
 Identities = 116/379 (30%), Positives = 184/379 (48%), Gaps = 41/379 (10%)

Query: 149 TLASEKQKAEEKEAKPESGQKADANDRDK-PEPKATVEEEDAKTASQEETGQRKECSTEP 207
           ++  E + AE   A  E+   A+    +K PE ++ +  E+  T   E            
Sbjct: 542 SIKMEAEPAEPLAAAVEAANGAEQTRVNKAPEGRSPLSAEELMTIEDEGV---------- 591

Query: 208 KEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSP 267
            +K  D+    E +K +     +   ++ D +++ +    +EA  +       E    + 
Sbjct: 592 LDKMLDQSTDFEERKLIRAALRELRQRKRDQRDKERERRLQEARGRPG-----EGRGNTA 646

Query: 268 SEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLST-----------DGLGPDCVAS 316
           +E   +  ++  +G A    +  E    S  G     +T           +G G   + +
Sbjct: 647 TETTTRHSQRAADGSAVSTVTKTERLVHSNDGTRTARTTTVESSFVRRSENGSGSTMMQT 706

Query: 317 GQTSPSASESSPSDV----PQSPPESPSSGEKKEKAPERR---VSAPARPRGPRAQNRKA 369
              S S+S      +     Q+ P + S    +++  E++   + A + P+   +Q RKA
Sbjct: 707 KTFSSSSSSKKMGSIFDREDQASPRAGSLAALEKRQAEKKKELMKAQSLPKTSASQARKA 766

Query: 370 IVDKF-----GGAASGPTALFRNTKAAGAA-IGGVKNMLLEWCRAMTKKYEHVDIQNFSS 423
           +++K       G+  GP A  + + + G      +K MLL+WCRA T+ YEHVDIQNFSS
Sbjct: 767 MIEKLEKEGAAGSPGGPRAAVQRSTSFGVPNANSIKQMLLDWCRAKTRGYEHVDIQNFSS 826

Query: 424 SWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLA 483
           SWS GMAFCAL+H FFP+AFDY +L P  RR NF +AFS+AE L DC  L++VDDM+ + 
Sbjct: 827 SWSDGMAFCALVHNFFPEAFDYGQLSPQNRRQNFEVAFSSAEMLVDCVPLVEVDDMMIMG 886

Query: 484 -VPDSKCVYTYIQELYRSL 501
             PD KCV+TY+Q LY  L
Sbjct: 887 KKPDPKCVFTYVQSLYNHL 905



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 69/301 (22%), Positives = 108/301 (35%), Gaps = 62/301 (20%)

Query: 111 ELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPE-SGQK 169
           EL++++ E+EE  + S+     +++ K         E+ L S++++AE++ A    +GQ 
Sbjct: 36  ELQRQELEREEEALASKRFRAERQDNK---------ENWLHSQQREAEQRAALARLAGQL 86

Query: 170 ADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEA 229
              ND         VEE  A   S  E  +RK        +A     +A+  +A      
Sbjct: 87  ESMND---------VEELTALLRSAGEYEERKLI------RAAIRRVRAQEIEAATLAGR 131

Query: 230 KAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSS 289
               +   G  E   G      A    E  E  E     EEQEQ  E           S 
Sbjct: 132 LYSGRPNSGSREDSKGL-----AAHRLEQCEVPE----REEQEQQAEV----------SK 172

Query: 290 PEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGE------ 343
           P   PE  + +   ++     P    S  +SP++  SSP+     PP  P+  +      
Sbjct: 173 PTPTPEGTSQDVTTVTLLLRAPP--GSTSSSPASPSSSPTPASPEPPLEPAEAQCLTAEV 230

Query: 344 ----------KKEKAPERRVSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGA 393
                      K  +PE + S        +  N+     K   AA  PT    +TK A  
Sbjct: 231 PGSPEPPPSPPKTTSPEPQESPTLPSTEGQVVNKLLSGPKETPAAQSPTRGPSDTKRADV 290

Query: 394 A 394
           A
Sbjct: 291 A 291


>gi|19913398 smoothelin isoform a [Homo sapiens]
          Length = 940

 Score =  169 bits (428), Expect = 6e-42
 Identities = 120/402 (29%), Positives = 185/402 (46%), Gaps = 64/402 (15%)

Query: 149 TLASEKQKAEEKEAKPESGQKADANDRDK-PEPKATVEEEDAKTASQEETGQRKECSTEP 207
           ++  E + AE   A  E+   A+    +K PE ++ +  E+  T   E            
Sbjct: 542 SIKMEAEPAEPLAAAVEAANGAEQTRVNKAPEGRSPLSAEELMTIEDEGV---------- 591

Query: 208 KEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSP 267
            +K  D+    E +K +     +   ++ D +++ +    +EA  +       E    + 
Sbjct: 592 LDKMLDQSTDFEERKLIRAALRELRQRKRDQRDKERERRLQEARGRPG-----EGRGNTA 646

Query: 268 SEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLST-----------DGLGPDCVAS 316
           +E   +  ++  +G A    +  E    S  G     +T           +G G   + +
Sbjct: 647 TETTTRHSQRAADGSAVSTVTKTERLVHSNDGTRTARTTTVESSFVRRSENGSGSTMMQT 706

Query: 317 GQTSPSASESSPSDV----PQSPPESPSSGEKKEKAPERR---VSAPARPRGPRAQNRKA 369
              S S+S      +     Q+ P + S    +++  E++   + A + P+   +Q RKA
Sbjct: 707 KTFSSSSSSKKMGSIFDREDQASPRAGSLAALEKRQAEKKKELMKAQSLPKTSASQARKA 766

Query: 370 IVDKF-----GGAASGPTALFRNTKAAGAA-IGGVKNMLLEWCRAMTKKYEHVDIQNFSS 423
           +++K       G+  GP A  + + + G      +K MLL+WCRA T+ YEHVDIQNFSS
Sbjct: 767 MIEKLEKEGAAGSPGGPRAAVQRSTSFGVPNANSIKQMLLDWCRAKTRGYEHVDIQNFSS 826

Query: 424 SWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRL- 482
           SWS GMAFCAL+H FFP+AFDY +L P  RR NF +AFS+AE  ADC QLLD +DMVRL 
Sbjct: 827 SWSDGMAFCALVHNFFPEAFDYGQLSPQNRRQNFEVAFSSAETHADCPQLLDTEDMVRLR 886

Query: 483 -----------------------AVPDSKCVYTYIQELYRSL 501
                                    PD KCV+TY+Q LY  L
Sbjct: 887 EPDWKMLVDCVPLVEVDDMMIMGKKPDPKCVFTYVQSLYNHL 928



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 62/267 (23%), Positives = 104/267 (38%), Gaps = 32/267 (11%)

Query: 111 ELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPE-SGQK 169
           EL++++ E+EE  + S+     +++ K         E+ L S++++AE++ A    +GQ 
Sbjct: 36  ELQRQELEREEEALASKRFRAERQDNK---------ENWLHSQQREAEQRAALARLAGQL 86

Query: 170 ADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEA 229
              ND         VEE  A   S  E  +RK      +     E   A     +     
Sbjct: 87  ESMND---------VEELTALLRSAGEYEERKLIRAAIRRVRAQEIEAATLAGRLYSGRP 137

Query: 230 KAEPKEPDGKEEAKHGAK--EEADAKEEAEDAEEAEPGSPSEEQEQDVE------KEPEG 281
            +  +E D K  A H  +  E  + +E+ + AE ++P    E   QDV       + P G
Sbjct: 138 NSGSRE-DSKGLAAHRLEQCEVPEREEQEQQAEVSKPTPTPEGTSQDVTTVTLLLRAPPG 196

Query: 282 GAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCV-ASGQTSPSASESSPSDVPQSPPESPS 340
                P+SP     SPT        +     C+ A    SP    S P      P ESP+
Sbjct: 197 STSSSPASPSS---SPTPASPEPPLEPAEAQCLTAEVPGSPEPPPSPPKTTSPEPQESPT 253

Query: 341 SGEKKEKAPERRVSAPARPRGPRAQNR 367
               + +   + +S P      ++ +R
Sbjct: 254 LPSTEGQVVNKLLSGPKETPAAQSPHR 280


>gi|169234649 smoothelin-like 2 isoform 2 [Homo sapiens]
          Length = 317

 Score =  164 bits (414), Expect = 2e-40
 Identities = 97/237 (40%), Positives = 135/237 (56%), Gaps = 24/237 (10%)

Query: 284 GVIPSSPE---EWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPS 340
           G+ PS  E    W  SP+ +  + +         +SG  + +AS+ S S    +PP+SP 
Sbjct: 82  GLNPSPSEVITPWTPSPSEKNSSFTWS-----VPSSGYGAVTASKHSNSPPLVTPPQSPV 136

Query: 341 SGE-----KKEKAPERR---VSAPARPRGPRAQNRKAIVDKFG-------GAASGPTALF 385
           S +     +  +  ERR   V +   PR   AQ RKA+ +K+        G       L 
Sbjct: 137 SPQPPAITQVHRQGERRRELVRSQTLPRTSEAQARKALFEKWEQETAAGKGKGEARARLK 196

Query: 386 RNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDY 445
           R+     A+   +K +LLEWCR+ T  Y+HVD+QNFSSSWS GMAFCAL+H FFPDAFDY
Sbjct: 197 RSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDY 256

Query: 446 AELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLA-VPDSKCVYTYIQELYRSL 501
             L P +R+ NF LAF+ AE LA+C +L++V+DM+ +   PD  CV+TY+Q LY  L
Sbjct: 257 NSLSPTQRQKNFELAFTMAENLANCERLIEVEDMMVMGRKPDPMCVFTYVQSLYNHL 313


>gi|169234647 smoothelin-like 2 isoform 1 [Homo sapiens]
          Length = 461

 Score =  164 bits (414), Expect = 2e-40
 Identities = 97/237 (40%), Positives = 135/237 (56%), Gaps = 24/237 (10%)

Query: 284 GVIPSSPE---EWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPS 340
           G+ PS  E    W  SP+ +  + +         +SG  + +AS+ S S    +PP+SP 
Sbjct: 226 GLNPSPSEVITPWTPSPSEKNSSFTWS-----VPSSGYGAVTASKHSNSPPLVTPPQSPV 280

Query: 341 SGE-----KKEKAPERR---VSAPARPRGPRAQNRKAIVDKFG-------GAASGPTALF 385
           S +     +  +  ERR   V +   PR   AQ RKA+ +K+        G       L 
Sbjct: 281 SPQPPAITQVHRQGERRRELVRSQTLPRTSEAQARKALFEKWEQETAAGKGKGEARARLK 340

Query: 386 RNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDY 445
           R+     A+   +K +LLEWCR+ T  Y+HVD+QNFSSSWS GMAFCAL+H FFPDAFDY
Sbjct: 341 RSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDY 400

Query: 446 AELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLA-VPDSKCVYTYIQELYRSL 501
             L P +R+ NF LAF+ AE LA+C +L++V+DM+ +   PD  CV+TY+Q LY  L
Sbjct: 401 NSLSPTQRQKNFELAFTMAENLANCERLIEVEDMMVMGRKPDPMCVFTYVQSLYNHL 457


>gi|150378549 tangerin [Homo sapiens]
          Length = 1523

 Score =  108 bits (271), Expect = 9e-24
 Identities = 125/440 (28%), Positives = 183/440 (41%), Gaps = 88/440 (20%)

Query: 69   GKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQE 128
            G QE A  + G+   L+ +  G+        +E GG E  E       G  E   +G+QE
Sbjct: 775  GTQEIASRDSGVPG-LEADTTGIQV------KEVGGSEVPEIAT----GTAETEILGTQE 823

Query: 129  MTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATV---E 185
            +  R     S      E E   A E +      + PE+G  A+A      + +  V   E
Sbjct: 824  IASR-----SSGVPGLESEVAGAQETEVGGSGISGPEAGM-AEARVLMTRKTEIIVPEAE 877

Query: 186  EEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKE----- 240
            +E+A+T+  +E   R   +     K     A     + +   EAKAE     G E     
Sbjct: 878  KEEAQTSGVQEAETRVGSAL----KYEALRAPVTQPRVLGSQEAKAEISGVQGSETQVLR 933

Query: 241  --EAKHGAKEEADAKEEAEDAEEAEPGS-PSEEQEQDVEKEPEGGAGVIPSSPEEWPESP 297
              EA+ G    ++ K  A  A+EAE     S E +    K  E  AGV+ +   +  E  
Sbjct: 934  VQEAEAGVWGMSEGKSGAWGAQEAEMKVLESPENKSGTFKAQEAEAGVLGNEKGKEAEG- 992

Query: 298  TGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPA 357
                 +L+   L    VASG  + +   SSP                 EKA E R     
Sbjct: 993  -----SLTEASLPEAQVASGAGAGAPRASSP-----------------EKAEEDR----- 1025

Query: 358  RPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVD 417
              R P +Q               P AL  ++++           LLEWC+ +T  Y  V 
Sbjct: 1026 --RLPGSQ--------------APPALVSSSQS-----------LLEWCQEVTTGYRGVR 1058

Query: 418  IQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVD 477
            I NF++SW +G+AFCA++H+F+PD  DYA LDP   + N   AF     L   ++LL+  
Sbjct: 1059 ITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQAFDGFAALG-VSRLLEPA 1117

Query: 478  DMVRLAVPDSKCVYTYIQEL 497
            DMV L+VPD   V TY+ ++
Sbjct: 1118 DMVLLSVPDKLIVMTYLCQI 1137



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 70/319 (21%), Positives = 110/319 (34%), Gaps = 39/319 (12%)

Query: 15  AREKMEQKEGKLSEDGTTVSPAAD-----NPEMSGGGAPAEETKGTAGKAINEG-----P 64
           AR    Q   + +E G  V P A      +PEM     PA++T  T    + +G     P
Sbjct: 256 ARTSRGQGSERANEAGGQVGPEAPRPPETSPEMRSSRQPAQDTAPTPAPRLRKGSDALRP 315

Query: 65  PTESGKQE------KAPAEDGMSAELQGEANGLDEVKVESQREAGGKED-------AEAE 111
           P   G+ E        PA  G + E Q +A   +  +    R     ED           
Sbjct: 316 PVPQGEDEVPKASGAPPAGLGSARETQAQACPQEGTEAHGARLGPSIEDKGSGDPFGRQR 375

Query: 112 LKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKAD 171
           LK E+ + E+      E +G   E +S  +EA  K S + + + +      + ++ Q++ 
Sbjct: 376 LKAEEMDTEDRP----EASGVDTEPRSGGREANTKRSGVRAGEAEESSAVCQVDAEQRSK 431

Query: 172 ANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKA 231
               D   P+AT    +A+     E   R         +  DE     S          A
Sbjct: 432 VRHVDTKGPEATGVMPEARCRGTPEAPPRGS-QGRLGVRTRDEAPSGLSL-------PPA 483

Query: 232 EPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPE 291
           EP    G+     GA+  A  + E  +     PG     +   +E+ P  GA        
Sbjct: 484 EPAGHSGQLGDLEGARAAAGQEREGAEVRGGAPGI----EGTGLEQGPSVGAISTRPQVS 539

Query: 292 EWPESPTGEGHNLSTDGLG 310
            W  +         + GLG
Sbjct: 540 SWQGALLSTAQGAISRGLG 558



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 40/163 (24%), Positives = 58/163 (35%), Gaps = 22/163 (13%)

Query: 228 EAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIP 287
           EA+A   +PD   E K   +EE    EE +   +    SPS    +D    P       P
Sbjct: 203 EARARVPQPDPSRELKTLCEEE----EEGQGRPQQAVASPS--NAEDTSPAPVSA----P 252

Query: 288 SSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEK 347
           + P         E  N +   +GP+     +TSP    S       +P  +P        
Sbjct: 253 APPARTSRGQGSERANEAGGQVGPEAPRPPETSPEMRSSRQPAQDTAPTPAPRL------ 306

Query: 348 APERRVSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKA 390
              R+ S   RP  P+ ++    V K  GA        R T+A
Sbjct: 307 ---RKGSDALRPPVPQGEDE---VPKASGAPPAGLGSARETQA 343


>gi|224451082 cytospin A [Homo sapiens]
          Length = 1117

 Score =  107 bits (266), Expect = 3e-23
 Identities = 109/444 (24%), Positives = 174/444 (39%), Gaps = 68/444 (15%)

Query: 82   AELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKEETKSEPK 141
            ++L+     L + K + +RE    +     L++E  E  +     Q       + KSE +
Sbjct: 712  SDLENTVKKLQDQKHDMEREI---KTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQ 768

Query: 142  E-----------AEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAK 190
            E           A+EK   L  E ++ + ++ + E G+  +  +         VE + A 
Sbjct: 769  EEIGDLKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMN--------AVERDLAA 820

Query: 191  TASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEA 250
                    +R   S+EP           +S   V    A A P+ P      K      A
Sbjct: 821  LRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPRTPLSPSPMK---TPPA 877

Query: 251  DAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIP---------SSPEEWPESPTGEG 301
             A    +    + P S S+      +K P  G   +          S P   P  P  E 
Sbjct: 878  AAVSPMQRHSISGPISTSKPLTALSDKRPNYGEIPVQEHLLRTSSASRPASLPRVPAMES 937

Query: 302  HNL------STDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSA 355
                     S++ +  D  A    SP++  +  +  PQ    S SS       P  R   
Sbjct: 938  AKTLSVSRRSSEEVKRDISAQEGASPASLMAMGTTSPQL---SLSSSPTASVTPTTR--- 991

Query: 356  PARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEH 415
             +R R  R     A+  ++GG+                     +N LL+WC+  T+ Y++
Sbjct: 992  -SRIREERKDPLSALAREYGGSK--------------------RNALLKWCQKKTEGYQN 1030

Query: 416  VDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLD 475
            +DI NFSSSW+ G+AFCAL+H + P    Y EL+   +R NF LAF  AE +      LD
Sbjct: 1031 IDITNFSSSWNDGLAFCALLHTYLPAHIPYQELNSQDKRRNFMLAFQAAESVG-IKSTLD 1089

Query: 476  VDDMVRLAVPDSKCVYTYIQELYR 499
            +++MVR   PD + V  Y+  +Y+
Sbjct: 1090 INEMVRTERPDWQNVMLYVTAIYK 1113



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 43/193 (22%), Positives = 77/193 (39%), Gaps = 18/193 (9%)

Query: 79  GMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKE-DGEKEETTVGSQEMTGRKEETK 137
           G+   L       ++   E+Q   G  ++    +++  + E++     +  +   K    
Sbjct: 511 GVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVA 570

Query: 138 SEPKEAEEKESTLASEKQKAEEKEAKPESGQKADAN--------DRDKPEPKATVEEED- 188
           S+  E    ++ L +EKQK  E  +   SG K+D          D++K E  A+  +ED 
Sbjct: 571 SDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDL 630

Query: 189 AKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKE 248
           A T +     Q      E + +A  EEAK +     +ED      K     +E +    E
Sbjct: 631 AHTRNDANRLQDAIAKVEDEYRAFQEEAKKQ-----IEDLNMTLEKLRSDLDEKE---TE 682

Query: 249 EADAKEEAEDAEE 261
            +D KE   + E+
Sbjct: 683 RSDMKETIFELED 695


>gi|224451080 cytospin A [Homo sapiens]
          Length = 1117

 Score =  107 bits (266), Expect = 3e-23
 Identities = 109/444 (24%), Positives = 174/444 (39%), Gaps = 68/444 (15%)

Query: 82   AELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKEETKSEPK 141
            ++L+     L + K + +RE    +     L++E  E  +     Q       + KSE +
Sbjct: 712  SDLENTVKKLQDQKHDMEREI---KTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQ 768

Query: 142  E-----------AEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAK 190
            E           A+EK   L  E ++ + ++ + E G+  +  +         VE + A 
Sbjct: 769  EEIGDLKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMN--------AVERDLAA 820

Query: 191  TASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEA 250
                    +R   S+EP           +S   V    A A P+ P      K      A
Sbjct: 821  LRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPRTPLSPSPMK---TPPA 877

Query: 251  DAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIP---------SSPEEWPESPTGEG 301
             A    +    + P S S+      +K P  G   +          S P   P  P  E 
Sbjct: 878  AAVSPMQRHSISGPISTSKPLTALSDKRPNYGEIPVQEHLLRTSSASRPASLPRVPAMES 937

Query: 302  HNL------STDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSA 355
                     S++ +  D  A    SP++  +  +  PQ    S SS       P  R   
Sbjct: 938  AKTLSVSRRSSEEVKRDISAQEGASPASLMAMGTTSPQL---SLSSSPTASVTPTTR--- 991

Query: 356  PARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEH 415
             +R R  R     A+  ++GG+                     +N LL+WC+  T+ Y++
Sbjct: 992  -SRIREERKDPLSALAREYGGSK--------------------RNALLKWCQKKTEGYQN 1030

Query: 416  VDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLD 475
            +DI NFSSSW+ G+AFCAL+H + P    Y EL+   +R NF LAF  AE +      LD
Sbjct: 1031 IDITNFSSSWNDGLAFCALLHTYLPAHIPYQELNSQDKRRNFMLAFQAAESVG-IKSTLD 1089

Query: 476  VDDMVRLAVPDSKCVYTYIQELYR 499
            +++MVR   PD + V  Y+  +Y+
Sbjct: 1090 INEMVRTERPDWQNVMLYVTAIYK 1113



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 43/193 (22%), Positives = 77/193 (39%), Gaps = 18/193 (9%)

Query: 79  GMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKE-DGEKEETTVGSQEMTGRKEETK 137
           G+   L       ++   E+Q   G  ++    +++  + E++     +  +   K    
Sbjct: 511 GVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVA 570

Query: 138 SEPKEAEEKESTLASEKQKAEEKEAKPESGQKADAN--------DRDKPEPKATVEEED- 188
           S+  E    ++ L +EKQK  E  +   SG K+D          D++K E  A+  +ED 
Sbjct: 571 SDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDL 630

Query: 189 AKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKE 248
           A T +     Q      E + +A  EEAK +     +ED      K     +E +    E
Sbjct: 631 AHTRNDANRLQDAIAKVEDEYRAFQEEAKKQ-----IEDLNMTLEKLRSDLDEKE---TE 682

Query: 249 EADAKEEAEDAEE 261
            +D KE   + E+
Sbjct: 683 RSDMKETIFELED 695


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 98/329 (29%), Positives = 151/329 (45%), Gaps = 33/329 (10%)

Query: 7    GESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPT 66
            GE +     RE+ E+KEG+  E+G       +  E   G    EE  G   K   EG   
Sbjct: 736  GEGEEEEGDREEEEEKEGEGKEEGEGEEVEGER-EKEEGERKKEERAGKEEKGEEEGDQG 794

Query: 67   ESGKQEKAPAEDGMSAELQGEANG--LDEVKVE--SQREAGGKEDAEAELKKEDGE-KEE 121
            E G++E+     G   E  GE  G  ++E K E   + E G  E+ E E ++E+GE +EE
Sbjct: 795  E-GEEEETEGR-GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEE 852

Query: 122  TTVGSQEMTGRKEETKSEPKE----AEEKESTLASEKQ---KAEEKEAKPESGQKADA-N 173
               G  E  G + E + E +E     EE+E     E++   + EE+E + E  ++ +   
Sbjct: 853  EGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEG 912

Query: 174  DRDKPEPKATVEEEDAKTASQEETGQRK----ECSTEPKE---KATDEEAKAESQKAVVE 226
            + ++ E K   E E+ +   +EE G+ +    E   E +E   +  +EE + E ++   E
Sbjct: 913  EEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEE---E 969

Query: 227  DEAKAEPKEPDGKEEAKHGAKEEADAKEEAE---DAEEAEPGSPSEEQEQDVEKEPEGGA 283
             E + E  E +G+EE   G  EE + +EE E   + EE   G   EE+E +VE E EG  
Sbjct: 970  GEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEE 1029

Query: 284  GVIPSSPEEWPESPTGEGHNLSTDGLGPD 312
            G      EE  E    EG     +G G +
Sbjct: 1030 GEGEGEEEEGEE----EGEEREKEGEGEE 1054



 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 101/398 (25%), Positives = 155/398 (38%), Gaps = 68/398 (17%)

Query: 12   SAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGA------------PAEETKGTAGKA 59
            S +  +K E  EGK      +V  A D PE  G G               E  KG   K 
Sbjct: 627  SDDLTDKAEVSEGKAK----SVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKG 682

Query: 60   INEGPPTESGKQEKAPAE-----DGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKK 114
              E      G++E A  E     DG   E +    G  + + +   E G +E  E E ++
Sbjct: 683  RGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEE 742

Query: 115  EDGEKEETTVGSQEMTGRKEETKSE--PKEAEEKESTLASEKQKAEEK------------ 160
             D E+EE   G  +  G  EE + E   +E E K+   A +++K EE+            
Sbjct: 743  GDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETE 802

Query: 161  ---EAKPESGQ------KADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKA 211
               E K E G+      +    +R++ E +   EEE+ +   +EE G+ +E   E K + 
Sbjct: 803  GRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGE--GEEEEGEGEEEEGEGKGEE 860

Query: 212  TDEEAKAESQKAVVEDEAKAEPKEPDGKEEAK-HGAKEEADAKEEAE---DAEEAEPGSP 267
              EE + E +    E E + E  E +G+EE +  G +EE + + E E   + EE E    
Sbjct: 861  EGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGK 920

Query: 268  SEE---------QEQDVEKEPEGGAGVIPSSPEEW---------PESPTGEGHNLSTDGL 309
             EE         +E++ E E E G G       EW              GEG     +G 
Sbjct: 921  GEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGE 980

Query: 310  GPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEK 347
            G +    G+      E    +  +   E    GE++E+
Sbjct: 981  GEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEE 1018



 Score = 92.4 bits (228), Expect = 9e-19
 Identities = 104/392 (26%), Positives = 165/392 (42%), Gaps = 56/392 (14%)

Query: 5   AVGESDCSAEAREKMEQKEGK-----------LSEDGTTVSPAADN----PEMSGGGAPA 49
           A+ E+D S E  E  E KEGK           +++  TT+   +D     PE   G   A
Sbjct: 537 ALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEG---A 593

Query: 50  EETKGTA-----GKAINEGPPTESGKQEK-----------APAEDGMSAELQGEANGLDE 93
           E++KG        +A  E      G++EK           A   +G  A+  GEA    E
Sbjct: 594 EDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEG-KAKSVGEAEDGPE 652

Query: 94  VKVESQREAGGK-----EDAEAELKKED---GEKEETTVGSQEMTGRKEETKSEPKEAEE 145
            + +   E G       +D E E  ++D   GE E    G +E+  ++E  K + +E E+
Sbjct: 653 GRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQ 712

Query: 146 KESTLASEKQKAEEKE--AKPESGQ-KADANDRDKPEPKATVEEEDAKTASQEETGQR-K 201
           KE     +K++ +E E   + E G+ + +  DR++ E K    +E+ +   +E  G+R K
Sbjct: 713 KEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGE--GEEVEGEREK 770

Query: 202 ECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGK-EEAKHGAKEEADAKEE--AED 258
           E     KE+   +E K E +     D+ + E +E +G+ EE + G + E    EE   E 
Sbjct: 771 EEGERKKEERAGKEEKGEEE----GDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGER 826

Query: 259 AEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQ 318
            EE E G   EE+ +  E+E EG         EE  E   GE      +G G +    G+
Sbjct: 827 EEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGE 886

Query: 319 TSPSASESSPSDVPQSPPESPSSGEKKEKAPE 350
                      +  +   E    GE +E+  E
Sbjct: 887 GEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGE 918



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 80/273 (29%), Positives = 127/273 (46%), Gaps = 25/273 (9%)

Query: 14   EAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTES-GKQE 72
            E  E+ E+ EG+  E+G       +  E  G G   EE  G  G+   EG   E  G++E
Sbjct: 825  EREEEEEEGEGE-EEEGEGEEEEGEGEEEEGEGKGEEE--GEEGEGEEEGEEGEGEGEEE 881

Query: 73   KAPAE-----DGMSAELQGEANGLDEVKVESQREAG-GKEDAEAELKKEDGEKEETTVGS 126
            +   E     +G   E +GE  G +E + E + E G GK + E E  + +GE+EE     
Sbjct: 882  EGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEG 941

Query: 127  QEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEE 186
            ++  G  EE + E  E EE+E     E +  EE E + E G+     + ++ E +   EE
Sbjct: 942  EDGEGEGEEEEGE-WEGEEEEG----EGEGEEEGEGEGEEGE----GEGEEEEGEGEGEE 992

Query: 187  EDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGA 246
            E+      EE G+ +    E  E   +EE + E +  V  +E + E +E +G+EE +   
Sbjct: 993  EEG-----EEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEERE 1047

Query: 247  KE-EADAKEEAEDAEEAEPGSPSEEQEQDVEKE 278
            KE E +      + EE E G   E  E++ E++
Sbjct: 1048 KEGEGEENRRNREEEEEEEGKYQETGEEENERQ 1080



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 86/309 (27%), Positives = 139/309 (44%), Gaps = 26/309 (8%)

Query: 4    GAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEG 63
            G   E++   E +E+  + EG   E+G       +  E  G G   EE +G   +   EG
Sbjct: 796  GEEEETEGRGEEKEEGGEVEGGEVEEG---KGEREEEEEEGEG---EEEEGEGEEEEGEG 849

Query: 64   PPTESGKQEKAPAEDGMSAEL--QGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEE 121
               E   + +   E+G   E   +GE  G +E     + E  G+E+ E E ++E+GE E 
Sbjct: 850  EEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEE-----EGEGEGEEEGEGEGEEEEGEGE- 903

Query: 122  TTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPK 181
               G +E  G  EE + E K  EE E      + + EE E + E G+     + ++ E +
Sbjct: 904  ---GEEEGEGEGEEEEGEGKGEEEGEE--GEGEGEEEEGEGEGEDGE----GEGEEEEGE 954

Query: 182  ATVEEEDAKTASQEE-TGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPK-EPDGK 239
               EEE+ +   +EE  G+ +E   E +E+  + E + E  +   E+E + E + E +G+
Sbjct: 955  WEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGE 1014

Query: 240  EEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTG 299
            EE +   + E + +E   + EE E     EE+E++ E E E          EE     TG
Sbjct: 1015 EEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGE-ENRRNREEEEEEEGKYQETG 1073

Query: 300  EGHNLSTDG 308
            E  N   DG
Sbjct: 1074 EEENERQDG 1082



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 69/267 (25%), Positives = 112/267 (41%), Gaps = 28/267 (10%)

Query: 7    GESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPT 66
            GE +   E + + E +EG+  E+G       +  E  G G   EE +G   +   EG   
Sbjct: 849  GEEE-EGEGKGEEEGEEGEGEEEGE--EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGE 905

Query: 67   ESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGS 126
            E G+ E    E     E +GE     E + E +   G  ED E E ++E+GE E      
Sbjct: 906  EEGEGEGEEEEGEGKGEEEGEEG---EGEGEEEEGEGEGEDGEGEGEEEEGEWE------ 956

Query: 127  QEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEE 186
                G +EE + E +E  E E      + + EE E     G+  +    ++ E +   EE
Sbjct: 957  ----GEEEEGEGEGEEEGEGEGEEGEGEGEEEEGE-----GEGEEEEGEEEGEEEGEGEE 1007

Query: 187  EDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGA 246
            E      +EE G       E + +   EE + E ++   E+E +   KE +G+E  ++  
Sbjct: 1008 EGEGEGEEEEEG-------EVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNRE 1060

Query: 247  KEEADAKEEAEDAEEAEPGSPSEEQEQ 273
            +EE +  +  E  EE       EE ++
Sbjct: 1061 EEEEEEGKYQETGEEENERQDGEEYKK 1087



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 59/221 (26%), Positives = 96/221 (43%), Gaps = 21/221 (9%)

Query: 7    GESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETK-----GTAGKAIN 61
            GE +   E   + E+ EG+  E+G       +  E  G G   EE +     G   +   
Sbjct: 885  GEGEEEGEGEGEEEEGEGEGEEEGE-----GEGEEEEGEGKGEEEGEEGEGEGEEEEGEG 939

Query: 62   EGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEE 121
            EG   E   +E+    +G   E +GE     E + E     G +E+ E E ++E+GE+E 
Sbjct: 940  EGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEE- 998

Query: 122  TTVGSQEMTGRKE-ETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEP 180
               G +E  G +E E + E +E  E E  +  E+ + E +E + E   +    + +  E 
Sbjct: 999  ---GEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEEN 1055

Query: 181  KATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQ 221
            +   EEE      +EE G+ +E   E  E+   EE K  S+
Sbjct: 1056 RRNREEE------EEEEGKYQETGEEENERQDGEEYKKVSK 1090


>gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo
           sapiens]
          Length = 987

 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 118/516 (22%), Positives = 209/516 (40%), Gaps = 100/516 (19%)

Query: 72  EKAPAEDGMSAELQGEANGLDEVKVESQREAGGKE----DAEAELKKEDGEKEETTVGSQ 127
           EK  A +  + E   E+  + E+   ++ E    E    +   EL K +GE +  +    
Sbjct: 480 EKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVS---- 535

Query: 128 EMTGRKEETKSEPKE-----AEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKA 182
            +  + E+  S  KE     AE+   T    ++KA E +A+ +  ++      D+ E   
Sbjct: 536 SLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHR 595

Query: 183 TVEEEDAKTASQEETG----QRKECSTEPKEKATDEEAKAESQK-----------AVVED 227
            V+  + +  S+ E+     + ++   E + K   ++ K E+++            VV +
Sbjct: 596 AVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVAN 655

Query: 228 EAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGS---------PSEEQEQDVEKE 278
           + K E ++     + K   +EE +A+ + E  +    G          P +E+ +  E +
Sbjct: 656 DIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPPVDEEPESSEVD 715

Query: 279 PEG---GAGVIPSSPEEWPES---------------PTGEGHNLSTDGLGPDCVASG--- 317
             G   G  V  +SP   PES               P G G N+S     P    SG   
Sbjct: 716 AAGRWPGVCVSRTSPTP-PESATTVKSLIKSFDLGRPGGAGQNISVHKT-PRSPLSGIPV 773

Query: 318 QTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVD----- 372
           +T+P+A+ S     P     + SS     +   +R+  P  P     + R   +      
Sbjct: 774 RTAPAAAVS-----PMQRHSTYSSVRPASRGVTQRLDLPDLPLSDILKGRTETLKPDPHL 828

Query: 373 ----KFGGAASGPTALFRNTKAAGAAI-------------------------GGVKNMLL 403
                    +  P+  F +T+   A+                          G  +N LL
Sbjct: 829 RKSPSLESLSRPPSLGFGDTRLLSASTRAWKPQSKLSVERKDPLAALAREYGGSKRNALL 888

Query: 404 EWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFST 463
           +WC+  T+ Y ++DI NFSSSWS G+AFCAL+H + P    Y EL+  +++ N  LAF  
Sbjct: 889 KWCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEA 948

Query: 464 AEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYR 499
           AE +      L++ +M+    PD + V  Y+ ++Y+
Sbjct: 949 AESVG-IKPSLELSEMLYTDRPDWQSVMQYVAQIYK 983


>gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo
            sapiens]
          Length = 1068

 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 118/516 (22%), Positives = 209/516 (40%), Gaps = 100/516 (19%)

Query: 72   EKAPAEDGMSAELQGEANGLDEVKVESQREAGGKE----DAEAELKKEDGEKEETTVGSQ 127
            EK  A +  + E   E+  + E+   ++ E    E    +   EL K +GE +  +    
Sbjct: 561  EKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVS---- 616

Query: 128  EMTGRKEETKSEPKE-----AEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKA 182
             +  + E+  S  KE     AE+   T    ++KA E +A+ +  ++      D+ E   
Sbjct: 617  SLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHR 676

Query: 183  TVEEEDAKTASQEETG----QRKECSTEPKEKATDEEAKAESQK-----------AVVED 227
             V+  + +  S+ E+     + ++   E + K   ++ K E+++            VV +
Sbjct: 677  AVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVAN 736

Query: 228  EAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGS---------PSEEQEQDVEKE 278
            + K E ++     + K   +EE +A+ + E  +    G          P +E+ +  E +
Sbjct: 737  DIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPPVDEEPESSEVD 796

Query: 279  PEG---GAGVIPSSPEEWPES---------------PTGEGHNLSTDGLGPDCVASG--- 317
              G   G  V  +SP   PES               P G G N+S     P    SG   
Sbjct: 797  AAGRWPGVCVSRTSPTP-PESATTVKSLIKSFDLGRPGGAGQNISVHKT-PRSPLSGIPV 854

Query: 318  QTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVD----- 372
            +T+P+A+ S     P     + SS     +   +R+  P  P     + R   +      
Sbjct: 855  RTAPAAAVS-----PMQRHSTYSSVRPASRGVTQRLDLPDLPLSDILKGRTETLKPDPHL 909

Query: 373  ----KFGGAASGPTALFRNTKAAGAAI-------------------------GGVKNMLL 403
                     +  P+  F +T+   A+                          G  +N LL
Sbjct: 910  RKSPSLESLSRPPSLGFGDTRLLSASTRAWKPQSKLSVERKDPLAALAREYGGSKRNALL 969

Query: 404  EWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFST 463
            +WC+  T+ Y ++DI NFSSSWS G+AFCAL+H + P    Y EL+  +++ N  LAF  
Sbjct: 970  KWCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEA 1029

Query: 464  AEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYR 499
            AE +      L++ +M+    PD + V  Y+ ++Y+
Sbjct: 1030 AESVG-IKPSLELSEMLYTDRPDWQSVMQYVAQIYK 1064


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 96/346 (27%), Positives = 156/346 (45%), Gaps = 41/346 (11%)

Query: 72  EKAPAEDGMSAELQGEANGLDEVKVESQREA----GGKEDAEAELKKEDGEKEETTVGSQ 127
           EK+  E  +  E   E    +EV  E ++EA    G +E+   E + E GE+E  +  ++
Sbjct: 448 EKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAE 507

Query: 128 EMTGRKEETKSEPKE---------AEEKESTLASEKQKAEEK---EAKPESGQKADANDR 175
           E    ++E KS  KE         + EKE   +  + K+ EK    AK E+    +A   
Sbjct: 508 EAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSP 567

Query: 176 DKPEPKATVE---EEDAKTASQEETGQRKECSTEPKEKA-TDEEAKAESQ-KAVVEDEAK 230
           +K E K+  E    E AK+ ++EE     E  +  K K+   EEAK+ ++ K+ V++EAK
Sbjct: 568 EKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK 627

Query: 231 --AEPKEPD-----GKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGA 283
             AE K P+      KEEAK   K ++  KEEA+  E+A+    +E +  +  K P    
Sbjct: 628 SPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAE 687

Query: 284 GVIP----SSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESP 339
              P    S  +E  +SP      +  +   P+       SP   E+   +  +SP +  
Sbjct: 688 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE----KAKSPVKEEAKTPEKAKSPVKEE 743

Query: 340 SSGEKKEKAPERR----VSAPARPRGPRAQNRKAIVDKFGGAASGP 381
           +   +K K+PE+     V +P   + P  +  ++  DKF   A  P
Sbjct: 744 AKSPEKAKSPEKAKTLDVKSP-EAKTPAKEEARSPADKFPEKAKSP 788



 Score = 92.4 bits (228), Expect = 9e-19
 Identities = 98/360 (27%), Positives = 154/360 (42%), Gaps = 31/360 (8%)

Query: 20  EQKEGKLSEDGTTVSPA--ADNPEMSGGGAPAEETKGTAGKAINEGP----PTESGKQEK 73
           E++E +  E+ T   PA  A +PE        EE K  A     E      P E    EK
Sbjct: 490 EEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEK 549

Query: 74  APAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRK 133
           A +     A+   EA   ++ + +S  E    E A++  K+E     E     +  +  K
Sbjct: 550 AKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVK 609

Query: 134 EETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKTAS 193
           EE KS    AE K       K  AE K   PE  +     +   PE   + E+E+AK+  
Sbjct: 610 EEAKSP---AEAKSPVKEEAKSPAEVKS--PEKAKSPTKEEAKSPEKAKSPEKEEAKSPE 664

Query: 194 QEETGQRKECSTEPKEKA-TDEEAKA-ESQKAVVEDEAKAEPKEPDG-KEEAKHGAKEEA 250
           + ++  + E  +  K K+    EAK+ E  K+ V++EAK+  K     KEEAK   K ++
Sbjct: 665 KAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKS 724

Query: 251 DAKEEAEDAEEAEPGSPSEEQEQDVE--KEPEGGAGVIPSSPEEWPESPTGEGHNLSTDG 308
             KEEA+  E+A+  SP +E+ +  E  K PE    +   SPE   ++P  E      D 
Sbjct: 725 PVKEEAKTPEKAK--SPVKEEAKSPEKAKSPEKAKTLDVKSPE--AKTPAKEEARSPADK 780

Query: 309 LGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRK 368
                       P  ++S   +  +SP ++ S  ++  KAPE+ +      + P  +  K
Sbjct: 781 F-----------PEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829



 Score = 90.5 bits (223), Expect = 3e-18
 Identities = 101/385 (26%), Positives = 165/385 (42%), Gaps = 40/385 (10%)

Query: 8   ESDCSAEAREKMEQKEGKLSEDGTTVSPA-ADNPEMSGGGAPAE-----ETKGTAGKAIN 61
           E+   AEA+   E+ +  + E+    SPA A +P      +PAE     + K    +   
Sbjct: 591 EAKSPAEAKSP-EKAKSPVKEEAK--SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAK 647

Query: 62  EGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEE 121
                +S ++E+A + +   + ++ EA   ++ K   + EA   E A++ +K+E    E+
Sbjct: 648 SPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEK 707

Query: 122 TTVGSQEMTGRKEETKSEPKE---AEEKESTLASEKQKAEEKEAKPESGQKADANDRDKP 178
                +E     E+ KS  KE     EK  +   E+ K+ EK   PE   KA   D   P
Sbjct: 708 AKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPE---KAKTLDVKSP 764

Query: 179 EPKATVEEE----------DAKTASQEETGQRKECSTEPKE--KATDEEA-KAESQKAVV 225
           E K   +EE           AK+  +EE    ++  +  KE  KA ++E  K E  K+ V
Sbjct: 765 EAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPV 824

Query: 226 EDEAKAEP---KEPDGKEEAKHG-----AKEEADAKEEAEDAEEAEPGSPSEEQEQDVEK 277
           ++E K +    KEP  K E +        +E+ D+K+E    +EA      E++E  VEK
Sbjct: 825 KEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEK 884

Query: 278 EPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPE 337
             E          E+  + PT E    +   +  D     +T  +  E  P D     P 
Sbjct: 885 PKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKE--PDDAKAKEPS 942

Query: 338 SPSSGEKKEKAPERRVSAPARPRGP 362
            P+  EKKE APE++ +   + + P
Sbjct: 943 KPA--EKKEAAPEKKDTKEEKAKKP 965



 Score = 89.7 bits (221), Expect = 6e-18
 Identities = 85/370 (22%), Positives = 163/370 (44%), Gaps = 32/370 (8%)

Query: 14  EAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEK 73
           E + +  Q   +++E+    +   +  E  GG    EE +   G+   + PP E    E 
Sbjct: 458 EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGG----EEEEAEGGEEETKSPPAE----EA 509

Query: 74  APAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRK 133
           A  E    + ++ EA    E K   + EA    + ++  K +   KEE     +  +  K
Sbjct: 510 ASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK 569

Query: 134 EETKSEPK-EAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKTA 192
           EE KS  + ++ EK  + A E+ K+  +   PE  +     +   P    +  +E+AK+ 
Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSP 629

Query: 193 SQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEA----KAEPKEPDG-----KEEAK 243
           ++ ++ ++ +  T+ + K+ ++    E ++A   ++A    KAE K P+      K EAK
Sbjct: 630 AEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAK 689

Query: 244 HGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHN 303
              K ++  KEEA+  E+A+  SP +E+ +  EK          S  +E  ++P      
Sbjct: 690 SPEKAKSPVKEEAKSPEKAK--SPVKEEAKSPEK--------AKSPVKEEAKTPEKAKSP 739

Query: 304 LSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEK---KEKAP-ERRVSAPARP 359
           +  +   P+   S + + +    SP     +  E+ S  +K   K K+P +  V +P + 
Sbjct: 740 VKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKA 799

Query: 360 RGPRAQNRKA 369
           + P  ++ KA
Sbjct: 800 KSPLKEDAKA 809



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 103/392 (26%), Positives = 171/392 (43%), Gaps = 52/392 (13%)

Query: 8   ESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTE 67
           + +  + A  K  +K    +++     P A +PE     +PAE                +
Sbjct: 535 KEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAE---------------VK 579

Query: 68  SGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQ 127
           S ++ K+PA++   A+   EA   ++ K   + EA    +A++ +K+E     E     +
Sbjct: 580 SPEKAKSPAKE--EAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEK 637

Query: 128 EMTGRKEETKSEPK-EAEEKESTLASEKQKAEEK-EAK-PESGQ---KADANDRDK---P 178
             +  KEE KS  K ++ EKE   + EK K+  K EAK PE  +   KA+A   +K   P
Sbjct: 638 AKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSP 697

Query: 179 EPKATVEEEDAKTASQEETGQRKECSTEPKEKA-TDEEAKA-------ESQKAVVEDEAK 230
             +     E AK+  +EE    ++  +  KE+A T E+AK+         +KA   ++AK
Sbjct: 698 VKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAK 757

Query: 231 A-EPKEPDGKEEAKHGAKEEAD---------AKEEAEDAEEAEPGSPSEEQEQDVEKE-P 279
             + K P+ K  AK  A+  AD          KEE +  E+A+  SP +E  +  EKE P
Sbjct: 758 TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAK--SPLKEDAKAPEKEIP 815

Query: 280 EGGAGVIPSSPEEWP-ESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPES 338
           +      P   EE P E    E    + +   P   A+ +T     +S   + P+     
Sbjct: 816 KKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAP---ATPKTE-EKKDSKKEEAPKKEAPK 871

Query: 339 PSSGEKKEKAPERRVSAPARPRGPRAQNRKAI 370
           P   EKKE A E+   +    +   A+++K +
Sbjct: 872 PKVEEKKEPAVEKPKESKVEAKKEEAEDKKKV 903



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 93/372 (25%), Positives = 158/372 (42%), Gaps = 41/372 (11%)

Query: 12   SAEAREKMEQKEGKLSEDGTT-VSPAADNPEMSGGGAPAEETKGTAGKA-INEGPPTESG 69
            S E  +  E++E K  E   + V   A +PE +     AE       K+ + E    +S 
Sbjct: 648  SPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKE--EAKSP 705

Query: 70   KQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETT-VGSQE 128
            ++ K+P ++   +  + ++   +E K   + ++  KE+A++  K +  EK +T  V S E
Sbjct: 706  EKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPE 765

Query: 129  M-TGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEE 187
              T  KEE +S   +  EK  +   E+ K+ EK   P    K DA   +K  PK    +E
Sbjct: 766  AKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSP---LKEDAKAPEKEIPK----KE 818

Query: 188  DAKTASQEETGQRKECSTEPKEKATDEEA----KAESQKAVVEDEA------------KA 231
            + K+  +EE   ++    EP +KA +E+A    K E +K   ++EA            K 
Sbjct: 819  EVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKK 878

Query: 232  EPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPG-------SPSEEQEQDVEKEPEGGAG 284
            EP     KE      KEEA+ K++    E+  P        +  +E+ +  +KEP+    
Sbjct: 879  EPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKA 938

Query: 285  VIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSP-----PESP 339
              PS P E  E+   +          P+     +      + + S  P  P      +S 
Sbjct: 939  KEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSS 998

Query: 340  SSGEKKEKAPER 351
            S+ +K  K PE+
Sbjct: 999  STDQKDSKPPEK 1010



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 84/292 (28%), Positives = 138/292 (47%), Gaps = 25/292 (8%)

Query: 94  VKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASE 153
           +KV+S+ +    E +E E    + + EET V ++E+T   EE + E KE E KE     E
Sbjct: 436 IKVKSEEKIKVVEKSEKETVIVEEQTEETQV-TEEVT---EEEEKEAKEEEGKEEE-GGE 490

Query: 154 KQKAEEKEAKPESGQKADANDRDKPEPKATVEEE-----DAKTASQEETGQRKECSTEPK 208
           +++AE  E + +S    +A   +K E K+ V+EE     +AK+  +EE     E  +  K
Sbjct: 491 EEEAEGGEEETKSPPAEEAASPEK-EAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEK 549

Query: 209 EKA-TDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEA----- 262
            K+   EEAK+  +    E E    P E    E+AK  AKEEA +  EA+  E+A     
Sbjct: 550 AKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVK 609

Query: 263 EPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQ---- 318
           E      E +  V++E +  A V   SPE+  +SPT E          P+   +      
Sbjct: 610 EEAKSPAEAKSPVKEEAKSPAEV--KSPEK-AKSPTKEEAKSPEKAKSPEKEEAKSPEKA 666

Query: 319 TSPSASESSPSDVPQSPPESPSSGEKKEKAP-ERRVSAPARPRGPRAQNRKA 369
            SP  +E+   +  +SP ++ +   +K K+P +    +P + + P  +  K+
Sbjct: 667 KSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS 718



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 74/291 (25%), Positives = 131/291 (45%), Gaps = 30/291 (10%)

Query: 8    ESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINE----- 62
            +S    EA+   + K  + ++     SP A  P      +PA++    A   + E     
Sbjct: 737  KSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSP 796

Query: 63   ----GPPTESGK--QEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELK--- 113
                 P  E  K  +++ P ++ + + ++ E     EVKV+   +   +E A A  K   
Sbjct: 797  EKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKP-QEVKVKEPPKKAEEEKAPATPKTEE 855

Query: 114  KEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKP----ESGQK 169
            K+D +KEE     +E    K E K EP   + KES + ++K++AE+K+  P    E+  K
Sbjct: 856  KKDSKKEEAP--KKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAK 913

Query: 170  ADANDRDKPEPKATV---EEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVE 226
             +  +  KP+ K  V   E +DAK     +  ++KE + E K+   +E+AK   +K   E
Sbjct: 914  VEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKD-TKEEKAKKPEEKPKTE 972

Query: 227  DEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEK 277
             +AK      D K  +K  +K +A+  E++   ++ +   P +  E    K
Sbjct: 973  AKAK-----EDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAK 1018



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 62/231 (26%), Positives = 102/231 (44%), Gaps = 25/231 (10%)

Query: 20   EQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEKAPA--- 76
            E+ +  L ED    +P  + P+     +P +E +      + E  P +  ++EKAPA   
Sbjct: 797  EKAKSPLKEDAK--APEKEIPKKEEVKSPVKEEEKPQEVKVKE--PPKKAEEEKAPATPK 852

Query: 77   --EDGMSAELQGEANGLDEVKVESQREAGGKEDAEA--ELKKEDGEKEETTVGSQEMTGR 132
              E   S + +       + KVE ++E   ++  E+  E KKE+ E ++     ++    
Sbjct: 853  TEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPA 912

Query: 133  KEETKSEPKEAE-------EKESTLASEKQK-AEEKEAKPESGQKADANDRDKPEPKATV 184
            K E K + K  E       E +   A E  K AE+KEA PE     +   + KPE K   
Sbjct: 913  KVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAK-KPEEKPKT 971

Query: 185  E---EEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAE 232
            E   +ED KT S+E +  + E     K  +TD++     +KA  +  AK +
Sbjct: 972  EAKAKEDDKTLSKEPSKPKAE--KAEKSSSTDQKDSKPPEKATEDKAAKGK 1020



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 62/309 (20%), Positives = 132/309 (42%), Gaps = 41/309 (13%)

Query: 91  LDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEK-EST 149
           LD +   ++        A+ E+ +   + +  T   + +   K+  + +  E E++ ++ 
Sbjct: 297 LDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQAD 356

Query: 150 LASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEE-DAKTASQEETGQRKEC----- 203
           +AS ++  ++ +A+  + +   A    + +    V+   D + A+  +  + +EC     
Sbjct: 357 IASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFG 416

Query: 204 ----------------STEPKEKATDE---EAKAESQKAVVEDEAKAEPKEPDGKEEAKH 244
                           ST  K K+ ++     K+E +  +VE++ +      +  EE + 
Sbjct: 417 PIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEK 476

Query: 245 GAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNL 304
            AKEE   +EE  + EEAE G      E++ +  P   A    +SPE+  +SP  E    
Sbjct: 477 EAKEEEGKEEEGGEEEEAEGG------EEETKSPPAEEA----ASPEKEAKSPVKEEAKS 526

Query: 305 STDGLGPDCVASGQ----TSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPR 360
             +   P+   +       SP  ++S   +  +SPPE+ S  +++ K+P   V +P + +
Sbjct: 527 PAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSP-AEVKSPEKAK 585

Query: 361 GPRAQNRKA 369
            P  +  K+
Sbjct: 586 SPAKEEAKS 594


>gi|217330568 EH domain binding protein 1 isoform 1 [Homo sapiens]
          Length = 1231

 Score = 93.2 bits (230), Expect = 5e-19
 Identities = 93/370 (25%), Positives = 153/370 (41%), Gaps = 30/370 (8%)

Query: 141 KEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQR 200
           ++ E+ +    ++++KA +            + D D+ +         AK+AS  E    
Sbjct: 191 EDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANMRSAKSASSSEELIN 250

Query: 201 KECSTEPKEKATDEEAKAESQKAVVEDEAKAEP-KEPDGKEEAKHGAKEEADAKEEAEDA 259
           K    +  EK   + A   S      D A+  P  +PD +E        E  +  + ED+
Sbjct: 251 KLNFLDEAEK---DLATVNSNPFDDPDAAELNPFGDPDSEEPIT-----ETASPRKTEDS 302

Query: 260 EEAEPGSPSEE----QEQDVEKEPEGGAGVIPSSPEEWPES---PTGEGHNLSTDGLGPD 312
                 +P +E    Q  +   EPE    +  S P+        P      L  D     
Sbjct: 303 FYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYAD----- 357

Query: 313 CVASGQTSPSASESSPSDVPQS-PPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIV 371
             +S        ES+P   P+S PP +      +E   ERRV   A P  P    +  ++
Sbjct: 358 --SSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERRVKRKA-PAPPVLSPKTGVL 414

Query: 372 DKFGGAASGPTALFRNTKAAGAAIGGVK----NMLLEWCRAMTKKYEHVDIQNFSSSWSS 427
           ++   +A    +         + + G K      LL WC+ +TK Y  V I NF++SW +
Sbjct: 415 NENTVSAGKDLSTSPKPSPIPSPVLGRKPNASQSLLVWCKEVTKNYRGVKITNFTTSWRN 474

Query: 428 GMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDS 487
           G++FCA++H F PD  DY  L+P   + N   A+     +   ++LL+  DMV LA+PD 
Sbjct: 475 GLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIG-ISRLLEPSDMVLLAIPDK 533

Query: 488 KCVYTYIQEL 497
             V TY+ ++
Sbjct: 534 LTVMTYLYQI 543


>gi|4557241 actinin, alpha 3 [Homo sapiens]
          Length = 901

 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 43/102 (42%), Positives = 58/102 (56%)

Query: 399 KNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFT 458
           K  LL WC+  T  Y +V++QNF +SW  G+A CALIH+  PD  DYA+L       N  
Sbjct: 161 KEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLN 220

Query: 459 LAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRS 500
            AF  AEK  D  ++LD +D+V    PD K + TY+   Y +
Sbjct: 221 TAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHA 262


>gi|217330574 EH domain binding protein 1 isoform 3 [Homo sapiens]
          Length = 1160

 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 89/329 (27%), Positives = 141/329 (42%), Gaps = 30/329 (9%)

Query: 185 EEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVE----DEAKAEPKEPDGKE 240
           E++D    +QEE   +    TE   K    + +AE   A V     D+  A    P G  
Sbjct: 194 EDDDENRVNQEEKAAK---ITELINKLNFLD-EAEKDLATVNSNPFDDPDAAELNPFGDP 249

Query: 241 EAKHGAKEEADAKEEAEDAEEAEPGSPSEE----QEQDVEKEPEGGAGVIPSSPEEWPES 296
           +++    E A  ++  ED+      +P +E    Q  +   EPE    +  S P+     
Sbjct: 250 DSEEPITETASPRK-TEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRK 308

Query: 297 ---PTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQS-PPESPSSGEKKEKAPERR 352
              P      L  D       +S        ES+P   P+S PP +      +E   ERR
Sbjct: 309 NIRPVDMSKYLYAD-------SSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERR 361

Query: 353 VSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVK----NMLLEWCRA 408
           V   A P  P    +  ++++   +A    +         + + G K      LL WC+ 
Sbjct: 362 VKRKA-PAPPVLSPKTGVLNENTVSAGKDLSTSPKPSPIPSPVLGRKPNASQSLLVWCKE 420

Query: 409 MTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLA 468
           +TK Y  V I NF++SW +G++FCA++H F PD  DY  L+P   + N   A+     + 
Sbjct: 421 VTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIG 480

Query: 469 DCAQLLDVDDMVRLAVPDSKCVYTYIQEL 497
             ++LL+  DMV LA+PD   V TY+ ++
Sbjct: 481 -ISRLLEPSDMVLLAIPDKLTVMTYLYQI 508


>gi|217330572 EH domain binding protein 1 isoform 3 [Homo sapiens]
          Length = 1160

 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 89/329 (27%), Positives = 141/329 (42%), Gaps = 30/329 (9%)

Query: 185 EEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVE----DEAKAEPKEPDGKE 240
           E++D    +QEE   +    TE   K    + +AE   A V     D+  A    P G  
Sbjct: 194 EDDDENRVNQEEKAAK---ITELINKLNFLD-EAEKDLATVNSNPFDDPDAAELNPFGDP 249

Query: 241 EAKHGAKEEADAKEEAEDAEEAEPGSPSEE----QEQDVEKEPEGGAGVIPSSPEEWPES 296
           +++    E A  ++  ED+      +P +E    Q  +   EPE    +  S P+     
Sbjct: 250 DSEEPITETASPRK-TEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRK 308

Query: 297 ---PTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQS-PPESPSSGEKKEKAPERR 352
              P      L  D       +S        ES+P   P+S PP +      +E   ERR
Sbjct: 309 NIRPVDMSKYLYAD-------SSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERR 361

Query: 353 VSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVK----NMLLEWCRA 408
           V   A P  P    +  ++++   +A    +         + + G K      LL WC+ 
Sbjct: 362 VKRKA-PAPPVLSPKTGVLNENTVSAGKDLSTSPKPSPIPSPVLGRKPNASQSLLVWCKE 420

Query: 409 MTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLA 468
           +TK Y  V I NF++SW +G++FCA++H F PD  DY  L+P   + N   A+     + 
Sbjct: 421 VTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIG 480

Query: 469 DCAQLLDVDDMVRLAVPDSKCVYTYIQEL 497
             ++LL+  DMV LA+PD   V TY+ ++
Sbjct: 481 -ISRLLEPSDMVLLAIPDKLTVMTYLYQI 508


>gi|217330570 EH domain binding protein 1 isoform 2 [Homo sapiens]
          Length = 1196

 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 89/329 (27%), Positives = 141/329 (42%), Gaps = 30/329 (9%)

Query: 185 EEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVE----DEAKAEPKEPDGKE 240
           E++D    +QEE   +    TE   K    + +AE   A V     D+  A    P G  
Sbjct: 194 EDDDENRVNQEEKAAK---ITELINKLNFLD-EAEKDLATVNSNPFDDPDAAELNPFGDP 249

Query: 241 EAKHGAKEEADAKEEAEDAEEAEPGSPSEE----QEQDVEKEPEGGAGVIPSSPEEWPES 296
           +++    E A  ++  ED+      +P +E    Q  +   EPE    +  S P+     
Sbjct: 250 DSEEPITETASPRK-TEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRK 308

Query: 297 ---PTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQS-PPESPSSGEKKEKAPERR 352
              P      L  D       +S        ES+P   P+S PP +      +E   ERR
Sbjct: 309 NIRPVDMSKYLYAD-------SSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERR 361

Query: 353 VSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVK----NMLLEWCRA 408
           V   A P  P    +  ++++   +A    +         + + G K      LL WC+ 
Sbjct: 362 VKRKA-PAPPVLSPKTGVLNENTVSAGKDLSTSPKPSPIPSPVLGRKPNASQSLLVWCKE 420

Query: 409 MTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLA 468
           +TK Y  V I NF++SW +G++FCA++H F PD  DY  L+P   + N   A+     + 
Sbjct: 421 VTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIG 480

Query: 469 DCAQLLDVDDMVRLAVPDSKCVYTYIQEL 497
             ++LL+  DMV LA+PD   V TY+ ++
Sbjct: 481 -ISRLLEPSDMVLLAIPDKLTVMTYLYQI 508


>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
          Length = 887

 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 43/102 (42%), Positives = 58/102 (56%)

Query: 399 KNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFT 458
           K  LL WC+  T  Y++V+IQNF  SW  G+ FCALIH+  P+  DY +L       N  
Sbjct: 147 KEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLN 206

Query: 459 LAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRS 500
            AF  AEK  D  ++LD +D+V  A PD K + TY+   Y +
Sbjct: 207 TAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA 248


>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
          Length = 914

 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 43/102 (42%), Positives = 58/102 (56%)

Query: 399 KNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFT 458
           K  LL WC+  T  Y++V+IQNF  SW  G+ FCALIH+  P+  DY +L       N  
Sbjct: 147 KEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLN 206

Query: 459 LAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRS 500
            AF  AEK  D  ++LD +D+V  A PD K + TY+   Y +
Sbjct: 207 TAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA 248


>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
          Length = 892

 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 43/102 (42%), Positives = 58/102 (56%)

Query: 399 KNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFT 458
           K  LL WC+  T  Y++V+IQNF  SW  G+ FCALIH+  P+  DY +L       N  
Sbjct: 147 KEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLN 206

Query: 459 LAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRS 500
            AF  AEK  D  ++LD +D+V  A PD K + TY+   Y +
Sbjct: 207 TAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA 248


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 92.4 bits (228), Expect = 9e-19
 Identities = 99/325 (30%), Positives = 146/325 (44%), Gaps = 50/325 (15%)

Query: 64  PPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKE-DGEKEET 122
           P T S K +K   E   + +L+ +   ++E+  E++      ED ++E+++      EE 
Sbjct: 429 PITISSKIQKPKVE---APKLKVQHKFVEEIIEETK-----VEDEKSEMEEALTAITEEL 480

Query: 123 TVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKA 182
            V  +E      E K E  EAEE+E        KA   E K E G+K +   +++ E   
Sbjct: 481 AVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEE-- 538

Query: 183 TVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEA 242
             E+E AK+   EE G  KE S+E KE+   EE          E EA+AE +E + KEE 
Sbjct: 539 --EDEGAKSDQAEEGGSEKEGSSE-KEEGEQEEG---------ETEAEAEGEEAEAKEEK 586

Query: 243 KHGAKEE---------ADAK-EEAEDAEEAEPGSPSEEQ-EQDVEKEP--EGGAGVIPSS 289
           K   K E         ADAK E+ E A+   P SP EE+ +  V K P  E G   +P S
Sbjct: 587 KVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 646

Query: 290 P-EEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSS------G 342
           P EE  +SP  +   +   G  P       +     E + S VP+SP E   S      G
Sbjct: 647 PVEEKGKSPVPKS-PVEEKGKSP------VSKSPVEEKAKSPVPKSPVEEAKSKAEVGKG 699

Query: 343 EKKEKAPERRVSAPARPRGPRAQNR 367
           E+KE+  +    AP   +  + + +
Sbjct: 700 EQKEEEEKEVKEAPKEEKVEKKEEK 724



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 81/334 (24%), Positives = 142/334 (42%), Gaps = 42/334 (12%)

Query: 70  KQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEM 129
           + EK+  E+ ++A  +  A  + E K    +EA  +++ E E ++E+   +++ V +   
Sbjct: 463 EDEKSEMEEALTAITEELAVSMKEEK----KEAAEEKEEEPEAEEEEVAAKKSPVKATAP 518

Query: 130 TGRKEETKSEPKEA--EEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEE 187
             ++EE + E +E   EE+E    ++  +AEE  ++ E   + +  ++++ E +A  E E
Sbjct: 519 EVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGE 578

Query: 188 DAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAK 247
           +A+   +++  ++ E      E AT EE  A+   A VE   KA  K P  K   +   K
Sbjct: 579 EAEAKEEKKVEEKSE------EVATKEELVAD---AKVEKPEKA--KSPVPKSPVEEKGK 627

Query: 248 EEADAKEEAEDAEEAEPGSPSEEQ-EQDVEKEP--EGGAGVIPSSPEE------WPESPT 298
                    E  +   P SP EE+ +  V K P  E G   +  SP E       P+SP 
Sbjct: 628 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPV 687

Query: 299 GEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPAR 358
            E  + +  G G              E    +V ++P E     EK EK  E+    P +
Sbjct: 688 EEAKSKAEVGKG-----------EQKEEEEKEVKEAPKE-----EKVEKKEEKPKDVPEK 731

Query: 359 PRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAG 392
            +       +A+ +      S    L + TK  G
Sbjct: 732 KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEG 765



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 94/348 (27%), Positives = 145/348 (41%), Gaps = 27/348 (7%)

Query: 15  AREKMEQKEGKLSEDGTTVSPA-ADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEK 73
           A EK E+ E +  E     SP  A  PE+       EE +G   +   +        +E 
Sbjct: 492 AEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEG 551

Query: 74  APAEDGMSAELQGEAN-GLDEVKVESQREAGGKEDAEAELKKED-GEKEETTVGSQEMTG 131
              ++G S + +GE   G  E + E + EA  KE+ + E K E+   KEE    ++    
Sbjct: 552 GSEKEGSSEKEEGEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATKEELVADAK--VE 608

Query: 132 RKEETKSE-PKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDK-PEPKATVEEEDA 189
           + E+ KS  PK   E++      K   EEK   P    K+   ++ K P PK+ VEE+  
Sbjct: 609 KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV--PKSPVEEKGKSPVPKSPVEEKGK 666

Query: 190 KTASQEETGQRKECSTEPKEKATDEEAKAE----SQKAVVEDEAKAEPKEP--DGKEEAK 243
              S+    + K  S  PK    + ++KAE     QK   E E K  PKE   + KEE  
Sbjct: 667 SPVSKSPV-EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP 725

Query: 244 HGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKE-PEGGAGVIPSSPEEWPESPTGEGH 302
               E+  A+   ++   AE  + ++  +  +EKE  E G    P   E+  E   GEG 
Sbjct: 726 KDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGK---PLQQEKEKEKAGGEG- 781

Query: 303 NLSTDGLGPDCVASGQTSPSAS---ESSPSDVPQSPPESPSSGEKKEK 347
              ++  G D  A G      +   E    +  +   +   SG ++EK
Sbjct: 782 --GSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 827



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 84/300 (28%), Positives = 129/300 (43%), Gaps = 43/300 (14%)

Query: 5   AVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGP 64
           A+ E    +   EK E  E K  E      P A+  E++   +P + T     +      
Sbjct: 475 AITEELAVSMKEEKKEAAEEKEEE------PEAEEEEVAAKKSPVKATAPEVKE------ 522

Query: 65  PTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTV 124
             E G++E+   E+G     Q E    DE     Q E GG E  E   +KE+GE+EE   
Sbjct: 523 --EEGEKEE---EEG-----QEEEEEEDEGAKSDQAEEGGSEK-EGSSEKEEGEQEEG-- 569

Query: 125 GSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDK---PEPK 181
                   + E ++E +EAE KE     EK  +EE   K E    A     +K   P PK
Sbjct: 570 --------ETEAEAEGEEAEAKEEKKVEEK--SEEVATKEELVADAKVEKPEKAKSPVPK 619

Query: 182 ATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEE 241
           + VEE+  K+   +   + K  S  PK    +E+ K+   K+ VE++ K+   +   +E+
Sbjct: 620 SPVEEK-GKSPVPKSPVEEKGKSPVPK-SPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEK 677

Query: 242 AKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEP-EGGAGVIPSSPEEWPESPTGE 300
           AK    +     EEA+   E   G   EE+E++V++ P E         P++ PE    E
Sbjct: 678 AKSPVPK--SPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAE 735



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 79/319 (24%), Positives = 128/319 (40%), Gaps = 60/319 (18%)

Query: 7   GESDCSAEAREKMEQKEGKLSEDGTTVSPA--------ADNPEMSGGGAPAEETKGTAGK 58
           GE++  AE  E   ++E K+ E    V+           + PE +    P    +     
Sbjct: 569 GETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKS 628

Query: 59  AINEGPPTESGKQE--KAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKED 116
            + + P  E GK    K+P E+   + +            +S  E  GK        +E 
Sbjct: 629 PVPKSPVEEKGKSPVPKSPVEEKGKSPVP-----------KSPVEEKGKSPVSKSPVEEK 677

Query: 117 GEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRD 176
            +        +E   + E  K E KE EEKE   A +++K E+KE KP+     D  ++ 
Sbjct: 678 AKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPK-----DVPEKK 732

Query: 177 KPEPKATVEEE----------DAKTASQEETGQRKECSTEPKEK-------ATDEEAKAE 219
           K E  + V+EE            K   ++ET +  +   + KEK        ++EE   +
Sbjct: 733 KAE--SPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK 790

Query: 220 SQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAE----------DAEEAEPGSPSE 269
             K   +++  A   E +GKEE +   KE+   +EE +           A+E + G  SE
Sbjct: 791 GAKGSRKEDI-AVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSE 849

Query: 270 EQ---EQDVEK-EPEGGAG 284
           E+    + VEK   EGG G
Sbjct: 850 EKVVVTKTVEKITSEGGDG 868


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 92.4 bits (228), Expect = 9e-19
 Identities = 99/325 (30%), Positives = 146/325 (44%), Gaps = 50/325 (15%)

Query: 64  PPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKE-DGEKEET 122
           P T S K +K   E   + +L+ +   ++E+  E++      ED ++E+++      EE 
Sbjct: 53  PITISSKIQKPKVE---APKLKVQHKFVEEIIEETK-----VEDEKSEMEEALTAITEEL 104

Query: 123 TVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKA 182
            V  +E      E K E  EAEE+E        KA   E K E G+K +   +++ E   
Sbjct: 105 AVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEE-- 162

Query: 183 TVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEA 242
             E+E AK+   EE G  KE S+E KE+   EE          E EA+AE +E + KEE 
Sbjct: 163 --EDEGAKSDQAEEGGSEKEGSSE-KEEGEQEEG---------ETEAEAEGEEAEAKEEK 210

Query: 243 KHGAKEE---------ADAK-EEAEDAEEAEPGSPSEEQ-EQDVEKEP--EGGAGVIPSS 289
           K   K E         ADAK E+ E A+   P SP EE+ +  V K P  E G   +P S
Sbjct: 211 KVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 270

Query: 290 P-EEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSS------G 342
           P EE  +SP  +   +   G  P       +     E + S VP+SP E   S      G
Sbjct: 271 PVEEKGKSPVPKS-PVEEKGKSP------VSKSPVEEKAKSPVPKSPVEEAKSKAEVGKG 323

Query: 343 EKKEKAPERRVSAPARPRGPRAQNR 367
           E+KE+  +    AP   +  + + +
Sbjct: 324 EQKEEEEKEVKEAPKEEKVEKKEEK 348



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 81/334 (24%), Positives = 142/334 (42%), Gaps = 42/334 (12%)

Query: 70  KQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEM 129
           + EK+  E+ ++A  +  A  + E K    +EA  +++ E E ++E+   +++ V +   
Sbjct: 87  EDEKSEMEEALTAITEELAVSMKEEK----KEAAEEKEEEPEAEEEEVAAKKSPVKATAP 142

Query: 130 TGRKEETKSEPKEA--EEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEE 187
             ++EE + E +E   EE+E    ++  +AEE  ++ E   + +  ++++ E +A  E E
Sbjct: 143 EVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGE 202

Query: 188 DAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAK 247
           +A+   +++  ++ E      E AT EE  A+   A VE   KA  K P  K   +   K
Sbjct: 203 EAEAKEEKKVEEKSE------EVATKEELVAD---AKVEKPEKA--KSPVPKSPVEEKGK 251

Query: 248 EEADAKEEAEDAEEAEPGSPSEEQ-EQDVEKEP--EGGAGVIPSSPEE------WPESPT 298
                    E  +   P SP EE+ +  V K P  E G   +  SP E       P+SP 
Sbjct: 252 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPV 311

Query: 299 GEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPAR 358
            E  + +  G G              E    +V ++P E     EK EK  E+    P +
Sbjct: 312 EEAKSKAEVGKG-----------EQKEEEEKEVKEAPKE-----EKVEKKEEKPKDVPEK 355

Query: 359 PRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAG 392
            +       +A+ +      S    L + TK  G
Sbjct: 356 KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEG 389



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 94/348 (27%), Positives = 145/348 (41%), Gaps = 27/348 (7%)

Query: 15  AREKMEQKEGKLSEDGTTVSPA-ADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEK 73
           A EK E+ E +  E     SP  A  PE+       EE +G   +   +        +E 
Sbjct: 116 AEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEG 175

Query: 74  APAEDGMSAELQGEAN-GLDEVKVESQREAGGKEDAEAELKKED-GEKEETTVGSQEMTG 131
              ++G S + +GE   G  E + E + EA  KE+ + E K E+   KEE    ++    
Sbjct: 176 GSEKEGSSEKEEGEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATKEELVADAK--VE 232

Query: 132 RKEETKSE-PKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDK-PEPKATVEEEDA 189
           + E+ KS  PK   E++      K   EEK   P    K+   ++ K P PK+ VEE+  
Sbjct: 233 KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV--PKSPVEEKGKSPVPKSPVEEKGK 290

Query: 190 KTASQEETGQRKECSTEPKEKATDEEAKAE----SQKAVVEDEAKAEPKEP--DGKEEAK 243
              S+    + K  S  PK    + ++KAE     QK   E E K  PKE   + KEE  
Sbjct: 291 SPVSKSPV-EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP 349

Query: 244 HGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKE-PEGGAGVIPSSPEEWPESPTGEGH 302
               E+  A+   ++   AE  + ++  +  +EKE  E G    P   E+  E   GEG 
Sbjct: 350 KDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGK---PLQQEKEKEKAGGEG- 405

Query: 303 NLSTDGLGPDCVASGQTSPSAS---ESSPSDVPQSPPESPSSGEKKEK 347
              ++  G D  A G      +   E    +  +   +   SG ++EK
Sbjct: 406 --GSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 451



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 84/300 (28%), Positives = 129/300 (43%), Gaps = 43/300 (14%)

Query: 5   AVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGP 64
           A+ E    +   EK E  E K  E      P A+  E++   +P + T     +      
Sbjct: 99  AITEELAVSMKEEKKEAAEEKEEE------PEAEEEEVAAKKSPVKATAPEVKE------ 146

Query: 65  PTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTV 124
             E G++E+   E+G     Q E    DE     Q E GG E  E   +KE+GE+EE   
Sbjct: 147 --EEGEKEE---EEG-----QEEEEEEDEGAKSDQAEEGGSEK-EGSSEKEEGEQEEG-- 193

Query: 125 GSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDK---PEPK 181
                   + E ++E +EAE KE     EK  +EE   K E    A     +K   P PK
Sbjct: 194 --------ETEAEAEGEEAEAKEEKKVEEK--SEEVATKEELVADAKVEKPEKAKSPVPK 243

Query: 182 ATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEE 241
           + VEE+  K+   +   + K  S  PK    +E+ K+   K+ VE++ K+   +   +E+
Sbjct: 244 SPVEEK-GKSPVPKSPVEEKGKSPVPK-SPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEK 301

Query: 242 AKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEP-EGGAGVIPSSPEEWPESPTGE 300
           AK    +     EEA+   E   G   EE+E++V++ P E         P++ PE    E
Sbjct: 302 AKSPVPK--SPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAE 359



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 79/319 (24%), Positives = 128/319 (40%), Gaps = 60/319 (18%)

Query: 7   GESDCSAEAREKMEQKEGKLSEDGTTVSPA--------ADNPEMSGGGAPAEETKGTAGK 58
           GE++  AE  E   ++E K+ E    V+           + PE +    P    +     
Sbjct: 193 GETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKS 252

Query: 59  AINEGPPTESGKQE--KAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKED 116
            + + P  E GK    K+P E+   + +            +S  E  GK        +E 
Sbjct: 253 PVPKSPVEEKGKSPVPKSPVEEKGKSPVP-----------KSPVEEKGKSPVSKSPVEEK 301

Query: 117 GEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRD 176
            +        +E   + E  K E KE EEKE   A +++K E+KE KP+     D  ++ 
Sbjct: 302 AKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPK-----DVPEKK 356

Query: 177 KPEPKATVEEE----------DAKTASQEETGQRKECSTEPKEK-------ATDEEAKAE 219
           K E  + V+EE            K   ++ET +  +   + KEK        ++EE   +
Sbjct: 357 KAE--SPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK 414

Query: 220 SQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAE----------DAEEAEPGSPSE 269
             K   +++  A   E +GKEE +   KE+   +EE +           A+E + G  SE
Sbjct: 415 GAKGSRKEDI-AVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSE 473

Query: 270 EQ---EQDVEK-EPEGGAG 284
           E+    + VEK   EGG G
Sbjct: 474 EKVVVTKTVEKITSEGGDG 492


>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
          Length = 3639

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 48/108 (44%), Positives = 60/108 (55%), Gaps = 1/108 (0%)

Query: 391 AGAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDP 450
           A AA+   K  LL WC+  T  Y +V+I +FS SWS G+ F ALIH   PD  DY  L P
Sbjct: 137 ASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRP 196

Query: 451 AKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELY 498
            +  HN   AF  AE+    AQLLD +D V  A PD + + TY+   Y
Sbjct: 197 DRPLHNLAFAFLVAEQELGIAQLLDPED-VAAAQPDERSIMTYVSLYY 243


>gi|4501893 actinin, alpha 2 [Homo sapiens]
          Length = 894

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 41/102 (40%), Positives = 58/102 (56%)

Query: 399 KNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFT 458
           K  LL WC+  T  Y +V+IQNF +SW  G+  CALIH+  PD  DY++L+      N  
Sbjct: 154 KEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNIN 213

Query: 459 LAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRS 500
           LA   AEK  D  ++LD +D+V    PD + + TY+   Y +
Sbjct: 214 LAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHA 255


>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1
           [Homo sapiens]
          Length = 2564

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 43/100 (43%), Positives = 61/100 (61%), Gaps = 1/100 (1%)

Query: 399 KNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFT 458
           K+ LL WC+  T  Y  V+IQNF++SW  G+AF ALIH+  PD  D+++L  +   +N  
Sbjct: 183 KDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANYNLQ 242

Query: 459 LAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELY 498
            AF TAE+    A+LLD +D V +  PD K + TY+   Y
Sbjct: 243 RAFRTAEQHLGLARLLDPED-VNMEAPDEKSIITYVVSFY 281



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 20/64 (31%), Positives = 34/64 (53%), Gaps = 3/64 (4%)

Query: 317  GQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQ--NRKAIVDKF 374
            G+  P+A  ++P D  ++P  +P++ E+    PER+ SA      PR +   R+  VD+ 
Sbjct: 2200 GRVEPAALPAAPEDAAETPA-TPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQS 2258

Query: 375  GGAA 378
              AA
Sbjct: 2259 EEAA 2262


>gi|67782321 spectrin beta isoform a [Homo sapiens]
          Length = 2328

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 45/107 (42%), Positives = 59/107 (55%), Gaps = 1/107 (0%)

Query: 392 GAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPA 451
           G      K+ LL WC+  T  Y HV++ NF+SSW  G+AF ALIHK  PD  D+ +L  +
Sbjct: 169 GRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDS 228

Query: 452 KRRHNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELY 498
             RHN   AF+ AE+      LLD +D V    PD K + TY+   Y
Sbjct: 229 NARHNLEHAFNVAERQLGIIPLLDPED-VFTENPDEKSIITYVVAFY 274


>gi|67782319 spectrin beta isoform b [Homo sapiens]
          Length = 2137

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 45/107 (42%), Positives = 59/107 (55%), Gaps = 1/107 (0%)

Query: 392 GAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPA 451
           G      K+ LL WC+  T  Y HV++ NF+SSW  G+AF ALIHK  PD  D+ +L  +
Sbjct: 169 GRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDS 228

Query: 452 KRRHNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELY 498
             RHN   AF+ AE+      LLD +D V    PD K + TY+   Y
Sbjct: 229 NARHNLEHAFNVAERQLGIIPLLDPED-VFTENPDEKSIITYVVAFY 274


>gi|12025678 actinin, alpha 4 [Homo sapiens]
          Length = 911

 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 41/102 (40%), Positives = 58/102 (56%)

Query: 399 KNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFT 458
           K  LL WC+  T  Y++V++QNF  SW  G+AF ALIH+  P+  +Y +L       N  
Sbjct: 166 KEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLN 225

Query: 459 LAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRS 500
            AF  AEK  D  ++LD +D+V  A PD K + TY+   Y +
Sbjct: 226 NAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHA 267


>gi|31324577 molecule interacting with Rab13 [Homo sapiens]
          Length = 863

 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 42/111 (37%), Positives = 60/111 (54%)

Query: 395 IGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRR 454
           + G +  LL WCR   + Y  V+I++ SSS+  G+AFCA++H+  PD  D+  L      
Sbjct: 1   MAGPRGALLAWCRRQCEGYRGVEIRDLSSSFRDGLAFCAILHRHRPDLLDFDSLSKDNVF 60

Query: 455 HNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRSLVQKG 505
            N  LAF  AEK      LLD +DMV ++VPD   + TY+ + Y      G
Sbjct: 61  ENNRLAFEVAEKELGIPALLDPNDMVSMSVPDCLSIMTYVSQYYNHFCSPG 111



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 78/378 (20%), Positives = 133/378 (35%), Gaps = 53/378 (14%)

Query: 48  PAEETKGTAGKAINEGPPTESG------KQEKAPAEDGMSAELQGEANGLDEVKVESQRE 101
           P E T   A      GP T SG       Q K   +  ++ + +    G       +  E
Sbjct: 207 PEEGTFVCAEHCARLGPGTRSGTRPGPFSQPKQQHQQQLAEDAKDVPGGGPSSSAPAGAE 266

Query: 102 AGGKEDAEAELKKEDGEKEETTVGSQEMT----GRKEETKSEPKEAEEKESTLASEKQKA 157
           A G + A  E + +   K       QE+     GR      +  E+          +   
Sbjct: 267 ADGPK-ASPEARPQIPTKPRVPGKLQELASPPAGRPTPAPRKASESTTPAPPTPRPRSSL 325

Query: 158 EEKEAKPESGQKADANDR----DKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATD 213
           +++    ++G  +  N R      P+P+ T +  +   A +++         EPK+K   
Sbjct: 326 QQENLVEQAGSSSLVNGRLHELPVPKPRGTPKPSEGTPAPRKDPPWITLVQAEPKKKP-- 383

Query: 214 EEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQ 273
                    A +   +   P   D ++    G +E A     A  + E++P +P EE+E+
Sbjct: 384 ---------APLPPSSSPGPPSQDSRQVENGGTEEVAQPSPTA--SLESKPYNPFEEEEE 432

Query: 274 DVEKEPEGGAGVIPS----SPEEWPES--------PTGEGHNLSTDGLGPDCVASGQTSP 321
           D E+E      +  S     PE  P+S        PT            P   ++   + 
Sbjct: 433 DKEEEAPAAPSLATSPALGHPESTPKSLHPWYGITPTSSPKTKKRP--APRAPSASPLAL 490

Query: 322 SASESSPSDVPQSPP------ESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVDKFG 375
            AS  S S+ P + P      ES SS    + A    +  PA    P++ +  A+     
Sbjct: 491 HASRLSHSEPPSATPSPALSVESLSSESASQTAGAELLEPPA---VPKSSSEPAV--HAP 545

Query: 376 GAASGPTALFRNTKAAGA 393
           G    P +L  N+  A +
Sbjct: 546 GTPGNPVSLSTNSSLASS 563



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 33/147 (22%), Positives = 56/147 (38%), Gaps = 18/147 (12%)

Query: 214 EEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQ 273
           E    E      E  A+  P    G         ++   ++ AEDA++   G PS     
Sbjct: 204 ENGPEEGTFVCAEHCARLGPGTRSGTRPGPFSQPKQQHQQQLAEDAKDVPGGGPSSSAPA 263

Query: 274 DVEKEPEGGAGVIPSSPEEWPESPT-----GEGHNLSTDGLGPDCVASGQTSPSASESSP 328
             E +         +SPE  P+ PT     G+   L++         +G+ +P+  ++S 
Sbjct: 264 GAEADGP------KASPEARPQIPTKPRVPGKLQELASP-------PAGRPTPAPRKASE 310

Query: 329 SDVPQSPPESPSSGEKKEKAPERRVSA 355
           S  P  P   P S  ++E   E+  S+
Sbjct: 311 STTPAPPTPRPRSSLQQENLVEQAGSS 337


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.300    0.121    0.330 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,054,998
Number of Sequences: 37866
Number of extensions: 1458679
Number of successful extensions: 39452
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 940
Number of HSP's successfully gapped in prelim test: 1924
Number of HSP's that attempted gapping in prelim test: 9566
Number of HSP's gapped (non-prelim): 12975
length of query: 512
length of database: 18,247,518
effective HSP length: 107
effective length of query: 405
effective length of database: 14,195,856
effective search space: 5749321680
effective search space used: 5749321680
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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