Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 157427675
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
(837 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 1764 0.0
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 803 0.0
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 726 0.0
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 685 0.0
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 580 e-165
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 556 e-158
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 547 e-155
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 426 e-119
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 399 e-111
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 380 e-105
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 376 e-104
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 361 2e-99
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 352 1e-96
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 338 2e-92
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 331 1e-90
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 325 1e-88
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 325 1e-88
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 313 5e-85
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 309 6e-84
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 268 1e-71
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 268 1e-71
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 244 2e-64
gi|226442878 ADAMTS-like 5 [Homo sapiens] 169 1e-41
gi|145309328 papilin [Homo sapiens] 161 2e-39
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 156 9e-38
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 156 9e-38
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 155 1e-37
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 155 1e-37
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 135 2e-31
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens] 135 2e-31
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 1764 bits (4570), Expect = 0.0
Identities = 837/837 (100%), Positives = 837/837 (100%)
Query: 1 MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEE 60
MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEE
Sbjct: 1 MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEE 60
Query: 61 IVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLG 120
IVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLG
Sbjct: 61 IVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLG 120
Query: 121 GAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHI 180
GAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHI
Sbjct: 121 GAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHI 180
Query: 181 LRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKR 240
LRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKR
Sbjct: 181 LRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKR 240
Query: 241 YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLN 300
YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLN
Sbjct: 241 YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLN 300
Query: 301 TPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAA 360
TPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAA
Sbjct: 301 TPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAA 360
Query: 361 HELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGY 420
HELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGY
Sbjct: 361 HELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGY 420
Query: 421 GHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHA 480
GHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHA
Sbjct: 421 GHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHA 480
Query: 481 MCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGV 540
MCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGV
Sbjct: 481 MCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGV 540
Query: 541 QFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSF 600
QFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSF
Sbjct: 541 QFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSF 600
Query: 601 PGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHA 660
PGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHA
Sbjct: 601 PGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHA 660
Query: 661 GCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNP 720
GCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNP
Sbjct: 661 GCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNP 720
Query: 721 GHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQP 780
GHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQP
Sbjct: 721 GHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQP 780
Query: 781 LTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK 837
LTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK
Sbjct: 781 LTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK 837
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 803 bits (2073), Expect = 0.0
Identities = 411/837 (49%), Positives = 538/837 (64%), Gaps = 68/837 (8%)
Query: 37 LLLLLLASLLPSARLASPLPREEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLEL 96
LLLL A L S L P +EE+V PE PG G RL RL AF + L LEL
Sbjct: 36 LLLLAAALLAVSDALGRPSEEDEELVVPELERA---PGHGT-TRL--RLHAFDQQLDLEL 89
Query: 97 EQDSGVQVEGLTVQYLGQAPELLGGAE---PGT-----YLTGTINGDPESVASLHWDGGA 148
DS G T+Q +G+ G+E P T + +GT+NGDP S A+L G
Sbjct: 90 RPDSSFLAPGFTLQNVGRK----SGSETPLPETDLAHCFYSGTVNGDPSSAAALSLCEG- 144
Query: 149 LLGVLQYRGAELHLQPLEGGTPNSA-GGPGA--------HILRRK--------------- 184
+ G G +QPL + A PG H+LRR
Sbjct: 145 VRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQGDVGGTCGVVDDE 204
Query: 185 ---------------SPASGQGPMCNVKAP----LGSPSPRPR-RAKRFASLSRFVETLV 224
+ +G + + P +G P+ R KRF S R+VET++
Sbjct: 205 PRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSIRKKRFVSSHRYVETML 264
Query: 225 VADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPS 284
VAD MA FHG+GLK YLLT+ + AA+ +KHPSIRN VSLVV +++++ ++GP+V +
Sbjct: 265 VADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSN 324
Query: 285 AAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARS 344
AA TLR+FC WQ+ N P D D +H+DTAILFTRQDLCG TCDTLGMADVGTVCDP+RS
Sbjct: 325 AALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADVGTVCDPSRS 384
Query: 345 CAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPW 404
C+++EDDGLQ+AFT AHELGHVFNM HD++K C SLNG ++ H+MA +++++D +PW
Sbjct: 385 CSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNG-VNQDSHMMASMLSNLDHSQPW 443
Query: 405 SPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLP 464
SPCSA IT FLDNG+G CL+DKP+ P+ LP PG YDA+RQCQ TFG DS+HCP
Sbjct: 444 SPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAA 503
Query: 465 PPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWG 524
C+ LWC+G G +CQTKH PWADGT CG + C+ G+C++ + F+ P G WG
Sbjct: 504 STCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTDRKHFDTPFHGSWG 563
Query: 525 PWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFRE 584
WGPWGDCSRTCGGGVQ++ R+C PVP+NGGKYCEG+R R+RSCN EDCP + TFRE
Sbjct: 564 MWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFRE 623
Query: 585 EQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPC 644
EQC A+N + ++W+P+Y GV+P+D+CKL CQA+ +GY++VL+P+VVDGTPC
Sbjct: 624 EQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPC 683
Query: 645 SPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVT 704
SPDS+SVCVQG+C+ AGCDRII SKKKFDKC VCGG+GS C K SGS + GY++++T
Sbjct: 684 SPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHDIIT 743
Query: 705 IPAGATHILVRQQGNPGHRS--IYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYS 762
IP GAT+I V+Q+ G R+ +LA+K DG+Y LNG+YTL D++ G V LRYS
Sbjct: 744 IPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVV-LRYS 802
Query: 763 GATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPRPTPS-TPRPTPQDWL 818
G++AA E + PL +PLT+QVL GN +++Y++FV + S PT W+
Sbjct: 803 GSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFSAWV 859
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 726 bits (1874), Expect = 0.0
Identities = 377/820 (45%), Positives = 499/820 (60%), Gaps = 46/820 (5%)
Query: 37 LLLLLLASLLPSARLASPLPREEEIVFPEKLNGSVL--------PGSGAPARLLCRLQAF 88
+LLL + +L + R A E E+V P +L+ + P L+ ++ AF
Sbjct: 1 MLLLGILTLAFAGRTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQITAF 60
Query: 89 GETLLLELEQDSGVQVEGLTVQYLGQAPELLGGAEPGT---YLTGTINGDPESVASLHWD 145
E L L D+ + ++LG + L G + +G +N +P+S A++
Sbjct: 61 QEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAAVSLC 120
Query: 146 GGALLGVLQYRGAELHLQPLEGGTPNSA--GGPGAHILRRKS----PASGQGPMCNV--- 196
GG L G YRGAE + PL + +A GAH+L+R+ P+ C V
Sbjct: 121 GG-LRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVASG 179
Query: 197 ---------------KAPLGSPSPRPR--RAKRFASLSRFVETLVVADDKMAAFHGAGLK 239
+A G R R RAKRF S+ R+VETLVVAD+ M FHGA L+
Sbjct: 180 WNPAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLE 239
Query: 240 RYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGL 299
YLLT++A AA+ ++HPSI NP+++VV ++++L + GP+V +AA TLR+FCAWQ+ L
Sbjct: 240 HYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKL 299
Query: 300 NTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTA 359
N D P+++DTAILFTRQDLCG +TCDTLGMADVGT+CDP RSC+++EDDGL SAFT
Sbjct: 300 NKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTT 359
Query: 360 AHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNG 419
AHELGHVFNM HDN K C + G L + H+M+P + +D PWS CSA ITDFLD+G
Sbjct: 360 AHELGHVFNMPHDNVKVCEEVFGKL-RANHMMSPTLIQIDRANPWSACSAAIITDFLDSG 418
Query: 420 YGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGH 479
+G CLLD+P P+ LP PG Y +QC+L FG S+ CP + C LWC+G G
Sbjct: 419 HGDCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPYM-QYCTKLWCTGKAKGQ 477
Query: 480 AMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGG 539
+CQT+H PWADGT CG + C+ G C+ L + G W W P+G CSRTCGGG
Sbjct: 478 MVCQTRHFPWADGTSCGEGKLCLKGACVERHNLNKHRVD--GSWAKWDPYGPCSRTCGGG 535
Query: 540 VQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCP-TGSALTFREEQCAAYNHRTDLFK 598
VQ + R CT P P NGGKYCEG R ++RSCN E CP + S +FREEQC A+N
Sbjct: 536 VQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTN 595
Query: 599 SFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCI 658
+ WVP+Y+GV+P+D+CKL C+A GY+YVL P+VVDGT CSPDS+SVCVQG+CI
Sbjct: 596 RLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCI 655
Query: 659 HAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQG 718
AGCD +GSKK+FDKC VCGGD C K +G F K +GYN VV IPAGA+ I +RQ+G
Sbjct: 656 KAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQRG 715
Query: 719 NPG--HRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGP 776
G YLALK G Y LNG + + D+V+ G++ LRYSG A E+L P
Sbjct: 716 YKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSL-LRYSGTGTAVESLQASRP 774
Query: 777 LAQPLTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQD 816
+ +PLT++VL G R+RYSF++P+ P+D
Sbjct: 775 ILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKD 814
Score = 35.4 bits (80), Expect = 0.22
Identities = 18/52 (34%), Positives = 25/52 (48%), Gaps = 3/52 (5%)
Query: 527 GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEG--RRTRFRSCNTEDCPT 576
G WG CS +CG G+Q + DC + C+ R ++C E CPT
Sbjct: 846 GSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG-EPCPT 896
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 685 bits (1767), Expect = 0.0
Identities = 369/819 (45%), Positives = 498/819 (60%), Gaps = 75/819 (9%)
Query: 38 LLLLLASLLPSARLASPLP----REEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLL 93
LLLLL LLP AR A P + E+V P +L GS L L AFG+ +
Sbjct: 13 LLLLLLLLLPLARGAPARPAAGGQASELVVPTRLPGSA-------GELALHLSAFGKGFV 65
Query: 94 LELEQDSGVQVEGLTVQYLGQAPELLGGAEP--GTYLTGTINGDPESVASLHWDGGALLG 151
L L D ++ LG + GG G + +GT+NG+PES+A++ G L G
Sbjct: 66 LRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNGEPESLAAVSLCRG-LSG 124
Query: 152 VLQYRGAELHLQPLEGGTPNSAGGPGA--HILRRKSPASG----QGPMCNVKAPLG---- 201
G E +Q P AGG A H L+R PA +GP V+ G
Sbjct: 125 SFLLDGEEFTIQ------PQGAGGSLAQPHRLQRWGPAGARPLPRGPEWEVETGEGQRQE 178
Query: 202 --------------------SPSPRP----RRAKRFASLSRFVETLVVADDKMAAFHGAG 237
S P P R KRF S +RFVETL+VAD MAAF+GA
Sbjct: 179 RGDHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEARFVETLLVADASMAAFYGAD 238
Query: 238 LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQR 297
L+ ++LT+M+ AA+ +KHPSI+N ++L+V +++I+ + GP+V + TLR+FC WQR
Sbjct: 239 LQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQR 298
Query: 298 GLNTPEDSDPDHFDTAILFTRQDLCG-VSTCDTLGMADVGTVCDPARSCAIVEDDGLQSA 356
N P D P+H+DTAIL TRQ+ CG CDTLG+AD+GT+CDP +SC+++ED+GLQ+A
Sbjct: 299 RFNQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAA 358
Query: 357 FTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFL 416
T AHELGHV +M HD+SKPC L GP+ HVMAP+ H++ PWSPCSA ++T+ L
Sbjct: 359 HTLAHELGHVLSMPHDDSKPCTRLFGPMG-KHHVMAPLFVHLNQTLPWSPCSAMYLTELL 417
Query: 417 DNGYGHCLLDKPEAPLHLPVTFPGKD--YDADRQCQLTFGPDSRHCPQLPPP--CAALWC 472
D G+G CLLD P A L LP PG+ Y D+QC+ FGPD RHCP CA LWC
Sbjct: 418 DGGHGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWC 477
Query: 473 SGHLNG-HAMCQTKHS--PWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPW 529
H +G +C TK+ PWADGTPCGP C G CL ++++ GGW PWGPW
Sbjct: 478 --HTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPW 535
Query: 530 GDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAA 589
G+CSRTCGGGVQFS R+C P P+NGG+YC GRR +++SC+TE+CP +FRE+QC
Sbjct: 536 GECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPP-DGKSFREQQCEK 594
Query: 590 YN--HRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPD 647
YN + TD+ + + WVP+Y GV+P+D+CKL C+A+ + V E +V+DGT C P+
Sbjct: 595 YNAYNYTDMDGNL---LQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPE 651
Query: 648 SSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPA 707
+ ++CV+G+C+ AGCD ++ S +K DKC VCGG G+ C K SGS YGYN++VTIPA
Sbjct: 652 TLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVTIPA 711
Query: 708 GATHILVRQQGNPG--HRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGAT 765
GAT+I V+Q+ +PG + YLALK DG Y LNG + D+++ G + L+YSG+
Sbjct: 712 GATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTI-LKYSGSI 770
Query: 766 AASETLSGHGPLAQPLTLQVL-VAGNPQDTRLRYSFFVP 803
A E L PL +PLT+Q+L V G +++Y+FFVP
Sbjct: 771 ATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVP 809
Score = 30.4 bits (67), Expect = 7.1
Identities = 11/24 (45%), Positives = 14/24 (58%)
Query: 527 GPWGDCSRTCGGGVQFSSRDCTRP 550
G W +CS TCG G Q + +C P
Sbjct: 839 GDWSECSSTCGAGWQRRTVECRDP 862
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 580 bits (1495), Expect = e-165
Identities = 318/776 (40%), Positives = 435/776 (56%), Gaps = 61/776 (7%)
Query: 87 AFGETLLLELEQDSGVQVEGLTVQYLGQAPELLGGAEPGTYLTGTINGDPESVASLHWDG 146
A G LL+LE+D V + G G + + + GT++G P S+A G
Sbjct: 93 AGGRRFLLDLERDGSVGIAGFVPAGGGTSAPWRHRSH--CFYRGTVDGSPRSLAVFDLCG 150
Query: 147 GALLGVLQYRGAELHLQPLEGG-------------------------------------- 168
G L G + A L+PL G
Sbjct: 151 G-LDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASC 209
Query: 169 -TPNSAGGPGAHILRRKSPASGQGPMCN------VKAPLGSPSPRP--RRAKRFASLSRF 219
TP S H +P SG+ + + +P G P+ RR +R S +R
Sbjct: 210 ETPASTPEAHEHAPAHSNP-SGRAALASQLLDQSALSPAGGSGPQTWWRRRRRSISRARQ 268
Query: 220 VETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGP 279
VE L+VAD MA +G GL+ YLLT+ + A + + H SI N + L V ++V+LG ++
Sbjct: 269 VELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSL 328
Query: 280 QVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVC 339
+V +AA TL++FC WQ N D +H+D AILFTR+DLCG +CDTLGMADVGT+C
Sbjct: 329 EVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTIC 388
Query: 340 DPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVD 399
P RSCA++EDDGL +AFT AHE+GH+ + HD+SK C G R +M+ ++ +D
Sbjct: 389 SPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKR-LMSSILTSID 447
Query: 400 PEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRH 459
+PWS C++ IT+FLD+G+G+CLLD P + P PG+ YDA +QC LTFGP+
Sbjct: 448 ASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSV 507
Query: 460 CPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQ 519
CP + CA LWC+ G +C TK P +GTPCG + C+ G+C+ + + ++
Sbjct: 508 CPGM-DVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSS 566
Query: 520 AGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSA 579
G WG WG WG CSR+CGGGVQF+ R C P PRN G+YC G+R +RSC+ CP +
Sbjct: 567 HGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPP-NG 625
Query: 580 LTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVV 639
+FR EQC A N K ++WVP+Y GV P D CKLTC+A+ GYY V P+V
Sbjct: 626 KSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVT 685
Query: 640 DGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGY 699
DGT C S+SVCV+G+C+ GCD IIGSK ++DKC VCGGD S C+K G+F K GY
Sbjct: 686 DGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSKGY 745
Query: 700 NNVVTIPAGATHILVRQ--QGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAV 757
+VV IP GATHI VRQ + + YLALK +G Y +NG+Y + S T + + G V
Sbjct: 746 TDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTV 805
Query: 758 SLRYSGATAASETLSGHGPLA--QPLTLQVLVAGNPQDTRLRYSFFVPRPTPSTPR 811
+ YSG + + L G G A + L +Q+L + +RYSFFVP+ STP+
Sbjct: 806 -MNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPK--KSTPK 858
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif,
9 preproprotein [Homo sapiens]
Length = 1935
Score = 556 bits (1433), Expect = e-158
Identities = 274/601 (45%), Positives = 378/601 (62%), Gaps = 17/601 (2%)
Query: 208 RRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVT 267
RR KRF S RFVE LVVAD++M ++HG L+ Y+LT+M+ A +K PSI N +++V+
Sbjct: 283 RRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNLINIVIV 342
Query: 268 RLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGV-ST 326
L+++ + ++GP + +A TL++FC WQ N+P H DTA+L TRQD+C
Sbjct: 343 NLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGI---HHDTAVLLTRQDICRAHDK 399
Query: 327 CDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLST 386
CDTLG+A++GT+CDP RSC+I ED GL +AFT AHELGHVFNM HD++ C + +
Sbjct: 400 CDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEEG--VKS 457
Query: 387 SRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEA-PLHLPVTFPGKDYDA 445
+HVMAP + WS CS ++IT+FLD GYG CLL++PE+ P LPV PG Y+
Sbjct: 458 PQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGILYNV 517
Query: 446 DRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGR 505
++QC+L FGP S+ CP + C LWC+ H C+T+H+PWADGT C P + C G
Sbjct: 518 NKQCELIFGPGSQVCPYMMQ-CRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGF 576
Query: 506 CLHMDQLQDFNIPQA-GGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRT 564
C+ ++ ++P G WG W P+G CSRTCGGG++ + R+C RP P+NGGKYC GRR
Sbjct: 577 CVP----KEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRM 632
Query: 565 RFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQ 624
+F+SCNTE C FR+EQCA ++ + + WVP+Y+G+ +D+CKL C+
Sbjct: 633 KFKSCNTEPC-LKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCR 691
Query: 625 AQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSG 684
YY L RV+DGTPC D++ +CVQG C AGCD ++ SK + DKC VCGGD S
Sbjct: 692 VAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSS 751
Query: 685 CSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNPGHR--SIYLALKLPDGSYALNGEY 742
C +G+F YGYN VV IPAGAT+I VRQ G YLAL G + LNG +
Sbjct: 752 CKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNF 811
Query: 743 TLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFV 802
+ + ++ + AV + YSG+ A E ++ + Q L LQVL G + +RYSF +
Sbjct: 812 VVTMAKREIRIGNAV-VEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFNI 870
Query: 803 P 803
P
Sbjct: 871 P 871
Score = 40.4 bits (93), Expect = 0.007
Identities = 50/195 (25%), Positives = 73/195 (37%), Gaps = 44/195 (22%)
Query: 404 WSPCSA--------RFITDFLDNGY-----GHCLLDKPEAPLHLPVTFPGKDYDAD-RQC 449
W+PCSA R+++ +NG L +P A VT G+ D C
Sbjct: 1191 WTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQWKALDWSSC 1250
Query: 450 QLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADG----TPCGPAQACMGGR 505
+T G R Q+ + S H+ + C + P D +PC P + G
Sbjct: 1251 SVTCG-QGRATRQV----MCVNYSDHVIDRSECDQDYIPETDQDCSMSPC-PQRTPDSGL 1304
Query: 506 CLHMDQLQDFNIPQAG-------GWGPW--GPWGDCSRTCGGGVQ-----------FSSR 545
H Q +D+ A G W GPWG CS TC GG Q +++
Sbjct: 1305 AQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTAN 1364
Query: 546 DCTRPVPRNGGKYCE 560
DC + + + CE
Sbjct: 1365 DCVERIKPDEQRACE 1379
Score = 37.0 bits (84), Expect = 0.076
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 9/60 (15%)
Query: 526 WGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKY----CE--GRRTRFRSCNTEDCPTGSA 579
+G WG+C++ CGGG++ C R NG ++ CE + CNT CP +A
Sbjct: 1388 YGNWGECTKLCGGGIRTRLVVCQR---SNGERFPDLSCEILDKPPDREQCNTHACPHDAA 1444
Score = 35.0 bits (79), Expect = 0.29
Identities = 15/36 (41%), Positives = 18/36 (50%), Gaps = 1/36 (2%)
Query: 512 LQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDC 547
+Q P+ W GPWG CS TCG G Q + C
Sbjct: 1100 MQTCQQPECASWQA-GPWGQCSVTCGQGYQLRAVKC 1134
Score = 34.7 bits (78), Expect = 0.38
Identities = 36/150 (24%), Positives = 54/150 (36%), Gaps = 38/150 (25%)
Query: 456 DSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGG----------- 504
D C P P CSG N ++S W T C +++C GG
Sbjct: 976 DDGFCSSHPKPSNREKCSGECNTGGW---RYSAW---TEC--SKSCDGGTQRRRAICVNT 1027
Query: 505 --------RCLHMDQL-----QDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPV 551
+C H +++ +F PQ W G W +C TCG G + C
Sbjct: 1028 RNDVLDDSKCTHQEKVTIQRCSEFPCPQ---WKS-GDWSECLVTCGKGHKHRQVWCQFGE 1083
Query: 552 PRNGGKYC--EGRRTRFRSCNTEDCPTGSA 579
R + C E + T ++C +C + A
Sbjct: 1084 DRLNDRMCDPETKPTSMQTCQQPECASWQA 1113
Score = 33.9 bits (76), Expect = 0.64
Identities = 67/290 (23%), Positives = 91/290 (31%), Gaps = 77/290 (26%)
Query: 446 DRQCQ-LTFGPDSRHCPQLPPPCAALW-------CS-----GHLNGHAMCQTKHSPWADG 492
D C+ L PD C P A W CS GH + C K +
Sbjct: 1419 DLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLES 1478
Query: 493 TPCGPA------QACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRD 546
C + C GGRC P+ W G W CS +CG GVQ
Sbjct: 1479 DYCKHLAKPHGHRKCRGGRC-----------PK---WKA-GAWSQCSVSCGRGVQ----- 1518
Query: 547 CTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDW 606
R+ G C G+ RE +C Y R + + GP
Sbjct: 1519 -----QRHVG-----------------CQIGTHKIARETECNPYT-RPESERDCQGPR-- 1553
Query: 607 VPRYTGVAPQ-DQCKLTCQAQALGYYYVL----EPRVVDGTPCSPDSSSVCVQGRCIHAG 661
P YT A + +C TC + Y V+ V G C V + C
Sbjct: 1554 CPLYTWRAEEWQECTKTC-GEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRES-CSLQP 1611
Query: 662 CDRIIGSKKKFDKCMVCGGDG-----SGCSKQSGSFRKFRYGYNNVVTIP 706
C+ + ++ +C V G G CS+ + Y Y + P
Sbjct: 1612 CE-YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCP 1660
Score = 30.0 bits (66), Expect = 9.3
Identities = 15/40 (37%), Positives = 18/40 (45%), Gaps = 5/40 (12%)
Query: 504 GRCLHMDQLQDFNIP-----QAGGWGPWGPWGDCSRTCGG 538
G+ + D FNIP Q W GPW CS+ C G
Sbjct: 857 GKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQG 896
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 547 bits (1410), Expect = e-155
Identities = 308/810 (38%), Positives = 432/810 (53%), Gaps = 76/810 (9%)
Query: 60 EIVFPEKLN--GSVLPGSG--------------APARLLCRLQAFGETLLLELEQDSGVQ 103
E+V PE++N G V P S P R R A+G+ L L D+
Sbjct: 41 EVVIPERVNEFGEVFPQSHHFSRQKRSSEALEPMPFRTHYRFTAYGQLFQLNLTADASFL 100
Query: 104 VEGLTVQYLGQAPELLGGAEPGT------YLTGTINGDPESVASLHWDGGALLGVLQYRG 157
G T +LG ++ G + G +N + A + GG L G + +
Sbjct: 101 AAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQEDYKAVVSLCGG-LTGTFKGQN 159
Query: 158 AELHLQPL--EGGTPNSAGGPGAHILRRKS---------------------------PAS 188
E L+P+ G G H++ R+ S
Sbjct: 160 GEYFLEPIMKADGNEYEDGHNKPHLIYRQDLNNSFLQTLKYCSVSESQIKETSLPFHTYS 219
Query: 189 GQGPMCNV--KAPLGSPSP--------RPRRAKRFASLSRFVETLVVADDKMAAFHGAGL 238
NV + LG S R R KR S R++E +V AD K+ + HG+ L
Sbjct: 220 NMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLISYPRYIEIMVTADAKVVSAHGSNL 279
Query: 239 KRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRG 298
+ Y+LT+M+ A +K PSI N + +VV +LV++ EEGP + A TL++FC+WQ+
Sbjct: 280 QNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQT 339
Query: 299 LNTPEDSDPDHFDTAILFTRQDLCGVST-CDTLGMADVGTVCDPARSCAIVEDDGLQSAF 357
N +D P H DTA+L TR+D+C C+ LG++ +GT+CDP +SC I E+ GL SAF
Sbjct: 340 QNDLDDVHPSHHDTAVLITREDICSSKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAF 399
Query: 358 TAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMA-HVDPEEPWSPCSARFITDFL 416
T AHELGH + HD++ C + T HVMAP ++ H+ P WS CS +++T+FL
Sbjct: 400 TIAHELGHTLGVQHDDNPRCKEMK---VTKYHVMAPALSFHMSPWS-WSNCSRKYVTEFL 455
Query: 417 DNGYGHCLLDKPEAPLH-LPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGH 475
D GYG CLLDKP+ ++ LP PG YD ++QC+L FGP S+ CP + C LWC+
Sbjct: 456 DTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQMCPHINI-CMHLWCTST 514
Query: 476 LNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRT 535
H C T+H P ADGT CGP C G C++ + P G WGPW P+ CSRT
Sbjct: 515 EKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKETETR---PVNGEWGPWEPYSSCSRT 571
Query: 536 CGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTD 595
CGGG++ ++R C RP PRNGG YC GRR +FRSCNT+ CP G+ FRE+QC+ +N +
Sbjct: 572 CGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQ-DFREKQCSDFNGKHL 630
Query: 596 LFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQG 655
P + W+PRY+G+ +D+CKL CQ Y+Y+L+ V DGTPC ++ +CVQG
Sbjct: 631 DISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQG 690
Query: 656 RCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVR 715
+C+ AGCD ++ S K DKC VCGGD S C +G F YGYN VV IPAGAT++ +R
Sbjct: 691 QCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSHYGYNVVVKIPAGATNVDIR 750
Query: 716 QQGNPGH-RSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGA-VSLRYSGATAASETLSG 773
Q G YLAL +G++ NG + L S ++ + G + YSG+ A E ++
Sbjct: 751 QYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNNAVERINS 810
Query: 774 HGPLAQPLTLQVLVAGNPQDTRLRYSFFVP 803
+ L LQVL GN + + YSF +P
Sbjct: 811 TNRQEKELILQVLCVGNLYNPDVHYSFNIP 840
Score = 35.8 bits (81), Expect = 0.17
Identities = 18/53 (33%), Positives = 24/53 (45%), Gaps = 7/53 (13%)
Query: 527 GPWGDCSRTCGGGVQFSSRDCTRPVPRNG--GKYCE--GRRTRFRSCNTEDCP 575
GPWG CS +C GG+Q + C NG YC+ + + C CP
Sbjct: 1311 GPWGSCSSSCSGGLQHRAVVCQ---DENGQSASYCDAASKPPELQQCGPGPCP 1360
Score = 35.8 bits (81), Expect = 0.17
Identities = 28/84 (33%), Positives = 38/84 (45%), Gaps = 20/84 (23%)
Query: 472 CSGHLNGHAM-CQTKH---SPWADGTPCGPA-QACMGGRCLHMDQLQDFNIPQAGGWGPW 526
CSG L A+ CQ ++ + + D P Q C G C PQ W +
Sbjct: 1320 CSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPC-----------PQ---WN-Y 1364
Query: 527 GPWGDCSRTCGGGVQFSSRDCTRP 550
G WG+CS+TCGGG++ C P
Sbjct: 1365 GNWGECSQTCGGGIKSRLVICQFP 1388
Score = 32.3 bits (72), Expect = 1.9
Identities = 19/61 (31%), Positives = 26/61 (42%), Gaps = 2/61 (3%)
Query: 526 WGPWGDCSRTCGGGVQFSSRDCTRPV-PRNGGKYC-EGRRTRFRSCNTEDCPTGSALTFR 583
+ W CSR+CGGG + C R C E R +CN CP+ +A +
Sbjct: 972 YSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCPSWAASEWS 1031
Query: 584 E 584
E
Sbjct: 1032 E 1032
Score = 31.6 bits (70), Expect = 3.2
Identities = 11/21 (52%), Positives = 12/21 (57%)
Query: 527 GPWGDCSRTCGGGVQFSSRDC 547
GPWG C+ TCG G Q C
Sbjct: 1083 GPWGPCTTTCGHGYQMRDVKC 1103
Score = 30.8 bits (68), Expect = 5.4
Identities = 14/40 (35%), Positives = 18/40 (45%), Gaps = 5/40 (12%)
Query: 504 GRCLHMDQLQDFNIP-----QAGGWGPWGPWGDCSRTCGG 538
G + D FNIP W P+GPW C++ C G
Sbjct: 826 GNLYNPDVHYSFNIPLEERSDMFTWDPYGPWEGCTKMCQG 865
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif,
6 preproprotein [Homo sapiens]
Length = 1117
Score = 426 bits (1094), Expect = e-119
Identities = 280/773 (36%), Positives = 387/773 (50%), Gaps = 70/773 (9%)
Query: 77 APARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQ-APELLGGAEPGTYLTGTINGD 135
A ++L +L A+G+ L L ++ + TV+Y G+ P+ + TG +
Sbjct: 81 AVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLDNCHYTGYLQDQ 140
Query: 136 PESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSA------GGPGAHILRRKSPA-- 187
+ + L GV+ E ++PL+ T +S G P H++ +KS
Sbjct: 141 RSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHP--HVIYKKSALQQ 198
Query: 188 ----------------SGQGPMCNVKAPLGSPSPRPR-----RAKRFASLSRFVETLVVA 226
SG+ N + + P R KR S+ RFVETLVVA
Sbjct: 199 RHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFVETLVVA 258
Query: 227 DDKMAAFHGA-GLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSA 285
D M +HG ++ Y+L+VM AK ++ S+ N V+++V RL++L + ++ A
Sbjct: 259 DKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHA 318
Query: 286 AQTLRSFCAWQRGL-------NTPEDSDPDHFDTAILFTRQDLCGVST--CDTLGMADVG 336
++L SFC WQ+ + NT ++ H D A+L TR D+C C TLG+A V
Sbjct: 319 DKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVA 378
Query: 337 TVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMA 396
+C+P RSC+I ED GL SAFT AHE+GH F M HD G ++ + A + A
Sbjct: 379 GMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGH-EAAKLMAAHITA 437
Query: 397 HVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHL-PVTFPGKDYDADRQCQLTFGP 455
+ +P WS CS +IT FLD+G G CL ++P L P PG+ YDAD QC+ +G
Sbjct: 438 NTNPFS-WSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGA 496
Query: 456 DSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDF 515
SR C + C LWC N C T P A+GT C G C D +
Sbjct: 497 TSRQC-KYGEVCRELWCLSKSN---RCVTNSIPAAEGTLCQTGNIEKGW-CYQGDCVPFG 551
Query: 516 NIPQA--GGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTED 573
PQ+ GGWGPW WG+CSRTCGGGV S R C P P GGKYC G R R+RSCNT+
Sbjct: 552 TWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDP 611
Query: 574 CPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYV 633
CP GS FRE+QCA +++ K + +W P YTG + C L C A+ +Y
Sbjct: 612 CPLGSR-DFREKQCADFDNMPFRGKYY----NWKP-YTGGGVK-PCALNCLAEGYNFYTE 664
Query: 634 LEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFR 693
P V+DGT C+ DS +C+ G C H GCD I+GS + D+C VCGGDGS C G F
Sbjct: 665 RAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFN 724
Query: 694 KF--RYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTL-MPSPTD 750
R GY VV IP G+ HI VR+ + Y+ALK Y +NG +T+ P D
Sbjct: 725 DSLPRGGYMEVVQIPRGSVHIEVREVAMSKN---YIALKSEGDDYYINGAWTIDWPRKFD 781
Query: 751 VVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVP 803
V + Y T E+L GP ++ L + VL+ Q+ +RY F VP
Sbjct: 782 V---AGTAFHYKRPTDEPESLEALGPTSENLIVMVLL--QEQNLGIRYKFNVP 829
Score = 39.7 bits (91), Expect = 0.012
Identities = 21/53 (39%), Positives = 25/53 (47%), Gaps = 5/53 (9%)
Query: 528 PWGDCSRTCGGGVQFSSRDCTRPVPRN--GGKYCEGRR---TRFRSCNTEDCP 575
PW +CS TC GGVQ C R + YC+ R+CNTE CP
Sbjct: 848 PWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP 900
Score = 33.1 bits (74), Expect = 1.1
Identities = 26/91 (28%), Positives = 41/91 (45%), Gaps = 16/91 (17%)
Query: 527 GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCE------GRRTRFRSCNTEDC-PTGSA 579
G W +CS+TC GG++ + C R + + + + R CN + C P A
Sbjct: 906 GDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVA 965
Query: 580 LTFRE--EQCA-AYNHR------TDLFKSFP 601
L + E +C + HR +DL K+FP
Sbjct: 966 LDWSECTPKCGPGFKHRIVLCKSSDLSKTFP 996
Score = 33.1 bits (74), Expect = 1.1
Identities = 19/59 (32%), Positives = 23/59 (38%), Gaps = 11/59 (18%)
Query: 527 GPWGDCSRTCGGGVQF-----------SSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDC 574
G WG CS CG G Q +S DC V + CE + NTE+C
Sbjct: 1025 GDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEEC 1083
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 399 bits (1025), Expect = e-111
Identities = 286/816 (35%), Positives = 390/816 (47%), Gaps = 84/816 (10%)
Query: 60 EIVFPEKL--NGSVLP-------------GSGAPARLLCRLQAFGETLLLELEQDSGVQV 104
EI FP ++ NG++L G+ A +RL ++ + LL L + S +
Sbjct: 40 EIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLA 99
Query: 105 EGLTVQY-LGQAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQ 163
++V+Y + A P G + G + G L G++ E ++
Sbjct: 100 GHVSVEYWTREGLAWQRAARPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIE 159
Query: 164 PLEGGTPNSAGGP---GAHILRRKSPASGQ--GPMCNVK--------------------A 198
PL GG P + P G H++ ++S C V+
Sbjct: 160 PLHGG-PKGSRSPEESGPHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPAR 218
Query: 199 PLGSPSPRPRRA-KRFASLSRFVETLVVADDKMAAFHGA-GLKRYLLTVMAAAAKAFKHP 256
PLG+ + R + KR S R+VETLVVAD M A+HG +++Y+L +M AK F+
Sbjct: 219 PLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDS 278
Query: 257 SIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQR--------GLNTPEDSDPD 308
S+ + V+++VTRL++L + ++ A ++L SFC WQ+ G PE+ +
Sbjct: 279 SLGSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVAN 338
Query: 309 HFDTAILFTRQDLCGVST--CDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHV 366
H DTA+L TR D+C C TLG+A VG +C+ RSC++ ED GL +AFT AHE+GH
Sbjct: 339 H-DTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHT 397
Query: 367 FNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLD 426
F M HD G ++ + A + +P WS CS +IT FLD+G G CL +
Sbjct: 398 FGMNHDGVGNSCGARGQ-DPAKLMAAHITMKTNPFV-WSSCSRDYITSFLDSGLGLCLNN 455
Query: 427 KP-EAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTK 485
+P P PG+ YDAD QC+ G SR C + C+ LWC N C T
Sbjct: 456 RPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQC-KYGEVCSELWCLSKSN---RCITN 511
Query: 486 HSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQA--GGWGPWGPWGDCSRTCGGGVQFS 543
P A+GT C G C + + P+ G WGPW PWGDCSRTCGGGV S
Sbjct: 512 SIPAAEGTLC-QTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSS 570
Query: 544 SRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGP 603
SR C P P GGKYC G R R RSCNT+DCP GS FRE QC+ ++ F G
Sbjct: 571 SRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQ-DFREVQCSEFDS-----IPFRGK 624
Query: 604 MDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCD 663
Y G + C LTC A+ +Y VVDGTPC PD+ +CV G C H GCD
Sbjct: 625 FYKWKTYRGGGVK-ACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCD 683
Query: 664 RIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFR--YGYNNVVTIPAGATHILVRQQGNPG 721
R++GS + DKC VCGGDGS C G F GY +VV IP G+ HI ++ +
Sbjct: 684 RVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQ---DLN 740
Query: 722 HRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPL 781
+LALK S L G P P + L G G ++L GP+
Sbjct: 741 LSLSHLALKGDQESLLLEG-LPGTPQPHRLPLAGTTFQLRQGPDQV-QSLEALGPI--NA 796
Query: 782 TLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDW 817
+L V+V + LRY F P S P P W
Sbjct: 797 SLIVMVLARTELPALRYRFNAPIARDSLP---PYSW 829
Score = 39.3 bits (90), Expect = 0.015
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 5/55 (9%)
Query: 526 WGPWGDCSRTCGGGVQFSSRDCTRPVPRN--GGKYCEGRR---TRFRSCNTEDCP 575
+ PW CS C GG Q + +C + + YC R R+CNTE CP
Sbjct: 831 YAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCP 885
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 380 bits (976), Expect = e-105
Identities = 236/656 (35%), Positives = 339/656 (51%), Gaps = 54/656 (8%)
Query: 117 ELLGGAEPGTYLTGTI--NGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAG 174
+++ + P +L+GT+ G A+L G L G Q + ++P++ P G
Sbjct: 130 KMMASSAPLCHLSGTVLQQGTRVGTAALSACHG-LTGFFQLPHGDFFIEPVKKH-PLVEG 187
Query: 175 GPGAHIL-RRKSPASGQGPMCNVKAPLGSPS--------------PRPRRAKRFASLSRF 219
G HI+ RR+ + P C +K + P ++R S R+
Sbjct: 188 GYHPHIVYRRQKVPETKEPTCGLKDSVNISQKQELWREKWERHNLPSRSLSRRSISKERW 247
Query: 220 VETLVVADDKMAAFHGA-GLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEG 278
VETLVVAD KM +HG+ ++ Y+LT+M F +PSI N + +VV RL++L E+G
Sbjct: 248 VETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQG 307
Query: 279 PQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVST--CDTLGMADVG 336
++ A +TL SFC WQ+ +N D +P H D A+L TR+D+C C+TLG++ +
Sbjct: 308 LKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLS 367
Query: 337 TVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMA 396
+C P RSC I ED GL AFT AHELGH F + HD + P+ ++M+ +
Sbjct: 368 GMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCE---PVGRHPYIMSRQLQ 424
Query: 397 HVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAP-LHLPVTFPGKDYDADRQCQLTFGP 455
+ WS CS +IT FLD G+G CL D P+ L V PG YD QCQL +GP
Sbjct: 425 YDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGP 484
Query: 456 DSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDF 515
++ C ++ C LWCS C++K ADGT CG + CM G+C+ + + +
Sbjct: 485 NATFCQEVENVCQTLWCSVK----GFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPE- 539
Query: 516 NIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCP 575
+IP GGWG W PW CSRTCG GVQ + R C P P+ GGKYC G R R+R CN C
Sbjct: 540 SIP--GGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPC- 596
Query: 576 TGSALTFREEQCAAYN---HRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYY 632
A TFR+ QC+ ++ ++ +L+ W P + P C+L C+ +
Sbjct: 597 RSEAPTFRQMQCSEFDTVPYKNELY-------HWFPIFN---PAHPCELYCRPIDGQFSE 646
Query: 633 VLEPRVVDGTPC--SPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSG 690
+ V+DGTPC +S +VC+ G C GCD I S D+C VC GDGS C
Sbjct: 647 KMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRK 706
Query: 691 SFR-KFRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPD-GSYALNGEYTL 744
F+ K GY ++ IP GA I V + G+ +LA++ D Y LNG + +
Sbjct: 707 MFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGN---FLAIRSEDPEKYYLNGGFII 759
Score = 35.0 bits (79), Expect = 0.29
Identities = 20/49 (40%), Positives = 22/49 (44%), Gaps = 9/49 (18%)
Query: 528 PWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCE--GRRTRFRSCNTEDC 574
PW CSR+CGGGVQ C G C+ R T SCN C
Sbjct: 1431 PWSQCSRSCGGGVQERGVFCP-------GGLCDWTKRPTSTMSCNEHLC 1472
Score = 35.0 bits (79), Expect = 0.29
Identities = 22/72 (30%), Positives = 32/72 (44%), Gaps = 12/72 (16%)
Query: 527 GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGK-------YCE--GRRTRFRSCNTEDCPTG 577
G W CS +CGGG Q + C VP G K C+ R F+ CN + C
Sbjct: 1478 GNWDLCSTSCGGGFQKRTVQC---VPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKS 1534
Query: 578 SALTFREEQCAA 589
+ L +++ +A
Sbjct: 1535 ADLLCTKDKLSA 1546
Score = 34.7 bits (78), Expect = 0.38
Identities = 18/52 (34%), Positives = 28/52 (53%), Gaps = 6/52 (11%)
Query: 527 GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCE-GRRTRFRS-CNTEDCPT 576
G W +CS +CGGGV+ S C +N + C+ R+ R+ C + CP+
Sbjct: 951 GNWSECSVSCGGGVRIRSVTCA----KNHDEPCDVTRKPNSRALCGLQQCPS 998
Score = 30.8 bits (68), Expect = 5.4
Identities = 19/75 (25%), Positives = 32/75 (42%), Gaps = 11/75 (14%)
Query: 514 DFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGR-RTRFRSCNTE 572
D ++ Q + +G W +CS TCG G++ + C + +GR + C+ E
Sbjct: 818 DNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIK----------KGRGMVKATFCDPE 867
Query: 573 DCPTGSALTFREEQC 587
P G E+ C
Sbjct: 868 TQPNGRQKKCHEKAC 882
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif,
7 preproprotein [Homo sapiens]
Length = 1686
Score = 376 bits (965), Expect = e-104
Identities = 283/812 (34%), Positives = 387/812 (47%), Gaps = 97/812 (11%)
Query: 38 LLLLLASLLPSARLASPLPREE-----EIVFPEKLN--GSVLPGSGAPARLLCR------ 84
LLLLL +L P A +P E +IV P +++ GS L P L R
Sbjct: 17 LLLLLCALAPGAPGPAPGRATEGRAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSVRR 76
Query: 85 -------LQAFGETLLLELEQDSGVQVEGLTVQY-----LGQAPELLGGAEPGTYLTGTI 132
LQ G L L + + G + LG+A + P +L G +
Sbjct: 77 DAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAH--IRAHTPACHLLGEV 134
Query: 133 NGDPESVASLH----WDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHIL-RRKSPA 187
DPE L DG L GV Q + ++PL+ P G H++ +R++P
Sbjct: 135 Q-DPELEGGLAAISACDG--LKGVFQLSNEDYFIEPLDSA-PARPGHAQPHVVYKRQAPE 190
Query: 188 -------SGQGPMCNVKAPLGSPS-------------PRPRRA-KRFASLSRFVETLVVA 226
S C V+ S PR RR +R S ++VETLVVA
Sbjct: 191 RLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRLRRLHQRSVSKEKWVETLVVA 250
Query: 227 DDKMAAFHGAG-LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSA 285
D KM +HG ++ Y+LT+M A F PSI NP+ + + RLV+L EE ++ A
Sbjct: 251 DAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHA 310
Query: 286 AQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVST--CDTLGMADVGTVCDPAR 343
TL+SFC WQ+ +N D+ P H DTAIL TR+DLC C+TLG++ V +C P R
Sbjct: 311 DNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHR 370
Query: 344 SCAIVEDDGLQSAFTAAHELGHVFNMLHDNS-KPCISLNGPLSTSRHVMAPVMAHVDPEE 402
SC+I ED GL AFT AHELGH F + HD S C P+ +M+P + +
Sbjct: 371 SCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDC----EPVGKRPFIMSPQLLYDAAPL 426
Query: 403 PWSPCSARFITDFLDNGYGHCLLDKPEAP-LHLPVTFPGKDYDADRQCQLTFGPDSRHCP 461
WS CS ++IT FLD G+G CL D P + P PG YD QC+L +G S C
Sbjct: 427 TWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCE 486
Query: 462 QLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQA- 520
+ C LWCS C +K DGT CG + C+ G C+ + P+A
Sbjct: 487 DMDNVCHTLWCS----VGTTCHSKLDAAVDGTRCGENKWCLSGECVPVGFR-----PEAV 537
Query: 521 -GGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSA 579
GGW W W CSR+CG GVQ + R CT+P P+ G+YC G R RFR CN + CP G
Sbjct: 538 DGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRP 597
Query: 580 LTFREEQCAAYNHRTDLFKSFPGPM-DWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRV 638
+FR QC+ ++ + G + WVP V P C+L C+ + L V
Sbjct: 598 -SFRHVQCSHFDAML-----YKGQLHTWVPVVNDVNP---CELHCRPANEYFAEKLRDAV 648
Query: 639 VDGTPCSP--DSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFR 696
VDGTPC S +C+ G C + GCD I S D+C VC G+GS C SG+F +
Sbjct: 649 VDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAE 708
Query: 697 -YGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPD-GSYALNGEYTLMPSPTDVVLP 754
GY +V IPAGA I +++ + +LAL+ D Y LNG +T+ + V
Sbjct: 709 GLGYVDVGLIPAGAREIRIQEVAEAAN---FLALRSEDPEKYFLNGGWTIQWNGDYQVAG 765
Query: 755 GAVSLRYSGATAASETLSGHGPLAQPLTLQVL 786
+ G E L+ GP +P+ +Q+L
Sbjct: 766 TTFTYARRGNW---ENLTSPGPTKEPVWIQLL 794
Score = 41.2 bits (95), Expect = 0.004
Identities = 22/53 (41%), Positives = 23/53 (43%), Gaps = 5/53 (9%)
Query: 527 GPWGDCSRTCGGGVQFSSRDCTRP---VPRNGGKYC--EGRRTRFRSCNTEDC 574
GPWG CS CGGGVQ C +P C E R C TEDC
Sbjct: 1576 GPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 32.3 bits (72), Expect = 1.9
Identities = 20/57 (35%), Positives = 30/57 (52%), Gaps = 10/57 (17%)
Query: 526 WGPWGDCSRTCGGGVQFSSRDCTRPVPRNGG----KYCE--GR-RTRFRSCNTEDCP 575
+GPW C+ TCG GVQ + C + R G ++C+ GR + R C+ + CP
Sbjct: 827 YGPWTKCTVTCGRGVQRQNVYC---LERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880
Score = 31.6 bits (70), Expect = 3.2
Identities = 18/48 (37%), Positives = 19/48 (39%), Gaps = 8/48 (16%)
Query: 529 WGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEG--RRTRFRSCNTEDC 574
W +CS CGGG Q C P CE R R CNT C
Sbjct: 1529 WRECSEACGGGEQQRLVTCPEP------GLCEEALRPNTTRPCNTHPC 1570
Score = 30.8 bits (68), Expect = 5.4
Identities = 18/63 (28%), Positives = 27/63 (42%), Gaps = 5/63 (7%)
Query: 527 GPWGDCSRTCGGGVQFSSRDC--TRPVPRNGGKYCE---GRRTRFRSCNTEDCPTGSALT 581
G W CSR+CGGG C TR + +C+ + R C + C + +
Sbjct: 1469 GNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLSWYTSS 1528
Query: 582 FRE 584
+RE
Sbjct: 1529 WRE 1531
Score = 30.0 bits (66), Expect = 9.3
Identities = 29/101 (28%), Positives = 37/101 (36%), Gaps = 26/101 (25%)
Query: 522 GWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCE----GRRTRFRSCNTEDCPT- 576
GW G W +CS TCG G + RPV + G+ + GR R C+ C T
Sbjct: 1414 GWQA-GNWSECSTTCGLGAVW------RPVRCSSGRDEDCAPAGRPQPARRCHLRPCATW 1466
Query: 577 ------------GSALTFREEQCAAYNHRTDL--FKSFPGP 603
G + R+ QC L F PGP
Sbjct: 1467 HSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGP 1507
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 361 bits (926), Expect = 2e-99
Identities = 228/621 (36%), Positives = 312/621 (50%), Gaps = 39/621 (6%)
Query: 204 SPRPRRAKRFASLSRFVETLVVADDKMAAFHGAG-LKRYLLTVMAAAAKAFKHPSIRNPV 262
S RPRR+ + VETLVVAD KM HG G + Y+LTVM + FK +I + +
Sbjct: 279 SGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDI 338
Query: 263 SLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLC 322
++VV L++L G + A Q+L SFC WQ L DH AIL T D+C
Sbjct: 339 NVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDH---AILLTGFDIC 395
Query: 323 GVST--CDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNS-KPCIS 379
CDTLG A + +C RSC I ED GL AFT AHE GH F M+HD PC
Sbjct: 396 SWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRK 455
Query: 380 LNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPE--APLHLPVT 437
G ++M+P + + WS CS +++ FL CL+D+P+ P
Sbjct: 456 AEG------NIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDK 509
Query: 438 FPGKDYDADRQCQLTFGPDSRHCPQ--LPPPCAALWCSGHLNGHAMCQTKHSPWADGTPC 495
PG+ YDAD QC+ FG ++ C + C +LWC H GH C+TK P A+GT C
Sbjct: 510 LPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWC--HRVGHR-CETKFMPAAEGTVC 566
Query: 496 GPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNG 555
G + C G+C+ +L P G W W W +CSRTCGGGV+F R C P P+ G
Sbjct: 567 GLSMWCRQGQCVKFGELGPR--PIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYG 624
Query: 556 GKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPM-DWVPRYTGVA 614
G +C G ++ CN C S L FR +QCA YN K F G W P YT V
Sbjct: 625 GLFCPGSSRIYQLCNINPCNENS-LDFRAQQCAEYNS-----KPFRGWFYQWKP-YTKVE 677
Query: 615 PQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDK 674
+D+CKL C+A+ +++ + +V DGTPCSP+ + VC+ G C GCD +GSK D
Sbjct: 678 EEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDA 737
Query: 675 CMVCGGDGSGCSKQSGSFRKFRYG--YNNVVTIPAGATHILVRQQGNPGHRSIYLALKLP 732
C VC GD S C G + Y VV IPAGA I +++ S YLA++
Sbjct: 738 CGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQEL---QVSSSYLAVRSL 794
Query: 733 DGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQ 792
Y L G +++ P + G + Y + E L GP + L ++L+ G +
Sbjct: 795 SQKYYLTGGWSI-DWPGEFPFAG-TTFEYQRSFNRPERLYAPGPTNETLVFEILMQG--K 850
Query: 793 DTRLRYSFFVPRPTPSTPRPT 813
+ + + + +P+ TP T
Sbjct: 851 NPGIAWKYALPKVMNGTPPAT 871
Score = 40.0 bits (92), Expect = 0.009
Identities = 18/48 (37%), Positives = 23/48 (47%)
Query: 528 PWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCP 575
PW C+ TCGGGVQ S C + + + R+CNT CP
Sbjct: 1131 PWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCP 1178
Score = 32.3 bits (72), Expect = 1.9
Identities = 18/59 (30%), Positives = 25/59 (42%), Gaps = 7/59 (11%)
Query: 523 WGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGK-----YCE-GRRTRFRSCNTEDCP 575
W P G W CS+ C GG Q C + P + C T+ ++CN+ CP
Sbjct: 935 WMP-GEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACP 992
Score = 30.8 bits (68), Expect = 5.4
Identities = 10/15 (66%), Positives = 12/15 (80%)
Query: 527 GPWGDCSRTCGGGVQ 541
GPW CS+TCG GV+
Sbjct: 998 GPWSQCSKTCGRGVR 1012
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1
motif, 16 preproprotein [Homo sapiens]
Length = 1224
Score = 352 bits (902), Expect = 1e-96
Identities = 219/596 (36%), Positives = 297/596 (49%), Gaps = 47/596 (7%)
Query: 220 VETLVVADDKMAAFHG-AGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEG 278
VETLVV D KM HG + Y+LT++ + FK +I +++ + L++L + G
Sbjct: 292 VETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPG 351
Query: 279 PQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVST--CDTLGMADVG 336
+ A TL SFC WQ GL + + DH AIL T D+C CDTLG A +
Sbjct: 352 LVISHHADHTLSSFCQWQSGLMGKDGTRHDH---AILLTGLDICSWKNEPCDTLGFAPIS 408
Query: 337 TVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMA 396
+C RSC I ED GL AFT AHE GH F M+HD N + ++M+P +A
Sbjct: 409 GMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEG-----NMCKKSEGNIMSPTLA 463
Query: 397 HVDPEEPWSPCSARFITDFLDNGYGHCLLD--KPEAPLHLPVTFPGKDYDADRQCQLTFG 454
+ WSPCS +++ FL CL D KP P PG+ YDA+ QC+ FG
Sbjct: 464 GRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFG 523
Query: 455 PDSRHCPQ--LPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQL 512
++ C C ALWC H G C+TK P A+GT CG C GG+C+
Sbjct: 524 EKAKLCMLDFKKDICKALWC--HRIGRK-CETKFMPAAEGTICGHDMWCRGGQCVKYGD- 579
Query: 513 QDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTE 572
+ P G W W W CSRTCGGGV SR CT P P +GGK+CEG + CN++
Sbjct: 580 -EGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQ 638
Query: 573 DCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYY 632
CP S + FR QCA +N R + + W P YT V QD CKL C A+ +++
Sbjct: 639 KCPRDS-VDFRAAQCAEHNSRRFRGRHYK----WKP-YTQVEDQDLCKLYCIAEGFDFFF 692
Query: 633 VLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSF 692
L +V DGTPCS DS +VC+ G C GCD ++GS D C VC G+ S C+ G +
Sbjct: 693 SLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLY 752
Query: 693 RKFRY--GYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTD 750
K + Y ++VTIP+GA I + + + Y++++ Y LNG +T
Sbjct: 753 TKHHHTNQYYHMVTIPSGARSIRIYEM---NVSTSYISVRNALRRYYLNGHWT------- 802
Query: 751 VVLPGAVSLRYSGAT-------AASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYS 799
V PG ++SG T E L GP + L +++L G YS
Sbjct: 803 VDWPG--RYKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYS 856
Score = 41.6 bits (96), Expect = 0.003
Identities = 23/75 (30%), Positives = 30/75 (40%), Gaps = 4/75 (5%)
Query: 518 PQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTG 577
P G W PW C+ +CGGGVQ S C G + + +CNT CP
Sbjct: 1125 PSRGSWFA-SPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPIA 1183
Query: 578 SALTFREEQCAAYNH 592
++ C Y H
Sbjct: 1184 EK---KDAFCKDYFH 1195
Score = 40.0 bits (92), Expect = 0.009
Identities = 22/57 (38%), Positives = 28/57 (49%), Gaps = 11/57 (19%)
Query: 527 GPWGDCSRTCGGGVQFSSRDCTR-------PVPRNGGKYC-EGRRTRFRSCNTEDCP 575
G W CSRTCGGG Q CTR PVP C + + ++CN++ CP
Sbjct: 934 GNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVP---ASLCPQPAPSSRQACNSQSCP 987
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
Length = 1095
Score = 338 bits (866), Expect = 2e-92
Identities = 274/869 (31%), Positives = 377/869 (43%), Gaps = 141/869 (16%)
Query: 22 PCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEEI----VFPEKLNGSVLPGSGA 77
P L+LP+ LLLL+ L P + E + V P+ ++ LP +
Sbjct: 8 PPLVLPV---------LLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPG 58
Query: 78 PAR-------------------LLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPEL 118
P R LL L AFG L L+L +D G V+ G A
Sbjct: 59 PRRRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRR 118
Query: 119 LGGAEPGTYLTGTINGDPESVASLHWDG--GALLGVLQYRGAELHLQPLEGGTPNSAGGP 176
AE Y +G + G P S+ SL G G L+G++Q ++ +QPL N++ GP
Sbjct: 119 GRPAELCFY-SGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPL-----NNSQGP 172
Query: 177 GA---HILRRK-----SP-ASGQGP--MCNV-----KAPLGSPSP--RPRRAKRFASLSR 218
+ H++RRK SP A Q P +C V K G PS R RR +
Sbjct: 173 FSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEH 232
Query: 219 FVETLVVADDKMAAFHGA-GLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEE 277
VETLVVAD M +HGA +R++LTVM F+H S+ +++ VT+LV+L
Sbjct: 233 TVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPA 292
Query: 278 GPQVGPSAAQTLRSFCAWQ-------RGLNTPE----DSDPDHFDTAILFTRQDLC--GV 324
+G ++L SFC WQ R L + DP D A+ TR D C
Sbjct: 293 KLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKD 352
Query: 325 STCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPL 384
CDT+G+A +G VC R C + ED+GL AFT AHELGH M HD+ +
Sbjct: 353 EPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDD------HSSC 406
Query: 385 STSRHVMAP--VMAHVDPEEPWSPCSARFITDFLDNGYGHCLL---DKPEAPLHLPVTFP 439
+ H+M+ V + WS CS + +FL + CLL + + + LP P
Sbjct: 407 AGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLP 466
Query: 440 GKDYDADRQCQLTFGPDSRHCPQLPP-PCAALWCSGHLNGHAMCQTKHSPWADGTPCGPA 498
G Y A+ QCQ+ FG ++ C + CA LWC + G C+TK P DGT CG
Sbjct: 467 GMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCL--VEGDTSCKTKLDPPLDGTECGAD 524
Query: 499 QACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKY 558
+ C G C+ + + G W PWG W CSRTCG G +F R C P P GG +
Sbjct: 525 KWCRAGECVSKTPIPEH---VDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTH 581
Query: 559 CEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQ 618
C G C CP G +FR++QC A++ + K T V D+
Sbjct: 582 CPGASVEHAVCENLPCPKGLP-SFRDQQCQAHDRLSPKKKGL---------LTAVVVDDK 631
Query: 619 -CKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMV 677
C+L C ++ RV+DGTPC P + +CV G+C GCD IIGS K D+C V
Sbjct: 632 PCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGV 691
Query: 678 CGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYA 737
C GDG C G F + A ++ G S D
Sbjct: 692 CSGDGKTCHLVKGDF--------------SHARGTALKDSGKGSINS--------DWKIE 729
Query: 738 LNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLR 797
L GE+ + + V G E +S GP PL L VL+ + QD +
Sbjct: 730 LPGEFQIAGTTVRYVRRG-----------LWEKISAKGPTKLPLHLMVLLF-HDQDYGIH 777
Query: 798 YSFFVP-------RPTPSTPRPTPQDWLH 819
Y + VP + P P+ + W H
Sbjct: 778 YEYTVPVNRTAENQSEPEKPQDSLFIWTH 806
Score = 36.2 bits (82), Expect = 0.13
Identities = 45/188 (23%), Positives = 64/188 (34%), Gaps = 44/188 (23%)
Query: 403 PWSPCSARFITDFLDNGYGH----CL--LDKPEAPLHLPVTFPGKDYDADRQCQLTFGPD 456
PWSPCSA + G+ H C+ L P+ PG A + C+ G D
Sbjct: 869 PWSPCSAT-----CEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCE---GQD 920
Query: 457 SRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC------LHMD 510
C ++W + + W C +Q G+C +
Sbjct: 921 ----------CLSIWEASEWS-QCSASCGKGVWKRTVACTNSQ----GKCDASTRPRAEE 965
Query: 511 QLQDFNIPQAGGWGPW--GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCE--GRRTRF 566
+D++ G W G W CS TCG G+Q C V G C + +
Sbjct: 966 ACEDYS-----GCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPY 1020
Query: 567 RSCNTEDC 574
R C E C
Sbjct: 1021 RQCYQEVC 1028
Score = 33.9 bits (76), Expect = 0.64
Identities = 21/60 (35%), Positives = 24/60 (40%), Gaps = 18/60 (30%)
Query: 527 GPWGDCSRTCGGGVQFSSRDC-----------TRPVPRNGGKYCEG-RRTRFRSCNTEDC 574
GPW CS TC G Q C TRP+ YC G R +SC +DC
Sbjct: 868 GPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPL------YCPGPRPAAVQSCEGQDC 921
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1
motif, 2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 331 bits (849), Expect = 1e-90
Identities = 249/765 (32%), Positives = 365/765 (47%), Gaps = 74/765 (9%)
Query: 73 PGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQ-----APELLGGAEPGTY 127
PGS L + FG L L L ++ + G T+++ G+ LLG
Sbjct: 105 PGS----HLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSC----L 156
Query: 128 LTGTING--DPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPG-AHILRRK 184
G + G + SVA + DG L G+++ E ++PLE G G H++ R+
Sbjct: 157 YVGDVAGLAEASSVALSNCDG--LAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRR 214
Query: 185 SPASGQ--GPMC-----------NVKAPLG----SPSPRPRRAKRFASLSRF-VETLVVA 226
P S GP ++ LG + RRA+R A+ + +E L+
Sbjct: 215 PPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGV 274
Query: 227 DDKMAAFHGAG-LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGP--QVGP 283
DD + FHG +++YLLT+M + + S+ +++V+ R+++L G+ ++G
Sbjct: 275 DDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIG- 333
Query: 284 SAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPAR 343
+ +Q+L + C W P+ ++ D AI TRQD G A V +C P R
Sbjct: 334 NPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDF---GPSGMQGYAPVTGMCHPVR 390
Query: 344 SCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEP 403
SC + +DG SAF AHE GHV M HD L + +MAP++
Sbjct: 391 SCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGS---IMAPLVQAAFHRFH 447
Query: 404 WSPCSARFITDFLDNGYGHCLLDKPEAP--LHLPVTFPGKDYDADRQCQLTFGPDSRHCP 461
WS CS + ++ +L + CLLD P A LP PG Y + QC+ FG C
Sbjct: 448 WSRCSQQELSRYLHSY--DCLLDDPFAHDWPALP-QLPGLHYSMNEQCRFDFGLGYMMCT 504
Query: 462 QLPP--PCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQ 519
PC LWCS H + C+TK P DGT C P + C G C+ L + +
Sbjct: 505 AFRTFDPCKQLWCS-HPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIW---LTPDILKR 560
Query: 520 AGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSA 579
G WG W P+G CSRTCG GV+F +R C P P NGG+ C G F+ C+ +DCP S
Sbjct: 561 DGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCP-DSL 619
Query: 580 LTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVV 639
FREEQC ++ F+ W+P A +++C L C+++ G ++ V
Sbjct: 620 ADFREEQCRQWDL---YFEHGDAQHHWLPHEHRDA-KERCHLYCESRETGEVVSMKRMVH 675
Query: 640 DGTPCS-PDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKF--R 696
DGT CS D+ S+CV+G C GCD +IGS K+ DKC VCGGD S C G+F + +
Sbjct: 676 DGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKK 735
Query: 697 YGYNNVVTIPAGATHILVRQQGNPGHRSIYLALK-LPDGSYALNGEYTLMPSPTDVVLPG 755
+GY + IPAGA H+L+++ H +LA+K L G + LN E + S + G
Sbjct: 736 HGYIKMFEIPAGARHLLIQEVDATSH---HLAVKNLETGKFILNEENDVDASSKTFIAMG 792
Query: 756 AVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSF 800
V Y ETL GPL +T+ V+ G DTR+ ++
Sbjct: 793 -VEWEYRDED-GRETLQTMGPLHGTITVLVIPVG---DTRVSLTY 832
Score = 36.6 bits (83), Expect = 0.099
Identities = 22/73 (30%), Positives = 31/73 (42%), Gaps = 5/73 (6%)
Query: 529 WGDCSRTCGGGVQFSSRDCTR-----PVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFR 583
W CS+ CGGG QF+ C R V R + R+CN ++C +T
Sbjct: 863 WSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGE 922
Query: 584 EEQCAAYNHRTDL 596
E C+ RT +
Sbjct: 923 WEPCSQTCGRTGM 935
Score = 35.0 bits (79), Expect = 0.29
Identities = 21/56 (37%), Positives = 29/56 (51%), Gaps = 7/56 (12%)
Query: 527 GPWGDCSRTCG-GGVQFSSRDCTRPVPRN-----GGKYC-EGRRTRFRSCNTEDCP 575
G W CS+TCG G+Q S C +P+ N K+C + R R+C+ E CP
Sbjct: 921 GEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCP 976
Score = 34.7 bits (78), Expect = 0.38
Identities = 21/54 (38%), Positives = 23/54 (42%), Gaps = 3/54 (5%)
Query: 524 GPW--GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCP 575
G W GPW CS TCG G Q C R + G E R R+C CP
Sbjct: 977 GRWRAGPWSQCSVTCGNGTQERPVLC-RTADDSFGICQEERPETARTCRLGPCP 1029
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 325 bits (833), Expect = 1e-88
Identities = 240/763 (31%), Positives = 348/763 (45%), Gaps = 57/763 (7%)
Query: 69 GSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLGGA-EPGTY 127
G++ PG L + FG+ L L L + + V G +V++ EL
Sbjct: 94 GTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECV 153
Query: 128 LTGTINGDP-ESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRK-- 184
TG + G P +VA + DG L G+++ + ++PLE G H++ R+
Sbjct: 154 YTGGVTGMPGAAVAISNCDG--LAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREA 211
Query: 185 -------------SPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRF-VETLVVADDKM 230
+ A G G + N+ +G R +R A + +E L+V DD +
Sbjct: 212 VQQEWAEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSV 271
Query: 231 AAFHGAG-LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGP-SAAQT 288
FHG ++ Y+LT+M + + S+ +++ + RL+++G + + + +++
Sbjct: 272 VRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRS 331
Query: 289 LRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIV 348
L C W + S +H D + TRQD G S G A V +C P RSCA+
Sbjct: 332 LEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF-GPS-----GYAPVTGMCHPLRSCALN 385
Query: 349 EDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCS 408
+DG SAF AHE GHV M HD + L + VMAP++ WS CS
Sbjct: 386 HEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGS---VMAPLVQAAFHRFHWSRCS 442
Query: 409 ARFITDFLDNGYGHCLLDKPEAPLH-LPVTFPGKDYDADRQCQLTFGPDSRHCPQLPP-- 465
++ +L + CLLD P P P PG +Y D QC+ FG + C
Sbjct: 443 KLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFE 500
Query: 466 PCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGP 525
PC LWCS H + C+TK P DGT C P + C G C+ Q + Q GGW
Sbjct: 501 PCKQLWCS-HPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYG--QDGGWSS 557
Query: 526 WGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREE 585
W +G CSR+CGGGV+ SR C P P GG+ C G ++ CN+E+CP G+ FR +
Sbjct: 558 WTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP-GTYEDFRAQ 616
Query: 586 QCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCS 645
QCA R + WVP Y +C+L CQ+ G + V DGT CS
Sbjct: 617 QCA---KRNSYYVHQNAKHSWVP-YEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCS 672
Query: 646 -PDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKF--RYGYNNV 702
D SVC +G C+ GCD+ +GS K DKC VCGGD S C G+ K + G +
Sbjct: 673 YRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKL 732
Query: 703 VTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYS 762
V IPAGA HI + HR + GS+ LN + S T A+ L +
Sbjct: 733 VQIPAGARHIQIEALEKSPHRIV--VKNQVTGSFILNPKGKEATSRTFT----AMGLEWE 786
Query: 763 GATA-ASETLSGHGPLAQPLTLQVL--VAGNPQDTRLRYSFFV 802
A A E+L GPL + + + L G P+ + L Y + +
Sbjct: 787 DAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSS-LAYKYVI 828
Score = 35.0 bits (79), Expect = 0.29
Identities = 28/83 (33%), Positives = 34/83 (40%), Gaps = 18/83 (21%)
Query: 488 PWADGT-PCGPAQACMGGR------CLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGV 540
P ++GT PA+AC G R CL +P W G W CS TCG G+
Sbjct: 938 PLSNGTHKVMPAKACAGDRPEARRPCLR--------VPCPAQWR-LGAWSQCSATCGEGI 988
Query: 541 QFSSRDCTRPVPRNGGKYCEGRR 563
Q R N +CEG R
Sbjct: 989 Q--QRQVVCRTNANSLGHCEGDR 1009
Score = 34.3 bits (77), Expect = 0.49
Identities = 11/21 (52%), Positives = 14/21 (66%)
Query: 529 WGDCSRTCGGGVQFSSRDCTR 549
W CS+ CGGG+QF+ C R
Sbjct: 856 WAPCSKACGGGIQFTKYGCRR 876
Score = 30.4 bits (67), Expect = 7.1
Identities = 22/55 (40%), Positives = 24/55 (43%), Gaps = 9/55 (16%)
Query: 529 WGDCSRTCGG-GVQFSSRDCTRPVPRNG------GKYCEGRRTRF-RSCNTEDCP 575
WG CSR+CG GVQ C P+ NG K C G R R C CP
Sbjct: 916 WGACSRSCGKLGVQTRGIQCLLPL-SNGTHKVMPAKACAGDRPEARRPCLRVPCP 969
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1
motif, 14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 325 bits (833), Expect = 1e-88
Identities = 238/763 (31%), Positives = 346/763 (45%), Gaps = 54/763 (7%)
Query: 69 GSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLGGA-EPGTY 127
G++ PG L + FG+ L L L + + V G +V++ EL
Sbjct: 94 GTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECV 153
Query: 128 LTGTINGDP-ESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRK-- 184
TG + G P +VA + DG L G+++ + ++PLE G H++ R+
Sbjct: 154 YTGGVTGMPGAAVAISNCDG--LAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREA 211
Query: 185 -------------SPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRF-VETLVVADDKM 230
+ A G G + N+ +G R +R A + +E L+V DD +
Sbjct: 212 VQQEWAEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSV 271
Query: 231 AAFHGAG-LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGP-SAAQT 288
FHG ++ Y+LT+M + + S+ +++ + RL+++G + + + +++
Sbjct: 272 VRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRS 331
Query: 289 LRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIV 348
L C W + S +H D + TRQD G A V +C P RSCA+
Sbjct: 332 LEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF---GPSGMQGYAPVTGMCHPLRSCALN 388
Query: 349 EDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCS 408
+DG SAF AHE GHV M HD + L + VMAP++ WS CS
Sbjct: 389 HEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGS---VMAPLVQAAFHRFHWSRCS 445
Query: 409 ARFITDFLDNGYGHCLLDKPEAPLH-LPVTFPGKDYDADRQCQLTFGPDSRHCPQLPP-- 465
++ +L + CLLD P P P PG +Y D QC+ FG + C
Sbjct: 446 KLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFE 503
Query: 466 PCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGP 525
PC LWCS H + C+TK P DGT C P + C G C+ Q + Q GGW
Sbjct: 504 PCKQLWCS-HPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYG--QDGGWSS 560
Query: 526 WGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREE 585
W +G CSR+CGGGV+ SR C P P GG+ C G ++ CN+E+CP G+ FR +
Sbjct: 561 WTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP-GTYEDFRAQ 619
Query: 586 QCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCS 645
QCA R + WVP Y +C+L CQ+ G + V DGT CS
Sbjct: 620 QCA---KRNSYYVHQNAKHSWVP-YEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCS 675
Query: 646 -PDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKF--RYGYNNV 702
D SVC +G C+ GCD+ +GS K DKC VCGGD S C G+ K + G +
Sbjct: 676 YRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKL 735
Query: 703 VTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYS 762
V IPAGA HI + HR + GS+ LN + S T A+ L +
Sbjct: 736 VQIPAGARHIQIEALEKSPHRIV--VKNQVTGSFILNPKGKEATSRTFT----AMGLEWE 789
Query: 763 GATA-ASETLSGHGPLAQPLTLQVL--VAGNPQDTRLRYSFFV 802
A A E+L GPL + + + L G P+ + L Y + +
Sbjct: 790 DAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSS-LAYKYVI 831
Score = 35.0 bits (79), Expect = 0.29
Identities = 28/83 (33%), Positives = 34/83 (40%), Gaps = 18/83 (21%)
Query: 488 PWADGT-PCGPAQACMGGR------CLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGV 540
P ++GT PA+AC G R CL +P W G W CS TCG G+
Sbjct: 941 PLSNGTHKVMPAKACAGDRPEARRPCLR--------VPCPAQWR-LGAWSQCSATCGEGI 991
Query: 541 QFSSRDCTRPVPRNGGKYCEGRR 563
Q R N +CEG R
Sbjct: 992 Q--QRQVVCRTNANSLGHCEGDR 1012
Score = 34.3 bits (77), Expect = 0.49
Identities = 11/21 (52%), Positives = 14/21 (66%)
Query: 529 WGDCSRTCGGGVQFSSRDCTR 549
W CS+ CGGG+QF+ C R
Sbjct: 859 WAPCSKACGGGIQFTKYGCRR 879
Score = 30.4 bits (67), Expect = 7.1
Identities = 22/55 (40%), Positives = 24/55 (43%), Gaps = 9/55 (16%)
Query: 529 WGDCSRTCGG-GVQFSSRDCTRPVPRNG------GKYCEGRRTRF-RSCNTEDCP 575
WG CSR+CG GVQ C P+ NG K C G R R C CP
Sbjct: 919 WGACSRSCGKLGVQTRGIQCLLPL-SNGTHKVMPAKACAGDRPEARRPCLRVPCP 972
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif,
3 proprotein [Homo sapiens]
Length = 1205
Score = 313 bits (801), Expect = 5e-85
Identities = 235/780 (30%), Positives = 353/780 (45%), Gaps = 79/780 (10%)
Query: 75 SGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYL------GQAPELLGGAEPGT-- 126
S P +L + AFG+ L L+ ++ + G V++ G + + +PG+
Sbjct: 74 SSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSAT 133
Query: 127 --------------YLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNS 172
Y+ ++ SVA + DG L G+++ E ++PLE G
Sbjct: 134 YRIRKTEPLQTNCAYVGDIVDIPGTSVAISNCDG--LAGMIKSDNEEYFIEPLERGKQME 191
Query: 173 AGGPGAHILR------------------RKSPASGQGPMCNVKAPLGSPSPRPRRAKRFA 214
H++ R+S G + V + R +R A
Sbjct: 192 EEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRHA 251
Query: 215 SLSRF-VETLVVADDKMAAFHGAG-LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVIL 272
+ + +E L+ DD + FHG ++ YLLT+M + + S+ +++V+ R+++L
Sbjct: 252 GENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIML 311
Query: 273 GSGEEGPQVGP-SAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLG 331
G + + + +++L + C W + + +H D AI TRQD G
Sbjct: 312 GYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDF---GPAGMQG 368
Query: 332 MADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVM 391
A V +C P RSC + +DG SAF AHE GHV M HD + G + VM
Sbjct: 369 YAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQG---NRCGDETAMGSVM 425
Query: 392 APVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKP---EAPLHLPVTFPGKDYDADRQ 448
AP++ WS CS + + ++ + CLLD P + P LP PG +Y D Q
Sbjct: 426 APLVQAAFHRYHWSRCSGQELKRYIHSY--DCLLDDPFDHDWP-KLP-ELPGINYSMDEQ 481
Query: 449 CQLTFGPDSRHCPQLPP--PCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC 506
C+ FG + C PC LWCS H + C+TK P DGT C + C G C
Sbjct: 482 CRFDFGVGYKMCTAFRTFDPCKQLWCS-HPDNPYFCKTKKGPPLDGTECAAGKWCYKGHC 540
Query: 507 LHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRF 566
+ + Q Q G WG W +G CSRTCG GV+F +R C P+P NGG+ C G +
Sbjct: 541 MWKNANQQ---KQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEY 597
Query: 567 RSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQ 626
+ CNTE+C FR +QC R F+ W+P Y P+ +C L CQ++
Sbjct: 598 QLCNTEECQKHFE-DFRAQQC---QQRNSHFEYQNTKHHWLP-YEHPDPKKRCHLYCQSK 652
Query: 627 ALGYYYVLEPRVVDGTPCS-PDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGC 685
G ++ V DGT CS D S+CV+G C+ GCD+ IGS K DKC VCGGD S C
Sbjct: 653 ETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHC 712
Query: 686 SKQSGSFRKF--RYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALK-LPDGSYALNGEY 742
G+F + + GY + IP GA H+L+++ H LA+K G Y LNG+
Sbjct: 713 RTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPH---ILAIKNQATGHYILNGKG 769
Query: 743 TLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFV 802
S T + L V Y+ E+L GPL P+ + ++ N + L Y + +
Sbjct: 770 EEAKSRTFIDL--GVEWDYN-IEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYII 826
Score = 39.3 bits (90), Expect = 0.015
Identities = 63/271 (23%), Positives = 96/271 (35%), Gaps = 49/271 (18%)
Query: 336 GTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVM 395
G + DP I +++ +S+ T + ++H++S P I+ N + +
Sbjct: 799 GPLHDPVIVLIIPQENDTRSSLTYKY-------IIHEDSVPTINSNNVIQEELDTFEWAL 851
Query: 396 AHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKD-YDADRQCQ---- 450
+ WS CS F YG C +H K R C
Sbjct: 852 ------KSWSQCSKPCGGGFQYTKYG-CRRKSDNKMVHRSFCEANKKPKPIRRMCNIQEC 904
Query: 451 ---LTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGP-AQACMGGRC 506
L + HC + C + SG+ C P DGT ++ CMG R
Sbjct: 905 THPLWVAEEWEHCTKT---CGS---SGYQLRTVRCL---QPLLDGTNRSVHSKYCMGDR- 954
Query: 507 LHMDQLQDFN-IPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEG---- 561
+ + N +P W GPW +CS TCG G + R V G +C+G
Sbjct: 955 --PESRRPCNRVPCPAQWKT-GPWSECSVTCGEGTE------VRQVLCRAGDHCDGEKPE 1005
Query: 562 --RRTRFRSCNTEDCPTGSALTFREEQCAAY 590
R + CN E C ++ + E A Y
Sbjct: 1006 SVRACQLPPCNDEPCLGDKSIFCQMEVLARY 1036
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1
motif, 19 preproprotein [Homo sapiens]
Length = 1207
Score = 309 bits (792), Expect = 6e-84
Identities = 244/793 (30%), Positives = 347/793 (43%), Gaps = 90/793 (11%)
Query: 81 LLCRLQAFGETLLLELEQDSGVQVEGLTVQY----------LGQAPELLGGAEPGTYLTG 130
+L R+ AF L L L +D V+ AP+ + G + TG
Sbjct: 165 VLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTG 224
Query: 131 TINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKS----- 185
+ P S+AS GG L+G +Q + ++PL T G P +++S
Sbjct: 225 AVLRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLND-TMAITGHPHRVYRQKRSMEEKV 283
Query: 186 --PASGQGPMCNVKAPLGSPSPRP----RRAKRFA---SLSRFVETLVVADDKMAAFHGA 236
++ C + + G P R R KR++ +ET+VVAD M ++HGA
Sbjct: 284 TEKSALHSHYCGIISDKGRPRSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSYHGA 343
Query: 237 -GLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAW 295
+R++LT++ F+H S+ V+L V +L++L +G + L SFC W
Sbjct: 344 DAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKW 403
Query: 296 QRG-----------LNTPEDSDPDHFDTAILFTRQDLC--GVSTCDTLGMADVGTVCDPA 342
Q ++T D D AIL TR+D C CDT+G+A + +C
Sbjct: 404 QHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEK 463
Query: 343 RSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEE 402
R C I ED+GL AFT AHE+GH + HDN P + + + + + V
Sbjct: 464 RKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVS--- 520
Query: 403 PWSPCSARFITDFLDNGYGHCLLD-KPEA--PLHLPVTFPGKDYDADRQCQLTFGPDSRH 459
WS CS + FL + +CLL P++ + +P PG Y AD QCQ+ FGP +
Sbjct: 521 -WSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASF 579
Query: 460 CPQLPPP-CAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIP 518
C ++ C LWC + G C+TK P DGT C + C G C +
Sbjct: 580 CQEMQHVICTGLWCK--VEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEH--- 634
Query: 519 QAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGS 578
AG W W P CSRTC G+ R C P + + C G R ++R C CP G
Sbjct: 635 LAGEWSLWSP---CSRTCSAGISSRERKC--PGLDSEARDCNGPRKQYRICENPPCPAGL 689
Query: 579 ALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRV 638
FR+ QC AY+ RT K + W P C L C +L +V
Sbjct: 690 P-GFRDWQCQAYSVRTSSPKHI---LQWQAVLDEEKP---CALFCSPVGKEQPILLSEKV 742
Query: 639 VDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFR-Y 697
+DGT C +C GRC GCD ++GS + D C VC G+G C G F R
Sbjct: 743 MDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRGA 802
Query: 698 GYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAV 757
GY V+ IPAGA I V ++ P H YLAL+ G ++N ++ + S GA
Sbjct: 803 GYVEVLVIPAGARRIKVVEE-KPAHS--YLALR-DAGKQSINSDWKIEHS-------GAF 851
Query: 758 SLRYSGAT------AASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPR-PTP--- 807
+L +G T E +S GP PL L VL+ Q+ L Y + +P P P
Sbjct: 852 NL--AGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLF-QDQNYGLHYEYTIPSDPLPENQ 908
Query: 808 STPRPTPQ-DWLH 819
S+ P P W H
Sbjct: 909 SSKAPEPLFMWTH 921
Score = 38.9 bits (89), Expect = 0.020
Identities = 19/60 (31%), Positives = 28/60 (46%), Gaps = 7/60 (11%)
Query: 529 WGDCSRTCGGGVQFSSRDCTRPVPRNGG-------KYCEGRRTRFRSCNTEDCPTGSALT 581
W DC TCGGG + ++ CT+ + +N KY + R CN + C T +T
Sbjct: 924 WEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMT 983
Score = 34.3 bits (77), Expect = 0.49
Identities = 20/70 (28%), Positives = 28/70 (40%), Gaps = 13/70 (18%)
Query: 527 GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYC--EGRRTRFRSCNTEDC---------- 574
G W CS TCG G+Q C + G C + +R C+ + C
Sbjct: 1094 GDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNEKINVNTIT 1153
Query: 575 -PTGSALTFR 583
P +ALTF+
Sbjct: 1154 SPRLAALTFK 1163
Score = 30.8 bits (68), Expect = 5.4
Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 6/54 (11%)
Query: 529 WGDCSRTCGGGVQFSSRDCTRPVP-----RNGGKYCEG-RRTRFRSCNTEDCPT 576
W CSRTCG G+Q CT+ + R + C G + + C +DC T
Sbjct: 985 WTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMT 1038
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 268 bits (686), Expect = 1e-71
Identities = 200/647 (30%), Positives = 289/647 (44%), Gaps = 57/647 (8%)
Query: 198 APLGSPSPRP------RRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAK 251
APL P P +R +R A +E LV + H +RY+LT + A+
Sbjct: 54 APLKGRPPSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAE 113
Query: 252 AFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFD 311
+ PS+ + + ++VIL E P + + +L S C W + +N +D+DP H D
Sbjct: 114 LLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHAD 173
Query: 312 TAILFTRQDL-CGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNML 370
+ TR DL G+ +G C P SC I ED G T AHE+GH F +
Sbjct: 174 LVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLE 233
Query: 371 HDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPE- 429
HD + S GP S HVMA A WSPCS R + L G C+ D P
Sbjct: 234 HDGAPG--SGCGP---SGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRP 288
Query: 430 ---APLHLPVTFPGKDYDADRQCQLTFGPDSRHCP---QLPPPCAALWCSGHLNGHAMCQ 483
+ H P PG Y A+ QC++ FGP + C + C AL C + C
Sbjct: 289 QPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCS 348
Query: 484 TKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFS 543
P DGT CG + C GRC + +L G W WGP CSR+CGGGV
Sbjct: 349 RLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVH-GRWSSWGPRSPCSRSCGGGVVTR 407
Query: 544 SRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTD--LFKSFP 601
R C P P GG+ C G + CNT+ C + L F +QCA RTD +S P
Sbjct: 408 RRQCNNPRPAFGGRACVGADLQAEMCNTQACEK-TQLEFMSQQCA----RTDGQPLRSSP 462
Query: 602 GPMDWVPRYTGVAPQDQCKLTCQ--AQALGYYYVLE--PRVVDGTPCSPD------SSSV 651
G + + P Q C+ +A+G ++++ +DGT C P + S+
Sbjct: 463 GGASFY-HWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSL 521
Query: 652 CVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFR-YGYNNVVTIPAGAT 710
CV G C GCD + S++ +D+C VCGGD S CS + GSF R Y +T+ T
Sbjct: 522 CVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLT 581
Query: 711 HILVRQQGNPGHRSIY--LALKLPDGSYALNGEYTLMPSPT--DVVLPGAVSLRYS---G 763
+ + HR ++ LA+++ G Y + G+ ++ P+ T ++ G V R +
Sbjct: 582 SVYI-----ANHRPLFTHLAVRI-GGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTED 635
Query: 764 ATAASETLSGHGPLAQPLTLQVL-----VAGNPQDTRLRYSFFVPRP 805
E + GPL + +QV GN + +++F P+P
Sbjct: 636 RLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKP 682
Score = 31.2 bits (69), Expect = 4.2
Identities = 32/130 (24%), Positives = 43/130 (33%), Gaps = 32/130 (24%)
Query: 440 GKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQ 499
G++ D QCQ P+ + L P C W L C CG
Sbjct: 986 GEEILLDTQCQGLPRPEPQEACSLEP-CPPRWKVMSLGP---CSAS---------CGLGT 1032
Query: 500 ACMGGRCLHMDQLQDFNIPQAGGWG-----------------PW--GPWGDCSRTCGGGV 540
A C+ +DQ QD + +A W G W +CS +CG G+
Sbjct: 1033 ARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGI 1092
Query: 541 QFSSRDCTRP 550
Q C P
Sbjct: 1093 QRRRDTCLGP 1102
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 268 bits (686), Expect = 1e-71
Identities = 200/647 (30%), Positives = 289/647 (44%), Gaps = 57/647 (8%)
Query: 198 APLGSPSPRP------RRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAK 251
APL P P +R +R A +E LV + H +RY+LT + A+
Sbjct: 54 APLKGRPPSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAE 113
Query: 252 AFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFD 311
+ PS+ + + ++VIL E P + + +L S C W + +N +D+DP H D
Sbjct: 114 LLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHAD 173
Query: 312 TAILFTRQDL-CGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNML 370
+ TR DL G+ +G C P SC I ED G T AHE+GH F +
Sbjct: 174 LVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLE 233
Query: 371 HDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPE- 429
HD + S GP S HVMA A WSPCS R + L G C+ D P
Sbjct: 234 HDGAPG--SGCGP---SGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRP 288
Query: 430 ---APLHLPVTFPGKDYDADRQCQLTFGPDSRHCP---QLPPPCAALWCSGHLNGHAMCQ 483
+ H P PG Y A+ QC++ FGP + C + C AL C + C
Sbjct: 289 QPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCS 348
Query: 484 TKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFS 543
P DGT CG + C GRC + +L G W WGP CSR+CGGGV
Sbjct: 349 RLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVH-GRWSSWGPRSPCSRSCGGGVVTR 407
Query: 544 SRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTD--LFKSFP 601
R C P P GG+ C G + CNT+ C + L F +QCA RTD +S P
Sbjct: 408 RRQCNNPRPAFGGRACVGADLQAEMCNTQACEK-TQLEFMSQQCA----RTDGQPLRSSP 462
Query: 602 GPMDWVPRYTGVAPQDQCKLTCQ--AQALGYYYVLE--PRVVDGTPCSPD------SSSV 651
G + + P Q C+ +A+G ++++ +DGT C P + S+
Sbjct: 463 GGASFY-HWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSL 521
Query: 652 CVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFR-YGYNNVVTIPAGAT 710
CV G C GCD + S++ +D+C VCGGD S CS + GSF R Y +T+ T
Sbjct: 522 CVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLT 581
Query: 711 HILVRQQGNPGHRSIY--LALKLPDGSYALNGEYTLMPSPT--DVVLPGAVSLRYS---G 763
+ + HR ++ LA+++ G Y + G+ ++ P+ T ++ G V R +
Sbjct: 582 SVYI-----ANHRPLFTHLAVRI-GGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTED 635
Query: 764 ATAASETLSGHGPLAQPLTLQVL-----VAGNPQDTRLRYSFFVPRP 805
E + GPL + +QV GN + +++F P+P
Sbjct: 636 RLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKP 682
Score = 31.2 bits (69), Expect = 4.2
Identities = 32/130 (24%), Positives = 43/130 (33%), Gaps = 32/130 (24%)
Query: 440 GKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQ 499
G++ D QCQ P+ + L P C W L C CG
Sbjct: 986 GEEILLDTQCQGLPRPEPQEACSLEP-CPPRWKVMSLGP---CSAS---------CGLGT 1032
Query: 500 ACMGGRCLHMDQLQDFNIPQAGGWG-----------------PW--GPWGDCSRTCGGGV 540
A C+ +DQ QD + +A W G W +CS +CG G+
Sbjct: 1033 ARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGI 1092
Query: 541 QFSSRDCTRP 550
Q C P
Sbjct: 1093 QRRRDTCLGP 1102
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 244 bits (624), Expect = 2e-64
Identities = 191/643 (29%), Positives = 278/643 (43%), Gaps = 80/643 (12%)
Query: 198 APLGSPSPRP------RRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAK 251
APL P P +R +R A +E LV + H +RY+LT + A+
Sbjct: 54 APLKGRPPSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAE 113
Query: 252 AFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFD 311
+ PS+ + + ++VIL E P + + +L S C W + +N +D+DP H D
Sbjct: 114 LLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHAD 173
Query: 312 TAILFTRQDL-CGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNML 370
+ TR DL G+ +G C P SC I ED G T AHE+GH F +
Sbjct: 174 LVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLE 233
Query: 371 HDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEA 430
HD + S GP S HVMA A WSPCS R + L
Sbjct: 234 HDGAPG--SGCGP---SGHVMASDGAAPRAGLAWSPCSRRQLLSLLS------------- 275
Query: 431 PLHLPVTFPGKDYDADRQCQLTFGPDSRHCP---QLPPPCAALWCSGHLNGHAMCQTKHS 487
A+ QC++ FGP + C + C AL C + C
Sbjct: 276 --------------ANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLV 321
Query: 488 PWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDC 547
P DGT CG + C GRC + +L G W WGP CSR+CGGGV R C
Sbjct: 322 PLLDGTECGVEKWCSKGRCRSLVELTPIAAVH-GRWSSWGPRSPCSRSCGGGVVTRRRQC 380
Query: 548 TRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTD--LFKSFPGPMD 605
P P GG+ C G + CNT+ C + L F +QCA RTD +S PG
Sbjct: 381 NNPRPAFGGRACVGADLQAEMCNTQACEK-TQLEFMSQQCA----RTDGQPLRSSPGGAS 435
Query: 606 WVPRYTGVAPQDQCKLTCQ--AQALGYYYVLE--PRVVDGTPCSPD------SSSVCVQG 655
+ + P Q C+ +A+G ++++ +DGT C P + S+CV G
Sbjct: 436 FY-HWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSG 494
Query: 656 RCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFR-YGYNNVVTIPAGATHILV 714
C GCD + S++ +D+C VCGGD S CS + GSF R Y +T+ T + +
Sbjct: 495 SCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYI 554
Query: 715 RQQGNPGHRSIY--LALKLPDGSYALNGEYTLMPSPT--DVVLPGAVSLRYS---GATAA 767
HR ++ LA+++ G Y + G+ ++ P+ T ++ G V R +
Sbjct: 555 -----ANHRPLFTHLAVRI-GGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPR 608
Query: 768 SETLSGHGPLAQPLTLQVL-----VAGNPQDTRLRYSFFVPRP 805
E + GPL + +QV GN + +++F P+P
Sbjct: 609 LEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKP 651
Score = 31.2 bits (69), Expect = 4.2
Identities = 32/130 (24%), Positives = 43/130 (33%), Gaps = 32/130 (24%)
Query: 440 GKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQ 499
G++ D QCQ P+ + L P C W L C CG
Sbjct: 955 GEEILLDTQCQGLPRPEPQEACSLEP-CPPRWKVMSLGP---CSAS---------CGLGT 1001
Query: 500 ACMGGRCLHMDQLQDFNIPQAGGWG-----------------PW--GPWGDCSRTCGGGV 540
A C+ +DQ QD + +A W G W +CS +CG G+
Sbjct: 1002 ARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGI 1061
Query: 541 QFSSRDCTRP 550
Q C P
Sbjct: 1062 QRRRDTCLGP 1071
>gi|226442878 ADAMTS-like 5 [Homo sapiens]
Length = 471
Score = 169 bits (428), Expect = 1e-41
Identities = 119/312 (38%), Positives = 153/312 (49%), Gaps = 33/312 (10%)
Query: 521 GGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSAL 580
G W PW W CS +CG GV SR C R +P G + C G +R C DCP G A+
Sbjct: 36 GEWTPWVSWTRCSSSCGRGVSVRSRRCLR-LP--GEEPCWGDSHEYRLCQLPDCPPG-AV 91
Query: 581 TFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVD 640
FR+ QCA YN R L WVP + AP +QC L C A+ +Y+ RV+D
Sbjct: 92 PFRDLQCALYNGRPVL--GTQKTYQWVPFHG--AP-NQCDLNCLAEGHAFYHSFG-RVLD 145
Query: 641 GTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGC------SKQSGSFRK 694
GT CSP + VCV GRC+ AGCD ++GS D+C CGG C + +G+F
Sbjct: 146 GTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFA- 204
Query: 695 FRYGYNNVVTIPAGATHILVRQQGNPGHRS-IYLALKLPDGSYALNGEYTLMPSPTDVVL 753
GY NV IP GA HI V HRS +LAL DG Y LNG + + SP
Sbjct: 205 ---GYWNVTLIPEGARHIRVE------HRSRNHLALMGGDGRYVLNGHWVV--SPPGTYE 253
Query: 754 PGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPRP--TPSTPR 811
+ Y+ T ETL GP + L LQVL+ + + + F++PR +P R
Sbjct: 254 AAGTHVVYTRDTGPQETLQAAGPTSHDLLLQVLL--QEPNPGIEFEFWLPRERYSPFQAR 311
Query: 812 PTPQDWLHRRAQ 823
W R+ Q
Sbjct: 312 VQALGWPLRQPQ 323
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 161 bits (408), Expect = 2e-39
Identities = 100/293 (34%), Positives = 135/293 (46%), Gaps = 44/293 (15%)
Query: 519 QAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGS 578
Q+ WGPW W CSRTCGGGV F R C R+GG C G RSC TE CP G
Sbjct: 25 QSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQ-RRDGGSSCVGPARSHRSCRTESCPDG- 82
Query: 579 ALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRV 638
A FR EQCA ++ + + W+P Y+ AP ++C+L C + +YY V
Sbjct: 83 ARDFRAEQCAEFDGAEFQGRRYR----WLPYYS--AP-NKCELNCIPKGENFYYKHREAV 135
Query: 639 VDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYG 698
VDGTPC P VCV G C GCD + S K+ DKC+ CGGDG+ C +G+F
Sbjct: 136 VDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTF------ 189
Query: 699 YNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVS 758
+ A+K G Y LNG +T+ + LP A +
Sbjct: 190 ----------------------DANDLSRAVKNVRGEYYLNGHWTIEAAR---ALPAAST 224
Query: 759 L----RYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPRPTP 807
+ R + A E L GP ++PL ++++ Y + RP+P
Sbjct: 225 ILHYERGAEGDLAPERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSP 277
Score = 47.4 bits (111), Expect = 6e-05
Identities = 52/188 (27%), Positives = 71/188 (37%), Gaps = 35/188 (18%)
Query: 404 WSPCSARFITDFLDNGYGH------CLLDKPEAPLHLPVTFPGKDYDADRQ-CQLTFGPD 456
WS CSA + G GH C +D P H+ P ADR+ C L
Sbjct: 286 WSDCSA-------ECGGGHQSRLVFCTIDHEAYPDHMCQRQPRP---ADRRSCNL----- 330
Query: 457 SRHCPQLPPPCAALW--CSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMD---- 510
CP+ A W CS G + ++ + +DG G +A C +
Sbjct: 331 -HPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGA--GIQEAVEEAECAGLPGKPP 387
Query: 511 QLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDC---TRPVPRNGGKYCEGRRTRFR 567
+Q N+ + W P PWG+CS +CG GV+ S C + E R
Sbjct: 388 AIQACNLQRCAAWSP-EPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTE 446
Query: 568 SCNTEDCP 575
C EDCP
Sbjct: 447 PCVHEDCP 454
Score = 37.7 bits (86), Expect = 0.045
Identities = 37/144 (25%), Positives = 44/144 (30%), Gaps = 25/144 (17%)
Query: 518 PQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYC--EGRRTRFRSCNTEDCP 575
P G G W DCS CGGG Q CT C + R RSCN CP
Sbjct: 275 PSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCP 334
Query: 576 TGSALTFREEQCAAYNHRTDLFKSFPGPMDWVP--RYTGVAPQDQCKLTCQAQALGYYYV 633
T +K+ P W P G Q + + G
Sbjct: 335 -----------------ETKRWKAGP----WAPCSASCGGGSQSRSVYCISSDGAGIQEA 373
Query: 634 LEPRVVDGTPCSPDSSSVCVQGRC 657
+E G P P + C RC
Sbjct: 374 VEEAECAGLPGKPPAIQACNLQRC 397
Score = 33.1 bits (74), Expect = 1.1
Identities = 14/48 (29%), Positives = 20/48 (41%)
Query: 527 GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDC 574
G WG CS++C G + C P + G + CNT+ C
Sbjct: 464 GTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPC 511
Score = 32.7 bits (73), Expect = 1.4
Identities = 31/124 (25%), Positives = 43/124 (34%), Gaps = 23/124 (18%)
Query: 467 CAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC-LHMDQLQDFNIPQAGGWGP 525
C+A GH + C H + D + C LH P+ W
Sbjct: 289 CSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHP-------CPETKRWKA 341
Query: 526 WGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCE-----------GRRTRFRSCNTEDC 574
GPW CS +CGGG Q S C + +G E G+ ++CN + C
Sbjct: 342 -GPWAPCSASCGGGSQSRSVYC---ISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397
Query: 575 PTGS 578
S
Sbjct: 398 AAWS 401
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 156 bits (394), Expect = 9e-38
Identities = 100/286 (34%), Positives = 141/286 (49%), Gaps = 26/286 (9%)
Query: 521 GGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSAL 580
G W WGPW +CSRTCGGG +S R C K CEGR R+R+C+ DCP A
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCL------SSKSCEGRNIRYRTCSNVDCPP-EAG 86
Query: 581 TFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVD 640
FR +QC+A+N K +W+P P + C L CQA+ L P+V+D
Sbjct: 87 DFRAQQCSAHND----VKHHGQFYEWLP--VSNDPDNPCSLKCQAKGTTLVVELAPKVLD 140
Query: 641 GTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFR---KFRY 697
GT C +S +C+ G C GCD +GS K D C VC GDGS C G ++
Sbjct: 141 GTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATK 200
Query: 698 GYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAV 757
+ VV IP G+ HI + +G P H +YL K G+ GE +L + T +V +V
Sbjct: 201 SDDTVVAIPYGSRHIRLVLKG-PDH--LYLETKTLQGT---KGENSLSSTGTFLVDNSSV 254
Query: 758 SLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVP 803
+ E L GPL +++ +G+ D+ +++ F+ P
Sbjct: 255 DFQ---KFPDKEILRMAGPLTADFIVKIRNSGS-ADSTVQFIFYQP 296
Score = 37.0 bits (84), Expect = 0.076
Identities = 23/68 (33%), Positives = 31/68 (45%), Gaps = 9/68 (13%)
Query: 515 FNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNG-----GKYCEGRRTRF-RS 568
FN P A W P W CSRTCGGGVQ C + + +C + ++
Sbjct: 726 FNCPPA--WYP-AQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQA 782
Query: 569 CNTEDCPT 576
C +DCP+
Sbjct: 783 CKKDDCPS 790
Score = 32.3 bits (72), Expect = 1.9
Identities = 17/52 (32%), Positives = 24/52 (46%), Gaps = 8/52 (15%)
Query: 532 CSRTCGGGVQFSSRDC--TRPVPRNGGKYCE------GRRTRFRSCNTEDCP 575
CS TCGGG Q +S +C R +YC + + + CN + CP
Sbjct: 309 CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Score = 31.2 bits (69), Expect = 4.2
Identities = 16/55 (29%), Positives = 23/55 (41%), Gaps = 7/55 (12%)
Query: 528 PWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRF-------RSCNTEDCP 575
PW CS +CGGG+Q + C + E + + + CN DCP
Sbjct: 384 PWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
Score = 31.2 bits (69), Expect = 4.2
Identities = 27/103 (26%), Positives = 39/103 (37%), Gaps = 21/103 (20%)
Query: 491 DGTPCGPAQACMGGRCLHMDQLQDFNIPQAGG-------------WGPWGPWGDCSRTCG 537
+G +AC G C ++ +FN + G W G + CS +CG
Sbjct: 568 EGPKPASQRACYAGPC--SGEIPEFNPDETDGLFGGLQDFDELYDWEYEG-FTKCSESCG 624
Query: 538 GGVQFSSRDCTRPVPRNGGK--YCEGRR---TRFRSCNTEDCP 575
GGVQ + C R + C R +SCN + CP
Sbjct: 625 GGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCP 667
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 156 bits (394), Expect = 9e-38
Identities = 100/286 (34%), Positives = 141/286 (49%), Gaps = 26/286 (9%)
Query: 521 GGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSAL 580
G W WGPW +CSRTCGGG +S R C K CEGR R+R+C+ DCP A
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCL------SSKSCEGRNIRYRTCSNVDCPP-EAG 86
Query: 581 TFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVD 640
FR +QC+A+N K +W+P P + C L CQA+ L P+V+D
Sbjct: 87 DFRAQQCSAHND----VKHHGQFYEWLP--VSNDPDNPCSLKCQAKGTTLVVELAPKVLD 140
Query: 641 GTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFR---KFRY 697
GT C +S +C+ G C GCD +GS K D C VC GDGS C G ++
Sbjct: 141 GTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATK 200
Query: 698 GYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAV 757
+ VV IP G+ HI + +G P H +YL K G+ GE +L + T +V +V
Sbjct: 201 SDDTVVAIPYGSRHIRLVLKG-PDH--LYLETKTLQGT---KGENSLSSTGTFLVDNSSV 254
Query: 758 SLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVP 803
+ E L GPL +++ +G+ D+ +++ F+ P
Sbjct: 255 DFQ---KFPDKEILRMAGPLTADFIVKIRNSGS-ADSTVQFIFYQP 296
Score = 32.3 bits (72), Expect = 1.9
Identities = 17/52 (32%), Positives = 24/52 (46%), Gaps = 8/52 (15%)
Query: 532 CSRTCGGGVQFSSRDC--TRPVPRNGGKYCE------GRRTRFRSCNTEDCP 575
CS TCGGG Q +S +C R +YC + + + CN + CP
Sbjct: 309 CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Score = 31.2 bits (69), Expect = 4.2
Identities = 16/55 (29%), Positives = 23/55 (41%), Gaps = 7/55 (12%)
Query: 528 PWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRF-------RSCNTEDCP 575
PW CS +CGGG+Q + C + E + + + CN DCP
Sbjct: 384 PWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 155 bits (393), Expect = 1e-37
Identities = 86/219 (39%), Positives = 113/219 (51%), Gaps = 21/219 (9%)
Query: 521 GGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSAL 580
G W WG W DCSRTCGGG +S R C G+ CEG+ R+++C+ DCP A
Sbjct: 76 GNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPP-DAE 128
Query: 581 TFREEQCAAYNHRTDLFKSFPGPM-DWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVV 639
FR +QC+AYN + G +W+PRY P C L C AQ L P+V+
Sbjct: 129 DFRAQQCSAYND-----VQYQGHYYEWLPRYND--PAAPCALKCHAQGQNLVVELAPKVL 181
Query: 640 DGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGC---SKQSGSFRKFR 696
DGT C+ DS +C+ G C GCDR +GS K D C VC GDGS C QS S
Sbjct: 182 DGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPE 241
Query: 697 YGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGS 735
NV+ +P G+ + + +G P H +++ K GS
Sbjct: 242 KREENVIAVPLGSRSVRITVKG-PAH--LFIESKTLQGS 277
Score = 43.5 bits (101), Expect = 8e-04
Identities = 35/115 (30%), Positives = 45/115 (39%), Gaps = 28/115 (24%)
Query: 489 WADGTPCGPAQACMGGR------CLHMDQLQDFN------------IPQAGGWGP----W 526
+A TPC C+GG CLH+ Q N + QA P W
Sbjct: 650 YAGFTPC--TATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRW 707
Query: 527 --GPWGDCSRTCGGGVQFSSRDCTRP--VPRNGGKYCEGRRTRFRSCNTEDCPTG 577
G WG CS TCG G+Q C P P + + + ++CN DCP G
Sbjct: 708 HVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPG 762
Score = 37.4 bits (85), Expect = 0.058
Identities = 36/144 (25%), Positives = 52/144 (36%), Gaps = 19/144 (13%)
Query: 446 DRQCQLTFGPDSRHCPQLPPPCAALW-------CSGHLNGHAMCQTKHSPWADGTPCGPA 498
D C + P + PC W CS + + TP P
Sbjct: 682 DSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPA-PP 740
Query: 499 QACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGG-- 556
+ C + + F+ P GW W CSRTCGGG Q + R R + +G
Sbjct: 741 EECRDEKPHALQACNQFDCPP--GWHI-EEWQQCSRTCGGGTQ-NRRVTCRQLLTDGSFL 796
Query: 557 ----KYCEG-RRTRFRSCNTEDCP 575
+ C+G + + +SC DCP
Sbjct: 797 NLSDELCQGPKASSHKSCARTDCP 820
Score = 32.7 bits (73), Expect = 1.4
Identities = 23/66 (34%), Positives = 25/66 (37%), Gaps = 12/66 (18%)
Query: 518 PQAGGWGPWGPWGDCSRTCGG-GVQFSSRDCTRPVPRNGGKYCEG-------RRTRFRSC 569
PQ W P G W CS TCG G + C V NG + E F C
Sbjct: 1423 PQEPFWEP-GNWSHCSATCGHLGARIQRPQC---VMANGQEVSEALCDHLQKPLAGFEPC 1478
Query: 570 NTEDCP 575
N DCP
Sbjct: 1479 NIRDCP 1484
Score = 31.6 bits (70), Expect = 3.2
Identities = 18/64 (28%), Positives = 27/64 (42%), Gaps = 7/64 (10%)
Query: 528 PWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRF-------RSCNTEDCPTGSAL 580
PW CS +CGGG+Q S C E + + ++CN DCP A+
Sbjct: 426 PWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAM 485
Query: 581 TFRE 584
+ +
Sbjct: 486 EWSQ 489
Score = 31.2 bits (69), Expect = 4.2
Identities = 19/72 (26%), Positives = 32/72 (44%), Gaps = 18/72 (25%)
Query: 532 CSRTCGGGVQFSSRDCT-----RPVPRNGGKYCE------GRRTRFRSCNTEDCPTGSAL 580
C+ TCGGG Q +S +C R VP + YC + + + C+ + CP+
Sbjct: 351 CTVTCGGGYQLNSAECVDIRLKRVVPDH---YCHYYPENVKPKPKLKECSMDPCPSSDGF 407
Query: 581 TFREEQCAAYNH 592
++ Y+H
Sbjct: 408 ----KEIMPYDH 415
Score = 31.2 bits (69), Expect = 4.2
Identities = 30/103 (29%), Positives = 36/103 (34%), Gaps = 21/103 (20%)
Query: 528 PWGDCSRTCGGGVQFSSRDC------TRPVPRNGGKYCEG-RRTRFRSCNTEDCPTGSAL 580
PW CS TCG GVQ C T+ + CEG + R C E C
Sbjct: 572 PWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEAC------ 625
Query: 581 TFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTC 623
+E A+ L + DW Y G P C TC
Sbjct: 626 ---DESPASRELDIPLPEDSETTYDW--EYAGFTP---CTATC 660
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 155 bits (392), Expect = 1e-37
Identities = 136/460 (29%), Positives = 205/460 (44%), Gaps = 54/460 (11%)
Query: 73 PGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQ-----APELLGGAEPGTY 127
PGS L + FG L L L ++ + G T+++ G+ LLG
Sbjct: 105 PGS----HLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSC----L 156
Query: 128 LTGTING--DPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPG-AHILRRK 184
G + G + SVA + DG L G+++ E ++PLE G G H++ R+
Sbjct: 157 YVGDVAGLAEASSVALSNCDG--LAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRR 214
Query: 185 SPASGQ--GPMC-----------NVKAPLG----SPSPRPRRAKRFASLSRF-VETLVVA 226
P S GP ++ LG + RRA+R A+ + +E L+
Sbjct: 215 PPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGV 274
Query: 227 DDKMAAFHGAG-LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGP--QVGP 283
DD + FHG +++YLLT+M + + S+ +++V+ R+++L G+ ++G
Sbjct: 275 DDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIG- 333
Query: 284 SAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPAR 343
+ +Q+L + C W P+ ++ D AI TRQD G A V +C P R
Sbjct: 334 NPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDF---GPSGMQGYAPVTGMCHPVR 390
Query: 344 SCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEP 403
SC + +DG SAF AHE GHV M HD + G +MAP++
Sbjct: 391 SCTLNHEDGFSSAFVVAHETGHVLGMEHDGQG---NRCGDEVRLGSIMAPLVQAAFHRFH 447
Query: 404 WSPCSARFITDFLDNGYGHCLLDKPEAP--LHLPVTFPGKDYDADRQCQLTFGPDSRHCP 461
WS CS + ++ +L + CLLD P A LP PG Y + QC+ FG C
Sbjct: 448 WSRCSQQELSRYLHS--YDCLLDDPFAHDWPALP-QLPGLHYSMNEQCRFDFGLGYMMCT 504
Query: 462 QLP--PPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQ 499
PC LWCS H + C+TK P DGT C P +
Sbjct: 505 AFRTFDPCKQLWCS-HPDNPYFCKTKKGPPLDGTMCAPGK 543
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 135 bits (339), Expect = 2e-31
Identities = 102/309 (33%), Positives = 137/309 (44%), Gaps = 36/309 (11%)
Query: 523 WGPWGPWGDCSRTCGGGVQFSSRDCT----RPVPRNGGKYCEGRRTRFRSCNTEDCPTGS 578
WG W W CSR+CGGGV R C + VP G + C G R++ C ++CP
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 579 ALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQ-------CKLTCQAQALGYY 631
+FREEQC ++N ++ W P Y P D C L C G
Sbjct: 110 R-SFREEQCVSFNSHVYNGRTH----QWKPLY----PDDYVHISSKPCDLHCTTVD-GQR 159
Query: 632 YVLEPRVVDGTPCS-PDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSG 690
++ P DGT C D VCV G+C GCD ++ S DKC +C GDGS C+ +G
Sbjct: 160 QLMVP-ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTG 218
Query: 691 SFRK--FRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSP 748
++RK GY+ V IPAGA I + ++ LAL G Y NG Y + SP
Sbjct: 219 NYRKGNAHLGYSLVTHIPAGARDIQIVERKKSAD---VLALADEAGYYFFNGNYK-VDSP 274
Query: 749 TDVVLPGAVSLRYSGATAASET----LSGHGPLAQPLTLQVL-VAGNPQDTRLRYSFFVP 803
+ + G V ++Y ET + GP Q L + V G Y+ P
Sbjct: 275 KNFNIAGTV-VKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP 333
Query: 804 RPTPSTPRP 812
P S P+P
Sbjct: 334 -PHESRPQP 341
Score = 34.7 bits (78), Expect = 0.38
Identities = 23/89 (25%), Positives = 32/89 (35%), Gaps = 21/89 (23%)
Query: 466 PCAALWCSGHLNGHAMCQTKHSPWADGTPCGPA-------QACMGGRCLHMDQLQDFNIP 518
PC+A +G ++ +AMC D + C + C G C +
Sbjct: 575 PCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSS---- 630
Query: 519 QAGGWGPWGPWGDCSRTCGGGVQFSSRDC 547
W +CSRTCG G QF C
Sbjct: 631 ----------WSECSRTCGEGYQFRVVRC 649
Score = 32.0 bits (71), Expect = 2.4
Identities = 14/49 (28%), Positives = 24/49 (48%)
Query: 528 PWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPT 576
PW +C++TCG GV+ C + G + ++C+ + CPT
Sbjct: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPT 909
>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 135 bits (339), Expect = 2e-31
Identities = 102/309 (33%), Positives = 137/309 (44%), Gaps = 36/309 (11%)
Query: 523 WGPWGPWGDCSRTCGGGVQFSSRDCT----RPVPRNGGKYCEGRRTRFRSCNTEDCPTGS 578
WG W W CSR+CGGGV R C + VP G + C G R++ C ++CP
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 579 ALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQ-------CKLTCQAQALGYY 631
+FREEQC ++N ++ W P Y P D C L C G
Sbjct: 110 R-SFREEQCVSFNSHVYNGRTH----QWKPLY----PDDYVHISSKPCDLHCTTVD-GQR 159
Query: 632 YVLEPRVVDGTPCS-PDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSG 690
++ P DGT C D VCV G+C GCD ++ S DKC +C GDGS C+ +G
Sbjct: 160 QLMVP-ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTG 218
Query: 691 SFRK--FRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSP 748
++RK GY+ V IPAGA I + ++ LAL G Y NG Y + SP
Sbjct: 219 NYRKGNAHLGYSLVTHIPAGARDIQIVERKKSAD---VLALADEAGYYFFNGNYK-VDSP 274
Query: 749 TDVVLPGAVSLRYSGATAASET----LSGHGPLAQPLTLQVL-VAGNPQDTRLRYSFFVP 803
+ + G V ++Y ET + GP Q L + V G Y+ P
Sbjct: 275 KNFNIAGTV-VKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP 333
Query: 804 RPTPSTPRP 812
P S P+P
Sbjct: 334 -PHESRPQP 341
Score = 34.7 bits (78), Expect = 0.38
Identities = 23/89 (25%), Positives = 32/89 (35%), Gaps = 21/89 (23%)
Query: 466 PCAALWCSGHLNGHAMCQTKHSPWADGTPCGPA-------QACMGGRCLHMDQLQDFNIP 518
PC+A +G ++ +AMC D + C + C G C +
Sbjct: 575 PCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSS---- 630
Query: 519 QAGGWGPWGPWGDCSRTCGGGVQFSSRDC 547
W +CSRTCG G QF C
Sbjct: 631 ----------WSECSRTCGEGYQFRVVRC 649
Score = 32.0 bits (71), Expect = 2.4
Identities = 14/49 (28%), Positives = 24/49 (48%)
Query: 528 PWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPT 576
PW +C++TCG GV+ C + G + ++C+ + CPT
Sbjct: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPT 909
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.450
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,819,458
Number of Sequences: 37866
Number of extensions: 2345248
Number of successful extensions: 7348
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 81
Number of HSP's successfully gapped in prelim test: 58
Number of HSP's that attempted gapping in prelim test: 6561
Number of HSP's gapped (non-prelim): 529
length of query: 837
length of database: 18,247,518
effective HSP length: 111
effective length of query: 726
effective length of database: 14,044,392
effective search space: 10196228592
effective search space used: 10196228592
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.