Search of human proteins with 157384984

Search of human proteins with 157384984

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157384984 transducin-like enhancer protein 3 isoform c [Homo
sapiens]
         (760 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157384984 transducin-like enhancer protein 3 isoform c [Homo ...  1555   0.0  
gi|157384986 transducin-like enhancer protein 3 isoform b [Homo ...  1547   0.0  
gi|157384982 transducin-like enhancer protein 3 isoform a [Homo ...  1546   0.0  
gi|34915994 transducin-like enhancer protein 4 [Homo sapiens]        1266   0.0  
gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]        1230   0.0  
gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo s...   968   0.0  
gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo ...   837   0.0  
gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo ...   779   0.0  
gi|5706731 amino-terminal enhancer of split isoform b [Homo sapi...   231   1e-60
gi|39812027 amino-terminal enhancer of split isoform c [Homo sap...   229   7e-60
gi|39812019 amino-terminal enhancer of split isoform a [Homo sap...   226   5e-59
gi|221136834 transducin-like enhancer of split 6 isoform 1 [Homo...   199   1e-50
gi|13376099 transducin-like enhancer of split 6 isoform 2 [Homo ...   199   1e-50
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             89   2e-17
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             89   2e-17
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             89   2e-17
gi|26665869 WD repeat domain 51B [Homo sapiens]                        87   8e-17
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    84   5e-16
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is...    75   2e-13
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i...    75   2e-13
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...    74   5e-13
gi|8923881 WD SOCS-box protein 2 [Homo sapiens]                        74   7e-13
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     70   7e-12
gi|5174447 guanine nucleotide binding protein (G protein), beta ...    69   2e-11
gi|16554629 WD repeat domain 5 [Homo sapiens]                          69   2e-11
gi|16554627 WD repeat domain 5 [Homo sapiens]                          69   2e-11
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ...    69   2e-11
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     69   2e-11
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H...    68   4e-11
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     68   4e-11

>gi|157384984 transducin-like enhancer protein 3 isoform c [Homo
           sapiens]
          Length = 760

 Score = 1555 bits (4025), Expect = 0.0
 Identities = 760/760 (100%), Positives = 760/760 (100%)

Query: 1   MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH 60
           MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH
Sbjct: 1   MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH 60

Query: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN 120
           YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN
Sbjct: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN 120

Query: 121 AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTV 180
           AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTV
Sbjct: 121 AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTV 180

Query: 181 KDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDS 240
           KDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDS
Sbjct: 181 KDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDS 240

Query: 241 DGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSK 300
           DGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSK
Sbjct: 241 DGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSK 300

Query: 301 TKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPASALRTPISITSSYAAPFA 360
           TKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPASALRTPISITSSYAAPFA
Sbjct: 301 TKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPASALRTPISITSSYAAPFA 360

Query: 361 MMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGAVGFDPHPPMRAT 420
           MMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGAVGFDPHPPMRAT
Sbjct: 361 MMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGAVGFDPHPPMRAT 420

Query: 421 GLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAV 480
           GLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAV
Sbjct: 421 GLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAV 480

Query: 481 TISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGE 540
           TISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGE
Sbjct: 481 TISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGE 540

Query: 541 ASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVR 600
           ASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVR
Sbjct: 541 ASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVR 600

Query: 601 QFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGE 660
           QFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGE
Sbjct: 601 QFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGE 660

Query: 661 WLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYG 720
           WLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYG
Sbjct: 661 WLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYG 720

Query: 721 ASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 760
           ASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY
Sbjct: 721 ASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 760


>gi|157384986 transducin-like enhancer protein 3 isoform b [Homo
           sapiens]
          Length = 769

 Score = 1547 bits (4005), Expect = 0.0
 Identities = 760/769 (98%), Positives = 760/769 (98%), Gaps = 9/769 (1%)

Query: 1   MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH 60
           MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH
Sbjct: 1   MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH 60

Query: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN 120
           YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN
Sbjct: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN 120

Query: 121 AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTV 180
           AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTV
Sbjct: 121 AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTV 180

Query: 181 KDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDS 240
           KDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDS
Sbjct: 181 KDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDS 240

Query: 241 DGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSK 300
           DGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSK
Sbjct: 241 DGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSK 300

Query: 301 TKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMP---------ASALRTPISI 351
           TKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMP         ASALRTPISI
Sbjct: 301 TKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKPPGMDPIASALRTPISI 360

Query: 352 TSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGAVGF 411
           TSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGAVGF
Sbjct: 361 TSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGAVGF 420

Query: 412 DPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTL 471
           DPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTL
Sbjct: 421 DPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTL 480

Query: 472 SHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPD 531
           SHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPD
Sbjct: 481 SHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPD 540

Query: 532 GRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVW 591
           GRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVW
Sbjct: 541 GRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVW 600

Query: 592 DLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIF 651
           DLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIF
Sbjct: 601 DLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIF 660

Query: 652 SLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNL 711
           SLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNL
Sbjct: 661 SLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNL 720

Query: 712 LNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 760
           LNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY
Sbjct: 721 LNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 769


>gi|157384982 transducin-like enhancer protein 3 isoform a [Homo
           sapiens]
          Length = 772

 Score = 1546 bits (4002), Expect = 0.0
 Identities = 760/772 (98%), Positives = 760/772 (98%), Gaps = 12/772 (1%)

Query: 1   MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH 60
           MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH
Sbjct: 1   MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH 60

Query: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN 120
           YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN
Sbjct: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN 120

Query: 121 AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTV 180
           AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTV
Sbjct: 121 AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTV 180

Query: 181 KDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDS 240
           KDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDS
Sbjct: 181 KDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDS 240

Query: 241 DGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSK 300
           DGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSK
Sbjct: 241 DGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSK 300

Query: 301 TKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMP------------ASALRTP 348
           TKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMP            ASALRTP
Sbjct: 301 TKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKPPGMDPIGIMASALRTP 360

Query: 349 ISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGA 408
           ISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGA
Sbjct: 361 ISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGA 420

Query: 409 VGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQI 468
           VGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQI
Sbjct: 421 VGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQI 480

Query: 469 NTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKL 528
           NTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKL
Sbjct: 481 NTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKL 540

Query: 529 LPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNI 588
           LPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNI
Sbjct: 541 LPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNI 600

Query: 589 AVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTS 648
           AVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTS
Sbjct: 601 AVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTS 660

Query: 649 QIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGK 708
           QIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGK
Sbjct: 661 QIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGK 720

Query: 709 DNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 760
           DNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY
Sbjct: 721 DNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 772


>gi|34915994 transducin-like enhancer protein 4 [Homo sapiens]
          Length = 773

 Score = 1266 bits (3275), Expect = 0.0
 Identities = 633/775 (81%), Positives = 687/775 (88%), Gaps = 24/775 (3%)

Query: 1   MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH 60
           MYPQ RHPAPHQP QP FKFT++ESCDRIK+EFQFLQAQYHSLK+E +KLA+EKTEMQRH
Sbjct: 8   MYPQTRHPAPHQPAQP-FKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 66

Query: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN 120
           YVMYYEMSYGLNIEMHKQ EI KRLN I AQ++PFLSQEHQQQV QAVERAKQVTM ELN
Sbjct: 67  YVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELN 126

Query: 121 AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALG-ALGSQAHLT 179
           AIIGQQ LQAQHLSH  HG PV L PHPSGLQPP IPP+ GSS+GLLAL  ALG Q+HL 
Sbjct: 127 AIIGQQ-LQAQHLSHG-HGLPVPLTPHPSGLQPPAIPPI-GSSAGLLALSSALGGQSHLP 183

Query: 180 VKDEKNHHELDH-RERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRY 238
           +KDEK HH+ DH R+R+S  ++SVSPS S R +EKHR SADYS E+KK+K EEK+  +RY
Sbjct: 184 IKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARY 243

Query: 239 DSDGDKSDD-LVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTP 297
           DSDG+KSDD LVVDVSNEDP++PR SPAHSP ENGLDK R LKKDAP SPAS+ASSSSTP
Sbjct: 244 DSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKTRLLKKDAPISPASIASSSSTP 303

Query: 298 SSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMP---------ASALRTP 348
           SSK+K+L  N+KS+TP  KSNTPTPR DAPTPG+++TPGLR +P         AS+LRTP
Sbjct: 304 SSKSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKPPGVDPLASSLRTP 363

Query: 349 ISITSSYAAPFAMMSHHEMNGSLTSPGA-YAGLHNIPPQMSAAAAAAAAA--YGRSPMVS 405
           +++   Y  PF ++ H  MNG LTSPGA YAGLHNI PQMSAAAAAAAAA  YGRSP+V 
Sbjct: 364 MAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRSPVV- 422

Query: 406 FGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHA 465
               GFDPH  MR   +P +L  IPGGKPAYSFHVSADGQMQPVPFP DAL GPGIPRHA
Sbjct: 423 ----GFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHA 478

Query: 466 RQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRS 525
           RQINTL+HGEVVCAVTISNPTRHVYTGGKGCVK+WDIS PG+KSP+SQLDCLNRDNYIRS
Sbjct: 479 RQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRS 538

Query: 526 CKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSD 585
           C+LLPDGRTLIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALAISPD+KVCFSCCSD
Sbjct: 539 CRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSD 598

Query: 586 GNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHD 645
           GNIAVWDLHNQTLVRQFQGHTDGASCIDIS+DGTKLWTGGLDNTVRSWDLREGRQLQQHD
Sbjct: 599 GNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHD 658

Query: 646 FTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVS 705
           FTSQIFSLGYCPTGEWLAVGME+SNVEVLH TKPDKYQLHLHESCVLSLKFA+CGKWFVS
Sbjct: 659 FTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVS 718

Query: 706 TGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 760
           TGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS DDKYIVTGSGDKKATVYEVIY
Sbjct: 719 TGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 773


>gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]
          Length = 770

 Score = 1230 bits (3182), Expect = 0.0
 Identities = 615/778 (79%), Positives = 673/778 (86%), Gaps = 26/778 (3%)

Query: 1   MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH 60
           M+PQ RHP PHQ     FKFT+ ES DRIK+EFQFLQAQYHSLK+E +KLA+EKTEMQRH
Sbjct: 1   MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 60

Query: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN 120
           YVMYYEMSYGLNIEMHKQTEIAKRLNTI AQ++PFLSQEHQQQVAQAVERAKQVTM ELN
Sbjct: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELN 120

Query: 121 AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALG-ALGSQAHLT 179
           AIIGQQQLQAQHLSH  HGPPV L PHPSGLQPPGIPP+ G S+GLLAL  AL  Q+HL 
Sbjct: 121 AIIGQQQLQAQHLSHG-HGPPVPLTPHPSGLQPPGIPPL-GGSAGLLALSSALSGQSHLA 178

Query: 180 VKDEKNHHELDH-RERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRY 238
           +KD+K HH+ +H R+RE   +NS+   +SLR ++K R   ++S + KKRK ++KDS S Y
Sbjct: 179 IKDDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKDS-SHY 237

Query: 239 DSDGDKSDD-LVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTP 297
           DSDGDKSDD LVVDVSNEDP++PR SPAHSP ENG+DK R LKKDA +SPAS ASS+S+ 
Sbjct: 238 DSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASST 297

Query: 298 SSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLR-------------SMPASA 344
           S K+K++  ++K+STP LKS+TPTPR+D PTPGTS TPGLR             +  A+ 
Sbjct: 298 SLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAG 357

Query: 345 LRTPISITSSYAAPFAMMSHHEMNGSLTSPGA-YAGLHNIPPQMSAAAAAAAA-AYGRSP 402
           LRTP+++   Y APF M+ H  MNG LTSPGA YA LHN+ PQMSAAAAAAA  AYGRSP
Sbjct: 358 LRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVAYGRSP 417

Query: 403 MVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIP 462
           MV     GFDP P MR   +P +LA IPGGKPAYSFHV+ADGQMQPVPFP DAL GPGIP
Sbjct: 418 MV-----GFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIP 472

Query: 463 RHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNY 522
           RHARQINTL+HGEVVCAVTISNPTRHVYTGGKGCVK+WDIS PG+KSP+SQLDCLNRDNY
Sbjct: 473 RHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNY 532

Query: 523 IRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSC 582
           IRSCKLLPDG TLIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALAISPD+KVCFSC
Sbjct: 533 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 592

Query: 583 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQ 642
           CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDIS+DGTKLWTGGLDNTVRSWDLREGRQLQ
Sbjct: 593 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 652

Query: 643 QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKW 702
           QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLH  KPDKYQLHLHESCVLSLKFAYCGKW
Sbjct: 653 QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKW 712

Query: 703 FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 760
           FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS DDKYIVTGSGDKKATVYEVIY
Sbjct: 713 FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 770


>gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo
           sapiens]
          Length = 743

 Score =  968 bits (2502), Expect = 0.0
 Identities = 509/776 (65%), Positives = 597/776 (76%), Gaps = 49/776 (6%)

Query: 1   MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH 60
           MYPQGRHP P Q GQP FKF++ E CDRIK+EFQFLQAQYHSLK+E +KLA+EKTEMQRH
Sbjct: 1   MYPQGRHPTPLQSGQP-FKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 59

Query: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN 120
           YVMYYEMSYGLNIEMHKQ EI KRL+ I AQI+PFL+QEHQQQV QAVERAKQVT+ ELN
Sbjct: 60  YVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELN 119

Query: 121 AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLAL-GALGSQAHLT 179
           ++IGQQ    Q LSH  H PPV L P P+GL       V GS++GLLAL GAL +QA L 
Sbjct: 120 SLIGQQ---LQPLSH--HAPPVPLTPRPAGL-------VGGSATGLLALSGALAAQAQLA 167

Query: 180 --VKDEKNHHELDHR--ERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSL 235
             VK+++   E +    ER  S + S SP ESL   E+  G         K++A+EK+  
Sbjct: 168 AAVKEDRAGVEAEGSRVERAPSRSASPSPPESLVEEERPSGPGG----GGKQRADEKEPS 223

Query: 236 SRYDSDGDKSD-DLVVDVSN-EDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASS 293
             Y+SD DKSD +LVVD     +P +P  +P    P          ++D   SPAS+ASS
Sbjct: 224 GPYESDEDKSDYNLVVDEDQPSEPPSPATTPCGKVPI-----CIPARRDLVDSPASLASS 278

Query: 294 SSTPSSKTKDLGHND-KSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPAS--------A 344
             +P  + K+L  ND  +STP  KS   +P  DA TPG S+   L  + A         A
Sbjct: 279 LGSPLPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVA 338

Query: 345 LRTPISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMV 404
           LR+P++++S +   F++ SH  +NG L+ P +Y  LH + PQ+S++       YGRSP++
Sbjct: 339 LRSPLTLSSPFTTSFSLGSHSTLNGDLSVPSSYVSLH-LSPQVSSSVV-----YGRSPVM 392

Query: 405 SFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRH 464
           +F     + HP +R + + SSL SIPGGKPAYSFHVSADGQMQPVPFP DAL G GIPRH
Sbjct: 393 AF-----ESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRH 447

Query: 465 ARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIR 524
           ARQ++TL+HGEVVCAVTIS  T+HVYTGGKGCVK+WD+ QPG+K+P++QLDCLNRDNYIR
Sbjct: 448 ARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIR 507

Query: 525 SCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCS 584
           SCKLLPDGR+LIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALA+SPDAKVCFSCCS
Sbjct: 508 SCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCS 567

Query: 585 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQH 644
           DGNI VWDL NQT+VRQFQGHTDGASCIDIS  GT+LWTGGLDNTVR WDLREGRQLQQH
Sbjct: 568 DGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQH 627

Query: 645 DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFV 704
           DF+SQIFSLG+CP  +WLAVGMESSNVE+LH  KP+KYQLHLHESCVLSLKFA CG+WFV
Sbjct: 628 DFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRWFV 687

Query: 705 STGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 760
           STGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS ++KYIVTGSGDKKATVYEV+Y
Sbjct: 688 STGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY 743


>gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo
           sapiens]
          Length = 706

 Score =  837 bits (2163), Expect = 0.0
 Identities = 447/706 (63%), Positives = 531/706 (75%), Gaps = 48/706 (6%)

Query: 10  PHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSY 69
           P Q GQP FKF++ E CDRIK+EFQFLQAQYHSLK+E +KLA+EKTEMQRHYVMYYEMSY
Sbjct: 23  PLQSGQP-FKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSY 81

Query: 70  GLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGQQQLQ 129
           GLNIEMHKQ EI KRL+ I AQI+PFL+QEHQQQV QAVERAKQVT+ ELN++IGQQQLQ
Sbjct: 82  GLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQQLQ 141

Query: 130 AQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLAL-GALGSQAHLT--VKDEKNH 186
              LSH  H PPV L P P+GL       V GS++GLLAL GAL +QA L   VK+++  
Sbjct: 142 P--LSH--HAPPVPLTPRPAGL-------VGGSATGLLALSGALAAQAQLAAAVKEDRAG 190

Query: 187 HELDHR--ERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDK 244
            E +    ER  S + S SP ESL   E+  G         K++A+EK+    Y+SD DK
Sbjct: 191 VEAEGSRVERAPSRSASPSPPESLVEEERPSGPGG----GGKQRADEKEPSGPYESDEDK 246

Query: 245 SD-DLVVDVSN-EDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSKTK 302
           SD +LVVD     +P +P  +P    P          ++D   SPAS+ASS  +P  + K
Sbjct: 247 SDYNLVVDEDQPSEPPSPATTPCGKVPI-----CIPARRDLVDSPASLASSLGSPLPRAK 301

Query: 303 DLGHND-KSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPAS--------ALRTPISITS 353
           +L  ND  +STP  KS   +P  DA TPG S+   L  + A         ALR+P++++S
Sbjct: 302 ELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSS 361

Query: 354 SYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGAVGFDP 413
            +   F++ SH  +NG L+ P +Y  LH + PQ+S++       YGRSP+++F     + 
Sbjct: 362 PFTTSFSLGSHSTLNGDLSVPSSYVSLH-LSPQVSSSVV-----YGRSPVMAF-----ES 410

Query: 414 HPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSH 473
           HP +R + + SSL SIPGGKPAYSFHVSADGQMQPVPFP DAL G GIPRHARQ++TL+H
Sbjct: 411 HPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAH 470

Query: 474 GEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGR 533
           GEVVCAVTIS  T+HVYTGGKGCVK+WD+ QPG+K+P++QLDCLNRDNYIRSCKLLPDGR
Sbjct: 471 GEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGR 530

Query: 534 TLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDL 593
           +LIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALA+SPDAKVCFSCCSDGNI VWDL
Sbjct: 531 SLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDL 590

Query: 594 HNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSL 653
            NQT+VRQFQGHTDGASCIDIS  GT+LWTGGLDNTVR WDLREGRQLQQHDF+SQIFSL
Sbjct: 591 QNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSL 650

Query: 654 GYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYC 699
           G+CP  +WLAVGMESSNVE+LH  KP+KYQLHLHESCVLSLKFA C
Sbjct: 651 GHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASC 696



 Score = 30.0 bits (66), Expect = 8.3
 Identities = 29/148 (19%), Positives = 53/148 (35%), Gaps = 8/148 (5%)

Query: 617 DGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQI---FSLGYCPTGEWLAVGMESSNV-- 671
           DG  L  GG  +T+  WDL       + + TS     ++L   P  +         N+  
Sbjct: 528 DGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVV 587

Query: 672 -EVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESS 730
            ++ + T   ++Q H   +  + +       W  + G DN +  W    G  + Q   SS
Sbjct: 588 WDLQNQTMVRQFQGHTDGASCIDISDYGTRLW--TGGLDNTVRCWDLREGRQLQQHDFSS 645

Query: 731 SVLSCDISADDKYIVTGSGDKKATVYEV 758
            + S     +  ++  G       +  V
Sbjct: 646 QIFSLGHCPNQDWLAVGMESSNVEILHV 673


>gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo
           sapiens]
          Length = 621

 Score =  779 bits (2012), Expect = 0.0
 Identities = 423/709 (59%), Positives = 494/709 (69%), Gaps = 93/709 (13%)

Query: 57  MQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTM 116
           MQRHYVMYYEMSYGLNIEMHKQ EI KRL+ I AQI+PFL+QEHQQQV QAVERAKQVT+
Sbjct: 1   MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 60

Query: 117 TELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQA 176
            ELN++IG           A+  PP  L        P G                 G + 
Sbjct: 61  GELNSLIGS----------ASPSPPESLVEEERPSGPGG-----------------GGKQ 93

Query: 177 HLTVKDEKNHHELDHRERESSANNSV---SPSESLRASEKHRGSADYSMEAKKRKAEEKD 233
               K+    +E D  E +S  N  V    PSE    +    G     + A++       
Sbjct: 94  RADEKEPSGPYESD--EDKSDYNLVVDEDQPSEPPSPATTPCGKVPICIPARR------- 144

Query: 234 SLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSL-KKDAPTSPASVAS 292
                        DLV      D      S   SP    L +A+ L   D P        
Sbjct: 145 -------------DLV------DSPASLASSLGSP----LPRAKELILNDLP-------- 173

Query: 293 SSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDA-PTPGTSTTPGLRSMPASALRTPISI 351
            +STP+SK+ D      +STPG  S +   +  A P P T +          ALR+P+++
Sbjct: 174 -ASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSV---------ALRSPLTL 223

Query: 352 TSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGAVGF 411
           +S +   F++ SH  +NG L+ P +Y  LH + PQ+S     ++  YGRSP+++     F
Sbjct: 224 SSPFTTSFSLGSHSTLNGDLSVPSSYVSLH-LSPQVS-----SSVVYGRSPVMA-----F 272

Query: 412 DPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTL 471
           + HP +R + + SSL SIPGGKPAYSFHVSADGQMQPVPFP DAL G GIPRHARQ++TL
Sbjct: 273 ESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTL 332

Query: 472 SHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPD 531
           +HGEVVCAVTIS  T+HVYTGGKGCVK+WD+ QPG+K+P++QLDCLNRDNYIRSCKLLPD
Sbjct: 333 AHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 392

Query: 532 GRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVW 591
           GR+LIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALA+SPDAKVCFSCCSDGNI VW
Sbjct: 393 GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVW 452

Query: 592 DLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIF 651
           DL NQT+VRQFQGHTDGASCIDIS  GT+LWTGGLDNTVR WDLREGRQLQQHDF+SQIF
Sbjct: 453 DLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIF 512

Query: 652 SLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNL 711
           SLG+CP  +WLAVGMESSNVE+LH  KP+KYQLHLHESCVLSLKFA CG+WFVSTGKDNL
Sbjct: 513 SLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNL 572

Query: 712 LNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 760
           LNAWRTPYGASIFQSKESSSVLSCDIS ++KYIVTGSGDKKATVYEV+Y
Sbjct: 573 LNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY 621


>gi|5706731 amino-terminal enhancer of split isoform b [Homo
           sapiens]
          Length = 197

 Score =  231 bits (590), Expect = 1e-60
 Identities = 125/201 (62%), Positives = 151/201 (75%), Gaps = 6/201 (2%)

Query: 1   MYPQGRHP-APHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQR 59
           M+PQ RH  + H P Q   KFT ++SCDRIKDEFQ LQAQYHSLK+E DKLA+EK+EMQR
Sbjct: 2   MFPQSRHSGSSHLPQQ--LKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQR 59

Query: 60  HYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTEL 119
           HYVMYYEMSYGLNIEMHKQ EI KRLN I AQ++P+LSQEHQQQV  A+ERAKQVT  EL
Sbjct: 60  HYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPEL 119

Query: 120 NAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLT 179
           N+II +QQLQA  LS       + L P P GLQPP +P V+ + +GLL+L ALGSQAHL+
Sbjct: 120 NSII-RQQLQAHQLSQ-LQALALPLTPLPVGLQPPSLPAVS-AGTGLLSLSALGSQAHLS 176

Query: 180 VKDEKNHHELDHRERESSANN 200
            +D+  H    H+E +   ++
Sbjct: 177 KEDKNGHDGDTHQEDDGEKSD 197


>gi|39812027 amino-terminal enhancer of split isoform c [Homo
           sapiens]
          Length = 196

 Score =  229 bits (584), Expect = 7e-60
 Identities = 124/201 (61%), Positives = 150/201 (74%), Gaps = 7/201 (3%)

Query: 1   MYPQGRHP-APHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQR 59
           M+PQ RH  + H P Q   KFT ++SCDRIKDEFQ LQAQYHSLK+E DKLA+EK+EMQR
Sbjct: 2   MFPQSRHSGSSHLPQQ--LKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQR 59

Query: 60  HYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTEL 119
           HYVMYYEMSYGLNIEMHKQ EI KRLN I AQ++P+LSQEHQQQV  A+ERAKQVT  EL
Sbjct: 60  HYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPEL 119

Query: 120 NAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLT 179
           N+II  +QLQA  LS       + L P P GLQPP +P V+ + +GLL+L ALGSQAHL+
Sbjct: 120 NSII--RQLQAHQLSQ-LQALALPLTPLPVGLQPPSLPAVS-AGTGLLSLSALGSQAHLS 175

Query: 180 VKDEKNHHELDHRERESSANN 200
            +D+  H    H+E +   ++
Sbjct: 176 KEDKNGHDGDTHQEDDGEKSD 196


>gi|39812019 amino-terminal enhancer of split isoform a [Homo
           sapiens]
          Length = 264

 Score =  226 bits (577), Expect = 5e-59
 Identities = 122/198 (61%), Positives = 147/198 (74%), Gaps = 5/198 (2%)

Query: 3   PQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYV 62
           P G   + H P Q   KFT ++SCDRIKDEFQ LQAQYHSLK+E DKLA+EK+EMQRHYV
Sbjct: 72  PAGCRGSSHLPQQ--LKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYV 129

Query: 63  MYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAI 122
           MYYEMSYGLNIEMHKQ EI KRLN I AQ++P+LSQEHQQQV  A+ERAKQVT  ELN+I
Sbjct: 130 MYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSI 189

Query: 123 IGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTVKD 182
           I +QQLQA  LS       + L P P GLQPP +P V+ + +GLL+L ALGSQAHL+ +D
Sbjct: 190 I-RQQLQAHQLSQ-LQALALPLTPLPVGLQPPSLPAVS-AGTGLLSLSALGSQAHLSKED 246

Query: 183 EKNHHELDHRERESSANN 200
           +  H    H+E +   ++
Sbjct: 247 KNGHDGDTHQEDDGEKSD 264


>gi|221136834 transducin-like enhancer of split 6 isoform 1 [Homo
           sapiens]
          Length = 572

 Score =  199 bits (505), Expect = 1e-50
 Identities = 104/314 (33%), Positives = 181/314 (57%), Gaps = 10/314 (3%)

Query: 454 DALAGPG----IPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKS 509
           DAL G      +P    ++  L+HGE+V A  IS+ TRHV+T G+  +K+W ++   ++ 
Sbjct: 262 DALPGQSKRLAVPCKLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTGQVAED 321

Query: 510 --PISQLDCLNRDNYIRSCKLLPDGRTLIVGG-EASTLTIWDLASPTPRIKAELTSSAPA 566
             P S L       ++R+C L  + R+L+ GG   +++++WDLA+P+  +K +L  +   
Sbjct: 322 RFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLAAPSLHVKEQLPCAGLN 381

Query: 567 CYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGL 626
           C AL  + DA + F+  + G + +WDL +Q++VR  +G+ DG   I +   G  +WTGG 
Sbjct: 382 CQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVK--GYNIWTGGP 439

Query: 627 DNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHL 686
           D  +R WD R   +  ++ F SQI SL + P  +W+ +GM +    +   +   ++ +  
Sbjct: 440 DACLRCWDQRTIMKPLEYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVGQ 499

Query: 687 HESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVT 746
            +S +LS+KF+  G+W+ S G D+ L  +  P G  +F+  E S V  CD+S++++ +VT
Sbjct: 500 KDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMSPVTCCDVSSNNRLVVT 559

Query: 747 GSGDKKATVYEVIY 760
           GSG+  A+VY++ Y
Sbjct: 560 GSGE-HASVYQITY 572


>gi|13376099 transducin-like enhancer of split 6 isoform 2 [Homo
           sapiens]
          Length = 449

 Score =  199 bits (505), Expect = 1e-50
 Identities = 104/314 (33%), Positives = 181/314 (57%), Gaps = 10/314 (3%)

Query: 454 DALAGPG----IPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKS 509
           DAL G      +P    ++  L+HGE+V A  IS+ TRHV+T G+  +K+W ++   ++ 
Sbjct: 139 DALPGQSKRLAVPCKLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTGQVAED 198

Query: 510 --PISQLDCLNRDNYIRSCKLLPDGRTLIVGG-EASTLTIWDLASPTPRIKAELTSSAPA 566
             P S L       ++R+C L  + R+L+ GG   +++++WDLA+P+  +K +L  +   
Sbjct: 199 RFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLAAPSLHVKEQLPCAGLN 258

Query: 567 CYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGL 626
           C AL  + DA + F+  + G + +WDL +Q++VR  +G+ DG   I +   G  +WTGG 
Sbjct: 259 CQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVK--GYNIWTGGP 316

Query: 627 DNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHL 686
           D  +R WD R   +  ++ F SQI SL + P  +W+ +GM +    +   +   ++ +  
Sbjct: 317 DACLRCWDQRTIMKPLEYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVGQ 376

Query: 687 HESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVT 746
            +S +LS+KF+  G+W+ S G D+ L  +  P G  +F+  E S V  CD+S++++ +VT
Sbjct: 377 KDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMSPVTCCDVSSNNRLVVT 436

Query: 747 GSGDKKATVYEVIY 760
           GSG+  A+VY++ Y
Sbjct: 437 GSGE-HASVYQITY 449


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 60/259 (23%), Positives = 111/259 (42%), Gaps = 12/259 (4%)

Query: 465 ARQINTLSHGEVVCAVTISNPTRHVYTGGKG--CVKIWDISQPGSKSPISQLDCLNRDNY 522
           +R      H + V  V  S P+ H+   G     V+IW  +  G  +             
Sbjct: 14  SRAYRFTGHKDAVTCVNFS-PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT----- 67

Query: 523 IRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSC 582
           +RS     DG++ +   +  T+ +W  A+   +    L+           SPD ++  S 
Sbjct: 68  VRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSA 125

Query: 583 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQ 642
             D  + +WD  ++  V  +  H    + +D    GT +   G+DNTV+ WD+R  R LQ
Sbjct: 126 SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ 185

Query: 643 QHDF-TSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPD-KYQLHLHESCVLSLKFAYCG 700
            +   ++ +  L + P+G +L      S +++L   +    Y LH H+    ++ F+  G
Sbjct: 186 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 245

Query: 701 KWFVSTGKDNLLNAWRTPY 719
           ++F S G D  +  W++ +
Sbjct: 246 EYFASGGSDEQVMVWKSNF 264



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 36/133 (27%), Positives = 58/133 (43%), Gaps = 2/133 (1%)

Query: 585 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLR-EGRQLQQ 643
           D  + VW +  Q+   +F GH D  +C++ S  G  L +G  D TVR W    +G     
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 644 HDFTSQIFSLGYCPTGEWLAVGMESSNVEV-LHHTKPDKYQLHLHESCVLSLKFAYCGKW 702
              T+ + S+ +C  G+      +   V+V   H +   + L  H + V   KF+  G+ 
Sbjct: 62  RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121

Query: 703 FVSTGKDNLLNAW 715
            VS   D  +  W
Sbjct: 122 IVSASDDKTVKLW 134


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 60/259 (23%), Positives = 111/259 (42%), Gaps = 12/259 (4%)

Query: 465 ARQINTLSHGEVVCAVTISNPTRHVYTGGKG--CVKIWDISQPGSKSPISQLDCLNRDNY 522
           +R      H + V  V  S P+ H+   G     V+IW  +  G  +             
Sbjct: 52  SRAYRFTGHKDAVTCVNFS-PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT----- 105

Query: 523 IRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSC 582
           +RS     DG++ +   +  T+ +W  A+   +    L+           SPD ++  S 
Sbjct: 106 VRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSA 163

Query: 583 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQ 642
             D  + +WD  ++  V  +  H    + +D    GT +   G+DNTV+ WD+R  R LQ
Sbjct: 164 SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ 223

Query: 643 QHDF-TSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPD-KYQLHLHESCVLSLKFAYCG 700
            +   ++ +  L + P+G +L      S +++L   +    Y LH H+    ++ F+  G
Sbjct: 224 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283

Query: 701 KWFVSTGKDNLLNAWRTPY 719
           ++F S G D  +  W++ +
Sbjct: 284 EYFASGGSDEQVMVWKSNF 302



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 42/166 (25%), Positives = 78/166 (46%), Gaps = 7/166 (4%)

Query: 597 TLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQ---IFSL 653
           +L R F+GH D  +C+D S +  +L +G +D+ +  W ++   Q + + FT     +  +
Sbjct: 10  SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKP--QSRAYRFTGHKDAVTCV 67

Query: 654 GYCPTGEWLAVGMESSNVEV-LHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLL 712
            + P+G  LA G     V + + + K +      H + V S+ F   G+ FV+   D  +
Sbjct: 68  NFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTV 127

Query: 713 NAWRTPYGASIFQSKESSSVLSC-DISADDKYIVTGSGDKKATVYE 757
             W T     +F   +  + + C   S D + IV+ S DK   +++
Sbjct: 128 KVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 41/164 (25%), Positives = 67/164 (40%), Gaps = 2/164 (1%)

Query: 554 PRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCID 613
           P ++        A   +  S + K   S   D  + VW +  Q+   +F GH D  +C++
Sbjct: 9   PSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVN 68

Query: 614 ISHDGTKLWTGGLDNTVRSWDLR-EGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVE 672
            S  G  L +G  D TVR W    +G        T+ + S+ +C  G+      +   V+
Sbjct: 69  FSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128

Query: 673 V-LHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAW 715
           V   H +   + L  H + V   KF+  G+  VS   D  +  W
Sbjct: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 60/259 (23%), Positives = 111/259 (42%), Gaps = 12/259 (4%)

Query: 465 ARQINTLSHGEVVCAVTISNPTRHVYTGGKG--CVKIWDISQPGSKSPISQLDCLNRDNY 522
           +R      H + V  V  S P+ H+   G     V+IW  +  G  +             
Sbjct: 52  SRAYRFTGHKDAVTCVNFS-PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT----- 105

Query: 523 IRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSC 582
           +RS     DG++ +   +  T+ +W  A+   +    L+           SPD ++  S 
Sbjct: 106 VRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSA 163

Query: 583 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQ 642
             D  + +WD  ++  V  +  H    + +D    GT +   G+DNTV+ WD+R  R LQ
Sbjct: 164 SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ 223

Query: 643 QHDF-TSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPD-KYQLHLHESCVLSLKFAYCG 700
            +   ++ +  L + P+G +L      S +++L   +    Y LH H+    ++ F+  G
Sbjct: 224 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283

Query: 701 KWFVSTGKDNLLNAWRTPY 719
           ++F S G D  +  W++ +
Sbjct: 284 EYFASGGSDEQVMVWKSNF 302



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 42/166 (25%), Positives = 78/166 (46%), Gaps = 7/166 (4%)

Query: 597 TLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQ---IFSL 653
           +L R F+GH D  +C+D S +  +L +G +D+ +  W ++   Q + + FT     +  +
Sbjct: 10  SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKP--QSRAYRFTGHKDAVTCV 67

Query: 654 GYCPTGEWLAVGMESSNVEV-LHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLL 712
            + P+G  LA G     V + + + K +      H + V S+ F   G+ FV+   D  +
Sbjct: 68  NFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTV 127

Query: 713 NAWRTPYGASIFQSKESSSVLSC-DISADDKYIVTGSGDKKATVYE 757
             W T     +F   +  + + C   S D + IV+ S DK   +++
Sbjct: 128 KVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 41/164 (25%), Positives = 67/164 (40%), Gaps = 2/164 (1%)

Query: 554 PRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCID 613
           P ++        A   +  S + K   S   D  + VW +  Q+   +F GH D  +C++
Sbjct: 9   PSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVN 68

Query: 614 ISHDGTKLWTGGLDNTVRSWDLR-EGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVE 672
            S  G  L +G  D TVR W    +G        T+ + S+ +C  G+      +   V+
Sbjct: 69  FSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128

Query: 673 V-LHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAW 715
           V   H +   + L  H + V   KF+  G+  VS   D  +  W
Sbjct: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 86.7 bits (213), Expect = 8e-17
 Identities = 64/259 (24%), Positives = 108/259 (41%), Gaps = 10/259 (3%)

Query: 464 HARQINTLSHGEVVCAVTISNPTRHVYTGGKG-CVKIWDISQPGSKSPISQLDCLNRDNY 522
           HAR    + H +VV +V  S     + +  +   V++W    P  +   S+         
Sbjct: 50  HARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWI---PDKRGKFSEFKAHTAP-- 104

Query: 523 IRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSC 582
           +RS     DG+ L    E  ++ +W +     R    L            SPD ++  SC
Sbjct: 105 VRSVDFSADGQFLATASEDKSIKVWSMYRQ--RFLYSLYRHTHWVRCAKFSPDGRLIVSC 162

Query: 583 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQ 642
             D  I +WD  N+  V  F      A+ +D +  GT + + G D TV+ WD+R  + LQ
Sbjct: 163 SEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQ 222

Query: 643 QHDFTS-QIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDK-YQLHLHESCVLSLKFAYCG 700
            +   S  +  + + P+G +L        +++L   +    Y L  H   V ++ F+  G
Sbjct: 223 HYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGG 282

Query: 701 KWFVSTGKDNLLNAWRTPY 719
           + F S G D  +  WRT +
Sbjct: 283 ELFASGGADTQVLLWRTNF 301



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 46/212 (21%), Positives = 88/212 (41%), Gaps = 3/212 (1%)

Query: 550 ASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGA 609
           A+  P ++        A  +L +SP+ K   +   D  + +W+        ++ GH D  
Sbjct: 4   ATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVV 63

Query: 610 SCIDISHDGTKLWTGGLDNTVRSW-DLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMES 668
           + +  S  G  L +   D TVR W   + G+  +    T+ + S+ +   G++LA   E 
Sbjct: 64  TSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASED 123

Query: 669 SNVEVLH-HTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSK 727
            +++V   + +   Y L+ H   V   KF+  G+  VS  +D  +  W T     +    
Sbjct: 124 KSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS 183

Query: 728 ESSSVLS-CDISADDKYIVTGSGDKKATVYEV 758
           +S    +  D +     I +   D+   V++V
Sbjct: 184 DSVGFANFVDFNPSGTCIASAGSDQTVKVWDV 215


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 67/262 (25%), Positives = 110/262 (41%), Gaps = 16/262 (6%)

Query: 508 KSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPAC 567
           ++PI  L     +  +  CK  P+G TL   G    + +W++        A L   + A 
Sbjct: 56  QAPIMLLS--GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNY-ATLKGHSGAV 112

Query: 568 YALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGA-SCIDISHDGTKLWTGGL 626
             L  + D  + FS  +D  +AVWD      V++ +GHT    SC         + TG  
Sbjct: 113 MELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSD 172

Query: 627 DNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEV--LHHTKPDKYQL 684
           D TV+ WD+R+   +Q    T Q+ ++ +  T + +  G   ++++V  L   K   Y +
Sbjct: 173 DGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKL-TYTM 231

Query: 685 HLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRT-PYG-----ASIFQSKE---SSSVLSC 735
             H   V  L  +  G + +S   DN +  W   P+        IFQ        ++L C
Sbjct: 232 RGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC 291

Query: 736 DISADDKYIVTGSGDKKATVYE 757
             S D   I  GS D+   V++
Sbjct: 292 SWSPDGSKIAAGSADRFVYVWD 313



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 57/229 (24%), Positives = 96/229 (41%), Gaps = 23/229 (10%)

Query: 497 VKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLI-VGGEASTLTIWDLASPTPR 555
           V +WD S+ G +  + +L      +++ SC     G  L+  G +  T+ +WD+     R
Sbjct: 133 VAVWD-SETGER--VKRLK--GHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI-----R 182

Query: 556 IKAELTSSAPACYALAIS--PDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCID 613
            KA + +       LA++    +    S   D +I VWDL    L    +GH D  + + 
Sbjct: 183 KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242

Query: 614 ISHDGTKLWTGGLDNTVRSWDLREGRQLQQ---------HDFTSQIFSLGYCPTGEWLAV 664
           +S +G+ L +  +DNTVR WD+R     ++         H+F   +    + P G  +A 
Sbjct: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302

Query: 665 GMESSNVEVLHHT-KPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLL 712
           G     V V   T +   Y+L  H   +  + F       +S   D  L
Sbjct: 303 GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351


>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
           isoform a [Homo sapiens]
          Length = 353

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 68/299 (22%), Positives = 123/299 (41%), Gaps = 23/299 (7%)

Query: 473 HG-EVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPD 531
           HG +V+C     +  R V +   G V +WD S   +K     + C     ++ +C   P 
Sbjct: 62  HGNKVLCMDWCKDKRRIVSSSQDGKVIVWD-SFTTNKEHAVTMPC----TWVMACAYAPS 116

Query: 532 GRTLIVGGEASTLTIWDLA-------SPTPRIKAELTSSAPACYALAISPDAKVCFSCCS 584
           G  +  GG  +  +++ L        +   +  A  T+   AC   + +       +   
Sbjct: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSAC---SFTNSDMQILTASG 173

Query: 585 DGNIAVWDLHNQTLVRQFQGHTDGASCIDI--SHDGTKLWTGGLDNTVRSWDLREGRQLQ 642
           DG  A+WD+ +  L++ F GH     C+D+  S  G    +GG D     WD+R G+ +Q
Sbjct: 174 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ 233

Query: 643 QHD-FTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVL---SLKFAY 698
             +   S I S+ Y P+G+  A G + +   +       +  ++  ES +    S+ F+ 
Sbjct: 234 AFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSL 293

Query: 699 CGKWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISADDKYIVTGSGDKKATVY 756
            G+   +   D  +N W    G+ +       + V +  +S D     +GS D    V+
Sbjct: 294 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 36/173 (20%), Positives = 67/173 (38%), Gaps = 17/173 (9%)

Query: 600 RQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFT---SQIFSLGYC 656
           R  +GH +   C+D   D  ++ +   D  V  WD       ++H  T   + + +  Y 
Sbjct: 57  RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD--SFTTNKEHAVTMPCTWVMACAYA 114

Query: 657 PTGEWLAVGMESSNVEVL-------HHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKD 709
           P+G  +A G   +   V         +    K  + +H + + +  F       ++   D
Sbjct: 115 PSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGD 174

Query: 710 NLLNAWRTPYGASIFQS--KESSSVLSCDISADD--KYIVTGSGDKKATVYEV 758
                W    G  + QS     + VL  D++  +     V+G  DKKA V+++
Sbjct: 175 GTCALWDVESG-QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDM 226


>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
           isoform b [Homo sapiens]
          Length = 395

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 68/299 (22%), Positives = 123/299 (41%), Gaps = 23/299 (7%)

Query: 473 HG-EVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPD 531
           HG +V+C     +  R V +   G V +WD S   +K     + C     ++ +C   P 
Sbjct: 104 HGNKVLCMDWCKDKRRIVSSSQDGKVIVWD-SFTTNKEHAVTMPC----TWVMACAYAPS 158

Query: 532 GRTLIVGGEASTLTIWDLA-------SPTPRIKAELTSSAPACYALAISPDAKVCFSCCS 584
           G  +  GG  +  +++ L        +   +  A  T+   AC   + +       +   
Sbjct: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSAC---SFTNSDMQILTASG 215

Query: 585 DGNIAVWDLHNQTLVRQFQGHTDGASCIDI--SHDGTKLWTGGLDNTVRSWDLREGRQLQ 642
           DG  A+WD+ +  L++ F GH     C+D+  S  G    +GG D     WD+R G+ +Q
Sbjct: 216 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ 275

Query: 643 QHD-FTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVL---SLKFAY 698
             +   S I S+ Y P+G+  A G + +   +       +  ++  ES +    S+ F+ 
Sbjct: 276 AFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSL 335

Query: 699 CGKWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISADDKYIVTGSGDKKATVY 756
            G+   +   D  +N W    G+ +       + V +  +S D     +GS D    V+
Sbjct: 336 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 36/173 (20%), Positives = 67/173 (38%), Gaps = 17/173 (9%)

Query: 600 RQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFT---SQIFSLGYC 656
           R  +GH +   C+D   D  ++ +   D  V  WD       ++H  T   + + +  Y 
Sbjct: 99  RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD--SFTTNKEHAVTMPCTWVMACAYA 156

Query: 657 PTGEWLAVGMESSNVEVL-------HHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKD 709
           P+G  +A G   +   V         +    K  + +H + + +  F       ++   D
Sbjct: 157 PSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGD 216

Query: 710 NLLNAWRTPYGASIFQS--KESSSVLSCDISADD--KYIVTGSGDKKATVYEV 758
                W    G  + QS     + VL  D++  +     V+G  DKKA V+++
Sbjct: 217 GTCALWDVESG-QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDM 268


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 57/213 (26%), Positives = 92/213 (43%), Gaps = 6/213 (2%)

Query: 543 TLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQF 602
           ++ +W L S  P   A++         +   P  +   + C D +  +WDL  Q  +   
Sbjct: 304 SVKLWSLDSDEP--VADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQ 361

Query: 603 QGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQ-QHDFTSQIFSLGYCPTGEW 661
           +GH+ G   I    DG+   TGGLD   R WDLR GR +        +I+ + + P G  
Sbjct: 362 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYH 421

Query: 662 LAVGMESSNVEVLH-HTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGK-DNLLNAWRTPY 719
           +A G   +  +V     +   Y +  H++ V  +KF      F+ TG  DN    W  P 
Sbjct: 422 IATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPG 481

Query: 720 GASI-FQSKESSSVLSCDISADDKYIVTGSGDK 751
            + +   +     V+  DIS+D + I T S D+
Sbjct: 482 WSPLKTLAGHEGKVMGLDISSDGQLIATCSYDR 514



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 50/248 (20%), Positives = 78/248 (31%), Gaps = 51/248 (20%)

Query: 520 DNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVC 579
           D  I  C   P+ + L     +    +W +  P   +   L        A+   P + V 
Sbjct: 231 DRPISYCHFSPNSKMLATACWSGLCKLWSV--PDCNLLHTLRGHNTNVGAIVFHPKSTVS 288

Query: 580 F--------SCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVR 631
                    SC +DG++ +W L +   V   +GHT   + +     G  L T   D + R
Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348

Query: 632 SWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCV 691
            WDL                                 +  E+LH           H   V
Sbjct: 349 LWDLE--------------------------------AQEEILHQEG--------HSMGV 368

Query: 692 LSLKFAYCGKWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISADDKYIVTGSGD 750
             + F   G    + G D     W    G  I F       +   + S +  +I TGSGD
Sbjct: 369 YDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGD 428

Query: 751 KKATVYEV 758
               V+++
Sbjct: 429 NTCKVWDL 436



 Score = 30.0 bits (66), Expect = 8.3
 Identities = 22/105 (20%), Positives = 37/105 (35%), Gaps = 3/105 (2%)

Query: 530 PDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISP-DAKVCFSCCSDGNI 588
           P+G  +  G   +T  +WDL     R    + +       +   P       +   D   
Sbjct: 417 PNGYHIATGSGDNTCKVWDLRQR--RCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTA 474

Query: 589 AVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSW 633
            +W     + ++   GH      +DIS DG  + T   D T + W
Sbjct: 475 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519


>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
          Length = 404

 Score = 73.6 bits (179), Expect = 7e-13
 Identities = 61/259 (23%), Positives = 99/259 (38%), Gaps = 40/259 (15%)

Query: 495 GCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEAS-TLTIWDLASPT 553
           G +KIW++     ++ +  L+     + +R     P G  ++V      TL IWDL    
Sbjct: 133 GQIKIWEV-----QTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHG 187

Query: 554 PRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCID 613
            +I+  L+      Y  +ISPD  +  S   + ++ +W + + TL+R+ +GH       D
Sbjct: 188 KQIQV-LSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCD 246

Query: 614 ISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEV 673
            S D   L T   D  V  WD   G +L+                               
Sbjct: 247 FSPDSALLVTASYDTNVIMWDPYTGERLRS------------------------------ 276

Query: 674 LHHTK--PDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSS 731
           LHHT+  P      +H S + S+ F+  G +  +   D LL  W       I  +  ++ 
Sbjct: 277 LHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNG 336

Query: 732 VLSCDISADDKYIVTGSGD 750
            L C        I TG+ D
Sbjct: 337 -LCCTFFPHGGVIATGTRD 354



 Score = 37.7 bits (86), Expect = 0.040
 Identities = 41/164 (25%), Positives = 67/164 (40%), Gaps = 12/164 (7%)

Query: 584 SDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTK-LWTGGLDNTVRSWDL-REGRQL 641
           +DG I +W++    L+    GH D    +  +  G+  L +   D T+R WDL + G+Q+
Sbjct: 131 NDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQI 190

Query: 642 QQHDFTSQ-IFSLGYCPTGEWLAVGMESSNV---EVLHHTKPDKYQLHLHESCVLSLKFA 697
           Q      Q ++     P    L       +V    +  +T   K  L  H+S V+S  F+
Sbjct: 191 QVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRK--LEGHQSSVVSCDFS 248

Query: 698 YCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADD 741
                 V+   D  +  W  PY     +S   + V   D + DD
Sbjct: 249 PDSALLVTASYDTNVIMW-DPYTGERLRSLHHTQV---DPAMDD 288


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 45/191 (23%), Positives = 90/191 (47%), Gaps = 10/191 (5%)

Query: 456 LAGPGIPRHARQINTL-SHGEVVCAVTISNPT-RHVYTGGKGC-VKIWDISQPGSKSPIS 512
           +A P + + A ++  + +H   V ++ +   + R + TGG  C V +W I++P     ++
Sbjct: 1   MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLT 60

Query: 513 QLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAI 572
                   + + S +L      ++ G ++ ++ +WDL +   +I   L        +L  
Sbjct: 61  -----GHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAA--KILRTLMGHKANICSLDF 113

Query: 573 SPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRS 632
            P  +   S   D NI +WD+  +  V +++GH+    C+  S DG  L +   D+TV+ 
Sbjct: 114 HPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKL 173

Query: 633 WDLREGRQLQQ 643
           WDL  G+ + +
Sbjct: 174 WDLTAGKMMSE 184



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 43/173 (24%), Positives = 72/173 (41%), Gaps = 22/173 (12%)

Query: 473 HGEVVCAVTISNPTRHVYTGGK-GCVKIWDISQP-------GSKSPISQLDCLNRDNYIR 524
           H   V +V ++ P   +  G + G +++WD+          G K+ I  LD         
Sbjct: 62  HTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLD--------- 112

Query: 525 SCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCS 584
                P G  +  G + + + +WD+       +    S A  C  L  SPD K   S   
Sbjct: 113 ---FHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC--LRFSPDGKWLASAAD 167

Query: 585 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLRE 637
           D  + +WDL    ++ +F GHT   + ++   +   L +G  D T+R WDL +
Sbjct: 168 DHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 36/177 (20%), Positives = 76/177 (42%), Gaps = 3/177 (1%)

Query: 585 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQ- 643
           D  + +W ++    +    GHT     + ++     +  G    ++R WDL   + L+  
Sbjct: 42  DCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTL 101

Query: 644 HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLH-HTKPDKYQLHLHESCVLSLKFAYCGKW 702
               + I SL + P GE++A G + +N+++     K   ++   H   V  L+F+  GKW
Sbjct: 102 MGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKW 161

Query: 703 FVSTGKDNLLNAWRTPYGASIFQ-SKESSSVLSCDISADDKYIVTGSGDKKATVYEV 758
             S   D+ +  W    G  + +    +  V   +   ++  + +GS D+    +++
Sbjct: 162 LASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 38/170 (22%), Positives = 69/170 (40%), Gaps = 17/170 (10%)

Query: 471 LSHGEVVCAVTISNPTRHVYTGGKGC-VKIWDISQPGSKSPISQLDCLNR----DNYIRS 525
           + H   +C++        V +G +   +K+WDI + G         C+ R       +R 
Sbjct: 102 MGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG---------CVFRYRGHSQAVRC 152

Query: 526 CKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSD 585
            +  PDG+ L    +  T+ +WDL +   ++ +E          +   P+  +  S  SD
Sbjct: 153 LRFSPDGKWLASAADDHTVKLWDLTAG--KMMSEFPGHTGPVNVVEFHPNEYLLASGSSD 210

Query: 586 GNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDN-TVRSWD 634
             I  WDL    +V   +G       +  + DG  L++G  D+  V  W+
Sbjct: 211 RTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWE 260


>gi|5174447 guanine nucleotide binding protein (G protein), beta
           polypeptide 2-like 1 [Homo sapiens]
          Length = 317

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 52/205 (25%), Positives = 86/205 (41%), Gaps = 11/205 (5%)

Query: 460 GIPRHARQINTLSHGEVVCAVTISNPTRHVYTGG-KGCVKIWDISQPGSKSPISQLDCLN 518
           GIP+ A +     H   V  V IS+  +   +G   G +++WD++   +         + 
Sbjct: 53  GIPQRALR----GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRF-----VG 103

Query: 519 RDNYIRSCKLLPDGRTLIVGGEASTLTIWD-LASPTPRIKAELTSSAPACYALAISPDAK 577
               + S     D R ++ G    T+ +W+ L      ++ E  S   +C   + +    
Sbjct: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNP 163

Query: 578 VCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLRE 637
           +  SC  D  + VW+L N  L     GHT   + + +S DG+   +GG D     WDL E
Sbjct: 164 IIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE 223

Query: 638 GRQLQQHDFTSQIFSLGYCPTGEWL 662
           G+ L   D    I +L + P   WL
Sbjct: 224 GKHLYTLDGGDIINALCFSPNRYWL 248



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 45/180 (25%), Positives = 72/180 (40%), Gaps = 23/180 (12%)

Query: 472 SHGEVVCAVTISNPTRH---VYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKL 528
           SH E V  V  S  + +   V  G    VK+W+++    K+     + +    Y+ +  +
Sbjct: 146 SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT-----NHIGHTGYLNTVTV 200

Query: 529 LPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDG-N 587
            PDG     GG+     +WDL         +         AL  SP+    + C + G +
Sbjct: 201 SPDGSLCASGGKDGQAMLWDLNEGKHLYTLD---GGDIINALCFSPNRY--WLCAATGPS 255

Query: 588 IAVWDLHNQTLVRQFQGHTDGAS-------CIDI--SHDGTKLWTGGLDNTVRSWDLREG 638
           I +WDL  + +V + +      S       C  +  S DG  L+ G  DN VR W +  G
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 56/264 (21%), Positives = 104/264 (39%), Gaps = 14/264 (5%)

Query: 459 PGIPRHARQINTLSHGEVVCAVTIS-NPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCL 517
           P  P +A +     H + V +V  S N      +     +KIW       +  IS     
Sbjct: 30  PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS----- 84

Query: 518 NRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAK 577
                I       D   L+   +  TL IWD++S   +    L   +   +    +P + 
Sbjct: 85  GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSN 142

Query: 578 VCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLRE 637
           +  S   D ++ +WD+     ++    H+D  S +  + DG+ + +   D   R WD   
Sbjct: 143 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202

Query: 638 GRQLQQ--HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPD---KYQLHLHESCVL 692
           G+ L+    D    +  + + P G+++      + +++  ++K      Y  H +E   +
Sbjct: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262

Query: 693 SLKFAYCG-KWFVSTGKDNLLNAW 715
              F+  G KW VS  +DNL+  W
Sbjct: 263 FANFSVTGGKWIVSGSEDNLVYIW 286



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 46/210 (21%), Positives = 82/210 (39%), Gaps = 4/210 (1%)

Query: 552 PTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASC 611
           P   +K  L     A  ++  SP+ +   S  +D  I +W  ++    +   GH  G S 
Sbjct: 33  PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 92

Query: 612 IDISHDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSN 670
           +  S D   L +   D T++ WD+  G+ L+     ++ +F   + P    +  G    +
Sbjct: 93  VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152

Query: 671 VEVLH-HTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASI--FQSK 727
           V +    T      L  H   V ++ F   G   VS+  D L   W T  G  +      
Sbjct: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212

Query: 728 ESSSVLSCDISADDKYIVTGSGDKKATVYE 757
           ++  V     S + KYI+  + D    +++
Sbjct: 213 DNPPVSFVKFSPNGKYILAATLDNTLKLWD 242



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 46/193 (23%), Positives = 74/193 (38%), Gaps = 26/193 (13%)

Query: 484 NPTRHVYTGGK--GCVKIWDISQ-------PGSKSPISQLDCLNRDNYIRSCKLLPDGRT 534
           NP  ++   G     V+IWD+         P    P+S +   NRD           G  
Sbjct: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH-FNRD-----------GSL 185

Query: 535 LIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLH 594
           ++         IWD AS    +K  +    P    +  SP+ K   +   D  + +WD  
Sbjct: 186 IVSSSYDGLCRIWDTASGQC-LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244

Query: 595 NQTLVRQFQGHTDGASCI--DISHDGTK-LWTGGLDNTVRSWDLREGRQLQQ-HDFTSQI 650
               ++ + GH +   CI  + S  G K + +G  DN V  W+L+    +Q+    T  +
Sbjct: 245 KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304

Query: 651 FSLGYCPTGEWLA 663
            S    PT   +A
Sbjct: 305 ISTACHPTENIIA 317


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 56/264 (21%), Positives = 104/264 (39%), Gaps = 14/264 (5%)

Query: 459 PGIPRHARQINTLSHGEVVCAVTIS-NPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCL 517
           P  P +A +     H + V +V  S N      +     +KIW       +  IS     
Sbjct: 30  PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS----- 84

Query: 518 NRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAK 577
                I       D   L+   +  TL IWD++S   +    L   +   +    +P + 
Sbjct: 85  GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSN 142

Query: 578 VCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLRE 637
           +  S   D ++ +WD+     ++    H+D  S +  + DG+ + +   D   R WD   
Sbjct: 143 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202

Query: 638 GRQLQQ--HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPD---KYQLHLHESCVL 692
           G+ L+    D    +  + + P G+++      + +++  ++K      Y  H +E   +
Sbjct: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262

Query: 693 SLKFAYCG-KWFVSTGKDNLLNAW 715
              F+  G KW VS  +DNL+  W
Sbjct: 263 FANFSVTGGKWIVSGSEDNLVYIW 286



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 46/210 (21%), Positives = 82/210 (39%), Gaps = 4/210 (1%)

Query: 552 PTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASC 611
           P   +K  L     A  ++  SP+ +   S  +D  I +W  ++    +   GH  G S 
Sbjct: 33  PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 92

Query: 612 IDISHDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSN 670
           +  S D   L +   D T++ WD+  G+ L+     ++ +F   + P    +  G    +
Sbjct: 93  VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152

Query: 671 VEVLH-HTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASI--FQSK 727
           V +    T      L  H   V ++ F   G   VS+  D L   W T  G  +      
Sbjct: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212

Query: 728 ESSSVLSCDISADDKYIVTGSGDKKATVYE 757
           ++  V     S + KYI+  + D    +++
Sbjct: 213 DNPPVSFVKFSPNGKYILAATLDNTLKLWD 242



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 46/193 (23%), Positives = 74/193 (38%), Gaps = 26/193 (13%)

Query: 484 NPTRHVYTGGK--GCVKIWDISQ-------PGSKSPISQLDCLNRDNYIRSCKLLPDGRT 534
           NP  ++   G     V+IWD+         P    P+S +   NRD           G  
Sbjct: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH-FNRD-----------GSL 185

Query: 535 LIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLH 594
           ++         IWD AS    +K  +    P    +  SP+ K   +   D  + +WD  
Sbjct: 186 IVSSSYDGLCRIWDTASGQC-LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244

Query: 595 NQTLVRQFQGHTDGASCI--DISHDGTK-LWTGGLDNTVRSWDLREGRQLQQ-HDFTSQI 650
               ++ + GH +   CI  + S  G K + +G  DN V  W+L+    +Q+    T  +
Sbjct: 245 KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304

Query: 651 FSLGYCPTGEWLA 663
            S    PT   +A
Sbjct: 305 ISTACHPTENIIA 317


>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
           sapiens]
          Length = 421

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 61/257 (23%), Positives = 97/257 (37%), Gaps = 35/257 (13%)

Query: 495 GCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEAS-TLTIWDLASPT 553
           G +KIWD+      +    L+ ++    +R     PDG  ++V      TL +WDL    
Sbjct: 150 GRIKIWDVY-----TGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDG 204

Query: 554 PRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCID 613
             +K  L       Y+ A SPD+ +  S  +   + +W++   T++R+ +GH       D
Sbjct: 205 NMMKV-LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACD 263

Query: 614 ISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEV 673
            S DG  L T   D  V  WD   G  L +       F   + P     A G        
Sbjct: 264 FSPDGALLATASYDTRVYIWDPHNGDILME-------FGHLFPPPTPIFAGG-------- 308

Query: 674 LHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVL 733
                        ++  V S+ F++ G    S   D ++  WR      + Q    S+ L
Sbjct: 309 ------------ANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPLSNGL 355

Query: 734 SCDISADDKYIVTGSGD 750
            C  S D   +  G+ D
Sbjct: 356 CCAFSTDGSVLAAGTHD 372



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 49/220 (22%), Positives = 86/220 (39%), Gaps = 24/220 (10%)

Query: 468 INTLSHGEVVCAVTISNPTRHVYTGGKG--CVKIWDISQPGSKSPISQLDCLNRDNYIRS 525
           +N + H EVV  +T +     +         +++WD+   G+   + +       N++ S
Sbjct: 164 LNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLR----GHQNWVYS 219

Query: 526 CKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSD 585
           C   PD   L   G +  + +W++   T   K E         A   SPD  +  +   D
Sbjct: 220 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE--GHHHDVVACDFSPDGALLATASYD 277

Query: 586 GNIAVWDLHNQTLVRQFQGH---------TDGAS-----CIDISHDGTKLWTGGLDNTVR 631
             + +WD HN  ++ +F GH           GA+      +  SHDG  + +   D  VR
Sbjct: 278 TRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVR 336

Query: 632 SWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNV 671
            W + E   +Q    ++ +    +   G  LA G    +V
Sbjct: 337 FWRIDEDYPVQVAPLSNGL-CCAFSTDGSVLAAGTHDGSV 375



 Score = 38.1 bits (87), Expect = 0.031
 Identities = 31/139 (22%), Positives = 59/139 (42%), Gaps = 10/139 (7%)

Query: 584 SDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTK-LWTGGLDNTVRSWDLREGRQLQ 642
           ++G I +WD++   L+     HT+    +  + DG+  L +   D T+R WDL++   + 
Sbjct: 148 NNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMM 207

Query: 643 Q--HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKY----QLHLHESCVLSLKF 696
           +      + ++S  + P    L     S  V + +    DKY    +L  H   V++  F
Sbjct: 208 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWN---MDKYTMIRKLEGHHHDVVACDF 264

Query: 697 AYCGKWFVSTGKDNLLNAW 715
           +  G    +   D  +  W
Sbjct: 265 SPDGALLATASYDTRVYIW 283


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 64/289 (22%), Positives = 107/289 (37%), Gaps = 37/289 (12%)

Query: 505 PGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAE----- 559
           P S + I      N +  + + ++ PD + L  G + S + +W L S   ++K+E     
Sbjct: 253 PPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRS--KKLKSEPHQVD 310

Query: 560 ---------------------------LTSSAPACYALAISPDAKVCFSCCSDGNIAVWD 592
                                      L       Y+     D+    SC  D +I  WD
Sbjct: 311 VSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWD 370

Query: 593 LHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQH-DFTSQIF 651
           L + T    +QGH      +DIS       +G  D T R W       L+ +    + + 
Sbjct: 371 LGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVD 430

Query: 652 SLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHL-HESCVLSLKFAYCGKWFVSTGKDN 710
            + + P   +LA G     V +    + +  +L   H   VLSL F+  GK+  S G+D 
Sbjct: 431 CVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ 490

Query: 711 LLNAWRTPYGASIFQSK-ESSSVLSCDISADDKYIVTGSGDKKATVYEV 758
            L  W    G    + +  + ++ S   S D   I + S D    V+++
Sbjct: 491 RLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 61/241 (25%), Positives = 95/241 (39%), Gaps = 20/241 (8%)

Query: 523 IRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSC 582
           + S + L D   L+   E  ++  WDL S T  +  +    A   + L ISP +    S 
Sbjct: 345 VYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQ--GHAYPVWDLDISPYSLYFASG 402

Query: 583 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQ 642
             D    +W       +R + GH     C+    +   L TG  D TVR W  ++G  ++
Sbjct: 403 SHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVR 462

Query: 643 QHDFTSQ---IFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKY-QLHLHESCVLSLKFAY 698
              FT     + SL + P G++LA   E   +++        Y +L  H   + SL F+ 
Sbjct: 463 L--FTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSP 520

Query: 699 CGKWFVSTGKDNLLNAW--RTPYGASIFQSKES----------SSVLSCDISADDKYIVT 746
                 S   DN +  W  R  Y ++      S          S+VLS    A +  +VT
Sbjct: 521 DSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVT 580

Query: 747 G 747
           G
Sbjct: 581 G 581


>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
           sapiens]
          Length = 340

 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 59/249 (23%), Positives = 98/249 (39%), Gaps = 28/249 (11%)

Query: 519 RDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKV 578
           R +++ +C   P G  +  GG  +  +I++L S    +K     SA   Y          
Sbjct: 96  RSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGY---------- 145

Query: 579 CFSCC---SDGNI---------AVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGL 626
             SCC    D NI         A+WD+        F GHT     + +S D     +G  
Sbjct: 146 -LSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGAC 204

Query: 627 DNTVRSWDLREGRQLQQH-DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLH 685
           D + + WD+REG   Q      S I ++ + P GE +  G + ++  +       +    
Sbjct: 205 DASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICF 264

Query: 686 LHESC---VLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSC-DISADD 741
            HES    + S+ F+  G+   +   D   N W +     +       + +SC  ++AD 
Sbjct: 265 SHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADG 324

Query: 742 KYIVTGSGD 750
             + TGS D
Sbjct: 325 MAVATGSWD 333



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 50/198 (25%), Positives = 82/198 (41%), Gaps = 7/198 (3%)

Query: 522 YIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFS 581
           Y+  C+ L D   +   G+ +T  +WD+   T + K         C +LA+SPD  +  S
Sbjct: 145 YLSCCRFLDDNNIVTSSGD-TTCALWDIE--TGQQKTVFVGHTGDCMSLAVSPDFNLFIS 201

Query: 582 CCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQL 641
              D +  +WD+   T  + F GH    + I    +G  + TG  D + R +DLR  ++L
Sbjct: 202 GACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQEL 261

Query: 642 ---QQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQ-LHLHESCVLSLKFA 697
                      I S+ +  +G  L  G +  N  V    K ++   L  H++ V  L   
Sbjct: 262 ICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVT 321

Query: 698 YCGKWFVSTGKDNLLNAW 715
             G    +   D+ L  W
Sbjct: 322 ADGMAVATGSWDSFLKIW 339



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 33/159 (20%), Positives = 67/159 (42%), Gaps = 7/159 (4%)

Query: 478 CAVTISNPTRHVYTGGK--GCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTL 535
           C     +P  +++  G      K+WD+ +   +   +       ++ I +    P+G  +
Sbjct: 187 CMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFT-----GHESDINAICFFPNGEAI 241

Query: 536 IVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHN 595
             G + ++  ++DL +    I     S      ++A S   ++ F+   D N  VWD   
Sbjct: 242 CTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMK 301

Query: 596 QTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWD 634
              V    GH +  SC+ ++ DG  + TG  D+ ++ W+
Sbjct: 302 SERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340



 Score = 37.7 bits (86), Expect = 0.040
 Identities = 53/220 (24%), Positives = 81/220 (36%), Gaps = 33/220 (15%)

Query: 555 RIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDI 614
           R +  L       YA+  + D+K+  S   DG + VWD +    V      +        
Sbjct: 46  RTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY 105

Query: 615 SHDGTKLWTGGLDNTVRSWDL--REG-----RQLQQH----------DFTSQIFSLGYCP 657
           +  G  +  GGLDN    ++L  REG     R+L  H          D  + + S G   
Sbjct: 106 APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTT 165

Query: 658 TGEWLAVGMESSNVEVLH-------HTKPDKYQLHLHESCVLSLKF-----AYCGKWFVS 705
              W     +   V V H          PD + L +  +C  S K        C + F  
Sbjct: 166 CALWDIETGQQKTVFVGHTGDCMSLAVSPD-FNLFISGACDASAKLWDVREGTCRQTF-- 222

Query: 706 TGKDNLLNA-WRTPYGASIFQSKESSSVLSCDISADDKYI 744
           TG ++ +NA    P G +I    + +S    D+ AD + I
Sbjct: 223 TGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELI 262



 Score = 33.5 bits (75), Expect = 0.75
 Identities = 30/129 (23%), Positives = 59/129 (45%), Gaps = 7/129 (5%)

Query: 635 LREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDK-YQLHLHESCVLS 693
           +R  R L+ H   ++I+++ +    + L    +   + V      +K + + L  S V++
Sbjct: 45  MRTRRTLRGH--LAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMT 102

Query: 694 LKFAYCGKWFVSTGKDNLLNAWRTPYG-ASIFQSKESSS---VLSCDISADDKYIVTGSG 749
             +A  G +    G DN+ + +       ++  S+E S+    LSC    DD  IVT SG
Sbjct: 103 CAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSG 162

Query: 750 DKKATVYEV 758
           D    ++++
Sbjct: 163 DTTCALWDI 171


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 43/154 (27%), Positives = 75/154 (48%), Gaps = 8/154 (5%)

Query: 530 PDGRTLIVGGEASTLTIWDLASPT-PRIKAELTSSAPACYALAISPDAKVCFSCCSDGNI 588
           P+   +  G    T+ +WD+ +    RI    T      ++L  SP+ +   +  +DG +
Sbjct: 637 PNSNYVATGSADRTVRLWDVLNGNCVRI---FTGHKGPIHSLTFSPNGRFLATGATDGRV 693

Query: 589 AVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWD-LREGRQLQQHDFT 647
            +WD+ +  +V + +GHTD    +  S DG  L +G +DNTVR WD ++    L+  DFT
Sbjct: 694 LLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFT 753

Query: 648 SQIFSLGYCPTGEWLAVG---MESSNVEVLHHTK 678
           +    +      + L +G    +S+ V  LH T+
Sbjct: 754 TATGHINLPENSQELLLGTYMTKSTPVVHLHFTR 787



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 51/233 (21%), Positives = 92/233 (39%), Gaps = 13/233 (5%)

Query: 540 EASTLTIWDLASPT--PRIKAELTSS--------APACYALAISPDAKVCFSCCSDGNIA 589
           +AS L++ D  S     RI  E T+S        +   Y  + SPD     S   DG + 
Sbjct: 509 QASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVR 568

Query: 590 VWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQH-DFTS 648
           +W L   T +  ++GH         S  G    +GG D   R W     + L+      +
Sbjct: 569 LWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLA 628

Query: 649 QIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHL-HESCVLSLKFAYCGKWFVSTG 707
            +    + P   ++A G     V +      +  ++   H+  + SL F+  G++  +  
Sbjct: 629 DVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGA 688

Query: 708 KDNLLNAWRTPYGASIFQSK-ESSSVLSCDISADDKYIVTGSGDKKATVYEVI 759
            D  +  W   +G  + + K  + +V S   S D + + +GS D    +++ I
Sbjct: 689 TDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 27/115 (23%), Positives = 42/115 (36%), Gaps = 22/115 (19%)

Query: 486 TRHVYTGGKG-CVKIWDISQ-------PGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIV 537
           + +V TG     V++WD+          G K PI  L               P+GR L  
Sbjct: 639 SNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLT------------FSPNGRFLAT 686

Query: 538 GGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWD 592
           G     + +WD+      +  EL        +L  S D ++  S   D  + +WD
Sbjct: 687 GATDGRVLLWDIGHGL--MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 29/100 (29%), Positives = 45/100 (45%), Gaps = 14/100 (14%)

Query: 87  TILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGQ----------QQLQAQHLSHA 136
           T+LA ++ FL Q   ++  +A+ R  +  + E  A+ G            ++ +  LS  
Sbjct: 96  TLLA-VLQFLRQSKLREAEEALRR--EAGLLE-EAVAGSGAPGEVDSAGAEVTSALLSRV 151

Query: 137 THGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQA 176
           T   P    P P G    G   V+GS+SG  A G +GS A
Sbjct: 152 TASAPGPAAPDPPGTGASGATVVSGSASGPAAPGKVGSVA 191


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,085,661
Number of Sequences: 37866
Number of extensions: 1810413
Number of successful extensions: 12582
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 231
Number of HSP's successfully gapped in prelim test: 762
Number of HSP's that attempted gapping in prelim test: 8849
Number of HSP's gapped (non-prelim): 3517
length of query: 760
length of database: 18,247,518
effective HSP length: 110
effective length of query: 650
effective length of database: 14,082,258
effective search space: 9153467700
effective search space used: 9153467700
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.