Search of human proteins with 157276597

Search of human proteins with 157276597

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
         (408 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa...   845   0.0  
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa...   845   0.0  
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa...   845   0.0  
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi...   484   e-137
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]      189   4e-48
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi...   185   7e-47
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap...   177   1e-44
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa...   174   1e-43
gi|145611428 bone morphogenetic protein 8A [Homo sapiens]             174   1e-43
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap...   153   3e-37
gi|4503969 growth differentiation factor 5 preproprotein [Homo s...   152   7e-37
gi|10190670 growth differentiation factor 3 precursor [Homo sapi...   150   2e-36
gi|61835232 growth differentiation factor 7 preproprotein [Homo ...   150   2e-36
gi|7705308 growth differentiation factor 2 [Homo sapiens]             145   6e-35
gi|48475062 growth differentiation factor 6 precursor [Homo sapi...   143   3e-34
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa...   119   4e-27
gi|4826740 growth differentiation factor 10 precursor [Homo sapi...   112   5e-25
gi|222352098 nodal precursor [Homo sapiens]                           104   1e-22
gi|4504699 inhibin beta A precursor [Homo sapiens]                    102   8e-22
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]     102   8e-22
gi|110349792 growth differentiation factor 1 [Homo sapiens]           100   3e-21
gi|4507465 transforming growth factor, beta 3 [Homo sapiens]           97   2e-20
gi|13899338 activin beta E [Homo sapiens]                              96   4e-20
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]       95   1e-19
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ...    87   3e-17
gi|5031613 growth differentiation factor 11 precursor [Homo sapi...    85   1e-16
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]    85   1e-16
gi|4885259 myostatin [Homo sapiens]                                    85   1e-16
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa...    85   1e-16
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]           83   5e-16

>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  845 bits (2182), Expect = 0.0
 Identities = 408/408 (100%), Positives = 408/408 (100%)

Query: 1   MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEAT 60
           MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEAT
Sbjct: 1   MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEAT 60

Query: 61  LLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSF 120
           LLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSF
Sbjct: 61  LLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSF 120

Query: 121 HHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINI 180
           HHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINI
Sbjct: 121 HHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINI 180

Query: 181 YEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTH 240
           YEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTH
Sbjct: 181 YEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTH 240

Query: 241 LHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQR 300
           LHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQR
Sbjct: 241 LHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQR 300

Query: 301 ARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTL 360
           ARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTL
Sbjct: 301 ARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTL 360

Query: 361 VNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
           VNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
Sbjct: 361 VNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  845 bits (2182), Expect = 0.0
 Identities = 408/408 (100%), Positives = 408/408 (100%)

Query: 1   MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEAT 60
           MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEAT
Sbjct: 1   MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEAT 60

Query: 61  LLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSF 120
           LLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSF
Sbjct: 61  LLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSF 120

Query: 121 HHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINI 180
           HHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINI
Sbjct: 121 HHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINI 180

Query: 181 YEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTH 240
           YEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTH
Sbjct: 181 YEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTH 240

Query: 241 LHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQR 300
           LHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQR
Sbjct: 241 LHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQR 300

Query: 301 ARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTL 360
           ARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTL
Sbjct: 301 ARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTL 360

Query: 361 VNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
           VNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
Sbjct: 361 VNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  845 bits (2182), Expect = 0.0
 Identities = 408/408 (100%), Positives = 408/408 (100%)

Query: 1   MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEAT 60
           MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEAT
Sbjct: 1   MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEAT 60

Query: 61  LLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSF 120
           LLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSF
Sbjct: 61  LLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSF 120

Query: 121 HHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINI 180
           HHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINI
Sbjct: 121 HHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINI 180

Query: 181 YEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTH 240
           YEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTH
Sbjct: 181 YEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTH 240

Query: 241 LHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQR 300
           LHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQR
Sbjct: 241 LHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQR 300

Query: 301 ARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTL 360
           ARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTL
Sbjct: 301 ARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTL 360

Query: 361 VNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
           VNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
Sbjct: 361 VNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
           sapiens]
          Length = 396

 Score =  484 bits (1247), Expect = e-137
 Identities = 258/414 (62%), Positives = 303/414 (73%), Gaps = 24/414 (5%)

Query: 1   MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQ-SHELLRDFEA 59
           M+ G R L+ +LL QVLLGGA  A L+PE G++K A     + GR S Q S E+L +FE 
Sbjct: 1   MVAGTRCLLALLLPQVLLGGA--AGLVPELGRRKFAAA---SSGRPSSQPSDEVLSEFEL 55

Query: 60  TLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYP----ERPASRAN 115
            LL MFGL++RP PS+ AV+P YM DLYR  SG+         G   P    ER ASRAN
Sbjct: 56  RLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQP--------GSPAPDHRLERAASRAN 107

Query: 116 TVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGF 175
           TVRSFHHEE LE +P TS  +  RF FNLSSIP  E I+SAEL++FREQ+         F
Sbjct: 108 TVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSF 167

Query: 176 H-RINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGL 234
           H RINIYE++KP A       +TRLLDTRLV+ N +RWE+FDV+PAV+RWT +   N+G 
Sbjct: 168 HHRINIYEIIKP-ATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGF 226

Query: 235 AIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSP 294
            +EV HL + +    +HVRISRSL Q   +W+Q+RPLLVTFGHDG+GH L   +R KR  
Sbjct: 227 VVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPL--HKREKRQA 284

Query: 295 KHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNH 354
           KH  QR R K+ +C+RH LYVDFSDVGWNDWIVAPPGY AFYCHG+CPFPLADHLNSTNH
Sbjct: 285 KH-KQRKRLKS-SCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNH 342

Query: 355 AIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
           AIVQTLVNSVNS IPKACCVPTELSAISMLYLDE +KVVLKNYQ+MVVEGCGCR
Sbjct: 343 AIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396


>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
          Length = 431

 Score =  189 bits (480), Expect = 4e-48
 Identities = 128/393 (32%), Positives = 192/393 (48%), Gaps = 54/393 (13%)

Query: 55  RDFEATLLQMFGLRRRPQP---SKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPA 111
           R+ +  +L + GL  RP+P    K    P +M DLY   + EE        G  YP +  
Sbjct: 52  REMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGP-GGQGFSYPYKAV 110

Query: 112 -----------------SRANTVRSFHH--EEHLENIPGTSENSAFRFLFNLSSIPENEV 152
                            + A+ V SF +  E   E       +  FRF  +LS IPE E 
Sbjct: 111 FSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRF--DLSKIPEGEA 168

Query: 153 ISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRW 212
           +++AE R++++ + +  D E    RI++Y+V++   E +       LLD+R +  +   W
Sbjct: 169 VTAAEFRIYKDYIRERFDNET--FRISVYQVLQ---EHLGRESDLFLLDSRTLWASEEGW 223

Query: 213 ETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLL 272
             FD++     W    + N GL + V  L     +      I R  PQ        +P +
Sbjct: 224 LVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNK------QPFM 277

Query: 273 VTFGHDGRGHALT------RRRRAKRSPKHHSQRARK-----------KNKNCRRHSLYV 315
           V F      H  +      ++R   RS    +Q A +           + + C++H LYV
Sbjct: 278 VAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYV 337

Query: 316 DFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCV 374
            F D+GW DWI+AP GY A+YC G+C FPL  ++N+TNHAIVQTLV+ +N  ++PK CC 
Sbjct: 338 SFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCA 397

Query: 375 PTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407
           PT+L+AIS+LY D+   V+LK Y+ MVV  CGC
Sbjct: 398 PTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430


>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
           sapiens]
          Length = 513

 Score =  185 bits (469), Expect = 7e-47
 Identities = 113/286 (39%), Positives = 152/286 (53%), Gaps = 29/286 (10%)

Query: 140 FLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEVVPGHLITRL 199
           F FNLS IPE EV+++AE R++++ V  G    + F  I+IY+V++   E         L
Sbjct: 238 FKFNLSQIPEGEVVTAAEFRIYKDCV-MGSFKNQTF-LISIYQVLQ---EHQHRDSDLFL 292

Query: 200 LDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLP 259
           LDTR+V  +   W  FD++     W    Q N GL + V       T  G HV    +  
Sbjct: 293 LDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVV------TRDGVHVHPRAAGL 346

Query: 260 QGSGNWAQLRPLLVTFGHDGRGHALT------RRRRAKRSPKHHSQRARKKNKN------ 307
            G       +P +V F      H  T      RRR+  R+    SQ   + +        
Sbjct: 347 VGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSS 406

Query: 308 -----CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVN 362
                CR+H LYV F D+GW DWI+AP GY A YC G+C FPL  H+N+TNHAIVQTLV+
Sbjct: 407 ELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVH 466

Query: 363 SVNSS-IPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407
            +N   +PK CC PT+L+AIS+LY D+   V+LK Y+ MVV  CGC
Sbjct: 467 LMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512


>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
           sapiens]
          Length = 454

 Score =  177 bits (450), Expect = 1e-44
 Identities = 123/422 (29%), Positives = 197/422 (46%), Gaps = 75/422 (17%)

Query: 49  QSHELLRDFEATLLQMFGLRRRPQP----SKSAVIPDYMRDLYRLQSGEEEEEQ----IH 100
           ++HE  R+ +  +L + GL  RP+P     +++  P +M DLY   + EE  E+    + 
Sbjct: 44  RNHER-REIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVR 102

Query: 101 STGLE--------YPERP---------------ASRANTVRSFHHEEHLE---------N 128
           ++  E        YP  P                +++  + S H    L          N
Sbjct: 103 ASLAEETRGARKGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVN 162

Query: 129 IPGTSENSAFR------FLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINIYE 182
           +    ++ + +      F F+L+ IP  E +++AE R+++++ +    +E    +I+IY+
Sbjct: 163 LVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNR--FENETIKISIYQ 220

Query: 183 VMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLH 242
           ++K   E         LLDTR        W  FD++     W    Q N GL +      
Sbjct: 221 IIK---EYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQL------ 271

Query: 243 QTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGR------GHALTRRRRAKRSPKH 296
              T  G+ + +  +   G       +P +V F             A  R+ + +     
Sbjct: 272 CAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSS 331

Query: 297 HSQRAR----------KKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLA 346
           H   +R          ++ + C++H LYV F D+GW DWI+AP GY AFYC G+C FPL 
Sbjct: 332 HQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLN 391

Query: 347 DHLNSTNHAIVQTLVNSV-NSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGC 405
            H+N+TNHAIVQTLV+ +    +PK CC PT+L+AIS+LY D+   V+LK Y+ MVV  C
Sbjct: 392 AHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSC 451

Query: 406 GC 407
           GC
Sbjct: 452 GC 453


>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
           sapiens]
          Length = 402

 Score =  174 bits (442), Expect = 1e-43
 Identities = 133/434 (30%), Positives = 203/434 (46%), Gaps = 64/434 (14%)

Query: 2   IPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATL 61
           +PG   L+ + LC +  GG     L P  G  +          RR G      RD +  +
Sbjct: 4   LPGPLWLLGLALCALGGGGPG---LRPPPGCPQ----------RRLGARER--RDVQREI 48

Query: 62  LQMFGLRRRPQPSKS-------AVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRA 114
           L + GL  RP+P          A  P +M DLY   +G+++E+   +      ER   RA
Sbjct: 49  LAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPA------ERRLGRA 102

Query: 115 NTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERG 174
           + V SF +    +   G  E     F F+L+ IP  E +++AE R+++  V       R 
Sbjct: 103 DLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYK--VPSIHLLNRT 160

Query: 175 FHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGL 234
            H +++++V++  +           LD + +      W   DV+ A   W  ++  + GL
Sbjct: 161 LH-VSMFQVVQEQSNRESDLFF---LDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGL 216

Query: 235 AIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALT-------RR 287
            + V       T  G  V    +   G       +P +VTF         T       RR
Sbjct: 217 RLYV------ETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRR 270

Query: 288 RRAKRSPKH-------------HSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQA 334
           R+ K+S +              H    R+    CRRH LYV F D+GW DW++AP GY A
Sbjct: 271 RQPKKSNELPQANRLPGIFDDVHGSHGRQV---CRRHELYVSFQDLGWLDWVIAPQGYSA 327

Query: 335 FYCHGDCPFPLADHLNSTNHAIVQTLVN-SVNSSIPKACCVPTELSAISMLYLDEYDKVV 393
           +YC G+C FPL   +N+TNHAI+Q+LV+  +  ++PKACC PT+LSA S+LY D  + V+
Sbjct: 328 YYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVI 387

Query: 394 LKNYQEMVVEGCGC 407
           L+ ++ MVV+ CGC
Sbjct: 388 LRKHRNMVVKACGC 401


>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
          Length = 402

 Score =  174 bits (441), Expect = 1e-43
 Identities = 118/378 (31%), Positives = 185/378 (48%), Gaps = 43/378 (11%)

Query: 55  RDFEATLLQMFGLRRRPQPSKS-------AVIPDYMRDLYRLQSGEEEEEQIHSTGLEYP 107
           RD +  +L + GL  RP+P          A  P +M DLY   +G+++E+   +      
Sbjct: 42  RDVQREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPA------ 95

Query: 108 ERPASRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQ 167
           E+   RA+ V SF +    +   G  E     F F+L+ IP  E +++AE R+++  V  
Sbjct: 96  EQRLGRADLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYK--VPS 153

Query: 168 GPDWERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTRE 227
                R  H +++++V++  +           LD + +      W   DV+ A   W  +
Sbjct: 154 IHLLNRTLH-VSMFQVVQEQSNRESDLFF---LDLQTLRAGDEGWLVLDVTAASDCWLLK 209

Query: 228 KQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALT-- 285
           +  + GL + V       T  G  V    +   G       +P +VTF         T  
Sbjct: 210 RHKDLGLRLYV------ETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPR 263

Query: 286 -----RRRRAKRSPK----------HHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPP 330
                RRR+ K+S +              R     + CRRH LYV F D+GW DW++AP 
Sbjct: 264 AVRPLRRRQPKKSNELPQANRLPGIFDDVRGSHGRQVCRRHELYVSFQDLGWLDWVIAPQ 323

Query: 331 GYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISMLYLDEY 389
           GY A+YC G+C FPL   +N+TNHAI+Q+LV+ +  +++PKACC PT+LSA S+LY D  
Sbjct: 324 GYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSS 383

Query: 390 DKVVLKNYQEMVVEGCGC 407
           + V+L+ ++ MVV+ CGC
Sbjct: 384 NNVILRKHRNMVVKACGC 401


>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
           sapiens]
          Length = 424

 Score =  153 bits (386), Expect = 3e-37
 Identities = 116/395 (29%), Positives = 171/395 (43%), Gaps = 63/395 (15%)

Query: 53  LLRDFEATLLQMFGLRRRP-QPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPA 111
           LL+  +   L+   L   P Q S     P+YM +LY            +    +    P+
Sbjct: 54  LLQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELY------------NKFATDRTSMPS 101

Query: 112 SRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDW 171
             AN +RSF +E+        +    +  LFN+S IP +E +  AELRL+         +
Sbjct: 102 --ANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVS-IPHHEEVIMAELRLYTLVQRDRMIY 158

Query: 172 ERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPN 231
           +    +I I+EV++   +   G     +L +  ++   + WETFDV+ A+ RW +     
Sbjct: 159 DGVDRKITIFEVLESKGDN-EGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSST 217

Query: 232 YGLAIEVTHLH-QTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRA 290
           + L + +   H +        + I  S  Q   N     PLL+ F  D        R+  
Sbjct: 218 HQLEVHIESKHDEAEDASSGRLEIDTSA-QNKHN-----PLLIVFSDDQSSDK--ERKEE 269

Query: 291 KRSPKHHSQ------------------------------------RARKKNKNCRRHSLY 314
                 H Q                                    R   K   C+R  LY
Sbjct: 270 LNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLY 329

Query: 315 VDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNS-SIPKACC 373
           +DF ++GW+ WI+APPGY+A+ C G C +PLA+HL  T HAI+Q LV+  NS    KACC
Sbjct: 330 IDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACC 389

Query: 374 VPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
           VPT+L  IS+LYLD+        Y+ M V  CGCR
Sbjct: 390 VPTKLEPISILYLDKGVVTYKFKYEGMAVSECGCR 424


>gi|4503969 growth differentiation factor 5 preproprotein [Homo
           sapiens]
          Length = 501

 Score =  152 bits (383), Expect = 7e-37
 Identities = 112/345 (32%), Positives = 171/345 (49%), Gaps = 31/345 (8%)

Query: 81  DYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRF 140
           +YM  LYR  S  + +    S  LE     A  ANT+ SF  +   +  P   +    R+
Sbjct: 171 EYMLSLYRTLSDADRKGGNSSVKLE-----AGLANTITSFIDKGQDDRGPVVRKQ---RY 222

Query: 141 LFNLSSIPENEVISSAELRLFREQV-DQGPDWERGFHRINIYEVMKPPAEVVPGHLITRL 199
           +F++S++ E + +  AELR+ R++  D       G  R    ++   P+    G     L
Sbjct: 223 VFDISAL-EKDGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPS----GRQPASL 277

Query: 200 LDTRLVHH-NVTRWETFDVSPAVLRWTREKQP-------NYGLAIEVTHLHQTRTHQGQH 251
           LD R V   + + WE FD+      +    Q          G A+++  L   R  +  H
Sbjct: 278 LDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVH 337

Query: 252 VRISRSLPQGSGNWAQL--RPLLVTFGHDGRG-----HALTRRRRAKRSPKHHSQRARKK 304
            + +  L  G      L    +    G D +       +  R+RRA  + +   + ++  
Sbjct: 338 EK-ALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNL 396

Query: 305 NKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSV 364
              C R +L+V+F D+GW+DWI+AP  Y+AF+C G C FPL  HL  TNHA++QTL+NS+
Sbjct: 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSM 456

Query: 365 N-SSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
           +  S P  CCVPT LS IS+L++D  + VV K Y++MVVE CGCR
Sbjct: 457 DPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501


>gi|10190670 growth differentiation factor 3 precursor [Homo
           sapiens]
          Length = 364

 Score =  150 bits (380), Expect = 2e-36
 Identities = 111/369 (30%), Positives = 175/369 (47%), Gaps = 50/369 (13%)

Query: 58  EATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLE----YPERPASR 113
           E   LQ  GL + P P K   +P  ++ ++      ++ E   +TG+     Y +    R
Sbjct: 26  EYVFLQFLGLDKAPSPQKFQPVPYILKKIF------QDREAAATTGVSRDLCYVKELGVR 79

Query: 114 ANTVRSFHHEEHL---ENIPGTSENSAFRFLFNLSSIPENEVISSAELRLF---REQVDQ 167
            N +R    +      + I   S        FNLS+I E E ++ A+L L        + 
Sbjct: 80  GNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNLSAIKEREQLTLAQLGLDLGPNSYYNL 139

Query: 168 GPDWERGFHRINIYEVMKP----PAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLR 223
           GP+ E     + ++ V +P         PG +   +L +         +   DV+     
Sbjct: 140 GPELE-----LALFLVQEPHVWGQTTPKPGKMF--VLRSVPWPQGAVHFNLLDVAKD--- 189

Query: 224 WTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLR-----PLLVTFGHD 278
           W    + N+GL +E+      +  +   V       Q     A+LR      LLV   + 
Sbjct: 190 WNDNPRKNFGLFLEIL----VKEDRDSGVNF-----QPEDTCARLRCSLHASLLVVTLNP 240

Query: 279 GRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCH 338
            + H   +RR A   PK   +        C RH L+++F D+GW+ WI+AP G+ A YCH
Sbjct: 241 DQCHPSRKRRAAIPVPKLSCKNL------CHRHQLFINFRDLGWHKWIIAPKGFMANYCH 294

Query: 339 GDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQ 398
           G+CPF L   LNS+N+A +Q L+++V+  IP+A C+PT+LS ISMLY D  D V+L++Y+
Sbjct: 295 GECPFSLTISLNSSNYAFMQALMHAVDPEIPQAVCIPTKLSPISMLYQDNNDNVILRHYE 354

Query: 399 EMVVEGCGC 407
           +MVV+ CGC
Sbjct: 355 DMVVDECGC 363


>gi|61835232 growth differentiation factor 7 preproprotein [Homo
           sapiens]
          Length = 450

 Score =  150 bits (380), Expect = 2e-36
 Identities = 113/352 (32%), Positives = 162/352 (46%), Gaps = 74/352 (21%)

Query: 113 RANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFRE-QVDQGP-D 170
           RA+T+  F  +   +     +  S   FLF++SS+ + + +  AELR+ R    + GP  
Sbjct: 117 RADTITGFTDQATQDESAAETGQS---FLFDVSSLNDADEVVGAELRVLRRGSPESGPGS 173

Query: 171 WERGFHRINIYEVMKPPAEVV---PGHL-ITRLLDTRLVHHNV-TRWETFDVSPAVLRWT 225
           W              PP  ++   PG     RLL +R     V  RWE FDV+ A+ R  
Sbjct: 174 WT------------SPPLLLLSTCPGAARAPRLLYSRAAEPLVGQRWEAFDVADAMRRHR 221

Query: 226 REKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALT 285
           RE +P     + +  +           R+    P G G+ A+ R +LV      R  +L 
Sbjct: 222 REPRPPRAFCLLLRAVAGPVPSPLALRRLGFGWPGGGGSAAEERAVLVVSSRTQRKESLF 281

Query: 286 RRRRAKR--------------------SPKH----------------------------H 297
           R  RA+                     SP+                             H
Sbjct: 282 REIRAQARALGAALASEPLPDPGTGTASPRAVIGGRRRRRTALAGTRTAQGSGGGAGRGH 341

Query: 298 SQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIV 357
            +R R +   C R  L+VDF ++GW+DWI+AP  Y+A++C G C FPL  HL  TNHAI+
Sbjct: 342 GRRGRSR---CSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAII 398

Query: 358 QTLVNSV-NSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
           QTL+NS+   + P +CCVP  LS IS+LY+D  + VV K Y++MVVE CGCR
Sbjct: 399 QTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR 450


>gi|7705308 growth differentiation factor 2 [Homo sapiens]
          Length = 429

 Score =  145 bits (366), Expect = 6e-35
 Identities = 129/403 (32%), Positives = 181/403 (44%), Gaps = 80/403 (19%)

Query: 54  LRDFEATLLQMFGLRRRPQPSKSAVIP-DYMRDLYRLQSGEEEEEQIHSTGLEYPERPAS 112
           L + +   L+   L   P   K+ V P  YM DLY   + ++               PAS
Sbjct: 59  LENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTT------------PAS 106

Query: 113 RANTVRSFHHEEHLENIPGTSENSAFR---FLFNLSSIPENEVISSAELRLF---REQVD 166
             N VRSF  E+ + +I  T E+  F+    LFN+S IP +E I+ AELRL+   +  VD
Sbjct: 107 --NIVRSFSMEDAI-SITAT-EDFPFQKHILLFNIS-IPRHEQITRAELRLYVSCQNHVD 161

Query: 167 QGPDWERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTR--WETFDVSPAVLRW 224
              D +     + IY+V+    +       T+   T LV  ++    WET +VS AV RW
Sbjct: 162 PSHDLKGS---VVIYDVLDG-TDAWDSATETK---TFLVSQDIQDEGWETLEVSSAVKRW 214

Query: 225 TREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHAL 284
            R         +EVT      +H+     +  S+P GS N     P  V F +D      
Sbjct: 215 VRSDSTKSKNKLEVT----VESHRKGCDTLDISVPPGSRNL----PFFVVFSNDHSSGTK 266

Query: 285 TRRRRAKRSPKHHSQRARKK-------------------------------------NKN 307
             R   +    H  +   KK                                       +
Sbjct: 267 ETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSH 326

Query: 308 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVN-SVNS 366
           C++ SL V+F D+GW+ WI+AP  Y+A+ C G C FPLAD +  T HAIVQTLV+    +
Sbjct: 327 CQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPT 386

Query: 367 SIPKACCVPTELSAISMLYLDEYDKVVLK-NYQEMVVEGCGCR 408
            + KACCVPT+LS IS+LY D+     LK +Y+ M V  CGCR
Sbjct: 387 KVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR 429


>gi|48475062 growth differentiation factor 6 precursor [Homo
           sapiens]
          Length = 455

 Score =  143 bits (360), Expect = 3e-34
 Identities = 62/124 (50%), Positives = 88/124 (70%), Gaps = 1/124 (0%)

Query: 286 RRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPL 345
           RRRR   + +H  +  +K    C +  L+V+F ++GW+DWI+AP  Y+A++C G C FPL
Sbjct: 332 RRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPL 391

Query: 346 ADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEG 404
             HL  TNHAI+QTL+NS++  S P +CCVPT+L+ IS+LY+D  + VV K Y++MVVE 
Sbjct: 392 RSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVES 451

Query: 405 CGCR 408
           CGCR
Sbjct: 452 CGCR 455


>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
           sapiens]
          Length = 472

 Score =  119 bits (299), Expect = 4e-27
 Identities = 55/138 (39%), Positives = 84/138 (60%), Gaps = 16/138 (11%)

Query: 287 RRRAKRSPKHHSQ----------RARKKN----KNCRRHSLYVDFSDVGWNDWIVAPPGY 332
           +++ ++ P   SQ          +AR+K     +NC R  L VDF+D+GW++WI++P  +
Sbjct: 335 KKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSF 394

Query: 333 QAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN--SSIPKACCVPTELSAISMLYLDEYD 390
            A+YC G C FP+   L  +NHA +Q++V +V     IP+ CCVP ++S++S+L+ DE  
Sbjct: 395 DAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENK 454

Query: 391 KVVLKNYQEMVVEGCGCR 408
            VVLK Y  M VE C CR
Sbjct: 455 NVVLKVYPNMTVESCACR 472


>gi|4826740 growth differentiation factor 10 precursor [Homo
           sapiens]
          Length = 478

 Score =  112 bits (281), Expect = 5e-25
 Identities = 50/116 (43%), Positives = 76/116 (65%), Gaps = 6/116 (5%)

Query: 299 QRARKKN----KNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNH 354
           Q+AR+K     + C R  L VDF+D+GWN+WI++P  + A+YC G C FP+   +  +NH
Sbjct: 363 QKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNH 422

Query: 355 AIVQTLVNSVN--SSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
           A +Q++V +V     IP+ CCVP +++++ +L+LDE   VVLK Y  M V+ C CR
Sbjct: 423 ATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478


>gi|222352098 nodal precursor [Homo sapiens]
          Length = 347

 Score =  104 bits (260), Expect = 1e-22
 Identities = 98/368 (26%), Positives = 152/368 (41%), Gaps = 77/368 (20%)

Query: 67  LRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHL 126
           LR R QPS  + +  YM  LYR                     P  RA+ +RS   E+  
Sbjct: 29  LRTRGQPSSPSPLA-YMLSLYR--------------------DPLPRADIIRSLQAEDV- 66

Query: 127 ENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINIYEVMKP 186
                  +   + F F+ S + + E ++ AELRL        P    G   I I+   KP
Sbjct: 67  -----AVDGQNWTFAFDFSFLSQQEDLAWAELRLQLSSPVDLPT--EGSLAIEIFHQPKP 119

Query: 187 PAEVVPGHLITRLLDTRLVHHNVTRWE-TFDVSPAVLRWTR------------EKQ---- 229
             E      + R    ++    VT  + TF +   VL  TR            EKQ    
Sbjct: 120 DTEQASDSCLERF---QMDLFTVTLSQVTFSLGSMVLEVTRPLSKWLKHPGALEKQMSRV 176

Query: 230 --------PNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNW-AQLRPLLVTFGHDGR 280
                   P       +  L+   + + + +  S  L +   +W AQ   L   +G    
Sbjct: 177 AGECWPRPPTPPATNVLLMLYSNLSQEQRQLGGSTLLWEAESSWRAQEGQLSWEWG---- 232

Query: 281 GHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGD 340
                     KR  +HH      +++ CR+    VDF+ +GW  WI+ P  Y A+ C G+
Sbjct: 233 ----------KRHRRHHLP---DRSQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGE 279

Query: 341 CPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISMLYLDEYDKVVLKNYQE 399
           CP P+ +  + TNHA +Q+L+       +P  CC P +   +SMLY+D   +V+L ++++
Sbjct: 280 CPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVDN-GRVLLDHHKD 338

Query: 400 MVVEGCGC 407
           M+VE CGC
Sbjct: 339 MIVEECGC 346


>gi|4504699 inhibin beta A precursor [Homo sapiens]
          Length = 426

 Score =  102 bits (253), Expect = 8e-22
 Identities = 99/396 (25%), Positives = 165/396 (41%), Gaps = 63/396 (15%)

Query: 52  ELLRDFEATLLQMFGLRRRP---QPSKSAVIPDYMRDLYRLQSGE--------------E 94
           E++   +  +L M  L++RP   QP   A + + +R L+  + GE              E
Sbjct: 53  EMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAE 112

Query: 95  EEEQIHSTG--LEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEV 152
             E +  T   + + E   +R    ++ H E   E    +    A  +LF L     N  
Sbjct: 113 MNELMEQTSEIITFAESGTAR----KTLHFEISKEGSDLSVVERAEVWLF-LKVPKANRT 167

Query: 153 ISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEV-VPGHLITRLLDTRLVHHNVTR 211
            +   +RLF++Q       + G          +   EV + G     LL  ++V    + 
Sbjct: 168 RTKVTIRLFQQQKHPQGSLDTG----------EEAEEVGLKGERSELLLSEKVVDARKST 217

Query: 212 WETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPL 271
           W  F VS ++ R   + + +  + I      ++        +  +   +G G        
Sbjct: 218 WHVFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKG---- 273

Query: 272 LVTFGHDGRG--------HALTRRRRAKRSPKHHSQRARK------KNKNCRRHSLYVDF 317
               G  G G        H      +A++S  H  +R R+      K   C +   +V F
Sbjct: 274 ---GGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSF 330

Query: 318 SDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVN--SVNSSIP----KA 371
            D+GWNDWI+AP GY A YC G+CP  +A   + ++ +   T++N   +    P    K+
Sbjct: 331 KDIGWNDWIIAPSGYHANYCEGECPSHIAG-TSGSSLSFHSTVINHYRMRGHSPFANLKS 389

Query: 372 CCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407
           CCVPT+L  +SMLY D+   ++ K+ Q M+VE CGC
Sbjct: 390 CCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425


>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
          Length = 392

 Score =  102 bits (253), Expect = 8e-22
 Identities = 60/170 (35%), Positives = 87/170 (51%), Gaps = 13/170 (7%)

Query: 241 LHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLV-TFGHDGRGHALTRRRRAKRSPKHHSQ 299
           L+   TH+   +R ++ LP+G   + +   LL  T   DG    +T       S KH   
Sbjct: 234 LYFNDTHKS--IRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTAS-----SSKHSGP 286

Query: 300 RARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQT 359
               +N  C  H   + F  +GW+ WI+APP Y   YC G C   L D LNS NHAI+Q 
Sbjct: 287 ----ENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQN 342

Query: 360 LVNS-VNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
           L+N  V+ S+P+  CVP +   IS+L ++    ++ K Y+ M+ E C CR
Sbjct: 343 LINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR 392


>gi|110349792 growth differentiation factor 1 [Homo sapiens]
          Length = 372

 Score =  100 bits (248), Expect = 3e-21
 Identities = 46/106 (43%), Positives = 66/106 (62%), Gaps = 5/106 (4%)

Query: 308 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLA----DHLNSTNHAIVQTLVN- 362
           CR   LYV F +VGW+ W++AP G+ A YC G C  P+A        + NHA+++ L++ 
Sbjct: 267 CRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHA 326

Query: 363 SVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
           +   +    CCVP  LS IS+L+ D  D VVL+ Y++MVV+ CGCR
Sbjct: 327 AAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR 372


>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
          Length = 412

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 98/384 (25%), Positives = 161/384 (41%), Gaps = 56/384 (14%)

Query: 61  LLQMFGLRRRPQPSKSAVIP-------DYMRDLYRLQSGEEEEEQIH-STGLEYPERPAS 112
           +L    L   P+P+    +P       +  R+L     GE EE     +T  EY  +   
Sbjct: 47  ILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIH 106

Query: 113 RANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEV-ISSAELRLFREQVDQGPDW 171
           + + ++       L   P    +  FRF  N+SS+ +N   +  AE R+ R      P  
Sbjct: 107 KFDMIQGLAEHNELAVCPKGITSKVFRF--NVSSVEKNRTNLFRAEFRVLRVP---NPSS 161

Query: 172 ERGFHRINIYEVMKPPAEVVPGHLIT-RLLDTRLVHHNVTRWETFDVSPAVLRWTREKQP 230
           +R   RI ++++++P   +     I  + L TR        W +FDV+  V  W   ++ 
Sbjct: 162 KRNEQRIELFQILRPDEHIAKQRYIGGKNLPTR----GTAEWLSFDVTDTVREWLLRRES 217

Query: 231 NYGLAIEV---THLHQTR------THQGQHVR---ISRSLPQGSGNWAQLRP-------- 270
           N GL I +    H  Q         H+   ++   +      G G+  +L+         
Sbjct: 218 NLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPH 277

Query: 271 --LLVTFGH--DGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDF-SDVGWNDW 325
             L++   H  D  G    R++RA  +    +   R   +NC    LY+DF  D+GW  W
Sbjct: 278 LILMMIPPHRLDNPGQGGQRKKRALDT----NYCFRNLEENCCVRPLYIDFRQDLGWK-W 332

Query: 326 IVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML 384
           +  P GY A +C G CP+  +     T H+ V  L N++N  +    CCVP +L  +++L
Sbjct: 333 VHEPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTIL 389

Query: 385 -YLDEYDKVVLKNYQEMVVEGCGC 407
            Y+    KV  +    MVV+ C C
Sbjct: 390 YYVGRTPKV--EQLSNMVVKSCKC 411


>gi|13899338 activin beta E [Homo sapiens]
          Length = 350

 Score = 96.3 bits (238), Expect = 4e-20
 Identities = 71/211 (33%), Positives = 95/211 (45%), Gaps = 22/211 (10%)

Query: 202 TRLVHHNVTR--WETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLP 259
           T L  H++T   W T  +  + LR   EK     L ++   L    T  GQ     R L 
Sbjct: 156 TLLAEHHITNLGWHTLTLPSSGLRG--EKSGVLKLQLDCRPLEGNSTVTGQ----PRRLL 209

Query: 260 QGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSD 319
             +G+      L +     G G A  RRR     P             C R   YVDF +
Sbjct: 210 DTAGHQQPFLELKIRANEPGAGRA--RRRTPTCEPA---------TPLCCRRDHYVDFQE 258

Query: 320 VGWNDWIVAPPGYQAFYCHGDCPFPLADH--LNSTNHAIVQTLVNSVNS-SIPKACCVPT 376
           +GW DWI+ P GYQ  YC G CP  LA    + ++ H+ V +L+ + N      +CCVPT
Sbjct: 259 LGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPASTSCCVPT 318

Query: 377 ELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407
               +S+LYLD    VV  +  +MVVE CGC
Sbjct: 319 ARRPLSLLYLDHNGNVVKTDVPDMVVEACGC 349


>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
          Length = 407

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 44/104 (42%), Positives = 62/104 (59%), Gaps = 4/104 (3%)

Query: 308 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLA---DHLNSTNHAIV-QTLVNS 363
           C R   ++DF  +GWNDWI+AP GY   YC G CP  LA      +S + A+V Q  +  
Sbjct: 303 CCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRG 362

Query: 364 VNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407
           +N     +CC+PT+LS +SMLY D+   +V ++   M+VE CGC
Sbjct: 363 LNPGTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 406


>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
           sapiens]
          Length = 442

 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 81/313 (25%), Positives = 137/313 (43%), Gaps = 43/313 (13%)

Query: 125 HLENIPGTSENSAFRFL-FNLSSIPENEV-ISSAELRLFREQVDQGPDWERGFHRINIYE 182
           +L+ IP T     FR + F++S++ +N   +  AE R+FR Q    P       RI +Y+
Sbjct: 142 YLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQ---NPKARVPEQRIELYQ 198

Query: 183 VMKPPAEVVPGHLITRLLDTRLVHHNVT-RWETFDVSPAVLRWTREKQPNYGLAIEVTHL 241
           ++K      P     R +D+++V       W +FDV+ AV  W   K  N G  I + H 
Sbjct: 199 ILKSKDLTSPTQ---RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISL-HC 254

Query: 242 HQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSP------- 294
                    +  I     +    +A +         D +    TR++ + ++P       
Sbjct: 255 PCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLL 314

Query: 295 ---KHHSQRARKKNK--------------NCRRHSLYVDFS-DVGWNDWIVAPPGYQAFY 336
              +  SQ+  ++ K              NC    LY+DF  D+GW  WI  P GY A +
Sbjct: 315 PSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANF 373

Query: 337 CHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML-YLDEYDKVVL 394
           C G CP+  +   + T H+ V +L N++N  +    CCV  +L  +++L Y+ +  K+  
Sbjct: 374 CAGACPYLWS---SDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-- 428

Query: 395 KNYQEMVVEGCGC 407
           +    M+V+ C C
Sbjct: 429 EQLSNMIVKSCKC 441


>gi|5031613 growth differentiation factor 11 precursor [Homo
           sapiens]
          Length = 407

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 64/218 (29%), Positives = 95/218 (43%), Gaps = 33/218 (15%)

Query: 194 HLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVR 253
           H+  R L   L H     W++ D    +  W R+ Q N+G+ I            G  + 
Sbjct: 218 HIRIRSLKIEL-HSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFD------PSGTDLA 270

Query: 254 ISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSP----KHHSQRARKKNKNCR 309
           ++   P   G    L P +           L   +R++R+       HS  +R     C 
Sbjct: 271 VTSLGPGAEG----LHPFMEL-------RVLENTKRSRRNLGLDCDEHSSESR-----CC 314

Query: 310 RHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIP 369
           R+ L VDF   GW DWI+AP  Y+A YC G C +        T H + Q   N   S+ P
Sbjct: 315 RYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMFMQKYPHT-HLVQQA--NPRGSAGP 370

Query: 370 KACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407
             CC PT++S I+MLY ++  +++      MVV+ CGC
Sbjct: 371 --CCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406


>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
          Length = 454

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 36/102 (35%), Positives = 57/102 (55%), Gaps = 1/102 (0%)

Query: 308 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLV-NSVNS 366
           C  H   + FS + W++WIVAP  Y   YC GDCP  +     S  H +VQ ++   ++S
Sbjct: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412

Query: 367 SIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
           S+P+  CVP + S +S+L ++    +  K Y++M+   C CR
Sbjct: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454


>gi|4885259 myostatin [Homo sapiens]
          Length = 375

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 64/196 (32%), Positives = 89/196 (45%), Gaps = 24/196 (12%)

Query: 212 WETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPL 271
           W++ DV   +  W   KQP   L IE+  L +     G  + ++   P   G    L P 
Sbjct: 203 WQSIDVKTVLQNWL--KQPESNLGIEIKALDEN----GHDLAVTFPGPGEDG----LNPF 252

Query: 272 LVTFGHDGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPG 331
           L     D    +   RR        HS  +R     C R+ L VDF   GW DWI+AP  
Sbjct: 253 LEVKVTDTPKRS---RRDFGLDCDEHSTESR-----CCRYPLTVDFEAFGW-DWIIAPKR 303

Query: 332 YQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDK 391
           Y+A YC G+C F        T H + Q   N   S+ P  CC PT++S I+MLY +  ++
Sbjct: 304 YKANYCSGECEFVFLQKYPHT-HLVHQA--NPRGSAGP--CCTPTKMSPINMLYFNGKEQ 358

Query: 392 VVLKNYQEMVVEGCGC 407
           ++      MVV+ CGC
Sbjct: 359 IIYGKIPAMVVDRCGC 374


>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
           sapiens]
          Length = 414

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 80/309 (25%), Positives = 134/309 (43%), Gaps = 43/309 (13%)

Query: 129 IPGTSENSAFRFL-FNLSSIPENEV-ISSAELRLFREQVDQGPDWERGFHRINIYEVMKP 186
           IP T     FR + F++S++ +N   +  AE R+FR Q    P       RI +Y+++K 
Sbjct: 118 IPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQ---NPKARVPEQRIELYQILKS 174

Query: 187 PAEVVPGHLITRLLDTRLVHHNVT-RWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTR 245
                P     R +D+++V       W +FDV+ AV  W   K  N G  I + H     
Sbjct: 175 KDLTSPTQ---RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISL-HCPCCT 230

Query: 246 THQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSP----------K 295
                +  I     +    +A +         D +    TR++ + ++P          +
Sbjct: 231 FVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYR 290

Query: 296 HHSQRARKKNK--------------NCRRHSLYVDFS-DVGWNDWIVAPPGYQAFYCHGD 340
             SQ+  ++ K              NC    LY+DF  D+GW  WI  P GY A +C G 
Sbjct: 291 LESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGA 349

Query: 341 CPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML-YLDEYDKVVLKNYQ 398
           CP+  +   + T H+ V +L N++N  +    CCV  +L  +++L Y+ +  K+  +   
Sbjct: 350 CPYLWS---SDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI--EQLS 404

Query: 399 EMVVEGCGC 407
            M+V+ C C
Sbjct: 405 NMIVKSCKC 413


>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
          Length = 352

 Score = 82.8 bits (203), Expect = 5e-16
 Identities = 44/138 (31%), Positives = 68/138 (49%), Gaps = 9/138 (6%)

Query: 279 GRGHALTRRRRAKRSPKHHSQR----ARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQA 334
           G  H      R +   KH   R     +  ++ C R   +VDF ++GW+DWI+ P GY  
Sbjct: 214 GAAHRPFVAARVRVGGKHQIHRRGIDCQGGSRMCCRQEFFVDFREIGWHDWIIQPEGYAM 273

Query: 335 FYCHGDCPFPLA--DHLNSTNHAIVQTLV---NSVNSSIPKACCVPTELSAISMLYLDEY 389
            +C G CP  +A    + ++ H  V  L+    +  ++   +CCVPT    +S+LY D  
Sbjct: 274 NFCIGQCPLHIAGMPGIAASFHTAVLNLLKANTAAGTTGGGSCCVPTARRPLSLLYYDRD 333

Query: 390 DKVVLKNYQEMVVEGCGC 407
             +V  +  +MVVE CGC
Sbjct: 334 SNIVKTDIPDMVVEACGC 351


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,421,250
Number of Sequences: 37866
Number of extensions: 818725
Number of successful extensions: 2186
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2078
Number of HSP's gapped (non-prelim): 65
length of query: 408
length of database: 18,247,518
effective HSP length: 105
effective length of query: 303
effective length of database: 14,271,588
effective search space: 4324291164
effective search space used: 4324291164
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.