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Search of human proteins with 15718708
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
(464 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 935 0.0
gi|15718708 caspase 8 isoform C precursor [Homo sapiens] 935 0.0
gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 925 0.0
gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 925 0.0
gi|15718704 caspase 8 isoform A precursor [Homo sapiens] 918 0.0
gi|15718712 caspase 8 isoform E [Homo sapiens] 353 2e-97
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 296 3e-80
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 285 5e-77
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 233 4e-61
gi|15718698 caspase 7 isoform delta [Homo sapiens] 161 1e-39
gi|15718700 caspase 7 isoform alpha [Homo sapiens] 161 1e-39
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 161 1e-39
gi|14790115 caspase 3 preproprotein [Homo sapiens] 159 7e-39
gi|14790119 caspase 3 preproprotein [Homo sapiens] 159 7e-39
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 139 4e-33
gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1 [... 134 1e-31
gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1 [... 134 1e-31
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens] 129 4e-30
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 119 8e-27
gi|14916485 caspase 6 isoform beta [Homo sapiens] 102 1e-21
gi|6912286 caspase 14 precursor [Homo sapiens] 94 3e-19
gi|187608585 CASP8 and FADD-like apoptosis regulator isoform 2 [... 73 6e-13
gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo sap... 71 2e-12
gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo sap... 71 2e-12
gi|15718702 caspase 7 isoform beta [Homo sapiens] 70 5e-12
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 65 2e-10
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 65 2e-10
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 65 2e-10
gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 56 6e-08
gi|209870073 caspase 5 isoform c [Homo sapiens] 56 6e-08
>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 935 bits (2416), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
Query: 181 FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH 240
FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH
Sbjct: 181 FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH 240
Query: 241 SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL 300
SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL
Sbjct: 241 SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL 300
Query: 301 SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS 360
SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS
Sbjct: 301 SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS 360
Query: 361 EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420
EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR
Sbjct: 361 EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420
Query: 421 GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464
GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 421 GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464
>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 935 bits (2416), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
Query: 181 FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH 240
FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH
Sbjct: 181 FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH 240
Query: 241 SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL 300
SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL
Sbjct: 241 SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL 300
Query: 301 SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS 360
SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS
Sbjct: 301 SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS 360
Query: 361 EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420
EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR
Sbjct: 361 EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420
Query: 421 GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464
GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 421 GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464
>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
Length = 538
Score = 925 bits (2390), Expect = 0.0
Identities = 464/479 (96%), Positives = 464/479 (96%), Gaps = 15/479 (3%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 60 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 119
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 120 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 179
Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 180 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 239
Query: 181 FSK---------------GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 225
FSK GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
Sbjct: 240 FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 299
Query: 226 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 285
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
Sbjct: 300 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 359
Query: 286 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 345
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
Sbjct: 360 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 419
Query: 346 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 405
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
Sbjct: 420 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 479
Query: 406 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 480 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 538
>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
Length = 479
Score = 925 bits (2390), Expect = 0.0
Identities = 464/479 (96%), Positives = 464/479 (96%), Gaps = 15/479 (3%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
Query: 181 FSK---------------GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 225
FSK GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
Sbjct: 181 FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 240
Query: 226 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 285
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
Sbjct: 241 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 300
Query: 286 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 345
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
Sbjct: 301 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 360
Query: 346 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 405
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
Sbjct: 361 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 420
Query: 406 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 421 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 479
>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
Length = 496
Score = 918 bits (2373), Expect = 0.0
Identities = 464/496 (93%), Positives = 464/496 (93%), Gaps = 32/496 (6%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY------------------- 101
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120
Query: 102 -------------RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 148
RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK
Sbjct: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180
Query: 149 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD 208
RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD
Sbjct: 181 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD 240
Query: 209 KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP 268
KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP
Sbjct: 241 KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP 300
Query: 269 HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 328
HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL
Sbjct: 301 HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 360
Query: 329 KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM 388
KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM
Sbjct: 361 KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM 420
Query: 389 ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM 448
ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM
Sbjct: 421 ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM 480
Query: 449 PQPTFTLRKKLVFPSD 464
PQPTFTLRKKLVFPSD
Sbjct: 481 PQPTFTLRKKLVFPSD 496
>gi|15718712 caspase 8 isoform E [Homo sapiens]
Length = 235
Score = 353 bits (905), Expect = 2e-97
Identities = 183/183 (100%), Positives = 183/183 (100%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
Query: 181 FSK 183
FSK
Sbjct: 181 FSK 183
>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
Length = 479
Score = 296 bits (757), Expect = 3e-80
Identities = 185/479 (38%), Positives = 265/479 (55%), Gaps = 42/479 (8%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
FL ELL+ I + LL +LN KEE+ER L P R ++S +R +LY++SE + L+
Sbjct: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134
Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
FLL++ + K +M L +EK+ + E L L+ +C + LL+ I Y
Sbjct: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKY-- 188
Query: 181 FSKGEELCGVMT------ISDSPREQDSESQTLDK----------VYQMKSKPRGYCLII 224
K E+ ++T E++ SQT K VY+M RG C+I+
Sbjct: 189 --KREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPRAAVYRMNRNHRGLCVIV 246
Query: 225 NNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY 284
NNH+F S++DR GTH DA L+ F+ L F + H++ T ++ +L+
Sbjct: 247 NNHSFT----------SLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQ 296
Query: 285 QLMD-HSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ 343
+ H++ DCF+ CIL+HG G +Y +D PI E+ S FT L+CP LA KPK+FFIQ
Sbjct: 297 KCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQ 356
Query: 344 ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEG 403
ACQG+ Q + +E D+ L IP EADFLLG+ATV VS+R+ EG
Sbjct: 357 ACQGEEIQPSVSIEADALNPEQAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEG 412
Query: 404 TWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFP 462
+WYIQSLC L++ PR +DIL+ILT VN +VS + DK+ KQMPQP FTLRKKLVFP
Sbjct: 413 SWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFP 471
>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
Length = 522
Score = 285 bits (730), Expect = 5e-77
Identities = 188/518 (36%), Positives = 270/518 (52%), Gaps = 77/518 (14%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
FL ELL+ I + LL +LN KEE+ER L P R ++S +R +LY++SE + L+
Sbjct: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134
Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDY-- 178
FLL++ + K +M L +EK+ + E L L+ +C + LL+ I Y
Sbjct: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKR 190
Query: 179 ---------------EEFSKGEELCG---VMTISDS-PRE-------------------- 199
E + EEL V T ++ P+E
Sbjct: 191 EKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPS 250
Query: 200 ------QDSESQTLDK--------VYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDR 245
Q + + TL+ VY+M RG C+I+NNH+F S++DR
Sbjct: 251 LVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFT----------SLKDR 300
Query: 246 NGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMD-HSNMDCFICCILSHGD 304
GTH DA L+ F+ L F + H++ T ++ +L+ + H++ DCF+ CIL+HG
Sbjct: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360
Query: 305 KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQP 364
G +Y +D PI E+ S FT L+CP LA KPK+FFIQACQG+ Q + +E D+
Sbjct: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420
Query: 365 YLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDI 424
L IP EADFLLG+ATV VS+R+ EG+WYIQSLC L++ PR +DI
Sbjct: 421 QAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDI 476
Query: 425 LTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFP 462
L+ILT VN +VS + DK+ KQMPQP FTLRKKLVFP
Sbjct: 477 LSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFP 514
>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
Length = 521
Score = 233 bits (593), Expect = 4e-61
Identities = 160/476 (33%), Positives = 237/476 (49%), Gaps = 77/476 (16%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
FL ELL+ I + LL +LN KEE+ER L P R ++S +R +LY++SE + L+
Sbjct: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134
Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDY-- 178
FLL++ + K +M L +EK+ + E L L+ +C + LL+ I Y
Sbjct: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKR 190
Query: 179 ---------------EEFSKGEELCG---VMTISDS-PRE-------------------- 199
E + EEL V T ++ P+E
Sbjct: 191 EKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPS 250
Query: 200 ------QDSESQTLDK--------VYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDR 245
Q + + TL+ VY+M RG C+I+NNH+F S++DR
Sbjct: 251 LVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFT----------SLKDR 300
Query: 246 NGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMD-HSNMDCFICCILSHGD 304
GTH DA L+ F+ L F + H++ T ++ +L+ + H++ DCF+ CIL+HG
Sbjct: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360
Query: 305 KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQP 364
G +Y +D PI E+ S FT L+CP LA KPK+FFIQACQG+ Q + +E D+
Sbjct: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420
Query: 365 YLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420
L IP EADFLLG+ATV VS+R+ EG+WYIQSLC L++ PR
Sbjct: 421 QAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 472
>gi|15718698 caspase 7 isoform delta [Homo sapiens]
Length = 336
Score = 161 bits (407), Expect = 1e-39
Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)
Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++
Sbjct: 93 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 145
Query: 271 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 330
DC+ ++ ++LK DH+N CF C +LSHG++ +IYG DG PI +LT+ F G +C
Sbjct: 146 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 204
Query: 331 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 390
+L KPK+FFIQAC+G GI ++ P + D ++P+ + IP EADFL +T
Sbjct: 205 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 258
Query: 391 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 444
V S+R+P G+W++Q+LC L E + +I+ ILT VN +E + D +
Sbjct: 259 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 317
Query: 445 GKQMPQPTFTLRKKLVF 461
KQ+P L K+L F
Sbjct: 318 KKQIPCVVSMLTKELYF 334
>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
Length = 303
Score = 161 bits (407), Expect = 1e-39
Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)
Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++
Sbjct: 60 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112
Query: 271 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 330
DC+ ++ ++LK DH+N CF C +LSHG++ +IYG DG PI +LT+ F G +C
Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171
Query: 331 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 390
+L KPK+FFIQAC+G GI ++ P + D ++P+ + IP EADFL +T
Sbjct: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225
Query: 391 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 444
V S+R+P G+W++Q+LC L E + +I+ ILT VN +E + D +
Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284
Query: 445 GKQMPQPTFTLRKKLVF 461
KQ+P L K+L F
Sbjct: 285 KKQIPCVVSMLTKELYF 301
>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
Length = 303
Score = 161 bits (407), Expect = 1e-39
Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)
Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++
Sbjct: 60 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112
Query: 271 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 330
DC+ ++ ++LK DH+N CF C +LSHG++ +IYG DG PI +LT+ F G +C
Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171
Query: 331 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 390
+L KPK+FFIQAC+G GI ++ P + D ++P+ + IP EADFL +T
Sbjct: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225
Query: 391 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 444
V S+R+P G+W++Q+LC L E + +I+ ILT VN +E + D +
Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284
Query: 445 GKQMPQPTFTLRKKLVF 461
KQ+P L K+L F
Sbjct: 285 KKQIPCVVSMLTKELYF 301
>gi|14790115 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 159 bits (401), Expect = 7e-39
Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)
Query: 206 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
+LD Y+M G C+IINN NF K+ + R+GT +DA L TF L +E
Sbjct: 32 SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84
Query: 266 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 325
++ +D T E+I E+++ DHS F+C +LSHG++GII+GT+G + ++T+ F
Sbjct: 85 VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143
Query: 326 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 385
G +C SL GKPK+F IQAC+G GI ETDS ++ D++ + IP EADFL
Sbjct: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194
Query: 386 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 439
+T S+RN +G+W+IQSLC L++ + + + ILT VN +V+ + D
Sbjct: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253
Query: 440 DKKNMGKQMPQPTFTLRKKLVF 461
+ KQ+P L K+L F
Sbjct: 254 ATFHAKKQIPCIVSMLTKELYF 275
>gi|14790119 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 159 bits (401), Expect = 7e-39
Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)
Query: 206 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
+LD Y+M G C+IINN NF K+ + R+GT +DA L TF L +E
Sbjct: 32 SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84
Query: 266 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 325
++ +D T E+I E+++ DHS F+C +LSHG++GII+GT+G + ++T+ F
Sbjct: 85 VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143
Query: 326 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 385
G +C SL GKPK+F IQAC+G GI ETDS ++ D++ + IP EADFL
Sbjct: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194
Query: 386 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 439
+T S+RN +G+W+IQSLC L++ + + + ILT VN +V+ + D
Sbjct: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253
Query: 440 DKKNMGKQMPQPTFTLRKKLVF 461
+ KQ+P L K+L F
Sbjct: 254 ATFHAKKQIPCIVSMLTKELYF 275
>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
Length = 416
Score = 139 bits (351), Expect = 4e-33
Identities = 91/276 (32%), Positives = 134/276 (48%), Gaps = 34/276 (12%)
Query: 208 DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIK 267
D Y + +P G+CLIINN NF + +R R G+++D L F LHF ++
Sbjct: 150 DLAYILSMEPCGHCLIINNVNFCRES-------GLRTRTGSNIDCEKLRRRFSSLHFMVE 202
Query: 268 PHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDK-------GIIYGTDGQEAPIYE 320
D T +++ L DH +DC + ILSHG + G +YGTDG + +
Sbjct: 203 VKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEK 262
Query: 321 LTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ------------PYLEM 368
+ + F G CPSL GKPK+FFIQAC G+ G V + S E P+ E
Sbjct: 263 IVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEG 322
Query: 369 DLSSPQTRYI---PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDIL 425
+ Q I P +D + +T VS+R+P G+WY+++L + E+ +D+
Sbjct: 323 LRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL-DDIFEQWAHSEDLQ 381
Query: 426 TILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVF 461
++L V+N K + KQMP LRKKL F
Sbjct: 382 SLL----LRVANAVSVKGIYKQMPGCFNFLRKKLFF 413
>gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1
[Homo sapiens]
Length = 480
Score = 134 bits (338), Expect = 1e-31
Identities = 129/503 (25%), Positives = 226/503 (44%), Gaps = 81/503 (16%)
Query: 7 LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
++ + E LD+++ L FL D ++D L + L+E+ L +L+ ELL
Sbjct: 6 IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59
Query: 67 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
+R+ R DLL L ++ +E L +S YRV++ +I E++ +S++ S FL+++
Sbjct: 60 YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118
Query: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKG- 184
+ + K+ + + LD+ +E+EK ++ +LD+L++ I++ LK I Y++ +G
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178
Query: 185 -----------------------------------EELCGVMTISDSPREQDSES---QT 206
+E G Q+SE+ Q+
Sbjct: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238
Query: 207 L-DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
+ ++ Y+MKSKP G CLII+ N T L L TF L +E
Sbjct: 239 IPEERYKMKSKPLGICLIIDCIG-----------------NETEL----LRDTFTSLGYE 277
Query: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEA--PIYELT 322
++ ++ I +IL + M +H + D F+C ++S G +YG D + P++ +
Sbjct: 278 VQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIR 337
Query: 323 SQFTGLKCPSLAGKPKVFFIQ--ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPD 380
F G CP LAGKPK+FFIQ + +E D +E +
Sbjct: 338 RMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHR 397
Query: 381 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN---YEVSN 437
EADF + T + + ++ + + Y+Q L Q LR+ R +L + E+N Y+ ++
Sbjct: 398 EADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNS 455
Query: 438 KDDKKNMGKQMPQPTFTLRKKLV 460
+ K K TLRKKL+
Sbjct: 456 RVSAKE--KYYVWLQHTLRKKLI 476
>gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1
[Homo sapiens]
Length = 480
Score = 134 bits (338), Expect = 1e-31
Identities = 129/503 (25%), Positives = 226/503 (44%), Gaps = 81/503 (16%)
Query: 7 LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
++ + E LD+++ L FL D ++D L + L+E+ L +L+ ELL
Sbjct: 6 IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59
Query: 67 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
+R+ R DLL L ++ +E L +S YRV++ +I E++ +S++ S FL+++
Sbjct: 60 YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118
Query: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKG- 184
+ + K+ + + LD+ +E+EK ++ +LD+L++ I++ LK I Y++ +G
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178
Query: 185 -----------------------------------EELCGVMTISDSPREQDSES---QT 206
+E G Q+SE+ Q+
Sbjct: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238
Query: 207 L-DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
+ ++ Y+MKSKP G CLII+ N T L L TF L +E
Sbjct: 239 IPEERYKMKSKPLGICLIIDCIG-----------------NETEL----LRDTFTSLGYE 277
Query: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEA--PIYELT 322
++ ++ I +IL + M +H + D F+C ++S G +YG D + P++ +
Sbjct: 278 VQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIR 337
Query: 323 SQFTGLKCPSLAGKPKVFFIQ--ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPD 380
F G CP LAGKPK+FFIQ + +E D +E +
Sbjct: 338 RMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHR 397
Query: 381 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN---YEVSN 437
EADF + T + + ++ + + Y+Q L Q LR+ R +L + E+N Y+ ++
Sbjct: 398 EADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNS 455
Query: 438 KDDKKNMGKQMPQPTFTLRKKLV 460
+ K K TLRKKL+
Sbjct: 456 RVSAKE--KYYVWLQHTLRKKLI 476
>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
Length = 293
Score = 129 bits (325), Expect = 4e-30
Identities = 94/267 (35%), Positives = 135/267 (50%), Gaps = 31/267 (11%)
Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
Y+M + RG LI N+ F ++ +R GT D LT F +L FE+K +
Sbjct: 37 YKMDHRRRGIALIFNHERFFWHL-------TLPERRGTCADRDNLTRRFSDLGFEVKCFN 89
Query: 271 DCTVEQIYEILKIYQL--MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 328
D E++ +LKI+++ + H++ DCF+C LSHG+ IY D + I LT F G
Sbjct: 90 DLKAEEL--LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGD 146
Query: 329 KCPSLAGKPKVFFIQACQGDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPD 380
KC SL GKPK+F IQAC+G+ Q +PV +T+ + E+D +S T +P
Sbjct: 147 KCHSLVGKPKIFIIQACRGN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPA 202
Query: 381 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN--- 437
ADFL+ + S+R G+WYIQ LC+ L + + +LT VN +VS
Sbjct: 203 GADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRV 261
Query: 438 ---KDDKKNMGKQMPQPTFTLRKKLVF 461
KD KQ+P L KKL F
Sbjct: 262 DFCKDPSAIGKKQVPCFASMLTKKLHF 288
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 119 bits (297), Expect = 8e-27
Identities = 74/237 (31%), Positives = 122/237 (51%), Gaps = 18/237 (7%)
Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
Y+++S+PRG L+++N +F +E + R+G +D L T F+ L +++
Sbjct: 192 YRLQSRPRGLALVLSNVHFTGEKE-------LEFRSGGDVDHSTLVTLFKLLGYDVHVLC 244
Query: 271 DCTVEQIYEILKIY-QLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLK 329
D T +++ E L+ + QL H D I +LSHG +G IYG DG+ + E+ F
Sbjct: 245 DQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNAN 304
Query: 330 CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSS------PQTRYIPDEAD 383
CPSL KPK+FFIQAC+GD +G+ + + S P+ R +P +D
Sbjct: 305 CPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMR-LPTRSD 363
Query: 384 FLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER-CPRGDDILTILTEVNYEVSNKD 439
+ G A + + RN G+WYI++L Q ER C + +L +VN + +++
Sbjct: 364 MICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM--HVADMLVKVNALIKDRE 418
>gi|14916485 caspase 6 isoform beta [Homo sapiens]
Length = 204
Score = 102 bits (253), Expect = 1e-21
Identities = 70/189 (37%), Positives = 96/189 (50%), Gaps = 20/189 (10%)
Query: 287 MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQ 346
+ H++ DCF+C LSHG+ IY D + I LT F G KC SL GKPK+F IQAC+
Sbjct: 17 VSHADADCFVCVFLSHGEGNHIYAYDAK-IEIQTLTGLFKGDKCHSLVGKPKIFIIQACR 75
Query: 347 GDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYR 398
G+ Q +PV +T+ + E+D +S T +P ADFL+ + S+R
Sbjct: 76 GN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPAGADFLMCYSVAEGYYSHR 131
Query: 399 NPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN------KDDKKNMGKQMPQPT 452
G+WYIQ LC+ L + + +LT VN +VS KD KQ+P
Sbjct: 132 ETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFA 190
Query: 453 FTLRKKLVF 461
L KKL F
Sbjct: 191 SMLTKKLHF 199
>gi|6912286 caspase 14 precursor [Homo sapiens]
Length = 242
Score = 93.6 bits (231), Expect = 3e-19
Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 14/220 (6%)
Query: 245 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMD---CFICCILS 301
R G+ D AL F +L FE D T EQ E L+ +Q S D C +++
Sbjct: 29 REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88
Query: 302 HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSE 361
HG +G + G DG+ + L C +L KPKV+ IQAC+G+ G V D
Sbjct: 89 HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDE- 147
Query: 362 EQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRG 421
+ + SPQT IP D L +TV ++YR+ +G+ +IQ+L + R
Sbjct: 148 ---IVMVIKDSPQT--IPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK---RK 199
Query: 422 DDILTILTEVNYEVSNKD--DKKNMGKQMPQPTFTLRKKL 459
IL +LTEV ++ + + K P+ TLRK+L
Sbjct: 200 GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRL 239
>gi|187608585 CASP8 and FADD-like apoptosis regulator isoform 2
[Homo sapiens]
Length = 221
Score = 72.8 bits (177), Expect = 6e-13
Identities = 49/179 (27%), Positives = 98/179 (54%), Gaps = 8/179 (4%)
Query: 7 LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
++ + E LD+++ L FL D ++D L + L+E+ L +L+ ELL
Sbjct: 6 IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59
Query: 67 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
+R+ R DLL L ++ +E L +S YRV++ +I E++ +S++ S FL+++
Sbjct: 60 YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118
Query: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKG 184
+ + K+ + + LD+ +E+EK ++ +LD+L++ I++ LK I Y++ +G
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQG 177
Score = 45.8 bits (107), Expect = 8e-05
Identities = 32/122 (26%), Positives = 62/122 (50%), Gaps = 9/122 (7%)
Query: 2 DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF 61
D+ + +IGE LD D++SL FL DY+ + K K L L L++ ++ L
Sbjct: 92 DYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDL 151
Query: 62 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFK 121
L++ L I+R+D L T+ ++ ++ +Q G ++YR +L ++ + +F+
Sbjct: 152 LEKCLKNIHRID-----LKTKIQKYKQSVQGAG----TSYRNVLQAAIQKSLKDPSNNFR 202
Query: 122 FL 123
+
Sbjct: 203 MI 204
>gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo
sapiens]
Length = 432
Score = 70.9 bits (172), Expect = 2e-12
Identities = 76/262 (29%), Positives = 118/262 (45%), Gaps = 37/262 (14%)
Query: 227 HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-Q 285
++ +KAR + L I+ R G D AL L FE D T + E L + +
Sbjct: 175 YDLSKARAAL-LLAVIQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFRE 233
Query: 286 LMD--HSNMDCFICCILSHGD-KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI 342
+D + C + +++HG +G + G DGQE L + + +C L G+PK+F +
Sbjct: 234 QLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQPEALMQELS--RCQVLQGRPKIFLL 291
Query: 343 QACQGDNYQKGI--------------PVETDSEE---QPYLEMDLSSPQTRYIP----DE 381
QAC+G N G+ P S Q Y E SS R P D+
Sbjct: 292 QACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQGSS--CRGTPPGSSDQ 349
Query: 382 ADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD-- 439
AD L + V+YR+ +G+ +IQ+L + LR G D+L +LTEVN V ++
Sbjct: 350 ADILTVYSAAEGYVAYRDD-KGSDFIQTLVEVLRAN--PGRDLLELLTEVNRRVCEQEVL 406
Query: 440 --DKKNMGKQMPQPTFTLRKKL 459
D + K + +LR++L
Sbjct: 407 GPDCDELRKACLEIRSSLRRRL 428
>gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo
sapiens]
Length = 432
Score = 70.9 bits (172), Expect = 2e-12
Identities = 76/262 (29%), Positives = 118/262 (45%), Gaps = 37/262 (14%)
Query: 227 HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-Q 285
++ +KAR + L I+ R G D AL L FE D T + E L + +
Sbjct: 175 YDLSKARAAL-LLAVIQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFRE 233
Query: 286 LMD--HSNMDCFICCILSHGD-KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI 342
+D + C + +++HG +G + G DGQE L + + +C L G+PK+F +
Sbjct: 234 QLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQPEALMQELS--RCQVLQGRPKIFLL 291
Query: 343 QACQGDNYQKGI--------------PVETDSEE---QPYLEMDLSSPQTRYIP----DE 381
QAC+G N G+ P S Q Y E SS R P D+
Sbjct: 292 QACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQGSS--CRGTPPGSSDQ 349
Query: 382 ADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD-- 439
AD L + V+YR+ +G+ +IQ+L + LR G D+L +LTEVN V ++
Sbjct: 350 ADILTVYSAAEGYVAYRDD-KGSDFIQTLVEVLRAN--PGRDLLELLTEVNRRVCEQEVL 406
Query: 440 --DKKNMGKQMPQPTFTLRKKL 459
D + K + +LR++L
Sbjct: 407 GPDCDELRKACLEIRSSLRRRL 428
>gi|15718702 caspase 7 isoform beta [Homo sapiens]
Length = 253
Score = 69.7 bits (169), Expect = 5e-12
Identities = 36/97 (37%), Positives = 54/97 (55%), Gaps = 7/97 (7%)
Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++
Sbjct: 60 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112
Query: 271 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI 307
DC+ ++ ++LK DH+N CF C +LSHG++ +
Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENM 149
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 64.7 bits (156), Expect = 2e-10
Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%)
Query: 214 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 273
KS LII N F SI R G +D +T + L + + + T
Sbjct: 65 KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 114
Query: 274 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 329
+ L+ + +H D +SHG + GI ++ P I +L + F L
Sbjct: 115 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 174
Query: 330 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 382
CPSL KPKV IQAC+GD+ P ++ + +LS P T D+A
Sbjct: 175 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 229
Query: 383 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 439
DF+ ++ + VS+R+P G+ +I L + ++E D+ I +V + D
Sbjct: 230 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 288
Query: 440 DKKNM 444
+ M
Sbjct: 289 GRAQM 293
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 64.7 bits (156), Expect = 2e-10
Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%)
Query: 214 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 273
KS LII N F SI R G +D +T + L + + + T
Sbjct: 158 KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 207
Query: 274 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 329
+ L+ + +H D +SHG + GI ++ P I +L + F L
Sbjct: 208 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 267
Query: 330 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 382
CPSL KPKV IQAC+GD+ P ++ + +LS P T D+A
Sbjct: 268 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 322
Query: 383 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 439
DF+ ++ + VS+R+P G+ +I L + ++E D+ I +V + D
Sbjct: 323 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 381
Query: 440 DKKNM 444
+ M
Sbjct: 382 GRAQM 386
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 64.7 bits (156), Expect = 2e-10
Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%)
Query: 214 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 273
KS LII N F SI R G +D +T + L + + + T
Sbjct: 137 KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 186
Query: 274 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 329
+ L+ + +H D +SHG + GI ++ P I +L + F L
Sbjct: 187 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 246
Query: 330 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 382
CPSL KPKV IQAC+GD+ P ++ + +LS P T D+A
Sbjct: 247 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 301
Query: 383 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 439
DF+ ++ + VS+R+P G+ +I L + ++E D+ I +V + D
Sbjct: 302 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 360
Query: 440 DKKNM 444
+ M
Sbjct: 361 GRAQM 365
>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
Length = 447
Score = 56.2 bits (134), Expect = 6e-08
Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%)
Query: 208 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
D++Y +K + R LII N F + +P RNG H D + + L +
Sbjct: 193 DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 242
Query: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 320
+ + T + +L+ + +H + D ++SHG I GT ++ +Y+
Sbjct: 243 VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 302
Query: 321 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 372
Q F C SL KPKV +QAC+G+ + + P S+ LE D
Sbjct: 303 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 359
Query: 373 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 410
I +E DF+ ++ + VS+R+ G+ +I L
Sbjct: 360 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 396
>gi|209870073 caspase 5 isoform c [Homo sapiens]
Length = 292
Score = 56.2 bits (134), Expect = 6e-08
Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%)
Query: 208 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
D++Y +K + R LII N F + +P RNG H D + + L +
Sbjct: 38 DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 87
Query: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 320
+ + T + +L+ + +H + D ++SHG I GT ++ +Y+
Sbjct: 88 VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 147
Query: 321 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 372
Q F C SL KPKV +QAC+G+ + + P S+ LE D
Sbjct: 148 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 204
Query: 373 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 410
I +E DF+ ++ + VS+R+ G+ +I L
Sbjct: 205 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 241
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,653,513
Number of Sequences: 37866
Number of extensions: 823947
Number of successful extensions: 2242
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 2090
Number of HSP's gapped (non-prelim): 103
length of query: 464
length of database: 18,247,518
effective HSP length: 106
effective length of query: 358
effective length of database: 14,233,722
effective search space: 5095672476
effective search space used: 5095672476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.