Search of human proteins with 15718706

Search of human proteins with 15718706

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
         (479 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|122056476 caspase 8 isoform G precursor [Homo sapiens]             964   0.0  
gi|15718706 caspase 8 isoform B precursor [Homo sapiens]              964   0.0  
gi|122056474 caspase 8 isoform C precursor [Homo sapiens]             925   0.0  
gi|15718708 caspase 8 isoform C precursor [Homo sapiens]              925   0.0  
gi|15718704 caspase 8 isoform A precursor [Homo sapiens]              908   0.0  
gi|15718712 caspase 8 isoform E [Homo sapiens]                        382   e-106
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]         300   2e-81
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]         291   9e-79
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]         238   7e-63
gi|15718698 caspase 7 isoform delta [Homo sapiens]                    161   1e-39
gi|15718700 caspase 7 isoform alpha [Homo sapiens]                    161   1e-39
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]           161   1e-39
gi|14790115 caspase 3 preproprotein [Homo sapiens]                    159   7e-39
gi|14790119 caspase 3 preproprotein [Homo sapiens]                    159   7e-39
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]      139   4e-33
gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1 [...   139   7e-33
gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1 [...   139   7e-33
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]      129   4e-30
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]          119   8e-27
gi|14916485 caspase 6 isoform beta [Homo sapiens]                     102   1e-21
gi|6912286 caspase 14 precursor [Homo sapiens]                         94   4e-19
gi|187608585 CASP8 and FADD-like apoptosis regulator isoform 2 [...    72   1e-12
gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo sap...    71   2e-12
gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo sap...    71   2e-12
gi|15718702 caspase 7 isoform beta [Homo sapiens]                      70   6e-12
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]           65   1e-10
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]           65   1e-10
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]             65   1e-10
gi|209870079 caspase 5 isoform f precursor [Homo sapiens]              59   7e-09
gi|209870071 caspase 5 isoform b precursor [Homo sapiens]              59   7e-09

>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
          Length = 538

 Score =  964 bits (2491), Expect = 0.0
 Identities = 479/479 (100%), Positives = 479/479 (100%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 60  MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 119

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 120 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 179

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 180 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 239

Query: 181 FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 240
           FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
Sbjct: 240 FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 299

Query: 241 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 300
           NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
Sbjct: 300 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 359

Query: 301 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 360
           LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
Sbjct: 360 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 419

Query: 361 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 420
           QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
Sbjct: 420 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 479

Query: 421 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 479
           YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 480 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 538


>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
          Length = 479

 Score =  964 bits (2491), Expect = 0.0
 Identities = 479/479 (100%), Positives = 479/479 (100%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180

Query: 181 FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 240
           FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
Sbjct: 181 FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 240

Query: 241 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 300
           NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
Sbjct: 241 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 300

Query: 301 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 360
           LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
Sbjct: 301 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 360

Query: 361 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 420
           QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
Sbjct: 361 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 420

Query: 421 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 479
           YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 421 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 479


>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score =  925 bits (2390), Expect = 0.0
 Identities = 464/479 (96%), Positives = 464/479 (96%), Gaps = 15/479 (3%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180

Query: 181 FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 240
           FSK               GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
Sbjct: 181 FSK---------------GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 225

Query: 241 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 300
           NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
Sbjct: 226 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 285

Query: 301 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 360
           LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
Sbjct: 286 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 345

Query: 361 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 420
           QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
Sbjct: 346 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 405

Query: 421 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 479
           YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 406 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464


>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score =  925 bits (2390), Expect = 0.0
 Identities = 464/479 (96%), Positives = 464/479 (96%), Gaps = 15/479 (3%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180

Query: 181 FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 240
           FSK               GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
Sbjct: 181 FSK---------------GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 225

Query: 241 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 300
           NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
Sbjct: 226 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 285

Query: 301 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 360
           LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
Sbjct: 286 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 345

Query: 361 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 420
           QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
Sbjct: 346 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 405

Query: 421 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 479
           YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 406 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464


>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
          Length = 496

 Score =  908 bits (2347), Expect = 0.0
 Identities = 464/511 (90%), Positives = 464/511 (90%), Gaps = 47/511 (9%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY------------------- 101
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY                   
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120

Query: 102 -------------RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 148
                        RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK
Sbjct: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180

Query: 149 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTI 208
           RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSK               GEELCGVMTI
Sbjct: 181 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSK---------------GEELCGVMTI 225

Query: 209 SDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAG 268
           SDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAG
Sbjct: 226 SDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAG 285

Query: 269 ALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDG 328
           ALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDG
Sbjct: 286 ALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDG 345

Query: 329 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSP 388
           QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSP
Sbjct: 346 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSP 405

Query: 389 QTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNY 448
           QTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNY
Sbjct: 406 QTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNY 465

Query: 449 EVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 479
           EVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 466 EVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 496


>gi|15718712 caspase 8 isoform E [Homo sapiens]
          Length = 235

 Score =  382 bits (980), Expect = e-106
 Identities = 198/198 (100%), Positives = 198/198 (100%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180

Query: 181 FSKERSSSLEGSPDEFSN 198
           FSKERSSSLEGSPDEFSN
Sbjct: 181 FSKERSSSLEGSPDEFSN 198


>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
          Length = 479

 Score =  300 bits (768), Expect = 2e-81
 Identities = 184/483 (38%), Positives = 271/483 (56%), Gaps = 35/483 (7%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           + F   L  I   L  +D+ +LKFL +  +P +K E    A  +F+ L  + +L E +  
Sbjct: 18  VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FL ELL+ I +  LL  +LN  KEE+ER L  P R ++S +R +LY++SE +    L+  
Sbjct: 78  FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
            FLL++ + K     +M  L     +EK+  + E  L  L+ +C  +   LL+ I   E+
Sbjct: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNI---EK 187

Query: 181 FSKERSSSLEGSP-----DEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGY 235
           + +E++  +   P     + +   EEL     +S +  +   E+     VY+M    RG 
Sbjct: 188 YKREKAIQIVTPPVDKEAESYQGEEEL-----VSQTDVKTFLEALPRAAVYRMNRNHRGL 242

Query: 236 CLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEI 295
           C+I+NNH+F           S++DR GTH DA  L+  F+ L F +  H++ T  ++  +
Sbjct: 243 CVIVNNHSFT----------SLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMV 292

Query: 296 LKIYQLMD-HSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKV 354
           L+  +    H++ DCF+ CIL+HG  G +Y +D    PI E+ S FT L+CP LA KPK+
Sbjct: 293 LQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKL 352

Query: 355 FFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRN 414
           FFIQACQG+  Q  + +E D+         L       IP EADFLLG+ATV   VS+R+
Sbjct: 353 FFIQACQGEEIQPSVSIEADALNPEQAPTSLQDS----IPAEADFLLGLATVPGYVSFRH 408

Query: 415 PAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKL 474
             EG+WYIQSLC  L++  PR +DIL+ILT VN +VS + DK+   KQMPQP FTLRKKL
Sbjct: 409 VEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKL 468

Query: 475 VFP 477
           VFP
Sbjct: 469 VFP 471


>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
          Length = 522

 Score =  291 bits (745), Expect = 9e-79
 Identities = 191/518 (36%), Positives = 270/518 (52%), Gaps = 62/518 (11%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           + F   L  I   L  +D+ +LKFL +  +P +K E    A  +F+ L  + +L E +  
Sbjct: 18  VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FL ELL+ I +  LL  +LN  KEE+ER L  P R ++S +R +LY++SE +    L+  
Sbjct: 78  FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
            FLL++ + K     +M  L     +EK+  + E  L  L+ +C  +   LL+ I  Y+ 
Sbjct: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKR 190

Query: 181 ----------FSKERSSS---------------LEGSPDEF-------SNGEELCGVMTI 208
                       KE  S                LE  P E        SNG         
Sbjct: 191 EKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPS 250

Query: 209 SDSPREQDSESQTLDK--------VYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDR 260
             S   Q + + TL+         VY+M    RG C+I+NNH+F           S++DR
Sbjct: 251 LVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFT----------SLKDR 300

Query: 261 NGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMD-HSNMDCFICCILSHGD 319
            GTH DA  L+  F+ L F +  H++ T  ++  +L+  +    H++ DCF+ CIL+HG 
Sbjct: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360

Query: 320 KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQP 379
            G +Y +D    PI E+ S FT L+CP LA KPK+FFIQACQG+  Q  + +E D+    
Sbjct: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420

Query: 380 YLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDI 439
                L       IP EADFLLG+ATV   VS+R+  EG+WYIQSLC  L++  PR +DI
Sbjct: 421 QAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDI 476

Query: 440 LTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFP 477
           L+ILT VN +VS + DK+   KQMPQP FTLRKKLVFP
Sbjct: 477 LSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFP 514


>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
          Length = 521

 Score =  238 bits (608), Expect = 7e-63
 Identities = 163/476 (34%), Positives = 237/476 (49%), Gaps = 62/476 (13%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           + F   L  I   L  +D+ +LKFL +  +P +K E    A  +F+ L  + +L E +  
Sbjct: 18  VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FL ELL+ I +  LL  +LN  KEE+ER L  P R ++S +R +LY++SE +    L+  
Sbjct: 78  FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
            FLL++ + K     +M  L     +EK+  + E  L  L+ +C  +   LL+ I  Y+ 
Sbjct: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKR 190

Query: 181 ----------FSKERSSS---------------LEGSPDEF-------SNGEELCGVMTI 208
                       KE  S                LE  P E        SNG         
Sbjct: 191 EKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPS 250

Query: 209 SDSPREQDSESQTLDK--------VYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDR 260
             S   Q + + TL+         VY+M    RG C+I+NNH+F           S++DR
Sbjct: 251 LVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFT----------SLKDR 300

Query: 261 NGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMD-HSNMDCFICCILSHGD 319
            GTH DA  L+  F+ L F +  H++ T  ++  +L+  +    H++ DCF+ CIL+HG 
Sbjct: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360

Query: 320 KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQP 379
            G +Y +D    PI E+ S FT L+CP LA KPK+FFIQACQG+  Q  + +E D+    
Sbjct: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420

Query: 380 YLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 435
                L       IP EADFLLG+ATV   VS+R+  EG+WYIQSLC  L++  PR
Sbjct: 421 QAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 472


>gi|15718698 caspase 7 isoform delta [Homo sapiens]
          Length = 336

 Score =  161 bits (407), Expect = 1e-39
 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)

Query: 226 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 285
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 93  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 145

Query: 286 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 345
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +IYG DG   PI +LT+ F G +C
Sbjct: 146 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 204

Query: 346 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 405
            +L  KPK+FFIQAC+G     GI     ++  P  + D ++P+ + IP EADFL   +T
Sbjct: 205 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 258

Query: 406 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 459
           V    S+R+P  G+W++Q+LC  L E   +  +I+ ILT VN      +E  + D   + 
Sbjct: 259 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 317

Query: 460 GKQMPQPTFTLRKKLVF 476
            KQ+P     L K+L F
Sbjct: 318 KKQIPCVVSMLTKELYF 334


>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
          Length = 303

 Score =  161 bits (407), Expect = 1e-39
 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)

Query: 226 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 285
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 60  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112

Query: 286 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 345
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +IYG DG   PI +LT+ F G +C
Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171

Query: 346 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 405
            +L  KPK+FFIQAC+G     GI     ++  P  + D ++P+ + IP EADFL   +T
Sbjct: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225

Query: 406 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 459
           V    S+R+P  G+W++Q+LC  L E   +  +I+ ILT VN      +E  + D   + 
Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284

Query: 460 GKQMPQPTFTLRKKLVF 476
            KQ+P     L K+L F
Sbjct: 285 KKQIPCVVSMLTKELYF 301


>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
          Length = 303

 Score =  161 bits (407), Expect = 1e-39
 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)

Query: 226 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 285
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 60  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112

Query: 286 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 345
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +IYG DG   PI +LT+ F G +C
Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171

Query: 346 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 405
            +L  KPK+FFIQAC+G     GI     ++  P  + D ++P+ + IP EADFL   +T
Sbjct: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225

Query: 406 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 459
           V    S+R+P  G+W++Q+LC  L E   +  +I+ ILT VN      +E  + D   + 
Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284

Query: 460 GKQMPQPTFTLRKKLVF 476
            KQ+P     L K+L F
Sbjct: 285 KKQIPCVVSMLTKELYF 301


>gi|14790115 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score =  159 bits (401), Expect = 7e-39
 Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)

Query: 221 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 280
           +LD  Y+M     G C+IINN NF K+         +  R+GT +DA  L  TF  L +E
Sbjct: 32  SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84

Query: 281 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 340
           ++  +D T E+I E+++     DHS    F+C +LSHG++GII+GT+G    + ++T+ F
Sbjct: 85  VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143

Query: 341 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 400
            G +C SL GKPK+F IQAC+G     GI  ETDS     ++ D++  +   IP EADFL
Sbjct: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194

Query: 401 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 454
              +T     S+RN  +G+W+IQSLC  L++   +  + + ILT VN +V+ +      D
Sbjct: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253

Query: 455 DKKNMGKQMPQPTFTLRKKLVF 476
              +  KQ+P     L K+L F
Sbjct: 254 ATFHAKKQIPCIVSMLTKELYF 275


>gi|14790119 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score =  159 bits (401), Expect = 7e-39
 Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)

Query: 221 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 280
           +LD  Y+M     G C+IINN NF K+         +  R+GT +DA  L  TF  L +E
Sbjct: 32  SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84

Query: 281 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 340
           ++  +D T E+I E+++     DHS    F+C +LSHG++GII+GT+G    + ++T+ F
Sbjct: 85  VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143

Query: 341 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 400
            G +C SL GKPK+F IQAC+G     GI  ETDS     ++ D++  +   IP EADFL
Sbjct: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194

Query: 401 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 454
              +T     S+RN  +G+W+IQSLC  L++   +  + + ILT VN +V+ +      D
Sbjct: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253

Query: 455 DKKNMGKQMPQPTFTLRKKLVF 476
              +  KQ+P     L K+L F
Sbjct: 254 ATFHAKKQIPCIVSMLTKELYF 275


>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
          Length = 416

 Score =  139 bits (351), Expect = 4e-33
 Identities = 91/276 (32%), Positives = 134/276 (48%), Gaps = 34/276 (12%)

Query: 223 DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIK 282
           D  Y +  +P G+CLIINN NF +          +R R G+++D   L   F  LHF ++
Sbjct: 150 DLAYILSMEPCGHCLIINNVNFCRES-------GLRTRTGSNIDCEKLRRRFSSLHFMVE 202

Query: 283 PHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDK-------GIIYGTDGQEAPIYE 335
              D T +++   L      DH  +DC +  ILSHG +       G +YGTDG    + +
Sbjct: 203 VKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEK 262

Query: 336 LTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ------------PYLEM 383
           + + F G  CPSL GKPK+FFIQAC G+    G  V + S E             P+ E 
Sbjct: 263 IVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEG 322

Query: 384 DLSSPQTRYI---PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDIL 440
             +  Q   I   P  +D  +  +T    VS+R+P  G+WY+++L   + E+    +D+ 
Sbjct: 323 LRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL-DDIFEQWAHSEDLQ 381

Query: 441 TILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVF 476
           ++L      V+N    K + KQMP     LRKKL F
Sbjct: 382 SLL----LRVANAVSVKGIYKQMPGCFNFLRKKLFF 413


>gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1
           [Homo sapiens]
          Length = 480

 Score =  139 bits (349), Expect = 7e-33
 Identities = 131/503 (26%), Positives = 233/503 (46%), Gaps = 66/503 (13%)

Query: 7   LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
           ++ + E LD+++   L FL  D         ++D L +   L+E+  L   +L+   ELL
Sbjct: 6   IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59

Query: 67  FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
           +R+ R DLL   L   ++ +E  L       +S YRV++ +I E++ +S++ S  FL+++
Sbjct: 60  YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118

Query: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEE----- 180
            + + K+  + + LD+ +E+EK  ++   +LD+L++    I++  LK  I  Y++     
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178

Query: 181 ---FSKERSSSLEGSPDEFSNG-------------EELCGVMTISDSPREQDSES---QT 221
              +     ++++ S  + SN              +E  G          Q+SE+   Q+
Sbjct: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238

Query: 222 L-DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 280
           + ++ Y+MKSKP G CLII+                    N T L    L  TF  L +E
Sbjct: 239 IPEERYKMKSKPLGICLIIDCIG-----------------NETEL----LRDTFTSLGYE 277

Query: 281 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEA--PIYELT 337
           ++     ++  I +IL  +  M +H + D F+C ++S G    +YG D   +  P++ + 
Sbjct: 278 VQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIR 337

Query: 338 SQFTGLKCPSLAGKPKVFFIQ--ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPD 395
             F G  CP LAGKPK+FFIQ         +    +E D      +E          +  
Sbjct: 338 RMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHR 397

Query: 396 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN---YEVSN 452
           EADF   + T +  +  ++ +  + Y+Q L Q LR+   R   +L +  E+N   Y+ ++
Sbjct: 398 EADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNS 455

Query: 453 KDDKKNMGKQMPQPTFTLRKKLV 475
           +   K   K       TLRKKL+
Sbjct: 456 RVSAKE--KYYVWLQHTLRKKLI 476


>gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1
           [Homo sapiens]
          Length = 480

 Score =  139 bits (349), Expect = 7e-33
 Identities = 131/503 (26%), Positives = 233/503 (46%), Gaps = 66/503 (13%)

Query: 7   LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
           ++ + E LD+++   L FL  D         ++D L +   L+E+  L   +L+   ELL
Sbjct: 6   IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59

Query: 67  FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
           +R+ R DLL   L   ++ +E  L       +S YRV++ +I E++ +S++ S  FL+++
Sbjct: 60  YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118

Query: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEE----- 180
            + + K+  + + LD+ +E+EK  ++   +LD+L++    I++  LK  I  Y++     
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178

Query: 181 ---FSKERSSSLEGSPDEFSNG-------------EELCGVMTISDSPREQDSES---QT 221
              +     ++++ S  + SN              +E  G          Q+SE+   Q+
Sbjct: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238

Query: 222 L-DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 280
           + ++ Y+MKSKP G CLII+                    N T L    L  TF  L +E
Sbjct: 239 IPEERYKMKSKPLGICLIIDCIG-----------------NETEL----LRDTFTSLGYE 277

Query: 281 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEA--PIYELT 337
           ++     ++  I +IL  +  M +H + D F+C ++S G    +YG D   +  P++ + 
Sbjct: 278 VQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIR 337

Query: 338 SQFTGLKCPSLAGKPKVFFIQ--ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPD 395
             F G  CP LAGKPK+FFIQ         +    +E D      +E          +  
Sbjct: 338 RMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHR 397

Query: 396 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN---YEVSN 452
           EADF   + T +  +  ++ +  + Y+Q L Q LR+   R   +L +  E+N   Y+ ++
Sbjct: 398 EADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNS 455

Query: 453 KDDKKNMGKQMPQPTFTLRKKLV 475
           +   K   K       TLRKKL+
Sbjct: 456 RVSAKE--KYYVWLQHTLRKKLI 476


>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
          Length = 293

 Score =  129 bits (325), Expect = 4e-30
 Identities = 94/267 (35%), Positives = 135/267 (50%), Gaps = 31/267 (11%)

Query: 226 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 285
           Y+M  + RG  LI N+  F           ++ +R GT  D   LT  F +L FE+K  +
Sbjct: 37  YKMDHRRRGIALIFNHERFFWHL-------TLPERRGTCADRDNLTRRFSDLGFEVKCFN 89

Query: 286 DCTVEQIYEILKIYQL--MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 343
           D   E++  +LKI+++  + H++ DCF+C  LSHG+   IY  D  +  I  LT  F G 
Sbjct: 90  DLKAEEL--LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGD 146

Query: 344 KCPSLAGKPKVFFIQACQGDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPD 395
           KC SL GKPK+F IQAC+G+  Q  +PV        +T+  +    E+D +S  T  +P 
Sbjct: 147 KCHSLVGKPKIFIIQACRGN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPA 202

Query: 396 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN--- 452
            ADFL+  +      S+R    G+WYIQ LC+ L  +     +   +LT VN +VS    
Sbjct: 203 GADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRV 261

Query: 453 ---KDDKKNMGKQMPQPTFTLRKKLVF 476
              KD      KQ+P     L KKL F
Sbjct: 262 DFCKDPSAIGKKQVPCFASMLTKKLHF 288


>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
          Length = 452

 Score =  119 bits (297), Expect = 8e-27
 Identities = 74/237 (31%), Positives = 122/237 (51%), Gaps = 18/237 (7%)

Query: 226 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 285
           Y+++S+PRG  L+++N +F   +E       +  R+G  +D   L T F+ L +++    
Sbjct: 192 YRLQSRPRGLALVLSNVHFTGEKE-------LEFRSGGDVDHSTLVTLFKLLGYDVHVLC 244

Query: 286 DCTVEQIYEILKIY-QLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLK 344
           D T +++ E L+ + QL  H   D  I  +LSHG +G IYG DG+   + E+   F    
Sbjct: 245 DQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNAN 304

Query: 345 CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSS------PQTRYIPDEAD 398
           CPSL  KPK+FFIQAC+GD   +G+  +           + S       P+ R +P  +D
Sbjct: 305 CPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMR-LPTRSD 363

Query: 399 FLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER-CPRGDDILTILTEVNYEVSNKD 454
            + G A +    + RN   G+WYI++L Q   ER C     +  +L +VN  + +++
Sbjct: 364 MICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM--HVADMLVKVNALIKDRE 418


>gi|14916485 caspase 6 isoform beta [Homo sapiens]
          Length = 204

 Score =  102 bits (253), Expect = 1e-21
 Identities = 70/189 (37%), Positives = 96/189 (50%), Gaps = 20/189 (10%)

Query: 302 MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQ 361
           + H++ DCF+C  LSHG+   IY  D +   I  LT  F G KC SL GKPK+F IQAC+
Sbjct: 17  VSHADADCFVCVFLSHGEGNHIYAYDAK-IEIQTLTGLFKGDKCHSLVGKPKIFIIQACR 75

Query: 362 GDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYR 413
           G+  Q  +PV        +T+  +    E+D +S  T  +P  ADFL+  +      S+R
Sbjct: 76  GN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPAGADFLMCYSVAEGYYSHR 131

Query: 414 NPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN------KDDKKNMGKQMPQPT 467
               G+WYIQ LC+ L  +     +   +LT VN +VS       KD      KQ+P   
Sbjct: 132 ETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFA 190

Query: 468 FTLRKKLVF 476
             L KKL F
Sbjct: 191 SMLTKKLHF 199


>gi|6912286 caspase 14 precursor [Homo sapiens]
          Length = 242

 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 14/220 (6%)

Query: 260 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMD---CFICCILS 316
           R G+  D  AL   F +L FE     D T EQ  E L+ +Q    S  D   C    +++
Sbjct: 29  REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88

Query: 317 HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSE 376
           HG +G + G DG+   +  L        C +L  KPKV+ IQAC+G+    G  V  D  
Sbjct: 89  HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDE- 147

Query: 377 EQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRG 436
               + +   SPQT  IP   D L   +TV   ++YR+  +G+ +IQ+L     +   R 
Sbjct: 148 ---IVMVIKDSPQT--IPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK---RK 199

Query: 437 DDILTILTEVNYEVSNKD--DKKNMGKQMPQPTFTLRKKL 474
             IL +LTEV   ++  +   +    K  P+   TLRK+L
Sbjct: 200 GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRL 239


>gi|187608585 CASP8 and FADD-like apoptosis regulator isoform 2
           [Homo sapiens]
          Length = 221

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 51/193 (26%), Positives = 103/193 (53%), Gaps = 15/193 (7%)

Query: 7   LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
           ++ + E LD+++   L FL  D         ++D L +   L+E+  L   +L+   ELL
Sbjct: 6   IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59

Query: 67  FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
           +R+ R DLL   L   ++ +E  L       +S YRV++ +I E++ +S++ S  FL+++
Sbjct: 60  YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118

Query: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKER 185
            + + K+  + + LD+ +E+EK  ++   +LD+L++    I++  LK  I  Y++     
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQ----- 173

Query: 186 SSSLEGSPDEFSN 198
             S++G+   + N
Sbjct: 174 --SVQGAGTSYRN 184



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 32/122 (26%), Positives = 62/122 (50%), Gaps = 9/122 (7%)

Query: 2   DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF 61
           D+   + +IGE LD  D++SL FL  DY+ + K    K  L L   L++  ++    L  
Sbjct: 92  DYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDL 151

Query: 62  LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFK 121
           L++ L  I+R+D     L T+ ++ ++ +Q  G    ++YR +L    ++  +    +F+
Sbjct: 152 LEKCLKNIHRID-----LKTKIQKYKQSVQGAG----TSYRNVLQAAIQKSLKDPSNNFR 202

Query: 122 FL 123
            +
Sbjct: 203 MI 204


>gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo
           sapiens]
          Length = 432

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 76/262 (29%), Positives = 118/262 (45%), Gaps = 37/262 (14%)

Query: 242 HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-Q 300
           ++ +KAR  +  L  I+ R G   D  AL      L FE     D T +   E L  + +
Sbjct: 175 YDLSKARAAL-LLAVIQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFRE 233

Query: 301 LMD--HSNMDCFICCILSHGD-KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI 357
            +D     + C +  +++HG  +G + G DGQE     L  + +  +C  L G+PK+F +
Sbjct: 234 QLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQPEALMQELS--RCQVLQGRPKIFLL 291

Query: 358 QACQGDNYQKGI--------------PVETDSEE---QPYLEMDLSSPQTRYIP----DE 396
           QAC+G N   G+              P    S     Q Y E   SS   R  P    D+
Sbjct: 292 QACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQGSS--CRGTPPGSSDQ 349

Query: 397 ADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD-- 454
           AD L   +     V+YR+  +G+ +IQ+L + LR     G D+L +LTEVN  V  ++  
Sbjct: 350 ADILTVYSAAEGYVAYRDD-KGSDFIQTLVEVLRAN--PGRDLLELLTEVNRRVCEQEVL 406

Query: 455 --DKKNMGKQMPQPTFTLRKKL 474
             D   + K   +   +LR++L
Sbjct: 407 GPDCDELRKACLEIRSSLRRRL 428


>gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo
           sapiens]
          Length = 432

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 76/262 (29%), Positives = 118/262 (45%), Gaps = 37/262 (14%)

Query: 242 HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-Q 300
           ++ +KAR  +  L  I+ R G   D  AL      L FE     D T +   E L  + +
Sbjct: 175 YDLSKARAAL-LLAVIQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFRE 233

Query: 301 LMD--HSNMDCFICCILSHGD-KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI 357
            +D     + C +  +++HG  +G + G DGQE     L  + +  +C  L G+PK+F +
Sbjct: 234 QLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQPEALMQELS--RCQVLQGRPKIFLL 291

Query: 358 QACQGDNYQKGI--------------PVETDSEE---QPYLEMDLSSPQTRYIP----DE 396
           QAC+G N   G+              P    S     Q Y E   SS   R  P    D+
Sbjct: 292 QACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQGSS--CRGTPPGSSDQ 349

Query: 397 ADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD-- 454
           AD L   +     V+YR+  +G+ +IQ+L + LR     G D+L +LTEVN  V  ++  
Sbjct: 350 ADILTVYSAAEGYVAYRDD-KGSDFIQTLVEVLRAN--PGRDLLELLTEVNRRVCEQEVL 406

Query: 455 --DKKNMGKQMPQPTFTLRKKL 474
             D   + K   +   +LR++L
Sbjct: 407 GPDCDELRKACLEIRSSLRRRL 428


>gi|15718702 caspase 7 isoform beta [Homo sapiens]
          Length = 253

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 36/97 (37%), Positives = 54/97 (55%), Gaps = 7/97 (7%)

Query: 226 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 285
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 60  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112

Query: 286 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI 322
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +
Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENM 149


>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
          Length = 311

 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 31/277 (11%)

Query: 197 SNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHS 256
           S  E    + ++ ++ R    +S  +  +    S+ R   LII N  F           S
Sbjct: 34  SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTR-LALIICNEEF----------DS 82

Query: 257 IRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSNMDCFICCIL 315
           I  R G  +D   +T   + L + +    + T   +   L+ +    +H   D      +
Sbjct: 83  IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFM 142

Query: 316 SHGDK-GIIYGTDGQEAP-IYELTSQFTGLK---CPSLAGKPKVFFIQACQGDNYQKGIP 370
           SHG + GI      ++ P I +L + F  L    CPSL  KPKV  IQAC+GD+     P
Sbjct: 143 SHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS-----P 197

Query: 371 VETDSEEQPYLEMDLSSPQTRYIPDEA--------DFLLGMATVNNCVSYRNPAEGTWYI 422
                ++   +  +LS P T    D+A        DF+   ++  + VS+R+P  G+ +I
Sbjct: 198 GVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFI 257

Query: 423 QSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNM 459
             L + ++E      D+  I  +V +     D +  M
Sbjct: 258 GRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPDGRAQM 293


>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
          Length = 404

 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 31/277 (11%)

Query: 197 SNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHS 256
           S  E    + ++ ++ R    +S  +  +    S+ R   LII N  F           S
Sbjct: 127 SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTR-LALIICNEEF----------DS 175

Query: 257 IRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSNMDCFICCIL 315
           I  R G  +D   +T   + L + +    + T   +   L+ +    +H   D      +
Sbjct: 176 IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFM 235

Query: 316 SHGDK-GIIYGTDGQEAP-IYELTSQFTGLK---CPSLAGKPKVFFIQACQGDNYQKGIP 370
           SHG + GI      ++ P I +L + F  L    CPSL  KPKV  IQAC+GD+     P
Sbjct: 236 SHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS-----P 290

Query: 371 VETDSEEQPYLEMDLSSPQTRYIPDEA--------DFLLGMATVNNCVSYRNPAEGTWYI 422
                ++   +  +LS P T    D+A        DF+   ++  + VS+R+P  G+ +I
Sbjct: 291 GVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFI 350

Query: 423 QSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNM 459
             L + ++E      D+  I  +V +     D +  M
Sbjct: 351 GRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPDGRAQM 386


>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
          Length = 383

 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 31/277 (11%)

Query: 197 SNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHS 256
           S  E    + ++ ++ R    +S  +  +    S+ R   LII N  F           S
Sbjct: 106 SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTR-LALIICNEEF----------DS 154

Query: 257 IRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSNMDCFICCIL 315
           I  R G  +D   +T   + L + +    + T   +   L+ +    +H   D      +
Sbjct: 155 IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFM 214

Query: 316 SHGDK-GIIYGTDGQEAP-IYELTSQFTGLK---CPSLAGKPKVFFIQACQGDNYQKGIP 370
           SHG + GI      ++ P I +L + F  L    CPSL  KPKV  IQAC+GD+     P
Sbjct: 215 SHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS-----P 269

Query: 371 VETDSEEQPYLEMDLSSPQTRYIPDEA--------DFLLGMATVNNCVSYRNPAEGTWYI 422
                ++   +  +LS P T    D+A        DF+   ++  + VS+R+P  G+ +I
Sbjct: 270 GVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFI 329

Query: 423 QSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNM 459
             L + ++E      D+  I  +V +     D +  M
Sbjct: 330 GRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPDGRAQM 365


>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
          Length = 447

 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 79/326 (24%), Positives = 139/326 (42%), Gaps = 46/326 (14%)

Query: 120 FKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILK--RVCAQI-NKSLLKIIN 176
           F +L + ++   K ++     D  IE +K +IL    +D L+  RV  Q+  ++LL +  
Sbjct: 97  FNYLAKHDVLTLKEEEKKKYYDTKIE-DKALIL----VDSLRKNRVAHQMFTQTLLNM-- 149

Query: 177 DYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSE--SQTLDKVYQMKSKP-- 232
           D +  S +    +E  P E +    +  +      PRE+      +  D++Y +K +   
Sbjct: 150 DQKITSVKPLLQIEAGPPESAESTNILKLC-----PREEFLRLCKKNHDEIYPIKKREDR 204

Query: 233 RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQI 292
           R   LII N  F    + +P       RNG H D   +    + L + +    + T   +
Sbjct: 205 RRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDM 254

Query: 293 YEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYELTSQ-FTGLKCP 346
             +L+ +    +H + D     ++SHG    I GT  ++      +Y+   Q F    C 
Sbjct: 255 ESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCL 314

Query: 347 SLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSSPQTRYIPDEADF 399
           SL  KPKV  +QAC+G+     + +  P       S+    LE D        I +E DF
Sbjct: 315 SLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD----SVCKIHEEKDF 370

Query: 400 LLGMATVNNCVSYRNPAEGTWYIQSL 425
           +   ++  + VS+R+   G+ +I  L
Sbjct: 371 IAFCSSTPHNVSWRDRTRGSIFITEL 396


>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
          Length = 376

 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 79/326 (24%), Positives = 139/326 (42%), Gaps = 46/326 (14%)

Query: 120 FKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILK--RVCAQI-NKSLLKIIN 176
           F +L + ++   K ++     D  IE +K +IL    +D L+  RV  Q+  ++LL +  
Sbjct: 26  FNYLAKHDVLTLKEEEKKKYYDTKIE-DKALIL----VDSLRKNRVAHQMFTQTLLNM-- 78

Query: 177 DYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSE--SQTLDKVYQMKSKP-- 232
           D +  S +    +E  P E +    +  +      PRE+      +  D++Y +K +   
Sbjct: 79  DQKITSVKPLLQIEAGPPESAESTNILKLC-----PREEFLRLCKKNHDEIYPIKKREDR 133

Query: 233 RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQI 292
           R   LII N  F    + +P       RNG H D   +    + L + +    + T   +
Sbjct: 134 RRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDM 183

Query: 293 YEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYELTSQ-FTGLKCP 346
             +L+ +    +H + D     ++SHG    I GT  ++      +Y+   Q F    C 
Sbjct: 184 ESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCL 243

Query: 347 SLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSSPQTRYIPDEADF 399
           SL  KPKV  +QAC+G+     + +  P       S+    LE D        I +E DF
Sbjct: 244 SLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD----SVCKIHEEKDF 299

Query: 400 LLGMATVNNCVSYRNPAEGTWYIQSL 425
           +   ++  + VS+R+   G+ +I  L
Sbjct: 300 IAFCSSTPHNVSWRDRTRGSIFITEL 325


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,332,098
Number of Sequences: 37866
Number of extensions: 861617
Number of successful extensions: 2497
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 2340
Number of HSP's gapped (non-prelim): 129
length of query: 479
length of database: 18,247,518
effective HSP length: 106
effective length of query: 373
effective length of database: 14,233,722
effective search space: 5309178306
effective search space used: 5309178306
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.