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Search of human proteins with 15718704
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
(496 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15718704 caspase 8 isoform A precursor [Homo sapiens] 1005 0.0
gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 918 0.0
gi|15718708 caspase 8 isoform C precursor [Homo sapiens] 918 0.0
gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 908 0.0
gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 908 0.0
gi|15718712 caspase 8 isoform E [Homo sapiens] 336 3e-92
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 280 2e-75
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 270 3e-72
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 217 2e-56
gi|15718698 caspase 7 isoform delta [Homo sapiens] 161 1e-39
gi|15718700 caspase 7 isoform alpha [Homo sapiens] 161 1e-39
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 161 1e-39
gi|14790115 caspase 3 preproprotein [Homo sapiens] 159 7e-39
gi|14790119 caspase 3 preproprotein [Homo sapiens] 159 7e-39
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 139 5e-33
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens] 129 5e-30
gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1 [... 119 6e-27
gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1 [... 119 6e-27
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 119 8e-27
gi|14916485 caspase 6 isoform beta [Homo sapiens] 102 1e-21
gi|6912286 caspase 14 precursor [Homo sapiens] 94 4e-19
gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo sap... 71 3e-12
gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo sap... 71 3e-12
gi|15718702 caspase 7 isoform beta [Homo sapiens] 70 6e-12
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 65 2e-10
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 65 2e-10
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 65 2e-10
gi|187608585 CASP8 and FADD-like apoptosis regulator isoform 2 [... 57 3e-08
gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 56 7e-08
gi|209870073 caspase 5 isoform c [Homo sapiens] 56 7e-08
>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
Length = 496
Score = 1005 bits (2599), Expect = 0.0
Identities = 496/496 (100%), Positives = 496/496 (100%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120
Query: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180
SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK
Sbjct: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180
Query: 181 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD 240
RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD
Sbjct: 181 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD 240
Query: 241 KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP 300
KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP
Sbjct: 241 KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP 300
Query: 301 HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 360
HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL
Sbjct: 301 HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 360
Query: 361 KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM 420
KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM
Sbjct: 361 KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM 420
Query: 421 ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM 480
ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM
Sbjct: 421 ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM 480
Query: 481 PQPTFTLRKKLVFPSD 496
PQPTFTLRKKLVFPSD
Sbjct: 481 PQPTFTLRKKLVFPSD 496
>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 918 bits (2373), Expect = 0.0
Identities = 464/496 (93%), Positives = 464/496 (93%), Gaps = 32/496 (6%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY------------------- 101
Query: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180
RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK
Sbjct: 102 -------------RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 148
Query: 181 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD 240
RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD
Sbjct: 149 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD 208
Query: 241 KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP 300
KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP
Sbjct: 209 KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP 268
Query: 301 HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 360
HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL
Sbjct: 269 HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 328
Query: 361 KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM 420
KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM
Sbjct: 329 KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM 388
Query: 421 ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM 480
ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM
Sbjct: 389 ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM 448
Query: 481 PQPTFTLRKKLVFPSD 496
PQPTFTLRKKLVFPSD
Sbjct: 449 PQPTFTLRKKLVFPSD 464
>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 918 bits (2373), Expect = 0.0
Identities = 464/496 (93%), Positives = 464/496 (93%), Gaps = 32/496 (6%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY------------------- 101
Query: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180
RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK
Sbjct: 102 -------------RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 148
Query: 181 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD 240
RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD
Sbjct: 149 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD 208
Query: 241 KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP 300
KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP
Sbjct: 209 KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP 268
Query: 301 HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 360
HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL
Sbjct: 269 HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 328
Query: 361 KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM 420
KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM
Sbjct: 329 KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM 388
Query: 421 ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM 480
ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM
Sbjct: 389 ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM 448
Query: 481 PQPTFTLRKKLVFPSD 496
PQPTFTLRKKLVFPSD
Sbjct: 449 PQPTFTLRKKLVFPSD 464
>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
Length = 538
Score = 908 bits (2347), Expect = 0.0
Identities = 464/511 (90%), Positives = 464/511 (90%), Gaps = 47/511 (9%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 60 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 119
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY
Sbjct: 120 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY------------------- 160
Query: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180
RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK
Sbjct: 161 -------------RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 207
Query: 181 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSK---------------GEELCGVMTI 225
RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSK GEELCGVMTI
Sbjct: 208 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTI 267
Query: 226 SDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAG 285
SDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAG
Sbjct: 268 SDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAG 327
Query: 286 ALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDG 345
ALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDG
Sbjct: 328 ALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDG 387
Query: 346 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSP 405
QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSP
Sbjct: 388 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSP 447
Query: 406 QTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNY 465
QTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNY
Sbjct: 448 QTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNY 507
Query: 466 EVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 496
EVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 508 EVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 538
>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
Length = 479
Score = 908 bits (2347), Expect = 0.0
Identities = 464/511 (90%), Positives = 464/511 (90%), Gaps = 47/511 (9%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY------------------- 101
Query: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180
RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK
Sbjct: 102 -------------RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 148
Query: 181 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSK---------------GEELCGVMTI 225
RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSK GEELCGVMTI
Sbjct: 149 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTI 208
Query: 226 SDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAG 285
SDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAG
Sbjct: 209 SDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAG 268
Query: 286 ALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDG 345
ALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDG
Sbjct: 269 ALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDG 328
Query: 346 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSP 405
QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSP
Sbjct: 329 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSP 388
Query: 406 QTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNY 465
QTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNY
Sbjct: 389 QTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNY 448
Query: 466 EVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 496
EVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 449 EVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 479
>gi|15718712 caspase 8 isoform E [Homo sapiens]
Length = 235
Score = 336 bits (862), Expect = 3e-92
Identities = 183/215 (85%), Positives = 183/215 (85%), Gaps = 32/215 (14%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY------------------- 101
Query: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180
RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK
Sbjct: 102 -------------RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 148
Query: 181 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSK 215
RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSK
Sbjct: 149 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSK 183
>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
Length = 479
Score = 280 bits (716), Expect = 2e-75
Identities = 186/511 (36%), Positives = 265/511 (51%), Gaps = 74/511 (14%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120
FL ELL+ I + LL +LN KEE+ER L P R ++S
Sbjct: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVS--------------------- 113
Query: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180
L R +LY++SE + L+ FLL++ + K +M L +EK
Sbjct: 114 -----------LFRNLLYELSEGIDSENLKDMIFLLKDSLPK----TEMTSLSFLAFLEK 158
Query: 181 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMT------ISDSPREQDS 234
+ + E L L+ +C + LL+ I Y K E+ ++T E++
Sbjct: 159 QGKIDEDNLTCLEDLCKTVVPKLLRNIEKY----KREKAIQIVTPPVDKEAESYQGEEEL 214
Query: 235 ESQTLDK----------VYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDA 284
SQT K VY+M RG C+I+NNH+F S++DR GTH DA
Sbjct: 215 VSQTDVKTFLEALPRAAVYRMNRNHRGLCVIVNNHSFT----------SLKDRQGTHKDA 264
Query: 285 GALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMD-HSNMDCFICCILSHGDKGIIYGT 343
L+ F+ L F + H++ T ++ +L+ + H++ DCF+ CIL+HG G +Y +
Sbjct: 265 EILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSS 324
Query: 344 DGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLS 403
D PI E+ S FT L+CP LA KPK+FFIQACQG+ Q + +E D+ L
Sbjct: 325 DEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQ 384
Query: 404 SPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEV 463
IP EADFLLG+ATV VS+R+ EG+WYIQSLC L++ PR +DIL+ILT V
Sbjct: 385 DS----IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAV 440
Query: 464 NYEVSNKDDKKNMGKQMPQPTFTLRKKLVFP 494
N +VS + DK+ KQMPQP FTLRKKLVFP
Sbjct: 441 NDDVSRRVDKQGTKKQMPQPAFTLRKKLVFP 471
>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
Length = 522
Score = 270 bits (689), Expect = 3e-72
Identities = 189/550 (34%), Positives = 270/550 (49%), Gaps = 109/550 (19%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120
FL ELL+ I + LL +LN KEE+ER L P R ++S
Sbjct: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVS--------------------- 113
Query: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180
L R +LY++SE + L+ FLL++ + K +M L +EK
Sbjct: 114 -----------LFRNLLYELSEGIDSENLKDMIFLLKDSLPKT----EMTSLSFLAFLEK 158
Query: 181 RVILGEGKLDILKRVCAQINKSLLKIINDY-----------------EEFSKGEELCG-- 221
+ + E L L+ +C + LL+ I Y E + EEL
Sbjct: 159 QGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQT 218
Query: 222 -VMTISDS-PRE--------------------------QDSESQTLDK--------VYQM 245
V T ++ P+E Q + + TL+ VY+M
Sbjct: 219 DVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRM 278
Query: 246 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 305
RG C+I+NNH+F S++DR GTH DA L+ F+ L F + H++ T
Sbjct: 279 NRNHRGLCVIVNNHSFT----------SLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVT 328
Query: 306 VEQIYEILKIYQLMD-HSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPS 364
++ +L+ + H++ DCF+ CIL+HG G +Y +D PI E+ S FT L+CP
Sbjct: 329 KVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPR 388
Query: 365 LAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVN 424
LA KPK+FFIQACQG+ Q + +E D+ L IP EADFLLG+ATV
Sbjct: 389 LAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDS----IPAEADFLLGLATVP 444
Query: 425 NCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPT 484
VS+R+ EG+WYIQSLC L++ PR +DIL+ILT VN +VS + DK+ KQMPQP
Sbjct: 445 GYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPA 504
Query: 485 FTLRKKLVFP 494
FTLRKKLVFP
Sbjct: 505 FTLRKKLVFP 514
>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
Length = 521
Score = 217 bits (552), Expect = 2e-56
Identities = 161/508 (31%), Positives = 237/508 (46%), Gaps = 109/508 (21%)
Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77
Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120
FL ELL+ I + LL +LN KEE+ER L P R ++S
Sbjct: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVS--------------------- 113
Query: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180
L R +LY++SE + L+ FLL++ + K +M L +EK
Sbjct: 114 -----------LFRNLLYELSEGIDSENLKDMIFLLKDSLPKT----EMTSLSFLAFLEK 158
Query: 181 RVILGEGKLDILKRVCAQINKSLLKIINDY-----------------EEFSKGEELCG-- 221
+ + E L L+ +C + LL+ I Y E + EEL
Sbjct: 159 QGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQT 218
Query: 222 -VMTISDS-PRE--------------------------QDSESQTLDK--------VYQM 245
V T ++ P+E Q + + TL+ VY+M
Sbjct: 219 DVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRM 278
Query: 246 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 305
RG C+I+NNH+F S++DR GTH DA L+ F+ L F + H++ T
Sbjct: 279 NRNHRGLCVIVNNHSFT----------SLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVT 328
Query: 306 VEQIYEILKIYQLMD-HSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPS 364
++ +L+ + H++ DCF+ CIL+HG G +Y +D PI E+ S FT L+CP
Sbjct: 329 KVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPR 388
Query: 365 LAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVN 424
LA KPK+FFIQACQG+ Q + +E D+ L IP EADFLLG+ATV
Sbjct: 389 LAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDS----IPAEADFLLGLATVP 444
Query: 425 NCVSYRNPAEGTWYIQSLCQSLRERCPR 452
VS+R+ EG+WYIQSLC L++ PR
Sbjct: 445 GYVSFRHVEEGSWYIQSLCNHLKKLVPR 472
>gi|15718698 caspase 7 isoform delta [Homo sapiens]
Length = 336
Score = 161 bits (407), Expect = 1e-39
Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)
Query: 243 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 302
Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++
Sbjct: 93 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 145
Query: 303 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 362
DC+ ++ ++LK DH+N CF C +LSHG++ +IYG DG PI +LT+ F G +C
Sbjct: 146 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 204
Query: 363 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 422
+L KPK+FFIQAC+G GI ++ P + D ++P+ + IP EADFL +T
Sbjct: 205 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 258
Query: 423 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 476
V S+R+P G+W++Q+LC L E + +I+ ILT VN +E + D +
Sbjct: 259 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 317
Query: 477 GKQMPQPTFTLRKKLVF 493
KQ+P L K+L F
Sbjct: 318 KKQIPCVVSMLTKELYF 334
>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
Length = 303
Score = 161 bits (407), Expect = 1e-39
Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)
Query: 243 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 302
Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++
Sbjct: 60 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112
Query: 303 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 362
DC+ ++ ++LK DH+N CF C +LSHG++ +IYG DG PI +LT+ F G +C
Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171
Query: 363 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 422
+L KPK+FFIQAC+G GI ++ P + D ++P+ + IP EADFL +T
Sbjct: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225
Query: 423 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 476
V S+R+P G+W++Q+LC L E + +I+ ILT VN +E + D +
Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284
Query: 477 GKQMPQPTFTLRKKLVF 493
KQ+P L K+L F
Sbjct: 285 KKQIPCVVSMLTKELYF 301
>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
Length = 303
Score = 161 bits (407), Expect = 1e-39
Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)
Query: 243 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 302
Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++
Sbjct: 60 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112
Query: 303 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 362
DC+ ++ ++LK DH+N CF C +LSHG++ +IYG DG PI +LT+ F G +C
Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171
Query: 363 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 422
+L KPK+FFIQAC+G GI ++ P + D ++P+ + IP EADFL +T
Sbjct: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225
Query: 423 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 476
V S+R+P G+W++Q+LC L E + +I+ ILT VN +E + D +
Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284
Query: 477 GKQMPQPTFTLRKKLVF 493
KQ+P L K+L F
Sbjct: 285 KKQIPCVVSMLTKELYF 301
>gi|14790115 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 159 bits (401), Expect = 7e-39
Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)
Query: 238 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 297
+LD Y+M G C+IINN NF K+ + R+GT +DA L TF L +E
Sbjct: 32 SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84
Query: 298 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 357
++ +D T E+I E+++ DHS F+C +LSHG++GII+GT+G + ++T+ F
Sbjct: 85 VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143
Query: 358 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 417
G +C SL GKPK+F IQAC+G GI ETDS ++ D++ + IP EADFL
Sbjct: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194
Query: 418 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 471
+T S+RN +G+W+IQSLC L++ + + + ILT VN +V+ + D
Sbjct: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253
Query: 472 DKKNMGKQMPQPTFTLRKKLVF 493
+ KQ+P L K+L F
Sbjct: 254 ATFHAKKQIPCIVSMLTKELYF 275
>gi|14790119 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 159 bits (401), Expect = 7e-39
Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)
Query: 238 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 297
+LD Y+M G C+IINN NF K+ + R+GT +DA L TF L +E
Sbjct: 32 SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84
Query: 298 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 357
++ +D T E+I E+++ DHS F+C +LSHG++GII+GT+G + ++T+ F
Sbjct: 85 VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143
Query: 358 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 417
G +C SL GKPK+F IQAC+G GI ETDS ++ D++ + IP EADFL
Sbjct: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194
Query: 418 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 471
+T S+RN +G+W+IQSLC L++ + + + ILT VN +V+ + D
Sbjct: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253
Query: 472 DKKNMGKQMPQPTFTLRKKLVF 493
+ KQ+P L K+L F
Sbjct: 254 ATFHAKKQIPCIVSMLTKELYF 275
>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
Length = 416
Score = 139 bits (351), Expect = 5e-33
Identities = 91/276 (32%), Positives = 134/276 (48%), Gaps = 34/276 (12%)
Query: 240 DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIK 299
D Y + +P G+CLIINN NF + +R R G+++D L F LHF ++
Sbjct: 150 DLAYILSMEPCGHCLIINNVNFCRES-------GLRTRTGSNIDCEKLRRRFSSLHFMVE 202
Query: 300 PHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDK-------GIIYGTDGQEAPIYE 352
D T +++ L DH +DC + ILSHG + G +YGTDG + +
Sbjct: 203 VKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEK 262
Query: 353 LTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ------------PYLEM 400
+ + F G CPSL GKPK+FFIQAC G+ G V + S E P+ E
Sbjct: 263 IVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEG 322
Query: 401 DLSSPQTRYI---PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDIL 457
+ Q I P +D + +T VS+R+P G+WY+++L + E+ +D+
Sbjct: 323 LRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL-DDIFEQWAHSEDLQ 381
Query: 458 TILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVF 493
++L V+N K + KQMP LRKKL F
Sbjct: 382 SLL----LRVANAVSVKGIYKQMPGCFNFLRKKLFF 413
>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
Length = 293
Score = 129 bits (325), Expect = 5e-30
Identities = 94/267 (35%), Positives = 135/267 (50%), Gaps = 31/267 (11%)
Query: 243 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 302
Y+M + RG LI N+ F ++ +R GT D LT F +L FE+K +
Sbjct: 37 YKMDHRRRGIALIFNHERFFWHL-------TLPERRGTCADRDNLTRRFSDLGFEVKCFN 89
Query: 303 DCTVEQIYEILKIYQL--MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 360
D E++ +LKI+++ + H++ DCF+C LSHG+ IY D + I LT F G
Sbjct: 90 DLKAEEL--LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGD 146
Query: 361 KCPSLAGKPKVFFIQACQGDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPD 412
KC SL GKPK+F IQAC+G+ Q +PV +T+ + E+D +S T +P
Sbjct: 147 KCHSLVGKPKIFIIQACRGN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPA 202
Query: 413 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN--- 469
ADFL+ + S+R G+WYIQ LC+ L + + +LT VN +VS
Sbjct: 203 GADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRV 261
Query: 470 ---KDDKKNMGKQMPQPTFTLRKKLVF 493
KD KQ+P L KKL F
Sbjct: 262 DFCKDPSAIGKKQVPCFASMLTKKLHF 288
>gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1
[Homo sapiens]
Length = 480
Score = 119 bits (298), Expect = 6e-27
Identities = 130/537 (24%), Positives = 227/537 (42%), Gaps = 117/537 (21%)
Query: 7 LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
++ + E LD+++ L FL D ++D L + L+E+ L +L+ ELL
Sbjct: 6 IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59
Query: 67 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWR 126
+R+ R DLL L ++ +E L
Sbjct: 60 YRVRRFDLLKRILKMDRKAVETHLL----------------------------------- 84
Query: 127 RVDHLL--IRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVIL 184
R HL+ RV++ +I E++ +S++ S FL+++ + + K+ + + LD+ +E+EK ++
Sbjct: 85 RNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLV 144
Query: 185 GEGKLDILKRVCAQINKSLLKI-INDYEEFSKG--------------------------- 216
+LD+L++ I++ LK I Y++ +G
Sbjct: 145 APDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPSNNFRLH 204
Query: 217 ---------EELCGVMTISDSPREQDSES---QTL-DKVYQMKSKPRGYCLIINNHNFAK 263
+E G Q+SE+ Q++ ++ Y+MKSKP G CLII+
Sbjct: 205 NGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIPEERYKMKSKPLGICLIIDCIG--- 261
Query: 264 AREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLM-DHS 322
N T L L TF L +E++ ++ I +IL + M +H
Sbjct: 262 --------------NETEL----LRDTFTSLGYEVQKFLHLSMHGISQILGQFACMPEHR 303
Query: 323 NMDCFICCILSHGDKGIIYGTDGQEA--PIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQ 378
+ D F+C ++S G +YG D + P++ + F G CP LAGKPK+FFIQ
Sbjct: 304 DYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVS 363
Query: 379 GDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWY 438
+ +E D +E + EADF + T + + ++ + + Y
Sbjct: 364 EGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLY 423
Query: 439 IQSLCQSLRERCPRGDDILTILTEVN---YEVSNKDDKKNMGKQMPQPTFTLRKKLV 492
+Q L Q LR+ R +L + E+N Y+ +++ K K TLRKKL+
Sbjct: 424 LQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNSRVSAKE--KYYVWLQHTLRKKLI 476
Score = 44.3 bits (103), Expect = 3e-04
Identities = 35/136 (25%), Positives = 58/136 (42%), Gaps = 18/136 (13%)
Query: 2 DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF 61
D+ + +IGE LD D++SL FL DY+ + K K L L L++ ++ L
Sbjct: 92 DYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDL 151
Query: 62 LKELLFRINRLDLL--------------ITYLNTRKEEMERELQTPGRAQISAYRFHFCR 107
L++ L I+R+DL +Y N + +++ L+ P + +R H R
Sbjct: 152 LEKCLKNIHRIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPS----NNFRLHNGR 207
Query: 108 MSWAEANSQCQTQSVP 123
Q Q P
Sbjct: 208 SKEQRLKEQLGAQQEP 223
>gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1
[Homo sapiens]
Length = 480
Score = 119 bits (298), Expect = 6e-27
Identities = 130/537 (24%), Positives = 227/537 (42%), Gaps = 117/537 (21%)
Query: 7 LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
++ + E LD+++ L FL D ++D L + L+E+ L +L+ ELL
Sbjct: 6 IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59
Query: 67 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWR 126
+R+ R DLL L ++ +E L
Sbjct: 60 YRVRRFDLLKRILKMDRKAVETHLL----------------------------------- 84
Query: 127 RVDHLL--IRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVIL 184
R HL+ RV++ +I E++ +S++ S FL+++ + + K+ + + LD+ +E+EK ++
Sbjct: 85 RNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLV 144
Query: 185 GEGKLDILKRVCAQINKSLLKI-INDYEEFSKG--------------------------- 216
+LD+L++ I++ LK I Y++ +G
Sbjct: 145 APDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPSNNFRLH 204
Query: 217 ---------EELCGVMTISDSPREQDSES---QTL-DKVYQMKSKPRGYCLIINNHNFAK 263
+E G Q+SE+ Q++ ++ Y+MKSKP G CLII+
Sbjct: 205 NGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIPEERYKMKSKPLGICLIIDCIG--- 261
Query: 264 AREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLM-DHS 322
N T L L TF L +E++ ++ I +IL + M +H
Sbjct: 262 --------------NETEL----LRDTFTSLGYEVQKFLHLSMHGISQILGQFACMPEHR 303
Query: 323 NMDCFICCILSHGDKGIIYGTDGQEA--PIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQ 378
+ D F+C ++S G +YG D + P++ + F G CP LAGKPK+FFIQ
Sbjct: 304 DYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVS 363
Query: 379 GDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWY 438
+ +E D +E + EADF + T + + ++ + + Y
Sbjct: 364 EGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLY 423
Query: 439 IQSLCQSLRERCPRGDDILTILTEVN---YEVSNKDDKKNMGKQMPQPTFTLRKKLV 492
+Q L Q LR+ R +L + E+N Y+ +++ K K TLRKKL+
Sbjct: 424 LQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNSRVSAKE--KYYVWLQHTLRKKLI 476
Score = 44.3 bits (103), Expect = 3e-04
Identities = 35/136 (25%), Positives = 58/136 (42%), Gaps = 18/136 (13%)
Query: 2 DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF 61
D+ + +IGE LD D++SL FL DY+ + K K L L L++ ++ L
Sbjct: 92 DYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDL 151
Query: 62 LKELLFRINRLDLL--------------ITYLNTRKEEMERELQTPGRAQISAYRFHFCR 107
L++ L I+R+DL +Y N + +++ L+ P + +R H R
Sbjct: 152 LEKCLKNIHRIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPS----NNFRLHNGR 207
Query: 108 MSWAEANSQCQTQSVP 123
Q Q P
Sbjct: 208 SKEQRLKEQLGAQQEP 223
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 119 bits (297), Expect = 8e-27
Identities = 74/237 (31%), Positives = 122/237 (51%), Gaps = 18/237 (7%)
Query: 243 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 302
Y+++S+PRG L+++N +F +E + R+G +D L T F+ L +++
Sbjct: 192 YRLQSRPRGLALVLSNVHFTGEKE-------LEFRSGGDVDHSTLVTLFKLLGYDVHVLC 244
Query: 303 DCTVEQIYEILKIY-QLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLK 361
D T +++ E L+ + QL H D I +LSHG +G IYG DG+ + E+ F
Sbjct: 245 DQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNAN 304
Query: 362 CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSS------PQTRYIPDEAD 415
CPSL KPK+FFIQAC+GD +G+ + + S P+ R +P +D
Sbjct: 305 CPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMR-LPTRSD 363
Query: 416 FLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER-CPRGDDILTILTEVNYEVSNKD 471
+ G A + + RN G+WYI++L Q ER C + +L +VN + +++
Sbjct: 364 MICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM--HVADMLVKVNALIKDRE 418
>gi|14916485 caspase 6 isoform beta [Homo sapiens]
Length = 204
Score = 102 bits (253), Expect = 1e-21
Identities = 70/189 (37%), Positives = 96/189 (50%), Gaps = 20/189 (10%)
Query: 319 MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQ 378
+ H++ DCF+C LSHG+ IY D + I LT F G KC SL GKPK+F IQAC+
Sbjct: 17 VSHADADCFVCVFLSHGEGNHIYAYDAK-IEIQTLTGLFKGDKCHSLVGKPKIFIIQACR 75
Query: 379 GDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYR 430
G+ Q +PV +T+ + E+D +S T +P ADFL+ + S+R
Sbjct: 76 GN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPAGADFLMCYSVAEGYYSHR 131
Query: 431 NPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN------KDDKKNMGKQMPQPT 484
G+WYIQ LC+ L + + +LT VN +VS KD KQ+P
Sbjct: 132 ETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFA 190
Query: 485 FTLRKKLVF 493
L KKL F
Sbjct: 191 SMLTKKLHF 199
>gi|6912286 caspase 14 precursor [Homo sapiens]
Length = 242
Score = 93.6 bits (231), Expect = 4e-19
Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 14/220 (6%)
Query: 277 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMD---CFICCILS 333
R G+ D AL F +L FE D T EQ E L+ +Q S D C +++
Sbjct: 29 REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88
Query: 334 HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSE 393
HG +G + G DG+ + L C +L KPKV+ IQAC+G+ G V D
Sbjct: 89 HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDE- 147
Query: 394 EQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRG 453
+ + SPQT IP D L +TV ++YR+ +G+ +IQ+L + R
Sbjct: 148 ---IVMVIKDSPQT--IPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK---RK 199
Query: 454 DDILTILTEVNYEVSNKD--DKKNMGKQMPQPTFTLRKKL 491
IL +LTEV ++ + + K P+ TLRK+L
Sbjct: 200 GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRL 239
>gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo
sapiens]
Length = 432
Score = 70.9 bits (172), Expect = 3e-12
Identities = 76/262 (29%), Positives = 118/262 (45%), Gaps = 37/262 (14%)
Query: 259 HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-Q 317
++ +KAR + L I+ R G D AL L FE D T + E L + +
Sbjct: 175 YDLSKARAAL-LLAVIQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFRE 233
Query: 318 LMD--HSNMDCFICCILSHGD-KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI 374
+D + C + +++HG +G + G DGQE L + + +C L G+PK+F +
Sbjct: 234 QLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQPEALMQELS--RCQVLQGRPKIFLL 291
Query: 375 QACQGDNYQKGI--------------PVETDSEE---QPYLEMDLSSPQTRYIP----DE 413
QAC+G N G+ P S Q Y E SS R P D+
Sbjct: 292 QACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQGSS--CRGTPPGSSDQ 349
Query: 414 ADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD-- 471
AD L + V+YR+ +G+ +IQ+L + LR G D+L +LTEVN V ++
Sbjct: 350 ADILTVYSAAEGYVAYRDD-KGSDFIQTLVEVLRAN--PGRDLLELLTEVNRRVCEQEVL 406
Query: 472 --DKKNMGKQMPQPTFTLRKKL 491
D + K + +LR++L
Sbjct: 407 GPDCDELRKACLEIRSSLRRRL 428
>gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo
sapiens]
Length = 432
Score = 70.9 bits (172), Expect = 3e-12
Identities = 76/262 (29%), Positives = 118/262 (45%), Gaps = 37/262 (14%)
Query: 259 HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-Q 317
++ +KAR + L I+ R G D AL L FE D T + E L + +
Sbjct: 175 YDLSKARAAL-LLAVIQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFRE 233
Query: 318 LMD--HSNMDCFICCILSHGD-KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI 374
+D + C + +++HG +G + G DGQE L + + +C L G+PK+F +
Sbjct: 234 QLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQPEALMQELS--RCQVLQGRPKIFLL 291
Query: 375 QACQGDNYQKGI--------------PVETDSEE---QPYLEMDLSSPQTRYIP----DE 413
QAC+G N G+ P S Q Y E SS R P D+
Sbjct: 292 QACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQGSS--CRGTPPGSSDQ 349
Query: 414 ADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD-- 471
AD L + V+YR+ +G+ +IQ+L + LR G D+L +LTEVN V ++
Sbjct: 350 ADILTVYSAAEGYVAYRDD-KGSDFIQTLVEVLRAN--PGRDLLELLTEVNRRVCEQEVL 406
Query: 472 --DKKNMGKQMPQPTFTLRKKL 491
D + K + +LR++L
Sbjct: 407 GPDCDELRKACLEIRSSLRRRL 428
>gi|15718702 caspase 7 isoform beta [Homo sapiens]
Length = 253
Score = 69.7 bits (169), Expect = 6e-12
Identities = 36/97 (37%), Positives = 54/97 (55%), Gaps = 7/97 (7%)
Query: 243 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 302
Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++
Sbjct: 60 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112
Query: 303 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI 339
DC+ ++ ++LK DH+N CF C +LSHG++ +
Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENM 149
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 64.7 bits (156), Expect = 2e-10
Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%)
Query: 246 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 305
KS LII N F SI R G +D +T + L + + + T
Sbjct: 65 KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 114
Query: 306 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 361
+ L+ + +H D +SHG + GI ++ P I +L + F L
Sbjct: 115 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 174
Query: 362 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 414
CPSL KPKV IQAC+GD+ P ++ + +LS P T D+A
Sbjct: 175 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 229
Query: 415 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 471
DF+ ++ + VS+R+P G+ +I L + ++E D+ I +V + D
Sbjct: 230 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 288
Query: 472 DKKNM 476
+ M
Sbjct: 289 GRAQM 293
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 64.7 bits (156), Expect = 2e-10
Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%)
Query: 246 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 305
KS LII N F SI R G +D +T + L + + + T
Sbjct: 158 KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 207
Query: 306 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 361
+ L+ + +H D +SHG + GI ++ P I +L + F L
Sbjct: 208 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 267
Query: 362 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 414
CPSL KPKV IQAC+GD+ P ++ + +LS P T D+A
Sbjct: 268 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 322
Query: 415 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 471
DF+ ++ + VS+R+P G+ +I L + ++E D+ I +V + D
Sbjct: 323 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 381
Query: 472 DKKNM 476
+ M
Sbjct: 382 GRAQM 386
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 64.7 bits (156), Expect = 2e-10
Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%)
Query: 246 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 305
KS LII N F SI R G +D +T + L + + + T
Sbjct: 137 KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 186
Query: 306 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 361
+ L+ + +H D +SHG + GI ++ P I +L + F L
Sbjct: 187 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 246
Query: 362 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 414
CPSL KPKV IQAC+GD+ P ++ + +LS P T D+A
Sbjct: 247 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 301
Query: 415 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 471
DF+ ++ + VS+R+P G+ +I L + ++E D+ I +V + D
Sbjct: 302 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 360
Query: 472 DKKNM 476
+ M
Sbjct: 361 GRAQM 365
>gi|187608585 CASP8 and FADD-like apoptosis regulator isoform 2
[Homo sapiens]
Length = 221
Score = 57.4 bits (137), Expect = 3e-08
Identities = 50/213 (23%), Positives = 99/213 (46%), Gaps = 44/213 (20%)
Query: 7 LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
++ + E LD+++ L FL D ++D L + L+E+ L +L+ ELL
Sbjct: 6 IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59
Query: 67 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWR 126
+R+ R DLL L ++ +E L
Sbjct: 60 YRVRRFDLLKRILKMDRKAVETHLL----------------------------------- 84
Query: 127 RVDHLL--IRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVIL 184
R HL+ RV++ +I E++ +S++ S FL+++ + + K+ + + LD+ +E+EK ++
Sbjct: 85 RNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLV 144
Query: 185 GEGKLDILKRVCAQINKSLLKI-INDYEEFSKG 216
+LD+L++ I++ LK I Y++ +G
Sbjct: 145 APDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQG 177
Score = 43.9 bits (102), Expect = 3e-04
Identities = 28/93 (30%), Positives = 49/93 (52%), Gaps = 5/93 (5%)
Query: 2 DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF 61
D+ + +IGE LD D++SL FL DY+ + K K L L L++ ++ L
Sbjct: 92 DYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDL 151
Query: 62 LKELLFRINRLDLLITYLNTRKEEMERELQTPG 94
L++ L I+R+D L T+ ++ ++ +Q G
Sbjct: 152 LEKCLKNIHRID-----LKTKIQKYKQSVQGAG 179
>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
Length = 447
Score = 56.2 bits (134), Expect = 7e-08
Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%)
Query: 240 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 297
D++Y +K + R LII N F + +P RNG H D + + L +
Sbjct: 193 DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 242
Query: 298 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 352
+ + T + +L+ + +H + D ++SHG I GT ++ +Y+
Sbjct: 243 VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 302
Query: 353 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 404
Q F C SL KPKV +QAC+G+ + + P S+ LE D
Sbjct: 303 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 359
Query: 405 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 442
I +E DF+ ++ + VS+R+ G+ +I L
Sbjct: 360 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 396
>gi|209870073 caspase 5 isoform c [Homo sapiens]
Length = 292
Score = 56.2 bits (134), Expect = 7e-08
Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%)
Query: 240 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 297
D++Y +K + R LII N F + +P RNG H D + + L +
Sbjct: 38 DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 87
Query: 298 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 352
+ + T + +L+ + +H + D ++SHG I GT ++ +Y+
Sbjct: 88 VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 147
Query: 353 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 404
Q F C SL KPKV +QAC+G+ + + P S+ LE D
Sbjct: 148 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 204
Query: 405 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 442
I +E DF+ ++ + VS+R+ G+ +I L
Sbjct: 205 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 241
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,979,711
Number of Sequences: 37866
Number of extensions: 878844
Number of successful extensions: 2292
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 2148
Number of HSP's gapped (non-prelim): 87
length of query: 496
length of database: 18,247,518
effective HSP length: 106
effective length of query: 390
effective length of database: 14,233,722
effective search space: 5551151580
effective search space used: 5551151580
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.