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Search of human proteins with 11056054
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11056054 tribbles homolog 2 [Homo sapiens]
(343 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11056054 tribbles homolog 2 [Homo sapiens] 698 0.0
gi|13399328 G-protein-coupled receptor induced protein [Homo sap... 382 e-106
gi|31542265 tribbles 3 [Homo sapiens] 288 5e-78
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 123 3e-28
gi|26051204 calcium/calmodulin-dependent protein kinase II beta ... 119 5e-27
gi|26051210 calcium/calmodulin-dependent protein kinase II beta ... 119 5e-27
gi|26051214 calcium/calmodulin-dependent protein kinase II beta ... 119 5e-27
gi|26051206 calcium/calmodulin-dependent protein kinase II beta ... 119 5e-27
gi|26051216 calcium/calmodulin-dependent protein kinase II beta ... 119 5e-27
gi|26051218 calcium/calmodulin-dependent protein kinase II beta ... 119 5e-27
gi|26051212 calcium/calmodulin-dependent protein kinase II beta ... 119 5e-27
gi|26051208 calcium/calmodulin-dependent protein kinase II beta ... 119 5e-27
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 118 7e-27
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 117 1e-26
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 117 1e-26
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 116 3e-26
gi|31543198 serine/threonine kinase 40 [Homo sapiens] 115 4e-26
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 115 6e-26
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 115 6e-26
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 115 6e-26
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 115 6e-26
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 115 6e-26
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 115 6e-26
gi|121114283 polo-like kinase 4 [Homo sapiens] 114 2e-25
gi|156105707 SNF related kinase [Homo sapiens] 112 6e-25
gi|156105705 SNF related kinase [Homo sapiens] 112 6e-25
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 112 6e-25
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 111 8e-25
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 111 1e-24
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 111 1e-24
>gi|11056054 tribbles homolog 2 [Homo sapiens]
Length = 343
Score = 698 bits (1801), Expect = 0.0
Identities = 343/343 (100%), Positives = 343/343 (100%)
Query: 1 MNIHRSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFSPNLGSPSPPETPNLSHCVSC 60
MNIHRSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFSPNLGSPSPPETPNLSHCVSC
Sbjct: 1 MNIHRSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFSPNLGSPSPPETPNLSHCVSC 60
Query: 61 IGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNINQITEII 120
IGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNINQITEII
Sbjct: 61 IGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNINQITEII 120
Query: 121 LGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRK 180
LGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRK
Sbjct: 121 LGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRK 180
Query: 181 FIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSL 240
FIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSL
Sbjct: 181 FIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSL 240
Query: 241 GVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQ 300
GVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQ
Sbjct: 241 GVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQ 300
Query: 301 EILDHPWFSTDFSVSNSAYGAKEVSDQLVPDVNMEENLDPFFN 343
EILDHPWFSTDFSVSNSAYGAKEVSDQLVPDVNMEENLDPFFN
Sbjct: 301 EILDHPWFSTDFSVSNSAYGAKEVSDQLVPDVNMEENLDPFFN 343
>gi|13399328 G-protein-coupled receptor induced protein [Homo
sapiens]
Length = 372
Score = 382 bits (982), Expect = e-106
Identities = 198/322 (61%), Positives = 239/322 (74%), Gaps = 16/322 (4%)
Query: 33 AEPSQSFSPNLGSPSPPETPNLSHCV----------SCIGKYLLLEPLEGDHVFRAVHLH 82
+ P SP GSP P+ P + S I YLLL E +HV RA+ +H
Sbjct: 54 SSPPDYLSPP-GSPCSPQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIH 112
Query: 83 SGEELVCKVFDISCYQESLAPCFCLSAHSNINQITEIILGETKAYVFFERSYGDMHSFVR 142
+G EL CKVF I YQ+ + P L +HSNI I E+ILGETKAYVFFE+ +GDMHS+VR
Sbjct: 113 TGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVR 172
Query: 143 TCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYIL 202
+ K+LREEEAARLF QI SAVAHCH +VL DLKLRKF+F EERT+++LESLED +I+
Sbjct: 173 SRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIM 232
Query: 203 RGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSL 262
+G+DD+LSDKHGCPAYVSPEILNT+G+YSGKAADVWSLGVMLYT+LVGRYPFHD +PS+L
Sbjct: 233 KGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSAL 292
Query: 263 FSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSAYGAK 322
FSKIRRGQF IPE +SPKA+CLIRS+LRREPSERLT+ EIL HPWF SV Y
Sbjct: 293 FSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFE---SVLEPGYIDS 349
Query: 323 EV--SDQLVPDVNMEENLDPFF 342
E+ SDQ+VP+ + ++ FF
Sbjct: 350 EIGTSDQIVPEYQEDSDISSFF 371
>gi|31542265 tribbles 3 [Homo sapiens]
Length = 358
Score = 288 bits (737), Expect = 5e-78
Identities = 154/317 (48%), Positives = 201/317 (63%), Gaps = 10/317 (3%)
Query: 5 RSTPITIARYGRSRNKTQDFEE-LSSIRSAE------PSQSFSPNLGSPSPPETPNLSHC 57
R+TP+ SR K + ++ L + R + P P L SPP P+ +
Sbjct: 2 RATPLAAPAGSLSRKKRLELDDNLDTERPVQKRARSGPQPRLPPCLLPLSPPTAPDRATA 61
Query: 58 V---SCIGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNIN 114
V S +G Y+LLEP EG ++A+H +G E CKV+ + L P L H ++
Sbjct: 62 VATASRLGPYVLLEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVA 121
Query: 115 QITEIILGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLR 174
+ TE++ G Y FF R++GDMHS VR+ ++ E EAA LF Q+A+A+AHCH GLVLR
Sbjct: 122 RPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLR 181
Query: 175 DLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKA 234
DLKL +F+F D ER ++ LE+LED+ +L G DDSL DKH CPAYV PEIL++ SYSGKA
Sbjct: 182 DLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKA 241
Query: 235 ADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPS 294
ADVWSLGV L+TML G YPF D EP LF KIRRG + +P LS A+CL+R +LRREP+
Sbjct: 242 ADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPA 301
Query: 295 ERLTSQEILDHPWFSTD 311
ERLT+ IL HPW D
Sbjct: 302 ERLTATGILLHPWLRQD 318
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 123 bits (308), Expect = 3e-28
Identities = 77/246 (31%), Positives = 130/246 (52%), Gaps = 15/246 (6%)
Query: 78 AVHLHSGEELVCKVFDISCYQESLA------PCFCLSAHSNINQITEIILGETKAYVFFE 131
A H+ +GE + K+ D + L H +I Q+ ++ ET +F
Sbjct: 28 ACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVL--ETANKIFMV 85
Query: 132 RSY---GDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEER 188
Y G++ ++ + +L EEE +F QI SAVA+ H G RDLK +F +E
Sbjct: 86 LEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLF--DEY 143
Query: 189 TRVKLESLEDAYILRGDDD-SLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTM 247
++KL +G+ D L G AY +PE++ SY G ADVWS+G++LY +
Sbjct: 144 HKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGK-SYLGSEADVWSMGILLYVL 202
Query: 248 LVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPW 307
+ G PF D +L+ KI RG++++P+ LSP + L++ +L+ +P +R++ + +L+HPW
Sbjct: 203 MCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPW 262
Query: 308 FSTDFS 313
D++
Sbjct: 263 IMQDYN 268
>gi|26051204 calcium/calmodulin-dependent protein kinase II beta
isoform 1 [Homo sapiens]
Length = 666
Score = 119 bits (297), Expect = 5e-27
Identities = 82/263 (31%), Positives = 130/263 (49%), Gaps = 15/263 (5%)
Query: 75 VFRAVHLHSGEELVCKVFDISCYQ-------ESLAPCFCLSAHSNINQITEIILGETKAY 127
V R V L +G E K+ + E A L HSNI ++ + I E Y
Sbjct: 28 VRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHY 87
Query: 128 VFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDE 186
+ F+ + G++ + + E +A+ QI AV HCH G+V RDLK + +
Sbjct: 88 LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 147
Query: 187 -ERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLY 245
+ VKL A ++GD + G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 148 CKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILY 205
Query: 246 TMLVGRYPFHDIEPSSLFSKIRRGQFNIP----ETLSPKAKCLIRSILRREPSERLTSQE 301
+LVG PF D + L+ +I+ G ++ P +T++P+AK LI +L P++R+T+ E
Sbjct: 206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHE 265
Query: 302 ILDHPWFSTDFSVSNSAYGAKEV 324
L HPW +V++ + + V
Sbjct: 266 ALKHPWVCQRSTVASMMHRQETV 288
>gi|26051210 calcium/calmodulin-dependent protein kinase II beta
isoform 4 [Homo sapiens]
Length = 517
Score = 119 bits (297), Expect = 5e-27
Identities = 82/263 (31%), Positives = 130/263 (49%), Gaps = 15/263 (5%)
Query: 75 VFRAVHLHSGEELVCKVFDISCYQ-------ESLAPCFCLSAHSNINQITEIILGETKAY 127
V R V L +G E K+ + E A L HSNI ++ + I E Y
Sbjct: 28 VRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHY 87
Query: 128 VFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDE 186
+ F+ + G++ + + E +A+ QI AV HCH G+V RDLK + +
Sbjct: 88 LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 147
Query: 187 -ERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLY 245
+ VKL A ++GD + G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 148 CKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILY 205
Query: 246 TMLVGRYPFHDIEPSSLFSKIRRGQFNIP----ETLSPKAKCLIRSILRREPSERLTSQE 301
+LVG PF D + L+ +I+ G ++ P +T++P+AK LI +L P++R+T+ E
Sbjct: 206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHE 265
Query: 302 ILDHPWFSTDFSVSNSAYGAKEV 324
L HPW +V++ + + V
Sbjct: 266 ALKHPWVCQRSTVASMMHRQETV 288
>gi|26051214 calcium/calmodulin-dependent protein kinase II beta
isoform 6 [Homo sapiens]
Length = 492
Score = 119 bits (297), Expect = 5e-27
Identities = 82/263 (31%), Positives = 130/263 (49%), Gaps = 15/263 (5%)
Query: 75 VFRAVHLHSGEELVCKVFDISCYQ-------ESLAPCFCLSAHSNINQITEIILGETKAY 127
V R V L +G E K+ + E A L HSNI ++ + I E Y
Sbjct: 28 VRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHY 87
Query: 128 VFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDE 186
+ F+ + G++ + + E +A+ QI AV HCH G+V RDLK + +
Sbjct: 88 LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 147
Query: 187 -ERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLY 245
+ VKL A ++GD + G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 148 CKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILY 205
Query: 246 TMLVGRYPFHDIEPSSLFSKIRRGQFNIP----ETLSPKAKCLIRSILRREPSERLTSQE 301
+LVG PF D + L+ +I+ G ++ P +T++P+AK LI +L P++R+T+ E
Sbjct: 206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHE 265
Query: 302 ILDHPWFSTDFSVSNSAYGAKEV 324
L HPW +V++ + + V
Sbjct: 266 ALKHPWVCQRSTVASMMHRQETV 288
>gi|26051206 calcium/calmodulin-dependent protein kinase II beta
isoform 2 [Homo sapiens]
Length = 542
Score = 119 bits (297), Expect = 5e-27
Identities = 82/263 (31%), Positives = 130/263 (49%), Gaps = 15/263 (5%)
Query: 75 VFRAVHLHSGEELVCKVFDISCYQ-------ESLAPCFCLSAHSNINQITEIILGETKAY 127
V R V L +G E K+ + E A L HSNI ++ + I E Y
Sbjct: 28 VRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHY 87
Query: 128 VFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDE 186
+ F+ + G++ + + E +A+ QI AV HCH G+V RDLK + +
Sbjct: 88 LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 147
Query: 187 -ERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLY 245
+ VKL A ++GD + G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 148 CKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILY 205
Query: 246 TMLVGRYPFHDIEPSSLFSKIRRGQFNIP----ETLSPKAKCLIRSILRREPSERLTSQE 301
+LVG PF D + L+ +I+ G ++ P +T++P+AK LI +L P++R+T+ E
Sbjct: 206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHE 265
Query: 302 ILDHPWFSTDFSVSNSAYGAKEV 324
L HPW +V++ + + V
Sbjct: 266 ALKHPWVCQRSTVASMMHRQETV 288
>gi|26051216 calcium/calmodulin-dependent protein kinase II beta
isoform 7 [Homo sapiens]
Length = 479
Score = 119 bits (297), Expect = 5e-27
Identities = 82/263 (31%), Positives = 130/263 (49%), Gaps = 15/263 (5%)
Query: 75 VFRAVHLHSGEELVCKVFDISCYQ-------ESLAPCFCLSAHSNINQITEIILGETKAY 127
V R V L +G E K+ + E A L HSNI ++ + I E Y
Sbjct: 28 VRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHY 87
Query: 128 VFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDE 186
+ F+ + G++ + + E +A+ QI AV HCH G+V RDLK + +
Sbjct: 88 LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 147
Query: 187 -ERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLY 245
+ VKL A ++GD + G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 148 CKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILY 205
Query: 246 TMLVGRYPFHDIEPSSLFSKIRRGQFNIP----ETLSPKAKCLIRSILRREPSERLTSQE 301
+LVG PF D + L+ +I+ G ++ P +T++P+AK LI +L P++R+T+ E
Sbjct: 206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHE 265
Query: 302 ILDHPWFSTDFSVSNSAYGAKEV 324
L HPW +V++ + + V
Sbjct: 266 ALKHPWVCQRSTVASMMHRQETV 288
>gi|26051218 calcium/calmodulin-dependent protein kinase II beta
isoform 8 [Homo sapiens]
Length = 449
Score = 119 bits (297), Expect = 5e-27
Identities = 82/263 (31%), Positives = 130/263 (49%), Gaps = 15/263 (5%)
Query: 75 VFRAVHLHSGEELVCKVFDISCYQ-------ESLAPCFCLSAHSNINQITEIILGETKAY 127
V R V L +G E K+ + E A L HSNI ++ + I E Y
Sbjct: 28 VRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHY 87
Query: 128 VFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDE 186
+ F+ + G++ + + E +A+ QI AV HCH G+V RDLK + +
Sbjct: 88 LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 147
Query: 187 -ERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLY 245
+ VKL A ++GD + G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 148 CKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILY 205
Query: 246 TMLVGRYPFHDIEPSSLFSKIRRGQFNIP----ETLSPKAKCLIRSILRREPSERLTSQE 301
+LVG PF D + L+ +I+ G ++ P +T++P+AK LI +L P++R+T+ E
Sbjct: 206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHE 265
Query: 302 ILDHPWFSTDFSVSNSAYGAKEV 324
L HPW +V++ + + V
Sbjct: 266 ALKHPWVCQRSTVASMMHRQETV 288
>gi|26051212 calcium/calmodulin-dependent protein kinase II beta
isoform 5 [Homo sapiens]
Length = 503
Score = 119 bits (297), Expect = 5e-27
Identities = 82/263 (31%), Positives = 130/263 (49%), Gaps = 15/263 (5%)
Query: 75 VFRAVHLHSGEELVCKVFDISCYQ-------ESLAPCFCLSAHSNINQITEIILGETKAY 127
V R V L +G E K+ + E A L HSNI ++ + I E Y
Sbjct: 28 VRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHY 87
Query: 128 VFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDE 186
+ F+ + G++ + + E +A+ QI AV HCH G+V RDLK + +
Sbjct: 88 LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 147
Query: 187 -ERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLY 245
+ VKL A ++GD + G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 148 CKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILY 205
Query: 246 TMLVGRYPFHDIEPSSLFSKIRRGQFNIP----ETLSPKAKCLIRSILRREPSERLTSQE 301
+LVG PF D + L+ +I+ G ++ P +T++P+AK LI +L P++R+T+ E
Sbjct: 206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHE 265
Query: 302 ILDHPWFSTDFSVSNSAYGAKEV 324
L HPW +V++ + + V
Sbjct: 266 ALKHPWVCQRSTVASMMHRQETV 288
>gi|26051208 calcium/calmodulin-dependent protein kinase II beta
isoform 3 [Homo sapiens]
Length = 518
Score = 119 bits (297), Expect = 5e-27
Identities = 82/263 (31%), Positives = 130/263 (49%), Gaps = 15/263 (5%)
Query: 75 VFRAVHLHSGEELVCKVFDISCYQ-------ESLAPCFCLSAHSNINQITEIILGETKAY 127
V R V L +G E K+ + E A L HSNI ++ + I E Y
Sbjct: 28 VRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHY 87
Query: 128 VFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDE 186
+ F+ + G++ + + E +A+ QI AV HCH G+V RDLK + +
Sbjct: 88 LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 147
Query: 187 -ERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLY 245
+ VKL A ++GD + G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 148 CKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILY 205
Query: 246 TMLVGRYPFHDIEPSSLFSKIRRGQFNIP----ETLSPKAKCLIRSILRREPSERLTSQE 301
+LVG PF D + L+ +I+ G ++ P +T++P+AK LI +L P++R+T+ E
Sbjct: 206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHE 265
Query: 302 ILDHPWFSTDFSVSNSAYGAKEV 324
L HPW +V++ + + V
Sbjct: 266 ALKHPWVCQRSTVASMMHRQETV 288
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 118 bits (296), Expect = 7e-27
Identities = 74/231 (32%), Positives = 118/231 (51%), Gaps = 9/231 (3%)
Query: 107 LSAHSNINQITEIILGETKAYVFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVAH 165
L H +I ++ ++I T ++ E S G++ ++ ++ E EA RLF QI SAV +
Sbjct: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129
Query: 166 CHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILN 225
CH +V RDLK + ++ L + + D + L G P Y +PE+++
Sbjct: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPEVIS 186
Query: 226 TSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLI 285
Y+G D+WS GV+LY +L G PF D +LF KIR G F IPE L+ L+
Sbjct: 187 -GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLL 245
Query: 286 RSILRREPSERLTSQEILDHPWFSTDFS----VSNSAYGAKEVSDQLVPDV 332
+L+ +P +R T ++I +H WF D + +Y A + D+ V +V
Sbjct: 246 MHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEV 296
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 117 bits (293), Expect = 1e-26
Identities = 87/285 (30%), Positives = 137/285 (48%), Gaps = 20/285 (7%)
Query: 57 CVSCIGKYLLLEPLEGDHVF----RAVHLHSGEELVCKVFDISCYQ-------ESLAPCF 105
C +Y L E L G F R V + +G+E K+ + E A
Sbjct: 6 CTRFTEEYQLFEEL-GKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARIC 64
Query: 106 CLSAHSNINQITEIILGETKAYVFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVA 164
L H NI ++ + I E Y+ F+ + G++ + + E +A+ QI AV
Sbjct: 65 RLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVL 124
Query: 165 HCHDGGLVLRDLKLRKFIFKDEER-TRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEI 223
HCH G+V RDLK + + + VKL A + G+ + G P Y+SPE+
Sbjct: 125 HCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV 184
Query: 224 LNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIP----ETLSP 279
L GK D+W+ GV+LY +LVG PF D + L+ +I+ G ++ P +T++P
Sbjct: 185 LRKDPY--GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTP 242
Query: 280 KAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSAYGAKEV 324
+AK LI +L PS+R+T+ E L HPW S +V++ + + V
Sbjct: 243 EAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETV 287
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 117 bits (293), Expect = 1e-26
Identities = 87/285 (30%), Positives = 137/285 (48%), Gaps = 20/285 (7%)
Query: 57 CVSCIGKYLLLEPLEGDHVF----RAVHLHSGEELVCKVFDISCYQ-------ESLAPCF 105
C +Y L E L G F R V + +G+E K+ + E A
Sbjct: 6 CTRFTEEYQLFEEL-GKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARIC 64
Query: 106 CLSAHSNINQITEIILGETKAYVFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVA 164
L H NI ++ + I E Y+ F+ + G++ + + E +A+ QI AV
Sbjct: 65 RLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVL 124
Query: 165 HCHDGGLVLRDLKLRKFIFKDEER-TRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEI 223
HCH G+V RDLK + + + VKL A + G+ + G P Y+SPE+
Sbjct: 125 HCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV 184
Query: 224 LNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIP----ETLSP 279
L GK D+W+ GV+LY +LVG PF D + L+ +I+ G ++ P +T++P
Sbjct: 185 LRKDPY--GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTP 242
Query: 280 KAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSAYGAKEV 324
+AK LI +L PS+R+T+ E L HPW S +V++ + + V
Sbjct: 243 EAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETV 287
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 116 bits (291), Expect = 3e-26
Identities = 78/279 (27%), Positives = 135/279 (48%), Gaps = 18/279 (6%)
Query: 44 GSPS---PPETPNLSHCVSCIGKYLLLEPL---EGDHVFRAVHLHSGEELVCKVFDISCY 97
GSP+ P P+ +G Y L + L + V VH +G+++ K+ +
Sbjct: 11 GSPAYHLPHPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKL 70
Query: 98 QESLA-------PCFCLSAHSNINQITEIILGETKAYVFFER-SYGDMHSFVRTCKKLRE 149
ES+ L H ++ ++ ++ + Y+ E S G++ ++ +L
Sbjct: 71 SESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTP 130
Query: 150 EEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSL 209
+EA + F QI SA+ CH + RDLK + +E+ +++ A + GD L
Sbjct: 131 KEARKFFRQIVSALDFCHSYSICHRDLKPENLLL--DEKNNIRIADFGMASLQVGDS-LL 187
Query: 210 SDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRG 269
G P Y PE++ Y G+ AD+WS GV+L+ +LVG PF D L K++RG
Sbjct: 188 ETSCGSPHYACPEVIKGE-KYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRG 246
Query: 270 QFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWF 308
F++P + P + L+R ++ EP +RL+ ++I HPW+
Sbjct: 247 VFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWY 285
>gi|31543198 serine/threonine kinase 40 [Homo sapiens]
Length = 435
Score = 115 bits (289), Expect = 4e-26
Identities = 66/201 (32%), Positives = 108/201 (53%), Gaps = 19/201 (9%)
Query: 106 CLSAHSNINQITEIILGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAH 165
CL AH ++ ++I ++ +V K+L E E +FY + V
Sbjct: 143 CLCAHDFSDKTADLI---------------NLQHYVIKEKRLSERETVVIFYDVVRVVEA 187
Query: 166 CHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILN 225
H +V RDLKL + ++ R+ + + L + D L D+ G PAY+SP++L+
Sbjct: 188 LHQKNIVHRDLKLGNMVL-NKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLS 246
Query: 226 TSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPE--TLSPKAKC 283
Y GK +D+W+LGV+L+TML G++PF+D P LF KI+ ++ IPE +S C
Sbjct: 247 -GRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVC 305
Query: 284 LIRSILRREPSERLTSQEILD 304
LIR +L +P +RL + ++L+
Sbjct: 306 LIRKLLVLDPQQRLAAADVLE 326
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 115 bits (288), Expect = 6e-26
Identities = 84/285 (29%), Positives = 137/285 (48%), Gaps = 20/285 (7%)
Query: 57 CVSCIGKYLLLEPLEGDHVF----RAVHLHSGEELVCKVFDISCYQ-------ESLAPCF 105
C +Y L E L G F R + + +G+E K+ + E A
Sbjct: 7 CTRFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC 65
Query: 106 CLSAHSNINQITEIILGETKAYVFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVA 164
L H NI ++ + I E Y+ F+ + G++ + + E +A+ QI +V
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125
Query: 165 HCHDGGLVLRDLKLRKFIFKDEER-TRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEI 223
HCH G+V RDLK + + + VKL A ++GD + G P Y+SPE+
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185
Query: 224 LNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIP----ETLSP 279
L GK D+W+ GV+LY +LVG PF D + L+ +I+ G ++ P +T++P
Sbjct: 186 LRKDPY--GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTP 243
Query: 280 KAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSAYGAKEV 324
+AK LI +L P++R+T+ E L HPW +V++ + + V
Sbjct: 244 EAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETV 288
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 115 bits (288), Expect = 6e-26
Identities = 84/285 (29%), Positives = 137/285 (48%), Gaps = 20/285 (7%)
Query: 57 CVSCIGKYLLLEPLEGDHVF----RAVHLHSGEELVCKVFDISCYQ-------ESLAPCF 105
C +Y L E L G F R + + +G+E K+ + E A
Sbjct: 7 CTRFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC 65
Query: 106 CLSAHSNINQITEIILGETKAYVFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVA 164
L H NI ++ + I E Y+ F+ + G++ + + E +A+ QI +V
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125
Query: 165 HCHDGGLVLRDLKLRKFIFKDEER-TRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEI 223
HCH G+V RDLK + + + VKL A ++GD + G P Y+SPE+
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185
Query: 224 LNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIP----ETLSP 279
L GK D+W+ GV+LY +LVG PF D + L+ +I+ G ++ P +T++P
Sbjct: 186 LRKDPY--GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTP 243
Query: 280 KAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSAYGAKEV 324
+AK LI +L P++R+T+ E L HPW +V++ + + V
Sbjct: 244 EAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETV 288
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 115 bits (288), Expect = 6e-26
Identities = 84/285 (29%), Positives = 137/285 (48%), Gaps = 20/285 (7%)
Query: 57 CVSCIGKYLLLEPLEGDHVF----RAVHLHSGEELVCKVFDISCYQ-------ESLAPCF 105
C +Y L E L G F R + + +G+E K+ + E A
Sbjct: 7 CTRFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC 65
Query: 106 CLSAHSNINQITEIILGETKAYVFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVA 164
L H NI ++ + I E Y+ F+ + G++ + + E +A+ QI +V
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125
Query: 165 HCHDGGLVLRDLKLRKFIFKDEER-TRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEI 223
HCH G+V RDLK + + + VKL A ++GD + G P Y+SPE+
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185
Query: 224 LNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIP----ETLSP 279
L GK D+W+ GV+LY +LVG PF D + L+ +I+ G ++ P +T++P
Sbjct: 186 LRKDPY--GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTP 243
Query: 280 KAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSAYGAKEV 324
+AK LI +L P++R+T+ E L HPW +V++ + + V
Sbjct: 244 EAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETV 288
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 115 bits (288), Expect = 6e-26
Identities = 84/285 (29%), Positives = 137/285 (48%), Gaps = 20/285 (7%)
Query: 57 CVSCIGKYLLLEPLEGDHVF----RAVHLHSGEELVCKVFDISCYQ-------ESLAPCF 105
C +Y L E L G F R + + +G+E K+ + E A
Sbjct: 7 CTRFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC 65
Query: 106 CLSAHSNINQITEIILGETKAYVFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVA 164
L H NI ++ + I E Y+ F+ + G++ + + E +A+ QI +V
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125
Query: 165 HCHDGGLVLRDLKLRKFIFKDEER-TRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEI 223
HCH G+V RDLK + + + VKL A ++GD + G P Y+SPE+
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185
Query: 224 LNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIP----ETLSP 279
L GK D+W+ GV+LY +LVG PF D + L+ +I+ G ++ P +T++P
Sbjct: 186 LRKDPY--GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTP 243
Query: 280 KAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSAYGAKEV 324
+AK LI +L P++R+T+ E L HPW +V++ + + V
Sbjct: 244 EAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETV 288
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 115 bits (288), Expect = 6e-26
Identities = 84/285 (29%), Positives = 137/285 (48%), Gaps = 20/285 (7%)
Query: 57 CVSCIGKYLLLEPLEGDHVF----RAVHLHSGEELVCKVFDISCYQ-------ESLAPCF 105
C +Y L E L G F R + + +G+E K+ + E A
Sbjct: 7 CTRFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC 65
Query: 106 CLSAHSNINQITEIILGETKAYVFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVA 164
L H NI ++ + I E Y+ F+ + G++ + + E +A+ QI +V
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125
Query: 165 HCHDGGLVLRDLKLRKFIFKDEER-TRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEI 223
HCH G+V RDLK + + + VKL A ++GD + G P Y+SPE+
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185
Query: 224 LNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIP----ETLSP 279
L GK D+W+ GV+LY +LVG PF D + L+ +I+ G ++ P +T++P
Sbjct: 186 LRKDPY--GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTP 243
Query: 280 KAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSAYGAKEV 324
+AK LI +L P++R+T+ E L HPW +V++ + + V
Sbjct: 244 EAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETV 288
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 115 bits (288), Expect = 6e-26
Identities = 84/285 (29%), Positives = 137/285 (48%), Gaps = 20/285 (7%)
Query: 57 CVSCIGKYLLLEPLEGDHVF----RAVHLHSGEELVCKVFDISCYQ-------ESLAPCF 105
C +Y L E L G F R + + +G+E K+ + E A
Sbjct: 7 CTRFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC 65
Query: 106 CLSAHSNINQITEIILGETKAYVFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVA 164
L H NI ++ + I E Y+ F+ + G++ + + E +A+ QI +V
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125
Query: 165 HCHDGGLVLRDLKLRKFIFKDEER-TRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEI 223
HCH G+V RDLK + + + VKL A ++GD + G P Y+SPE+
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185
Query: 224 LNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIP----ETLSP 279
L GK D+W+ GV+LY +LVG PF D + L+ +I+ G ++ P +T++P
Sbjct: 186 LRKDPY--GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTP 243
Query: 280 KAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSAYGAKEV 324
+AK LI +L P++R+T+ E L HPW +V++ + + V
Sbjct: 244 EAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETV 288
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 114 bits (284), Expect = 2e-25
Identities = 76/261 (29%), Positives = 122/261 (46%), Gaps = 14/261 (5%)
Query: 75 VFRAVHLHSGEELVCKVFDISCYQ--------ESLAPCFCLSAHSNINQITEIILGETKA 126
V+RA +H+G E+ K+ D ++ C H +I ++
Sbjct: 26 VYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYV 85
Query: 127 YVFFERSY-GDMHSFVRT-CKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFK 184
Y+ E + G+M+ +++ K E EA +QI + + + H G++ RDL L +
Sbjct: 86 YLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT 145
Query: 185 DEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVML 244
+K+ A L+ + G P Y+SPEI S G +DVWSLG M
Sbjct: 146 --RNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH--GLESDVWSLGCMF 201
Query: 245 YTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILD 304
YT+L+GR PF + +K+ + +P LS +AK LI +LRR P++RL+ +LD
Sbjct: 202 YTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLD 261
Query: 305 HPWFSTDFSVSNSAYGAKEVS 325
HP+ S + S + G E S
Sbjct: 262 HPFMSRNSSTKSKDLGTVEDS 282
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 112 bits (279), Expect = 6e-25
Identities = 78/241 (32%), Positives = 125/241 (51%), Gaps = 16/241 (6%)
Query: 78 AVHLHSGEELVCKVFDIS---------CYQESLAPCFCLSAHSNINQITEIILGETKAYV 128
A H+ +GE++ KV D + +QE C L H NI ++ E+I +TK Y+
Sbjct: 33 ARHVFTGEKVAVKVIDKTKLDTLATGHLFQE--VRCMKLVQHPNIVRLYEVIDTQTKLYL 90
Query: 129 FFERSYG-DMHSFVRTCKK-LREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDE 186
E G DM ++ ++ L E+ A + F QI A+++CH +V RDLK +F E
Sbjct: 91 ILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFF-E 149
Query: 187 ERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYT 246
++ VKL + + L+ G AY +PEIL Y A D+WSLGV+L+
Sbjct: 150 KQGLVKLTDFGFSNKFQ-PGKKLTTSCGSLAYSAPEIL-LGDEYDAPAVDIWSLGVILFM 207
Query: 247 MLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHP 306
++ G+ PF + S + I ++ +P +S + K LI +L+R+P R + +EI +HP
Sbjct: 208 LVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHP 267
Query: 307 W 307
W
Sbjct: 268 W 268
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 112 bits (279), Expect = 6e-25
Identities = 78/241 (32%), Positives = 125/241 (51%), Gaps = 16/241 (6%)
Query: 78 AVHLHSGEELVCKVFDIS---------CYQESLAPCFCLSAHSNINQITEIILGETKAYV 128
A H+ +GE++ KV D + +QE C L H NI ++ E+I +TK Y+
Sbjct: 33 ARHVFTGEKVAVKVIDKTKLDTLATGHLFQE--VRCMKLVQHPNIVRLYEVIDTQTKLYL 90
Query: 129 FFERSYG-DMHSFVRTCKK-LREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDE 186
E G DM ++ ++ L E+ A + F QI A+++CH +V RDLK +F E
Sbjct: 91 ILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFF-E 149
Query: 187 ERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYT 246
++ VKL + + L+ G AY +PEIL Y A D+WSLGV+L+
Sbjct: 150 KQGLVKLTDFGFSNKFQ-PGKKLTTSCGSLAYSAPEIL-LGDEYDAPAVDIWSLGVILFM 207
Query: 247 MLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHP 306
++ G+ PF + S + I ++ +P +S + K LI +L+R+P R + +EI +HP
Sbjct: 208 LVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHP 267
Query: 307 W 307
W
Sbjct: 268 W 268
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 112 bits (279), Expect = 6e-25
Identities = 69/207 (33%), Positives = 103/207 (49%), Gaps = 6/207 (2%)
Query: 110 HSNINQITEIILGETKAYVFFE-RSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHD 168
H +I I E+ + K + E S G+++ ++ ++L E E F QI SAV +CH
Sbjct: 112 HPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHK 171
Query: 169 GGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSG 228
G+V RDLKL + D ++ L + Y D L G P Y SPEI+N
Sbjct: 172 NGVVHRDLKLENILLDDNCNIKIADFGLSNLY---QKDKFLQTFCGSPLYASPEIVN-GR 227
Query: 229 SYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSI 288
Y G D W+LGV+LYT++ G PF + +L +I G++ P T A+ LIR +
Sbjct: 228 PYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSDARGLIRWM 286
Query: 289 LRREPSERLTSQEILDHPWFSTDFSVS 315
L P R T ++I +H W + + S
Sbjct: 287 LMVNPDRRATIEDIANHWWVNWGYKSS 313
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 111 bits (278), Expect = 8e-25
Identities = 86/322 (26%), Positives = 146/322 (45%), Gaps = 31/322 (9%)
Query: 10 TIARYGRSRNKTQDFEELSSIRSAEPSQSFSP--------NLGSPSPPETPNLSHCVSCI 61
T+ G RN + L S RS++ S+S N + P E P+ +
Sbjct: 5 TVLAPGNDRN-SDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPH-------V 56
Query: 62 GKYLLLEPLEGDHVFR---AVHLHSGEELVCKVFDI-----SCYQESLAPCFCLSA--HS 111
G Y LL + + + A H+ +G E+ K+ D S Q+ + H
Sbjct: 57 GNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHP 116
Query: 112 NINQITEIILGETKAYVFFE-RSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGG 170
NI ++ E+I E Y+ E S G++ ++ + +++E+EA F QI SAV +CH
Sbjct: 117 NIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKN 176
Query: 171 LVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSY 230
+V RDLK + E ++ + + L D+ G P Y +PE+ Y
Sbjct: 177 IVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFC---GSPPYAAPELFQGK-KY 232
Query: 231 SGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILR 290
G D+WSLGV+LYT++ G PF L ++ RG++ +P +S + ++R L
Sbjct: 233 DGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLV 292
Query: 291 REPSERLTSQEILDHPWFSTDF 312
P++R T ++I+ W + +
Sbjct: 293 LNPAKRCTLEQIMKDKWINIGY 314
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 111 bits (277), Expect = 1e-24
Identities = 68/231 (29%), Positives = 118/231 (51%), Gaps = 9/231 (3%)
Query: 107 LSAHSNINQITEIILGETKAYVFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVAH 165
L H +I ++ ++I + ++ E S G++ ++ +L E+E+ RLF QI S V +
Sbjct: 81 LFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 140
Query: 166 CHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILN 225
CH +V RDLK + ++ L + + D + L G P Y +PE+++
Sbjct: 141 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPEVIS 197
Query: 226 TSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLI 285
Y+G D+WS GV+LY +L G PF D +LF KI G F P+ L+P L+
Sbjct: 198 -GRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLL 256
Query: 286 RSILRREPSERLTSQEILDHPWFSTDFS----VSNSAYGAKEVSDQLVPDV 332
+ +L+ +P +R T ++I +H WF D + +Y + + D+ + +V
Sbjct: 257 KHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEV 307
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 111 bits (277), Expect = 1e-24
Identities = 72/233 (30%), Positives = 117/233 (50%), Gaps = 11/233 (4%)
Query: 107 LSAHSNINQITEIILG-ETKAYVFFERSYGDMHSFVRT--CKKLREEEAARLFYQIASAV 163
+S S+I + E + G E Y+ D+ V+T K+L E+E+ RLF QI S V
Sbjct: 94 ISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGV 153
Query: 164 AHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEI 223
+CH +V RDLK + ++ L + + D + L G P Y +PE+
Sbjct: 154 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPEV 210
Query: 224 LNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKC 283
++ Y+G D+WS GV+LY +L G PF D +LF KI G F P+ L+P
Sbjct: 211 IS-GRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVIS 269
Query: 284 LIRSILRREPSERLTSQEILDHPWFSTDFS----VSNSAYGAKEVSDQLVPDV 332
L++ +L+ +P +R T ++I +H WF D + +Y + + D+ + +V
Sbjct: 270 LLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEV 322
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,785,383
Number of Sequences: 37866
Number of extensions: 659003
Number of successful extensions: 3261
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 367
Number of HSP's successfully gapped in prelim test: 281
Number of HSP's that attempted gapping in prelim test: 2140
Number of HSP's gapped (non-prelim): 777
length of query: 343
length of database: 18,247,518
effective HSP length: 103
effective length of query: 240
effective length of database: 14,347,320
effective search space: 3443356800
effective search space used: 3443356800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.