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Search of human proteins with 110349792
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110349792 growth differentiation factor 1 [Homo sapiens]
(372 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110349792 growth differentiation factor 1 [Homo sapiens] 764 0.0
gi|10190670 growth differentiation factor 3 precursor [Homo sapi... 192 3e-49
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi... 120 3e-27
gi|61835232 growth differentiation factor 7 preproprotein [Homo ... 120 3e-27
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens] 119 4e-27
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap... 118 1e-26
gi|145611428 bone morphogenetic protein 8A [Homo sapiens] 117 2e-26
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa... 116 3e-26
gi|4503969 growth differentiation factor 5 preproprotein [Homo s... 110 2e-24
gi|48475062 growth differentiation factor 6 precursor [Homo sapi... 109 5e-24
gi|4504699 inhibin beta A precursor [Homo sapiens] 101 9e-22
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi... 101 9e-22
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa... 100 3e-21
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa... 100 3e-21
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa... 100 3e-21
gi|13899338 activin beta E [Homo sapiens] 98 1e-20
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa... 97 2e-20
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap... 96 4e-20
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens] 93 3e-19
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens] 93 4e-19
gi|4826740 growth differentiation factor 10 precursor [Homo sapi... 92 7e-19
gi|7705308 growth differentiation factor 2 [Homo sapiens] 92 1e-18
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens] 86 7e-17
gi|222352098 nodal precursor [Homo sapiens] 82 1e-15
gi|153792495 growth differentiation factor 15 [Homo sapiens] 80 3e-15
gi|239757187 PREDICTED: similar to growth differentiation factor... 80 3e-15
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens] 78 1e-14
gi|4885259 myostatin [Homo sapiens] 75 1e-13
gi|5031613 growth differentiation factor 11 precursor [Homo sapi... 72 1e-12
gi|4507465 transforming growth factor, beta 3 [Homo sapiens] 68 2e-11
>gi|110349792 growth differentiation factor 1 [Homo sapiens]
Length = 372
Score = 764 bits (1974), Expect = 0.0
Identities = 372/372 (100%), Positives = 372/372 (100%)
Query: 1 MPPPQQGPCGHHLLLLLALLLPSLPLTRAPVPPGPAAALLQALGLRDEPQGAPRLRPVPP 60
MPPPQQGPCGHHLLLLLALLLPSLPLTRAPVPPGPAAALLQALGLRDEPQGAPRLRPVPP
Sbjct: 1 MPPPQQGPCGHHLLLLLALLLPSLPLTRAPVPPGPAAALLQALGLRDEPQGAPRLRPVPP 60
Query: 61 VMWRLFRRRDPQETRSGSRRTSPGVTLQPCHVEELGVAGNIVRHIPDRGAPTRASEPASA 120
VMWRLFRRRDPQETRSGSRRTSPGVTLQPCHVEELGVAGNIVRHIPDRGAPTRASEPASA
Sbjct: 61 VMWRLFRRRDPQETRSGSRRTSPGVTLQPCHVEELGVAGNIVRHIPDRGAPTRASEPASA 120
Query: 121 AGHCPEWTVVFDLSAVEPAERPSRARLELRFAAAAAAAPEGGWELSVAQAGQGAGADPGP 180
AGHCPEWTVVFDLSAVEPAERPSRARLELRFAAAAAAAPEGGWELSVAQAGQGAGADPGP
Sbjct: 121 AGHCPEWTVVFDLSAVEPAERPSRARLELRFAAAAAAAPEGGWELSVAQAGQGAGADPGP 180
Query: 181 VLLRQLVPALGPPVRAELLGAAWARNASWPRSLRLALALRPRAPAACARLAEASLLLVTL 240
VLLRQLVPALGPPVRAELLGAAWARNASWPRSLRLALALRPRAPAACARLAEASLLLVTL
Sbjct: 181 VLLRQLVPALGPPVRAELLGAAWARNASWPRSLRLALALRPRAPAACARLAEASLLLVTL 240
Query: 241 DPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQC 300
DPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQC
Sbjct: 241 DPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQC 300
Query: 301 ALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQ 360
ALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQ
Sbjct: 301 ALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQ 360
Query: 361 YEDMVVDECGCR 372
YEDMVVDECGCR
Sbjct: 361 YEDMVVDECGCR 372
>gi|10190670 growth differentiation factor 3 precursor [Homo
sapiens]
Length = 364
Score = 192 bits (489), Expect = 3e-49
Identities = 133/357 (37%), Positives = 198/357 (55%), Gaps = 48/357 (13%)
Query: 40 LQALGLRDEPQGAPRLRPVPPVMWRLFRRRDPQETRSGSRRTSPGVTLQPCHVEELGVAG 99
LQ LGL D+ + +PVP ++ ++F+ R+ T GV+ C+V+ELGV G
Sbjct: 30 LQFLGL-DKAPSPQKFQPVPYILKKIFQDREAAATT--------GVSRDLCYVKELGVRG 80
Query: 100 NIVRHIPDRGA---PTRASEPASAAGHCPEWTVVFDLSAVEPAERPSRARLELRFAAAAA 156
N++R +PD+G P + S+ +S C + + F+LSA++ E+ + A+L L +
Sbjct: 81 NVLRFLPDQGFFLYPKKISQASS----CLQKLLYFNLSAIKEREQLTLAQLGLDLGPNSY 136
Query: 157 --AAPEGGWELSVAQAGQGAGAD---PGPVLLRQLVPALGPPVRAELLGAA--WARNASW 209
PE L + Q G PG + + + VP V LL A W N
Sbjct: 137 YNLGPELELALFLVQEPHVWGQTTPKPGKMFVLRSVPWPQGAVHFNLLDVAKDWNDNPRK 196
Query: 210 PRSLRLALALRPRAPAA--------CARLA---EASLLLVTLDPRLCHPLARPRRDAEPV 258
L L + ++ + CARL ASLL+VTL+P CHP +R RR A PV
Sbjct: 197 NFGLFLEILVKEDRDSGVNFQPEDTCARLRCSLHASLLVVTLNPDQCHP-SRKRRAAIPV 255
Query: 259 LGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQC--ALPVALSGSGGPPALN 316
C +L+++FR++GWH+W+IAP+GF+ANYC G+C +L ++L+ S N
Sbjct: 256 PKLSCKNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSS------N 309
Query: 317 HAVLRALMHAAAPGAADLP--CCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371
+A ++ALMHA P ++P C+P +LSPIS+L+ DN+DNV+LR YEDMVVDECGC
Sbjct: 310 YAFMQALMHAVDP---EIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGC 363
>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
sapiens]
Length = 513
Score = 120 bits (300), Expect = 3e-27
Identities = 50/106 (47%), Positives = 73/106 (68%), Gaps = 4/106 (3%)
Query: 266 ACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMH 325
ACR LYVSF+++GW W+IAP+G+ ANYC G+C+ P+ + A NHA+++ L+H
Sbjct: 411 ACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPL----NAHMNATNHAIVQTLVH 466
Query: 326 AAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371
P PCC P +L+ ISVL+FD++ NV+L++Y +MVV CGC
Sbjct: 467 LMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
>gi|61835232 growth differentiation factor 7 preproprotein [Homo
sapiens]
Length = 450
Score = 120 bits (300), Expect = 3e-27
Identities = 101/299 (33%), Positives = 133/299 (44%), Gaps = 50/299 (16%)
Query: 113 RASEPASAAGHCPEWTV--VFDLSAVEPAERPSRARLELRFAAAAAAAPEGGWE-LSVAQ 169
R P S G WT + LS A R R L ++ AA WE VA
Sbjct: 163 RRGSPESGPG---SWTSPPLLLLSTCPGAARAPR----LLYSRAAEPLVGQRWEAFDVAD 215
Query: 170 AGQGAGADPGP-----VLLRQLVPALGPPVRAELLGAAWARNASWPRSLRLALA------ 218
A + +P P +LLR + + P+ LG W R L
Sbjct: 216 AMRRHRREPRPPRAFCLLLRAVAGPVPSPLALRRLGFGWPGGGGSAAEERAVLVVSSRTQ 275
Query: 219 --------LRPRAPAACARLAEASLL---LVTLDPRLCHPLARPRRDA------EPVLGG 261
+R +A A A LA L T PR R RR A GG
Sbjct: 276 RKESLFREIRAQARALGAALASEPLPDPGTGTASPRAVIGGRRRRRTALAGTRTAQGSGG 335
Query: 262 GPG--------GACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPP 313
G G C + L+V F+E+GW W+IAP + A +C+G C P+ S P
Sbjct: 336 GAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLR---SHLEP 392
Query: 314 ALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR 372
NHA+++ L+++ AP AA CCVPARLSPIS+L+ D ++NVV +QYEDMVV+ CGCR
Sbjct: 393 T-NHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR 450
>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
Length = 431
Score = 119 bits (298), Expect = 4e-27
Identities = 51/106 (48%), Positives = 72/106 (67%), Gaps = 4/106 (3%)
Query: 266 ACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMH 325
AC+ LYVSFR++GW W+IAP G+ A YC+G+CA P+ + A NHA+++ L+H
Sbjct: 329 ACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPL----NSYMNATNHAIVQTLVH 384
Query: 326 AAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371
P PCC P +L+ ISVL+FD+S NV+L++Y +MVV CGC
Sbjct: 385 FINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
sapiens]
Length = 454
Score = 118 bits (295), Expect = 1e-26
Identities = 50/106 (47%), Positives = 71/106 (66%), Gaps = 4/106 (3%)
Query: 266 ACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMH 325
AC+ LYVSFR++GW W+IAP G+ A YC G+C+ P+ + A NHA+++ L+H
Sbjct: 352 ACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPL----NAHMNATNHAIVQTLVH 407
Query: 326 AAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371
P PCC P +L+ ISVL+FD+S NV+L++Y +MVV CGC
Sbjct: 408 LMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
Length = 402
Score = 117 bits (293), Expect = 2e-26
Identities = 73/203 (35%), Positives = 101/203 (49%), Gaps = 30/203 (14%)
Query: 173 GAGADPGPV-LLRQLVPALGPPVRAELLGAAWARNASWPRSLRLALALRP---RAPAACA 228
G DPG LL Q P P A+ P +R A+RP R P
Sbjct: 225 GHSVDPGLAGLLGQRAPRSQQPFVVTFFRAS-------PSPIRTPRAVRPLRRRQPKKSN 277
Query: 229 RLAEASLLLVTLDPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAP 288
L +A+ L D V G CR LYVSF+++GW WVIAP
Sbjct: 278 ELPQANRLPGIFDD---------------VRGSHGRQVCRRHELYVSFQDLGWLDWVIAP 322
Query: 289 RGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVL 348
+G+ A YC+G+C+ P+ + A NHA+L++L+H P A CC P +LS SVL
Sbjct: 323 QGYSAYYCEGECSFPLDSCMN----ATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVL 378
Query: 349 FFDNSDNVVLRQYEDMVVDECGC 371
++D+S+NV+LR++ +MVV CGC
Sbjct: 379 YYDSSNNVILRKHRNMVVKACGC 401
>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
sapiens]
Length = 402
Score = 116 bits (291), Expect = 3e-26
Identities = 73/203 (35%), Positives = 101/203 (49%), Gaps = 30/203 (14%)
Query: 173 GAGADPGPV-LLRQLVPALGPPVRAELLGAAWARNASWPRSLRLALALRP---RAPAACA 228
G DPG LL Q P P A+ P +R A+RP R P
Sbjct: 225 GHSVDPGLAGLLGQRAPRSQQPFVVTFFRAS-------PSPIRTPRAVRPLRRRQPKKSN 277
Query: 229 RLAEASLLLVTLDPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAP 288
L +A+ L D V G CR LYVSF+++GW WVIAP
Sbjct: 278 ELPQANRLPGIFDD---------------VHGSHGRQVCRRHELYVSFQDLGWLDWVIAP 322
Query: 289 RGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVL 348
+G+ A YC+G+C+ P+ + A NHA+L++L+H P A CC P +LS SVL
Sbjct: 323 QGYSAYYCEGECSFPLDSCMN----ATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVL 378
Query: 349 FFDNSDNVVLRQYEDMVVDECGC 371
++D+S+NV+LR++ +MVV CGC
Sbjct: 379 YYDSSNNVILRKHRNMVVKACGC 401
>gi|4503969 growth differentiation factor 5 preproprotein [Homo
sapiens]
Length = 501
Score = 110 bits (276), Expect = 2e-24
Identities = 120/411 (29%), Positives = 167/411 (40%), Gaps = 99/411 (24%)
Query: 24 LPLTRAPVPPG--PAAALLQAL---GLRDEPQGAPRLRPVPP--VMWRLFRRRDPQETRS 76
LP +AP G P++ LL+ G EP+ R P+ P M L+R + +
Sbjct: 128 LPGGKAPPKAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKG 187
Query: 77 GSRRTSPGVTLQPCHVEELGVAGNIVRHIP----DRGAPTRASEPASAAGHCPEWTVVFD 132
G+ E G+A I I DRG R VFD
Sbjct: 188 GNSSVKL----------EAGLANTITSFIDKGQDDRGPVVRKQR------------YVFD 225
Query: 133 LSAVEPAERPSRARLELRFA------AAAAAAPEGGWELSVAQAGQGAGADPGPVLLRQL 186
+SA+E + ELR A AAP GG + + +G P +L +
Sbjct: 226 ISALE---KDGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPASLLDVRS 282
Query: 187 VPALGPPVRAELLGAAWARNASWP------RSLRLALAL----RPRA--------PAACA 228
VP L G+ W W S +L L L R RA A
Sbjct: 283 VPGLD--------GSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFDRAAR 334
Query: 229 RLAEASLLLV-------------------TLDPRLCHPLARPRRDAEPVLGGGPG----- 264
++ E +L LV D + L RR L G
Sbjct: 335 QVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSK 394
Query: 265 ---GACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLR 321
C + L+V+F+++GW W+IAP + A +C+G C P+ S P NHAV++
Sbjct: 395 NLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLR---SHLEPT-NHAVIQ 450
Query: 322 ALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR 372
LM++ P + CCVP RLSPIS+LF D+++NVV +QYEDMVV+ CGCR
Sbjct: 451 TLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501
>gi|48475062 growth differentiation factor 6 precursor [Homo
sapiens]
Length = 455
Score = 109 bits (272), Expect = 5e-24
Identities = 58/136 (42%), Positives = 81/136 (59%), Gaps = 9/136 (6%)
Query: 242 PRLCHPLARPRRDAEPVLGGGPGGA-----CRARRLYVSFREVGWHRWVIAPRGFLANYC 296
P L P R RR A G G C + L+V+F+E+GW W+IAP + A +C
Sbjct: 324 PWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHC 383
Query: 297 QGQCALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNV 356
+G C P+ S P NHA+++ LM++ PG+ CCVP +L+PIS+L+ D +NV
Sbjct: 384 EGVCDFPLR---SHLEPT-NHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNV 439
Query: 357 VLRQYEDMVVDECGCR 372
V +QYEDMVV+ CGCR
Sbjct: 440 VYKQYEDMVVESCGCR 455
>gi|4504699 inhibin beta A precursor [Homo sapiens]
Length = 426
Score = 101 bits (252), Expect = 9e-22
Identities = 47/128 (36%), Positives = 77/128 (60%), Gaps = 7/128 (5%)
Query: 246 HPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVA 305
HP R RR E G C ++ +VSF+++GW+ W+IAP G+ ANYC+G+C P
Sbjct: 303 HPHRRRRRGLEC---DGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGEC--PSH 357
Query: 306 LSGSGGPPALNHAVL--RALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYED 363
++G+ G H+ + M +P A CCVP +L P+S+L++D+ N++ + ++
Sbjct: 358 IAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQN 417
Query: 364 MVVDECGC 371
M+V+ECGC
Sbjct: 418 MIVEECGC 425
>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
sapiens]
Length = 396
Score = 101 bits (252), Expect = 9e-22
Identities = 52/130 (40%), Positives = 80/130 (61%), Gaps = 10/130 (7%)
Query: 246 HPL-ARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPV 304
HPL R +R A+ +C+ LYV F +VGW+ W++AP G+ A YC G+C P+
Sbjct: 274 HPLHKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPL 333
Query: 305 ALSGSGGPPALNHAVLRALMHAAAPGAADLP--CCVPARLSPISVLFFDNSDNVVLRQYE 362
A + + NHA+++ L+++ + +P CCVP LS IS+L+ D ++ VVL+ Y+
Sbjct: 334 ADHLN----STNHAIVQTLVNSVN---SKIPKACCVPTELSAISMLYLDENEKVVLKNYQ 386
Query: 363 DMVVDECGCR 372
DMVV+ CGCR
Sbjct: 387 DMVVEGCGCR 396
>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 100 bits (248), Expect = 3e-21
Identities = 46/106 (43%), Positives = 66/106 (62%), Gaps = 5/106 (4%)
Query: 267 CRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHA 326
CR LYV F +VGW+ W++AP G+ A YC G C P+A + NHA+++ L++
Sbjct: 308 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLA----DHLNSTNHAIVQTLVN- 362
Query: 327 AAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR 372
+ + CCVP LS IS+L+ D D VVL+ Y++MVV+ CGCR
Sbjct: 363 SVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 100 bits (248), Expect = 3e-21
Identities = 46/106 (43%), Positives = 66/106 (62%), Gaps = 5/106 (4%)
Query: 267 CRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHA 326
CR LYV F +VGW+ W++AP G+ A YC G C P+A + NHA+++ L++
Sbjct: 308 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLA----DHLNSTNHAIVQTLVN- 362
Query: 327 AAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR 372
+ + CCVP LS IS+L+ D D VVL+ Y++MVV+ CGCR
Sbjct: 363 SVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 100 bits (248), Expect = 3e-21
Identities = 46/106 (43%), Positives = 66/106 (62%), Gaps = 5/106 (4%)
Query: 267 CRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHA 326
CR LYV F +VGW+ W++AP G+ A YC G C P+A + NHA+++ L++
Sbjct: 308 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLA----DHLNSTNHAIVQTLVN- 362
Query: 327 AAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR 372
+ + CCVP LS IS+L+ D D VVL+ Y++MVV+ CGCR
Sbjct: 363 SVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
>gi|13899338 activin beta E [Homo sapiens]
Length = 350
Score = 98.2 bits (243), Expect = 1e-20
Identities = 46/105 (43%), Positives = 62/105 (59%), Gaps = 2/105 (1%)
Query: 267 CRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHA 326
C R YV F+E+GW W++ P G+ NYC GQC P L+GS G A H+ + +L+ A
Sbjct: 247 CCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQC--PPHLAGSPGIAASFHSAVFSLLKA 304
Query: 327 AAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371
P A CCVP P+S+L+ D++ NVV DMVV+ CGC
Sbjct: 305 NNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGC 349
>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
sapiens]
Length = 472
Score = 97.1 bits (240), Expect = 2e-20
Identities = 45/108 (41%), Positives = 65/108 (60%), Gaps = 7/108 (6%)
Query: 267 CRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHA 326
C R L V F ++GW W+I+P+ F A YC G C P+ S NHA +++++ A
Sbjct: 370 CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPS----NHATIQSIVRA 425
Query: 327 AA--PGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR 372
PG + PCCVP ++S +S+LFFD + NVVL+ Y +M V+ C CR
Sbjct: 426 VGVVPGIPE-PCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472
>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
sapiens]
Length = 424
Score = 96.3 bits (238), Expect = 4e-20
Identities = 49/124 (39%), Positives = 68/124 (54%), Gaps = 11/124 (8%)
Query: 249 ARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSG 308
AR RR+A+ G C+ LY+ F+E+GW W+IAP G+ A C+G C P+A
Sbjct: 312 ARIRRNAK-------GNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHL 364
Query: 309 SGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDE 368
+ HA+++AL+H A CCVP +L PIS+L+ D +YE M V E
Sbjct: 365 T----PTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSE 420
Query: 369 CGCR 372
CGCR
Sbjct: 421 CGCR 424
>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
Length = 352
Score = 93.2 bits (230), Expect = 3e-19
Identities = 46/113 (40%), Positives = 63/113 (55%), Gaps = 5/113 (4%)
Query: 261 GGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVL 320
GG CR + +V FRE+GWH W+I P G+ N+C GQC P+ ++G G A H +
Sbjct: 242 GGSRMCCR-QEFFVDFREIGWHDWIIQPEGYAMNFCIGQC--PLHIAGMPGIAASFHTAV 298
Query: 321 RALMHA--AAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371
L+ A AA CCVP P+S+L++D N+V DMVV+ CGC
Sbjct: 299 LNLLKANTAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGC 351
>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
Length = 407
Score = 92.8 bits (229), Expect = 4e-19
Identities = 42/112 (37%), Positives = 66/112 (58%), Gaps = 5/112 (4%)
Query: 262 GPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVL- 320
G C ++ ++ FR +GW+ W+IAP G+ NYC+G C P L+G G + H +
Sbjct: 298 GRTNLCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSC--PAYLAGVPGSASSFHTAVV 355
Query: 321 -RALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371
+ M PG + CC+P +LS +S+L+FD+ N+V R +M+V+ECGC
Sbjct: 356 NQYRMRGLNPGTVN-SCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 406
>gi|4826740 growth differentiation factor 10 precursor [Homo
sapiens]
Length = 478
Score = 92.0 bits (227), Expect = 7e-19
Identities = 68/223 (30%), Positives = 102/223 (45%), Gaps = 29/223 (13%)
Query: 157 AAPEGGWELSVAQAGQGAGADPGPVLLRQLVPALGPPVRAELLGAAWARNASWPRSLRLA 216
AAP + V +A Q G P+ +L P RA + ++ WP R
Sbjct: 278 AAPNNSADPRVRRAAQATG----PLQDNELPGLDERPPRAH--AQHFHKHQLWPSPFR-- 329
Query: 217 LALRPRAPAACAR-----LAEASLLLVTLDPRLCHPLARPRRDAEPVLGGGPGGACRARR 271
AL+PR R + A+ ++ D + R + D V C R
Sbjct: 330 -ALKPRPGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRV--------CSRRY 380
Query: 272 LYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHAAA--P 329
L V F ++GW+ W+I+P+ F A YC G C P+ NHA +++++ A P
Sbjct: 381 LKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPS----NHATIQSIVRAVGIIP 436
Query: 330 GAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR 372
G + PCCVP +++ + VLF D + NVVL+ Y +M VD C CR
Sbjct: 437 GIPE-PCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478
>gi|7705308 growth differentiation factor 2 [Homo sapiens]
Length = 429
Score = 91.7 bits (226), Expect = 1e-18
Identities = 50/126 (39%), Positives = 68/126 (53%), Gaps = 11/126 (8%)
Query: 248 LARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALS 307
LAR +R A G G C+ L V+F ++GW W+IAP+ + A C+G C P+A
Sbjct: 314 LARRKRSA------GAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLA-- 365
Query: 308 GSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLR-QYEDMVV 366
HA+++ L+H P CCVP +LSPISVL+ D+ L+ YE M V
Sbjct: 366 --DDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSV 423
Query: 367 DECGCR 372
ECGCR
Sbjct: 424 AECGCR 429
>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
Length = 392
Score = 85.5 bits (210), Expect = 7e-17
Identities = 39/112 (34%), Positives = 61/112 (54%), Gaps = 4/112 (3%)
Query: 261 GGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVL 320
G C +SFR++GW W+IAP + NYC+G C L V G P NHA++
Sbjct: 285 GPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTC-LRVLRDGLNSP---NHAII 340
Query: 321 RALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR 372
+ L++ + P CVP + PISVL + + +++ ++YE M+ + C CR
Sbjct: 341 QNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR 392
>gi|222352098 nodal precursor [Homo sapiens]
Length = 347
Score = 81.6 bits (200), Expect = 1e-15
Identities = 39/105 (37%), Positives = 59/105 (56%), Gaps = 5/105 (4%)
Query: 267 CRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHA 326
CR + V F +GW W+I P+ + A C+G+C PV G P NHA +++L+
Sbjct: 247 CRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPV---GEEFHPT-NHAYIQSLLKR 302
Query: 327 AAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371
P CC P + P+S+L+ DN V+L ++DM+V+ECGC
Sbjct: 303 YQPHRVPSTCCAPVKTKPLSMLYVDNG-RVLLDHHKDMIVEECGC 346
>gi|153792495 growth differentiation factor 15 [Homo sapiens]
Length = 308
Score = 80.1 bits (196), Expect = 3e-15
Identities = 61/182 (33%), Positives = 80/182 (43%), Gaps = 26/182 (14%)
Query: 208 SWP--RSLRLALAL-RPRAPAACARL-----------AEASLLLVTLDPRLCHPLARPRR 253
SW R LR L+L RP+APA RL AE+S L+ L AR RR
Sbjct: 134 SWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQLELHLRPQAARGRR 193
Query: 254 DAEPVLGG----GPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGS 309
A G GPG CR + S ++GW WV++PR C G C S
Sbjct: 194 RARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACP-------S 246
Query: 310 GGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDEC 369
A HA ++ +H P PCCVPA +P+ VL V L+ Y+D++ +C
Sbjct: 247 QFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDC 305
Query: 370 GC 371
C
Sbjct: 306 HC 307
>gi|239757187 PREDICTED: similar to growth differentiation factor 15
[Homo sapiens]
Length = 270
Score = 80.1 bits (196), Expect = 3e-15
Identities = 61/182 (33%), Positives = 80/182 (43%), Gaps = 26/182 (14%)
Query: 208 SWP--RSLRLALAL-RPRAPAACARL-----------AEASLLLVTLDPRLCHPLARPRR 253
SW R LR L+L RP+APA RL AE+S L+ L AR RR
Sbjct: 96 SWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQLELHLRPQAARGRR 155
Query: 254 DAEPVLGG----GPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGS 309
A G GPG CR + S ++GW WV++PR C G C S
Sbjct: 156 RARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACP-------S 208
Query: 310 GGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDEC 369
A HA ++ +H P PCCVPA +P+ VL V L+ Y+D++ +C
Sbjct: 209 QFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDC 267
Query: 370 GC 371
C
Sbjct: 268 HC 269
>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
Length = 454
Score = 77.8 bits (190), Expect = 1e-14
Identities = 34/110 (30%), Positives = 58/110 (52%), Gaps = 4/110 (3%)
Query: 263 PGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRA 322
P C +SF ++ W W++AP + YC+G C P A+ G P H +++
Sbjct: 349 PQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDC--PRAVGHRYGSPV--HTMVQN 404
Query: 323 LMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR 372
+++ + P CVPA+ SP+SVL + ++ ++YEDM+ +C CR
Sbjct: 405 IIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
>gi|4885259 myostatin [Homo sapiens]
Length = 375
Score = 74.7 bits (182), Expect = 1e-13
Identities = 37/105 (35%), Positives = 53/105 (50%), Gaps = 11/105 (10%)
Query: 267 CRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHA 326
C L V F GW W+IAP+ + ANYC G+C L L+H
Sbjct: 281 CCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVF----------LQKYPHTHLVHQ 329
Query: 327 AAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371
A P + PCC P ++SPI++L+F+ + ++ + MVVD CGC
Sbjct: 330 ANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374
>gi|5031613 growth differentiation factor 11 precursor [Homo
sapiens]
Length = 407
Score = 71.6 bits (174), Expect = 1e-12
Identities = 36/105 (34%), Positives = 52/105 (49%), Gaps = 11/105 (10%)
Query: 267 CRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHA 326
C L V F GW W+IAP+ + ANYC GQC + L+
Sbjct: 313 CCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMF----------MQKYPHTHLVQQ 361
Query: 327 AAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371
A P + PCC P ++SPI++L+F++ ++ + MVVD CGC
Sbjct: 362 ANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
Length = 412
Score = 67.8 bits (164), Expect = 2e-11
Identities = 38/106 (35%), Positives = 55/106 (51%), Gaps = 10/106 (9%)
Query: 267 CRARRLYVSFRE-VGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMH 325
C R LY+ FR+ +GW +WV P+G+ AN+C G C P S H+ + L +
Sbjct: 315 CCVRPLYIDFRQDLGW-KWVHEPKGYYANFCSGPC--PYLRSAD-----TTHSTVLGLYN 366
Query: 326 AAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371
P A+ PCCVP L P+++L++ V Q +MVV C C
Sbjct: 367 TLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.448
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,780,024
Number of Sequences: 37866
Number of extensions: 1110283
Number of successful extensions: 4600
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 138
Number of HSP's that attempted gapping in prelim test: 4388
Number of HSP's gapped (non-prelim): 295
length of query: 372
length of database: 18,247,518
effective HSP length: 104
effective length of query: 268
effective length of database: 14,309,454
effective search space: 3834933672
effective search space used: 3834933672
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.