Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 156142199

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
         (1176 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is...  2410   0.0  
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is...  2393   0.0  
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is...  1082   0.0  
gi|224465235 euchromatic histone-lysine N-methyltransferase 1 is...   352   1e-96
gi|13375930 suppressor of variegation 3-9 homolog 2 [Homo sapiens]    155   2e-37
gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens]     153   8e-37
gi|194306650 SET domain and mariner transposase fusion [Homo sap...   139   1e-32
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   128   4e-29
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        120   8e-27
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   120   1e-26
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       117   6e-26
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        117   6e-26
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        117   6e-26
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        117   6e-26
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        117   6e-26
gi|55742857 ankyrin repeat domain 6 [Homo sapiens]                    117   6e-26
gi|224177469 SET domain, bifurcated 1 isoform 2 [Homo sapiens]        112   2e-24
gi|224177467 SET domain, bifurcated 1 isoform 1 [Homo sapiens]        112   2e-24
gi|34304381 inversin isoform a [Homo sapiens]                         112   3e-24
gi|34304379 inversin isoform b [Homo sapiens]                         112   3e-24
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   110   8e-24
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   110   8e-24
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    109   1e-23
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   108   3e-23
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       108   3e-23
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        108   3e-23
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        108   3e-23
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   107   7e-23
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   107   7e-23
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  107   9e-23

>gi|156142199 euchromatic histone-lysine N-methyltransferase 2 isoform
            b [Homo sapiens]
          Length = 1176

 Score = 2410 bits (6247), Expect = 0.0
 Identities = 1176/1176 (100%), Positives = 1176/1176 (100%)

Query: 1    MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE 60
            MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE
Sbjct: 1    MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE 60

Query: 61   PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP 120
            PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP
Sbjct: 61   PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP 120

Query: 121  SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV 180
            SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV
Sbjct: 121  SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV 180

Query: 181  HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL 240
            HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL
Sbjct: 181  HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL 240

Query: 241  GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE 300
            GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE
Sbjct: 241  GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE 300

Query: 301  EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR 360
            EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR
Sbjct: 301  EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR 360

Query: 361  KREPPRAKEPRGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDG 420
            KREPPRAKEPRGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDG
Sbjct: 361  KREPPRAKEPRGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDG 420

Query: 421  ELSGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFR 480
            ELSGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFR
Sbjct: 421  ELSGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFR 480

Query: 481  VAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPG 540
            VAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPG
Sbjct: 481  VAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPG 540

Query: 541  RADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEK 600
            RADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEK
Sbjct: 541  RADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEK 600

Query: 601  ALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQ 660
            ALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQ
Sbjct: 601  ALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQ 660

Query: 661  KGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTC 720
            KGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTC
Sbjct: 661  KGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTC 720

Query: 721  LHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLT 780
            LHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLT
Sbjct: 721  LHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLT 780

Query: 781  DNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRG 840
            DNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRG
Sbjct: 781  DNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRG 840

Query: 841  ANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVP 900
            ANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVP
Sbjct: 841  ANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVP 900

Query: 901  IPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRC 960
            IPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRC
Sbjct: 901  IPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRC 960

Query: 961  WYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRA 1020
            WYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRA
Sbjct: 961  WYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRA 1020

Query: 1021 LQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHL 1080
            LQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHL
Sbjct: 1021 LQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHL 1080

Query: 1081 CDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEK 1140
            CDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEK
Sbjct: 1081 CDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEK 1140

Query: 1141 CKHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT 1176
            CKHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT
Sbjct: 1141 CKHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT 1176


>gi|156142197 euchromatic histone-lysine N-methyltransferase 2 isoform
            a [Homo sapiens]
          Length = 1210

 Score = 2393 bits (6202), Expect = 0.0
 Identities = 1176/1210 (97%), Positives = 1176/1210 (97%), Gaps = 34/1210 (2%)

Query: 1    MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE 60
            MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE
Sbjct: 1    MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE 60

Query: 61   PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP 120
            PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP
Sbjct: 61   PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP 120

Query: 121  SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV 180
            SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV
Sbjct: 121  SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV 180

Query: 181  HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL 240
            HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL
Sbjct: 181  HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL 240

Query: 241  GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE 300
            GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE
Sbjct: 241  GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE 300

Query: 301  EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR 360
            EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR
Sbjct: 301  EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR 360

Query: 361  KREPPRAKEPRGV----------------------------------SNDTSSLETERGF 386
            KREPPRAKEPRGV                                  SNDTSSLETERGF
Sbjct: 361  KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF 420

Query: 387  EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL 446
            EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL
Sbjct: 421  EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL 480

Query: 447  CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA 506
            CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA
Sbjct: 481  CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA 540

Query: 507  SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA 566
            SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA
Sbjct: 541  SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA 600

Query: 567  DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ 626
            DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ
Sbjct: 601  DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ 660

Query: 627  GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT 686
            GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT
Sbjct: 661  GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT 720

Query: 687  PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA 746
            PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA
Sbjct: 721  PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA 780

Query: 747  QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA 806
            QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA
Sbjct: 781  QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA 840

Query: 807  RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA 866
            RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA
Sbjct: 841  RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA 900

Query: 867  LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS 926
            LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS
Sbjct: 901  LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS 960

Query: 927  TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA 986
            TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA
Sbjct: 961  TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA 1020

Query: 987  CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR 1046
            CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR
Sbjct: 1021 CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR 1080

Query: 1047 EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS 1106
            EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS
Sbjct: 1081 EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS 1140

Query: 1107 SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP 1166
            SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP
Sbjct: 1141 SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP 1200

Query: 1167 ELGSLPPVNT 1176
            ELGSLPPVNT
Sbjct: 1201 ELGSLPPVNT 1210


>gi|224465233 euchromatic histone-lysine N-methyltransferase 1 isoform
            1 [Homo sapiens]
          Length = 1298

 Score = 1082 bits (2798), Expect = 0.0
 Identities = 562/1176 (47%), Positives = 737/1176 (62%), Gaps = 144/1176 (12%)

Query: 108  LLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEP 167
            L GHA K+ P    KG     R   +      +PP+              +G+A      
Sbjct: 147  LPGHAAKTLPGGAGKG-----RTPSAFPQTPAAPPATLG-----------EGSADTEDRK 190

Query: 168  PPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFR-MSDDVHSLGKVTSDLAK 226
             PA   P    KVHRARKTM K   G      K P E++  R   +    + K  SD  +
Sbjct: 191  LPA---PGADVKVHRARKTMPKSVVGLHAA-SKDPREVREARDHKEPKEEINKNISDFGR 246

Query: 227  RRKLNSGGGLSEELGS---------------------------ARRSGEVTLTKGDPGSL 259
            ++ L     L + L                              RR G  +L       +
Sbjct: 247  QQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKV 306

Query: 260  EEWETVV--------------GDD----FSLYYDSYSVDERVDSDSKSEVEA-------- 293
             +  TV+              G+      SL+ +  S++   D D   E+E         
Sbjct: 307  LKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDDGHGAEQ 366

Query: 294  ----------LTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA- 342
                       +++   E +  ++ + E EEE+E  +  E+EE G++SD S  S  +K  
Sbjct: 367  AAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSESSIKKKF 426

Query: 343  -KKKWRKDSPWVKPSRKRRKREPPR----------------------------------- 366
             K+K + DSPW+KP+RKRR+R   +                                   
Sbjct: 427  LKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVSLDS 486

Query: 367  ---------AKEPRGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATES 417
                     + +  G++N    LET+ G +E+PLCSCRME PK   I+  A ++CMATES
Sbjct: 487  LDLRVKGILSSQAEGLANGPDVLETD-GLQEVPLCSCRMETPKSREITTLANNQCMATES 545

Query: 418  VDGELSGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHP 477
            VD EL  C  +++K E MRPS++  L+VLCE HR RMVKH CCPGCGYFCTAG F+EC P
Sbjct: 546  VDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQP 605

Query: 478  DFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAP-PPLSQ 536
            +  ++HRFHK C S++N   +CPHCGE++S+A+EVTI + D  +    T  P P      
Sbjct: 606  ESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTS----TVTPVPGQEKGS 661

Query: 537  DVPGRADTSQPSAR--MRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPG 594
             + GRADT+  SA        +  +     + +  D +GP+     G      GL  GPG
Sbjct: 662  ALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPA-----GLGRPTPGLSQGPG 716

Query: 595  REALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTP 654
            +E LE AL+  +SE+ KKLRFHP+QLY S +QGELQKV+LML+D +DPNF+ + Q+KR+P
Sbjct: 717  KETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSP 776

Query: 655  LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 714
            LHAAA+ G V+ICH+L+QAGANI+   + QRTPLMEA  NNHLE  +Y+++ G  V  K+
Sbjct: 777  LHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKD 836

Query: 715  EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 774
             +GSTCLH AAK G+ E+V  LLS GQ+DVN QD GGWTP+IWA E+KH++++++LL++G
Sbjct: 837  AEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKG 896

Query: 775  ADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVL 834
            +D+ + DNEENICLHWA+F+G   IAE+LL A+CDLHAVN HGD+PLHIAARE+ +DCV+
Sbjct: 897  SDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVV 956

Query: 835  LFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVAR 894
            LFLSR ++  L+NKEG+T        S VW ALQ+++ L+    +R    E+I+ RD+AR
Sbjct: 957  LFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIAR 1016

Query: 895  GYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCG 954
            GYE +PIPCVN VD EPCP +YKY+S+NC TS MNIDRNITHLQ+C C+DDCSSSNC+CG
Sbjct: 1017 GYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCG 1076

Query: 955  QLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKM 1014
            QLS+RCWYDKDGRLL EFN  EPPLIFECN ACSCWRNC+NRVVQ+G++ RLQLYRT  M
Sbjct: 1077 QLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDM 1136

Query: 1015 GWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNIS 1074
            GWGVR+LQ IP GTF+CEYVGELISD+EADVRE+DSYLFDLDNKDGEVYCIDAR+YGN+S
Sbjct: 1137 GWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVS 1196

Query: 1075 RFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTC 1134
            RFINH C+PN++PVRVFM HQDLRFPRIAFFS+R I  GE+LGFDYG+RFWDIK K F+C
Sbjct: 1197 RFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSC 1256

Query: 1135 QCGSEKCKHSAEAIALEQSRLARLDPHPELLPELGS 1170
            +CGS KC+HS+ A+A  Q+  A+ +   + LP+  S
Sbjct: 1257 RCGSPKCRHSSAALAQRQASAAQ-EAQEDGLPDTSS 1291


>gi|224465235 euchromatic histone-lysine N-methyltransferase 1
           isoform 2 [Homo sapiens]
          Length = 808

 Score =  352 bits (903), Expect = 1e-96
 Identities = 232/678 (34%), Positives = 328/678 (48%), Gaps = 143/678 (21%)

Query: 108 LLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEP 167
           L GHA K+ P    KG     R   +      +PP+              +G+A      
Sbjct: 147 LPGHAAKTLPGGAGKG-----RTPSAFPQTPAAPPATLG-----------EGSADTEDRK 190

Query: 168 PPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFR-MSDDVHSLGKVTSDLAK 226
            PA   P    KVHRARKTM K   G      K P E++  R   +    + K  SD  +
Sbjct: 191 LPA---PGADVKVHRARKTMPKSVVGLHAA-SKDPREVREARDHKEPKEEINKNISDFGR 246

Query: 227 RRKLNSGGGLSEELGS---------------------------ARRSGEVTLTKGDPGSL 259
           ++ L     L + L                              RR G  +L       +
Sbjct: 247 QQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKV 306

Query: 260 EEWETVV--------------GDD----FSLYYDSYSVDERVDSDSKSEVEA-------- 293
            +  TV+              G+      SL+ +  S++   D D   E+E         
Sbjct: 307 LKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDDGHGAEQ 366

Query: 294 ----------LTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA- 342
                      +++   E +  ++ + E EEE+E  +  E+EE G++SD S  S  +K  
Sbjct: 367 AAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSESSIKKKF 426

Query: 343 -KKKWRKDSPWVKPSRKRRKREPPR----------------------------------- 366
            K+K + DSPW+KP+RKRR+R   +                                   
Sbjct: 427 LKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVSLDS 486

Query: 367 ---------AKEPRGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATES 417
                    + +  G++N    LET+ G +E+PLCSCRME PK   I+  A ++CMATES
Sbjct: 487 LDLRVKGILSSQAEGLANGPDVLETD-GLQEVPLCSCRMETPKSREITTLANNQCMATES 545

Query: 418 VDGELSGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHP 477
           VD EL  C  +++K E MRPS++  L+VLCE HR RMVKH CCPGCGYFCTAG F+EC P
Sbjct: 546 VDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQP 605

Query: 478 DFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAP-PPLSQ 536
           +  ++HRFHK C S++N   +CPHCGE++S+A+EVTI + D       T  P P      
Sbjct: 606 ESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKAD----TTSTVTPVPGQEKGS 661

Query: 537 DVPGRADTSQPSAR--MRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPG 594
            + GRADT+  SA        +  +     + +  D +GP+     G      GL  GPG
Sbjct: 662 ALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPA-----GLGRPTPGLSQGPG 716

Query: 595 REALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTP 654
           +E LE AL+  +SE+ KKLRFHP+QLY S +QGELQKV+LML+D +DPNF+ + Q+KR+P
Sbjct: 717 KETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSP 776

Query: 655 LHAAAQKGSVEICHVLLQ 672
           LHAAA+ G V+ICH+L+Q
Sbjct: 777 LHAAAEAGHVDICHMLVQ 794


>gi|13375930 suppressor of variegation 3-9 homolog 2 [Homo sapiens]
          Length = 350

 Score =  155 bits (392), Expect = 2e-37
 Identities = 98/258 (37%), Positives = 137/258 (53%), Gaps = 29/258 (11%)

Query: 905  NGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDK 964
            N VD E  P D+ YI+E      +++    T    CT   DC    C   +  +   Y+K
Sbjct: 98   NTVDLEGPPSDFYYINEYKPAPGISLVNEATFGCSCT---DCFFQKCCPAEAGVLLAYNK 154

Query: 965  DGRLLQEFNKIEPPL-IFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAK-MGWGVRALQ 1022
            + ++     KI P   I+ECN  C C  +C NR+VQ G +  L ++RT+   GWGV+ L 
Sbjct: 155  NQQI-----KIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLV 209

Query: 1023 TIPQGTFICEYVGELISDAEADVR------EDDSYLFDLDNKDGEVYCIDARYYGNISRF 1076
             I + +F+ EYVGE+I+  EA+ R      +  +YLFDLD +  E + +DA  YGN+S F
Sbjct: 210  KIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDE-FTVDAARYGNVSHF 268

Query: 1077 INHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDY-----GDRFWDI---- 1127
            +NH CDPN+    VF+ + D R PRIA FS+R I  GEEL FDY     GD   D     
Sbjct: 269  VNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHS 328

Query: 1128 ---KSKYFTCQCGSEKCK 1142
               K     C+CG+  C+
Sbjct: 329  PAKKRVRTVCKCGAVTCR 346


>gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens]
          Length = 412

 Score =  153 bits (387), Expect = 8e-37
 Identities = 102/273 (37%), Positives = 141/273 (51%), Gaps = 48/273 (17%)

Query: 905  NGVDGEPCPEDYKYISENCETSTMNIDRNITHLQ---HCTCVDDC---SSSNCLCGQLSI 958
            N VD +  P  + YI+E        +   IT  Q    C C  DC    +  C  G    
Sbjct: 149  NEVDLDGPPRAFVYINE------YRVGEGITLNQVAVGCEC-QDCLWAPTGGCCPGASLH 201

Query: 959  RCWYDKDGRLLQEFNKIEPPL-IFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAK-MGW 1016
            +  Y+  G++     ++   L I+ECN  C C  +C NRVVQ GI+  L ++RT    GW
Sbjct: 202  KFAYNDQGQV-----RLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGW 256

Query: 1017 GVRALQTIPQGTFICEYVGELISDAEADVR------EDDSYLFDLDNKDGEVYCIDARYY 1070
            GVR L+ I + +F+ EYVGE+I+  EA+ R      +  +YLFDLD  + +VY +DA YY
Sbjct: 257  GVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVE-DVYTVDAAYY 315

Query: 1071 GNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDI--- 1127
            GNIS F+NH CDPN+    VF+ + D R PRIAFF++R IR GEEL FDY  +   +   
Sbjct: 316  GNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDME 375

Query: 1128 ------------------KSKYFTCQCGSEKCK 1142
                              K     C+CG+E C+
Sbjct: 376  STRMDSNFGLAGLPGSPKKRVRIECKCGTESCR 408


>gi|194306650 SET domain and mariner transposase fusion [Homo sapiens]
          Length = 684

 Score =  139 bits (351), Expect = 1e-32
 Identities = 90/277 (32%), Positives = 136/277 (49%), Gaps = 37/277 (13%)

Query: 891  DVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDD-CSSS 949
            DVA G EN+P   V        P  ++Y  ++      +ID        C CV   C   
Sbjct: 29   DVACGQENLP---VGAWPPGAAPAPFQYTPDHVVGPGADIDPTQITFPGCICVKTPCLPG 85

Query: 950  NCLCGQLSIRCWYDKDGRL--LQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQ 1007
             C C +      YD +  L  +    K   P +FECN  C C  +C+NRVVQ G++   Q
Sbjct: 86   TCSCLRHGEN--YDDNSCLRDIGSGGKYAEP-VFECNVLCRCSDHCRNRVVQKGLQFHFQ 142

Query: 1008 LYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEA------DVREDDSYLFDLDNK--D 1059
            +++T K GWG+R L+ IP+G F+CEY GE++  +E         + D +Y+  +     +
Sbjct: 143  VFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREHVYN 202

Query: 1060 GEVY--CIDARYYGNISRFINHLCDPNI--IPVRVFMLHQDLRFPRIAFFSSRDIRTGEE 1115
            G+V    +D  Y GNI RF+NH C+PN+  IPVR+     D   P++A F+++DI   EE
Sbjct: 203  GQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRI-----DSMVPKLALFAAKDIVPEEE 257

Query: 1116 LGFDYGDRFWDIK-----------SKYFTCQCGSEKC 1141
            L +DY  R+ ++                 C CG++ C
Sbjct: 258  LSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSC 294


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  128 bits (321), Expect = 4e-29
 Identities = 89/274 (32%), Positives = 137/274 (50%), Gaps = 37/274 (13%)

Query: 612 KLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLL 671
           KLR  P  L  ++  G+  +V  ++    D NFQ ++  KRTPLHAAA  G  EI  +L+
Sbjct: 5   KLRDQP-SLVQAIFNGDPDEVRALIFKKEDVNFQDNE--KRTPLHAAAYLGDAEIIELLI 61

Query: 672 QAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEED--------------- 716
            +GA +NA D +  TPL  AV +   E  + +++    V +++++               
Sbjct: 62  LSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVK 121

Query: 717 ------------------GSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWA 758
                             G T LHHAA  G+ EMV LLLS G  ++NA D      I WA
Sbjct: 122 CAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRG-ANINAFDKKDRRAIHWA 180

Query: 759 AEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGD 818
           A   HIEV+++L++ GA+VT  D +    LH A+ +G  ++ + LL+   D++  N +G+
Sbjct: 181 AYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGN 240

Query: 819 TPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
           TPLH+A        V   +  GA    +N++G T
Sbjct: 241 TPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFT 274



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 66/235 (28%), Positives = 100/235 (42%), Gaps = 2/235 (0%)

Query: 618 RQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANI 677
           R ++ +   G ++ V L++    +   +   +   TPLHAAA  G + +   LL  G ++
Sbjct: 175 RAIHWAAYMGHIEVVKLLVSHGAEVTCKD--KKSYTPLHAAASSGMISVVKYLLDLGVDM 232

Query: 678 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 737
           N  +    TPL  A  N    V   ++  G  V  K E G T LH AA   +  +   LL
Sbjct: 233 NEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 292

Query: 738 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 797
                DVN +   G TP+   A H      + ++  GA +   D   N  LH A+  G  
Sbjct: 293 VGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHE 352

Query: 798 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
            +   L+ +  D      HG  PLH+AA   + DC    LS G + +  +  G T
Sbjct: 353 LLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRT 407



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 57/201 (28%), Positives = 101/201 (50%), Gaps = 2/201 (0%)

Query: 653 TPLHAAAQKGSVEIC-HVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 711
           TPLH AA      +C  +L+  GA++N   K  +TPL    ++     ++ ++Q G  + 
Sbjct: 274 TPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVID 333

Query: 712 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL 771
            ++++G+T LH AA+ G+  +++ L+++G  D   +   G  P+  AA     +  R LL
Sbjct: 334 CEDKNGNTPLHIAARYGHELLINTLITSG-ADTAKRGIHGMFPLHLAALSGFSDCCRKLL 392

Query: 772 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 831
           + G D+   D+    CLH A+  G+     +LLN   D +  +  G +PLH AA    + 
Sbjct: 393 SSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQ 452

Query: 832 CVLLFLSRGANPELRNKEGDT 852
           C+   +  GA+    ++ G T
Sbjct: 453 CLFALVGSGASVNDLDERGCT 473



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 65/225 (28%), Positives = 106/225 (47%), Gaps = 8/225 (3%)

Query: 635 MLLDNLDPNFQSDQQ--SKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 692
           +L+ N +P    D Q  + +TPL  +   G  +  + LL  GAN++A DK  RT L    
Sbjct: 635 LLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGA 694

Query: 693 VNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMV-SLLLSTGQVDVN--AQDS 749
           V  H E    ++Q G     ++  G T +H +A  G++ ++ +LL S   +D N    D+
Sbjct: 695 VTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADN 754

Query: 750 GGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLN--AR 807
            G+T + WA  + H   + +LL +      T+      LH A    +   AE+L++    
Sbjct: 755 HGYTALHWACYNGHETCVELLLEQEV-FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGA 813

Query: 808 CDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
             ++A +  G TPLH AA   + +C+ L LS  A     +  G T
Sbjct: 814 SIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKT 858



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 70/244 (28%), Positives = 112/244 (45%), Gaps = 11/244 (4%)

Query: 619 QLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 678
           +L L +   E    +LM     D    SD ++  +PLH AA  G  +   VL+Q+  +++
Sbjct: 518 RLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLD 577

Query: 679 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEED-GSTCLHHAAKIGNLEMVSLLL 737
             +   RTPL  A    H+E    ++ +G  +  K+     T +H AA  G+ E + LL+
Sbjct: 578 VRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLI 637

Query: 738 STG--QVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTG 795
                Q  V+ QD  G TP++ +  + H + +  LL +GA+V   D      LH  + TG
Sbjct: 638 GNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTG 697

Query: 796 SAAIAEVLL--NARCDLHAVNYHGDTPLHIAARESYHDCVLLFL----SRGANPELRNKE 849
                + LL   A+C L   +  G TP+H++A   +   +   L    S  ANP   +  
Sbjct: 698 HEECVDALLQHGAKCLLR--DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNH 755

Query: 850 GDTA 853
           G TA
Sbjct: 756 GYTA 759



 Score = 84.7 bits (208), Expect = 5e-16
 Identities = 73/261 (27%), Positives = 119/261 (45%), Gaps = 14/261 (5%)

Query: 594 GREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 653
           G E L   L+   ++  K+       L+L+   G       +L    D +   D    RT
Sbjct: 350 GHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDD--FGRT 407

Query: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 713
            LHAAA  G++E  ++LL  GA+ N  DK  R+PL  A  N + +    +V  G  V   
Sbjct: 408 CLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDL 467

Query: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL-- 771
           +E G T LH+AA           L     +   +D  G+  + ++A + H   ++++   
Sbjct: 468 DERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASE 527

Query: 772 --------TRGAD-VTLTDNEENIC-LHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 821
                   T G D ++ +DN   I  LH A++ G     EVL+ +  DL   N  G TPL
Sbjct: 528 TPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPL 587

Query: 822 HIAARESYHDCVLLFLSRGAN 842
            +AA + + +CV + +++GA+
Sbjct: 588 DLAAFKGHVECVDVLINQGAS 608



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 71/226 (31%), Positives = 106/226 (46%), Gaps = 8/226 (3%)

Query: 633 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 692
           +L    ++D N  +      T LH A   G  E C  LL         +    +PL  AV
Sbjct: 738 LLQSAASMDANPATADNHGYTALHWACYNGH-ETCVELLLEQEVFQKTEGNAFSPLHCAV 796

Query: 693 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 750
           +N++   A  ++   G   V + +  G T LH AA   ++E + LLLS     VN+ DS 
Sbjct: 797 INDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHN-AQVNSVDST 855

Query: 751 GWTPIIWAAEHKHIEVIRMLLTRG-ADVTLTDNEENICLHWASFTGSAAIAEVLLNARCD 809
           G TP++ AAE+     + ML++   A++TL DN +N  LH A   G    A ++L    D
Sbjct: 856 GKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITD 915

Query: 810 ---LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
              ++A N    TPLH+AAR      V   L +GA+    ++ G T
Sbjct: 916 RNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYT 961



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 66/263 (25%), Positives = 112/263 (42%), Gaps = 47/263 (17%)

Query: 647 DQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR 706
           + ++  TPLH AA+ G   + + L+ +GA+          PL  A ++   +  R ++  
Sbjct: 335 EDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSS 394

Query: 707 GGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEV 766
           G  + + ++ G TCLH AA  GNLE ++LLL+TG  D N +D  G +P+ +AA + + + 
Sbjct: 395 GFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTG-ADFNKKDKFGRSPLHYAAANCNYQC 453

Query: 767 IRMLLTRGADVTLTDNEENICLHWA--SFTGSAAIAEVLLNA-------RCDLHAVNYHG 817
           +  L+  GA V   D      LH+A  S T    +  +L N        +   +AV+Y  
Sbjct: 454 LFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSA 513

Query: 818 D-------------------------------------TPLHIAARESYHDCVLLFLSRG 840
                                                 +PLH+AA   +H  + + +   
Sbjct: 514 AYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSL 573

Query: 841 ANPELRNKEGDTAWDLTPERSDV 863
            + ++RN  G T  DL   +  V
Sbjct: 574 LDLDVRNSSGRTPLDLAAFKGHV 596



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 59/203 (29%), Positives = 96/203 (47%), Gaps = 9/203 (4%)

Query: 652 RTPLHAAAQKGSVEICHVLLQAGANINA----VDKQQRTPLMEAVVNNHLEVARYMVQRG 707
           RTP+H +A  G + +   LLQ+ A+++A     D    T L  A  N H      ++++ 
Sbjct: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 779

Query: 708 GCVYSKEEDGSTCLHHAAKIGNLEMVSLLL--STGQVDVNAQDSGGWTPIIWAAEHKHIE 765
             V+ K E  +    H A I + E  + +L  + G   VNA DS G TP+  AA   H+E
Sbjct: 780 --VFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVE 837

Query: 766 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLL-NARCDLHAVNYHGDTPLHIA 824
            +++LL+  A V   D+     L  A+  G     E+L+ +A  +L   +   +T LH+A
Sbjct: 838 CLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLA 897

Query: 825 ARESYHDCVLLFLSRGANPELRN 847
             + +    LL L +  +  L N
Sbjct: 898 CSKGHETSALLILEKITDRNLIN 920



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 47/168 (27%), Positives = 65/168 (38%), Gaps = 39/168 (23%)

Query: 635 MLLDNLDPNFQSDQQSK-RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVV 693
           ML+D L  +  +   SK RTPLHAAA    VE   +LL   A +N+VD   +TPLM A  
Sbjct: 806 MLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAE 865

Query: 694 NNHLEVARYMVQRGGCVYSKEEDGS----------------------------------- 718
           N        +V       + +++                                     
Sbjct: 866 NGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAA 925

Query: 719 --TCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHI 764
             T LH AA+ G   +V  LL  G   V A D  G+TP +  A +K +
Sbjct: 926 LQTPLHVAARNGLTMVVQELLGKG-ASVLAVDENGYTPALACAPNKDV 972



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 37/111 (33%), Positives = 55/111 (49%)

Query: 743 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEV 802
           DVN QD+   TP+  AA     E+I +L+  GA V   D++    LH A  + S    +V
Sbjct: 33  DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQV 92

Query: 803 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
           LL    D++A + +  TPLHIAA      C    +   +N  + ++ G TA
Sbjct: 93  LLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTA 143



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 24/76 (31%), Positives = 38/76 (50%), Gaps = 1/76 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNF-QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 678
           L+L+  +G     +L+L    D N   +   + +TPLH AA+ G   +   LL  GA++ 
Sbjct: 894 LHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVL 953

Query: 679 AVDKQQRTPLMEAVVN 694
           AVD+   TP +    N
Sbjct: 954 AVDENGYTPALACAPN 969



 Score = 37.4 bits (85), Expect = 0.085
 Identities = 33/124 (26%), Positives = 57/124 (45%), Gaps = 5/124 (4%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGAN--- 676
           L ++ + G+   V  ML+ +          SK T LH A  KG      ++L+   +   
Sbjct: 860 LMMAAENGQTNTVE-MLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNL 918

Query: 677 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGST-CLHHAAKIGNLEMVSL 735
           INA +   +TPL  A  N    V + ++ +G  V + +E+G T  L  A      + ++L
Sbjct: 919 INATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLAL 978

Query: 736 LLST 739
           +L+T
Sbjct: 979 ILAT 982


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  120 bits (301), Expect = 8e-27
 Identities = 91/304 (29%), Positives = 146/304 (48%), Gaps = 6/304 (1%)

Query: 584 LSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPN 643
           L+A+ +    G   + K L+ +++    K       L+++ K+  + KV+ +LL +   +
Sbjct: 368 LTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRI-KVMELLLKH-GAS 425

Query: 644 FQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYM 703
            Q+  +S  TP+H AA  G V I   L+  GA+ N  + +  T L  A  +   EV RY+
Sbjct: 426 IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485

Query: 704 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKH 763
           VQ G  V +K +D  T LH +A++G  ++V  LL  G    NA  + G+TP+  +A   H
Sbjct: 486 VQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQG-ASPNAATTSGYTPLHLSAREGH 544

Query: 764 IEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 823
            +V   LL  GA +++T  +    LH A+  G   +A +LL       A    G TPLH+
Sbjct: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604

Query: 824 AARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIR 883
           AA        LL L +GA+P    K G T   +  +++ +  A  L   L  G    A+ 
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL---LEYGADANAVT 661

Query: 884 TEKI 887
            + I
Sbjct: 662 RQGI 665



 Score =  112 bits (279), Expect = 3e-24
 Identities = 78/244 (31%), Positives = 117/244 (47%), Gaps = 3/244 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ + G+ + V  ++ D      ++  +  +TPLH +A+ G  +I   LLQ GA+ NA
Sbjct: 470 LHMAARSGQAEVVRYLVQDGAQ--VEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
                 TPL  +    H +VA +++  G  +    + G T LH AAK G LE+ +LLL  
Sbjct: 528 ATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
                +A    G TP+  AA + + +V  +LL +GA            LH A+      I
Sbjct: 588 S-ASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDI 646

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
           A  LL    D +AV   G   +H+AA+E + D V L L R AN  L NK G T   L  +
Sbjct: 647 ATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQ 706

Query: 860 RSDV 863
              V
Sbjct: 707 EDRV 710



 Score =  105 bits (262), Expect = 3e-22
 Identities = 81/259 (31%), Positives = 119/259 (45%), Gaps = 30/259 (11%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+L+ K+G ++ V  +L    + N  +  +   T LH A+  G  E+  VL+  GAN+NA
Sbjct: 78  LHLASKEGHVEVVSELL--QREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNA 135

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             +   TPL  A   NHLEV ++++  G       EDG T L  A + G+ ++VSLLL  
Sbjct: 136 QSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195

Query: 740 G--------------------------QVDVNA--QDSGGWTPIIWAAEHKHIEVIRMLL 771
                                      Q D NA  +   G+TP+  AA + +I V  +LL
Sbjct: 196 DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLL 255

Query: 772 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 831
            R A V  T   +   LH AS  G+A + ++LL+    + A    G TPLH  AR  +  
Sbjct: 256 NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQ 315

Query: 832 CVLLFLSRGANPELRNKEG 850
            V + L R A    + K G
Sbjct: 316 VVEMLLDRAAPILSKTKNG 334



 Score =  104 bits (259), Expect = 6e-22
 Identities = 70/234 (29%), Positives = 116/234 (49%), Gaps = 3/234 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ K G+L+   L+L  +  P+     +S  TPLH AA   + ++  +LL  GA+ +A
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAG--KSGLTPLHVAAHYDNQKVALLLLDQGASPHA 626

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             K   TPL  A   N +++A  +++ G    +    G   +H AA+ G+++MVSLLL  
Sbjct: 627 AAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 686

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
              +VN  +  G TP+  AA+   + V  +L+ +GA V          LH     G+  I
Sbjct: 687 N-ANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKI 745

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
              LL     ++A   +G TPLH AA++ +   + + L   A+P      G+TA
Sbjct: 746 VNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTA 799



 Score =  103 bits (257), Expect = 1e-21
 Identities = 74/268 (27%), Positives = 130/268 (48%), Gaps = 3/268 (1%)

Query: 585 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 644
           +A+ +    G+  + + LV   ++   K +     L++S + G+   V  +L     PN 
Sbjct: 468 TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527

Query: 645 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV 704
            +   S  TPLH +A++G  ++   LL  GA+++   K+  TPL  A     LEVA  ++
Sbjct: 528 ATT--SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL 585

Query: 705 QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHI 764
           Q+     +  + G T LH AA   N ++  LLL  G    +A    G+TP+  AA+   +
Sbjct: 586 QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG-ASPHAAAKNGYTPLHIAAKKNQM 644

Query: 765 EVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 824
           ++   LL  GAD      +    +H A+  G   +  +LL    +++  N  G TPLH+A
Sbjct: 645 DIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLA 704

Query: 825 ARESYHDCVLLFLSRGANPELRNKEGDT 852
           A+E   +   + +++GA+ + + K G T
Sbjct: 705 AQEDRVNVAEVLVNQGAHVDAQTKMGYT 732



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 81/287 (28%), Positives = 135/287 (47%), Gaps = 33/287 (11%)

Query: 596 EALEKALVIQESERRKKLRFHPRQLYL-SVKQGELQKVILMLLDNLDPNFQSDQQSKRTP 654
           E  EK    ++  R +K +      YL + + G L+K +  + + +D N  +  Q+    
Sbjct: 20  EEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICN--QNGLNA 77

Query: 655 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 714
           LH A+++G VE+   LLQ  AN++A  K+  T L  A +    EV + +V  G  V ++ 
Sbjct: 78  LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137

Query: 715 EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL--- 771
           ++G T L+ AA+  +LE+V  LL  G     A +  G+TP+  A +  H +V+ +LL   
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATED-GFTPLAVALQQGHDQVVSLLLEND 196

Query: 772 TRG-----------------ADVTLTDNEEN---------ICLHWASFTGSAAIAEVLLN 805
           T+G                 A   L  N+ N           LH A+  G+  +A +LLN
Sbjct: 197 TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLN 256

Query: 806 ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
               +     +  TPLH+A++    + V L L RGA  + + ++G T
Sbjct: 257 RAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLT 303



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 72/287 (25%), Positives = 122/287 (42%), Gaps = 39/287 (13%)

Query: 601 ALVIQESER---RKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHA 657
           AL++Q         K  F P  L+++   G +    L+L      +F +  ++  TPLH 
Sbjct: 219 ALLLQNDNNADVESKSGFTP--LHIAAHYGNINVATLLLNRAAAVDFTA--RNDITPLHV 274

Query: 658 AAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDG 717
           A+++G+  +  +LL  GA I+A  +   TPL     + H +V   ++ R   + SK ++G
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG 334

Query: 718 STCLHHAAKIGNLEMVSLLLSTG--------------------------------QVDVN 745
            + LH A +  +L  V LLL                                   + + N
Sbjct: 335 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN 394

Query: 746 AQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLN 805
           A+   G+TP+  A +   I+V+ +LL  GA +          +H A+F G   I   L++
Sbjct: 395 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH 454

Query: 806 ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
                +  N  G+T LH+AAR    + V   +  GA  E + K+  T
Sbjct: 455 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQT 501



 Score = 87.0 bits (214), Expect = 9e-17
 Identities = 61/200 (30%), Positives = 98/200 (49%), Gaps = 2/200 (1%)

Query: 630 QKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLM 689
           QKV L+LLD    +  +  ++  TPLH AA+K  ++I   LL+ GA+ NAV +Q    + 
Sbjct: 611 QKVALLLLDQ-GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVH 669

Query: 690 EAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDS 749
            A    H+++   ++ R   V    + G T LH AA+   + +  +L++ G   V+AQ  
Sbjct: 670 LAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG-AHVDAQTK 728

Query: 750 GGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCD 809
            G+TP+     + +I+++  LL   A V          LH A+  G   I  VLL     
Sbjct: 729 MGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788

Query: 810 LHAVNYHGDTPLHIAARESY 829
            + +  +G+T L IA R  Y
Sbjct: 789 PNELTVNGNTALGIARRLGY 808



 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 54/184 (29%), Positives = 89/184 (48%), Gaps = 3/184 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ K+ ++     +L    D N  + Q      +H AAQ+G V++  +LL   AN+N 
Sbjct: 635 LHIAAKKNQMDIATTLLEYGADANAVTRQGI--ASVHLAAQEGHVDMVSLLLGRNANVNL 692

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            +K   TPL  A   + + VA  +V +G  V ++ + G T LH     GN+++V+ LL  
Sbjct: 693 SNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQH 752

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
               VNA+   G+TP+  AA+  H  +I +LL   A         N  L  A   G  ++
Sbjct: 753 S-AKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISV 811

Query: 800 AEVL 803
            + L
Sbjct: 812 VDTL 815



 Score = 33.9 bits (76), Expect = 0.94
 Identities = 16/45 (35%), Positives = 27/45 (60%)

Query: 809 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
           D++  N +G   LH+A++E + + V   L R AN +   K+G+TA
Sbjct: 66  DINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTA 110



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 19/75 (25%), Positives = 34/75 (45%)

Query: 280  DERVDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGR 339
            ++RVD   K   E LTE      ++ E+  +E +  E++   +  +E  +QS  S S  +
Sbjct: 2574 EDRVDRTVKEAEEKLTEVSQFFRDKTEKLNDELQSPEKKARPKNGKEYSSQSPTSSSPEK 2633

Query: 340  RKAKKKWRKDSPWVK 354
                +    +  WVK
Sbjct: 2634 VLLTELLASNDEWVK 2648


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  120 bits (300), Expect = 1e-26
 Identities = 76/233 (32%), Positives = 119/233 (51%), Gaps = 3/233 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++   G+ + + L++L     N + +     TPLH A    S E   VL++  A++NA
Sbjct: 20  LHVAAFLGDAEIIELLILSGARVNAKDNMWL--TPLHRAVASRSEEAVQVLIKHSADVNA 77

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            DK  +TPL  A  N  ++ A  ++     V   +  G T LHHAA  G++EMV+LLL+ 
Sbjct: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
           G  ++NA D      + WAA   H++V+ +L+  GA+VT  D +    LH A+  G   +
Sbjct: 138 G-ANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINV 196

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
            + LLN   ++  +N +G+T LHIA        V   +  GAN    N  G T
Sbjct: 197 VKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFT 249



 Score =  113 bits (283), Expect = 9e-25
 Identities = 69/206 (33%), Positives = 110/206 (53%), Gaps = 7/206 (3%)

Query: 651 KRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCV 710
           KRTPLH AA  G  EI  +L+ +GA +NA D    TPL  AV +   E  + +++    V
Sbjct: 16  KRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADV 75

Query: 711 YSKEEDGSTCLHHAAK---IGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVI 767
            +++++  T LH AA    +   E++  LLS+    VN  D GG T +  AA + H+E++
Sbjct: 76  NARDKNWQTPLHVAAANKAVKCAEVIIPLLSS----VNVSDRGGRTALHHAALNGHVEMV 131

Query: 768 RMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARE 827
            +LL +GA++   D ++   LHWA++ G   +  +L+N   ++   +  G TPLH AA  
Sbjct: 132 NLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASN 191

Query: 828 SYHDCVLLFLSRGANPELRNKEGDTA 853
              + V   L+ G   +  N  G+TA
Sbjct: 192 GQINVVKHLLNLGVEIDEINVYGNTA 217



 Score =  113 bits (283), Expect = 9e-25
 Identities = 67/239 (28%), Positives = 133/239 (55%), Gaps = 4/239 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+ +V     + V +++  + D N +   ++ +TPLH AA   +V+   V++   +++N 
Sbjct: 53  LHRAVASRSEEAVQVLIKHSADVNARD--KNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            D+  RT L  A +N H+E+   ++ +G  + + ++     LH AA +G+L++V+LL++ 
Sbjct: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
           G  +V  +D  G+TP+  AA +  I V++ LL  G ++   +   N  LH A + G  A+
Sbjct: 171 G-AEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAV 229

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLT 857
              L++   +++  N +G TPLH AA  ++   C+ L ++ GA+  +++K+G +   +T
Sbjct: 230 VNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMT 288



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 74/259 (28%), Positives = 122/259 (47%), Gaps = 37/259 (14%)

Query: 617 PRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGAN 676
           P  +  + K  +  +VI+ LL +++ +     +  RT LH AA  G VE+ ++LL  GAN
Sbjct: 85  PLHVAAANKAVKCAEVIIPLLSSVNVS----DRGGRTALHHAALNGHVEMVNLLLAKGAN 140

Query: 677 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 736
           INA DK+ R  L  A    HL+V   ++  G  V  K++ G T LH AA  G + +V  L
Sbjct: 141 INAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHL 200

Query: 737 LSTG-QVD-------------------------------VNAQDSGGWTPIIWAAEHKHI 764
           L+ G ++D                               VN  ++ G+TP+ +AA   H 
Sbjct: 201 LNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHG 260

Query: 765 EV-IRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 823
            + + +L+  GADV +   +    LH  +  G    ++ L+    ++  V+  G+TPLH+
Sbjct: 261 ALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHV 320

Query: 824 AARESYHDCVLLFLSRGAN 842
           AAR  +   +    + GA+
Sbjct: 321 AARYGHELLINTLRTSGAD 339



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 63/225 (28%), Positives = 108/225 (48%), Gaps = 2/225 (0%)

Query: 630 QKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEIC-HVLLQAGANINAVDKQQRTPL 688
           Q  ++  L +   N      +  TPLH AA      +C  +L+  GA++N   K  ++PL
Sbjct: 226 QDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPL 285

Query: 689 MEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQD 748
               V+     ++ ++Q GG +   ++DG+T LH AA+ G+  +++ L ++G  D     
Sbjct: 286 HMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSG-ADTAKCG 344

Query: 749 SGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 808
                P+  AA + H +  R LL+ G ++   D     CLH A+  G+    ++L ++  
Sbjct: 345 IHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGA 404

Query: 809 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
           D H  +  G TPLH AA   +  C+   ++ GAN    +  G TA
Sbjct: 405 DFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTA 449



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 66/235 (28%), Positives = 96/235 (40%), Gaps = 2/235 (0%)

Query: 618 RQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANI 677
           R L+ +   G L  V L++  N         +   TPLHAAA  G + +   LL  G  I
Sbjct: 150 RALHWAAYMGHLDVVALLI--NHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEI 207

Query: 678 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 737
           + ++    T L  A  N    V   ++  G  V     +G T LH AA   +  +   LL
Sbjct: 208 DEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELL 267

Query: 738 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 797
                DVN Q   G +P+   A H      + L+  G ++   D + N  LH A+  G  
Sbjct: 268 VNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHE 327

Query: 798 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
            +   L  +  D      H   PLH+AA  ++ DC    LS G   +  +K G T
Sbjct: 328 LLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRT 382



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 67/251 (26%), Positives = 114/251 (45%), Gaps = 17/251 (6%)

Query: 596 EALEKALVIQESERRKKLRF----------HPRQLYLSVKQGEL---QKVILMLLDNLDP 642
           E LE+A  ++E E    L F            ++ Y S+        ++ + +LL+  + 
Sbjct: 473 EELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNS 532

Query: 643 NFQ-SDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR 701
            F+ SD  + ++PLH AA  G  +   VLLQ+  +++  D++ RT L  A    H E   
Sbjct: 533 GFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVE 592

Query: 702 YMVQRGGCVYSKEE-DGSTCLHHAAKIGNLEMVSLLLSTGQVD--VNAQDSGGWTPIIWA 758
            ++  G  ++ K+     T LH +   G+   + LLL        V+ +D+ G TP++ A
Sbjct: 593 ALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLA 652

Query: 759 AEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGD 818
             + HI+ + +LL + A+V   D      LH    TG     ++LL     +   +  G 
Sbjct: 653 VAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGR 712

Query: 819 TPLHIAARESY 829
           TPLH AA   +
Sbjct: 713 TPLHYAAARGH 723



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 72/270 (26%), Positives = 111/270 (41%), Gaps = 41/270 (15%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L L+V  G +  V L+L    + N  +      T LH     G  E   +LL+   +I  
Sbjct: 649 LMLAVAYGHIDAVSLLL--EKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILC 706

Query: 680 VDKQQRTPLMEAVVNNHL----EVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSL 735
            D + RTPL  A    H     E+ +  +    C + K+  G T LH A   GN   + +
Sbjct: 707 KDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCF-KDNQGYTPLHWACYNGNENCIEV 765

Query: 736 LLST------------------------------GQVD---VNAQDSGGWTPIIWAAEHK 762
           LL                                G +D   V+ +D  G TP+  AA   
Sbjct: 766 LLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFAD 825

Query: 763 HIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLN-ARCDLHAVNYHGDTPL 821
           H+E +++LL   A V   DN     L  A+  G A   ++L+N A+ DL   +   +TPL
Sbjct: 826 HVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPL 885

Query: 822 HIAARESYHDCVLLFLSRGANPELRNKEGD 851
           H+A  + +  C LL L +  +  L N++ +
Sbjct: 886 HLACSKGHEKCALLILDKIQDESLINEKNN 915



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 69/224 (30%), Positives = 104/224 (46%), Gaps = 16/224 (7%)

Query: 640 LDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHL 697
           L   F+ D   K  RT LHAAA  G+VE   +L  +GA+ +  DK  RTPL  A  N H 
Sbjct: 367 LSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHF 426

Query: 698 EVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 757
                +V  G  V   ++ G T LH+AA   +++    +L       NA D+     +  
Sbjct: 427 HCIETLVTTGANVNETDDWGRTALHYAA-ASDMDRNKTILG------NAHDNS--EELER 477

Query: 758 AAEHKHIEV---IRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 814
           A E K  E    +  LL   A+ ++ D E    +H+A+  G     E+LL         +
Sbjct: 478 ARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEES 537

Query: 815 YHGDT--PLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDL 856
             G T  PLH+AA   +H  + + L    + ++R+++G TA DL
Sbjct: 538 DSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDL 581



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 64/252 (25%), Positives = 103/252 (40%), Gaps = 33/252 (13%)

Query: 634 LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVV 693
           + LL +   +F    +  RTPLH AA          L+  GAN+N  D   RT L  A  
Sbjct: 396 IKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAA 455

Query: 694 NN----------------HLEVAR------------YMVQRGGCVYSKEEDGSTCLHHAA 725
           ++                 LE AR            +++Q       ++++G   +H+AA
Sbjct: 456 SDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAA 515

Query: 726 KIGNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLLTRGADVTLTDNEE 784
             G+ + + LLL          DSG   +P+  AA + H + + +LL    D+ + D + 
Sbjct: 516 AYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKG 575

Query: 785 NICLHWASFTGSAAIAEVLLNARCDLHAV-NYHGDTPLHIAARESYHDCVLLFLSRGANP 843
              L  A+F G     E L+N    +    N    TPLH +    +  C+ L L    NP
Sbjct: 576 RTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNP 635

Query: 844 E---LRNKEGDT 852
           E   +++ +G T
Sbjct: 636 EAVDVKDAKGQT 647



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 64/234 (27%), Positives = 106/234 (45%), Gaps = 8/234 (3%)

Query: 631 KVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLME 690
           +++L + DN +     D + + TPL  A   G ++   +LL+  AN++ VD    T L  
Sbjct: 626 RLLLEIADNPEAVDVKDAKGQ-TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHR 684

Query: 691 AVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL--STGQVDVNAQD 748
            ++  H E  + ++++   +  K+  G T LH+AA  G+   +S LL  +  + D   +D
Sbjct: 685 GIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKD 744

Query: 749 SGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 808
           + G+TP+ WA  + +   I +LL +        N     LH A        A +LL A  
Sbjct: 745 NQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFT-PLHCAIINDHGNCASLLLGA-I 802

Query: 809 DLHAVNYHGD---TPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
           D   V+   D   TPL  AA   + +C+ L L   A     +  G TA  +  E
Sbjct: 803 DSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAE 856



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 35/111 (31%), Positives = 54/111 (48%)

Query: 743 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEV 802
           DVN  DS   TP+  AA     E+I +L+  GA V   DN     LH A  + S    +V
Sbjct: 8   DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67

Query: 803 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
           L+    D++A + +  TPLH+AA      C  + +   ++  + ++ G TA
Sbjct: 68  LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTA 118



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 26/84 (30%), Positives = 42/84 (50%)

Query: 769 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARES 828
           ML+ +  DV   D+E+   LH A+F G A I E+L+ +   ++A +    TPLH A    
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 829 YHDCVLLFLSRGANPELRNKEGDT 852
             + V + +   A+   R+K   T
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQT 84


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  117 bits (293), Expect = 6e-26
 Identities = 85/259 (32%), Positives = 133/259 (51%), Gaps = 9/259 (3%)

Query: 598 LEKALVIQESERRK----KLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 653
           +E  L + E E  +    K  F P  L+++ K G+++   L+L  +  PN     ++  T
Sbjct: 549 VETVLALLEKEASQACMTKKGFTP--LHVAAKYGKVRVAELLLERDAHPNAAG--KNGLT 604

Query: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 713
           PLH A    +++I  +LL  G + ++      TPL  A   N +EVAR ++Q GG   ++
Sbjct: 605 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 664

Query: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
              G T LH AA+ G+ EMV+LLLS  Q + N  +  G TP+   A+  H+ V  +L+  
Sbjct: 665 SVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723

Query: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 833
           G  V  T       LH AS  G+  + + LL  + D++A    G +PLH AA++ + D V
Sbjct: 724 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 783

Query: 834 LLFLSRGANPELRNKEGDT 852
            L L  GA+P   + +G T
Sbjct: 784 TLLLKNGASPNEVSSDGTT 802



 Score =  115 bits (288), Expect = 2e-25
 Identities = 81/250 (32%), Positives = 123/250 (49%), Gaps = 3/250 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ K+  ++  ++ LL     +  +  +S  TPLH A+  G + I   LLQ GA+ N 
Sbjct: 408 LHIACKKNHVR--VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 465

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            + +  TPL  A    H EVA+Y++Q    V +K +D  T LH AA+IG+  MV LLL  
Sbjct: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE- 524

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
              + N   + G TP+  AA   H+E +  LL + A       +    LH A+  G   +
Sbjct: 525 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 584

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
           AE+LL      +A   +G TPLH+A   +  D V L L RG +P      G T   +  +
Sbjct: 585 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 644

Query: 860 RSDVWFALQL 869
           ++ V  A  L
Sbjct: 645 QNQVEVARSL 654



 Score =  108 bits (271), Expect = 2e-23
 Identities = 79/279 (28%), Positives = 135/279 (48%), Gaps = 3/279 (1%)

Query: 594 GREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 653
           G   + + L+ + ++   K +     L+ + + G + ++  +LLD+  P  Q+  ++  +
Sbjct: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHV-RISEILLDHGAP-IQAKTKNGLS 340

Query: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 713
           P+H AAQ   ++   +LLQ  A I+ +     TPL  A    H  VA+ ++ +G    S+
Sbjct: 341 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 400

Query: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
             +G T LH A K  ++ ++ LLL TG   ++A    G TP+  A+   H+ +++ LL R
Sbjct: 401 ALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 459

Query: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 833
           GA   +++ +    LH A+  G   +A+ LL  +  ++A      TPLH AAR  + + V
Sbjct: 460 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 519

Query: 834 LLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRK 872
            L L   ANP L    G T   +      V   L L  K
Sbjct: 520 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 558



 Score =  104 bits (259), Expect = 6e-22
 Identities = 75/246 (30%), Positives = 114/246 (46%), Gaps = 7/246 (2%)

Query: 620 LYLSVKQG--ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANI 677
           L+++ + G  E+ K +L     ++   + DQ    TPLH AA+ G   +  +LL+  AN 
Sbjct: 474 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ----TPLHCAARIGHTNMVKLLLENNANP 529

Query: 678 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 737
           N       TPL  A    H+E    ++++        + G T LH AAK G + +  LLL
Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 589

Query: 738 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 797
                  NA    G TP+  A  H +++++++LL RG             LH A+     
Sbjct: 590 ER-DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 648

Query: 798 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLT 857
            +A  LL      +A +  G TPLH+AA+E + + V L LS+ AN  L NK G T   L 
Sbjct: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 708

Query: 858 PERSDV 863
            +   V
Sbjct: 709 AQEGHV 714



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 30/259 (11%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+L+ K+G ++ V+ +L   +    ++  +   T LH AA  G  E+   L+  GAN+NA
Sbjct: 82  LHLASKEGHVKMVVELLHKEII--LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 139

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             ++  TPL  A   NHLEV +++++ G       EDG T L  A + G+  +V+ L++ 
Sbjct: 140 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 199

Query: 740 G--------------------------QVDVNAQ--DSGGWTPIIWAAEHKHIEVIRMLL 771
           G                          Q D N       G+TP+  AA ++++ V ++LL
Sbjct: 200 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 259

Query: 772 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 831
            RGA V  T       LH AS  G+  +  +LL+    +        TPLH AAR  +  
Sbjct: 260 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 319

Query: 832 CVLLFLSRGANPELRNKEG 850
              + L  GA  + + K G
Sbjct: 320 ISEILLDHGAPIQAKTKNG 338



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 59/184 (32%), Positives = 94/184 (51%), Gaps = 3/184 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ KQ +++    +L      N +S Q    TPLH AAQ+G  E+  +LL   AN N 
Sbjct: 639 LHIAAKQNQVEVARSLLQYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNL 696

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            +K   TPL       H+ VA  +++ G  V +    G T LH A+  GN+++V  LL  
Sbjct: 697 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 756

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
            Q DVNA+   G++P+  AA+  H +++ +LL  GA      ++    L  A   G  ++
Sbjct: 757 -QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 815

Query: 800 AEVL 803
            +VL
Sbjct: 816 TDVL 819



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 76/277 (27%), Positives = 125/277 (45%), Gaps = 17/277 (6%)

Query: 596 EALEKALVIQESERRKKLRFHPRQ--------LYLSVKQGELQKVILMLLDNLDPNFQSD 647
           +AL++    +ES R+++ R   R+           + + G L K +  L + +D N  + 
Sbjct: 17  QALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDIN--TC 74

Query: 648 QQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRG 707
            Q+    LH A+++G V++   LL     +    K+  T L  A +    EV R +V  G
Sbjct: 75  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134

Query: 708 GCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVI 767
             V ++ + G T L+ AA+  +LE+V  LL  G  + N     G+TP+  A +  H  V+
Sbjct: 135 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG-ANQNVATEDGFTPLAVALQQGHENVV 193

Query: 768 RMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAAR 826
             L+  G     T  +  +  LH A+       A VLL    +   ++  G TPLHIAA 
Sbjct: 194 AHLINYG-----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 248

Query: 827 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDV 863
               +   L L+RGA+     + G T   +   R +V
Sbjct: 249 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 285


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  117 bits (293), Expect = 6e-26
 Identities = 85/259 (32%), Positives = 133/259 (51%), Gaps = 9/259 (3%)

Query: 598 LEKALVIQESERRK----KLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 653
           +E  L + E E  +    K  F P  L+++ K G+++   L+L  +  PN     ++  T
Sbjct: 516 VETVLALLEKEASQACMTKKGFTP--LHVAAKYGKVRVAELLLERDAHPNAAG--KNGLT 571

Query: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 713
           PLH A    +++I  +LL  G + ++      TPL  A   N +EVAR ++Q GG   ++
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631

Query: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
              G T LH AA+ G+ EMV+LLLS  Q + N  +  G TP+   A+  H+ V  +L+  
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690

Query: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 833
           G  V  T       LH AS  G+  + + LL  + D++A    G +PLH AA++ + D V
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750

Query: 834 LLFLSRGANPELRNKEGDT 852
            L L  GA+P   + +G T
Sbjct: 751 TLLLKNGASPNEVSSDGTT 769



 Score =  115 bits (288), Expect = 2e-25
 Identities = 81/250 (32%), Positives = 123/250 (49%), Gaps = 3/250 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ K+  ++  ++ LL     +  +  +S  TPLH A+  G + I   LLQ GA+ N 
Sbjct: 375 LHIACKKNHVR--VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            + +  TPL  A    H EVA+Y++Q    V +K +D  T LH AA+IG+  MV LLL  
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE- 491

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
              + N   + G TP+  AA   H+E +  LL + A       +    LH A+  G   +
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
           AE+LL      +A   +G TPLH+A   +  D V L L RG +P      G T   +  +
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611

Query: 860 RSDVWFALQL 869
           ++ V  A  L
Sbjct: 612 QNQVEVARSL 621



 Score =  108 bits (271), Expect = 2e-23
 Identities = 79/279 (28%), Positives = 135/279 (48%), Gaps = 3/279 (1%)

Query: 594 GREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 653
           G   + + L+ + ++   K +     L+ + + G + ++  +LLD+  P  Q+  ++  +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHV-RISEILLDHGAP-IQAKTKNGLS 307

Query: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 713
           P+H AAQ   ++   +LLQ  A I+ +     TPL  A    H  VA+ ++ +G    S+
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367

Query: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
             +G T LH A K  ++ ++ LLL TG   ++A    G TP+  A+   H+ +++ LL R
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 426

Query: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 833
           GA   +++ +    LH A+  G   +A+ LL  +  ++A      TPLH AAR  + + V
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486

Query: 834 LLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRK 872
            L L   ANP L    G T   +      V   L L  K
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525



 Score =  104 bits (259), Expect = 6e-22
 Identities = 75/246 (30%), Positives = 114/246 (46%), Gaps = 7/246 (2%)

Query: 620 LYLSVKQG--ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANI 677
           L+++ + G  E+ K +L     ++   + DQ    TPLH AA+ G   +  +LL+  AN 
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ----TPLHCAARIGHTNMVKLLLENNANP 496

Query: 678 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 737
           N       TPL  A    H+E    ++++        + G T LH AAK G + +  LLL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556

Query: 738 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 797
                  NA    G TP+  A  H +++++++LL RG             LH A+     
Sbjct: 557 ER-DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 798 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLT 857
            +A  LL      +A +  G TPLH+AA+E + + V L LS+ AN  L NK G T   L 
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 858 PERSDV 863
            +   V
Sbjct: 676 AQEGHV 681



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 30/259 (11%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+L+ K+G ++ V+ +L   +    ++  +   T LH AA  G  E+   L+  GAN+NA
Sbjct: 49  LHLASKEGHVKMVVELLHKEII--LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 106

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             ++  TPL  A   NHLEV +++++ G       EDG T L  A + G+  +V+ L++ 
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166

Query: 740 G--------------------------QVDVNAQ--DSGGWTPIIWAAEHKHIEVIRMLL 771
           G                          Q D N       G+TP+  AA ++++ V ++LL
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226

Query: 772 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 831
            RGA V  T       LH AS  G+  +  +LL+    +        TPLH AAR  +  
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286

Query: 832 CVLLFLSRGANPELRNKEG 850
              + L  GA  + + K G
Sbjct: 287 ISEILLDHGAPIQAKTKNG 305



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 59/184 (32%), Positives = 94/184 (51%), Gaps = 3/184 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ KQ +++    +L      N +S Q    TPLH AAQ+G  E+  +LL   AN N 
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            +K   TPL       H+ VA  +++ G  V +    G T LH A+  GN+++V  LL  
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
            Q DVNA+   G++P+  AA+  H +++ +LL  GA      ++    L  A   G  ++
Sbjct: 724 -QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782

Query: 800 AEVL 803
            +VL
Sbjct: 783 TDVL 786



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 9/242 (3%)

Query: 623 SVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDK 682
           + + G L K +  L + +D N  +  Q+    LH A+++G V++   LL     +    K
Sbjct: 19  AARSGNLDKALDHLRNGVDIN--TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76

Query: 683 QQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV 742
           +  T L  A +    EV R +V  G  V ++ + G T L+ AA+  +LE+V  LL  G  
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG-A 135

Query: 743 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAE 801
           + N     G+TP+  A +  H  V+  L+  G     T  +  +  LH A+       A 
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYG-----TKGKVRLPALHIAARNDDTRTAA 190

Query: 802 VLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERS 861
           VLL    +   ++  G TPLHIAA     +   L L+RGA+     + G T   +   R 
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 862 DV 863
           +V
Sbjct: 251 NV 252



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 41/140 (29%), Positives = 73/140 (52%), Gaps = 1/140 (0%)

Query: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
           +E D +T    AA+ GNL+     L  G VD+N  +  G   +  A++  H++++  LL 
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNG-VDINTCNQNGLNGLHLASKEGHVKMVVELLH 66

Query: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 832
           +   +  T  + N  LH A+  G   +   L+N   +++A +  G TPL++AA+E++ + 
Sbjct: 67  KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126

Query: 833 VLLFLSRGANPELRNKEGDT 852
           V   L  GAN  +  ++G T
Sbjct: 127 VKFLLENGANQNVATEDGFT 146



 Score = 38.9 bits (89), Expect = 0.029
 Identities = 38/165 (23%), Positives = 70/165 (42%), Gaps = 7/165 (4%)

Query: 744 VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVL 803
           V  +++   T  + AA   +++     L  G D+   +      LH AS  G   +   L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 804 LNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDV 863
           L+    L      G+T LHIAA     + V   ++ GAN   ++++G T   +  + +  
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH- 123

Query: 864 WFALQLNRKLRLGVGNRAIRTE---KIICRDVARGYENVPIPCVN 905
              L++ + L     N+ + TE     +   + +G+ENV    +N
Sbjct: 124 ---LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN 165


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  117 bits (293), Expect = 6e-26
 Identities = 85/259 (32%), Positives = 133/259 (51%), Gaps = 9/259 (3%)

Query: 598 LEKALVIQESERRK----KLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 653
           +E  L + E E  +    K  F P  L+++ K G+++   L+L  +  PN     ++  T
Sbjct: 516 VETVLALLEKEASQACMTKKGFTP--LHVAAKYGKVRVAELLLERDAHPNAAG--KNGLT 571

Query: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 713
           PLH A    +++I  +LL  G + ++      TPL  A   N +EVAR ++Q GG   ++
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631

Query: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
              G T LH AA+ G+ EMV+LLLS  Q + N  +  G TP+   A+  H+ V  +L+  
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690

Query: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 833
           G  V  T       LH AS  G+  + + LL  + D++A    G +PLH AA++ + D V
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750

Query: 834 LLFLSRGANPELRNKEGDT 852
            L L  GA+P   + +G T
Sbjct: 751 TLLLKNGASPNEVSSDGTT 769



 Score =  115 bits (288), Expect = 2e-25
 Identities = 81/250 (32%), Positives = 123/250 (49%), Gaps = 3/250 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ K+  ++  ++ LL     +  +  +S  TPLH A+  G + I   LLQ GA+ N 
Sbjct: 375 LHIACKKNHVR--VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            + +  TPL  A    H EVA+Y++Q    V +K +D  T LH AA+IG+  MV LLL  
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE- 491

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
              + N   + G TP+  AA   H+E +  LL + A       +    LH A+  G   +
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
           AE+LL      +A   +G TPLH+A   +  D V L L RG +P      G T   +  +
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611

Query: 860 RSDVWFALQL 869
           ++ V  A  L
Sbjct: 612 QNQVEVARSL 621



 Score =  108 bits (271), Expect = 2e-23
 Identities = 79/279 (28%), Positives = 135/279 (48%), Gaps = 3/279 (1%)

Query: 594 GREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 653
           G   + + L+ + ++   K +     L+ + + G + ++  +LLD+  P  Q+  ++  +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHV-RISEILLDHGAP-IQAKTKNGLS 307

Query: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 713
           P+H AAQ   ++   +LLQ  A I+ +     TPL  A    H  VA+ ++ +G    S+
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367

Query: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
             +G T LH A K  ++ ++ LLL TG   ++A    G TP+  A+   H+ +++ LL R
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 426

Query: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 833
           GA   +++ +    LH A+  G   +A+ LL  +  ++A      TPLH AAR  + + V
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486

Query: 834 LLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRK 872
            L L   ANP L    G T   +      V   L L  K
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525



 Score =  104 bits (259), Expect = 6e-22
 Identities = 75/246 (30%), Positives = 114/246 (46%), Gaps = 7/246 (2%)

Query: 620 LYLSVKQG--ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANI 677
           L+++ + G  E+ K +L     ++   + DQ    TPLH AA+ G   +  +LL+  AN 
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ----TPLHCAARIGHTNMVKLLLENNANP 496

Query: 678 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 737
           N       TPL  A    H+E    ++++        + G T LH AAK G + +  LLL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556

Query: 738 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 797
                  NA    G TP+  A  H +++++++LL RG             LH A+     
Sbjct: 557 ER-DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 798 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLT 857
            +A  LL      +A +  G TPLH+AA+E + + V L LS+ AN  L NK G T   L 
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 858 PERSDV 863
            +   V
Sbjct: 676 AQEGHV 681



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 30/259 (11%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+L+ K+G ++ V+ +L   +    ++  +   T LH AA  G  E+   L+  GAN+NA
Sbjct: 49  LHLASKEGHVKMVVELLHKEII--LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 106

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             ++  TPL  A   NHLEV +++++ G       EDG T L  A + G+  +V+ L++ 
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166

Query: 740 G--------------------------QVDVNAQ--DSGGWTPIIWAAEHKHIEVIRMLL 771
           G                          Q D N       G+TP+  AA ++++ V ++LL
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226

Query: 772 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 831
            RGA V  T       LH AS  G+  +  +LL+    +        TPLH AAR  +  
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286

Query: 832 CVLLFLSRGANPELRNKEG 850
              + L  GA  + + K G
Sbjct: 287 ISEILLDHGAPIQAKTKNG 305



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 59/184 (32%), Positives = 94/184 (51%), Gaps = 3/184 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ KQ +++    +L      N +S Q    TPLH AAQ+G  E+  +LL   AN N 
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            +K   TPL       H+ VA  +++ G  V +    G T LH A+  GN+++V  LL  
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
            Q DVNA+   G++P+  AA+  H +++ +LL  GA      ++    L  A   G  ++
Sbjct: 724 -QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782

Query: 800 AEVL 803
            +VL
Sbjct: 783 TDVL 786



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 9/242 (3%)

Query: 623 SVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDK 682
           + + G L K +  L + +D N  +  Q+    LH A+++G V++   LL     +    K
Sbjct: 19  AARSGNLDKALDHLRNGVDIN--TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76

Query: 683 QQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV 742
           +  T L  A +    EV R +V  G  V ++ + G T L+ AA+  +LE+V  LL  G  
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG-A 135

Query: 743 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAE 801
           + N     G+TP+  A +  H  V+  L+  G     T  +  +  LH A+       A 
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYG-----TKGKVRLPALHIAARNDDTRTAA 190

Query: 802 VLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERS 861
           VLL    +   ++  G TPLHIAA     +   L L+RGA+     + G T   +   R 
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 862 DV 863
           +V
Sbjct: 251 NV 252



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 41/140 (29%), Positives = 73/140 (52%), Gaps = 1/140 (0%)

Query: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
           +E D +T    AA+ GNL+     L  G VD+N  +  G   +  A++  H++++  LL 
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNG-VDINTCNQNGLNGLHLASKEGHVKMVVELLH 66

Query: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 832
           +   +  T  + N  LH A+  G   +   L+N   +++A +  G TPL++AA+E++ + 
Sbjct: 67  KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126

Query: 833 VLLFLSRGANPELRNKEGDT 852
           V   L  GAN  +  ++G T
Sbjct: 127 VKFLLENGANQNVATEDGFT 146



 Score = 38.9 bits (89), Expect = 0.029
 Identities = 38/165 (23%), Positives = 70/165 (42%), Gaps = 7/165 (4%)

Query: 744 VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVL 803
           V  +++   T  + AA   +++     L  G D+   +      LH AS  G   +   L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 804 LNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDV 863
           L+    L      G+T LHIAA     + V   ++ GAN   ++++G T   +  + +  
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH- 123

Query: 864 WFALQLNRKLRLGVGNRAIRTE---KIICRDVARGYENVPIPCVN 905
              L++ + L     N+ + TE     +   + +G+ENV    +N
Sbjct: 124 ---LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN 165


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  117 bits (293), Expect = 6e-26
 Identities = 85/259 (32%), Positives = 133/259 (51%), Gaps = 9/259 (3%)

Query: 598 LEKALVIQESERRK----KLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 653
           +E  L + E E  +    K  F P  L+++ K G+++   L+L  +  PN     ++  T
Sbjct: 516 VETVLALLEKEASQACMTKKGFTP--LHVAAKYGKVRVAELLLERDAHPNAAG--KNGLT 571

Query: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 713
           PLH A    +++I  +LL  G + ++      TPL  A   N +EVAR ++Q GG   ++
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631

Query: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
              G T LH AA+ G+ EMV+LLLS  Q + N  +  G TP+   A+  H+ V  +L+  
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690

Query: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 833
           G  V  T       LH AS  G+  + + LL  + D++A    G +PLH AA++ + D V
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750

Query: 834 LLFLSRGANPELRNKEGDT 852
            L L  GA+P   + +G T
Sbjct: 751 TLLLKNGASPNEVSSDGTT 769



 Score =  115 bits (288), Expect = 2e-25
 Identities = 81/250 (32%), Positives = 123/250 (49%), Gaps = 3/250 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ K+  ++  ++ LL     +  +  +S  TPLH A+  G + I   LLQ GA+ N 
Sbjct: 375 LHIACKKNHVR--VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            + +  TPL  A    H EVA+Y++Q    V +K +D  T LH AA+IG+  MV LLL  
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE- 491

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
              + N   + G TP+  AA   H+E +  LL + A       +    LH A+  G   +
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
           AE+LL      +A   +G TPLH+A   +  D V L L RG +P      G T   +  +
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611

Query: 860 RSDVWFALQL 869
           ++ V  A  L
Sbjct: 612 QNQVEVARSL 621



 Score =  108 bits (271), Expect = 2e-23
 Identities = 79/279 (28%), Positives = 135/279 (48%), Gaps = 3/279 (1%)

Query: 594 GREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 653
           G   + + L+ + ++   K +     L+ + + G + ++  +LLD+  P  Q+  ++  +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHV-RISEILLDHGAP-IQAKTKNGLS 307

Query: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 713
           P+H AAQ   ++   +LLQ  A I+ +     TPL  A    H  VA+ ++ +G    S+
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367

Query: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
             +G T LH A K  ++ ++ LLL TG   ++A    G TP+  A+   H+ +++ LL R
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 426

Query: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 833
           GA   +++ +    LH A+  G   +A+ LL  +  ++A      TPLH AAR  + + V
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486

Query: 834 LLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRK 872
            L L   ANP L    G T   +      V   L L  K
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525



 Score =  104 bits (259), Expect = 6e-22
 Identities = 75/246 (30%), Positives = 114/246 (46%), Gaps = 7/246 (2%)

Query: 620 LYLSVKQG--ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANI 677
           L+++ + G  E+ K +L     ++   + DQ    TPLH AA+ G   +  +LL+  AN 
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ----TPLHCAARIGHTNMVKLLLENNANP 496

Query: 678 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 737
           N       TPL  A    H+E    ++++        + G T LH AAK G + +  LLL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556

Query: 738 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 797
                  NA    G TP+  A  H +++++++LL RG             LH A+     
Sbjct: 557 ER-DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 798 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLT 857
            +A  LL      +A +  G TPLH+AA+E + + V L LS+ AN  L NK G T   L 
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 858 PERSDV 863
            +   V
Sbjct: 676 AQEGHV 681



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 30/259 (11%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+L+ K+G ++ V+ +L   +    ++  +   T LH AA  G  E+   L+  GAN+NA
Sbjct: 49  LHLASKEGHVKMVVELLHKEII--LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 106

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             ++  TPL  A   NHLEV +++++ G       EDG T L  A + G+  +V+ L++ 
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166

Query: 740 G--------------------------QVDVNAQ--DSGGWTPIIWAAEHKHIEVIRMLL 771
           G                          Q D N       G+TP+  AA ++++ V ++LL
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226

Query: 772 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 831
            RGA V  T       LH AS  G+  +  +LL+    +        TPLH AAR  +  
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286

Query: 832 CVLLFLSRGANPELRNKEG 850
              + L  GA  + + K G
Sbjct: 287 ISEILLDHGAPIQAKTKNG 305



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 59/184 (32%), Positives = 94/184 (51%), Gaps = 3/184 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ KQ +++    +L      N +S Q    TPLH AAQ+G  E+  +LL   AN N 
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            +K   TPL       H+ VA  +++ G  V +    G T LH A+  GN+++V  LL  
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
            Q DVNA+   G++P+  AA+  H +++ +LL  GA      ++    L  A   G  ++
Sbjct: 724 -QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782

Query: 800 AEVL 803
            +VL
Sbjct: 783 TDVL 786



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 9/242 (3%)

Query: 623 SVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDK 682
           + + G L K +  L + +D N  +  Q+    LH A+++G V++   LL     +    K
Sbjct: 19  AARSGNLDKALDHLRNGVDIN--TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76

Query: 683 QQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV 742
           +  T L  A +    EV R +V  G  V ++ + G T L+ AA+  +LE+V  LL  G  
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG-A 135

Query: 743 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAE 801
           + N     G+TP+  A +  H  V+  L+  G     T  +  +  LH A+       A 
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYG-----TKGKVRLPALHIAARNDDTRTAA 190

Query: 802 VLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERS 861
           VLL    +   ++  G TPLHIAA     +   L L+RGA+     + G T   +   R 
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 862 DV 863
           +V
Sbjct: 251 NV 252



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 41/140 (29%), Positives = 73/140 (52%), Gaps = 1/140 (0%)

Query: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
           +E D +T    AA+ GNL+     L  G VD+N  +  G   +  A++  H++++  LL 
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNG-VDINTCNQNGLNGLHLASKEGHVKMVVELLH 66

Query: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 832
           +   +  T  + N  LH A+  G   +   L+N   +++A +  G TPL++AA+E++ + 
Sbjct: 67  KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126

Query: 833 VLLFLSRGANPELRNKEGDT 852
           V   L  GAN  +  ++G T
Sbjct: 127 VKFLLENGANQNVATEDGFT 146



 Score = 38.9 bits (89), Expect = 0.029
 Identities = 38/165 (23%), Positives = 70/165 (42%), Gaps = 7/165 (4%)

Query: 744 VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVL 803
           V  +++   T  + AA   +++     L  G D+   +      LH AS  G   +   L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 804 LNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDV 863
           L+    L      G+T LHIAA     + V   ++ GAN   ++++G T   +  + +  
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH- 123

Query: 864 WFALQLNRKLRLGVGNRAIRTE---KIICRDVARGYENVPIPCVN 905
              L++ + L     N+ + TE     +   + +G+ENV    +N
Sbjct: 124 ---LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN 165


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  117 bits (293), Expect = 6e-26
 Identities = 85/259 (32%), Positives = 133/259 (51%), Gaps = 9/259 (3%)

Query: 598 LEKALVIQESERRK----KLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 653
           +E  L + E E  +    K  F P  L+++ K G+++   L+L  +  PN     ++  T
Sbjct: 516 VETVLALLEKEASQACMTKKGFTP--LHVAAKYGKVRVAELLLERDAHPNAAG--KNGLT 571

Query: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 713
           PLH A    +++I  +LL  G + ++      TPL  A   N +EVAR ++Q GG   ++
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631

Query: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
              G T LH AA+ G+ EMV+LLLS  Q + N  +  G TP+   A+  H+ V  +L+  
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690

Query: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 833
           G  V  T       LH AS  G+  + + LL  + D++A    G +PLH AA++ + D V
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750

Query: 834 LLFLSRGANPELRNKEGDT 852
            L L  GA+P   + +G T
Sbjct: 751 TLLLKNGASPNEVSSDGTT 769



 Score =  115 bits (288), Expect = 2e-25
 Identities = 81/250 (32%), Positives = 123/250 (49%), Gaps = 3/250 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ K+  ++  ++ LL     +  +  +S  TPLH A+  G + I   LLQ GA+ N 
Sbjct: 375 LHIACKKNHVR--VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            + +  TPL  A    H EVA+Y++Q    V +K +D  T LH AA+IG+  MV LLL  
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE- 491

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
              + N   + G TP+  AA   H+E +  LL + A       +    LH A+  G   +
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
           AE+LL      +A   +G TPLH+A   +  D V L L RG +P      G T   +  +
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611

Query: 860 RSDVWFALQL 869
           ++ V  A  L
Sbjct: 612 QNQVEVARSL 621



 Score =  108 bits (271), Expect = 2e-23
 Identities = 79/279 (28%), Positives = 135/279 (48%), Gaps = 3/279 (1%)

Query: 594 GREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 653
           G   + + L+ + ++   K +     L+ + + G + ++  +LLD+  P  Q+  ++  +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHV-RISEILLDHGAP-IQAKTKNGLS 307

Query: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 713
           P+H AAQ   ++   +LLQ  A I+ +     TPL  A    H  VA+ ++ +G    S+
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367

Query: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
             +G T LH A K  ++ ++ LLL TG   ++A    G TP+  A+   H+ +++ LL R
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 426

Query: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 833
           GA   +++ +    LH A+  G   +A+ LL  +  ++A      TPLH AAR  + + V
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486

Query: 834 LLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRK 872
            L L   ANP L    G T   +      V   L L  K
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525



 Score =  104 bits (259), Expect = 6e-22
 Identities = 75/246 (30%), Positives = 114/246 (46%), Gaps = 7/246 (2%)

Query: 620 LYLSVKQG--ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANI 677
           L+++ + G  E+ K +L     ++   + DQ    TPLH AA+ G   +  +LL+  AN 
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ----TPLHCAARIGHTNMVKLLLENNANP 496

Query: 678 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 737
           N       TPL  A    H+E    ++++        + G T LH AAK G + +  LLL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556

Query: 738 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 797
                  NA    G TP+  A  H +++++++LL RG             LH A+     
Sbjct: 557 ER-DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 798 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLT 857
            +A  LL      +A +  G TPLH+AA+E + + V L LS+ AN  L NK G T   L 
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 858 PERSDV 863
            +   V
Sbjct: 676 AQEGHV 681



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 30/259 (11%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+L+ K+G ++ V+ +L   +    ++  +   T LH AA  G  E+   L+  GAN+NA
Sbjct: 49  LHLASKEGHVKMVVELLHKEII--LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 106

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             ++  TPL  A   NHLEV +++++ G       EDG T L  A + G+  +V+ L++ 
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166

Query: 740 G--------------------------QVDVNAQ--DSGGWTPIIWAAEHKHIEVIRMLL 771
           G                          Q D N       G+TP+  AA ++++ V ++LL
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226

Query: 772 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 831
            RGA V  T       LH AS  G+  +  +LL+    +        TPLH AAR  +  
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286

Query: 832 CVLLFLSRGANPELRNKEG 850
              + L  GA  + + K G
Sbjct: 287 ISEILLDHGAPIQAKTKNG 305



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 59/184 (32%), Positives = 94/184 (51%), Gaps = 3/184 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ KQ +++    +L      N +S Q    TPLH AAQ+G  E+  +LL   AN N 
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            +K   TPL       H+ VA  +++ G  V +    G T LH A+  GN+++V  LL  
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
            Q DVNA+   G++P+  AA+  H +++ +LL  GA      ++    L  A   G  ++
Sbjct: 724 -QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782

Query: 800 AEVL 803
            +VL
Sbjct: 783 TDVL 786



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 9/242 (3%)

Query: 623 SVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDK 682
           + + G L K +  L + +D N  +  Q+    LH A+++G V++   LL     +    K
Sbjct: 19  AARSGNLDKALDHLRNGVDIN--TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76

Query: 683 QQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV 742
           +  T L  A +    EV R +V  G  V ++ + G T L+ AA+  +LE+V  LL  G  
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG-A 135

Query: 743 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAE 801
           + N     G+TP+  A +  H  V+  L+  G     T  +  +  LH A+       A 
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYG-----TKGKVRLPALHIAARNDDTRTAA 190

Query: 802 VLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERS 861
           VLL    +   ++  G TPLHIAA     +   L L+RGA+     + G T   +   R 
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 862 DV 863
           +V
Sbjct: 251 NV 252



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 41/140 (29%), Positives = 73/140 (52%), Gaps = 1/140 (0%)

Query: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
           +E D +T    AA+ GNL+     L  G VD+N  +  G   +  A++  H++++  LL 
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNG-VDINTCNQNGLNGLHLASKEGHVKMVVELLH 66

Query: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 832
           +   +  T  + N  LH A+  G   +   L+N   +++A +  G TPL++AA+E++ + 
Sbjct: 67  KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126

Query: 833 VLLFLSRGANPELRNKEGDT 852
           V   L  GAN  +  ++G T
Sbjct: 127 VKFLLENGANQNVATEDGFT 146



 Score = 38.9 bits (89), Expect = 0.029
 Identities = 38/165 (23%), Positives = 70/165 (42%), Gaps = 7/165 (4%)

Query: 744 VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVL 803
           V  +++   T  + AA   +++     L  G D+   +      LH AS  G   +   L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 804 LNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDV 863
           L+    L      G+T LHIAA     + V   ++ GAN   ++++G T   +  + +  
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH- 123

Query: 864 WFALQLNRKLRLGVGNRAIRTE---KIICRDVARGYENVPIPCVN 905
              L++ + L     N+ + TE     +   + +G+ENV    +N
Sbjct: 124 ---LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN 165


>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
          Length = 722

 Score =  117 bits (293), Expect = 6e-26
 Identities = 77/252 (30%), Positives = 130/252 (51%), Gaps = 6/252 (2%)

Query: 652 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 711
           RTPLH AA KG + +  +LL+AG +++  D   +T L  A V  + E+   ++  G  + 
Sbjct: 43  RTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALD 102

Query: 712 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL 771
            +++DG+T LH A+  G  +   LL+  G  +V A++  G T +  A ++ H +  R+LL
Sbjct: 103 RQDKDGNTALHEASWHGFSQSAKLLVKAG-ANVLAKNKAGNTALHLACQNSHSQSTRVLL 161

Query: 772 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 831
             G+   L +N  + CLH A+     +I  +LL A C +H  N  GDT LH+AA  ++  
Sbjct: 162 LAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKK 221

Query: 832 CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRK---LRLGVGNRAIRTEKII 888
              + L  GA+  + N  G T  +     ++   AL L +    LR   G R++R ++  
Sbjct: 222 VAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRG-RSLRKKRER 280

Query: 889 CRDVARGYENVP 900
            ++  R  ++VP
Sbjct: 281 LKEERRA-QSVP 291



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 45/139 (32%), Positives = 69/139 (49%), Gaps = 4/139 (2%)

Query: 724 AAKIGNLEMVSLLLSTG-QVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDN 782
           AA  G  E V  L++ G +V V      G TP+  AA   H+ V+++LL  G D+ + D+
Sbjct: 17  AAYKGQTENVVQLINKGARVAVTKH---GRTPLHLAANKGHLPVVQILLKAGCDLDVQDD 73

Query: 783 EENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGAN 842
            +   LH A+  G+  I   L++  C L   +  G+T LH A+   +     L +  GAN
Sbjct: 74  GDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGAN 133

Query: 843 PELRNKEGDTAWDLTPERS 861
              +NK G+TA  L  + S
Sbjct: 134 VLAKNKAGNTALHLACQNS 152



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 43/142 (30%), Positives = 66/142 (46%), Gaps = 2/142 (1%)

Query: 636 LLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNN 695
           LL     N  +  ++  T LH A Q    +   VLL AG+  +  +    T L  A   N
Sbjct: 126 LLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYN 185

Query: 696 HLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPI 755
           HL + R ++     V+ K + G T LH AA + + ++  +LL  G  D    ++ G TP+
Sbjct: 186 HLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAG-ADTTIVNNAGQTPL 244

Query: 756 IWAAEHKHIEVIRMLLTRGADV 777
             A  H + EV  +LLT+   V
Sbjct: 245 ETARYHNNPEV-ALLLTKAPQV 265



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 23/68 (33%), Positives = 35/68 (51%)

Query: 633 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 692
           I+ LL     +     Q+  T LH AA     ++  +LL+AGA+   V+   +TPL  A 
Sbjct: 189 IIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETAR 248

Query: 693 VNNHLEVA 700
            +N+ EVA
Sbjct: 249 YHNNPEVA 256


>gi|224177469 SET domain, bifurcated 1 isoform 2 [Homo sapiens]
          Length = 1290

 Score =  112 bits (280), Expect = 2e-24
 Identities = 64/180 (35%), Positives = 97/180 (53%), Gaps = 14/180 (7%)

Query: 891  DVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDC-SSS 949
            D+  G E+VP+ CVN +D  P P+   Y  E      + I+     L  C C D C   S
Sbjct: 681  DITYGKEDVPLSCVNEIDTTPPPQ-VAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKS 739

Query: 950  NCLCGQLSIRCWYDKDGRLLQ-----EFNKIE---PPLIFECNQACSCWRN-CKNRVVQS 1000
             C C QL+I+      G  +      ++ ++E   P  ++ECN+ C C  N C NR+VQ 
Sbjct: 740  KCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQH 799

Query: 1001 GIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEAD---VREDDSYLFDLDN 1057
            G++VRLQL++T   GWG+R L  I +G+F+C Y G++++D  AD   +   D Y  +LD+
Sbjct: 800  GLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDH 859



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 38/86 (44%), Positives = 53/86 (61%), Gaps = 3/86 (3%)

Query: 1059 DGEVYC--IDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEEL 1116
            DGE  C  IDA+  GN+ R++NH C PN+    VF+   DLRFP +AFF+S+ IR G EL
Sbjct: 1202 DGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTEL 1260

Query: 1117 GFDYGDRFWDIKSKYFTCQCGSEKCK 1142
             +DY      ++ K   C CG+ +C+
Sbjct: 1261 TWDYNYEVGSVEGKELLCCCGAIECR 1286


>gi|224177467 SET domain, bifurcated 1 isoform 1 [Homo sapiens]
          Length = 1291

 Score =  112 bits (280), Expect = 2e-24
 Identities = 64/180 (35%), Positives = 97/180 (53%), Gaps = 14/180 (7%)

Query: 891  DVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDC-SSS 949
            D+  G E+VP+ CVN +D  P P+   Y  E      + I+     L  C C D C   S
Sbjct: 681  DITYGKEDVPLSCVNEIDTTPPPQ-VAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKS 739

Query: 950  NCLCGQLSIRCWYDKDGRLLQ-----EFNKIE---PPLIFECNQACSCWRN-CKNRVVQS 1000
             C C QL+I+      G  +      ++ ++E   P  ++ECN+ C C  N C NR+VQ 
Sbjct: 740  KCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQH 799

Query: 1001 GIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEAD---VREDDSYLFDLDN 1057
            G++VRLQL++T   GWG+R L  I +G+F+C Y G++++D  AD   +   D Y  +LD+
Sbjct: 800  GLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDH 859



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 38/86 (44%), Positives = 53/86 (61%), Gaps = 2/86 (2%)

Query: 1059 DGEVYC--IDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEEL 1116
            DGE  C  IDA+  GN+ R++NH C PN+    VF+   DLRFP +AFF+S+ IR G EL
Sbjct: 1202 DGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTEL 1261

Query: 1117 GFDYGDRFWDIKSKYFTCQCGSEKCK 1142
             +DY      ++ K   C CG+ +C+
Sbjct: 1262 TWDYNYEVGSVEGKELLCCCGAIECR 1287


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score =  112 bits (279), Expect = 3e-24
 Identities = 79/236 (33%), Positives = 116/236 (49%), Gaps = 4/236 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+ +   G  Q V L+L  N      SD Q   TPLH AAQ    E   V L+  +  + 
Sbjct: 259 LHWAALLGHAQIVHLLLERNKSGTIPSDSQGA-TPLHYAAQSNFAETVKVFLKHPSVKDD 317

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEED--GSTCLHHAAKIGNLEMVSLLL 737
            D + RT  M A      +V R M+     +     D  G T LH AA  G++  V LLL
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377

Query: 738 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 797
                 V+A D    TP+  A E  H +VI+ L+  GA V L D + +  LHWA+  G+A
Sbjct: 378 ENN-AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA 436

Query: 798 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
            + ++L+  + + +  +Y G TPL  AA   Y +C+ + +   A+P +++KEG TA
Sbjct: 437 DVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTA 492



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 63/216 (29%), Positives = 103/216 (47%), Gaps = 5/216 (2%)

Query: 628 ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTP 687
           ++ + +L L  ++D N         T LHAAA  G V    +LL+  A ++A D  + TP
Sbjct: 336 DVLRTMLSLKSDIDINMADKYGG--TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTP 393

Query: 688 LMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQ 747
           L  A    H +V + +++ G  V   ++DG + LH AA  GN ++  +L+   +++ N Q
Sbjct: 394 LFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEN-KINPNVQ 452

Query: 748 DSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR 807
           D  G TP+  AA   +I  + +L+   AD  + D E    LHW+   G     ++LL+  
Sbjct: 453 DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFA 512

Query: 808 CDLHAV--NYHGDTPLHIAARESYHDCVLLFLSRGA 841
              + +  N    TPL  A     H+ +   L  GA
Sbjct: 513 AFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 75/301 (24%), Positives = 122/301 (40%), Gaps = 46/301 (15%)

Query: 597 ALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLH 656
           AL++ +V   + + K+ +F    L   V    L     +L    D N      S+RT LH
Sbjct: 29  ALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN--KTDHSQRTALH 86

Query: 657 AAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ--RGGCVYSKE 714
            AAQKG+     +LL   AN    D ++ TPL     +   +    +++    G V +++
Sbjct: 87  LAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQD 146

Query: 715 EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKH---IEVIRMLL 771
           ++  T LH +A   N E V LL+     ++   D  G  P+ WAA HK    +  +R +L
Sbjct: 147 KNKQTALHWSAYYNNPEHVKLLIKHDS-NIGIPDVEGKIPLHWAANHKDPSAVHTVRCIL 205

Query: 772 T-------------------------------------RGADVTLTDNEENICLHWASFT 794
                                                    ++T  DN     LHWA+  
Sbjct: 206 DAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALL 265

Query: 795 GSAAIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
           G A I  +LL   +      +  G TPLH AA+ ++ + V +FL   +  +  + EG T+
Sbjct: 266 GHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTS 325

Query: 854 W 854
           +
Sbjct: 326 F 326



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 60/215 (27%), Positives = 93/215 (43%), Gaps = 9/215 (4%)

Query: 636 LLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHV---LLQAGAN---INAVDKQQRTPLM 689
           LL   D N        + PLH AA        H    +L A      +N  D + RTPL 
Sbjct: 167 LLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLH 226

Query: 690 EAVVNNHLEVARYMVQRGGC-VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQD 748
            AV + ++ V   +     C + S +    T LH AA +G+ ++V LLL   +      D
Sbjct: 227 FAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSD 286

Query: 749 SGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR- 807
           S G TP+ +AA+    E +++ L   +    +D E      WA+  GS  +   +L+ + 
Sbjct: 287 SQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKS 346

Query: 808 -CDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA 841
             D++  + +G T LH AA   +   V L L   A
Sbjct: 347 DIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 37/138 (26%), Positives = 61/138 (44%), Gaps = 4/138 (2%)

Query: 721 LHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLT 780
           +H AA  G+   +  L+       + +D  G TP+++      ++    LL  GADV  T
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 781 DNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRG 840
           D+ +   LH A+  G+    ++LL  R +    +    TPLH+  R     C+ L L   
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 841 ANPEL----RNKEGDTAW 854
           A  E+    +NK+    W
Sbjct: 138 APGEVDTQDKNKQTALHW 155


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score =  112 bits (279), Expect = 3e-24
 Identities = 79/236 (33%), Positives = 116/236 (49%), Gaps = 4/236 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+ +   G  Q V L+L  N      SD Q   TPLH AAQ    E   V L+  +  + 
Sbjct: 259 LHWAALLGHAQIVHLLLERNKSGTIPSDSQGA-TPLHYAAQSNFAETVKVFLKHPSVKDD 317

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEED--GSTCLHHAAKIGNLEMVSLLL 737
            D + RT  M A      +V R M+     +     D  G T LH AA  G++  V LLL
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377

Query: 738 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 797
                 V+A D    TP+  A E  H +VI+ L+  GA V L D + +  LHWA+  G+A
Sbjct: 378 ENN-AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA 436

Query: 798 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
            + ++L+  + + +  +Y G TPL  AA   Y +C+ + +   A+P +++KEG TA
Sbjct: 437 DVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTA 492



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 63/216 (29%), Positives = 103/216 (47%), Gaps = 5/216 (2%)

Query: 628 ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTP 687
           ++ + +L L  ++D N         T LHAAA  G V    +LL+  A ++A D  + TP
Sbjct: 336 DVLRTMLSLKSDIDINMADKYGG--TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTP 393

Query: 688 LMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQ 747
           L  A    H +V + +++ G  V   ++DG + LH AA  GN ++  +L+   +++ N Q
Sbjct: 394 LFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEN-KINPNVQ 452

Query: 748 DSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR 807
           D  G TP+  AA   +I  + +L+   AD  + D E    LHW+   G     ++LL+  
Sbjct: 453 DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFA 512

Query: 808 CDLHAV--NYHGDTPLHIAARESYHDCVLLFLSRGA 841
              + +  N    TPL  A     H+ +   L  GA
Sbjct: 513 AFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 75/301 (24%), Positives = 122/301 (40%), Gaps = 46/301 (15%)

Query: 597 ALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLH 656
           AL++ +V   + + K+ +F    L   V    L     +L    D N      S+RT LH
Sbjct: 29  ALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN--KTDHSQRTALH 86

Query: 657 AAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ--RGGCVYSKE 714
            AAQKG+     +LL   AN    D ++ TPL     +   +    +++    G V +++
Sbjct: 87  LAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQD 146

Query: 715 EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKH---IEVIRMLL 771
           ++  T LH +A   N E V LL+     ++   D  G  P+ WAA HK    +  +R +L
Sbjct: 147 KNKQTALHWSAYYNNPEHVKLLIKHDS-NIGIPDVEGKIPLHWAANHKDPSAVHTVRCIL 205

Query: 772 T-------------------------------------RGADVTLTDNEENICLHWASFT 794
                                                    ++T  DN     LHWA+  
Sbjct: 206 DAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALL 265

Query: 795 GSAAIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
           G A I  +LL   +      +  G TPLH AA+ ++ + V +FL   +  +  + EG T+
Sbjct: 266 GHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTS 325

Query: 854 W 854
           +
Sbjct: 326 F 326



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 60/215 (27%), Positives = 93/215 (43%), Gaps = 9/215 (4%)

Query: 636 LLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHV---LLQAGAN---INAVDKQQRTPLM 689
           LL   D N        + PLH AA        H    +L A      +N  D + RTPL 
Sbjct: 167 LLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLH 226

Query: 690 EAVVNNHLEVARYMVQRGGC-VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQD 748
            AV + ++ V   +     C + S +    T LH AA +G+ ++V LLL   +      D
Sbjct: 227 FAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSD 286

Query: 749 SGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR- 807
           S G TP+ +AA+    E +++ L   +    +D E      WA+  GS  +   +L+ + 
Sbjct: 287 SQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKS 346

Query: 808 -CDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA 841
             D++  + +G T LH AA   +   V L L   A
Sbjct: 347 DIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 37/138 (26%), Positives = 61/138 (44%), Gaps = 4/138 (2%)

Query: 721 LHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLT 780
           +H AA  G+   +  L+       + +D  G TP+++      ++    LL  GADV  T
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 781 DNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRG 840
           D+ +   LH A+  G+    ++LL  R +    +    TPLH+  R     C+ L L   
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 841 ANPEL----RNKEGDTAW 854
           A  E+    +NK+    W
Sbjct: 138 APGEVDTQDKNKQTALHW 155


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  110 bits (275), Expect = 8e-24
 Identities = 107/375 (28%), Positives = 161/375 (42%), Gaps = 48/375 (12%)

Query: 519 GVTP-PAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLT 577
           GV P PAG+ +   P  S   P  + +S PS+           P   LA++ +++G S T
Sbjct: 115 GVAPNPAGSGSNNSPSSSSS-PTSSSSSSPSS-----------PGSSLAESPEAAGVSST 162

Query: 578 LP--NGGCLSAVGLPLGPG--REALE----------KALVIQESERRKKLRFHPRQLYLS 623
            P   G      G+P   G  RE LE          K LV   +   K +    +   L 
Sbjct: 163 APLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGR-KSSPLH 221

Query: 624 VKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQ 683
              G  +K ++  L  +  N  +       PLH A   G  E+  +LL  GA+ NA D  
Sbjct: 222 FAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNW 281

Query: 684 QRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLH--------------------H 723
             TPL EA +   ++V   ++Q G     +  DG + L                      
Sbjct: 282 NYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLE 341

Query: 724 AAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNE 783
           AA+ GN E +  LL+   V+ +A D    TP+  AA +  + ++++LL  GADV   D  
Sbjct: 342 AARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKG 401

Query: 784 ENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 843
             + LH A   G   + E+LL     ++A++    TPLH AA ++  +   L LS GA+P
Sbjct: 402 GLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADP 461

Query: 844 ELRNKEGDTAWDLTP 858
            L N  G +A D+ P
Sbjct: 462 TLVNCHGKSAVDMAP 476



 Score =  100 bits (250), Expect = 6e-21
 Identities = 69/223 (30%), Positives = 102/223 (45%), Gaps = 20/223 (8%)

Query: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 713
           PLH A   G  E+  +L++ GA++N  D  + TPL EA      E+ + +++ G     K
Sbjct: 720 PLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKK 779

Query: 714 EEDGST--------------------CLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWT 753
             DG+T                     L  AAK G L  V  L +   ++         T
Sbjct: 780 NRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNST 839

Query: 754 PIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 813
           P+  AA + ++EV   LL  GADV   D    I LH A+  G   IA +L+     ++A 
Sbjct: 840 PLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNAT 899

Query: 814 NYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDL 856
           +    TPLH AA++       L L+ GA+P ++N+EG T  DL
Sbjct: 900 DKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDL 942



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 86/317 (27%), Positives = 131/317 (41%), Gaps = 46/317 (14%)

Query: 630 QKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLM 689
           +K +  LL     N     +   TPLH AA++   ++  VL + GA +NA+D   +T L 
Sbjct: 537 RKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALH 596

Query: 690 EAVVNNHLEVARYMVQRGGCVYSKEEDGSTC--------------------------LHH 723
            A +  HL+  R ++  G         G T                           L  
Sbjct: 597 RAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLE 656

Query: 724 AAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNE 783
           A+K G+LE V  L S+  V+    +    TP+ +AA +  + V+  LL  GADV   D  
Sbjct: 657 ASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKG 716

Query: 784 ENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 843
             + LH A   G   +AE+L+     ++  +    TPLH AA +  ++   L L  GA+P
Sbjct: 717 GLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADP 776

Query: 844 ELRNKEGDTAWDLTPE---------RSDVWFALQLNRKLRLGVGNRAIRTEKIICRD--- 891
             +N++G+T  DL  E         R D    L   +K  L    +    E I CRD   
Sbjct: 777 TKKNRDGNTPLDLVKEGDTDIQDLLRGDA-ALLDAAKKGCLARVQKLCTPENINCRDTQG 835

Query: 892 -------VARGYENVPI 901
                  +A GY N+ +
Sbjct: 836 RNSTPLHLAAGYNNLEV 852



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 38/113 (33%), Positives = 62/113 (54%), Gaps = 1/113 (0%)

Query: 643 NFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARY 702
           N +  Q    TPLH AA   ++E+   LL+ GA++NA DK    PL  A    H+++A  
Sbjct: 829 NCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAAL 888

Query: 703 MVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPI 755
           +++   CV + ++   T LH AA+ G  ++ +LLL+ G  D   ++  G TP+
Sbjct: 889 LIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTMKNQEGQTPL 940



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 78/319 (24%), Positives = 132/319 (41%), Gaps = 40/319 (12%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+L+     ++ V L+L    D +  +  +    PLH A   G  E+  +LL+ GA +NA
Sbjct: 373 LHLAAGYNRVRIVQLLLQHGADVH--AKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA 430

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTC------------------- 720
           +D  Q TPL EA   N +EV   ++  G         G +                    
Sbjct: 431 MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKG 490

Query: 721 --LHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTP--IIWAAEHKHIEVIRMLLTRGAD 776
             L  AA+  +L  V   L+   ++     S        + +   K  +V  +LL +GA+
Sbjct: 491 HSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGAN 550

Query: 777 VTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLF 836
           V   + +    LH A+      + EVL      ++A++  G T LH AA   +     L 
Sbjct: 551 VNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610

Query: 837 LSRGANPELRNKEGDTAWDL------------TPER-SDV-WFALQLNRKLRLGVGNRAI 882
           LS G++P + + +G TA  +            TP R SDV +  L+ ++   L    +  
Sbjct: 611 LSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLC 670

Query: 883 RTEKIICRDVARGYENVPI 901
            ++ + CRD+  G  + P+
Sbjct: 671 SSQNVNCRDL-EGRHSTPL 688


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  110 bits (275), Expect = 8e-24
 Identities = 67/198 (33%), Positives = 101/198 (51%), Gaps = 1/198 (0%)

Query: 653 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 712
           TPL  AA +G V++  +LL+ GA+++  D   RTPL+ A    H  V   ++  G  V S
Sbjct: 750 TPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS 809

Query: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
            + +G T L  A+  GN+E+V  LL  G +D N +D  GWTP+  AA   H  +   L+ 
Sbjct: 810 IDSEGRTVLSIASAQGNVEVVRTLLDRG-LDENHRDDAGWTPLHMAAFEGHRLICEALIE 868

Query: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 832
           +GA     DN+  I    AS  G     ++LL  + ++    Y G   L +AA E + D 
Sbjct: 869 QGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDI 928

Query: 833 VLLFLSRGANPELRNKEG 850
           V L  S GA+   ++ +G
Sbjct: 929 VELLFSHGADVNCKDADG 946



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 61/195 (31%), Positives = 100/195 (51%), Gaps = 1/195 (0%)

Query: 659 AQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGS 718
           A KG   +  +L+  GA ++  DK   TPL+ A    H++V   +++ G  V   + +G 
Sbjct: 723 ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR 782

Query: 719 TCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVT 778
           T L  AA +G+  +V+ LL  G   V++ DS G T +  A+   ++EV+R LL RG D  
Sbjct: 783 TPLLAAASMGHASVVNTLLFWGAA-VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN 841

Query: 779 LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 838
             D+     LH A+F G   I E L+      + ++  G  P  +A++E ++DCV + L 
Sbjct: 842 HRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE 901

Query: 839 RGANPELRNKEGDTA 853
             +N + R  +G  A
Sbjct: 902 NKSNIDQRGYDGRNA 916



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 76/267 (28%), Positives = 122/267 (45%), Gaps = 36/267 (13%)

Query: 620  LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
            L ++  QG ++ V  +L   LD N + D  +  TPLH AA +G   IC  L++ GA  N 
Sbjct: 818  LSIASAQGNVEVVRTLLDRGLDENHRDD--AGWTPLHMAAFEGHRLICEALIEQGARTNE 875

Query: 680  VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            +D   R P + A    H +  + +++    +  +  DG   L  AA  G+ ++V LL S 
Sbjct: 876  IDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSH 935

Query: 740  GQVDVNAQDSGGW-TPIIWAAEHK--------------------------------HIEV 766
            G  DVN +D+ G  T  I A E++                                H+E+
Sbjct: 936  G-ADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEM 994

Query: 767  IRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAAR 826
            +++L+   ADV   DNE+   L  A++ G   + ++L+     +      G T L IAA+
Sbjct: 995  VQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQ 1054

Query: 827  ESYHDCVLLFLSRGANPELRNKEGDTA 853
            E + D V + L  GA+P   ++ G TA
Sbjct: 1055 EGHIDVVQVLLEHGADPNHADQFGRTA 1081



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 74/230 (32%), Positives = 112/230 (48%), Gaps = 7/230 (3%)

Query: 628 ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTP 687
           E +  I  LLDN     Q D    RT L  AA  GS+++ ++L+  GA++   D    TP
Sbjct: 523 EREDSIRTLLDNGASVNQCDSNG-RTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTP 581

Query: 688 LMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQ 747
           L  A    H +V   ++  G  +   ++DG T L  AA  G+ E+VS LL  G V V+  
Sbjct: 582 LTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAG-VKVDCA 640

Query: 748 DSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR 807
           D+   T +  AA   H +++  LL  GA+V   DNE    L  A++ G   I E LL+  
Sbjct: 641 DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700

Query: 808 CDLHAVNYHGDTPLHIA-----ARESYHDCVLLFLSRGANPELRNKEGDT 852
            +++  +  G T L +A     A + +   V L + RGA  +  +K+G T
Sbjct: 701 AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMT 750



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 72/249 (28%), Positives = 112/249 (44%), Gaps = 8/249 (3%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L L+ +QG  + V  ++      N     Q   T L +AA  G  E+   LL AG  ++ 
Sbjct: 582 LTLAARQGHTKVVNCLI--GCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDC 639

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            D   RT L  A    H ++   ++Q G  V   + +G T L  AA +G+ E+V  LL  
Sbjct: 640 ADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDH 699

Query: 740 GQVDVNAQDSGGWTPIIWAA-----EHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 794
           G  +VN +D  G T +  AA        H  V+ +L+ RGA+V   D +    L  A++ 
Sbjct: 700 G-AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYE 758

Query: 795 GSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAW 854
           G   + ++LL    D+   + +G TPL  AA   +   V   L  GA  +  + EG T  
Sbjct: 759 GHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVL 818

Query: 855 DLTPERSDV 863
            +   + +V
Sbjct: 819 SIASAQGNV 827



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 73/270 (27%), Positives = 128/270 (47%), Gaps = 3/270 (1%)

Query: 584 LSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPN 643
           ++A+ +P   G  ++   L+ + +E     +     L ++  +G +  V L+L    D +
Sbjct: 716 VAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD 775

Query: 644 FQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYM 703
              +  + RTPL AAA  G   + + LL  GA ++++D + RT L  A    ++EV R +
Sbjct: 776 HTDN--NGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833

Query: 704 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKH 763
           + RG     +++ G T LH AA  G+  +   L+  G    N  D+ G  P I A++  H
Sbjct: 834 LDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG-ARTNEIDNDGRIPFILASQEGH 892

Query: 764 IEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 823
            + +++LL   +++     +    L  A+  G   I E+L +   D++  +  G   L+I
Sbjct: 893 YDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYI 952

Query: 824 AARESYHDCVLLFLSRGANPELRNKEGDTA 853
            A E+       FL  GAN E  + EG TA
Sbjct: 953 LALENQLTMAEYFLENGANVEASDAEGRTA 982



 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 65/240 (27%), Positives = 114/240 (47%), Gaps = 2/240 (0%)

Query: 603  VIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKG 662
            +I++  R  ++    R  ++   Q      + +LL+N   N        R  L  AA +G
Sbjct: 866  LIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKS-NIDQRGYDGRNALRVAALEG 924

Query: 663  SVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLH 722
              +I  +L   GA++N  D   R  L    + N L +A Y ++ G  V + + +G T LH
Sbjct: 925  HRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALH 984

Query: 723  HAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDN 782
             +   G++EMV +L++    DVNA D+   + +  AA   H++V+++L+  GA V  T N
Sbjct: 985  VSCWQGHMEMVQVLIAY-HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCN 1043

Query: 783  EENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGAN 842
            +    L  A+  G   + +VLL    D +  +  G T + +AA+  +   + L    GA+
Sbjct: 1044 QGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 57/189 (30%), Positives = 96/189 (50%), Gaps = 3/189 (1%)

Query: 665 EICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHA 724
           E+  +L++AGA++N+ D +    + +A+     +  R ++  G  V   + +G T L +A
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLANA 552

Query: 725 AKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEE 784
           A  G+L++V+LL+S G  D+  +D+ G TP+  AA   H +V+  L+  GA++  TD + 
Sbjct: 553 AYSGSLDVVNLLVSRG-ADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611

Query: 785 NICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPE 844
              L  A++ G   +   LL A   +   +    T L  AA   + D VL  L  GA   
Sbjct: 612 WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671

Query: 845 LRNKEGDTA 853
             + EG TA
Sbjct: 672 KADNEGRTA 680



 Score = 80.5 bits (197), Expect = 9e-15
 Identities = 57/184 (30%), Positives = 86/184 (46%), Gaps = 1/184 (0%)

Query: 670 LLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGN 729
           LL  GA++N  D   RT L  A  +  L+V   +V RG  +  ++  G T L  AA+ G+
Sbjct: 531 LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590

Query: 730 LEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLH 789
            ++V+ L+  G  ++N  D  GWT +  AA   H EV+  LL  G  V   D +    L 
Sbjct: 591 TKVVNCLIGCG-ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALR 649

Query: 790 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 849
            A++ G   I   LL    +++  +  G T L  AA   + + V   L  GA     + +
Sbjct: 650 AAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVD 709

Query: 850 GDTA 853
           G TA
Sbjct: 710 GRTA 713



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 34/126 (26%), Positives = 68/126 (53%), Gaps = 2/126 (1%)

Query: 620  LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
            L++S  QG ++ V +++  + D N   ++  KR+ L +AA +G V++  +L++ GA ++ 
Sbjct: 983  LHVSCWQGHMEMVQVLIAYHADVNAADNE--KRSALQSAAWQGHVKVVQLLIEHGAVVDH 1040

Query: 680  VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
               Q  T L  A    H++V + +++ G      ++ G T +  AAK G+ +++ LL   
Sbjct: 1041 TCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKY 1100

Query: 740  GQVDVN 745
            G   +N
Sbjct: 1101 GASSLN 1106


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  109 bits (273), Expect = 1e-23
 Identities = 87/281 (30%), Positives = 134/281 (47%), Gaps = 4/281 (1%)

Query: 576 LTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILM 635
           L L +G  L  + L +  G+E   K L++  +      R     L+++V++     V L+
Sbjct: 433 LALDSGASL--LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490

Query: 636 LLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNN 695
           L   +  N + + Q   T LH AAQ G      +LL+  A++N VD + RTP+  A  + 
Sbjct: 491 LARKISVNAKDEDQW--TALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHG 548

Query: 696 HLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPI 755
              + R +++RG  V  + +D    LH+AA  G+L +V LL     V VNAQ   G TP+
Sbjct: 549 QENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPL 608

Query: 756 IWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNY 815
             AA+  H  V R+L+   +DV +        LH A+ TG  + A +LL+      A+  
Sbjct: 609 HLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTS 668

Query: 816 HGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDL 856
            G T LH+AAR  +   V L +   A+   R     TA  L
Sbjct: 669 DGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHL 709



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 68/248 (27%), Positives = 117/248 (47%), Gaps = 6/248 (2%)

Query: 602 LVIQESERRKKLRFHPRQ-LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQ 660
           L+++++    ++ F  R  ++++ + G+   V ++L   +D + Q   +    PLH AA 
Sbjct: 522 LLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG--KDAWLPLHYAAW 579

Query: 661 KGSVEICHVLL-QAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGST 719
           +G + I  +L  Q G ++NA     RTPL  A    H  VAR ++     V        T
Sbjct: 580 QGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQT 639

Query: 720 CLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTL 779
            LH AA+ G+     LLL  G     A  S G+T +  AA + H+  +++L+   ADV  
Sbjct: 640 PLHVAAETGHTSTARLLLHRG-AGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLA 698

Query: 780 TDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSR 839
                   LH A+  G + + E L++A   +   +  G + LH+AA+  +   V   L  
Sbjct: 699 RGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRH 757

Query: 840 GANPELRN 847
           GA+  L++
Sbjct: 758 GAHINLQS 765



 Score = 33.9 bits (76), Expect = 0.94
 Identities = 33/125 (26%), Positives = 54/125 (43%), Gaps = 2/125 (1%)

Query: 728 GNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 787
           G+   +  +L    VD+ A DSG  + +  A E    E  + LL   A+  L++   +  
Sbjct: 417 GDTSKLMKILQPQDVDL-ALDSGA-SLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTP 474

Query: 788 LHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 847
           LH A       + E+LL  +  ++A +    T LH AA+        L L + A+    +
Sbjct: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534

Query: 848 KEGDT 852
            EG T
Sbjct: 535 FEGRT 539



 Score = 33.9 bits (76), Expect = 0.94
 Identities = 25/94 (26%), Positives = 39/94 (41%)

Query: 769 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARES 828
           M + +  DV L  +     LH A   G    A+ LL    + +  N  G TPLH+A    
Sbjct: 423 MKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERR 482

Query: 829 YHDCVLLFLSRGANPELRNKEGDTAWDLTPERSD 862
               V L L+R  +   ++++  TA     +  D
Sbjct: 483 VRGVVELLLARKISVNAKDEDQWTALHFAAQNGD 516


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  108 bits (270), Expect = 3e-23
 Identities = 77/233 (33%), Positives = 118/233 (50%), Gaps = 3/233 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+  V QG +++V L+L   +D + Q+   S  TPL  AAQ    ++C +LL  GA+ N 
Sbjct: 366 LHFLVAQGSVEQVRLLLAHEVDVDCQT--ASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
           VD+    PL  A  N     AR ++  G CV ++E +G T LH AA+  N E V+ LL +
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQ-NNFENVARLLVS 482

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
            Q D N  ++ G TP+  AA   H+ ++++L ++GA++          LH A   G    
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
            + LL +     A++  G  PLH AA    +    + L  GA+ EL   +G T
Sbjct: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWT 595



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 70/233 (30%), Positives = 106/233 (45%), Gaps = 3/233 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+L+ +        L++    DPN    +   +TPLH AA  G V +  +L   GA ++A
Sbjct: 465 LHLAAQNNFENVARLLVSRQADPNLH--EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDA 522

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             +  RTPL  AV    +   +++++ G    + ++ G   LH AA  G   +  +LL  
Sbjct: 523 QQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRY 582

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
           G   +      GWTP+  AA   H+E+I +L    A++          LH A+  G  A+
Sbjct: 583 G-ASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAV 641

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
              LL    D +A    G TPLH+A + S    V+  L   AN   RNK G T
Sbjct: 642 VSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWT 694



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 62/202 (30%), Positives = 101/202 (50%), Gaps = 1/202 (0%)

Query: 649 QSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGG 708
           ++K TPLH    +GSVE   +LL    +++       TPL+ A  +   ++   ++  G 
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 709 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 768
                +EDG   LH AA+ G+     LLL  G   V+AQ+  GWTP+  AA++    V R
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGAC-VDAQEREGWTPLHLAAQNNFENVAR 478

Query: 769 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARES 828
           +L++R AD  L + E    LH A++ G  ++ ++L +   +L A   +  TPLH+A    
Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERG 538

Query: 829 YHDCVLLFLSRGANPELRNKEG 850
               +   L  GA P+  ++ G
Sbjct: 539 KVRAIQHLLKSGAVPDALDQSG 560



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 73/240 (30%), Positives = 105/240 (43%), Gaps = 32/240 (13%)

Query: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 713
           PLH AAQ G      +LL  GA ++A +++  TPL  A  NN   VAR +V R       
Sbjct: 431 PLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH 490

Query: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTG-QVDV---------------------------- 744
           E +G T LH AA  G++ +V LL S G ++D                             
Sbjct: 491 EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550

Query: 745 ---NAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAE 801
              +A D  G+ P+  AA      + +MLL  GA + L  ++    LH A++ G   I  
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610

Query: 802 VLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERS 861
           +L  +  ++ A+     TPLH+AAR      V   L  GA+P    + G T   L  +RS
Sbjct: 611 LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRS 670



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 61/191 (31%), Positives = 98/191 (51%), Gaps = 9/191 (4%)

Query: 667 CHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEE-----DGSTCL 721
           C + L+    +N    Q+   LM++   N+L+ A  +  R   V   EE     +  T L
Sbjct: 310 CKLSLRQPGEVNEDISQE---LMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPL 366

Query: 722 HHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTD 781
           H     G++E V LLL+  +VDV+ Q + G+TP++ AA+ +  ++  +LL  GAD    D
Sbjct: 367 HFLVAQGSVEQVRLLLAH-EVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVD 425

Query: 782 NEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA 841
            +    LH+A+  G    A +LL+    + A    G TPLH+AA+ ++ +   L +SR A
Sbjct: 426 EDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQA 485

Query: 842 NPELRNKEGDT 852
           +P L   EG T
Sbjct: 486 DPNLHEAEGKT 496



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 61/215 (28%), Positives = 102/215 (47%), Gaps = 1/215 (0%)

Query: 633 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 692
           ++ LL +      + Q++ RTPLH A ++G V     LL++GA  +A+D+    PL  A 
Sbjct: 509 LVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAA 568

Query: 693 VNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGW 752
                 + + +++ G  +      G T LH AA  G+LE++  LL+    ++ A  +  W
Sbjct: 569 ARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH-LLAESHANMGALGAVNW 627

Query: 753 TPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHA 812
           TP+  AA H    V+  LL  GAD    +      LH A    +      LL    ++HA
Sbjct: 628 TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHA 687

Query: 813 VNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 847
            N  G TP H+AA +     + + +  GA  ++++
Sbjct: 688 RNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 36/118 (30%), Positives = 55/118 (46%), Gaps = 7/118 (5%)

Query: 580 NGGCLSAVG-----LPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVIL 634
           N G L AV      L    G EA+  AL+   ++     +     L+L+V++     VI 
Sbjct: 618 NMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVIN 677

Query: 635 MLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 692
           +L  +   N  +  +   TP H AA KG+  I  VL++AGA ++  D    TPL  A+
Sbjct: 678 LLEHHA--NVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLAL 733


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  108 bits (270), Expect = 3e-23
 Identities = 74/250 (29%), Positives = 127/250 (50%), Gaps = 3/250 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ K+  ++  ++ LL     + Q+  +S  TP+H AA  G + I  +LLQ GA+ + 
Sbjct: 381 LHIACKKNRIK--VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            + +  T L  A     +EV R +++ G  V ++  +  T LH A+++G  E+V LLL  
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
                +A  + G+TP+  +A    ++V  +LL  GA  +L   +    LH A+  GS  +
Sbjct: 499 -MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 557

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
           A++LL  R    +   +G TPLH+AA        LL L +GA+P    K G T   +  +
Sbjct: 558 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 617

Query: 860 RSDVWFALQL 869
           ++ +  A  L
Sbjct: 618 KNQMQIASTL 627



 Score =  107 bits (268), Expect = 5e-23
 Identities = 74/244 (30%), Positives = 124/244 (50%), Gaps = 3/244 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ + G+++ V  +L +    + ++ ++  +TPLH A++ G  EI  +LLQ  A+ +A
Sbjct: 447 LHMAARAGQVEVVRCLLRNGALVDARAREE--QTPLHIASRLGKTEIVQLLLQHMAHPDA 504

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
                 TPL  +     ++VA  +++ G       + G T LH AAK G+L++  LLL  
Sbjct: 505 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 564

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
            +   ++    G TP+  AA + + +V  +LL +GA    T       LH A+      I
Sbjct: 565 -RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 623

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
           A  LLN   + + V   G TPLH+A++E + D V L L +GAN  +  K G T+  L  +
Sbjct: 624 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 683

Query: 860 RSDV 863
              V
Sbjct: 684 EDKV 687



 Score =  103 bits (257), Expect = 1e-21
 Identities = 80/267 (29%), Positives = 119/267 (44%), Gaps = 38/267 (14%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+L+ K+G +  V  +L      +  S  +   T LH A+  G  E+  VL++ GANINA
Sbjct: 47  LHLAAKEGHVGLVQELL--GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA 104

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             +   TPL  A   NH++V +Y+++ G    +  EDG T L  A + G+ + V++LL  
Sbjct: 105 QSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 164

Query: 740 ------------------------------------GQVDVNAQDSGGWTPIIWAAEHKH 763
                                                ++ VN     G+TP+  AA + +
Sbjct: 165 DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 224

Query: 764 IEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 823
           + V  +LL RGA V  T       LH AS  G+  + ++LL+    + A    G TPLH 
Sbjct: 225 VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 284

Query: 824 AARESYHDCVLLFLSRGANPELRNKEG 850
           AAR  +   V L L RGA    R K G
Sbjct: 285 AARSGHDQVVELLLERGAPLLARTKNG 311



 Score =  102 bits (254), Expect = 2e-21
 Identities = 73/200 (36%), Positives = 96/200 (48%), Gaps = 1/200 (0%)

Query: 653 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 712
           T LH AA  G   +  +LL   AN NA      TPL  A   N ++V   +V+ G  + +
Sbjct: 346 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 405

Query: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
             E G T +H AA +G+L +V LLL  G    +  +  G T +  AA    +EV+R LL 
Sbjct: 406 ITESGLTPIHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLR 464

Query: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 832
            GA V     EE   LH AS  G   I ++LL       A   +G TPLHI+ARE   D 
Sbjct: 465 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 524

Query: 833 VLLFLSRGANPELRNKEGDT 852
             + L  GA   L  K+G T
Sbjct: 525 ASVLLEAGAAHSLATKKGFT 544



 Score =  102 bits (253), Expect = 3e-21
 Identities = 71/233 (30%), Positives = 118/233 (50%), Gaps = 3/233 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ + G+ + V L+L     P+  +   +  TPLH +A++G V++  VLL+AGA  + 
Sbjct: 480 LHIASRLGKTEIVQLLLQHMAHPDAATT--NGYTPLHISAREGQVDVASVLLEAGAAHSL 537

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             K+  TPL  A     L+VA+ ++QR     S  ++G T LH AA   N ++  LLL  
Sbjct: 538 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 597

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
           G    +A    G+TP+  AA+   +++   LL  GA+  +   +    LH AS  G   +
Sbjct: 598 G-ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 656

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
             +LL+   ++H     G T LH+AA+E   +   +    GA+ +   K G T
Sbjct: 657 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 709



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 65/233 (27%), Positives = 118/233 (50%), Gaps = 3/233 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L++S ++G++    ++L      +  + +    TPLH AA+ GS+++  +LLQ  A  ++
Sbjct: 513 LHISAREGQVDVASVLLEAGAAHSLATKKGF--TPLHVAAKYGSLDVAKLLLQRRAAADS 570

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             K   TPL  A   ++ +VA  ++++G   ++  ++G T LH AAK   +++ S LL+ 
Sbjct: 571 AGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 630

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
           G  + N     G TP+  A++  H +++ +LL +GA++ ++       LH A+      +
Sbjct: 631 G-AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 689

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
           A++L     D  A    G TPL +A        V   L +GAN   + K G T
Sbjct: 690 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 742



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 64/200 (32%), Positives = 100/200 (50%), Gaps = 2/200 (1%)

Query: 630 QKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLM 689
           QKV L+LL+    +  +  ++  TPLH AA+K  ++I   LL  GA  N V KQ  TPL 
Sbjct: 588 QKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 646

Query: 690 EAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDS 749
            A    H ++   ++ +G  ++   + G T LH AA+   + +  +L   G  D +A   
Sbjct: 647 LASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG-ADQDAHTK 705

Query: 750 GGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCD 809
            G+TP+I A  + +++++  LL +GA+V          LH A+  G   I  VLL     
Sbjct: 706 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 765

Query: 810 LHAVNYHGDTPLHIAARESY 829
            +A   +G+T L IA R  Y
Sbjct: 766 PNATTANGNTALAIAKRLGY 785



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 72/253 (28%), Positives = 115/253 (45%), Gaps = 3/253 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++   G  +   L+L    +PN ++   +  TPLH A +K  +++  +L++ GA+I A
Sbjct: 348 LHVAAHCGHYRVTKLLLDKRANPNARA--LNGFTPLHIACKKNRIKVMELLVKYGASIQA 405

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
           + +   TP+  A    HL +   ++Q G         G T LH AA+ G +E+V  LL  
Sbjct: 406 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
           G + V+A+     TP+  A+     E++++LL   A            LH ++  G   +
Sbjct: 466 GAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 524

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
           A VLL A          G TPLH+AA+    D   L L R A  +   K G T   +   
Sbjct: 525 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 584

Query: 860 RSDVWFALQLNRK 872
             +   AL L  K
Sbjct: 585 YDNQKVALLLLEK 597



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 66/244 (27%), Positives = 118/244 (48%), Gaps = 3/244 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++   G +    L+L      +F +  ++  TPLH A+++G+  +  +LL  G  I+A
Sbjct: 216 LHIAAHYGNVNVATLLLNRGAAVDFTA--RNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             +   TPL  A  + H +V   +++RG  + ++ ++G + LH AA+  ++E V  LL  
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ- 332

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
            +  V+       T +  AA   H  V ++LL + A+           LH A       +
Sbjct: 333 HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 392

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
            E+L+     + A+   G TP+H+AA   + + VLL L  GA+P++ N  G+TA  +   
Sbjct: 393 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 452

Query: 860 RSDV 863
              V
Sbjct: 453 AGQV 456



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 45/140 (32%), Positives = 76/140 (54%), Gaps = 1/140 (0%)

Query: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
           ++ D +     AA+ GNL+ V   L  G +D+N  +  G   +  AA+  H+ +++ LL 
Sbjct: 6   QKSDSNASFLRAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLG 64

Query: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 832
           RG+ V     + N  LH AS  G A + +VL+    +++A + +G TPL++AA+E++ D 
Sbjct: 65  RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 124

Query: 833 VLLFLSRGANPELRNKEGDT 852
           V   L  GAN     ++G T
Sbjct: 125 VKYLLENGANQSTATEDGFT 144



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 65/249 (26%), Positives = 117/249 (46%), Gaps = 17/249 (6%)

Query: 623 SVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDK 682
           + + G L KV+  L   +D N  +  Q+    LH AA++G V +   LL  G+++++  K
Sbjct: 17  AARAGNLDKVVEYLKGGIDIN--TCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 74

Query: 683 QQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV 742
           +  T L  A +    EV + +V+ G  + ++ ++G T L+ AA+  ++++V  LL  G  
Sbjct: 75  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134

Query: 743 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAE 801
              A + G +TP+  A +  H + + +LL        T  +  +  LH A+       A 
Sbjct: 135 QSTATEDG-FTPLAVALQQGHNQAVAILLEND-----TKGKVRLPALHIAARKDDTKSAA 188

Query: 802 VLLN--------ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
           +LL         ++  ++     G TPLHIAA     +   L L+RGA  +   + G T 
Sbjct: 189 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 248

Query: 854 WDLTPERSD 862
             +  +R +
Sbjct: 249 LHVASKRGN 257



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 48/161 (29%), Positives = 85/161 (52%), Gaps = 3/161 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+L+ ++G    V L+L  +   N     +S  T LH AAQ+  V +  +L + GA+ +A
Sbjct: 645 LHLASQEGHTDMVTLLL--DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             K   TPL+ A    ++++  +++++G  V +K ++G T LH AA+ G+  ++++LL  
Sbjct: 703 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 762

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLT 780
           G    NA  + G T +  A    +I V+  L     +VT T
Sbjct: 763 G-AKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTT 802



 Score = 34.7 bits (78), Expect = 0.55
 Identities = 21/75 (28%), Positives = 36/75 (48%)

Query: 779 LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 838
           L  ++ N     A+  G+       L    D++  N +G   LH+AA+E +   V   L 
Sbjct: 5   LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64

Query: 839 RGANPELRNKEGDTA 853
           RG++ +   K+G+TA
Sbjct: 65  RGSSVDSATKKGNTA 79


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  108 bits (270), Expect = 3e-23
 Identities = 74/250 (29%), Positives = 127/250 (50%), Gaps = 3/250 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ K+  ++  ++ LL     + Q+  +S  TP+H AA  G + I  +LLQ GA+ + 
Sbjct: 402 LHIACKKNRIK--VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            + +  T L  A     +EV R +++ G  V ++  +  T LH A+++G  E+V LLL  
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
                +A  + G+TP+  +A    ++V  +LL  GA  +L   +    LH A+  GS  +
Sbjct: 520 -MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
           A++LL  R    +   +G TPLH+AA        LL L +GA+P    K G T   +  +
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638

Query: 860 RSDVWFALQL 869
           ++ +  A  L
Sbjct: 639 KNQMQIASTL 648



 Score =  107 bits (268), Expect = 5e-23
 Identities = 74/244 (30%), Positives = 124/244 (50%), Gaps = 3/244 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ + G+++ V  +L +    + ++ ++  +TPLH A++ G  EI  +LLQ  A+ +A
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREE--QTPLHIASRLGKTEIVQLLLQHMAHPDA 525

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
                 TPL  +     ++VA  +++ G       + G T LH AAK G+L++  LLL  
Sbjct: 526 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
            +   ++    G TP+  AA + + +V  +LL +GA    T       LH A+      I
Sbjct: 586 -RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 644

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
           A  LLN   + + V   G TPLH+A++E + D V L L +GAN  +  K G T+  L  +
Sbjct: 645 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 704

Query: 860 RSDV 863
              V
Sbjct: 705 EDKV 708



 Score =  103 bits (257), Expect = 1e-21
 Identities = 80/267 (29%), Positives = 119/267 (44%), Gaps = 38/267 (14%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+L+ K+G +  V  +L      +  S  +   T LH A+  G  E+  VL++ GANINA
Sbjct: 68  LHLAAKEGHVGLVQELL--GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA 125

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             +   TPL  A   NH++V +Y+++ G    +  EDG T L  A + G+ + V++LL  
Sbjct: 126 QSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185

Query: 740 ------------------------------------GQVDVNAQDSGGWTPIIWAAEHKH 763
                                                ++ VN     G+TP+  AA + +
Sbjct: 186 DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 245

Query: 764 IEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 823
           + V  +LL RGA V  T       LH AS  G+  + ++LL+    + A    G TPLH 
Sbjct: 246 VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 305

Query: 824 AARESYHDCVLLFLSRGANPELRNKEG 850
           AAR  +   V L L RGA    R K G
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNG 332



 Score =  102 bits (254), Expect = 2e-21
 Identities = 73/200 (36%), Positives = 96/200 (48%), Gaps = 1/200 (0%)

Query: 653 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 712
           T LH AA  G   +  +LL   AN NA      TPL  A   N ++V   +V+ G  + +
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426

Query: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
             E G T +H AA +G+L +V LLL  G    +  +  G T +  AA    +EV+R LL 
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLR 485

Query: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 832
            GA V     EE   LH AS  G   I ++LL       A   +G TPLHI+ARE   D 
Sbjct: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545

Query: 833 VLLFLSRGANPELRNKEGDT 852
             + L  GA   L  K+G T
Sbjct: 546 ASVLLEAGAAHSLATKKGFT 565



 Score =  102 bits (253), Expect = 3e-21
 Identities = 71/233 (30%), Positives = 118/233 (50%), Gaps = 3/233 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ + G+ + V L+L     P+  +   +  TPLH +A++G V++  VLL+AGA  + 
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATT--NGYTPLHISAREGQVDVASVLLEAGAAHSL 558

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             K+  TPL  A     L+VA+ ++QR     S  ++G T LH AA   N ++  LLL  
Sbjct: 559 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 618

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
           G    +A    G+TP+  AA+   +++   LL  GA+  +   +    LH AS  G   +
Sbjct: 619 G-ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 677

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
             +LL+   ++H     G T LH+AA+E   +   +    GA+ +   K G T
Sbjct: 678 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 65/233 (27%), Positives = 118/233 (50%), Gaps = 3/233 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L++S ++G++    ++L      +  + +    TPLH AA+ GS+++  +LLQ  A  ++
Sbjct: 534 LHISAREGQVDVASVLLEAGAAHSLATKKGF--TPLHVAAKYGSLDVAKLLLQRRAAADS 591

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             K   TPL  A   ++ +VA  ++++G   ++  ++G T LH AAK   +++ S LL+ 
Sbjct: 592 AGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 651

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
           G  + N     G TP+  A++  H +++ +LL +GA++ ++       LH A+      +
Sbjct: 652 G-AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
           A++L     D  A    G TPL +A        V   L +GAN   + K G T
Sbjct: 711 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 763



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 64/200 (32%), Positives = 100/200 (50%), Gaps = 2/200 (1%)

Query: 630 QKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLM 689
           QKV L+LL+    +  +  ++  TPLH AA+K  ++I   LL  GA  N V KQ  TPL 
Sbjct: 609 QKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 667

Query: 690 EAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDS 749
            A    H ++   ++ +G  ++   + G T LH AA+   + +  +L   G  D +A   
Sbjct: 668 LASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG-ADQDAHTK 726

Query: 750 GGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCD 809
            G+TP+I A  + +++++  LL +GA+V          LH A+  G   I  VLL     
Sbjct: 727 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786

Query: 810 LHAVNYHGDTPLHIAARESY 829
            +A   +G+T L IA R  Y
Sbjct: 787 PNATTANGNTALAIAKRLGY 806



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 72/253 (28%), Positives = 115/253 (45%), Gaps = 3/253 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++   G  +   L+L    +PN ++   +  TPLH A +K  +++  +L++ GA+I A
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARA--LNGFTPLHIACKKNRIKVMELLVKYGASIQA 426

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
           + +   TP+  A    HL +   ++Q G         G T LH AA+ G +E+V  LL  
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
           G + V+A+     TP+  A+     E++++LL   A            LH ++  G   +
Sbjct: 487 GAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
           A VLL A          G TPLH+AA+    D   L L R A  +   K G T   +   
Sbjct: 546 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 605

Query: 860 RSDVWFALQLNRK 872
             +   AL L  K
Sbjct: 606 YDNQKVALLLLEK 618



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 66/244 (27%), Positives = 118/244 (48%), Gaps = 3/244 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++   G +    L+L      +F +  ++  TPLH A+++G+  +  +LL  G  I+A
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTA--RNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             +   TPL  A  + H +V   +++RG  + ++ ++G + LH AA+  ++E V  LL  
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ- 353

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
            +  V+       T +  AA   H  V ++LL + A+           LH A       +
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 413

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
            E+L+     + A+   G TP+H+AA   + + VLL L  GA+P++ N  G+TA  +   
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473

Query: 860 RSDV 863
              V
Sbjct: 474 AGQV 477



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 46/140 (32%), Positives = 76/140 (54%), Gaps = 1/140 (0%)

Query: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
           K+ D +     AA+ GNL+ V   L  G +D+N  +  G   +  AA+  H+ +++ LL 
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLG 85

Query: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 832
           RG+ V     + N  LH AS  G A + +VL+    +++A + +G TPL++AA+E++ D 
Sbjct: 86  RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 145

Query: 833 VLLFLSRGANPELRNKEGDT 852
           V   L  GAN     ++G T
Sbjct: 146 VKYLLENGANQSTATEDGFT 165



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 65/249 (26%), Positives = 117/249 (46%), Gaps = 17/249 (6%)

Query: 623 SVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDK 682
           + + G L KV+  L   +D N  +  Q+    LH AA++G V +   LL  G+++++  K
Sbjct: 38  AARAGNLDKVVEYLKGGIDIN--TCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95

Query: 683 QQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV 742
           +  T L  A +    EV + +V+ G  + ++ ++G T L+ AA+  ++++V  LL  G  
Sbjct: 96  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155

Query: 743 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAE 801
              A + G +TP+  A +  H + + +LL        T  +  +  LH A+       A 
Sbjct: 156 QSTATEDG-FTPLAVALQQGHNQAVAILLEND-----TKGKVRLPALHIAARKDDTKSAA 209

Query: 802 VLLN--------ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
           +LL         ++  ++     G TPLHIAA     +   L L+RGA  +   + G T 
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269

Query: 854 WDLTPERSD 862
             +  +R +
Sbjct: 270 LHVASKRGN 278



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 48/161 (29%), Positives = 85/161 (52%), Gaps = 3/161 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+L+ ++G    V L+L  +   N     +S  T LH AAQ+  V +  +L + GA+ +A
Sbjct: 666 LHLASQEGHTDMVTLLL--DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             K   TPL+ A    ++++  +++++G  V +K ++G T LH AA+ G+  ++++LL  
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLT 780
           G    NA  + G T +  A    +I V+  L     +VT T
Sbjct: 784 G-AKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTT 823


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  108 bits (270), Expect = 3e-23
 Identities = 74/250 (29%), Positives = 127/250 (50%), Gaps = 3/250 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ K+  ++  ++ LL     + Q+  +S  TP+H AA  G + I  +LLQ GA+ + 
Sbjct: 402 LHIACKKNRIK--VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
            + +  T L  A     +EV R +++ G  V ++  +  T LH A+++G  E+V LLL  
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
                +A  + G+TP+  +A    ++V  +LL  GA  +L   +    LH A+  GS  +
Sbjct: 520 -MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
           A++LL  R    +   +G TPLH+AA        LL L +GA+P    K G T   +  +
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638

Query: 860 RSDVWFALQL 869
           ++ +  A  L
Sbjct: 639 KNQMQIASTL 648



 Score =  107 bits (268), Expect = 5e-23
 Identities = 74/244 (30%), Positives = 124/244 (50%), Gaps = 3/244 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ + G+++ V  +L +    + ++ ++  +TPLH A++ G  EI  +LLQ  A+ +A
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREE--QTPLHIASRLGKTEIVQLLLQHMAHPDA 525

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
                 TPL  +     ++VA  +++ G       + G T LH AAK G+L++  LLL  
Sbjct: 526 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
            +   ++    G TP+  AA + + +V  +LL +GA    T       LH A+      I
Sbjct: 586 -RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 644

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
           A  LLN   + + V   G TPLH+A++E + D V L L +GAN  +  K G T+  L  +
Sbjct: 645 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 704

Query: 860 RSDV 863
              V
Sbjct: 705 EDKV 708



 Score =  103 bits (257), Expect = 1e-21
 Identities = 80/267 (29%), Positives = 119/267 (44%), Gaps = 38/267 (14%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+L+ K+G +  V  +L      +  S  +   T LH A+  G  E+  VL++ GANINA
Sbjct: 68  LHLAAKEGHVGLVQELL--GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA 125

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             +   TPL  A   NH++V +Y+++ G    +  EDG T L  A + G+ + V++LL  
Sbjct: 126 QSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185

Query: 740 ------------------------------------GQVDVNAQDSGGWTPIIWAAEHKH 763
                                                ++ VN     G+TP+  AA + +
Sbjct: 186 DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 245

Query: 764 IEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 823
           + V  +LL RGA V  T       LH AS  G+  + ++LL+    + A    G TPLH 
Sbjct: 246 VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 305

Query: 824 AARESYHDCVLLFLSRGANPELRNKEG 850
           AAR  +   V L L RGA    R K G
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNG 332



 Score =  102 bits (254), Expect = 2e-21
 Identities = 73/200 (36%), Positives = 96/200 (48%), Gaps = 1/200 (0%)

Query: 653 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 712
           T LH AA  G   +  +LL   AN NA      TPL  A   N ++V   +V+ G  + +
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426

Query: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
             E G T +H AA +G+L +V LLL  G    +  +  G T +  AA    +EV+R LL 
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLR 485

Query: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 832
            GA V     EE   LH AS  G   I ++LL       A   +G TPLHI+ARE   D 
Sbjct: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545

Query: 833 VLLFLSRGANPELRNKEGDT 852
             + L  GA   L  K+G T
Sbjct: 546 ASVLLEAGAAHSLATKKGFT 565



 Score =  102 bits (253), Expect = 3e-21
 Identities = 71/233 (30%), Positives = 118/233 (50%), Gaps = 3/233 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++ + G+ + V L+L     P+  +   +  TPLH +A++G V++  VLL+AGA  + 
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATT--NGYTPLHISAREGQVDVASVLLEAGAAHSL 558

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             K+  TPL  A     L+VA+ ++QR     S  ++G T LH AA   N ++  LLL  
Sbjct: 559 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 618

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
           G    +A    G+TP+  AA+   +++   LL  GA+  +   +    LH AS  G   +
Sbjct: 619 G-ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 677

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
             +LL+   ++H     G T LH+AA+E   +   +    GA+ +   K G T
Sbjct: 678 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 65/233 (27%), Positives = 118/233 (50%), Gaps = 3/233 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L++S ++G++    ++L      +  + +    TPLH AA+ GS+++  +LLQ  A  ++
Sbjct: 534 LHISAREGQVDVASVLLEAGAAHSLATKKGF--TPLHVAAKYGSLDVAKLLLQRRAAADS 591

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             K   TPL  A   ++ +VA  ++++G   ++  ++G T LH AAK   +++ S LL+ 
Sbjct: 592 AGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 651

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
           G  + N     G TP+  A++  H +++ +LL +GA++ ++       LH A+      +
Sbjct: 652 G-AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
           A++L     D  A    G TPL +A        V   L +GAN   + K G T
Sbjct: 711 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 763



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 64/200 (32%), Positives = 100/200 (50%), Gaps = 2/200 (1%)

Query: 630 QKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLM 689
           QKV L+LL+    +  +  ++  TPLH AA+K  ++I   LL  GA  N V KQ  TPL 
Sbjct: 609 QKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 667

Query: 690 EAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDS 749
            A    H ++   ++ +G  ++   + G T LH AA+   + +  +L   G  D +A   
Sbjct: 668 LASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG-ADQDAHTK 726

Query: 750 GGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCD 809
            G+TP+I A  + +++++  LL +GA+V          LH A+  G   I  VLL     
Sbjct: 727 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786

Query: 810 LHAVNYHGDTPLHIAARESY 829
            +A   +G+T L IA R  Y
Sbjct: 787 PNATTANGNTALAIAKRLGY 806



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 72/253 (28%), Positives = 115/253 (45%), Gaps = 3/253 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++   G  +   L+L    +PN ++   +  TPLH A +K  +++  +L++ GA+I A
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARA--LNGFTPLHIACKKNRIKVMELLVKYGASIQA 426

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
           + +   TP+  A    HL +   ++Q G         G T LH AA+ G +E+V  LL  
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
           G + V+A+     TP+  A+     E++++LL   A            LH ++  G   +
Sbjct: 487 GAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
           A VLL A          G TPLH+AA+    D   L L R A  +   K G T   +   
Sbjct: 546 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 605

Query: 860 RSDVWFALQLNRK 872
             +   AL L  K
Sbjct: 606 YDNQKVALLLLEK 618



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 66/244 (27%), Positives = 118/244 (48%), Gaps = 3/244 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+++   G +    L+L      +F +  ++  TPLH A+++G+  +  +LL  G  I+A
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTA--RNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             +   TPL  A  + H +V   +++RG  + ++ ++G + LH AA+  ++E V  LL  
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ- 353

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 799
            +  V+       T +  AA   H  V ++LL + A+           LH A       +
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 413

Query: 800 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
            E+L+     + A+   G TP+H+AA   + + VLL L  GA+P++ N  G+TA  +   
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473

Query: 860 RSDV 863
              V
Sbjct: 474 AGQV 477



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 46/140 (32%), Positives = 76/140 (54%), Gaps = 1/140 (0%)

Query: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
           K+ D +     AA+ GNL+ V   L  G +D+N  +  G   +  AA+  H+ +++ LL 
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLG 85

Query: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 832
           RG+ V     + N  LH AS  G A + +VL+    +++A + +G TPL++AA+E++ D 
Sbjct: 86  RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 145

Query: 833 VLLFLSRGANPELRNKEGDT 852
           V   L  GAN     ++G T
Sbjct: 146 VKYLLENGANQSTATEDGFT 165



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 65/249 (26%), Positives = 117/249 (46%), Gaps = 17/249 (6%)

Query: 623 SVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDK 682
           + + G L KV+  L   +D N  +  Q+    LH AA++G V +   LL  G+++++  K
Sbjct: 38  AARAGNLDKVVEYLKGGIDIN--TCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95

Query: 683 QQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV 742
           +  T L  A +    EV + +V+ G  + ++ ++G T L+ AA+  ++++V  LL  G  
Sbjct: 96  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155

Query: 743 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAE 801
              A + G +TP+  A +  H + + +LL        T  +  +  LH A+       A 
Sbjct: 156 QSTATEDG-FTPLAVALQQGHNQAVAILLEND-----TKGKVRLPALHIAARKDDTKSAA 209

Query: 802 VLLN--------ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
           +LL         ++  ++     G TPLHIAA     +   L L+RGA  +   + G T 
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269

Query: 854 WDLTPERSD 862
             +  +R +
Sbjct: 270 LHVASKRGN 278



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 48/161 (29%), Positives = 85/161 (52%), Gaps = 3/161 (1%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+L+ ++G    V L+L  +   N     +S  T LH AAQ+  V +  +L + GA+ +A
Sbjct: 666 LHLASQEGHTDMVTLLL--DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723

Query: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
             K   TPL+ A    ++++  +++++G  V +K ++G T LH AA+ G+  ++++LL  
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783

Query: 740 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLT 780
           G    NA  + G T +  A    +I V+  L     +VT T
Sbjct: 784 G-AKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTT 823



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 64/316 (20%), Positives = 107/316 (33%), Gaps = 25/316 (7%)

Query: 38   HGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLE 97
            H  +  + ++E   P ++    E   P SP++ T         +PV +T        +  
Sbjct: 1854 HSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTER------HSPVSSTKTERHPPVSPS 1907

Query: 98   GDGDLRGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGA 157
            G  D R      G   K  P SP   G    R  +S +G       V +       +P +
Sbjct: 1908 GKTDKRPPVSPSGRTEKHPPVSP---GRTEKRLPVSPSGRTDKHQPVSTAGKTEKHLPVS 1964

Query: 158  QGAAAAGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSL 217
                     P   T+  E   +    R+ M    +GQ P   K                 
Sbjct: 1965 PSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQEK 2024

Query: 218  GKVTSDLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSY 277
            GKV  +  K   L        E  + +R   + +T    G+ E    V          S 
Sbjct: 2025 GKVRVEKEKGPILTQREAQKTENQTIKRGQRLPVT----GTAESKRGV-------RVSSI 2073

Query: 278  SVDERVDSDSKSEVEALTEQLSEEEE---EEEEEEEEEEEEEEEEEEEEDEESGNQSDRS 334
             V +   +  K +V  L+ ++ E  +   EEE   E E  +E+  +E+ D +     DR 
Sbjct: 2074 GVKKEDAAGGKEKV--LSHKIPEPVQSVPEEESHRESEVPKEKMADEQGDMDLQISPDRK 2131

Query: 335  GSSGRRKAKKKWRKDS 350
             S+   +  K+  +D+
Sbjct: 2132 TSTDFSEVIKQELEDN 2147


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  107 bits (267), Expect = 7e-23
 Identities = 80/259 (30%), Positives = 122/259 (47%), Gaps = 34/259 (13%)

Query: 615 FHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 674
           F    L L+  +G L+ V  +L    D   ++D+    T L  A   G VE+  +LL +G
Sbjct: 400 FKESALTLACYKGHLEMVRFLLEAGADQEHKTDEM--HTALMEACMDGHVEVARLLLDSG 457

Query: 675 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVS 734
           A +N       +PL  A    H+E+A  +++RG  +    ++G T L  AA+ G+ EMV+
Sbjct: 458 AQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA 517

Query: 735 LLLSTGQVDVNAQDS------------GGW-------------------TPIIWAAEHKH 763
           LLL  G  ++NAQ              GG+                   TP++ AA+  H
Sbjct: 518 LLLGQG-ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGH 576

Query: 764 IEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 823
           +E+++ LL  GA+V  T    +  L +A   G   +A+VLL A  DL   +  G TPL  
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636

Query: 824 AARESYHDCVLLFLSRGAN 842
           AAR  +   V   +S+GAN
Sbjct: 637 AARAGHVCTVQFLISKGAN 655



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 70/224 (31%), Positives = 111/224 (49%), Gaps = 5/224 (2%)

Query: 631 KVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLME 690
           +V  +LL+N         + K + L  A  KG +E+   LL+AGA+      +  T LME
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440

Query: 691 AVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 750
           A ++ H+EVAR ++  G  V    +   + L  AA  G++E+ +LL+  G       D G
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEG 500

Query: 751 GWTPIIWAAEHKHIEVIRMLLTRGADVTL-TDNEENICLHWASFTGSAAIAEVLLNARCD 809
            +TP++ AA   H E++ +LL +GA++   T+  +   L  A   G   +A+ L+ A  D
Sbjct: 501 -YTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGAD 559

Query: 810 LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
              +     TPL  AA+E + + V   L+ GAN       GDTA
Sbjct: 560 ---IELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 101/339 (29%), Positives = 152/339 (44%), Gaps = 30/339 (8%)

Query: 521  TPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPN 580
            TP    AA    P     P  +    PSA +     P  P  D  A T  +   +LTL  
Sbjct: 1040 TPTHSIAASISQP---QTPTPSPIISPSAML-----PIYPAIDIDAQTESNHDTALTLAC 1091

Query: 581  GGCLSAVGLPLGPGREALEKALVIQES--ERRKKLRFHPRQLYLSVKQGELQKVILMLLD 638
             G           G E L + L+ + +  E R K  F P  L L+   G +  V ++L +
Sbjct: 1092 AG-----------GHEELVQTLLERGASIEHRDKKGFTP--LILAATAGHVGVVEILLDN 1138

Query: 639  NLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLE 698
              D   QS++ +K TPL  A   G  E+  +LL  GAN    +    TPL  A    ++ 
Sbjct: 1139 GADIEAQSER-TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVN 1197

Query: 699  VARYMVQRGGCVYSK--EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQ-DSGGWTPI 755
            + + ++  G  + S+   + G + L  AA  G+   V LLL  G  D+NAQ ++   T +
Sbjct: 1198 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS-DINAQIETNRNTAL 1256

Query: 756  IWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHA--V 813
              A      EV+ +LL R A+V          L  A+  G A +  VLL+   D++A  V
Sbjct: 1257 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1316

Query: 814  NYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
                DT L IAA + ++    L + RGA+ ++RNK+G+T
Sbjct: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNT 1355



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 80/257 (31%), Positives = 114/257 (44%), Gaps = 40/257 (15%)

Query: 628 ELQKVILMLLDNL-DPNFQSDQQSKRTPLHAAAQKGS----------------------- 663
           EL +V+L +  N+ D   + D     TPL AAA  G                        
Sbjct: 281 ELAQVLLAMHANVEDRGIKGDI----TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNT 336

Query: 664 ----------VEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRG-GCVYS 712
                     V++  VLL++GA+I   ++   TPLMEA    H+EVAR +++ G G    
Sbjct: 337 ALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH 396

Query: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
             E   + L  A   G+LEMV  LL  G  D   +     T ++ A    H+EV R+LL 
Sbjct: 397 SNEFKESALTLACYKGHLEMVRFLLEAG-ADQEHKTDEMHTALMEACMDGHVEVARLLLD 455

Query: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 832
            GA V +  +     L  A+  G   +A +L+     L  VN  G TPL  AARE + + 
Sbjct: 456 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM 515

Query: 833 VLLFLSRGANPELRNKE 849
           V L L +GAN   + +E
Sbjct: 516 VALLLGQGANINAQTEE 532



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 73/221 (33%), Positives = 109/221 (49%), Gaps = 7/221 (3%)

Query: 627  GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAV--DKQQ 684
            G  Q+V+ +LL     N +    S  TPL  AA  G V I  +LL AGA IN+    K  
Sbjct: 1160 GGRQEVVELLLAR-GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1218

Query: 685  RTPLMEAVVNNHLEVARYMVQRGGCVYSK-EEDGSTCLHHAAKIGNLEMVSLLLSTGQVD 743
             +PLM A +N H    + ++  G  + ++ E + +T L  A   G  E+VSLLL   + +
Sbjct: 1219 ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDR-KAN 1277

Query: 744  VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTL--TDNEENICLHWASFTGSAAIAE 801
            V  +   G TP++ AA   + EV R+LL +GADV      +  +  L  A+  G     E
Sbjct: 1278 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1337

Query: 802  VLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGAN 842
            +L+     +   N  G+TPL +AA   + D V L +  GA+
Sbjct: 1338 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1378



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 66/227 (29%), Positives = 102/227 (44%), Gaps = 14/227 (6%)

Query: 580  NGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDN 639
            +GG ++ + + L  G E          S    KL   P  L L+   G    V L+L   
Sbjct: 1192 SGGYVNIIKILLNAGAEI--------NSRTGSKLGISP--LMLAAMNGHTAAVKLLLDMG 1241

Query: 640  LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEV 699
             D N Q +  ++ T L  A  +G  E+  +LL   AN+    K   TPLMEA    + EV
Sbjct: 1242 SDINAQIET-NRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1300

Query: 700  ARYMVQRGGCVYSKEEDGS--TCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 757
             R ++ +G  V +     S  T L  AA  G+ +   LL+  G   ++ ++  G TP+  
Sbjct: 1301 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRG-AHIDVRNKKGNTPLWL 1359

Query: 758  AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLL 804
            AA   H++V+++L+  GADV   DN +   L  A   G   +   L+
Sbjct: 1360 AANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 50/153 (32%), Positives = 75/153 (49%)

Query: 653 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 712
           TPL  AAQ+G +E+   LL AGAN++A      T L  A  N H +VA  ++Q G  +  
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625

Query: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
           + E G T L  AA+ G++  V  L+S G        +   T +  A    H+ V+ +LL 
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685

Query: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLN 805
            GAD T    + +  L  A+  G  ++   LL+
Sbjct: 686 HGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 29/81 (35%), Positives = 49/81 (60%), Gaps = 4/81 (4%)

Query: 653  TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 712
            TPL  AA  G +++  +L+QAGA+++A D ++ TPLM A    H++V RY+V+      +
Sbjct: 1355 TPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE----VN 1410

Query: 713  KEEDGSTCLHHAAKIGNLEMV 733
            +    S C+ + A I + EM+
Sbjct: 1411 QFPSDSECMRYIATITDKEML 1431



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 32/96 (33%), Positives = 45/96 (46%), Gaps = 1/96 (1%)

Query: 643 NFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN-AVDKQQRTPLMEAVVNNHLEVAR 701
           + + + +  RTPL  AA+ G V     L+  GAN+N        T L  A    HL V  
Sbjct: 622 DLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVE 681

Query: 702 YMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 737
            ++  G     + +DGST L  AAK G+  +V  LL
Sbjct: 682 LLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717



 Score = 34.7 bits (78), Expect = 0.55
 Identities = 28/97 (28%), Positives = 40/97 (41%), Gaps = 1/97 (1%)

Query: 758 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 817
           A     +  +R LL  G  V     E    L  A   G   +A+VLL    ++      G
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300

Query: 818 D-TPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
           D TPL  AA   +   V L L+  A+   ++  G+TA
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTA 337



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 44/199 (22%), Positives = 73/199 (36%), Gaps = 27/199 (13%)

Query: 28   KETRGATERVHGSLGDTPRSEETLPKAT-PDSLEPAGPSSPAS-----VTVTVGDEGADT 81
            + + G+     GSL  +P +  +   +T P +     PSSP+      VTV        T
Sbjct: 1952 QNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTT 2011

Query: 82   PVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSPSK---------------GGSC 126
             V  T      + N               H   S PSSPS                G + 
Sbjct: 2012 TVTTTA----SNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSAS 2067

Query: 127  PSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGS--EPPPATTSPEGQPKVHRAR 184
            P++   S      SPP V++   R  +   + G+++A S  + PP + S E +P + +++
Sbjct: 2068 PNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQ 2127

Query: 185  KTMSKPGNGQPPVPEKRPP 203
                +     PP+     P
Sbjct: 2128 VPPPEVRMTVPPLATSSAP 2146


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
           sapiens]
          Length = 2352

 Score =  107 bits (267), Expect = 7e-23
 Identities = 80/259 (30%), Positives = 122/259 (47%), Gaps = 34/259 (13%)

Query: 615 FHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 674
           F    L L+  +G L+ V  +L    D   ++D+    T L  A   G VE+  +LL +G
Sbjct: 400 FKESALTLACYKGHLEMVRFLLEAGADQEHKTDEM--HTALMEACMDGHVEVARLLLDSG 457

Query: 675 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVS 734
           A +N       +PL  A    H+E+A  +++RG  +    ++G T L  AA+ G+ EMV+
Sbjct: 458 AQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA 517

Query: 735 LLLSTGQVDVNAQDS------------GGW-------------------TPIIWAAEHKH 763
           LLL  G  ++NAQ              GG+                   TP++ AA+  H
Sbjct: 518 LLLGQG-ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGH 576

Query: 764 IEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 823
           +E+++ LL  GA+V  T    +  L +A   G   +A+VLL A  DL   +  G TPL  
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636

Query: 824 AARESYHDCVLLFLSRGAN 842
           AAR  +   V   +S+GAN
Sbjct: 637 AARAGHVCTVQFLISKGAN 655



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 70/224 (31%), Positives = 111/224 (49%), Gaps = 5/224 (2%)

Query: 631 KVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLME 690
           +V  +LL+N         + K + L  A  KG +E+   LL+AGA+      +  T LME
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440

Query: 691 AVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 750
           A ++ H+EVAR ++  G  V    +   + L  AA  G++E+ +LL+  G       D G
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEG 500

Query: 751 GWTPIIWAAEHKHIEVIRMLLTRGADVTL-TDNEENICLHWASFTGSAAIAEVLLNARCD 809
            +TP++ AA   H E++ +LL +GA++   T+  +   L  A   G   +A+ L+ A  D
Sbjct: 501 -YTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGAD 559

Query: 810 LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
              +     TPL  AA+E + + V   L+ GAN       GDTA
Sbjct: 560 ---IELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 104/366 (28%), Positives = 167/366 (45%), Gaps = 32/366 (8%)

Query: 508  EAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRAD--TSQPSARMRGH-GEPRRPPCDP 564
            +A  + +P  +   PPA  A   P   ++ V GRA   ++ P+  +     +P+ P   P
Sbjct: 750  QALPMVVPPQEPDKPPANVATTLPIR-NKAVSGRASAMSNTPTHSIAASISQPQTPTPSP 808

Query: 565  LADTIDSSGPSLTLPNGGCL-----------SAVGLPLGPGREALEKALVIQES--ERRK 611
            +        PS  LP    +           +A+ L    G E L + L+ + +  E R 
Sbjct: 809  IIS------PSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRD 862

Query: 612  KLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLL 671
            K  F P  L L+   G +  V ++L +  D   QS++ +K TPL  A   G  E+  +LL
Sbjct: 863  KKGFTP--LILAATAGHVGVVEILLDNGADIEAQSER-TKDTPLSLACSGGRQEVVELLL 919

Query: 672  QAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK--EEDGSTCLHHAAKIGN 729
              GAN    +    TPL  A    ++ + + ++  G  + S+   + G + L  AA  G+
Sbjct: 920  ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 979

Query: 730  LEMVSLLLSTGQVDVNAQ-DSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICL 788
               V LLL  G  D+NAQ ++   T +  A      EV+ +LL R A+V          L
Sbjct: 980  TAAVKLLLDMGS-DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPL 1038

Query: 789  HWASFTGSAAIAEVLLNARCDLHA--VNYHGDTPLHIAARESYHDCVLLFLSRGANPELR 846
              A+  G A +  VLL+   D++A  V    DT L IAA + ++    L + RGA+ ++R
Sbjct: 1039 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR 1098

Query: 847  NKEGDT 852
            NK+G+T
Sbjct: 1099 NKKGNT 1104



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 80/257 (31%), Positives = 114/257 (44%), Gaps = 40/257 (15%)

Query: 628 ELQKVILMLLDNL-DPNFQSDQQSKRTPLHAAAQKGS----------------------- 663
           EL +V+L +  N+ D   + D     TPL AAA  G                        
Sbjct: 281 ELAQVLLAMHANVEDRGIKGDI----TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNT 336

Query: 664 ----------VEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRG-GCVYS 712
                     V++  VLL++GA+I   ++   TPLMEA    H+EVAR +++ G G    
Sbjct: 337 ALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH 396

Query: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
             E   + L  A   G+LEMV  LL  G  D   +     T ++ A    H+EV R+LL 
Sbjct: 397 SNEFKESALTLACYKGHLEMVRFLLEAG-ADQEHKTDEMHTALMEACMDGHVEVARLLLD 455

Query: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 832
            GA V +  +     L  A+  G   +A +L+     L  VN  G TPL  AARE + + 
Sbjct: 456 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM 515

Query: 833 VLLFLSRGANPELRNKE 849
           V L L +GAN   + +E
Sbjct: 516 VALLLGQGANINAQTEE 532



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 73/221 (33%), Positives = 109/221 (49%), Gaps = 7/221 (3%)

Query: 627  GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAV--DKQQ 684
            G  Q+V+ +LL     N +    S  TPL  AA  G V I  +LL AGA IN+    K  
Sbjct: 909  GGRQEVVELLLAR-GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 967

Query: 685  RTPLMEAVVNNHLEVARYMVQRGGCVYSK-EEDGSTCLHHAAKIGNLEMVSLLLSTGQVD 743
             +PLM A +N H    + ++  G  + ++ E + +T L  A   G  E+VSLLL   + +
Sbjct: 968  ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDR-KAN 1026

Query: 744  VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTL--TDNEENICLHWASFTGSAAIAE 801
            V  +   G TP++ AA   + EV R+LL +GADV      +  +  L  A+  G     E
Sbjct: 1027 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1086

Query: 802  VLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGAN 842
            +L+     +   N  G+TPL +AA   + D V L +  GA+
Sbjct: 1087 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1127



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 66/227 (29%), Positives = 102/227 (44%), Gaps = 14/227 (6%)

Query: 580  NGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDN 639
            +GG ++ + + L  G E          S    KL   P  L L+   G    V L+L   
Sbjct: 941  SGGYVNIIKILLNAGAEI--------NSRTGSKLGISP--LMLAAMNGHTAAVKLLLDMG 990

Query: 640  LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEV 699
             D N Q +  ++ T L  A  +G  E+  +LL   AN+    K   TPLMEA    + EV
Sbjct: 991  SDINAQIET-NRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1049

Query: 700  ARYMVQRGGCVYSKEEDGS--TCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 757
             R ++ +G  V +     S  T L  AA  G+ +   LL+  G   ++ ++  G TP+  
Sbjct: 1050 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRG-AHIDVRNKKGNTPLWL 1108

Query: 758  AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLL 804
            AA   H++V+++L+  GADV   DN +   L  A   G   +   L+
Sbjct: 1109 AANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 50/153 (32%), Positives = 75/153 (49%)

Query: 653 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 712
           TPL  AAQ+G +E+   LL AGAN++A      T L  A  N H +VA  ++Q G  +  
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625

Query: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
           + E G T L  AA+ G++  V  L+S G        +   T +  A    H+ V+ +LL 
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685

Query: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLN 805
            GAD T    + +  L  A+  G  ++   LL+
Sbjct: 686 HGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 29/81 (35%), Positives = 49/81 (60%), Gaps = 4/81 (4%)

Query: 653  TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 712
            TPL  AA  G +++  +L+QAGA+++A D ++ TPLM A    H++V RY+V+      +
Sbjct: 1104 TPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE----VN 1159

Query: 713  KEEDGSTCLHHAAKIGNLEMV 733
            +    S C+ + A I + EM+
Sbjct: 1160 QFPSDSECMRYIATITDKEML 1180



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 32/96 (33%), Positives = 45/96 (46%), Gaps = 1/96 (1%)

Query: 643 NFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN-AVDKQQRTPLMEAVVNNHLEVAR 701
           + + + +  RTPL  AA+ G V     L+  GAN+N        T L  A    HL V  
Sbjct: 622 DLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVE 681

Query: 702 YMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 737
            ++  G     + +DGST L  AAK G+  +V  LL
Sbjct: 682 LLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717



 Score = 34.7 bits (78), Expect = 0.55
 Identities = 28/97 (28%), Positives = 40/97 (41%), Gaps = 1/97 (1%)

Query: 758 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 817
           A     +  +R LL  G  V     E    L  A   G   +A+VLL    ++      G
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300

Query: 818 D-TPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
           D TPL  AA   +   V L L+  A+   ++  G+TA
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTA 337



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 44/199 (22%), Positives = 73/199 (36%), Gaps = 27/199 (13%)

Query: 28   KETRGATERVHGSLGDTPRSEETLPKAT-PDSLEPAGPSSPAS-----VTVTVGDEGADT 81
            + + G+     GSL  +P +  +   +T P +     PSSP+      VTV        T
Sbjct: 1701 QNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTT 1760

Query: 82   PVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSPSK---------------GGSC 126
             V  T      + N               H   S PSSPS                G + 
Sbjct: 1761 TVTTTA----SNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSAS 1816

Query: 127  PSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGS--EPPPATTSPEGQPKVHRAR 184
            P++   S      SPP V++   R  +   + G+++A S  + PP + S E +P + +++
Sbjct: 1817 PNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQ 1876

Query: 185  KTMSKPGNGQPPVPEKRPP 203
                +     PP+     P
Sbjct: 1877 VPPPEVRMTVPPLATSSAP 1895


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  107 bits (266), Expect = 9e-23
 Identities = 73/237 (30%), Positives = 110/237 (46%), Gaps = 34/237 (14%)

Query: 649 QSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGG 708
           Q +RTPLHAAA  G V I  +LL +GAN+NA D    TPL  A  + + +V   ++    
Sbjct: 39  QERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSA 98

Query: 709 CVYSKEE---------------------------------DGSTCLHHAAKIGNLEMVSL 735
            V ++++                                  G + LHHA   G+LE V+L
Sbjct: 99  DVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNL 158

Query: 736 LLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTG 795
           LL+ G   +N  D     P+ WAA   H+EV+++L+ RGAD+   D +    LH A+ +G
Sbjct: 159 LLNKG-ASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASG 217

Query: 796 SAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
              + + LL    ++   N  G+T LHIA         +  ++ GAN    N +G T
Sbjct: 218 QIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFT 274



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 65/231 (28%), Positives = 103/231 (44%), Gaps = 33/231 (14%)

Query: 649 QSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGG 708
           +S R+ LH A   G +E  ++LL  GA++N  DK++R PL  A    HLEV + +V RG 
Sbjct: 138 RSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGA 197

Query: 709 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQ--------------------------- 741
            +  K+  G   LH AA  G +E+V  LL  G                            
Sbjct: 198 DLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIE 257

Query: 742 -----VDVNAQDSGGWTPI-IWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTG 795
                 +VN  +  G+TP+ + A        + +L+  GADV     E    LH A+  G
Sbjct: 258 LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHG 317

Query: 796 SAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELR 846
               +++L+    ++   +  G+TPLH+AAR  +   +   ++ GA+   R
Sbjct: 318 RFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARR 368



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 74/228 (32%), Positives = 105/228 (46%), Gaps = 8/228 (3%)

Query: 631 KVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLME 690
           + +L    + DP       S  +P+H A+  G  E C  LL   +  + ++    TPL  
Sbjct: 771 RTLLQAALSTDPLDAGVDYSGYSPMHWASYTGH-EDCLELLLEHSPFSYLEGNPFTPLHC 829

Query: 691 AVVNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQD 748
           AV+NN       ++   G   V S++  G T LH AA   N+  + +LL   Q +VNA D
Sbjct: 830 AVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQH-QAEVNATD 888

Query: 749 SGGWTPIIWAAEHKHIEVIRMLLTRG-ADVTLTDNEENICLHWASFTGSAAIAEVLLNAR 807
             G T ++ AAE+     +  LL RG AD+T+ D  +N  LH A   G    A ++L   
Sbjct: 889 HTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAET 948

Query: 808 CDLHAVNYHGDT---PLHIAARESYHDCVLLFLSRGANPELRNKEGDT 852
            DL  +N        PLHIAAR      V   LS GA     ++EG T
Sbjct: 949 QDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHT 996



 Score = 84.7 bits (208), Expect = 5e-16
 Identities = 67/233 (28%), Positives = 102/233 (43%), Gaps = 34/233 (14%)

Query: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 713
           PL  A     VE    LL    NIN +D+++RTPL  A     + + + ++  G  V +K
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70

Query: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHK----------- 762
           +    T LH AA   N +++ LLL+    DVNA+D    TP+  AA ++           
Sbjct: 71  DTLWLTPLHRAAASRNEKVLGLLLA-HSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129

Query: 763 ----------------------HIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIA 800
                                 H+E + +LL +GA + + D +E   LHWA+F G   + 
Sbjct: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL 189

Query: 801 EVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
           ++L+    DL   +  G   LH AA     + V   L  GA  +  N  G+TA
Sbjct: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTA 242



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 73/265 (27%), Positives = 112/265 (42%), Gaps = 47/265 (17%)

Query: 634 LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVV 693
           L++ +  D N+QS +   ++PLH AA  G      +L+Q G+ I+  DK   TPL  A  
Sbjct: 291 LLVNNGADVNYQSKEG--KSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAAR 348

Query: 694 NNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV----------- 742
             H  +   ++  G     +       LH A   G  +    LLS+GQ+           
Sbjct: 349 YGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEH 408

Query: 743 ------DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGS 796
                 D+N  D+ G T +  AA   ++E + +LL+ GAD+   D      LH+A+  GS
Sbjct: 409 VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468

Query: 797 AAIAEVLLNARCDLHAVNYHGDTPLHIAARE-----------SYHD-------------- 831
              A  L+ A   ++  +  G +PLH AA             S HD              
Sbjct: 469 YQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKE 528

Query: 832 ---CVLLFLSRGANPELRNKEGDTA 853
              C+   L  GA+P LR+++G TA
Sbjct: 529 AFFCLEFLLDNGADPSLRDRQGYTA 553



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 60/231 (25%), Positives = 102/231 (44%), Gaps = 20/231 (8%)

Query: 630 QKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEIC-HVLLQAGANINAVDKQQRTPL 688
           Q  + + L N   N         TPLH AA   +  +C  +L+  GA++N   K+ ++PL
Sbjct: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310

Query: 689 MEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQD 748
             A ++     ++ ++Q G  +   ++ G+T LH AA+ G+  ++S L++ G  D   + 
Sbjct: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNG-ADTARRG 369

Query: 749 SGGWTPIIWAAEHKHIEVIRMLLTRGA------------------DVTLTDNEENICLHW 790
                P+  A      +  R LL+ G                   D+   DN    CLH 
Sbjct: 370 IHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHA 429

Query: 791 ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA 841
           A+  G+     +LL++  DL   +  G TPLH AA    + C +  ++ GA
Sbjct: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 60/212 (28%), Positives = 100/212 (47%), Gaps = 10/212 (4%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGAN--- 676
           L+L+ ++G  + V ++         + +++ K TPLHAAA  G  +  H+L+ +G     
Sbjct: 622 LFLATERGSTECVEVLTAHGASALIK-ERKRKWTPLHAAAASGHTDSLHLLIDSGERADI 680

Query: 677 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 736
            + +D   +TPLM A++N H++    ++++G    + +  G T LH  A  G  + ++ L
Sbjct: 681 TDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAAL 740

Query: 737 LSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC----LHWAS 792
           L      V  +D  G TPI  A+   H  V+R LL         D   +      +HWAS
Sbjct: 741 LD-HDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWAS 799

Query: 793 FTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 824
           +TG     E+LL        +  +  TPLH A
Sbjct: 800 YTGHEDCLELLLE-HSPFSYLEGNPFTPLHCA 830



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 70/252 (27%), Positives = 108/252 (42%), Gaps = 22/252 (8%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+ +   G+++ V  +L   +            T LH A   G   +   L+ AGAN+N 
Sbjct: 210 LHTAAASGQIEVVKYLL--RMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQ 267

Query: 680 VDKQQRTPL-MEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 738
            + +  TPL + AV  N       +V  G  V  + ++G + LH AA  G      +L+ 
Sbjct: 268 PNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQ 327

Query: 739 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTG--- 795
            G  +++  D  G TP+  AA + H  +I  L+T GAD       +   LH A   G   
Sbjct: 328 NGS-EIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSD 386

Query: 796 ---------------SAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRG 840
                          S+   E +L+A  D++  +  G T LH AA     +C+ L LS G
Sbjct: 387 CCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSG 446

Query: 841 ANPELRNKEGDT 852
           A+   R+K G T
Sbjct: 447 ADLRRRDKFGRT 458



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 54/192 (28%), Positives = 87/192 (45%), Gaps = 4/192 (2%)

Query: 653 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 712
           +PLH AA  G  E    L +   N++  D + RT L  A      E    +   G     
Sbjct: 587 SPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALI 646

Query: 713 KEEDGS-TCLHHAAKIGNLEMVSLLLSTGQ-VDV-NAQDSGGWTPIIWAAEHKHIEVIRM 769
           KE     T LH AA  G+ + + LL+ +G+  D+ +  D+ G TP++ A  + H++ + +
Sbjct: 647 KERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHL 706

Query: 770 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 829
           LL +G+     D      LH  + TG       LL+    +   ++ G TP+H+A+    
Sbjct: 707 LLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLAS-ACG 765

Query: 830 HDCVLLFLSRGA 841
           H  VL  L + A
Sbjct: 766 HTAVLRTLLQAA 777



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 60/211 (28%), Positives = 96/211 (45%), Gaps = 8/211 (3%)

Query: 652 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 711
           RT LHAAA  G+VE  ++LL +GA++   DK  RTPL  A  N   + A  +V  G  V 
Sbjct: 424 RTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVN 483

Query: 712 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL 771
             +  G + LH+AA                   ++ D+    P+  +   +    +  LL
Sbjct: 484 EADCKGCSPLHYAAASDTYRRAE------PHTPSSHDAEEDEPLKESRRKEAFFCLEFLL 537

Query: 772 TRGADVTLTDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGDTPLHIAARESY 829
             GAD +L D +    +H+A+  G+    E+LL  +  C     +    +PLH+AA   +
Sbjct: 538 DNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGH 597

Query: 830 HDCVLLFLSRGANPELRNKEGDTAWDLTPER 860
            + +        N ++R+ +G TA  L  ER
Sbjct: 598 CEALKTLAETLVNLDVRDHKGRTALFLATER 628



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 58/194 (29%), Positives = 93/194 (47%), Gaps = 9/194 (4%)

Query: 652 RTPLHAAAQKGSVEICHVLLQAGANIN----AVDKQQRTPLMEAVVNNHLEVARYMVQRG 707
           RTP+H A+  G   +   LLQA  + +     VD    +P+  A    H +    +++  
Sbjct: 755 RTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHS 814

Query: 708 GCVYSKEEDGSTCLHHAAKIGNLEMVS--LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 765
              Y  E +  T LH  A I N +  +  LL + G   VN++D+ G TP+  AA   ++ 
Sbjct: 815 PFSYL-EGNPFTPLH-CAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVS 872

Query: 766 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLL-NARCDLHAVNYHGDTPLHIA 824
            +RMLL   A+V  TD+     L  A+  G  A  E LL   + DL  ++ + +T LH+A
Sbjct: 873 GLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLA 932

Query: 825 ARESYHDCVLLFLS 838
             + +  C L+ L+
Sbjct: 933 CSKGHEKCALMILA 946



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 67/300 (22%), Positives = 116/300 (38%), Gaps = 68/300 (22%)

Query: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
           L+ +   G ++ + L+L    D   +   +  RTPLH AA  GS +    L+ AGA +N 
Sbjct: 427 LHAAASGGNVECLNLLLSSGAD--LRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE 484

Query: 680 VDKQQRTPLMEAVVNNHLEVAR----------------------------YMVQRGGCVY 711
            D +  +PL  A  ++    A                             +++  G    
Sbjct: 485 ADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544

Query: 712 SKEEDGSTCLHHAAKIGNLEMVSLLLSTG------------------------------- 740
            ++  G T +H+AA  GN + + LLL                                  
Sbjct: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTL 604

Query: 741 ---QVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC-LHWASFTGS 796
               V+++ +D  G T +  A E    E + +L   GA   + + +     LH A+ +G 
Sbjct: 605 AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGH 664

Query: 797 AAIAEVLLNA--RCDLHAV-NYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 853
                +L+++  R D+  V + +G TPL +A    + DCV L L +G+  +  +  G TA
Sbjct: 665 TDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTA 724



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 64/228 (28%), Positives = 97/228 (42%), Gaps = 15/228 (6%)

Query: 620 LYLSVKQG--ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANI 677
           L+L+   G  E  K +   L NLD          RT L  A ++GS E   VL   GA+ 
Sbjct: 589 LHLAAYNGHCEALKTLAETLVNLDVR----DHKGRTALFLATERGSTECVEVLTAHGASA 644

Query: 678 NAVDKQQR-TPLMEAVVNNHLEVARYMV---QRGGCVYSKEEDGSTCLHHAAKIGNLEMV 733
              +++++ TPL  A  + H +    ++   +R       +  G T L  A   G+++ V
Sbjct: 645 LIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCV 704

Query: 734 SLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASF 793
            LLL  G    +A D  G T +   A     + +  LL   A V   D +    +H AS 
Sbjct: 705 HLLLEKGST-ADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASA 763

Query: 794 TGSAAIAEVLLNARCDLH----AVNYHGDTPLHIAARESYHDCVLLFL 837
            G  A+   LL A          V+Y G +P+H A+   + DC+ L L
Sbjct: 764 CGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLL 811



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 56/208 (26%), Positives = 90/208 (43%), Gaps = 8/208 (3%)

Query: 652 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 711
           +TPL  A   G V+  H+LL+ G+  +A D + RT L    V    +    ++     V 
Sbjct: 689 QTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVL 748

Query: 712 SKEEDGSTCLHHAAKIGNLEMVSLL----LSTGQVDVNAQDSGGWTPIIWAAEHKHIEVI 767
            ++  G T +H A+  G+  ++  L    LST  +D    D  G++P+ WA+   H + +
Sbjct: 749 CRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGV-DYSGYSPMHWASYTGHEDCL 807

Query: 768 RMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA--RCDLHAVNYHGDTPLHIAA 825
            +LL       L  N     LH A      +  E+LL A     +++ +  G TPLH AA
Sbjct: 808 ELLLEHSPFSYLEGNPFT-PLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAA 866

Query: 826 RESYHDCVLLFLSRGANPELRNKEGDTA 853
                  + + L   A     +  G TA
Sbjct: 867 FADNVSGLRMLLQHQAEVNATDHTGRTA 894



 Score = 39.3 bits (90), Expect = 0.022
 Identities = 21/76 (27%), Positives = 38/76 (50%), Gaps = 1/76 (1%)

Query: 620  LYLSVKQGELQKVILMLLDNLDPNF-QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 678
            L+L+  +G  +  +++L +  D     +   + + PLH AA+ G   +   LL  GA + 
Sbjct: 929  LHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVL 988

Query: 679  AVDKQQRTPLMEAVVN 694
            AVD++  TP +    N
Sbjct: 989  AVDEEGHTPALACAPN 1004


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,101,033
Number of Sequences: 37866
Number of extensions: 3023513
Number of successful extensions: 101846
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1512
Number of HSP's successfully gapped in prelim test: 780
Number of HSP's that attempted gapping in prelim test: 35252
Number of HSP's gapped (non-prelim): 28052
length of query: 1176
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1063
effective length of database: 13,968,660
effective search space: 14848685580
effective search space used: 14848685580
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press