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Search of human proteins with 156142197
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
(1210 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 2479 0.0
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 2393 0.0
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 1113 0.0
gi|224465235 euchromatic histone-lysine N-methyltransferase 1 is... 384 e-106
gi|13375930 suppressor of variegation 3-9 homolog 2 [Homo sapiens] 155 2e-37
gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens] 153 8e-37
gi|194306650 SET domain and mariner transposase fusion [Homo sap... 139 1e-32
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 128 4e-29
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 120 8e-27
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 120 1e-26
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 117 7e-26
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 117 7e-26
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 117 7e-26
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 117 7e-26
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 117 7e-26
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 117 7e-26
gi|224177469 SET domain, bifurcated 1 isoform 2 [Homo sapiens] 112 2e-24
gi|224177467 SET domain, bifurcated 1 isoform 1 [Homo sapiens] 112 2e-24
gi|34304381 inversin isoform a [Homo sapiens] 112 3e-24
gi|34304379 inversin isoform b [Homo sapiens] 112 3e-24
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 110 8e-24
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 110 8e-24
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 109 1e-23
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 108 3e-23
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 108 3e-23
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 108 3e-23
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 108 3e-23
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 107 7e-23
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 107 7e-23
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 107 9e-23
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2 isoform
a [Homo sapiens]
Length = 1210
Score = 2479 bits (6424), Expect = 0.0
Identities = 1210/1210 (100%), Positives = 1210/1210 (100%)
Query: 1 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE 60
MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE
Sbjct: 1 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE 60
Query: 61 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP 120
PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP
Sbjct: 61 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP 120
Query: 121 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV 180
SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV
Sbjct: 121 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV 180
Query: 181 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL 240
HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL
Sbjct: 181 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL 240
Query: 241 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE 300
GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE
Sbjct: 241 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE 300
Query: 301 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR 360
EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR
Sbjct: 301 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR 360
Query: 361 KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF 420
KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF
Sbjct: 361 KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF 420
Query: 421 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL 480
EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL
Sbjct: 421 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL 480
Query: 481 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA 540
CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA
Sbjct: 481 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA 540
Query: 541 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA 600
SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA
Sbjct: 541 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA 600
Query: 601 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ 660
DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ
Sbjct: 601 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ 660
Query: 661 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT 720
GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT
Sbjct: 661 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT 720
Query: 721 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA 780
PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA
Sbjct: 721 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA 780
Query: 781 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA 840
QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA
Sbjct: 781 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA 840
Query: 841 RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA 900
RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA
Sbjct: 841 RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA 900
Query: 901 LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS 960
LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS
Sbjct: 901 LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS 960
Query: 961 TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA 1020
TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA
Sbjct: 961 TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA 1020
Query: 1021 CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR 1080
CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR
Sbjct: 1021 CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR 1080
Query: 1081 EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS 1140
EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS
Sbjct: 1081 EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS 1140
Query: 1141 SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP 1200
SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP
Sbjct: 1141 SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP 1200
Query: 1201 ELGSLPPVNT 1210
ELGSLPPVNT
Sbjct: 1201 ELGSLPPVNT 1210
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2 isoform
b [Homo sapiens]
Length = 1176
Score = 2393 bits (6202), Expect = 0.0
Identities = 1176/1210 (97%), Positives = 1176/1210 (97%), Gaps = 34/1210 (2%)
Query: 1 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE 60
MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE
Sbjct: 1 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE 60
Query: 61 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP 120
PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP
Sbjct: 61 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP 120
Query: 121 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV 180
SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV
Sbjct: 121 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV 180
Query: 181 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL 240
HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL
Sbjct: 181 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL 240
Query: 241 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE 300
GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE
Sbjct: 241 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE 300
Query: 301 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR 360
EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR
Sbjct: 301 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR 360
Query: 361 KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF 420
KREPPRAKEPRGV SNDTSSLETERGF
Sbjct: 361 KREPPRAKEPRGV----------------------------------SNDTSSLETERGF 386
Query: 421 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL 480
EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL
Sbjct: 387 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL 446
Query: 481 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA 540
CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA
Sbjct: 447 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA 506
Query: 541 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA 600
SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA
Sbjct: 507 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA 566
Query: 601 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ 660
DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ
Sbjct: 567 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ 626
Query: 661 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT 720
GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT
Sbjct: 627 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT 686
Query: 721 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA 780
PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA
Sbjct: 687 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA 746
Query: 781 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA 840
QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA
Sbjct: 747 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA 806
Query: 841 RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA 900
RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA
Sbjct: 807 RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA 866
Query: 901 LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS 960
LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS
Sbjct: 867 LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS 926
Query: 961 TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA 1020
TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA
Sbjct: 927 TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA 986
Query: 1021 CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR 1080
CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR
Sbjct: 987 CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR 1046
Query: 1081 EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS 1140
EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS
Sbjct: 1047 EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS 1106
Query: 1141 SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP 1200
SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP
Sbjct: 1107 SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP 1166
Query: 1201 ELGSLPPVNT 1210
ELGSLPPVNT
Sbjct: 1167 ELGSLPPVNT 1176
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1 isoform
1 [Homo sapiens]
Length = 1298
Score = 1113 bits (2880), Expect = 0.0
Identities = 580/1179 (49%), Positives = 757/1179 (64%), Gaps = 116/1179 (9%)
Query: 108 LLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEP 167
L GHA K+ P KG R + +PP+ +G+A
Sbjct: 147 LPGHAAKTLPGGAGKG-----RTPSAFPQTPAAPPATLG-----------EGSADTEDRK 190
Query: 168 PPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFR-MSDDVHSLGKVTSDLAK 226
PA P KVHRARKTM K G K P E++ R + + K SD +
Sbjct: 191 LPA---PGADVKVHRARKTMPKSVVGLHAA-SKDPREVREARDHKEPKEEINKNISDFGR 246
Query: 227 RRKLNSGGGLSEELGS---------------------------ARRSGEVTLTKGDPGSL 259
++ L L + L RR G +L +
Sbjct: 247 QQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKV 306
Query: 260 EEWETVV--------------GDD----FSLYYDSYSVDERVDSDSKSEVEA-------- 293
+ TV+ G+ SL+ + S++ D D E+E
Sbjct: 307 LKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDDGHGAEQ 366
Query: 294 ----------LTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA- 342
+++ E + ++ + E EEE+E + E+EE G++SD S S +K
Sbjct: 367 AAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSESSIKKKF 426
Query: 343 -KKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGV----GSSGPSE---------YMEVP 388
K+K + DSPW+KP+RKRR+R K+P G G S+G +E YMEV
Sbjct: 427 LKRKGKTDSPWIKPARKRRRRS---RKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVS 483
Query: 389 LGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMA 448
L SL+L +G LS G++N LET+ G +E+PLCSCRME PK I+ A ++CMA
Sbjct: 484 LDSLDLRVKGILSSQAEGLANGPDVLETD-GLQEVPLCSCRMETPKSREITTLANNQCMA 542
Query: 449 TESVDGELSGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLE 508
TESVD EL C +++K E MRPS++ L+VLCE HR RMVKH CCPGCGYFCTAG F+E
Sbjct: 543 TESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFME 602
Query: 509 CHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAP-PP 567
C P+ ++HRFHK C S++N +CPHCGE++S+A+EVTI + D + T P P
Sbjct: 603 CQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTS----TVTPVPGQE 658
Query: 568 LSQDVPGRADTSQPSAR--MRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPL 625
+ GRADT+ SA + + + + D +GP+ G GL
Sbjct: 659 KGSALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPA-----GLGRPTPGLSQ 713
Query: 626 GPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSK 685
GPG+E LE AL+ +SE+ KKLRFHP+QLY S +QGELQKV+LML+D +DPNF+ + Q+K
Sbjct: 714 GPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNK 773
Query: 686 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 745
R+PLHAAA+ G V+ICH+L+QAGANI+ + QRTPLMEA NNHLE +Y+++ G V
Sbjct: 774 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 833
Query: 746 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL 805
K+ +GSTCLH AAK G+ E+V LLS GQ+DVN QD GGWTP+IWA E+KH++++++LL
Sbjct: 834 PKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLL 893
Query: 806 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 865
++G+D+ + DNEENICLHWA+F+G IAE+LL A+CDLHAVN HGD+PLHIAARE+ +D
Sbjct: 894 SKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYD 953
Query: 866 CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRD 925
CV+LFLSR ++ L+NKEG+T S VW ALQ+++ L+ +R E+I+ RD
Sbjct: 954 CVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRD 1013
Query: 926 VARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNC 985
+ARGYE +PIPCVN VD EPCP +YKY+S+NC TS MNIDRNITHLQ+C C+DDCSSSNC
Sbjct: 1014 IARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNC 1073
Query: 986 LCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRT 1045
+CGQLS+RCWYDKDGRLL EFN EPPLIFECN ACSCWRNC+NRVVQ+G++ RLQLYRT
Sbjct: 1074 MCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRT 1133
Query: 1046 AKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYG 1105
MGWGVR+LQ IP GTF+CEYVGELISD+EADVRE+DSYLFDLDNKDGEVYCIDAR+YG
Sbjct: 1134 RDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYG 1193
Query: 1106 NISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKY 1165
N+SRFINH C+PN++PVRVFM HQDLRFPRIAFFS+R I GE+LGFDYG+RFWDIK K
Sbjct: 1194 NVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKL 1253
Query: 1166 FTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLPELGS 1204
F+C+CGS KC+HS+ A+A Q+ A+ + + LP+ S
Sbjct: 1254 FSCRCGSPKCRHSSAALAQRQASAAQ-EAQEDGLPDTSS 1291
>gi|224465235 euchromatic histone-lysine N-methyltransferase 1
isoform 2 [Homo sapiens]
Length = 808
Score = 384 bits (985), Expect = e-106
Identities = 250/681 (36%), Positives = 348/681 (51%), Gaps = 115/681 (16%)
Query: 108 LLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEP 167
L GHA K+ P KG R + +PP+ +G+A
Sbjct: 147 LPGHAAKTLPGGAGKG-----RTPSAFPQTPAAPPATLG-----------EGSADTEDRK 190
Query: 168 PPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFR-MSDDVHSLGKVTSDLAK 226
PA P KVHRARKTM K G K P E++ R + + K SD +
Sbjct: 191 LPA---PGADVKVHRARKTMPKSVVGLHAA-SKDPREVREARDHKEPKEEINKNISDFGR 246
Query: 227 RRKLNSGGGLSEELGS---------------------------ARRSGEVTLTKGDPGSL 259
++ L L + L RR G +L +
Sbjct: 247 QQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKV 306
Query: 260 EEWETVV--------------GDD----FSLYYDSYSVDERVDSDSKSEVEA-------- 293
+ TV+ G+ SL+ + S++ D D E+E
Sbjct: 307 LKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDDGHGAEQ 366
Query: 294 ----------LTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRK-- 341
+++ E + ++ + E EEE+E + E+EE G++SD S S +K
Sbjct: 367 AAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSESSIKKKF 426
Query: 342 AKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNG----VGSSGPSE---------YMEVP 388
K+K + DSPW+KP+RKRR+R K+P G G S+G +E YMEV
Sbjct: 427 LKRKGKTDSPWIKPARKRRRRS---RKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVS 483
Query: 389 LGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMA 448
L SL+L +G LS G++N LET+ G +E+PLCSCRME PK I+ A ++CMA
Sbjct: 484 LDSLDLRVKGILSSQAEGLANGPDVLETD-GLQEVPLCSCRMETPKSREITTLANNQCMA 542
Query: 449 TESVDGELSGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLE 508
TESVD EL C +++K E MRPS++ L+VLCE HR RMVKH CCPGCGYFCTAG F+E
Sbjct: 543 TESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFME 602
Query: 509 CHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAP-PP 567
C P+ ++HRFHK C S++N +CPHCGE++S+A+EVTI + D T P P
Sbjct: 603 CQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKAD----TTSTVTPVPGQE 658
Query: 568 LSQDVPGRADTSQPSAR--MRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPL 625
+ GRADT+ SA + + + + D +GP+ G GL
Sbjct: 659 KGSALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPA-----GLGRPTPGLSQ 713
Query: 626 GPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSK 685
GPG+E LE AL+ +SE+ KKLRFHP+QLY S +QGELQKV+LML+D +DPNF+ + Q+K
Sbjct: 714 GPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNK 773
Query: 686 RTPLHAAAQKGSVEICHVLLQ 706
R+PLHAAA+ G V+ICH+L+Q
Sbjct: 774 RSPLHAAAEAGHVDICHMLVQ 794
>gi|13375930 suppressor of variegation 3-9 homolog 2 [Homo sapiens]
Length = 350
Score = 155 bits (392), Expect = 2e-37
Identities = 98/258 (37%), Positives = 137/258 (53%), Gaps = 29/258 (11%)
Query: 939 NGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDK 998
N VD E P D+ YI+E +++ T CT DC C + + Y+K
Sbjct: 98 NTVDLEGPPSDFYYINEYKPAPGISLVNEATFGCSCT---DCFFQKCCPAEAGVLLAYNK 154
Query: 999 DGRLLQEFNKIEPPL-IFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAK-MGWGVRALQ 1056
+ ++ KI P I+ECN C C +C NR+VQ G + L ++RT+ GWGV+ L
Sbjct: 155 NQQI-----KIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLV 209
Query: 1057 TIPQGTFICEYVGELISDAEADVR------EDDSYLFDLDNKDGEVYCIDARYYGNISRF 1110
I + +F+ EYVGE+I+ EA+ R + +YLFDLD + E + +DA YGN+S F
Sbjct: 210 KIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDE-FTVDAARYGNVSHF 268
Query: 1111 INHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDY-----GDRFWDI---- 1161
+NH CDPN+ VF+ + D R PRIA FS+R I GEEL FDY GD D
Sbjct: 269 VNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHS 328
Query: 1162 ---KSKYFTCQCGSEKCK 1176
K C+CG+ C+
Sbjct: 329 PAKKRVRTVCKCGAVTCR 346
>gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens]
Length = 412
Score = 153 bits (387), Expect = 8e-37
Identities = 102/273 (37%), Positives = 141/273 (51%), Gaps = 48/273 (17%)
Query: 939 NGVDGEPCPEDYKYISENCETSTMNIDRNITHLQ---HCTCVDDC---SSSNCLCGQLSI 992
N VD + P + YI+E + IT Q C C DC + C G
Sbjct: 149 NEVDLDGPPRAFVYINE------YRVGEGITLNQVAVGCEC-QDCLWAPTGGCCPGASLH 201
Query: 993 RCWYDKDGRLLQEFNKIEPPL-IFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAK-MGW 1050
+ Y+ G++ ++ L I+ECN C C +C NRVVQ GI+ L ++RT GW
Sbjct: 202 KFAYNDQGQV-----RLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGW 256
Query: 1051 GVRALQTIPQGTFICEYVGELISDAEADVR------EDDSYLFDLDNKDGEVYCIDARYY 1104
GVR L+ I + +F+ EYVGE+I+ EA+ R + +YLFDLD + +VY +DA YY
Sbjct: 257 GVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVE-DVYTVDAAYY 315
Query: 1105 GNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDI--- 1161
GNIS F+NH CDPN+ VF+ + D R PRIAFF++R IR GEEL FDY + +
Sbjct: 316 GNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDME 375
Query: 1162 ------------------KSKYFTCQCGSEKCK 1176
K C+CG+E C+
Sbjct: 376 STRMDSNFGLAGLPGSPKKRVRIECKCGTESCR 408
>gi|194306650 SET domain and mariner transposase fusion [Homo sapiens]
Length = 684
Score = 139 bits (351), Expect = 1e-32
Identities = 90/277 (32%), Positives = 136/277 (49%), Gaps = 37/277 (13%)
Query: 925 DVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDD-CSSS 983
DVA G EN+P V P ++Y ++ +ID C CV C
Sbjct: 29 DVACGQENLP---VGAWPPGAAPAPFQYTPDHVVGPGADIDPTQITFPGCICVKTPCLPG 85
Query: 984 NCLCGQLSIRCWYDKDGRL--LQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQ 1041
C C + YD + L + K P +FECN C C +C+NRVVQ G++ Q
Sbjct: 86 TCSCLRHGEN--YDDNSCLRDIGSGGKYAEP-VFECNVLCRCSDHCRNRVVQKGLQFHFQ 142
Query: 1042 LYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEA------DVREDDSYLFDLDNK--D 1093
+++T K GWG+R L+ IP+G F+CEY GE++ +E + D +Y+ + +
Sbjct: 143 VFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREHVYN 202
Query: 1094 GEVY--CIDARYYGNISRFINHLCDPNI--IPVRVFMLHQDLRFPRIAFFSSRDIRTGEE 1149
G+V +D Y GNI RF+NH C+PN+ IPVR+ D P++A F+++DI EE
Sbjct: 203 GQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRI-----DSMVPKLALFAAKDIVPEEE 257
Query: 1150 LGFDYGDRFWDIK-----------SKYFTCQCGSEKC 1175
L +DY R+ ++ C CG++ C
Sbjct: 258 LSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSC 294
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 128 bits (321), Expect = 4e-29
Identities = 89/274 (32%), Positives = 137/274 (50%), Gaps = 37/274 (13%)
Query: 646 KLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLL 705
KLR P L ++ G+ +V ++ D NFQ ++ KRTPLHAAA G EI +L+
Sbjct: 5 KLRDQP-SLVQAIFNGDPDEVRALIFKKEDVNFQDNE--KRTPLHAAAYLGDAEIIELLI 61
Query: 706 QAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEED--------------- 750
+GA +NA D + TPL AV + E + +++ V +++++
Sbjct: 62 LSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVK 121
Query: 751 ------------------GSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWA 792
G T LHHAA G+ EMV LLLS G ++NA D I WA
Sbjct: 122 CAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRG-ANINAFDKKDRRAIHWA 180
Query: 793 AEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGD 852
A HIEV+++L++ GA+VT D + LH A+ +G ++ + LL+ D++ N +G+
Sbjct: 181 AYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGN 240
Query: 853 TPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
TPLH+A V + GA +N++G T
Sbjct: 241 TPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFT 274
Score = 94.0 bits (232), Expect = 8e-19
Identities = 66/235 (28%), Positives = 100/235 (42%), Gaps = 2/235 (0%)
Query: 652 RQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANI 711
R ++ + G ++ V L++ + + + TPLHAAA G + + LL G ++
Sbjct: 175 RAIHWAAYMGHIEVVKLLVSHGAEVTCKD--KKSYTPLHAAASSGMISVVKYLLDLGVDM 232
Query: 712 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 771
N + TPL A N V ++ G V K E G T LH AA + + LL
Sbjct: 233 NEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 292
Query: 772 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
DVN + G TP+ A H + ++ GA + D N LH A+ G
Sbjct: 293 VGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHE 352
Query: 832 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
+ L+ + D HG PLH+AA + DC LS G + + + G T
Sbjct: 353 LLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRT 407
Score = 90.9 bits (224), Expect = 7e-18
Identities = 57/201 (28%), Positives = 101/201 (50%), Gaps = 2/201 (0%)
Query: 687 TPLHAAAQKGSVEIC-HVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 745
TPLH AA +C +L+ GA++N K +TPL ++ ++ ++Q G +
Sbjct: 274 TPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVID 333
Query: 746 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL 805
++++G+T LH AA+ G+ +++ L+++G D + G P+ AA + R LL
Sbjct: 334 CEDKNGNTPLHIAARYGHELLINTLITSG-ADTAKRGIHGMFPLHLAALSGFSDCCRKLL 392
Query: 806 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 865
+ G D+ D+ CLH A+ G+ +LLN D + + G +PLH AA +
Sbjct: 393 SSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQ 452
Query: 866 CVLLFLSRGANPELRNKEGDT 886
C+ + GA+ ++ G T
Sbjct: 453 CLFALVGSGASVNDLDERGCT 473
Score = 86.3 bits (212), Expect = 2e-16
Identities = 65/225 (28%), Positives = 106/225 (47%), Gaps = 8/225 (3%)
Query: 669 MLLDNLDPNFQSDQQ--SKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 726
+L+ N +P D Q + +TPL + G + + LL GAN++A DK RT L
Sbjct: 635 LLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGA 694
Query: 727 VNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMV-SLLLSTGQVDVN--AQDS 783
V H E ++Q G ++ G T +H +A G++ ++ +LL S +D N D+
Sbjct: 695 VTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADN 754
Query: 784 GGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLN--AR 841
G+T + WA + H + +LL + T+ LH A + AE+L++
Sbjct: 755 HGYTALHWACYNGHETCVELLLEQEV-FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGA 813
Query: 842 CDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
++A + G TPLH AA + +C+ L LS A + G T
Sbjct: 814 SIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKT 858
Score = 85.9 bits (211), Expect = 2e-16
Identities = 70/244 (28%), Positives = 112/244 (45%), Gaps = 11/244 (4%)
Query: 653 QLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 712
+L L + E +LM D SD ++ +PLH AA G + VL+Q+ +++
Sbjct: 518 RLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLD 577
Query: 713 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEED-GSTCLHHAAKIGNLEMVSLLL 771
+ RTPL A H+E ++ +G + K+ T +H AA G+ E + LL+
Sbjct: 578 VRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLI 637
Query: 772 STG--QVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTG 829
Q V+ QD G TP++ + + H + + LL +GA+V D LH + TG
Sbjct: 638 GNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTG 697
Query: 830 SAAIAEVLL--NARCDLHAVNYHGDTPLHIAARESYHDCVLLFL----SRGANPELRNKE 883
+ LL A+C L + G TP+H++A + + L S ANP +
Sbjct: 698 HEECVDALLQHGAKCLLR--DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNH 755
Query: 884 GDTA 887
G TA
Sbjct: 756 GYTA 759
Score = 84.7 bits (208), Expect = 5e-16
Identities = 73/261 (27%), Positives = 119/261 (45%), Gaps = 14/261 (5%)
Query: 628 GREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 687
G E L L+ ++ K+ L+L+ G +L D + D RT
Sbjct: 350 GHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDD--FGRT 407
Query: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 747
LHAAA G++E ++LL GA+ N DK R+PL A N + + +V G V
Sbjct: 408 CLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDL 467
Query: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL-- 805
+E G T LH+AA L + +D G+ + ++A + H ++++
Sbjct: 468 DERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASE 527
Query: 806 --------TRGAD-VTLTDNEENIC-LHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 855
T G D ++ +DN I LH A++ G EVL+ + DL N G TPL
Sbjct: 528 TPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPL 587
Query: 856 HIAARESYHDCVLLFLSRGAN 876
+AA + + +CV + +++GA+
Sbjct: 588 DLAAFKGHVECVDVLINQGAS 608
Score = 83.2 bits (204), Expect = 1e-15
Identities = 71/226 (31%), Positives = 106/226 (46%), Gaps = 8/226 (3%)
Query: 667 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 726
+L ++D N + T LH A G E C LL + +PL AV
Sbjct: 738 LLQSAASMDANPATADNHGYTALHWACYNGH-ETCVELLLEQEVFQKTEGNAFSPLHCAV 796
Query: 727 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 784
+N++ A ++ G V + + G T LH AA ++E + LLLS VN+ DS
Sbjct: 797 INDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHN-AQVNSVDST 855
Query: 785 GWTPIIWAAEHKHIEVIRMLLTRG-ADVTLTDNEENICLHWASFTGSAAIAEVLLNARCD 843
G TP++ AAE+ + ML++ A++TL DN +N LH A G A ++L D
Sbjct: 856 GKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITD 915
Query: 844 ---LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
++A N TPLH+AAR V L +GA+ ++ G T
Sbjct: 916 RNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYT 961
Score = 72.4 bits (176), Expect = 2e-12
Identities = 66/263 (25%), Positives = 112/263 (42%), Gaps = 47/263 (17%)
Query: 681 DQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR 740
+ ++ TPLH AA+ G + + L+ +GA+ PL A ++ + R ++
Sbjct: 335 EDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSS 394
Query: 741 GGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEV 800
G + + ++ G TCLH AA GNLE ++LLL+TG D N +D G +P+ +AA + + +
Sbjct: 395 GFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTG-ADFNKKDKFGRSPLHYAAANCNYQC 453
Query: 801 IRMLLTRGADVTLTDNEENICLHWA--SFTGSAAIAEVLLNA-------RCDLHAVNYHG 851
+ L+ GA V D LH+A S T + +L N + +AV+Y
Sbjct: 454 LFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSA 513
Query: 852 D-------------------------------------TPLHIAARESYHDCVLLFLSRG 874
+PLH+AA +H + + +
Sbjct: 514 AYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSL 573
Query: 875 ANPELRNKEGDTAWDLTPERSDV 897
+ ++RN G T DL + V
Sbjct: 574 LDLDVRNSSGRTPLDLAAFKGHV 596
Score = 72.0 bits (175), Expect = 3e-12
Identities = 59/203 (29%), Positives = 96/203 (47%), Gaps = 9/203 (4%)
Query: 686 RTPLHAAAQKGSVEICHVLLQAGANINA----VDKQQRTPLMEAVVNNHLEVARYMVQRG 741
RTP+H +A G + + LLQ+ A+++A D T L A N H ++++
Sbjct: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 779
Query: 742 GCVYSKEEDGSTCLHHAAKIGNLEMVSLLL--STGQVDVNAQDSGGWTPIIWAAEHKHIE 799
V+ K E + H A I + E + +L + G VNA DS G TP+ AA H+E
Sbjct: 780 --VFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVE 837
Query: 800 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLL-NARCDLHAVNYHGDTPLHIA 858
+++LL+ A V D+ L A+ G E+L+ +A +L + +T LH+A
Sbjct: 838 CLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLA 897
Query: 859 ARESYHDCVLLFLSRGANPELRN 881
+ + LL L + + L N
Sbjct: 898 CSKGHETSALLILEKITDRNLIN 920
Score = 53.5 bits (127), Expect = 1e-06
Identities = 47/168 (27%), Positives = 65/168 (38%), Gaps = 39/168 (23%)
Query: 669 MLLDNLDPNFQSDQQSK-RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVV 727
ML+D L + + SK RTPLHAAA VE +LL A +N+VD +TPLM A
Sbjct: 806 MLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAE 865
Query: 728 NNHLEVARYMVQRGGCVYSKEEDGS----------------------------------- 752
N +V + +++
Sbjct: 866 NGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAA 925
Query: 753 --TCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHI 798
T LH AA+ G +V LL G V A D G+TP + A +K +
Sbjct: 926 LQTPLHVAARNGLTMVVQELLGKG-ASVLAVDENGYTPALACAPNKDV 972
Score = 53.1 bits (126), Expect = 2e-06
Identities = 37/111 (33%), Positives = 55/111 (49%)
Query: 777 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEV 836
DVN QD+ TP+ AA E+I +L+ GA V D++ LH A + S +V
Sbjct: 33 DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQV 92
Query: 837 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
LL D++A + + TPLHIAA C + +N + ++ G TA
Sbjct: 93 LLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTA 143
Score = 39.7 bits (91), Expect = 0.018
Identities = 24/76 (31%), Positives = 38/76 (50%), Gaps = 1/76 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNF-QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 712
L+L+ +G +L+L D N + + +TPLH AA+ G + LL GA++
Sbjct: 894 LHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVL 953
Query: 713 AVDKQQRTPLMEAVVN 728
AVD+ TP + N
Sbjct: 954 AVDENGYTPALACAPN 969
Score = 37.4 bits (85), Expect = 0.087
Identities = 33/124 (26%), Positives = 57/124 (45%), Gaps = 5/124 (4%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGAN--- 710
L ++ + G+ V ML+ + SK T LH A KG ++L+ +
Sbjct: 860 LMMAAENGQTNTVE-MLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNL 918
Query: 711 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGST-CLHHAAKIGNLEMVSL 769
INA + +TPL A N V + ++ +G V + +E+G T L A + ++L
Sbjct: 919 INATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLAL 978
Query: 770 LLST 773
+L+T
Sbjct: 979 ILAT 982
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 120 bits (301), Expect = 8e-27
Identities = 91/304 (29%), Positives = 146/304 (48%), Gaps = 6/304 (1%)
Query: 618 LSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPN 677
L+A+ + G + K L+ +++ K L+++ K+ + KV+ +LL + +
Sbjct: 368 LTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRI-KVMELLLKH-GAS 425
Query: 678 FQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYM 737
Q+ +S TP+H AA G V I L+ GA+ N + + T L A + EV RY+
Sbjct: 426 IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Query: 738 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKH 797
VQ G V +K +D T LH +A++G ++V LL G NA + G+TP+ +A H
Sbjct: 486 VQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQG-ASPNAATTSGYTPLHLSAREGH 544
Query: 798 IEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 857
+V LL GA +++T + LH A+ G +A +LL A G TPLH+
Sbjct: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604
Query: 858 AARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIR 917
AA LL L +GA+P K G T + +++ + A L L G A+
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL---LEYGADANAVT 661
Query: 918 TEKI 921
+ I
Sbjct: 662 RQGI 665
Score = 112 bits (279), Expect = 3e-24
Identities = 78/244 (31%), Positives = 117/244 (47%), Gaps = 3/244 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ + G+ + V ++ D ++ + +TPLH +A+ G +I LLQ GA+ NA
Sbjct: 470 LHMAARSGQAEVVRYLVQDGAQ--VEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
TPL + H +VA +++ G + + G T LH AAK G LE+ +LLL
Sbjct: 528 ATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
+A G TP+ AA + + +V +LL +GA LH A+ I
Sbjct: 588 S-ASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDI 646
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
A LL D +AV G +H+AA+E + D V L L R AN L NK G T L +
Sbjct: 647 ATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQ 706
Query: 894 RSDV 897
V
Sbjct: 707 EDRV 710
Score = 105 bits (262), Expect = 3e-22
Identities = 81/259 (31%), Positives = 119/259 (45%), Gaps = 30/259 (11%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+L+ K+G ++ V +L + N + + T LH A+ G E+ VL+ GAN+NA
Sbjct: 78 LHLASKEGHVEVVSELL--QREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNA 135
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ TPL A NHLEV ++++ G EDG T L A + G+ ++VSLLL
Sbjct: 136 QSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195
Query: 774 G--------------------------QVDVNA--QDSGGWTPIIWAAEHKHIEVIRMLL 805
Q D NA + G+TP+ AA + +I V +LL
Sbjct: 196 DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLL 255
Query: 806 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 865
R A V T + LH AS G+A + ++LL+ + A G TPLH AR +
Sbjct: 256 NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQ 315
Query: 866 CVLLFLSRGANPELRNKEG 884
V + L R A + K G
Sbjct: 316 VVEMLLDRAAPILSKTKNG 334
Score = 104 bits (259), Expect = 6e-22
Identities = 70/234 (29%), Positives = 116/234 (49%), Gaps = 3/234 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ K G+L+ L+L + P+ +S TPLH AA + ++ +LL GA+ +A
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAG--KSGLTPLHVAAHYDNQKVALLLLDQGASPHA 626
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
K TPL A N +++A +++ G + G +H AA+ G+++MVSLLL
Sbjct: 627 AAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 686
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
+VN + G TP+ AA+ + V +L+ +GA V LH G+ I
Sbjct: 687 N-ANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKI 745
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
LL ++A +G TPLH AA++ + + + L A+P G+TA
Sbjct: 746 VNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTA 799
Score = 103 bits (257), Expect = 1e-21
Identities = 74/268 (27%), Positives = 130/268 (48%), Gaps = 3/268 (1%)
Query: 619 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 678
+A+ + G+ + + LV ++ K + L++S + G+ V +L PN
Sbjct: 468 TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527
Query: 679 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV 738
+ S TPLH +A++G ++ LL GA+++ K+ TPL A LEVA ++
Sbjct: 528 ATT--SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL 585
Query: 739 QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHI 798
Q+ + + G T LH AA N ++ LLL G +A G+TP+ AA+ +
Sbjct: 586 QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG-ASPHAAAKNGYTPLHIAAKKNQM 644
Query: 799 EVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 858
++ LL GAD + +H A+ G + +LL +++ N G TPLH+A
Sbjct: 645 DIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLA 704
Query: 859 ARESYHDCVLLFLSRGANPELRNKEGDT 886
A+E + + +++GA+ + + K G T
Sbjct: 705 AQEDRVNVAEVLVNQGAHVDAQTKMGYT 732
Score = 95.5 bits (236), Expect = 3e-19
Identities = 81/287 (28%), Positives = 135/287 (47%), Gaps = 33/287 (11%)
Query: 630 EALEKALVIQESERRKKLRFHPRQLYL-SVKQGELQKVILMLLDNLDPNFQSDQQSKRTP 688
E EK ++ R +K + YL + + G L+K + + + +D N + Q+
Sbjct: 20 EEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICN--QNGLNA 77
Query: 689 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 748
LH A+++G VE+ LLQ AN++A K+ T L A + EV + +V G V ++
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
Query: 749 EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL--- 805
++G T L+ AA+ +LE+V LL G A + G+TP+ A + H +V+ +LL
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATED-GFTPLAVALQQGHDQVVSLLLEND 196
Query: 806 TRG-----------------ADVTLTDNEEN---------ICLHWASFTGSAAIAEVLLN 839
T+G A L N+ N LH A+ G+ +A +LLN
Sbjct: 197 TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLN 256
Query: 840 ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
+ + TPLH+A++ + V L L RGA + + ++G T
Sbjct: 257 RAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLT 303
Score = 88.6 bits (218), Expect = 3e-17
Identities = 72/287 (25%), Positives = 122/287 (42%), Gaps = 39/287 (13%)
Query: 635 ALVIQESER---RKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHA 691
AL++Q K F P L+++ G + L+L +F + ++ TPLH
Sbjct: 219 ALLLQNDNNADVESKSGFTP--LHIAAHYGNINVATLLLNRAAAVDFTA--RNDITPLHV 274
Query: 692 AAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDG 751
A+++G+ + +LL GA I+A + TPL + H +V ++ R + SK ++G
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG 334
Query: 752 STCLHHAAKIGNLEMVSLLLSTG--------------------------------QVDVN 779
+ LH A + +L V LLL + + N
Sbjct: 335 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN 394
Query: 780 AQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLN 839
A+ G+TP+ A + I+V+ +LL GA + +H A+F G I L++
Sbjct: 395 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH 454
Query: 840 ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
+ N G+T LH+AAR + V + GA E + K+ T
Sbjct: 455 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQT 501
Score = 87.0 bits (214), Expect = 1e-16
Identities = 61/200 (30%), Positives = 98/200 (49%), Gaps = 2/200 (1%)
Query: 664 QKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLM 723
QKV L+LLD + + ++ TPLH AA+K ++I LL+ GA+ NAV +Q +
Sbjct: 611 QKVALLLLDQ-GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVH 669
Query: 724 EAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDS 783
A H+++ ++ R V + G T LH AA+ + + +L++ G V+AQ
Sbjct: 670 LAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG-AHVDAQTK 728
Query: 784 GGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCD 843
G+TP+ + +I+++ LL A V LH A+ G I VLL
Sbjct: 729 MGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788
Query: 844 LHAVNYHGDTPLHIAARESY 863
+ + +G+T L IA R Y
Sbjct: 789 PNELTVNGNTALGIARRLGY 808
Score = 77.8 bits (190), Expect = 6e-14
Identities = 54/184 (29%), Positives = 89/184 (48%), Gaps = 3/184 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ K+ ++ +L D N + Q +H AAQ+G V++ +LL AN+N
Sbjct: 635 LHIAAKKNQMDIATTLLEYGADANAVTRQGI--ASVHLAAQEGHVDMVSLLLGRNANVNL 692
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+K TPL A + + VA +V +G V ++ + G T LH GN+++V+ LL
Sbjct: 693 SNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQH 752
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
VNA+ G+TP+ AA+ H +I +LL A N L A G ++
Sbjct: 753 S-AKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISV 811
Query: 834 AEVL 837
+ L
Sbjct: 812 VDTL 815
Score = 33.9 bits (76), Expect = 0.96
Identities = 16/45 (35%), Positives = 27/45 (60%)
Query: 843 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
D++ N +G LH+A++E + + V L R AN + K+G+TA
Sbjct: 66 DINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTA 110
Score = 30.8 bits (68), Expect = 8.2
Identities = 19/75 (25%), Positives = 34/75 (45%)
Query: 280 DERVDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGR 339
++RVD K E LTE ++ E+ +E + E++ + +E +QS S S +
Sbjct: 2574 EDRVDRTVKEAEEKLTEVSQFFRDKTEKLNDELQSPEKKARPKNGKEYSSQSPTSSSPEK 2633
Query: 340 RKAKKKWRKDSPWVK 354
+ + WVK
Sbjct: 2634 VLLTELLASNDEWVK 2648
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 120 bits (300), Expect = 1e-26
Identities = 76/233 (32%), Positives = 119/233 (51%), Gaps = 3/233 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ G+ + + L++L N + + TPLH A S E VL++ A++NA
Sbjct: 20 LHVAAFLGDAEIIELLILSGARVNAKDNMWL--TPLHRAVASRSEEAVQVLIKHSADVNA 77
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
DK +TPL A N ++ A ++ V + G T LHHAA G++EMV+LLL+
Sbjct: 78 RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
G ++NA D + WAA H++V+ +L+ GA+VT D + LH A+ G +
Sbjct: 138 G-ANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINV 196
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
+ LLN ++ +N +G+T LHIA V + GAN N G T
Sbjct: 197 VKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFT 249
Score = 113 bits (283), Expect = 1e-24
Identities = 69/206 (33%), Positives = 110/206 (53%), Gaps = 7/206 (3%)
Query: 685 KRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCV 744
KRTPLH AA G EI +L+ +GA +NA D TPL AV + E + +++ V
Sbjct: 16 KRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADV 75
Query: 745 YSKEEDGSTCLHHAAK---IGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVI 801
+++++ T LH AA + E++ LLS+ VN D GG T + AA + H+E++
Sbjct: 76 NARDKNWQTPLHVAAANKAVKCAEVIIPLLSS----VNVSDRGGRTALHHAALNGHVEMV 131
Query: 802 RMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARE 861
+LL +GA++ D ++ LHWA++ G + +L+N ++ + G TPLH AA
Sbjct: 132 NLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASN 191
Query: 862 SYHDCVLLFLSRGANPELRNKEGDTA 887
+ V L+ G + N G+TA
Sbjct: 192 GQINVVKHLLNLGVEIDEINVYGNTA 217
Score = 113 bits (283), Expect = 1e-24
Identities = 67/239 (28%), Positives = 133/239 (55%), Gaps = 4/239 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+ +V + V +++ + D N + ++ +TPLH AA +V+ V++ +++N
Sbjct: 53 LHRAVASRSEEAVQVLIKHSADVNARD--KNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
D+ RT L A +N H+E+ ++ +G + + ++ LH AA +G+L++V+LL++
Sbjct: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
G +V +D G+TP+ AA + I V++ LL G ++ + N LH A + G A+
Sbjct: 171 G-AEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAV 229
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLT 891
L++ +++ N +G TPLH AA ++ C+ L ++ GA+ +++K+G + +T
Sbjct: 230 VNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMT 288
Score = 99.0 bits (245), Expect = 2e-20
Identities = 74/259 (28%), Positives = 122/259 (47%), Gaps = 37/259 (14%)
Query: 651 PRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGAN 710
P + + K + +VI+ LL +++ + + RT LH AA G VE+ ++LL GAN
Sbjct: 85 PLHVAAANKAVKCAEVIIPLLSSVNVS----DRGGRTALHHAALNGHVEMVNLLLAKGAN 140
Query: 711 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 770
INA DK+ R L A HL+V ++ G V K++ G T LH AA G + +V L
Sbjct: 141 INAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHL 200
Query: 771 LSTG-QVD-------------------------------VNAQDSGGWTPIIWAAEHKHI 798
L+ G ++D VN ++ G+TP+ +AA H
Sbjct: 201 LNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHG 260
Query: 799 EV-IRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 857
+ + +L+ GADV + + LH + G ++ L+ ++ V+ G+TPLH+
Sbjct: 261 ALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHV 320
Query: 858 AARESYHDCVLLFLSRGAN 876
AAR + + + GA+
Sbjct: 321 AARYGHELLINTLRTSGAD 339
Score = 94.7 bits (234), Expect = 5e-19
Identities = 63/225 (28%), Positives = 108/225 (48%), Gaps = 2/225 (0%)
Query: 664 QKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEIC-HVLLQAGANINAVDKQQRTPL 722
Q ++ L + N + TPLH AA +C +L+ GA++N K ++PL
Sbjct: 226 QDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPL 285
Query: 723 MEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQD 782
V+ ++ ++Q GG + ++DG+T LH AA+ G+ +++ L ++G D
Sbjct: 286 HMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSG-ADTAKCG 344
Query: 783 SGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 842
P+ AA + H + R LL+ G ++ D CLH A+ G+ ++L ++
Sbjct: 345 IHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGA 404
Query: 843 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
D H + G TPLH AA + C+ ++ GAN + G TA
Sbjct: 405 DFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTA 449
Score = 91.3 bits (225), Expect = 5e-18
Identities = 66/235 (28%), Positives = 96/235 (40%), Gaps = 2/235 (0%)
Query: 652 RQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANI 711
R L+ + G L V L++ N + TPLHAAA G + + LL G I
Sbjct: 150 RALHWAAYMGHLDVVALLI--NHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEI 207
Query: 712 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 771
+ ++ T L A N V ++ G V +G T LH AA + + LL
Sbjct: 208 DEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELL 267
Query: 772 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
DVN Q G +P+ A H + L+ G ++ D + N LH A+ G
Sbjct: 268 VNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHE 327
Query: 832 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
+ L + D H PLH+AA ++ DC LS G + +K G T
Sbjct: 328 LLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRT 382
Score = 83.2 bits (204), Expect = 1e-15
Identities = 67/251 (26%), Positives = 114/251 (45%), Gaps = 17/251 (6%)
Query: 630 EALEKALVIQESERRKKLRF----------HPRQLYLSVKQGEL---QKVILMLLDNLDP 676
E LE+A ++E E L F ++ Y S+ ++ + +LL+ +
Sbjct: 473 EELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNS 532
Query: 677 NFQ-SDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR 735
F+ SD + ++PLH AA G + VLLQ+ +++ D++ RT L A H E
Sbjct: 533 GFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVE 592
Query: 736 YMVQRGGCVYSKEE-DGSTCLHHAAKIGNLEMVSLLLSTGQVD--VNAQDSGGWTPIIWA 792
++ G ++ K+ T LH + G+ + LLL V+ +D+ G TP++ A
Sbjct: 593 ALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLA 652
Query: 793 AEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGD 852
+ HI+ + +LL + A+V D LH TG ++LL + + G
Sbjct: 653 VAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGR 712
Query: 853 TPLHIAARESY 863
TPLH AA +
Sbjct: 713 TPLHYAAARGH 723
Score = 81.6 bits (200), Expect = 4e-15
Identities = 72/270 (26%), Positives = 111/270 (41%), Gaps = 41/270 (15%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L L+V G + V L+L + N + T LH G E +LL+ +I
Sbjct: 649 LMLAVAYGHIDAVSLLL--EKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILC 706
Query: 714 VDKQQRTPLMEAVVNNHL----EVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSL 769
D + RTPL A H E+ + + C + K+ G T LH A GN + +
Sbjct: 707 KDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCF-KDNQGYTPLHWACYNGNENCIEV 765
Query: 770 LLST------------------------------GQVD---VNAQDSGGWTPIIWAAEHK 796
LL G +D V+ +D G TP+ AA
Sbjct: 766 LLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFAD 825
Query: 797 HIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLN-ARCDLHAVNYHGDTPL 855
H+E +++LL A V DN L A+ G A ++L+N A+ DL + +TPL
Sbjct: 826 HVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPL 885
Query: 856 HIAARESYHDCVLLFLSRGANPELRNKEGD 885
H+A + + C LL L + + L N++ +
Sbjct: 886 HLACSKGHEKCALLILDKIQDESLINEKNN 915
Score = 79.7 bits (195), Expect = 2e-14
Identities = 69/224 (30%), Positives = 104/224 (46%), Gaps = 16/224 (7%)
Query: 674 LDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHL 731
L F+ D K RT LHAAA G+VE +L +GA+ + DK RTPL A N H
Sbjct: 367 LSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHF 426
Query: 732 EVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 791
+V G V ++ G T LH+AA +++ +L NA D+ +
Sbjct: 427 HCIETLVTTGANVNETDDWGRTALHYAA-ASDMDRNKTILG------NAHDNS--EELER 477
Query: 792 AAEHKHIEV---IRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 848
A E K E + LL A+ ++ D E +H+A+ G E+LL +
Sbjct: 478 ARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEES 537
Query: 849 YHGDT--PLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDL 890
G T PLH+AA +H + + L + ++R+++G TA DL
Sbjct: 538 DSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDL 581
Score = 74.7 bits (182), Expect = 5e-13
Identities = 64/252 (25%), Positives = 103/252 (40%), Gaps = 33/252 (13%)
Query: 668 LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVV 727
+ LL + +F + RTPLH AA L+ GAN+N D RT L A
Sbjct: 396 IKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAA 455
Query: 728 NN----------------HLEVAR------------YMVQRGGCVYSKEEDGSTCLHHAA 759
++ LE AR +++Q ++++G +H+AA
Sbjct: 456 SDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAA 515
Query: 760 KIGNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLLTRGADVTLTDNEE 818
G+ + + LLL DSG +P+ AA + H + + +LL D+ + D +
Sbjct: 516 AYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKG 575
Query: 819 NICLHWASFTGSAAIAEVLLNARCDLHAV-NYHGDTPLHIAARESYHDCVLLFLSRGANP 877
L A+F G E L+N + N TPLH + + C+ L L NP
Sbjct: 576 RTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNP 635
Query: 878 E---LRNKEGDT 886
E +++ +G T
Sbjct: 636 EAVDVKDAKGQT 647
Score = 72.4 bits (176), Expect = 2e-12
Identities = 64/234 (27%), Positives = 106/234 (45%), Gaps = 8/234 (3%)
Query: 665 KVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLME 724
+++L + DN + D + + TPL A G ++ +LL+ AN++ VD T L
Sbjct: 626 RLLLEIADNPEAVDVKDAKGQ-TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHR 684
Query: 725 AVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL--STGQVDVNAQD 782
++ H E + ++++ + K+ G T LH+AA G+ +S LL + + D +D
Sbjct: 685 GIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKD 744
Query: 783 SGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 842
+ G+TP+ WA + + I +LL + N LH A A +LL A
Sbjct: 745 NQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFT-PLHCAIINDHGNCASLLLGA-I 802
Query: 843 DLHAVNYHGD---TPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
D V+ D TPL AA + +C+ L L A + G TA + E
Sbjct: 803 DSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAE 856
Score = 50.8 bits (120), Expect = 8e-06
Identities = 35/111 (31%), Positives = 54/111 (48%)
Query: 777 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEV 836
DVN DS TP+ AA E+I +L+ GA V DN LH A + S +V
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 837 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
L+ D++A + + TPLH+AA C + + ++ + ++ G TA
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTA 118
Score = 43.5 bits (101), Expect = 0.001
Identities = 26/84 (30%), Positives = 42/84 (50%)
Query: 803 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARES 862
ML+ + DV D+E+ LH A+F G A I E+L+ + ++A + TPLH A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 863 YHDCVLLFLSRGANPELRNKEGDT 886
+ V + + A+ R+K T
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQT 84
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 117 bits (293), Expect = 7e-26
Identities = 85/259 (32%), Positives = 133/259 (51%), Gaps = 9/259 (3%)
Query: 632 LEKALVIQESERRK----KLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 687
+E L + E E + K F P L+++ K G+++ L+L + PN ++ T
Sbjct: 549 VETVLALLEKEASQACMTKKGFTP--LHVAAKYGKVRVAELLLERDAHPNAAG--KNGLT 604
Query: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 747
PLH A +++I +LL G + ++ TPL A N +EVAR ++Q GG ++
Sbjct: 605 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 664
Query: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
G T LH AA+ G+ EMV+LLLS Q + N + G TP+ A+ H+ V +L+
Sbjct: 665 SVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723
Query: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 867
G V T LH AS G+ + + LL + D++A G +PLH AA++ + D V
Sbjct: 724 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 783
Query: 868 LLFLSRGANPELRNKEGDT 886
L L GA+P + +G T
Sbjct: 784 TLLLKNGASPNEVSSDGTT 802
Score = 115 bits (288), Expect = 3e-25
Identities = 81/250 (32%), Positives = 123/250 (49%), Gaps = 3/250 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ K+ ++ ++ LL + + +S TPLH A+ G + I LLQ GA+ N
Sbjct: 408 LHIACKKNHVR--VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 465
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ + TPL A H EVA+Y++Q V +K +D T LH AA+IG+ MV LLL
Sbjct: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE- 524
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
+ N + G TP+ AA H+E + LL + A + LH A+ G +
Sbjct: 525 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 584
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
AE+LL +A +G TPLH+A + D V L L RG +P G T + +
Sbjct: 585 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 644
Query: 894 RSDVWFALQL 903
++ V A L
Sbjct: 645 QNQVEVARSL 654
Score = 108 bits (271), Expect = 2e-23
Identities = 79/279 (28%), Positives = 135/279 (48%), Gaps = 3/279 (1%)
Query: 628 GREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 687
G + + L+ + ++ K + L+ + + G + ++ +LLD+ P Q+ ++ +
Sbjct: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHV-RISEILLDHGAP-IQAKTKNGLS 340
Query: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 747
P+H AAQ ++ +LLQ A I+ + TPL A H VA+ ++ +G S+
Sbjct: 341 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 400
Query: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
+G T LH A K ++ ++ LLL TG ++A G TP+ A+ H+ +++ LL R
Sbjct: 401 ALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 459
Query: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 867
GA +++ + LH A+ G +A+ LL + ++A TPLH AAR + + V
Sbjct: 460 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 519
Query: 868 LLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRK 906
L L ANP L G T + V L L K
Sbjct: 520 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 558
Score = 104 bits (259), Expect = 6e-22
Identities = 75/246 (30%), Positives = 114/246 (46%), Gaps = 7/246 (2%)
Query: 654 LYLSVKQG--ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANI 711
L+++ + G E+ K +L ++ + DQ TPLH AA+ G + +LL+ AN
Sbjct: 474 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ----TPLHCAARIGHTNMVKLLLENNANP 529
Query: 712 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 771
N TPL A H+E ++++ + G T LH AAK G + + LLL
Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 589
Query: 772 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
NA G TP+ A H +++++++LL RG LH A+
Sbjct: 590 ER-DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 648
Query: 832 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLT 891
+A LL +A + G TPLH+AA+E + + V L LS+ AN L NK G T L
Sbjct: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 708
Query: 892 PERSDV 897
+ V
Sbjct: 709 AQEGHV 714
Score = 96.3 bits (238), Expect = 2e-19
Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 30/259 (11%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+L+ K+G ++ V+ +L + ++ + T LH AA G E+ L+ GAN+NA
Sbjct: 82 LHLASKEGHVKMVVELLHKEII--LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 139
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
++ TPL A NHLEV +++++ G EDG T L A + G+ +V+ L++
Sbjct: 140 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 199
Query: 774 G--------------------------QVDVNAQ--DSGGWTPIIWAAEHKHIEVIRMLL 805
G Q D N G+TP+ AA ++++ V ++LL
Sbjct: 200 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 259
Query: 806 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 865
RGA V T LH AS G+ + +LL+ + TPLH AAR +
Sbjct: 260 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 319
Query: 866 CVLLFLSRGANPELRNKEG 884
+ L GA + + K G
Sbjct: 320 ISEILLDHGAPIQAKTKNG 338
Score = 86.3 bits (212), Expect = 2e-16
Identities = 59/184 (32%), Positives = 94/184 (51%), Gaps = 3/184 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ KQ +++ +L N +S Q TPLH AAQ+G E+ +LL AN N
Sbjct: 639 LHIAAKQNQVEVARSLLQYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNL 696
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+K TPL H+ VA +++ G V + G T LH A+ GN+++V LL
Sbjct: 697 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 756
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
Q DVNA+ G++P+ AA+ H +++ +LL GA ++ L A G ++
Sbjct: 757 -QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 815
Query: 834 AEVL 837
+VL
Sbjct: 816 TDVL 819
Score = 83.6 bits (205), Expect = 1e-15
Identities = 76/277 (27%), Positives = 125/277 (45%), Gaps = 17/277 (6%)
Query: 630 EALEKALVIQESERRKKLRFHPRQ--------LYLSVKQGELQKVILMLLDNLDPNFQSD 681
+AL++ +ES R+++ R R+ + + G L K + L + +D N +
Sbjct: 17 QALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDIN--TC 74
Query: 682 QQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRG 741
Q+ LH A+++G V++ LL + K+ T L A + EV R +V G
Sbjct: 75 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134
Query: 742 GCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVI 801
V ++ + G T L+ AA+ +LE+V LL G + N G+TP+ A + H V+
Sbjct: 135 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG-ANQNVATEDGFTPLAVALQQGHENVV 193
Query: 802 RMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAAR 860
L+ G T + + LH A+ A VLL + ++ G TPLHIAA
Sbjct: 194 AHLINYG-----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 248
Query: 861 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDV 897
+ L L+RGA+ + G T + R +V
Sbjct: 249 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 285
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 117 bits (293), Expect = 7e-26
Identities = 85/259 (32%), Positives = 133/259 (51%), Gaps = 9/259 (3%)
Query: 632 LEKALVIQESERRK----KLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 687
+E L + E E + K F P L+++ K G+++ L+L + PN ++ T
Sbjct: 516 VETVLALLEKEASQACMTKKGFTP--LHVAAKYGKVRVAELLLERDAHPNAAG--KNGLT 571
Query: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 747
PLH A +++I +LL G + ++ TPL A N +EVAR ++Q GG ++
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
G T LH AA+ G+ EMV+LLLS Q + N + G TP+ A+ H+ V +L+
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 867
G V T LH AS G+ + + LL + D++A G +PLH AA++ + D V
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 868 LLFLSRGANPELRNKEGDT 886
L L GA+P + +G T
Sbjct: 751 TLLLKNGASPNEVSSDGTT 769
Score = 115 bits (288), Expect = 3e-25
Identities = 81/250 (32%), Positives = 123/250 (49%), Gaps = 3/250 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ K+ ++ ++ LL + + +S TPLH A+ G + I LLQ GA+ N
Sbjct: 375 LHIACKKNHVR--VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ + TPL A H EVA+Y++Q V +K +D T LH AA+IG+ MV LLL
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE- 491
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
+ N + G TP+ AA H+E + LL + A + LH A+ G +
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
AE+LL +A +G TPLH+A + D V L L RG +P G T + +
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611
Query: 894 RSDVWFALQL 903
++ V A L
Sbjct: 612 QNQVEVARSL 621
Score = 108 bits (271), Expect = 2e-23
Identities = 79/279 (28%), Positives = 135/279 (48%), Gaps = 3/279 (1%)
Query: 628 GREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 687
G + + L+ + ++ K + L+ + + G + ++ +LLD+ P Q+ ++ +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHV-RISEILLDHGAP-IQAKTKNGLS 307
Query: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 747
P+H AAQ ++ +LLQ A I+ + TPL A H VA+ ++ +G S+
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
Query: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
+G T LH A K ++ ++ LLL TG ++A G TP+ A+ H+ +++ LL R
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 426
Query: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 867
GA +++ + LH A+ G +A+ LL + ++A TPLH AAR + + V
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
Query: 868 LLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRK 906
L L ANP L G T + V L L K
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Score = 104 bits (259), Expect = 6e-22
Identities = 75/246 (30%), Positives = 114/246 (46%), Gaps = 7/246 (2%)
Query: 654 LYLSVKQG--ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANI 711
L+++ + G E+ K +L ++ + DQ TPLH AA+ G + +LL+ AN
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ----TPLHCAARIGHTNMVKLLLENNANP 496
Query: 712 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 771
N TPL A H+E ++++ + G T LH AAK G + + LLL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 772 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
NA G TP+ A H +++++++LL RG LH A+
Sbjct: 557 ER-DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 832 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLT 891
+A LL +A + G TPLH+AA+E + + V L LS+ AN L NK G T L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Query: 892 PERSDV 897
+ V
Sbjct: 676 AQEGHV 681
Score = 96.3 bits (238), Expect = 2e-19
Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 30/259 (11%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+L+ K+G ++ V+ +L + ++ + T LH AA G E+ L+ GAN+NA
Sbjct: 49 LHLASKEGHVKMVVELLHKEII--LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 106
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
++ TPL A NHLEV +++++ G EDG T L A + G+ +V+ L++
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 774 G--------------------------QVDVNAQ--DSGGWTPIIWAAEHKHIEVIRMLL 805
G Q D N G+TP+ AA ++++ V ++LL
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 806 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 865
RGA V T LH AS G+ + +LL+ + TPLH AAR +
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 866 CVLLFLSRGANPELRNKEG 884
+ L GA + + K G
Sbjct: 287 ISEILLDHGAPIQAKTKNG 305
Score = 86.3 bits (212), Expect = 2e-16
Identities = 59/184 (32%), Positives = 94/184 (51%), Gaps = 3/184 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ KQ +++ +L N +S Q TPLH AAQ+G E+ +LL AN N
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+K TPL H+ VA +++ G V + G T LH A+ GN+++V LL
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
Q DVNA+ G++P+ AA+ H +++ +LL GA ++ L A G ++
Sbjct: 724 -QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Query: 834 AEVL 837
+VL
Sbjct: 783 TDVL 786
Score = 79.7 bits (195), Expect = 2e-14
Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 9/242 (3%)
Query: 657 SVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDK 716
+ + G L K + L + +D N + Q+ LH A+++G V++ LL + K
Sbjct: 19 AARSGNLDKALDHLRNGVDIN--TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 717 QQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV 776
+ T L A + EV R +V G V ++ + G T L+ AA+ +LE+V LL G
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG-A 135
Query: 777 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAE 835
+ N G+TP+ A + H V+ L+ G T + + LH A+ A
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYG-----TKGKVRLPALHIAARNDDTRTAA 190
Query: 836 VLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERS 895
VLL + ++ G TPLHIAA + L L+RGA+ + G T + R
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 896 DV 897
+V
Sbjct: 251 NV 252
Score = 68.2 bits (165), Expect = 5e-11
Identities = 41/140 (29%), Positives = 73/140 (52%), Gaps = 1/140 (0%)
Query: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
+E D +T AA+ GNL+ L G VD+N + G + A++ H++++ LL
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNG-VDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 866
+ + T + N LH A+ G + L+N +++A + G TPL++AA+E++ +
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 867 VLLFLSRGANPELRNKEGDT 886
V L GAN + ++G T
Sbjct: 127 VKFLLENGANQNVATEDGFT 146
Score = 38.9 bits (89), Expect = 0.030
Identities = 38/165 (23%), Positives = 70/165 (42%), Gaps = 7/165 (4%)
Query: 778 VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVL 837
V +++ T + AA +++ L G D+ + LH AS G + L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 838 LNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDV 897
L+ L G+T LHIAA + V ++ GAN ++++G T + + +
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH- 123
Query: 898 WFALQLNRKLRLGVGNRAIRTE---KIICRDVARGYENVPIPCVN 939
L++ + L N+ + TE + + +G+ENV +N
Sbjct: 124 ---LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN 165
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 117 bits (293), Expect = 7e-26
Identities = 85/259 (32%), Positives = 133/259 (51%), Gaps = 9/259 (3%)
Query: 632 LEKALVIQESERRK----KLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 687
+E L + E E + K F P L+++ K G+++ L+L + PN ++ T
Sbjct: 516 VETVLALLEKEASQACMTKKGFTP--LHVAAKYGKVRVAELLLERDAHPNAAG--KNGLT 571
Query: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 747
PLH A +++I +LL G + ++ TPL A N +EVAR ++Q GG ++
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
G T LH AA+ G+ EMV+LLLS Q + N + G TP+ A+ H+ V +L+
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 867
G V T LH AS G+ + + LL + D++A G +PLH AA++ + D V
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 868 LLFLSRGANPELRNKEGDT 886
L L GA+P + +G T
Sbjct: 751 TLLLKNGASPNEVSSDGTT 769
Score = 115 bits (288), Expect = 3e-25
Identities = 81/250 (32%), Positives = 123/250 (49%), Gaps = 3/250 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ K+ ++ ++ LL + + +S TPLH A+ G + I LLQ GA+ N
Sbjct: 375 LHIACKKNHVR--VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ + TPL A H EVA+Y++Q V +K +D T LH AA+IG+ MV LLL
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE- 491
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
+ N + G TP+ AA H+E + LL + A + LH A+ G +
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
AE+LL +A +G TPLH+A + D V L L RG +P G T + +
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611
Query: 894 RSDVWFALQL 903
++ V A L
Sbjct: 612 QNQVEVARSL 621
Score = 108 bits (271), Expect = 2e-23
Identities = 79/279 (28%), Positives = 135/279 (48%), Gaps = 3/279 (1%)
Query: 628 GREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 687
G + + L+ + ++ K + L+ + + G + ++ +LLD+ P Q+ ++ +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHV-RISEILLDHGAP-IQAKTKNGLS 307
Query: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 747
P+H AAQ ++ +LLQ A I+ + TPL A H VA+ ++ +G S+
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
Query: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
+G T LH A K ++ ++ LLL TG ++A G TP+ A+ H+ +++ LL R
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 426
Query: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 867
GA +++ + LH A+ G +A+ LL + ++A TPLH AAR + + V
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
Query: 868 LLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRK 906
L L ANP L G T + V L L K
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Score = 104 bits (259), Expect = 6e-22
Identities = 75/246 (30%), Positives = 114/246 (46%), Gaps = 7/246 (2%)
Query: 654 LYLSVKQG--ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANI 711
L+++ + G E+ K +L ++ + DQ TPLH AA+ G + +LL+ AN
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ----TPLHCAARIGHTNMVKLLLENNANP 496
Query: 712 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 771
N TPL A H+E ++++ + G T LH AAK G + + LLL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 772 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
NA G TP+ A H +++++++LL RG LH A+
Sbjct: 557 ER-DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 832 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLT 891
+A LL +A + G TPLH+AA+E + + V L LS+ AN L NK G T L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Query: 892 PERSDV 897
+ V
Sbjct: 676 AQEGHV 681
Score = 96.3 bits (238), Expect = 2e-19
Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 30/259 (11%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+L+ K+G ++ V+ +L + ++ + T LH AA G E+ L+ GAN+NA
Sbjct: 49 LHLASKEGHVKMVVELLHKEII--LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 106
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
++ TPL A NHLEV +++++ G EDG T L A + G+ +V+ L++
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 774 G--------------------------QVDVNAQ--DSGGWTPIIWAAEHKHIEVIRMLL 805
G Q D N G+TP+ AA ++++ V ++LL
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 806 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 865
RGA V T LH AS G+ + +LL+ + TPLH AAR +
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 866 CVLLFLSRGANPELRNKEG 884
+ L GA + + K G
Sbjct: 287 ISEILLDHGAPIQAKTKNG 305
Score = 86.3 bits (212), Expect = 2e-16
Identities = 59/184 (32%), Positives = 94/184 (51%), Gaps = 3/184 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ KQ +++ +L N +S Q TPLH AAQ+G E+ +LL AN N
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+K TPL H+ VA +++ G V + G T LH A+ GN+++V LL
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
Q DVNA+ G++P+ AA+ H +++ +LL GA ++ L A G ++
Sbjct: 724 -QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Query: 834 AEVL 837
+VL
Sbjct: 783 TDVL 786
Score = 79.7 bits (195), Expect = 2e-14
Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 9/242 (3%)
Query: 657 SVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDK 716
+ + G L K + L + +D N + Q+ LH A+++G V++ LL + K
Sbjct: 19 AARSGNLDKALDHLRNGVDIN--TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 717 QQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV 776
+ T L A + EV R +V G V ++ + G T L+ AA+ +LE+V LL G
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG-A 135
Query: 777 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAE 835
+ N G+TP+ A + H V+ L+ G T + + LH A+ A
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYG-----TKGKVRLPALHIAARNDDTRTAA 190
Query: 836 VLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERS 895
VLL + ++ G TPLHIAA + L L+RGA+ + G T + R
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 896 DV 897
+V
Sbjct: 251 NV 252
Score = 68.2 bits (165), Expect = 5e-11
Identities = 41/140 (29%), Positives = 73/140 (52%), Gaps = 1/140 (0%)
Query: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
+E D +T AA+ GNL+ L G VD+N + G + A++ H++++ LL
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNG-VDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 866
+ + T + N LH A+ G + L+N +++A + G TPL++AA+E++ +
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 867 VLLFLSRGANPELRNKEGDT 886
V L GAN + ++G T
Sbjct: 127 VKFLLENGANQNVATEDGFT 146
Score = 38.9 bits (89), Expect = 0.030
Identities = 38/165 (23%), Positives = 70/165 (42%), Gaps = 7/165 (4%)
Query: 778 VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVL 837
V +++ T + AA +++ L G D+ + LH AS G + L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 838 LNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDV 897
L+ L G+T LHIAA + V ++ GAN ++++G T + + +
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH- 123
Query: 898 WFALQLNRKLRLGVGNRAIRTE---KIICRDVARGYENVPIPCVN 939
L++ + L N+ + TE + + +G+ENV +N
Sbjct: 124 ---LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN 165
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 117 bits (293), Expect = 7e-26
Identities = 85/259 (32%), Positives = 133/259 (51%), Gaps = 9/259 (3%)
Query: 632 LEKALVIQESERRK----KLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 687
+E L + E E + K F P L+++ K G+++ L+L + PN ++ T
Sbjct: 516 VETVLALLEKEASQACMTKKGFTP--LHVAAKYGKVRVAELLLERDAHPNAAG--KNGLT 571
Query: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 747
PLH A +++I +LL G + ++ TPL A N +EVAR ++Q GG ++
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
G T LH AA+ G+ EMV+LLLS Q + N + G TP+ A+ H+ V +L+
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 867
G V T LH AS G+ + + LL + D++A G +PLH AA++ + D V
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 868 LLFLSRGANPELRNKEGDT 886
L L GA+P + +G T
Sbjct: 751 TLLLKNGASPNEVSSDGTT 769
Score = 115 bits (288), Expect = 3e-25
Identities = 81/250 (32%), Positives = 123/250 (49%), Gaps = 3/250 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ K+ ++ ++ LL + + +S TPLH A+ G + I LLQ GA+ N
Sbjct: 375 LHIACKKNHVR--VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ + TPL A H EVA+Y++Q V +K +D T LH AA+IG+ MV LLL
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE- 491
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
+ N + G TP+ AA H+E + LL + A + LH A+ G +
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
AE+LL +A +G TPLH+A + D V L L RG +P G T + +
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611
Query: 894 RSDVWFALQL 903
++ V A L
Sbjct: 612 QNQVEVARSL 621
Score = 108 bits (271), Expect = 2e-23
Identities = 79/279 (28%), Positives = 135/279 (48%), Gaps = 3/279 (1%)
Query: 628 GREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 687
G + + L+ + ++ K + L+ + + G + ++ +LLD+ P Q+ ++ +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHV-RISEILLDHGAP-IQAKTKNGLS 307
Query: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 747
P+H AAQ ++ +LLQ A I+ + TPL A H VA+ ++ +G S+
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
Query: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
+G T LH A K ++ ++ LLL TG ++A G TP+ A+ H+ +++ LL R
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 426
Query: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 867
GA +++ + LH A+ G +A+ LL + ++A TPLH AAR + + V
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
Query: 868 LLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRK 906
L L ANP L G T + V L L K
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Score = 104 bits (259), Expect = 6e-22
Identities = 75/246 (30%), Positives = 114/246 (46%), Gaps = 7/246 (2%)
Query: 654 LYLSVKQG--ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANI 711
L+++ + G E+ K +L ++ + DQ TPLH AA+ G + +LL+ AN
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ----TPLHCAARIGHTNMVKLLLENNANP 496
Query: 712 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 771
N TPL A H+E ++++ + G T LH AAK G + + LLL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 772 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
NA G TP+ A H +++++++LL RG LH A+
Sbjct: 557 ER-DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 832 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLT 891
+A LL +A + G TPLH+AA+E + + V L LS+ AN L NK G T L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Query: 892 PERSDV 897
+ V
Sbjct: 676 AQEGHV 681
Score = 96.3 bits (238), Expect = 2e-19
Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 30/259 (11%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+L+ K+G ++ V+ +L + ++ + T LH AA G E+ L+ GAN+NA
Sbjct: 49 LHLASKEGHVKMVVELLHKEII--LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 106
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
++ TPL A NHLEV +++++ G EDG T L A + G+ +V+ L++
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 774 G--------------------------QVDVNAQ--DSGGWTPIIWAAEHKHIEVIRMLL 805
G Q D N G+TP+ AA ++++ V ++LL
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 806 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 865
RGA V T LH AS G+ + +LL+ + TPLH AAR +
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 866 CVLLFLSRGANPELRNKEG 884
+ L GA + + K G
Sbjct: 287 ISEILLDHGAPIQAKTKNG 305
Score = 86.3 bits (212), Expect = 2e-16
Identities = 59/184 (32%), Positives = 94/184 (51%), Gaps = 3/184 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ KQ +++ +L N +S Q TPLH AAQ+G E+ +LL AN N
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+K TPL H+ VA +++ G V + G T LH A+ GN+++V LL
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
Q DVNA+ G++P+ AA+ H +++ +LL GA ++ L A G ++
Sbjct: 724 -QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Query: 834 AEVL 837
+VL
Sbjct: 783 TDVL 786
Score = 79.7 bits (195), Expect = 2e-14
Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 9/242 (3%)
Query: 657 SVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDK 716
+ + G L K + L + +D N + Q+ LH A+++G V++ LL + K
Sbjct: 19 AARSGNLDKALDHLRNGVDIN--TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 717 QQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV 776
+ T L A + EV R +V G V ++ + G T L+ AA+ +LE+V LL G
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG-A 135
Query: 777 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAE 835
+ N G+TP+ A + H V+ L+ G T + + LH A+ A
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYG-----TKGKVRLPALHIAARNDDTRTAA 190
Query: 836 VLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERS 895
VLL + ++ G TPLHIAA + L L+RGA+ + G T + R
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 896 DV 897
+V
Sbjct: 251 NV 252
Score = 68.2 bits (165), Expect = 5e-11
Identities = 41/140 (29%), Positives = 73/140 (52%), Gaps = 1/140 (0%)
Query: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
+E D +T AA+ GNL+ L G VD+N + G + A++ H++++ LL
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNG-VDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 866
+ + T + N LH A+ G + L+N +++A + G TPL++AA+E++ +
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 867 VLLFLSRGANPELRNKEGDT 886
V L GAN + ++G T
Sbjct: 127 VKFLLENGANQNVATEDGFT 146
Score = 38.9 bits (89), Expect = 0.030
Identities = 38/165 (23%), Positives = 70/165 (42%), Gaps = 7/165 (4%)
Query: 778 VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVL 837
V +++ T + AA +++ L G D+ + LH AS G + L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 838 LNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDV 897
L+ L G+T LHIAA + V ++ GAN ++++G T + + +
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH- 123
Query: 898 WFALQLNRKLRLGVGNRAIRTE---KIICRDVARGYENVPIPCVN 939
L++ + L N+ + TE + + +G+ENV +N
Sbjct: 124 ---LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN 165
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 117 bits (293), Expect = 7e-26
Identities = 85/259 (32%), Positives = 133/259 (51%), Gaps = 9/259 (3%)
Query: 632 LEKALVIQESERRK----KLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 687
+E L + E E + K F P L+++ K G+++ L+L + PN ++ T
Sbjct: 516 VETVLALLEKEASQACMTKKGFTP--LHVAAKYGKVRVAELLLERDAHPNAAG--KNGLT 571
Query: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 747
PLH A +++I +LL G + ++ TPL A N +EVAR ++Q GG ++
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
G T LH AA+ G+ EMV+LLLS Q + N + G TP+ A+ H+ V +L+
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 867
G V T LH AS G+ + + LL + D++A G +PLH AA++ + D V
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 868 LLFLSRGANPELRNKEGDT 886
L L GA+P + +G T
Sbjct: 751 TLLLKNGASPNEVSSDGTT 769
Score = 115 bits (288), Expect = 3e-25
Identities = 81/250 (32%), Positives = 123/250 (49%), Gaps = 3/250 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ K+ ++ ++ LL + + +S TPLH A+ G + I LLQ GA+ N
Sbjct: 375 LHIACKKNHVR--VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ + TPL A H EVA+Y++Q V +K +D T LH AA+IG+ MV LLL
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE- 491
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
+ N + G TP+ AA H+E + LL + A + LH A+ G +
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
AE+LL +A +G TPLH+A + D V L L RG +P G T + +
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611
Query: 894 RSDVWFALQL 903
++ V A L
Sbjct: 612 QNQVEVARSL 621
Score = 108 bits (271), Expect = 2e-23
Identities = 79/279 (28%), Positives = 135/279 (48%), Gaps = 3/279 (1%)
Query: 628 GREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT 687
G + + L+ + ++ K + L+ + + G + ++ +LLD+ P Q+ ++ +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHV-RISEILLDHGAP-IQAKTKNGLS 307
Query: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 747
P+H AAQ ++ +LLQ A I+ + TPL A H VA+ ++ +G S+
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
Query: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
+G T LH A K ++ ++ LLL TG ++A G TP+ A+ H+ +++ LL R
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 426
Query: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 867
GA +++ + LH A+ G +A+ LL + ++A TPLH AAR + + V
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
Query: 868 LLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRK 906
L L ANP L G T + V L L K
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Score = 104 bits (259), Expect = 6e-22
Identities = 75/246 (30%), Positives = 114/246 (46%), Gaps = 7/246 (2%)
Query: 654 LYLSVKQG--ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANI 711
L+++ + G E+ K +L ++ + DQ TPLH AA+ G + +LL+ AN
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ----TPLHCAARIGHTNMVKLLLENNANP 496
Query: 712 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 771
N TPL A H+E ++++ + G T LH AAK G + + LLL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 772 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
NA G TP+ A H +++++++LL RG LH A+
Sbjct: 557 ER-DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 832 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLT 891
+A LL +A + G TPLH+AA+E + + V L LS+ AN L NK G T L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Query: 892 PERSDV 897
+ V
Sbjct: 676 AQEGHV 681
Score = 96.3 bits (238), Expect = 2e-19
Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 30/259 (11%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+L+ K+G ++ V+ +L + ++ + T LH AA G E+ L+ GAN+NA
Sbjct: 49 LHLASKEGHVKMVVELLHKEII--LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 106
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
++ TPL A NHLEV +++++ G EDG T L A + G+ +V+ L++
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 774 G--------------------------QVDVNAQ--DSGGWTPIIWAAEHKHIEVIRMLL 805
G Q D N G+TP+ AA ++++ V ++LL
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 806 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 865
RGA V T LH AS G+ + +LL+ + TPLH AAR +
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 866 CVLLFLSRGANPELRNKEG 884
+ L GA + + K G
Sbjct: 287 ISEILLDHGAPIQAKTKNG 305
Score = 86.3 bits (212), Expect = 2e-16
Identities = 59/184 (32%), Positives = 94/184 (51%), Gaps = 3/184 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ KQ +++ +L N +S Q TPLH AAQ+G E+ +LL AN N
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+K TPL H+ VA +++ G V + G T LH A+ GN+++V LL
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
Q DVNA+ G++P+ AA+ H +++ +LL GA ++ L A G ++
Sbjct: 724 -QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Query: 834 AEVL 837
+VL
Sbjct: 783 TDVL 786
Score = 79.7 bits (195), Expect = 2e-14
Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 9/242 (3%)
Query: 657 SVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDK 716
+ + G L K + L + +D N + Q+ LH A+++G V++ LL + K
Sbjct: 19 AARSGNLDKALDHLRNGVDIN--TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 717 QQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV 776
+ T L A + EV R +V G V ++ + G T L+ AA+ +LE+V LL G
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG-A 135
Query: 777 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAE 835
+ N G+TP+ A + H V+ L+ G T + + LH A+ A
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYG-----TKGKVRLPALHIAARNDDTRTAA 190
Query: 836 VLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERS 895
VLL + ++ G TPLHIAA + L L+RGA+ + G T + R
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 896 DV 897
+V
Sbjct: 251 NV 252
Score = 68.2 bits (165), Expect = 5e-11
Identities = 41/140 (29%), Positives = 73/140 (52%), Gaps = 1/140 (0%)
Query: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
+E D +T AA+ GNL+ L G VD+N + G + A++ H++++ LL
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNG-VDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 866
+ + T + N LH A+ G + L+N +++A + G TPL++AA+E++ +
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 867 VLLFLSRGANPELRNKEGDT 886
V L GAN + ++G T
Sbjct: 127 VKFLLENGANQNVATEDGFT 146
Score = 38.9 bits (89), Expect = 0.030
Identities = 38/165 (23%), Positives = 70/165 (42%), Gaps = 7/165 (4%)
Query: 778 VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVL 837
V +++ T + AA +++ L G D+ + LH AS G + L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 838 LNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDV 897
L+ L G+T LHIAA + V ++ GAN ++++G T + + +
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH- 123
Query: 898 WFALQLNRKLRLGVGNRAIRTE---KIICRDVARGYENVPIPCVN 939
L++ + L N+ + TE + + +G+ENV +N
Sbjct: 124 ---LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN 165
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 117 bits (293), Expect = 7e-26
Identities = 77/252 (30%), Positives = 130/252 (51%), Gaps = 6/252 (2%)
Query: 686 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 745
RTPLH AA KG + + +LL+AG +++ D +T L A V + E+ ++ G +
Sbjct: 43 RTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALD 102
Query: 746 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL 805
+++DG+T LH A+ G + LL+ G +V A++ G T + A ++ H + R+LL
Sbjct: 103 RQDKDGNTALHEASWHGFSQSAKLLVKAG-ANVLAKNKAGNTALHLACQNSHSQSTRVLL 161
Query: 806 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 865
G+ L +N + CLH A+ +I +LL A C +H N GDT LH+AA ++
Sbjct: 162 LAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKK 221
Query: 866 CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRK---LRLGVGNRAIRTEKII 922
+ L GA+ + N G T + ++ AL L + LR G R++R ++
Sbjct: 222 VAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRG-RSLRKKRER 280
Query: 923 CRDVARGYENVP 934
++ R ++VP
Sbjct: 281 LKEERRA-QSVP 291
Score = 65.9 bits (159), Expect = 2e-10
Identities = 45/139 (32%), Positives = 69/139 (49%), Gaps = 4/139 (2%)
Query: 758 AAKIGNLEMVSLLLSTG-QVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDN 816
AA G E V L++ G +V V G TP+ AA H+ V+++LL G D+ + D+
Sbjct: 17 AAYKGQTENVVQLINKGARVAVTKH---GRTPLHLAANKGHLPVVQILLKAGCDLDVQDD 73
Query: 817 EENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGAN 876
+ LH A+ G+ I L++ C L + G+T LH A+ + L + GAN
Sbjct: 74 GDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGAN 133
Query: 877 PELRNKEGDTAWDLTPERS 895
+NK G+TA L + S
Sbjct: 134 VLAKNKAGNTALHLACQNS 152
Score = 60.1 bits (144), Expect = 1e-08
Identities = 43/142 (30%), Positives = 66/142 (46%), Gaps = 2/142 (1%)
Query: 670 LLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNN 729
LL N + ++ T LH A Q + VLL AG+ + + T L A N
Sbjct: 126 LLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYN 185
Query: 730 HLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPI 789
HL + R ++ V+ K + G T LH AA + + ++ +LL G D ++ G TP+
Sbjct: 186 HLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAG-ADTTIVNNAGQTPL 244
Query: 790 IWAAEHKHIEVIRMLLTRGADV 811
A H + EV +LLT+ V
Sbjct: 245 ETARYHNNPEV-ALLLTKAPQV 265
Score = 37.0 bits (84), Expect = 0.11
Identities = 23/68 (33%), Positives = 35/68 (51%)
Query: 667 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 726
I+ LL + Q+ T LH AA ++ +LL+AGA+ V+ +TPL A
Sbjct: 189 IIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETAR 248
Query: 727 VNNHLEVA 734
+N+ EVA
Sbjct: 249 YHNNPEVA 256
>gi|224177469 SET domain, bifurcated 1 isoform 2 [Homo sapiens]
Length = 1290
Score = 112 bits (280), Expect = 2e-24
Identities = 64/180 (35%), Positives = 97/180 (53%), Gaps = 14/180 (7%)
Query: 925 DVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDC-SSS 983
D+ G E+VP+ CVN +D P P+ Y E + I+ L C C D C S
Sbjct: 681 DITYGKEDVPLSCVNEIDTTPPPQ-VAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKS 739
Query: 984 NCLCGQLSIRCWYDKDGRLLQ-----EFNKIE---PPLIFECNQACSCWRN-CKNRVVQS 1034
C C QL+I+ G + ++ ++E P ++ECN+ C C N C NR+VQ
Sbjct: 740 KCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQH 799
Query: 1035 GIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEAD---VREDDSYLFDLDN 1091
G++VRLQL++T GWG+R L I +G+F+C Y G++++D AD + D Y +LD+
Sbjct: 800 GLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDH 859
Score = 77.0 bits (188), Expect = 1e-13
Identities = 38/86 (44%), Positives = 53/86 (61%), Gaps = 3/86 (3%)
Query: 1093 DGEVYC--IDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEEL 1150
DGE C IDA+ GN+ R++NH C PN+ VF+ DLRFP +AFF+S+ IR G EL
Sbjct: 1202 DGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTEL 1260
Query: 1151 GFDYGDRFWDIKSKYFTCQCGSEKCK 1176
+DY ++ K C CG+ +C+
Sbjct: 1261 TWDYNYEVGSVEGKELLCCCGAIECR 1286
>gi|224177467 SET domain, bifurcated 1 isoform 1 [Homo sapiens]
Length = 1291
Score = 112 bits (280), Expect = 2e-24
Identities = 64/180 (35%), Positives = 97/180 (53%), Gaps = 14/180 (7%)
Query: 925 DVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDC-SSS 983
D+ G E+VP+ CVN +D P P+ Y E + I+ L C C D C S
Sbjct: 681 DITYGKEDVPLSCVNEIDTTPPPQ-VAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKS 739
Query: 984 NCLCGQLSIRCWYDKDGRLLQ-----EFNKIE---PPLIFECNQACSCWRN-CKNRVVQS 1034
C C QL+I+ G + ++ ++E P ++ECN+ C C N C NR+VQ
Sbjct: 740 KCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQH 799
Query: 1035 GIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEAD---VREDDSYLFDLDN 1091
G++VRLQL++T GWG+R L I +G+F+C Y G++++D AD + D Y +LD+
Sbjct: 800 GLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDH 859
Score = 80.9 bits (198), Expect = 7e-15
Identities = 38/86 (44%), Positives = 53/86 (61%), Gaps = 2/86 (2%)
Query: 1093 DGEVYC--IDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEEL 1150
DGE C IDA+ GN+ R++NH C PN+ VF+ DLRFP +AFF+S+ IR G EL
Sbjct: 1202 DGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTEL 1261
Query: 1151 GFDYGDRFWDIKSKYFTCQCGSEKCK 1176
+DY ++ K C CG+ +C+
Sbjct: 1262 TWDYNYEVGSVEGKELLCCCGAIECR 1287
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 112 bits (279), Expect = 3e-24
Identities = 79/236 (33%), Positives = 116/236 (49%), Gaps = 4/236 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+ + G Q V L+L N SD Q TPLH AAQ E V L+ + +
Sbjct: 259 LHWAALLGHAQIVHLLLERNKSGTIPSDSQGA-TPLHYAAQSNFAETVKVFLKHPSVKDD 317
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEED--GSTCLHHAAKIGNLEMVSLLL 771
D + RT M A +V R M+ + D G T LH AA G++ V LLL
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377
Query: 772 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
V+A D TP+ A E H +VI+ L+ GA V L D + + LHWA+ G+A
Sbjct: 378 ENN-AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA 436
Query: 832 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
+ ++L+ + + + +Y G TPL AA Y +C+ + + A+P +++KEG TA
Sbjct: 437 DVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTA 492
Score = 92.8 bits (229), Expect = 2e-18
Identities = 63/216 (29%), Positives = 103/216 (47%), Gaps = 5/216 (2%)
Query: 662 ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTP 721
++ + +L L ++D N T LHAAA G V +LL+ A ++A D + TP
Sbjct: 336 DVLRTMLSLKSDIDINMADKYGG--TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTP 393
Query: 722 LMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQ 781
L A H +V + +++ G V ++DG + LH AA GN ++ +L+ +++ N Q
Sbjct: 394 LFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEN-KINPNVQ 452
Query: 782 DSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR 841
D G TP+ AA +I + +L+ AD + D E LHW+ G ++LL+
Sbjct: 453 DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFA 512
Query: 842 CDLHAV--NYHGDTPLHIAARESYHDCVLLFLSRGA 875
+ + N TPL A H+ + L GA
Sbjct: 513 AFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 73.2 bits (178), Expect = 1e-12
Identities = 75/301 (24%), Positives = 122/301 (40%), Gaps = 46/301 (15%)
Query: 631 ALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLH 690
AL++ +V + + K+ +F L V L +L D N S+RT LH
Sbjct: 29 ALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN--KTDHSQRTALH 86
Query: 691 AAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ--RGGCVYSKE 748
AAQKG+ +LL AN D ++ TPL + + +++ G V +++
Sbjct: 87 LAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQD 146
Query: 749 EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKH---IEVIRMLL 805
++ T LH +A N E V LL+ ++ D G P+ WAA HK + +R +L
Sbjct: 147 KNKQTALHWSAYYNNPEHVKLLIKHDS-NIGIPDVEGKIPLHWAANHKDPSAVHTVRCIL 205
Query: 806 T-------------------------------------RGADVTLTDNEENICLHWASFT 828
++T DN LHWA+
Sbjct: 206 DAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALL 265
Query: 829 GSAAIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
G A I +LL + + G TPLH AA+ ++ + V +FL + + + EG T+
Sbjct: 266 GHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTS 325
Query: 888 W 888
+
Sbjct: 326 F 326
Score = 70.9 bits (172), Expect = 7e-12
Identities = 60/215 (27%), Positives = 93/215 (43%), Gaps = 9/215 (4%)
Query: 670 LLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHV---LLQAGAN---INAVDKQQRTPLM 723
LL D N + PLH AA H +L A +N D + RTPL
Sbjct: 167 LLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLH 226
Query: 724 EAVVNNHLEVARYMVQRGGC-VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQD 782
AV + ++ V + C + S + T LH AA +G+ ++V LLL + D
Sbjct: 227 FAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSD 286
Query: 783 SGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR- 841
S G TP+ +AA+ E +++ L + +D E WA+ GS + +L+ +
Sbjct: 287 SQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKS 346
Query: 842 -CDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA 875
D++ + +G T LH AA + V L L A
Sbjct: 347 DIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381
Score = 52.8 bits (125), Expect = 2e-06
Identities = 37/138 (26%), Positives = 61/138 (44%), Gaps = 4/138 (2%)
Query: 755 LHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLT 814
+H AA G+ + L+ + +D G TP+++ ++ LL GADV T
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 815 DNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRG 874
D+ + LH A+ G+ ++LL R + + TPLH+ R C+ L L
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 875 ANPEL----RNKEGDTAW 888
A E+ +NK+ W
Sbjct: 138 APGEVDTQDKNKQTALHW 155
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 112 bits (279), Expect = 3e-24
Identities = 79/236 (33%), Positives = 116/236 (49%), Gaps = 4/236 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+ + G Q V L+L N SD Q TPLH AAQ E V L+ + +
Sbjct: 259 LHWAALLGHAQIVHLLLERNKSGTIPSDSQGA-TPLHYAAQSNFAETVKVFLKHPSVKDD 317
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEED--GSTCLHHAAKIGNLEMVSLLL 771
D + RT M A +V R M+ + D G T LH AA G++ V LLL
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377
Query: 772 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
V+A D TP+ A E H +VI+ L+ GA V L D + + LHWA+ G+A
Sbjct: 378 ENN-AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA 436
Query: 832 AIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
+ ++L+ + + + +Y G TPL AA Y +C+ + + A+P +++KEG TA
Sbjct: 437 DVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTA 492
Score = 92.8 bits (229), Expect = 2e-18
Identities = 63/216 (29%), Positives = 103/216 (47%), Gaps = 5/216 (2%)
Query: 662 ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTP 721
++ + +L L ++D N T LHAAA G V +LL+ A ++A D + TP
Sbjct: 336 DVLRTMLSLKSDIDINMADKYGG--TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTP 393
Query: 722 LMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQ 781
L A H +V + +++ G V ++DG + LH AA GN ++ +L+ +++ N Q
Sbjct: 394 LFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEN-KINPNVQ 452
Query: 782 DSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR 841
D G TP+ AA +I + +L+ AD + D E LHW+ G ++LL+
Sbjct: 453 DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFA 512
Query: 842 CDLHAV--NYHGDTPLHIAARESYHDCVLLFLSRGA 875
+ + N TPL A H+ + L GA
Sbjct: 513 AFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 73.2 bits (178), Expect = 1e-12
Identities = 75/301 (24%), Positives = 122/301 (40%), Gaps = 46/301 (15%)
Query: 631 ALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLH 690
AL++ +V + + K+ +F L V L +L D N S+RT LH
Sbjct: 29 ALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN--KTDHSQRTALH 86
Query: 691 AAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ--RGGCVYSKE 748
AAQKG+ +LL AN D ++ TPL + + +++ G V +++
Sbjct: 87 LAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQD 146
Query: 749 EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKH---IEVIRMLL 805
++ T LH +A N E V LL+ ++ D G P+ WAA HK + +R +L
Sbjct: 147 KNKQTALHWSAYYNNPEHVKLLIKHDS-NIGIPDVEGKIPLHWAANHKDPSAVHTVRCIL 205
Query: 806 T-------------------------------------RGADVTLTDNEENICLHWASFT 828
++T DN LHWA+
Sbjct: 206 DAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALL 265
Query: 829 GSAAIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
G A I +LL + + G TPLH AA+ ++ + V +FL + + + EG T+
Sbjct: 266 GHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTS 325
Query: 888 W 888
+
Sbjct: 326 F 326
Score = 70.9 bits (172), Expect = 7e-12
Identities = 60/215 (27%), Positives = 93/215 (43%), Gaps = 9/215 (4%)
Query: 670 LLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHV---LLQAGAN---INAVDKQQRTPLM 723
LL D N + PLH AA H +L A +N D + RTPL
Sbjct: 167 LLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLH 226
Query: 724 EAVVNNHLEVARYMVQRGGC-VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQD 782
AV + ++ V + C + S + T LH AA +G+ ++V LLL + D
Sbjct: 227 FAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSD 286
Query: 783 SGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR- 841
S G TP+ +AA+ E +++ L + +D E WA+ GS + +L+ +
Sbjct: 287 SQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKS 346
Query: 842 -CDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA 875
D++ + +G T LH AA + V L L A
Sbjct: 347 DIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381
Score = 52.8 bits (125), Expect = 2e-06
Identities = 37/138 (26%), Positives = 61/138 (44%), Gaps = 4/138 (2%)
Query: 755 LHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLT 814
+H AA G+ + L+ + +D G TP+++ ++ LL GADV T
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 815 DNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRG 874
D+ + LH A+ G+ ++LL R + + TPLH+ R C+ L L
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 875 ANPEL----RNKEGDTAW 888
A E+ +NK+ W
Sbjct: 138 APGEVDTQDKNKQTALHW 155
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 110 bits (275), Expect = 8e-24
Identities = 107/375 (28%), Positives = 161/375 (42%), Gaps = 48/375 (12%)
Query: 553 GVTP-PAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLT 611
GV P PAG+ + P S P + +S PS+ P LA++ +++G S T
Sbjct: 115 GVAPNPAGSGSNNSPSSSSS-PTSSSSSSPSS-----------PGSSLAESPEAAGVSST 162
Query: 612 LP--NGGCLSAVGLPLGPG--REALE----------KALVIQESERRKKLRFHPRQLYLS 657
P G G+P G RE LE K LV + K + + L
Sbjct: 163 APLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGR-KSSPLH 221
Query: 658 VKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQ 717
G +K ++ L + N + PLH A G E+ +LL GA+ NA D
Sbjct: 222 FAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNW 281
Query: 718 QRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLH--------------------H 757
TPL EA + ++V ++Q G + DG + L
Sbjct: 282 NYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLE 341
Query: 758 AAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNE 817
AA+ GN E + LL+ V+ +A D TP+ AA + + ++++LL GADV D
Sbjct: 342 AARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKG 401
Query: 818 ENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 877
+ LH A G + E+LL ++A++ TPLH AA ++ + L LS GA+P
Sbjct: 402 GLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADP 461
Query: 878 ELRNKEGDTAWDLTP 892
L N G +A D+ P
Sbjct: 462 TLVNCHGKSAVDMAP 476
Score = 100 bits (250), Expect = 6e-21
Identities = 69/223 (30%), Positives = 102/223 (45%), Gaps = 20/223 (8%)
Query: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 747
PLH A G E+ +L++ GA++N D + TPL EA E+ + +++ G K
Sbjct: 720 PLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKK 779
Query: 748 EEDGST--------------------CLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWT 787
DG+T L AAK G L V L + ++ T
Sbjct: 780 NRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNST 839
Query: 788 PIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 847
P+ AA + ++EV LL GADV D I LH A+ G IA +L+ ++A
Sbjct: 840 PLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNAT 899
Query: 848 NYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDL 890
+ TPLH AA++ L L+ GA+P ++N+EG T DL
Sbjct: 900 DKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDL 942
Score = 99.0 bits (245), Expect = 2e-20
Identities = 86/317 (27%), Positives = 131/317 (41%), Gaps = 46/317 (14%)
Query: 664 QKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLM 723
+K + LL N + TPLH AA++ ++ VL + GA +NA+D +T L
Sbjct: 537 RKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALH 596
Query: 724 EAVVNNHLEVARYMVQRGGCVYSKEEDGSTC--------------------------LHH 757
A + HL+ R ++ G G T L
Sbjct: 597 RAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLE 656
Query: 758 AAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNE 817
A+K G+LE V L S+ V+ + TP+ +AA + + V+ LL GADV D
Sbjct: 657 ASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKG 716
Query: 818 ENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 877
+ LH A G +AE+L+ ++ + TPLH AA + ++ L L GA+P
Sbjct: 717 GLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADP 776
Query: 878 ELRNKEGDTAWDLTPE---------RSDVWFALQLNRKLRLGVGNRAIRTEKIICRD--- 925
+N++G+T DL E R D L +K L + E I CRD
Sbjct: 777 TKKNRDGNTPLDLVKEGDTDIQDLLRGDA-ALLDAAKKGCLARVQKLCTPENINCRDTQG 835
Query: 926 -------VARGYENVPI 935
+A GY N+ +
Sbjct: 836 RNSTPLHLAAGYNNLEV 852
Score = 68.2 bits (165), Expect = 5e-11
Identities = 38/113 (33%), Positives = 62/113 (54%), Gaps = 1/113 (0%)
Query: 677 NFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARY 736
N + Q TPLH AA ++E+ LL+ GA++NA DK PL A H+++A
Sbjct: 829 NCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAAL 888
Query: 737 MVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPI 789
+++ CV + ++ T LH AA+ G ++ +LLL+ G D ++ G TP+
Sbjct: 889 LIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTMKNQEGQTPL 940
Score = 65.1 bits (157), Expect = 4e-10
Identities = 78/319 (24%), Positives = 132/319 (41%), Gaps = 40/319 (12%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+L+ ++ V L+L D + + + PLH A G E+ +LL+ GA +NA
Sbjct: 373 LHLAAGYNRVRIVQLLLQHGADVH--AKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA 430
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTC------------------- 754
+D Q TPL EA N +EV ++ G G +
Sbjct: 431 MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKG 490
Query: 755 --LHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTP--IIWAAEHKHIEVIRMLLTRGAD 810
L AA+ +L V L+ ++ S + + K +V +LL +GA+
Sbjct: 491 HSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGAN 550
Query: 811 VTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLF 870
V + + LH A+ + EVL ++A++ G T LH AA + L
Sbjct: 551 VNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610
Query: 871 LSRGANPELRNKEGDTAWDL------------TPER-SDV-WFALQLNRKLRLGVGNRAI 916
LS G++P + + +G TA + TP R SDV + L+ ++ L +
Sbjct: 611 LSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLC 670
Query: 917 RTEKIICRDVARGYENVPI 935
++ + CRD+ G + P+
Sbjct: 671 SSQNVNCRDL-EGRHSTPL 688
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 110 bits (275), Expect = 8e-24
Identities = 67/198 (33%), Positives = 101/198 (51%), Gaps = 1/198 (0%)
Query: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 746
TPL AA +G V++ +LL+ GA+++ D RTPL+ A H V ++ G V S
Sbjct: 750 TPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS 809
Query: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
+ +G T L A+ GN+E+V LL G +D N +D GWTP+ AA H + L+
Sbjct: 810 IDSEGRTVLSIASAQGNVEVVRTLLDRG-LDENHRDDAGWTPLHMAAFEGHRLICEALIE 868
Query: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 866
+GA DN+ I AS G ++LL + ++ Y G L +AA E + D
Sbjct: 869 QGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDI 928
Query: 867 VLLFLSRGANPELRNKEG 884
V L S GA+ ++ +G
Sbjct: 929 VELLFSHGADVNCKDADG 946
Score = 99.8 bits (247), Expect = 1e-20
Identities = 61/195 (31%), Positives = 100/195 (51%), Gaps = 1/195 (0%)
Query: 693 AQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGS 752
A KG + +L+ GA ++ DK TPL+ A H++V +++ G V + +G
Sbjct: 723 ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR 782
Query: 753 TCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVT 812
T L AA +G+ +V+ LL G V++ DS G T + A+ ++EV+R LL RG D
Sbjct: 783 TPLLAAASMGHASVVNTLLFWGAA-VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN 841
Query: 813 LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 872
D+ LH A+F G I E L+ + ++ G P +A++E ++DCV + L
Sbjct: 842 HRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE 901
Query: 873 RGANPELRNKEGDTA 887
+N + R +G A
Sbjct: 902 NKSNIDQRGYDGRNA 916
Score = 97.1 bits (240), Expect = 9e-20
Identities = 76/267 (28%), Positives = 122/267 (45%), Gaps = 36/267 (13%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L ++ QG ++ V +L LD N + D + TPLH AA +G IC L++ GA N
Sbjct: 818 LSIASAQGNVEVVRTLLDRGLDENHRDD--AGWTPLHMAAFEGHRLICEALIEQGARTNE 875
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+D R P + A H + + +++ + + DG L AA G+ ++V LL S
Sbjct: 876 IDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSH 935
Query: 774 GQVDVNAQDSGGW-TPIIWAAEHK--------------------------------HIEV 800
G DVN +D+ G T I A E++ H+E+
Sbjct: 936 G-ADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEM 994
Query: 801 IRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAAR 860
+++L+ ADV DNE+ L A++ G + ++L+ + G T L IAA+
Sbjct: 995 VQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQ 1054
Query: 861 ESYHDCVLLFLSRGANPELRNKEGDTA 887
E + D V + L GA+P ++ G TA
Sbjct: 1055 EGHIDVVQVLLEHGADPNHADQFGRTA 1081
Score = 94.4 bits (233), Expect = 6e-19
Identities = 74/230 (32%), Positives = 112/230 (48%), Gaps = 7/230 (3%)
Query: 662 ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTP 721
E + I LLDN Q D RT L AA GS+++ ++L+ GA++ D TP
Sbjct: 523 EREDSIRTLLDNGASVNQCDSNG-RTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTP 581
Query: 722 LMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQ 781
L A H +V ++ G + ++DG T L AA G+ E+VS LL G V V+
Sbjct: 582 LTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAG-VKVDCA 640
Query: 782 DSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR 841
D+ T + AA H +++ LL GA+V DNE L A++ G I E LL+
Sbjct: 641 DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
Query: 842 CDLHAVNYHGDTPLHIA-----ARESYHDCVLLFLSRGANPELRNKEGDT 886
+++ + G T L +A A + + V L + RGA + +K+G T
Sbjct: 701 AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMT 750
Score = 93.2 bits (230), Expect = 1e-18
Identities = 72/249 (28%), Positives = 112/249 (44%), Gaps = 8/249 (3%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L L+ +QG + V ++ N Q T L +AA G E+ LL AG ++
Sbjct: 582 LTLAARQGHTKVVNCLI--GCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDC 639
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
D RT L A H ++ ++Q G V + +G T L AA +G+ E+V LL
Sbjct: 640 ADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDH 699
Query: 774 GQVDVNAQDSGGWTPIIWAA-----EHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 828
G +VN +D G T + AA H V+ +L+ RGA+V D + L A++
Sbjct: 700 G-AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYE 758
Query: 829 GSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAW 888
G + ++LL D+ + +G TPL AA + V L GA + + EG T
Sbjct: 759 GHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVL 818
Query: 889 DLTPERSDV 897
+ + +V
Sbjct: 819 SIASAQGNV 827
Score = 92.4 bits (228), Expect = 2e-18
Identities = 73/270 (27%), Positives = 128/270 (47%), Gaps = 3/270 (1%)
Query: 618 LSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPN 677
++A+ +P G ++ L+ + +E + L ++ +G + V L+L D +
Sbjct: 716 VAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD 775
Query: 678 FQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYM 737
+ + RTPL AAA G + + LL GA ++++D + RT L A ++EV R +
Sbjct: 776 HTDN--NGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
Query: 738 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKH 797
+ RG +++ G T LH AA G+ + L+ G N D+ G P I A++ H
Sbjct: 834 LDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG-ARTNEIDNDGRIPFILASQEGH 892
Query: 798 IEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 857
+ +++LL +++ + L A+ G I E+L + D++ + G L+I
Sbjct: 893 YDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYI 952
Query: 858 AARESYHDCVLLFLSRGANPELRNKEGDTA 887
A E+ FL GAN E + EG TA
Sbjct: 953 LALENQLTMAEYFLENGANVEASDAEGRTA 982
Score = 91.7 bits (226), Expect = 4e-18
Identities = 65/240 (27%), Positives = 114/240 (47%), Gaps = 2/240 (0%)
Query: 637 VIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKG 696
+I++ R ++ R ++ Q + +LL+N N R L AA +G
Sbjct: 866 LIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKS-NIDQRGYDGRNALRVAALEG 924
Query: 697 SVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLH 756
+I +L GA++N D R L + N L +A Y ++ G V + + +G T LH
Sbjct: 925 HRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALH 984
Query: 757 HAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDN 816
+ G++EMV +L++ DVNA D+ + + AA H++V+++L+ GA V T N
Sbjct: 985 VSCWQGHMEMVQVLIAY-HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCN 1043
Query: 817 EENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGAN 876
+ L A+ G + +VLL D + + G T + +AA+ + + L GA+
Sbjct: 1044 QGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103
Score = 86.3 bits (212), Expect = 2e-16
Identities = 57/189 (30%), Positives = 96/189 (50%), Gaps = 3/189 (1%)
Query: 699 EICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHA 758
E+ +L++AGA++N+ D + + +A+ + R ++ G V + +G T L +A
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLANA 552
Query: 759 AKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEE 818
A G+L++V+LL+S G D+ +D+ G TP+ AA H +V+ L+ GA++ TD +
Sbjct: 553 AYSGSLDVVNLLVSRG-ADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
Query: 819 NICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPE 878
L A++ G + LL A + + T L AA + D VL L GA
Sbjct: 612 WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
Query: 879 LRNKEGDTA 887
+ EG TA
Sbjct: 672 KADNEGRTA 680
Score = 80.5 bits (197), Expect = 9e-15
Identities = 57/184 (30%), Positives = 86/184 (46%), Gaps = 1/184 (0%)
Query: 704 LLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGN 763
LL GA++N D RT L A + L+V +V RG + ++ G T L AA+ G+
Sbjct: 531 LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590
Query: 764 LEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLH 823
++V+ L+ G ++N D GWT + AA H EV+ LL G V D + L
Sbjct: 591 TKVVNCLIGCG-ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALR 649
Query: 824 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 883
A++ G I LL +++ + G T L AA + + V L GA + +
Sbjct: 650 AAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVD 709
Query: 884 GDTA 887
G TA
Sbjct: 710 GRTA 713
Score = 57.4 bits (137), Expect = 8e-08
Identities = 34/126 (26%), Positives = 68/126 (53%), Gaps = 2/126 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L++S QG ++ V +++ + D N ++ KR+ L +AA +G V++ +L++ GA ++
Sbjct: 983 LHVSCWQGHMEMVQVLIAYHADVNAADNE--KRSALQSAAWQGHVKVVQLLIEHGAVVDH 1040
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
Q T L A H++V + +++ G ++ G T + AAK G+ +++ LL
Sbjct: 1041 TCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKY 1100
Query: 774 GQVDVN 779
G +N
Sbjct: 1101 GASSLN 1106
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 109 bits (273), Expect = 1e-23
Identities = 87/281 (30%), Positives = 134/281 (47%), Gaps = 4/281 (1%)
Query: 610 LTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILM 669
L L +G L + L + G+E K L++ + R L+++V++ V L+
Sbjct: 433 LALDSGASL--LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
Query: 670 LLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNN 729
L + N + + Q T LH AAQ G +LL+ A++N VD + RTP+ A +
Sbjct: 491 LARKISVNAKDEDQW--TALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHG 548
Query: 730 HLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPI 789
+ R +++RG V + +D LH+AA G+L +V LL V VNAQ G TP+
Sbjct: 549 QENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPL 608
Query: 790 IWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNY 849
AA+ H V R+L+ +DV + LH A+ TG + A +LL+ A+
Sbjct: 609 HLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTS 668
Query: 850 HGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDL 890
G T LH+AAR + V L + A+ R TA L
Sbjct: 669 DGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHL 709
Score = 79.3 bits (194), Expect = 2e-14
Identities = 68/248 (27%), Positives = 117/248 (47%), Gaps = 6/248 (2%)
Query: 636 LVIQESERRKKLRFHPRQ-LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQ 694
L+++++ ++ F R ++++ + G+ V ++L +D + Q + PLH AA
Sbjct: 522 LLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG--KDAWLPLHYAAW 579
Query: 695 KGSVEICHVLL-QAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGST 753
+G + I +L Q G ++NA RTPL A H VAR ++ V T
Sbjct: 580 QGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQT 639
Query: 754 CLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTL 813
LH AA+ G+ LLL G A S G+T + AA + H+ +++L+ ADV
Sbjct: 640 PLHVAAETGHTSTARLLLHRG-AGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLA 698
Query: 814 TDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSR 873
LH A+ G + + E L++A + + G + LH+AA+ + V L
Sbjct: 699 RGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRH 757
Query: 874 GANPELRN 881
GA+ L++
Sbjct: 758 GAHINLQS 765
Score = 33.9 bits (76), Expect = 0.96
Identities = 33/125 (26%), Positives = 54/125 (43%), Gaps = 2/125 (1%)
Query: 762 GNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 821
G+ + +L VD+ A DSG + + A E E + LL A+ L++ +
Sbjct: 417 GDTSKLMKILQPQDVDL-ALDSGA-SLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTP 474
Query: 822 LHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 881
LH A + E+LL + ++A + T LH AA+ L L + A+ +
Sbjct: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
Query: 882 KEGDT 886
EG T
Sbjct: 535 FEGRT 539
Score = 33.9 bits (76), Expect = 0.96
Identities = 25/94 (26%), Positives = 39/94 (41%)
Query: 803 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARES 862
M + + DV L + LH A G A+ LL + + N G TPLH+A
Sbjct: 423 MKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERR 482
Query: 863 YHDCVLLFLSRGANPELRNKEGDTAWDLTPERSD 896
V L L+R + ++++ TA + D
Sbjct: 483 VRGVVELLLARKISVNAKDEDQWTALHFAAQNGD 516
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 108 bits (270), Expect = 3e-23
Identities = 77/233 (33%), Positives = 118/233 (50%), Gaps = 3/233 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+ V QG +++V L+L +D + Q+ S TPL AAQ ++C +LL GA+ N
Sbjct: 366 LHFLVAQGSVEQVRLLLAHEVDVDCQT--ASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
VD+ PL A N AR ++ G CV ++E +G T LH AA+ N E V+ LL +
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQ-NNFENVARLLVS 482
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
Q D N ++ G TP+ AA H+ ++++L ++GA++ LH A G
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
+ LL + A++ G PLH AA + + L GA+ EL +G T
Sbjct: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWT 595
Score = 98.2 bits (243), Expect = 4e-20
Identities = 70/233 (30%), Positives = 106/233 (45%), Gaps = 3/233 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+L+ + L++ DPN + +TPLH AA G V + +L GA ++A
Sbjct: 465 LHLAAQNNFENVARLLVSRQADPNLH--EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDA 522
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ RTPL AV + +++++ G + ++ G LH AA G + +LL
Sbjct: 523 QQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRY 582
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
G + GWTP+ AA H+E+I +L A++ LH A+ G A+
Sbjct: 583 G-ASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAV 641
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
LL D +A G TPLH+A + S V+ L AN RNK G T
Sbjct: 642 VSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWT 694
Score = 94.7 bits (234), Expect = 5e-19
Identities = 62/202 (30%), Positives = 101/202 (50%), Gaps = 1/202 (0%)
Query: 683 QSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGG 742
++K TPLH +GSVE +LL +++ TPL+ A + ++ ++ G
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 743 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 802
+EDG LH AA+ G+ LLL G V+AQ+ GWTP+ AA++ V R
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGAC-VDAQEREGWTPLHLAAQNNFENVAR 478
Query: 803 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARES 862
+L++R AD L + E LH A++ G ++ ++L + +L A + TPLH+A
Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERG 538
Query: 863 YHDCVLLFLSRGANPELRNKEG 884
+ L GA P+ ++ G
Sbjct: 539 KVRAIQHLLKSGAVPDALDQSG 560
Score = 92.8 bits (229), Expect = 2e-18
Identities = 73/240 (30%), Positives = 105/240 (43%), Gaps = 32/240 (13%)
Query: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 747
PLH AAQ G +LL GA ++A +++ TPL A NN VAR +V R
Sbjct: 431 PLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH 490
Query: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTG-QVDV---------------------------- 778
E +G T LH AA G++ +V LL S G ++D
Sbjct: 491 EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
Query: 779 ---NAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAE 835
+A D G+ P+ AA + +MLL GA + L ++ LH A++ G I
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
Query: 836 VLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERS 895
+L + ++ A+ TPLH+AAR V L GA+P + G T L +RS
Sbjct: 611 LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRS 670
Score = 87.8 bits (216), Expect = 6e-17
Identities = 61/191 (31%), Positives = 98/191 (51%), Gaps = 9/191 (4%)
Query: 701 CHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEE-----DGSTCL 755
C + L+ +N Q+ LM++ N+L+ A + R V EE + T L
Sbjct: 310 CKLSLRQPGEVNEDISQE---LMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPL 366
Query: 756 HHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTD 815
H G++E V LLL+ +VDV+ Q + G+TP++ AA+ + ++ +LL GAD D
Sbjct: 367 HFLVAQGSVEQVRLLLAH-EVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVD 425
Query: 816 NEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA 875
+ LH+A+ G A +LL+ + A G TPLH+AA+ ++ + L +SR A
Sbjct: 426 EDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQA 485
Query: 876 NPELRNKEGDT 886
+P L EG T
Sbjct: 486 DPNLHEAEGKT 496
Score = 87.4 bits (215), Expect = 7e-17
Identities = 61/215 (28%), Positives = 102/215 (47%), Gaps = 1/215 (0%)
Query: 667 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 726
++ LL + + Q++ RTPLH A ++G V LL++GA +A+D+ PL A
Sbjct: 509 LVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAA 568
Query: 727 VNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGW 786
+ + +++ G + G T LH AA G+LE++ LL+ ++ A + W
Sbjct: 569 ARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH-LLAESHANMGALGAVNW 627
Query: 787 TPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHA 846
TP+ AA H V+ LL GAD + LH A + LL ++HA
Sbjct: 628 TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHA 687
Query: 847 VNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 881
N G TP H+AA + + + + GA ++++
Sbjct: 688 RNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722
Score = 39.7 bits (91), Expect = 0.018
Identities = 36/118 (30%), Positives = 55/118 (46%), Gaps = 7/118 (5%)
Query: 614 NGGCLSAVG-----LPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVIL 668
N G L AV L G EA+ AL+ ++ + L+L+V++ VI
Sbjct: 618 NMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVIN 677
Query: 669 MLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 726
+L + N + + TP H AA KG+ I VL++AGA ++ D TPL A+
Sbjct: 678 LLEHHA--NVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLAL 733
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 108 bits (270), Expect = 3e-23
Identities = 74/250 (29%), Positives = 127/250 (50%), Gaps = 3/250 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ K+ ++ ++ LL + Q+ +S TP+H AA G + I +LLQ GA+ +
Sbjct: 381 LHIACKKNRIK--VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ + T L A +EV R +++ G V ++ + T LH A+++G E+V LLL
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
+A + G+TP+ +A ++V +LL GA +L + LH A+ GS +
Sbjct: 499 -MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 557
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
A++LL R + +G TPLH+AA LL L +GA+P K G T + +
Sbjct: 558 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 617
Query: 894 RSDVWFALQL 903
++ + A L
Sbjct: 618 KNQMQIASTL 627
Score = 107 bits (268), Expect = 5e-23
Identities = 74/244 (30%), Positives = 124/244 (50%), Gaps = 3/244 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ + G+++ V +L + + ++ ++ +TPLH A++ G EI +LLQ A+ +A
Sbjct: 447 LHMAARAGQVEVVRCLLRNGALVDARAREE--QTPLHIASRLGKTEIVQLLLQHMAHPDA 504
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
TPL + ++VA +++ G + G T LH AAK G+L++ LLL
Sbjct: 505 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 564
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
+ ++ G TP+ AA + + +V +LL +GA T LH A+ I
Sbjct: 565 -RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 623
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
A LLN + + V G TPLH+A++E + D V L L +GAN + K G T+ L +
Sbjct: 624 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 683
Query: 894 RSDV 897
V
Sbjct: 684 EDKV 687
Score = 103 bits (257), Expect = 1e-21
Identities = 80/267 (29%), Positives = 119/267 (44%), Gaps = 38/267 (14%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+L+ K+G + V +L + S + T LH A+ G E+ VL++ GANINA
Sbjct: 47 LHLAAKEGHVGLVQELL--GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA 104
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ TPL A NH++V +Y+++ G + EDG T L A + G+ + V++LL
Sbjct: 105 QSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 164
Query: 774 ------------------------------------GQVDVNAQDSGGWTPIIWAAEHKH 797
++ VN G+TP+ AA + +
Sbjct: 165 DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 224
Query: 798 IEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 857
+ V +LL RGA V T LH AS G+ + ++LL+ + A G TPLH
Sbjct: 225 VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 284
Query: 858 AARESYHDCVLLFLSRGANPELRNKEG 884
AAR + V L L RGA R K G
Sbjct: 285 AARSGHDQVVELLLERGAPLLARTKNG 311
Score = 102 bits (254), Expect = 2e-21
Identities = 73/200 (36%), Positives = 96/200 (48%), Gaps = 1/200 (0%)
Query: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 746
T LH AA G + +LL AN NA TPL A N ++V +V+ G + +
Sbjct: 346 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 405
Query: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
E G T +H AA +G+L +V LLL G + + G T + AA +EV+R LL
Sbjct: 406 ITESGLTPIHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLR 464
Query: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 866
GA V EE LH AS G I ++LL A +G TPLHI+ARE D
Sbjct: 465 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 524
Query: 867 VLLFLSRGANPELRNKEGDT 886
+ L GA L K+G T
Sbjct: 525 ASVLLEAGAAHSLATKKGFT 544
Score = 102 bits (253), Expect = 3e-21
Identities = 71/233 (30%), Positives = 118/233 (50%), Gaps = 3/233 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ + G+ + V L+L P+ + + TPLH +A++G V++ VLL+AGA +
Sbjct: 480 LHIASRLGKTEIVQLLLQHMAHPDAATT--NGYTPLHISAREGQVDVASVLLEAGAAHSL 537
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
K+ TPL A L+VA+ ++QR S ++G T LH AA N ++ LLL
Sbjct: 538 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 597
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
G +A G+TP+ AA+ +++ LL GA+ + + LH AS G +
Sbjct: 598 G-ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 656
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
+LL+ ++H G T LH+AA+E + + GA+ + K G T
Sbjct: 657 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 709
Score = 97.4 bits (241), Expect = 7e-20
Identities = 65/233 (27%), Positives = 118/233 (50%), Gaps = 3/233 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L++S ++G++ ++L + + + TPLH AA+ GS+++ +LLQ A ++
Sbjct: 513 LHISAREGQVDVASVLLEAGAAHSLATKKGF--TPLHVAAKYGSLDVAKLLLQRRAAADS 570
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
K TPL A ++ +VA ++++G ++ ++G T LH AAK +++ S LL+
Sbjct: 571 AGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 630
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
G + N G TP+ A++ H +++ +LL +GA++ ++ LH A+ +
Sbjct: 631 G-AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 689
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
A++L D A G TPL +A V L +GAN + K G T
Sbjct: 690 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 742
Score = 96.3 bits (238), Expect = 2e-19
Identities = 64/200 (32%), Positives = 100/200 (50%), Gaps = 2/200 (1%)
Query: 664 QKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLM 723
QKV L+LL+ + + ++ TPLH AA+K ++I LL GA N V KQ TPL
Sbjct: 588 QKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 646
Query: 724 EAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDS 783
A H ++ ++ +G ++ + G T LH AA+ + + +L G D +A
Sbjct: 647 LASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG-ADQDAHTK 705
Query: 784 GGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCD 843
G+TP+I A + +++++ LL +GA+V LH A+ G I VLL
Sbjct: 706 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 765
Query: 844 LHAVNYHGDTPLHIAARESY 863
+A +G+T L IA R Y
Sbjct: 766 PNATTANGNTALAIAKRLGY 785
Score = 93.6 bits (231), Expect = 1e-18
Identities = 72/253 (28%), Positives = 115/253 (45%), Gaps = 3/253 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ G + L+L +PN ++ + TPLH A +K +++ +L++ GA+I A
Sbjct: 348 LHVAAHCGHYRVTKLLLDKRANPNARA--LNGFTPLHIACKKNRIKVMELLVKYGASIQA 405
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ + TP+ A HL + ++Q G G T LH AA+ G +E+V LL
Sbjct: 406 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
G + V+A+ TP+ A+ E++++LL A LH ++ G +
Sbjct: 466 GAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 524
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
A VLL A G TPLH+AA+ D L L R A + K G T +
Sbjct: 525 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 584
Query: 894 RSDVWFALQLNRK 906
+ AL L K
Sbjct: 585 YDNQKVALLLLEK 597
Score = 90.1 bits (222), Expect = 1e-17
Identities = 66/244 (27%), Positives = 118/244 (48%), Gaps = 3/244 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ G + L+L +F + ++ TPLH A+++G+ + +LL G I+A
Sbjct: 216 LHIAAHYGNVNVATLLLNRGAAVDFTA--RNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ TPL A + H +V +++RG + ++ ++G + LH AA+ ++E V LL
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ- 332
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
+ V+ T + AA H V ++LL + A+ LH A +
Sbjct: 333 HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 392
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
E+L+ + A+ G TP+H+AA + + VLL L GA+P++ N G+TA +
Sbjct: 393 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 452
Query: 894 RSDV 897
V
Sbjct: 453 AGQV 456
Score = 79.7 bits (195), Expect = 2e-14
Identities = 45/140 (32%), Positives = 76/140 (54%), Gaps = 1/140 (0%)
Query: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
++ D + AA+ GNL+ V L G +D+N + G + AA+ H+ +++ LL
Sbjct: 6 QKSDSNASFLRAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLG 64
Query: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 866
RG+ V + N LH AS G A + +VL+ +++A + +G TPL++AA+E++ D
Sbjct: 65 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 124
Query: 867 VLLFLSRGANPELRNKEGDT 886
V L GAN ++G T
Sbjct: 125 VKYLLENGANQSTATEDGFT 144
Score = 79.0 bits (193), Expect = 3e-14
Identities = 65/249 (26%), Positives = 117/249 (46%), Gaps = 17/249 (6%)
Query: 657 SVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDK 716
+ + G L KV+ L +D N + Q+ LH AA++G V + LL G+++++ K
Sbjct: 17 AARAGNLDKVVEYLKGGIDIN--TCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 74
Query: 717 QQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV 776
+ T L A + EV + +V+ G + ++ ++G T L+ AA+ ++++V LL G
Sbjct: 75 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134
Query: 777 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAE 835
A + G +TP+ A + H + + +LL T + + LH A+ A
Sbjct: 135 QSTATEDG-FTPLAVALQQGHNQAVAILLEND-----TKGKVRLPALHIAARKDDTKSAA 188
Query: 836 VLLN--------ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
+LL ++ ++ G TPLHIAA + L L+RGA + + G T
Sbjct: 189 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 248
Query: 888 WDLTPERSD 896
+ +R +
Sbjct: 249 LHVASKRGN 257
Score = 68.9 bits (167), Expect = 3e-11
Identities = 48/161 (29%), Positives = 85/161 (52%), Gaps = 3/161 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+L+ ++G V L+L + N +S T LH AAQ+ V + +L + GA+ +A
Sbjct: 645 LHLASQEGHTDMVTLLL--DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
K TPL+ A ++++ +++++G V +K ++G T LH AA+ G+ ++++LL
Sbjct: 703 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 762
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLT 814
G NA + G T + A +I V+ L +VT T
Sbjct: 763 G-AKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTT 802
Score = 34.7 bits (78), Expect = 0.56
Identities = 21/75 (28%), Positives = 36/75 (48%)
Query: 813 LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 872
L ++ N A+ G+ L D++ N +G LH+AA+E + V L
Sbjct: 5 LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64
Query: 873 RGANPELRNKEGDTA 887
RG++ + K+G+TA
Sbjct: 65 RGSSVDSATKKGNTA 79
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 108 bits (270), Expect = 3e-23
Identities = 74/250 (29%), Positives = 127/250 (50%), Gaps = 3/250 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ K+ ++ ++ LL + Q+ +S TP+H AA G + I +LLQ GA+ +
Sbjct: 402 LHIACKKNRIK--VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ + T L A +EV R +++ G V ++ + T LH A+++G E+V LLL
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
+A + G+TP+ +A ++V +LL GA +L + LH A+ GS +
Sbjct: 520 -MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
A++LL R + +G TPLH+AA LL L +GA+P K G T + +
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638
Query: 894 RSDVWFALQL 903
++ + A L
Sbjct: 639 KNQMQIASTL 648
Score = 107 bits (268), Expect = 5e-23
Identities = 74/244 (30%), Positives = 124/244 (50%), Gaps = 3/244 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ + G+++ V +L + + ++ ++ +TPLH A++ G EI +LLQ A+ +A
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREE--QTPLHIASRLGKTEIVQLLLQHMAHPDA 525
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
TPL + ++VA +++ G + G T LH AAK G+L++ LLL
Sbjct: 526 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
+ ++ G TP+ AA + + +V +LL +GA T LH A+ I
Sbjct: 586 -RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 644
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
A LLN + + V G TPLH+A++E + D V L L +GAN + K G T+ L +
Sbjct: 645 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 704
Query: 894 RSDV 897
V
Sbjct: 705 EDKV 708
Score = 103 bits (257), Expect = 1e-21
Identities = 80/267 (29%), Positives = 119/267 (44%), Gaps = 38/267 (14%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+L+ K+G + V +L + S + T LH A+ G E+ VL++ GANINA
Sbjct: 68 LHLAAKEGHVGLVQELL--GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA 125
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ TPL A NH++V +Y+++ G + EDG T L A + G+ + V++LL
Sbjct: 126 QSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185
Query: 774 ------------------------------------GQVDVNAQDSGGWTPIIWAAEHKH 797
++ VN G+TP+ AA + +
Sbjct: 186 DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 245
Query: 798 IEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 857
+ V +LL RGA V T LH AS G+ + ++LL+ + A G TPLH
Sbjct: 246 VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 305
Query: 858 AARESYHDCVLLFLSRGANPELRNKEG 884
AAR + V L L RGA R K G
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNG 332
Score = 102 bits (254), Expect = 2e-21
Identities = 73/200 (36%), Positives = 96/200 (48%), Gaps = 1/200 (0%)
Query: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 746
T LH AA G + +LL AN NA TPL A N ++V +V+ G + +
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426
Query: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
E G T +H AA +G+L +V LLL G + + G T + AA +EV+R LL
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLR 485
Query: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 866
GA V EE LH AS G I ++LL A +G TPLHI+ARE D
Sbjct: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545
Query: 867 VLLFLSRGANPELRNKEGDT 886
+ L GA L K+G T
Sbjct: 546 ASVLLEAGAAHSLATKKGFT 565
Score = 102 bits (253), Expect = 3e-21
Identities = 71/233 (30%), Positives = 118/233 (50%), Gaps = 3/233 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ + G+ + V L+L P+ + + TPLH +A++G V++ VLL+AGA +
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATT--NGYTPLHISAREGQVDVASVLLEAGAAHSL 558
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
K+ TPL A L+VA+ ++QR S ++G T LH AA N ++ LLL
Sbjct: 559 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 618
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
G +A G+TP+ AA+ +++ LL GA+ + + LH AS G +
Sbjct: 619 G-ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 677
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
+LL+ ++H G T LH+AA+E + + GA+ + K G T
Sbjct: 678 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730
Score = 97.4 bits (241), Expect = 7e-20
Identities = 65/233 (27%), Positives = 118/233 (50%), Gaps = 3/233 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L++S ++G++ ++L + + + TPLH AA+ GS+++ +LLQ A ++
Sbjct: 534 LHISAREGQVDVASVLLEAGAAHSLATKKGF--TPLHVAAKYGSLDVAKLLLQRRAAADS 591
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
K TPL A ++ +VA ++++G ++ ++G T LH AAK +++ S LL+
Sbjct: 592 AGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 651
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
G + N G TP+ A++ H +++ +LL +GA++ ++ LH A+ +
Sbjct: 652 G-AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
A++L D A G TPL +A V L +GAN + K G T
Sbjct: 711 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 763
Score = 96.3 bits (238), Expect = 2e-19
Identities = 64/200 (32%), Positives = 100/200 (50%), Gaps = 2/200 (1%)
Query: 664 QKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLM 723
QKV L+LL+ + + ++ TPLH AA+K ++I LL GA N V KQ TPL
Sbjct: 609 QKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 667
Query: 724 EAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDS 783
A H ++ ++ +G ++ + G T LH AA+ + + +L G D +A
Sbjct: 668 LASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG-ADQDAHTK 726
Query: 784 GGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCD 843
G+TP+I A + +++++ LL +GA+V LH A+ G I VLL
Sbjct: 727 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
Query: 844 LHAVNYHGDTPLHIAARESY 863
+A +G+T L IA R Y
Sbjct: 787 PNATTANGNTALAIAKRLGY 806
Score = 93.6 bits (231), Expect = 1e-18
Identities = 72/253 (28%), Positives = 115/253 (45%), Gaps = 3/253 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ G + L+L +PN ++ + TPLH A +K +++ +L++ GA+I A
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARA--LNGFTPLHIACKKNRIKVMELLVKYGASIQA 426
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ + TP+ A HL + ++Q G G T LH AA+ G +E+V LL
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
G + V+A+ TP+ A+ E++++LL A LH ++ G +
Sbjct: 487 GAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
A VLL A G TPLH+AA+ D L L R A + K G T +
Sbjct: 546 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 605
Query: 894 RSDVWFALQLNRK 906
+ AL L K
Sbjct: 606 YDNQKVALLLLEK 618
Score = 90.1 bits (222), Expect = 1e-17
Identities = 66/244 (27%), Positives = 118/244 (48%), Gaps = 3/244 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ G + L+L +F + ++ TPLH A+++G+ + +LL G I+A
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTA--RNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ TPL A + H +V +++RG + ++ ++G + LH AA+ ++E V LL
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ- 353
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
+ V+ T + AA H V ++LL + A+ LH A +
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 413
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
E+L+ + A+ G TP+H+AA + + VLL L GA+P++ N G+TA +
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473
Query: 894 RSDV 897
V
Sbjct: 474 AGQV 477
Score = 81.3 bits (199), Expect = 5e-15
Identities = 46/140 (32%), Positives = 76/140 (54%), Gaps = 1/140 (0%)
Query: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
K+ D + AA+ GNL+ V L G +D+N + G + AA+ H+ +++ LL
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLG 85
Query: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 866
RG+ V + N LH AS G A + +VL+ +++A + +G TPL++AA+E++ D
Sbjct: 86 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 145
Query: 867 VLLFLSRGANPELRNKEGDT 886
V L GAN ++G T
Sbjct: 146 VKYLLENGANQSTATEDGFT 165
Score = 79.0 bits (193), Expect = 3e-14
Identities = 65/249 (26%), Positives = 117/249 (46%), Gaps = 17/249 (6%)
Query: 657 SVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDK 716
+ + G L KV+ L +D N + Q+ LH AA++G V + LL G+++++ K
Sbjct: 38 AARAGNLDKVVEYLKGGIDIN--TCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 717 QQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV 776
+ T L A + EV + +V+ G + ++ ++G T L+ AA+ ++++V LL G
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 777 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAE 835
A + G +TP+ A + H + + +LL T + + LH A+ A
Sbjct: 156 QSTATEDG-FTPLAVALQQGHNQAVAILLEND-----TKGKVRLPALHIAARKDDTKSAA 209
Query: 836 VLLN--------ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
+LL ++ ++ G TPLHIAA + L L+RGA + + G T
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269
Query: 888 WDLTPERSD 896
+ +R +
Sbjct: 270 LHVASKRGN 278
Score = 68.9 bits (167), Expect = 3e-11
Identities = 48/161 (29%), Positives = 85/161 (52%), Gaps = 3/161 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+L+ ++G V L+L + N +S T LH AAQ+ V + +L + GA+ +A
Sbjct: 666 LHLASQEGHTDMVTLLL--DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
K TPL+ A ++++ +++++G V +K ++G T LH AA+ G+ ++++LL
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLT 814
G NA + G T + A +I V+ L +VT T
Sbjct: 784 G-AKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTT 823
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 108 bits (270), Expect = 3e-23
Identities = 74/250 (29%), Positives = 127/250 (50%), Gaps = 3/250 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ K+ ++ ++ LL + Q+ +S TP+H AA G + I +LLQ GA+ +
Sbjct: 402 LHIACKKNRIK--VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ + T L A +EV R +++ G V ++ + T LH A+++G E+V LLL
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
+A + G+TP+ +A ++V +LL GA +L + LH A+ GS +
Sbjct: 520 -MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
A++LL R + +G TPLH+AA LL L +GA+P K G T + +
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638
Query: 894 RSDVWFALQL 903
++ + A L
Sbjct: 639 KNQMQIASTL 648
Score = 107 bits (268), Expect = 5e-23
Identities = 74/244 (30%), Positives = 124/244 (50%), Gaps = 3/244 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ + G+++ V +L + + ++ ++ +TPLH A++ G EI +LLQ A+ +A
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREE--QTPLHIASRLGKTEIVQLLLQHMAHPDA 525
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
TPL + ++VA +++ G + G T LH AAK G+L++ LLL
Sbjct: 526 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
+ ++ G TP+ AA + + +V +LL +GA T LH A+ I
Sbjct: 586 -RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 644
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
A LLN + + V G TPLH+A++E + D V L L +GAN + K G T+ L +
Sbjct: 645 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 704
Query: 894 RSDV 897
V
Sbjct: 705 EDKV 708
Score = 103 bits (257), Expect = 1e-21
Identities = 80/267 (29%), Positives = 119/267 (44%), Gaps = 38/267 (14%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+L+ K+G + V +L + S + T LH A+ G E+ VL++ GANINA
Sbjct: 68 LHLAAKEGHVGLVQELL--GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA 125
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ TPL A NH++V +Y+++ G + EDG T L A + G+ + V++LL
Sbjct: 126 QSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185
Query: 774 ------------------------------------GQVDVNAQDSGGWTPIIWAAEHKH 797
++ VN G+TP+ AA + +
Sbjct: 186 DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 245
Query: 798 IEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 857
+ V +LL RGA V T LH AS G+ + ++LL+ + A G TPLH
Sbjct: 246 VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 305
Query: 858 AARESYHDCVLLFLSRGANPELRNKEG 884
AAR + V L L RGA R K G
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNG 332
Score = 102 bits (254), Expect = 2e-21
Identities = 73/200 (36%), Positives = 96/200 (48%), Gaps = 1/200 (0%)
Query: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 746
T LH AA G + +LL AN NA TPL A N ++V +V+ G + +
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426
Query: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
E G T +H AA +G+L +V LLL G + + G T + AA +EV+R LL
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLR 485
Query: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 866
GA V EE LH AS G I ++LL A +G TPLHI+ARE D
Sbjct: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545
Query: 867 VLLFLSRGANPELRNKEGDT 886
+ L GA L K+G T
Sbjct: 546 ASVLLEAGAAHSLATKKGFT 565
Score = 102 bits (253), Expect = 3e-21
Identities = 71/233 (30%), Positives = 118/233 (50%), Gaps = 3/233 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ + G+ + V L+L P+ + + TPLH +A++G V++ VLL+AGA +
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATT--NGYTPLHISAREGQVDVASVLLEAGAAHSL 558
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
K+ TPL A L+VA+ ++QR S ++G T LH AA N ++ LLL
Sbjct: 559 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 618
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
G +A G+TP+ AA+ +++ LL GA+ + + LH AS G +
Sbjct: 619 G-ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 677
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
+LL+ ++H G T LH+AA+E + + GA+ + K G T
Sbjct: 678 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730
Score = 97.4 bits (241), Expect = 7e-20
Identities = 65/233 (27%), Positives = 118/233 (50%), Gaps = 3/233 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L++S ++G++ ++L + + + TPLH AA+ GS+++ +LLQ A ++
Sbjct: 534 LHISAREGQVDVASVLLEAGAAHSLATKKGF--TPLHVAAKYGSLDVAKLLLQRRAAADS 591
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
K TPL A ++ +VA ++++G ++ ++G T LH AAK +++ S LL+
Sbjct: 592 AGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 651
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
G + N G TP+ A++ H +++ +LL +GA++ ++ LH A+ +
Sbjct: 652 G-AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
A++L D A G TPL +A V L +GAN + K G T
Sbjct: 711 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 763
Score = 96.3 bits (238), Expect = 2e-19
Identities = 64/200 (32%), Positives = 100/200 (50%), Gaps = 2/200 (1%)
Query: 664 QKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLM 723
QKV L+LL+ + + ++ TPLH AA+K ++I LL GA N V KQ TPL
Sbjct: 609 QKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 667
Query: 724 EAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDS 783
A H ++ ++ +G ++ + G T LH AA+ + + +L G D +A
Sbjct: 668 LASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG-ADQDAHTK 726
Query: 784 GGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCD 843
G+TP+I A + +++++ LL +GA+V LH A+ G I VLL
Sbjct: 727 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
Query: 844 LHAVNYHGDTPLHIAARESY 863
+A +G+T L IA R Y
Sbjct: 787 PNATTANGNTALAIAKRLGY 806
Score = 93.6 bits (231), Expect = 1e-18
Identities = 72/253 (28%), Positives = 115/253 (45%), Gaps = 3/253 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ G + L+L +PN ++ + TPLH A +K +++ +L++ GA+I A
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARA--LNGFTPLHIACKKNRIKVMELLVKYGASIQA 426
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ + TP+ A HL + ++Q G G T LH AA+ G +E+V LL
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
G + V+A+ TP+ A+ E++++LL A LH ++ G +
Sbjct: 487 GAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
A VLL A G TPLH+AA+ D L L R A + K G T +
Sbjct: 546 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 605
Query: 894 RSDVWFALQLNRK 906
+ AL L K
Sbjct: 606 YDNQKVALLLLEK 618
Score = 90.1 bits (222), Expect = 1e-17
Identities = 66/244 (27%), Positives = 118/244 (48%), Gaps = 3/244 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+++ G + L+L +F + ++ TPLH A+++G+ + +LL G I+A
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTA--RNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
+ TPL A + H +V +++RG + ++ ++G + LH AA+ ++E V LL
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ- 353
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAI 833
+ V+ T + AA H V ++LL + A+ LH A +
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 413
Query: 834 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
E+L+ + A+ G TP+H+AA + + VLL L GA+P++ N G+TA +
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473
Query: 894 RSDV 897
V
Sbjct: 474 AGQV 477
Score = 81.3 bits (199), Expect = 5e-15
Identities = 46/140 (32%), Positives = 76/140 (54%), Gaps = 1/140 (0%)
Query: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
K+ D + AA+ GNL+ V L G +D+N + G + AA+ H+ +++ LL
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLG 85
Query: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 866
RG+ V + N LH AS G A + +VL+ +++A + +G TPL++AA+E++ D
Sbjct: 86 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 145
Query: 867 VLLFLSRGANPELRNKEGDT 886
V L GAN ++G T
Sbjct: 146 VKYLLENGANQSTATEDGFT 165
Score = 79.0 bits (193), Expect = 3e-14
Identities = 65/249 (26%), Positives = 117/249 (46%), Gaps = 17/249 (6%)
Query: 657 SVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDK 716
+ + G L KV+ L +D N + Q+ LH AA++G V + LL G+++++ K
Sbjct: 38 AARAGNLDKVVEYLKGGIDIN--TCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 717 QQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV 776
+ T L A + EV + +V+ G + ++ ++G T L+ AA+ ++++V LL G
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 777 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAE 835
A + G +TP+ A + H + + +LL T + + LH A+ A
Sbjct: 156 QSTATEDG-FTPLAVALQQGHNQAVAILLEND-----TKGKVRLPALHIAARKDDTKSAA 209
Query: 836 VLLN--------ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
+LL ++ ++ G TPLHIAA + L L+RGA + + G T
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269
Query: 888 WDLTPERSD 896
+ +R +
Sbjct: 270 LHVASKRGN 278
Score = 68.9 bits (167), Expect = 3e-11
Identities = 48/161 (29%), Positives = 85/161 (52%), Gaps = 3/161 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+L+ ++G V L+L + N +S T LH AAQ+ V + +L + GA+ +A
Sbjct: 666 LHLASQEGHTDMVTLLL--DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Query: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
K TPL+ A ++++ +++++G V +K ++G T LH AA+ G+ ++++LL
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Query: 774 GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLT 814
G NA + G T + A +I V+ L +VT T
Sbjct: 784 G-AKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTT 823
Score = 33.1 bits (74), Expect = 1.6
Identities = 79/414 (19%), Positives = 141/414 (34%), Gaps = 39/414 (9%)
Query: 38 HGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLE 97
H + + ++E P ++ E P SP++ T +PV +T +
Sbjct: 1854 HSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTER------HSPVSSTKTERHPPVSPS 1907
Query: 98 GDGDLRGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGA 157
G D R G K P SP G R +S +G V + +P +
Sbjct: 1908 GKTDKRPPVSPSGRTEKHPPVSP---GRTEKRLPVSPSGRTDKHQPVSTAGKTEKHLPVS 1964
Query: 158 QGAAAAGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSL 217
P T+ E + R+ M +GQ P K
Sbjct: 1965 PSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQEK 2024
Query: 218 GKVTSDLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSY 277
GKV + K L E + +R + +T G+ E V S
Sbjct: 2025 GKVRVEKEKGPILTQREAQKTENQTIKRGQRLPVT----GTAESKRGV-------RVSSI 2073
Query: 278 SVDERVDSDSKSEVEALTEQLSEEEE---EEEEEEEEEEEEEEEEEEEEDEESGNQSDRS 334
V + + K +V L+ ++ E + EEE E E +E+ +E+ D + DR
Sbjct: 2074 GVKKEDAAGGKEKV--LSHKIPEPVQSVPEEESHRESEVPKEKMADEQGDMDLQISPDRK 2131
Query: 335 GSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNG-VGSSGPSEYME---VPLG 390
S+ + K+ +D+ + R + E + + + ++ P +YM+ +P
Sbjct: 2132 TSTDFSEVIKQELEDNDKYQQFRLSEETEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPAL 2191
Query: 391 SLE----------LPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPK 434
SL+ L +EG + T + +E ++ L +P+
Sbjct: 2192 SLQSGALDGSSESLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPETSPE 2245
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 107 bits (267), Expect = 7e-23
Identities = 80/259 (30%), Positives = 122/259 (47%), Gaps = 34/259 (13%)
Query: 649 FHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 708
F L L+ +G L+ V +L D ++D+ T L A G VE+ +LL +G
Sbjct: 400 FKESALTLACYKGHLEMVRFLLEAGADQEHKTDEM--HTALMEACMDGHVEVARLLLDSG 457
Query: 709 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVS 768
A +N +PL A H+E+A +++RG + ++G T L AA+ G+ EMV+
Sbjct: 458 AQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA 517
Query: 769 LLLSTGQVDVNAQDS------------GGW-------------------TPIIWAAEHKH 797
LLL G ++NAQ GG+ TP++ AA+ H
Sbjct: 518 LLLGQG-ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGH 576
Query: 798 IEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 857
+E+++ LL GA+V T + L +A G +A+VLL A DL + G TPL
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636
Query: 858 AARESYHDCVLLFLSRGAN 876
AAR + V +S+GAN
Sbjct: 637 AARAGHVCTVQFLISKGAN 655
Score = 95.1 bits (235), Expect = 4e-19
Identities = 70/224 (31%), Positives = 111/224 (49%), Gaps = 5/224 (2%)
Query: 665 KVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLME 724
+V +LL+N + K + L A KG +E+ LL+AGA+ + T LME
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
Query: 725 AVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 784
A ++ H+EVAR ++ G V + + L AA G++E+ +LL+ G D G
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEG 500
Query: 785 GWTPIIWAAEHKHIEVIRMLLTRGADVTL-TDNEENICLHWASFTGSAAIAEVLLNARCD 843
+TP++ AA H E++ +LL +GA++ T+ + L A G +A+ L+ A D
Sbjct: 501 -YTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGAD 559
Query: 844 LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
+ TPL AA+E + + V L+ GAN GDTA
Sbjct: 560 ---IELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
Score = 89.7 bits (221), Expect = 1e-17
Identities = 101/339 (29%), Positives = 152/339 (44%), Gaps = 30/339 (8%)
Query: 555 TPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPN 614
TP AA P P + PSA + P P D A T + +LTL
Sbjct: 1040 TPTHSIAASISQP---QTPTPSPIISPSAML-----PIYPAIDIDAQTESNHDTALTLAC 1091
Query: 615 GGCLSAVGLPLGPGREALEKALVIQES--ERRKKLRFHPRQLYLSVKQGELQKVILMLLD 672
G G E L + L+ + + E R K F P L L+ G + V ++L +
Sbjct: 1092 AG-----------GHEELVQTLLERGASIEHRDKKGFTP--LILAATAGHVGVVEILLDN 1138
Query: 673 NLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLE 732
D QS++ +K TPL A G E+ +LL GAN + TPL A ++
Sbjct: 1139 GADIEAQSER-TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVN 1197
Query: 733 VARYMVQRGGCVYSK--EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQ-DSGGWTPI 789
+ + ++ G + S+ + G + L AA G+ V LLL G D+NAQ ++ T +
Sbjct: 1198 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS-DINAQIETNRNTAL 1256
Query: 790 IWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHA--V 847
A EV+ +LL R A+V L A+ G A + VLL+ D++A V
Sbjct: 1257 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1316
Query: 848 NYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
DT L IAA + ++ L + RGA+ ++RNK+G+T
Sbjct: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNT 1355
Score = 88.6 bits (218), Expect = 3e-17
Identities = 80/257 (31%), Positives = 114/257 (44%), Gaps = 40/257 (15%)
Query: 662 ELQKVILMLLDNL-DPNFQSDQQSKRTPLHAAAQKGS----------------------- 697
EL +V+L + N+ D + D TPL AAA G
Sbjct: 281 ELAQVLLAMHANVEDRGIKGDI----TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNT 336
Query: 698 ----------VEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRG-GCVYS 746
V++ VLL++GA+I ++ TPLMEA H+EVAR +++ G G
Sbjct: 337 ALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH 396
Query: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
E + L A G+LEMV LL G D + T ++ A H+EV R+LL
Sbjct: 397 SNEFKESALTLACYKGHLEMVRFLLEAG-ADQEHKTDEMHTALMEACMDGHVEVARLLLD 455
Query: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 866
GA V + + L A+ G +A +L+ L VN G TPL AARE + +
Sbjct: 456 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM 515
Query: 867 VLLFLSRGANPELRNKE 883
V L L +GAN + +E
Sbjct: 516 VALLLGQGANINAQTEE 532
Score = 87.8 bits (216), Expect = 6e-17
Identities = 73/221 (33%), Positives = 109/221 (49%), Gaps = 7/221 (3%)
Query: 661 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAV--DKQQ 718
G Q+V+ +LL N + S TPL AA G V I +LL AGA IN+ K
Sbjct: 1160 GGRQEVVELLLAR-GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1218
Query: 719 RTPLMEAVVNNHLEVARYMVQRGGCVYSK-EEDGSTCLHHAAKIGNLEMVSLLLSTGQVD 777
+PLM A +N H + ++ G + ++ E + +T L A G E+VSLLL + +
Sbjct: 1219 ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDR-KAN 1277
Query: 778 VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTL--TDNEENICLHWASFTGSAAIAE 835
V + G TP++ AA + EV R+LL +GADV + + L A+ G E
Sbjct: 1278 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1337
Query: 836 VLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGAN 876
+L+ + N G+TPL +AA + D V L + GA+
Sbjct: 1338 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1378
Score = 74.3 bits (181), Expect = 6e-13
Identities = 66/227 (29%), Positives = 102/227 (44%), Gaps = 14/227 (6%)
Query: 614 NGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDN 673
+GG ++ + + L G E S KL P L L+ G V L+L
Sbjct: 1192 SGGYVNIIKILLNAGAEI--------NSRTGSKLGISP--LMLAAMNGHTAAVKLLLDMG 1241
Query: 674 LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEV 733
D N Q + ++ T L A +G E+ +LL AN+ K TPLMEA + EV
Sbjct: 1242 SDINAQIET-NRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1300
Query: 734 ARYMVQRGGCVYSKEEDGS--TCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 791
R ++ +G V + S T L AA G+ + LL+ G ++ ++ G TP+
Sbjct: 1301 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRG-AHIDVRNKKGNTPLWL 1359
Query: 792 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLL 838
AA H++V+++L+ GADV DN + L A G + L+
Sbjct: 1360 AANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
Score = 72.0 bits (175), Expect = 3e-12
Identities = 50/153 (32%), Positives = 75/153 (49%)
Query: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 746
TPL AAQ+G +E+ LL AGAN++A T L A N H +VA ++Q G +
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
+ E G T L AA+ G++ V L+S G + T + A H+ V+ +LL
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLN 839
GAD T + + L A+ G ++ LL+
Sbjct: 686 HGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 55.5 bits (132), Expect = 3e-07
Identities = 29/81 (35%), Positives = 49/81 (60%), Gaps = 4/81 (4%)
Query: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 746
TPL AA G +++ +L+QAGA+++A D ++ TPLM A H++V RY+V+ +
Sbjct: 1355 TPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE----VN 1410
Query: 747 KEEDGSTCLHHAAKIGNLEMV 767
+ S C+ + A I + EM+
Sbjct: 1411 QFPSDSECMRYIATITDKEML 1431
Score = 48.9 bits (115), Expect = 3e-05
Identities = 32/96 (33%), Positives = 45/96 (46%), Gaps = 1/96 (1%)
Query: 677 NFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN-AVDKQQRTPLMEAVVNNHLEVAR 735
+ + + + RTPL AA+ G V L+ GAN+N T L A HL V
Sbjct: 622 DLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVE 681
Query: 736 YMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 771
++ G + +DGST L AAK G+ +V LL
Sbjct: 682 LLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
Score = 34.7 bits (78), Expect = 0.56
Identities = 28/97 (28%), Positives = 40/97 (41%), Gaps = 1/97 (1%)
Query: 792 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 851
A + +R LL G V E L A G +A+VLL ++ G
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 852 D-TPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
D TPL AA + V L L+ A+ ++ G+TA
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTA 337
Score = 33.5 bits (75), Expect = 1.3
Identities = 44/199 (22%), Positives = 73/199 (36%), Gaps = 27/199 (13%)
Query: 28 KETRGATERVHGSLGDTPRSEETLPKAT-PDSLEPAGPSSPAS-----VTVTVGDEGADT 81
+ + G+ GSL +P + + +T P + PSSP+ VTV T
Sbjct: 1952 QNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTT 2011
Query: 82 PVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSPSK---------------GGSC 126
V T + N H S PSSPS G +
Sbjct: 2012 TVTTTA----SNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSAS 2067
Query: 127 PSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGS--EPPPATTSPEGQPKVHRAR 184
P++ S SPP V++ R + + G+++A S + PP + S E +P + +++
Sbjct: 2068 PNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQ 2127
Query: 185 KTMSKPGNGQPPVPEKRPP 203
+ PP+ P
Sbjct: 2128 VPPPEVRMTVPPLATSSAP 2146
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 107 bits (267), Expect = 7e-23
Identities = 80/259 (30%), Positives = 122/259 (47%), Gaps = 34/259 (13%)
Query: 649 FHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 708
F L L+ +G L+ V +L D ++D+ T L A G VE+ +LL +G
Sbjct: 400 FKESALTLACYKGHLEMVRFLLEAGADQEHKTDEM--HTALMEACMDGHVEVARLLLDSG 457
Query: 709 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVS 768
A +N +PL A H+E+A +++RG + ++G T L AA+ G+ EMV+
Sbjct: 458 AQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA 517
Query: 769 LLLSTGQVDVNAQDS------------GGW-------------------TPIIWAAEHKH 797
LLL G ++NAQ GG+ TP++ AA+ H
Sbjct: 518 LLLGQG-ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGH 576
Query: 798 IEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 857
+E+++ LL GA+V T + L +A G +A+VLL A DL + G TPL
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636
Query: 858 AARESYHDCVLLFLSRGAN 876
AAR + V +S+GAN
Sbjct: 637 AARAGHVCTVQFLISKGAN 655
Score = 95.1 bits (235), Expect = 4e-19
Identities = 70/224 (31%), Positives = 111/224 (49%), Gaps = 5/224 (2%)
Query: 665 KVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLME 724
+V +LL+N + K + L A KG +E+ LL+AGA+ + T LME
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
Query: 725 AVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 784
A ++ H+EVAR ++ G V + + L AA G++E+ +LL+ G D G
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEG 500
Query: 785 GWTPIIWAAEHKHIEVIRMLLTRGADVTL-TDNEENICLHWASFTGSAAIAEVLLNARCD 843
+TP++ AA H E++ +LL +GA++ T+ + L A G +A+ L+ A D
Sbjct: 501 -YTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGAD 559
Query: 844 LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
+ TPL AA+E + + V L+ GAN GDTA
Sbjct: 560 ---IELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
Score = 91.3 bits (225), Expect = 5e-18
Identities = 104/366 (28%), Positives = 167/366 (45%), Gaps = 32/366 (8%)
Query: 542 EAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRAD--TSQPSARMRGH-GEPRRPPCDP 598
+A + +P + PPA A P ++ V GRA ++ P+ + +P+ P P
Sbjct: 750 QALPMVVPPQEPDKPPANVATTLPIR-NKAVSGRASAMSNTPTHSIAASISQPQTPTPSP 808
Query: 599 LADTIDSSGPSLTLPNGGCL-----------SAVGLPLGPGREALEKALVIQES--ERRK 645
+ PS LP + +A+ L G E L + L+ + + E R
Sbjct: 809 IIS------PSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRD 862
Query: 646 KLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLL 705
K F P L L+ G + V ++L + D QS++ +K TPL A G E+ +LL
Sbjct: 863 KKGFTP--LILAATAGHVGVVEILLDNGADIEAQSER-TKDTPLSLACSGGRQEVVELLL 919
Query: 706 QAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK--EEDGSTCLHHAAKIGN 763
GAN + TPL A ++ + + ++ G + S+ + G + L AA G+
Sbjct: 920 ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 979
Query: 764 LEMVSLLLSTGQVDVNAQ-DSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICL 822
V LLL G D+NAQ ++ T + A EV+ +LL R A+V L
Sbjct: 980 TAAVKLLLDMGS-DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPL 1038
Query: 823 HWASFTGSAAIAEVLLNARCDLHA--VNYHGDTPLHIAARESYHDCVLLFLSRGANPELR 880
A+ G A + VLL+ D++A V DT L IAA + ++ L + RGA+ ++R
Sbjct: 1039 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR 1098
Query: 881 NKEGDT 886
NK+G+T
Sbjct: 1099 NKKGNT 1104
Score = 88.6 bits (218), Expect = 3e-17
Identities = 80/257 (31%), Positives = 114/257 (44%), Gaps = 40/257 (15%)
Query: 662 ELQKVILMLLDNL-DPNFQSDQQSKRTPLHAAAQKGS----------------------- 697
EL +V+L + N+ D + D TPL AAA G
Sbjct: 281 ELAQVLLAMHANVEDRGIKGDI----TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNT 336
Query: 698 ----------VEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRG-GCVYS 746
V++ VLL++GA+I ++ TPLMEA H+EVAR +++ G G
Sbjct: 337 ALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH 396
Query: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
E + L A G+LEMV LL G D + T ++ A H+EV R+LL
Sbjct: 397 SNEFKESALTLACYKGHLEMVRFLLEAG-ADQEHKTDEMHTALMEACMDGHVEVARLLLD 455
Query: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC 866
GA V + + L A+ G +A +L+ L VN G TPL AARE + +
Sbjct: 456 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM 515
Query: 867 VLLFLSRGANPELRNKE 883
V L L +GAN + +E
Sbjct: 516 VALLLGQGANINAQTEE 532
Score = 87.8 bits (216), Expect = 6e-17
Identities = 73/221 (33%), Positives = 109/221 (49%), Gaps = 7/221 (3%)
Query: 661 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAV--DKQQ 718
G Q+V+ +LL N + S TPL AA G V I +LL AGA IN+ K
Sbjct: 909 GGRQEVVELLLAR-GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 967
Query: 719 RTPLMEAVVNNHLEVARYMVQRGGCVYSK-EEDGSTCLHHAAKIGNLEMVSLLLSTGQVD 777
+PLM A +N H + ++ G + ++ E + +T L A G E+VSLLL + +
Sbjct: 968 ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDR-KAN 1026
Query: 778 VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTL--TDNEENICLHWASFTGSAAIAE 835
V + G TP++ AA + EV R+LL +GADV + + L A+ G E
Sbjct: 1027 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1086
Query: 836 VLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGAN 876
+L+ + N G+TPL +AA + D V L + GA+
Sbjct: 1087 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1127
Score = 74.3 bits (181), Expect = 6e-13
Identities = 66/227 (29%), Positives = 102/227 (44%), Gaps = 14/227 (6%)
Query: 614 NGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDN 673
+GG ++ + + L G E S KL P L L+ G V L+L
Sbjct: 941 SGGYVNIIKILLNAGAEI--------NSRTGSKLGISP--LMLAAMNGHTAAVKLLLDMG 990
Query: 674 LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEV 733
D N Q + ++ T L A +G E+ +LL AN+ K TPLMEA + EV
Sbjct: 991 SDINAQIET-NRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1049
Query: 734 ARYMVQRGGCVYSKEEDGS--TCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 791
R ++ +G V + S T L AA G+ + LL+ G ++ ++ G TP+
Sbjct: 1050 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRG-AHIDVRNKKGNTPLWL 1108
Query: 792 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLL 838
AA H++V+++L+ GADV DN + L A G + L+
Sbjct: 1109 AANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155
Score = 72.0 bits (175), Expect = 3e-12
Identities = 50/153 (32%), Positives = 75/153 (49%)
Query: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 746
TPL AAQ+G +E+ LL AGAN++A T L A N H +VA ++Q G +
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
+ E G T L AA+ G++ V L+S G + T + A H+ V+ +LL
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLN 839
GAD T + + L A+ G ++ LL+
Sbjct: 686 HGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 55.5 bits (132), Expect = 3e-07
Identities = 29/81 (35%), Positives = 49/81 (60%), Gaps = 4/81 (4%)
Query: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 746
TPL AA G +++ +L+QAGA+++A D ++ TPLM A H++V RY+V+ +
Sbjct: 1104 TPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE----VN 1159
Query: 747 KEEDGSTCLHHAAKIGNLEMV 767
+ S C+ + A I + EM+
Sbjct: 1160 QFPSDSECMRYIATITDKEML 1180
Score = 48.9 bits (115), Expect = 3e-05
Identities = 32/96 (33%), Positives = 45/96 (46%), Gaps = 1/96 (1%)
Query: 677 NFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN-AVDKQQRTPLMEAVVNNHLEVAR 735
+ + + + RTPL AA+ G V L+ GAN+N T L A HL V
Sbjct: 622 DLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVE 681
Query: 736 YMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 771
++ G + +DGST L AAK G+ +V LL
Sbjct: 682 LLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
Score = 34.7 bits (78), Expect = 0.56
Identities = 28/97 (28%), Positives = 40/97 (41%), Gaps = 1/97 (1%)
Query: 792 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 851
A + +R LL G V E L A G +A+VLL ++ G
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 852 D-TPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
D TPL AA + V L L+ A+ ++ G+TA
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTA 337
Score = 33.5 bits (75), Expect = 1.3
Identities = 44/199 (22%), Positives = 73/199 (36%), Gaps = 27/199 (13%)
Query: 28 KETRGATERVHGSLGDTPRSEETLPKAT-PDSLEPAGPSSPAS-----VTVTVGDEGADT 81
+ + G+ GSL +P + + +T P + PSSP+ VTV T
Sbjct: 1701 QNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTT 1760
Query: 82 PVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSPSK---------------GGSC 126
V T + N H S PSSPS G +
Sbjct: 1761 TVTTTA----SNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSAS 1816
Query: 127 PSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGS--EPPPATTSPEGQPKVHRAR 184
P++ S SPP V++ R + + G+++A S + PP + S E +P + +++
Sbjct: 1817 PNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQ 1876
Query: 185 KTMSKPGNGQPPVPEKRPP 203
+ PP+ P
Sbjct: 1877 VPPPEVRMTVPPLATSSAP 1895
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 107 bits (266), Expect = 9e-23
Identities = 73/237 (30%), Positives = 110/237 (46%), Gaps = 34/237 (14%)
Query: 683 QSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGG 742
Q +RTPLHAAA G V I +LL +GAN+NA D TPL A + + +V ++
Sbjct: 39 QERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSA 98
Query: 743 CVYSKEE---------------------------------DGSTCLHHAAKIGNLEMVSL 769
V ++++ G + LHHA G+LE V+L
Sbjct: 99 DVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNL 158
Query: 770 LLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTG 829
LL+ G +N D P+ WAA H+EV+++L+ RGAD+ D + LH A+ +G
Sbjct: 159 LLNKG-ASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASG 217
Query: 830 SAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
+ + LL ++ N G+T LHIA + ++ GAN N +G T
Sbjct: 218 QIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFT 274
Score = 95.5 bits (236), Expect = 3e-19
Identities = 65/231 (28%), Positives = 103/231 (44%), Gaps = 33/231 (14%)
Query: 683 QSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGG 742
+S R+ LH A G +E ++LL GA++N DK++R PL A HLEV + +V RG
Sbjct: 138 RSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGA 197
Query: 743 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQ--------------------------- 775
+ K+ G LH AA G +E+V LL G
Sbjct: 198 DLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIE 257
Query: 776 -----VDVNAQDSGGWTPI-IWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTG 829
+VN + G+TP+ + A + +L+ GADV E LH A+ G
Sbjct: 258 LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHG 317
Query: 830 SAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELR 880
+++L+ ++ + G+TPLH+AAR + + ++ GA+ R
Sbjct: 318 RFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARR 368
Score = 85.9 bits (211), Expect = 2e-16
Identities = 74/228 (32%), Positives = 105/228 (46%), Gaps = 8/228 (3%)
Query: 665 KVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLME 724
+ +L + DP S +P+H A+ G E C LL + + ++ TPL
Sbjct: 771 RTLLQAALSTDPLDAGVDYSGYSPMHWASYTGH-EDCLELLLEHSPFSYLEGNPFTPLHC 829
Query: 725 AVVNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQD 782
AV+NN ++ G V S++ G T LH AA N+ + +LL Q +VNA D
Sbjct: 830 AVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQH-QAEVNATD 888
Query: 783 SGGWTPIIWAAEHKHIEVIRMLLTRG-ADVTLTDNEENICLHWASFTGSAAIAEVLLNAR 841
G T ++ AAE+ + LL RG AD+T+ D +N LH A G A ++L
Sbjct: 889 HTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAET 948
Query: 842 CDLHAVNYHGDT---PLHIAARESYHDCVLLFLSRGANPELRNKEGDT 886
DL +N PLHIAAR V LS GA ++EG T
Sbjct: 949 QDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHT 996
Score = 84.7 bits (208), Expect = 5e-16
Identities = 67/233 (28%), Positives = 102/233 (43%), Gaps = 34/233 (14%)
Query: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 747
PL A VE LL NIN +D+++RTPL A + + + ++ G V +K
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHK----------- 796
+ T LH AA N +++ LLL+ DVNA+D TP+ AA ++
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLA-HSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
Query: 797 ----------------------HIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIA 834
H+E + +LL +GA + + D +E LHWA+F G +
Sbjct: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL 189
Query: 835 EVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
++L+ DL + G LH AA + V L GA + N G+TA
Sbjct: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTA 242
Score = 83.6 bits (205), Expect = 1e-15
Identities = 73/265 (27%), Positives = 112/265 (42%), Gaps = 47/265 (17%)
Query: 668 LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVV 727
L++ + D N+QS + ++PLH AA G +L+Q G+ I+ DK TPL A
Sbjct: 291 LLVNNGADVNYQSKEG--KSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAAR 348
Query: 728 NNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV----------- 776
H + ++ G + LH A G + LLS+GQ+
Sbjct: 349 YGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEH 408
Query: 777 ------DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGS 830
D+N D+ G T + AA ++E + +LL+ GAD+ D LH+A+ GS
Sbjct: 409 VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468
Query: 831 AAIAEVLLNARCDLHAVNYHGDTPLHIAARE-----------SYHD-------------- 865
A L+ A ++ + G +PLH AA S HD
Sbjct: 469 YQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKE 528
Query: 866 ---CVLLFLSRGANPELRNKEGDTA 887
C+ L GA+P LR+++G TA
Sbjct: 529 AFFCLEFLLDNGADPSLRDRQGYTA 553
Score = 82.8 bits (203), Expect = 2e-15
Identities = 60/231 (25%), Positives = 102/231 (44%), Gaps = 20/231 (8%)
Query: 664 QKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEIC-HVLLQAGANINAVDKQQRTPL 722
Q + + L N N TPLH AA + +C +L+ GA++N K+ ++PL
Sbjct: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310
Query: 723 MEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQD 782
A ++ ++ ++Q G + ++ G+T LH AA+ G+ ++S L++ G D +
Sbjct: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNG-ADTARRG 369
Query: 783 SGGWTPIIWAAEHKHIEVIRMLLTRGA------------------DVTLTDNEENICLHW 824
P+ A + R LL+ G D+ DN CLH
Sbjct: 370 IHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHA 429
Query: 825 ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA 875
A+ G+ +LL++ DL + G TPLH AA + C + ++ GA
Sbjct: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480
Score = 79.0 bits (193), Expect = 3e-14
Identities = 60/212 (28%), Positives = 100/212 (47%), Gaps = 10/212 (4%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGAN--- 710
L+L+ ++G + V ++ + +++ K TPLHAAA G + H+L+ +G
Sbjct: 622 LFLATERGSTECVEVLTAHGASALIK-ERKRKWTPLHAAAASGHTDSLHLLIDSGERADI 680
Query: 711 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 770
+ +D +TPLM A++N H++ ++++G + + G T LH A G + ++ L
Sbjct: 681 TDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAAL 740
Query: 771 LSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC----LHWAS 826
L V +D G TPI A+ H V+R LL D + +HWAS
Sbjct: 741 LD-HDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWAS 799
Query: 827 FTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 858
+TG E+LL + + TPLH A
Sbjct: 800 YTGHEDCLELLLE-HSPFSYLEGNPFTPLHCA 830
Score = 78.2 bits (191), Expect = 4e-14
Identities = 70/252 (27%), Positives = 108/252 (42%), Gaps = 22/252 (8%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+ + G+++ V +L + T LH A G + L+ AGAN+N
Sbjct: 210 LHTAAASGQIEVVKYLL--RMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQ 267
Query: 714 VDKQQRTPL-MEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 772
+ + TPL + AV N +V G V + ++G + LH AA G +L+
Sbjct: 268 PNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQ 327
Query: 773 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTG--- 829
G +++ D G TP+ AA + H +I L+T GAD + LH A G
Sbjct: 328 NGS-EIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSD 386
Query: 830 ---------------SAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRG 874
S+ E +L+A D++ + G T LH AA +C+ L LS G
Sbjct: 387 CCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSG 446
Query: 875 ANPELRNKEGDT 886
A+ R+K G T
Sbjct: 447 ADLRRRDKFGRT 458
Score = 74.3 bits (181), Expect = 6e-13
Identities = 54/192 (28%), Positives = 87/192 (45%), Gaps = 4/192 (2%)
Query: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 746
+PLH AA G E L + N++ D + RT L A E + G
Sbjct: 587 SPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALI 646
Query: 747 KEEDGS-TCLHHAAKIGNLEMVSLLLSTGQ-VDV-NAQDSGGWTPIIWAAEHKHIEVIRM 803
KE T LH AA G+ + + LL+ +G+ D+ + D+ G TP++ A + H++ + +
Sbjct: 647 KERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHL 706
Query: 804 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 863
LL +G+ D LH + TG LL+ + ++ G TP+H+A+
Sbjct: 707 LLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLAS-ACG 765
Query: 864 HDCVLLFLSRGA 875
H VL L + A
Sbjct: 766 HTAVLRTLLQAA 777
Score = 73.2 bits (178), Expect = 1e-12
Identities = 60/211 (28%), Positives = 96/211 (45%), Gaps = 8/211 (3%)
Query: 686 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 745
RT LHAAA G+VE ++LL +GA++ DK RTPL A N + A +V G V
Sbjct: 424 RTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVN 483
Query: 746 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL 805
+ G + LH+AA ++ D+ P+ + + + LL
Sbjct: 484 EADCKGCSPLHYAAASDTYRRAE------PHTPSSHDAEEDEPLKESRRKEAFFCLEFLL 537
Query: 806 TRGADVTLTDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGDTPLHIAARESY 863
GAD +L D + +H+A+ G+ E+LL + C + +PLH+AA +
Sbjct: 538 DNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGH 597
Query: 864 HDCVLLFLSRGANPELRNKEGDTAWDLTPER 894
+ + N ++R+ +G TA L ER
Sbjct: 598 CEALKTLAETLVNLDVRDHKGRTALFLATER 628
Score = 72.0 bits (175), Expect = 3e-12
Identities = 58/194 (29%), Positives = 93/194 (47%), Gaps = 9/194 (4%)
Query: 686 RTPLHAAAQKGSVEICHVLLQAGANIN----AVDKQQRTPLMEAVVNNHLEVARYMVQRG 741
RTP+H A+ G + LLQA + + VD +P+ A H + +++
Sbjct: 755 RTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHS 814
Query: 742 GCVYSKEEDGSTCLHHAAKIGNLEMVS--LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 799
Y E + T LH A I N + + LL + G VN++D+ G TP+ AA ++
Sbjct: 815 PFSYL-EGNPFTPLH-CAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVS 872
Query: 800 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLL-NARCDLHAVNYHGDTPLHIA 858
+RMLL A+V TD+ L A+ G A E LL + DL ++ + +T LH+A
Sbjct: 873 GLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLA 932
Query: 859 ARESYHDCVLLFLS 872
+ + C L+ L+
Sbjct: 933 CSKGHEKCALMILA 946
Score = 65.9 bits (159), Expect = 2e-10
Identities = 67/300 (22%), Positives = 116/300 (38%), Gaps = 68/300 (22%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
L+ + G ++ + L+L D + + RTPLH AA GS + L+ AGA +N
Sbjct: 427 LHAAASGGNVECLNLLLSSGAD--LRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE 484
Query: 714 VDKQQRTPLMEAVVNNHLEVAR----------------------------YMVQRGGCVY 745
D + +PL A ++ A +++ G
Sbjct: 485 ADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544
Query: 746 SKEEDGSTCLHHAAKIGNLEMVSLLLSTG------------------------------- 774
++ G T +H+AA GN + + LLL
Sbjct: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTL 604
Query: 775 ---QVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC-LHWASFTGS 830
V+++ +D G T + A E E + +L GA + + + LH A+ +G
Sbjct: 605 AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGH 664
Query: 831 AAIAEVLLNA--RCDLHAV-NYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTA 887
+L+++ R D+ V + +G TPL +A + DCV L L +G+ + + G TA
Sbjct: 665 TDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTA 724
Score = 63.9 bits (154), Expect = 9e-10
Identities = 64/228 (28%), Positives = 97/228 (42%), Gaps = 15/228 (6%)
Query: 654 LYLSVKQG--ELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANI 711
L+L+ G E K + L NLD RT L A ++GS E VL GA+
Sbjct: 589 LHLAAYNGHCEALKTLAETLVNLDVR----DHKGRTALFLATERGSTECVEVLTAHGASA 644
Query: 712 NAVDKQQR-TPLMEAVVNNHLEVARYMV---QRGGCVYSKEEDGSTCLHHAAKIGNLEMV 767
+++++ TPL A + H + ++ +R + G T L A G+++ V
Sbjct: 645 LIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCV 704
Query: 768 SLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASF 827
LLL G +A D G T + A + + LL A V D + +H AS
Sbjct: 705 HLLLEKGST-ADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASA 763
Query: 828 TGSAAIAEVLLNARCDLH----AVNYHGDTPLHIAARESYHDCVLLFL 871
G A+ LL A V+Y G +P+H A+ + DC+ L L
Sbjct: 764 CGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLL 811
Score = 63.5 bits (153), Expect = 1e-09
Identities = 56/208 (26%), Positives = 90/208 (43%), Gaps = 8/208 (3%)
Query: 686 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 745
+TPL A G V+ H+LL+ G+ +A D + RT L V + ++ V
Sbjct: 689 QTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVL 748
Query: 746 SKEEDGSTCLHHAAKIGNLEMVSLL----LSTGQVDVNAQDSGGWTPIIWAAEHKHIEVI 801
++ G T +H A+ G+ ++ L LST +D D G++P+ WA+ H + +
Sbjct: 749 CRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGV-DYSGYSPMHWASYTGHEDCL 807
Query: 802 RMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA--RCDLHAVNYHGDTPLHIAA 859
+LL L N LH A + E+LL A +++ + G TPLH AA
Sbjct: 808 ELLLEHSPFSYLEGNPFT-PLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAA 866
Query: 860 RESYHDCVLLFLSRGANPELRNKEGDTA 887
+ + L A + G TA
Sbjct: 867 FADNVSGLRMLLQHQAEVNATDHTGRTA 894
Score = 39.3 bits (90), Expect = 0.023
Identities = 21/76 (27%), Positives = 38/76 (50%), Gaps = 1/76 (1%)
Query: 654 LYLSVKQGELQKVILMLLDNLDPNF-QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 712
L+L+ +G + +++L + D + + + PLH AA+ G + LL GA +
Sbjct: 929 LHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVL 988
Query: 713 AVDKQQRTPLMEAVVN 728
AVD++ TP + N
Sbjct: 989 AVDEEGHTPALACAPN 1004
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,806,836
Number of Sequences: 37866
Number of extensions: 3134463
Number of successful extensions: 93622
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1539
Number of HSP's successfully gapped in prelim test: 754
Number of HSP's that attempted gapping in prelim test: 30341
Number of HSP's gapped (non-prelim): 26858
length of query: 1210
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1096
effective length of database: 13,930,794
effective search space: 15268150224
effective search space used: 15268150224
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.