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Search of human proteins with 156105707
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156105707 SNF related kinase [Homo sapiens]
(765 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156105707 SNF related kinase [Homo sapiens] 1538 0.0
gi|156105705 SNF related kinase [Homo sapiens] 1538 0.0
gi|116256471 SNF1-like kinase [Homo sapiens] 286 5e-77
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 281 1e-75
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 280 5e-75
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 273 6e-73
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 272 7e-73
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 271 2e-72
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 270 5e-72
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 269 6e-72
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 269 6e-72
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 268 1e-71
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 268 1e-71
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 268 1e-71
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 268 1e-71
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 265 2e-70
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 224 2e-58
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 221 3e-57
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 220 3e-57
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 220 4e-57
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 217 3e-56
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 216 5e-56
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 211 2e-54
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 190 4e-48
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 186 5e-47
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 185 1e-46
gi|194294513 testis-specific serine kinase 2 [Homo sapiens] 182 1e-45
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 180 4e-45
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 180 4e-45
gi|14042947 testis-specific serine kinase 1 [Homo sapiens] 174 2e-43
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 1538 bits (3983), Expect = 0.0
Identities = 765/765 (100%), Positives = 765/765 (100%)
Query: 1 MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHL 60
MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHL
Sbjct: 1 MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHL 60
Query: 61 FQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYF 120
FQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYF
Sbjct: 61 FQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYF 120
Query: 121 AQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAY 180
AQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAY
Sbjct: 121 AQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAY 180
Query: 181 SAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSK 240
SAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSK
Sbjct: 181 SAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSK 240
Query: 241 ECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQ 300
ECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQ
Sbjct: 241 ECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQ 300
Query: 301 RMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFR 360
RMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFR
Sbjct: 301 RMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFR 360
Query: 361 QSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELA 420
QSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELA
Sbjct: 361 QSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELA 420
Query: 421 GPALSTVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSR 480
GPALSTVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSR
Sbjct: 421 GPALSTVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSR 480
Query: 481 KSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSS 540
KSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSS
Sbjct: 481 KSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSS 540
Query: 541 SETSDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSE 600
SETSDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSE
Sbjct: 541 SETSDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSE 600
Query: 601 NNAGGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASRSAGELVESLKLMSLCLGSQLHG 660
NNAGGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASRSAGELVESLKLMSLCLGSQLHG
Sbjct: 601 NNAGGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASRSAGELVESLKLMSLCLGSQLHG 660
Query: 661 STKYIIDPQNGLSFSSVKVQEKSTWKMCISSTGNAGQVPAVGGIKFFSDHMADTTTELER 720
STKYIIDPQNGLSFSSVKVQEKSTWKMCISSTGNAGQVPAVGGIKFFSDHMADTTTELER
Sbjct: 661 STKYIIDPQNGLSFSSVKVQEKSTWKMCISSTGNAGQVPAVGGIKFFSDHMADTTTELER 720
Query: 721 IKSKNLKNNVLQLPLCEKTISVNIQRNPKEGLLCASSPASCCHVI 765
IKSKNLKNNVLQLPLCEKTISVNIQRNPKEGLLCASSPASCCHVI
Sbjct: 721 IKSKNLKNNVLQLPLCEKTISVNIQRNPKEGLLCASSPASCCHVI 765
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 1538 bits (3983), Expect = 0.0
Identities = 765/765 (100%), Positives = 765/765 (100%)
Query: 1 MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHL 60
MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHL
Sbjct: 1 MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHL 60
Query: 61 FQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYF 120
FQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYF
Sbjct: 61 FQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYF 120
Query: 121 AQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAY 180
AQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAY
Sbjct: 121 AQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAY 180
Query: 181 SAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSK 240
SAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSK
Sbjct: 181 SAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSK 240
Query: 241 ECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQ 300
ECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQ
Sbjct: 241 ECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQ 300
Query: 301 RMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFR 360
RMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFR
Sbjct: 301 RMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFR 360
Query: 361 QSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELA 420
QSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELA
Sbjct: 361 QSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELA 420
Query: 421 GPALSTVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSR 480
GPALSTVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSR
Sbjct: 421 GPALSTVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSR 480
Query: 481 KSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSS 540
KSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSS
Sbjct: 481 KSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSS 540
Query: 541 SETSDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSE 600
SETSDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSE
Sbjct: 541 SETSDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSE 600
Query: 601 NNAGGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASRSAGELVESLKLMSLCLGSQLHG 660
NNAGGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASRSAGELVESLKLMSLCLGSQLHG
Sbjct: 601 NNAGGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASRSAGELVESLKLMSLCLGSQLHG 660
Query: 661 STKYIIDPQNGLSFSSVKVQEKSTWKMCISSTGNAGQVPAVGGIKFFSDHMADTTTELER 720
STKYIIDPQNGLSFSSVKVQEKSTWKMCISSTGNAGQVPAVGGIKFFSDHMADTTTELER
Sbjct: 661 STKYIIDPQNGLSFSSVKVQEKSTWKMCISSTGNAGQVPAVGGIKFFSDHMADTTTELER 720
Query: 721 IKSKNLKNNVLQLPLCEKTISVNIQRNPKEGLLCASSPASCCHVI 765
IKSKNLKNNVLQLPLCEKTISVNIQRNPKEGLLCASSPASCCHVI
Sbjct: 721 IKSKNLKNNVLQLPLCEKTISVNIQRNPKEGLLCASSPASCCHVI 765
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 286 bits (732), Expect = 5e-77
Identities = 170/476 (35%), Positives = 263/476 (55%), Gaps = 24/476 (5%)
Query: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
G YD+++TLG+G+FAVVKLARH T +VA+K+IDKT+LD+ +++EV+ MKL+ HP
Sbjct: 25 GFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHP 84
Query: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
+I++LY+V++T+ LY++ E G+MFDY+ + L+E+ A+K F QI+ A+ YCH
Sbjct: 85 HIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGH-LSENEARKKFWQILSAVEYCHDH 143
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
H+VHRDLK EN++ +KL DFGF N ++ G+ L+T CGS Y+APE+ G EY+
Sbjct: 144 HIVHRDLKTENLLLDGNMD-IKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEG 202
Query: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
P +DIWSLGV+L++LVCG PF N +++ ++ +P +S++C+ LI RML D
Sbjct: 203 PQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVD 262
Query: 254 PKRRASLEEIENHPWLQGVD--PSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRD 311
P RR ++ +I H W++ P PA NL + + ++ LG DR
Sbjct: 263 PARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLG--VDRQ 320
Query: 312 AIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQ 371
VE+L+ + YNH A Y+LL ER+ K+ + Q P+ + + R S + ++VPQ
Sbjct: 321 RTVESLQNSSYNHFAAIYYLLLERL---KEYRNAQCARPGPAR-QPRPRSSDLSGLEVPQ 376
Query: 372 DLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALS------ 425
+ L+ P A + P SVL C+ P S
Sbjct: 377 ---EGLSTDPFRPALLCPQPQTLVQSVLQAEMD---CELQSSLQWPLFFPVDASCSGVFR 430
Query: 426 --TVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTS 479
V P+SL TA + +EE+D ++ P S + L + + LT+
Sbjct: 431 PRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTA 486
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 281 bits (720), Expect = 1e-75
Identities = 202/608 (33%), Positives = 300/608 (49%), Gaps = 73/608 (12%)
Query: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
G Y L KT+G+G+FA VKLARH+ TG++VAVK+IDKT+L++ + LF+EVR MK++ HP
Sbjct: 51 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
Query: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
NIV+L+EVI+T+ LYL++E GG++FDY++ H + E A+ F QIV A+ YCH+
Sbjct: 111 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCHQK 169
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
+VHRDLK EN++ + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD
Sbjct: 170 FIVHRDLKAENLL-LDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
P VD+WSLGVIL+ LV G PF N E ++ KY +P ++S +C++L+ + L +
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
Query: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312
P +R +LE+I W+ G + Y PL YK+ E +++ R+
Sbjct: 289 PSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREE 341
Query: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372
I ++L RYN + ATY LL + E E T + P
Sbjct: 342 IQDSLVGQRYNEVMATYLLLGYK----SSELEGDTITLKPR------------------- 378
Query: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432
+ L++++ P + SV + + D A AGPA+ T S
Sbjct: 379 -----PSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQA--------AGPAIPTSNSYSK 425
Query: 433 KPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEE 492
K ++ + + EED E + S + +V P + + T+ P N +
Sbjct: 426 KTQSNNAE-----NKRPEEDRESGRKASSTAKVPASPLPGLERKKTT--PTPSTNSVLST 478
Query: 493 GESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRR 552
+ P L R AS G + + GS S++ S S +R
Sbjct: 479 STNRSRNS------PLLER-----ASLGQASIQNGKDSLTMPGSRASTASASAAVSAARP 527
Query: 553 RLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSENNAGGGSPSSGS 612
R + S + S H +S PP +PS A V ASPS +N S S
Sbjct: 528 RQHQKS-MSASVHPNKASGLPPTE--SNCEVPRPSTAPQRVPVASPSAHNI------SSS 578
Query: 613 GGNPTNTS 620
GG P T+
Sbjct: 579 GGAPDRTN 586
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 280 bits (715), Expect = 5e-75
Identities = 201/608 (33%), Positives = 299/608 (49%), Gaps = 74/608 (12%)
Query: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
G Y L KT+G+G+FA VKLARH+ TG++VAVK+IDKT+L++ + LF+EVR MK++ HP
Sbjct: 18 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 77
Query: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
NIV+L+EVI+T+ LYL++E GG++FDY++ H + E A+ F QIV A+ YCH+
Sbjct: 78 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCHQK 136
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
+VHRDLK EN++ + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD
Sbjct: 137 FIVHRDLKAENLL-LDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 195
Query: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
P VD+WSLGVIL+ LV G PF N E ++ KY +P ++S +C++L+ + L +
Sbjct: 196 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 255
Query: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312
P +R +LE+I W+ G + Y PL YK+ E +++ R+
Sbjct: 256 PSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREE 308
Query: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372
I ++L RYN + ATY LL + E E T + P
Sbjct: 309 IQDSLVGQRYNEVMATYLLLGYK----SSELEGDTITLKPR------------------- 345
Query: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432
+ L++++ P + SV + + D AGPA+ T S
Sbjct: 346 -----PSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ---------AGPAIPTSNSYSK 391
Query: 433 KPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEE 492
K ++ + + EED E + S + +V P + + T+ P N +
Sbjct: 392 KTQSNNAE-----NKRPEEDRESGRKASSTAKVPASPLPGLERKKTT--PTPSTNSVLST 444
Query: 493 GESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRR 552
+ P L R AS G + + GS S++ S S +R
Sbjct: 445 STNRSRNS------PLLER-----ASLGQASIQNGKDSLTMPGSRASTASASAAVSAARP 493
Query: 553 RLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSENNAGGGSPSSGS 612
R + S + S H +S PP +PS A V ASPS +N S S
Sbjct: 494 RQHQKS-MSASVHPNKASGLPPTE--SNCEVPRPSTAPQRVPVASPSAHNI------SSS 544
Query: 613 GGNPTNTS 620
GG P T+
Sbjct: 545 GGAPDRTN 552
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 273 bits (697), Expect = 6e-73
Identities = 173/510 (33%), Positives = 270/510 (52%), Gaps = 30/510 (5%)
Query: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
G YD++ TLG+G+FAVVKL RH T +VA+K+IDK++LD + +++EV+ MK++ HP
Sbjct: 18 GFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHP 77
Query: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
+I++LY+V++T++ LYL+ E G++FDY+ H LNE A++ F QI+ A+ YCH
Sbjct: 78 HIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGR-LNESEARRKFWQILSAVDYCHGR 136
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
+VHRDLK EN++ +K+ DFGF N F+ G+ L T CGS Y+APE+ G +Y+
Sbjct: 137 KIVHRDLKAENLLLDNNMN-IKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEG 195
Query: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
P +DIWS+GV+L++LVCG PF +++ ++ +P +S++C+ LI RML D
Sbjct: 196 PQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLD 255
Query: 254 PKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAI 313
P +R ++ +I+ H W+ ++ P S E N + R++ D+
Sbjct: 256 PSKRLTIAQIKEHKWML-IEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKT 314
Query: 314 VEALETNRYNHITATYFLLAERILREKQ----EKEIQTRSASPSNIKAQFRQSWPTKIDV 369
+E+L+ YNH A YFLL ER+ + E+ + R PS I Q T + +
Sbjct: 315 IESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQT-VGL 373
Query: 370 PQDLEDDLTATPLSHATVPQ-SPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVP 428
P + L A +PQ S A +G +++ + D P++ G L VP
Sbjct: 374 PVTMHSP-NMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVP 432
Query: 429 PASLK------PTASGRKCLFRVEEDEEEDEEDKK---PMSLSTQVVLRRK--PSVTNRL 477
P ++ P+ + E E E EED ST+ RR VTN+L
Sbjct: 433 PVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQL 492
Query: 478 TSRKSAPVLNQIFEEGES------DDEFDM 501
P +IF +S D E+DM
Sbjct: 493 V---VMPGAGKIFSMNDSPSLDSVDSEYDM 519
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 272 bits (696), Expect = 7e-73
Identities = 206/650 (31%), Positives = 311/650 (47%), Gaps = 64/650 (9%)
Query: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
G Y L +T+G+G+FA VKLARH+ TG +VA+K+IDKT+L+ + LF+EVR MK + HP
Sbjct: 57 GNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHP 116
Query: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
NIV+L+EVI+T+ LYL++E G++FDY++ H + E A+ F QIV A+ YCH+
Sbjct: 117 NIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGR-MKEKEARAKFRQIVSAVHYCHQK 175
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
++VHRDLK EN++ + + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD
Sbjct: 176 NIVHRDLKAENLLL-DAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDG 234
Query: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
P VDIWSLGVIL+ LV G PF N E ++ KY VP ++S +C+ ++ R L +
Sbjct: 235 PEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLN 294
Query: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312
P +R +LE+I W+ G + Y P + + E +++G R+
Sbjct: 295 PAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIE-------VMVGMGYTREE 347
Query: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372
I E+L + +YN +TATY LL ++ +E R A P A+ R
Sbjct: 348 IKESLTSQKYNEVTATYLLLG------RKTEEGGDRGA-PGLALARVRAP---------- 390
Query: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432
D T S T R++ S + R + GP+ + + P
Sbjct: 391 -SDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHS-----------DFCGPSPAPLHPKR- 437
Query: 433 KPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEE 492
PT++G E + +E+ + S ST R ++ + S P +I E
Sbjct: 438 SPTSTG-------EAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPER 490
Query: 493 GESDDEFDMDENLPPKLSRLKMNIAS---PGTVHKRY-HRRKSQGRGS-----SCSSSET 543
+ D NLPP + + PG K G+ + SS +
Sbjct: 491 RK--DSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHS 548
Query: 544 SDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSENNA 603
S R RL + S ++H + G G GG Q+ P + +A+P
Sbjct: 549 LAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAP----L 604
Query: 604 GGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASR--SAGELVESLKLMS 651
G P + TS TRR + Q ++R S L + K+ S
Sbjct: 605 PAGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGSKIRS 654
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 271 bits (693), Expect = 2e-72
Identities = 166/467 (35%), Positives = 251/467 (53%), Gaps = 51/467 (10%)
Query: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
G Y L KT+G+G+FA VKLARH+ TG++VAVK+IDKT+L++ + LF+EVR MK++ HP
Sbjct: 51 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
Query: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
NIV+L+EVI+T+ LYL++E GG++FDY++ H + E A+ F QIV A+ YCH+
Sbjct: 111 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCHQK 169
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
+VHRDLK EN++ + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD
Sbjct: 170 FIVHRDLKAENLL-LDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
P VD+WSLGVIL+ LV G PF N E ++ KY +P ++S +C++L+ + L +
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
Query: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312
P +R +LE+I W+ G + Y PL YK+ E +++ R+
Sbjct: 289 PSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREE 341
Query: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372
I ++L RYN + ATY LL + E E T + P
Sbjct: 342 IQDSLVGQRYNEVMATYLLLGYK----SSELEGDTITLKPR------------------- 378
Query: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432
+ L++++ P + SV + + D A AGPA+ T S
Sbjct: 379 -----PSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQA--------AGPAIPTSNSYSK 425
Query: 433 KPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTS 479
K ++ + + EED E + S + +V P + + T+
Sbjct: 426 KTQSNNAE-----NKRPEEDRESGRKASSTAKVPASPLPGLERKKTT 467
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 270 bits (689), Expect = 5e-72
Identities = 171/444 (38%), Positives = 251/444 (56%), Gaps = 47/444 (10%)
Query: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
G Y L KT+G+G+FA VKLARHV TG +VAVK+IDKT+L+ + LF+EVR MK++ HP
Sbjct: 58 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 117
Query: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
NIV+L+EVI+T+ LYL++E GG++FDY++ H + E A+ F QIV A+ YCH+
Sbjct: 118 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCHQK 176
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
++VHRDLK EN++ + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD
Sbjct: 177 YIVHRDLKAENLL-LDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDG 235
Query: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
P VD+WSLGVIL+ LV G PF N E ++ KY +P ++S +C++L+ ++L +
Sbjct: 236 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLN 295
Query: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312
P +R SLE+I W+ G + Y P + + I MV A RD
Sbjct: 296 PIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKR------IDIMVTMGFA-RDE 348
Query: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372
I +AL +Y+ + ATY LL R+ E E S S N+ + R S
Sbjct: 349 INDALINQKYDEVMATYILLG----RKPPEFE-GGESLSSGNLCQRSRPS---------- 393
Query: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432
+ L+++T+ QSPA L RS + + K+ + AGP++ +
Sbjct: 394 -------SDLNNSTL-QSPAH-----LKVQRS--ISANQKQRRFSDHAGPSIPPAVSYTK 438
Query: 433 KPTASGRKCLFRVEEDEEEDEEDK 456
+P A+ E E+++E DK
Sbjct: 439 RPQANS-------VESEQKEEWDK 455
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 269 bits (688), Expect = 6e-72
Identities = 165/467 (35%), Positives = 250/467 (53%), Gaps = 52/467 (11%)
Query: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
G Y L KT+G+G+FA VKLARH+ TG++VAVK+IDKT+L++ + LF+EVR MK++ HP
Sbjct: 51 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
Query: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
NIV+L+EVI+T+ LYL++E GG++FDY++ H + E A+ F QIV A+ YCH+
Sbjct: 111 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCHQK 169
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
+VHRDLK EN++ + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD
Sbjct: 170 FIVHRDLKAENLL-LDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
P VD+WSLGVIL+ LV G PF N E ++ KY +P ++S +C++L+ + L +
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
Query: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312
P +R +LE+I W+ G + Y PL YK+ E +++ R+
Sbjct: 289 PSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREE 341
Query: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372
I ++L RYN + ATY LL + E E T + P
Sbjct: 342 IQDSLVGQRYNEVMATYLLLGYK----SSELEGDTITLKPR------------------- 378
Query: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432
+ L++++ P + SV + + D AGPA+ T S
Sbjct: 379 -----PSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ---------AGPAIPTSNSYSK 424
Query: 433 KPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTS 479
K ++ + + EED E + S + +V P + + T+
Sbjct: 425 KTQSNNAE-----NKRPEEDRESGRKASSTAKVPASPLPGLERKKTT 466
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 269 bits (688), Expect = 6e-72
Identities = 165/467 (35%), Positives = 250/467 (53%), Gaps = 52/467 (11%)
Query: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
G Y L KT+G+G+FA VKLARH+ TG++VAVK+IDKT+L++ + LF+EVR MK++ HP
Sbjct: 51 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
Query: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
NIV+L+EVI+T+ LYL++E GG++FDY++ H + E A+ F QIV A+ YCH+
Sbjct: 111 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCHQK 169
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
+VHRDLK EN++ + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD
Sbjct: 170 FIVHRDLKAENLL-LDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
P VD+WSLGVIL+ LV G PF N E ++ KY +P ++S +C++L+ + L +
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
Query: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312
P +R +LE+I W+ G + Y PL YK+ E +++ R+
Sbjct: 289 PSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREE 341
Query: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372
I ++L RYN + ATY LL + E E T + P
Sbjct: 342 IQDSLVGQRYNEVMATYLLLGYK----SSELEGDTITLKPR------------------- 378
Query: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432
+ L++++ P + SV + + D AGPA+ T S
Sbjct: 379 -----PSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ---------AGPAIPTSNSYSK 424
Query: 433 KPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTS 479
K ++ + + EED E + S + +V P + + T+
Sbjct: 425 KTQSNNAE-----NKRPEEDRESGRKASSTAKVPASPLPGLERKKTT 466
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 268 bits (685), Expect = 1e-71
Identities = 143/346 (41%), Positives = 214/346 (61%), Gaps = 10/346 (2%)
Query: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
G Y L KT+G+G+FA VKLARH+ TG +VA+K+IDKT+L+ + LF+EVR MK++ HP
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
NIV+L+EVI+T+ LYLI+E GG++FDY++ H + E A+ F QIV A+ YCH+
Sbjct: 114 NIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR-MKEKEARSKFRQIVSAVQYCHQK 172
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
+VHRDLK EN++ + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD
Sbjct: 173 RIVHRDLKAENLL-LDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
P VD+WSLGVIL+ LV G PF N E ++ KY +P ++S +C++L+ R L +
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
Query: 254 PKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYK-NLSEEEHNSIIQRMVLGDIADRDA 312
P +R +LE+I W+ K P V + ++S+++ I ++G ++
Sbjct: 292 PIKRGTLEQIMKDRWINAGHEEDELK---PFVEPELDISDQKRIDI----MVGMGYSQEE 344
Query: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQ 358
I E+L +Y+ ITATY LL + + ++ + + K Q
Sbjct: 345 IQESLSKMKYDEITATYLLLGRKSSEVRPSSDLNNSTGQSPHHKVQ 390
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 268 bits (685), Expect = 1e-71
Identities = 148/350 (42%), Positives = 218/350 (62%), Gaps = 14/350 (4%)
Query: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
G Y L KT+G+G+FA VKLARH+ TG +VA+K+IDKT+L+ + LF+EVR MK++ HP
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
NIV+L+EVI+T+ LYLI+E GG++FDY++ H + E A+ F QIV A+ YCH+
Sbjct: 114 NIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR-MKEKEARSKFRQIVSAVQYCHQK 172
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
+VHRDLK EN++ + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD
Sbjct: 173 RIVHRDLKAENLL-LDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
P VD+WSLGVIL+ LV G PF N E ++ KY +P ++S +C++L+ R L +
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
Query: 254 PKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYK-NLSEEEHNSIIQRMVLGDIADRDA 312
P +R +LE+I W+ K P V + ++S+++ I ++G ++
Sbjct: 292 PIKRGTLEQIMKDRWINAGHEEDELK---PFVEPELDISDQKRIDI----MVGMGYSQEE 344
Query: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQS 362
I E+L +Y+ ITATY LL R+ E + S+S + A+ R S
Sbjct: 345 IQESLSKMKYDEITATYLLLG----RKSSELDASDSSSSSNLSLAKVRPS 390
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 268 bits (685), Expect = 1e-71
Identities = 148/350 (42%), Positives = 218/350 (62%), Gaps = 14/350 (4%)
Query: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
G Y L KT+G+G+FA VKLARH+ TG +VA+K+IDKT+L+ + LF+EVR MK++ HP
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
NIV+L+EVI+T+ LYLI+E GG++FDY++ H + E A+ F QIV A+ YCH+
Sbjct: 114 NIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR-MKEKEARSKFRQIVSAVQYCHQK 172
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
+VHRDLK EN++ + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD
Sbjct: 173 RIVHRDLKAENLL-LDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
P VD+WSLGVIL+ LV G PF N E ++ KY +P ++S +C++L+ R L +
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
Query: 254 PKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYK-NLSEEEHNSIIQRMVLGDIADRDA 312
P +R +LE+I W+ K P V + ++S+++ I ++G ++
Sbjct: 292 PIKRGTLEQIMKDRWINAGHEEDELK---PFVEPELDISDQKRIDI----MVGMGYSQEE 344
Query: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQS 362
I E+L +Y+ ITATY LL R+ E + S+S + A+ R S
Sbjct: 345 IQESLSKMKYDEITATYLLLG----RKSSELDASDSSSSSNLSLAKVRPS 390
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 268 bits (685), Expect = 1e-71
Identities = 148/350 (42%), Positives = 218/350 (62%), Gaps = 14/350 (4%)
Query: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
G Y L KT+G+G+FA VKLARH+ TG +VA+K+IDKT+L+ + LF+EVR MK++ HP
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
NIV+L+EVI+T+ LYLI+E GG++FDY++ H + E A+ F QIV A+ YCH+
Sbjct: 114 NIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR-MKEKEARSKFRQIVSAVQYCHQK 172
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
+VHRDLK EN++ + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD
Sbjct: 173 RIVHRDLKAENLL-LDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
P VD+WSLGVIL+ LV G PF N E ++ KY +P ++S +C++L+ R L +
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
Query: 254 PKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYK-NLSEEEHNSIIQRMVLGDIADRDA 312
P +R +LE+I W+ K P V + ++S+++ I ++G ++
Sbjct: 292 PIKRGTLEQIMKDRWINAGHEEDELK---PFVEPELDISDQKRIDI----MVGMGYSQEE 344
Query: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQS 362
I E+L +Y+ ITATY LL R+ E + S+S + A+ R S
Sbjct: 345 IQESLSKMKYDEITATYLLLG----RKSSELDASDSSSSSNLSLAKVRPS 390
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 265 bits (676), Expect = 2e-70
Identities = 136/331 (41%), Positives = 209/331 (63%), Gaps = 8/331 (2%)
Query: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
G Y++D+T+G+G+FAVVK A H+ T KVA+K+IDKT+LD +F+EV+ MK++ HP
Sbjct: 6 GYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHP 65
Query: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
+I+RLY+V++T+ +YL+ E GG++FD+++ H + E A++ F QIV A+ +CH
Sbjct: 66 HIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGR-MAEKEARRKFKQIVTAVYFCHCR 124
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
++VHRDLK EN++ +K+ DFGFSN F PG+ L T CGS Y+APE+ G EYD
Sbjct: 125 NIVHRDLKAENLLLDANLN-IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDG 183
Query: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
P VDIWSLGV+L++LVCG PF + ++ K+ +P +S EC+ LI ML D
Sbjct: 184 PKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLD 243
Query: 254 PKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDI----AD 309
P +R S+E+I H W++ D P ++ + + L EE + VL + D
Sbjct: 244 PNKRLSMEQICKHKWMKLGDADP--NFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLD 301
Query: 310 RDAIVEALETNRYNHITATYFLLAERILREK 340
++ +++L ++ Y+H +A Y LL +R R K
Sbjct: 302 KEQTLQSLRSDAYDHYSAIYSLLCDRHKRHK 332
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 224 bits (572), Expect = 2e-58
Identities = 117/328 (35%), Positives = 191/328 (58%), Gaps = 8/328 (2%)
Query: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
G Y L+KTLG+G +VKL H TG+KVA+K++++ KL + +E+ +KL++HP
Sbjct: 32 GPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHP 91
Query: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
++++L++V + + LYL+LE GG++FDY++K L A+K+F QIV A+ +CH
Sbjct: 92 HVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGR-LTPKEARKFFRQIVSALDFCHSY 150
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
+ HRDLKPEN++ EK +++ DFG ++ L TSCGS Y+ PE++ G++YD
Sbjct: 151 SICHRDLKPENLLLDEKNN-IRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209
Query: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
D+WS GVILF L+ G PF + N + L + + +P + +C+ L+ M++ +
Sbjct: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269
Query: 254 PKRRASLEEIENHPWLQG----VDP--SPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDI 307
P++R SLE+I+ HPW G DP PA + + S + E + + + LG
Sbjct: 270 PEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCF 329
Query: 308 ADRDAIVEALETNRYNHITATYFLLAER 335
DR+ + L + N Y+LL +R
Sbjct: 330 RDRERLHRELRSEEENQEKMIYYLLLDR 357
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 221 bits (562), Expect = 3e-57
Identities = 114/273 (41%), Positives = 170/273 (62%), Gaps = 4/273 (1%)
Query: 5 KRGYDGKIA-GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTL-ATGHLFQ 62
K+ +DG++ G Y L TLG G F VK+ H TG KVAVK++++ K+ +L G + +
Sbjct: 4 KQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63
Query: 63 EVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQ 122
E++ +KL +HP+I++LY+VI T T ++++E GG++FDYI KH + E A++ F Q
Sbjct: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQ 122
Query: 123 IVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSA 182
I+ A+ YCH+ VVHRDLKPENV+ K+ DFG SN G+ L TSCGS Y+A
Sbjct: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAA 181
Query: 183 PEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKEC 242
PE++ G Y P VDIWS GVIL+ L+CG PF + + I + +P ++++
Sbjct: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241
Query: 243 KDLITRMLQRDPKRRASLEEIENHPWLQGVDPS 275
L+ MLQ DP +RA++++I H W + PS
Sbjct: 242 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPS 274
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 220 bits (561), Expect = 3e-57
Identities = 130/337 (38%), Positives = 195/337 (57%), Gaps = 12/337 (3%)
Query: 10 GKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKL 69
GK G Y + +G G+F+ VKL H T EKVA+K++DKTKLD L +E+ M+
Sbjct: 68 GKRIGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEK 127
Query: 70 VQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 129
+ HPNI+RLYEV++T +KL+L++E GG++F I E L+E +K F+QIV A+ +
Sbjct: 128 LHHPNIIRLYEVVETLSKLHLVMEYAGGGELFGKIST-EGKLSEPESKLIFSQIVSAVKH 186
Query: 130 CHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGD 189
H+ ++HRDLK ENV F+ VK+ DFGFS + G+ L T CGS Y+APE+ +
Sbjct: 187 MHENQIIHRDLKAENV-FYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDE 245
Query: 190 EYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRM 249
Y VDIW+LGV+L+ +V G PF+ ++ I++ Y+VP HVS+ C LI +
Sbjct: 246 HYIGIYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGV 305
Query: 250 LQRDPKRRASLEEIENHPWLQGVD-PSPATKYNIPLVSYKNLSE-----EEHNSIIQRMV 303
LQ+ P R ++ I N W+QGV P+P + + K+LSE EE N + +
Sbjct: 306 LQQIPTERYGIDCIMNDEWMQGVPYPTPLEPFQL---DPKHLSETSTLKEEENEVKSTLE 362
Query: 304 LGDIADRDAIVEALETNRYNHITATYFLLAERILREK 340
I + + I + + IT Y ++ R+ R+K
Sbjct: 363 HLGITE-EHIRNNQGRDARSSITGVYRIILHRVQRKK 398
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 220 bits (560), Expect = 4e-57
Identities = 127/338 (37%), Positives = 195/338 (57%), Gaps = 14/338 (4%)
Query: 6 RGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVR 65
+ YD ++ Y+L +T+G G FA VKLA H+ TGE VA+K++DK L + + E+
Sbjct: 2 KDYD-ELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS-DLPRIKTEIE 59
Query: 66 CMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVH 125
+K ++H +I +LY V++T K++++LE GG++FDYI+ + L+E+ + F QIV
Sbjct: 60 ALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDR-LSEEETRVVFRQIVS 118
Query: 126 AISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKK--LTTSCGSLAYSAP 183
A++Y H HRDLKPEN++F E L KL DFG K + K L T CGSLAY+AP
Sbjct: 119 AVAYVHSQGYAHRDLKPENLLFDEYHKL-KLIDFGLCAKPKGNKDYHLQTCCGSLAYAAP 177
Query: 184 EILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECK 243
E++ G Y D+WS+G++L++L+CG PF + N IM KY VP +S
Sbjct: 178 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSI 237
Query: 244 DLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLV-SYKNLSEEEHNSIIQRM 302
L+ +MLQ DPK+R S++ + NHPW+ YN P+ KN + + +
Sbjct: 238 LLLQQMLQVDPKKRISMKNLLNHPWIM-------QDYNYPVEWQSKNPFIHLDDDCVTEL 290
Query: 303 VLGDIADRDAIVEALETNRYNHITATYFLLAERILREK 340
+ +R + + + +Y+H+TATY LL + R K
Sbjct: 291 SVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGK 328
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 217 bits (553), Expect = 3e-56
Identities = 132/441 (29%), Positives = 228/441 (51%), Gaps = 27/441 (6%)
Query: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
G Y L+KTLG+G +VKL H T +KVA+K++++ KL + +E+ +KL++HP
Sbjct: 17 GPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHP 76
Query: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
++++L++V + + LYL+LE GG++FDY++K L A+K+F QI+ A+ +CH
Sbjct: 77 HVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGR-LTPKEARKFFRQIISALDFCHSH 135
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
+ HRDLKPEN++ EK +++ DFG ++ L TSCGS Y+ PE++ G++YD
Sbjct: 136 SICHRDLKPENLLLDEKNN-IRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 194
Query: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
D+WS GVILF L+ G PF + N + L + + +P + +C+ L+ M++ D
Sbjct: 195 RKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVD 254
Query: 254 PKRRASLEEIENHPWLQGVDPSPATKYNIP----LVSYKNLSEEEHNSIIQRMVLGDIAD 309
RR +LE I+ H W G P + IP + S +L + + + + LG D
Sbjct: 255 AARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRD 314
Query: 310 RDAIVEALETNRYNHITATYFLLAERILR--EKQEKEIQTRSASPSNIKAQFRQSWPTKI 367
R+ +++ L + N YFLL +R R ++++++ R+ K ++
Sbjct: 315 RNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRK---------RV 365
Query: 368 DVP--------QDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPEL 419
D P + + ++ P RA + +G RS+ + ++ L
Sbjct: 366 DSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIEMAQHGQRSRSISGASSGLSTSPL 425
Query: 420 AGPALS--TVPPASLKPTASG 438
+ P ++ P S PT G
Sbjct: 426 SSPRVTPHPSPRGSPLPTPKG 446
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 216 bits (551), Expect = 5e-56
Identities = 123/350 (35%), Positives = 200/350 (57%), Gaps = 16/350 (4%)
Query: 5 KRGYDGKIA-GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTL-ATGHLFQ 62
K+ +DG++ G Y L TLG G F VK+ +H TG KVAVK++++ K+ +L G + +
Sbjct: 15 KQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRR 74
Query: 63 EVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQ 122
E++ +KL +HP+I++LY+VI T + +++++E GG++FDYI K+ L+E +++ F Q
Sbjct: 75 EIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR-LDEKESRRLFQQ 133
Query: 123 IVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSA 182
I+ + YCH+ VVHRDLKPENV+ K+ DFG SN G+ L TSCGS Y+A
Sbjct: 134 ILSGVDYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAA 192
Query: 183 PEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKEC 242
PE++ G Y P VDIWS GVIL+ L+CG PF + + I D + P +++
Sbjct: 193 PEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV 252
Query: 243 KDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKY---NIPLVSYKNLSEEEHNSII 299
L+ MLQ DP +RA++++I H W + P KY P S + +E +
Sbjct: 253 ISLLKHMLQVDPMKRATIKDIREHEWFKQDLP----KYLFPEDPSYSSTMIDDEALKEVC 308
Query: 300 QRMVLGDIADRDAIVEALETNRYNHITATYFLLAE--RILREKQEKEIQT 347
++ + ++ + + N + + Y L+ + RI+ E ++ + T
Sbjct: 309 EKF---ECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLAT 355
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 211 bits (538), Expect = 2e-54
Identities = 123/364 (33%), Positives = 201/364 (55%), Gaps = 29/364 (7%)
Query: 5 KRGYDGKIA-GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTL-ATGHLFQ 62
K+ +DG++ G Y L TLG G F VK+ +H TG KVAVK++++ K+ +L G + +
Sbjct: 15 KQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRR 74
Query: 63 EVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKH--------------E 108
E++ +KL +HP+I++LY+VI T + +++++E GG++FDYI K+
Sbjct: 75 EIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGST 134
Query: 109 EGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPG 168
+ L+E +++ F QI+ + YCH+ VVHRDLKPENV+ K+ DFG SN G
Sbjct: 135 KELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDG 193
Query: 169 KKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIM 228
+ L TSCGS Y+APE++ G Y P VDIWS GVIL+ L+CG PF + + I
Sbjct: 194 EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKIC 253
Query: 229 DCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKY---NIPLV 285
D + P +++ L+ MLQ DP +RA++++I H W + P KY P
Sbjct: 254 DGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLP----KYLFPEDPSY 309
Query: 286 SYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAE--RILREKQEK 343
S + +E + ++ + ++ + + N + + Y L+ + RI+ E ++
Sbjct: 310 SSTMIDDEALKEVCEKF---ECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDF 366
Query: 344 EIQT 347
+ T
Sbjct: 367 YLAT 370
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 190 bits (483), Expect = 4e-48
Identities = 103/255 (40%), Positives = 153/255 (60%), Gaps = 4/255 (1%)
Query: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKL-DTLATGHLFQEVRCMKLVQHPN 74
Y+L +TLG+G + VK A F+G VA+K I K K+ D H+ +E+ M + HP+
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Query: 75 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 134
I+ +YEV + + K+ +I+E G+++DYI + L+E + +F QIV A+ YCHK
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRR-LSERETRHFFRQIVSAVHYCHKNG 173
Query: 135 VVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAP 194
VVHRDLK EN++ + +K+ DFG SN +Q K L T CGS Y++PEI+ G Y P
Sbjct: 174 VVHRDLKLENILLDDNCN-IKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGP 232
Query: 195 AVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDP 254
VD W+LGV+L+ LV G PF + + I +Y P+ S + + LI ML +P
Sbjct: 233 EVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNP 291
Query: 255 KRRASLEEIENHPWL 269
RRA++E+I NH W+
Sbjct: 292 DRRATIEDIANHWWV 306
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 186 bits (473), Expect = 5e-47
Identities = 102/255 (40%), Positives = 155/255 (60%), Gaps = 5/255 (1%)
Query: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKL-DTLATGHLFQEVRCMKLVQHPN 74
Y+ +TLG+G + VK AR +G VA+K I K K+ D H+ +E+ M + HP+
Sbjct: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111
Query: 75 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 134
I+ ++EV + +K+ +++E GD++DYI + ++ L+E A+ +F QIV A+ YCH+
Sbjct: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQ-LSEREARHFFRQIVSAVHYCHQNR 170
Query: 135 VVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAP 194
VVHRDLK EN++ + G +K+ DFG SN + GK L T CGS Y++PEI+ G Y P
Sbjct: 171 VVHRDLKLENILL-DANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGP 229
Query: 195 AVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDP 254
VD WSLGV+L++LV G PF + + I + Y P S C LI +L +P
Sbjct: 230 EVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNP 288
Query: 255 KRRASLEEIENHPWL 269
RRA+LE++ +H W+
Sbjct: 289 TRRATLEDVASHWWV 303
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 185 bits (470), Expect = 1e-46
Identities = 98/266 (36%), Positives = 157/266 (59%), Gaps = 9/266 (3%)
Query: 12 IAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQ 71
I +YD LG G F+ V LA T + VA+K I K L+ G + E+ + ++
Sbjct: 16 IRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEG-KEGSMENEIAVLHKIK 74
Query: 72 HPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCH 131
HPNIV L ++ ++ LYLI++L GG++FD I++ D ++ F Q++ A+ Y H
Sbjct: 75 HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIF-QVLDAVKYLH 133
Query: 132 KLHVVHRDLKPENVVFF--EKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGD 189
L +VHRDLKPEN++++ ++ + ++DFG S PG L+T+CG+ Y APE+L
Sbjct: 134 DLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQK 193
Query: 190 EYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPS----HVSKECKDL 245
Y + AVD WS+GVI ++L+CG PPF + ND++ I+ +Y S +S KD
Sbjct: 194 PY-SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDF 252
Query: 246 ITRMLQRDPKRRASLEEIENHPWLQG 271
I ++++DP++R + E+ HPW+ G
Sbjct: 253 IRHLMEKDPEKRFTCEQALQHPWIAG 278
>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
Length = 358
Score = 182 bits (461), Expect = 1e-45
Identities = 111/279 (39%), Positives = 167/279 (59%), Gaps = 19/279 (6%)
Query: 5 KRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDT-LATGHLFQE 63
K+GY I G+ LG+G +A VK A VAVK+ID+ K T L +E
Sbjct: 9 KKGY---IVGI-----NLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE 60
Query: 64 VRCMKLVQHPNIVRLYEVIDTQT-KLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQ 122
+ + V H +I++ YE+ +T ++Y+I+ELG GD+ ++I K + L+ED+A+K F Q
Sbjct: 61 MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFI-KCQGALHEDVARKMFRQ 119
Query: 123 IVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKF---QPGKKLT--TSCGS 177
+ A+ YCH L +VHRDLK EN++ +K +KL+DFGFS + G+ + T CGS
Sbjct: 120 LSSAVKYCHDLDIVHRDLKCENLLL-DKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGS 178
Query: 178 LAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVP-- 235
AY+APE+L Y DIWSLGVIL+++VCG P+ +++ + L + + + P
Sbjct: 179 AAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRS 238
Query: 236 SHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDP 274
+++ ECKDLI RMLQ D +R ++EI +H WLQ P
Sbjct: 239 KNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKP 277
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 180 bits (457), Expect = 4e-45
Identities = 95/267 (35%), Positives = 158/267 (59%), Gaps = 11/267 (4%)
Query: 12 IAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQ 71
I +++ +TLG G F+ V LA TG+ AVK I K L + + E+ ++ ++
Sbjct: 19 IKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESS-IENEIAVLRKIK 77
Query: 72 HPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGL-NEDLAKKYFAQIVHAISYC 130
H NIV L ++ ++ LYL+++L GG++FD I+ E+G E A Q++ A+ Y
Sbjct: 78 HENIVALEDIYESPNHLYLVMQLVSGGELFDRIV--EKGFYTEKDASTLIRQVLDAVYYL 135
Query: 131 HKLHVVHRDLKPENVVFF--EKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLG 188
H++ +VHRDLKPEN++++ +++ + ++DFG S G ++T+CG+ Y APE+L
Sbjct: 136 HRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQ 195
Query: 189 DEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPS----HVSKECKD 244
Y + AVD WS+GVI ++L+CG PPF + NDS+ I+ +Y S +S KD
Sbjct: 196 KPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKD 254
Query: 245 LITRMLQRDPKRRASLEEIENHPWLQG 271
I ++++DP +R + E+ HPW+ G
Sbjct: 255 FIRNLMEKDPNKRYTCEQAARHPWIAG 281
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 180 bits (457), Expect = 4e-45
Identities = 95/267 (35%), Positives = 158/267 (59%), Gaps = 11/267 (4%)
Query: 12 IAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQ 71
I +++ +TLG G F+ V LA TG+ AVK I K L + + E+ ++ ++
Sbjct: 19 IKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESS-IENEIAVLRKIK 77
Query: 72 HPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGL-NEDLAKKYFAQIVHAISYC 130
H NIV L ++ ++ LYL+++L GG++FD I+ E+G E A Q++ A+ Y
Sbjct: 78 HENIVALEDIYESPNHLYLVMQLVSGGELFDRIV--EKGFYTEKDASTLIRQVLDAVYYL 135
Query: 131 HKLHVVHRDLKPENVVFF--EKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLG 188
H++ +VHRDLKPEN++++ +++ + ++DFG S G ++T+CG+ Y APE+L
Sbjct: 136 HRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQ 195
Query: 189 DEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPS----HVSKECKD 244
Y + AVD WS+GVI ++L+CG PPF + NDS+ I+ +Y S +S KD
Sbjct: 196 KPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKD 254
Query: 245 LITRMLQRDPKRRASLEEIENHPWLQG 271
I ++++DP +R + E+ HPW+ G
Sbjct: 255 FIRNLMEKDPNKRYTCEQAARHPWIAG 281
>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
Length = 367
Score = 174 bits (442), Expect = 2e-43
Identities = 105/264 (39%), Positives = 154/264 (58%), Gaps = 11/264 (4%)
Query: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDT-LATGHLFQEVRCMKLVQHPN 74
Y L LG G +A VK A VA+K+ID+ K L +E+ + ++ H +
Sbjct: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Query: 75 IVRLYEVIDTQT-KLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
I++ YE+ +T K+Y+++EL GD+ + I K L+ED A+K F Q+ AI YCH L
Sbjct: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELI-KTRGALHEDEARKKFHQLSLAIKYCHDL 130
Query: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKF---QPGKKLT--TSCGSLAYSAPEILLG 188
VVHRDLK +N++ +K +KL+DF FS + G+ T CGS AY+APE+L G
Sbjct: 131 DVVHRDLKCDNLLL-DKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQG 189
Query: 189 DEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVP--SHVSKECKDLI 246
Y DIWSLGVIL+++VCG P+ ++N + L + + + P H++ ECKDLI
Sbjct: 190 IPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLI 249
Query: 247 TRMLQRDPKRRASLEEIENHPWLQ 270
MLQ D RR ++EI +H W+Q
Sbjct: 250 YHMLQPDVNRRLHIDEILSHCWMQ 273
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,949,248
Number of Sequences: 37866
Number of extensions: 1599738
Number of successful extensions: 14475
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 653
Number of HSP's successfully gapped in prelim test: 476
Number of HSP's that attempted gapping in prelim test: 9251
Number of HSP's gapped (non-prelim): 3289
length of query: 765
length of database: 18,247,518
effective HSP length: 110
effective length of query: 655
effective length of database: 14,082,258
effective search space: 9223878990
effective search space used: 9223878990
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.