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Search of human proteins with 156105679
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156105679 presenilin 2 isoform 1 [Homo sapiens]
(448 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156105679 presenilin 2 isoform 1 [Homo sapiens] 904 0.0
gi|156105681 presenilin 2 isoform 2 [Homo sapiens] 897 0.0
gi|4506163 presenilin 1 isoform I-467 [Homo sapiens] 558 e-159
gi|195947397 presenilin 1 isoform I-463 [Homo sapiens] 553 e-157
gi|4502131 amyloid beta A4 precursor protein-binding, family B, ... 37 0.047
gi|22035554 amyloid beta A4 precursor protein-binding, family B,... 37 0.047
gi|68223315 CD47 antigen isoform 3 precursor [Homo sapiens] 36 0.081
gi|38683836 CD47 antigen isoform 2 precursor [Homo sapiens] 36 0.081
gi|4502673 CD47 antigen isoform 1 precursor [Homo sapiens] 36 0.081
gi|126362955 sodium channel, voltage-gated, type III, alpha isof... 35 0.18
gi|126362947 sodium channel, voltage-gated, type III, alpha isof... 35 0.18
gi|126362949 sodium channel, voltage-gated, type III, alpha isof... 35 0.18
gi|30581111 minor histocompatibility antigen 13 isoform 3 [Homo ... 33 0.40
gi|30581109 minor histocompatibility antigen 13 isoform 2 [Homo ... 33 0.40
gi|23308607 minor histocompatibility antigen 13 isoform 1 [Homo ... 33 0.40
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s... 33 0.40
gi|189409142 telomeric repeat binding factor 1 isoform 1 [Homo s... 33 0.68
gi|189409140 telomeric repeat binding factor 1 isoform 2 [Homo s... 33 0.68
gi|154759293 cysteine-rich hydrophobic domain 1 [Homo sapiens] 33 0.68
gi|42544161 forkhead box M1 isoform 3 [Homo sapiens] 32 0.89
gi|42544165 forkhead box M1 isoform 2 [Homo sapiens] 32 0.89
gi|42544167 forkhead box M1 isoform 1 [Homo sapiens] 32 0.89
gi|239755464 PREDICTED: similar to hCG2045708 [Homo sapiens] 32 0.89
gi|239749955 PREDICTED: similar to hCG2045708 [Homo sapiens] 32 0.89
gi|239744269 PREDICTED: hypothetical protein XP_002343109 [Homo ... 32 0.89
gi|169212742 PREDICTED: similar to hCG1654128 [Homo sapiens] 32 1.2
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ... 32 1.5
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor... 32 1.5
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor... 32 1.5
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor... 32 1.5
>gi|156105679 presenilin 2 isoform 1 [Homo sapiens]
Length = 448
Score = 904 bits (2336), Expect = 0.0
Identities = 448/448 (100%), Positives = 448/448 (100%)
Query: 1 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP 60
MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
Sbjct: 1 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP 60
Query: 61 DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI 120
DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI
Sbjct: 61 DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI 120
Query: 121 YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL 180
YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL
Sbjct: 121 YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL 180
Query: 181 FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA 240
FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA
Sbjct: 181 FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA 240
Query: 241 LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW 300
LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW
Sbjct: 241 LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW 300
Query: 301 TVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV 360
TVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV
Sbjct: 301 TVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV 360
Query: 361 KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI 420
KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI
Sbjct: 361 KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI 420
Query: 421 TFGLIFYFSTDNLVRPFMDTLASHQLYI 448
TFGLIFYFSTDNLVRPFMDTLASHQLYI
Sbjct: 421 TFGLIFYFSTDNLVRPFMDTLASHQLYI 448
>gi|156105681 presenilin 2 isoform 2 [Homo sapiens]
Length = 447
Score = 897 bits (2319), Expect = 0.0
Identities = 447/448 (99%), Positives = 447/448 (99%), Gaps = 1/448 (0%)
Query: 1 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP 60
MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
Sbjct: 1 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP 60
Query: 61 DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI 120
DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI
Sbjct: 61 DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI 120
Query: 121 YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL 180
YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL
Sbjct: 121 YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL 180
Query: 181 FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA 240
FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA
Sbjct: 181 FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA 240
Query: 241 LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW 300
LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW
Sbjct: 241 LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW 300
Query: 301 TVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV 360
TVGMAKLDPSSQGALQLPYDPEM EDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV
Sbjct: 301 TVGMAKLDPSSQGALQLPYDPEM-EDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV 359
Query: 361 KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI 420
KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI
Sbjct: 360 KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI 419
Query: 421 TFGLIFYFSTDNLVRPFMDTLASHQLYI 448
TFGLIFYFSTDNLVRPFMDTLASHQLYI
Sbjct: 420 TFGLIFYFSTDNLVRPFMDTLASHQLYI 447
>gi|4506163 presenilin 1 isoform I-467 [Homo sapiens]
Length = 467
Score = 558 bits (1438), Expect = e-159
Identities = 306/466 (65%), Positives = 345/466 (74%), Gaps = 42/466 (9%)
Query: 24 ESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVP-----GRPPGL--- 75
E P P S + Q ED + RSQ + + +E DR G P GRP G
Sbjct: 3 ELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSL-GHPEPLSNGRPQGNSRQ 61
Query: 76 --------EEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTED 127
+EELTLKYGAKHVIMLFVPVTLCM+VVVATIKSV FYT K+GQLIYTPFTED
Sbjct: 62 VVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTED 121
Query: 128 TPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIY 187
T +VGQR L+S+LN IMISVIVVMTI LVVLYKYRCYK IH WLI+SSL+LLF F++IY
Sbjct: 122 TETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIY 181
Query: 188 LGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYL 247
LGEV KTYNVA+DY T+ L +WNFG VGM+ IHWKGPL LQQAYLIMISALMALVFIKYL
Sbjct: 182 LGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYL 241
Query: 248 PEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKL 307
PEW+AW+IL ISVYDLVAVLCPKGPLRMLVETAQERNE +FPALIYSS MVW V MA+
Sbjct: 242 PEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEG 301
Query: 308 DPSSQGAL--QLPYDPE-MEEDSYDSFGE---PSYPEVFEPPLTGYPG------------ 349
DP +Q + Y+ E E +S D+ E + E +E + G
Sbjct: 302 DPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAV 361
Query: 350 EEL-------EEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLT 402
+EL E+ EERGVKLGLGDFIFYSVLVGKA+AT SGDWNTT+ACFVAILIGLCLT
Sbjct: 362 QELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLT 421
Query: 403 LLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI 448
LLLLA+FKKALPALPISITFGL+FYF+TD LV+PFMD LA HQ YI
Sbjct: 422 LLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI 467
>gi|195947397 presenilin 1 isoform I-463 [Homo sapiens]
Length = 463
Score = 553 bits (1425), Expect = e-157
Identities = 303/464 (65%), Positives = 343/464 (73%), Gaps = 42/464 (9%)
Query: 24 ESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVP---GRPPGL----- 75
E P P S + Q ED + + +N E E + R + P GRP G
Sbjct: 3 ELPAPLSYFQNAQMSEDNHLS---NTNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVV 59
Query: 76 ------EEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTP 129
+EELTLKYGAKHVIMLFVPVTLCM+VVVATIKSV FYT K+GQLIYTPFTEDT
Sbjct: 60 EQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTE 119
Query: 130 SVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLG 189
+VGQR L+S+LN IMISVIVVMTI LVVLYKYRCYK IH WLI+SSL+LLF F++IYLG
Sbjct: 120 TVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLG 179
Query: 190 EVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPE 249
EV KTYNVA+DY T+ L +WNFG VGM+ IHWKGPL LQQAYLIMISALMALVFIKYLPE
Sbjct: 180 EVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPE 239
Query: 250 WSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDP 309
W+AW+IL ISVYDLVAVLCPKGPLRMLVETAQERNE +FPALIYSS MVW V MA+ DP
Sbjct: 240 WTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDP 299
Query: 310 SSQGAL--QLPYDPE-MEEDSYDSFGE---PSYPEVFEPPLTGYPG------------EE 351
+Q + Y+ E E +S D+ E + E +E + G +E
Sbjct: 300 EAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQE 359
Query: 352 L-------EEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLL 404
L E+ EERGVKLGLGDFIFYSVLVGKA+AT SGDWNTT+ACFVAILIGLCLTLL
Sbjct: 360 LSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLL 419
Query: 405 LLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI 448
LLA+FKKALPALPISITFGL+FYF+TD LV+PFMD LA HQ YI
Sbjct: 420 LLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI 463
>gi|4502131 amyloid beta A4 precursor protein-binding, family B,
member 1 isoform E9 [Homo sapiens]
Length = 710
Score = 36.6 bits (83), Expect = 0.047
Identities = 16/41 (39%), Positives = 24/41 (58%)
Query: 36 QGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLE 76
QGP++GE A ++E EED +++ + S PG P LE
Sbjct: 144 QGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLE 184
>gi|22035554 amyloid beta A4 precursor protein-binding, family B,
member 1 isoform delta E9 [Homo sapiens]
Length = 708
Score = 36.6 bits (83), Expect = 0.047
Identities = 16/41 (39%), Positives = 24/41 (58%)
Query: 36 QGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLE 76
QGP++GE A ++E EED +++ + S PG P LE
Sbjct: 144 QGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLE 184
>gi|68223315 CD47 antigen isoform 3 precursor [Homo sapiens]
Length = 312
Score = 35.8 bits (81), Expect = 0.081
Identities = 41/201 (20%), Positives = 83/201 (41%), Gaps = 14/201 (6%)
Query: 52 NEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRF 111
++ D Y C G E + LKY V+ F P +IV+ + F
Sbjct: 101 DKSDAVSHTGNYTCEVTELTREG-ETIIELKY---RVVSWFSPNENILIVIFPIFAILLF 156
Query: 112 YTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGW 171
+ GQ + + ++ + ++L ++I+VIV++ L V +Y
Sbjct: 157 W----GQFGIKTLKYRSGGMDEKTI-ALLVAGLVITVIVIVGAILFVPGEYSLKNATGLG 211
Query: 172 LIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGM-----VCIHWKGPLV 226
LI++S +L L Y + + + + + + VG+ CI GPL+
Sbjct: 212 LIVTSTGILILLHYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLL 271
Query: 227 LQQAYLIMISALMALVFIKYL 247
+ ++ ++ L+ LV++K++
Sbjct: 272 ISGLSILALAQLLGLVYMKFV 292
>gi|38683836 CD47 antigen isoform 2 precursor [Homo sapiens]
Length = 305
Score = 35.8 bits (81), Expect = 0.081
Identities = 41/201 (20%), Positives = 83/201 (41%), Gaps = 14/201 (6%)
Query: 52 NEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRF 111
++ D Y C G E + LKY V+ F P +IV+ + F
Sbjct: 101 DKSDAVSHTGNYTCEVTELTREG-ETIIELKY---RVVSWFSPNENILIVIFPIFAILLF 156
Query: 112 YTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGW 171
+ GQ + + ++ + ++L ++I+VIV++ L V +Y
Sbjct: 157 W----GQFGIKTLKYRSGGMDEKTI-ALLVAGLVITVIVIVGAILFVPGEYSLKNATGLG 211
Query: 172 LIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGM-----VCIHWKGPLV 226
LI++S +L L Y + + + + + + VG+ CI GPL+
Sbjct: 212 LIVTSTGILILLHYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLL 271
Query: 227 LQQAYLIMISALMALVFIKYL 247
+ ++ ++ L+ LV++K++
Sbjct: 272 ISGLSILALAQLLGLVYMKFV 292
>gi|4502673 CD47 antigen isoform 1 precursor [Homo sapiens]
Length = 323
Score = 35.8 bits (81), Expect = 0.081
Identities = 41/201 (20%), Positives = 83/201 (41%), Gaps = 14/201 (6%)
Query: 52 NEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRF 111
++ D Y C G E + LKY V+ F P +IV+ + F
Sbjct: 101 DKSDAVSHTGNYTCEVTELTREG-ETIIELKY---RVVSWFSPNENILIVIFPIFAILLF 156
Query: 112 YTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGW 171
+ GQ + + ++ + ++L ++I+VIV++ L V +Y
Sbjct: 157 W----GQFGIKTLKYRSGGMDEKTI-ALLVAGLVITVIVIVGAILFVPGEYSLKNATGLG 211
Query: 172 LIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGM-----VCIHWKGPLV 226
LI++S +L L Y + + + + + + VG+ CI GPL+
Sbjct: 212 LIVTSTGILILLHYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLL 271
Query: 227 LQQAYLIMISALMALVFIKYL 247
+ ++ ++ L+ LV++K++
Sbjct: 272 ISGLSILALAQLLGLVYMKFV 292
>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
[Homo sapiens]
Length = 1951
Score = 34.7 bits (78), Expect = 0.18
Identities = 25/114 (21%), Positives = 54/114 (47%), Gaps = 4/114 (3%)
Query: 134 RLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLK 193
+ + VL+ + ++ +++ F++ L R Y F GW I ++++ ++L E+++
Sbjct: 1503 KYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIE 1562
Query: 194 TYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYL 247
Y V+ PTL + +G + KG ++ ++ +L AL I L
Sbjct: 1563 KYFVS---PTLFRVI-RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1612
>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
[Homo sapiens]
Length = 1951
Score = 34.7 bits (78), Expect = 0.18
Identities = 25/114 (21%), Positives = 54/114 (47%), Gaps = 4/114 (3%)
Query: 134 RLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLK 193
+ + VL+ + ++ +++ F++ L R Y F GW I ++++ ++L E+++
Sbjct: 1503 KYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIE 1562
Query: 194 TYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYL 247
Y V+ PTL + +G + KG ++ ++ +L AL I L
Sbjct: 1563 KYFVS---PTLFRVI-RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1612
>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
[Homo sapiens]
Length = 2000
Score = 34.7 bits (78), Expect = 0.18
Identities = 25/114 (21%), Positives = 54/114 (47%), Gaps = 4/114 (3%)
Query: 134 RLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLK 193
+ + VL+ + ++ +++ F++ L R Y F GW I ++++ ++L E+++
Sbjct: 1552 KYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIE 1611
Query: 194 TYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYL 247
Y V+ PTL + +G + KG ++ ++ +L AL I L
Sbjct: 1612 KYFVS---PTLFRVI-RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1661
>gi|30581111 minor histocompatibility antigen 13 isoform 3 [Homo
sapiens]
Length = 426
Score = 33.5 bits (75), Expect = 0.40
Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 7/84 (8%)
Query: 340 FEPPLT-GYPGEELEE--EEERGVKLGLGDF----IFYSVLVGKAAATGSGDWNTTLACF 392
FE P+ +P + LE+ E LGLGD IF ++L+ + F
Sbjct: 236 FEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSF 295
Query: 393 VAILIGLCLTLLLLAVFKKALPAL 416
A + GL LT+ ++ +FK A PAL
Sbjct: 296 AAYIFGLGLTIFIMHIFKHAQPAL 319
>gi|30581109 minor histocompatibility antigen 13 isoform 2 [Homo
sapiens]
Length = 394
Score = 33.5 bits (75), Expect = 0.40
Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 7/84 (8%)
Query: 340 FEPPLT-GYPGEELEE--EEERGVKLGLGDF----IFYSVLVGKAAATGSGDWNTTLACF 392
FE P+ +P + LE+ E LGLGD IF ++L+ + F
Sbjct: 236 FEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSF 295
Query: 393 VAILIGLCLTLLLLAVFKKALPAL 416
A + GL LT+ ++ +FK A PAL
Sbjct: 296 AAYIFGLGLTIFIMHIFKHAQPAL 319
>gi|23308607 minor histocompatibility antigen 13 isoform 1 [Homo
sapiens]
Length = 377
Score = 33.5 bits (75), Expect = 0.40
Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 7/84 (8%)
Query: 340 FEPPLT-GYPGEELEE--EEERGVKLGLGDF----IFYSVLVGKAAATGSGDWNTTLACF 392
FE P+ +P + LE+ E LGLGD IF ++L+ + F
Sbjct: 236 FEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSF 295
Query: 393 VAILIGLCLTLLLLAVFKKALPAL 416
A + GL LT+ ++ +FK A PAL
Sbjct: 296 AAYIFGLGLTIFIMHIFKHAQPAL 319
>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
sapiens]
Length = 1977
Score = 33.5 bits (75), Expect = 0.40
Identities = 32/148 (21%), Positives = 63/148 (42%), Gaps = 18/148 (12%)
Query: 100 IVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVL 159
I+V+ + V EK GQ + + VL + ++ +I+ ++ L
Sbjct: 1510 IMVLICLNMVTMMVEKEGQ--------------SQHMTEVLYWINVVFIILFTGECVLKL 1555
Query: 160 YKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCI 219
R Y F GW I ++++ ++L ++++TY V+ PTL + +G +
Sbjct: 1556 ISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVS---PTLFRVI-RLARIGRILR 1611
Query: 220 HWKGPLVLQQAYLIMISALMALVFIKYL 247
KG ++ ++ +L AL I L
Sbjct: 1612 LVKGAKGIRTLLFALMMSLPALFNIGLL 1639
>gi|189409142 telomeric repeat binding factor 1 isoform 1 [Homo
sapiens]
Length = 439
Score = 32.7 bits (73), Expect = 0.68
Identities = 18/58 (31%), Positives = 29/58 (50%), Gaps = 2/58 (3%)
Query: 21 MSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEE 78
+S+ +P+PR C +GR E A+ ++ N+E+ E + C G P EEE
Sbjct: 5 VSSAAPSPRGCADGRDADPTEEQMAE--TERNDEEQFECQELLECQVQVGAPEEEEEE 60
>gi|189409140 telomeric repeat binding factor 1 isoform 2 [Homo
sapiens]
Length = 419
Score = 32.7 bits (73), Expect = 0.68
Identities = 18/58 (31%), Positives = 29/58 (50%), Gaps = 2/58 (3%)
Query: 21 MSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEE 78
+S+ +P+PR C +GR E A+ ++ N+E+ E + C G P EEE
Sbjct: 5 VSSAAPSPRGCADGRDADPTEEQMAE--TERNDEEQFECQELLECQVQVGAPEEEEEE 60
>gi|154759293 cysteine-rich hydrophobic domain 1 [Homo sapiens]
Length = 224
Score = 32.7 bits (73), Expect = 0.68
Identities = 23/84 (27%), Positives = 38/84 (45%), Gaps = 7/84 (8%)
Query: 7 SDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCS 66
S+ EEE +E + S+ SP+ S G E+ E + +E EE+ EE+ +
Sbjct: 15 SELEEE--EEEEAATSSSSPSSSSSVSGPDDDEEDEEEEEEEEEEEEEEEEEEEEE---- 68
Query: 67 GVPGRPPGLEEELTLKYGAKHVIM 90
P P + EE +Y V++
Sbjct: 69 -APPPPRVVSEEHLRRYAPDPVLV 91
>gi|42544161 forkhead box M1 isoform 3 [Homo sapiens]
Length = 748
Score = 32.3 bits (72), Expect = 0.89
Identities = 13/39 (33%), Positives = 21/39 (53%), Gaps = 3/39 (7%)
Query: 51 ENEEDGEEDPDRYV---CSGVPGRPPGLEEELTLKYGAK 86
+ +E G P++++ C G P +PPGL + Y AK
Sbjct: 94 KGKESGSSGPNKFILISCGGAPTQPPGLRPQTQTSYDAK 132
>gi|42544165 forkhead box M1 isoform 2 [Homo sapiens]
Length = 763
Score = 32.3 bits (72), Expect = 0.89
Identities = 13/39 (33%), Positives = 21/39 (53%), Gaps = 3/39 (7%)
Query: 51 ENEEDGEEDPDRYV---CSGVPGRPPGLEEELTLKYGAK 86
+ +E G P++++ C G P +PPGL + Y AK
Sbjct: 94 KGKESGSSGPNKFILISCGGAPTQPPGLRPQTQTSYDAK 132
>gi|42544167 forkhead box M1 isoform 1 [Homo sapiens]
Length = 801
Score = 32.3 bits (72), Expect = 0.89
Identities = 13/39 (33%), Positives = 21/39 (53%), Gaps = 3/39 (7%)
Query: 51 ENEEDGEEDPDRYV---CSGVPGRPPGLEEELTLKYGAK 86
+ +E G P++++ C G P +PPGL + Y AK
Sbjct: 94 KGKESGSSGPNKFILISCGGAPTQPPGLRPQTQTSYDAK 132
>gi|239755464 PREDICTED: similar to hCG2045708 [Homo sapiens]
Length = 445
Score = 32.3 bits (72), Expect = 0.89
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 9/64 (14%)
Query: 9 SEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP--DRYVCS 66
+++EVC E+ L ++ P PRS P+ G + R Q + G DP +
Sbjct: 94 ADKEVCPEKRKLTESDVPFPRS-------PDHGSPKLEQRLQSCSQRGAGDPYAPKVTSP 146
Query: 67 GVPG 70
G+PG
Sbjct: 147 GIPG 150
>gi|239749955 PREDICTED: similar to hCG2045708 [Homo sapiens]
Length = 445
Score = 32.3 bits (72), Expect = 0.89
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 9/64 (14%)
Query: 9 SEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP--DRYVCS 66
+++EVC E+ L ++ P PRS P+ G + R Q + G DP +
Sbjct: 94 ADKEVCPEKRKLTESDVPFPRS-------PDHGSPKLEQRLQSCSQRGAGDPYAPKVTSP 146
Query: 67 GVPG 70
G+PG
Sbjct: 147 GIPG 150
>gi|239744269 PREDICTED: hypothetical protein XP_002343109 [Homo
sapiens]
Length = 445
Score = 32.3 bits (72), Expect = 0.89
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 9/64 (14%)
Query: 9 SEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP--DRYVCS 66
+++EVC E+ L ++ P PRS P+ G + R Q + G DP +
Sbjct: 94 ADKEVCPEKRKLTESDVPFPRS-------PDHGSPKLEQRLQSCSQRGAGDPYAPKVTSP 146
Query: 67 GVPG 70
G+PG
Sbjct: 147 GIPG 150
>gi|169212742 PREDICTED: similar to hCG1654128 [Homo sapiens]
Length = 1015
Score = 32.0 bits (71), Expect = 1.2
Identities = 19/54 (35%), Positives = 23/54 (42%), Gaps = 1/54 (1%)
Query: 6 ASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEED 59
AS +E + E A SPT + GPED T + EEDG ED
Sbjct: 324 ASPTEHGIDQEEDGPEDA-SPTEHGVDQEEDGPEDASPTEHEHGVDQEEDGPED 376
Score = 30.0 bits (66), Expect = 4.4
Identities = 25/79 (31%), Positives = 33/79 (41%), Gaps = 4/79 (5%)
Query: 6 ASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVC 65
AS +E +V E A SPT + GPED T + +EDG ED R
Sbjct: 239 ASPTEHDVGQEEDGPEDA-SPTEHGVDQQEDGPEDASPTE--HGVDQQEDGPEDA-RPTE 294
Query: 66 SGVPGRPPGLEEELTLKYG 84
GV G E+ ++G
Sbjct: 295 HGVDQEEDGPEDASLTEHG 313
>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
sapiens]
Length = 1998
Score = 31.6 bits (70), Expect = 1.5
Identities = 23/112 (20%), Positives = 53/112 (47%), Gaps = 4/112 (3%)
Query: 136 LNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTY 195
+ ++L+ + ++ +++ ++ L R Y F GW I ++++ ++L E+++ Y
Sbjct: 1558 VTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKY 1617
Query: 196 NVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYL 247
V+ PTL + +G + KG ++ ++ +L AL I L
Sbjct: 1618 FVS---PTLFRVI-RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1665
>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
[Homo sapiens]
Length = 2005
Score = 31.6 bits (70), Expect = 1.5
Identities = 32/177 (18%), Positives = 71/177 (40%), Gaps = 25/177 (14%)
Query: 71 RPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPS 130
RP + + + K V + + + +C+ +V + +T
Sbjct: 1515 RPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV--------------------ETDD 1554
Query: 131 VGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGE 190
Q + N +L + ++ +++ ++ L R Y F GW I ++++ ++L E
Sbjct: 1555 QSQEMTN-ILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAE 1613
Query: 191 VLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYL 247
+++ Y V+ PTL + +G + KG ++ ++ +L AL I L
Sbjct: 1614 LIEKYFVS---PTLFRVI-RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1666
>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 31.6 bits (70), Expect = 1.5
Identities = 32/177 (18%), Positives = 71/177 (40%), Gaps = 25/177 (14%)
Query: 71 RPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPS 130
RP + + + K V + + + +C+ +V + +T
Sbjct: 1515 RPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV--------------------ETDD 1554
Query: 131 VGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGE 190
Q + N +L + ++ +++ ++ L R Y F GW I ++++ ++L E
Sbjct: 1555 QSQEMTN-ILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAE 1613
Query: 191 VLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYL 247
+++ Y V+ PTL + +G + KG ++ ++ +L AL I L
Sbjct: 1614 LIEKYFVS---PTLFRVI-RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1666
>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 31.6 bits (70), Expect = 1.5
Identities = 32/177 (18%), Positives = 71/177 (40%), Gaps = 25/177 (14%)
Query: 71 RPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPS 130
RP + + + K V + + + +C+ +V + +T
Sbjct: 1515 RPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV--------------------ETDD 1554
Query: 131 VGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGE 190
Q + N +L + ++ +++ ++ L R Y F GW I ++++ ++L E
Sbjct: 1555 QSQEMTN-ILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAE 1613
Query: 191 VLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYL 247
+++ Y V+ PTL + +G + KG ++ ++ +L AL I L
Sbjct: 1614 LIEKYFVS---PTLFRVI-RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1666
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,119,396
Number of Sequences: 37866
Number of extensions: 867783
Number of successful extensions: 3850
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 3705
Number of HSP's gapped (non-prelim): 180
length of query: 448
length of database: 18,247,518
effective HSP length: 106
effective length of query: 342
effective length of database: 14,233,722
effective search space: 4867932924
effective search space used: 4867932924
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.