Guide to the Human Genome
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Search of human proteins with 156105679

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|156105679 presenilin 2 isoform 1 [Homo sapiens]
         (448 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|156105679 presenilin 2 isoform 1 [Homo sapiens]                    904   0.0  
gi|156105681 presenilin 2 isoform 2 [Homo sapiens]                    897   0.0  
gi|4506163 presenilin 1 isoform I-467 [Homo sapiens]                  558   e-159
gi|195947397 presenilin 1 isoform I-463 [Homo sapiens]                553   e-157
gi|4502131 amyloid beta A4 precursor protein-binding, family B, ...    37   0.047
gi|22035554 amyloid beta A4 precursor protein-binding, family B,...    37   0.047
gi|68223315 CD47 antigen isoform 3 precursor [Homo sapiens]            36   0.081
gi|38683836 CD47 antigen isoform 2 precursor [Homo sapiens]            36   0.081
gi|4502673 CD47 antigen isoform 1 precursor [Homo sapiens]             36   0.081
gi|126362955 sodium channel, voltage-gated, type III, alpha isof...    35   0.18 
gi|126362947 sodium channel, voltage-gated, type III, alpha isof...    35   0.18 
gi|126362949 sodium channel, voltage-gated, type III, alpha isof...    35   0.18 
gi|30581111 minor histocompatibility antigen 13 isoform 3 [Homo ...    33   0.40 
gi|30581109 minor histocompatibility antigen 13 isoform 2 [Homo ...    33   0.40 
gi|23308607 minor histocompatibility antigen 13 isoform 1 [Homo ...    33   0.40 
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s...    33   0.40 
gi|189409142 telomeric repeat binding factor 1 isoform 1 [Homo s...    33   0.68 
gi|189409140 telomeric repeat binding factor 1 isoform 2 [Homo s...    33   0.68 
gi|154759293 cysteine-rich hydrophobic domain 1 [Homo sapiens]         33   0.68 
gi|42544161 forkhead box M1 isoform 3 [Homo sapiens]                   32   0.89 
gi|42544165 forkhead box M1 isoform 2 [Homo sapiens]                   32   0.89 
gi|42544167 forkhead box M1 isoform 1 [Homo sapiens]                   32   0.89 
gi|239755464 PREDICTED: similar to hCG2045708 [Homo sapiens]           32   0.89 
gi|239749955 PREDICTED: similar to hCG2045708 [Homo sapiens]           32   0.89 
gi|239744269 PREDICTED: hypothetical protein XP_002343109 [Homo ...    32   0.89 
gi|169212742 PREDICTED: similar to hCG1654128 [Homo sapiens]           32   1.2  
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ...    32   1.5  
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor...    32   1.5  
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor...    32   1.5  
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor...    32   1.5  

>gi|156105679 presenilin 2 isoform 1 [Homo sapiens]
          Length = 448

 Score =  904 bits (2336), Expect = 0.0
 Identities = 448/448 (100%), Positives = 448/448 (100%)

Query: 1   MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP 60
           MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
Sbjct: 1   MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP 60

Query: 61  DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI 120
           DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI
Sbjct: 61  DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI 120

Query: 121 YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL 180
           YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL
Sbjct: 121 YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL 180

Query: 181 FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA 240
           FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA
Sbjct: 181 FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA 240

Query: 241 LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW 300
           LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW
Sbjct: 241 LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW 300

Query: 301 TVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV 360
           TVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV
Sbjct: 301 TVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV 360

Query: 361 KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI 420
           KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI
Sbjct: 361 KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI 420

Query: 421 TFGLIFYFSTDNLVRPFMDTLASHQLYI 448
           TFGLIFYFSTDNLVRPFMDTLASHQLYI
Sbjct: 421 TFGLIFYFSTDNLVRPFMDTLASHQLYI 448


>gi|156105681 presenilin 2 isoform 2 [Homo sapiens]
          Length = 447

 Score =  897 bits (2319), Expect = 0.0
 Identities = 447/448 (99%), Positives = 447/448 (99%), Gaps = 1/448 (0%)

Query: 1   MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP 60
           MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
Sbjct: 1   MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP 60

Query: 61  DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI 120
           DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI
Sbjct: 61  DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI 120

Query: 121 YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL 180
           YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL
Sbjct: 121 YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL 180

Query: 181 FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA 240
           FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA
Sbjct: 181 FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA 240

Query: 241 LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW 300
           LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW
Sbjct: 241 LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW 300

Query: 301 TVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV 360
           TVGMAKLDPSSQGALQLPYDPEM EDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV
Sbjct: 301 TVGMAKLDPSSQGALQLPYDPEM-EDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV 359

Query: 361 KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI 420
           KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI
Sbjct: 360 KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI 419

Query: 421 TFGLIFYFSTDNLVRPFMDTLASHQLYI 448
           TFGLIFYFSTDNLVRPFMDTLASHQLYI
Sbjct: 420 TFGLIFYFSTDNLVRPFMDTLASHQLYI 447


>gi|4506163 presenilin 1 isoform I-467 [Homo sapiens]
          Length = 467

 Score =  558 bits (1438), Expect = e-159
 Identities = 306/466 (65%), Positives = 345/466 (74%), Gaps = 42/466 (9%)

Query: 24  ESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVP-----GRPPGL--- 75
           E P P S  +  Q  ED   +   RSQ +  + +E  DR    G P     GRP G    
Sbjct: 3   ELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSL-GHPEPLSNGRPQGNSRQ 61

Query: 76  --------EEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTED 127
                   +EELTLKYGAKHVIMLFVPVTLCM+VVVATIKSV FYT K+GQLIYTPFTED
Sbjct: 62  VVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTED 121

Query: 128 TPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIY 187
           T +VGQR L+S+LN  IMISVIVVMTI LVVLYKYRCYK IH WLI+SSL+LLF F++IY
Sbjct: 122 TETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIY 181

Query: 188 LGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYL 247
           LGEV KTYNVA+DY T+ L +WNFG VGM+ IHWKGPL LQQAYLIMISALMALVFIKYL
Sbjct: 182 LGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYL 241

Query: 248 PEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKL 307
           PEW+AW+IL  ISVYDLVAVLCPKGPLRMLVETAQERNE +FPALIYSS MVW V MA+ 
Sbjct: 242 PEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEG 301

Query: 308 DPSSQGAL--QLPYDPE-MEEDSYDSFGE---PSYPEVFEPPLTGYPG------------ 349
           DP +Q  +     Y+ E  E +S D+  E     + E +E     + G            
Sbjct: 302 DPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAV 361

Query: 350 EEL-------EEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLT 402
           +EL       E+ EERGVKLGLGDFIFYSVLVGKA+AT SGDWNTT+ACFVAILIGLCLT
Sbjct: 362 QELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLT 421

Query: 403 LLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI 448
           LLLLA+FKKALPALPISITFGL+FYF+TD LV+PFMD LA HQ YI
Sbjct: 422 LLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI 467


>gi|195947397 presenilin 1 isoform I-463 [Homo sapiens]
          Length = 463

 Score =  553 bits (1425), Expect = e-157
 Identities = 303/464 (65%), Positives = 343/464 (73%), Gaps = 42/464 (9%)

Query: 24  ESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVP---GRPPGL----- 75
           E P P S  +  Q  ED   +    + +N E  E +  R +    P   GRP G      
Sbjct: 3   ELPAPLSYFQNAQMSEDNHLS---NTNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVV 59

Query: 76  ------EEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTP 129
                 +EELTLKYGAKHVIMLFVPVTLCM+VVVATIKSV FYT K+GQLIYTPFTEDT 
Sbjct: 60  EQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTE 119

Query: 130 SVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLG 189
           +VGQR L+S+LN  IMISVIVVMTI LVVLYKYRCYK IH WLI+SSL+LLF F++IYLG
Sbjct: 120 TVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLG 179

Query: 190 EVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPE 249
           EV KTYNVA+DY T+ L +WNFG VGM+ IHWKGPL LQQAYLIMISALMALVFIKYLPE
Sbjct: 180 EVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPE 239

Query: 250 WSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDP 309
           W+AW+IL  ISVYDLVAVLCPKGPLRMLVETAQERNE +FPALIYSS MVW V MA+ DP
Sbjct: 240 WTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDP 299

Query: 310 SSQGAL--QLPYDPE-MEEDSYDSFGE---PSYPEVFEPPLTGYPG------------EE 351
            +Q  +     Y+ E  E +S D+  E     + E +E     + G            +E
Sbjct: 300 EAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQE 359

Query: 352 L-------EEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLL 404
           L       E+ EERGVKLGLGDFIFYSVLVGKA+AT SGDWNTT+ACFVAILIGLCLTLL
Sbjct: 360 LSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLL 419

Query: 405 LLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI 448
           LLA+FKKALPALPISITFGL+FYF+TD LV+PFMD LA HQ YI
Sbjct: 420 LLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI 463


>gi|4502131 amyloid beta A4 precursor protein-binding, family B,
           member 1 isoform E9 [Homo sapiens]
          Length = 710

 Score = 36.6 bits (83), Expect = 0.047
 Identities = 16/41 (39%), Positives = 24/41 (58%)

Query: 36  QGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLE 76
           QGP++GE  A   ++E EED +++ +    S  PG P  LE
Sbjct: 144 QGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLE 184


>gi|22035554 amyloid beta A4 precursor protein-binding, family B,
           member 1 isoform delta E9 [Homo sapiens]
          Length = 708

 Score = 36.6 bits (83), Expect = 0.047
 Identities = 16/41 (39%), Positives = 24/41 (58%)

Query: 36  QGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLE 76
           QGP++GE  A   ++E EED +++ +    S  PG P  LE
Sbjct: 144 QGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLE 184


>gi|68223315 CD47 antigen isoform 3 precursor [Homo sapiens]
          Length = 312

 Score = 35.8 bits (81), Expect = 0.081
 Identities = 41/201 (20%), Positives = 83/201 (41%), Gaps = 14/201 (6%)

Query: 52  NEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRF 111
           ++ D       Y C        G E  + LKY    V+  F P    +IV+      + F
Sbjct: 101 DKSDAVSHTGNYTCEVTELTREG-ETIIELKY---RVVSWFSPNENILIVIFPIFAILLF 156

Query: 112 YTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGW 171
           +    GQ         +  + ++ + ++L   ++I+VIV++   L V  +Y         
Sbjct: 157 W----GQFGIKTLKYRSGGMDEKTI-ALLVAGLVITVIVIVGAILFVPGEYSLKNATGLG 211

Query: 172 LIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGM-----VCIHWKGPLV 226
           LI++S  +L L  Y      +   +  +    + +  +    VG+      CI   GPL+
Sbjct: 212 LIVTSTGILILLHYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLL 271

Query: 227 LQQAYLIMISALMALVFIKYL 247
           +    ++ ++ L+ LV++K++
Sbjct: 272 ISGLSILALAQLLGLVYMKFV 292


>gi|38683836 CD47 antigen isoform 2 precursor [Homo sapiens]
          Length = 305

 Score = 35.8 bits (81), Expect = 0.081
 Identities = 41/201 (20%), Positives = 83/201 (41%), Gaps = 14/201 (6%)

Query: 52  NEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRF 111
           ++ D       Y C        G E  + LKY    V+  F P    +IV+      + F
Sbjct: 101 DKSDAVSHTGNYTCEVTELTREG-ETIIELKY---RVVSWFSPNENILIVIFPIFAILLF 156

Query: 112 YTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGW 171
           +    GQ         +  + ++ + ++L   ++I+VIV++   L V  +Y         
Sbjct: 157 W----GQFGIKTLKYRSGGMDEKTI-ALLVAGLVITVIVIVGAILFVPGEYSLKNATGLG 211

Query: 172 LIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGM-----VCIHWKGPLV 226
           LI++S  +L L  Y      +   +  +    + +  +    VG+      CI   GPL+
Sbjct: 212 LIVTSTGILILLHYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLL 271

Query: 227 LQQAYLIMISALMALVFIKYL 247
           +    ++ ++ L+ LV++K++
Sbjct: 272 ISGLSILALAQLLGLVYMKFV 292


>gi|4502673 CD47 antigen isoform 1 precursor [Homo sapiens]
          Length = 323

 Score = 35.8 bits (81), Expect = 0.081
 Identities = 41/201 (20%), Positives = 83/201 (41%), Gaps = 14/201 (6%)

Query: 52  NEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRF 111
           ++ D       Y C        G E  + LKY    V+  F P    +IV+      + F
Sbjct: 101 DKSDAVSHTGNYTCEVTELTREG-ETIIELKY---RVVSWFSPNENILIVIFPIFAILLF 156

Query: 112 YTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGW 171
           +    GQ         +  + ++ + ++L   ++I+VIV++   L V  +Y         
Sbjct: 157 W----GQFGIKTLKYRSGGMDEKTI-ALLVAGLVITVIVIVGAILFVPGEYSLKNATGLG 211

Query: 172 LIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGM-----VCIHWKGPLV 226
           LI++S  +L L  Y      +   +  +    + +  +    VG+      CI   GPL+
Sbjct: 212 LIVTSTGILILLHYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLL 271

Query: 227 LQQAYLIMISALMALVFIKYL 247
           +    ++ ++ L+ LV++K++
Sbjct: 272 ISGLSILALAQLLGLVYMKFV 292


>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
            [Homo sapiens]
          Length = 1951

 Score = 34.7 bits (78), Expect = 0.18
 Identities = 25/114 (21%), Positives = 54/114 (47%), Gaps = 4/114 (3%)

Query: 134  RLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLK 193
            + +  VL+ + ++ +++    F++ L   R Y F  GW I   ++++     ++L E+++
Sbjct: 1503 KYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIE 1562

Query: 194  TYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYL 247
             Y V+   PTL   +     +G +    KG   ++     ++ +L AL  I  L
Sbjct: 1563 KYFVS---PTLFRVI-RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1612


>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
            [Homo sapiens]
          Length = 1951

 Score = 34.7 bits (78), Expect = 0.18
 Identities = 25/114 (21%), Positives = 54/114 (47%), Gaps = 4/114 (3%)

Query: 134  RLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLK 193
            + +  VL+ + ++ +++    F++ L   R Y F  GW I   ++++     ++L E+++
Sbjct: 1503 KYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIE 1562

Query: 194  TYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYL 247
             Y V+   PTL   +     +G +    KG   ++     ++ +L AL  I  L
Sbjct: 1563 KYFVS---PTLFRVI-RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1612


>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
            [Homo sapiens]
          Length = 2000

 Score = 34.7 bits (78), Expect = 0.18
 Identities = 25/114 (21%), Positives = 54/114 (47%), Gaps = 4/114 (3%)

Query: 134  RLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLK 193
            + +  VL+ + ++ +++    F++ L   R Y F  GW I   ++++     ++L E+++
Sbjct: 1552 KYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIE 1611

Query: 194  TYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYL 247
             Y V+   PTL   +     +G +    KG   ++     ++ +L AL  I  L
Sbjct: 1612 KYFVS---PTLFRVI-RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1661


>gi|30581111 minor histocompatibility antigen 13 isoform 3 [Homo
           sapiens]
          Length = 426

 Score = 33.5 bits (75), Expect = 0.40
 Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 7/84 (8%)

Query: 340 FEPPLT-GYPGEELEE--EEERGVKLGLGDF----IFYSVLVGKAAATGSGDWNTTLACF 392
           FE P+   +P + LE+  E      LGLGD     IF ++L+    +            F
Sbjct: 236 FEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSF 295

Query: 393 VAILIGLCLTLLLLAVFKKALPAL 416
            A + GL LT+ ++ +FK A PAL
Sbjct: 296 AAYIFGLGLTIFIMHIFKHAQPAL 319


>gi|30581109 minor histocompatibility antigen 13 isoform 2 [Homo
           sapiens]
          Length = 394

 Score = 33.5 bits (75), Expect = 0.40
 Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 7/84 (8%)

Query: 340 FEPPLT-GYPGEELEE--EEERGVKLGLGDF----IFYSVLVGKAAATGSGDWNTTLACF 392
           FE P+   +P + LE+  E      LGLGD     IF ++L+    +            F
Sbjct: 236 FEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSF 295

Query: 393 VAILIGLCLTLLLLAVFKKALPAL 416
            A + GL LT+ ++ +FK A PAL
Sbjct: 296 AAYIFGLGLTIFIMHIFKHAQPAL 319


>gi|23308607 minor histocompatibility antigen 13 isoform 1 [Homo
           sapiens]
          Length = 377

 Score = 33.5 bits (75), Expect = 0.40
 Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 7/84 (8%)

Query: 340 FEPPLT-GYPGEELEE--EEERGVKLGLGDF----IFYSVLVGKAAATGSGDWNTTLACF 392
           FE P+   +P + LE+  E      LGLGD     IF ++L+    +            F
Sbjct: 236 FEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSF 295

Query: 393 VAILIGLCLTLLLLAVFKKALPAL 416
            A + GL LT+ ++ +FK A PAL
Sbjct: 296 AAYIFGLGLTIFIMHIFKHAQPAL 319


>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
            sapiens]
          Length = 1977

 Score = 33.5 bits (75), Expect = 0.40
 Identities = 32/148 (21%), Positives = 63/148 (42%), Gaps = 18/148 (12%)

Query: 100  IVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVL 159
            I+V+  +  V    EK GQ               + +  VL  + ++ +I+     ++ L
Sbjct: 1510 IMVLICLNMVTMMVEKEGQ--------------SQHMTEVLYWINVVFIILFTGECVLKL 1555

Query: 160  YKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCI 219
               R Y F  GW I   ++++     ++L ++++TY V+   PTL   +     +G +  
Sbjct: 1556 ISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVS---PTLFRVI-RLARIGRILR 1611

Query: 220  HWKGPLVLQQAYLIMISALMALVFIKYL 247
              KG   ++     ++ +L AL  I  L
Sbjct: 1612 LVKGAKGIRTLLFALMMSLPALFNIGLL 1639


>gi|189409142 telomeric repeat binding factor 1 isoform 1 [Homo
          sapiens]
          Length = 439

 Score = 32.7 bits (73), Expect = 0.68
 Identities = 18/58 (31%), Positives = 29/58 (50%), Gaps = 2/58 (3%)

Query: 21 MSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEE 78
          +S+ +P+PR C +GR      E  A+  ++ N+E+  E  +   C    G P   EEE
Sbjct: 5  VSSAAPSPRGCADGRDADPTEEQMAE--TERNDEEQFECQELLECQVQVGAPEEEEEE 60


>gi|189409140 telomeric repeat binding factor 1 isoform 2 [Homo
          sapiens]
          Length = 419

 Score = 32.7 bits (73), Expect = 0.68
 Identities = 18/58 (31%), Positives = 29/58 (50%), Gaps = 2/58 (3%)

Query: 21 MSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEE 78
          +S+ +P+PR C +GR      E  A+  ++ N+E+  E  +   C    G P   EEE
Sbjct: 5  VSSAAPSPRGCADGRDADPTEEQMAE--TERNDEEQFECQELLECQVQVGAPEEEEEE 60


>gi|154759293 cysteine-rich hydrophobic domain 1 [Homo sapiens]
          Length = 224

 Score = 32.7 bits (73), Expect = 0.68
 Identities = 23/84 (27%), Positives = 38/84 (45%), Gaps = 7/84 (8%)

Query: 7  SDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCS 66
          S+ EEE  +E  +  S+ SP+  S   G    E+ E   +   +E EE+ EE+ +     
Sbjct: 15 SELEEE--EEEEAATSSSSPSSSSSVSGPDDDEEDEEEEEEEEEEEEEEEEEEEEE---- 68

Query: 67 GVPGRPPGLEEELTLKYGAKHVIM 90
            P  P  + EE   +Y    V++
Sbjct: 69 -APPPPRVVSEEHLRRYAPDPVLV 91


>gi|42544161 forkhead box M1 isoform 3 [Homo sapiens]
          Length = 748

 Score = 32.3 bits (72), Expect = 0.89
 Identities = 13/39 (33%), Positives = 21/39 (53%), Gaps = 3/39 (7%)

Query: 51  ENEEDGEEDPDRYV---CSGVPGRPPGLEEELTLKYGAK 86
           + +E G   P++++   C G P +PPGL  +    Y AK
Sbjct: 94  KGKESGSSGPNKFILISCGGAPTQPPGLRPQTQTSYDAK 132


>gi|42544165 forkhead box M1 isoform 2 [Homo sapiens]
          Length = 763

 Score = 32.3 bits (72), Expect = 0.89
 Identities = 13/39 (33%), Positives = 21/39 (53%), Gaps = 3/39 (7%)

Query: 51  ENEEDGEEDPDRYV---CSGVPGRPPGLEEELTLKYGAK 86
           + +E G   P++++   C G P +PPGL  +    Y AK
Sbjct: 94  KGKESGSSGPNKFILISCGGAPTQPPGLRPQTQTSYDAK 132


>gi|42544167 forkhead box M1 isoform 1 [Homo sapiens]
          Length = 801

 Score = 32.3 bits (72), Expect = 0.89
 Identities = 13/39 (33%), Positives = 21/39 (53%), Gaps = 3/39 (7%)

Query: 51  ENEEDGEEDPDRYV---CSGVPGRPPGLEEELTLKYGAK 86
           + +E G   P++++   C G P +PPGL  +    Y AK
Sbjct: 94  KGKESGSSGPNKFILISCGGAPTQPPGLRPQTQTSYDAK 132


>gi|239755464 PREDICTED: similar to hCG2045708 [Homo sapiens]
          Length = 445

 Score = 32.3 bits (72), Expect = 0.89
 Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 9/64 (14%)

Query: 9   SEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP--DRYVCS 66
           +++EVC E+  L  ++ P PRS       P+ G    + R Q   + G  DP   +    
Sbjct: 94  ADKEVCPEKRKLTESDVPFPRS-------PDHGSPKLEQRLQSCSQRGAGDPYAPKVTSP 146

Query: 67  GVPG 70
           G+PG
Sbjct: 147 GIPG 150


>gi|239749955 PREDICTED: similar to hCG2045708 [Homo sapiens]
          Length = 445

 Score = 32.3 bits (72), Expect = 0.89
 Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 9/64 (14%)

Query: 9   SEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP--DRYVCS 66
           +++EVC E+  L  ++ P PRS       P+ G    + R Q   + G  DP   +    
Sbjct: 94  ADKEVCPEKRKLTESDVPFPRS-------PDHGSPKLEQRLQSCSQRGAGDPYAPKVTSP 146

Query: 67  GVPG 70
           G+PG
Sbjct: 147 GIPG 150


>gi|239744269 PREDICTED: hypothetical protein XP_002343109 [Homo
           sapiens]
          Length = 445

 Score = 32.3 bits (72), Expect = 0.89
 Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 9/64 (14%)

Query: 9   SEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP--DRYVCS 66
           +++EVC E+  L  ++ P PRS       P+ G    + R Q   + G  DP   +    
Sbjct: 94  ADKEVCPEKRKLTESDVPFPRS-------PDHGSPKLEQRLQSCSQRGAGDPYAPKVTSP 146

Query: 67  GVPG 70
           G+PG
Sbjct: 147 GIPG 150


>gi|169212742 PREDICTED: similar to hCG1654128 [Homo sapiens]
          Length = 1015

 Score = 32.0 bits (71), Expect = 1.2
 Identities = 19/54 (35%), Positives = 23/54 (42%), Gaps = 1/54 (1%)

Query: 6   ASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEED 59
           AS +E  +  E      A SPT     +   GPED   T      + EEDG ED
Sbjct: 324 ASPTEHGIDQEEDGPEDA-SPTEHGVDQEEDGPEDASPTEHEHGVDQEEDGPED 376



 Score = 30.0 bits (66), Expect = 4.4
 Identities = 25/79 (31%), Positives = 33/79 (41%), Gaps = 4/79 (5%)

Query: 6   ASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVC 65
           AS +E +V  E      A SPT     +   GPED   T      + +EDG ED  R   
Sbjct: 239 ASPTEHDVGQEEDGPEDA-SPTEHGVDQQEDGPEDASPTE--HGVDQQEDGPEDA-RPTE 294

Query: 66  SGVPGRPPGLEEELTLKYG 84
            GV     G E+    ++G
Sbjct: 295 HGVDQEEDGPEDASLTEHG 313


>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
            sapiens]
          Length = 1998

 Score = 31.6 bits (70), Expect = 1.5
 Identities = 23/112 (20%), Positives = 53/112 (47%), Gaps = 4/112 (3%)

Query: 136  LNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTY 195
            + ++L+ + ++ +++     ++ L   R Y F  GW I   ++++     ++L E+++ Y
Sbjct: 1558 VTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKY 1617

Query: 196  NVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYL 247
             V+   PTL   +     +G +    KG   ++     ++ +L AL  I  L
Sbjct: 1618 FVS---PTLFRVI-RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1665


>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
            [Homo sapiens]
          Length = 2005

 Score = 31.6 bits (70), Expect = 1.5
 Identities = 32/177 (18%), Positives = 71/177 (40%), Gaps = 25/177 (14%)

Query: 71   RPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPS 130
            RP    + +   +  K V  + + + +C+ +V   +                    +T  
Sbjct: 1515 RPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV--------------------ETDD 1554

Query: 131  VGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGE 190
              Q + N +L  + ++ +++     ++ L   R Y F  GW I   ++++     ++L E
Sbjct: 1555 QSQEMTN-ILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAE 1613

Query: 191  VLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYL 247
            +++ Y V+   PTL   +     +G +    KG   ++     ++ +L AL  I  L
Sbjct: 1614 LIEKYFVS---PTLFRVI-RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1666


>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 31.6 bits (70), Expect = 1.5
 Identities = 32/177 (18%), Positives = 71/177 (40%), Gaps = 25/177 (14%)

Query: 71   RPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPS 130
            RP    + +   +  K V  + + + +C+ +V   +                    +T  
Sbjct: 1515 RPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV--------------------ETDD 1554

Query: 131  VGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGE 190
              Q + N +L  + ++ +++     ++ L   R Y F  GW I   ++++     ++L E
Sbjct: 1555 QSQEMTN-ILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAE 1613

Query: 191  VLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYL 247
            +++ Y V+   PTL   +     +G +    KG   ++     ++ +L AL  I  L
Sbjct: 1614 LIEKYFVS---PTLFRVI-RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1666


>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 31.6 bits (70), Expect = 1.5
 Identities = 32/177 (18%), Positives = 71/177 (40%), Gaps = 25/177 (14%)

Query: 71   RPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPS 130
            RP    + +   +  K V  + + + +C+ +V   +                    +T  
Sbjct: 1515 RPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV--------------------ETDD 1554

Query: 131  VGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGE 190
              Q + N +L  + ++ +++     ++ L   R Y F  GW I   ++++     ++L E
Sbjct: 1555 QSQEMTN-ILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAE 1613

Query: 191  VLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYL 247
            +++ Y V+   PTL   +     +G +    KG   ++     ++ +L AL  I  L
Sbjct: 1614 LIEKYFVS---PTLFRVI-RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1666


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.139    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,119,396
Number of Sequences: 37866
Number of extensions: 867783
Number of successful extensions: 3850
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 3705
Number of HSP's gapped (non-prelim): 180
length of query: 448
length of database: 18,247,518
effective HSP length: 106
effective length of query: 342
effective length of database: 14,233,722
effective search space: 4867932924
effective search space used: 4867932924
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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