Search of human proteins with 15529996

Search of human proteins with 15529996

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15529996 son of sevenless homolog 1 [Homo sapiens]
         (1333 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15529996 son of sevenless homolog 1 [Homo sapiens]                2698   0.0  
gi|154689780 son of sevenless homolog 2 [Homo sapiens]               1850   0.0  
gi|224586880 Ras protein-specific guanine nucleotide-releasing f...   151   4e-36
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa...   151   4e-36
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa...   151   4e-36
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa...   147   7e-35
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom...   135   3e-31
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom...   135   3e-31
gi|93102367 ral guanine nucleotide dissociation stimulator-like ...   126   2e-28
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo...   113   1e-24
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ...   113   1e-24
gi|239582765 ral guanine nucleotide dissociation stimulator-like...   105   3e-22
gi|239582763 ral guanine nucleotide dissociation stimulator-like...   103   1e-21
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof...    99   3e-20
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof...    99   3e-20
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]     88   5e-17
gi|23308553 spermatogenesis associated 13 [Homo sapiens]               87   1e-16
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom...    86   3e-16
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa...    85   4e-16
gi|24307909 ral guanine nucleotide dissociation stimulator isofo...    84   7e-16
gi|108796058 ral guanine nucleotide dissociation stimulator isof...    84   7e-16
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi...    82   3e-15
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg...    81   8e-15
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu...    81   8e-15
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [...    80   1e-14
gi|40255197 RasGEF domain family, member 1C [Homo sapiens]             80   1e-14
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul...    80   2e-14
gi|22749129 RasGEF domain family, member 1B [Homo sapiens]             79   3e-14
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...    79   4e-14
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi...    79   4e-14

>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
          Length = 1333

 Score = 2698 bits (6993), Expect = 0.0
 Identities = 1333/1333 (100%), Positives = 1333/1333 (100%)

Query: 1    MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLC 60
            MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLC
Sbjct: 1    MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLC 60

Query: 61   QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGY 120
            QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGY
Sbjct: 61   QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGY 120

Query: 121  KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV 180
            KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
Sbjct: 121  KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV 180

Query: 181  EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSAN 240
            EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSAN
Sbjct: 181  EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSAN 240

Query: 241  DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR 300
            DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR
Sbjct: 241  DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR 300

Query: 301  DILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL 360
            DILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL
Sbjct: 301  DILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL 360

Query: 361  EEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK 420
            EEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK
Sbjct: 361  EEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK 420

Query: 421  KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL 480
            KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL
Sbjct: 421  KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL 480

Query: 481  PGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAA 540
            PGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAA
Sbjct: 481  PGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAA 540

Query: 541  LISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPI 600
            LISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPI
Sbjct: 541  LISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPI 600

Query: 601  IKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR 660
            IKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR
Sbjct: 601  IKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR 660

Query: 661  IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT 720
            IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT
Sbjct: 661  IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT 720

Query: 721  VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH 780
            VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH
Sbjct: 721  VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH 780

Query: 781  PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV 840
            PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV
Sbjct: 781  PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV 840

Query: 841  ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI 900
            ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI
Sbjct: 841  ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI 900

Query: 901  LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK 960
            LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK
Sbjct: 901  LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK 960

Query: 961  RRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN 1020
            RRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN
Sbjct: 961  RRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN 1020

Query: 1021 PKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAP 1080
            PKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAP
Sbjct: 1021 PKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAP 1080

Query: 1081 NSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISL 1140
            NSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISL
Sbjct: 1081 NSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISL 1140

Query: 1141 TKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISD 1200
            TKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISD
Sbjct: 1141 TKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISD 1200

Query: 1201 RTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPP 1260
            RTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPP
Sbjct: 1201 RTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPP 1260

Query: 1261 PQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMH 1320
            PQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMH
Sbjct: 1261 PQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMH 1320

Query: 1321 RDGPPLLENAHSS 1333
            RDGPPLLENAHSS
Sbjct: 1321 RDGPPLLENAHSS 1333


>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
          Length = 1332

 Score = 1850 bits (4791), Expect = 0.0
 Identities = 938/1351 (69%), Positives = 1097/1351 (81%), Gaps = 40/1351 (2%)

Query: 1    MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLC 60
            MQ    PYEFFSEEN+PKWRGLLV AL+KVQ QVHPTL +N+++L Y+EELI QLLN LC
Sbjct: 1    MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLC 60

Query: 61   QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGY 120
             AQPR+  DVEERVQK+FPHPIDKWAIADAQSAIEKRKRRNPL LPV+KIHP LKEVLGY
Sbjct: 61   MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY 120

Query: 121  KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV 180
            K+D+ VS+YIVAVLEYISADILKL GNYV NIRHYEI++QDIKV+MCADKVLMDMF QD 
Sbjct: 121  KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQD- 179

Query: 181  EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSAN 240
             DI ++SL ++EPS+SGE  YYDLV+  +AE RQY+RELN+IIKVFRE F+S+ KLF  +
Sbjct: 180  -DIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPS 238

Query: 241  DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR 300
            D+E IFS I DIHEL+VKLLG IEDTVEMTDE SPHPL GSCFEDLAEE AFDPYE+ ++
Sbjct: 239  DIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQ 298

Query: 301  DILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL 360
            DIL P FH+ F   +++P  AL+ QSI +GFKEAV+YVLPRL+L PVYHC HYFELLKQL
Sbjct: 299  DILSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQL 358

Query: 361  EEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK 420
            +  SE+QED+ECL QAITAL+N+Q  M++I  +   +RR  +  C FYS Q++ K LAIK
Sbjct: 359  KACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIK 418

Query: 421  KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL 480
            KMNEIQKNIDGWEGKDIGQCCNEFIMEG LTR+GAKHERHIFLFDGLMI CK NHGQ RL
Sbjct: 419  KMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRL 478

Query: 481  PGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAA 540
            PG S+AEYRLKEKF MRK+QI DK+DT E+KHAFE++ KDENS+IF+AKSAEEKNNWMAA
Sbjct: 479  PGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAA 538

Query: 541  LISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPI 600
            LISL YRSTL+RMLD  +L+EE E+ +RLPS +VYRF   DSEENI+FE+N+Q ++GIPI
Sbjct: 539  LISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPI 598

Query: 601  IKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR 660
            IK GTV+KLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSL+IERFEIPEPEPT+AD+
Sbjct: 599  IKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADK 658

Query: 661  IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT 720
            +AIE G+QP+SA+LKRFRKEY+QPVQLR+LNV RHWVEHHFYDFERD  LL+R+E FI +
Sbjct: 659  LAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISS 718

Query: 721  VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH 780
            VRGKAMKKWVESI KII+RKK A+ NG  HNITF+S PP +EWHIS+PG  ETFDL+TLH
Sbjct: 719  VRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLH 778

Query: 781  PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV 840
            PIEIARQLTLLESDLYR VQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV
Sbjct: 779  PIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV 838

Query: 841  ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI 900
            E EN EERVAV+SRIIEILQVFQ+LNNFNGVLE+VSA+NS  VYRLDHTFE +  R++KI
Sbjct: 839  EAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKI 898

Query: 901  LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK 960
            L+EA ELS+DH+KKYL KL+SINPPCVPFFGIYLTNILKTEEGN + LK+ GK+LINFSK
Sbjct: 899  LDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSK 958

Query: 961  RRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN 1020
            RRKVAEITGEIQQYQNQPYCLR+E D++RFFENLNPMG++ EKEFTDYLFNKSLEIEPRN
Sbjct: 959  RRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRN 1018

Query: 1021 PKPLPRFPKKYSYPLKSPGVRPSNPR----PGTMR-HPTPLQQEPRKISYSRIPESETES 1075
             K  PRFP+K ++ LKSPG+RP+  R     GT+R HPTPL++EP KIS+SRI E+E ES
Sbjct: 1019 CKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELES 1078

Query: 1076 TASAPNSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASV 1135
            T SAP SP TP TPP     S+++D+    D D +S     ++++F  V LPH  +S   
Sbjct: 1079 TVSAPTSPNTPSTPP----VSASSDLSVFLDVDLNS--SCGSNSIFAPVLLPHS-KSFFS 1131

Query: 1136 SSISLTKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPR 1195
            S  SL K ++E  +PPP+PPR++ +    ++S SK   K  D PPAIPPRQP      PR
Sbjct: 1132 SCGSLHKLSEEPLIPPPLPPRKKFDH---DASNSKGNMKSDDDPPAIPPRQPPPPKVKPR 1188

Query: 1196 YSIS----DRTSISDPPESP----PLLPPREPVRTPDVFSSSPLHLQPPPLG---KKSD- 1243
              +     D    S PP  P    P  PP  P+R P+ F + P +LQPPPLG   + SD 
Sbjct: 1189 VPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDW 1248

Query: 1244 -HGNAFFPNSPSPFTPPPPQTPSPHGTRR-HLPSPPLTQEVDLHSIAGPPVPPRQSTSQH 1301
                +  PNSPS     PP TPSP   RR ++ S   + + +L     PPVPPRQ++S H
Sbjct: 1249 LRDISTCPNSPS----TPPSTPSPRVPRRCYVLS---SSQNNLAHPPAPPVPPRQNSSPH 1301

Query: 1302 IPKLPPKTYKREHTHPSMHRDGPPLLENAHS 1332
            +PKLPPKTYKRE +HP ++R   PLLENA +
Sbjct: 1302 LPKLPPKTYKRELSHPPLYR--LPLLENAET 1330


>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
            1 isoform 3 [Homo sapiens]
          Length = 1257

 Score =  151 bits (382), Expect = 4e-36
 Identities = 102/343 (29%), Positives = 175/343 (51%), Gaps = 32/343 (9%)

Query: 688  RVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAR--- 744
            RVLNV RHWV  H  DFE +  L  ++  F+  V         E +T+  +RK  A    
Sbjct: 937  RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDP-----ELLTQ--ERKAAANIIR 989

Query: 745  ---DNGPGHN-ITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQ 800
                  PG N IT +      E   + P    +        +EIA QLTLL+  +++ + 
Sbjct: 990  TLTQEDPGDNQITLEEITQMAEGVKAEPFENHS-------ALEIAEQLTLLDHLVFKKIP 1042

Query: 801  PSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQ 860
              E  G  W K +K   +P ++K  +H  +++      I+  E++  RV+ + + + +  
Sbjct: 1043 YEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVAD 1102

Query: 861  VFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKKYLAK 918
            + + L+N+N VLE+ S+MN S ++RL  T+ ++  + K ++++  +L  SE  +K     
Sbjct: 1103 ICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREA 1162

Query: 919  LRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQP 978
            L++ +PPCVP+ G+YLT++   EEG P   +     L+NFSK R ++ I  EI+Q+Q   
Sbjct: 1163 LKNCDPPCVPYLGMYLTDLAFIEEGTPNYTE---DGLVNFSKMRMISHIIREIRQFQQTA 1219

Query: 979  YCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNP 1021
            Y +  ++ + ++   L      M++E    L+  SL IEP+ P
Sbjct: 1220 YKIEHQAKVTQY---LLDQSFVMDEE---SLYESSLRIEPKLP 1256



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 44/203 (21%), Positives = 85/203 (41%), Gaps = 15/203 (7%)

Query: 458 ERHIFLFDG-LMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKD--------DTN 508
           ER  FLF   L+IC + + G+  L    N    L +   + + +  +++        D  
Sbjct: 489 ERQCFLFSKHLIICTRGSGGKLHL--TKNGVISLIDCTLLEEPESTEEEAKGSGQDIDHL 546

Query: 509 EYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQMR 568
           ++K   E       +VI  A S +EK  W + +           ++     +  K    +
Sbjct: 547 DFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENSKVTVPQ 606

Query: 569 LPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFL 628
           +  +D   + +   + +I F + M     +  I+  +V +L+ERLT   +   +F+ TFL
Sbjct: 607 MIKSDASLYCD---DVDIRFSKTMN-SCKVLQIRYASVERLLERLTDLRFLSIDFLNTFL 662

Query: 629 TTYRSFCKPQELLSLIIERFEIP 651
            +YR F     +L  +I  ++ P
Sbjct: 663 HSYRVFTTAIVVLDKLITIYKKP 685


>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
            1 isoform 1 [Homo sapiens]
          Length = 1273

 Score =  151 bits (382), Expect = 4e-36
 Identities = 102/343 (29%), Positives = 175/343 (51%), Gaps = 32/343 (9%)

Query: 688  RVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAR--- 744
            RVLNV RHWV  H  DFE +  L  ++  F+  V         E +T+  +RK  A    
Sbjct: 953  RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDP-----ELLTQ--ERKAAANIIR 1005

Query: 745  ---DNGPGHN-ITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQ 800
                  PG N IT +      E   + P    +        +EIA QLTLL+  +++ + 
Sbjct: 1006 TLTQEDPGDNQITLEEITQMAEGVKAEPFENHS-------ALEIAEQLTLLDHLVFKKIP 1058

Query: 801  PSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQ 860
              E  G  W K +K   +P ++K  +H  +++      I+  E++  RV+ + + + +  
Sbjct: 1059 YEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVAD 1118

Query: 861  VFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKKYLAK 918
            + + L+N+N VLE+ S+MN S ++RL  T+ ++  + K ++++  +L  SE  +K     
Sbjct: 1119 ICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREA 1178

Query: 919  LRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQP 978
            L++ +PPCVP+ G+YLT++   EEG P   +     L+NFSK R ++ I  EI+Q+Q   
Sbjct: 1179 LKNCDPPCVPYLGMYLTDLAFIEEGTPNYTE---DGLVNFSKMRMISHIIREIRQFQQTA 1235

Query: 979  YCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNP 1021
            Y +  ++ + ++   L      M++E    L+  SL IEP+ P
Sbjct: 1236 YKIEHQAKVTQY---LLDQSFVMDEE---SLYESSLRIEPKLP 1272



 Score = 34.3 bits (77), Expect = 0.82
 Identities = 50/219 (22%), Positives = 89/219 (40%), Gaps = 34/219 (15%)

Query: 458 ERHIFLFDG-LMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKD--------DTN 508
           ER  FLF   L+IC + + G+  L    N    L +   + + +  +++        D  
Sbjct: 489 ERQCFLFSKHLIICTRGSGGKLHL--TKNGVISLIDCTLLEEPESTEEEAKGSGQDIDHL 546

Query: 509 EYKHAFEIILKDENSVIFSAKSAEEKNNW----------------MAALISLQYRSTLER 552
           ++K   E       +VI  A S +EK  W                M        + T+ +
Sbjct: 547 DFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENSKVTVPQ 606

Query: 553 MLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIER 612
           M+  T  +  +E +M    A +Y       + +I F + M     +  I+  +V +L+ER
Sbjct: 607 MIKRTR-EGTREAEMSRSDASLYC-----DDVDIRFSKTMN-SCKVLQIRYASVERLLER 659

Query: 613 LTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIP 651
           LT   +   +F+ TFL +YR F     +L  +I  ++ P
Sbjct: 660 LTDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKP 698


>gi|24797101 Ras protein-specific guanine nucleotide-releasing factor
            1 isoform 2 [Homo sapiens]
          Length = 489

 Score =  151 bits (382), Expect = 4e-36
 Identities = 102/343 (29%), Positives = 175/343 (51%), Gaps = 32/343 (9%)

Query: 688  RVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAR--- 744
            RVLNV RHWV  H  DFE +  L  ++  F+  V         E +T+  +RK  A    
Sbjct: 169  RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDP-----ELLTQ--ERKAAANIIR 221

Query: 745  ---DNGPGHN-ITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQ 800
                  PG N IT +      E   + P    +        +EIA QLTLL+  +++ + 
Sbjct: 222  TLTQEDPGDNQITLEEITQMAEGVKAEPFENHS-------ALEIAEQLTLLDHLVFKKIP 274

Query: 801  PSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQ 860
              E  G  W K +K   +P ++K  +H  +++      I+  E++  RV+ + + + +  
Sbjct: 275  YEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVAD 334

Query: 861  VFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKKYLAK 918
            + + L+N+N VLE+ S+MN S ++RL  T+ ++  + K ++++  +L  SE  +K     
Sbjct: 335  ICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREA 394

Query: 919  LRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQP 978
            L++ +PPCVP+ G+YLT++   EEG P   +     L+NFSK R ++ I  EI+Q+Q   
Sbjct: 395  LKNCDPPCVPYLGMYLTDLAFIEEGTPNYTE---DGLVNFSKMRMISHIIREIRQFQQTA 451

Query: 979  YCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNP 1021
            Y +  ++ + ++   L      M++E    L+  SL IEP+ P
Sbjct: 452  YKIEHQAKVTQY---LLDQSFVMDEE---SLYESSLRIEPKLP 488


>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
            2 [Homo sapiens]
          Length = 1237

 Score =  147 bits (371), Expect = 7e-35
 Identities = 96/345 (27%), Positives = 172/345 (49%), Gaps = 36/345 (10%)

Query: 688  RVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNG 747
            RVLNV RHWV  H  DFE +  L   +   +  V        +     + Q +K A    
Sbjct: 917  RVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEV--------LRDPDLLPQERKAA---- 964

Query: 748  PGHNITFQSSPPTVEWHISRPGHIETFDLL------TLHPIEIARQLTLLESDLYRAVQP 801
              + +   S     + H+     I+  D +      +L  +E+A Q+TLL+  ++R++  
Sbjct: 965  -ANILRALSQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPY 1023

Query: 802  SELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQV 861
             E +G  W K DK   +P ++K  +H  +++      I+   ++  R   + + + +  +
Sbjct: 1024 EEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADI 1083

Query: 862  FQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKKYLAKL 919
             + L+N+NGVLE+ SA+N S +YRL  T+ ++  + K ++++  +   SE  +K     L
Sbjct: 1084 CRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETL 1143

Query: 920  RSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPY 979
            ++ NPP VP+ G+YLT++   EEG P   +   + L+NFSK R ++ I  EI+Q+Q   Y
Sbjct: 1144 KNCNPPAVPYLGMYLTDLAFIEEGTPNFTE---EGLVNFSKMRMISHIIREIRQFQQTSY 1200

Query: 980  CLRVESDIKRFFENLNPMGNSMEKEF---TDYLFNKSLEIEPRNP 1021
             +  +  + ++          ++K+     D L+  SL+IEPR P
Sbjct: 1201 RIDHQPKVAQYL---------LDKDLIIDEDTLYELSLKIEPRLP 1236



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 47/203 (23%), Positives = 90/203 (44%), Gaps = 14/203 (6%)

Query: 458 ERHIFLFDG-LMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTNE---YKHA 513
           ER  FLF    +IC +S+ G+  L         L +   + +   +D D       + H 
Sbjct: 492 ERQCFLFTKHFLICTRSSGGKLHLLKTGGV-LSLIDCTLIEEPDASDDDSKGSGQVFGHL 550

Query: 514 -FEIILKDENSVIFS----AKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQMR 568
            F+I+++  ++  F+    A S +EK  WM+ +           ++ +   +  K     
Sbjct: 551 DFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPH 610

Query: 569 LPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFL 628
           +  +D  R  + D++  I F + +     +P I+  +V +L+ERLT   +   +F+ TFL
Sbjct: 611 MIKSDA-RLHKDDTD--ICFSKTLN-SCKVPQIRYASVERLLERLTDLRFLSIDFLNTFL 666

Query: 629 TTYRSFCKPQELLSLIIERFEIP 651
            TYR F     +L  + + ++ P
Sbjct: 667 HTYRIFTTAAVVLGKLSDIYKRP 689


>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
            sapiens]
          Length = 1095

 Score =  135 bits (340), Expect = 3e-31
 Identities = 111/403 (27%), Positives = 185/403 (45%), Gaps = 57/403 (14%)

Query: 623  FVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYI 682
            +   FLTTYR+F  P+EL+  +  R+E   P    AD               KR  K   
Sbjct: 733  YCEAFLTTYRTFISPEELIKKLQYRYEKFSPF---ADTFK------------KRVSKNTF 777

Query: 683  QPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKI 742
              +   V  +C   +            L++ +   +        +   ++I   + +KK+
Sbjct: 778  FVLVRVVDELCLVELTEEILKL-----LMELVFRLVCNGELSLARVLRKNILDKVDQKKL 832

Query: 743  ARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPS 802
             R           S P       +RPG +  F     H  EIA QLTLL+++L+  ++  
Sbjct: 833  LR-------CATSSQPLAARGVAARPGTLHDF-----HSHEIAEQLTLLDAELFYKIEIP 880

Query: 803  ELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVF 862
            E++  +W KE  E  SPNL +   H  N++ W    I+  E  ++R  ++ + I+I++  
Sbjct: 881  EVL--LWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHL 938

Query: 863  QELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL-----SEDHYKKYLA 917
            ++LNNFN  L ++SA++S+P+ RL+         QK+  E   E      S   ++ Y A
Sbjct: 939  RKLNNFNSYLAILSALDSAPIRRLEW--------QKQTSEGLAEYCTLIDSSSSFRAYRA 990

Query: 918  KLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQ 977
             L  + PPC+P+ G+ L ++     GNP+ +   GK  +NFSKR +   I   ++ +Q  
Sbjct: 991  ALSEVEPPCIPYLGLILQDLTFVHLGNPDYI--DGK--VNFSKRWQQFNILDSMRCFQQA 1046

Query: 978  PYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN 1020
             Y +R   DI  FF   N   + + +E    L+  SL+I+PRN
Sbjct: 1047 HYDMRRNDDIINFF---NDFSDHLAEE---ALWELSLKIKPRN 1083



 Score = 34.7 bits (78), Expect = 0.63
 Identities = 58/272 (21%), Positives = 98/272 (36%), Gaps = 57/272 (20%)

Query: 993  NLNPMGNSMEKEFTDYL---FNKSLEIEPRNPKPL---------PRFPKKYSYPLKSPGV 1040
            NL+P+  S+ +  + +L   F   L   P+   PL         P  P+K      S   
Sbjct: 428  NLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRSAASQTA 487

Query: 1041 RPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAPNSPRTP---LTPPPASGASS 1097
              S  R    RHP+          Y  I   + +STA  P+ P  P   + P    G+S+
Sbjct: 488  DGSGCRVSYERHPS---------QYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSA 538

Query: 1098 TTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISLTKGTDEVPVPPPVPPRR 1157
              +    F  D ++P  S+ D        P  P   +   ++  +  ++   P P    +
Sbjct: 539  PVE----FVGDFTAP-ESTGDPE----KPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQ 589

Query: 1158 RPESAPAESSPSKIMSK---------------HLDSPPAIPPRQ-----PTSKAYSPRYS 1197
             P++       +K++ +                L  PPA+PP+Q     P  K   PR  
Sbjct: 590  TPQNEHIYQQKNKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLEPPAGKDGHPR-- 647

Query: 1198 ISDRTSISDPPESPPLLPPREPVRTPDVFSSS 1229
              D +++S  P            ++PD   S+
Sbjct: 648  --DPSAVSGVPGKDSRDGSERAPKSPDALESA 677


>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
            sapiens]
          Length = 1077

 Score =  135 bits (340), Expect = 3e-31
 Identities = 111/403 (27%), Positives = 185/403 (45%), Gaps = 57/403 (14%)

Query: 623  FVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYI 682
            +   FLTTYR+F  P+EL+  +  R+E   P    AD               KR  K   
Sbjct: 715  YCEAFLTTYRTFISPEELIKKLQYRYEKFSPF---ADTFK------------KRVSKNTF 759

Query: 683  QPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKI 742
              +   V  +C   +            L++ +   +        +   ++I   + +KK+
Sbjct: 760  FVLVRVVDELCLVELTEEILKL-----LMELVFRLVCNGELSLARVLRKNILDKVDQKKL 814

Query: 743  ARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPS 802
             R           S P       +RPG +  F     H  EIA QLTLL+++L+  ++  
Sbjct: 815  LR-------CATSSQPLAARGVAARPGTLHDF-----HSHEIAEQLTLLDAELFYKIEIP 862

Query: 803  ELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVF 862
            E++  +W KE  E  SPNL +   H  N++ W    I+  E  ++R  ++ + I+I++  
Sbjct: 863  EVL--LWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHL 920

Query: 863  QELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL-----SEDHYKKYLA 917
            ++LNNFN  L ++SA++S+P+ RL+         QK+  E   E      S   ++ Y A
Sbjct: 921  RKLNNFNSYLAILSALDSAPIRRLEW--------QKQTSEGLAEYCTLIDSSSSFRAYRA 972

Query: 918  KLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQ 977
             L  + PPC+P+ G+ L ++     GNP+ +   GK  +NFSKR +   I   ++ +Q  
Sbjct: 973  ALSEVEPPCIPYLGLILQDLTFVHLGNPDYI--DGK--VNFSKRWQQFNILDSMRCFQQA 1028

Query: 978  PYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN 1020
             Y +R   DI  FF   N   + + +E    L+  SL+I+PRN
Sbjct: 1029 HYDMRRNDDIINFF---NDFSDHLAEE---ALWELSLKIKPRN 1065



 Score = 34.7 bits (78), Expect = 0.63
 Identities = 58/272 (21%), Positives = 98/272 (36%), Gaps = 57/272 (20%)

Query: 993  NLNPMGNSMEKEFTDYL---FNKSLEIEPRNPKPL---------PRFPKKYSYPLKSPGV 1040
            NL+P+  S+ +  + +L   F   L   P+   PL         P  P+K      S   
Sbjct: 410  NLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRSAASQTA 469

Query: 1041 RPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAPNSPRTP---LTPPPASGASS 1097
              S  R    RHP+          Y  I   + +STA  P+ P  P   + P    G+S+
Sbjct: 470  DGSGCRVSYERHPS---------QYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSA 520

Query: 1098 TTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISLTKGTDEVPVPPPVPPRR 1157
              +    F  D ++P  S+ D        P  P   +   ++  +  ++   P P    +
Sbjct: 521  PVE----FVGDFTAP-ESTGDPE----KPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQ 571

Query: 1158 RPESAPAESSPSKIMSK---------------HLDSPPAIPPRQ-----PTSKAYSPRYS 1197
             P++       +K++ +                L  PPA+PP+Q     P  K   PR  
Sbjct: 572  TPQNEHIYQQKNKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLEPPAGKDGHPR-- 629

Query: 1198 ISDRTSISDPPESPPLLPPREPVRTPDVFSSS 1229
              D +++S  P            ++PD   S+
Sbjct: 630  --DPSAVSGVPGKDSRDGSERAPKSPDALESA 659


>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
            [Homo sapiens]
          Length = 803

 Score =  126 bits (316), Expect = 2e-28
 Identities = 145/621 (23%), Positives = 260/621 (41%), Gaps = 110/621 (17%)

Query: 598  IPIIKAGTVIKLIERL-TYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERF-EIPEPEP 655
            I  IKAGT+ KL+E L T     D  ++  FL+TYR F   +E+L L+++R+  +  P  
Sbjct: 101  IRTIKAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPN- 159

Query: 656  TEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYL--LQR 713
                    E+G Q  S        E    ++  + ++ R W++    DF    +   LQ+
Sbjct: 160  ------CEEDGSQSSS--------ESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQK 205

Query: 714  MEEFIGTVR-GKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIE 772
            + +++  +  G   ++  +++ +  Q++++  DNG  + I+F     ++E      G  E
Sbjct: 206  LLDYLTRMMPGSDPERRAQNLLEQFQKQEVETDNGLPNTISF-----SLEEEEELEGG-E 259

Query: 773  TFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLT 832
            + +        +A QLT +++ L++ V P   +G +W++ DK+ N  +L   IR T +  
Sbjct: 260  SAEFTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENK-HLAPTIRATISQF 318

Query: 833  LWFEKCIVETE------NLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRL 886
                KC+V T         ++R  ++ + I I    + L NF+ +  +VSA+ S+ +YRL
Sbjct: 319  NTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRL 378

Query: 887  DHTFEQIPSRQKKILEEAHELSEDH---------------------------------YK 913
              T+  +P  +  + EE  ++  DH                                  +
Sbjct: 379  KKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRR 438

Query: 914  KYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQ 973
              L K   +    VP+ G +LT++   +    + ++     LINF KRR+  E+  +I+ 
Sbjct: 439  LQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIE---GGLINFEKRRREFEVIAQIKL 495

Query: 974  YQN--QPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKY 1031
             Q+    YC+  +    ++F+    +    E          + +    +PKP     K+ 
Sbjct: 496  LQSACNSYCMTPDQKFIQWFQR-QQLLTEEESYALSCEIEAAADASTTSPKPRKSMVKRL 554

Query: 1032 SYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKI-------SYSRIPESETESTAS-APNSP 1083
            S       +  S         PTP +++P+         S   +  S  ES  S A    
Sbjct: 555  SLLFLGSDMITS---------PTPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAEEGS 605

Query: 1084 RTPLTPP--PASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQ-VTLPHG--------PRS 1132
             TP+  P  P    S ++  CS   S HS   +SS  +  I  ++ P           RS
Sbjct: 606  ITPMDTPDEPQKKLSESSSSCS---SIHSMDTNSSGMSSLINPLSSPPSCNNNPKIHKRS 662

Query: 1133 ASVSSISLTKGTDEVPVPPPV 1153
             SV+SI+ T       V PPV
Sbjct: 663  VSVTSITST-------VLPPV 676


>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
            sapiens]
          Length = 583

 Score =  113 bits (282), Expect = 1e-24
 Identities = 70/256 (27%), Positives = 132/256 (51%), Gaps = 13/256 (5%)

Query: 774  FDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTL 833
            FD+L + P E A Q+TL++  +++A+QP EL    W K++K  ++PN +   R   +++ 
Sbjct: 43   FDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSF 102

Query: 834  WFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQI 893
            W  + I+  + L+ R  V+S  I+  +   ELNN + ++ VVS + S+P++RL  T+  +
Sbjct: 103  WVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALL 162

Query: 894  PSRQKKILEEAHEL--SEDHYKK---YLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVL 948
              + K   E+   +   ED+YK+   Y++ L+    PC+P+ GIYL+++   +   P   
Sbjct: 163  SRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKM--TPCIPYLGIYLSDLTYIDSAYPST- 219

Query: 949  KRHGKELINFSKRRKVAEITGEIQQYQNQ-PYCLRVESDIKRFFENLNPMGNSMEKEFTD 1007
               G  L N  +   +  I   I   Q    Y + +   ++++  ++  +   ++K   D
Sbjct: 220  ---GSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYI-EELQKFVED 275

Query: 1008 YLFNKSLEIEPRNPKP 1023
              +  SL+IEP    P
Sbjct: 276  DNYKLSLKIEPGTSTP 291


>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
            sapiens]
          Length = 557

 Score =  113 bits (282), Expect = 1e-24
 Identities = 71/261 (27%), Positives = 134/261 (51%), Gaps = 22/261 (8%)

Query: 774  FDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTL 833
            FD+L + P E A Q+TL++  +++A+QP EL    W+K++K   +PN++   R    ++ 
Sbjct: 44   FDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSF 103

Query: 834  WFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQI 893
            W  + I+  + L+ R  ++S  ++I +   ELNN + ++ VVSA+ S+P++RL  T+  +
Sbjct: 104  WVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALL 163

Query: 894  PSRQKKILEEAHEL--SEDHYKKYLAKLRSIN-PPCVPFFGIYLTNILKTEEGNP---EV 947
              + K   E+   L   ED+YK+    +RS+   P +P+ GIYL +++  +   P    +
Sbjct: 164  NRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSI 223

Query: 948  LKRHGKELINFSKRRKVAEITGEIQ---QYQNQPYCLRVESDIK--RFFENLNPMGNSME 1002
            ++   +     ++   +  I  ++Q    Y +      V+  +K  R+ E L       +
Sbjct: 224  MENEQRS----NQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEEL-------Q 272

Query: 1003 KEFTDYLFNKSLEIEPRNPKP 1023
            K   D  +  SL IEP +  P
Sbjct: 273  KFVEDDNYKLSLRIEPGSSSP 293


>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
            isoform 1 [Homo sapiens]
          Length = 716

 Score =  105 bits (262), Expect = 3e-22
 Identities = 142/598 (23%), Positives = 233/598 (38%), Gaps = 106/598 (17%)

Query: 598  IPIIKAGTVIKLIERLTY-HMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPT 656
            + +++A  + +L+  L +     DP+F+  FL TYR+F     LL  ++     P P   
Sbjct: 66   VRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPPPPPGV 125

Query: 657  EADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYL---LQR 713
            E  + A++  D   +  L+             V++V   W++ H  DF RD      L  
Sbjct: 126  EIKKTAVQ--DLSFNKNLRA------------VVSVLGSWLQDHPQDF-RDPPAHSDLGS 170

Query: 714  MEEFIG-TVRGKAMKKWVESITK-IIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHI 771
            +  F+G    G A  +  E + +  ++  +  ++  P    T    PP V    S P   
Sbjct: 171  VRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQEEEPPQVWT---GPPRVA-QTSDPDSS 226

Query: 772  ETF------------DLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDK---EI 816
            E               LL     E+A QLTL++ +L+  V+  E +GSVW++ D+     
Sbjct: 227  EACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAG 286

Query: 817  NSPNLLKMIRHTTNLTLWFEKCIVETENL--EERVAVVSRIIEILQVFQELNNFNGVLEV 874
             SP +   +     +T      ++    L   +R   + + I I Q  +EL NF+ +  +
Sbjct: 287  ASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAI 346

Query: 875  VSAMNSSPVYRLDHTF----------------------EQIPSRQKKILEEAHELSEDHY 912
            +SA+ S+P+YRL  ++                        + SR+    EEA E S++  
Sbjct: 347  LSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEE- 405

Query: 913  KKYLAKLRSINPP-CVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEI 971
                  L S  PP  VP+ G +LT+++  +   P++L+    +LINF KRRK  EI   I
Sbjct: 406  DNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLE---GDLINFEKRRKEWEILARI 462

Query: 972  QQYQN--QPYCLRVESDIKRFFENLNPMGNSMEKEFTDYL------------FNKSLEIE 1017
            QQ Q   Q Y L     I       N +        +  +              + + + 
Sbjct: 463  QQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLT 522

Query: 1018 PRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTA 1077
             R    L R  +K S P  SPG  PS+P       P+     P     SR   + +   +
Sbjct: 523  KRLSAKLAR--EKSSSPSGSPG-DPSSPTSSLCISPSVSPGSPPSSPRSRDAPAGSPPAS 579

Query: 1078 SAPNSPRT--------------------PLTPPPASGASSTTDVCSVFDSDHSSPFHS 1115
              P  P T                    P  P PA  +S    +    D+DH + + S
Sbjct: 580  PGPQGPSTKLPLSLDLPSPRPFALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLYRS 637



 Score = 31.6 bits (70), Expect = 5.3
 Identities = 56/252 (22%), Positives = 87/252 (34%), Gaps = 49/252 (19%)

Query: 1070 ESETESTASAPNSPRT-PLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPH 1128
            E  TE +    N+P + P  PPP       T +  +   D + P     D +  +     
Sbjct: 396  EEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKE 455

Query: 1129 GPRSASVSSISLTKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPT 1188
                A +  +     +  +   PP+      ++   E    ++ S+ ++ P A  P  P 
Sbjct: 456  WEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYRL-SRVIEPPAASCPSSPR 514

Query: 1189 SKAYSPRYSISDRTSI-------SDPPESP--PLLPPREPVRTPDVFSSSPLHLQPPPLG 1239
             +    R S++ R S        S P  SP  P  P      +P V   SP         
Sbjct: 515  IRR---RISLTKRLSAKLAREKSSSPSGSPGDPSSPTSSLCISPSVSPGSP--------- 562

Query: 1240 KKSDHGNAFFPNSPSPFTPP---PPQTPSPHGTRRHLPSPPLTQEVDLHS-------IAG 1289
                      P+SP     P   PP +P P G     PS  L   +DL S       +  
Sbjct: 563  ----------PSSPRSRDAPAGSPPASPGPQG-----PSTKLPLSLDLPSPRPFALPLGS 607

Query: 1290 PPVP-PRQSTSQ 1300
            P +P P Q +S+
Sbjct: 608  PRIPLPAQQSSE 619


>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
            isoform 2 [Homo sapiens]
          Length = 710

 Score =  103 bits (257), Expect = 1e-21
 Identities = 146/593 (24%), Positives = 233/593 (39%), Gaps = 102/593 (17%)

Query: 598  IPIIKAGTVIKLIERLTY-HMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPT 656
            + +++A  + +L+  L +     DP+F+  FL TYR+F     LL  ++     P P   
Sbjct: 66   VRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPPPPPGV 125

Query: 657  EADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYL---LQR 713
            E  + A++  D   +  L+             V++V   W++ H  DF RD      L  
Sbjct: 126  EIKKTAVQ--DLSFNKNLRA------------VVSVLGSWLQDHPQDF-RDPPAHSDLGS 170

Query: 714  MEEFIG-TVRGKAMKKWVESITK-IIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHI 771
            +  F+G    G A  +  E + +  ++  +  ++  P    T    PP V    S P   
Sbjct: 171  VRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQEEEPPQVWT---GPPRVA-QTSDPDSS 226

Query: 772  ETF------------DLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDK---EI 816
            E               LL     E+A QLTL++ +L+  V+  E +GSVW++ D+     
Sbjct: 227  EACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAG 286

Query: 817  NSPNLLKMIRHTTNLTLWFEKCIVETENL--EERVAVVSRIIEILQVFQELNNFNGVLEV 874
             SP +   +     +T      ++    L   +R   + + I I Q  +EL NF+ +  +
Sbjct: 287  ASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAI 346

Query: 875  VSAMNSSPVYRLDHTF----------------------EQIPSRQKKILEEAHELSEDHY 912
            +SA+ S+P+YRL  ++                        + SR+    EEA E S++  
Sbjct: 347  LSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEE- 405

Query: 913  KKYLAKLRSINPP-CVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEI 971
                  L S  PP  VP+ G +LT+++  +   P++L+    +LINF KRRK  EI   I
Sbjct: 406  DNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLE---GDLINFEKRRKEWEILARI 462

Query: 972  QQYQN--QPYCLR---------------VESDIKRFFENLNPMGNSMEK--------EFT 1006
            QQ Q   Q Y L                 E    R    + P   S             T
Sbjct: 463  QQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLT 522

Query: 1007 DYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR----PGTMRHPTPLQQEPRK 1062
              L  K    +  +P   P  P   +  + SPG  PS+PR    P      +P  Q P  
Sbjct: 523  KRLSAKLAREKSSSPSGSPGDPSSPTSSV-SPGSPPSSPRSRDAPAGSPPASPGPQGPST 581

Query: 1063 ISYSRIPESETESTASAPNSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHS 1115
                 +        A    SPR PL   PA  +S    +    D+DH + + S
Sbjct: 582  KLPLSLDLPSPRPFALPLGSPRIPL---PAQQSSEARVIRVSIDNDHGNLYRS 631


>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform b
            [Homo sapiens]
          Length = 867

 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 69/276 (25%), Positives = 126/276 (45%), Gaps = 20/276 (7%)

Query: 754  FQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKED 813
            F S  P  E      G + TF+L++    ++A Q+T+ + +L+  V   EL+   + + +
Sbjct: 604  FDSLTPLPEQEGPTVGTVGTFELMSSK--DLAYQMTIYDWELFNCVHELELIYHTFGRHN 661

Query: 814  KEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLE 873
             +  + NL   +R    +  W    I     L +RV ++ + I+I    +E  N N    
Sbjct: 662  FKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 721

Query: 874  VVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSED--HYKKYLAKLRSINPPCVPFFG 931
            +V  +++  V RL  T+E++PS+ KK   E   L +   +++ Y   +  + PP +PF  
Sbjct: 722  IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMP 781

Query: 932  IYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPY------CLRVES 985
            + + ++  T EGN    K     L+NF K R +A     ++ Y++QP+        +   
Sbjct: 782  LLIKDMTFTHEGN----KTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQ 837

Query: 986  DIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNP 1021
            D++ +   LN + N         L   S  +EPR P
Sbjct: 838  DVRSYVRQLNVIDNQRT------LSQMSHRLEPRRP 867


>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform a
            [Homo sapiens]
          Length = 1011

 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 69/276 (25%), Positives = 126/276 (45%), Gaps = 20/276 (7%)

Query: 754  FQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKED 813
            F S  P  E      G + TF+L++    ++A Q+T+ + +L+  V   EL+   + + +
Sbjct: 748  FDSLTPLPEQEGPTVGTVGTFELMSSK--DLAYQMTIYDWELFNCVHELELIYHTFGRHN 805

Query: 814  KEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLE 873
             +  + NL   +R    +  W    I     L +RV ++ + I+I    +E  N N    
Sbjct: 806  FKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 865

Query: 874  VVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSED--HYKKYLAKLRSINPPCVPFFG 931
            +V  +++  V RL  T+E++PS+ KK   E   L +   +++ Y   +  + PP +PF  
Sbjct: 866  IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMP 925

Query: 932  IYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPY------CLRVES 985
            + + ++  T EGN    K     L+NF K R +A     ++ Y++QP+        +   
Sbjct: 926  LLIKDMTFTHEGN----KTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQ 981

Query: 986  DIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNP 1021
            D++ +   LN + N         L   S  +EPR P
Sbjct: 982  DVRSYVRQLNVIDNQRT------LSQMSHRLEPRRP 1011


>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
          Length = 1499

 Score = 88.2 bits (217), Expect = 5e-17
 Identities = 54/195 (27%), Positives = 100/195 (51%), Gaps = 9/195 (4%)

Query: 776 LLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWF 835
           LL L  +E+A QL++   +L+R ++P+E +  ++    K  +  NL +        T W 
Sbjct: 713 LLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKT-SCANLKRFEEVINQETFWV 771

Query: 836 EKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPS 895
              I+   N  +R+ ++   I+I    +E  NFN +  ++S +N +PV RL  T+E++P+
Sbjct: 772 ASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPN 831

Query: 896 RQKKILEEAHELSED--HYKKYLAKLRSIN--PPCVPFFGIYLTNILKTEEGNPEVLKRH 951
           + +K+ ++  +L +   +  KY   L S N  PP +P F +   ++    EGN   +   
Sbjct: 832 KYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--- 888

Query: 952 GKELINFSKRRKVAE 966
              L+NF K R +A+
Sbjct: 889 -DGLVNFEKLRMIAK 902



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 33/122 (27%), Positives = 48/122 (39%), Gaps = 38/122 (31%)

Query: 611 ERLTYHMY-----ADPNFVRTFLTTYRSF-CKPQELLSLIIERFEIPEPEPTEADRIAIE 664
           ERLT H+       DP F+  FL TYR+F   P E+   ++E F  P             
Sbjct: 277 ERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS------------ 324

Query: 665 NGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGK 724
                               ++ +V  V   WV +HF DFE D  + + +EEF   +  +
Sbjct: 325 --------------------LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLERE 364

Query: 725 AM 726
            M
Sbjct: 365 KM 366


>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
          Length = 652

 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 98/397 (24%), Positives = 170/397 (42%), Gaps = 56/397 (14%)

Query: 190 DEEPSTSG-------EQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDV 242
           DEE S S        +Q   ++++  M   R YI+ L  I + +      ++ +F+   +
Sbjct: 223 DEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQL 282

Query: 243 ENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPH-PLVGSCFEDLAEELAFDPYESYARD 301
             IF  I DI++   K L  +E   +  ++  PH   +GSCF  L  +  F  Y  Y  +
Sbjct: 283 ATIFGNIEDIYKFQRKFLKDLE---KQYNKEEPHLSEIGSCF--LQNQEGFAIYSEYCNN 337

Query: 302 ILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYH-CLHYFELLKQL 360
              PG     L+ L K G   +        ++ +   +   LL PV   C +  +L + L
Sbjct: 338 --HPGACLE-LANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELL 394

Query: 361 EEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK 420
           +  +++  D   +K A  A+ NV       C  +  KR+L                 +I 
Sbjct: 395 KYTTQEHGDYSNIKAAYEAMKNVA------CLINERKRKLE----------------SID 432

Query: 421 KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRV---GAKHERHIFLFDGLMICCKSNHGQ 477
           K+   Q +I GWEG DI    +E I  G LT++   G   +R  FLFD  ++ CK +   
Sbjct: 433 KIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKD--- 489

Query: 478 PRLPGASNAEYRLKEKFFMRKVQI------NDKDDTNEYKHAFEIILKDENSV-IFSAKS 530
             L       Y  K +  M ++++       DKD     K+AF+++ +  + V +F AK 
Sbjct: 490 --LLRRDMLYY--KGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKK 545

Query: 531 AEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQM 567
            E+K  W+ A    + R   ++ + + + + +K+  M
Sbjct: 546 QEDKARWLQACADERRRVQEDKEMGMEISENQKKLAM 582


>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
            sapiens]
          Length = 730

 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 57/249 (22%), Positives = 116/249 (46%), Gaps = 15/249 (6%)

Query: 776  LLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWF 835
            +L ++  ++A +L   +  L+ ++   EL+   ++++    ++ NL  +++    + LW 
Sbjct: 491  ILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWV 550

Query: 836  EKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPS 895
               I+    L +RV +V + I+I    +   N N    +V  +N++ V RL  T+E+IP 
Sbjct: 551  ATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPG 610

Query: 896  RQKKILEEAHELSED--HYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGK 953
            + KK+  E   L++   ++K Y    + + PP +PF  + L ++    EGN   L     
Sbjct: 611  KFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFL----D 666

Query: 954  ELINFSKRRKVAEITGEIQQYQNQPY---CLRVESDIKRFFENLNPMGNSMEKEFTDYLF 1010
             L+NF K   +A+    ++  +   +     +   ++K +  +L  + +         LF
Sbjct: 667  NLVNFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQA------LF 720

Query: 1011 NKSLEIEPR 1019
              S  IEPR
Sbjct: 721  ELSHRIEPR 729


>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
            I [Homo sapiens]
          Length = 1601

 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 57/203 (28%), Positives = 106/203 (52%), Gaps = 14/203 (6%)

Query: 776  LLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNL-TLW 834
            +L L  IE+A QL++ + DL+R ++P+E +  ++    K  N+   LK      N  T W
Sbjct: 856  MLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTH--LKRFEDIVNQETFW 913

Query: 835  FEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIP 894
                I+   N  +R+ ++   I+I    +E  NFN +  ++S +N + V RL  T+E++P
Sbjct: 914  VASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLP 973

Query: 895  SRQKKILEEAHELSED--HYKKY--LAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKR 950
            S+ +K L++  ++ +   +  KY  +   +S+ PP +P F +   ++    EGN   +  
Sbjct: 974  SKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKV-- 1031

Query: 951  HGKELINFSKRRKVAEITGEIQQ 973
                L+NF K R +++   EI+Q
Sbjct: 1032 --DGLVNFEKLRMISK---EIRQ 1049



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 29/123 (23%), Positives = 47/123 (38%), Gaps = 31/123 (25%)

Query: 595 KAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPE 654
           + G  +IKA     ++  +  H   DP ++  FL TYR+F                    
Sbjct: 411 RKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFL------------------- 451

Query: 655 PTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRM 714
                       + PL   +K      I  ++ +V  +   WV +HF DFE D  + + +
Sbjct: 452 ------------ESPLDVGIKLLEWFKIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFL 499

Query: 715 EEF 717
           EEF
Sbjct: 500 EEF 502


>gi|24307909 ral guanine nucleotide dissociation stimulator isoform 1
            [Homo sapiens]
          Length = 914

 Score = 84.3 bits (207), Expect = 7e-16
 Identities = 68/275 (24%), Positives = 123/275 (44%), Gaps = 41/275 (14%)

Query: 776  LLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWF 835
            LL   P  +A Q TL++++L++ V P   +GS+W++ DK+    +L   IR T       
Sbjct: 382  LLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKK-GKEHLAPTIRATVTQFNSV 440

Query: 836  EKCIVET------ENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHT 889
              C++ T          +R  VV   IE+ +  + L NF+ +  ++SA+ S+ ++RL  T
Sbjct: 441  ANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKT 500

Query: 890  FEQIPSRQKKILEEAHELSEDHYKKYLAK------------LRSINPP------------ 925
            +E +     +I ++  E+  D     L++               +NP             
Sbjct: 501  WEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGII 560

Query: 926  --CVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRV 983
               VP+ G +LT+++  +    + L  +G+ LINF KRRK  E+  +I+  Q+      +
Sbjct: 561  QGTVPYLGTFLTDLVMLDTAMKDYL--YGR-LINFEKRRKEFEVIAQIKLLQSACNNYSI 617

Query: 984  ESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEP 1018
              D     E       ++E+      +N S E+EP
Sbjct: 618  APD-----EQFGAWFRAVERLSETESYNLSCELEP 647



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 35/139 (25%), Positives = 63/139 (45%), Gaps = 18/139 (12%)

Query: 591 NMQPKAGIPIIKAGTVIKLIERLTYHMY-ADPNFVRTFLTTYRSFCKPQELLSLIIERFE 649
           N+     +  +KAGT+ KL+E L      +D ++V  FL TYR+F   Q++L L+ +R+ 
Sbjct: 106 NLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYG 165

Query: 650 --------------IPEPEPTEADRIAIENG-DQPLSAELKRFRKEYIQPVQLRVLNVCR 694
                         +P  +     +  ++N     L   L ++ +++ QP     L    
Sbjct: 166 RCDALTASSRYGCILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLV 225

Query: 695 HWVEHHF--YDFERDAYLL 711
            +V+ +    D ER A+LL
Sbjct: 226 AYVQLNMPGSDLERRAHLL 244


>gi|108796058 ral guanine nucleotide dissociation stimulator isoform 2
            [Homo sapiens]
          Length = 859

 Score = 84.3 bits (207), Expect = 7e-16
 Identities = 68/275 (24%), Positives = 123/275 (44%), Gaps = 41/275 (14%)

Query: 776  LLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWF 835
            LL   P  +A Q TL++++L++ V P   +GS+W++ DK+    +L   IR T       
Sbjct: 327  LLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKK-GKEHLAPTIRATVTQFNSV 385

Query: 836  EKCIVET------ENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHT 889
              C++ T          +R  VV   IE+ +  + L NF+ +  ++SA+ S+ ++RL  T
Sbjct: 386  ANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKT 445

Query: 890  FEQIPSRQKKILEEAHELSEDHYKKYLAK------------LRSINPP------------ 925
            +E +     +I ++  E+  D     L++               +NP             
Sbjct: 446  WEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGII 505

Query: 926  --CVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRV 983
               VP+ G +LT+++  +    + L  +G+ LINF KRRK  E+  +I+  Q+      +
Sbjct: 506  QGTVPYLGTFLTDLVMLDTAMKDYL--YGR-LINFEKRRKEFEVIAQIKLLQSACNNYSI 562

Query: 984  ESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEP 1018
              D     E       ++E+      +N S E+EP
Sbjct: 563  APD-----EQFGAWFRAVERLSETESYNLSCELEP 592



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 35/139 (25%), Positives = 63/139 (45%), Gaps = 18/139 (12%)

Query: 591 NMQPKAGIPIIKAGTVIKLIERLTYHMY-ADPNFVRTFLTTYRSFCKPQELLSLIIERFE 649
           N+     +  +KAGT+ KL+E L      +D ++V  FL TYR+F   Q++L L+ +R+ 
Sbjct: 51  NLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYG 110

Query: 650 --------------IPEPEPTEADRIAIENG-DQPLSAELKRFRKEYIQPVQLRVLNVCR 694
                         +P  +     +  ++N     L   L ++ +++ QP     L    
Sbjct: 111 RCDALTASSRYGCILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLV 170

Query: 695 HWVEHHF--YDFERDAYLL 711
            +V+ +    D ER A+LL
Sbjct: 171 AYVQLNMPGSDLERRAHLL 189


>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapiens]
          Length = 797

 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 90/370 (24%), Positives = 157/370 (42%), Gaps = 31/370 (8%)

Query: 687  LRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKI-ARD 745
            L++    R+W+   +  F+ DA L   MEEF   V+ K      E   ++I   +I ARD
Sbjct: 123  LKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGE----ELHCRLIDTTQINARD 178

Query: 746  NGPGHNITFQSSPPTVEWHISRPGHIET-FDLLTLHPIEIARQLTLLESDLYRAVQPSEL 804
                     +     ++ + S+   +   FD   L P E++  LT LE   +R +  S+ 
Sbjct: 179  WS-------RKLTQRIKSNTSKKRKVSLLFD--HLEPEELSEHLTYLEFKSFRRISFSDY 229

Query: 805  VGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQE 864
               +     KE  +P + + I     ++ W +  ++     + R  V  + I++ Q   +
Sbjct: 230  QNYLVNSCVKE--NPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQ 287

Query: 865  LNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKKYLAKLRSI 922
            L NFN ++ V+  +  S + RL  T   +P    K+L E  EL  S  +Y  Y       
Sbjct: 288  LQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGEC 347

Query: 923  NPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLR 982
                +P  G++L +++   E  P+ L+  GK  +N  K   +     E+ Q Q     L 
Sbjct: 348  TDFKIPILGVHLKDLISLYEAMPDYLE-DGK--VNVHKLLALYNHISELVQLQEVAPPLE 404

Query: 983  VESDIKRFFENLNPMGNSMEKEFT-DYLFNKSLEIEPRNPKPLPRFPKKYSYPLK-SPGV 1040
               D+      ++ +  S++  +T D ++  S   EPRN +  P  P K    +  + GV
Sbjct: 405  ANKDL------VHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGV 458

Query: 1041 RPSNPRPGTM 1050
             P  P P T+
Sbjct: 459  SP-KPDPKTI 467


>gi|213385270 RAS guanyl releasing protein 3 (calcium and
            DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 88/382 (23%), Positives = 153/382 (40%), Gaps = 50/382 (13%)

Query: 686  QLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARD 745
            +L++    R+W+     +F  D  L++  EEF         +K V  I            
Sbjct: 71   RLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI---------- 120

Query: 746  NGPGHNITFQSSPPTVEW--------HISRPGHI-ETFDLLTLHPIEIARQLTLLESDLY 796
                      SS P+ +W         +S+ G     FD   L PIE+A  LT LE   +
Sbjct: 121  ----------SSIPSYDWMRRVTQRKKVSKKGKACLLFD--HLEPIELAEHLTFLEHKSF 168

Query: 797  RAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRII 856
            R +  ++    V        N+P L + I     ++ W +  ++     ++R  V+++ I
Sbjct: 169  RRISFTDYQSYVI--HGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFI 226

Query: 857  EILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKK 914
             + +   +L NFN ++ VV  ++ S + RL  T   + S   K   E  EL  S  +Y  
Sbjct: 227  NVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCN 286

Query: 915  YLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQY 974
            Y       +   +P  G++L +++      P+  +   +  +N  K  +++    E+   
Sbjct: 287  YRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTE---ENKVNIVKMHQLSVTLSELVSL 343

Query: 975  QNQPYCLRVESDIKRFFENLNPMGNSMEKEFT-DYLFNKSLEIEPRNPKPLPRFPKKYSY 1033
            QN  + L    D+      +N +  S++   T D ++  SL +EPRN K  P  P   + 
Sbjct: 344  QNASHHLEPNMDL------INLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNK 397

Query: 1034 PLKSPGVRPSNPRPGTMRHPTP 1055
            P     V P     G M  P P
Sbjct: 398  P-----VVPLEWALGVMPKPDP 414


>gi|24762239 RAS guanyl releasing protein 3 (calcium and
            DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 88/382 (23%), Positives = 153/382 (40%), Gaps = 50/382 (13%)

Query: 686  QLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARD 745
            +L++    R+W+     +F  D  L++  EEF         +K V  I            
Sbjct: 71   RLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI---------- 120

Query: 746  NGPGHNITFQSSPPTVEW--------HISRPGHI-ETFDLLTLHPIEIARQLTLLESDLY 796
                      SS P+ +W         +S+ G     FD   L PIE+A  LT LE   +
Sbjct: 121  ----------SSIPSYDWMRRVTQRKKVSKKGKACLLFD--HLEPIELAEHLTFLEHKSF 168

Query: 797  RAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRII 856
            R +  ++    V        N+P L + I     ++ W +  ++     ++R  V+++ I
Sbjct: 169  RRISFTDYQSYVI--HGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFI 226

Query: 857  EILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKK 914
             + +   +L NFN ++ VV  ++ S + RL  T   + S   K   E  EL  S  +Y  
Sbjct: 227  NVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCN 286

Query: 915  YLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQY 974
            Y       +   +P  G++L +++      P+  +   +  +N  K  +++    E+   
Sbjct: 287  YRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTE---ENKVNIVKMHQLSVTLSELVSL 343

Query: 975  QNQPYCLRVESDIKRFFENLNPMGNSMEKEFT-DYLFNKSLEIEPRNPKPLPRFPKKYSY 1033
            QN  + L    D+      +N +  S++   T D ++  SL +EPRN K  P  P   + 
Sbjct: 344  QNASHHLEPNMDL------INLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNK 397

Query: 1034 PLKSPGVRPSNPRPGTMRHPTP 1055
            P     V P     G M  P P
Sbjct: 398  P-----VVPLEWALGVMPKPDP 414


>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1
           [Homo sapiens]
          Length = 456

 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 50/209 (23%), Positives = 104/209 (49%), Gaps = 6/209 (2%)

Query: 779 LHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKC 838
           + P ++A  LT    +L+R V   E V  V+  E     + NL  +++  + +T W    
Sbjct: 217 VEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATE 276

Query: 839 IVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQK 898
           ++  E   +R  ++ + I+I  + ++  +      VV  ++++ V RL  T+E++P + K
Sbjct: 277 VLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFK 336

Query: 899 KILEEAHELSED--HYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELI 956
            +  +   L++   ++K Y   +  + PP +PF  + L ++    EG+  ++      L+
Sbjct: 337 NLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLV----DGLV 392

Query: 957 NFSKRRKVAEITGEIQQYQNQPYCLRVES 985
           N  K   VAE    I++Y+++P CL +E+
Sbjct: 393 NIEKLHSVAEKVRTIRKYRSRPLCLDMEA 421


>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
          Length = 466

 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 94/413 (22%), Positives = 174/413 (42%), Gaps = 73/413 (17%)

Query: 595 KAGIPIIKAGTVIKLIERLTYHM------YADPNFVRTFLTTYRSFCKPQELLS----LI 644
           +AG P++        +E L  H+      Y +  ++ TFL + R F +P+ELL+    L 
Sbjct: 28  QAGQPLLDGAPSSASLETLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPRELLARVCHLC 87

Query: 645 IERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDF 704
           IE+ ++ +P   +A                 R RK        ++L +   W E    DF
Sbjct: 88  IEQQQLDKPVLDKA-----------------RVRK-----FGPKLLQLLAEWTETFPRDF 125

Query: 705 ERDAYLLQRMEEFIGTVR--GKAMKKWVESITKIIQRKKIARDNGP------GHNITFQS 756
           + ++  +  +++ +G +    +A +K +  + + + +K  A   GP         I++++
Sbjct: 126 QEES-TIGHLKDVVGRIAPCDEAYRKRMHQLLQALHQKLAALRQGPEGLVGADKPISYRT 184

Query: 757 SPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEI 816
            PP          H E   + +  P  +A+QLT +E +  R + P E V +   K+    
Sbjct: 185 KPPASI-------HRELLGVCS-DPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLAS 236

Query: 817 NSPNLLKMIRHTTNLTLWFEKC--IVETE-----NLEERVAVVSRIIEILQVFQELNNFN 869
             P       +      WF +   +V TE       ++R  V+   I++ +    + NFN
Sbjct: 237 TKPCFSDKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFN 296

Query: 870 GVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELS-EDHYKKYLAKLR-------- 920
            ++ ++S MN SPV RL  T+ ++ + +  ILE  H++    ++  Y   LR        
Sbjct: 297 SLMAIISGMNMSPVSRLKKTWAKVRTAKFFILE--HQMDPTGNFCNYRTALRGAAHRSLT 354

Query: 921 ---SINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGE 970
              S     +PFF + + +I    EG      R     +NF K  ++A+  GE
Sbjct: 355 AHSSREKIVIPFFSLLIKDIYFLNEG---CANRLPNGHVNFEKFLELAKQVGE 404


>gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
            isoform 2 [Homo sapiens]
          Length = 689

 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 91/393 (23%), Positives = 160/393 (40%), Gaps = 55/393 (13%)

Query: 686  QLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARD 745
            +L++    R+W+     +F  D  L++  EEF         +K V  I            
Sbjct: 71   RLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI---------- 120

Query: 746  NGPGHNITFQSSPPTVEW--------HISRPGHI-ETFDLLTLHPIEIARQLTLLESDLY 796
                      SS P+ +W         +S+ G     FD   L PIE+A  LT LE   +
Sbjct: 121  ----------SSIPSYDWMRRVTQRKKVSKKGKACLLFD--HLEPIELAEHLTFLEHKSF 168

Query: 797  RAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRII 856
            R +  ++    V        N+P L + I     ++ W +  ++     ++R  V+++ I
Sbjct: 169  RRISFTDYQSYVI--HGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFI 226

Query: 857  EILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKK 914
             + +   +L NFN ++ VV  ++ S + RL  T   + S   K   E  EL  S  +Y  
Sbjct: 227  NVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCN 286

Query: 915  YLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQY 974
            Y       +   +P  G++L +++      P+  +   +  +N  K  +++    E+   
Sbjct: 287  YRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTE---ENKVNIVKMHQLSVTLSELVSL 343

Query: 975  QNQPYCLRVESDIKRFFENLNPMGNSMEKEFT-DYLFNKSLEIEPRNPK--PLPRFPKKY 1031
            QN  + L    D+      +N +  S++   T D ++  SL +EPRN K    P  P K 
Sbjct: 344  QNASHHLEPNMDL------INLLTLSLDLYHTEDDIYKLSLVLEPRNSKSPTSPTTPNKP 397

Query: 1032 SYPLK-SPGVRPSNPRPGTMRHPTPLQQEPRKI 1063
              PL+ + GV P          PT + +  RK+
Sbjct: 398  VVPLEWALGVMPK-------PDPTVINKHIRKL 423


>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
          Length = 473

 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 88/401 (21%), Positives = 177/401 (44%), Gaps = 52/401 (12%)

Query: 603 AGTVIKLIERLTYHM--YADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR 660
           +G++  LI+ L  ++  Y D  ++ TFL + R F  P EL++ +            E  R
Sbjct: 40  SGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLC-------VEHQR 92

Query: 661 IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT 720
           ++  + D           K  ++ +  ++L +   W E   YDF RD  +++ +++    
Sbjct: 93  LSDPDSD-----------KNQMRKIAPKILQLLTEWTETFPYDF-RDERMMRNLKDLAHR 140

Query: 721 VRGKAMKKWVESITKIIQR--KKIARDNGPGHNITFQSSPPTVEWHI--SRPGHIETFDL 776
           +     + + +++ +++Q   +K+A  +     +   SS  T    +  ++P  I+  D+
Sbjct: 141 IASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQR-DI 199

Query: 777 LTL--HPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTL- 833
           +T+   P  +A+QLT +E +    + P E V   + ++D   N  +     + T NL   
Sbjct: 200 ITVCNDPYTLAQQLTHIELERLNYIGPEEFV-QAFVQKDPLDNDKSCYSERKKTRNLEAY 258

Query: 834 --WFEKC--IVETE-----NLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVY 884
             WF +   +V TE       + R  ++   I++ +    + NFN ++ ++S MN SPV 
Sbjct: 259 VEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVS 318

Query: 885 RLDHTFEQIPSRQKKILEEAHELSEDHY----------KKYLAKLRSINPPCVPFFGIYL 934
           RL  T+ ++ + +  ILE   + S + Y          ++ L    S     +PFF + +
Sbjct: 319 RLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLI 378

Query: 935 TNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQ 975
            +I    EG      R     +NF K  ++A+   E   ++
Sbjct: 379 KDIYFLNEG---CANRLPNGHVNFEKFWELAKQVSEFMTWK 416


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 95/391 (24%), Positives = 172/391 (43%), Gaps = 72/391 (18%)

Query: 204 LVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHI 263
           L  AF+  IRQ + +             S  K  +  +V+ +FS I DI E+    L  +
Sbjct: 71  LQSAFLHRIRQNVAD-------------SVEKGLTEENVKVLFSNIEDILEVHKDFLAAL 117

Query: 264 EDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYARDILRPGFHD---RFLSQLSKPGA 320
           E  +    + S H L G+ F    ++  F  YE Y  +      H+   R L +L+K   
Sbjct: 118 EYCLHPEPQ-SQHEL-GNVFLKFKDK--FCVYEEYCSN------HEKALRLLVELNKIPT 167

Query: 321 --ALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQE-DKECLKQAI 377
             A  L  +  G ++     L   LL+P+     Y  LLK+L +++  +  D   ++ A+
Sbjct: 168 VRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSAL 227

Query: 378 TALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDI 437
            A       M+ +CS     +R  E                ++ + ++Q +I+GWEG ++
Sbjct: 228 QA-------MKTVCSNINETKRQMEK---------------LEALEQLQSHIEGWEGSNL 265

Query: 438 GQCCNEFIMEGTLTRVGAKH--ERHIFLFDGLMICCK-------SNHGQPRLPGASNAEY 488
              C + +++GTL ++ A +  ER  FLFD L++ CK       S     R    + + Y
Sbjct: 266 TDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLY 325

Query: 489 RLKEKFFMRKVQI-NDKDDTNEY-------KHAFEIILKDENS-VIFSAKSAEEKNNWMA 539
             + +     +++ N +D T +Y        + ++I    +N   +  AK+AEEK  W+ 
Sbjct: 326 IFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLD 385

Query: 540 ALI-SLQYRSTLERML--DVTMLQEEKEEQM 567
           A+I   + R +L+  +  D  ++  EK E++
Sbjct: 386 AIIREREQRESLKLGMERDAYVMIAEKGEKL 416


>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapiens]
          Length = 762

 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 84/352 (23%), Positives = 149/352 (42%), Gaps = 30/352 (8%)

Query: 687  LRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKI-ARD 745
            L++    R+W+   +  F+ DA L   MEEF   V+ K      E   ++I   +I ARD
Sbjct: 123  LKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGE----ELHCRLIDTTQINARD 178

Query: 746  NGPGHNITFQSSPPTVEWHISRPGHIET-FDLLTLHPIEIARQLTLLESDLYRAVQPSEL 804
                     +     ++ + S+   +   FD   L P E++  LT LE   +R +  S+ 
Sbjct: 179  WS-------RKLTQRIKSNTSKKRKVSLLFD--HLEPEELSEHLTYLEFKSFRRISFSDY 229

Query: 805  VGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQE 864
               +     KE  +P + + I     ++ W +  ++     + R  V  + I++ Q   +
Sbjct: 230  QNYLVNSCVKE--NPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQ 287

Query: 865  LNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKKYLAKLRSI 922
            L NFN ++ V+  +  S + RL  T   +P    K+L E  EL  S  +Y  Y       
Sbjct: 288  LQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGEC 347

Query: 923  NPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLR 982
                +P  G++L +++   E  P+ L+  GK  +N  K   +     E+ Q Q     L 
Sbjct: 348  TDFKIPILGVHLKDLISLYEAMPDYLE-DGK--VNVHKLLALYNHISELVQLQEVAPPLE 404

Query: 983  VESDIKRFFENLNPMGNSMEKEFT-DYLFNKSLEIEPRNPKPLPRFPKKYSY 1033
               D+      ++ +  S++  +T D ++  S   EPRN +  P   K Y +
Sbjct: 405  ANKDL------VHLLTLSLDLYYTEDEIYELSYAREPRNHR-APSVFKNYDH 449


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,090,028
Number of Sequences: 37866
Number of extensions: 3355079
Number of successful extensions: 30291
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 228
Number of HSP's successfully gapped in prelim test: 1299
Number of HSP's that attempted gapping in prelim test: 17968
Number of HSP's gapped (non-prelim): 7784
length of query: 1333
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1219
effective length of database: 13,930,794
effective search space: 16981637886
effective search space used: 16981637886
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.