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Search of human proteins with 155030206
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4
isoform b [Homo sapiens]
(867 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 1747 0.0
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 1741 0.0
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 814 0.0
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 814 0.0
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 814 0.0
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 565 e-161
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 385 e-107
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 167 4e-41
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 166 7e-41
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 123 8e-28
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 123 8e-28
gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchan... 107 6e-23
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 107 6e-23
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 100 1e-20
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 100 1e-20
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 100 1e-20
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 99 2e-20
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 91 5e-18
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 91 6e-18
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 90 8e-18
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 89 2e-17
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 87 5e-17
gi|117168263 RasGEF domain family, member 1A [Homo sapiens] 71 4e-12
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 70 1e-11
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 70 1e-11
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 70 1e-11
gi|189571664 DEP domain containing 6 [Homo sapiens] 67 7e-11
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 65 2e-10
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 65 2e-10
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 64 6e-10
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 1747 bits (4524), Expect = 0.0
Identities = 867/867 (100%), Positives = 867/867 (100%)
Query: 1 MLYKKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKIL 60
MLYKKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKIL
Sbjct: 1 MLYKKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKIL 60
Query: 61 RAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQV 120
RAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQV
Sbjct: 61 RAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQV 120
Query: 121 LLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGP 180
LLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGP
Sbjct: 121 LLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGP 180
Query: 181 DAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVL 240
DAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVL
Sbjct: 181 DAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVL 240
Query: 241 FNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCH 300
FNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCH
Sbjct: 241 FNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCH 300
Query: 301 FLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGT 360
FLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGT
Sbjct: 301 FLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGT 360
Query: 361 PEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQ 420
PEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQ
Sbjct: 361 PEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQ 420
Query: 421 EKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLP 480
EKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLP
Sbjct: 421 EKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLP 480
Query: 481 ELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTI 540
ELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTI
Sbjct: 481 ELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTI 540
Query: 541 RVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACP 600
RVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACP
Sbjct: 541 RVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACP 600
Query: 601 REQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRH 660
REQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRH
Sbjct: 601 REQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRH 660
Query: 661 NFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFF 720
NFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFF
Sbjct: 661 NFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFF 720
Query: 721 AIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFM 780
AIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFM
Sbjct: 721 AIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFM 780
Query: 781 PLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVR 840
PLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVR
Sbjct: 781 PLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVR 840
Query: 841 SYVRQLNVIDNQRTLSQMSHRLEPRRP 867
SYVRQLNVIDNQRTLSQMSHRLEPRRP
Sbjct: 841 SYVRQLNVIDNQRTLSQMSHRLEPRRP 867
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform a
[Homo sapiens]
Length = 1011
Score = 1741 bits (4510), Expect = 0.0
Identities = 864/866 (99%), Positives = 866/866 (100%)
Query: 2 LYKKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKILR 61
L++KYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKILR
Sbjct: 146 LWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKILR 205
Query: 62 AGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVL 121
AGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVL
Sbjct: 206 AGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVL 265
Query: 122 LEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPD 181
LEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPD
Sbjct: 266 LEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPD 325
Query: 182 AHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLF 241
AHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLF
Sbjct: 326 AHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLF 385
Query: 242 NQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHF 301
NQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHF
Sbjct: 386 NQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHF 445
Query: 302 LRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTP 361
LRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTP
Sbjct: 446 LRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTP 505
Query: 362 EKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQE 421
EKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQE
Sbjct: 506 EKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQE 565
Query: 422 KMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPE 481
KMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPE
Sbjct: 566 KMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPE 625
Query: 482 LEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIR 541
LEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIR
Sbjct: 626 LEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIR 685
Query: 542 VPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPR 601
VPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPR
Sbjct: 686 VPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPR 745
Query: 602 EQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHN 661
EQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHN
Sbjct: 746 EQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHN 805
Query: 662 FKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 721
FKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA
Sbjct: 806 FKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 865
Query: 722 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMP 781
IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMP
Sbjct: 866 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMP 925
Query: 782 LLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRS 841
LLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRS
Sbjct: 926 LLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRS 985
Query: 842 YVRQLNVIDNQRTLSQMSHRLEPRRP 867
YVRQLNVIDNQRTLSQMSHRLEPRRP
Sbjct: 986 YVRQLNVIDNQRTLSQMSHRLEPRRP 1011
Score = 70.1 bits (170), Expect = 8e-12
Identities = 43/131 (32%), Positives = 75/131 (57%), Gaps = 9/131 (6%)
Query: 188 LRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEG 247
L K P +R+ +D++II+ L +KA + ++ +E+ KG T LF QG+ G
Sbjct: 19 LDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGIT-LFRQGDIG 77
Query: 248 TSWYIILKGSVNVVIYGKG------VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHF 301
T+WY +L GS++V + +CTL G FG+ +++++ PR A+IV RE +
Sbjct: 78 TNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESS-EL 135
Query: 302 LRVDKEDFNRI 312
LR++++DF +
Sbjct: 136 LRIEQKDFKAL 146
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 814 bits (2102), Expect = 0.0
Identities = 431/861 (50%), Positives = 593/861 (68%), Gaps = 43/861 (4%)
Query: 36 TPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGT 95
TPL L + ++ + +E++LRAG+ L +L+ P++IRDRKYHL+ YRQCC G
Sbjct: 32 TPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGR 91
Query: 96 ELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYL-FYRFLDDEHEDAP 154
ELVD ++ VHSR+Q VG+ QVLL++G L HV + FQD+ FYRF E E P
Sbjct: 92 ELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPE--P 149
Query: 155 LPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALS 214
+ T E +EEL + + LLSQ GPDA + + LRKPPGQRT ++L++I+EELLHIKA++
Sbjct: 150 VGTHE----MEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVA 205
Query: 215 HLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEG 274
HLS +VKRELA VL+FE H+K GTVLF+QG++GTSWYII KGSVNVV +GKG+V TLHEG
Sbjct: 206 HLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEG 265
Query: 275 DDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLE 334
DDFG+LALVNDAPRAA+I+LREDNCHFLRVDK+DFNRI++DVEA T+RL+EH + VLVLE
Sbjct: 266 DDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLE 325
Query: 335 KVPAGNRASNQGNSQP----QQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFI 390
+ G G S+P + +YTVMSGTPEKILE LE + +++ ++ T++ L+DF+
Sbjct: 326 RASQG-----AGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFL 380
Query: 391 MMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQE 450
+ H VFMP+ QLC AL+ H+H +P+ G+EQE+ Y N +++++RLV QW A+YG +L
Sbjct: 381 LTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHT 440
Query: 451 DDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKA-PQKKHKVLLQQFNT 509
D V+ +FL++ V D R+ L+EQ PE + + + A PQ K + L
Sbjct: 441 DPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPN 500
Query: 510 GDERAQKRQ-PIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIV 568
DE I+ D+V + + DH+ T+++PV SV+EV++A+A + G +G ++V
Sbjct: 501 QDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQVLV 560
Query: 569 KMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMS 628
K++S G+ + L+P+ V T+L +N RLF ++ L P P+Q GPTVG+ +L+S
Sbjct: 561 KVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVS 620
Query: 629 SKDLAYQMTIYDWELFNCVHELELIYHTFG-RHNFKKTTANLDLFLRRFNEIQFWVVTEI 687
+KDLA Q+T +DW LFN +H++ELI++ G +H TTANL+ F+RRFNE+Q+WV TE+
Sbjct: 621 AKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATEL 680
Query: 688 CLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKK 747
CLC R QLL+KFIK+AAH KE KNLNSFFA++ GLSN A+SRLA TWE+LP K +K
Sbjct: 681 CLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRK 740
Query: 748 FYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKM 807
Y+ E L+DPS NHR YRL +AKL PP+IPFMPLL+KDMTF HEGN T ++NL+NFEKM
Sbjct: 741 LYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKM 800
Query: 808 RMIANTARTVRYYRSQ---PFNPDAAQANKNHQDVR---------------------SYV 843
RM+A AR + + RS P +P ++ + H+D + +YV
Sbjct: 801 RMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYV 860
Query: 844 RQLNVIDNQRTLSQMSHRLEP 864
+QL VIDNQR LS++S LEP
Sbjct: 861 QQLKVIDNQRELSRLSRELEP 881
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 814 bits (2102), Expect = 0.0
Identities = 431/861 (50%), Positives = 593/861 (68%), Gaps = 43/861 (4%)
Query: 36 TPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGT 95
TPL L + ++ + +E++LRAG+ L +L+ P++IRDRKYHL+ YRQCC G
Sbjct: 32 TPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGR 91
Query: 96 ELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYL-FYRFLDDEHEDAP 154
ELVD ++ VHSR+Q VG+ QVLL++G L HV + FQD+ FYRF E E P
Sbjct: 92 ELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPE--P 149
Query: 155 LPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALS 214
+ T E +EEL + + LLSQ GPDA + + LRKPPGQRT ++L++I+EELLHIKA++
Sbjct: 150 VGTHE----MEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVA 205
Query: 215 HLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEG 274
HLS +VKRELA VL+FE H+K GTVLF+QG++GTSWYII KGSVNVV +GKG+V TLHEG
Sbjct: 206 HLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEG 265
Query: 275 DDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLE 334
DDFG+LALVNDAPRAA+I+LREDNCHFLRVDK+DFNRI++DVEA T+RL+EH + VLVLE
Sbjct: 266 DDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLE 325
Query: 335 KVPAGNRASNQGNSQP----QQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFI 390
+ G G S+P + +YTVMSGTPEKILE LE + +++ ++ T++ L+DF+
Sbjct: 326 RASQG-----AGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFL 380
Query: 391 MMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQE 450
+ H VFMP+ QLC AL+ H+H +P+ G+EQE+ Y N +++++RLV QW A+YG +L
Sbjct: 381 LTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHT 440
Query: 451 DDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKA-PQKKHKVLLQQFNT 509
D V+ +FL++ V D R+ L+EQ PE + + + A PQ K + L
Sbjct: 441 DPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPN 500
Query: 510 GDERAQKRQ-PIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIV 568
DE I+ D+V + + DH+ T+++PV SV+EV++A+A + G +G ++V
Sbjct: 501 QDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQVLV 560
Query: 569 KMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMS 628
K++S G+ + L+P+ V T+L +N RLF ++ L P P+Q GPTVG+ +L+S
Sbjct: 561 KVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVS 620
Query: 629 SKDLAYQMTIYDWELFNCVHELELIYHTFG-RHNFKKTTANLDLFLRRFNEIQFWVVTEI 687
+KDLA Q+T +DW LFN +H++ELI++ G +H TTANL+ F+RRFNE+Q+WV TE+
Sbjct: 621 AKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATEL 680
Query: 688 CLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKK 747
CLC R QLL+KFIK+AAH KE KNLNSFFA++ GLSN A+SRLA TWE+LP K +K
Sbjct: 681 CLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRK 740
Query: 748 FYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKM 807
Y+ E L+DPS NHR YRL +AKL PP+IPFMPLL+KDMTF HEGN T ++NL+NFEKM
Sbjct: 741 LYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKM 800
Query: 808 RMIANTARTVRYYRSQ---PFNPDAAQANKNHQDVR---------------------SYV 843
RM+A AR + + RS P +P ++ + H+D + +YV
Sbjct: 801 RMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYV 860
Query: 844 RQLNVIDNQRTLSQMSHRLEP 864
+QL VIDNQR LS++S LEP
Sbjct: 861 QQLKVIDNQRELSRLSRELEP 881
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
Length = 923
Score = 814 bits (2102), Expect = 0.0
Identities = 431/861 (50%), Positives = 593/861 (68%), Gaps = 43/861 (4%)
Query: 36 TPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGT 95
TPL L + ++ + +E++LRAG+ L +L+ P++IRDRKYHL+ YRQCC G
Sbjct: 74 TPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGR 133
Query: 96 ELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYL-FYRFLDDEHEDAP 154
ELVD ++ VHSR+Q VG+ QVLL++G L HV + FQD+ FYRF E E P
Sbjct: 134 ELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPE--P 191
Query: 155 LPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALS 214
+ T E +EEL + + LLSQ GPDA + + LRKPPGQRT ++L++I+EELLHIKA++
Sbjct: 192 VGTHE----MEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVA 247
Query: 215 HLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEG 274
HLS +VKRELA VL+FE H+K GTVLF+QG++GTSWYII KGSVNVV +GKG+V TLHEG
Sbjct: 248 HLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEG 307
Query: 275 DDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLE 334
DDFG+LALVNDAPRAA+I+LREDNCHFLRVDK+DFNRI++DVEA T+RL+EH + VLVLE
Sbjct: 308 DDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLE 367
Query: 335 KVPAGNRASNQGNSQP----QQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFI 390
+ G G S+P + +YTVMSGTPEKILE LE + +++ ++ T++ L+DF+
Sbjct: 368 RASQG-----AGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFL 422
Query: 391 MMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQE 450
+ H VFMP+ QLC AL+ H+H +P+ G+EQE+ Y N +++++RLV QW A+YG +L
Sbjct: 423 LTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHT 482
Query: 451 DDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKA-PQKKHKVLLQQFNT 509
D V+ +FL++ V D R+ L+EQ PE + + + A PQ K + L
Sbjct: 483 DPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPN 542
Query: 510 GDERAQKRQ-PIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIV 568
DE I+ D+V + + DH+ T+++PV SV+EV++A+A + G +G ++V
Sbjct: 543 QDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQVLV 602
Query: 569 KMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMS 628
K++S G+ + L+P+ V T+L +N RLF ++ L P P+Q GPTVG+ +L+S
Sbjct: 603 KVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVS 662
Query: 629 SKDLAYQMTIYDWELFNCVHELELIYHTFG-RHNFKKTTANLDLFLRRFNEIQFWVVTEI 687
+KDLA Q+T +DW LFN +H++ELI++ G +H TTANL+ F+RRFNE+Q+WV TE+
Sbjct: 663 AKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATEL 722
Query: 688 CLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKK 747
CLC R QLL+KFIK+AAH KE KNLNSFFA++ GLSN A+SRLA TWE+LP K +K
Sbjct: 723 CLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRK 782
Query: 748 FYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKM 807
Y+ E L+DPS NHR YRL +AKL PP+IPFMPLL+KDMTF HEGN T ++NL+NFEKM
Sbjct: 783 LYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKM 842
Query: 808 RMIANTARTVRYYRSQ---PFNPDAAQANKNHQDVR---------------------SYV 843
RM+A AR + + RS P +P ++ + H+D + +YV
Sbjct: 843 RMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYV 902
Query: 844 RQLNVIDNQRTLSQMSHRLEP 864
+QL VIDNQR LS++S LEP
Sbjct: 903 QQLKVIDNQRELSRLSRELEP 923
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 565 bits (1456), Expect = e-161
Identities = 321/757 (42%), Positives = 469/757 (61%), Gaps = 34/757 (4%)
Query: 114 AVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTML 173
A+G+WQ+LL+ G++ VDQ +FQD Y+FY+F DE E E EE Q+ +
Sbjct: 2 AIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFERE-----EEWQNGVK 56
Query: 174 LLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESH 233
LL Q+ P R + + Q+ ++D E +E+L L++ V+RELA V+ ++
Sbjct: 57 LLLQLVPLIPARGGICELSHQK-IEDSEESSDEIL-----VRLTSAVQRELAAVIALKAR 110
Query: 234 AKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIV 293
Q EE ++ + + +V GV+C L E D+ G++ LV
Sbjct: 111 KSA----IEQDEENNDKHVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQK-------- 158
Query: 294 LREDNCHFLRVDKEDFNRIL-RDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQ 352
L ++N FL+ DK++ + +D E TV++KE DQ VLVL+KV A G+++
Sbjct: 159 LAKENYQFLQTDKKEQEKSEHQDDEVTTVQVKEQDQSVLVLKKVQCCGPAPTAGSAESHW 218
Query: 353 KYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHA 412
+Y V+SGTPEKILEH L + LE ++ T+++L+DF++ + VFM LC AL+ HY A
Sbjct: 219 RYVVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSA 278
Query: 413 QPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMI 472
+ QG E E D KR+V+ LV QW A+Y D L ED+ S FL+ Y +V DD
Sbjct: 279 KKYQGKE-ENSDVP-RRKRKVLHLVSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEY 336
Query: 473 AALKEQLPELEKIV---KQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFK 529
L+++L E +KI+ ++ + D +PQKK+K L QF+ + Q R + ++E+
Sbjct: 337 PILEKELKEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCH 396
Query: 530 VYCMDHTYTTIRVPVATSVKEVISAVADKLG-SGEGLIIVKMSSGGEKVVLKPNDVSVFT 588
VY +H+Y +++ V++ +E++ VA+K+ + E L +V ++ GEK L+PND+ +
Sbjct: 397 VYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISK 456
Query: 589 TLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVH 648
+L +GR++ ++ D+L P E E ++ M++ DLA ++ +DW LFN +H
Sbjct: 457 SLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILG-MNTWDLALELMNFDWSLFNSIH 515
Query: 649 ELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAA 708
E ELIY TF R + TANL L L+R NE+Q WV TEI LCSQL KRVQL+KKFIKIAA
Sbjct: 516 EQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAA 575
Query: 709 HCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLT 768
HCK +NLNSFFAIVMGL+ +VSRL+ TWEK+P KFKK ++E ESL DPS NH+AYR
Sbjct: 576 HCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDA 635
Query: 769 VAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPD 828
K++PP IPFMPLL+KD+TF HEGNKTF+DNLVNFEK+ MIA+T RT+R+ R+ F
Sbjct: 636 FKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGD- 694
Query: 829 AAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPR 865
+ K HQ+++SYV L VID+Q+ L ++SHR+EPR
Sbjct: 695 --LSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPR 729
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1
[Homo sapiens]
Length = 456
Score = 385 bits (989), Expect = e-107
Identities = 196/448 (43%), Positives = 289/448 (64%), Gaps = 13/448 (2%)
Query: 427 LNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIV 486
L K+ + ++L + Y LLQE++ + +++ Y+ + D + L+E L ++V
Sbjct: 7 LGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTLRLHQLV 66
Query: 487 K----QISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRV 542
+ +I E+ + P K+ K L + F D Q R RGSDE+ +VY DH+Y TIR
Sbjct: 67 ETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRS 126
Query: 543 PVATSVKEVISAVADKL-------GSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGR 595
++ SV++++ +V +KL G + LI+V +SS GEKV+L+P + VFT L IN
Sbjct: 127 RLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGINSH 186
Query: 596 LFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYH 655
LFAC R+ +++L PLPE+ + G + +D+A +T + WELF CVHELE + +
Sbjct: 187 LFACTRDSYEALVPLPEEIQVSPGDT-EIHRVEPEDVANHLTAFHWELFRCVHELEFVDY 245
Query: 656 TFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKN 715
F ++ TANL+L L+R +E+ WV TE+ LC KR QLLKKFIKIAA CK+ ++
Sbjct: 246 VFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQD 305
Query: 716 LNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPP 775
L SF+A+VMGL N AVSRL LTWEKLP KFK + +FE+L DP RNH++YR ++K++PP
Sbjct: 306 LLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKPP 365
Query: 776 LIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKN 835
+IPF+PL++KD+TF HEG+KT +D LVN EK+ +A RT+R YRS+P D +A+ N
Sbjct: 366 VIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLD-MEASPN 424
Query: 836 HQDVRSYVRQLNVIDNQRTLSQMSHRLE 863
H ++YVRQ VIDNQ L ++S++LE
Sbjct: 425 HLQTKAYVRQFQVIDNQNLLFELSYKLE 452
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 167 bits (423), Expect = 4e-41
Identities = 89/203 (43%), Positives = 127/203 (62%), Gaps = 3/203 (1%)
Query: 627 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 686
+S+ ++A Q+++ ++ELF + E I F + K + ANL F N+ FWV +E
Sbjct: 716 LSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRS-KTSCANLKRFEEVINQETFWVASE 774
Query: 687 ICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFK 746
I + KR++++K FIKIA HC+E KN NS FAI+ GL+ V+RL TWEKLP+K++
Sbjct: 775 ILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYE 834
Query: 747 KFYAEFESLMDPSRNHRAYR--LTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNF 804
K + + + L DPSRN YR L L+PP+IP P++ KD+TF HEGN + +D LVNF
Sbjct: 835 KLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNF 894
Query: 805 EKMRMIANTARTVRYYRSQPFNP 827
EK+RMIA R V S +P
Sbjct: 895 EKLRMIAKEIRHVGRMASVNMDP 917
Score = 107 bits (266), Expect = 6e-23
Identities = 81/307 (26%), Positives = 142/307 (46%), Gaps = 27/307 (8%)
Query: 155 LPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALS 214
LP E D++ +D + +R L K P RT DD+E + E + + A +
Sbjct: 78 LPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFA 137
Query: 215 HLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEG 274
+++ +V+REL V++F + GT++ N GEE SW +IL GSV V Y G L G
Sbjct: 138 NMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVT-YPDGKAEILCMG 196
Query: 275 DDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLE 334
+ FG ++ + + D+C F+ + ++D+ RIL VE N +++E + V+V E
Sbjct: 197 NSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKE 256
Query: 335 KVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHC 394
+ +G + V+ GT E++ H +E E ++ + T + DF++ +
Sbjct: 257 HRELDRTGTRKG-------HIVIKGTSERLTMHLVE----EHSVVDPT--FIEDFLLTYR 303
Query: 395 VFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVS 454
F+ + + + PS + +V R+VL W + + + D
Sbjct: 304 TFLSSPMEVGKKLLEWFNDPSL-------------RDKVTRVVLLWVNNHFNDFEGDPAM 350
Query: 455 MAFLEEF 461
FLEEF
Sbjct: 351 TRFLEEF 357
>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
I [Homo sapiens]
Length = 1601
Score = 166 bits (421), Expect = 7e-41
Identities = 106/313 (33%), Positives = 172/313 (54%), Gaps = 11/313 (3%)
Query: 524 DEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLG---SGEGLIIVKMSSGGEKVVLK 580
D+V+ +V+ +D I + T+ KEV+ + G + + + ++S E V+ +
Sbjct: 750 DQVI-RVFKVDQQSCYIIISKDTTAKEVVFHAVHEFGLTGASDTYSLCEVSVTPEGVIKQ 808
Query: 581 PNDVSVFTTLT----INGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM 636
F+ L +NGR + + ++L + + + + +S+ ++A Q+
Sbjct: 809 RRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQL 868
Query: 637 TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR 696
++ D++LF + E I F + N K +L F N+ FWV +EI + KR
Sbjct: 869 SMRDFDLFRNIEPTEYIDDLF-KLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKR 927
Query: 697 VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM 756
++++K FIKIA HC+E KN NS FAI+ GL+ +V+RL TWEKLPSK++K + + +
Sbjct: 928 MKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIF 987
Query: 757 DPSRNHRAYR--LTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTA 814
DPSRN YR L+ ++PP+IP P++ KDMTF HEGN + +D LVNFEK+RMI+
Sbjct: 988 DPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEI 1047
Query: 815 RTVRYYRSQPFNP 827
R V S +P
Sbjct: 1048 RQVVRMTSANMDP 1060
Score = 113 bits (283), Expect = 7e-25
Identities = 88/316 (27%), Positives = 161/316 (50%), Gaps = 32/316 (10%)
Query: 152 DAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIK 211
+ P+ +E++++E DEE+ T L G D +R L K P +T DD+E + E + +
Sbjct: 225 EGPVDSEDDEEE-DEEIDRTDPL---QGRDL-VRECLEKEPADKTDDDIEQLLEFMHQLP 279
Query: 212 ALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTL 271
A ++++ +V+REL V+IFE + G ++ G+E SWY+IL G+V + + G V L
Sbjct: 280 AFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVE-ISHPDGKVENL 338
Query: 272 HEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVL 331
G+ FG ++ + + D+C F+ + ++D+ RIL VE NT +++E + V+
Sbjct: 339 FMGNSFGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVM 398
Query: 332 VLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIM 391
V E + +G + V+ TPE+++ H +E E ++ + T + DF++
Sbjct: 399 VHEHRELDRSGTRKG-------HIVIKATPERLIMHLIE----EHSIVDPT--YIEDFLL 445
Query: 392 MHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQED 451
+ F+ + P V + E K+D + + +V R+VL W + + + D
Sbjct: 446 TYRTFLES----PLDVG------IKLLEWFKID---SLRDKVTRIVLLWVNNHFNDFEGD 492
Query: 452 DVSMAFLEEFYVSVSD 467
FLEEF ++ D
Sbjct: 493 PAMTRFLEEFEKNLED 508
Score = 47.0 bits (110), Expect = 8e-05
Identities = 34/98 (34%), Positives = 48/98 (48%), Gaps = 3/98 (3%)
Query: 181 DAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVL 240
D R LRK P +RT +DL IY L ++ LS+L R ++ +E ++ G VL
Sbjct: 6 DPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYS-GNQVL 64
Query: 241 FNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFG 278
F WYI+L GS V++ G V+ G FG
Sbjct: 65 FCSETIARCWYILLSGS--VLVKGSMVLPPCSFGKQFG 100
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 123 bits (308), Expect = 8e-28
Identities = 74/244 (30%), Positives = 132/244 (54%), Gaps = 13/244 (5%)
Query: 622 GTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQF 681
GT S ++A Q+T+ D ELF + E++ + + ++ + NL F FN + +
Sbjct: 852 GTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSY 909
Query: 682 WVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKL 741
WV + I L + R +LL KFIKI H ++ N NS+ AI+ L + + RL W+K
Sbjct: 910 WVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQKQ 967
Query: 742 PSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNL 801
S+ AE+ +L+D S + RAYR ++++EPP IP++ L+++D+TF H GN +ID
Sbjct: 968 TSEG---LAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGK 1024
Query: 802 VNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHR 861
VNF K N ++R ++ ++ + + D+ ++ + + L ++S +
Sbjct: 1025 VNFSKRWQQFNILDSMRCFQQAHYD------MRRNDDIINFFNDFSDHLAEEALWELSLK 1078
Query: 862 LEPR 865
++PR
Sbjct: 1079 IKPR 1082
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 123 bits (308), Expect = 8e-28
Identities = 74/244 (30%), Positives = 132/244 (54%), Gaps = 13/244 (5%)
Query: 622 GTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQF 681
GT S ++A Q+T+ D ELF + E++ + + ++ + NL F FN + +
Sbjct: 834 GTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSY 891
Query: 682 WVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKL 741
WV + I L + R +LL KFIKI H ++ N NS+ AI+ L + + RL W+K
Sbjct: 892 WVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQKQ 949
Query: 742 PSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNL 801
S+ AE+ +L+D S + RAYR ++++EPP IP++ L+++D+TF H GN +ID
Sbjct: 950 TSEG---LAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGK 1006
Query: 802 VNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHR 861
VNF K N ++R ++ ++ + + D+ ++ + + L ++S +
Sbjct: 1007 VNFSKRWQQFNILDSMRCFQQAHYD------MRRNDDIINFFNDFSDHLAEEALWELSLK 1060
Query: 862 LEPR 865
++PR
Sbjct: 1061 IKPR 1064
>gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchange
factor 2, partial [Homo sapiens]
Length = 803
Score = 107 bits (266), Expect = 6e-23
Identities = 81/307 (26%), Positives = 142/307 (46%), Gaps = 27/307 (8%)
Query: 155 LPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALS 214
LP E D++ +D + +R L K P RT DD+E + E + + A +
Sbjct: 78 LPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFA 137
Query: 215 HLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEG 274
+++ +V+REL V++F + GT++ N GEE SW +IL GSV V Y G L G
Sbjct: 138 NMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVT-YPDGKAEILCMG 196
Query: 275 DDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLE 334
+ FG ++ + + D+C F+ + ++D+ RIL VE N +++E + V+V E
Sbjct: 197 NSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKE 256
Query: 335 KVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHC 394
+ +G + V+ GT E++ H +E E ++ + T + DF++ +
Sbjct: 257 HRELDRTGTRKG-------HIVIKGTSERLTMHLVE----EHSVVDPT--FIEDFLLTYR 303
Query: 395 VFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVS 454
F+ + + + PS + +V R+VL W + + + D
Sbjct: 304 TFLSSPMEVGKKLLEWFNDPSL-------------RDKVTRVVLLWVNNHFNDFEGDPAM 350
Query: 455 MAFLEEF 461
FLEEF
Sbjct: 351 TRFLEEF 357
Score = 58.9 bits (141), Expect = 2e-08
Identities = 33/89 (37%), Positives = 53/89 (59%), Gaps = 1/89 (1%)
Query: 627 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 686
+S+ ++A Q+++ ++ELF + E I F + K + ANL F N+ FWV +E
Sbjct: 716 LSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRS-KTSCANLKRFEEVINQETFWVASE 774
Query: 687 ICLCSQLSKRVQLLKKFIKIAAHCKEYKN 715
I + KR++++K FIKIA HC+E KN
Sbjct: 775 ILRETNQLKRMKIIKHFIKIALHCRECKN 803
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 107 bits (266), Expect = 6e-23
Identities = 63/245 (25%), Positives = 121/245 (49%), Gaps = 7/245 (2%)
Query: 624 FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 683
FE +S+ +LA Q+T+ D +F + E + + + + + T + + FN++ V
Sbjct: 998 FESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLV 1057
Query: 684 VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 743
++I + +S R ++K++ +A C+ N N I L+ A+ RL TW K+
Sbjct: 1058 ASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSK 1117
Query: 744 KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 802
+ K + + + + R T+ PP +P++ + + D+ F EG F + LV
Sbjct: 1118 QTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLV 1177
Query: 803 NFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL 862
NF KMRMI++ R +R ++ + D + V Y+ ++I ++ TL ++S ++
Sbjct: 1178 NFSKMRMISHIIREIRQFQQTSYRID------HQPKVAQYLLDKDLIIDEDTLYELSLKI 1231
Query: 863 EPRRP 867
EPR P
Sbjct: 1232 EPRLP 1236
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 99.8 bits (247), Expect = 1e-20
Identities = 60/245 (24%), Positives = 118/245 (48%), Gaps = 7/245 (2%)
Query: 624 FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 683
FE S+ ++A Q+T+ D +F + E + + + T + + FN+I +
Sbjct: 1018 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 1077
Query: 684 VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 743
+EI ++ RV ++K++ +A C+ N N+ I ++ A+ RL TW K+
Sbjct: 1078 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 1137
Query: 744 KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 802
+ K + + L+ + R + +PP +P++ + + D+ F EG + D LV
Sbjct: 1138 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 1197
Query: 803 NFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL 862
NF KMRMI++ R +R ++ A ++ V Y+ + + ++ +L + S R+
Sbjct: 1198 NFSKMRMISHIIREIRQFQ------QTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRI 1251
Query: 863 EPRRP 867
EP+ P
Sbjct: 1252 EPKLP 1256
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 99.8 bits (247), Expect = 1e-20
Identities = 60/245 (24%), Positives = 118/245 (48%), Gaps = 7/245 (2%)
Query: 624 FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 683
FE S+ ++A Q+T+ D +F + E + + + T + + FN+I +
Sbjct: 1034 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 1093
Query: 684 VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 743
+EI ++ RV ++K++ +A C+ N N+ I ++ A+ RL TW K+
Sbjct: 1094 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 1153
Query: 744 KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 802
+ K + + L+ + R + +PP +P++ + + D+ F EG + D LV
Sbjct: 1154 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 1213
Query: 803 NFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL 862
NF KMRMI++ R +R ++ A ++ V Y+ + + ++ +L + S R+
Sbjct: 1214 NFSKMRMISHIIREIRQFQ------QTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRI 1267
Query: 863 EPRRP 867
EP+ P
Sbjct: 1268 EPKLP 1272
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 99.8 bits (247), Expect = 1e-20
Identities = 60/245 (24%), Positives = 118/245 (48%), Gaps = 7/245 (2%)
Query: 624 FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 683
FE S+ ++A Q+T+ D +F + E + + + T + + FN+I +
Sbjct: 250 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 309
Query: 684 VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 743
+EI ++ RV ++K++ +A C+ N N+ I ++ A+ RL TW K+
Sbjct: 310 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 369
Query: 744 KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 802
+ K + + L+ + R + +PP +P++ + + D+ F EG + D LV
Sbjct: 370 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 429
Query: 803 NFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL 862
NF KMRMI++ R +R ++ A ++ V Y+ + + ++ +L + S R+
Sbjct: 430 NFSKMRMISHIIREIRQFQ------QTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRI 483
Query: 863 EPRRP 867
EP+ P
Sbjct: 484 EPKLP 488
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 99.0 bits (245), Expect = 2e-20
Identities = 69/276 (25%), Positives = 126/276 (45%), Gaps = 20/276 (7%)
Query: 604 FDSLTPLPEQEGPTVGTVGTFELMSSK--DLAYQMTIYDWELFNCVHELELIYHTFGRHN 661
F S P E G + TF+L++ ++A Q+T+ + +L+ V EL+ + + +
Sbjct: 754 FQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKED 813
Query: 662 FKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 721
+ + NL +R + W I L +RV ++ + I+I +E N N
Sbjct: 814 KEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLE 873
Query: 722 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMP 781
+V +++ V RL T+E++PS+ KK E L + +++ Y + + PP +PF
Sbjct: 874 VVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSED--HYKKYLAKLRSINPPCVPFFG 931
Query: 782 LLIKDMTFTHEGN----KTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQ 837
+ + ++ T EGN K L+NF K R +A ++ Y++QP+ +
Sbjct: 932 IYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPY------CLRVES 985
Query: 838 DVRSYVRQLNVIDNQRT------LSQMSHRLEPRRP 867
D++ + LN + N L S +EPR P
Sbjct: 986 DIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNP 1021
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 90.9 bits (224), Expect = 5e-18
Identities = 62/183 (33%), Positives = 94/183 (51%), Gaps = 17/183 (9%)
Query: 662 FKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 721
F T+NL+ +++ FN + + V TEIC+ ++ +R Q+++ FI +A C N NS A
Sbjct: 241 FSDKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMA 300
Query: 722 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTV-----------A 770
I+ G++ VSRL TW K+ + KF+ E MDP+ N YR + +
Sbjct: 301 IISGMNMSPVSRLKKTWAKV--RTAKFFI-LEHQMDPTGNFCNYRTALRGAAHRSLTAHS 357
Query: 771 KLEPPLIPFMPLLIKDMTFTHEGNKTFIDN-LVNFEKMRMIANTARTVRYYRSQ--PFNP 827
E +IPF LLIKD+ F +EG + N VNFEK +A ++ PF
Sbjct: 358 SREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQ 417
Query: 828 DAA 830
DA+
Sbjct: 418 DAS 420
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 90.5 bits (223), Expect = 6e-18
Identities = 65/251 (25%), Positives = 119/251 (47%), Gaps = 16/251 (6%)
Query: 604 FDSLTPLPEQEGPTVGTVGTFELMSSK--DLAYQMTIYDWELFNCVHELELIYHTFGRHN 661
F+S P E G TF+LM+ ++A Q+T+ + +L+ V EL+ + + +
Sbjct: 752 FESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKED 811
Query: 662 FKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 721
+ + NL +R + W I +RV +L + I+I ++ N N
Sbjct: 812 KEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLE 871
Query: 722 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNH-RAYRLTVAKLEPPLIPFM 780
IV +++V+V RL T+E L + +K E L S++H + Y + + + PP +PF
Sbjct: 872 IVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL---SQDHFKKYLVKLKSINPPCVPFF 928
Query: 781 PLLIKDMTFTHEGNKTFI----DNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNH 836
+ + ++ T EGN F+ +L+NF K R +A ++ Y++QP+ +
Sbjct: 929 GIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPY------CLRIE 982
Query: 837 QDVRSYVRQLN 847
D+R + LN
Sbjct: 983 PDMRRFFENLN 993
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 90.1 bits (222), Expect = 8e-18
Identities = 53/192 (27%), Positives = 93/192 (48%), Gaps = 1/192 (0%)
Query: 627 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 686
++ ++ A Q+T+ D +F + EL + + + N F RRFN + FWVV E
Sbjct: 48 VTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVRE 107
Query: 687 ICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFK 746
I L R ++L +IK A E NL++ A+V GL + + RL TW L K K
Sbjct: 108 ILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDK 167
Query: 747 KFYAEFESLMDPSRNHRAYRLTVAKLE-PPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFE 805
+ + E +M N++ R ++ L+ P IP++ + + D+T+ + L N +
Sbjct: 168 TTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENEQ 227
Query: 806 KMRMIANTARTV 817
+ ++ N R +
Sbjct: 228 RSNLMNNILRII 239
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 88.6 bits (218), Expect = 2e-17
Identities = 66/201 (32%), Positives = 97/201 (48%), Gaps = 24/201 (11%)
Query: 632 LAYQMTIYDWELFNCVHELELIYHTFGR---------HNFKKTTANLDLFLRRFNEIQFW 682
LA Q+T + E N + E + + ++ +K T NL+ ++ FN + +
Sbjct: 209 LAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYL 268
Query: 683 VVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLP 742
V TEIC+ + R ++++ FI +A C N NS AI+ G++ VSRL TW K+
Sbjct: 269 VATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV- 327
Query: 743 SKFKKFYAEFESLMDPSRNHRAYRLTV-----------AKLEPPLIPFMPLLIKDMTFTH 791
K KF E MDPS N YR + + E +IPF LLIKD+ F +
Sbjct: 328 -KTAKFDI-LEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLN 385
Query: 792 EGNKTFIDN-LVNFEKMRMIA 811
EG + N VNFEK +A
Sbjct: 386 EGCANRLPNGHVNFEKFWELA 406
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 87.4 bits (215), Expect = 5e-17
Identities = 51/192 (26%), Positives = 90/192 (46%), Gaps = 1/192 (0%)
Query: 627 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 686
++ ++ A Q+T+ D +F + EL + + N+ F RRFN++ FWVV E
Sbjct: 49 VTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVRE 108
Query: 687 ICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFK 746
I L R ++L F+KIA E NL+S ++V L + + RL TW L K K
Sbjct: 109 ILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDK 168
Query: 747 KFYAEFESLMDPSRNHRAYRLTVAKLE-PPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFE 805
+ + + LM N++ R + L+ P IP++ + + D+ + + N +
Sbjct: 169 TTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQ 228
Query: 806 KMRMIANTARTV 817
+ + N R +
Sbjct: 229 RSNQMNNILRII 240
>gi|117168263 RasGEF domain family, member 1A [Homo sapiens]
Length = 481
Score = 71.2 bits (173), Expect = 4e-12
Identities = 55/182 (30%), Positives = 87/182 (47%), Gaps = 16/182 (8%)
Query: 637 TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR 696
+IY +L V ++ + + R + KT + L+ + FN + V TE+C + R
Sbjct: 232 SIYPEDLMQIVSHMDSLDNHRCRGDLTKTYS-LEAYDNWFNCLSMLVATEVCRVVKKKHR 290
Query: 697 VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM 756
++L+ FI +A C N NS AI+ G++ V+RL TW K+ K KF E M
Sbjct: 291 TRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV--KTAKFDV-LEHHM 347
Query: 757 DPSRNHRAYRLTV-----------AKLEPPLIPFMPLLIKDMTFTHEGNKTFIDN-LVNF 804
DPS N YR + + E +IP L +KD+ F H+ + + N +NF
Sbjct: 348 DPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINF 407
Query: 805 EK 806
+K
Sbjct: 408 KK 409
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 69.7 bits (169), Expect = 1e-11
Identities = 50/191 (26%), Positives = 89/191 (46%), Gaps = 3/191 (1%)
Query: 624 FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 683
F+ + +LA +T + + F + + Y ++ H + L+ + FN I WV
Sbjct: 148 FDHLEPIELAEHLTFLEHKSFRRISFTD--YQSYVIHGCLENNPTLERSIALFNGISKWV 205
Query: 684 VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 743
+ +R +++ KFI +A + KN N+ A+V GLS+ ++SRL T L S
Sbjct: 206 QLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSS 265
Query: 744 KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 802
+ K + E L+ + N+ YR A + IP + + +KD+ H + +N V
Sbjct: 266 EVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKV 325
Query: 803 NFEKMRMIANT 813
N KM ++ T
Sbjct: 326 NIVKMHQLSVT 336
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 69.7 bits (169), Expect = 1e-11
Identities = 50/191 (26%), Positives = 89/191 (46%), Gaps = 3/191 (1%)
Query: 624 FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 683
F+ + +LA +T + + F + + Y ++ H + L+ + FN I WV
Sbjct: 148 FDHLEPIELAEHLTFLEHKSFRRISFTD--YQSYVIHGCLENNPTLERSIALFNGISKWV 205
Query: 684 VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 743
+ +R +++ KFI +A + KN N+ A+V GLS+ ++SRL T L S
Sbjct: 206 QLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSS 265
Query: 744 KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 802
+ K + E L+ + N+ YR A + IP + + +KD+ H + +N V
Sbjct: 266 EVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKV 325
Query: 803 NFEKMRMIANT 813
N KM ++ T
Sbjct: 326 NIVKMHQLSVT 336
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 69.7 bits (169), Expect = 1e-11
Identities = 50/191 (26%), Positives = 89/191 (46%), Gaps = 3/191 (1%)
Query: 624 FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 683
F+ + +LA +T + + F + + Y ++ H + L+ + FN I WV
Sbjct: 148 FDHLEPIELAEHLTFLEHKSFRRISFTD--YQSYVIHGCLENNPTLERSIALFNGISKWV 205
Query: 684 VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 743
+ +R +++ KFI +A + KN N+ A+V GLS+ ++SRL T L S
Sbjct: 206 QLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSS 265
Query: 744 KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 802
+ K + E L+ + N+ YR A + IP + + +KD+ H + +N V
Sbjct: 266 EVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKV 325
Query: 803 NFEKMRMIANT 813
N KM ++ T
Sbjct: 326 NIVKMHQLSVT 336
>gi|189571664 DEP domain containing 6 [Homo sapiens]
Length = 409
Score = 67.0 bits (162), Expect = 7e-11
Identities = 35/87 (40%), Positives = 51/87 (58%), Gaps = 5/87 (5%)
Query: 77 MIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEH-H 135
+I+DR++HLKTY C V EL+DW+++ R A+ + Q L + G+++HV EH
Sbjct: 49 VIKDRRHHLKTYPNCFVAKELIDWLIEHKE-ASDRETAIKLMQKLADRGIIHHVCDEHKE 107
Query: 136 FQDKYLFYRFLDDEHEDAPLPTEEEKK 162
F+D LFYRF D D P + E K
Sbjct: 108 FKDVKLFYRFRKD---DGTFPLDNEVK 131
Score = 46.6 bits (109), Expect = 1e-04
Identities = 29/125 (23%), Positives = 57/125 (45%), Gaps = 2/125 (1%)
Query: 58 KILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGM 117
K G+ L ++S +++ R+ Y + + +E +DW++Q+ +R +A +
Sbjct: 131 KAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEAT-TRKEAEQL 189
Query: 118 WQVLLEDGVLNHVDQEHHFQDKYLFYRF-LDDEHEDAPLPTEEEKKECDEELQDTMLLLS 176
L+E G++ HV +H F D L Y+F ++ + EK +E D+ L
Sbjct: 190 CHRLMEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQETHDSPFCLR 249
Query: 177 QMGPD 181
+ D
Sbjct: 250 KQSHD 254
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 65.5 bits (158), Expect = 2e-10
Identities = 54/244 (22%), Positives = 109/244 (44%), Gaps = 10/244 (4%)
Query: 624 FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 683
F+ + ++L+ +T +++ F + + Y + ++ K ++ + N I WV
Sbjct: 201 FDHLEPEELSEHLTYLEFKSFRRISFSD--YQNYLVNSCVKENPTMERSIALCNGISQWV 258
Query: 684 VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 743
+ R ++ KFI++A + +N N+ A++ GL + ++SRL T +P
Sbjct: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
Query: 744 KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 802
+ K E L+ SRN+ YR + IP + + +KD+ +E ++ D V
Sbjct: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
Query: 803 NFEKMRMIAN-TARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHR 861
N K+ + N + V+ P +ANK+ V L++ + + ++S+
Sbjct: 379 NVHKLLALYNHISELVQLQEVAP----PLEANKDL--VHLLTLSLDLYYTEDEIYELSYA 432
Query: 862 LEPR 865
EPR
Sbjct: 433 REPR 436
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 65.5 bits (158), Expect = 2e-10
Identities = 54/244 (22%), Positives = 109/244 (44%), Gaps = 10/244 (4%)
Query: 624 FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 683
F+ + ++L+ +T +++ F + + Y + ++ K ++ + N I WV
Sbjct: 201 FDHLEPEELSEHLTYLEFKSFRRISFSD--YQNYLVNSCVKENPTMERSIALCNGISQWV 258
Query: 684 VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 743
+ R ++ KFI++A + +N N+ A++ GL + ++SRL T +P
Sbjct: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
Query: 744 KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 802
+ K E L+ SRN+ YR + IP + + +KD+ +E ++ D V
Sbjct: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
Query: 803 NFEKMRMIAN-TARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHR 861
N K+ + N + V+ P +ANK+ V L++ + + ++S+
Sbjct: 379 NVHKLLALYNHISELVQLQEVAP----PLEANKDL--VHLLTLSLDLYYTEDEIYELSYA 432
Query: 862 LEPR 865
EPR
Sbjct: 433 REPR 436
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 63.9 bits (154), Expect = 6e-10
Identities = 34/93 (36%), Positives = 55/93 (59%), Gaps = 1/93 (1%)
Query: 57 EKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVG 116
E I+ G L + S +I+DR YHLKTY+ G++LVDW++ Q C +R +AV
Sbjct: 508 EDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDC-QTREEAVA 566
Query: 117 MWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDE 149
+ L +G ++HV ++ F+D+ ++RF DE
Sbjct: 567 LGVGLCNNGFMHHVLEKSEFRDESQYFRFHADE 599
Score = 60.8 bits (146), Expect = 5e-09
Identities = 36/149 (24%), Positives = 75/149 (50%), Gaps = 16/149 (10%)
Query: 59 ILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMW 118
I G+ L + ++++ ++I+DR+ L T +C +G E V W+++ + + V +
Sbjct: 409 IAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGE-ISKTEEGVNLG 467
Query: 119 QVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQM 178
Q LLE+G+++HV +H F+++ + YRF D+ T + + E ++ + + L ++
Sbjct: 468 QALLENGIIHHVSDKHQFKNEQVMYRFRYDD------GTYKARSELEDIMSKGVRLYCRL 521
Query: 179 ---------GPDAHMRMILRKPPGQRTVD 198
D H++ PG + VD
Sbjct: 522 HSLYTPVIKDRDYHLKTYKSVLPGSKLVD 550
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,696,449
Number of Sequences: 37866
Number of extensions: 1482782
Number of successful extensions: 4585
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 42
Number of HSP's that attempted gapping in prelim test: 4377
Number of HSP's gapped (non-prelim): 176
length of query: 867
length of database: 18,247,518
effective HSP length: 111
effective length of query: 756
effective length of database: 14,044,392
effective search space: 10617560352
effective search space used: 10617560352
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.