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Search of human proteins with 154689780
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154689780 son of sevenless homolog 2 [Homo sapiens]
(1332 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 2718 0.0
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 1850 0.0
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 152 3e-36
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 152 3e-36
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 152 3e-36
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 147 5e-35
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 135 2e-31
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 135 2e-31
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 119 1e-26
gi|239582765 ral guanine nucleotide dissociation stimulator-like... 104 5e-22
gi|239582763 ral guanine nucleotide dissociation stimulator-like... 104 5e-22
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2... 102 2e-21
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 102 3e-21
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 101 5e-21
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 91 1e-17
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 91 1e-17
gi|24307909 ral guanine nucleotide dissociation stimulator isofo... 88 6e-17
gi|108796058 ral guanine nucleotide dissociation stimulator isof... 88 6e-17
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 81 6e-15
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 81 6e-15
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 80 1e-14
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 79 4e-14
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 78 5e-14
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 76 2e-13
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 75 3e-13
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 75 5e-13
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 75 5e-13
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 73 2e-12
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 72 3e-12
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 72 5e-12
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 2718 bits (7046), Expect = 0.0
Identities = 1332/1332 (100%), Positives = 1332/1332 (100%)
Query: 1 MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLC 60
MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLC
Sbjct: 1 MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLC 60
Query: 61 MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY 120
MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY
Sbjct: 61 MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY 120
Query: 121 KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD 180
KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD
Sbjct: 121 KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD 180
Query: 181 IGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDI 240
IGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDI
Sbjct: 181 IGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDI 240
Query: 241 EKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI 300
EKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI
Sbjct: 241 EKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI 300
Query: 301 LSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKA 360
LSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKA
Sbjct: 301 LSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKA 360
Query: 361 CSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKM 420
CSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKM
Sbjct: 361 CSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKM 420
Query: 421 NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPG 480
NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPG
Sbjct: 421 NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPG 480
Query: 481 YSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALI 540
YSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALI
Sbjct: 481 YSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALI 540
Query: 541 SLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK 600
SLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK
Sbjct: 541 SLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK 600
Query: 601 GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLA 660
GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLA
Sbjct: 601 GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLA 660
Query: 661 IEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVR 720
IEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVR
Sbjct: 661 IEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVR 720
Query: 721 GKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPI 780
GKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPI
Sbjct: 721 GKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPI 780
Query: 781 EIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA 840
EIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA
Sbjct: 781 EIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA 840
Query: 841 ENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILD 900
ENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILD
Sbjct: 841 ENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILD 900
Query: 901 EAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR 960
EAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR
Sbjct: 901 EAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR 960
Query: 961 KVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCK 1020
KVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCK
Sbjct: 961 KVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCK 1020
Query: 1021 QPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTV 1080
QPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTV
Sbjct: 1021 QPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTV 1080
Query: 1081 SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLS 1140
SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLS
Sbjct: 1081 SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLS 1140
Query: 1141 EEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPL 1200
EEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPL
Sbjct: 1141 EEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPL 1200
Query: 1201 HSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPS 1260
HSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPS
Sbjct: 1201 HSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPS 1260
Query: 1261 TPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLY 1320
TPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLY
Sbjct: 1261 TPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLY 1320
Query: 1321 RLPLLENAETPQ 1332
RLPLLENAETPQ
Sbjct: 1321 RLPLLENAETPQ 1332
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 1850 bits (4791), Expect = 0.0
Identities = 938/1351 (69%), Positives = 1097/1351 (81%), Gaps = 40/1351 (2%)
Query: 1 MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLC 60
MQ PYEFFSEEN+PKWRGLLV AL+KVQ QVHPTL +N+++L Y+EELI QLLN LC
Sbjct: 1 MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLC 60
Query: 61 MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY 120
AQPR+ DVEERVQK+FPHPIDKWAIADAQSAIEKRKRRNPL LPV+KIHP LKEVLGY
Sbjct: 61 QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGY 120
Query: 121 KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQD- 179
K+D+ VS+YIVAVLEYISADILKL GNYV NIRHYEI++QDIKV+MCADKVLMDMF QD
Sbjct: 121 KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV 180
Query: 180 -DIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPS 238
DI ++SL ++EPS+SGE YYDLV+ +AE RQY+RELN+IIKVFRE F+S+ KLF +
Sbjct: 181 EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSAN 240
Query: 239 DIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQ 298
D+E IFS I DIHEL+VKLLG IEDTVEMTDE SPHPL GSCFEDLAEE AFDPYE+ ++
Sbjct: 241 DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR 300
Query: 299 DILSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQL 358
DIL P FH+ F +++P AL+ QSI +GFKEAV+YVLPRL+L PVYHC HYFELLKQL
Sbjct: 301 DILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL 360
Query: 359 KACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIK 418
+ SE+QED+ECL QAITAL+N+Q M++I + +RR + C FYS Q++ K LAIK
Sbjct: 361 EEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK 420
Query: 419 KMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRL 478
KMNEIQKNIDGWEGKDIGQCCNEFIMEG LTR+GAKHERHIFLFDGLMI CK NHGQ RL
Sbjct: 421 KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL 480
Query: 479 PGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAA 538
PG S+AEYRLKEKF MRK+QI DK+DT E+KHAFE++ KDENS+IF+AKSAEEKNNWMAA
Sbjct: 481 PGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAA 540
Query: 539 LISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPI 598
LISL YRSTL+RMLD +L+EE E+ +RLPS +VYRF DSEENI+FE+N+Q ++GIPI
Sbjct: 541 LISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPI 600
Query: 599 IKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADK 658
IK GTV+KLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSL+IERFEIPEPEPT+AD+
Sbjct: 601 IKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR 660
Query: 659 LAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISS 718
+AIE G+QP+SA+LKRFRKEY+QPVQLR+LNV RHWVEHHFYDFERD LL+R+E FI +
Sbjct: 661 IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT 720
Query: 719 VRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLH 778
VRGKAMKKWVESI KII+RKK A+ NG HNITF+S PP +EWHIS+PG ETFDL+TLH
Sbjct: 721 VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH 780
Query: 779 PIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV 838
PIEIARQLTLLESDLYR VQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV
Sbjct: 781 PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV 840
Query: 839 EAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKI 898
E EN EERVAV+SRIIEILQVFQ+LNNFNGVLE+VSA+NS VYRLDHTFE + R++KI
Sbjct: 841 ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI 900
Query: 899 LDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSK 958
L+EA ELS+DH+KKYL KL+SINPPCVPFFGIYLTNILKTEEGN + LK+ GK+LINFSK
Sbjct: 901 LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK 960
Query: 959 RRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRN 1018
RRKVAEITGEIQQYQNQPYCLR+E D++RFFENLNPMG++ EKEFTDYLFNKSLEIEPRN
Sbjct: 961 RRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN 1020
Query: 1019 CKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELES 1078
K PRFP+K ++ LKSPG+RP+ R GT+R HPTPL++EP KIS+SRI E+E ES
Sbjct: 1021 PKPLPRFPKKYSYPLKSPGVRPSNPR----PGTMR-HPTPLQQEPRKISYSRIPESETES 1075
Query: 1079 TVSAPTSPNTPSTPP----VSASSDLSVFLDVDLNS--SCGSNSIFAPVLLPHS-KSFFS 1131
T SAP SP TP TPP S+++D+ D D +S ++++F V LPH +S
Sbjct: 1076 TASAPNSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASV 1135
Query: 1132 SCGSLHKLSEEPLIPPPLPPRKKFDH---DASNSKGNMKSDDDPPAIPPRQPPPPKVKPR 1188
S SL K ++E +PPP+PPR++ + ++S SK K D PPAIPPRQP PR
Sbjct: 1136 SSISLTKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPR 1195
Query: 1189 VPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDW 1248
+ D S PP P P PP P+R P+ F + P +LQPPPLG + SD
Sbjct: 1196 YSIS----DRTSISDPPESP----PLLPPREPVRTPDVFSSSPLHLQPPPLG---KKSD- 1243
Query: 1249 LRDISTCPNSPS----TPPSTPSPRVPRRCYVLS---SSQNNLAHPPAPPVPPRQNSSPH 1301
+ PNSPS PP TPSP RR ++ S + + +L PPVPPRQ++S H
Sbjct: 1244 -HGNAFFPNSPSPFTPPPPQTPSPHGTRR-HLPSPPLTQEVDLHSIAGPPVPPRQSTSQH 1301
Query: 1302 LPKLPPKTYKRELSHPPLYR--LPLLENAET 1330
+PKLPPKTYKRE +HP ++R PLLENA +
Sbjct: 1302 IPKLPPKTYKREHTHPSMHRDGPPLLENAHS 1332
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 152 bits (383), Expect = 3e-36
Identities = 104/353 (29%), Positives = 183/353 (51%), Gaps = 24/353 (6%)
Query: 671 DLKRFRKEYV--QPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRG--KAMKK 726
D + KE+V + R+LNV RHWV H DFE + EL ++ F+ V + + +
Sbjct: 920 DQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQ 979
Query: 727 WVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQL 786
++ A IIR Q + IT E E ++P FE + EIA QL
Sbjct: 980 ERKAAANIIRTLTQEDPG--DNQITLEEITQMAEGVKAEP--FENHSAL-----EIAEQL 1030
Query: 787 TLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEER 846
TLL+ +++K+ E G W K +K +P ++K +H +++ I+ E+ R
Sbjct: 1031 TLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINAR 1090
Query: 847 VAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL- 905
V+ + + + + + + L+N+N VLEI S++N +++RL T+ + ++ + ++D+ +L
Sbjct: 1091 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 1150
Query: 906 -SQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAE 964
S+ FK LK+ +PPCVP+ G+YLT++ EEG ++ + L+NFSK R ++
Sbjct: 1151 SSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTE---DGLVNFSKMRMISH 1207
Query: 965 ITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPR 1017
I EI+Q+Q Y + + + ++ L ++E L+ SL IEP+
Sbjct: 1208 IIREIRQFQQTAYKIEHQAKVTQY---LLDQSFVMDEE---SLYESSLRIEPK 1254
Score = 35.4 bits (80), Expect = 0.37
Identities = 45/204 (22%), Positives = 86/204 (42%), Gaps = 17/204 (8%)
Query: 456 ERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKE--------DTCE 507
ER FLF +I C G +L + L + ++ + + ++E D +
Sbjct: 489 ERQCFLFSKHLIICTRGSGG-KLHLTKNGVISLIDCTLLEEPESTEEEAKGSGQDIDHLD 547
Query: 508 HKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRL 567
K E ++I A S +EK W + + +D + + L+ E+ ++
Sbjct: 548 FKIGVEPKDSPPFTVILVASSRQEKAAWTSDI-----SQCVDNIRCNGLMMNAFEENSKV 602
Query: 568 PSPEVYRFVVK--DSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTF 625
P++ + + +I F + S + I + +V +L+ERLT + +F+ TF
Sbjct: 603 TVPQMIKSDASLYCDDVDIRFSKTMNSCKVLQI-RYASVERLLERLTDLRFLSIDFLNTF 661
Query: 626 LTTYRSFCKPQELLSLLIERFEIP 649
L +YR F +L LI ++ P
Sbjct: 662 LHSYRVFTTAIVVLDKLITIYKKP 685
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 152 bits (383), Expect = 3e-36
Identities = 104/353 (29%), Positives = 183/353 (51%), Gaps = 24/353 (6%)
Query: 671 DLKRFRKEYV--QPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRG--KAMKK 726
D + KE+V + R+LNV RHWV H DFE + EL ++ F+ V + + +
Sbjct: 936 DQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQ 995
Query: 727 WVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQL 786
++ A IIR Q + IT E E ++P FE + EIA QL
Sbjct: 996 ERKAAANIIRTLTQEDPG--DNQITLEEITQMAEGVKAEP--FENHSAL-----EIAEQL 1046
Query: 787 TLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEER 846
TLL+ +++K+ E G W K +K +P ++K +H +++ I+ E+ R
Sbjct: 1047 TLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINAR 1106
Query: 847 VAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL- 905
V+ + + + + + + L+N+N VLEI S++N +++RL T+ + ++ + ++D+ +L
Sbjct: 1107 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 1166
Query: 906 -SQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAE 964
S+ FK LK+ +PPCVP+ G+YLT++ EEG ++ + L+NFSK R ++
Sbjct: 1167 SSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTE---DGLVNFSKMRMISH 1223
Query: 965 ITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPR 1017
I EI+Q+Q Y + + + ++ L ++E L+ SL IEP+
Sbjct: 1224 IIREIRQFQQTAYKIEHQAKVTQY---LLDQSFVMDEE---SLYESSLRIEPK 1270
Score = 33.5 bits (75), Expect = 1.4
Identities = 46/217 (21%), Positives = 88/217 (40%), Gaps = 30/217 (13%)
Query: 456 ERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKE--------DTCE 507
ER FLF +I C G +L + L + ++ + + ++E D +
Sbjct: 489 ERQCFLFSKHLIICTRGSGG-KLHLTKNGVISLIDCTLLEEPESTEEEAKGSGQDIDHLD 547
Query: 508 HKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRL 567
K E ++I A S +EK W + + +D + + L+ E+ ++
Sbjct: 548 FKIGVEPKDSPPFTVILVASSRQEKAAWTSDI-----SQCVDNIRCNGLMMNAFEENSKV 602
Query: 568 PSPEVYRFVVKDSEE---------------NIVFEDNLQSRSGIPIIKGGTVVKLIERLT 612
P++ + + + E +I F + S + I + +V +L+ERLT
Sbjct: 603 TVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQI-RYASVERLLERLT 661
Query: 613 YHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIP 649
+ +F+ TFL +YR F +L LI ++ P
Sbjct: 662 DLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKP 698
>gi|24797101 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 2 [Homo sapiens]
Length = 489
Score = 152 bits (383), Expect = 3e-36
Identities = 104/353 (29%), Positives = 183/353 (51%), Gaps = 24/353 (6%)
Query: 671 DLKRFRKEYV--QPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRG--KAMKK 726
D + KE+V + R+LNV RHWV H DFE + EL ++ F+ V + + +
Sbjct: 152 DQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQ 211
Query: 727 WVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQL 786
++ A IIR Q + IT E E ++P FE + EIA QL
Sbjct: 212 ERKAAANIIRTLTQEDPG--DNQITLEEITQMAEGVKAEP--FENHSAL-----EIAEQL 262
Query: 787 TLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEER 846
TLL+ +++K+ E G W K +K +P ++K +H +++ I+ E+ R
Sbjct: 263 TLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINAR 322
Query: 847 VAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL- 905
V+ + + + + + + L+N+N VLEI S++N +++RL T+ + ++ + ++D+ +L
Sbjct: 323 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 382
Query: 906 -SQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAE 964
S+ FK LK+ +PPCVP+ G+YLT++ EEG ++ + L+NFSK R ++
Sbjct: 383 SSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTE---DGLVNFSKMRMISH 439
Query: 965 ITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPR 1017
I EI+Q+Q Y + + + ++ L ++E L+ SL IEP+
Sbjct: 440 IIREIRQFQQTAYKIEHQAKVTQY---LLDQSFVMDEE---SLYESSLRIEPK 486
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 147 bits (372), Expect = 5e-35
Identities = 96/342 (28%), Positives = 172/342 (50%), Gaps = 34/342 (9%)
Query: 686 RILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKA--MKKWVESIAKIIRRKKQAQA 743
R+LNV RHWV H DFE + EL + + + V + + ++ A I+R Q
Sbjct: 917 RVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRALSQDDQ 976
Query: 744 NGVSHNITFESPPPPIEWHISKPGQFETFDLM------TLHPIEIARQLTLLESDLYRKV 797
+ + H+ + D M +L +E+A Q+TLL+ ++R +
Sbjct: 977 DDI---------------HLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSI 1021
Query: 798 QPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEIL 857
E +G W K DK +P ++K +H +++ I+ + R + + + +
Sbjct: 1022 PYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVA 1081
Query: 858 QVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL--SQDHFKKYLV 915
+ + L+N+NGVLEI SA+N ++YRL T+ + ++ + ++D+ + S+ FK
Sbjct: 1082 DICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRE 1141
Query: 916 KLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQ 975
LK+ NPP VP+ G+YLT++ EEG +F + + L+NFSK R ++ I EI+Q+Q
Sbjct: 1142 TLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTE---EGLVNFSKMRMISHIIREIRQFQQT 1198
Query: 976 PYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPR 1017
Y + +P + ++ + + + D L+ SL+IEPR
Sbjct: 1199 SYRIDHQPKVAQYLLDKDLIID------EDTLYELSLKIEPR 1234
Score = 41.2 bits (95), Expect = 0.007
Identities = 33/131 (25%), Positives = 63/131 (48%), Gaps = 8/131 (6%)
Query: 521 SIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVK-- 578
+++ A S +EK WM+ + +D + + L+ E+ ++ P + + +
Sbjct: 565 TVVLLAPSRQEKAAWMSDI-----SQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLH 619
Query: 579 DSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQEL 638
+ +I F L S +P I+ +V +L+ERLT + +F+ TFL TYR F +
Sbjct: 620 KDDTDICFSKTLNSCK-VPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTAAVV 678
Query: 639 LSLLIERFEIP 649
L L + ++ P
Sbjct: 679 LGKLSDIYKRP 689
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 135 bits (341), Expect = 2e-31
Identities = 112/402 (27%), Positives = 184/402 (45%), Gaps = 55/402 (13%)
Query: 621 FVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYV 680
+ FLTTYR+F P+EL+ L R+E P D K + K
Sbjct: 733 YCEAFLTTYRTFISPEELIKKLQYRYEKFSPF-ADTFKKRVSK----------------- 774
Query: 681 QPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQ 740
N F +V D +EL E + + + + + S+A+++R+
Sbjct: 775 --------NTF--FVLVRVVDELCLVELTEEILKLLMELVFRLVCNGELSLARVLRKNIL 824
Query: 741 AQANGVSH-NITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQP 799
+ + S P ++PG F H EIA QLTLL+++L+ K++
Sbjct: 825 DKVDQKKLLRCATSSQPLAARGVAARPGTLHDF-----HSHEIAEQLTLLDAELFYKIEI 879
Query: 800 SELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQV 859
E++ +W KE E SPNL + H N++ W I+ E ++R +L + I+I++
Sbjct: 880 PEVL--LWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKH 937
Query: 860 FQDLNNFNGVLEIVSAVNSVSVYRLD---HTFEALQERKRKILDEAVELSQDHFKKYLVK 916
+ LNNFN L I+SA++S + RL+ T E L E ++D S F+ Y
Sbjct: 938 LRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAE-YCTLID-----SSSSFRAYRAA 991
Query: 917 LKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQP 976
L + PPC+P+ G+ L ++ GN D++ K +NFSKR + I ++ +Q
Sbjct: 992 LSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGK----VNFSKRWQQFNILDSMRCFQQAH 1047
Query: 977 YCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRN 1018
Y +R D+ FF + S+ + L+ SL+I+PRN
Sbjct: 1048 YDMRRNDDIINFFNDF------SDHLAEEALWELSLKIKPRN 1083
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 135 bits (341), Expect = 2e-31
Identities = 112/402 (27%), Positives = 184/402 (45%), Gaps = 55/402 (13%)
Query: 621 FVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYV 680
+ FLTTYR+F P+EL+ L R+E P D K + K
Sbjct: 715 YCEAFLTTYRTFISPEELIKKLQYRYEKFSPF-ADTFKKRVSK----------------- 756
Query: 681 QPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQ 740
N F +V D +EL E + + + + + S+A+++R+
Sbjct: 757 --------NTF--FVLVRVVDELCLVELTEEILKLLMELVFRLVCNGELSLARVLRKNIL 806
Query: 741 AQANGVSH-NITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQP 799
+ + S P ++PG F H EIA QLTLL+++L+ K++
Sbjct: 807 DKVDQKKLLRCATSSQPLAARGVAARPGTLHDF-----HSHEIAEQLTLLDAELFYKIEI 861
Query: 800 SELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQV 859
E++ +W KE E SPNL + H N++ W I+ E ++R +L + I+I++
Sbjct: 862 PEVL--LWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKH 919
Query: 860 FQDLNNFNGVLEIVSAVNSVSVYRLD---HTFEALQERKRKILDEAVELSQDHFKKYLVK 916
+ LNNFN L I+SA++S + RL+ T E L E ++D S F+ Y
Sbjct: 920 LRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAE-YCTLID-----SSSSFRAYRAA 973
Query: 917 LKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQP 976
L + PPC+P+ G+ L ++ GN D++ K +NFSKR + I ++ +Q
Sbjct: 974 LSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGK----VNFSKRWQQFNILDSMRCFQQAH 1029
Query: 977 YCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRN 1018
Y +R D+ FF + S+ + L+ SL+I+PRN
Sbjct: 1030 YDMRRNDDIINFFNDF------SDHLAEEALWELSLKIKPRN 1065
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 119 bits (299), Expect = 1e-26
Identities = 142/586 (24%), Positives = 248/586 (42%), Gaps = 90/586 (15%)
Query: 596 IPIIKGGTVVKLIERL-TYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERF-EIPEPEP 653
I IK GT+ KL+E L T D ++ FL+TYR F +E+L LL++R+ + P
Sbjct: 101 IRTIKAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPN- 159
Query: 654 TDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERD--LELLER 711
E G Q S E ++ I ++ R W++ DF L++
Sbjct: 160 ------CEEDGSQSSS--------ESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQK 205
Query: 712 LESFISSVR-GKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFE 770
L +++ + G ++ +++ + ++++ NG+ + I+F S E + +F
Sbjct: 206 LLDYLTRMMPGSDPERRAQNLLEQFQKQEVETDNGLPNTISF-SLEEEEELEGGESAEFT 264
Query: 771 TF--DLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTN 828
F DL +A QLT +++ L++KV P +G +W++ DK+ N +L IR T +
Sbjct: 265 CFSEDL-------VAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENK-HLAPTIRATIS 316
Query: 829 LTLWFEKCIVEAE------NFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVY 882
KC+V ++R ++ + I I + L NF+ + IVSA+ S S+Y
Sbjct: 317 QFNTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIY 376
Query: 883 RLDHTFEALQERKRKILDEAVELSQDH--------------------------------- 909
RL T+ A+ + + +E ++ DH
Sbjct: 377 RLKKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQ 436
Query: 910 FKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEI 969
+ L K + VP+ G +LT++ + D+++ LINF KRR+ E+ +I
Sbjct: 437 RRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIE---GGLINFEKRRREFEVIAQI 493
Query: 970 QQYQN--QPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPR 1027
+ Q+ YC+ PD ++F + +E+E Y + +E P+ PR
Sbjct: 494 KLLQSACNSYCM--TPD-QKFIQWFQRQQLLTEEE--SYALSCEIEAAADASTTSPK-PR 547
Query: 1028 KSTFS------LKSPGIRPNTGRHGSTSGTLRGHP-TPLEREPCKISFSRIAETELESTV 1080
KS L S I T T G ++ S +E E E ++
Sbjct: 548 KSMVKRLSLLFLGSDMITSPTPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAE-EGSI 606
Query: 1081 SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHS 1126
+ +P+ P +SS S +D NSS G +S+ P+ P S
Sbjct: 607 TPMDTPDEPQKKLSESSSSCSSIHSMDTNSS-GMSSLINPLSSPPS 651
>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
isoform 1 [Homo sapiens]
Length = 716
Score = 104 bits (260), Expect = 5e-22
Identities = 140/568 (24%), Positives = 225/568 (39%), Gaps = 91/568 (16%)
Query: 594 SGIPIIKGGTVVKLIERLTY-HMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPE 652
S + +++ + +L+ L + DP+F+ FL TYR+F LL L+ P P
Sbjct: 64 SKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPPPPP 123
Query: 653 PTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFE-----RDLE 707
+ K A++ DL F K +++V W++ H DF DL
Sbjct: 124 GVEIKKTAVQ--------DLS-FNKNL-----RAVVSVLGSWLQDHPQDFRDPPAHSDLG 169
Query: 708 LLERLESFISSVRGKAMK--KWVESIAKIIRRKKQAQANGVSHNITFESPP-----PPIE 760
+ + + +A K K +E + R+++ E PP PP
Sbjct: 170 SVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQE------------EEPPQVWTGPPRV 217
Query: 761 WHISKPGQFETF------------DLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWT 808
S P E L+ E+A QLTL++ +L+ KV+ E +GSVW+
Sbjct: 218 AQTSDPDSSEACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWS 277
Query: 809 KEDK---EINSPNLLKMIRHTTNLTLWFEKCIVEAENF--EERVAVLSRIIEILQVFQDL 863
+ D+ SP + + +T ++ A +R L + I I Q ++L
Sbjct: 278 QRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCREL 337
Query: 864 NNFNGVLEIVSAVNSVSVYRLDHTFEALQER--------------------KRKIL--DE 901
NF+ + I+SA+ S +YRL ++ A+ R+IL +E
Sbjct: 338 RNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEE 397
Query: 902 AVELSQDHFKKYLVKLKSINPP-CVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR 960
A E SQ+ L S PP VP+ G +LT+++ + D L+ DLINF KRR
Sbjct: 398 ATEGSQEE-DNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLE---GDLINFEKRR 453
Query: 961 KVAEITGEIQQYQN--QPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRN 1018
K EI IQQ Q Q Y L P + N + E Y ++ +E +
Sbjct: 454 KEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQL-----TEEQSYRLSRVIEPPAAS 508
Query: 1019 CKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELES 1078
C PR R+ + + K + + S SG+ +P S S +
Sbjct: 509 CPSSPRIRRRISLT-KRLSAKLAREKSSSPSGSPGDPSSPTSSLCISPSVSPGSPPSSPR 567
Query: 1079 TVSAPTSPNTPSTPPVSASSDLSVFLDV 1106
+ AP S P S+ L + LD+
Sbjct: 568 SRDAPAGSPPASPGPQGPSTKLPLSLDL 595
>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
isoform 2 [Homo sapiens]
Length = 710
Score = 104 bits (260), Expect = 5e-22
Identities = 139/560 (24%), Positives = 223/560 (39%), Gaps = 116/560 (20%)
Query: 594 SGIPIIKGGTVVKLIERLTY-HMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPE 652
S + +++ + +L+ L + DP+F+ FL TYR+F LL L+ P P
Sbjct: 64 SKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPPPPP 123
Query: 653 PTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFE-----RDLE 707
+ K A++ DL F K +++V W++ H DF DL
Sbjct: 124 GVEIKKTAVQ--------DLS-FNKNL-----RAVVSVLGSWLQDHPQDFRDPPAHSDLG 169
Query: 708 LLERLESFISSVRGKAMK--KWVESIAKIIRRKKQAQANGVSHNITFESPP-----PPIE 760
+ + + +A K K +E + R+++ E PP PP
Sbjct: 170 SVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQE------------EEPPQVWTGPPRV 217
Query: 761 WHISKPGQFETF------------DLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWT 808
S P E L+ E+A QLTL++ +L+ KV+ E +GSVW+
Sbjct: 218 AQTSDPDSSEACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWS 277
Query: 809 KEDK---EINSPNLLKMIRHTTNLTLWFEKCIVEAENF--EERVAVLSRIIEILQVFQDL 863
+ D+ SP + + +T ++ A +R L + I I Q ++L
Sbjct: 278 QRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCREL 337
Query: 864 NNFNGVLEIVSAVNSVSVYRLDHTFEALQER--------------------KRKIL--DE 901
NF+ + I+SA+ S +YRL ++ A+ R+IL +E
Sbjct: 338 RNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEE 397
Query: 902 AVELSQDHFKKYLVKLKSINPP-CVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR 960
A E SQ+ L S PP VP+ G +LT+++ + D L+ DLINF KRR
Sbjct: 398 ATEGSQEE-DNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLE---GDLINFEKRR 453
Query: 961 KVAEITGEIQQYQN--QPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRN 1018
K EI IQQ Q Q Y L P + N + E Y ++ +E +
Sbjct: 454 KEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQL-----TEEQSYRLSRVIEPPAAS 508
Query: 1019 CKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELES 1078
C PR R+ + + + + R S+S P+ +P
Sbjct: 509 CPSSPRIRRRISLTKR---LSAKLAREKSSS------PSGSPGDP--------------- 544
Query: 1079 TVSAPTSPNTPSTPPVSASS 1098
S+PTS +P +PP S S
Sbjct: 545 --SSPTSSVSPGSPPSSPRS 562
>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
[Homo sapiens]
Length = 777
Score = 102 bits (255), Expect = 2e-21
Identities = 110/473 (23%), Positives = 200/473 (42%), Gaps = 93/473 (19%)
Query: 599 IKGGTVVKLIERL--TYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDA 656
++ GT+ L+ L T D +F+ FL T+R+F LL L+ +R E E PTD
Sbjct: 92 LRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMADRLEALESHPTD- 150
Query: 657 DKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLE-LLERLESF 715
+L+R + ++V W+ H DF + + L+RLESF
Sbjct: 151 --------------ELERTTEV--------AISVLSTWLASHPEDFGSEAKGQLDRLESF 188
Query: 716 I---SSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETF 772
+ GK + + + +R + QA + + PP +
Sbjct: 189 LLQTGYAAGKGVGGGSADLIRNLRSRVDPQAPDLPKPLALPGDPPA-----------DPT 237
Query: 773 DLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINS---PNLLKMIRHTTNL 829
D++ +A QLTLL+++L+ + PS+ +G +W D+ +S P++ + +
Sbjct: 238 DVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKV 297
Query: 830 TLWFEKCIVEAENFEE--------------RVAVLSRIIEILQVFQDLNNFNGVLEIVSA 875
++ A + E R +L + I + + + L NF+ V +VSA
Sbjct: 298 AGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSA 357
Query: 876 VNSVSVYRL-----DHTFEALQ---------------ERKRKILDEAVELS---QDHFKK 912
+ S ++RL + T ++L+ + R++L + V+L + H KK
Sbjct: 358 LQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKK 417
Query: 913 YLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQY 972
+ S VP+ G +L +++ + + D L+ INF KRRK + E+++
Sbjct: 418 -APRSGSRGGGVVPYLGTFLKDLVMLDAASKDELE---NGYINFDKRRKEFAVLSELRRL 473
Query: 973 QNQ--PYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPP 1023
QN+ Y L+ + D++R+ + L P+ A S E+EP PP
Sbjct: 474 QNECRGYNLQPDHDIQRWLQGLRPLTEAQSHRV-------SCEVEPPGSSDPP 519
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 102 bits (253), Expect = 3e-21
Identities = 78/298 (26%), Positives = 140/298 (46%), Gaps = 17/298 (5%)
Query: 772 FDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTL 831
FD++ + P E A Q+TL++ +++ +QP EL W K++K ++PN + R +++
Sbjct: 43 FDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSF 102
Query: 832 WFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEAL 891
W + I+ A+ + R VLS I+ + +LNN + ++ +VS + S ++RL T+ AL
Sbjct: 103 WVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTW-AL 161
Query: 892 QERKRKILDEAVEL---SQDHFKK---YLVKLKSINPPCVPFFGIYLTNILKTEEGNNDF 945
RK K E +E +D++K+ Y+ LK PC+P+ GIYL+++ +
Sbjct: 162 LSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKM--TPCIPYLGIYLSDLTYIDSA---- 215
Query: 946 LKKKGKDLINFSKRRKVAEITGEIQQYQNQ-PYCLRIEPDMRRFFENLNPMGSASEKEFT 1004
G L N + + I I Q Y + + P ++++ ++ + +K
Sbjct: 216 YPSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYI-EELQKFVE 274
Query: 1005 DYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHG-STSGTLRGHPTPLER 1061
D + SL+IEP P + G P +GR + G L P R
Sbjct: 275 DDNYKLSLKIEP-GTSTPRSAASREDLVGPEVGASPQSGRKSVAAEGALLPQTPPSPR 331
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 101 bits (251), Expect = 5e-21
Identities = 79/336 (23%), Positives = 161/336 (47%), Gaps = 25/336 (7%)
Query: 762 HISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLK 821
+ SK FD++ + P E A Q+TL++ +++ +QP EL W+K++K +PN++
Sbjct: 34 YASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVA 93
Query: 822 MIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSV 881
R ++ W + I+ A+ + R +LS ++I + +LNN + ++ +VSA+ S +
Sbjct: 94 FTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPI 153
Query: 882 YRLDHTFEALQERKRKILDEAVEL---SQDHFKK---YLVKLKSINPPCVPFFGIYLTNI 935
+RL T+ AL RK K E ++ +D++K+ Y+ LK + P +P+ GIYL ++
Sbjct: 154 FRLTKTW-ALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMV--PSIPYLGIYLLDL 210
Query: 936 LKTEE---GNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENL 992
+ + + ++ + + ++ + I ++Q + + L P ++++ +++
Sbjct: 211 IYIDSAYPASGSIMENEQRS----NQMNNILRIIADLQVSCSYDH-LTTLPHVQKYLKSV 265
Query: 993 NPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPG------IRPNTGRHG 1046
+ +K D + SL IEP P K + S G R T
Sbjct: 266 RYI-EELQKFVEDDNYKLSLRIEP-GSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDT 323
Query: 1047 STSGTLRGHPTPLEREPCKISFSRIAETELESTVSA 1082
S +G+L P P R+ + + + + + + SA
Sbjct: 324 SVAGSLPTPPVPRHRKSHSLGNNMMCQLSVVESKSA 359
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 90.5 bits (223), Expect = 1e-17
Identities = 65/251 (25%), Positives = 119/251 (47%), Gaps = 16/251 (6%)
Query: 752 FESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKED 811
F+S P E G TF+LM+ ++A Q+T+ + +L+ V EL+ + + +
Sbjct: 604 FDSLTPLPEQEGPTVGTVGTFELMSSK--DLAYQMTIYDWELFNCVHELELIYHTFGRHN 661
Query: 812 KEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLE 871
+ + NL +R + W I +RV +L + I+I ++ N N
Sbjct: 662 FKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 721
Query: 872 IVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL---SQDHFKKYLVKLKSINPPCVPFF 928
IV +++V+V RL T+E L + +K E L S++H + Y + + + PP +PF
Sbjct: 722 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNH-RAYRLTVAKLEPPLIPFM 780
Query: 929 GIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPY------CLRIE 982
+ + ++ T EGN F+ +L+NF K R +A ++ Y++QP+ +
Sbjct: 781 PLLIKDMTFTHEGNKTFI----DNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNH 836
Query: 983 PDMRRFFENLN 993
D+R + LN
Sbjct: 837 QDVRSYVRQLN 847
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform
a [Homo sapiens]
Length = 1011
Score = 90.5 bits (223), Expect = 1e-17
Identities = 65/251 (25%), Positives = 119/251 (47%), Gaps = 16/251 (6%)
Query: 752 FESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKED 811
F+S P E G TF+LM+ ++A Q+T+ + +L+ V EL+ + + +
Sbjct: 748 FDSLTPLPEQEGPTVGTVGTFELMSSK--DLAYQMTIYDWELFNCVHELELIYHTFGRHN 805
Query: 812 KEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLE 871
+ + NL +R + W I +RV +L + I+I ++ N N
Sbjct: 806 FKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 865
Query: 872 IVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL---SQDHFKKYLVKLKSINPPCVPFF 928
IV +++V+V RL T+E L + +K E L S++H + Y + + + PP +PF
Sbjct: 866 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNH-RAYRLTVAKLEPPLIPFM 924
Query: 929 GIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPY------CLRIE 982
+ + ++ T EGN F+ +L+NF K R +A ++ Y++QP+ +
Sbjct: 925 PLLIKDMTFTHEGNKTFI----DNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNH 980
Query: 983 PDMRRFFENLN 993
D+R + LN
Sbjct: 981 QDVRSYVRQLN 991
>gi|24307909 ral guanine nucleotide dissociation stimulator isoform 1
[Homo sapiens]
Length = 914
Score = 87.8 bits (216), Expect = 6e-17
Identities = 72/275 (26%), Positives = 124/275 (45%), Gaps = 41/275 (14%)
Query: 774 LMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWF 833
L+ P +A Q TL++++L++KV P +GS+W++ DK+ +L IR T
Sbjct: 382 LLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKK-GKEHLAPTIRATVTQFNSV 440
Query: 834 EKCIV------EAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHT 887
C++ + +R V+ IE+ + + L NF+ + I+SA+ S S++RL T
Sbjct: 441 ANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKT 500
Query: 888 FEALQERKRKILDEAVELSQDH-----FKKYLVK-------LKSINPP------------ 923
+E + +I + E+ D ++ L+K +NP
Sbjct: 501 WEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGII 560
Query: 924 --CVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRI 981
VP+ G +LT+++ + D+L + LINF KRRK E+ +I+ Q+ I
Sbjct: 561 QGTVPYLGTFLTDLVMLDTAMKDYLYGR---LINFEKRRKEFEVIAQIKLLQSACNNYSI 617
Query: 982 EPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEP 1016
PD E A E+ +N S E+EP
Sbjct: 618 APD-----EQFGAWFRAVERLSETESYNLSCELEP 647
Score = 41.2 bits (95), Expect = 0.007
Identities = 22/59 (37%), Positives = 34/59 (57%), Gaps = 1/59 (1%)
Query: 589 NLQSRSGIPIIKGGTVVKLIERLTYHMY-ADPNFVRTFLTTYRSFCKPQELLSLLIERF 646
NL + +K GT+ KL+E L +D ++V FL TYR+F Q++L LL +R+
Sbjct: 106 NLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRY 164
>gi|108796058 ral guanine nucleotide dissociation stimulator isoform 2
[Homo sapiens]
Length = 859
Score = 87.8 bits (216), Expect = 6e-17
Identities = 72/275 (26%), Positives = 124/275 (45%), Gaps = 41/275 (14%)
Query: 774 LMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWF 833
L+ P +A Q TL++++L++KV P +GS+W++ DK+ +L IR T
Sbjct: 327 LLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKK-GKEHLAPTIRATVTQFNSV 385
Query: 834 EKCIV------EAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHT 887
C++ + +R V+ IE+ + + L NF+ + I+SA+ S S++RL T
Sbjct: 386 ANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKT 445
Query: 888 FEALQERKRKILDEAVELSQDH-----FKKYLVK-------LKSINPP------------ 923
+E + +I + E+ D ++ L+K +NP
Sbjct: 446 WEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGII 505
Query: 924 --CVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRI 981
VP+ G +LT+++ + D+L + LINF KRRK E+ +I+ Q+ I
Sbjct: 506 QGTVPYLGTFLTDLVMLDTAMKDYLYGR---LINFEKRRKEFEVIAQIKLLQSACNNYSI 562
Query: 982 EPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEP 1016
PD E A E+ +N S E+EP
Sbjct: 563 APD-----EQFGAWFRAVERLSETESYNLSCELEP 592
Score = 41.2 bits (95), Expect = 0.007
Identities = 22/59 (37%), Positives = 34/59 (57%), Gaps = 1/59 (1%)
Query: 589 NLQSRSGIPIIKGGTVVKLIERLTYHMY-ADPNFVRTFLTTYRSFCKPQELLSLLIERF 646
NL + +K GT+ KL+E L +D ++V FL TYR+F Q++L LL +R+
Sbjct: 51 NLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRY 109
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 81.3 bits (199), Expect = 6e-15
Identities = 88/366 (24%), Positives = 155/366 (42%), Gaps = 50/366 (13%)
Query: 186 LCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFS 245
LC P + + +++ ++ ER Y++ L I + + + R +F ++ IF
Sbjct: 91 LCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFG 150
Query: 246 NISDIHELTVKLLGLIEDTVEMTDESSPH-PLAGSCFEDLAEEQAFDPYETLSQDILSPE 304
NI DI+ +G + D + + PH G CF L + F Y + L +
Sbjct: 151 NIEDIYRFQ---MGFVRDLEKQYNNDDPHLSEIGPCF--LEHQDGFWIYSEYCNNHL--D 203
Query: 305 FHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYH-CWHYFELLKQLKACSE 363
+KLM + + HF ++ + + +L PV C + +L + LK ++
Sbjct: 204 ACMELSKLM-KDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQ 262
Query: 364 EQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEI 423
+ D + A+ + N + +Q + R+R +L + I K+ +
Sbjct: 263 DHSDYRYVAAALAVMRN-------VTQQINERKR-----------RLEN----IDKIAQW 300
Query: 424 QKNIDGWEGKDIGQCCNEFIMEGPLTRI----GAKHERHIFLFDGLMISCKPNHGQTRLP 479
Q ++ WEG+DI +E I G + I G +R FLFD M+ CK + + +
Sbjct: 301 QASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDIL 360
Query: 480 GYSSAEYRLKEKFVMRKIQICDKED------TCEHKHAFELVSKDENSI-IFAAKSAEEK 532
Y K + M K ++ D ED K+AF+L +K+ I +F AK EEK
Sbjct: 361 YY-------KGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEK 413
Query: 533 NNWMAA 538
W+ A
Sbjct: 414 IRWLRA 419
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 81.3 bits (199), Expect = 6e-15
Identities = 92/373 (24%), Positives = 158/373 (42%), Gaps = 39/373 (10%)
Query: 201 DLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNISDIHELTVKLLGL 260
+++R + ER Y++ L I + + +F + + IF NI DI++ K L
Sbjct: 243 NVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFL-- 300
Query: 261 IEDTVEMTDESSPH-PLAGSCFEDLAEEQAFDPYETLSQDILSPEFHEHFNKLMARPAVA 319
+D + ++ PH GSCF L ++ F Y + P LM +
Sbjct: 301 -KDLEKQYNKEEPHLSEIGSCF--LQNQEGFAIYSEYCNN--HPGACLELANLMKQGKYR 355
Query: 320 LHFQSIADGFKEAVRYVLPRLMLVPVYH-CWHYFELLKQLKACSEEQEDRECLNQAITAL 378
HF ++ + + +L PV C + +L + LK ++E D + A A+
Sbjct: 356 -HFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAM 414
Query: 379 MNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQC 438
N+ ++ R+R K +I K+ Q +I GWEG DI
Sbjct: 415 KNVACLINE-------RKR---------------KLESIDKIARWQVSIVGWEGLDILDR 452
Query: 439 CNEFIMEGPLTRI---GAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMR 495
+E I G LT+I G +R FLFD ++SCK + + + Y + E ++
Sbjct: 453 SSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLLRRDML-YYKGRLDMDEMELVD 511
Query: 496 KIQICDKEDTCEHKHAFELVSKDENSI-IFAAKSAEEKNNWMAALISLHYRSTLDRMLDS 554
DK+ K+AF+LVS+ + + +F AK E+K W+ A R D+ +
Sbjct: 512 LGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQACADERRRVQEDKEMGM 571
Query: 555 VLLKEENEQPLRL 567
+ EN++ L +
Sbjct: 572 EI--SENQKKLAM 582
>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
I [Homo sapiens]
Length = 1601
Score = 80.5 bits (197), Expect = 1e-14
Identities = 57/203 (28%), Positives = 102/203 (50%), Gaps = 14/203 (6%)
Query: 774 LMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNL-TLW 832
++ L IE+A QL++ + DL+R ++P+E + ++ K N+ LK N T W
Sbjct: 856 MLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTH--LKRFEDIVNQETFW 913
Query: 833 FEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQ 892
I+ N +R+ ++ I+I ++ NFN + I+S +N SV RL T+E L
Sbjct: 914 VASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLP 973
Query: 893 ERKRKILDEAVEL--SQDHFKKY--LVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKK 948
+ K L + ++ + KY ++ +S+ PP +P F + ++ EGN+
Sbjct: 974 SKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGND----S 1029
Query: 949 KGKDLINFSKRRKVAEITGEIQQ 971
K L+NF K R +++ EI+Q
Sbjct: 1030 KVDGLVNFEKLRMISK---EIRQ 1049
Score = 41.2 bits (95), Expect = 0.007
Identities = 38/155 (24%), Positives = 58/155 (37%), Gaps = 39/155 (25%)
Query: 576 VVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLI-ERLTYHMY-----ADPNFVRTFLTTY 629
V ++ E +V E RSG KG V+K ERL H+ DP ++ FL TY
Sbjct: 390 VEEEGEIVMVHEHRELDRSGTR--KGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTY 447
Query: 630 RSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILN 689
R+F E P+ +K + ++ ++
Sbjct: 448 RTFL-------------------------------ESPLDVGIKLLEWFKIDSLRDKVTR 476
Query: 690 VFRHWVEHHFYDFERDLELLERLESFISSVRGKAM 724
+ WV +HF DFE D + LE F ++ M
Sbjct: 477 IVLLWVNNHFNDFEGDPAMTRFLEEFEKNLEDTKM 511
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 78.6 bits (192), Expect = 4e-14
Identities = 50/195 (25%), Positives = 95/195 (48%), Gaps = 9/195 (4%)
Query: 774 LMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWF 833
L+ L +E+A QL++ +L+R ++P+E + ++ K + NL + T W
Sbjct: 713 LLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKT-SCANLKRFEEVINQETFWV 771
Query: 834 EKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQE 893
I+ N +R+ ++ I+I ++ NFN + I+S +N V RL T+E L
Sbjct: 772 ASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPN 831
Query: 894 RKRKILDEAVEL--SQDHFKKY--LVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKK 949
+ K+ + +L + KY ++ +++ PP +P F + ++ EGN+ K
Sbjct: 832 KYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGND----SK 887
Query: 950 GKDLINFSKRRKVAE 964
L+NF K R +A+
Sbjct: 888 VDGLVNFEKLRMIAK 902
Score = 45.4 bits (106), Expect = 4e-04
Identities = 37/138 (26%), Positives = 55/138 (39%), Gaps = 33/138 (23%)
Query: 588 DNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCK-PQELLSLLIERF 646
D +R G +IKG + + + H DP F+ FL TYR+F P E+ L+E F
Sbjct: 261 DRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWF 320
Query: 647 EIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDL 706
+P+ DK + V WV +HF DFE D
Sbjct: 321 N----DPSLRDK----------------------------VTRVVLLWVNNHFNDFEGDP 348
Query: 707 ELLERLESFISSVRGKAM 724
+ LE F +++ + M
Sbjct: 349 AMTRFLEEFENNLEREKM 366
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 78.2 bits (191), Expect = 5e-14
Identities = 58/265 (21%), Positives = 115/265 (43%), Gaps = 27/265 (10%)
Query: 764 SKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMI 823
++ Q + ++ ++ ++A +L + L+ + EL+ ++++ ++ NL ++
Sbjct: 481 NEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLL 540
Query: 824 RHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYR 883
+ + LW I+ +RV ++ + I+I + N N IV +N+ SV R
Sbjct: 541 QRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSR 600
Query: 884 LDHTFEALQERKRKILDEAVELSQD--HFKKYLVKLKSINPPCVPFFGIYLTNILKTEEG 941
L T+E + + +K+ E L+ + K Y K + PP +PF + L ++ EG
Sbjct: 601 LSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEG 660
Query: 942 NNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEK 1001
N FL +L+NF K +A+ ++ + F +L+P K
Sbjct: 661 NKTFL----DNLVNFEKLHMIADTVRTLRHCRTNQ------------FGDLSPKEHQELK 704
Query: 1002 EFTDY---------LFNKSLEIEPR 1017
+ ++ LF S IEPR
Sbjct: 705 SYVNHLYVIDSQQALFELSHRIEPR 729
>gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
isoform 2 [Homo sapiens]
Length = 689
Score = 75.9 bits (185), Expect = 2e-13
Identities = 85/375 (22%), Positives = 156/375 (41%), Gaps = 54/375 (14%)
Query: 684 QLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESI-----------A 732
+L+I R+W+ +F DL L+ E F +K V I
Sbjct: 71 RLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMR 130
Query: 733 KIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQF-ETFDLMTLHPIEIARQLTLLES 791
++ +RKK +SK G+ FD L PIE+A LT LE
Sbjct: 131 RVTQRKK-----------------------VSKKGKACLLFD--HLEPIELAEHLTFLEH 165
Query: 792 DLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLS 851
+R++ ++ V N+P L + I ++ W + ++ ++R V++
Sbjct: 166 KSFRRISFTDYQSYVI--HGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVIT 223
Query: 852 RIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL--SQDH 909
+ I + + L NFN ++ +V ++ S+ RL T L K +E EL S +
Sbjct: 224 KFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGN 283
Query: 910 FKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEI 969
+ Y + +P G++L +++ D+ + ++ +N K +++ E+
Sbjct: 284 YCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTE---ENKVNIVKMHQLSVTLSEL 340
Query: 970 QQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFT-DYLFNKSLEIEPRNCKQP--PRFP 1026
QN + +EP+M + +N + + + T D ++ SL +EPRN K P P P
Sbjct: 341 VSLQNASH--HLEPNM----DLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSPTSPTTP 394
Query: 1027 RKSTFSLK-SPGIRP 1040
K L+ + G+ P
Sbjct: 395 NKPVVPLEWALGVMP 409
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapiens]
Length = 797
Score = 75.5 bits (184), Expect = 3e-13
Identities = 79/348 (22%), Positives = 145/348 (41%), Gaps = 27/348 (7%)
Query: 685 LRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQAN 744
L+I R+W+ + F+ D L + +E F V+ K E + + Q A
Sbjct: 123 LKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKG-----EELHCRLIDTTQINAR 177
Query: 745 GVSHNITFESPPPPIEWHISKPGQFET-FDLMTLHPIEIARQLTLLESDLYRKVQPSELV 803
S +T I+ + SK + FD L P E++ LT LE +R++ S+
Sbjct: 178 DWSRKLTQR-----IKSNTSKKRKVSLLFD--HLEPEELSEHLTYLEFKSFRRISFSDYQ 230
Query: 804 GSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDL 863
+ KE +P + + I ++ W + ++ + R V + I++ Q L
Sbjct: 231 NYLVNSCVKE--NPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQL 288
Query: 864 NNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL--SQDHFKKYLVKLKSIN 921
NFN ++ ++ + S+ RL T + K+L E EL S ++ Y
Sbjct: 289 QNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECT 348
Query: 922 PPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRI 981
+P G++L +++ E D+L + GK +N K + E+ Q Q +
Sbjct: 349 DFKIPILGVHLKDLISLYEAMPDYL-EDGK--VNVHKLLALYNHISELVQLQ------EV 399
Query: 982 EPDMRRFFENLNPMGSASEKEFT-DYLFNKSLEIEPRNCKQPPRFPRK 1028
P + + ++ + + + +T D ++ S EPRN + PP P K
Sbjct: 400 APPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSK 447
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 74.7 bits (182), Expect = 5e-13
Identities = 80/358 (22%), Positives = 148/358 (41%), Gaps = 51/358 (14%)
Query: 684 QLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESI-----------A 732
+L+I R+W+ +F DL L+ E F +K V I
Sbjct: 71 RLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMR 130
Query: 733 KIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQF-ETFDLMTLHPIEIARQLTLLES 791
++ +RKK +SK G+ FD L PIE+A LT LE
Sbjct: 131 RVTQRKK-----------------------VSKKGKACLLFD--HLEPIELAEHLTFLEH 165
Query: 792 DLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLS 851
+R++ ++ V N+P L + I ++ W + ++ ++R V++
Sbjct: 166 KSFRRISFTDYQSYVI--HGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVIT 223
Query: 852 RIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL--SQDH 909
+ I + + L NFN ++ +V ++ S+ RL T L K +E EL S +
Sbjct: 224 KFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGN 283
Query: 910 FKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEI 969
+ Y + +P G++L +++ D+ + ++ +N K +++ E+
Sbjct: 284 YCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTE---ENKVNIVKMHQLSVTLSEL 340
Query: 970 QQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFT-DYLFNKSLEIEPRNCKQPPRFP 1026
QN + +EP+M + +N + + + T D ++ SL +EPRN K P P
Sbjct: 341 VSLQNASH--HLEPNM----DLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSP 392
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 74.7 bits (182), Expect = 5e-13
Identities = 80/358 (22%), Positives = 148/358 (41%), Gaps = 51/358 (14%)
Query: 684 QLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESI-----------A 732
+L+I R+W+ +F DL L+ E F +K V I
Sbjct: 71 RLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMR 130
Query: 733 KIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQF-ETFDLMTLHPIEIARQLTLLES 791
++ +RKK +SK G+ FD L PIE+A LT LE
Sbjct: 131 RVTQRKK-----------------------VSKKGKACLLFD--HLEPIELAEHLTFLEH 165
Query: 792 DLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLS 851
+R++ ++ V N+P L + I ++ W + ++ ++R V++
Sbjct: 166 KSFRRISFTDYQSYVI--HGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVIT 223
Query: 852 RIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL--SQDH 909
+ I + + L NFN ++ +V ++ S+ RL T L K +E EL S +
Sbjct: 224 KFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGN 283
Query: 910 FKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEI 969
+ Y + +P G++L +++ D+ + ++ +N K +++ E+
Sbjct: 284 YCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTE---ENKVNIVKMHQLSVTLSEL 340
Query: 970 QQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFT-DYLFNKSLEIEPRNCKQPPRFP 1026
QN + +EP+M + +N + + + T D ++ SL +EPRN K P P
Sbjct: 341 VSLQNASH--HLEPNM----DLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSP 392
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1
[Homo sapiens]
Length = 456
Score = 73.2 bits (178), Expect = 2e-12
Identities = 56/229 (24%), Positives = 106/229 (46%), Gaps = 10/229 (4%)
Query: 756 PPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEIN 815
P P E +S PG E + + P ++A LT +L+R V E V V+ E
Sbjct: 200 PLPEEIQVS-PGDTE---IHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRE 255
Query: 816 SPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSA 875
+ NL +++ + +T W ++ E +R +L + I+I + + + +V
Sbjct: 256 TANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMG 315
Query: 876 VNSVSVYRLDHTFEALQERKRKILDEAVELSQD--HFKKYLVKLKSINPPCVPFFGIYLT 933
+++ +V RL T+E L + + + + L+ + K Y + + PP +PF + L
Sbjct: 316 LDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILK 375
Query: 934 NILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIE 982
++ EG+ + L+N K VAE I++Y+++P CL +E
Sbjct: 376 DLTFLHEGSKTLV----DGLVNIEKLHSVAEKVRTIRKYRSRPLCLDME 420
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 72.4 bits (176), Expect = 3e-12
Identities = 95/404 (23%), Positives = 174/404 (43%), Gaps = 60/404 (14%)
Query: 602 GTVVKLIERLTYHM--YADPNFVRTFLTTYRSFCKPQELLS----LLIERFEIPEPEPTD 655
G++ LI+ L ++ Y D ++ TFL + R F P EL++ L +E + +P D
Sbjct: 41 GSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDP---D 97
Query: 656 ADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDF--ERDLELLERLE 713
+DK + K + +IL + W E YDF ER + L+ L
Sbjct: 98 SDKNQMRK-------------------IAPKILQLLTEWTETFPYDFRDERMMRNLKDLA 138
Query: 714 SFISSVRGKAMKKWVESIAKIIRRKKQA--QANGVSHNITFESPPPPIEWHISKPGQFET 771
I+S + +K V+ + + + RK A Q V I+ S + +KP +
Sbjct: 139 HRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTSTDR-LTVLKTKPQSIQR 197
Query: 772 FDLMTL--HPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNL 829
D++T+ P +A+QLT +E + + P E V + ++D N + + T NL
Sbjct: 198 -DIITVCNDPYTLAQQLTHIELERLNYIGPEEFV-QAFVQKDPLDNDKSCYSERKKTRNL 255
Query: 830 TL---WFEKC--IVEAE-----NFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSV 879
WF + +V E + R ++ I++ + ++ NFN ++ I+S +N
Sbjct: 256 EAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMS 315
Query: 880 SVYRLDHTFEALQERKRKILDEAVELSQDHF----------KKYLVKLKSINPPCVPFFG 929
V RL T+ ++ K IL+ ++ S + + ++ L S +PFF
Sbjct: 316 PVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFS 375
Query: 930 IYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQ 973
+ + +I EG + L +NF K ++A+ E ++
Sbjct: 376 LLIKDIYFLNEGCANRLP---NGHVNFEKFWELAKQVSEFMTWK 416
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 71.6 bits (174), Expect = 5e-12
Identities = 88/407 (21%), Positives = 168/407 (41%), Gaps = 61/407 (14%)
Query: 593 RSGIPIIKGGTVVKLIERLTYHM------YADPNFVRTFLTTYRSFCKPQELLS----LL 642
++G P++ G +E L H+ Y + ++ TFL + R F +P+ELL+ L
Sbjct: 28 QAGQPLLDGAPSSASLETLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPRELLARVCHLC 87
Query: 643 IERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDF 702
IE+ ++ DK ++K A +++F ++L + W E DF
Sbjct: 88 IEQQQL--------DKPVLDK------ARVRKFGP--------KLLQLLAEWTETFPRDF 125
Query: 703 ERDLELLERLESFISSVR--GKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIE 760
+ + + L+ + + +A +K + + + + +K A G + + P I
Sbjct: 126 QEE-STIGHLKDVVGRIAPCDEAYRKRMHQLLQALHQKLAALRQGPEGLVGADKP---IS 181
Query: 761 WHISKPGQFETFDL-MTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNL 819
+ P L + P +A+QLT +E + R + P E V + K+ P
Sbjct: 182 YRTKPPASIHRELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCF 241
Query: 820 LKMIRHTTNLTLWFEK-CIVEAENF------EERVAVLSRIIEILQVFQDLNNFNGVLEI 872
+ WF + C + A ++R V+ I++ + ++ NFN ++ I
Sbjct: 242 SDKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAI 301
Query: 873 VSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLK-----------SIN 921
+S +N V RL T+ ++ K IL+ ++ +F Y L+ S
Sbjct: 302 ISGMNMSPVSRLKKTWAKVRTAKFFILEHQMD-PTGNFCNYRTALRGAAHRSLTAHSSRE 360
Query: 922 PPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGE 968
+PFF + + +I EG + L +NF K ++A+ GE
Sbjct: 361 KIVIPFFSLLIKDIYFLNEGCANRLP---NGHVNFEKFLELAKQVGE 404
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,466,963
Number of Sequences: 37866
Number of extensions: 3545620
Number of successful extensions: 41506
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 437
Number of HSP's successfully gapped in prelim test: 1046
Number of HSP's that attempted gapping in prelim test: 20031
Number of HSP's gapped (non-prelim): 10059
length of query: 1332
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1218
effective length of database: 13,930,794
effective search space: 16967707092
effective search space used: 16967707092
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.