Search of human proteins with 15451940

Search of human proteins with 15451940

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
sapiens]
         (437 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   910   0.0  
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   893   0.0  
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         263   3e-70
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   252   5e-67
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   252   5e-67
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   243   2e-64
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          220   2e-57
gi|33695155 hepsin [Homo sapiens]                                     219   4e-57
gi|4504481 hepsin [Homo sapiens]                                      219   4e-57
gi|223942069 enterokinase precursor [Homo sapiens]                    215   7e-56
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          209   4e-54
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           194   1e-49
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             188   7e-48
gi|194018492 transmembrane protease, serine 11F [Homo sapiens]        187   2e-47
gi|187761337 transmembrane protease, serine 11B [Homo sapiens]        187   2e-47
gi|148613878 acrosin precursor [Homo sapiens]                         185   8e-47
gi|40254871 transmembrane protease, serine 11E [Homo sapiens]         184   2e-46
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]       184   2e-46
gi|117956391 protease, serine, 33 [Homo sapiens]                      183   3e-46
gi|205360905 testis-specific serine protease 1 [Homo sapiens]         182   4e-46
gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]      182   4e-46
gi|5803197 testisin isoform 1 [Homo sapiens]                          182   7e-46
gi|21614531 testisin isoform 2 [Homo sapiens]                         180   3e-45
gi|13994276 marapsin [Homo sapiens]                                   179   4e-45
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           178   8e-45
gi|11545839 protease, serine, 22 [Homo sapiens]                       178   8e-45
gi|29244926 corin [Homo sapiens]                                      175   6e-44
gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ...   174   2e-43
gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo ...   174   2e-43
gi|222831592 transmembrane protease, serine 7 [Homo sapiens]          172   4e-43

>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
           sapiens]
          Length = 437

 Score =  910 bits (2351), Expect = 0.0
 Identities = 437/437 (100%), Positives = 437/437 (100%)

Query: 1   MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKY 60
           MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKY
Sbjct: 1   MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKY 60

Query: 61  YFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSAT 120
           YFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSAT
Sbjct: 61  YFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSAT 120

Query: 121 GNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSS 180
           GNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSS
Sbjct: 121 GNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSS 180

Query: 181 GPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWV 240
           GPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWV
Sbjct: 181 GPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWV 240

Query: 241 LTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPL 300
           LTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPL
Sbjct: 241 LTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPL 300

Query: 301 TFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADD 360
           TFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADD
Sbjct: 301 TFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADD 360

Query: 361 AYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYT 420
           AYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYT
Sbjct: 361 AYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYT 420

Query: 421 KVSAYLNWIYNVWKAEL 437
           KVSAYLNWIYNVWKAEL
Sbjct: 421 KVSAYLNWIYNVWKAEL 437


>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
           sapiens]
          Length = 432

 Score =  893 bits (2308), Expect = 0.0
 Identities = 432/437 (98%), Positives = 432/437 (98%), Gaps = 5/437 (1%)

Query: 1   MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKY 60
           MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKY
Sbjct: 1   MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKY 60

Query: 61  YFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSAT 120
           YFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSAT
Sbjct: 61  YFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSAT 120

Query: 121 GNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSS 180
           GNWFSACFDNFTEALAETACRQMGYS     RAVEIGPDQDLDVVEITENSQELRMRNSS
Sbjct: 121 GNWFSACFDNFTEALAETACRQMGYS-----RAVEIGPDQDLDVVEITENSQELRMRNSS 175

Query: 181 GPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWV 240
           GPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWV
Sbjct: 176 GPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWV 235

Query: 241 LTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPL 300
           LTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPL
Sbjct: 236 LTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPL 295

Query: 301 TFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADD 360
           TFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADD
Sbjct: 296 TFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADD 355

Query: 361 AYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYT 420
           AYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYT
Sbjct: 356 AYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYT 415

Query: 421 KVSAYLNWIYNVWKAEL 437
           KVSAYLNWIYNVWKAEL
Sbjct: 416 KVSAYLNWIYNVWKAEL 432


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  263 bits (671), Expect = 3e-70
 Identities = 146/410 (35%), Positives = 215/410 (52%), Gaps = 19/410 (4%)

Query: 34  IPII-IALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQL-CDGELDCPLGEDEEH 91
           +P+I   LL +A ++ +++L +           +     P+  + CDG +DC L  DE  
Sbjct: 166 LPLIGCVLLLIALVVSLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELG 225

Query: 92  CVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTF 151
           CV           R   D+S L++   ++  W   C  N+ ++ +E  C+Q+G+ S    
Sbjct: 226 CV-----------RFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFES--AH 272

Query: 152 RAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGGEEA 211
           R  E+      +   I   +  ++       C S   +SL C  CG    T R+VGG  A
Sbjct: 273 RTTEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAMTGRIVGGALA 332

Query: 212 SVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCF--RKHTDVFNWKVRAGSDKLGSFP 269
           S   WPWQVS+ +   H+CGG+++D  WVLTAAHCF   +   +  WKV AG+  L   P
Sbjct: 333 SDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLP 392

Query: 270 SLAVAKIIIIEFNPMYPKDN-DIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIG 328
             A    III  N    +D+ DIALM+L  PLT S  + P CLP   +  +     WI G
Sbjct: 393 EAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITG 452

Query: 329 WGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSG 388
           +G T++   K S  L +  V +ID  +CN    Y   +T +MMCAG   GG D+CQGDSG
Sbjct: 453 FGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSG 512

Query: 389 GPLM-YQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL 437
           GPL+  Q+++W++ G+ SWG GCG  + PGVYTKV+  L WIY+  ++E+
Sbjct: 513 GPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEV 562


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  252 bits (643), Expect = 5e-67
 Identities = 146/380 (38%), Positives = 205/380 (53%), Gaps = 41/380 (10%)

Query: 77  CDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALA 136
           CDG   CP GEDE  CV+ +  GP            LQV  S   +W   C D++ E   
Sbjct: 170 CDGVSHCPGGEDENRCVRLY--GP---------NFILQVYSSQRKSWHPVCQDDWNENYG 218

Query: 137 ETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSG------------PCL 184
             ACR MGY  K  F + +        +V+ + ++  +++  S+G             C 
Sbjct: 219 RAACRDMGY--KNNFYSSQ-------GIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACS 269

Query: 185 SGSLVSLHCLACGKSLKTPR---VVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVL 241
           S ++VSL C+ACG +L + R   +VGGE A   +WPWQVS+     HVCGGSI+ P W++
Sbjct: 270 SKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIV 329

Query: 242 TAAHCFRKH-TDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMY---PKDNDIALMKLQ 297
           TAAHC  K   + ++W   AG  +       A  ++  +  +P Y    K+NDIALMKLQ
Sbjct: 330 TAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQ 389

Query: 298 FPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCN 357
            PLTF+  V+P+CLP     L P    WI GWG T++  GK S++L  A V +I++ RCN
Sbjct: 390 KPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK-GKTSEVLNAAKVLLIETQRCN 448

Query: 358 ADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQ-WHVVGIVSWGYGCGGPSTP 416
           +   Y   +T  M+CAG  +G VD+CQGDSGGPL+   +  W ++G  SWG GC     P
Sbjct: 449 SRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRP 508

Query: 417 GVYTKVSAYLNWIYNVWKAE 436
           GVY  V  + +WIY   +A+
Sbjct: 509 GVYGNVMVFTDWIYRQMRAD 528


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  252 bits (643), Expect = 5e-67
 Identities = 146/380 (38%), Positives = 205/380 (53%), Gaps = 41/380 (10%)

Query: 77  CDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALA 136
           CDG   CP GEDE  CV+ +  GP            LQV  S   +W   C D++ E   
Sbjct: 133 CDGVSHCPGGEDENRCVRLY--GP---------NFILQVYSSQRKSWHPVCQDDWNENYG 181

Query: 137 ETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSG------------PCL 184
             ACR MGY  K  F + +        +V+ + ++  +++  S+G             C 
Sbjct: 182 RAACRDMGY--KNNFYSSQ-------GIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACS 232

Query: 185 SGSLVSLHCLACGKSLKTPR---VVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVL 241
           S ++VSL C+ACG +L + R   +VGGE A   +WPWQVS+     HVCGGSI+ P W++
Sbjct: 233 SKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIV 292

Query: 242 TAAHCFRKH-TDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMY---PKDNDIALMKLQ 297
           TAAHC  K   + ++W   AG  +       A  ++  +  +P Y    K+NDIALMKLQ
Sbjct: 293 TAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQ 352

Query: 298 FPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCN 357
            PLTF+  V+P+CLP     L P    WI GWG T++  GK S++L  A V +I++ RCN
Sbjct: 353 KPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK-GKTSEVLNAAKVLLIETQRCN 411

Query: 358 ADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQ-WHVVGIVSWGYGCGGPSTP 416
           +   Y   +T  M+CAG  +G VD+CQGDSGGPL+   +  W ++G  SWG GC     P
Sbjct: 412 SRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRP 471

Query: 417 GVYTKVSAYLNWIYNVWKAE 436
           GVY  V  + +WIY   +A+
Sbjct: 472 GVYGNVMVFTDWIYRQMRAD 491


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  243 bits (621), Expect = 2e-64
 Identities = 149/431 (34%), Positives = 219/431 (50%), Gaps = 39/431 (9%)

Query: 24  IPMETFRKVGIPIIIALLSLASIIIVVVLIKVILD-KYYFLCGQPLHFIPRKQLCDGELD 82
           +P++ F  + I II  +L+LA      + + +  D    + C      I     CDG  D
Sbjct: 44  LPLKFFPIIVIGIIALILALA------IGLGIHFDCSGKYRCRSSFKCIELIARCDGVSD 97

Query: 83  CPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQ 142
           C  GEDE  CV           R+    + LQV  +A+  W + C D++    A  AC Q
Sbjct: 98  CKDGEDEYRCV-----------RVGGQNAVLQVFTAAS--WKTMCSDDWKGHYANVACAQ 144

Query: 143 MGYSS------------KPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVS 190
           +G+ S            +  FR   +  D  L   ++T     + +R     C SG +V+
Sbjct: 145 LGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREG---CASGHVVT 201

Query: 191 LHCLACG-KSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRK 249
           L C ACG +   + R+VGG  + +  WPWQ S+Q+   H+CGGS++ P W++TAAHC   
Sbjct: 202 LQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYD 261

Query: 250 HTDVFNWKVRAGSDKL--GSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVR 307
                +W ++ G   L     PS  V KI+           NDIALMKL  PLTF+  ++
Sbjct: 262 LYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQ 321

Query: 308 PICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVT 367
           P+CLP  +E        W  GWG T+   G  S +L  A+V +I +  CN  D Y G ++
Sbjct: 322 PVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIIS 381

Query: 368 EKMMCAGIPEGGVDTCQGDSGGPLMYQSDQ-WHVVGIVSWGYGCGGPSTPGVYTKVSAYL 426
             M+CAG   GGVD+CQGDSGGPL+ Q  + W +VG  S+G GC   + PGVYT+V+++L
Sbjct: 382 PSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFL 441

Query: 427 NWIYNVWKAEL 437
           +WI+   + +L
Sbjct: 442 DWIHEQMERDL 452


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  220 bits (560), Expect = 2e-57
 Identities = 123/365 (33%), Positives = 183/365 (50%), Gaps = 19/365 (5%)

Query: 81  LDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETAC 140
           L C     EE  + + P+   V+ R++ +   L+        W   C + ++ AL    C
Sbjct: 91  LSCSEASAEEALLPALPK--TVSFRINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQIC 148

Query: 141 RQMGYSSKPTFRAVEIGPDQDLDVVEITENSQEL--------RMRNSSGPCLSGSLVSLH 192
             +G+      + V +   +     E  + S  L        + RN+   C SG +VSL 
Sbjct: 149 WSLGHLRLTHHKGVNLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNN---CTSGQVVSLR 205

Query: 193 CLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKH-- 250
           C  CG      R+VGG+  +   WPWQ S+    +H CGGS+L P WV+TAAHC      
Sbjct: 206 CSECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRL 265

Query: 251 TDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDN---DIALMKLQFPLTFSGTVR 307
             + +W+V AG     +      A +  I  +P+Y   N   D+AL++LQ  L FS TV 
Sbjct: 266 ARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVG 325

Query: 308 PICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVT 367
            +CLP  ++     +  W+ GWG T  +    SD+L    V +  +  CN+   Y G +T
Sbjct: 326 AVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALT 385

Query: 368 EKMMCAGIPEGGVDTCQGDSGGPLMY-QSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYL 426
            +M+CAG  +G  D CQGDSGGPL+    D W +VG+VSWG GC  P+ PGVY KV+ +L
Sbjct: 386 PRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFL 445

Query: 427 NWIYN 431
           +WI++
Sbjct: 446 DWIHD 450


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  219 bits (558), Expect = 4e-57
 Identities = 126/357 (35%), Positives = 180/357 (50%), Gaps = 23/357 (6%)

Query: 100 PAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEI--- 156
           P   V++S   + L V D   G W   C       +A  +C +MG+    T   +++   
Sbjct: 50  PLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTA 109

Query: 157 GPDQDLDVVEITE----NSQELRMRNSSGPCLSGSLVSLHCLACGK-SLKTPRVVGGEEA 211
           G +       + E    ++Q L    S   C  G  ++  C  CG+  L   R+VGG + 
Sbjct: 110 GANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDT 169

Query: 212 SVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFN-WKVRAGSDKLGSFPS 270
           S+  WPWQVS++YD  H+CGGS+L   WVLTAAHCF +   V + W+V AG+    S   
Sbjct: 170 SLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHG 229

Query: 271 LAVAKIIIIEFNPMYP--------KDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPAT 322
           L +    ++      P          NDIAL+ L  PL  +  ++P+CLP   + L    
Sbjct: 230 LQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGK 289

Query: 323 PLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDT 382
              + GWG T Q  G+ + +L +A V +I +  CN  D Y  ++  KM CAG PEGG+D 
Sbjct: 290 ICTVTGWGNT-QYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDA 348

Query: 383 CQGDSGGPLMYQ-----SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWK 434
           CQGDSGGP + +     + +W + GIVSWG GC     PGVYTKVS +  WI+   K
Sbjct: 349 CQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  219 bits (558), Expect = 4e-57
 Identities = 126/357 (35%), Positives = 180/357 (50%), Gaps = 23/357 (6%)

Query: 100 PAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEI--- 156
           P   V++S   + L V D   G W   C       +A  +C +MG+    T   +++   
Sbjct: 50  PLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTA 109

Query: 157 GPDQDLDVVEITE----NSQELRMRNSSGPCLSGSLVSLHCLACGK-SLKTPRVVGGEEA 211
           G +       + E    ++Q L    S   C  G  ++  C  CG+  L   R+VGG + 
Sbjct: 110 GANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDT 169

Query: 212 SVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFN-WKVRAGSDKLGSFPS 270
           S+  WPWQVS++YD  H+CGGS+L   WVLTAAHCF +   V + W+V AG+    S   
Sbjct: 170 SLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHG 229

Query: 271 LAVAKIIIIEFNPMYP--------KDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPAT 322
           L +    ++      P          NDIAL+ L  PL  +  ++P+CLP   + L    
Sbjct: 230 LQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGK 289

Query: 323 PLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDT 382
              + GWG T Q  G+ + +L +A V +I +  CN  D Y  ++  KM CAG PEGG+D 
Sbjct: 290 ICTVTGWGNT-QYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDA 348

Query: 383 CQGDSGGPLMYQ-----SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWK 434
           CQGDSGGP + +     + +W + GIVSWG GC     PGVYTKVS +  WI+   K
Sbjct: 349 CQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405


>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score =  215 bits (547), Expect = 7e-56
 Identities = 133/376 (35%), Positives = 198/376 (52%), Gaps = 34/376 (9%)

Query: 71   IPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDN 130
            +P   LCDG L C  G DE  CV+ F  G      L + R  +Q +      W +AC +N
Sbjct: 656  VPLVNLCDGHLHCEDGSDEADCVRFF-NGTTNNNGLVRFR--IQSI------WHTACAEN 706

Query: 131  FTEALAETACRQMGY----SSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSG 186
            +T  ++   C+ +G     SSKP F + + GP      V++        +   S  CL  
Sbjct: 707  WTTQISNDVCQLLGLGSGNSSKPIF-STDGGP-----FVKLNTAPDGHLILTPSQQCLQD 760

Query: 187  SLVSLHC--LACGKSLK----TPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWV 240
            SL+ L C   +CGK L     TP++VGG  A   +WPW V + Y  + +CG S++   W+
Sbjct: 761  SLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWL 820

Query: 241  LTAAHC-FRKHTDVFNWKVRAGSDKLGSFPSLAVAKIII--IEFNPMY---PKDNDIALM 294
            ++AAHC + ++ +   W    G     +  S      +I  I  NP Y    KDNDIA+M
Sbjct: 821  VSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMM 880

Query: 295  KLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDST 354
             L+F + ++  ++PICLP  ++   P     I GWG T    G  ++IL +A V ++ + 
Sbjct: 881  HLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWG-TVVYQGTTANILQEADVPLLSNE 939

Query: 355  RCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQ-SDQWHVVGIVSWGYGCGGP 413
            RC      +  +TE M+CAG  EGG+D+CQGDSGGPLM Q +++W + G+ S+GY C  P
Sbjct: 940  RCQ-QQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALP 998

Query: 414  STPGVYTKVSAYLNWI 429
            + PGVY +VS +  WI
Sbjct: 999  NRPGVYARVSRFTEWI 1014



 Score = 29.6 bits (65), Expect = 5.6
 Identities = 12/28 (42%), Positives = 16/28 (57%)

Query: 64  CGQPLHFIPRKQLCDGELDCPLGEDEEH 91
           C   L  I     CDGE++CP G DE++
Sbjct: 191 CTDALTCIKADLFCDGEVNCPDGSDEDN 218


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  209 bits (532), Expect = 4e-54
 Identities = 100/235 (42%), Positives = 148/235 (62%), Gaps = 7/235 (2%)

Query: 199 SLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKV 258
           +L   R++GG EA   SWPWQVS++ +  H CGGS+++  W+LTAAHCFR +++  +W  
Sbjct: 181 TLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIA 240

Query: 259 RAGSDKLGSFPSL--AVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDE 316
            +G     +FP L   V  I+I         +NDIAL++L+  +TF+  +  +CLP   +
Sbjct: 241 TSGIST--TFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQ 298

Query: 317 ELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIP 376
            + P +  ++ GWG  +  G  + + L Q  V++I +  CNA  +Y G +   M+CAG+P
Sbjct: 299 NIPPGSTAYVTGWGAQEYAGHTVPE-LRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVP 357

Query: 377 EGGVDTCQGDSGGPLMYQSDQ--WHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429
           +GGVD CQGDSGGPL+ +  +  W +VGIVSWG  CG P  PGVYT+V+AYL+WI
Sbjct: 358 QGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWI 412


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  194 bits (494), Expect = 1e-49
 Identities = 129/383 (33%), Positives = 190/383 (49%), Gaps = 47/383 (12%)

Query: 62  FLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATG 121
           FLC      +P    CDG  DCP G DE +CV                R+T Q  + +T 
Sbjct: 462 FLCSVNGLCVPA---CDGVKDCPNGLDERNCVC---------------RATFQCKEDSTC 503

Query: 122 NWFSACFDNFTEALA---ETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRN 178
                  D   + L    E  C++       TF+       +D   V+      + R   
Sbjct: 504 ISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQC------EDRSCVKKPNPQCDGRP-- 555

Query: 179 SSGPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPH 238
               C  GS    HC  CG    + R+VGG  +S   WPWQ S+Q   +H+CGG+++   
Sbjct: 556 ---DCRDGSDEE-HC-DCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADR 610

Query: 239 WVLTAAHCFRKHT-------DVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDI 291
           WV+TAAHCF++ +        VF  KV   S   G   S  V+++++  ++     D D+
Sbjct: 611 WVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEV-SFKVSRLLLHPYHEEDSHDYDV 669

Query: 292 ALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVI 351
           AL++L  P+  S  VRP+CLP       P    WI GWG  ++ GG +S+ L +  VQ+I
Sbjct: 670 ALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALRE-GGPISNALQKVDVQLI 728

Query: 352 DSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQ--SDQWHVVGIVSWGYG 409
               C+  + Y+ +VT +M+CAG  +G  D CQGDSGGPL+ +  S +W + G+VSWG G
Sbjct: 729 PQDLCS--EVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLG 786

Query: 410 CGGPSTPGVYTKVSAYLNWIYNV 432
           CG P+  GVYT+++  ++WI  V
Sbjct: 787 CGRPNYFGVYTRITGVISWIQQV 809


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  188 bits (478), Expect = 7e-48
 Identities = 98/235 (41%), Positives = 145/235 (61%), Gaps = 12/235 (5%)

Query: 204 RVVGGEEASVDSWPWQVSIQYD---KQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRA 260
           R+VGG  +S   WPWQVS+Q     ++H+CGGS++   WVLTAAHCF        W++ +
Sbjct: 390 RIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYS 449

Query: 261 G----SDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDE 316
           G    SD     P   + +III +   +   ++DIAL+KLQ PL ++   +PICLP   +
Sbjct: 450 GILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGD 509

Query: 317 ELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQG-EVTEKMMCAGI 375
             T  T  W+ GWGF+K+  G++ +IL + ++ ++ +  C     YQ  ++T++M+CAG 
Sbjct: 510 TSTIYTNCWVTGWGFSKEK-GEIQNILQKVNIPLVTNEEC--QKRYQDYKITQRMVCAGY 566

Query: 376 PEGGVDTCQGDSGGPLMYQ-SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429
            EGG D C+GDSGGPL+ + +  W +VGI SWG GC     PGVYTKV+ Y++WI
Sbjct: 567 KEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWI 621


>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
          Length = 438

 Score =  187 bits (475), Expect = 2e-47
 Identities = 107/286 (37%), Positives = 155/286 (54%), Gaps = 20/286 (6%)

Query: 147 SKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVV 206
           +KP+FR   + P     +  +  +   +RM +S+ P  + S              T R+V
Sbjct: 164 NKPSFR---LTPIDSKKMRNLLNSRCGIRMTSSNMPLPASS-------------STQRIV 207

Query: 207 GGEEASVDS-WPWQVSIQY-DKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDK 264
            G E +++  WPWQ S+Q     H CG S++   W+LTAAHCF K+ D   W    G+  
Sbjct: 208 QGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQWIATFGATI 267

Query: 265 LGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPL 324
                   V KII+ E       +NDIAL++L   + FS  V+ +CLP    +L P T +
Sbjct: 268 TPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSV 327

Query: 325 WIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQ 384
           ++ G+G    +G  + + L QA V+ I +  CN  D Y G +T  M+CAG  EG +D C+
Sbjct: 328 FVTGFGSIVDDG-PIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFMEGKIDACK 386

Query: 385 GDSGGPLMYQS-DQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429
           GDSGGPL+Y + D W++VGIVSWG  C  P  PGVYT+V+ Y +WI
Sbjct: 387 GDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWI 432


>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
          Length = 416

 Score =  187 bits (474), Expect = 2e-47
 Identities = 99/270 (36%), Positives = 152/270 (56%), Gaps = 14/270 (5%)

Query: 162 LDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVS 221
           + ++EI++ + E+   N  G  ++ S+++ +           ++V G+ +   +WPWQ S
Sbjct: 153 IKLMEISKAASEMLTNNCCGRQVANSIITGN-----------KIVNGKSSLEGAWPWQAS 201

Query: 222 IQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEF 281
           +Q+  +H CG S++   W+L+AAHCF K  +  +W V  G      + +  V  II  E 
Sbjct: 202 MQWKGRHYCGASLISSRWLLSAAHCFAKKNNSKDWTVNFGIVVNKPYMTRKVQNIIFHEN 261

Query: 282 NPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSD 341
                  +DIAL++L   ++F+  +R ICLP    +L+    + + GWG    N G    
Sbjct: 262 YSSPGLHDDIALVQLAEEVSFTEYIRKICLPEAKMKLSENDNVVVTGWGTLYMN-GSFPV 320

Query: 342 ILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQ--WH 399
           IL +  +++ID+  CNA  AY G VT+ M+CAG   G  D CQ DSGGPL Y   +  WH
Sbjct: 321 ILQEDFLKIIDNKICNASYAYSGFVTDTMLCAGFMSGEADACQNDSGGPLAYPDSRNIWH 380

Query: 400 VVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429
           +VGIVSWG GCG  + PGVYT+V++Y NWI
Sbjct: 381 LVGIVSWGDGCGKKNKPGVYTRVTSYRNWI 410


>gi|148613878 acrosin precursor [Homo sapiens]
          Length = 421

 Score =  185 bits (469), Expect = 8e-47
 Identities = 98/244 (40%), Positives = 135/244 (55%), Gaps = 18/244 (7%)

Query: 204 RVVGGEEASVDSWPWQVSIQY-----DKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKV 258
           R+VGG+ A   +WPW VS+Q       + H CGGS+L+  WVLTAAHCF    +V +W++
Sbjct: 42  RIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRL 101

Query: 259 RAGSDKL---------GSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPI 309
             G+ ++                V KIII E      + NDIAL+++  P++    + P 
Sbjct: 102 VFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPG 161

Query: 310 CLPFFDEELTPATP-LWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTE 368
           CLP F   L   +   W+ GWG+ ++   + S IL++A V +ID   CN+   Y G V  
Sbjct: 162 CLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQP 221

Query: 369 KMMCAGIPEGGVDTCQGDSGGPLMYQSDQ---WHVVGIVSWGYGCGGPSTPGVYTKVSAY 425
             +CAG P G +DTCQGDSGGPLM +  +   + VVGI SWG GC     PG+YT    Y
Sbjct: 222 TNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPY 281

Query: 426 LNWI 429
           LNWI
Sbjct: 282 LNWI 285


>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
          Length = 423

 Score =  184 bits (466), Expect = 2e-46
 Identities = 94/243 (38%), Positives = 135/243 (55%), Gaps = 6/243 (2%)

Query: 192 HCLACGKSL---KTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFR 248
           HC    +S    ++ R+VGG E     WPWQ S+Q+D  H CG ++++  W+++AAHCF 
Sbjct: 176 HCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFT 235

Query: 249 KHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRP 308
            + +   W    G     S     + +II+ E       D DI+L +L  P+ ++  V  
Sbjct: 236 TYKNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHR 295

Query: 309 ICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTE 368
           +CLP    E  P   +++ G+G  K N G   + L QA V +ID+T CN   AY   +T 
Sbjct: 296 VCLPDASYEFQPGDVMFVTGFGALK-NDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITP 354

Query: 369 KMMCAGIPEGGVDTCQGDSGGPLMYQS--DQWHVVGIVSWGYGCGGPSTPGVYTKVSAYL 426
           +M+CAG  EG  D CQGDSGGPL+     D W++ GIVSWG  C  P+ PGVYT+V+A  
Sbjct: 355 RMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALR 414

Query: 427 NWI 429
           +WI
Sbjct: 415 DWI 417


>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
          Length = 423

 Score =  184 bits (466), Expect = 2e-46
 Identities = 94/243 (38%), Positives = 135/243 (55%), Gaps = 6/243 (2%)

Query: 192 HCLACGKSL---KTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFR 248
           HC    +S    ++ R+VGG E     WPWQ S+Q+D  H CG ++++  W+++AAHCF 
Sbjct: 176 HCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFT 235

Query: 249 KHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRP 308
            + +   W    G     S     + +II+ E       D DI+L +L  P+ ++  V  
Sbjct: 236 TYKNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHR 295

Query: 309 ICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTE 368
           +CLP    E  P   +++ G+G  K N G   + L QA V +ID+T CN   AY   +T 
Sbjct: 296 VCLPDASYEFQPGDVMFVTGFGALK-NDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITP 354

Query: 369 KMMCAGIPEGGVDTCQGDSGGPLMYQS--DQWHVVGIVSWGYGCGGPSTPGVYTKVSAYL 426
           +M+CAG  EG  D CQGDSGGPL+     D W++ GIVSWG  C  P+ PGVYT+V+A  
Sbjct: 355 RMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALR 414

Query: 427 NWI 429
           +WI
Sbjct: 415 DWI 417


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  183 bits (464), Expect = 3e-46
 Identities = 103/248 (41%), Positives = 136/248 (54%), Gaps = 13/248 (5%)

Query: 195 ACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVF 254
           ACG+   + R+VGG +     WPWQ SIQ+   HVCGGS++ P WVLTAAHCF +     
Sbjct: 27  ACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPRRALPA 86

Query: 255 NWKVRAGSDKLGS-FPSLAVAKIIIIEFNPMYPKD---NDIALMKLQFPLTFSGTVRPIC 310
            ++VR G+ +LGS  P      +  +   P Y +D    D+AL++L+ P+  S  V+P+C
Sbjct: 87  EYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSARVQPVC 146

Query: 311 LPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQ-ASVQVIDSTRCN-----ADDAYQG 364
           LP       P TP  + GWG  +          LQ   V ++DS  C+       D  Q 
Sbjct: 147 LPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGADVPQA 206

Query: 365 E--VTEKMMCAGIPEGGVDTCQGDSGGPL-MYQSDQWHVVGIVSWGYGCGGPSTPGVYTK 421
           E  V    +CAG P+G  D CQGDSGGPL   QS  W +VG+VSWG GC  P+ PGVYT 
Sbjct: 207 ERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRPGVYTS 266

Query: 422 VSAYLNWI 429
           V+ Y  WI
Sbjct: 267 VATYSPWI 274


>gi|205360905 testis-specific serine protease 1 [Homo sapiens]
          Length = 318

 Score =  182 bits (463), Expect = 4e-46
 Identities = 95/251 (37%), Positives = 138/251 (54%), Gaps = 13/251 (5%)

Query: 195 ACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVF 254
           ACG       V GG E++   WPWQ S++  ++H CGGS+L   WVL+AAHCF+KH    
Sbjct: 45  ACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPS 104

Query: 255 NWKVRAGS-------DKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVR 307
            W V+ G          L ++ S    + II+  + +    NDIAL++L   +T++  ++
Sbjct: 105 EWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQ 164

Query: 308 PICLPFFDEELTPATPLWIIGWGFTKQNGGKMSD--ILLQASVQVIDSTRCN---ADDAY 362
           PIC+             W+ GWG    +G  +     L +A V ++++TRCN      + 
Sbjct: 165 PICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSS 224

Query: 363 QGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD-QWHVVGIVSWGYGCGGPSTPGVYTK 421
           +  + + M CAG  +G VDTC+GDSGGPL+   D  W+ VGIVSWG  CG P+ PGVYT 
Sbjct: 225 RSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTN 284

Query: 422 VSAYLNWIYNV 432
           +S Y +WI  V
Sbjct: 285 ISVYFHWIRRV 295


>gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]
          Length = 321

 Score =  182 bits (463), Expect = 4e-46
 Identities = 95/234 (40%), Positives = 132/234 (56%), Gaps = 13/234 (5%)

Query: 204 RVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSD 263
           R+VGG  A   +WPWQ S++  + HVCGGS+L P WVLTAAHCF    +  +++V  G  
Sbjct: 37  RIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGEL 96

Query: 264 KLGSFPSLAVAKIIIIEFNP--MYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPA 321
           ++   P  +  + II+  +P        DIAL++L  P+T S  + P+CLP   ++  P 
Sbjct: 97  EITLSPHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPG 156

Query: 322 TPLWIIGWGFTKQNGGKMSDI-LLQASVQVIDSTRCNADDAYQGE----VTEKMMCAGIP 376
              W+ GWG+T++         L +  V V+D+  C  D  Y G     +   M+CA   
Sbjct: 157 IRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRD--YPGPGGSILQPDMLCA--- 211

Query: 377 EGGVDTCQGDSGGPLMYQ-SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429
            G  D CQ DSGGPL+ Q +  W   GIVSWG GCG P+ PGVYT+V AY+NWI
Sbjct: 212 RGPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWI 265


>gi|5803197 testisin isoform 1 [Homo sapiens]
          Length = 314

 Score =  182 bits (461), Expect = 7e-46
 Identities = 98/251 (39%), Positives = 146/251 (58%), Gaps = 19/251 (7%)

Query: 196 CGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFN 255
           CG+ + T R+VGGE+A +  WPWQ S++    HVCG S+L   W LTAAHCF  ++D+ +
Sbjct: 33  CGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETYSDLSD 92

Query: 256 ---WKVRAGSDKLGSFPSLAVAK-------IIIIEFNPMYPKDN--DIALMKLQFPLTFS 303
              W V+ G  +L S PS    +       +  I  +P Y  ++  DIAL+KL  P+T++
Sbjct: 93  PSGWMVQFG--QLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYT 150

Query: 304 GTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQ-ASVQVIDSTRCN---AD 359
             ++PICL     E    T  W+ GWG+ K++    S   LQ   V +I+++ CN     
Sbjct: 151 KHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLK 210

Query: 360 DAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPL-MYQSDQWHVVGIVSWGYGCGGPSTPGV 418
            +++ ++   M+CAG  +GG D C GDSGGPL   ++  W+ +G+VSWG GCG P+ PGV
Sbjct: 211 YSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGV 270

Query: 419 YTKVSAYLNWI 429
           YT +S +  WI
Sbjct: 271 YTNISHHFEWI 281


>gi|21614531 testisin isoform 2 [Homo sapiens]
          Length = 312

 Score =  180 bits (456), Expect = 3e-45
 Identities = 98/249 (39%), Positives = 143/249 (57%), Gaps = 17/249 (6%)

Query: 196 CGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKH-TDVF 254
           CG+ + T R+VGGE+A +  WPWQ S++    HVCG S+L   W LTAAHCF    +D  
Sbjct: 33  CGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDPS 92

Query: 255 NWKVRAGSDKLGSFPSLAVAK-------IIIIEFNPMYPKDN--DIALMKLQFPLTFSGT 305
            W V+ G  +L S PS    +       +  I  +P Y  ++  DIAL+KL  P+T++  
Sbjct: 93  GWMVQFG--QLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKH 150

Query: 306 VRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQ-ASVQVIDSTRCN---ADDA 361
           ++PICL     E    T  W+ GWG+ K++    S   LQ   V +I+++ CN      +
Sbjct: 151 IQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYS 210

Query: 362 YQGEVTEKMMCAGIPEGGVDTCQGDSGGPL-MYQSDQWHVVGIVSWGYGCGGPSTPGVYT 420
           ++ ++   M+CAG  +GG D C GDSGGPL   ++  W+ +G+VSWG GCG P+ PGVYT
Sbjct: 211 FRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYT 270

Query: 421 KVSAYLNWI 429
            +S +  WI
Sbjct: 271 NISHHFEWI 279


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  179 bits (454), Expect = 4e-45
 Identities = 96/260 (36%), Positives = 143/260 (55%), Gaps = 13/260 (5%)

Query: 186 GSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAH 245
           GS  +    ACG+     R+VGG++     WPWQVSIQ +  H CGGS++   WVLTAAH
Sbjct: 16  GSQRAKAATACGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTAAH 75

Query: 246 CFRKHTDVFNWKVRAGSDKL-GSFPSLAVAKIIIIEFNPMY---PKDNDIALMKLQFPLT 301
           CFR  ++   ++V  G+ +L    P    A++  +E NP+Y       D+AL++L+ P+ 
Sbjct: 76  CFRNTSETSLYQVLLGARQLVQPGPHAMYARVRQVESNPLYQGTASSADVALVELEAPVP 135

Query: 302 FSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQ-ASVQVIDSTRCN--- 357
           F+  + P+CLP            W+ GWG   +        +LQ  +V +ID+ +CN   
Sbjct: 136 FTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLY 195

Query: 358 ---ADDAYQGE-VTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQ-WHVVGIVSWGYGCGG 412
               +  YQ + +   M+CAG  EG  D C+GDSGGPL+    Q W   G++SWG GC  
Sbjct: 196 SKDTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQAGVISWGEGCAR 255

Query: 413 PSTPGVYTKVSAYLNWIYNV 432
            + PGVY +V+A+ NWI+ +
Sbjct: 256 QNRPGVYIRVTAHHNWIHRI 275


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  178 bits (452), Expect = 8e-45
 Identities = 89/232 (38%), Positives = 141/232 (60%), Gaps = 8/232 (3%)

Query: 204 RVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSD 263
           R+VGG EAS   +PWQ S++ +K+H CG +I++  W+++AAHCF +  D   W    G+ 
Sbjct: 202 RIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDPTKWVAYVGAT 261

Query: 264 KL-GSFPSLAVAKIIIIEFNPMYPKDN---DIALMKLQFPLTFSGTVRPICLPFFDEELT 319
            L GS  S   A+++ I  +P+Y  D    D+A+++L  PL F   ++P+CLP       
Sbjct: 262 YLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATHIFP 321

Query: 320 PATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGG 379
           P+    I GWG+ K++     ++L +A+V+++D   C +   Y   +T++M+CAG  +G 
Sbjct: 322 PSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS--LYGHSLTDRMVCAGYLDGK 379

Query: 380 VDTCQGDSGGPLMYQ--SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429
           VD+CQGDSGGPL+ +  S ++ + GIVSWG GC     PGVY +V+   +WI
Sbjct: 380 VDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWI 431



 Score =  173 bits (438), Expect = 3e-43
 Identities = 93/231 (40%), Positives = 131/231 (56%), Gaps = 8/231 (3%)

Query: 204  RVVGGEEASVDSWPWQVSIQYDK-QHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGS 262
            R+VGG  A    WPWQVS+   + +H CG  ++   W+L+AAHCF  + D   W    G+
Sbjct: 826  RIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGT 885

Query: 263  DKLGSFPSLA--VAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTP 320
              L         VA+I    F  +Y  D D+AL++L  P+  S  VRPICLP        
Sbjct: 886  PFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRPPD 945

Query: 321  ATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGV 380
             T   I GWG  ++ GG M+  L +A+V+++    C     Y  +++ +M+CAG P+GGV
Sbjct: 946  GTRCVITGWGSVRE-GGSMARQLQKAAVRLLSEQTCRR--FYPVQISSRMLCAGFPQGGV 1002

Query: 381  DTCQGDSGGPLMYQ--SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429
            D+C GD+GGPL  +  S +W + G+ SWGYGCG P  PGVYT+V+A   WI
Sbjct: 1003 DSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWI 1053



 Score =  167 bits (422), Expect = 2e-41
 Identities = 88/245 (35%), Positives = 139/245 (56%), Gaps = 15/245 (6%)

Query: 201 KTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRA 260
           K  RVVGG  A+    PWQVS++   +H CG +++   W+L+AAHCF  HT V   +   
Sbjct: 500 KPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCF-NHTKVEQVRAHL 558

Query: 261 GSDKL----GSFPSLAVAKIIIIEFNPMYPK---DNDIALMKLQFPLTFSGTVRPICLPF 313
           G+  L    GS   + + ++++   +P+Y     D D+A+++L  PL F+  ++P+CLP 
Sbjct: 559 GTASLLGLGGSPVKIGLRRVVL---HPLYNPGILDFDLAVLELASPLAFNKYIQPVCLPL 615

Query: 314 FDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCA 373
             ++        I GWG T++      ++L +ASV +ID   C+    Y   +T++M+CA
Sbjct: 616 AIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSV--LYNFSLTDRMICA 673

Query: 374 GIPEGGVDTCQGDSGGPLMYQS--DQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYN 431
           G  EG VD+CQGDSGGPL  +     +++ GIVSWG GC     PGVYT+++    WI  
Sbjct: 674 GFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILE 733

Query: 432 VWKAE 436
           +  ++
Sbjct: 734 IMSSQ 738


>gi|11545839 protease, serine, 22 [Homo sapiens]
          Length = 317

 Score =  178 bits (452), Expect = 8e-45
 Identities = 106/251 (42%), Positives = 146/251 (58%), Gaps = 15/251 (5%)

Query: 195 ACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTD-V 253
           ACGK  +  RVVGGE+++   WPW VSIQ +  H C GS+L   WV+TAAHCF+ + +  
Sbjct: 40  ACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKP 99

Query: 254 FNWKVRAGSDKLGSFPSLAVAKIII--IEFNPMYPKDN----DIALMKLQFPLTFSGTVR 307
           + + V  G+ +LG+ P     K+ +  +E +P+Y        DIAL++L+  + FS  V 
Sbjct: 100 YLFSVLLGAWQLGN-PGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVL 158

Query: 308 PICLPFFDEELTPATPLWIIGWGFTKQNGGKM--SDILLQASVQVIDSTRCNA---DDAY 362
           PICLP     L P T  WI GWG + Q+G  +     L +  V +IDS  C+      A 
Sbjct: 159 PICLPDASIHLPPNTHCWISGWG-SIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAG 217

Query: 363 QGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD-QWHVVGIVSWGYGCGGPSTPGVYTK 421
           QG +TE M+CAG  EG  D C GDSGGPLM Q D  W + GI+SWG GC   + PGVY  
Sbjct: 218 QGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYIS 277

Query: 422 VSAYLNWIYNV 432
           +SA+ +W+  +
Sbjct: 278 LSAHRSWVEKI 288


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score =  175 bits (444), Expect = 6e-44
 Identities = 125/384 (32%), Positives = 190/384 (49%), Gaps = 46/384 (11%)

Query: 71   IPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDN 130
            + R   CDGE DC    DE  CV        +++ ++   S L V  +AT +    C D 
Sbjct: 668  VSRDLWCDGEADCSDSSDEWDCV-------TLSINVNSS-SFLMVHRAATEH--HVCADG 717

Query: 131  FTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQ----------ELRMRNSS 180
            + E L++ AC+QMG       + ++   +Q+ +   +T +S           EL +   S
Sbjct: 718  WQEILSQLACKQMGLGEPSVTKLIQ---EQEKEPRWLTLHSNWESLNGTTLHELLVNGQS 774

Query: 181  GPCLSGSLVSLHCLA--CGK---SLKTPRVVGGEEASVDSWPWQVSIQYDKQ-HVCGGSI 234
              C S S +SL C    CG+   +    R++GG  +    WPWQ S+Q +   H+CG  +
Sbjct: 775  --CESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVL 832

Query: 235  LDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGS---FPSLAVAKIIIIEFNPMYPK---D 288
            +   WVLT AHCF    +   WKV  G + L     F      K II+  +P Y +   D
Sbjct: 833  IAKKWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIIL--HPRYSRAVVD 890

Query: 289  NDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASV 348
             DI++++L   ++ +G VRP+CLP  ++ L P T  +I GWG     G KM   L +  V
Sbjct: 891  YDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWGHM---GNKMPFKLQEGEV 947

Query: 349  QVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQ--SDQWHVVGIVSW 406
            ++I    C +    +  +T +M+CAG   G VD+C GDSGGPL+ +    +W + G+ SW
Sbjct: 948  RIISLEHCQSYFDMK-TITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSW 1006

Query: 407  GYGCGGPST-PGVYTKVSAYLNWI 429
            G  C      PGVY+ VS ++ WI
Sbjct: 1007 GSVCFSKVLGPGVYSNVSYFVEWI 1030



 Score = 30.0 bits (66), Expect = 4.3
 Identities = 12/22 (54%), Positives = 14/22 (63%)

Query: 71  IPRKQLCDGELDCPLGEDEEHC 92
           IP    CDG+ DC  G DEE+C
Sbjct: 393 IPSTFQCDGDEDCKDGSDEENC 414


>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
           sapiens]
          Length = 418

 Score =  174 bits (440), Expect = 2e-43
 Identities = 91/240 (37%), Positives = 130/240 (54%), Gaps = 6/240 (2%)

Query: 195 ACGKS---LKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHT 251
           +CGK    L   R+  G  A   +WPWQ S+QYD  H CG +++   W++TAAHCF+K+ 
Sbjct: 174 SCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYK 233

Query: 252 DVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICL 311
           +   W V  G+          V + II E      ++ DIA++++   +TFS  +R ICL
Sbjct: 234 NPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICL 293

Query: 312 PFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMM 371
           P       P   + I G+G     GG+  + L +A V++I    C     Y  ++   M 
Sbjct: 294 PEASASFQPNLTVHITGFG-ALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMF 352

Query: 372 CAGIPEGGVDTCQGDSGGPLMYQ--SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429
           CAG  EG  D C+GDSGGPL+ +   D W+++GIVSWG  CG    PGVYT+V+ Y NWI
Sbjct: 353 CAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWI 412


>gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo
           sapiens]
          Length = 421

 Score =  174 bits (440), Expect = 2e-43
 Identities = 91/240 (37%), Positives = 130/240 (54%), Gaps = 6/240 (2%)

Query: 195 ACGKS---LKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHT 251
           +CGK    L   R+  G  A   +WPWQ S+QYD  H CG +++   W++TAAHCF+K+ 
Sbjct: 177 SCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYK 236

Query: 252 DVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICL 311
           +   W V  G+          V + II E      ++ DIA++++   +TFS  +R ICL
Sbjct: 237 NPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICL 296

Query: 312 PFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMM 371
           P       P   + I G+G     GG+  + L +A V++I    C     Y  ++   M 
Sbjct: 297 PEASASFQPNLTVHITGFG-ALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMF 355

Query: 372 CAGIPEGGVDTCQGDSGGPLMYQ--SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429
           CAG  EG  D C+GDSGGPL+ +   D W+++GIVSWG  CG    PGVYT+V+ Y NWI
Sbjct: 356 CAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWI 415


>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
          Length = 717

 Score =  172 bits (437), Expect = 4e-43
 Identities = 120/377 (31%), Positives = 176/377 (46%), Gaps = 37/377 (9%)

Query: 62  FLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATG 121
           F C   L  +P+ Q CDG  DC    DE  CV      P  A   S  R          G
Sbjct: 363 FRCSSGL-CVPQAQRCDGVNDCFDESDELFCVS-----PQPACNTSSFRQH--------G 408

Query: 122 NWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSG 181
                 F +      E  C Q    +  TF+          D+    +N++     + + 
Sbjct: 409 PLICDGFRDCENGRDEQNCTQSIPCNNRTFKCGN-------DICFRKQNAK----CDGTV 457

Query: 182 PCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVL 241
            C  GS     C     S    R++GG +     WPWQVS+ +     CG S++   W+L
Sbjct: 458 DCPDGSDEE-GCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLL 516

Query: 242 TAAHCF--RKHTDVFNWKVRAGSDKLGSFPSLA-VAKIIIIEFNPMYPKDNDIALMKLQ- 297
           +AAHCF   + +D   W    G    G+   ++ V +I++ E+      D DIAL++L  
Sbjct: 517 SAAHCFHGNRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSI 576

Query: 298 -FPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRC 356
            +P T    ++PIC+P   + +      W+ GWG   +   K S +L QA V++ID T C
Sbjct: 577 AWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLC 636

Query: 357 NADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQ---SDQWHVVGIVSWGYGCGGP 413
            +     G +T +M+CAGI  G  D C+GDSGGPL  +     +W + GIVSWG+G G P
Sbjct: 637 VST---YGIITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRP 693

Query: 414 STPGVYTKVSAYLNWIY 430
           + PGVYT+VS ++ WI+
Sbjct: 694 NFPGVYTRVSNFVPWIH 710


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.442 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,292,334
Number of Sequences: 37866
Number of extensions: 850302
Number of successful extensions: 2631
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 190
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 1649
Number of HSP's gapped (non-prelim): 470
length of query: 437
length of database: 18,247,518
effective HSP length: 105
effective length of query: 332
effective length of database: 14,271,588
effective search space: 4738167216
effective search space used: 4738167216
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.