Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 154275765
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
(525 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 1129 0.0
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 1129 0.0
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 799 0.0
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 284 2e-76
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 275 6e-74
gi|145309328 papilin [Homo sapiens] 259 3e-69
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 256 4e-68
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 238 1e-62
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 236 5e-62
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 233 3e-61
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 230 2e-60
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 226 5e-59
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 218 1e-56
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 215 9e-56
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 214 1e-55
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 213 5e-55
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 213 5e-55
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 202 8e-52
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 201 1e-51
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 193 3e-49
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 177 2e-44
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 164 2e-40
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 164 2e-40
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 164 2e-40
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 159 8e-39
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 156 5e-38
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 149 6e-36
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 149 6e-36
gi|226442878 ADAMTS-like 5 [Homo sapiens] 138 1e-32
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 132 8e-31
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 1129 bits (2919), Expect = 0.0
Identities = 525/525 (100%), Positives = 525/525 (100%)
Query: 1 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC 60
MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC
Sbjct: 1 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC 60
Query: 61 LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS 120
LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS
Sbjct: 61 LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS 120
Query: 121 LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG 180
LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG
Sbjct: 121 LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG 180
Query: 181 DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS 240
DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS
Sbjct: 181 DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS 240
Query: 241 LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR 300
LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR
Sbjct: 241 LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR 300
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC
Sbjct: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
Query: 421 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKP 480
MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKP
Sbjct: 421 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKP 480
Query: 481 HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPS 525
HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPS
Sbjct: 481 HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPS 525
Score = 101 bits (251), Expect = 2e-21
Identities = 56/170 (32%), Positives = 79/170 (46%), Gaps = 26/170 (15%)
Query: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLD 357
++ W F CS +CGGG Q C + ++ + C + +P L+ CNLD
Sbjct: 608 LYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLC---VTSRRPPQLLKSCNLD 664
Query: 358 PCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSC---VEEDIQGHVTS 414
PCPA RWE W+ CS +CG G+Q+R V C + ++ V
Sbjct: 665 PCPA-----------------RWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVIL 707
Query: 415 VEEWKCMYTPKMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLC 463
+E PK Q CN F+C P W +W PC+ TCG G++ R VLC
Sbjct: 708 ADE--LCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC 755
Score = 94.4 bits (233), Expect = 2e-19
Identities = 56/175 (32%), Positives = 74/175 (42%), Gaps = 31/175 (17%)
Query: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNR-----VVADQYCHYYPENIKPKPK 350
P RW + PCS TCG G Q C L S ++AD+ C +PKP
Sbjct: 665 PCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCR------QPKPS 718
Query: 351 -LQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQ 409
+Q CN CP P W W CS +CGGG+Q R V C +
Sbjct: 719 TVQACNRFNCP-----------------PAWYPAQWQPCSRTCGGGVQKREVLCKQRMAD 761
Query: 410 GHVTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLC 463
G + E C K Q C DCP +WL +W+ C+ +CG+G + R +C
Sbjct: 762 GSFLELPETFCS-ASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAIC 815
Score = 83.2 bits (204), Expect = 5e-16
Identities = 62/180 (34%), Positives = 86/180 (47%), Gaps = 28/180 (15%)
Query: 303 ETDFFP-----CSATCGGGYQLTSAECYDLRS-NRVVADQYCHYYPENIKPKPKLQE-CN 355
E F P C+ TCG G Q+ C L S ++ VAD E PKP Q C
Sbjct: 523 EPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPID---ECEGPKPASQRACY 579
Query: 356 LDPCPA---------SDG-YKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVE 405
PC +DG + + +D L WE +T CS SCGGG+Q VSC+
Sbjct: 580 AGPCSGEIPEFNPDETDGLFGGLQDFD---ELYDWEYEGFTKCSESCGGGVQEAVVSCLN 636
Query: 406 EDIQGHVTSVEEWKCMYTPKMP-IAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLC 463
+ + EE C+ + + P + + CN+ CP +W +WSPC++TCG GL+ R V C
Sbjct: 637 KQTR---EPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFC 693
Score = 76.3 bits (186), Expect = 7e-14
Identities = 54/193 (27%), Positives = 77/193 (39%), Gaps = 29/193 (15%)
Query: 301 WRETDFFPCSATCGG-GYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
W CSA+CG G Q C L ++ V +C ++P + CN C
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRC--LLNSTEVNPAHC---AGKVRPAVQPIACNRRDC 1545
Query: 360 PASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
P+ RW T W+AC+ SCGGG+Q+R V+C + G T V
Sbjct: 1546 PS-----------------RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDM 1588
Query: 420 CMYTPKMPI-AQPCNIFDCPKWLAQEWSPCTVTC---GQGLRYRVVLCIDHRG--MHTGG 473
C K P+ Q CN C +W W C C +++R V C G + +
Sbjct: 1589 CTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQ 1648
Query: 474 CSPKTKPHIKEEC 486
CS +P + C
Sbjct: 1649 CSALPRPVSTQNC 1661
Score = 59.7 bits (143), Expect = 6e-09
Identities = 42/142 (29%), Positives = 55/142 (38%), Gaps = 25/142 (17%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENI--KPKPKLQE-CNLD 357
W + PCS TCGGG Q C + +AD PE KP Q+ C D
Sbjct: 732 WYPAQWQPCSRTCGGGVQKREVLC-----KQRMADGSFLELPETFCSASKPACQQACKKD 786
Query: 358 PCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEE 417
CP+ W + WT CS+SCG G Q+R+ C + G T V
Sbjct: 787 DCPSE-----------------WLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNS 829
Query: 418 WKCMYTPKMPIAQPCNIFDCPK 439
C P +PC + C +
Sbjct: 830 TLCPPLPFSSSIRPCMLATCAR 851
Score = 58.2 bits (139), Expect = 2e-08
Identities = 51/201 (25%), Positives = 74/201 (36%), Gaps = 31/201 (15%)
Query: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
RW T + C+ +CGGG Q C L+++ + + K Q CN C
Sbjct: 1548 RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC 1607
Query: 360 PASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGG---GIQSRAVSCVEEDIQGHVTSVE 416
W + W C+ C G +Q R V C D +T
Sbjct: 1608 ------------------VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRD---GITLPS 1646
Query: 417 EWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQ-GLRYRVVLCI---DHRGMHT 471
E +C P+ Q C C W W+ CT TCG G + R V C+ ++ +
Sbjct: 1647 E-QCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPE 1705
Query: 472 GGCSPKTKPHIKEECIVPTPC 492
CS +P + C + TPC
Sbjct: 1706 HLCSWGPRPANWQRCNI-TPC 1725
Score = 30.4 bits (67), Expect = 4.1
Identities = 20/61 (32%), Positives = 22/61 (36%), Gaps = 14/61 (22%)
Query: 38 AWGP--WSECSRTCGGGASYSLRRC-----------LSSKSCE-GRNIRYRTCSNVDCPP 83
AW P W CSRTCGGG C L C + + C DCP
Sbjct: 731 AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPS 790
Query: 84 E 84
E
Sbjct: 791 E 791
Score = 30.0 bits (66), Expect = 5.4
Identities = 20/81 (24%), Positives = 29/81 (35%), Gaps = 14/81 (17%)
Query: 42 WSECSRTCGGGASYSLRRC------------LSSKSCEG-RNIRYRTCSNVDCPPEAGDF 88
WS C+ TCG G + RC L CEG + R C C E +F
Sbjct: 531 WSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEF 590
Query: 89 RAQQCSA-HNDVKHHGQFYEW 108
+ ++ + Y+W
Sbjct: 591 NPDETDGLFGGLQDFDELYDW 611
Score = 29.6 bits (65), Expect = 7.1
Identities = 21/69 (30%), Positives = 30/69 (43%), Gaps = 14/69 (20%)
Query: 40 GPWSECSRTCGGG-------ASYSLRR------CLSSKSC-EGRNIRYRTCSNVDCPPEA 85
G WS CS TCG G S+ L R L+ + C + + + C+ +CPP
Sbjct: 673 GKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAW 732
Query: 86 GDFRAQQCS 94
+ Q CS
Sbjct: 733 YPAQWQPCS 741
Score = 29.3 bits (64), Expect = 9.2
Identities = 13/39 (33%), Positives = 25/39 (64%), Gaps = 1/39 (2%)
Query: 30 EDRDGLWD-AWGPWSECSRTCGGGASYSLRRCLSSKSCE 67
+D D L+D + +++CS +CGGG ++ CL+ ++ E
Sbjct: 603 QDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTRE 641
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 1129 bits (2919), Expect = 0.0
Identities = 525/525 (100%), Positives = 525/525 (100%)
Query: 1 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC 60
MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC
Sbjct: 1 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC 60
Query: 61 LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS 120
LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS
Sbjct: 61 LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS 120
Query: 121 LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG 180
LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG
Sbjct: 121 LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG 180
Query: 181 DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS 240
DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS
Sbjct: 181 DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS 240
Query: 241 LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR 300
LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR
Sbjct: 241 LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR 300
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC
Sbjct: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
Query: 421 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKP 480
MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKP
Sbjct: 421 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKP 480
Query: 481 HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPS 525
HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPS
Sbjct: 481 HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPS 525
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 799 bits (2063), Expect = 0.0
Identities = 347/504 (68%), Positives = 417/504 (82%)
Query: 22 SSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDC 81
+SR RS+ED+DG WDAWG WS+CSRTCGGGASYSLRRCL+ ++CEG+NIRY+TCSN DC
Sbjct: 64 TSRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDC 123
Query: 82 PPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDG 141
PP+A DFRAQQCSA+NDV++ G +YEWLP NDP PC+LKC A+G LVVELAPKVLDG
Sbjct: 124 PPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDG 183
Query: 142 TRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKS 201
TRC T+SLDMCISG+CQ VGCD QLGS KEDNCGVC GDGSTCRLVRGQ KS +S K
Sbjct: 184 TRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKR 243
Query: 202 DDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPD 261
++ V+A+P GSR +R+ +KGP HL++E+KTLQG+KGE+S +S G FLV+N++V+FQ+ +
Sbjct: 244 EENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSE 303
Query: 262 KEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTS 321
++ ++ GPL ADFI K R + + DS VQF FYQPI H+WR+TDFFPC+ TCGGGYQL S
Sbjct: 304 RQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNS 363
Query: 322 AECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPYDLYHPLPRWE 381
AEC D+R RVV D YCHYYPEN+KPKPKL+EC++DPCP+SDG+K+IMPYD + PLPRWE
Sbjct: 364 AECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWE 423
Query: 382 ATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWL 441
PWTACS SCGGGIQ R+ CVEE + G + VEEWKCMY PK + Q CN+FDCPKW+
Sbjct: 424 HNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWI 483
Query: 442 AQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPV 501
A EWS CTVTCG+GLRYRVVLCI+HRG H GGC+P+ K HIKEEC++P PCYKPKEK PV
Sbjct: 484 AMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPV 543
Query: 502 EAKLPWFKQAQELEEGAAVSEEPS 525
EAKLPW KQAQELEE +EEP+
Sbjct: 544 EAKLPWLKQAQELEETRIATEEPT 567
Score = 99.8 bits (247), Expect = 6e-21
Identities = 58/164 (35%), Positives = 75/164 (45%), Gaps = 26/164 (15%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
W F PC+ATC GG+Q A C +++ + V D C +P Q CN +PCP
Sbjct: 648 WEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVH---RPPAMSQACNTEPCP 704
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
PRW W CS++CG GIQ+R V C+ G + E +C
Sbjct: 705 -----------------PRWHVGSWGPCSATCGVGIQTRDVYCLH---PGETPAPPE-EC 743
Query: 421 MYTPKMPIAQPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVVLC 463
K Q CN FDCP W +EW C+ TCG G + R V C
Sbjct: 744 R-DEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTC 786
Score = 73.2 bits (178), Expect = 6e-13
Identities = 58/193 (30%), Positives = 85/193 (44%), Gaps = 29/193 (15%)
Query: 309 CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKL---QECNLDPCPASDGY 365
CS TCG G Q+ +C L + + PE PKL + C L+ C S
Sbjct: 576 CSTTCGPGVQVREVKCRVLLTFTQTETEL----PEEECEGPKLPTERPCLLEACDESPAS 631
Query: 366 KQIMPYDLYHPLPR-------WEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEW 418
+++ D+ PLP WE +T C+++C GG Q C+ Q +V +
Sbjct: 632 REL---DI--PLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQ---QTVNDS 683
Query: 419 KCMYTPKMP-IAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTG---G 473
C + P ++Q CN CP +W W PC+ TCG G++ R V C+ H G
Sbjct: 684 LCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCL-HPGETPAPPEE 742
Query: 474 CSPKTKPHIKEEC 486
C + KPH + C
Sbjct: 743 CRDE-KPHALQAC 754
Score = 68.9 bits (167), Expect = 1e-11
Identities = 46/135 (34%), Positives = 67/135 (49%), Gaps = 18/135 (13%)
Query: 378 PRWEATPWTACSSSCGG-GIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIA--QPCNI 434
P WE W+ CS++CG G + + CV + Q V E C + K P+A +PCNI
Sbjct: 1426 PFWEPGNWSHCSATCGHLGARIQRPQCVMANGQ----EVSEALCDHLQK-PLAGFEPCNI 1480
Query: 435 FDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHT------GGCSPKTKPHIKEECI 487
DCP +W WS C+V+CG+G R V C + T C+PK +P ++ C
Sbjct: 1481 RDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCF 1540
Query: 488 VPTPC--YKPKEKLP 500
PC ++P + P
Sbjct: 1541 -GHPCVQWEPGNRCP 1554
Score = 64.7 bits (156), Expect = 2e-10
Identities = 46/188 (24%), Positives = 74/188 (39%), Gaps = 25/188 (13%)
Query: 301 WRETDFFPCSATCGG-GYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
W ++ CSATCG G ++ +C + + + V++ C + KP + CN+ C
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCV-MANGQEVSEALCDHLQ---KPLAGFEPCNIRDC 1483
Query: 360 PASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
PA RW + W+ CS SCG G SR V+C G V V
Sbjct: 1484 PA-----------------RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRA 1526
Query: 420 CMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTC-GQGLRYRVVLCIDHRGMHTGGCSPKT 478
C + +PC C +W + + C C G+ +R + C +
Sbjct: 1527 CAPKDRPLGRKPCFGHPCVQW--EPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRK 1584
Query: 479 KPHIKEEC 486
+P ++ C
Sbjct: 1585 RPTLRRNC 1592
Score = 59.3 bits (142), Expect = 8e-09
Identities = 49/189 (25%), Positives = 67/189 (35%), Gaps = 44/189 (23%)
Query: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSN---RVVADQYCHYYPENIKPKPKLQECNL 356
RW + + CS +CG GY C ++N +VV+ + C PK +
Sbjct: 1486 RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRAC---------APKDRPLGR 1536
Query: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGG---IQSRAVSCVEEDIQGHVT 413
PC HP +WE P C C G +Q R +C +
Sbjct: 1537 KPC-------------FGHPCVQWE--PGNRCPGRCMGRAVRMQQRHTACQHNSSDSN-- 1579
Query: 414 SVEEWKCMYTPKMPIAQPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTG 472
C + + + C C W W PCT CG+G + R V CI HT
Sbjct: 1580 ------CDDRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCI-----HTR 1628
Query: 473 GCSPKTKPH 481
C P K H
Sbjct: 1629 SCKPVAKRH 1637
Score = 58.9 bits (141), Expect = 1e-08
Identities = 51/224 (22%), Positives = 84/224 (37%), Gaps = 32/224 (14%)
Query: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVA---DQYCHYYPENIKPKPKLQECNL 356
+W ++ C+ TCG G + C + R V H E + P P +
Sbjct: 481 KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEK 540
Query: 357 DPCPASDGY----KQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSC-VEEDIQGH 411
P A + +++ + P + PW+ACS++CG G+Q R V C V
Sbjct: 541 SPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQT 600
Query: 412 VTSVEEWKCMYTPKMPIAQPCNIFDCPK--------------------WLAQEWSPCTVT 451
T + E +C PK+P +PC + C + W ++PCT T
Sbjct: 601 ETELPEEEC-EGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTAT 659
Query: 452 CGQGLRYRVVLCIDHRGMHTGG---CSPKTKPHIKEECIVPTPC 492
C G + + +C+ + T C +P + PC
Sbjct: 660 CVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPC 703
Score = 54.3 bits (129), Expect = 3e-07
Identities = 38/143 (26%), Positives = 54/143 (37%), Gaps = 27/143 (18%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRV---VADQYCHYYPENIKPKPKLQE-CNL 356
W ++ CS TCGGG Q C L ++ ++D+ C PK + C
Sbjct: 763 WHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQ------GPKASSHKSCAR 816
Query: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
CP P W+ CS SCG GIQ R C +G +
Sbjct: 817 TDCP-----------------PHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLS 859
Query: 417 EWKCMYTPKMPIAQPCNIFDCPK 439
E C P +P+ + C + +C K
Sbjct: 860 EMMCRDLPGLPLVRSCQMPECSK 882
Score = 41.6 bits (96), Expect = 0.002
Identities = 21/65 (32%), Positives = 30/65 (46%), Gaps = 12/65 (18%)
Query: 42 WSECSRTCGGGASYSLRRC-----------LSSKSCEG-RNIRYRTCSNVDCPPEAGDFR 89
W +CSRTCGGG C LS + C+G + +++C+ DCPP
Sbjct: 768 WQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGD 827
Query: 90 AQQCS 94
+CS
Sbjct: 828 WSKCS 832
Score = 36.6 bits (83), Expect = 0.058
Identities = 14/38 (36%), Positives = 21/38 (55%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYC 338
W + PC+A CG G+Q +C RS + VA ++C
Sbjct: 1601 WHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHC 1638
Score = 31.2 bits (69), Expect = 2.4
Identities = 20/63 (31%), Positives = 25/63 (39%), Gaps = 8/63 (12%)
Query: 40 GPWSECSRTCGGGASYSLRRCL-------SSKSC-EGRNIRYRTCSNVDCPPEAGDFRAQ 91
G W CS TCG G CL + C + + + C+ DCPP Q
Sbjct: 710 GSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQ 769
Query: 92 QCS 94
QCS
Sbjct: 770 QCS 772
Score = 30.8 bits (68), Expect = 3.2
Identities = 15/58 (25%), Positives = 23/58 (39%), Gaps = 10/58 (17%)
Query: 40 GPWSECSRTCGGGASYSLRRCLSSKSC----------EGRNIRYRTCSNVDCPPEAGD 87
GPW C+ CG G C+ ++SC + + I +R C C + D
Sbjct: 1604 GPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSCDRDCTD 1661
Score = 29.6 bits (65), Expect = 7.1
Identities = 23/89 (25%), Positives = 39/89 (43%), Gaps = 16/89 (17%)
Query: 6 RATPGTLLLFLA----FLLLSSRTARSEEDRDG-------LWDAWGPWSECSRTCGG-GA 53
R P + ++FL ++L ++ T + D G W+ G WS CS TCG GA
Sbjct: 1387 RRWPESRIVFLQGHKKYILQATNTRTNSNDPTGEPPPQEPFWEP-GNWSHCSATCGHLGA 1445
Query: 54 SYSLRRCLSSKSCEGRNIRYRTCSNVDCP 82
+C+ + G+ + C ++ P
Sbjct: 1446 RIQRPQCVMA---NGQEVSEALCDHLQKP 1471
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 284 bits (726), Expect = 2e-76
Identities = 173/485 (35%), Positives = 236/485 (48%), Gaps = 59/485 (12%)
Query: 30 EDRDGLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPP 83
E DG W W PW +CSRTCGGG S S R C + K C G R+R+C+ DCPP
Sbjct: 544 EGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPP 603
Query: 84 EAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTR 143
+ DFR QCS + + G+FY+W CSL C A+G E A V+DGT
Sbjct: 604 GSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTP 663
Query: 144 CYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDD 203
C +++D+C+SG C+ VGCD LGS ++ED C VC GDGS C + G + S S +
Sbjct: 664 CRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVF-SPASPGAGYE 722
Query: 204 TVVAIPYGSRHI----------RLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSS 253
VV IP GS HI L LKG D L + L GT + L GT +
Sbjct: 723 DVVWIPKGSVHIFIQDLNLSLSHLALKG-DQESLLLEGLPGTPQPHRLPLAGT------T 775
Query: 254 VDFQKFPDK-EILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPII------HRWRETDF 306
++ PD+ + L GP+ A IV + + + +++ F PI + W +
Sbjct: 776 FQLRQGPDQVQSLEALGPINASLIVMVL-ARTELPALRYRFNAPIARDSLPPYSWHYAPW 834
Query: 307 FPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE-CNLDPCPASDGY 365
CSA C GG Q+ + EC + + VA YC + + PK Q CN +PCP
Sbjct: 835 TKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSK----LPKRQRACNTEPCP----- 885
Query: 366 KQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPK 425
P W W+ CS SC G++SR+V C ++++ C P+
Sbjct: 886 ------------PDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACP-QPR 932
Query: 426 MPIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLC--IDHRG-MHTGGCSPKTKPH 481
P+ + C+ C P+W A +WS CT +CG GLR+RVVLC DHR + CSP KP
Sbjct: 933 PPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPP 992
Query: 482 IKEEC 486
C
Sbjct: 993 ATMRC 997
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 275 bits (704), Expect = 6e-74
Identities = 165/486 (33%), Positives = 235/486 (48%), Gaps = 63/486 (12%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAG 86
DG W W W ECSRTCGGG S SLR C S K C G RYR+C+ CP +
Sbjct: 558 DGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSR 617
Query: 87 DFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYT 146
DFR +QC+ +++ G++Y W P + PC+L C A+G E AP V+DGT+C
Sbjct: 618 DFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNA 677
Query: 147 ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVV 206
+SLD+CI+G C+ VGCD+ LGS +ED C VC GDGSTC + G + L + VV
Sbjct: 678 DSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYME-VV 736
Query: 207 AIPYGSRHIRLVLKGPDHLYLETKTLQG----TKGENSLSSTGTFLVDNSSVDFQKFPDK 262
IP GS HI + Y+ K+ +G G ++ F V ++ +++ D+
Sbjct: 737 QIPRGSVHIEVREVAMSKNYIALKS-EGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDE 795
Query: 263 -EILRMAGPLTADFI-----------------VKIRNSGSADSTVQFIFYQPIIHRWRET 304
E L GP + + I V I +GS D+ V F W
Sbjct: 796 PESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGF--------TWNHQ 847
Query: 305 DFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDG 364
+ CSATC GG Q C L N +V + YC P++ KP + CN +PCP
Sbjct: 848 PWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCD--PDS-KPPENQRACNTEPCP---- 900
Query: 365 YKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTP 424
P W W CS +C GG+++RAV C+ + +++ C+ T
Sbjct: 901 -------------PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCL-TH 946
Query: 425 KMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCID---HRGMHTGGCSPKTKP 480
+ +PCN C P+W+A +WS CT CG G ++R+VLC + C ++KP
Sbjct: 947 RPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKP 1006
Query: 481 HIKEEC 486
++ C
Sbjct: 1007 PVRIRC 1012
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 259 bits (663), Expect = 3e-69
Identities = 161/491 (32%), Positives = 229/491 (46%), Gaps = 60/491 (12%)
Query: 13 LLFLAFLLLSSRTARSEEDRDGLWDAWGPWSE---CSRTCGGGASYSLRRCLSSK----- 64
LL L LLL+ S D WGPWS+ CSRTCGGG S+ R C S +
Sbjct: 3 LLLLVPLLLAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGS 62
Query: 65 SCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQ 124
SC G +R+C CP A DFRA+QC+ + + G+ Y WLP + P N C L C
Sbjct: 63 SCVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAP-NKCELNCI 121
Query: 125 AKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGST 184
KG + V+DGT C D+C+ G C++VGCDH+L S+ +ED C C GDG+T
Sbjct: 122 PKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTT 181
Query: 185 CRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSST 244
C V G + + +++ V Y + H + + +L +
Sbjct: 182 CYPVAGTFDAN-DLSRAVKNVRGEYYLNGHWTI------------------EAARALPAA 222
Query: 245 GTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIH----- 299
T L + P++ L GP + ++++ S + V + ++ P+
Sbjct: 223 STILHYERGAEGDLAPER--LHARGPTSEPLVIEL-ISQEPNPGVHYEYHLPLRRPSPGF 279
Query: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
W + CSA CGGG+Q C + D C P +P + + CNL PC
Sbjct: 280 SWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQRQP---RPADR-RSCNLHPC 333
Query: 360 PASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
P + RW+A PW CS+SCGGG QSR+V C+ D G +VEE +
Sbjct: 334 PET---------------KRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAE 378
Query: 420 CMYTP-KMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSP 476
C P K P Q CN+ C W + W C+V+CG G+R R V C RG +HT CS
Sbjct: 379 CAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSL 438
Query: 477 KTKPHIKEECI 487
+ +P + E C+
Sbjct: 439 EDRPPLTEPCV 449
Score = 93.2 bits (230), Expect = 5e-19
Identities = 65/210 (30%), Positives = 85/210 (40%), Gaps = 35/210 (16%)
Query: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRS---NRVVADQYCHYYPENIKPKPKLQ 352
P RW+ + PCSA+CGGG Q S C V + C P KP P +Q
Sbjct: 334 PETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPG--KP-PAIQ 390
Query: 353 ECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHV 412
CNL C A W PW CS SCG G++ R+V+C E
Sbjct: 391 ACNLQRCAA------------------WSPEPWGECSVSCGVGVRKRSVTCRGE----RG 428
Query: 413 TSVEEWKCMYTPKMPIAQPCNIFDCP-----KWLAQEWSPCTVTCGQGLRYRVVLCIDHR 467
+ + C + P+ +PC DCP W W C+ +C G R R V+C
Sbjct: 429 SLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGP 488
Query: 468 GMHTGGCSPKTKPHIKEECIVPTPCYKPKE 497
H G +KP E C PC+ P+E
Sbjct: 489 PSHCGSLQ-HSKPVDVEPCNT-QPCHLPQE 516
Score = 33.5 bits (75), Expect = 0.49
Identities = 37/154 (24%), Positives = 56/154 (36%), Gaps = 20/154 (12%)
Query: 356 LDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV 415
L P P S K D + P W + W+ CS +CGGG+ R C + G + V
Sbjct: 11 LAPAPGSSAPKVRRQSDTWGP---W--SQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCV 65
Query: 416 EEWKCMYTPKMPIAQPCNIFDCP----KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHT 471
+ + C CP + A++ + QG RYR +
Sbjct: 66 GPARS--------HRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCE 117
Query: 472 GGCSPKTKPHI---KEECIVPTPCYKPKEKLPVE 502
C PK + +E + TPC K + V+
Sbjct: 118 LNCIPKGENFYYKHREAVVDGTPCEPGKRDVCVD 151
Score = 32.7 bits (73), Expect = 0.83
Identities = 20/67 (29%), Positives = 28/67 (41%), Gaps = 5/67 (7%)
Query: 38 AWGP--WSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSA 95
AW P W ECS +CG G +R ++ + G + CS D PP + C
Sbjct: 399 AWSPEPWGECSVSCGVGVR---KRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPL 455
Query: 96 HNDVKHH 102
+D H
Sbjct: 456 LSDQAWH 462
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 256 bits (654), Expect = 4e-68
Identities = 161/499 (32%), Positives = 237/499 (47%), Gaps = 62/499 (12%)
Query: 22 SSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC----LSSKSCEGRNIRYRTCS 77
+SRT+ E L W WS CSRTC G S R+C ++ C G +YR C
Sbjct: 626 TSRTSAPEH----LAGEWSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICE 681
Query: 78 NVDCPPEAGDFRAQQCSAHN----DVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVE 133
N CP FR QC A++ KH +W V D + PC+L C G +
Sbjct: 682 NPPCPAGLPGFRDWQCQAYSVRTSSPKH---ILQWQAVL-DEEKPCALFCSPVGKEQPIL 737
Query: 134 LAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYK 193
L+ KV+DGT C + LD+C +G CQ VGCD LGS +ED+CGVCNG+G +C++++G +
Sbjct: 738 LSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFN 797
Query: 194 SQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTL--QGTKGENSLSSTGTFLVDN 251
A + V+ IP G+R I++V + P H YL + Q + + +G F +
Sbjct: 798 HTRGAGYVE--VLVIPAGARRIKVVEEKPAHSYLALRDAGKQSINSDWKIEHSGAFNLAG 855
Query: 252 SSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPI-------------- 297
++V + + E + GP TA + + + + + + P
Sbjct: 856 TTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPEP 915
Query: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNR--VVADQYCHYYPENIKPKPKLQECN 355
+ W T + C ATCGGG + T+ C + S +V ++ C Y KP+P++++CN
Sbjct: 916 LFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYL---TKPEPQIRKCN 972
Query: 356 LDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV 415
PC RW T WT CS +CG G+QSR V+C ++ G +
Sbjct: 973 EQPCQT-----------------RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRA 1015
Query: 416 EEWKCMYTPKMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474
E C+ PK AQ C DC W A WS C+V CG+G+R+R V C + R C
Sbjct: 1016 RERDCI-GPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKK----C 1070
Query: 475 SPKTKPHIKEECIVPTPCY 493
T+P E+C + CY
Sbjct: 1071 VLSTRPREAEDCEDYSKCY 1089
Score = 29.6 bits (65), Expect = 7.1
Identities = 16/46 (34%), Positives = 25/46 (54%), Gaps = 5/46 (10%)
Query: 20 LLSSRTARSEEDRDG----LWDAWGPWSECSRTCGGGASYSLRRCL 61
+LS+R +E+ D +W G WS+CS TCG G + +C+
Sbjct: 1071 VLSTRPREAEDCEDYSKCYVW-RMGDWSKCSITCGKGMQSRVIQCM 1115
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 238 bits (606), Expect = 1e-62
Identities = 160/507 (31%), Positives = 226/507 (44%), Gaps = 63/507 (12%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKS------CEGRNIRYRTCSNVDCPPEAGD 87
G W W WS CSRTCGGG S+ R C + K CEG + C++ CP ++ D
Sbjct: 587 GHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVD 646
Query: 88 FRAQQCSAHNDVKHHGQFYEWLPVSNDPDNP-CSLKCQAKGTTLVVELAPKVLDGTRCYT 146
FRA QC+ HN + G+ Y+W P + D C L C A+G L+ KV DGT C
Sbjct: 647 FRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSE 706
Query: 147 ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVV 206
+S ++CI G+C+ VGCD+ LGS ED CGVCNG+ S C + RG Y ++ T +V
Sbjct: 707 DSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLY-TKHHHTNQYYHMV 765
Query: 207 AIPYGSRHIRLVLKGPDHLYLETKTL---QGTKGENSLSSTGTFLVDNSSVDFQK-FPDK 262
IP G+R IR+ Y+ + G ++ G + ++ D+++ + +
Sbjct: 766 TIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEP 825
Query: 263 EILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFP----------CSAT 312
E L GP IV++ G + V + + P + ++ P CS +
Sbjct: 826 ENLIATGPTNETLIVELLFQG-RNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVS 884
Query: 313 CGGGYQLTSAECY-DLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPY 371
CGGG CY DL+ V +C+ +P L C + CP
Sbjct: 885 CGGGQMTVREGCYRDLKFQ--VNMSFCN---PKTRPVTGLVPCKVSACP----------- 928
Query: 372 DLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQP 431
P W W+ACS +CGGG QSR V C + V C P Q
Sbjct: 929 ------PSWSVGNWSACSRTCGGGAQSRPVQCTRR-VHYDSEPVPASLCP-QPAPSSRQA 980
Query: 432 CNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG------MHTGGCSPKTKPHIKE 484
CN C P W A W+ C+ TCG+G R R V C + C+ + KP + E
Sbjct: 981 CNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHE 1040
Query: 485 ECIVPTPCYKPKEKLPVEAKLPWFKQA 511
C++ C+KPK KL W A
Sbjct: 1041 ACLLQR-CHKPK-------KLQWLVSA 1059
Score = 80.9 bits (198), Expect = 3e-15
Identities = 55/205 (26%), Positives = 83/205 (40%), Gaps = 38/205 (18%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSN---RVVADQYCHYYPENIKPKPKLQE-CNL 356
W + CS TCG G++ + C + +++ D C +PKP++ E C L
Sbjct: 990 WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVC-----TSEPKPRMHEACLL 1044
Query: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
C P L +W + W+ CS +C G Q R + C E+ + G +
Sbjct: 1045 QRCHK--------PKKL-----QWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELA 1091
Query: 417 EWKCMYTPK--MPIAQPCNIFDCPK-------------WLAQEWSPCTVTCGQGLRYRVV 461
KC + PK + + + C CP+ W A WS CT +CG G++ R V
Sbjct: 1092 SKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSV 1151
Query: 462 LCIDHRGMHTGGCSPKTKPHIKEEC 486
C+ G GC KP C
Sbjct: 1152 QCL-AGGRPASGCLLHQKPSASLAC 1175
Score = 62.8 bits (151), Expect = 8e-10
Identities = 46/149 (30%), Positives = 67/149 (44%), Gaps = 19/149 (12%)
Query: 294 YQPIIHRWRETDFFPCSATCGGGYQ---LTSAECYDLRSNRVVADQYCHYYPENIKPKPK 350
++P +W + + CS TC G Q L AE Y R +A + C + P KP +
Sbjct: 1048 HKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLP---KPSLE 1104
Query: 351 LQE-CNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQ 409
L+ C PCP + P W A+PW+ C++SCGGG+Q+R+V C+
Sbjct: 1105 LERACAPLPCPRHPPFAAAGP-----SRGSWFASPWSQCTASCGGGVQTRSVQCL---AG 1156
Query: 410 GHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
G S C+ K + CN CP
Sbjct: 1157 GRPAS----GCLLHQKPSASLACNTHFCP 1181
Score = 32.3 bits (72), Expect = 1.1
Identities = 13/29 (44%), Positives = 18/29 (62%), Gaps = 1/29 (3%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLS 62
G W A PWS+C+ +CGGG +CL+
Sbjct: 1128 GSWFA-SPWSQCTASCGGGVQTRSVQCLA 1155
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 236 bits (601), Expect = 5e-62
Identities = 158/502 (31%), Positives = 228/502 (45%), Gaps = 63/502 (12%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKS------CEGRNIRYRTCSNVDCPPEAGD 87
G W AW WSECSRTCGGG + R C + K C G + Y+ C+ C + D
Sbjct: 590 GQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLD 649
Query: 88 FRAQQCSAHNDVKHHGQFYEWLPVSN-DPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYT 146
FRAQQC+ +N G FY+W P + + ++ C L C+A+ ++ KV DGT C
Sbjct: 650 FRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSP 709
Query: 147 ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVV 206
D+CI G+C++VGCDH+LGS D CGVC GD STC+ +G Y +Q A + VV
Sbjct: 710 NKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEY-YPVV 768
Query: 207 AIPYGSRHIRLVLKGPDHLYLETKTLQG---TKGENSLSSTGTFLVDNSSVDFQK-FPDK 262
IP G+R I + YL ++L G S+ G F ++ ++Q+ F
Sbjct: 769 LIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRP 828
Query: 263 EILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPII------------HRWRETDFFPCS 310
E L GP + +I G + + + + P + + W CS
Sbjct: 829 ERLYAPGPTNETLVFEILMQGK-NPGIAWKYALPKVMNGTPPATKRPAYTWSIVQ-SECS 886
Query: 311 ATCGGGYQLTSAECYDLR-SNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIM 369
+CGGGY A C LR N V +C KP + + CN CPA
Sbjct: 887 VSCGGGYINVKAIC--LRDQNTQVNSSFC---SAKTKPVTEPKICNAFSCPA-------- 933
Query: 370 PYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC-MYTPKMPI 428
W W+ CS +C GG QSR + CV++ +V C + TP
Sbjct: 934 ---------YWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQ-- 982
Query: 429 AQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSPKTKPHIKEE 485
Q CN C P+W WS C+ TCG+G+R R +LC + C+ +P ++E
Sbjct: 983 VQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEG 1042
Query: 486 CIVPTPCYKPKEKLPVEAKLPW 507
C++ + P ++L W
Sbjct: 1043 CVL--------GRCPKNSRLQW 1056
Score = 88.6 bits (218), Expect = 1e-17
Identities = 55/199 (27%), Positives = 86/199 (43%), Gaps = 32/199 (16%)
Query: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE-CNLDP 358
+W + CS TCG G + C + + Q P+P+LQE C L
Sbjct: 994 QWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSL------PRPELQEGCVLGR 1047
Query: 359 CPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEW 418
CP + + W A+ W+ CS++CG G++ R + C E+ QG + + E
Sbjct: 1048 CPKNSRLQ-------------WVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPER 1094
Query: 419 KC--MYTPKMPIAQPCNIFDCPK---------WLAQEWSPCTVTCGQGLRYRVVLCIDHR 467
+C + P + + + CN CP W + W CTVTCG G++ R V C+ +
Sbjct: 1095 RCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV-QQ 1153
Query: 468 GMHTGGCSPKTKPHIKEEC 486
G + C KP + C
Sbjct: 1154 GRPSSSCLLHQKPPVLRAC 1172
Score = 69.7 bits (169), Expect = 6e-12
Identities = 46/146 (31%), Positives = 70/146 (47%), Gaps = 29/146 (19%)
Query: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPE----NIKPKPKL---Q 352
+W + + CSATCG G + +C + + +PE NIK KP L +
Sbjct: 1055 QWVASSWSECSATCGLGVRKREMKCSEKGFQGKLIT-----FPERRCRNIK-KPNLDLEE 1108
Query: 353 ECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHV 412
CN CPA + +Y+ + W + PW C+ +CGGG+Q+R+V CV+ QG
Sbjct: 1109 TCNRRACPA---------HPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQ---QGRP 1156
Query: 413 TSVEEWKCMYTPKMPIAQPCNIFDCP 438
+S C+ K P+ + CN CP
Sbjct: 1157 SS----SCLLHQKPPVLRACNTNFCP 1178
Score = 36.6 bits (83), Expect = 0.058
Identities = 20/63 (31%), Positives = 28/63 (44%), Gaps = 8/63 (12%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
W + C+ TCGGG Q S C ++ R + H P P L+ CN + CP
Sbjct: 1127 WYSLPWQQCTVTCGGGVQTRSVHC--VQQGRPSSSCLLHQKP------PVLRACNTNFCP 1178
Query: 361 ASD 363
A +
Sbjct: 1179 APE 1181
Score = 33.9 bits (76), Expect = 0.37
Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 3/43 (6%)
Query: 42 WSECSRTCGGGASYSLRRCLSSKSCEGRNIRY--RTCSNVDCP 82
WSECS TCG G +C S K +G+ I + R C N+ P
Sbjct: 1061 WSECSATCGLGVRKREMKC-SEKGFQGKLITFPERRCRNIKKP 1102
Score = 30.0 bits (66), Expect = 5.4
Identities = 16/48 (33%), Positives = 21/48 (43%), Gaps = 6/48 (12%)
Query: 41 PWSECSRTCGGGASYSLRRCLS----SKSC--EGRNIRYRTCSNVDCP 82
PW +C+ TCGGG C+ S SC + R C+ CP
Sbjct: 1131 PWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCP 1178
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 233 bits (594), Expect = 3e-61
Identities = 165/506 (32%), Positives = 224/506 (44%), Gaps = 77/506 (15%)
Query: 28 SEEDRDGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDC 81
+++ +DG W +W + CSRTCG G + R+C + + C G N Y+ C+ +C
Sbjct: 546 NQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEEC 605
Query: 82 PPEAGDFRAQQCSAHN------DVKHHGQFYEWLPVSN-DPDNPCSLKCQAKGTTLVVEL 134
DFRAQQC N + KHH WLP + DP C L CQ+K T V +
Sbjct: 606 QKHFEDFRAQQCQQRNSHFEYQNTKHH-----WLPYEHPDPKKRCHLYCQSKETGDVAYM 660
Query: 135 APKVLDGTRC-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQY- 192
V DGT C Y + +C+ G C VGCD ++GS ED CGVC GD S CR V+G +
Sbjct: 661 KQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFT 720
Query: 193 --KSQLSATKSDDTVVAIPYGSRHIRLVL-KGPDHLYLETKTLQG---TKGENSLSSTGT 246
+L K D IP G+RH+ + + H+ G G+ + + T
Sbjct: 721 RTPRKLGYLKMFD----IPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRT 776
Query: 247 FLVDNSSVDFQKFPDKEILRMAGPLTADFIVKI---RNSGSADSTVQFIFYQ---PIIH- 299
F+ D+ D E L GPL IV I N + T ++I ++ P I+
Sbjct: 777 FIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINS 836
Query: 300 -----------RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPK 348
W + CS CGGG+Q T C N++V +C N KPK
Sbjct: 837 NNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCE---ANKKPK 893
Query: 349 PKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCG-GGIQSRAVSCVEED 407
P + CN+ C HPL W A W C+ +CG G Q R V C++
Sbjct: 894 PIRRMCNIQECT--------------HPL--WVAEEWEHCTKTCGSSGYQLRTVRCLQPL 937
Query: 408 IQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDH 466
+ G SV CM + +PCN CP +W WS C+VTCG+G R VLC
Sbjct: 938 LDGTNRSVHSKYCM-GDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC--R 994
Query: 467 RGMHTGGCSPKTKPHIKEECIVPTPC 492
G H G KP C +P PC
Sbjct: 995 AGDHCDG----EKPESVRACQLP-PC 1015
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif,
7 preproprotein [Homo sapiens]
Length = 1686
Score = 230 bits (587), Expect = 2e-60
Identities = 152/486 (31%), Positives = 223/486 (45%), Gaps = 60/486 (12%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAG 86
DG W W WS CSR+CG G + R+C + C G R+R C+ CP
Sbjct: 538 DGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRP 597
Query: 87 DFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYT 146
FR QCS + + + GQ + W+PV ND NPC L C+ +L V+DGT CY
Sbjct: 598 SFRHVQCSHFDAMLYKGQLHTWVPVVNDV-NPCELHCRPANEYFAEKLRDAVVDGTPCYQ 656
Query: 147 --ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDT 204
S D+CI+G+C+ VGCD ++ S ED CGVC+G+GSTC V G ++ D
Sbjct: 657 VRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVD-- 714
Query: 205 VVAIPYGSRHIRL--VLKGPDHLYLETKTLQG--TKGENSLSSTGTFLVDNSSVDFQKFP 260
V IP G+R IR+ V + + L L ++ + G ++ G + V ++ + +
Sbjct: 715 VGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRG 774
Query: 261 DKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR--------------WRETDF 306
+ E L GP +++ S + Y+ IHR W +
Sbjct: 775 NWENLTSPGPTKEPVWIQLLFQESNPG----VHYEYTIHREAGGHDEVPPPVFSWHYGPW 830
Query: 307 FPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYK 366
C+ TCG G Q + C + R V +++C +P + ++C+ PCPA
Sbjct: 831 TKCTVTCGRGVQRQNVYCLE-RQAGPVDEEHCDPLG---RPDDQQRKCSEQPCPA----- 881
Query: 367 QIMPYDLYHPLPRWEATPWTACSSSCG-GGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPK 425
RW A W CSSSCG GG+ RAV C+ +++E C + P+
Sbjct: 882 ------------RWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPR 929
Query: 426 MPIAQPCN-IFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIK 483
P PCN CP W WS C+VTCG+G + R VLC + G+ C +P +
Sbjct: 930 PPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGV---PCDEAQQPASE 986
Query: 484 EECIVP 489
C +P
Sbjct: 987 VTCSLP 992
Score = 85.9 bits (211), Expect = 8e-17
Identities = 46/165 (27%), Positives = 69/165 (41%), Gaps = 32/165 (19%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
W ++ CS +CGGG + +C D R R + +C P KP P + C PC
Sbjct: 1466 WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQ--PGPAKP-PAHRPCGAQPCL 1522
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
+ W + W CS +CGGG Q R V+C E + C
Sbjct: 1523 S------------------WYTSSWRECSEACGGGEQQRLVTCPEPGL-----------C 1553
Query: 421 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCID 465
+ +PCN C +W+ W C+ CG G++ R+V C++
Sbjct: 1554 EEALRPNTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVN 1598
Score = 71.6 bits (174), Expect = 2e-12
Identities = 51/187 (27%), Positives = 72/187 (38%), Gaps = 37/187 (19%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
W+ ++ CS TCG G C R D+ C P +P+P + C+L PC
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGR------DEDCA--PAG-RPQPA-RRCHLRPCA 1464
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
W + W+ CS SCGGG R V CV+ + + + C
Sbjct: 1465 T------------------WHSGNWSKCSRSCGGGSSVRDVQCVD---TRDLRPLRPFHC 1503
Query: 421 MYTP-KMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTK 479
P K P +PC C W W C+ CG G + R+V C + G C +
Sbjct: 1504 QPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCPE-----PGLCEEALR 1558
Query: 480 PHIKEEC 486
P+ C
Sbjct: 1559 PNTTRPC 1565
Score = 35.4 bits (80), Expect = 0.13
Identities = 22/62 (35%), Positives = 28/62 (45%), Gaps = 14/62 (22%)
Query: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQ 91
R+ W A G WSECS TCG GA + RC S + + DC P A+
Sbjct: 1411 RNAGWQA-GNWSECSTTCGLGAVWRPVRCSSGR-------------DEDCAPAGRPQPAR 1456
Query: 92 QC 93
+C
Sbjct: 1457 RC 1458
Score = 35.0 bits (79), Expect = 0.17
Identities = 19/55 (34%), Positives = 23/55 (41%), Gaps = 11/55 (20%)
Query: 40 GPWSECSRTCGGGASYSLRRCLS---------SKSC--EGRNIRYRTCSNVDCPP 83
GPW +CS CGGG L +C++ S C E R C DC P
Sbjct: 1576 GPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEP 1630
Score = 33.9 bits (76), Expect = 0.37
Identities = 12/25 (48%), Positives = 19/25 (76%)
Query: 40 GPWSECSRTCGGGASYSLRRCLSSK 64
G WS+CSR+CGGG+S +C+ ++
Sbjct: 1469 GNWSKCSRSCGGGSSVRDVQCVDTR 1493
Score = 30.8 bits (68), Expect = 3.2
Identities = 16/42 (38%), Positives = 17/42 (40%), Gaps = 2/42 (4%)
Query: 42 WSECSRTCGGGASYSLRRCLSSKSCEG--RNIRYRTCSNVDC 81
W ECS CGGG L C CE R R C+ C
Sbjct: 1529 WRECSEACGGGEQQRLVTCPEPGLCEEALRPNTTRPCNTHPC 1570
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
Length = 1095
Score = 226 bits (575), Expect = 5e-59
Identities = 152/497 (30%), Positives = 217/497 (43%), Gaps = 89/497 (17%)
Query: 30 EDRDGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPP 83
E DG W WG WS CSRTCG GA + R+C + C G ++ + C N+ CP
Sbjct: 540 EHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPK 599
Query: 84 EAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTR 143
FR QQC AH+ + + V +D PC L C G + +A +VLDGT
Sbjct: 600 GLPSFRDQQCQAHDRLSPKKKGLLTAVVVDD--KPCELYCSPLGKESPLLVADRVLDGTP 657
Query: 144 CYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQY--------KSQ 195
C D+C+ G CQ +GCD +GS KED CGVC+GDG TC LV+G + K
Sbjct: 658 CGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDS 717
Query: 196 LSATKSDDTVVAIP-----------YGSRHI--RLVLKGPDHLYLETKTLQGTKGENSLS 242
+ + D + +P Y R + ++ KGP L L L + +
Sbjct: 718 GKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIH 777
Query: 243 STGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWR 302
T V N + + Q P+K P + FI W
Sbjct: 778 YEYTVPV-NRTAENQSEPEK-------PQDSLFI------------------------WT 805
Query: 303 ETDFFPCSATCGGGYQLTSAECYDL--RSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
+ + CS CGGG + T C + ++ +V D C P+ +P+P+++ CNL PC
Sbjct: 806 HSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDC---PQASRPEPQVRRCNLHPCQ 862
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
+ RW A PW+ CS++C G Q R V+CV + G + C
Sbjct: 863 S-----------------RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYC 905
Query: 421 MYTPKMPIAQPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTK 479
P+ Q C DC W A EWS C+ +CG+G+ R V C + +G C T+
Sbjct: 906 P-GPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGK----CDASTR 960
Query: 480 PHIKEECIVPTPCYKPK 496
P +E C + CY+ K
Sbjct: 961 PRAEEACEDYSGCYEWK 977
Score = 88.6 bits (218), Expect = 1e-17
Identities = 60/197 (30%), Positives = 85/197 (43%), Gaps = 39/197 (19%)
Query: 296 PIIHRWRETDFFPCSATCGGGYQLTSAEC-YDLRSNRVVADQ--YCHYYPENIKPKP-KL 351
P RW + PCSATC G+Q C Y L++ VA + YC P+P +
Sbjct: 860 PCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCP------GPRPAAV 913
Query: 352 QECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH 411
Q C C L WEA+ W+ CS+SCG G+ R V+C
Sbjct: 914 QSCEGQDC-----------------LSIWEASEWSQCSASCGKGVWKRTVACTN------ 950
Query: 412 VTSVEEWKCMYTPKMPIAQPCNIFD-CPKWLAQEWSPCTVTCGQGLRYRVVLCIDH-RGM 469
+ KC + + + C + C +W +WS C+ TCG+GL+ RVV C+ G
Sbjct: 951 ----SQGKCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGR 1006
Query: 470 HTGGCSPKTKPHIKEEC 486
H C +KP +C
Sbjct: 1007 HGSECPALSKPAPYRQC 1023
Score = 30.0 bits (66), Expect = 5.4
Identities = 15/40 (37%), Positives = 21/40 (52%), Gaps = 3/40 (7%)
Query: 24 RTARSEEDRDGLWDAW--GPWSECSRTCGGGASYSLRRCL 61
R + ED G ++ W G WS CS TCG G + +C+
Sbjct: 962 RAEEACEDYSGCYE-WKTGDWSTCSSTCGKGLQSRVVQCM 1000
Score = 30.0 bits (66), Expect = 5.4
Identities = 17/61 (27%), Positives = 27/61 (44%), Gaps = 6/61 (9%)
Query: 299 HRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDP 358
+ W+ D+ CS+TCG G Q +C V ++ P KP P ++C +
Sbjct: 974 YEWKTGDWSTCSSTCGKGLQSRVVQCM-----HKVTGRHGSECPALSKPAP-YRQCYQEV 1027
Query: 359 C 359
C
Sbjct: 1028 C 1028
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 218 bits (554), Expect = 1e-56
Identities = 143/469 (30%), Positives = 213/469 (45%), Gaps = 63/469 (13%)
Query: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEA 85
RDG W AW P+ CSRTCG G + R+C + ++C G ++ CS DCP
Sbjct: 560 RDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSL 619
Query: 86 GDFRAQQCSA------HNDVKHHGQFYEWLPVSN-DPDNPCSLKCQAKGTTLVVELAPKV 138
DFR +QC H D +HH WLP + D C L C+++ T VV + V
Sbjct: 620 ADFREEQCRQWDLYFEHGDAQHH-----WLPHEHRDAKERCHLYCESRETGEVVSMKRMV 674
Query: 139 LDGTRC-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLS 197
DGTRC Y ++ +C+ G C+ VGCD +GS+ +ED CGVC GD S C++V+G + ++
Sbjct: 675 HDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTF-TRSP 733
Query: 198 ATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTK----GENSL-SSTGTFLVDNS 252
+ IP G+RH+ + +L K L+ K EN + +S+ TF+
Sbjct: 734 KKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGV 793
Query: 253 SVDFQKFPDKEILRMAGPLTADFIVKIRNSGS--ADSTVQFIFYQ--------------P 296
+++ +E L+ GPL V + G T +++ ++
Sbjct: 794 EWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDS 853
Query: 297 IIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNL 356
+++ W + PCS CGGG Q T C +++V +C KPK + CN
Sbjct: 854 VVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALS---KPKAIRRACNP 910
Query: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCG-GGIQSRAVSCVEEDIQGHVTSV 415
C P W W CS +CG G+Q R+V C++ SV
Sbjct: 911 QECSQ----------------PVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSV 954
Query: 416 EEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLC 463
C + + C+ CP +W A WS C+VTCG G + R VLC
Sbjct: 955 HAKHC-NDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLC 1002
Score = 45.4 bits (106), Expect = 1e-04
Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 3/60 (5%)
Query: 439 KWLAQEWSPCTVTCGQGLRYRVVLC---IDHRGMHTGGCSPKTKPHIKEECIVPTPCYKP 495
+W ++WSPC+ CG G ++ C +DH+ +H G C+ +KP P C +P
Sbjct: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 215 bits (547), Expect = 9e-56
Identities = 157/540 (29%), Positives = 222/540 (41%), Gaps = 101/540 (18%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLSSKS------CEGRNIRYRTCSNVDCPPEAG 86
+G W W P+S CSRTCGGG + RRC + C GR +++R+C+ CP
Sbjct: 556 NGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQ 615
Query: 87 DFRAQQCS----AHNDVKHHGQFYEWLPVSND--PDNPCSLKCQAKGTTLVVELAPKVLD 140
DFR +QCS H D+ WLP + + C L CQ GT L V D
Sbjct: 616 DFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVED 675
Query: 141 GTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATK 200
GT C TE+ D+C+ G C GCDH L S+ K D CGVC GD S+C+ + G + S+
Sbjct: 676 GTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFN---SSHY 732
Query: 201 SDDTVVAIPYGSRHIRL----VLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDF 256
+ VV IP G+ ++ + PD YL +G + G FL+ S +
Sbjct: 733 GYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEG-----NFLFNGNFLLSTSKKEI 787
Query: 257 QKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFI----FYQPIIH------RWRETDF 306
+ ++ +G A + N + +Q + Y P +H +D
Sbjct: 788 NVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDM 847
Query: 307 FP---------CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLD 357
F C+ C G Q + C + VV+D+ C + P P Q CN D
Sbjct: 848 FTWDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLP---LPSFVTQSCNTD 903
Query: 358 -------------PCPASDGYKQI----MPYDLYH------------------------- 375
GY+ + M Y ++
Sbjct: 904 CELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHG 963
Query: 376 --PLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCN 433
RW + W+ CS SCGGG +SR C+ GH + E C ++ + CN
Sbjct: 964 NCVFTRWHYSEWSQCSRSCGGGERSRESYCMNN--FGHRLADNE--CQELSRV-TRENCN 1018
Query: 434 IFDCPKWLAQEWSPCTVTCGQGLRYRVVLC---IDHRGMHTGGCSPKTKPHIKEECIVPT 490
F CP W A EWS C VTCG+G + R V C +DH + G C+ TKP C + T
Sbjct: 1019 EFSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDH--LSDGFCNSSTKPESLSPCELHT 1076
Score = 114 bits (284), Expect = 3e-25
Identities = 65/192 (33%), Positives = 99/192 (51%), Gaps = 19/192 (9%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
W+ + PC+ TCG GYQ+ +C + ++ V+ D CH E +P + Q C L PC
Sbjct: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECH---EASRPSDR-QSCVLTPCS 1135
Query: 361 -ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
S ++P L + +W WT CS SCG G Q+R VSC D + +E
Sbjct: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC--RDALDRIA--DESY 1191
Query: 420 CMYTPKMPIAQPCNIFDC----PKWLAQEWSPCTVTCGQGLRYRVVLCID-HRGMHTGGC 474
C + P+ P I+DC +W A +WSPC+ +CG G R VLC++ H+ + C
Sbjct: 1192 CAHLPR-----PAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYC 1246
Query: 475 SPKTKPHIKEEC 486
P+ +P +++EC
Sbjct: 1247 DPEVRPLMEQEC 1258
Score = 97.4 bits (241), Expect = 3e-20
Identities = 60/193 (31%), Positives = 84/193 (43%), Gaps = 34/193 (17%)
Query: 299 HRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDP 358
++WR + CS++C GG Q + C D Q Y KP P+LQ+C P
Sbjct: 1306 NQWRTGPWGSCSSSCSGGLQHRAVVCQDENG------QSASYCDAASKP-PELQQCGPGP 1358
Query: 359 CPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEW 418
CP +W W CS +CGGGI+SR V C + Q +E+
Sbjct: 1359 CP------------------QWNYGNWGECSQTCGGGIKSRLVICQFPNGQ----ILEDH 1396
Query: 419 KCMYTPKMPIAQPCNIFDCP---KWLAQEWSPCTVTCGQGLRYRVVLCID--HRGMHTGG 473
C K P C++ CP W + W+ C+ +CG+G +YR V CID R +
Sbjct: 1397 NCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTN 1456
Query: 474 CSPKTKPHIKEEC 486
CS KP + C
Sbjct: 1457 CSQVQKPPTHKAC 1469
Score = 96.3 bits (238), Expect = 6e-20
Identities = 49/164 (29%), Positives = 75/164 (45%), Gaps = 24/164 (14%)
Query: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
+W ++ CS TCGGG + C + +++ D C E + P + +C++ C
Sbjct: 1361 QWNYGNWGECSQTCGGGIKSRLVIC-QFPNGQILEDHNC----EIVNKPPSVIQCHMHAC 1415
Query: 360 PASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
PA W PWT+CS+SCG G + R V C+++ +E+
Sbjct: 1416 PADVS---------------WHQEPWTSCSASCGKGRKYREVFCIDQ----FQRKLEDTN 1456
Query: 420 CMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLC 463
C K P + C CP W A W+ C+VTCG G++ R V C
Sbjct: 1457 CSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYC 1500
Score = 95.9 bits (237), Expect = 8e-20
Identities = 65/212 (30%), Positives = 92/212 (43%), Gaps = 38/212 (17%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
W+ D+ PCSA+CG G C + ++ + + YC PE ++P + QEC+L CP
Sbjct: 1211 WQAGDWSPCSASCGHGKTTRQVLC--MNYHQPIDENYCD--PE-VRPLME-QECSLAACP 1264
Query: 361 ASDGYKQIMPYD---------------------LYHPLPR---WEATPWTACSSSCGGGI 396
+ + P + HP R W PW +CSSSC GG+
Sbjct: 1265 PAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGL 1324
Query: 397 QSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGL 456
Q RAV C +E+ G S C K P Q C CP+W W C+ TCG G+
Sbjct: 1325 QHRAVVCQDEN--GQSASY----CDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGI 1378
Query: 457 RYRVVLCIDHRG--MHTGGCSPKTKPHIKEEC 486
+ R+V+C G + C KP +C
Sbjct: 1379 KSRLVICQFPNGQILEDHNCEIVNKPPSVIQC 1410
Score = 89.0 bits (219), Expect = 1e-17
Identities = 52/199 (26%), Positives = 84/199 (42%), Gaps = 33/199 (16%)
Query: 297 IIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNL 356
+ RW +++ CS +CGGG + + C + +R+ AD C + + CN
Sbjct: 966 VFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRL-ADNECQELSRVTR-----ENCNE 1019
Query: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
CP+ W A+ W+ C +CG G + R V C Q +V +
Sbjct: 1020 FSCPS------------------WAASEWSECLVTCGKGTKQRQVWC-----QLNVDHLS 1056
Query: 417 EWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG---MHTGG 473
+ C + K PC + C W W PCT TCG G + R V C++ +
Sbjct: 1057 DGFCNSSTKPESLSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTE 1116
Query: 474 CSPKTKPHIKEECIVPTPC 492
C ++P ++ C++ TPC
Sbjct: 1117 CHEASRPSDRQSCVL-TPC 1134
Score = 78.2 bits (191), Expect = 2e-14
Identities = 55/235 (23%), Positives = 85/235 (36%), Gaps = 72/235 (30%)
Query: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
+WR + PCS +CG G Q C D +R+ + YC + P
Sbjct: 1155 QWRHGSWTPCSVSCGRGTQARYVSCRD-ALDRIADESYCAHLPR---------------- 1197
Query: 360 PASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
PA +D + P W+A W+ CS+SCG G +R V C+ + ++E
Sbjct: 1198 PAE-------IWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCM-----NYHQPIDENY 1245
Query: 420 CMYTPKMPIAQPCNIFDCP----------------------------------------- 438
C + + Q C++ CP
Sbjct: 1246 CDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRG 1305
Query: 439 -KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPC 492
+W W C+ +C GL++R V+C D G C +KP ++C P PC
Sbjct: 1306 NQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQC-GPGPC 1359
Score = 50.1 bits (118), Expect = 5e-06
Identities = 27/107 (25%), Positives = 47/107 (43%), Gaps = 10/107 (9%)
Query: 388 CSSSCGGGIQSRAVSCVE-EDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDC-------PK 439
C+++CG + R C E + H + + + + P+ ++ C
Sbjct: 1600 CANNCGFSYRQRITYCTEIPSTKKH--KLHRLRPIVYQECPVVPSSQVYQCINSCLHLAT 1657
Query: 440 WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEEC 486
W +WS C+VTCG G+ R V CI G+ + C KP +++C
Sbjct: 1658 WKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKC 1704
Score = 49.3 bits (116), Expect = 9e-06
Identities = 83/370 (22%), Positives = 125/370 (33%), Gaps = 55/370 (14%)
Query: 39 WGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHND 98
+G W ECS+TCGGG L C + G+ + C V+ PP C A D
Sbjct: 1364 YGNWGECSQTCGGGIKSRLVIC---QFPNGQILEDHNCEIVNKPPSVIQCHMHACPA--D 1418
Query: 99 VKHHGQFYEWLPVSNDPDNPCSLKCQAKG----TTLVVELAPKVLDGTRCYTESLDMCIS 154
V H +P CS C KG ++ + L+ T C ++
Sbjct: 1419 VSWH----------QEPWTSCSASC-GKGRKYREVFCIDQFQRKLEDTNC-SQVQKPPTH 1466
Query: 155 GLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRH 214
C+ V C ++ E C V G G R V + K + P R
Sbjct: 1467 KACRSVRCPSWKANSWNE--CSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRR 1524
Query: 215 IRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTAD 274
+Q E + T S + D +I R +
Sbjct: 1525 C-----------WSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTDNQI-RQVNEI--- 1569
Query: 275 FIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVA 334
+ NS + T + P + D C+ CG Y+ C ++ S +
Sbjct: 1570 ----VYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTK--- 1622
Query: 335 DQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGG 394
+ ++P QEC + P+S Y+ I H L W+ W+ CS +CG
Sbjct: 1623 ----KHKLHRLRP-IVYQECPV--VPSSQVYQCI--NSCLH-LATWKVGKWSKCSVTCGI 1672
Query: 395 GIQSRAVSCV 404
GI R V C+
Sbjct: 1673 GIMKRQVKCI 1682
Score = 32.7 bits (73), Expect = 0.83
Identities = 21/63 (33%), Positives = 27/63 (42%), Gaps = 9/63 (14%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSC--EGRNIRYRTCSNVDCPPEA 85
G W A G WS CS +CG G + C++ C E R + + CS CPP
Sbjct: 1209 GEWQA-GDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAH 1267
Query: 86 GDF 88
F
Sbjct: 1268 SHF 1270
Score = 31.6 bits (70), Expect = 1.9
Identities = 18/54 (33%), Positives = 24/54 (44%), Gaps = 10/54 (18%)
Query: 40 GPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQC 93
GPW CS +C GG + R + + G++ Y C PPE QQC
Sbjct: 1311 GPWGSCSSSCSGGLQH---RAVVCQDENGQSASY--CDAASKPPE-----LQQC 1354
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 214 bits (546), Expect = 1e-55
Identities = 145/485 (29%), Positives = 223/485 (45%), Gaps = 54/485 (11%)
Query: 27 RSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVD 80
+ E G W W PWS CSRTCG G + R C K C G RYR C+
Sbjct: 536 KKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHP 595
Query: 81 CPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLD 140
C EA FR QCS + V + + Y W P+ N P +PC L C+ ++ V+D
Sbjct: 596 CRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFN-PAHPCELYCRPIDGQFSEKMLDAVID 654
Query: 141 GTRCYT--ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSA 198
GT C+ S ++CI+G+C++VGCD+++ S ED CGVC GDGS+C+ VR +K + +
Sbjct: 655 GTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGS 714
Query: 199 TKSDDTVVAIPYGSRHIRLV-LKGPDHLYLETKTLQGTK----GENSLSSTGTFLVDNSS 253
D + IP G+R IR++ ++G + +L ++ K G + G + + +
Sbjct: 715 GYVD--IGLIPKGARDIRVMEIEGAGN-FLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTV 771
Query: 254 VDFQKFPDKEILRMAGP----LTADFIVKIRNSG-SADSTVQFIFYQPIIHR----WRET 304
+ + D E L GP + + ++ N G + T+Q + + W+
Sbjct: 772 FQYDRKGDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYG 831
Query: 305 DFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDG 364
+ CS TCG G + +A C + +V +C PE +P + ++C+ CP
Sbjct: 832 HWTECSVTCGTGIRRQTAHCIK-KGRGMVKATFCD--PET-QPNGRQKKCHEKACP---- 883
Query: 365 YKQIMPYDLYHPLPRWEATPWTACSSSCG-GGIQSRAVSCVEEDIQGHVTSVEEWKCMYT 423
PRW A W ACS++CG G + R V C++ + ++ C +
Sbjct: 884 -------------PRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDE-QALPPTDCQHL 929
Query: 424 PKMPIAQPCN-IFDCPK-WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPH 481
K CN CP W WS C+V+CG G+R R V C + H C KP+
Sbjct: 930 LKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKN---HDEPCDVTRKPN 986
Query: 482 IKEEC 486
+ C
Sbjct: 987 SRALC 991
Score = 94.0 bits (232), Expect = 3e-19
Identities = 57/210 (27%), Positives = 83/210 (39%), Gaps = 38/210 (18%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
W+ ++ CS C GG+++ +C D R +R + +C + P P CN +PC
Sbjct: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGI--PPPLSMSCNPEPCE 1425
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
A W+ PW+ CS SCGGG+Q R V C C
Sbjct: 1426 A------------------WQVEPWSQCSRSCGGGVQERGVFC------------PGGLC 1455
Query: 421 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG-----CS 475
+T + CN C W W C+ +CG G + R V C+ G T C
Sbjct: 1456 DWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCD 1515
Query: 476 PKTKPHIKEECIVPTPCYKPKEKLPVEAKL 505
K +P ++C C K + L + KL
Sbjct: 1516 HKPRPPEFKKC-NQQACKKSADLLCTKDKL 1544
Score = 53.1 bits (126), Expect = 6e-07
Identities = 32/123 (26%), Positives = 48/123 (39%), Gaps = 15/123 (12%)
Query: 375 HPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNI 434
H W W+ CS++CG G R V C ++ + C + A+ C++
Sbjct: 1312 HGSAHWIVGNWSECSTTCGLGAYWRRVEC---------STQMDSDCAAIQRPDPAKRCHL 1362
Query: 435 FDCPKWLAQEWSPCTVTCGQGLRYRVVLCI---DHRGMHTGGCS--PKTKPHIKEECIVP 489
C W WS C+ C G + R + C+ DHR + C P + C P
Sbjct: 1363 RPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSC-NP 1421
Query: 490 TPC 492
PC
Sbjct: 1422 EPC 1424
Score = 34.7 bits (78), Expect = 0.22
Identities = 18/62 (29%), Positives = 26/62 (41%)
Query: 38 AWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHN 97
A G W CS +CGGG +C+ S+ + + C + PPE Q C
Sbjct: 1476 ATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSA 1535
Query: 98 DV 99
D+
Sbjct: 1536 DL 1537
Score = 32.7 bits (73), Expect = 0.83
Identities = 18/54 (33%), Positives = 26/54 (48%), Gaps = 11/54 (20%)
Query: 40 GPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCS---------NVDCPPE 84
G WS+CSR C GG +C+ S+ + RN+R C ++ C PE
Sbjct: 1371 GNWSKCSRNCSGGFKIREIQCVDSR--DHRNLRPFHCQFLAGIPPPLSMSCNPE 1422
Score = 32.3 bits (72), Expect = 1.1
Identities = 12/18 (66%), Positives = 15/18 (83%), Gaps = 2/18 (11%)
Query: 37 DAWG--PWSECSRTCGGG 52
+AW PWS+CSR+CGGG
Sbjct: 1425 EAWQVEPWSQCSRSCGGG 1442
Score = 30.4 bits (67), Expect = 4.1
Identities = 18/50 (36%), Positives = 22/50 (44%)
Query: 11 TLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC 60
T L+ FLL +S + G WSECS TCG GA + C
Sbjct: 1291 TSLITEGFLLNASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVEC 1340
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 213 bits (541), Expect = 5e-55
Identities = 145/499 (29%), Positives = 220/499 (44%), Gaps = 71/499 (14%)
Query: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPPEA 85
+DG W +W + CSR+CGGG R C + C G Y+ C++ +CP
Sbjct: 551 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 610
Query: 86 GDFRAQQCSAHNDVK-HHGQFYEWLPVSNDPD-NPCSLKCQAKGTTLVVELAPKVLDGTR 143
DFRAQQC+ N H + W+P D D C L CQ+ T VV + V DGTR
Sbjct: 611 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTR 670
Query: 144 C-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVR---GQYKSQLSAT 199
C Y + +C G C VGCD ++GS +D CGVC GD S CR V+ G+ Q A
Sbjct: 671 CSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGAL 730
Query: 200 KSDDTVVAIPYGSRHIRL--VLKGPDHLYLETKT----LQGTKGENSLSSTGTFLVDNSS 253
K +V IP G+RHI++ + K P + ++ + + KG+ + S T T +
Sbjct: 731 K----LVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAM----G 782
Query: 254 VDFQKFPD--KEILRMAGPLTADFIV----KIRNSGSADSTVQFIFYQPII--------- 298
++++ + KE L+ +GPL + + +++ ++ ++
Sbjct: 783 LEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVL 842
Query: 299 ------HRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQ 352
+ W + PCS CGGG Q T C R + +V C + +PKP +
Sbjct: 843 LEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDH---KKRPKPIRR 899
Query: 353 ECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGG-GIQSRAVSCVEEDIQGH 411
CN PC P W W ACS SCG G+Q+R + C+ +
Sbjct: 900 RCNQHPCSQ----------------PVWVTEEWGACSRSCGKLGVQTRGIQCL-LPLSNG 942
Query: 412 VTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMH 470
V K + +PC CP +W WS C+ TCG+G++ R V+C +
Sbjct: 943 THKVMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC--RTNAN 1000
Query: 471 TGGCSPKTKPHIKEECIVP 489
+ G +P + C +P
Sbjct: 1001 SLGHCEGDRPDTVQVCSLP 1019
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 213 bits (541), Expect = 5e-55
Identities = 145/499 (29%), Positives = 220/499 (44%), Gaps = 71/499 (14%)
Query: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPPEA 85
+DG W +W + CSR+CGGG R C + C G Y+ C++ +CP
Sbjct: 554 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 613
Query: 86 GDFRAQQCSAHNDVK-HHGQFYEWLPVSNDPD-NPCSLKCQAKGTTLVVELAPKVLDGTR 143
DFRAQQC+ N H + W+P D D C L CQ+ T VV + V DGTR
Sbjct: 614 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTR 673
Query: 144 C-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVR---GQYKSQLSAT 199
C Y + +C G C VGCD ++GS +D CGVC GD S CR V+ G+ Q A
Sbjct: 674 CSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGAL 733
Query: 200 KSDDTVVAIPYGSRHIRL--VLKGPDHLYLETKT----LQGTKGENSLSSTGTFLVDNSS 253
K +V IP G+RHI++ + K P + ++ + + KG+ + S T T +
Sbjct: 734 K----LVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAM----G 785
Query: 254 VDFQKFPD--KEILRMAGPLTADFIV----KIRNSGSADSTVQFIFYQPII--------- 298
++++ + KE L+ +GPL + + +++ ++ ++
Sbjct: 786 LEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVL 845
Query: 299 ------HRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQ 352
+ W + PCS CGGG Q T C R + +V C + +PKP +
Sbjct: 846 LEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDH---KKRPKPIRR 902
Query: 353 ECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGG-GIQSRAVSCVEEDIQGH 411
CN PC P W W ACS SCG G+Q+R + C+ +
Sbjct: 903 RCNQHPCSQ----------------PVWVTEEWGACSRSCGKLGVQTRGIQCL-LPLSNG 945
Query: 412 VTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMH 470
V K + +PC CP +W WS C+ TCG+G++ R V+C +
Sbjct: 946 THKVMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC--RTNAN 1003
Query: 471 TGGCSPKTKPHIKEECIVP 489
+ G +P + C +P
Sbjct: 1004 SLGHCEGDRPDTVQVCSLP 1022
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 202 bits (513), Expect = 8e-52
Identities = 134/442 (30%), Positives = 197/442 (44%), Gaps = 73/442 (16%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAGD 87
G W WGPW +CSRTCGGG Y++R C + K CEG+ +RYR+C+ DCP G
Sbjct: 560 GSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGK 619
Query: 88 -FRAQQCSAHNDVKH----HGQFYEWLP--VSNDPDNPCSLKCQAKGTTLVVELAPKVLD 140
FR +QC AHN+ G EW+P P + C L CQAKG L PKV+D
Sbjct: 620 TFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVD 679
Query: 141 GTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATK 200
GT C +S +C+ G C GCD + S K D CGVC G+GSTC+ + G S SA
Sbjct: 680 GTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISG---SVTSAKP 736
Query: 201 SDDTVVAIPYGSRHIRLVLKGP-----DHLYLETKTLQGT---KGENSLSSTGTFLVDNS 252
++ IP G+ +I + + + +L K GT G+ +LS+ ++
Sbjct: 737 GYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKG 796
Query: 253 SVDFQKFPDK--EILRMAGPLTADFIVKIRNSGSA-DSTVQFIFYQ----------PIIH 299
V E +R PL +++ G+A +++ ++ P
Sbjct: 797 VVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFS 856
Query: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
W ++ CS +C G+Q EC D+
Sbjct: 857 AWVIEEWGECSKSCELGWQRRLVECRDINGQ----------------------------- 887
Query: 360 PASDGYKQIMPYDLY----HPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV 415
PAS+ K++ P HP P+W+ W++CS +CG G + R++ C+ D G V S
Sbjct: 888 PASECAKEVKPASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHD--GGVLSH 945
Query: 416 EEWKCMYTPKMPIAQPCNIFDC 437
E + PK I C + +C
Sbjct: 946 ESCDPLKKPKHFI-DFCTMAEC 966
Score = 71.2 bits (173), Expect = 2e-12
Identities = 40/110 (36%), Positives = 50/110 (45%), Gaps = 9/110 (8%)
Query: 380 WEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK 439
W W CS SC G Q R V C DI G S +C K +PC CP+
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVEC--RDINGQPAS----ECAKEVKPASTRPCADHPCPQ 911
Query: 440 WLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSPKTKP-HIKEEC 486
W EWS C+ TCG+G + R + C+ H G + C P KP H + C
Sbjct: 912 WQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFC 961
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 201 bits (512), Expect = 1e-51
Identities = 157/539 (29%), Positives = 237/539 (43%), Gaps = 102/539 (18%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCL------SSKSCEGRNIRYRTCSNVDCPPEAG 86
DG W +W P+ CSRTCGGG ++R C K C GR +++++C+ C +
Sbjct: 588 DGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKR 647
Query: 87 DFRAQQCSAHNDVKHHG-----QFYEWLPVSND--PDNPCSLKCQAKGTTLVVELAPKVL 139
DFR +QC AH D KH W+P + + C L C+ G T +L +V+
Sbjct: 648 DFRDEQC-AHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVI 706
Query: 140 DGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSAT 199
DGT C ++ D+C+ GLC+ GCDH L S + D CGVC GD S+C+ V G + +
Sbjct: 707 DGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFN---TVH 763
Query: 200 KSDDTVVAIPYGSRHIRLVL-----KGPDHLYLETKTLQGTKGENSLSSTGTFLV----- 249
+TVV IP G+ +I + + D YL L +KGE L+ G F+V
Sbjct: 764 YGYNTVVRIPAGATNIDVRQHSFSGETDDDNYL---ALSSSKGEFLLN--GNFVVTMAKR 818
Query: 250 ----DNSSVDFQKFPDK-EILRMAGPLTADFIVKIRNSGSA-DSTVQFIFYQPIIHR--- 300
N+ V++ E + + + ++++ + G + V++ F PI +
Sbjct: 819 EIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQ 878
Query: 301 --WR-ETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPE-NIKPKPKLQECNL 356
W + CS C G + C V+DQ C P+ +P +C+L
Sbjct: 879 FYWNSHGPWQACSKPC-QGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDL 937
Query: 357 -------DPCPASD--GYKQIMPYDLY---------------------HPLPR------- 379
C A GY+ + D+Y HP P
Sbjct: 938 RWHVASRSECSAQCGLGYRTL---DIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSG 994
Query: 380 ------WEATPWTACSSSCGGGIQSRAVSCV--EEDIQGHVTSVEEWKCMYTPKMPIAQP 431
W + WT CS SC GG Q R CV D+ +++ KC + K+ I Q
Sbjct: 995 ECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDV------LDDSKCTHQEKVTI-QR 1047
Query: 432 CNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLC-IDHRGMHTGGCSPKTKPHIKEECIVP 489
C+ F CP+W + +WS C VTCG+G ++R V C ++ C P+TKP + C P
Sbjct: 1048 CSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQP 1106
Score = 105 bits (262), Expect = 1e-22
Identities = 63/201 (31%), Positives = 93/201 (46%), Gaps = 13/201 (6%)
Query: 295 QPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPK-LQE 353
QP W+ + CS TCG GYQL + +C VV D C N +P Q+
Sbjct: 1105 QPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDC-----NAATRPTDTQD 1159
Query: 354 CNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVT 413
C L C + P +W WT CS++CG G + R VSC +E+ G V
Sbjct: 1160 CELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDEN--GSVA 1217
Query: 414 SVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHT 471
+E C P+ + C++ C +W A +WS C+VTCGQG R V+C+++ +
Sbjct: 1218 --DESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDR 1275
Query: 472 GGCSPKTKPHIKEECIVPTPC 492
C P ++C + +PC
Sbjct: 1276 SECDQDYIPETDQDCSM-SPC 1295
Score = 97.8 bits (242), Expect = 2e-20
Identities = 116/504 (23%), Positives = 170/504 (33%), Gaps = 95/504 (18%)
Query: 22 SSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRCLS--------SKSCEGRNIRY 73
S+R S E G W + W+ECS++C GG C++ SK +
Sbjct: 987 SNREKCSGECNTGGW-RYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTI 1045
Query: 74 RTCSNVDCPP-EAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVV 132
+ CS CP ++GD+ + KH W D N + K T++
Sbjct: 1046 QRCSEFPCPQWKSGDWSECLVTCGKGHKHR---QVWCQFGEDRLNDRMCDPETKPTSMQT 1102
Query: 133 ELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQY 192
P+ C S G C V G G R V+
Sbjct: 1103 CQQPE--------------CASWQAGPWG------------QCSVTCGQGYQLRAVKCII 1136
Query: 193 KSQLSATKSDDTVVAI-PYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDN 251
+ +S +D A P ++ L P ET+ T+
Sbjct: 1137 GTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRR-------------STYSAPR 1183
Query: 252 SSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIH---------RWR 302
+ F + G + N AD + +P+ +W+
Sbjct: 1184 TQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQWK 1243
Query: 303 ETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCH--YYPENIKPKPKLQECNLDPCP 360
D+ CS TCG G C + S+ V+ C Y PE Q+C++ PCP
Sbjct: 1244 ALDWSSCSVTCGQGRATRQVMCVNY-SDHVIDRSECDQDYIPETD------QDCSMSPCP 1296
Query: 361 --ASDGYKQIMPYDLYHPLPR--------------WEATPWTACSSSCGGGIQSRAVSCV 404
D P+ PR W PW ACSS+C GG Q R V C
Sbjct: 1297 QRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQ 1356
Query: 405 EEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCI 464
+E+ G+ + C+ K + C CP+W W CT CG G+R R+V+C
Sbjct: 1357 DEN--GYTAN----DCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQ 1410
Query: 465 DHRGMHTG--GCSPKTKPHIKEEC 486
G C KP +E+C
Sbjct: 1411 RSNGERFPDLSCEILDKPPDREQC 1434
Score = 92.4 bits (228), Expect = 9e-19
Identities = 119/485 (24%), Positives = 165/485 (34%), Gaps = 136/485 (28%)
Query: 36 WDAWGPWSECSRTCGGGASYSLRRCL-----SSKSCEGRNIRYRTCSNVDC-------PP 83
W A GPW +CS TCG G +C+ S N R DC PP
Sbjct: 1111 WQA-GPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPP 1169
Query: 84 EAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTR 143
A + R SA + +F W PCS C KGT +
Sbjct: 1170 AAPETRRSTYSAP---RTQWRFGSW--------TPCSATC-GKGTRMRY---------VS 1208
Query: 144 CYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGV--CNG----DGSTCRLVRGQYKSQLS 197
C E+ + C L V ++ C V C D S+C + GQ +
Sbjct: 1209 CRDENGSVADESACAT------LPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGR---- 1258
Query: 198 ATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQ 257
AT+ V+ + Y DH+ +D S D
Sbjct: 1259 ATRQ---VMCVNYS-----------DHV-----------------------IDRSECDQD 1281
Query: 258 KFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPII-----------HRWRETDF 306
P+ + P + +SG A Q Y+P ++WR +
Sbjct: 1282 YIPETDQDCSMSPCPQ----RTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPW 1337
Query: 307 FPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYK 366
CS+TC GG Q C D N A+ E IKP + + C PC
Sbjct: 1338 GACSSTCAGGSQRRVVVCQD--ENGYTANDCV----ERIKPDEQ-RACESGPC------- 1383
Query: 367 QIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKM 426
P+W W C+ CGGGI++R V C + + + C K
Sbjct: 1384 -----------PQWAYGNWGECTKLCGGGIRTRLVVCQRSNGE----RFPDLSCEILDKP 1428
Query: 427 PIAQPCNIFDCP---KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMH--TGGCSPKTKPH 481
P + CN CP W WS C+V+CG+G + R V C+ G H + C KPH
Sbjct: 1429 PDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPH 1488
Query: 482 IKEEC 486
+C
Sbjct: 1489 GHRKC 1493
Score = 86.7 bits (213), Expect = 5e-17
Identities = 58/198 (29%), Positives = 85/198 (42%), Gaps = 33/198 (16%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
WR + + CS +C GG Q A C + R N V+ D C + + K +Q C+ PCP
Sbjct: 1001 WRYSAWTECSKSCDGGTQRRRAICVNTR-NDVLDDSKCTH-----QEKVTIQRCSEFPCP 1054
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
+W++ W+ C +CG G + R V C Q + + C
Sbjct: 1055 ------------------QWKSGDWSECLVTCGKGHKHRQVWC-----QFGEDRLNDRMC 1091
Query: 421 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHT---GGCSPK 477
K Q C +C W A W C+VTCGQG + R V CI M C+
Sbjct: 1092 DPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAA 1151
Query: 478 TKPHIKEECIVPTPCYKP 495
T+P ++C +P+ C+ P
Sbjct: 1152 TRPTDTQDCELPS-CHPP 1168
Score = 85.1 bits (209), Expect = 1e-16
Identities = 58/196 (29%), Positives = 85/196 (43%), Gaps = 32/196 (16%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
W + CS +CG G++ + C + + +D YC + KP ++C CP
Sbjct: 1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESD-YCKHLA---KPHGH-RKCRGGRCP 1499
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
+W+A W+ CS SCG G+Q R V C I H + E +C
Sbjct: 1500 ------------------KWKAGAWSQCSVSCGRGVQQRHVGC---QIGTHKIA-RETEC 1537
Query: 421 MYTPKMPIAQPCNIFDCP--KWLAQEWSPCTVTCGQGLRYRVVLCID--HRGMHTGGCSP 476
+ + C CP W A+EW CT TCG+G RYR V+C+D +H C
Sbjct: 1538 NPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDV 1597
Query: 477 KTKPHIKEECIVPTPC 492
+P +E C + PC
Sbjct: 1598 SKRPVDRESCSL-QPC 1612
Score = 80.1 bits (196), Expect = 5e-15
Identities = 55/210 (26%), Positives = 82/210 (39%), Gaps = 39/210 (18%)
Query: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE-CNL 356
++ WR ++ C+ TCG G + C D N V H ++ +P +E C+L
Sbjct: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEV------HGARCDVSKRPVDRESCSL 1609
Query: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
PC W W+ CS +CG G + R VSC E T E
Sbjct: 1610 QPCEYV-----------------WITGEWSECSVTCGKGYKQRLVSCSEI-----YTGKE 1647
Query: 417 EWKCMYTPKM-------PIAQPCNIFDCP---KWLAQEWSPCTVTCGQGLRYRVVLCIDH 466
++ Y + P PC + DCP W W C+V+CG G+ R V C+ +
Sbjct: 1648 NYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTN 1707
Query: 467 RGMHTGGCSPKTKPHIKEECIVPTPCYKPK 496
+ C KP ++ C C P+
Sbjct: 1708 EDQPSHLCHTDLKPEERKTCRNVYNCELPQ 1737
Score = 73.6 bits (179), Expect = 4e-13
Identities = 43/165 (26%), Positives = 76/165 (46%), Gaps = 26/165 (15%)
Query: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
+W+ + CS +CG G Q C + ++++ + C+ Y +P+ + ++C C
Sbjct: 1500 KWKAGAWSQCSVSCGRGVQQRHVGC-QIGTHKIARETECNPYT---RPESE-RDCQGPRC 1554
Query: 360 PASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
P L W A W C+ +CG G + R V CV+++ V +
Sbjct: 1555 P----------------LYTWRAEEWQECTKTCGEGSRYRKVVCVDDN----KNEVHGAR 1594
Query: 420 CMYTPKMPIAQPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVVLC 463
C + + + C++ C W+ EWS C+VTCG+G + R+V C
Sbjct: 1595 CDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSC 1639
Score = 55.1 bits (131), Expect = 2e-07
Identities = 34/123 (27%), Positives = 50/123 (40%), Gaps = 23/123 (18%)
Query: 295 QPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIK----PKPK 350
QP + W ++ CS TCG GY+ C ++ + + + Y + Y I P
Sbjct: 1610 QPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGK---ENYEYSYQTTINCPGTQPPS 1666
Query: 351 LQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCV-EEDIQ 409
+ C L CP S W W +CS SCG G+ R+V C+ ED
Sbjct: 1667 VHPCYLRDCPVS---------------ATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQP 1711
Query: 410 GHV 412
H+
Sbjct: 1712 SHL 1714
Score = 33.1 bits (74), Expect = 0.64
Identities = 18/44 (40%), Positives = 23/44 (52%), Gaps = 3/44 (6%)
Query: 40 GPWSECSRTCGGGASYSLRRCLSSKSCEGR-NIRYRTCSNVDCP 82
G WSECS TCG G L C S+ G+ N Y + ++CP
Sbjct: 1619 GEWSECSVTCGKGYKQRLVSC--SEIYTGKENYEYSYQTTINCP 1660
Score = 30.4 bits (67), Expect = 4.1
Identities = 17/61 (27%), Positives = 26/61 (42%), Gaps = 4/61 (6%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQ 92
D W GPWS CS +CG G C++ +G ++ C ++ P R +
Sbjct: 1442 DAAWST-GPWSSCSVSCGRGHKQRNVYCMAK---DGSHLESDYCKHLAKPHGHRKCRGGR 1497
Query: 93 C 93
C
Sbjct: 1498 C 1498
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 193 bits (491), Expect = 3e-49
Identities = 144/484 (29%), Positives = 208/484 (42%), Gaps = 73/484 (15%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAG 86
DG W W P+ CSRTCGGG + R+C + K CEG ++YR+C+ CP A
Sbjct: 516 DGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSAS 575
Query: 87 --DFRAQQCSAHNDVKHHGQ----FYEWLPVSN--DPDNPCSLKCQAKGTTLVVELAPKV 138
FR +QC A N H W+P + P + C L C+A GT LAPKV
Sbjct: 576 GKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKV 635
Query: 139 LDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSA 198
+DGT C +S +C+ G C GCD LGS + D CGVC GD +C+ V G + +
Sbjct: 636 VDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHG 695
Query: 199 TKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQK 258
+ VVAIP G+ I + +G L + L + G F+V S+V+
Sbjct: 696 Y---NFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVV--SAVERDL 750
Query: 259 FPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQ 318
+LR +G +G+A ++Q +PI+ +
Sbjct: 751 VVKGSLLRYSG------------TGTAVESLQAS--RPIL-------------------E 777
Query: 319 LTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIM--------P 370
+ E + +Y Y P+ +P+ DP S + ++ P
Sbjct: 778 PLTVEVLSVGKMTPPRVRYSFYLPK--EPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQP 835
Query: 371 YDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQ 430
D P RW A W CS+SCG G+Q RAV C Q V + C + Q
Sbjct: 836 DD--RPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA-----CDAAHRPVETQ 888
Query: 431 PCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSPKTKPHIKEECIV 488
C CP W WSPC+ +CG+G + R + C+ H G + C+ KP + C++
Sbjct: 889 ACGE-PCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVL 947
Query: 489 PTPC 492
PC
Sbjct: 948 -RPC 950
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 177 bits (449), Expect = 2e-44
Identities = 119/373 (31%), Positives = 167/373 (44%), Gaps = 55/373 (14%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAG 86
DG W WGPW ECSRTCGGG +S R C + C GR +Y++C +CPP+
Sbjct: 526 DGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGK 585
Query: 87 DFRAQQC---SAHNDVKHHGQFYEWLP--VSNDPDNPCSLKCQAKGTTLVVELAPKVLDG 141
FR QQC +A+N G +W+P P + C L C+A+G + KV+DG
Sbjct: 586 SFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDG 645
Query: 142 TRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKS 201
T C E+L +C+ G C GCDH + S K D CGVC G G++CR V G S
Sbjct: 646 TLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSG---SLTPTNYG 702
Query: 202 DDTVVAIPYGSRHI---------------RLVLKGPDHLYLETKTLQGTKGENSLSSTGT 246
+ +V IP G+ +I L LK D YL L + E + GT
Sbjct: 703 YNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGT 762
Query: 247 FLVDNSSV-------DFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFI------- 292
L + S+ F+ P+ +++ F K++ + + V F
Sbjct: 763 ILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKER 822
Query: 293 ----FYQPIIH-RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKP 347
QP++H +W D+ CS+TCG G+Q + EC D S + A PE+ KP
Sbjct: 823 ATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRD-PSGQASATCNKALKPEDAKP 881
Query: 348 KPKLQECNLDPCP 360
C CP
Sbjct: 882 ------CESQLCP 888
Score = 42.4 bits (98), Expect = 0.001
Identities = 17/48 (35%), Positives = 25/48 (52%)
Query: 439 KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEEC 486
+W+ +WS C+ TCG G + R V C D G + C+ KP + C
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPC 882
Score = 39.3 bits (90), Expect = 0.009
Identities = 21/60 (35%), Positives = 26/60 (43%), Gaps = 6/60 (10%)
Query: 379 RWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
+W W+ CSS+CG G Q R V C + Q T C K A+PC CP
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASAT------CNKALKPEDAKPCESQLCP 888
Score = 30.8 bits (68), Expect = 3.2
Identities = 16/55 (29%), Positives = 23/55 (41%), Gaps = 7/55 (12%)
Query: 384 PWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
PW CS +CGGG+Q C + + Q + Y Q C+ +CP
Sbjct: 534 PWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKY-------QSCHTEECP 581
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 164 bits (415), Expect = 2e-40
Identities = 140/510 (27%), Positives = 216/510 (42%), Gaps = 86/510 (16%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPPEAGD 87
G W +WGP S CSR+CGGG R+C ++C G +++ C+ C +
Sbjct: 354 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLE 413
Query: 88 FRAQQCSAHNDVKHHGQ-----FYEW---LPVSNDPDNPCSLKCQAKGTTLVVELAPKVL 139
F +QQC+ + FY W +P S D C C+A G + +++ L
Sbjct: 414 FMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQG-DALCRHMCRAIGESFIMKRGDSFL 472
Query: 140 DGTRCYTE------SLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRG--- 190
DGTRC +L +C+SG C+ GCD ++ S D C VC GD STC +G
Sbjct: 473 DGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFT 532
Query: 191 -----QYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTG 245
+Y + L+ T + +V Y + H L HL + G+ S+S
Sbjct: 533 AGRAREYVTFLTVTPNLTSV----YIANHRPLF----THLAVRIGGRYVVAGKMSISPNT 584
Query: 246 TF--LVDNSSVDFQ------KFPDKEILRMAGPLTADFIVKI-RNSGS-----ADSTVQF 291
T+ L+++ V+++ + P E +R+ GPL D +++ R G + F
Sbjct: 585 TYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITF 644
Query: 292 IFYQPIIHR---WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPK 348
++QP + W PCS +CG G + + C D +V C + +P
Sbjct: 645 TYFQPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQ---GSQQPP 700
Query: 349 PKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDI 408
+ C L+PCP P W + CS+SCGGG++ R V CVE
Sbjct: 701 AWPEACVLEPCP-----------------PYWAVGDFGPCSASCGGGLRERPVRCVE--A 741
Query: 409 QGH-VTSVEEWKCMYTPKMPIA--QPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCI 464
QG + ++ +C + P + CN CP +W E S CT G GL C+
Sbjct: 742 QGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCV 801
Query: 465 DHRGMHTGGCSPKTK--PHIKEECIVPTPC 492
G +P T+ + E+ P PC
Sbjct: 802 PGA---DGLEAPVTEGPGSVDEKLPAPEPC 828
Score = 79.7 bits (195), Expect = 6e-15
Identities = 52/174 (29%), Positives = 76/174 (43%), Gaps = 28/174 (16%)
Query: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSN----RVVADQYCHYYPENIKPKPKL 351
P RW + CS +CG G C ++ D C P +P+P+
Sbjct: 919 PCPARW-QYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLP---RPEPQ- 973
Query: 352 QECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH 411
+ C+L+PCP PRW+ CS+SCG G R+V+CV+ D QG
Sbjct: 974 EACSLEPCP-----------------PRWKVMSLGPCSASCGLGTARRSVACVQLD-QGQ 1015
Query: 412 VTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCI 464
V+E C + + PC I DC +W W C+V+CG G++ R C+
Sbjct: 1016 DVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCL 1069
Score = 63.2 bits (152), Expect = 6e-10
Identities = 46/193 (23%), Positives = 72/193 (37%), Gaps = 28/193 (14%)
Query: 309 CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQI 368
CS +CG G C D V ++ C KP + + C PCPA YK
Sbjct: 873 CSVSCGRGLMELRFLCMDSALRVPVQEELCGLAS---KPGSRREVCQAVPCPARWQYKL- 928
Query: 369 MPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE-EWKCMYTPKMP 427
ACS SCG G+ R + C + + + +C P+
Sbjct: 929 -----------------AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPE 971
Query: 428 IAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCID-HRG----MHTGGCSPKTKPH 481
+ C++ CP +W PC+ +CG G R V C+ +G + C+ +P
Sbjct: 972 PQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE 1031
Query: 482 IKEECIVPTPCYK 494
C++ Y+
Sbjct: 1032 ASVPCLIADCTYR 1044
Score = 48.5 bits (114), Expect = 1e-05
Identities = 37/138 (26%), Positives = 50/138 (36%), Gaps = 22/138 (15%)
Query: 295 QPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQEC 354
+P RW+ PCSA+CG G S C L + V E
Sbjct: 979 EPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDV-------------------EV 1019
Query: 355 NLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTS 414
+ C A + +P + RW W CS SCG GIQ R +C+ Q V +
Sbjct: 1020 DEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPA 1079
Query: 415 VEEWKCMYTPKMPIAQPC 432
C + PK + C
Sbjct: 1080 D---FCQHLPKPVTVRGC 1094
Score = 46.2 bits (108), Expect = 7e-05
Identities = 51/219 (23%), Positives = 80/219 (36%), Gaps = 29/219 (13%)
Query: 295 QPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPK-PKLQE 353
QP RW ++ C++ G G L + C + P ++ K P +
Sbjct: 771 QPCPARWEVSEPSSCTSAGGAGLALENETCVPGADG---LEAPVTEGPGSVDEKLPAPEP 827
Query: 354 CNLDPCPASDGYKQIMPYDLYHPLPRW--------EATPWT----ACSSSCGGGIQSRAV 401
C CP G+ P P W A WT +CS SCG G+
Sbjct: 828 CVGMSCPPGWGHLDATSAGEKAPSP-WGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRF 886
Query: 402 SCVEEDIQGHVTSVEEWKCMYTPKM-PIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRV 460
C++ ++ V+E C K + C CP + + C+V+CG+G+ R+
Sbjct: 887 LCMDSALR---VPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRI 943
Query: 461 VLCIDHRGMHTG-------GCSPKTKPHIKEECIVPTPC 492
+ C G G C +P +E C + PC
Sbjct: 944 LYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSL-EPC 981
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 164 bits (415), Expect = 2e-40
Identities = 140/510 (27%), Positives = 216/510 (42%), Gaps = 86/510 (16%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPPEAGD 87
G W +WGP S CSR+CGGG R+C ++C G +++ C+ C +
Sbjct: 385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLE 444
Query: 88 FRAQQCSAHNDVKHHGQ-----FYEW---LPVSNDPDNPCSLKCQAKGTTLVVELAPKVL 139
F +QQC+ + FY W +P S D C C+A G + +++ L
Sbjct: 445 FMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQG-DALCRHMCRAIGESFIMKRGDSFL 503
Query: 140 DGTRCYTE------SLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRG--- 190
DGTRC +L +C+SG C+ GCD ++ S D C VC GD STC +G
Sbjct: 504 DGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFT 563
Query: 191 -----QYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTG 245
+Y + L+ T + +V Y + H L HL + G+ S+S
Sbjct: 564 AGRAREYVTFLTVTPNLTSV----YIANHRPLF----THLAVRIGGRYVVAGKMSISPNT 615
Query: 246 TF--LVDNSSVDFQ------KFPDKEILRMAGPLTADFIVKI-RNSGS-----ADSTVQF 291
T+ L+++ V+++ + P E +R+ GPL D +++ R G + F
Sbjct: 616 TYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITF 675
Query: 292 IFYQPIIHR---WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPK 348
++QP + W PCS +CG G + + C D +V C + +P
Sbjct: 676 TYFQPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQ---GSQQPP 731
Query: 349 PKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDI 408
+ C L+PCP P W + CS+SCGGG++ R V CVE
Sbjct: 732 AWPEACVLEPCP-----------------PYWAVGDFGPCSASCGGGLRERPVRCVE--A 772
Query: 409 QGH-VTSVEEWKCMYTPKMPIA--QPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCI 464
QG + ++ +C + P + CN CP +W E S CT G GL C+
Sbjct: 773 QGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCV 832
Query: 465 DHRGMHTGGCSPKTK--PHIKEECIVPTPC 492
G +P T+ + E+ P PC
Sbjct: 833 PGA---DGLEAPVTEGPGSVDEKLPAPEPC 859
Score = 79.7 bits (195), Expect = 6e-15
Identities = 52/174 (29%), Positives = 76/174 (43%), Gaps = 28/174 (16%)
Query: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSN----RVVADQYCHYYPENIKPKPKL 351
P RW + CS +CG G C ++ D C P +P+P+
Sbjct: 950 PCPARW-QYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLP---RPEPQ- 1004
Query: 352 QECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH 411
+ C+L+PCP PRW+ CS+SCG G R+V+CV+ D QG
Sbjct: 1005 EACSLEPCP-----------------PRWKVMSLGPCSASCGLGTARRSVACVQLD-QGQ 1046
Query: 412 VTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCI 464
V+E C + + PC I DC +W W C+V+CG G++ R C+
Sbjct: 1047 DVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCL 1100
Score = 63.2 bits (152), Expect = 6e-10
Identities = 46/193 (23%), Positives = 72/193 (37%), Gaps = 28/193 (14%)
Query: 309 CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQI 368
CS +CG G C D V ++ C KP + + C PCPA YK
Sbjct: 904 CSVSCGRGLMELRFLCMDSALRVPVQEELCGLAS---KPGSRREVCQAVPCPARWQYKL- 959
Query: 369 MPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE-EWKCMYTPKMP 427
ACS SCG G+ R + C + + + +C P+
Sbjct: 960 -----------------AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPE 1002
Query: 428 IAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCID-HRG----MHTGGCSPKTKPH 481
+ C++ CP +W PC+ +CG G R V C+ +G + C+ +P
Sbjct: 1003 PQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE 1062
Query: 482 IKEECIVPTPCYK 494
C++ Y+
Sbjct: 1063 ASVPCLIADCTYR 1075
Score = 48.5 bits (114), Expect = 1e-05
Identities = 37/138 (26%), Positives = 50/138 (36%), Gaps = 22/138 (15%)
Query: 295 QPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQEC 354
+P RW+ PCSA+CG G S C L + V E
Sbjct: 1010 EPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDV-------------------EV 1050
Query: 355 NLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTS 414
+ C A + +P + RW W CS SCG GIQ R +C+ Q V +
Sbjct: 1051 DEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPA 1110
Query: 415 VEEWKCMYTPKMPIAQPC 432
C + PK + C
Sbjct: 1111 D---FCQHLPKPVTVRGC 1125
Score = 46.2 bits (108), Expect = 7e-05
Identities = 51/219 (23%), Positives = 80/219 (36%), Gaps = 29/219 (13%)
Query: 295 QPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPK-PKLQE 353
QP RW ++ C++ G G L + C + P ++ K P +
Sbjct: 802 QPCPARWEVSEPSSCTSAGGAGLALENETCVPGADG---LEAPVTEGPGSVDEKLPAPEP 858
Query: 354 CNLDPCPASDGYKQIMPYDLYHPLPRW--------EATPWT----ACSSSCGGGIQSRAV 401
C CP G+ P P W A WT +CS SCG G+
Sbjct: 859 CVGMSCPPGWGHLDATSAGEKAPSP-WGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRF 917
Query: 402 SCVEEDIQGHVTSVEEWKCMYTPKM-PIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRV 460
C++ ++ V+E C K + C CP + + C+V+CG+G+ R+
Sbjct: 918 LCMDSALR---VPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRI 974
Query: 461 VLCIDHRGMHTG-------GCSPKTKPHIKEECIVPTPC 492
+ C G G C +P +E C + PC
Sbjct: 975 LYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSL-EPC 1012
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 164 bits (415), Expect = 2e-40
Identities = 140/510 (27%), Positives = 216/510 (42%), Gaps = 86/510 (16%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPPEAGD 87
G W +WGP S CSR+CGGG R+C ++C G +++ C+ C +
Sbjct: 385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLE 444
Query: 88 FRAQQCSAHNDVKHHGQ-----FYEW---LPVSNDPDNPCSLKCQAKGTTLVVELAPKVL 139
F +QQC+ + FY W +P S D C C+A G + +++ L
Sbjct: 445 FMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQG-DALCRHMCRAIGESFIMKRGDSFL 503
Query: 140 DGTRCYTE------SLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRG--- 190
DGTRC +L +C+SG C+ GCD ++ S D C VC GD STC +G
Sbjct: 504 DGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFT 563
Query: 191 -----QYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTG 245
+Y + L+ T + +V Y + H L HL + G+ S+S
Sbjct: 564 AGRAREYVTFLTVTPNLTSV----YIANHRPLF----THLAVRIGGRYVVAGKMSISPNT 615
Query: 246 TF--LVDNSSVDFQ------KFPDKEILRMAGPLTADFIVKI-RNSGS-----ADSTVQF 291
T+ L+++ V+++ + P E +R+ GPL D +++ R G + F
Sbjct: 616 TYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITF 675
Query: 292 IFYQPIIHR---WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPK 348
++QP + W PCS +CG G + + C D +V C + +P
Sbjct: 676 TYFQPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQ---GSQQPP 731
Query: 349 PKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDI 408
+ C L+PCP P W + CS+SCGGG++ R V CVE
Sbjct: 732 AWPEACVLEPCP-----------------PYWAVGDFGPCSASCGGGLRERPVRCVE--A 772
Query: 409 QGH-VTSVEEWKCMYTPKMPIA--QPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCI 464
QG + ++ +C + P + CN CP +W E S CT G GL C+
Sbjct: 773 QGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCV 832
Query: 465 DHRGMHTGGCSPKTK--PHIKEECIVPTPC 492
G +P T+ + E+ P PC
Sbjct: 833 PGA---DGLEAPVTEGPGSVDEKLPAPEPC 859
Score = 79.7 bits (195), Expect = 6e-15
Identities = 52/174 (29%), Positives = 76/174 (43%), Gaps = 28/174 (16%)
Query: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSN----RVVADQYCHYYPENIKPKPKL 351
P RW + CS +CG G C ++ D C P +P+P+
Sbjct: 950 PCPARW-QYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLP---RPEPQ- 1004
Query: 352 QECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH 411
+ C+L+PCP PRW+ CS+SCG G R+V+CV+ D QG
Sbjct: 1005 EACSLEPCP-----------------PRWKVMSLGPCSASCGLGTARRSVACVQLD-QGQ 1046
Query: 412 VTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCI 464
V+E C + + PC I DC +W W C+V+CG G++ R C+
Sbjct: 1047 DVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCL 1100
Score = 63.2 bits (152), Expect = 6e-10
Identities = 46/193 (23%), Positives = 72/193 (37%), Gaps = 28/193 (14%)
Query: 309 CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQI 368
CS +CG G C D V ++ C KP + + C PCPA YK
Sbjct: 904 CSVSCGRGLMELRFLCMDSALRVPVQEELCGLAS---KPGSRREVCQAVPCPARWQYKL- 959
Query: 369 MPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE-EWKCMYTPKMP 427
ACS SCG G+ R + C + + + +C P+
Sbjct: 960 -----------------AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPE 1002
Query: 428 IAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCID-HRG----MHTGGCSPKTKPH 481
+ C++ CP +W PC+ +CG G R V C+ +G + C+ +P
Sbjct: 1003 PQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE 1062
Query: 482 IKEECIVPTPCYK 494
C++ Y+
Sbjct: 1063 ASVPCLIADCTYR 1075
Score = 48.5 bits (114), Expect = 1e-05
Identities = 37/138 (26%), Positives = 50/138 (36%), Gaps = 22/138 (15%)
Query: 295 QPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQEC 354
+P RW+ PCSA+CG G S C L + V E
Sbjct: 1010 EPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDV-------------------EV 1050
Query: 355 NLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTS 414
+ C A + +P + RW W CS SCG GIQ R +C+ Q V +
Sbjct: 1051 DEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPA 1110
Query: 415 VEEWKCMYTPKMPIAQPC 432
C + PK + C
Sbjct: 1111 D---FCQHLPKPVTVRGC 1125
Score = 46.2 bits (108), Expect = 7e-05
Identities = 51/219 (23%), Positives = 80/219 (36%), Gaps = 29/219 (13%)
Query: 295 QPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPK-PKLQE 353
QP RW ++ C++ G G L + C + P ++ K P +
Sbjct: 802 QPCPARWEVSEPSSCTSAGGAGLALENETCVPGADG---LEAPVTEGPGSVDEKLPAPEP 858
Query: 354 CNLDPCPASDGYKQIMPYDLYHPLPRW--------EATPWT----ACSSSCGGGIQSRAV 401
C CP G+ P P W A WT +CS SCG G+
Sbjct: 859 CVGMSCPPGWGHLDATSAGEKAPSP-WGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRF 917
Query: 402 SCVEEDIQGHVTSVEEWKCMYTPKM-PIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRV 460
C++ ++ V+E C K + C CP + + C+V+CG+G+ R+
Sbjct: 918 LCMDSALR---VPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRI 974
Query: 461 VLCIDHRGMHTG-------GCSPKTKPHIKEECIVPTPC 492
+ C G G C +P +E C + PC
Sbjct: 975 LYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSL-EPC 1012
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 159 bits (401), Expect = 8e-39
Identities = 112/348 (32%), Positives = 158/348 (45%), Gaps = 52/348 (14%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAGD 87
G W +WG W +CSR+CGGG ++ R C + + C G+ YR+CS + CPP
Sbjct: 568 GNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKS 627
Query: 88 FRAQQCSAHN----DVKHHGQFYEWLPVSND--PDNPCSLKCQAKGTTLVVELAPKVLDG 141
FR +QC A N D K F EW+P P + C L C+AKGT V +PKV DG
Sbjct: 628 FRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDG 687
Query: 142 TRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKS 201
T C S +C+ G C GCD +GS ++ D CGVC GD S+C + G + + +K
Sbjct: 688 TECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKK---SKG 744
Query: 202 DDTVVAIPYGSRHIRL-VLKGPDH----LYLETKTLQG---TKGENSLSSTGTFLVDNSS 253
VV IP G+ HI++ K D YL K G G+ +S++ T + N +
Sbjct: 745 YTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGT 804
Query: 254 V----------DFQK----FPDKEILRM-------AGPLTA--DFIVKIRNSGSADSTVQ 290
V DF KEIL + PL F V +++ +S
Sbjct: 805 VMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTS 864
Query: 291 FIFYQPIIH----RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVA 334
+ H +W + CS TC G+ + +C D NR +A
Sbjct: 865 HGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQD--GNRKLA 910
Score = 37.0 bits (84), Expect = 0.044
Identities = 15/51 (29%), Positives = 23/51 (45%)
Query: 438 PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIV 488
P+W+ W C+ TC G R V C D GC +P ++C++
Sbjct: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLL 927
Score = 34.3 bits (77), Expect = 0.29
Identities = 12/26 (46%), Positives = 15/26 (57%)
Query: 378 PRWEATPWTACSSSCGGGIQSRAVSC 403
P+W PW ACS +C G +R V C
Sbjct: 877 PQWVTGPWLACSRTCDTGWHTRTVQC 902
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 156 bits (394), Expect = 5e-38
Identities = 100/286 (34%), Positives = 141/286 (49%), Gaps = 26/286 (9%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCL------SSKSCEGRNIRYRTCSNVDCPP-EAG 86
G W WGPW +CSRTCGGG +S R C K CEGR R+R+C+ DCP A
Sbjct: 521 GGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSAL 580
Query: 87 DFRAQQCSAHND----VKHHGQFYEWLP--VSNDPDNPCSLKCQAKGTTLVVELAPKVLD 140
FR +QC+A+N K +W+P P + C L CQA+ L P+V+D
Sbjct: 581 TFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVD 640
Query: 141 GTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATK 200
GT C +S +C+ G C GCD +GS K D C VC GDGS C G ++
Sbjct: 641 GTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFR---KFRY 697
Query: 201 SDDTVVAIPYGSRHIRLVLKG-PDH--LYLETKTLQGT---KGENSLSSTGTFLVDNSSV 254
+ VV IP G+ HI + +G P H +YL K G+ GE +L + T +V +V
Sbjct: 698 GYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAV 757
Query: 255 DFQ---KFPDKEILRMAGPLTADFIVKIRNSGS-ADSTVQFIFYQP 296
+ E L GPL +++ +G+ D+ +++ F+ P
Sbjct: 758 SLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVP 803
Score = 32.3 bits (72), Expect = 1.1
Identities = 17/52 (32%), Positives = 24/52 (46%), Gaps = 8/52 (15%)
Query: 309 CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
CS TCGGG Q +S +C R +YC + + + CN + CP
Sbjct: 532 CSRTCGGGVQFSSRDC--TRPVPRNGGKYCE------GRRTRFRSCNTEDCP 575
Score = 31.2 bits (69), Expect = 2.4
Identities = 16/55 (29%), Positives = 23/55 (41%), Gaps = 7/55 (12%)
Query: 384 PWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
PW CS +CGGG+Q + C + E + + + CN DCP
Sbjct: 528 PWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRF-------RSCNTEDCP 575
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 149 bits (376), Expect = 6e-36
Identities = 121/453 (26%), Positives = 182/453 (40%), Gaps = 70/453 (15%)
Query: 66 CEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSN-DPDNPCSLKCQ 124
C G + + R CS CPPE D RA QC+A N + GQ Y+W P + C L C+
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
Query: 125 AKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGST 184
+G V KV DGT C + D+C++G C GCD LGS + D CGVC GD ST
Sbjct: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
Query: 185 CRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQG---TKGENSL 241
CRLV G + ++ IP G+ +++ P YL + G G ++
Sbjct: 484 CRLVSGNLTDR-GGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAV 542
Query: 242 SSTGTFLVDNSSVDFQKFPDK----EILRMAGPLTAD----FIVKIRNSGSADSTVQFIF 293
G++ + + + P + E L GP T I + N G +F
Sbjct: 543 DPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPG--------VF 594
Query: 294 YQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE 353
YQ +I + + N PE ++ +P L
Sbjct: 595 YQYVI-----------------------SSPPPILENPTPEPPVPQLQPEILRVEPPLAP 631
Query: 354 CNLDPCPASDGYKQI-MPYDLYHPLPR---------WEATPWTACSSSCGGGIQSRAVSC 403
+Q+ +P P PR W+ +ACS+SCG G+ C
Sbjct: 632 APRPARTPGTLQRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLC 691
Query: 404 VEEDIQGHVTSVEEWKCMYTPKMPIA-QPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVV 461
+ + ++E C + P + +PC+ CP W A EW+ C+ +CG G ++R +
Sbjct: 692 ISRE---SGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQL 748
Query: 462 LCIDHRGMHTGG--------CSPKTKPHIKEEC 486
C G GG C +P+I + C
Sbjct: 749 QCRQEFG---GGGSSVPPERCGHLPRPNITQSC 778
Score = 92.0 bits (227), Expect = 1e-18
Identities = 52/169 (30%), Positives = 74/169 (43%), Gaps = 22/169 (13%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
W+ CSA+CG G C S + ++ C +P + C+ PCP
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSC---AAGARPPASPEPCHGTPCP 724
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
P WEA WT+CS SCG G Q R + C ++ G +SV +C
Sbjct: 725 -----------------PYWEAGEWTSCSRSCGPGTQHRQLQC-RQEFGGGGSSVPPERC 766
Query: 421 MYTPKMPIAQPCNIFDCPKW-LAQEWSPCTVTCGQGLRYRVVLCIDHRG 468
+ P+ I Q C + C W + WS C+V CG+G R R V C+ + G
Sbjct: 767 GHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNG 815
Score = 87.0 bits (214), Expect = 4e-17
Identities = 62/204 (30%), Positives = 85/204 (41%), Gaps = 36/204 (17%)
Query: 296 PIIHRWRETDFFP-CSATCGGGYQLTSAECYDLRSNRVVAD----------QYCHYYPEN 344
P W +D+ CSA CG G Q S C L S + Q C P
Sbjct: 840 PCTTAWFHSDWSSKCSAECGTGIQRRSVVC--LGSGAALGPGQGEAGAGTGQSC---PTG 894
Query: 345 IKPKPKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCV 404
+P P ++ C+L PC + RW PW CSS CG G Q R + CV
Sbjct: 895 SRP-PDMRACSLGPCERTW---------------RWYTGPWGECSSECGSGTQRRDIICV 938
Query: 405 EE-DIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVL 462
+ + +VTS C + P+ P QPC C +W + WSPC+ +C G + R V
Sbjct: 939 SKLGTEFNVTSPSN--CSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQ 996
Query: 463 CIDHRGMHTGGCSPKTKPHIKEEC 486
C+ + C P+ +P K C
Sbjct: 997 CLSTNQTLSTRCPPQLRPSRKRPC 1020
Score = 52.0 bits (123), Expect = 1e-06
Identities = 37/140 (26%), Positives = 48/140 (34%), Gaps = 29/140 (20%)
Query: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNR--VVADQYCHYYPENIKPKPKLQECNLD 357
RW + CS+ CG G Q C V + C + P P LQ C
Sbjct: 913 RWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPR----PPALQPCQGQ 968
Query: 358 PCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEE 417
C RW +TPW+ CS SC GG Q+R V C+
Sbjct: 969 ACQ-----------------DRWFSTPWSPCSRSCQGGTQTREVQCLS------TNQTLS 1005
Query: 418 WKCMYTPKMPIAQPCNIFDC 437
+C + +PCN C
Sbjct: 1006 TRCPPQLRPSRKRPCNSQPC 1025
Score = 42.7 bits (99), Expect = 8e-04
Identities = 75/342 (21%), Positives = 123/342 (35%), Gaps = 61/342 (17%)
Query: 36 WDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSA 95
W+A G W+ CSR+CG G + +C G ++ C ++ P + + C
Sbjct: 727 WEA-GEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC-G 784
Query: 96 HNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVV--------ELAPKVLDGTRCYTE 147
H +V P + CS++C + V E++ +
Sbjct: 785 HWEV-------------GSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPP 831
Query: 148 SLDMCISGLCQIV--------GCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSAT 199
S + C G C C + G+ ++ + VC G G+ L GQ ++
Sbjct: 832 SREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSV-VCLGSGAA--LGPGQGEAGAGTG 888
Query: 200 KSDDTVVAIPYGSR--HIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQ 257
+S P GSR +R GP T G GE S S G+ +
Sbjct: 889 QS------CPTGSRPPDMRACSLGPCERTWRWYT--GPWGECS-SECGSGTQRRDIICVS 939
Query: 258 KFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGY 317
K + + P + + +Q Q RW T + PCS +C GG
Sbjct: 940 KLGTE--FNVTSPSNCSHLPR-------PPALQPCQGQACQDRWFSTPWSPCSRSCQGGT 990
Query: 318 QLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
Q +C L +N+ ++ + P ++P K + CN PC
Sbjct: 991 QTREVQC--LSTNQTLSTR----CPPQLRPSRK-RPCNSQPC 1025
Score = 33.9 bits (76), Expect = 0.37
Identities = 11/28 (39%), Positives = 15/28 (53%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRC 60
+G+W W W+ CS+ CG G R C
Sbjct: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTC 71
Score = 33.1 bits (74), Expect = 0.64
Identities = 13/34 (38%), Positives = 17/34 (50%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCE 67
G W+ PWS+CS CG G RC+ + E
Sbjct: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDE 817
Score = 30.4 bits (67), Expect = 4.1
Identities = 11/27 (40%), Positives = 16/27 (59%)
Query: 385 WTACSSSCGGGIQSRAVSCVEEDIQGH 411
W +CS CG G+Q R+ +C +Q H
Sbjct: 53 WASCSQPCGVGVQRRSRTCQLPTVQLH 79
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 149 bits (376), Expect = 6e-36
Identities = 121/453 (26%), Positives = 182/453 (40%), Gaps = 70/453 (15%)
Query: 66 CEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSN-DPDNPCSLKCQ 124
C G + + R CS CPPE D RA QC+A N + GQ Y+W P + C L C+
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
Query: 125 AKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGST 184
+G V KV DGT C + D+C++G C GCD LGS + D CGVC GD ST
Sbjct: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
Query: 185 CRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQG---TKGENSL 241
CRLV G + ++ IP G+ +++ P YL + G G ++
Sbjct: 484 CRLVSGNLTDR-GGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAV 542
Query: 242 SSTGTFLVDNSSVDFQKFPDK----EILRMAGPLTAD----FIVKIRNSGSADSTVQFIF 293
G++ + + + P + E L GP T I + N G +F
Sbjct: 543 DPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPG--------VF 594
Query: 294 YQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE 353
YQ +I + + N PE ++ +P L
Sbjct: 595 YQYVI-----------------------SSPPPILENPTPEPPVPQLQPEILRVEPPLAP 631
Query: 354 CNLDPCPASDGYKQI-MPYDLYHPLPR---------WEATPWTACSSSCGGGIQSRAVSC 403
+Q+ +P P PR W+ +ACS+SCG G+ C
Sbjct: 632 APRPARTPGTLQRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLC 691
Query: 404 VEEDIQGHVTSVEEWKCMYTPKMPIA-QPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVV 461
+ + ++E C + P + +PC+ CP W A EW+ C+ +CG G ++R +
Sbjct: 692 ISRE---SGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQL 748
Query: 462 LCIDHRGMHTGG--------CSPKTKPHIKEEC 486
C G GG C +P+I + C
Sbjct: 749 QCRQEFG---GGGSSVPPERCGHLPRPNITQSC 778
Score = 92.0 bits (227), Expect = 1e-18
Identities = 52/169 (30%), Positives = 74/169 (43%), Gaps = 22/169 (13%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
W+ CSA+CG G C S + ++ C +P + C+ PCP
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSC---AAGARPPASPEPCHGTPCP 724
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
P WEA WT+CS SCG G Q R + C ++ G +SV +C
Sbjct: 725 -----------------PYWEAGEWTSCSRSCGPGTQHRQLQC-RQEFGGGGSSVPPERC 766
Query: 421 MYTPKMPIAQPCNIFDCPKW-LAQEWSPCTVTCGQGLRYRVVLCIDHRG 468
+ P+ I Q C + C W + WS C+V CG+G R R V C+ + G
Sbjct: 767 GHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNG 815
Score = 33.9 bits (76), Expect = 0.37
Identities = 11/28 (39%), Positives = 15/28 (53%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRC 60
+G+W W W+ CS+ CG G R C
Sbjct: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTC 71
Score = 33.5 bits (75), Expect = 0.49
Identities = 21/88 (23%), Positives = 36/88 (40%), Gaps = 15/88 (17%)
Query: 36 WDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSA 95
W+A G W+ CSR+CG G + +C G ++ C ++ P + + C
Sbjct: 727 WEA-GEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC-G 784
Query: 96 HNDVKHHGQFYEWLPVSNDPDNPCSLKC 123
H +V P + CS++C
Sbjct: 785 HWEV-------------GSPWSQCSVRC 799
Score = 33.1 bits (74), Expect = 0.64
Identities = 13/34 (38%), Positives = 17/34 (50%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCE 67
G W+ PWS+CS CG G RC+ + E
Sbjct: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDE 817
Score = 30.4 bits (67), Expect = 4.1
Identities = 11/27 (40%), Positives = 16/27 (59%)
Query: 385 WTACSSSCGGGIQSRAVSCVEEDIQGH 411
W +CS CG G+Q R+ +C +Q H
Sbjct: 53 WASCSQPCGVGVQRRSRTCQLPTVQLH 79
>gi|226442878 ADAMTS-like 5 [Homo sapiens]
Length = 471
Score = 138 bits (348), Expect = 1e-32
Identities = 98/297 (32%), Positives = 138/297 (46%), Gaps = 23/297 (7%)
Query: 12 LLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRCL---SSKSCEG 68
LLLFL LL ++ G W W W+ CS +CG G S RRCL + C G
Sbjct: 16 LLLFLWALLNCGLGVSAQGP--GEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPCWG 73
Query: 69 RNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHG--QFYEWLPVSNDPDNPCSLKCQAK 126
+ YR C DCPP A FR QC+ +N G + Y+W+P P N C L C A+
Sbjct: 74 DSHEYRLCQLPDCPPGAVPFRDLQCALYNGRPVLGTQKTYQWVPFHGAP-NQCDLNCLAE 132
Query: 127 GTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCR 186
G +VLDGT C + +C++G C GCD LGS ED CG C G +C
Sbjct: 133 GHAFYHSFG-RVLDGTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCL 191
Query: 187 LVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSL----- 241
V+ ++ A V IP G+RHIR+ + +HL L G G L
Sbjct: 192 FVQRVFR-DAGAFAGYWNVTLIPEGARHIRVEHRSRNHL-----ALMGGDGRYVLNGHWV 245
Query: 242 -SSTGTFLVDNSSVDFQK-FPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQP 296
S GT+ + V + + +E L+ AGP + D ++++ + ++F F+ P
Sbjct: 246 VSPPGTYEAAGTHVVYTRDTGPQETLQAAGPTSHDLLLQVLLQ-EPNPGIEFEFWLP 301
Score = 30.8 bits (68), Expect = 3.2
Identities = 11/20 (55%), Positives = 14/20 (70%)
Query: 385 WTACSSSCGGGIQSRAVSCV 404
WT CSSSCG G+ R+ C+
Sbjct: 44 WTRCSSSCGRGVSVRSRRCL 63
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 132 bits (332), Expect = 8e-31
Identities = 88/287 (30%), Positives = 131/287 (45%), Gaps = 29/287 (10%)
Query: 36 WDAWGPWSECSRTCGGGASYSLRRCLS----------SKSCEGRNIRYRTCSNVDCPPEA 85
W W W+ CSR+CGGG + R CL +++C G + RY+ C +CPP+
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 86 GDFRAQQCSAHNDVKHHGQFYEWLPVSNDP-----DNPCSLKCQAKGTTLVVELAPKVLD 140
FR +QC + N ++G+ ++W P+ D PC L C +L D
Sbjct: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQR--QLMVPARD 167
Query: 141 GTRC-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSAT 199
GT C T+ +C+SG C+ +GCD L ST D CG+C GDGS+C V G Y+ +A
Sbjct: 168 GTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG-NAH 226
Query: 200 KSDDTVVAIPYGSRHIRLV--LKGPDHLYLETKT-LQGTKGENSLSSTGTFLVDNSSVDF 256
V IP G+R I++V K D L L + G + S F + + V +
Sbjct: 227 LGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKY 286
Query: 257 QKFPDK-----EILRMAGPLTADFIVKI--RNSGSADSTVQFIFYQP 296
++ D E + GP V + +N S T ++ QP
Sbjct: 287 RRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP 333
Score = 89.4 bits (220), Expect = 8e-18
Identities = 60/204 (29%), Positives = 83/204 (40%), Gaps = 27/204 (13%)
Query: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKP-KLQEC 354
P +W +D+ PCS +CG G + C RVV + C ++ KP + C
Sbjct: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYC-KTSDGRVVPESQCQ-----METKPLAIHPC 789
Query: 355 NLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTS 414
CPA W A W C+++CG G++ R V C+E G +
Sbjct: 790 GDKNCPA-----------------HWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQT 831
Query: 415 VEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474
+C K P C C KW WS CT TCG G+R R V C + GC
Sbjct: 832 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDI-VRGC 890
Query: 475 SPKTKPHIKEEC-IVPTPCYKPKE 497
P KP ++ C + P P P +
Sbjct: 891 DPLVKPVGRQACDLQPCPTEPPDD 914
Score = 85.1 bits (209), Expect = 1e-16
Identities = 67/237 (28%), Positives = 93/237 (39%), Gaps = 47/237 (19%)
Query: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYP--ENIKPK--------- 348
RW + + CS TCG GYQ C+ + S + Y E ++P+
Sbjct: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
Query: 349 --PKLQECNLDPCPASDGYKQIMPYD--------LYHPLPR---------------WEAT 383
P+ + C A G + ++ D L P R W +
Sbjct: 685 CGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVS 744
Query: 384 PWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLA 442
W CS SCG G R V C D G V V E +C K PC +CP WLA
Sbjct: 745 DWGPCSGSCGQGRTIRHVYCKTSD--GRV--VPESQCQMETKPLAIHPCGDKNCPAHWLA 800
Query: 443 QEWSPCTVTCGQGLRYRVVLCID---HRGMHTGG--CSPKTKPHIKEECIVPTPCYK 494
Q+W C TCG+G++ R+VLC++ + G C KP + C PC+K
Sbjct: 801 QDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCF-ERPCFK 856
Score = 77.4 bits (189), Expect = 3e-14
Identities = 60/200 (30%), Positives = 85/200 (42%), Gaps = 32/200 (16%)
Query: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRV-VADQYCHYYPENIKPKPKLQECNL 356
++RW+ + PCSATC G A C +R + V V D YC +P+P + C
Sbjct: 565 MYRWKLSSHEPCSATCTTGVMSAYAMC--VRYDGVEVDDSYCDALT---RPEPVHEFCAG 619
Query: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
C PRWE + W+ CS +CG G Q R V C + G +SV
Sbjct: 620 RECQ-----------------PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
Query: 417 EWKC--MYTPKMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQ-GLRYRVVLCIDHRGMHTG 472
C + + C C P+W EWS CT CG+ + R + C + +
Sbjct: 663 SDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL--- 719
Query: 473 GCSPKTKPHIKEECIVPTPC 492
C P T+P ++ C P PC
Sbjct: 720 -CDPNTRPVGEKNCTGP-PC 737
Score = 39.7 bits (91), Expect = 0.007
Identities = 22/58 (37%), Positives = 30/58 (51%), Gaps = 3/58 (5%)
Query: 381 EATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
E T WTACS SCGGG+ S+ C+++ + V C T K Q C + +CP
Sbjct: 52 EWTKWTACSRSCGGGVTSQERHCLQQR-RKSVPGPGNRTCTGTSKR--YQLCRVQECP 106
Score = 37.4 bits (85), Expect = 0.034
Identities = 23/69 (33%), Positives = 30/69 (43%), Gaps = 15/69 (21%)
Query: 42 WSECSRTCGGGASYSLRRC-----------LSSKSCEG----RNIRYRTCSNVDCPPEAG 86
WSECSRTCG G + + RC + S CE R +TC N C P+
Sbjct: 631 WSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWE 690
Query: 87 DFRAQQCSA 95
+C+A
Sbjct: 691 MSEWSECTA 699
Score = 32.3 bits (72), Expect = 1.1
Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 6/57 (10%)
Query: 41 PWSECSRTCGGGASYSLRRCLSS----KSCEG--RNIRYRTCSNVDCPPEAGDFRAQ 91
PWSEC++TCG G +C + C+ + + + C CP E D Q
Sbjct: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQ 917
Score = 30.0 bits (66), Expect = 5.4
Identities = 14/59 (23%), Positives = 22/59 (37%), Gaps = 2/59 (3%)
Query: 436 DCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG--CSPKTKPHIKEECIVPTPC 492
D +W PC+ TC G+ +C+ + G+ C T+P E C
Sbjct: 564 DMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC 622
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.449
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,024,955
Number of Sequences: 37866
Number of extensions: 1206775
Number of successful extensions: 3767
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 2472
Number of HSP's gapped (non-prelim): 595
length of query: 525
length of database: 18,247,518
effective HSP length: 107
effective length of query: 418
effective length of database: 14,195,856
effective search space: 5933867808
effective search space used: 5933867808
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.