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Search of human proteins with 153945728
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153945728 microtubule-associated protein 1B [Homo sapiens]
(2468 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 4881 0.0
gi|95147555 microtubule-associated protein 1A [Homo sapiens] 681 0.0
gi|50428935 BPY2 interacting protein 1 [Homo sapiens] 446 e-124
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 131 9e-30
gi|150170670 piccolo isoform 2 [Homo sapiens] 122 4e-27
gi|150378539 piccolo isoform 1 [Homo sapiens] 122 4e-27
gi|110349719 titin isoform N2-A [Homo sapiens] 115 7e-25
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 112 3e-24
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa... 108 5e-23
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 108 7e-23
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 105 4e-22
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa... 105 4e-22
gi|91982772 mucin 17 [Homo sapiens] 104 9e-22
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 103 2e-21
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 103 2e-21
gi|104526627 triadin [Homo sapiens] 103 3e-21
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 102 5e-21
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 99 4e-20
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 99 4e-20
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 99 7e-20
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 98 1e-19
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens] 94 1e-18
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens] 93 4e-18
gi|239743293 PREDICTED: mucin 12 [Homo sapiens] 92 5e-18
gi|221219020 NYD-SP11 protein [Homo sapiens] 90 3e-17
gi|238624188 diffuse panbronchiolitis critical region 1 protein ... 89 5e-17
gi|38788333 remodeling and spacing factor 1 [Homo sapiens] 87 2e-16
gi|239754668 PREDICTED: mucin 12 [Homo sapiens] 87 2e-16
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 87 3e-16
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 86 3e-16
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 4881 bits (12661), Expect = 0.0
Identities = 2468/2468 (100%), Positives = 2468/2468 (100%)
Query: 1 MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRAIGNIE 60
MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRAIGNIE
Sbjct: 1 MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRAIGNIE 60
Query: 61 LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVPGQKILHHRSDVLETVVLINPSDEAV 120
LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVPGQKILHHRSDVLETVVLINPSDEAV
Sbjct: 61 LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVPGQKILHHRSDVLETVVLINPSDEAV 120
Query: 121 STEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFIEIFTDQEIGELLSTTHP 180
STEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFIEIFTDQEIGELLSTTHP
Sbjct: 121 STEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFIEIFTDQEIGELLSTTHP 180
Query: 181 ANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEMEGLSEFTEYLSESVEVP 240
ANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEMEGLSEFTEYLSESVEVP
Sbjct: 181 ANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEMEGLSEFTEYLSESVEVP 240
Query: 241 SPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNMLINGGSERKSCFWKLIRH 300
SPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNMLINGGSERKSCFWKLIRH
Sbjct: 241 SPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNMLINGGSERKSCFWKLIRH 300
Query: 301 LDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNSDWMKNLISPDLGVVFLN 360
LDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNSDWMKNLISPDLGVVFLN
Sbjct: 301 LDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNSDWMKNLISPDLGVVFLN 360
Query: 361 VPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVGNTIDPVILFQKMGVGKL 420
VPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVGNTIDPVILFQKMGVGKL
Sbjct: 361 VPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVGNTIDPVILFQKMGVGKL 420
Query: 421 EMYVLNPVKSSKEMQYFMQQWTGTNKDKAEFILPNGQEVDLPISYLTSVSSLIVWHPANP 480
EMYVLNPVKSSKEMQYFMQQWTGTNKDKAEFILPNGQEVDLPISYLTSVSSLIVWHPANP
Sbjct: 421 EMYVLNPVKSSKEMQYFMQQWTGTNKDKAEFILPNGQEVDLPISYLTSVSSLIVWHPANP 480
Query: 481 AEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRAD 540
AEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRAD
Sbjct: 481 AEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRAD 540
Query: 541 SRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKP 600
SRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKP
Sbjct: 541 SRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKP 600
Query: 601 SVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEV 660
SVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEV
Sbjct: 601 SVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEV 660
Query: 661 AKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKE 720
AKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKE
Sbjct: 661 AKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKE 720
Query: 721 VKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKG 780
VKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKG
Sbjct: 721 VKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKG 780
Query: 781 KIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDF 840
KIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDF
Sbjct: 781 KIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDF 840
Query: 841 EELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTE 900
EELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTE
Sbjct: 841 EELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTE 900
Query: 901 GEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEE 960
GEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEE
Sbjct: 901 GEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEE 960
Query: 961 HVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEA 1020
HVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEA
Sbjct: 961 HVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEA 1020
Query: 1021 DEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGRE 1080
DEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGRE
Sbjct: 1021 DEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGRE 1080
Query: 1081 PASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPR 1140
PASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPR
Sbjct: 1081 PASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPR 1140
Query: 1141 DVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDY 1200
DVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDY
Sbjct: 1141 DVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDY 1200
Query: 1201 NASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLS 1260
NASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLS
Sbjct: 1201 NASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLS 1260
Query: 1261 PSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEV 1320
PSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEV
Sbjct: 1261 PSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEV 1320
Query: 1321 VSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPM 1380
VSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPM
Sbjct: 1321 VSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPM 1380
Query: 1381 DEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPD 1440
DEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPD
Sbjct: 1381 DEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPD 1440
Query: 1441 QVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDV 1500
QVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDV
Sbjct: 1441 QVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDV 1500
Query: 1501 SPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATS 1560
SPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATS
Sbjct: 1501 SPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATS 1560
Query: 1561 SFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSIS 1620
SFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSIS
Sbjct: 1561 SFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSIS 1620
Query: 1621 PPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHIT 1680
PPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHIT
Sbjct: 1621 PPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHIT 1680
Query: 1681 ENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQ 1740
ENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQ
Sbjct: 1681 ENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQ 1740
Query: 1741 IASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPTF 1800
IASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPTF
Sbjct: 1741 IASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPTF 1800
Query: 1801 SDSTSAVKEKTATCHSSSSPPIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDS 1860
SDSTSAVKEKTATCHSSSSPPIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDS
Sbjct: 1801 SDSTSAVKEKTATCHSSSSPPIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDS 1860
Query: 1861 GGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSG 1920
GGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSG
Sbjct: 1861 GGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSG 1920
Query: 1921 YSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSYDISEKTTSPPEVSGYSYEKTERS 1980
YSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSYDISEKTTSPPEVSGYSYEKTERS
Sbjct: 1921 YSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSYDISEKTTSPPEVSGYSYEKTERS 1980
Query: 1981 RRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTY 2040
RRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTY
Sbjct: 1981 RRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTY 2040
Query: 2041 CYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPS 2100
CYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPS
Sbjct: 2041 CYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPS 2100
Query: 2101 FINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDS 2160
FINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDS
Sbjct: 2101 FINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDS 2160
Query: 2161 DVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMV 2220
DVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMV
Sbjct: 2161 DVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMV 2220
Query: 2221 DPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKES 2280
DPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKES
Sbjct: 2221 DPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKES 2280
Query: 2281 SDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPG 2340
SDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPG
Sbjct: 2281 SDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPG 2340
Query: 2341 TTKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGNDPAAEEPSRA 2400
TTKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGNDPAAEEPSRA
Sbjct: 2341 TTKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGNDPAAEEPSRA 2400
Query: 2401 VLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLASSSTVVMQDES 2460
VLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLASSSTVVMQDES
Sbjct: 2401 VLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLASSSTVVMQDES 2460
Query: 2461 FPACKIEL 2468
FPACKIEL
Sbjct: 2461 FPACKIEL 2468
>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
Length = 2803
Score = 681 bits (1756), Expect = 0.0
Identities = 681/2335 (29%), Positives = 995/2335 (42%), Gaps = 517/2335 (22%)
Query: 223 MEGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNM 282
M+G++EF+EY+SE+V+VPSPFD+LEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFN+
Sbjct: 1 MDGVAEFSEYVSETVDVPSPFDLLEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNI 60
Query: 283 LINGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTN 342
L++GGS+RKSCFWKL+RHLDR+DS+LLTHIG DNLPGIN +LQRK+AELEEEQSQGS++
Sbjct: 61 LVDGGSDRKSCFWKLVRHLDRIDSVLLTHIGADNLPGINGLLQRKVAELEEEQSQGSSSY 120
Query: 343 SDWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSV 402
SDW+KNLISP+LGVVF NVPE L+ P+ + K KRSIEEAC TLQ+LN+L ++ EPL+R V
Sbjct: 121 SDWVKNLISPELGVVFFNVPEKLRLPDASRKAKRSIEEACLTLQHLNRLGIQAEPLYRVV 180
Query: 403 GNTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQWTGTNKDKAEFILPNGQEVDLP 462
NTI+P+ LF KMGVG+L+MYVLNPVK SKEMQ+ MQ+W G +K K +LPNG+E ++
Sbjct: 181 SNTIEPLTLFHKMGVGRLDMYVLNPVKDSKEMQFLMQKWAGNSKAKTGIVLPNGKEAEIS 240
Query: 463 ISYLTSVSSLIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQPLATQKDL- 521
+ YLTS+++L+VW PANP EKI+RVLFPGN+ Q ILEGLEKL+HLDFL+ P+ATQKDL
Sbjct: 241 VPYLTSITALVVWLPANPTEKIVRVLFPGNAPQNKILEGLEKLRHLDFLRYPVATQKDLA 300
Query: 522 TGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKE------SKEETPEVTK-VNHV 574
+G VPT +K +K+KQRADS+ESLK K SK ++E +KE E+ K +
Sbjct: 301 SGAVPTN-LKPSKIKQRADSKESLKATTKTAVSKLAKREEVVEEGAKEARSELAKELAKT 359
Query: 575 EKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAK 634
EK K ES EK K KP + +T E +KAE K K K
Sbjct: 360 EKKAK-ESSEKPPEKPAKPERVKT------------ESSEALKAE---------KRKLIK 397
Query: 635 EKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKP-KKEEVKKEVKKEIKKEEK 693
+K KK K K +E+K+K KKE IKKE K KK+E +KE KK+ KKEEK
Sbjct: 398 DKVGKKHLKEKISKLEEKKDKEKKE---------IKKERKELKKDEGRKEEKKDAKKEEK 448
Query: 694 KEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEI--KKLPKDAKKSSTPLSEAKK 751
+ K+ K E+KK K ++K E +K + K+P K + +K
Sbjct: 449 R------------KDTKPELKKISKPDLKPFTPEVRKTLYKAKVPGRVKIDRSRAIRGEK 496
Query: 752 PAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAA 811
+ +P+ P P +KG +
Sbjct: 497 ELSSEPQTP---------------PAQKGTV----------------------------- 512
Query: 812 AGIAAIGPAKELEAERSL-MSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKET 870
P + R L +SSPEDLT+DFEE+K EE + L E +
Sbjct: 513 -------PLPTISGHRELVLSSPEDLTQDFEEMKREE---------RALLAEQRDTGLGD 556
Query: 871 EPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTP----EELEPVEKQGVDDIEKF 926
+P P ++ +EG +T +G P EE EK+ V ++ +
Sbjct: 557 KPF--------------PLDTAEEGPPSTAIQGTPPSVPGLGQEEHVMKEKELVPEVPE- 601
Query: 927 EDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYI 986
E+ S+ + AETEE ++ E+ ++ + D A+ E++ +
Sbjct: 602 -------EQGSKDRGLDSGAETEEEKDTWEEKKQR------EAERLPDRTEAREESEPEV 648
Query: 987 REKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVM 1046
+E + IEK E E+ EE +++ EDA + E +K E +
Sbjct: 649 KE-----------------DVIEKAELEEMEEVHPSDEEEEDATKAEGFYQKHMQEP--L 689
Query: 1047 AVVDKAAEA-GGAE----------EQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSE 1095
V ++ EA GG E E FL++ T GA E S I DET+PG SE
Sbjct: 690 KVTPRSREAFGGRELGLQGKAPEKETSLFLSSLTTPAGA----TEHVSYIQDETIPGYSE 745
Query: 1096 SEATASDEENREDQPEEFTATSGYTQSTIEI----------SSEP--------------T 1131
+E T SDEE D+PEE A + ST ++ +S+P T
Sbjct: 746 TEQTISDEE-IHDEPEERPAPPRFHTSTYDLPGPEGAGPFEASQPADSAVPATSGKVYGT 804
Query: 1132 PMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYS-----QEYSKPADVTPLNGF 1186
P E++ P ++++ EE S + K S S S A T G
Sbjct: 805 PETELTYPTNIVAAPLAEEEHVSSATSITECDKLSSFATSVAEDQSVASLTAPQTEETGK 864
Query: 1187 SE----------GSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYC----SEVK 1232
S S+T+AT G DY SA TISP SS+EEDK +S + + SE +
Sbjct: 865 SSLLLDTVTSIPSSRTEATQGLDYVPSAGTISPTSSLEEDKGFKSPPCEDFSVTGESEKR 924
Query: 1233 ASTT---LDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVS 1289
L + ++ E + S L +P+ P +L P E
Sbjct: 925 GEIIGKGLSGERAVEEEEEETANVEMSEKLCSQYGTPVFSAP------GHALHPGE---- 974
Query: 1290 AEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLP 1349
P E EE C SP+D T+++ SP S SA HTP++QSP +EKS
Sbjct: 975 ------PALGE-----AEERCLSPDDSTVKMASPPPSGPPSATHTPFHQSPVEEKSE--- 1020
Query: 1350 TEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESA 1409
P F+ +D+ + +R P E E+ + P P E
Sbjct: 1021 ----------PQDFQEADSWGDTKRT-------PGVGKEDAAEETVKP--GP----EEGT 1057
Query: 1410 YESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIK 1469
E S + E+P G G Q+ P + +++ + G+ T PI
Sbjct: 1058 LEKEEKVPPPRSPQAQEAPVNIDEGLTGCTIQLLPAQD--KAIVFEIMEAGEPT--GPI- 1112
Query: 1470 EDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDK 1529
G E + + +P P + +V ++ D+
Sbjct: 1113 --LGAEALPGGLRTLPQEPG-----------KPQKDEVLRY----------------PDR 1143
Query: 1530 SATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDS 1589
S +P D S++ S P P T + P+ + G
Sbjct: 1144 SLSPED------------------AESLSVLSVPSPDTANQEPTPKSPCGL--------- 1176
Query: 1590 LSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEF 1649
TE K+ P + SP+ +S + ++ S+++S+ +
Sbjct: 1177 --------------TEQYLHKDRWP--------EVSPEDTQSLSLSEESPSKETSLDVSS 1214
Query: 1650 GQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP 1709
Q SPE + F + +G H+ + T +P + + + PP +
Sbjct: 1215 KQLSPESLGTLQFGELNLGKEEMG----HLMQAEDTSHHTAPMSVPEPHAATASPPTDGT 1270
Query: 1710 S-YTQDNDLSE------LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLY 1762
+ Y+ D+++ + S ++PS + + P I SP E L+ D S
Sbjct: 1271 TRYSAQTDITDDSLDRKSPASSFSHSTPSGNGKYLPGAITSP-DEHILTP-----DSSFS 1324
Query: 1763 ASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSSSPPI 1822
S S +LE + + + L R S P D K+KT H P
Sbjct: 1325 KSPESLPGPALEDIAIKWEDKVPGLKDRTSEQKKEPEPKDEVLQQKDKTLE-HKEVVEPK 1383
Query: 1823 DAASAEPYGFRASVLFDTMQHHLAL---NRDL--STPGLEKDSGGKTPGD---------F 1868
D A + Q AL RDL LE+ P D
Sbjct: 1384 DTAIYQKDEALHVKNEAVKQQDKALEQKGRDLEQKDTALEQKDKALEPKDKDLEEKDKAL 1443
Query: 1869 SYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKI-ERTTKSP--SDSGYSYET 1925
+ PEE ++ +++D E +K D +++ E+ K P D +
Sbjct: 1444 EQKDKIPEEKDKALEQKDTALEQKDKALEPKDKDLEQKDRVLEQKEKIPEEKDKALDQKV 1503
Query: 1926 IGKTTKTPED--GDYSYEIIEKTTRTPEEGGYSYD----ISEKTTSPPEVSGYSY-EKTE 1978
K PED + +E+T + PE+ + + +SEK E ++ +K E
Sbjct: 1504 RSVEHKAPEDTVAEMKDRDLEQTDKAPEQKHQAQEQKDKVSEKKDQALEQKYWALGQKDE 1563
Query: 1979 RSRRLLDDISNGYDDSEDGGHTLGDPS-----YSYETTEKITSFPE-------------- 2019
+ + + + E D + ++ EK+ + E
Sbjct: 1564 ALEQNIQALEENHQTQEQESLVQEDKTRKPKMLEEKSPEKVKAMEEKLEALLEKTKALGL 1623
Query: 2020 -----SEGYSYETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPS 2074
EG + E K R D ET +P + E +L E SP
Sbjct: 1624 EESLVQEGRAREQEEKYWRGQDVVQEWQET------SPTREEPAGEQKELAPAWEDTSPE 1677
Query: 2075 E------ARQDVDL-----CLVSSCEYK--HPKTELSPSFINPNPLE----WFASEEPTE 2117
+ R+DV L SCE K P EL P+ E F E P +
Sbjct: 1678 QDNRYWRGREDVALEQDTYWRELSCERKVWFPH-ELDGQGARPHYTEERESTFLDEGPDD 1736
Query: 2118 ESEKPLTQSGGAPP------------PPGGKQQGRQCDE--------------------- 2144
E E PL + P P G + R E
Sbjct: 1737 EQEVPLREHATRSPWASDFKDFQESSPQKGLEVERWLAESPVGLPPEEEDKLTRSPFEII 1796
Query: 2145 ----TPPTSVSESAPSQTDSDVP-PETEECPSITADANIDS--EDESETIPTDKTVTYKH 2197
+PP V + PS + P P+ + P + + S D +P D+ +
Sbjct: 1797 SPPASPPEMVGQRVPSAPGQESPIPDPKLMPHMKNEPTTPSWLADIPPWVPKDRPLPPAP 1856
Query: 2198 MDPPPAP----VQDRSPSPRHPDVSMVDPEALAIEQNLGK-------ALKKDLKEKTKTK 2246
+ P P P + +P+P + D A+++ + L KD ++ +
Sbjct: 1857 LSPAPGPPTPAPESHTPAPFSWGTAEYDSVVAAVQEGAAELEGGPYSPLGKDYRKAEGER 1916
Query: 2247 KPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKE-SVEKA------ 2299
+ + ++ +P K S P A+ E ++ R +P E S + A
Sbjct: 1917 E--EEGRAEAPDKSSHSSKVPEASKSHATTEPEQTEPEQREPTPYPDERSFQYADIYEQM 1974
Query: 2300 -------AKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKS 2347
A PT P + AA TK AA A + SA+ + P + K+ +S
Sbjct: 1975 MLTGLGPACPTREPPLGAAGDWPPCLSTKEAA-AGRNTSAEKELSSPISPKSLQS 2028
Score = 322 bits (824), Expect = 4e-87
Identities = 201/409 (49%), Positives = 248/409 (60%), Gaps = 43/409 (10%)
Query: 2073 PSEARQDVDLCLVSSCEYKHP-KTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPP 2131
PS A +V+ P + ELSPSF+NP PL + E L GG
Sbjct: 2423 PSSASPEVEAGPQGCATEPRPHRGELSPSFLNP-PLPPSIDDRDLSTEEVRLVGRGGRRR 2481
Query: 2132 PPGGKQQGRQC---DETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIP 2188
G G C DETPPTS S+S SQ+DSDVPPETEECPSITA+A +DS+++ + +P
Sbjct: 2482 VGGPGTTGGPCPVTDETPPTSASDSGSSQSDSDVPPETEECPSITAEAALDSDEDGDFLP 2541
Query: 2189 TDKT--VTYKHM-----DPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKAL--KKDL 2239
DK V+ H DPPP P D PSP PDV M DPE L+ E + L K+ +
Sbjct: 2542 VDKAGGVSGTHHPRPGHDPPPLPQPDPRPSPPRPDVCMADPEGLSSESGRVERLREKEKV 2601
Query: 2240 KEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKA 2299
+ + + PG K K +SP ++ D + K SP P K +D+ SR A P+ +
Sbjct: 2602 QGRVGRRAPG-KAKPASPARRLDLRGK---RSPTPG--KGPADRASR-APPRPR------ 2648
Query: 2300 AKPTTTPEVKAARGEEKDKETKNAANASASKSAKTAT-AGPGTTKTTKSSAVPPGLPVYL 2358
+TT +V A EEKD ++ SK AGP + SS G PVY+
Sbjct: 2649 ---STTSQVTPA--EEKD------GHSPMSKGLVNGLKAGPMALSSKGSS----GAPVYV 2693
Query: 2359 DLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGNDPAAEEPSRAVLDALLEGKAQWGSNMQV 2418
DL YIPNH + K D++FF+RVR+SYYVVSGNDPA EPSRAVLDALLEGKAQWG N+QV
Sbjct: 2694 DLAYIPNHCSGKTADLDFFRRVRASYYVVSGNDPANGEPSRAVLDALLEGKAQWGENLQV 2753
Query: 2419 TLIPTHDSEVMREWYQETHEKQQDLNIMVLASSSTVVMQDESFPACKIE 2467
TLIPTHD+EV REWYQ+THE+QQ LN++VLASSSTVVMQDESFPACKIE
Sbjct: 2754 TLIPTHDTEVTREWYQQTHEQQQQLNVLVLASSSTVVMQDESFPACKIE 2802
Score = 67.0 bits (162), Expect = 2e-10
Identities = 282/1270 (22%), Positives = 467/1270 (36%), Gaps = 279/1270 (21%)
Query: 590 KDKPIKTETK-PSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPED 648
+D IK E K P + ++ K+EP P K EV ++ K+KT++ + V+P+D
Sbjct: 1336 EDIAIKWEDKVPGLKDRTSEQKKEPEP-KDEVLQQ----------KDKTLEHKEVVEPKD 1384
Query: 649 ----KKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKET 704
+K+E K E K++DK +K ++++ E +K++ EPK
Sbjct: 1385 TAIYQKDEALHVKNEAVKQQDKALEQKGRDLEQKDTALE-----QKDKALEPKD------ 1433
Query: 705 PPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEE 764
K+++++ K E+K+ EEK+ K ++ T L + K AL+PK E+
Sbjct: 1434 --KDLEEKDKALEQKDKIPEEKD---------KALEQKDTALEQ--KDKALEPKDKDLEQ 1480
Query: 765 SVKKDSVAAGK---PKEKGKI---KVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIG 818
KD V K P+EK K KV E KA E T A M +
Sbjct: 1481 ---KDRVLEQKEKIPEEKDKALDQKVRSVEHKAPE----------DTVAEMKDRDLEQTD 1527
Query: 819 PAKE----LEAERSLMSSPED--LTKDFEELKAEEVDVTKDIK--------PQLELIEDE 864
A E + ++ +S +D L + + L ++ + ++I+ + E + E
Sbjct: 1528 KAPEQKHQAQEQKDKVSEKKDQALEQKYWALGQKDEALEQNIQALEENHQTQEQESLVQE 1587
Query: 865 EKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEE---LEPVEK--QG 919
+K ++ + +E +K E K E + + T+ G E +E E EK +G
Sbjct: 1588 DKTRKPKMLE----EKSPEKVKAMEEKLEALLEKTKALGLEESLVQEGRAREQEEKYWRG 1643
Query: 920 VDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEED-----GEEHVCVS--------A 966
D ++++++ EE + G+ +E A E PE+D G E V + +
Sbjct: 1644 QDVVQEWQETSPTREEPA--GEQKELAPAWEDTSPEQDNRYWRGREDVALEQDTYWRELS 1701
Query: 967 SKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKA 1026
+ E A + E+RES D +D E + A +S +D +D
Sbjct: 1702 CERKVWFPHELDGQGARPHYTEERESTFL--DEGPDDEQEVPLREHATRSPWASDFKDFQ 1759
Query: 1027 EDAREEEYEPEKMEAEDYV-MAVVDKAAEAGGAEEQYGFLTTPTKQLGAQ---SPGREPA 1082
E + ++ E E+ AE V + ++ E +P + +G + +PG+E
Sbjct: 1760 ESSPQKGLEVERWLAESPVGLPPEEEDKLTRSPFEIISPPASPPEMVGQRVPSAPGQE-- 1817
Query: 1083 SSIHDETLPGGSESEATASD---------EENREDQPEEFTATSGYTQSTIEISSEPTPM 1133
S I D L ++E T ++R P + G PTP
Sbjct: 1818 SPIPDPKLMPHMKNEPTTPSWLADIPPWVPKDRPLPPAPLSPAPG----------PPTPA 1867
Query: 1134 DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYS---QEYSKPADVTPLNGFSEGS 1190
E TP + + QE + E YS ++Y K G +E
Sbjct: 1868 PESHTPAPFSWGTAEYDSVVAAVQE--GAAELEGGPYSPLGKDYRKAEGEREEEGRAEAP 1925
Query: 1191 KTDATDGKDYNASAS-TISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSE 1249
+ K AS S + P E ++ + D ++ DI + +
Sbjct: 1926 DKSSHSSKVPEASKSHATTEPEQTEPEQREPTPYPDE-----RSFQYADIYEQMMLTGLG 1980
Query: 1250 KVSPSKSPSLSPS---PPSPLEKTPLGERSVNFSLTPNEIKVSAEAEV-APVSPEVTQEV 1305
P++ P L + PP K R+ SAE E+ +P+SP
Sbjct: 1981 PACPTREPPLGAAGDWPPCLSTKEAAAGRN-----------TSAEKELSSPISP------ 2023
Query: 1306 VEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQ---SPTDEKSSHLP-----TEVIEKPP 1357
K+L+ +P+ S AG T + P+ E S P ++ K P
Sbjct: 2024 ----------KSLQSDTPTFSYAALAGPTVPPRPEPGPSMEPSLTPPAVPPRAPILSKGP 2073
Query: 1358 AVPVSFEFSDAKDENERASVSP---------------------MDEPVPDSESPIEKVLS 1396
+ P++ +R S SP ++P +++SP
Sbjct: 2074 SPPLNGNILSCSP--DRRSPSPKESGRSHWDDSTSDSELEKGAREQPEKEAQSPSPPHPI 2131
Query: 1397 PLRSPPLIGSESAY-----ESFL-----SADDKASGRGAESPFEEKSGKQGSPDQVSPVS 1446
P+ SP L A+ +S L S D AS G S Q +P Q+ +
Sbjct: 2132 PMGSPTLWPETEAHVSPPLDSHLGPARPSLDFPASAFGF-------SSLQPAPPQLPSPA 2184
Query: 1447 EMTSTSLYQDKQEG-KSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQI 1505
E S G ++ AP G +T E + A +LD SP+
Sbjct: 2185 EPRSAPCGSLAFSGDRALALAP-----GPPTRTRHDEYLEVTKAPSLDSSLPQLPSPSSP 2239
Query: 1506 DVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGV-------------ASV 1552
+ ++SEG+ S ++ TPV VAE +E A+
Sbjct: 2240 GAPLLSNLPRPASPALSEGS-SSEATTPVISSVAERFSPSLEAAEQESGELDPGMEPAAH 2298
Query: 1553 STASVATSSFPEPTTDDV----SPSLHAEVGS---PHSTEVDDSLSVSVVQTPTTFQETE 1605
S + S P + D+ +PSL ++G P E S + + P+ FQ
Sbjct: 2299 SLWDLTPLSPAPPASLDLALAPAPSLPGDMGDGILPCHLE----CSEAATEKPSPFQ--- 2351
Query: 1606 MSPSKEEC----PRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMD 1661
PS E+C P S +PP +P A++ E+ + E E+S D
Sbjct: 2352 -VPS-EDCAANGPTETSPNPPGPAPAKAENEEAAACPAWERGAW-----PEGAERSSRPD 2404
Query: 1662 FSRQSPDHPTVGAGVLHITENGP-----TEVDYSPSDMQDSSLSHK--------IPPMEE 1708
+ SP+ P AG GP EV+ P H+ PP+
Sbjct: 2405 -TLLSPEQPVCPAG----GSGGPPSSASPEVEAGPQGCATEPRPHRGELSPSFLNPPL-- 2457
Query: 1709 PSYTQDNDLS 1718
P D DLS
Sbjct: 2458 PPSIDDRDLS 2467
Score = 34.3 bits (77), Expect = 1.6
Identities = 34/137 (24%), Positives = 48/137 (35%), Gaps = 14/137 (10%)
Query: 2219 MVDPEALAIEQNLGKALKK-DLKEKTKTKKPGTKTKSSSPVKKSDG---KSKPLAASPKP 2274
+V+ A L K L K + K K ++KP K VK K++
Sbjct: 340 VVEEGAKEARSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKRKLIKDK 399
Query: 2275 AGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKT 2334
G K +K+S++ K KE E+K R E K E + A K K
Sbjct: 400 VGKKHLKEKISKLEEKKDKEK----------KEIKKERKELKKDEGRKEEKKDAKKEEKR 449
Query: 2335 ATAGPGTTKTTKSSAVP 2351
P K +K P
Sbjct: 450 KDTKPELKKISKPDLKP 466
>gi|50428935 BPY2 interacting protein 1 [Homo sapiens]
Length = 1059
Score = 446 bits (1147), Expect = e-124
Identities = 270/639 (42%), Positives = 374/639 (58%), Gaps = 81/639 (12%)
Query: 16 SIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRAIGNIELGIRSWDTNLIECNL 75
++A A+ +PS LLVV E + L + +E GIRSWD + CNL
Sbjct: 3 AVAGSGAAAAPSS---------LLLVVGSEFGSPGLLTYVLEELERGIRSWDVDPGVCNL 53
Query: 76 DQELKLFVSRHSARFSPEVPGQKILHHRSDVLETVVLINPSDEAVSTEVRLMITDAARHK 135
D++LK+FVSRHSA FS V GQ+ LHHR D LET+VL+NPSD+++ E+R ++ D A HK
Sbjct: 54 DEQLKVFVSRHSATFSSIVKGQRSLHHRGDNLETLVLLNPSDKSLYDELRNLLLDPASHK 113
Query: 136 LLVLTGQCFENTGELILQSGSFSFQNFIEIFTDQEIGELLSTTHP-ANKASLTLFCPEEG 194
LLVL G C E TGEL+LQ+G FS +F+++ D+EI ++L+TT P LT+ CP G
Sbjct: 114 LLVLAGPCLEETGELLLQTGGFSPHHFLQVLKDREIRDILATTPPPVQPPILTITCPTFG 173
Query: 195 DWKNSNLDRHNLQDFINI--KLNSASILPEMEGLSEFTEYLSESVEVPSPFDILEPPTSG 252
DW LQ + + +LN + LP EGL EF EY++ES+E PSPF++LEPPTSG
Sbjct: 174 DWAQLAPAVPGLQGALRLQLRLNPPAQLPNSEGLCEFLEYVAESLEPPSPFELLEPPTSG 233
Query: 253 GFLKLSKPCCYIFPGGRGDSALFAVNGFNMLINGGSERKSCFWKLIRHLDRVDSILLTHI 312
GFL+L +PCCYIFPGG GD+A FAVNGF +L+NGGS KS FWKL+RHLDRVD++L+TH
Sbjct: 234 GFLRLGRPCCYIFPGGLGDAAFFAVNGFTVLVNGGSNPKSSFWKLVRHLDRVDAVLVTHP 293
Query: 313 GDDNLPGINSMLQRKIAELEEEQSQGSTTNSDWMKNLISPDLGVVFLNVPENLKNPEPNI 372
G D+LPG+NS+L+RK+AE E + G + + D ++ LISP+LGVVF N E
Sbjct: 294 GADSLPGLNSLLRRKLAERSEVAAGGGSWD-DRLRRLISPNLGVVFFNACEAAS------ 346
Query: 373 KMKRSIEEACFTLQYLNKLSMKPEPLFRSVGNTIDPVILFQKMGVGKLEMYVLNPVKSSK 432
++ R +EA L L +L + P PL R P +LF+KMGVG+L+MYVL+P +
Sbjct: 347 RLARGEDEAELALSLLAQLGITPLPLSRG-PVPAKPTVLFEKMGVGRLDMYVLHPPSAGA 405
Query: 433 EMQYFMQQWTGTNKDKAEFILPNGQEVDLPISYLTSVSSLIVWHPANPAEKIIRVLFPGN 492
E L SV +L+VWHPA P EK++RVLFPG
Sbjct: 406 ERT------------------------------LASVCALLVWHPAGPGEKVVRVLFPGC 435
Query: 493 STQYNILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPL 552
+ +L+GL +L+HL FL++P+ T +DL G RA+S+ES+
Sbjct: 436 TPPACLLDGLVRLQHLRFLREPVVTPQDLEG------------PGRAESKESV------- 476
Query: 553 PSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEE 612
R SK E T ++ P V KE + + P KTE K + T +E+ K++
Sbjct: 477 ---GSRDSSKREGLLATHPRPGQERPGVARKEP--ARAEAPRKTE-KEAKTPREL--KKD 528
Query: 613 PSPVKAEVAEKQATDVKPKAAKEKTVKK-ETKVKPEDKK 650
P P V+ Q +V+ A+ +KK + P+ +K
Sbjct: 529 PKP---SVSRTQPREVRRAASSVPNLKKTNAQAAPKPRK 564
Score = 207 bits (527), Expect = 1e-52
Identities = 160/477 (33%), Positives = 233/477 (48%), Gaps = 85/477 (17%)
Query: 2009 ETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYET---AEKITRTPQASTYSYE----- 2060
E +E+++ P G + ++ T TP +T + T ++ + S+E
Sbjct: 649 EGSERLSLSPLRGGEAGPDASPTVTTPTVTTPSLPAEVGSPHSTEVDESLSVSFEQVLPP 708
Query: 2061 ---TSDLCYTAEKKSPSEARQ----DVDLCLVSSCEYKHPKT-ELSPSFINPNPLEWFAS 2112
TS+ + + P R DVDLCLVS CE++H K ++P+ +P +S
Sbjct: 709 SAPTSEAGLSLPLRGPRARRSASPHDVDLCLVSPCEFEHRKAVPMAPAPASPG-----SS 763
Query: 2113 EEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSI 2172
+ + S++ + G +ETPPTSVSES P+ +DSD P
Sbjct: 764 NDSSARSQE--------------RAGGLGAEETPPTSVSESLPTLSDSDPVP-------- 801
Query: 2173 TADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLG 2232
A DS++++E + DP P P++ P P + MVDPE L +
Sbjct: 802 LAPGAADSDEDTEGFGVPRH------DPLPDPLKVPPPLPDPSSICMVDPEMLPPKT--- 852
Query: 2233 KALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKK 2292
+ + ++T+KP + S + K+ P+AA+ K GL D+ SR S
Sbjct: 853 ---ARQTENVSRTRKPLARPNSRAAAPKAT----PVAAA-KTKGLA-GGDRASRPLS--- 900
Query: 2293 KESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKS--SAV 2350
AR E +K + A + S + KTAT GP + +++ SA
Sbjct: 901 ------------------ARSEPSEKGGR-APLSRKSSTPKTATRGPSGSASSRPGVSAT 941
Query: 2351 PPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGNDPAAEEPSRAVLDALLEGKA 2410
PP PVYLDL Y+P+ S++ VD EFF+RVR+ YV+SG D EE RAVLDALL K
Sbjct: 942 PPKSPVYLDLAYLPSGSSAHLVDEEFFQRVRALCYVISGQDQRKEEGMRAVLDALLASKQ 1001
Query: 2411 QWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLASSSTVVMQDESFPACKIE 2467
W ++QVTLIPT DS M WY ETH + Q L I VL S+S V MQD++FPACK+E
Sbjct: 1002 HWDRDLQVTLIPTFDSVAMHTWYAETHARHQALGITVLGSNSMVSMQDDAFPACKVE 1058
Score = 50.8 bits (120), Expect = 2e-05
Identities = 70/267 (26%), Positives = 100/267 (37%), Gaps = 36/267 (13%)
Query: 1563 PEPTTDDVS-PSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISP 1621
P TT V+ PSL AEVGSPHSTEVD+SLSVS Q + PS +S+
Sbjct: 670 PTVTTPTVTTPSLPAEVGSPHSTEVDESLSVSFEQV--------LPPSAPTSEAGLSL-- 719
Query: 1622 PDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESP--EQSLAMDFSRQSPDHPTVGAGVLHI 1679
P P+ +S +P S E + P + S S AG L
Sbjct: 720 PLRGPRARRSASPHDVDLCLVSPCEFEHRKAVPMAPAPASPGSSNDSSARSQERAGGLGA 779
Query: 1680 TENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPS 1739
E PT V S + DS P P ++ +E V + + P P
Sbjct: 780 EETPPTSVSESLPTLSDSD-----PVPLAPGAADSDEDTEGFGVPRHDPLPD------PL 828
Query: 1740 QIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPT 1799
++ PL + + + P + + +E V P S R ++P +P
Sbjct: 829 KVPPPLPDPSSICMVDPEMLPPKTARQTENVSRTRKPLARPNS-------RAAAPKATP- 880
Query: 1800 FSDSTSAVKEKTATCHSSSSPPIDAAS 1826
+A K K +S P+ A S
Sbjct: 881 ----VAAAKTKGLAGGDRASRPLSARS 903
Score = 37.4 bits (85), Expect = 0.18
Identities = 40/154 (25%), Positives = 64/154 (41%), Gaps = 26/154 (16%)
Query: 616 VKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKE---VAKKEDKTPIKKE 672
++ V Q + +A +++V K E +P +E VA+KE
Sbjct: 454 LREPVVTPQDLEGPGRAESKESVGSRDSSKREGLLATHPRPGQERPGVARKE-------- 505
Query: 673 EKPKKEEVKKEVKKEIK--KEEKKEPKKEVKKETPPKEVKK------EVKKEEKKEVKKE 724
P + E ++ +KE K +E KK+PK V + T P+EV++ +KK + K
Sbjct: 506 --PARAEAPRKTEKEAKTPRELKKDPKPSVSR-TQPREVRRAASSVPNLKKTNAQAAPKP 562
Query: 725 EKEPKKEIKKLPKDAKKSSTPLS----EAKKPAA 754
K P P A +P S EA P+A
Sbjct: 563 RKAPSTSHSGFPPVANGPRSPPSLRCGEASPPSA 596
Score = 32.7 bits (73), Expect = 4.5
Identities = 37/172 (21%), Positives = 71/172 (41%), Gaps = 11/172 (6%)
Query: 671 KEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKK 730
KE ++ K+E +E +KE E ++ +KE K ++ +K+PK
Sbjct: 473 KESVGSRDSSKREGLLATHPRPGQERPGVARKEPARAEAPRKTEKEAKTP-RELKKDPKP 531
Query: 731 EIKKL-PKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSV--AAGKPKEKGKIKVIKK 787
+ + P++ +++++ + KK A P+K S A P+ ++
Sbjct: 532 SVSRTQPREVRRAASSVPNLKKTNAQAAPKPRKAPSTSHSGFPPVANGPRSPPSLRC--- 588
Query: 788 EGKAAEAVAAAVGTGATTAAVMAAAGIAAI--GPAKELEAERSLMSSPEDLT 837
G+A+ +AA G+ A+ + + I G K LE + S P T
Sbjct: 589 -GEASPP-SAACGSPASQLVATPSLELGPIPAGEEKALELPLAASSIPRPRT 638
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 131 bits (329), Expect = 9e-30
Identities = 161/545 (29%), Positives = 231/545 (42%), Gaps = 71/545 (13%)
Query: 540 DSRESLKPAAK-PLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTET 598
+++ +K AK P +KS KE + EV + P K E+K K P K E
Sbjct: 515 EAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAK--SPEKEEA 572
Query: 599 K-----PSVTEKEVPSKEE-PSPVKAEVAEKQATDVKPKAAK----EKTVKKETKVKPED 648
K S + + P+KEE SP +A+ EK + VK +A + VK+E K E
Sbjct: 573 KSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEV 632
Query: 649 KKEEKEK-PKKEVAKKEDKTPI-KKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPP 706
K EK K P KE AK +K +KEE E+ K VK E K EK K VK E
Sbjct: 633 KSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK--AKSPVKAEAKS 690
Query: 707 KEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESV 766
E K KEE K +K K P KE K P+ AK S EAK P K K P KEE+
Sbjct: 691 PEKAKSPVKEEAKSPEK-AKSPVKEEAKSPEKAK--SPVKEEAKTPE--KAKSPVKEEA- 744
Query: 767 KKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAE 826
S K EK K +K A T A A A P K
Sbjct: 745 --KSPEKAKSPEKAKTLDVK-------------SPEAKTPAKEEARSPADKFPEKAKSPV 789
Query: 827 RSLMSSPEDLTKDF-EELKAEEVDVTK--DIKPQLELIEDEEKLKETEPVEAYVIQKERE 883
+ + SPE E+ KA E ++ K ++K ++ E +++K EP K+ E
Sbjct: 790 KEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEP------PKKAE 843
Query: 884 VTKGPAESPDEGITTTEGEGECEQTPEELEP---VEKQGVDDIEKFEDEGAGFEESSETG 940
K PA T + + + E+ P++ P VE++ +EK ++ + E E
Sbjct: 844 EEKAPATPK----TEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKE--SKVEAKKEEA 897
Query: 941 DYEEKAETEEAEEP-----EEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVAS 995
+ ++K T E E P +ED + +K P + AKA+ + EK+E+
Sbjct: 898 EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEP----DDAKAKEPSKPAEKKEAAPE 953
Query: 996 GDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDY------VMAVV 1049
D EE + EK + E +E D+ E ++ + + EK + D A
Sbjct: 954 KKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATE 1013
Query: 1050 DKAAE 1054
DKAA+
Sbjct: 1014 DKAAK 1018
Score = 127 bits (320), Expect = 1e-28
Identities = 130/396 (32%), Positives = 180/396 (45%), Gaps = 41/396 (10%)
Query: 503 EKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESK 562
E+ K + K P + + +PV + K ++A S + A P +KS KE +
Sbjct: 644 EEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAE-AKSPEKAKSPVKE-E 701
Query: 563 EETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAE 622
++PE K P K E+K K P+K E K K +E SP KA+ E
Sbjct: 702 AKSPEKAK-----SPVKEEAKSPEKAK--SPVKEEAKTPEKAKSPVKEEAKSPEKAKSPE 754
Query: 623 KQATDVKPKAAKEKTVKKETKVKPEDKKEEKEK-PKKEVAKKED--KTPIKKEEK----- 674
K T + K+ + KT KE P DK EK K P KE K + K+P+K++ K
Sbjct: 755 KAKT-LDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKE 813
Query: 675 -PKKEEVKKEVKKEIKKEE--KKEPKKEVKKETPPKEVKKEVKKEEKKE--VKKEEKEPK 729
PKKEEVK VK+E K +E KEP K+ ++E P K E KK+ KKE KKE +PK
Sbjct: 814 IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPK 873
Query: 730 KEIKKLPKDAKKSSTPLSEAKKPAALKPKV--PKKEESVKKDSVAAGKPKEKGKIKVIKK 787
E KK P K + + K+ A K KV P+KE K + KPKE K +V KK
Sbjct: 874 VEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKE--KTEVAKK 931
Query: 788 EGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEE 847
E A+A + AA P K+ + + PE+ K E KA+E
Sbjct: 932 EPDDAKAKEPSKPAEKKEAA-----------PEKK-DTKEEKAKKPEEKPK--TEAKAKE 977
Query: 848 VDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKERE 883
D T +P E EK T+ ++ +K E
Sbjct: 978 DDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATE 1013
Score = 121 bits (303), Expect = 1e-26
Identities = 147/560 (26%), Positives = 229/560 (40%), Gaps = 90/560 (16%)
Query: 512 KQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAK-----PLPSKSVRKESKEETP 566
K P+ + + +P ++ K S E K AK P +KS KE +
Sbjct: 517 KSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPA 576
Query: 567 EVTKVNHVEKPPKVESKEKVMVKKDK----PIKTETKPSVTEKEVPSKEEPSPVKAEVAE 622
EV + P K E+K K + P+K E K K +E SP + + E
Sbjct: 577 EVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPE 636
Query: 623 KQATDVKPKAA---KEKTVKKE---------TKVKPEDKKEEKEK-PKKEVAKKEDK--T 667
K + K +A K K+ +KE + VK E K EK K P K AK +K +
Sbjct: 637 KAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKS 696
Query: 668 PIKKEEKPKKEEVKKEVKKEIKKEEK-KEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEK 726
P+K+E K E+ K VK+E K EK K P KE K P++ K VK+E K K +
Sbjct: 697 PVKEEAK-SPEKAKSPVKEEAKSPEKAKSPVKEEAKT--PEKAKSPVKEEAKSPEKAKSP 753
Query: 727 EPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIK 786
E K + +AK + EA+ PA K P+K +S K+ V K EK K +K
Sbjct: 754 EKAKTLDVKSPEAKTPAK--EEARSPA---DKFPEKAKSPVKEEV---KSPEKAK-SPLK 804
Query: 787 KEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAE 846
++ KA P KE+ + + S + EE K +
Sbjct: 805 EDAKA---------------------------PEKEIPKKEEVKSPVK------EEEKPQ 831
Query: 847 EVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECE 906
EV V + K +EEK T E K+ E K A P + E E
Sbjct: 832 EVKVKEPPKK-----AEEEKAPATPKTEEKKDSKKEEAPKKEAPKPK---VEEKKEPAVE 883
Query: 907 QTPEELEPVEKQGVDDIEKF---EDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVC 963
+ E +K+ +D +K E E E E +EK E + E + +E
Sbjct: 884 KPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSK 943
Query: 964 VSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEE 1023
+ K + E +++ + +A +K E + +A+ED D+ + K E S+ +A++
Sbjct: 944 PAEKKEAAPEKKDTKEEKA-----KKPEEKPKTEAKAKED-DKTLSK---EPSKPKAEKA 994
Query: 1024 DKAEDAREEEYEPEKMEAED 1043
+K+ +++ +P + ED
Sbjct: 995 EKSSSTDQKDSKPPEKATED 1014
Score = 111 bits (278), Expect = 8e-24
Identities = 117/431 (27%), Positives = 184/431 (42%), Gaps = 45/431 (10%)
Query: 512 KQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKV 571
K P+ + + +PV ++ K S E K K +KS K E E
Sbjct: 605 KSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKE-EAKSPEKAKSPEKEEAKSP 663
Query: 572 NHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEP-------SPVKAEVA--E 622
+ P K E+K K P+K E K S + + P KEE SPVK E E
Sbjct: 664 EKAKSPVKAEAKSPEKAKS--PVKAEAK-SPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE 720
Query: 623 KQATDVKPKAA---KEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEE 679
K + VK +A K K+ KE PE K ++ +V E KTP K+E + ++
Sbjct: 721 KAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADK 780
Query: 680 VKKEVKKEIKKEEKKEPKKEVKKETPPKE----VKKEVKKEE--KKEVKKEEKEPKKEIK 733
++ K +K EE K P+K ++P KE +KE+ K+E K VK+EEK + ++K
Sbjct: 781 FPEKAKSPVK-EEVKSPEKA---KSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVK 836
Query: 734 KLPKDAKKSSTPLS-------EAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIK 786
+ PK A++ P + ++KK A K + PK + KK+ A KPKE K++ K
Sbjct: 837 EPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEP-AVEKPKE-SKVEAKK 894
Query: 787 KEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAE 846
+E + + V T A A + AK E P+D AE
Sbjct: 895 EEAEDKKKV--------PTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAE 946
Query: 847 EVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECE 906
+ + + K E E +K +E EA + ++ ++K P++ E + + +
Sbjct: 947 KKEAAPEKKDTKE--EKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKD 1004
Query: 907 QTPEELEPVEK 917
P E +K
Sbjct: 1005 SKPPEKATEDK 1015
Score = 103 bits (256), Expect = 3e-21
Identities = 81/249 (32%), Positives = 122/249 (48%), Gaps = 32/249 (12%)
Query: 527 TPVVKQTKLKQRADS--RESLKPAAKPLPSKSVRKE--SKEETPEVTKVNHVEKPPKVES 582
+PV ++ K ++A S +E K K +P K K +EE P+ KV ++PPK
Sbjct: 787 SPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKV---KEPPKKAE 843
Query: 583 KEKVMV-----------KKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPK 631
+EK K++ P K KP V EK+ P+ E+P K E +++A D K
Sbjct: 844 EEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKK-- 901
Query: 632 AAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKE-DKTPIKKEEKPKKEEVKKEVKKEIKK 690
K T +KE K E K++ K K K EVAKKE D K+ KP +++ KK+ K+
Sbjct: 902 --KVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKE 959
Query: 691 EEKKEPKKEVKKETPPKEVKKEVKKEEKK-EVKKEEKEPKKEIKKLPKDAKKSSTPLSEA 749
E+ K+P+++ K E KE K + KE K + +K EK + +K S P +A
Sbjct: 960 EKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTD--------QKDSKPPEKA 1011
Query: 750 KKPAALKPK 758
+ A K K
Sbjct: 1012 TEDKAAKGK 1020
Score = 89.7 bits (221), Expect = 3e-17
Identities = 190/905 (20%), Positives = 353/905 (39%), Gaps = 100/905 (11%)
Query: 649 KKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKE 708
++EE E + +A+ + + + KK + +E +++ ++E + + +
Sbjct: 191 QREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGA 250
Query: 709 VKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKK 768
+ +++ E + +K + +EI+ + ST SE + ++ + E+ K
Sbjct: 251 AQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEW----FRVRLDRLSEAAKV 306
Query: 769 DSVAAGKPKE-----KGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPA-KE 822
++ A +E + +++ E +A ++ ++ + A IA+ A ++
Sbjct: 307 NTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQ 366
Query: 823 LEAE-RSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKE 881
L+AE R+ +++++L ++ + +I +L+E EE P+ +
Sbjct: 367 LDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSL---- 422
Query: 882 REVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGD 941
P P +T + + E+ + +E EK+ V E+ E+ + + E +
Sbjct: 423 ------PEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEET----QVTEEVTE 472
Query: 942 YEEKAETEEAEEPEEDGEEHVCVSA---SKHSPTEDEESAKAEADAYIREKRESVASGDD 998
EEK EE + EE GEE +K P E+ S + EA + ++E+ +S A
Sbjct: 473 EEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKS 532
Query: 999 RAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGA 1058
+E+ E E+++ A EE K+ E PEK EA+ AE
Sbjct: 533 PEKEEAKSPAEVKSPEKAKSPAKEEAKSP---PEAKSPEKEEAK--------SPAEVKSP 581
Query: 1059 EEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSES---EATASDEENREDQPEEFTA 1115
E+ A+SP +E A S + P ++S E S E + EE A
Sbjct: 582 EK-------------AKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEE--A 626
Query: 1116 TSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYS 1175
S + E + PT +E +P S E EE +SP K +S + ++ S
Sbjct: 627 KSPAEVKSPEKAKSPT-KEEAKSPEKAKSPE--KEEAKSPE-------KAKSPVKAEAKS 676
Query: 1176 KPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKAST 1235
+P+ ++ + + K+ S P ++E+ S + E K
Sbjct: 677 PEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP--VKEEAKSPEKAKSPVKEEAKTPE 734
Query: 1236 TLDIKDSISAVSSEKV-SPSKSPSLSPSPPSPLEKTPLGERSVN-FSLTPNEIKVSAEAE 1293
A S EK SP K+ +L SP KTP E + + P + K + E
Sbjct: 735 KAKSPVKEEAKSPEKAKSPEKAKTLDVK--SPEAKTPAKEEARSPADKFPEKAKSPVKEE 792
Query: 1294 VAPVSPEVTQEVVEEHCASPE---DKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPT 1350
V SPE + ++E +PE K EV SP + + P + K P
Sbjct: 793 VK--SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKE----------EEKPQEVKVKEPPK 840
Query: 1351 EV-IEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESA 1409
+ EK PA P + E D+K E +P + E +EK P S E A
Sbjct: 841 KAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEK---PKESKVEAKKEEA 897
Query: 1410 YESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVS--EMTSTSLYQDKQEGKSTDFAP 1467
+ K E+P + + + P + + V+ E + + + + AP
Sbjct: 898 EDK-----KKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAP 952
Query: 1468 IKEDFGQEKKTDDVEAMSSQPALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTV 1526
K+D +EK E ++ D++ L + S + + ++ S + E
Sbjct: 953 EKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKAT 1012
Query: 1527 SDKSA 1531
DK+A
Sbjct: 1013 EDKAA 1017
Score = 66.6 bits (161), Expect = 3e-10
Identities = 59/207 (28%), Positives = 90/207 (43%), Gaps = 27/207 (13%)
Query: 503 EKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESK 562
EK + + + P +++ P K+ K+ A +E+ KP + +KE
Sbjct: 828 EKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEE------KKEPA 881
Query: 563 EETPEVTKVNHVEKPPKVESKEKVMV-KKDKPIKTETKPSVTEKEVP--SKEEPSPVKAE 619
E P+ +KV K + E K+KV +K+ P K E K KE +K+EP KA+
Sbjct: 882 VEKPKESKVE--AKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAK 939
Query: 620 -----VAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEK 674
+K+A K +EK K E K K E K AK++DKT K+ K
Sbjct: 940 EPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAK-----------AKEDDKTLSKEPSK 988
Query: 675 PKKEEVKKEVKKEIKKEEKKEPKKEVK 701
PK E+ +K + K + E E K
Sbjct: 989 PKAEKAEKSSSTDQKDSKPPEKATEDK 1015
Score = 60.1 bits (144), Expect = 3e-08
Identities = 129/691 (18%), Positives = 242/691 (35%), Gaps = 140/691 (20%)
Query: 1629 AKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVD 1688
++ T + + ++E++ ++ E +E +++ + + G T++ P E
Sbjct: 450 SEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEA 509
Query: 1689 YSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEA-----SPSTSSAHTPSQIAS 1743
SP S + + + P+ + + E S ++V++ SP+ A +P + S
Sbjct: 510 ASPEKEAKSPVKEEA---KSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKS 566
Query: 1744 PLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPTFSDS 1803
P +E+ S E SP+ SP SP + + +
Sbjct: 567 PEKEEAKSPA----------------------EVKSPEKAKSPAKEEAKSPAEAKSPEKA 604
Query: 1804 TSAVKEKTATCHSSSSPPIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGK 1863
S VKE+ + + SP + A S ++ K
Sbjct: 605 KSPVKEEAKSPAEAKSPVKEEAK-------------------------SPAEVKSPEKAK 639
Query: 1864 TPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYSY 1923
+P + K E +SP++E+ K+ ++ K KSP
Sbjct: 640 SP---TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA------KSPEKAKSP------- 683
Query: 1924 ETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSYDISEKTTSPPEVSGYSYEKTERSRRL 1983
+ K+PE +++ ++PE+ + E+ SP + E+ +
Sbjct: 684 --VKAEAKSPEKAKSP---VKEEAKSPEKA--KSPVKEEAKSPEKAKSPVKEEAKT---- 732
Query: 1984 LDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYE 2043
P + ++ PE + T ++P+ T E
Sbjct: 733 --------------------PEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKE 772
Query: 2044 TAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFIN 2103
A R+P S + E KSP +A+ + + K P+ E+
Sbjct: 773 EA----RSPADKFPEKAKSPV--KEEVKSPEKAKSPLKE------DAKAPEKEI------ 814
Query: 2104 PNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPT-----SVSESAPSQ- 2157
P E + P +E EKP PP K + + TP T S E AP +
Sbjct: 815 PKKEE---VKSPVKEEEKPQEVKVKEPPK---KAEEEKAPATPKTEEKKDSKKEEAPKKE 868
Query: 2158 -----TDSDVPPETEECPSITADANIDSEDESETIPT-DKTVTYK-HMDPPPAPVQDRSP 2210
+ P E+ +A + ++ + +PT +K K + P +
Sbjct: 869 APKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEV 928
Query: 2211 SPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAA 2270
+ + PD + + E+ KKD KE+ K KKP K K+ + K+ D +
Sbjct: 929 AKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE-KAKKPEEKPKTEAKAKEDDKTLSKEPS 987
Query: 2271 SPKPAGLKESSDKVSRVASPKKKESVEKAAK 2301
PK ++SS + + P +K + +KAAK
Sbjct: 988 KPKAEKAEKSSSTDQKDSKPPEKATEDKAAK 1018
Score = 58.2 bits (139), Expect = 1e-07
Identities = 62/264 (23%), Positives = 100/264 (37%), Gaps = 26/264 (9%)
Query: 2094 KTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSES 2153
K+E + E +EE TEE EK + G G +++ +E + +E
Sbjct: 449 KSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEE 508
Query: 2154 APSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPR 2213
A S P EE S A+A ++E+++ K + +P ++ + SP
Sbjct: 509 AASPEKEAKSPVKEEAKS-PAEAKSPEKEEAKS-----PAEVKSPEKAKSPAKEEAKSP- 561
Query: 2214 HPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPK 2273
PEA + E+ K+ ++K K K P + S KS K+K
Sbjct: 562 --------PEAKSPEKEEAKS-PAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEA 612
Query: 2274 PAGLKESSDKVSRVASPKKKESVEKAAKPT----------TTPEVKAARGEEKDKETKNA 2323
+ + S SP + +S EKA PT +PE + A+ EK K A
Sbjct: 613 KSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKA 672
Query: 2324 ANASASKSAKTATAGPGTTKTTKS 2347
S K+ A + + KS
Sbjct: 673 EAKSPEKAKSPVKAEAKSPEKAKS 696
Score = 55.8 bits (133), Expect = 5e-07
Identities = 114/532 (21%), Positives = 196/532 (36%), Gaps = 94/532 (17%)
Query: 1907 EKIERTTKSPSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSYDIS---EKT 1963
EKI+ KS ++ E +T T E + + ++ EEGG + E+T
Sbjct: 442 EKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEET 501
Query: 1964 TSPPEVSGYSYEKT------ERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSF 2017
SPP S EK E ++ + S ++++ E+ S
Sbjct: 502 KSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSP 561
Query: 2018 PESEGYSYET--STKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSE 2075
PE++ E S ++P+ + A++ ++P A S E + E KSP+E
Sbjct: 562 PEAKSPEKEEAKSPAEVKSPEKAK---SPAKEEAKSP-AEAKSPEKAKSPVKEEAKSPAE 617
Query: 2076 ARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTE-----ESEKPLTQSGGAP 2130
A+ V S E K P+ SP+ E S E E +++ P+ +P
Sbjct: 618 AKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSP 677
Query: 2131 P------------PPGGKQQGRQCDETP-----PTSVSESAPSQTDSDVPPETEECPSIT 2173
P K ++ ++P P +P + S V E +
Sbjct: 678 EKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAK 737
Query: 2174 ADANIDSEDESETIPTDKTVTYKHMDPP---PAPVQDRSPSPRHPDV------------- 2217
+ +++ + +K T P PA + RSP+ + P+
Sbjct: 738 SPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPE 797
Query: 2218 ---SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKP 2274
S + +A A E+ + K K+++K K ++ + K P KK++ + P A+PK
Sbjct: 798 KAKSPLKEDAKAPEKEIPK--KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAP--ATPKT 853
Query: 2275 AGLKESS-DKVSRVASPK------KKESVEKAA--------------KPTTTPEVKA--- 2310
K+S ++ + +PK K+ +VEK K TPE +A
Sbjct: 854 EEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAK 913
Query: 2311 ------ARGEEK----DKETKNAANASASKSAKTATAGPGTTKTTKSSAVPP 2352
A+ +EK KE +A SK A+ A P T + A P
Sbjct: 914 VEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKP 965
Score = 55.5 bits (132), Expect = 7e-07
Identities = 91/396 (22%), Positives = 158/396 (39%), Gaps = 45/396 (11%)
Query: 1288 VSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHT---PYYQSPTDEK 1344
V + E V+ EVT+E EE A E+ E + G T P ++ + EK
Sbjct: 457 VEEQTEETQVTEEVTEE--EEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEK 514
Query: 1345 SSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPV-------PDSESPI-EKVLS 1396
+ P + K PA S E +AK E S P P+++SP E+ S
Sbjct: 515 EAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKS 574
Query: 1397 P--LRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMT-STSL 1453
P ++SP S + E+ A+ K+ + A+SP +E++ + + SPV E S +
Sbjct: 575 PAEVKSPEKAKSPAKEEAKSPAEAKSPEK-AKSPVKEEA--KSPAEAKSPVKEEAKSPAE 631
Query: 1454 YQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSF 1513
+ ++ KS P KE+ K + ++ + A + ++ K SP + +
Sbjct: 632 VKSPEKAKS----PTKEE---AKSPEKAKSPEKEEAKSPEKAK----SPVKAEAKSPEKA 680
Query: 1514 KEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEP--TTDDVS 1571
K K +E +K+ +PV E + + A S E T +
Sbjct: 681 KSPVK---AEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAK 737
Query: 1572 PSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKS 1631
+ E SP + + V++P +P+KEE SP D P+ AKS
Sbjct: 738 SPVKEEAKSPEKAKSPEKAKTLDVKSPEA-----KTPAKEEAR-----SPADKFPEKAKS 787
Query: 1632 RTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSP 1667
+ E++ ++ ++PE+ + +SP
Sbjct: 788 PVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP 823
Score = 54.3 bits (129), Expect = 1e-06
Identities = 69/286 (24%), Positives = 113/286 (39%), Gaps = 33/286 (11%)
Query: 2069 EKKSPSEAR--QDVDLCLVSSCEYKHPKTE--LSPSFINPNPLEWFASEE--PTEESEKP 2122
E KSP +A+ + V S E K P E SP+ P + EE E+++ P
Sbjct: 743 EAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSP 802
Query: 2123 LTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSED 2182
L + AP K++ E E P + PP+ E A + +
Sbjct: 803 LKEDAKAPEKEIPKKE-----EVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK 857
Query: 2183 ESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEK 2242
+S+ K K P P + + P+ P S V+ A K++ ++K
Sbjct: 858 DSK-----KEEAPKKEAPKPKVEEKKEPAVEKPKESKVE------------AKKEEAEDK 900
Query: 2243 TKTKKPGTKTKSSSPVK---KSDGKSKPLAASPKPAGLKESSDKVSRV-ASPKKKESVE- 2297
K P + + VK K K++ P A KE S + A+P+KK++ E
Sbjct: 901 KKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE 960
Query: 2298 KAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTK 2343
KA KP P+ +A E+ +K + A K+ K+++ +K
Sbjct: 961 KAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSK 1006
Score = 41.6 bits (96), Expect = 0.010
Identities = 79/383 (20%), Positives = 151/383 (39%), Gaps = 59/383 (15%)
Query: 1515 EDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVS-TASVATSSFPEPTTDDVSPS 1573
E+T+++ E T ++ +EG E+ E T S P + SP
Sbjct: 462 EETQVT-EEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSP- 519
Query: 1574 LHAEVGSP---HSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAK 1630
+ E SP S E +++ S + V++P E SP+KEE P P SP+ +
Sbjct: 520 VKEEAKSPAEAKSPEKEEAKSPAEVKSP----EKAKSPAKEEAKSP----PEAKSPEKEE 571
Query: 1631 SRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYS 1690
+++P + E++ + +SP ++ +SP+ S
Sbjct: 572 AKSPAEVKSPEKAKSPAKEEAKSPAEA-------KSPEKAK------------------S 606
Query: 1691 PSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTL 1750
P + S + P++E + + +E+ S + + SP+ A +P + SP +E+
Sbjct: 607 PVKEEAKSPAEAKSPVKEEAKSP----AEVKSPEKAK-SPTKEEAKSPEKAKSPEKEEAK 661
Query: 1751 SDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSP--LYSPTFSDSTSAVK 1808
S + A + ++ E SP+ SP+ SP SP ++ S K
Sbjct: 662 SPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEK 721
Query: 1809 EKTATCHSSSSP-----PIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGK 1863
K+ + +P P+ + P ++ T+ + + TP E+ +
Sbjct: 722 AKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLD---VKSPEAKTPAKEE---AR 775
Query: 1864 TPGD-FSYAYQKP-EETTRSPDE 1884
+P D F + P +E +SP++
Sbjct: 776 SPADKFPEKAKSPVKEEVKSPEK 798
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 122 bits (306), Expect = 4e-27
Identities = 310/1401 (22%), Positives = 555/1401 (39%), Gaps = 169/1401 (12%)
Query: 520 DLTGQVPTPVVKQTK-------LKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVN 572
+L G PTP + + + QRA S + L K P+ S K S P +
Sbjct: 1088 NLCGFNPTPHLTEIQEWLCLNCQTQRAISGQ-LGDIRKMPPAPSGPKASPMPVPTESSSQ 1146
Query: 573 HVEKPPKVESKEKVMVKKDKPIKTETKPSVTEK--EVPSKEE-PSPVKAEVAEKQATDVK 629
PP+V K++ K+++ +KTE + + EK E S E+ P V + ++++ K
Sbjct: 1147 KTAVPPQV----KLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEK 1202
Query: 630 PKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVK--KEVKKE 687
KA+ +E K PE+KK P++E + E+K P+ +E+KP E+ K E K
Sbjct: 1203 DKAS----ALQEKKPLPEEKKLI---PEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTS 1255
Query: 688 IKKEEKKEPKK---EVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSST 744
+E+K + K ++ +E V + +E K+ K E P + LPK+ K++
Sbjct: 1256 APEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTK 1315
Query: 745 PLSEAKKP-AALKPKV--PKKEESVKKDSVAAGKPKEKGKI-KVIKKEGKAAEAVAAAVG 800
+ E +P KP P KE++ K+D + ++ K + + G +++ +++++G
Sbjct: 1316 TIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLG 1375
Query: 801 TGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLEL 860
+ + G K+ ++ S SSP DL K E V ++ Q
Sbjct: 1376 E--IPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAK-------LESTVLSILEAQAST 1426
Query: 861 IEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPV-EKQG 919
+ DE+ K+T+P E + E+ + +S E + T E E +++ EE + +K
Sbjct: 1427 LADEKSEKKTQPHE---VSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDS 1483
Query: 920 VDDIEKFED--EGAGFEESSET-----GDYEEKAETEEAEEPEEDGEEHVCVSASKHSPT 972
DI +D E + F + T EE +E+E + P+ V S+S
Sbjct: 1484 QQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQ 1543
Query: 973 EDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREE 1032
ED + + E D +IR++ +++ +D + + DE I E S ++ + + +
Sbjct: 1544 EDSQGSGEEED-FIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGK 1602
Query: 1033 EYEPEKMEAEDYVMAVVDKAA---EAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDET 1089
+ +D+ A + E+ F +P + RE S +E
Sbjct: 1603 ITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKY------RETKSQESEEL 1656
Query: 1090 LPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNN 1149
+ G E ++++A S ++++ EP EM + D D +
Sbjct: 1657 VVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPEL--EMESLTDSPEDRSRG 1714
Query: 1150 EETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISP 1209
E S S + T S + +D +P + E + + + TI
Sbjct: 1715 EG--SSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIED 1772
Query: 1210 PSSMEEDKFSRSAL------RDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSP 1263
S EE + L R+ + K+S+ KD + + K+P PS
Sbjct: 1773 SSEEEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTP---PSN 1829
Query: 1264 PSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSP 1323
SP+E E + + E+ S+ +E +P S E E E SPE K +EV
Sbjct: 1830 LSPIEDASPTEE-LRQAAEMEELHRSSCSEYSP-SIESDPEGFE---ISPE-KIIEVQKV 1883
Query: 1324 SQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEP 1383
+ T + + SPTDE+S +++K + + +E + P
Sbjct: 1884 YKLPTAVSLY-----SPTDEQS------IMQKEGSQKALKSAEEMYEEMMHKTHKYKAFP 1932
Query: 1384 VPDSESPI-EKVLSPLRSPPLIGSESAYESFLSADDKASGRGA-------ESPFEEKSGK 1435
+ + EK PL LI + YES + S G+ E+ F ++ G+
Sbjct: 1933 AANERDEVFEK--EPLYGGMLI-EDYIYESLVEDTYNGSVDGSLLTRQEEENGFMQQKGR 1989
Query: 1436 QGS---PDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEK----KTDDVEAMSSQP 1488
+ +Q+ T L ++ E +S +ED ++ ++ + +
Sbjct: 1990 EQKIRLSEQIYEDPMQKITDLQKEFYELESLHSVVPQEDIVSSSFIIPESHEIVDLGTMV 2049
Query: 1489 ALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTY----- 1543
+ERKL D + + + +M ++ G S + P+ E + E T
Sbjct: 2050 TSTEEERKLLDAD------AAYEELMKRQQMQLTPG--SSPTQAPIGEDMTESTMDFDRM 2101
Query: 1544 -------SHMEGVASVSTASVATSSFPEP--TTDDVSPSLHAEVGSPHSTEVDDSLS-VS 1593
S + G + + S AT S P+ T + + E + ++ E+ + ++ S
Sbjct: 2102 PDASLTSSVLSGASLTDSTSSATLSIPDVKITQHFSTEEIEDEYVTDYTREIQEIIAHES 2161
Query: 1594 VVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS------EQSSMSI 1647
++ T + E+ S + P S++ S T S +P+ S E M
Sbjct: 2162 LILTYSEPSESATSVPPSDTP---SLTSSVSSVCTTDSSSPITTLDSITTVYTEPVDMIT 2218
Query: 1648 EFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITE--NGPTEVDY---SPSDMQDSSLSHK 1702
+F ++S E S + F D+P + L T +G D+ S SDM S +
Sbjct: 2219 KF-EDSEEISSSTYFPGSIIDYPEEISVSLDRTAPPDGRASADHIVISLSDMASSIIESV 2277
Query: 1703 IPPMEEP-SYTQDNDLSELISVSQVEASP-STSSAHTPSQIASPLQEDTLSDVAPPRDMS 1760
+P E P + T DL LIS E P + T + I + E RD
Sbjct: 2278 VPKPEGPVADTVSTDL--LIS----EKDPVKKAKKETGNGIILEVLEAY-------RDKK 2324
Query: 1761 LYASLTSEKVQSLEGEKL--SPKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSS 1818
L +E+ +S E + P S + L +E L + F+ + +EK A+ S
Sbjct: 2325 ---ELEAERTKSSLSETVFDHPPSSVIALPMKEQ--LSTTYFTSGETFGQEKPASQLPSG 2379
Query: 1819 SPPIDAASAEPYGFRASVLFD 1839
SP + + A+P F S D
Sbjct: 2380 SPSVSSLPAKPRPFFRSSSLD 2400
Score = 102 bits (254), Expect = 5e-21
Identities = 265/1334 (19%), Positives = 482/1334 (36%), Gaps = 191/1334 (14%)
Query: 526 PTPVVKQTKLKQRADSRESLKPAAKPLPSK------SVRKESKEETPEVTKVNHVEKPPK 579
P P Q KLK + S + P P + + K+ + PE K + K P
Sbjct: 652 PVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPT 711
Query: 580 VESKEKVMVKKDKPIKTETKPS-VTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTV 638
+ K+ + +KP+ E VPS+++ +PV A+ KQ VKP +
Sbjct: 712 LHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPV-ADDKPKQPKMVKPTTDLVSSS 770
Query: 639 KKETKVK-PEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPK 697
TK P K + + + K K D + P E+V K I +
Sbjct: 771 SATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPR--PASDS 828
Query: 698 KEVKKETPPKEVK--KEVKKEEKKEVKKE---EKEPKKEIKKLPKDAKKSSTPLSEAKKP 752
K + P E K K+V +KKE K+ + PK + K +PK + P A +
Sbjct: 829 KIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQT 888
Query: 753 AALKPKVPKKEESVKKDSVAAGK----PKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAV 808
+ PK +E ++ S+ G PK + GK A+ + +
Sbjct: 889 VPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLIST 948
Query: 809 MAAAG-IAAIGPAKELE-----AERSLMSSPEDLTKDFEELKAEEVDVTKDIK-PQLELI 861
G + GP ++ ++ P T A+ + V K+ K P E +
Sbjct: 949 AGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKL 1008
Query: 862 EDEEK----LKETE-PVEAYVIQKEREVTKGPAES--PDEGITTTEGEGECEQTPEEL-- 912
E + + +K TE + I+ + +T P ++ P + + + E C EL
Sbjct: 1009 EPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNI 1068
Query: 913 ---EPVEKQGVDDIEKFEDEGAGFEESSETGDYEE----KAETEEA-------------- 951
+P + + GF + + +E +T+ A
Sbjct: 1069 GSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPA 1128
Query: 952 ---------EEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEE 1002
P E + V + E+ K EA+ I EK + S
Sbjct: 1129 PSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLS------- 1181
Query: 1003 DMDEAIEKGEAEQSEEEAD-EEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQ 1061
M++ +Q +EE+ E+DKA +E++ PE+ + + E +EE+
Sbjct: 1182 -MEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKK--------LIPEEEKIRSEEK 1232
Query: 1062 YGFL-----TTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTAT 1116
L T K+L ++ P HD +S+ + EE E + T
Sbjct: 1233 KPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLL-----KSQVQIA-EEKLEGRVAPKTVQ 1286
Query: 1117 SGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSK 1176
G Q ++ P+ + D + +T E+ + P +K
Sbjct: 1287 EG-KQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCT-----------------AK 1328
Query: 1177 PADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTT 1236
P V P KT+ D K +S+ P + + +S + + E+ +
Sbjct: 1329 PDQVEP-----GKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSS-LGEIPSLIP 1382
Query: 1237 LDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP 1296
D KD + + + S SPS SPS + LE T L EA+ +
Sbjct: 1383 TDEKDILKGLKKDSFSQESSPS-SPSDLAKLESTVLS---------------ILEAQAST 1426
Query: 1297 VSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKP 1356
++ E +++ + H SPE + +QS++ + T + + + T +
Sbjct: 1427 LADEKSEKKTQPHEVSPEQPKDQ--EKTQSLSETLEITISEEEIKESQEERKDTFKKDSQ 1484
Query: 1357 PAVPVSFEFSDAKDENERA-SVSPMDEPVPDSESPIEKVLSPL---RSPPLIGSESAYES 1412
+P S D K+++E ++ EP E E SP+ + +GS S+ +
Sbjct: 1485 QDIPSS---KDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSS-DE 1540
Query: 1413 FLSADDKASGRGAE---------SPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQE---- 1459
+ D + SG + S E+ SG + + + E++S++ Q K+E
Sbjct: 1541 YKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGK 1600
Query: 1460 GKST----------DFAPIKEDFGQEKK--TDDVEAMSSQPALALDERKLGDVSPTQIDV 1507
GK T I ED G+ +D EA P L E K ++ V
Sbjct: 1601 GKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETK--SQESEELVV 1658
Query: 1508 SQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTT 1567
+ G + + ++ T++DK + E + T + + + S+ T S + +
Sbjct: 1659 TGGGGLRRFKTIELN-STIADKYSA---ESSQKKTSLYFDEEPELEMESL-TDSPEDRSR 1713
Query: 1568 DDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPK 1627
+ S SLHA +P ++ S + + ++ E ++ RP P
Sbjct: 1714 GEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDS 1773
Query: 1628 TAKSRTPVQDHRSEQSSMSIEFGQESPEQS----------LAMDFSRQSPDHPTVGAGVL 1677
+ + ++ ++ E Q+ + S L R+ P P + +
Sbjct: 1774 SEEEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPP--SNLS 1831
Query: 1678 HITENGPTEVDYSPSDMQD---SSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSS 1734
I + PTE ++M++ SS S P +E + ++I V +V P+ S
Sbjct: 1832 PIEDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVS 1891
Query: 1735 AHTPSQIASPLQED 1748
++P+ S +Q++
Sbjct: 1892 LYSPTDEQSIMQKE 1905
Score = 70.5 bits (171), Expect = 2e-11
Identities = 348/1859 (18%), Positives = 658/1859 (35%), Gaps = 316/1859 (16%)
Query: 503 EKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSR------------ESLKPAAK 550
EK+K QP T K + G TP KL + D+ ES+KP+
Sbjct: 245 EKIK-----SQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSL- 298
Query: 551 PLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSK 610
P PSK ++ P + H + P P K +PS K P
Sbjct: 299 PSPSKPPIQQPTPGKPPAQQPGHEKSQPG-------------PAKPPAQPSGLTK--PLA 343
Query: 611 EEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKED--KTP 668
++P VK V T KP A K + +K ++ K +A+ KTP
Sbjct: 344 QQPGTVKPPVQPPGTT--KPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTP 401
Query: 669 IKKE--EKPKKEEV---KKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKK 723
++ KP ++V K ++ + K P P K ++ +
Sbjct: 402 AQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSA 461
Query: 724 EEKEPKKEIKKLPKDAKKSSTPLSEAK----KPAALKP--------KVPKKEESVKKDSV 771
++ P K +LP AK AK +P + KP K P ++ K S
Sbjct: 462 QQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPS- 520
Query: 772 AAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMS 831
P++ G K ++ +A+ +A + A +A + ++ G K L+ S
Sbjct: 521 ----PQQPGSTKPPSQQPGSAKP-SAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPS 575
Query: 832 SPEDLTKDFEELKAEEVDVTK-------------------------DIKPQLELIEDEEK 866
+ + ++ + + T+ P L E +E
Sbjct: 576 AKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEW 635
Query: 867 LKETEPVEAYVIQKEREVTKGPAESPDEG-ITTTEGEGECEQTPEELEPVE----KQGVD 921
L ++ + V P +TTT + P++ P + KQ +
Sbjct: 636 LCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLS 695
Query: 922 DIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESA--- 978
+ + ++ + G KA+ + PE D P+E +++
Sbjct: 696 KAPEPKKPPPLVKQPTLHGSPSAKAK----QPPEADSLSKPAPPKEPSVPSEQDKAPVAD 751
Query: 979 -KAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPE 1037
K + ++ + V+S + D+ + + +AE+ + D A+ ++ E
Sbjct: 752 DKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGE 811
Query: 1038 KMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESE 1097
K+ D KA ++ + P+ ++S G++ + + P ++++
Sbjct: 812 KVSPFD------SKAIPRPASDSKIISHPGPS----SESKGQKQVDPVQKKEEPKKAQTK 861
Query: 1098 AT----ASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDE-MSTPRDVMSDETNNEET 1152
+ A P T+G T T + S +P S ++D ++ T
Sbjct: 862 MSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPT 921
Query: 1153 ESPSQEFVNITKYESSLYSQE------------YSKPADVTPLNGFSEGSKTDATDGKDY 1200
+ + +S++SQ +S+ P+ S+ + G
Sbjct: 922 TPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPK 981
Query: 1201 NASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLS 1260
+ + +P S+ K +++ + E KA +K + + + SKS +
Sbjct: 982 STGQAPPAPAKSIPVKKETKAPAAEKL--EPKAEQAPTVKRTETEKKPPPIKDSKSLTAE 1039
Query: 1261 PSP---PSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKT 1317
P P+ LEK+P E + T I S + E +V +P
Sbjct: 1040 PQKAVLPTKLEKSPKPESTCPLCKTELNIG-SKDPPNFNTCTECKNQVCNLCGFNPTPHL 1098
Query: 1318 LEV-------VSPSQSVTGSAGHTPYYQ-SPTDEKSSHLP--TEVIEKPPAVPVSFEFSD 1367
E+ ++++G G +P+ K+S +P TE + AVP +
Sbjct: 1099 TEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVK 1158
Query: 1368 AKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAES 1427
+++ + + +++ LS + PP++ ++ E DKAS +
Sbjct: 1159 KQEQEVKTEAEKV------ILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKK 1212
Query: 1428 PFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQ 1487
P E+ L ++++ +S + P+ E ++K T + + + +
Sbjct: 1213 PLPEEK------------------KLIPEEEKIRSEEKKPLLE---EKKPTPEDKKLLPE 1251
Query: 1488 PALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHME 1547
+ E + D+ +Q+ +++ EG V+ K+ V EG T ME
Sbjct: 1252 AKTSAPEEQKHDLLKSQVQIAE----------EKLEGRVAPKT---VQEGKQPQT--KME 1296
Query: 1548 GVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMS 1607
G+ S G+P S +D + +
Sbjct: 1297 GLPS---------------------------GTPQSLPKEDDKTTKTI------------ 1317
Query: 1608 PSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSP 1667
+E P+P + PD + K +T +D +S+ SS + P+ + + S
Sbjct: 1318 ---KEQPQPPCTAKPD-QVEPGKEKTEKEDDKSDTSS------SQQPKSPQGLSDTGYSS 1367
Query: 1668 DHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVE 1727
D + G + P+ + P+D +D + +++ S++Q++ S ++++E
Sbjct: 1368 DGISSSLGEI------PSLI---PTDEKDI-----LKGLKKDSFSQESSPSSPSDLAKLE 1413
Query: 1728 ASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPL 1787
ST + +Q AS L ++ P ++S EK QSL E L + IS
Sbjct: 1414 ---STVLSILEAQ-ASTLADEKSEKKTQPHEVSPEQPKDQEKTQSL-SETL--EITISEE 1466
Query: 1788 TPRESSPLYSPTF-SDSTSAVKEKTATCHSSSSPPID--AASAEPYGFRASVLFDTMQHH 1844
+ES TF DS + ++ H S +D EPY D+++
Sbjct: 1467 EIKESQEERKDTFKKDSQQDI--PSSKDHKEKSEFVDDITTRREPY--------DSVEES 1516
Query: 1845 LALNRDLSTPGLEKDSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGY 1904
+ S G + D K E++ S +EED+ + + + D G
Sbjct: 1517 SESENSPVPQRKRRTSVGSSSSD----EYKQEDSQGSGEEEDFIRKQIIEMSADEDASGS 1572
Query: 1905 YYEKIERT----TKSPSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSY--- 1957
++ R S ++S ET GK T G + + +T E+ G +
Sbjct: 1573 EDDEFIRNQLKEISSSTESQKKEETKGKGKITA--GKHRRLTRKSSTSIDEDAGRRHSWH 1630
Query: 1958 -DISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYD--DSEDGGHTLGDPSYSYETTEKI 2014
+ E PE+ Y K++ S L+ G + + T+ D YS E+++K
Sbjct: 1631 DEDDEAFDESPELK-YRETKSQESEELVVTGGGGLRRFKTIELNSTIAD-KYSAESSQKK 1688
Query: 2015 TSF-----PESEGYSYETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYT-- 2067
TS PE E S S + + S+ + ++ +P + + E SD +
Sbjct: 1689 TSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHK 1748
Query: 2068 -AEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQS 2126
E K +AR L+ + E + EL E +E E E+ +S
Sbjct: 1749 KGESKQQRKARHRPHGPLLPTIEDSSEEEELR------EEEELLKEQEKQREIEQQQRKS 1802
Query: 2127 GGAPPPPG----GKQQGRQCDETPPTSVS--ESAPSQTDSDVPPETEECPSITA---DAN 2177
Q+ R+ +TPP+++S E A + E EE + +
Sbjct: 1803 SSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPS 1862
Query: 2178 IDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALK 2236
I+S+ E I +K + + + P V SP+ D +++ ++ KALK
Sbjct: 1863 IESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPT---------DEQSIMQKEGSQKALK 1912
Score = 45.1 bits (105), Expect = 9e-04
Identities = 217/1147 (18%), Positives = 371/1147 (32%), Gaps = 193/1147 (16%)
Query: 1214 EEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLG 1273
EE++ +A+ K S +S S +++ S P S PP P G
Sbjct: 50 EEERRQIAAVMSRAQGLPKGSVPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPG 109
Query: 1274 ---ERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGS 1330
R+ + + ++ + + ++ + ++ EEH +S L V+ +V+
Sbjct: 110 LSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSV 169
Query: 1331 AGHTPYYQSPTDEKSSHLPT----EVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPD 1386
+ +D ++S T +V++K P E P+ + P
Sbjct: 170 VNKFNPFDLISDSEASQEETTKKQKVVQKEQGKP------------EGIIKPPLQQQPP- 216
Query: 1387 SESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVS 1446
PI K P R P L D ++ P + KS G+ P+
Sbjct: 217 --KPIPKQQGPGRDP------------LQQDGTPKSISSQQPEKIKSQPPGTG---KPIQ 259
Query: 1447 EMTSTSLYQDKQEGKSTDFA--PIKEDFG--QEKKTDDVEAMSSQPALALDERKLGDVSP 1502
T T TD A P++ D Q K+ D V S +P+L SP
Sbjct: 260 GPTQTP---------QTDHAKLPLQRDASRPQTKQADIVRGESVKPSLP---------SP 301
Query: 1503 TQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSF 1562
++ + Q K + E + + P + G T+
Sbjct: 302 SKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKP 361
Query: 1563 PEPTTDDVSPSLHAEVGSPHSTEVDDSLSVS----VVQTPTTFQETEMSPSKEE-CPRPM 1617
P P S+E +++ V +TP P+++ P+P+
Sbjct: 362 PAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPL 421
Query: 1618 SISPPDFSPKTAK--SRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAG 1675
+ P SP A ++TPVQ + I Q P ++ A P G
Sbjct: 422 AQQPGLQSPAKAPGPTKTPVQ----QPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPA 477
Query: 1676 VLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSA 1735
+ GP + P Q S PP ++P T+ + P+ S
Sbjct: 478 KPPPQQPGPAK----PPPQQPGSAK---PPSQQPGSTKP---------PPQQPGPAKPSP 521
Query: 1736 HTPSQIASPLQE--DTLSDVAPPRDMSLYASLTSEKV-QSLEGEKLSPKSDISPLT---P 1789
P P Q+ P A +++ V Q+ G+ L P + +SP P
Sbjct: 522 QQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPT-VSPSAKQPP 580
Query: 1790 RESSPLYSPTFSDSTSAVKEKTATCHSSSSPPIDAASAEPYGFRASVLFDTMQHHLALNR 1849
+ P ++T + + ++ GF + ++ L LN
Sbjct: 581 SQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNC 640
Query: 1850 DLSTPGLEKDSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKI 1909
+ GD + P+ ++ T TS V
Sbjct: 641 QMKRA---------LGGDLAPVPSSPQPKLKTAP-----------VTTTSAVS------- 673
Query: 1910 ERTTKSPSDSGYSYETIGKT--TKTPEDGDYSYEIIEKTTRTPEEGGYSYDISEKTTSPP 1967
+++ P + + K +K PE +K ++ S K PP
Sbjct: 674 -KSSPQPQQTSPKKDAAPKQDLSKAPEP--------KKPPPLVKQPTLHGSPSAKAKQPP 724
Query: 1968 EVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYET 2027
E S + + + D + P TT+ ++S
Sbjct: 725 EADSLSKPAPPKE----PSVPSEQDKAPVADDKPKQPKMVKPTTDLVSS----------- 769
Query: 2028 STKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEA----RQDVDLC 2083
S+ TT+ S+ AE+ T P + + + T EK SP ++ R D
Sbjct: 770 SSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSK 829
Query: 2084 LVS----SCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQG 2139
++S S E K K ++ P P + P ++ KP+ + G+P PPG +
Sbjct: 830 IISHPGPSSESKGQK-QVDPVQKKEEPKKAQTKMSPKPDA-KPMPK--GSPTPPGPRPTA 885
Query: 2140 RQCDETPPTSVSESAPSQTDS-------DVPPETEECPSITADANIDS------EDESET 2186
Q TP S S+ S D P P T + S
Sbjct: 886 GQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNL 945
Query: 2187 IPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTK 2246
I T P AP++ ++P+P P S P++ A K + K +TK
Sbjct: 946 ISTAGQPGPHSQSGPGAPMK-QAPAPSQPPTSQGPPKSTG---QAPPAPAKSIPVKKETK 1001
Query: 2247 KPGT-----KTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKK---KESVEK 2298
P K + + VK+++ + KP D S A P+K +EK
Sbjct: 1002 APAAEKLEPKAEQAPTVKRTETEKKP----------PPIKDSKSLTAEPQKAVLPTKLEK 1051
Query: 2299 AAKPTTT 2305
+ KP +T
Sbjct: 1052 SPKPEST 1058
Score = 40.0 bits (92), Expect = 0.028
Identities = 53/247 (21%), Positives = 103/247 (41%), Gaps = 25/247 (10%)
Query: 523 GQVPTPVVKQTKL--KQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKV 580
G VP + + KQ DS K + +P P + T E+
Sbjct: 69 GSVPPAAAESPSMHRKQELDSSHPPKQSGRP-PDPGRPAQPGLSKSRTTDTFRSEQKLPG 127
Query: 581 ESKEKVMVKKDKP---IKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDV--KPKAAKE 635
S + +K+ K +K E K S+ + S V + V + D+ +A++E
Sbjct: 128 RSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQE 187
Query: 636 KTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKE 695
+T KK+ V+ E K E K +++ PI K++ P ++ ++++ K ++
Sbjct: 188 ETTKKQKVVQKEQGK--PEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTP--KSISSQQ 243
Query: 696 PKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLP--KDAKKSSTPLSEAKKPA 753
P+K +K + P K ++ + P+ + KLP +DA + T ++ +
Sbjct: 244 PEK-IKSQPP----------GTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGE 292
Query: 754 ALKPKVP 760
++KP +P
Sbjct: 293 SVKPSLP 299
Score = 38.9 bits (89), Expect = 0.063
Identities = 65/261 (24%), Positives = 105/261 (40%), Gaps = 44/261 (16%)
Query: 2099 PSFINPNPLEWFASEEPTEESEKPLTQSGGAPP--PPGGKQQGRQCDETPPTSVSESAPS 2156
PS P+P ++ ++S KP++Q+G P PP +Q PP S+ P
Sbjct: 539 PSAQQPSP-----AKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQ----PP---SQGLP- 585
Query: 2157 QTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPD 2216
+T + TE + AN ++ E +T TV + +P+P +
Sbjct: 586 KTICPLCNTTELLLHVPEKANFNTCTECQT-----TV---------CSLCGFNPNPHLTE 631
Query: 2217 VSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTK---SSSPVKKSDGKSKPLAASPK 2273
V E L + + +AL DL + +P KT ++S V KS +P SPK
Sbjct: 632 VK----EWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSS--PQPQQTSPK 685
Query: 2274 PAGLKESSDK--VSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKS 2331
K+++ K +S+ PKK + K +P KA + E D +K A S
Sbjct: 686 ----KDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVP 741
Query: 2332 AKTATAGPGTTKTTKSSAVPP 2352
++ A K + V P
Sbjct: 742 SEQDKAPVADDKPKQPKMVKP 762
Score = 38.5 bits (88), Expect = 0.083
Identities = 119/641 (18%), Positives = 222/641 (34%), Gaps = 99/641 (15%)
Query: 622 EKQATDVKPKAAKEKTVKK-ETKVKPEDKKEE------KEKPKKEVAKKEDKTPIKKEEK 674
++ ATD + + +T K +T V+ +D+ ++ + + K V K D + K
Sbjct: 3449 DEDATDRSYVSRRRRTKKSVDTSVQTDDEDQDEWDMPTRSRRKARVGKYGDSMTEADKTK 3508
Query: 675 PKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKK 734
P + V+ + + EP ++ TP + + K E K + EK K
Sbjct: 3509 PLSKVSSIAVQTVAEISVQTEPVGTIR--TPSIRARVDAKVEIIKHISAPEKTYKGGSLG 3566
Query: 735 LPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEA 794
+A S+ + P L P K++ K +++ A++
Sbjct: 3567 CQTEAD------SDTQSPQYLSATSPPKDK------------KRPTPLEIGYSSHLRADS 3608
Query: 795 VAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI 854
+ + V+ + I+ + P K LE+ P + DI
Sbjct: 3609 TVQLAPSPPKSPKVLYSP-ISPLSPGKALESAFVPYEKP----------------LPDDI 3651
Query: 855 KPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDE---------------GITTT 899
PQ L D K+ P A ++Q+ K + + DE G T
Sbjct: 3652 SPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYTEGYTTKGSQTM 3711
Query: 900 EGEGECEQTPEEL--EPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEED 957
G ++ L P E+ F G + +A+ + + E D
Sbjct: 3712 TSSGAQKKVKRTLPNPPPEEISTGTQSTFSTMGTVSRRRICRTNTMARAKILQDIDRELD 3771
Query: 958 GEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSE 1017
E K DEE + +A K + G +R +E + + EK E +
Sbjct: 3772 LVERESAKLRKKQAELDEEEKEIDA------KLRYLEMGINRRKEALLKEREKRERAYLQ 3825
Query: 1018 EEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSP 1077
A++ D D+ P ++E++ + + E F+ T+ P
Sbjct: 3826 GVAEDRDYMSDSEVSSTRPTRIESQHGI-----ERPRTAPQTEFSQFIPPQTQTESQLVP 3880
Query: 1078 GREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGY-TQSTI----------EI 1126
P + + +++ + + + + E Q S Y TQ T ++
Sbjct: 3881 PTSPYTQYQYSSPALPTQAPTSYTQQSHFEQQTLYHQQVSPYQTQPTFQAVATMSFTPQV 3940
Query: 1127 SSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPL--- 1183
PTP P +M + + P Q + + +S Y ++P + P+
Sbjct: 3941 QPTPTPQPSYQLPSQMMVIQ------QKPRQTTLYLEPKITSNYEVIRNQPLMIAPVSTD 3994
Query: 1184 NGFSE---GSKTDATD---GKDYNASASTISPPSSMEEDKF 1218
N F+ GSK ++ D G + +S ++ SP SS+ D F
Sbjct: 3995 NTFAVSHLGSKYNSLDLRIGLEERSSMAS-SPISSISADSF 4034
Score = 37.7 bits (86), Expect = 0.14
Identities = 50/215 (23%), Positives = 75/215 (34%), Gaps = 22/215 (10%)
Query: 2099 PSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQT 2158
PS P P A +P + P Q G A PP + + P AP T
Sbjct: 381 PSSEQPGPK---ALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPT 437
Query: 2159 DSDVP-PETEECPSITADANIDSEDES-ETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPD 2216
+ V P + P+ A S ++ T P + P PA + P P P
Sbjct: 438 KTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQL-------PGPAKPPPQQPGPAKPP 490
Query: 2217 VSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPA- 2275
P + + K ++ K + S+ P + G +KP A P PA
Sbjct: 491 PQQ--PGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAK 548
Query: 2276 -GLKESSDKVSRVASPKKKESVEKAAKPTTTPEVK 2309
++S+ VS+ S K + PT +P K
Sbjct: 549 PSAQQSTKPVSQTGSGKPLQ------PPTVSPSAK 577
Score = 37.4 bits (85), Expect = 0.18
Identities = 70/289 (24%), Positives = 96/289 (33%), Gaps = 62/289 (21%)
Query: 2118 ESEKPLTQSGGAPPPPG-----GKQQGRQCD----------ETPPTSVSESAPSQTDSDV 2162
+S P QSG PP PG G + R D +P T + + S+TD
Sbjct: 88 DSSHPPKQSG-RPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKE 146
Query: 2163 PPETEECPSITADANI------------------DSE-DESETIPTDKTVTYKHMDP--- 2200
++ P ++ N DSE + ET K V + P
Sbjct: 147 EHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGI 206
Query: 2201 --PPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPV 2258
PP Q P P+ DP + K++ EK K++ PGT P
Sbjct: 207 IKPPLQQQPPKPIPKQQGPGR-DP---LQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPT 262
Query: 2259 K--KSDGKSKPL---AASP--KPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAA 2311
+ ++D PL A+ P K A + + SP K +PT
Sbjct: 263 QTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSK----PPIQQPTPGKPPAQQ 318
Query: 2312 RGEEKDKETKNAANASASKSAKTATAGPGTTK-------TTKSSAVPPG 2353
G EK + A S K PGT K TTK A P G
Sbjct: 319 PGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLG 367
Score = 37.4 bits (85), Expect = 0.18
Identities = 64/304 (21%), Positives = 99/304 (32%), Gaps = 80/304 (26%)
Query: 2111 ASEEPTEESEKPLTQSGGAP------------PPPGGKQQGRQCD----ETPPTSVSESA 2154
AS+E T + +K + + G P P P KQQG D + P S+S
Sbjct: 184 ASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQ 243
Query: 2155 PSQTDSDVP------------PETEECP-SITADAN---------IDSEDESETIPTDKT 2192
P + S P P+T+ + DA+ + E ++P+
Sbjct: 244 PEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSK 303
Query: 2193 VTYKHMDP--PPAPVQDRSPSPRHPDVSMVDPEALA--IEQNLGKALKKDLKEKTKTKKP 2248
+ P PPA S P P L + Q G +K ++ TK P
Sbjct: 304 PPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPG-TVKPPVQPPGTTKPP 362
Query: 2249 GTKTKSSSPVKKSDGKSKPLAASPKPAGLKE--------------SSDKVSRVASPKK-- 2292
+ P + G KP + P P L + + +V +PK
Sbjct: 363 AQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLA 422
Query: 2293 ----KESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSS 2348
+S KA PT TP + G+ ++ AGPG T ++
Sbjct: 423 QQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQ-----------------AGPGKTSAQQTG 465
Query: 2349 AVPP 2352
P
Sbjct: 466 PTKP 469
Score = 36.6 bits (83), Expect = 0.31
Identities = 45/177 (25%), Positives = 68/177 (38%), Gaps = 44/177 (24%)
Query: 1185 GFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSIS 1244
G S G +T+A S SPP +DK + L Y S ++A +T+ + S
Sbjct: 3562 GGSLGCQTEADSDTQSPQYLSATSPP----KDKKRPTPLEIGYSSHLRADSTVQLAPS-- 3615
Query: 1245 AVSSEKVSPSKSPSLSPSPPSPLEKTPL-------GERSVNFSLTPNEIKVSAEAEVAPV 1297
P KSP + SP SPL E+ + ++P ++ A+V P
Sbjct: 3616 --------PPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPA 3667
Query: 1298 SPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIE 1354
SP KT +++ S S P SPT ++SS P + E
Sbjct: 3668 SP----------------KTAKMMQRSMS-------DPKPLSPTADESSRAPFQYTE 3701
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 122 bits (306), Expect = 4e-27
Identities = 310/1401 (22%), Positives = 555/1401 (39%), Gaps = 169/1401 (12%)
Query: 520 DLTGQVPTPVVKQTK-------LKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVN 572
+L G PTP + + + QRA S + L K P+ S K S P +
Sbjct: 1088 NLCGFNPTPHLTEIQEWLCLNCQTQRAISGQ-LGDIRKMPPAPSGPKASPMPVPTESSSQ 1146
Query: 573 HVEKPPKVESKEKVMVKKDKPIKTETKPSVTEK--EVPSKEE-PSPVKAEVAEKQATDVK 629
PP+V K++ K+++ +KTE + + EK E S E+ P V + ++++ K
Sbjct: 1147 KTAVPPQV----KLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEK 1202
Query: 630 PKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVK--KEVKKE 687
KA+ +E K PE+KK P++E + E+K P+ +E+KP E+ K E K
Sbjct: 1203 DKAS----ALQEKKPLPEEKKLI---PEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTS 1255
Query: 688 IKKEEKKEPKK---EVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSST 744
+E+K + K ++ +E V + +E K+ K E P + LPK+ K++
Sbjct: 1256 APEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTK 1315
Query: 745 PLSEAKKP-AALKPKV--PKKEESVKKDSVAAGKPKEKGKI-KVIKKEGKAAEAVAAAVG 800
+ E +P KP P KE++ K+D + ++ K + + G +++ +++++G
Sbjct: 1316 TIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLG 1375
Query: 801 TGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLEL 860
+ + G K+ ++ S SSP DL K E V ++ Q
Sbjct: 1376 E--IPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAK-------LESTVLSILEAQAST 1426
Query: 861 IEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPV-EKQG 919
+ DE+ K+T+P E + E+ + +S E + T E E +++ EE + +K
Sbjct: 1427 LADEKSEKKTQPHE---VSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDS 1483
Query: 920 VDDIEKFED--EGAGFEESSET-----GDYEEKAETEEAEEPEEDGEEHVCVSASKHSPT 972
DI +D E + F + T EE +E+E + P+ V S+S
Sbjct: 1484 QQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQ 1543
Query: 973 EDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREE 1032
ED + + E D +IR++ +++ +D + + DE I E S ++ + + +
Sbjct: 1544 EDSQGSGEEED-FIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGK 1602
Query: 1033 EYEPEKMEAEDYVMAVVDKAA---EAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDET 1089
+ +D+ A + E+ F +P + RE S +E
Sbjct: 1603 ITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKY------RETKSQESEEL 1656
Query: 1090 LPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNN 1149
+ G E ++++A S ++++ EP EM + D D +
Sbjct: 1657 VVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPEL--EMESLTDSPEDRSRG 1714
Query: 1150 EETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISP 1209
E S S + T S + +D +P + E + + + TI
Sbjct: 1715 EG--SSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIED 1772
Query: 1210 PSSMEEDKFSRSAL------RDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSP 1263
S EE + L R+ + K+S+ KD + + K+P PS
Sbjct: 1773 SSEEEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTP---PSN 1829
Query: 1264 PSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSP 1323
SP+E E + + E+ S+ +E +P S E E E SPE K +EV
Sbjct: 1830 LSPIEDASPTEE-LRQAAEMEELHRSSCSEYSP-SIESDPEGFE---ISPE-KIIEVQKV 1883
Query: 1324 SQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEP 1383
+ T + + SPTDE+S +++K + + +E + P
Sbjct: 1884 YKLPTAVSLY-----SPTDEQS------IMQKEGSQKALKSAEEMYEEMMHKTHKYKAFP 1932
Query: 1384 VPDSESPI-EKVLSPLRSPPLIGSESAYESFLSADDKASGRGA-------ESPFEEKSGK 1435
+ + EK PL LI + YES + S G+ E+ F ++ G+
Sbjct: 1933 AANERDEVFEK--EPLYGGMLI-EDYIYESLVEDTYNGSVDGSLLTRQEEENGFMQQKGR 1989
Query: 1436 QGS---PDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEK----KTDDVEAMSSQP 1488
+ +Q+ T L ++ E +S +ED ++ ++ + +
Sbjct: 1990 EQKIRLSEQIYEDPMQKITDLQKEFYELESLHSVVPQEDIVSSSFIIPESHEIVDLGTMV 2049
Query: 1489 ALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTY----- 1543
+ERKL D + + + +M ++ G S + P+ E + E T
Sbjct: 2050 TSTEEERKLLDAD------AAYEELMKRQQMQLTPG--SSPTQAPIGEDMTESTMDFDRM 2101
Query: 1544 -------SHMEGVASVSTASVATSSFPEP--TTDDVSPSLHAEVGSPHSTEVDDSLS-VS 1593
S + G + + S AT S P+ T + + E + ++ E+ + ++ S
Sbjct: 2102 PDASLTSSVLSGASLTDSTSSATLSIPDVKITQHFSTEEIEDEYVTDYTREIQEIIAHES 2161
Query: 1594 VVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS------EQSSMSI 1647
++ T + E+ S + P S++ S T S +P+ S E M
Sbjct: 2162 LILTYSEPSESATSVPPSDTP---SLTSSVSSVCTTDSSSPITTLDSITTVYTEPVDMIT 2218
Query: 1648 EFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITE--NGPTEVDY---SPSDMQDSSLSHK 1702
+F ++S E S + F D+P + L T +G D+ S SDM S +
Sbjct: 2219 KF-EDSEEISSSTYFPGSIIDYPEEISVSLDRTAPPDGRASADHIVISLSDMASSIIESV 2277
Query: 1703 IPPMEEP-SYTQDNDLSELISVSQVEASP-STSSAHTPSQIASPLQEDTLSDVAPPRDMS 1760
+P E P + T DL LIS E P + T + I + E RD
Sbjct: 2278 VPKPEGPVADTVSTDL--LIS----EKDPVKKAKKETGNGIILEVLEAY-------RDKK 2324
Query: 1761 LYASLTSEKVQSLEGEKL--SPKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSS 1818
L +E+ +S E + P S + L +E L + F+ + +EK A+ S
Sbjct: 2325 ---ELEAERTKSSLSETVFDHPPSSVIALPMKEQ--LSTTYFTSGETFGQEKPASQLPSG 2379
Query: 1819 SPPIDAASAEPYGFRASVLFD 1839
SP + + A+P F S D
Sbjct: 2380 SPSVSSLPAKPRPFFRSSSLD 2400
Score = 102 bits (254), Expect = 5e-21
Identities = 265/1334 (19%), Positives = 482/1334 (36%), Gaps = 191/1334 (14%)
Query: 526 PTPVVKQTKLKQRADSRESLKPAAKPLPSK------SVRKESKEETPEVTKVNHVEKPPK 579
P P Q KLK + S + P P + + K+ + PE K + K P
Sbjct: 652 PVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPT 711
Query: 580 VESKEKVMVKKDKPIKTETKPS-VTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTV 638
+ K+ + +KP+ E VPS+++ +PV A+ KQ VKP +
Sbjct: 712 LHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPV-ADDKPKQPKMVKPTTDLVSSS 770
Query: 639 KKETKVK-PEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPK 697
TK P K + + + K K D + P E+V K I +
Sbjct: 771 SATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPR--PASDS 828
Query: 698 KEVKKETPPKEVK--KEVKKEEKKEVKKE---EKEPKKEIKKLPKDAKKSSTPLSEAKKP 752
K + P E K K+V +KKE K+ + PK + K +PK + P A +
Sbjct: 829 KIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQT 888
Query: 753 AALKPKVPKKEESVKKDSVAAGK----PKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAV 808
+ PK +E ++ S+ G PK + GK A+ + +
Sbjct: 889 VPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLIST 948
Query: 809 MAAAG-IAAIGPAKELE-----AERSLMSSPEDLTKDFEELKAEEVDVTKDIK-PQLELI 861
G + GP ++ ++ P T A+ + V K+ K P E +
Sbjct: 949 AGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKL 1008
Query: 862 EDEEK----LKETE-PVEAYVIQKEREVTKGPAES--PDEGITTTEGEGECEQTPEEL-- 912
E + + +K TE + I+ + +T P ++ P + + + E C EL
Sbjct: 1009 EPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNI 1068
Query: 913 ---EPVEKQGVDDIEKFEDEGAGFEESSETGDYEE----KAETEEA-------------- 951
+P + + GF + + +E +T+ A
Sbjct: 1069 GSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPA 1128
Query: 952 ---------EEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEE 1002
P E + V + E+ K EA+ I EK + S
Sbjct: 1129 PSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLS------- 1181
Query: 1003 DMDEAIEKGEAEQSEEEAD-EEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQ 1061
M++ +Q +EE+ E+DKA +E++ PE+ + + E +EE+
Sbjct: 1182 -MEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKK--------LIPEEEKIRSEEK 1232
Query: 1062 YGFL-----TTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTAT 1116
L T K+L ++ P HD +S+ + EE E + T
Sbjct: 1233 KPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLL-----KSQVQIA-EEKLEGRVAPKTVQ 1286
Query: 1117 SGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSK 1176
G Q ++ P+ + D + +T E+ + P +K
Sbjct: 1287 EG-KQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCT-----------------AK 1328
Query: 1177 PADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTT 1236
P V P KT+ D K +S+ P + + +S + + E+ +
Sbjct: 1329 PDQVEP-----GKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSS-LGEIPSLIP 1382
Query: 1237 LDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP 1296
D KD + + + S SPS SPS + LE T L EA+ +
Sbjct: 1383 TDEKDILKGLKKDSFSQESSPS-SPSDLAKLESTVLS---------------ILEAQAST 1426
Query: 1297 VSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKP 1356
++ E +++ + H SPE + +QS++ + T + + + T +
Sbjct: 1427 LADEKSEKKTQPHEVSPEQPKDQ--EKTQSLSETLEITISEEEIKESQEERKDTFKKDSQ 1484
Query: 1357 PAVPVSFEFSDAKDENERA-SVSPMDEPVPDSESPIEKVLSPL---RSPPLIGSESAYES 1412
+P S D K+++E ++ EP E E SP+ + +GS S+ +
Sbjct: 1485 QDIPSS---KDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSS-DE 1540
Query: 1413 FLSADDKASGRGAE---------SPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQE---- 1459
+ D + SG + S E+ SG + + + E++S++ Q K+E
Sbjct: 1541 YKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGK 1600
Query: 1460 GKST----------DFAPIKEDFGQEKK--TDDVEAMSSQPALALDERKLGDVSPTQIDV 1507
GK T I ED G+ +D EA P L E K ++ V
Sbjct: 1601 GKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETK--SQESEELVV 1658
Query: 1508 SQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTT 1567
+ G + + ++ T++DK + E + T + + + S+ T S + +
Sbjct: 1659 TGGGGLRRFKTIELN-STIADKYSA---ESSQKKTSLYFDEEPELEMESL-TDSPEDRSR 1713
Query: 1568 DDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPK 1627
+ S SLHA +P ++ S + + ++ E ++ RP P
Sbjct: 1714 GEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDS 1773
Query: 1628 TAKSRTPVQDHRSEQSSMSIEFGQESPEQS----------LAMDFSRQSPDHPTVGAGVL 1677
+ + ++ ++ E Q+ + S L R+ P P + +
Sbjct: 1774 SEEEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPP--SNLS 1831
Query: 1678 HITENGPTEVDYSPSDMQD---SSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSS 1734
I + PTE ++M++ SS S P +E + ++I V +V P+ S
Sbjct: 1832 PIEDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVS 1891
Query: 1735 AHTPSQIASPLQED 1748
++P+ S +Q++
Sbjct: 1892 LYSPTDEQSIMQKE 1905
Score = 70.5 bits (171), Expect = 2e-11
Identities = 348/1859 (18%), Positives = 658/1859 (35%), Gaps = 316/1859 (16%)
Query: 503 EKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSR------------ESLKPAAK 550
EK+K QP T K + G TP KL + D+ ES+KP+
Sbjct: 245 EKIK-----SQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSL- 298
Query: 551 PLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSK 610
P PSK ++ P + H + P P K +PS K P
Sbjct: 299 PSPSKPPIQQPTPGKPPAQQPGHEKSQPG-------------PAKPPAQPSGLTK--PLA 343
Query: 611 EEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKED--KTP 668
++P VK V T KP A K + +K ++ K +A+ KTP
Sbjct: 344 QQPGTVKPPVQPPGTT--KPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTP 401
Query: 669 IKKE--EKPKKEEV---KKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKK 723
++ KP ++V K ++ + K P P K ++ +
Sbjct: 402 AQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSA 461
Query: 724 EEKEPKKEIKKLPKDAKKSSTPLSEAK----KPAALKP--------KVPKKEESVKKDSV 771
++ P K +LP AK AK +P + KP K P ++ K S
Sbjct: 462 QQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPS- 520
Query: 772 AAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMS 831
P++ G K ++ +A+ +A + A +A + ++ G K L+ S
Sbjct: 521 ----PQQPGSTKPPSQQPGSAKP-SAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPS 575
Query: 832 SPEDLTKDFEELKAEEVDVTK-------------------------DIKPQLELIEDEEK 866
+ + ++ + + T+ P L E +E
Sbjct: 576 AKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEW 635
Query: 867 LKETEPVEAYVIQKEREVTKGPAESPDEG-ITTTEGEGECEQTPEELEPVE----KQGVD 921
L ++ + V P +TTT + P++ P + KQ +
Sbjct: 636 LCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLS 695
Query: 922 DIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESA--- 978
+ + ++ + G KA+ + PE D P+E +++
Sbjct: 696 KAPEPKKPPPLVKQPTLHGSPSAKAK----QPPEADSLSKPAPPKEPSVPSEQDKAPVAD 751
Query: 979 -KAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPE 1037
K + ++ + V+S + D+ + + +AE+ + D A+ ++ E
Sbjct: 752 DKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGE 811
Query: 1038 KMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESE 1097
K+ D KA ++ + P+ ++S G++ + + P ++++
Sbjct: 812 KVSPFD------SKAIPRPASDSKIISHPGPS----SESKGQKQVDPVQKKEEPKKAQTK 861
Query: 1098 AT----ASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDE-MSTPRDVMSDETNNEET 1152
+ A P T+G T T + S +P S ++D ++ T
Sbjct: 862 MSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPT 921
Query: 1153 ESPSQEFVNITKYESSLYSQE------------YSKPADVTPLNGFSEGSKTDATDGKDY 1200
+ + +S++SQ +S+ P+ S+ + G
Sbjct: 922 TPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPK 981
Query: 1201 NASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLS 1260
+ + +P S+ K +++ + E KA +K + + + SKS +
Sbjct: 982 STGQAPPAPAKSIPVKKETKAPAAEKL--EPKAEQAPTVKRTETEKKPPPIKDSKSLTAE 1039
Query: 1261 PSP---PSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKT 1317
P P+ LEK+P E + T I S + E +V +P
Sbjct: 1040 PQKAVLPTKLEKSPKPESTCPLCKTELNIG-SKDPPNFNTCTECKNQVCNLCGFNPTPHL 1098
Query: 1318 LEV-------VSPSQSVTGSAGHTPYYQ-SPTDEKSSHLP--TEVIEKPPAVPVSFEFSD 1367
E+ ++++G G +P+ K+S +P TE + AVP +
Sbjct: 1099 TEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVK 1158
Query: 1368 AKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAES 1427
+++ + + +++ LS + PP++ ++ E DKAS +
Sbjct: 1159 KQEQEVKTEAEKV------ILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKK 1212
Query: 1428 PFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQ 1487
P E+ L ++++ +S + P+ E ++K T + + + +
Sbjct: 1213 PLPEEK------------------KLIPEEEKIRSEEKKPLLE---EKKPTPEDKKLLPE 1251
Query: 1488 PALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHME 1547
+ E + D+ +Q+ +++ EG V+ K+ V EG T ME
Sbjct: 1252 AKTSAPEEQKHDLLKSQVQIAE----------EKLEGRVAPKT---VQEGKQPQT--KME 1296
Query: 1548 GVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMS 1607
G+ S G+P S +D + +
Sbjct: 1297 GLPS---------------------------GTPQSLPKEDDKTTKTI------------ 1317
Query: 1608 PSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSP 1667
+E P+P + PD + K +T +D +S+ SS + P+ + + S
Sbjct: 1318 ---KEQPQPPCTAKPD-QVEPGKEKTEKEDDKSDTSS------SQQPKSPQGLSDTGYSS 1367
Query: 1668 DHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVE 1727
D + G + P+ + P+D +D + +++ S++Q++ S ++++E
Sbjct: 1368 DGISSSLGEI------PSLI---PTDEKDI-----LKGLKKDSFSQESSPSSPSDLAKLE 1413
Query: 1728 ASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPL 1787
ST + +Q AS L ++ P ++S EK QSL E L + IS
Sbjct: 1414 ---STVLSILEAQ-ASTLADEKSEKKTQPHEVSPEQPKDQEKTQSL-SETL--EITISEE 1466
Query: 1788 TPRESSPLYSPTF-SDSTSAVKEKTATCHSSSSPPID--AASAEPYGFRASVLFDTMQHH 1844
+ES TF DS + ++ H S +D EPY D+++
Sbjct: 1467 EIKESQEERKDTFKKDSQQDI--PSSKDHKEKSEFVDDITTRREPY--------DSVEES 1516
Query: 1845 LALNRDLSTPGLEKDSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGY 1904
+ S G + D K E++ S +EED+ + + + D G
Sbjct: 1517 SESENSPVPQRKRRTSVGSSSSD----EYKQEDSQGSGEEEDFIRKQIIEMSADEDASGS 1572
Query: 1905 YYEKIERT----TKSPSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSY--- 1957
++ R S ++S ET GK T G + + +T E+ G +
Sbjct: 1573 EDDEFIRNQLKEISSSTESQKKEETKGKGKITA--GKHRRLTRKSSTSIDEDAGRRHSWH 1630
Query: 1958 -DISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYD--DSEDGGHTLGDPSYSYETTEKI 2014
+ E PE+ Y K++ S L+ G + + T+ D YS E+++K
Sbjct: 1631 DEDDEAFDESPELK-YRETKSQESEELVVTGGGGLRRFKTIELNSTIAD-KYSAESSQKK 1688
Query: 2015 TSF-----PESEGYSYETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYT-- 2067
TS PE E S S + + S+ + ++ +P + + E SD +
Sbjct: 1689 TSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHK 1748
Query: 2068 -AEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQS 2126
E K +AR L+ + E + EL E +E E E+ +S
Sbjct: 1749 KGESKQQRKARHRPHGPLLPTIEDSSEEEELR------EEEELLKEQEKQREIEQQQRKS 1802
Query: 2127 GGAPPPPG----GKQQGRQCDETPPTSVS--ESAPSQTDSDVPPETEECPSITA---DAN 2177
Q+ R+ +TPP+++S E A + E EE + +
Sbjct: 1803 SSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPS 1862
Query: 2178 IDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALK 2236
I+S+ E I +K + + + P V SP+ D +++ ++ KALK
Sbjct: 1863 IESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPT---------DEQSIMQKEGSQKALK 1912
Score = 45.1 bits (105), Expect = 9e-04
Identities = 217/1147 (18%), Positives = 371/1147 (32%), Gaps = 193/1147 (16%)
Query: 1214 EEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLG 1273
EE++ +A+ K S +S S +++ S P S PP P G
Sbjct: 50 EEERRQIAAVMSRAQGLPKGSVPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPG 109
Query: 1274 ---ERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGS 1330
R+ + + ++ + + ++ + ++ EEH +S L V+ +V+
Sbjct: 110 LSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSV 169
Query: 1331 AGHTPYYQSPTDEKSSHLPT----EVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPD 1386
+ +D ++S T +V++K P E P+ + P
Sbjct: 170 VNKFNPFDLISDSEASQEETTKKQKVVQKEQGKP------------EGIIKPPLQQQPP- 216
Query: 1387 SESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVS 1446
PI K P R P L D ++ P + KS G+ P+
Sbjct: 217 --KPIPKQQGPGRDP------------LQQDGTPKSISSQQPEKIKSQPPGTG---KPIQ 259
Query: 1447 EMTSTSLYQDKQEGKSTDFA--PIKEDFG--QEKKTDDVEAMSSQPALALDERKLGDVSP 1502
T T TD A P++ D Q K+ D V S +P+L SP
Sbjct: 260 GPTQTP---------QTDHAKLPLQRDASRPQTKQADIVRGESVKPSLP---------SP 301
Query: 1503 TQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSF 1562
++ + Q K + E + + P + G T+
Sbjct: 302 SKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKP 361
Query: 1563 PEPTTDDVSPSLHAEVGSPHSTEVDDSLSVS----VVQTPTTFQETEMSPSKEE-CPRPM 1617
P P S+E +++ V +TP P+++ P+P+
Sbjct: 362 PAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPL 421
Query: 1618 SISPPDFSPKTAK--SRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAG 1675
+ P SP A ++TPVQ + I Q P ++ A P G
Sbjct: 422 AQQPGLQSPAKAPGPTKTPVQ----QPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPA 477
Query: 1676 VLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSA 1735
+ GP + P Q S PP ++P T+ + P+ S
Sbjct: 478 KPPPQQPGPAK----PPPQQPGSAK---PPSQQPGSTKP---------PPQQPGPAKPSP 521
Query: 1736 HTPSQIASPLQE--DTLSDVAPPRDMSLYASLTSEKV-QSLEGEKLSPKSDISPLT---P 1789
P P Q+ P A +++ V Q+ G+ L P + +SP P
Sbjct: 522 QQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPT-VSPSAKQPP 580
Query: 1790 RESSPLYSPTFSDSTSAVKEKTATCHSSSSPPIDAASAEPYGFRASVLFDTMQHHLALNR 1849
+ P ++T + + ++ GF + ++ L LN
Sbjct: 581 SQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNC 640
Query: 1850 DLSTPGLEKDSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKI 1909
+ GD + P+ ++ T TS V
Sbjct: 641 QMKRA---------LGGDLAPVPSSPQPKLKTAP-----------VTTTSAVS------- 673
Query: 1910 ERTTKSPSDSGYSYETIGKT--TKTPEDGDYSYEIIEKTTRTPEEGGYSYDISEKTTSPP 1967
+++ P + + K +K PE +K ++ S K PP
Sbjct: 674 -KSSPQPQQTSPKKDAAPKQDLSKAPEP--------KKPPPLVKQPTLHGSPSAKAKQPP 724
Query: 1968 EVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYET 2027
E S + + + D + P TT+ ++S
Sbjct: 725 EADSLSKPAPPKE----PSVPSEQDKAPVADDKPKQPKMVKPTTDLVSS----------- 769
Query: 2028 STKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEA----RQDVDLC 2083
S+ TT+ S+ AE+ T P + + + T EK SP ++ R D
Sbjct: 770 SSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSK 829
Query: 2084 LVS----SCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQG 2139
++S S E K K ++ P P + P ++ KP+ + G+P PPG +
Sbjct: 830 IISHPGPSSESKGQK-QVDPVQKKEEPKKAQTKMSPKPDA-KPMPK--GSPTPPGPRPTA 885
Query: 2140 RQCDETPPTSVSESAPSQTDS-------DVPPETEECPSITADANIDS------EDESET 2186
Q TP S S+ S D P P T + S
Sbjct: 886 GQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNL 945
Query: 2187 IPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTK 2246
I T P AP++ ++P+P P S P++ A K + K +TK
Sbjct: 946 ISTAGQPGPHSQSGPGAPMK-QAPAPSQPPTSQGPPKSTG---QAPPAPAKSIPVKKETK 1001
Query: 2247 KPGT-----KTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKK---KESVEK 2298
P K + + VK+++ + KP D S A P+K +EK
Sbjct: 1002 APAAEKLEPKAEQAPTVKRTETEKKP----------PPIKDSKSLTAEPQKAVLPTKLEK 1051
Query: 2299 AAKPTTT 2305
+ KP +T
Sbjct: 1052 SPKPEST 1058
Score = 40.0 bits (92), Expect = 0.028
Identities = 53/247 (21%), Positives = 103/247 (41%), Gaps = 25/247 (10%)
Query: 523 GQVPTPVVKQTKL--KQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKV 580
G VP + + KQ DS K + +P P + T E+
Sbjct: 69 GSVPPAAAESPSMHRKQELDSSHPPKQSGRP-PDPGRPAQPGLSKSRTTDTFRSEQKLPG 127
Query: 581 ESKEKVMVKKDKP---IKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDV--KPKAAKE 635
S + +K+ K +K E K S+ + S V + V + D+ +A++E
Sbjct: 128 RSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQE 187
Query: 636 KTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKE 695
+T KK+ V+ E K E K +++ PI K++ P ++ ++++ K ++
Sbjct: 188 ETTKKQKVVQKEQGK--PEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTP--KSISSQQ 243
Query: 696 PKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLP--KDAKKSSTPLSEAKKPA 753
P+K +K + P K ++ + P+ + KLP +DA + T ++ +
Sbjct: 244 PEK-IKSQPP----------GTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGE 292
Query: 754 ALKPKVP 760
++KP +P
Sbjct: 293 SVKPSLP 299
Score = 38.9 bits (89), Expect = 0.063
Identities = 65/261 (24%), Positives = 105/261 (40%), Gaps = 44/261 (16%)
Query: 2099 PSFINPNPLEWFASEEPTEESEKPLTQSGGAPP--PPGGKQQGRQCDETPPTSVSESAPS 2156
PS P+P ++ ++S KP++Q+G P PP +Q PP S+ P
Sbjct: 539 PSAQQPSP-----AKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQ----PP---SQGLP- 585
Query: 2157 QTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPD 2216
+T + TE + AN ++ E +T TV + +P+P +
Sbjct: 586 KTICPLCNTTELLLHVPEKANFNTCTECQT-----TV---------CSLCGFNPNPHLTE 631
Query: 2217 VSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTK---SSSPVKKSDGKSKPLAASPK 2273
V E L + + +AL DL + +P KT ++S V KS +P SPK
Sbjct: 632 VK----EWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSS--PQPQQTSPK 685
Query: 2274 PAGLKESSDK--VSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKS 2331
K+++ K +S+ PKK + K +P KA + E D +K A S
Sbjct: 686 ----KDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVP 741
Query: 2332 AKTATAGPGTTKTTKSSAVPP 2352
++ A K + V P
Sbjct: 742 SEQDKAPVADDKPKQPKMVKP 762
Score = 38.5 bits (88), Expect = 0.083
Identities = 119/641 (18%), Positives = 222/641 (34%), Gaps = 99/641 (15%)
Query: 622 EKQATDVKPKAAKEKTVKK-ETKVKPEDKKEE------KEKPKKEVAKKEDKTPIKKEEK 674
++ ATD + + +T K +T V+ +D+ ++ + + K V K D + K
Sbjct: 3449 DEDATDRSYVSRRRRTKKSVDTSVQTDDEDQDEWDMPTRSRRKARVGKYGDSMTEADKTK 3508
Query: 675 PKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKK 734
P + V+ + + EP ++ TP + + K E K + EK K
Sbjct: 3509 PLSKVSSIAVQTVAEISVQTEPVGTIR--TPSIRARVDAKVEIIKHISAPEKTYKGGSLG 3566
Query: 735 LPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEA 794
+A S+ + P L P K++ K +++ A++
Sbjct: 3567 CQTEAD------SDTQSPQYLSATSPPKDK------------KRPTPLEIGYSSHLRADS 3608
Query: 795 VAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI 854
+ + V+ + I+ + P K LE+ P + DI
Sbjct: 3609 TVQLAPSPPKSPKVLYSP-ISPLSPGKALESAFVPYEKP----------------LPDDI 3651
Query: 855 KPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDE---------------GITTT 899
PQ L D K+ P A ++Q+ K + + DE G T
Sbjct: 3652 SPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYTEGYTTKGSQTM 3711
Query: 900 EGEGECEQTPEEL--EPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEED 957
G ++ L P E+ F G + +A+ + + E D
Sbjct: 3712 TSSGAQKKVKRTLPNPPPEEISTGTQSTFSTMGTVSRRRICRTNTMARAKILQDIDRELD 3771
Query: 958 GEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSE 1017
E K DEE + +A K + G +R +E + + EK E +
Sbjct: 3772 LVERESAKLRKKQAELDEEEKEIDA------KLRYLEMGINRRKEALLKEREKRERAYLQ 3825
Query: 1018 EEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSP 1077
A++ D D+ P ++E++ + + E F+ T+ P
Sbjct: 3826 GVAEDRDYMSDSEVSSTRPTRIESQHGI-----ERPRTAPQTEFSQFIPPQTQTESQLVP 3880
Query: 1078 GREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGY-TQSTI----------EI 1126
P + + +++ + + + + E Q S Y TQ T ++
Sbjct: 3881 PTSPYTQYQYSSPALPTQAPTSYTQQSHFEQQTLYHQQVSPYQTQPTFQAVATMSFTPQV 3940
Query: 1127 SSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPL--- 1183
PTP P +M + + P Q + + +S Y ++P + P+
Sbjct: 3941 QPTPTPQPSYQLPSQMMVIQ------QKPRQTTLYLEPKITSNYEVIRNQPLMIAPVSTD 3994
Query: 1184 NGFSE---GSKTDATD---GKDYNASASTISPPSSMEEDKF 1218
N F+ GSK ++ D G + +S ++ SP SS+ D F
Sbjct: 3995 NTFAVSHLGSKYNSLDLRIGLEERSSMAS-SPISSISADSF 4034
Score = 37.7 bits (86), Expect = 0.14
Identities = 50/215 (23%), Positives = 75/215 (34%), Gaps = 22/215 (10%)
Query: 2099 PSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQT 2158
PS P P A +P + P Q G A PP + + P AP T
Sbjct: 381 PSSEQPGPK---ALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPT 437
Query: 2159 DSDVP-PETEECPSITADANIDSEDES-ETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPD 2216
+ V P + P+ A S ++ T P + P PA + P P P
Sbjct: 438 KTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQL-------PGPAKPPPQQPGPAKPP 490
Query: 2217 VSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPA- 2275
P + + K ++ K + S+ P + G +KP A P PA
Sbjct: 491 PQQ--PGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAK 548
Query: 2276 -GLKESSDKVSRVASPKKKESVEKAAKPTTTPEVK 2309
++S+ VS+ S K + PT +P K
Sbjct: 549 PSAQQSTKPVSQTGSGKPLQ------PPTVSPSAK 577
Score = 37.4 bits (85), Expect = 0.18
Identities = 70/289 (24%), Positives = 96/289 (33%), Gaps = 62/289 (21%)
Query: 2118 ESEKPLTQSGGAPPPPG-----GKQQGRQCD----------ETPPTSVSESAPSQTDSDV 2162
+S P QSG PP PG G + R D +P T + + S+TD
Sbjct: 88 DSSHPPKQSG-RPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKE 146
Query: 2163 PPETEECPSITADANI------------------DSE-DESETIPTDKTVTYKHMDP--- 2200
++ P ++ N DSE + ET K V + P
Sbjct: 147 EHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGI 206
Query: 2201 --PPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPV 2258
PP Q P P+ DP + K++ EK K++ PGT P
Sbjct: 207 IKPPLQQQPPKPIPKQQGPGR-DP---LQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPT 262
Query: 2259 K--KSDGKSKPL---AASP--KPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAA 2311
+ ++D PL A+ P K A + + SP K +PT
Sbjct: 263 QTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSK----PPIQQPTPGKPPAQQ 318
Query: 2312 RGEEKDKETKNAANASASKSAKTATAGPGTTK-------TTKSSAVPPG 2353
G EK + A S K PGT K TTK A P G
Sbjct: 319 PGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLG 367
Score = 37.4 bits (85), Expect = 0.18
Identities = 64/304 (21%), Positives = 99/304 (32%), Gaps = 80/304 (26%)
Query: 2111 ASEEPTEESEKPLTQSGGAP------------PPPGGKQQGRQCD----ETPPTSVSESA 2154
AS+E T + +K + + G P P P KQQG D + P S+S
Sbjct: 184 ASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQ 243
Query: 2155 PSQTDSDVP------------PETEECP-SITADAN---------IDSEDESETIPTDKT 2192
P + S P P+T+ + DA+ + E ++P+
Sbjct: 244 PEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSK 303
Query: 2193 VTYKHMDP--PPAPVQDRSPSPRHPDVSMVDPEALA--IEQNLGKALKKDLKEKTKTKKP 2248
+ P PPA S P P L + Q G +K ++ TK P
Sbjct: 304 PPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPG-TVKPPVQPPGTTKPP 362
Query: 2249 GTKTKSSSPVKKSDGKSKPLAASPKPAGLKE--------------SSDKVSRVASPKK-- 2292
+ P + G KP + P P L + + +V +PK
Sbjct: 363 AQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLA 422
Query: 2293 ----KESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSS 2348
+S KA PT TP + G+ ++ AGPG T ++
Sbjct: 423 QQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQ-----------------AGPGKTSAQQTG 465
Query: 2349 AVPP 2352
P
Sbjct: 466 PTKP 469
Score = 36.6 bits (83), Expect = 0.31
Identities = 45/177 (25%), Positives = 68/177 (38%), Gaps = 44/177 (24%)
Query: 1185 GFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSIS 1244
G S G +T+A S SPP +DK + L Y S ++A +T+ + S
Sbjct: 3562 GGSLGCQTEADSDTQSPQYLSATSPP----KDKKRPTPLEIGYSSHLRADSTVQLAPS-- 3615
Query: 1245 AVSSEKVSPSKSPSLSPSPPSPLEKTPL-------GERSVNFSLTPNEIKVSAEAEVAPV 1297
P KSP + SP SPL E+ + ++P ++ A+V P
Sbjct: 3616 --------PPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPA 3667
Query: 1298 SPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIE 1354
SP KT +++ S S P SPT ++SS P + E
Sbjct: 3668 SP----------------KTAKMMQRSMS-------DPKPLSPTADESSRAPFQYTE 3701
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 115 bits (287), Expect = 7e-25
Identities = 292/1444 (20%), Positives = 523/1444 (36%), Gaps = 211/1444 (14%)
Query: 457 QEVDLPISYLTSVSSLIVWHPANPA-----EKIIRVLFPGNSTQYNILEGLEKLKHLDFL 511
+E + ++ + VS IV P P+ E++I V P T+ ++ EK+
Sbjct: 9197 EEEKVQVTKVPEVSKKIV--PQKPSRTPVQEEVIEVKVPAVHTKKMVISE-EKMFFASHT 9253
Query: 512 KQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKE------SKEET 565
++ ++ +V +V + K+ R P LP K +E K+
Sbjct: 9254 EEEVSVT---VPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVE 9310
Query: 566 PEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPV--KAEVAEK 623
P KV V K P E K+ V V K +P P V +K VP ++ P PV K E
Sbjct: 9311 PPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPA 9370
Query: 624 QATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKE 683
+ +V+ E+ + T+ + E PKK+V ++ P K+EE P +V
Sbjct: 9371 KVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPAL 9430
Query: 684 VKKEIKKEEKKEPKKEVKKETPPK-EVKKEVKKEEKKEVKKEEKE---PKKEIKKLPKDA 739
KK + +E+ P KK PP+ EV K+ EEK+ V +E+ P++ + +
Sbjct: 9431 PKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVS 9490
Query: 740 KKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKE----GKAAEAV 795
+ SE ++ ++ ++ E ++ V + E+ + V++++ K EA
Sbjct: 9491 AEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAE 9550
Query: 796 AAAVGTGATTAAVM---AAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTK 852
A V V+ A I PAK EA + ++ + ++ K V +
Sbjct: 9551 PAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPE 9610
Query: 853 D-IKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEG--EGECEQTP 909
+ KP E + +K EP+ A V ++ ++T+ E +T E + + P
Sbjct: 9611 EPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQ--EEKVLVAVTKKEAPPKARVPEEP 9668
Query: 910 EELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKH 969
+ P EK ++ E+ A E + EEK E + + +E + +
Sbjct: 9669 KRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKER 9728
Query: 970 SPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDA 1029
+ T +EE+ + + E+ E D + E+ + E + E+ EE E ++ E+
Sbjct: 9729 AYTLEEEAVSVQRE----EEYEEYEEYDYKEFEEYEPTEEYDQYEEYEER--EYERYEEH 9782
Query: 1030 REEEYEPEK----MEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPG--REPAS 1083
E EPEK + + KA A ++ P +++ P + P
Sbjct: 9783 EEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKK-----AVPEEKVPVPIPKKLKPPPP 9837
Query: 1084 SIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMS------ 1137
+ +E E + + +E E + + P P E++
Sbjct: 9838 KVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVP 9897
Query: 1138 -TPRDVMSDETNNEETESPSQEFVNITKYESSLYSQE----YSKPADVTPLNGFSEGSKT 1192
P+++ +E EE E + + E ++ +E + V P+ K
Sbjct: 9898 EVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKP 9957
Query: 1193 DATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVS 1252
+ K +PP+ + E + K + EK
Sbjct: 9958 VPEEKKPVPVPKKKEAPPAKVPE-----------------VPKKPEEKVPVLIPKKEKPP 10000
Query: 1253 PSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCAS 1312
P+K P + P P P EK P+ P KV A P P+ + V E+
Sbjct: 10001 PAKVPEV-PKKPVPEEKVPV----------PVPKKVEAPPAKVPEVPK--KPVPEKKVPV 10047
Query: 1313 PEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPP-------AVPVSFEF 1365
P K +E +P V P P ++K + +P +V PP VPV
Sbjct: 10048 PAPKKVE--APPAKVP----EVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVAL 10101
Query: 1366 SDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGA 1425
++ + P +E +P+ E + + E L +++
Sbjct: 10102 PQEEEVLFEEEIVPEEEVLPEEEEVLPE----------------EEEVLPEEEEVLPEEE 10145
Query: 1426 ESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMS 1485
E P EE ++V P E Y ++E +F P +E + K V A
Sbjct: 10146 EIPPEE--------EEVPPEEE------YVPEEE----EFVPEEEVLPEVKPKVPVPAPV 10187
Query: 1486 SQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKS-ATPVDEGVAEDTYS 1544
+ + E+K+ V P + + K+ V +K P +E V
Sbjct: 10188 PEIKKKVTEKKV--VIPKKEEA-------PPAKVPEVPKKVEEKRIILPKEEEVLP---- 10234
Query: 1545 HMEGVASVSTASVATSSFPE--PTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQ 1602
+E ++ PE P+ ++V EV P EV + +V + PT
Sbjct: 10235 -VEVTEEPEEEPISEEEIPEEPPSIEEVE-----EVAPPRVPEV---IKKAVPEAPTPV- 10284
Query: 1603 ETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSI-EFGQESPEQSLAMD 1661
P K E P P S K + + PV + E + E ++ PE+ + +
Sbjct: 10285 -----PKKVEAP------PAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPEKKVLVP 10333
Query: 1662 FSRQSPDHPTVGAGVL----------HITENGPTEVDYSPSDMQDSSLSHKIPPMEEPSY 1711
P P G VL + E++ +++++ + +EE Y
Sbjct: 10334 KKEAVP--PAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEE--Y 10389
Query: 1712 TQD---NDLSELISVSQ--VEASPSTSSAHTPSQIASPLQEDTL-SDVAPPRDMSLYASL 1765
++ +++ E I + Q VE H ++ + + APP+ +
Sbjct: 10390 FEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEI---- 10445
Query: 1766 TSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSSSPPIDAA 1825
SEK+ + PK + + PR+ P P V+EK PP
Sbjct: 10446 -SEKI-------IPPKKPPTKVVPRKEPPAKVPEVPKKI-VVEEKVRVPEEPRVPPTKVP 10496
Query: 1826 SAEP 1829
P
Sbjct: 10497 EVLP 10500
Score = 95.5 bits (236), Expect = 6e-19
Identities = 250/1183 (21%), Positives = 437/1183 (36%), Gaps = 133/1183 (11%)
Query: 524 QVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPP-KV-E 581
+VP V + K+ + PA P K E K P KV E PP KV E
Sbjct: 10006 EVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKV---EAPPAKVPE 10062
Query: 582 SKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTV-KK 640
+K++ ++ KP K +VP K EP PV + +++ + + E+ V +
Sbjct: 10063 VPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPE 10122
Query: 641 ETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEK-KEPKKE 699
E +V PE+ EE ++EV +E++ P ++EE P +EE E ++ + +EE E K +
Sbjct: 10123 EEEVLPEE--EEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPK 10180
Query: 700 VKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKV 759
V P E+KK+V E+K + K+E+ P ++ ++PK ++ L + ++ ++
Sbjct: 10181 VPVPAPVPEIKKKVT-EKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTE 10239
Query: 760 PKKEESVKKDSVAAGKPKEKGKIKVIKKEG--KAAEAVAAAVGTGATTAAVMAAAGIAAI 817
+EE + ++ + P+E I+ +++ + E + AV T A A +
Sbjct: 10240 EPEEEPISEEEI----PEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKV 10295
Query: 818 GPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKL---------- 867
+K++ E+ P + K E A+ +V K + + L+ +E +
Sbjct: 10296 --SKKIPEEKV----PVPVQKK-EAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLE 10348
Query: 868 -KETEPVEAYVIQKER--------EVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQ 918
K + V+ KER EV + P E + EGE + EE +E+
Sbjct: 10349 EKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEV-EEFIKLEQH 10407
Query: 919 GVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESA 978
V++ + E E + EE E+ + P + E + K PT +
Sbjct: 10408 RVEEEHRVEK----VHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPT--KVVP 10461
Query: 979 KAEADAYIRE-KRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAE--DAREEEYE 1035
+ E A + E ++ V R E+ K +E E K A++ E
Sbjct: 10462 RKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAP 10521
Query: 1036 PEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSE 1095
P K+ + K + + P A + P E +P E
Sbjct: 10522 PPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVP------EAIPPKPE 10575
Query: 1096 SEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESP 1155
S E +E PE+ + + E TP+ P++V+ ++ P
Sbjct: 10576 SPPPEVPEAPKEVVPEKKVPAAPPKKP------EVTPVKVPEAPKEVVPEK--KVPVPPP 10627
Query: 1156 SQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEE 1215
+ V TK P E +A K + PP EE
Sbjct: 10628 KKPEVPPTKVPE-------------VPKVAVPEKKVPEAIPPKPESP------PPEVFEE 10668
Query: 1216 DKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPS--PLEKTPLG 1273
+ AL + +EV ++ + V K+P++ P P++ +
Sbjct: 10669 PE--EVALEEPP-AEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVP 10725
Query: 1274 ERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGH 1333
+ V P + EA A V PEV +EVV E + K + V
Sbjct: 10726 KEVVPEKKVPLVVPKKPEAPPAKV-PEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVL 10784
Query: 1334 TPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEP-VPDSESPIE 1392
P E++ P EV E+P + E A +E + V+ +EP VP P E
Sbjct: 10785 EEKPAVPVPERAESPPPEVYEEPEEIAPEEEI--APEEEKPVPVAEEEEPEVPPPAVPEE 10842
Query: 1393 -KVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTST 1451
K + P + P+I A +K E P K + P +P E
Sbjct: 10843 PKKIIPEKKVPVIKKPEAPPPKEPEPEKV----IEKP---KLKPRPPPPPPAPPKEDVKE 10895
Query: 1452 SLYQDK-----------QEGKSTDFAPIKEDFGQEKKTDDVEAMSSQP----ALALDERK 1496
++Q K Q + + P+K G++K + +P L RK
Sbjct: 10896 KIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRK 10955
Query: 1497 LGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTAS 1556
+ +++ + K K ++ E PV+E + +
Sbjct: 10956 RPEEEEPKVEPKKLEKVK---KPAVPE----PPPPKPVEEVEVPTVTKRERKIPEPTKVP 11008
Query: 1557 VATSSFPEPTTDDVSPSLHAEVGS--PHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECP 1614
+ P P + P AEV + P E + + + V P ++ E KEE
Sbjct: 11009 EIKPAIPLPAPEP-KPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAA 11067
Query: 1615 RPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQS 1657
+P P PK K+ +P++ R + S G++ P+++
Sbjct: 11068 KPK--GPIKGVPK--KTPSPIEAERRKLRPGS--GGEKPPDEA 11104
Score = 79.3 bits (194), Expect = 4e-14
Identities = 210/968 (21%), Positives = 337/968 (34%), Gaps = 189/968 (19%)
Query: 524 QVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESK 583
+VP PV K K+ ++ P K +P K V KE P +E+ V +
Sbjct: 10303 KVPVPVQK----KEAPPAKVPEVP--KKVPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFR 10356
Query: 584 EKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKP-------KAAKEK 636
++V+VK+ ++ E + E E+P +EE V+ E + +V+ + +E
Sbjct: 10357 QEVVVKER--LELEVVEAEVE-EIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEH 10413
Query: 637 TVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEP 696
V+K +V + EE E +K A + +K PKK K +KE + + P
Sbjct: 10414 RVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVP 10473
Query: 697 KKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKL--PKD-AKKSSTPLSEAKKPA 753
KK + EEK V +E + P ++ ++ PK+ + P+ AKKP
Sbjct: 10474 KK--------------IVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPE 10519
Query: 754 ALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAG 813
A PKVP+ + V + P +K ++ K E AAV A+
Sbjct: 10520 APPPKVPEAPKEVVPEKKVPVPPPKKPEV----PPTKVPEVPKAAVPEKKVPEAI----- 10570
Query: 814 IAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPV 873
P K + +P+++ + ++V KP++ ++ E KE P
Sbjct: 10571 -----PPKPESPPPEVPEAPKEVVPE------KKVPAAPPKKPEVTPVKVPEAPKEVVPE 10619
Query: 874 EAYVIQKEREVTKGPAESPD-EGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAG 932
+ + ++ P + P+ + E ++ PE + P + ++
Sbjct: 10620 KKVPVPPPKKPEVPPTKVPEVPKVAVPE-----KKVPEAIPPKPESPPPEV--------- 10665
Query: 933 FEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRES 992
FEE E E AE EEPE V V K P + +A A + +K E
Sbjct: 10666 FEEPEEVALEEPPAEV--VEEPEPAAPPQVTVPPKKPVP-------EKKAPAVVAKKPEL 10716
Query: 993 VASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKA 1052
++ E P+++ E V VV K
Sbjct: 10717 -------------PPVKVPEV----------------------PKEVVPEKKVPLVVPKK 10741
Query: 1053 AEAGGAE-EQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPE 1111
EA A+ + P K++ P + + + E + E E P
Sbjct: 10742 PEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPP 10801
Query: 1112 EFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYS 1171
E E E P +E++ + EE E P
Sbjct: 10802 E----------VYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVP----------- 10840
Query: 1172 QEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDK-FSRSALRDAYCSE 1230
+P + P K +A PP E +K + L+
Sbjct: 10841 ---EEPKKIIPEKKVPVIKKPEA-------------PPPKEPEPEKVIEKPKLKPRPPPP 10884
Query: 1231 VKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPL----GERSVNFSLTPNEI 1286
A D+K+ I + K P K P P +E TPL GE+ V L P E
Sbjct: 10885 PPAPPKEDVKEKIFQL---KAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVR-KLLP-ER 10939
Query: 1287 KVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLE-VVSPSQSVTGSAGHTPYYQSPT---D 1342
K + EV V V ++ EE E K LE V P+ + PT
Sbjct: 10940 KPEPKEEV--VLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKR 10997
Query: 1343 EKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSP- 1401
E+ PT+V E PA+P+ K E E ++ P P+E +P+ +P
Sbjct: 10998 ERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKP---------PPVEPEPTPIAAPV 11048
Query: 1402 --PLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQE 1459
P++G + A+ KA A P K +G P + E L
Sbjct: 11049 TVPVVGKK--------AEAKAPKEEAAKP---KGPIKGVPKKTPSPIEAERRKLRPGSGG 11097
Query: 1460 GKSTDFAP 1467
K D AP
Sbjct: 11098 EKPPDEAP 11105
Score = 78.2 bits (191), Expect = 9e-14
Identities = 201/894 (22%), Positives = 327/894 (36%), Gaps = 157/894 (17%)
Query: 604 EKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKK--ETKVKPEDKKEEKEK----PK 657
+KEV + V A+V EK+A PK K+ ++K +T + E++K + K K
Sbjct: 9153 QKEVYEESHERKVPAKVPEKKAPP-PPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSK 9211
Query: 658 KEVAKKEDKTPIKKEE---KPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVK 714
K V +K +TP+++E K KK V E K ++EV P EV+KE+
Sbjct: 9212 KIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVP--EVQKEIV 9269
Query: 715 KEEKKEVKKEEK-EPKKEIKKLP-KDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVA 772
EEK V ++ EP ++ +LP K A + P+ KK PKVP+ V K V
Sbjct: 9270 TEEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPE----VPKKPV- 9324
Query: 773 AGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSS 832
P+EK + V KKE A V P K + E+
Sbjct: 9325 ---PEEKKPVPVPKKEPAAPPKVPEV--------------------PKKPVPEEKI---- 9357
Query: 833 PEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESP 892
P + K E A+ +V K + + ++ ++ + P + +K+ + P
Sbjct: 9358 PVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRK 9417
Query: 893 DEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAE 952
+E + + P++ P EK V + E S +T E++ EE
Sbjct: 9418 EEEVPPPP---KVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKL 9474
Query: 953 E---PEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIE 1009
P+ V ++H + +EE + +E + + SV ++R EE+ E E
Sbjct: 9475 SFAVPQR-------VEVTRHEVSAEEEWSYSEEEEGVSI---SVYREEEREEEEEAEVTE 9524
Query: 1010 KGEAEQSEEEADEED--------KAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQ 1061
E+ EE EE +AE A E + +K+ + + A +++ A E
Sbjct: 9525 YEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAP 9584
Query: 1062 YGFLTTPTKQLGAQSPGRE--PASSIHDETLPGGSESEATASDEENREDQPEEFTATSGY 1119
+ P K++ A P +E P + +E P E + + ++P T +
Sbjct: 9585 KKIV--PEKKVPAPVPKKEKVPPPKVPEE--PKKPVPEKKVPPKVIKMEEPLPAKVTERH 9640
Query: 1120 TQSTIE-----------------ISSEP------------TPMDEMSTP--------RDV 1142
Q T E + EP P E P R V
Sbjct: 9641 MQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVV 9700
Query: 1143 MSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNA 1202
++ + E + Q +T E + Y+ + + E + + D K++
Sbjct: 9701 KEEKVSIEAPKREPQPIKEVTIMEEK--ERAYTLEEEAVSVQREEEYEEYEEYDYKEFEE 9758
Query: 1203 SAST--ISPPSSMEEDKFSRSALRDAYCSEVKASTTL---------------DIKDSISA 1245
T EE ++ R + Y +E + + K A
Sbjct: 9759 YEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKA 9818
Query: 1246 VSSEKVSPSKSPSLSPSPPS-PLEKTPLGERSVNFSLTPNE-IKVSAEAEVAPVSPE--V 1301
V EKV L P PP P E + E + S+T E +V+ A P+ P+ V
Sbjct: 9819 VPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVV 9878
Query: 1302 TQE---VVEEHCASP--------EDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPT 1350
+E V + A P E + EV + VT H Y +E+ H
Sbjct: 9879 AEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVT----HVEEYLVEEEEEYIHEEE 9934
Query: 1351 EVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVP---DSESPIEKVLSPLRSP 1401
E I + VPV E R V +PVP E+P KV + P
Sbjct: 9935 EFITEEEVVPV---IPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKP 9985
Score = 74.7 bits (182), Expect = 1e-12
Identities = 153/670 (22%), Positives = 252/670 (37%), Gaps = 113/670 (16%)
Query: 490 PGNSTQYNILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTK-----LKQRADSRES 544
P + Y+++ LE + T K++ ++ P + ++ + RA E
Sbjct: 8897 PDDEGVYSVIARLEPRGEARSTAELYLTTKEIKLELKPPDIPDSRVPIPTMPIRAVPPEE 8956
Query: 545 LKPA-AKPLPSKSVRKESKEETP---EVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKP 600
+ P A P+P E K+ P EVTK + KV +K K M +++ +K P
Sbjct: 8957 IPPVVAPPIPLLLPTPEEKKPPPKRIEVTKKAVKKDAKKVVAKPKEMTPREEIVKKPPPP 9016
Query: 601 SVTEK-------EVPSKEEPSPVKAEVAEKQATDVKPKA-AKEKTVKKETKVKPEDKKEE 652
+ +V SK E + +K+ K K++ V KE +V E +E
Sbjct: 9017 TTLIPAKAPEIIDVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEP 9076
Query: 653 KEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKE-------------------EK 693
++ + E + + P +E EE+K E KKE+ +E E
Sbjct: 9077 YDELEVEPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEG 9136
Query: 694 KEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAK--------KSSTP 745
+E +E +E +V+KEV EE E K K P+K+ PK K K+S
Sbjct: 9137 EEEWEEAYQEREVIQVQKEV-YEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRR 9195
Query: 746 LSEAKKPAALKPKVPKK-------EESVKKDSVAAGKPKEKGKIKVIKKE-----GKAAE 793
+ E K P+V KK V+++ + P K VI +E E
Sbjct: 9196 MEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEE 9255
Query: 794 AVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKD 853
V+ V +A +K +E + PE + + V + K
Sbjct: 9256 EVSVTVPEVQKEIVTEEKIHVAI---SKRVEPPPKVPELPEKPAPE----EVAPVPIPKK 9308
Query: 854 IKPQLELIEDEEKL---KETEPV-----EAYVIQKEREVTKGPAESPDEGITTTEGEGEC 905
++P + + K +E +PV E K EV K P P+E I + +
Sbjct: 9309 VEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPV--PEEKIPVPVAKKK- 9365
Query: 906 EQTPEELEPVEKQGVDD------IEKFEDEGAGFEESSETGDYEEKAETEEAEE------ 953
E P ++ V+K V + ++ E E + EE+ EE
Sbjct: 9366 EAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPP 9425
Query: 954 --------PEEDGEEHVCVSASKHSPTEDEESAK---AEADAYIREKRESVASGDDRAEE 1002
P + + V V +K +P E +K E ++ E++ S A R E
Sbjct: 9426 KVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAV-PQRVEV 9484
Query: 1003 DMDEAIEKGEAEQSEEE---------ADEEDKAEDAREEEYEPEKMEAEDYV----MAVV 1049
E + E SEEE +E ++ E+A EYE + E E+YV + ++
Sbjct: 9485 TRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVME-EPEEYVVEEKLHII 9543
Query: 1050 DKAAEAGGAE 1059
K EA AE
Sbjct: 9544 SKRVEAEPAE 9553
Score = 71.2 bits (173), Expect = 1e-11
Identities = 76/275 (27%), Positives = 113/275 (41%), Gaps = 34/275 (12%)
Query: 512 KQPLATQKDLTGQVPTPVVKQTKLKQRADSRESL------KPAAKPLPSKSVRKESKEET 565
++P+ ++ +VP P V + K + + + P +P P K + K +
Sbjct: 10821 EKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPR 10880
Query: 566 PEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEK-EVPSKEEPSPVKAEVAEKQ 624
P PPK + KEK+ K P K V EK +VP K E +P+K EK+
Sbjct: 10881 PPPPP----PAPPKEDVKEKIFQLKAIP-----KKKVPEKPQVPEKVELTPLKVPGGEKK 10931
Query: 625 ATDV----KPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEV 680
+ KP+ +E +K + +PE+++ + E K E KK P E P K
Sbjct: 10932 VRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKK----PAVPEPPPPKPVE 10987
Query: 681 KKEVKKEIKKEEK-KEPKK--EVKKETP-PKEVKKEVKKEEKKEVKKEEKEPKKEIKKLP 736
+ EV K+E K EP K E+K P P K + E K +K EP+ P
Sbjct: 10988 EVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAP 11047
Query: 737 KDA------KKSSTPLSEAKKPAALKPKVPKKEES 765
++ P EA KP VPKK S
Sbjct: 11048 VTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTPS 11082
Score = 51.2 bits (121), Expect = 1e-05
Identities = 62/295 (21%), Positives = 125/295 (42%), Gaps = 38/295 (12%)
Query: 595 KTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKE 654
+T + + T + +E +AE V AKE+ +K TK K+E+
Sbjct: 448 QTAQRTTTTAVHIQPAQEQVRKEAEKTAVTKVVVAADKAKEQELKSRTKEVITTKQEQMH 507
Query: 655 KPKKEVAKKEDKTPIKKE--EKPKKEEVKKEVKKEIKKEEKKEPKKEVKKET-------- 704
+++ K+ +KT + K K +E + + +EI K++K+ ++ +++ET
Sbjct: 508 VTHEQIRKETEKTFVPKVVISAAKAKEQETRISEEITKKQKQVTQEAIRQETEITAASMV 567
Query: 705 ---PPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPK 761
K K E ++E ++ + +K+ K+ +K+ P K PKV K
Sbjct: 568 VVATAKSTKLETVPGAQEETTTQQDQMHLSYEKIMKETRKTVVP-----KVIVATPKV-K 621
Query: 762 KEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAK 821
+++ V + +E+ +I K +A + T +T AV A AK
Sbjct: 622 EQDLVSRGREGITTKREQVQITQEKMRKEAEK-------TALSTIAV-------ATAKAK 667
Query: 822 ELEAERSLMSSPEDLTKDFEELKAE--EVDVTKDIKPQLELIEDEEKLKETEPVE 874
E E +++ + E + E+++ +VDV K + ++ ++ + EP E
Sbjct: 668 EQE---TILRTRETMATRQEQIQVTHGKVDVGKKAEAVATVVAAVDQARVREPRE 719
Score = 48.5 bits (114), Expect = 8e-05
Identities = 158/852 (18%), Positives = 299/852 (35%), Gaps = 123/852 (14%)
Query: 518 QKDLTGQVPTPVVK------------QTKLKQRADSRESLKPAAKPLPSKSVRKESKEET 565
Q +TG +PTPVVK ++ Q D L A P S + +
Sbjct: 124 QVRVTG-IPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSV 182
Query: 566 PEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQA 625
T + V+ +E+V KK K I + + S + + K+ + A
Sbjct: 183 GRATSTAEL----LVQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIATVE 238
Query: 626 TDVKPKAAKEKTVKKETKVKPEDKKEEKEKP----KKEVAKKEDKTPIKKEEKPKKEEVK 681
+ A ++ K ++ P+ K P K ++A+++ +PI+ P + V+
Sbjct: 239 MVIDGAAGQQLPHKTPPRIPPKPKSRSPTPPSIAAKAQLARQQSPSPIRHSPSPVRH-VR 297
Query: 682 KEVKKEIKKEEKKEPKKEVKKETPPKEVKKEV--KKEEKKEVKKEEKEPKKEIKKLPKDA 739
++ P + +P + V+ + +K + V + P K+ A
Sbjct: 298 APTPSPVRSVS---PAARIST-SPIRSVRSPLLMRKTQASTVATGPEVPPPW-KQEGYVA 352
Query: 740 KKSSTPLSEAKKPAALKPKVPKKEES---VKKDSVAAGKPKEKGKIKVIKKEGKAAEAVA 796
S + E + + + ++ E V++ +G + AAEAVA
Sbjct: 353 SSSEAEMRETTLTTSTQIRTEERWEGRYGVQEQVTISGAAGAAASVSA--SASYAAEAVA 410
Query: 797 AAV-------GTGATTAAVMAAAGIAAIGP----AKELEAERS------LMSSPEDLTKD 839
A A V+AA +A + A E A+R+ + + E + K+
Sbjct: 411 TGAKEVKQDADKSAAVATVVAAVDMARVREPVISAVEQTAQRTTTTAVHIQPAQEQVRKE 470
Query: 840 FEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTT 899
E+ +V V D + EL +++ T+ + +V ++ P I+
Sbjct: 471 AEKTAVTKVVVAADKAKEQELKSRTKEVITTKQEQMHVTHEQIRKETEKTFVPKVVISAA 530
Query: 900 EGEGECEQTPEELEPVEKQGVDDIEKFEDE---------GAGFEESSETGDYEEKAETEE 950
+ + + + EE+ +KQ + + E E ET ++ T +
Sbjct: 531 KAKEQETRISEEITKKQKQVTQEAIRQETEITAASMVVVATAKSTKLETVPGAQEETTTQ 590
Query: 951 AEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEK 1010
++ E+ + + P + K + + RE + + ++ + ++ ++
Sbjct: 591 QDQMHLSYEKIMKETRKTVVPKVIVATPKVKEQDLVSRGREGITTKREQVQITQEKMRKE 650
Query: 1011 GEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTK 1070
E A KA++ E M + V + G E +
Sbjct: 651 AEKTALSTIAVATAKAKEQETILRTRETMATRQEQIQVTHGKVDVGKKAEAVATVVAAVD 710
Query: 1071 QLGAQSPGREPA----SSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEI 1126
Q + P REP S TL G + +A+ +P
Sbjct: 711 QARVREP-REPGHLEESYAQQTTLEYGYKERISAAKVAEPPQRP---------------- 753
Query: 1127 SSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGF 1186
+SEP + + PR + ++PS+ + T + S + K D+T
Sbjct: 754 ASEPHVVPKAVKPRVI----------QAPSETHIKTTDQKGMHISSQIKKTTDLTT---- 799
Query: 1187 SEGSKTDATDGKDYNASAS-TISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISA 1245
+ D + AS T+S K S Y + + S ++ +SA
Sbjct: 800 ---ERLVHVDKRPRTASPHFTVS--------KISVPKTEHGYEASIAGSAIATLQKELSA 848
Query: 1246 VSS-EKVSPS-KSPSLSPS------PPSPLEKTPLGERSVNFSLTPNEIKVSAEAEV-AP 1296
SS +K++ S K+P++ PS P+PL + P F+ TP+ K A EV
Sbjct: 849 TSSAQKITKSVKAPTVKPSETRVRAEPTPLPQFP-------FADTPDTYKSEAGVEVKKE 901
Query: 1297 VSPEVTQEVVEE 1308
V +T V E
Sbjct: 902 VGVSITGTTVRE 913
Score = 47.0 bits (110), Expect = 2e-04
Identities = 184/888 (20%), Positives = 341/888 (38%), Gaps = 117/888 (13%)
Query: 576 KPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVK--AEVAEKQATDVKPKAA 633
K + +SKE+ ++ ++ + ++ E+ S E P+ A+ A ++A + A
Sbjct: 31891 KKQEFKSKEE----HERHVQKQIDKTLRMAEILSGTESVPLTQVAKEALREAAVLYKPAV 31946
Query: 634 KEKTVKKETKVKPEDKKEEKE-KPKKEV--AKKEDKTPIKKEEKPKKEEVKKEVK--KEI 688
KTVK E +++ E+KKEE++ + +V +K +T I+++++ K+ ++K K+I
Sbjct: 31947 STKTVKGEFRLEIEEKKEERKLRMPYDVPEPRKYKQTTIEEDQRIKQFVPMSDMKWYKKI 32006
Query: 689 KKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVK-----KEEKEPKKEIKKLPKDAKKSS 743
+ + + K + + PK ++ + + E+ V ++ PK I KL +D
Sbjct: 32007 RDQYEMPGKLDRVVQKRPKRIR--LSRWEQFYVMPLPRITDQYRPKWRIPKLSQDD---- 32060
Query: 744 TPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGA 803
E +PA + P + + + G ++ + I +
Sbjct: 32061 ---LEIVRPARRRTPSPDYDFYYRPRRRSLGDISDEELLLPIDDYLAMKRTEEERLRLEE 32117
Query: 804 TTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIED 863
+A+ + P EL + R SSP+ K EE + + T I + E
Sbjct: 32118 ELELGFSASPPSRSPPHFELSSLR--YSSPQAHVK-VEETRKDFRYSTYHIPTKAEASTS 32174
Query: 864 EEKLKETEPVEAYVIQKEREVTKGPAESPD--EGITTTEGEGECEQTPEELEPVEKQGVD 921
+L+E AY K+R+ E + +TTT+ E + EL+ + K+
Sbjct: 32175 YAELRERHAQAAYRQPKQRQRIMAEREDEELLRPVTTTQHLSEYK---SELDFMSKE--- 32228
Query: 922 DIEKFEDEGAGFEESSETGDYEEKAE-TEEAEEPEEDGEEHVCVSASKHSPTEDEESAKA 980
EK + E +E + EE+ E ++ A+ + SPT E
Sbjct: 32229 --EKSRKKSRRQREVTEITEIEEEYEISKHAQRESSSSASRLLRRRRSLSPTYIE----- 32281
Query: 981 EADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEP---- 1036
+R E + S AEE D+ + + + + +E
Sbjct: 32282 ----LMRPVSELIRSRPQPAEEYEDDTERRSPTPERTRPRSPSPVSSERSLSRFERSARF 32337
Query: 1037 ------EKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSP----GREPASSIH 1086
E M+A ++ E +++ + P L +S G+ ++
Sbjct: 32338 DIFSRYESMKAALKTQKTSERKYEV-LSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILN 32396
Query: 1087 DETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDE 1146
++ P +E + + E +E +T TSG T+EI T D+ T R V +
Sbjct: 32397 VQSKP-TAEVKWYHNGVELQESSKIHYTNTSGVL--TLEILDCHT--DDSGTYRAVCT-- 32449
Query: 1147 TNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDA------TDGKDY 1200
N + E+ +++T + + Y+ + + + P + F E ++T+A +
Sbjct: 32450 --NYKGEASDYATLDVTGGDYTTYASQ--RRDEEVPRSVFPELTRTEAYAVSSFKKTSEM 32505
Query: 1201 NASASTISPPSSMEEDKFSRSALRDAYCSEVKA-----------STTLDIKDSISA---- 1245
AS+S S M E + S S+ + +E+K+ STT IK +++A
Sbjct: 32506 EASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILT 32565
Query: 1246 -VSSEKVSPSKSPSLS---PSPPSP----LEKTPLGERSVNFSLTPNEIKVSAEAEVAPV 1297
S V +S S P P L K + S +T + K + E
Sbjct: 32566 KPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQA 32625
Query: 1298 SPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPP 1357
S E VV E+ ++ + VT A SP KS P ++ P
Sbjct: 32626 SDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKA-----VTSPPRVKS---PEPRVKSPE 32677
Query: 1358 AVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLS-PLRSPPLI 1404
AV + + +A VSP + +P EKV P+ +PP I
Sbjct: 32678 AVKSPKRVKSPEPSHPKA-VSPTE----TKPTPTEKVQHLPVSAPPKI 32720
Score = 46.2 bits (108), Expect = 4e-04
Identities = 91/430 (21%), Positives = 162/430 (37%), Gaps = 56/430 (13%)
Query: 529 VVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMV 588
VV+ ++ KQ A+ +++ A + + K P V V+ P +V+S E
Sbjct: 32634 VVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHP 32693
Query: 589 KKDKPIKTETKPSVTEK--EVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVK- 645
K P TETKP+ TEK +P P + AE K E +V + +V
Sbjct: 32694 KAVSP--TETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTW 32751
Query: 646 PEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVK-KEIKKEEKKEPKKEVKKET 704
+D K+ KE + D T E+K + + ++ E E+ E
Sbjct: 32752 YKDGKKLKENGHFQFHYSADGT--------------YELKINNLTESDQGEYVCEISGEG 32797
Query: 705 PPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPK----VP 760
+ + + K + ++ + + K K + + T +E K P + K
Sbjct: 32798 GTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTG 32857
Query: 761 KKEESVKKDSVA------AGKPK-------------EKGKIKVIKKEGKAAEAV--AAAV 799
++ +V DSVA G+P+ + GK K+ + +G +
Sbjct: 32858 LQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTS 32917
Query: 800 GTGATTAAVMAAAGIAA------IGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKD 853
+G T V +AG + I K+ EA++ ++T + + EE+
Sbjct: 32918 DSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKAL 32977
Query: 854 IKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPD-----EGITTTEGEGECEQT 908
++++ E + + K EA + EV K A S + E IT T E +T
Sbjct: 32978 RSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRT 33037
Query: 909 PEELEPVEKQ 918
E++ Q
Sbjct: 33038 HAEIKAFSTQ 33047
Score = 43.9 bits (102), Expect = 0.002
Identities = 93/416 (22%), Positives = 154/416 (37%), Gaps = 55/416 (13%)
Query: 1243 ISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVA-PVSPEV 1301
I AV E++ P +P + P+P EK P +R +T +K A+ VA P
Sbjct: 8949 IRAVPPEEIPPVVAPPIPLLLPTPEEKKPPPKR---IEVTKKAVKKDAKKVVAKPKEMTP 9005
Query: 1302 TQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPV 1361
+E+V++ P + +P S + T +K EV ++ AV
Sbjct: 9006 REEIVKK--PPPPTTLIPAKAPEIIDVSSKAEEVKIMTITRKK------EVQKEKEAV-- 9055
Query: 1362 SFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKAS 1421
+E A + +R + +EP + E +E P P + YE K
Sbjct: 9056 -YEKKQAVHKEKRVFIESFEEPYDELE--VEPYTEPFEQPYYEEPDEDYEEIKVEAKKEV 9112
Query: 1422 GRGAESPFE--------EKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFG 1473
E FE E+ +G + E + ++ E P K
Sbjct: 9113 HEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVIQVQKEVYEESHERKVPAKV--- 9169
Query: 1474 QEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDK-SAT 1532
EKK + +P + E+ + ++ V++ +S+ V K S T
Sbjct: 9170 PEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKV--------PEVSKKIVPQKPSRT 9221
Query: 1533 PVDEGVAEDTYSHMEGVASVSTASVATSS----FPEPTTDDVSPSLHAEVGSPHSTEVDD 1588
PV E V E V +V T + S F T ++VS ++ EV TE
Sbjct: 9222 PVQEEVIE------VKVPAVHTKKMVISEEKMFFASHTEEEVSVTV-PEVQKEIVTEEKI 9274
Query: 1589 SLSVSV-VQTPTTFQETEMSPSKEE---CPRPMSISPPDFSPKTAK-SRTPVQDHR 1639
+++S V+ P E P+ EE P P + PP +PK + + PV + +
Sbjct: 9275 HVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPP--APKVPEVPKKPVPEEK 9328
Score = 41.2 bits (95), Expect = 0.013
Identities = 63/259 (24%), Positives = 93/259 (35%), Gaps = 35/259 (13%)
Query: 2107 LEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQC--DETPPTSV-SESAPSQTDSDVP 2163
+E F +EE E EKP PP G + + + PPT V P +VP
Sbjct: 10422 IEVFEAEE-VEVFEKPKA-------PPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVP 10473
Query: 2164 PE--TEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVD 2221
+ EE + + + E +P + V K + PPA + +P P+ P+
Sbjct: 10474 KKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAK-KPEAPPPKVPEA---- 10528
Query: 2222 PEALAIEQNLGKALKKDLKEKTKTKKPGTKT----KSSSPVKKSDGKSKPLAASPKPAGL 2277
P+ + E+ K + K + P TK K++ P KK P A PKP
Sbjct: 10529 PKEVVPEK------KVPVPPPKKPEVPPTKVPEVPKAAVPEKKV-----PEAIPPKPESP 10577
Query: 2278 KESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATA 2337
+ + P+KK KP TP VK ++ K K T
Sbjct: 10578 PPEVPEAPKEVVPEKKVPAAPPKKPEVTP-VKVPEAPKEVVPEKKVPVPPPKKPEVPPTK 10636
Query: 2338 GPGTTK-TTKSSAVPPGLP 2355
P K VP +P
Sbjct: 10637 VPEVPKVAVPEKKVPEAIP 10655
Score = 40.8 bits (94), Expect = 0.017
Identities = 73/287 (25%), Positives = 100/287 (34%), Gaps = 74/287 (25%)
Query: 2093 PKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPP----PPGGKQQGRQC------ 2142
PK E P + P E E P E E+P APP PP ++
Sbjct: 10656 PKPESPPPEVFEEPEEVALEEPPAEVVEEP---EPAAPPQVTVPPKKPVPEKKAPAVVAK 10712
Query: 2143 -DETPPTSV----SESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKH 2197
E PP V E P + V P+ E P E E +P K K
Sbjct: 10713 KPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKV-----PEVPKEVVPEKKVAVPKK 10767
Query: 2198 MDPPPA-----------------PVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDL- 2239
+ PPA PV +R+ SP P +PE +A E+ + +K +
Sbjct: 10768 PEVPPAKVPEVPKKPVLEEKPAVPVPERAESP--PPEVYEEPEEIAPEEEIAPEEEKPVP 10825
Query: 2240 -------------------KEKTKTKKPGTKTKSSSPVKKSD-------GKSKPLAASPK 2273
K + K P K + P K+ + K KP P
Sbjct: 10826 VAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPP 10885
Query: 2274 PAGLKES-SDKVSRV-ASPKKK--ESVEKAAKPTTTPEVKAARGEEK 2316
PA KE +K+ ++ A PKKK E + K TP +K GE+K
Sbjct: 10886 PAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTP-LKVPGGEKK 10931
Score = 39.3 bits (90), Expect = 0.048
Identities = 62/269 (23%), Positives = 91/269 (33%), Gaps = 34/269 (12%)
Query: 2094 KTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSES 2153
+ E P + P E EE E EKP+ + P E PP +V E
Sbjct: 10795 RAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEP------------EVPPPAVPEE 10842
Query: 2154 APSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQD------ 2207
+ PE + +A E E E + + + PPPAP ++
Sbjct: 10843 PKK-----IIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKI 10897
Query: 2208 ----RSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDG 2263
P + P+ V PE + + +K +++ +KP K + V KS
Sbjct: 10898 FQLKAIPKKKVPEKPQV-PEKVELTPLKVPGGEKKVRKLLPERKPEPKEEV---VLKSVL 10953
Query: 2264 KSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNA 2323
+ +P PK K K V P + VE+ PT T + K E K A
Sbjct: 10954 RKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKPA 11013
Query: 2324 ANASASKSAKTATAGPGTTKTTKSSAVPP 2352
A + A KT K V P
Sbjct: 11014 IPLPAPEPKPKPEA---EVKTIKPPPVEP 11039
Score = 38.5 bits (88), Expect = 0.083
Identities = 128/606 (21%), Positives = 218/606 (35%), Gaps = 93/606 (15%)
Query: 1237 LDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKV------SA 1290
+ ++ + S E+ P+K P PP + K P+ E+ S E KV
Sbjct: 9150 IQVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEV 9209
Query: 1291 EAEVAPVSPE---VTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHT--------PYYQS 1339
++ P P V +EV+E + K + + S+ A HT P Q
Sbjct: 9210 SKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVI---SEEKMFFASHTEEEVSVTVPEVQK 9266
Query: 1340 P--TDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDS-ESPIEKVLS 1396
T+EK ++ +E PP VP E + E A V P+P E P KV
Sbjct: 9267 EIVTEEKIHVAISKRVEPPPKVP---ELPEKPAPEEVAPV-----PIPKKVEPPAPKVPE 9318
Query: 1397 PLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQD 1456
+ P + E + A + E P K+ P++ PV
Sbjct: 9319 VPKKP--VPEEKKPVPVPKKEPAAPPKVPEVP------KKPVPEEKIPVP-------VAK 9363
Query: 1457 KQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALAL---------DERKLGDVSPTQIDV 1507
K+E +++ E+K V P A+ +ERK V + +V
Sbjct: 9364 KKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERK--PVPRKEEEV 9421
Query: 1508 SQFGSFKEDTKMSISEGTVS-----DKSATPVDEGVAEDTYSHMEGVASVSTASVATSSF 1562
K + E V+ K A P V++ T + + S A
Sbjct: 9422 PPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQR 9481
Query: 1563 PEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSK----EECPRPMS 1618
E T +VS AE +S E ++ +S+SV + +E E ++ EE +
Sbjct: 9482 VEVTRHEVS----AEEEWSYSEE-EEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVV 9536
Query: 1619 ISPPDFSPKTAKSRTPVQDHRSEQSSM---SIEFGQESPEQSLAMDFSRQSPDHPTVGAG 1675
K ++ R E+ + I E P + + ++ V A
Sbjct: 9537 EEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAP 9596
Query: 1676 VLHITENGPTEVDYSP-SDMQDSSLSHKIPPMEEP----------SYTQDNDLSELISVS 1724
V + P +V P + + + K+ MEEP TQ+ + L++V+
Sbjct: 9597 VPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQEEKV--LVAVT 9654
Query: 1725 QVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS---PK 1781
+ EA P A P + + E+ + + P R+ A +T + + ++ EK+S PK
Sbjct: 9655 KKEAPP---KARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPK 9711
Query: 1782 SDISPL 1787
+ P+
Sbjct: 9712 REPQPI 9717
Score = 36.6 bits (83), Expect = 0.31
Identities = 49/230 (21%), Positives = 88/230 (38%), Gaps = 5/230 (2%)
Query: 500 EGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRK 559
EG +L F+ Q + + ++ K + +R++ A +P+ SK V
Sbjct: 32796 EGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIV 32855
Query: 560 ESKEETPEVTKVNHVEKPPKVESKEK---VMVKKDKPIKTETKPSVTEKEVPSKEEPSPV 616
++T V+ + + K + + + K K I K ++E + E
Sbjct: 32856 TGLQDTT-VSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKT 32914
Query: 617 KAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPK 676
+ VK A + K T +D + +K +K K + +EE +
Sbjct: 32915 DTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQ 32974
Query: 677 KEEVKKEVK-KEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEE 725
K +E+K E K +EK K+E K +EVKK +K + EE
Sbjct: 32975 KALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEE 33024
Score = 33.5 bits (75), Expect = 2.7
Identities = 40/160 (25%), Positives = 63/160 (39%), Gaps = 8/160 (5%)
Query: 2150 VSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRS 2209
++E+ P + + T T+ A + + E E +P KT T Q R
Sbjct: 163 IAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEE-VPAKKTKTIVSTAQISESRQTRI 221
Query: 2210 PSPRHPDVSMVDPEALA-IEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPL 2268
+ D ++A +E + A + L KT + P K KS SP S L
Sbjct: 222 EKKIE---AHFDARSIATVEMVIDGAAGQQLPHKTPPRIP-PKPKSRSPTPPSIAAKAQL 277
Query: 2269 AASPKPAGLKESSDKVSRVASPKKK--ESVEKAAKPTTTP 2306
A P+ ++ S V V +P SV AA+ +T+P
Sbjct: 278 ARQQSPSPIRHSPSPVRHVRAPTPSPVRSVSPAARISTSP 317
Score = 33.5 bits (75), Expect = 2.7
Identities = 58/231 (25%), Positives = 76/231 (32%), Gaps = 44/231 (19%)
Query: 2130 PPPPGGKQQGRQCDETPPTSVSES----APSQTDSDVPPETEECPSITADANIDSEDESE 2185
P PP K E PP V E+ P + PP+ E P E
Sbjct: 10511 PVPPAKKP------EAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVP-----EVPKA 10559
Query: 2186 TIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKT 2245
+P K P P + SP P P+ P+ + E+ + A K E T
Sbjct: 10560 AVPEKKV-------PEAIPPKPESPPPEVPEA----PKEVVPEKKVPAAPPKK-PEVTPV 10607
Query: 2246 KKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTT 2305
K P +P + K P+ KP +V +VA P+KK KP +
Sbjct: 10608 KVP------EAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESP 10661
Query: 2306 PEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVPPGLPV 2356
P EE E A + A A P T VPP PV
Sbjct: 10662 PPEVFEEPEEVALEEPPAEVVEEPEPA----APPQVT-------VPPKKPV 10701
Score = 33.1 bits (74), Expect = 3.5
Identities = 51/209 (24%), Positives = 91/209 (43%), Gaps = 41/209 (19%)
Query: 521 LTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKV 580
+T + P V++ K+K RE + SV + + E PE HV +P K+
Sbjct: 1912 VTAENPEGVIEH-KVKLEIQQREDFR---------SVLRRAPEPRPEF----HVHEPGKL 1957
Query: 581 ESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKK 640
+ + + K D+P+ T KEV VK + AE+ + P+ ++E ++
Sbjct: 1958 QFEVQ---KVDRPVDT-----TETKEV--------VKLKRAERITHEKVPEESEE--LRS 1999
Query: 641 ETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEV 700
+ K + E+ E + ++K+D++ + K K E + KE+ +EEKK +E
Sbjct: 2000 KFKRRTEEGYYEAITAVELKSRKKDESYEELLRKTKDELL--HWTKELTEEEKKALAEEG 2057
Query: 701 KKETPPKEVKKEVKKEEKKEVKKEEKEPK 729
K P K +K E+ + PK
Sbjct: 2058 KITIP-------TFKPDKIELSPSMEAPK 2079
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 112 bits (281), Expect = 3e-24
Identities = 147/571 (25%), Positives = 243/571 (42%), Gaps = 83/571 (14%)
Query: 555 KSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPS 614
+ V ++E E +K N +E+ ++E V V + KTE + ++ K E S
Sbjct: 582 EEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTE----ILSDDLTDKAEVS 637
Query: 615 PVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEK 674
KA+ + +A D P+ + T ++ + + EE+EK +K+ + E + P + E
Sbjct: 638 EGKAK-SVGEAED-GPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGE-- 693
Query: 675 PKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKK 734
KE +KE K+ EE+++ ++E + + +E +EE E ++EE + ++E +K
Sbjct: 694 --KELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEK 751
Query: 735 LPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEA 794
+ ++ E ++ +KEE +K AGK +EKG+ + + EG+ E
Sbjct: 752 EGEGKEEGEGEEVEGER---------EKEEGERKKEERAGK-EEKGEEEGDQGEGEEEET 801
Query: 795 VAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI 854
G +E E + + EE K E + ++
Sbjct: 802 E----------------------GRGEEKEEGGEVEGG------EVEEGKGEREEEEEEG 833
Query: 855 KPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEP 914
+ + E E EE+ E E E + E E +G E E EGEGE E+ E E
Sbjct: 834 EGEEEEGEGEEEEGEGEEEEGEG-KGEEEGEEGEGEEEGE-----EGEGEGEEEEGEGEG 887
Query: 915 VEKQGVDDIEKFEDEGAGFEESSETGDYEE---KAETEEAEEPEEDGEEHVCVSASKHSP 971
E++G + E+ E EG G EE G+ EE K E EE EE E +GEE +
Sbjct: 888 -EEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGE-EEGEEGEGEGEEEEGEGEGEDGE 945
Query: 972 TEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDARE 1031
E EE E + E+ E G++ E + +E +GE E+ E E +EE+ E+ E
Sbjct: 946 GEGEE----EEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEE 1001
Query: 1032 EEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLP 1091
E E+ E E G EE+ G + + + G E +E
Sbjct: 1002 EGEGEEEGEGE--------------GEEEEEGEVEGEVEGEEGEGEGEE------EEGEE 1041
Query: 1092 GGSESEATASDEENREDQPEEFTATSGYTQS 1122
G E E EENR ++ EE Y ++
Sbjct: 1042 EGEEREKEGEGEENRRNREEEEEEEGKYQET 1072
Score = 100 bits (248), Expect = 2e-20
Identities = 130/522 (24%), Positives = 222/522 (42%), Gaps = 83/522 (15%)
Query: 581 ESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKK 640
+ +E+ +KDK +P EKE+ KEE E E++ ++
Sbjct: 670 QDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQK--------------ER 715
Query: 641 ETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVK-KEIKKEEKKEPKKE 699
E + E +E +E ++E + E++ ++EE+ K+ E K+E + +E++ E +KE +
Sbjct: 716 EQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGER 775
Query: 700 VKKETPPKEVKKEVK------KEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPA 753
K+E KE K E + +EE+ E + EEKE E++ + K E +
Sbjct: 776 KKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEG 835
Query: 754 ALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAG 813
+ ++EE ++ GK +E+G+ ++EG+ E
Sbjct: 836 EEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGE-------------------- 875
Query: 814 IAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPV 873
G +E E E E E + EE + + + + E E+E + K E
Sbjct: 876 ----GEGEEEEGEGEGEEEGEG------EGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEG 925
Query: 874 EAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKF------E 927
E + E E +G E +GEGE E+ E E E++G + E+ E
Sbjct: 926 EEGEGEGEEEEGEGEGE---------DGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEE 976
Query: 928 DEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIR 987
EG G EE E G+ EE+ EE EE E +GEE E EE + E + +
Sbjct: 977 GEGEGEEEEGE-GEGEEEEGEEEGEE-EGEGEE--------EGEGEGEEEEEGEVEGEVE 1026
Query: 988 EKRESVASGDDRAEEDMDEAIEKGEAEQS----EEEADEEDKAEDAREEEYEPEKMEAED 1043
+ ++ EE+ +E ++GE E++ EEE +EE K ++ EE E E+ + E+
Sbjct: 1027 GEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEE--ENERQDGEE 1084
Query: 1044 YVMAVVDKAAEAGGAEEQYGFLT-TPTKQLGAQSPGREPASS 1084
Y K + G + Y + T T+ G + + P S
Sbjct: 1085 YKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQS 1126
Score = 86.3 bits (212), Expect = 3e-16
Identities = 146/626 (23%), Positives = 239/626 (38%), Gaps = 102/626 (16%)
Query: 544 SLKPAAKPLPSKSVRKESKEET-PEVTKVNHV-EKPPKVESKEKVMVKKDKPIKTE---- 597
SL K L V+K+ K++T E+T+ + E E +E +K+ K K
Sbjct: 507 SLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQG 566
Query: 598 ---TKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKE 654
T+P+ T + +E P + E AE D K +E+ V E E
Sbjct: 567 IFMTQPATTIEAFSDEEVEIPEEKEGAE----DSKGNGIEEQEV------------EANE 610
Query: 655 KPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVK 714
+ K +++KT I ++ K EV + K + + E E + + +E +
Sbjct: 611 ENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGP---EGRGDGTCEEGSSGAE 667
Query: 715 KEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAG 774
+ +E +K EK+ + E ++P + ++ +KEE K+D
Sbjct: 668 HWQDEEREKGEKDKGR----------------GEMERPGEGEKELAEKEEWKKRDGEEQE 711
Query: 775 -KPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSP 833
K +E+G K +E M G G +E E +R
Sbjct: 712 QKEREQGHQKERNQE--------------------MEEGGEEEHGEGEEEEGDREEEEEK 751
Query: 834 EDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPD 893
E K EE + EEV+ ++ + E E K +E E + E E +G E +
Sbjct: 752 EGEGK--EEGEGEEVEGEREKE------EGERKKEERAGKEE---KGEEEGDQGEGEEEE 800
Query: 894 EGITTTEGEGECEQTPEELEPVE-KQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAE 952
TEG GE ++ E+E E ++G + E+ E+EG G EE E E
Sbjct: 801 -----TEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGE------------GE 843
Query: 953 EPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGE 1012
E E +GEE + E E + E E+ E G++ E + +E +GE
Sbjct: 844 EEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGE 903
Query: 1013 AEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQL 1072
E+ E EE++ E EEE E + E E+ + E G EE+ + ++
Sbjct: 904 GEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEW---EGEEE 960
Query: 1073 GAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTP 1132
+ G E +E G E E + E E++ EE G + E E
Sbjct: 961 EGEGEGEEEGEGEGEE---GEGEGEEEEGEGEGEEEEGEEEGEEEG--EGEEEGEGEGEE 1015
Query: 1133 MDEMSTPRDVMSDETNNEETESPSQE 1158
+E +V +E E E +E
Sbjct: 1016 EEEGEVEGEVEGEEGEGEGEEEEGEE 1041
Score = 64.7 bits (156), Expect = 1e-09
Identities = 107/480 (22%), Positives = 195/480 (40%), Gaps = 84/480 (17%)
Query: 558 RKESKEETPEVTKVNH----VEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEP 613
+KE +E E + H E+ + E +EK K++ E + ++E K+E
Sbjct: 720 QKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEE 779
Query: 614 SPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEE 673
K E E++ + + ++ET+ + E+K+E E EV E+ ++EE
Sbjct: 780 RAGKEEKGEEEGDQGEGE-------EEETEGRGEEKEEGGEVEGGEV---EEGKGEREEE 829
Query: 674 KPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEE-KKEVKKEEKEPKKEI 732
+ + E ++E + E ++ E +E + E K E +E + E + EE + E ++EE E + E
Sbjct: 830 EEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGE- 888
Query: 733 KKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAA 792
++ E ++ G+ +E+G+ + ++EG+
Sbjct: 889 ----------------------------EEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGK 920
Query: 793 EAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTK 852
G G G G +E E E E + EE +
Sbjct: 921 GEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGE--------------WEGEEEEGEGEG 966
Query: 853 DIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPE-- 910
+ + + E E E + +E E + E E +G E +EG EGEGE E+ E
Sbjct: 967 EEEGEGEGEEGEGEGEEEEG------EGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGE 1020
Query: 911 ---ELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSAS 967
E+E E +G + E+ E+EG EE + G+ EE E EE EE
Sbjct: 1021 VEGEVEGEEGEGEGEEEEGEEEG---EEREKEGEGEENRRNREEEEEEE----------G 1067
Query: 968 KHSPTEDEESAKAEADAY--IREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDK 1025
K+ T +EE+ + + + Y + + + SV G + + +G ++ + + K
Sbjct: 1068 KYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSK 1127
>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
sapiens]
Length = 1782
Score = 108 bits (271), Expect = 5e-23
Identities = 300/1421 (21%), Positives = 533/1421 (37%), Gaps = 242/1421 (17%)
Query: 478 ANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQPLATQKD-------LTGQVPTPVV 530
++PA K+++ + Q + + G+ + L + L QK L Q V+
Sbjct: 49 SDPATKLLQ-----KNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVI 103
Query: 531 KQTKLKQRADSRESLKPAAKPLPSKS-----VRKESKEETPEV--------TKVNHVEKP 577
T++ QR S + + K + +KS + + +EETPE+ + + + +P
Sbjct: 104 V-TEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQP 162
Query: 578 PKVESKE------------KVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQA 625
+ ++ + K VKKDK K +T +T K K+E K
Sbjct: 163 TESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVK----KDEGEGAAGAGDHKDP 218
Query: 626 TDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVK 685
+ +AA +++ K++ KPE E K+E + E P + + +E K
Sbjct: 219 SLGAGEAASKESEPKQSTEKPE------ETLKREQSHAEISPPAESGQ------AVEECK 266
Query: 686 KEIKKEEKKEPKKEVKKETPP--KEVKKEVKK--------EEKKEVKKEEKEPKKEIKKL 735
+E +++++KEP K + T P E KK KK ++ KE + E +
Sbjct: 267 EEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEK 326
Query: 736 PKDAKKSSTPLSEAKKPAALKPKVPKKEES-VKKDSVAAGKPKEKGKIKVIKKEGKAAEA 794
K+ + E K K+ E++ ++ + +A +P+ + + K E + E
Sbjct: 327 KKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYE--KVELPSEEQ 384
Query: 795 VAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI 854
V+ + G A +A E+ E + ++ E + EV+ T
Sbjct: 385 VSGSQGPSEEKPAPLAT---EVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGS 441
Query: 855 KPQLELIEDEEKLKETEPVEAYVIQKE-----REVTKGPAESPDEGITTTEGEGECEQTP 909
P EL+E + + +E EP + V KE + T+G SPDE + + EG +
Sbjct: 442 VPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEV- 500
Query: 910 EELEPVEKQGVD-----------DIEKFEDE------GAGFEESSE-------TGDYEEK 945
E L E+ V ++K + G G EES E + D +E+
Sbjct: 501 EMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEE 560
Query: 946 AETEEAEEPEEDGEEHVCVS---ASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEE 1002
+ E + E+ EE C+ A E EE A ++ + +KRE V + +
Sbjct: 561 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGE----KKREGVTPW--ASFK 614
Query: 1003 DMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQY 1062
M ++ ++ DE DK + A E E ++ + V++ EE
Sbjct: 615 KMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPK----PEEPK 670
Query: 1063 GFLTTPTKQ-----LGAQSPGREPASSIHDETLPGGSESEATASDE--ENREDQPEEFTA 1115
+ T +G+ SS +E P + +DE +++E + A
Sbjct: 671 RKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILA 730
Query: 1116 TS-----GYTQSTIEISSEPTPMDEMST----PRDVMSDETNNEETESPSQEFVNITKYE 1166
S G S+ E + PT + +ST R V + + + E S++ + + E
Sbjct: 731 GSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVE 790
Query: 1167 SSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDK--------- 1217
S E K + F G + DGK A P + E+D
Sbjct: 791 HSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLS 850
Query: 1218 ----------FSRSALRDAYCSEVKASTTLDIKDSISAV-----------SSEKVSPSKS 1256
++ A + A E KA+T + + S S V + + +S
Sbjct: 851 EYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERS 910
Query: 1257 PS-LSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPED 1315
PS +S S PLE+ E ++ LT ++ AE P P VT+ + E A +
Sbjct: 911 PSWISASVTEPLEQVE-AEAAL---LTEEVLEREVIAEEEP--PTVTEPLPENREARGDT 964
Query: 1316 KTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERA 1375
E ++VT + P E S+ E E AV + +D+ D E A
Sbjct: 965 VVSEAELTPEAVTAAETAGPLGAEEGTEASA--AEETTEMVSAVS---QLTDSPDTTEEA 1019
Query: 1376 S-VSPMDEPVPDSE-----------SPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR 1423
+ V ++ VPD E + EKV + P G E + A+
Sbjct: 1020 TPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAE------ 1073
Query: 1424 GAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIK-------EDFGQEK 1476
AE P E+ + S + + T L D QE K+ F K E F +
Sbjct: 1074 -AERPEEQA--------EASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAP 1124
Query: 1477 K-TDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSD-KSATPV 1534
+ T+ +E SS+ L V ++ + Q + D S+ T S+ +TPV
Sbjct: 1125 QVTESIE--SSELVTTCQAETLAGVKSQEMVMEQ--AIPPD---SVETPTDSETDGSTPV 1177
Query: 1535 DEGVAEDTYS-------HMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTE-- 1585
+ A T H E + T S T + P + P+ + V + E
Sbjct: 1178 ADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQS 1237
Query: 1586 -VDDSLSVS----VVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS 1640
++D+L + V+T + +TE + ++ + P F T + R
Sbjct: 1238 KMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSRE 1297
Query: 1641 EQSSMSI-----EFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQ 1695
+ + +++ E + + +L + +SP P V+ + E TE + P+ +
Sbjct: 1298 KVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQV-EREKTEAE--PTHVN 1354
Query: 1696 DSSLSHK--IPPMEEPSYTQDNDLSELISVSQVEASPSTSS 1734
+ L H+ + EE S L + ++V ++ + SS
Sbjct: 1355 EEKLEHETAVTVSEEVS----KQLLQTVNVPIIDGAKEVSS 1391
Score = 93.2 bits (230), Expect = 3e-18
Identities = 226/1119 (20%), Positives = 430/1119 (38%), Gaps = 194/1119 (17%)
Query: 558 RKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVK 617
+ E E ++ H ++P + + ++ + +K ++ ++ V+ + PS+E+P+P+
Sbjct: 342 KAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEK-VELPSEEQVSGSQGPSEEKPAPLA 400
Query: 618 AEV--------AEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPI 669
EV E+ +V +E+T +++T+V+ E+ + A+ ++ P
Sbjct: 401 TEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPA 460
Query: 670 KKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPK 729
K+ K K+ V E + + P ++V + PP+ V EV+ +E K + P
Sbjct: 461 KELVKLKETCVSGE---DPTQGADLSPDEKVLSK-PPEGVVSEVEMLSSQERMKVQGSPL 516
Query: 730 KE------IKKL--PKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGK 781
K+ +KKL K K E+ + + P +E K +S +A P+E +
Sbjct: 517 KKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGES-SASSPEEPEE 575
Query: 782 IKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFE 841
I ++K G A GAT+ G+ K++ + + P + K+ E
Sbjct: 576 ITCLEK-GLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDE 634
Query: 842 ELKAEEV----------DVTKDIKPQLELIEDEEKLKETEPVEAY-----VIQKEREVTK 886
K + ++ +++K +E + EE ++ + ++ V ++ +
Sbjct: 635 LDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARR 694
Query: 887 GPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDI---EKFEDEGAGFEESSETGDYE 943
G + + G G+ Q +E ++ G D I + D G G + G
Sbjct: 695 GSSSDEEGGPKAMGGD---HQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPT 751
Query: 944 E--------------KAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYI--- 986
E + + EE E+ + S +HS T D E K E+ I
Sbjct: 752 EGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHS-TPDTEPGKEESWVSIKKF 810
Query: 987 ----REKR-----------ESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDARE 1031
R+KR ++ +G + + D+ + E + E E E +A+ + E
Sbjct: 811 IPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAE 870
Query: 1032 E-------EYEPEKMEAEDYVM--AVVDKAAEAGGAEEQ-----YGFLTTPTKQLGAQSP 1077
+ E E E++ ++M AV D A EE+ +T P +Q+ A+
Sbjct: 871 QPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAE-- 928
Query: 1078 GREPASSIHDETLPGGSESEATASDE---------ENREDQPEEFTATSGYTQSTIEISS 1128
A+ + +E L E E A +E ENRE + + + + T + +
Sbjct: 929 ----AALLTEEVL----EREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAE 980
Query: 1129 EPTPMDEMSTPRDVMSDETN------NEETESP--SQEFVNITKYESSLYSQEYSKPADV 1180
P+ ++ET ++ T+SP ++E + + E + E +
Sbjct: 981 TAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQ 1040
Query: 1181 TPLNGFSEGSKTDA----TDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTT 1236
L +E K ++ T G + + P E ++ A S +K T
Sbjct: 1041 EVLQAVAEKVKEESQLPGTGGPE-----DVLQPVQRAEAER----PEEQAEASGLKKETD 1091
Query: 1237 LDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP 1296
+ +K +E + K + + P EK P V S+ +E+ + +AE
Sbjct: 1092 VVLKVDAQEAKTEPFTQGK--VVGQTTPESFEKAP----QVTESIESSELVTTCQAET-- 1143
Query: 1297 VSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSP-TDEKSS----HLPTE 1351
++ +QE+V E P+ V +P+ S T + + +P T +K H E
Sbjct: 1144 LAGVKSQEMVMEQAIPPD----SVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENE 1199
Query: 1352 VI-----------------EKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKV 1394
V E+PPA P SF F + E S M++ + ++ +
Sbjct: 1200 VASGTQSGGTEAEAVPAQKERPPA-PSSFVFQEETKEQ-----SKMEDTLEHTDKEV--- 1250
Query: 1395 LSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLY 1454
S + S E AD A + + PF E G +GS D VS T +
Sbjct: 1251 -----SVETVSILSKTEGTQEADQYADEKTKDVPFFE--GLEGSIDTGITVSREKVTEV- 1302
Query: 1455 QDKQEGKSTDFAPIKEDFGQEKKTDDVEAMS--SQPALALDERKLGDVSPTQIDVSQFGS 1512
+G+ T+ A K+D E ++ S + + ER+ + PT ++ +
Sbjct: 1303 --ALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEK--- 1357
Query: 1513 FKEDTKMSISEGTVSDKSAT---PVDEGVAEDTYSHMEG 1548
+ +T +++SE T P+ +G E S +EG
Sbjct: 1358 LEHETAVTVSEEVSKQLLQTVNVPIIDGAKE--VSSLEG 1394
Score = 84.3 bits (207), Expect = 1e-15
Identities = 307/1496 (20%), Positives = 533/1496 (35%), Gaps = 203/1496 (13%)
Query: 823 LEAERSLMSSPEDLTKDFEELKAEEVDVTKDIK-PQLELIEDEEKLKETEPVEAYVIQK- 880
+E S S+ E+LT+ E +A ++ K K + ++K ++ + V+ ++K
Sbjct: 146 IEQIPSSESNLEELTQPTES-QANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKD 204
Query: 881 EREVTKGPAESPDEGITTTEG---EGECEQTPEELEPVEK--QGVDDIEKFEDEGAGFEE 935
E E G + D + E E E +Q+ E+ E K Q +I + G EE
Sbjct: 205 EGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEE 264
Query: 936 SSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVAS 995
E G EEK E E ++ E + S + A R+ +E
Sbjct: 265 CKEEG--EEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVE 322
Query: 996 GDDRAEEDMDEAI---EKGEAE------QSEEEADEEDKAEDAREE----EYEPEKMEAE 1042
++ +E E + E G+AE + E+A ++ AE A E EYE ++ +E
Sbjct: 323 ASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSE 382
Query: 1043 DYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASD 1102
+ V + G +EE+ L T + E + +H T+ +E + T +
Sbjct: 383 EQV------SGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVE 436
Query: 1103 EENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNI 1162
E TA S + +E+ +EP +E E P++E V +
Sbjct: 437 E----------TAGSVPAEELVEMDAEP-------------------QEAE-PAKELVKL 466
Query: 1163 TKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSA 1222
E+ + ++ ++ AD++P + K S + SS E K S
Sbjct: 467 K--ETCVSGEDPTQGADLSP---------DEKVLSKPPEGVVSEVEMLSSQERMKVQGSP 515
Query: 1223 LRDAYCSE-VKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSL 1281
L+ + S +K + K E ++ P+ SP ++ GE S +
Sbjct: 516 LKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDS----QEEQKGESSASSPE 571
Query: 1282 TPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPT 1341
P EI E +A V + EE S +K E V+P S + P+
Sbjct: 572 EPEEI-TCLEKGLAEVQQDGE---AEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPS 627
Query: 1342 DEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSP 1401
+ + ++K + +S S A + E S ++EP P E P KV + +
Sbjct: 628 ESDKE----DELDKVKSATLSSTESTASEMQEEMKGS-VEEPKP--EEPKRKVDTSVSWE 680
Query: 1402 PLI--GSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQE 1459
LI GS S+ D+ G A +K+ + G D+ + + + S D +
Sbjct: 681 ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGK-DKETGTDGILAGSQEHDPGQ 739
Query: 1460 GKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKE---- 1515
G S+ E G + + V S L +K + + S GS E
Sbjct: 740 GSSSP-----EQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTP 794
Query: 1516 DTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLH 1575
DT+ E VS K P G + + A V A ++ + V P
Sbjct: 795 DTEPGKEESWVSIKKFIP---GRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL-- 849
Query: 1576 AEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPV 1635
+E + +++ + + P TE+S E M + + A T +
Sbjct: 850 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAA---TII 906
Query: 1636 QDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQ 1695
++ S S+ E E A+ +TE EV ++
Sbjct: 907 EERSPSWISASVTEPLEQVEAEAAL------------------LTE----EV------LE 938
Query: 1696 DSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAP 1755
++ + PP ++ + VS+ E +P A T ++ A PL + ++ +
Sbjct: 939 REVIAEEEPPTVTEPLPENREARGDTVVSEAELTPE---AVTAAETAGPLGAEEGTEASA 995
Query: 1756 PRDMSLYASLTSEKVQSLEG-EKLSPKSDISPLTP--RESSPLYSPTFSDSTSAVKEKTA 1812
+ + S S+ S + E+ +P ++ P E VKE++
Sbjct: 996 AEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQ 1055
Query: 1813 TCHSSSSP----PIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGKTPGDF 1868
+ P+ A AE +A + + L D E + GK G
Sbjct: 1056 LPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQT 1115
Query: 1869 SYAYQKPEETTRSPD-EEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYS---YE 1924
+ PE ++P E + T + + G +++ P DS + E
Sbjct: 1116 T-----PESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1170
Query: 1925 TIGKTTKTPEDG------DYSYEIIEKT---TRTPEEGGYSYDISEKTTSPPEVSGYSYE 1975
T G T D D EI E+ + T G + + + PP S + ++
Sbjct: 1171 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1230
Query: 1976 KTERSRRLLDDISNGYDDSEDGGHTLGDPS----------YSYETTEKITSFPESEGYSY 2025
+ + + ++D + D E T+ S Y+ E T+ + F EG S
Sbjct: 1231 EETKEQSKMEDTLE-HTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEG-SI 1288
Query: 2026 ETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLV 2085
+T +R T E A K T +A + +L A K PS +++ +
Sbjct: 1289 DTGITVSREKVT-----EVALKGEGTEEAECKKDDALELQSHA-KSPPSPVEREMVV--- 1339
Query: 2086 SSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDET 2145
+ + KTE P+ +N LE + +EE K L Q+ P G K+
Sbjct: 1340 ---QVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSP 1396
Query: 2146 PPTSVSESA--------PSQTDSDVPPETEECPSITADANI-----DSEDESETIPTDKT 2192
PP E A S+ + EE + ANI E + ++
Sbjct: 1397 PPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEK 1456
Query: 2193 VTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLK-EKTKTKK 2247
+ K+ D P +D P+ PD + + K L DL+ EKT + K
Sbjct: 1457 SSEKNEDFAAHPGEDAVPT--GPDCQAKSTPVI-VSATTKKGLSSDLEGEKTTSLK 1509
Score = 51.2 bits (121), Expect = 1e-05
Identities = 120/558 (21%), Positives = 214/558 (38%), Gaps = 92/558 (16%)
Query: 526 PTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVE---- 581
P+ V Q + K+++ ++L+ K + ++V SK E + EK V
Sbjct: 1224 PSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEG 1283
Query: 582 -----------SKEKVMVKKDKPIKTET----KPSVTEKEVPSKEEPSPVKAEVA---EK 623
S+EKV K TE K E + +K PSPV+ E+ E+
Sbjct: 1284 LEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVER 1343
Query: 624 QATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPK---------KEVAKKEDKTP--IKKE 672
+ T+ +P E+ ++ ET V ++ ++ KEV+ E P + +E
Sbjct: 1344 EKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQE 1403
Query: 673 E----KPKKEEVKKEVKKEIKKEEKK---EPKKEVKKETPPKEVKKEVKKEEKKEVKKEE 725
E K + + + EE+K E ++ + + EEK K E+
Sbjct: 1404 EAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNED 1463
Query: 726 --KEPKKEIKKLPKDAKKSSTPLS-------------EAKKPAALKPKVPKKEESVK--- 767
P ++ D + STP+ E +K +LK K + +E V
Sbjct: 1464 FAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQE 1523
Query: 768 -KDSVAAGKPK-EKGKIKVIKKEGKAAE-----AVAAAVGTGAT----------TAAVMA 810
K SVA + E G +++ K K + AV V T T T A +
Sbjct: 1524 VKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVI 1583
Query: 811 AAGIAAIGPAKELEAERSLMSSPED--LTKDFEELKAEEV-----DVTKDIKPQLE---L 860
A G E E E S+ ++ +T EE ++ V D++KD+ E
Sbjct: 1584 KADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMT 1643
Query: 861 IEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEE--LEPVEKQ 918
+E E + +E V+ E E +S E +G + E+ +EP E +
Sbjct: 1644 VEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPED----DGHALLAERIEKSLVEPKEDE 1699
Query: 919 GVDDIEKFEDEGAGFEESSETGDY-EEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEES 977
DD++ E++ + ++ +G +E +T ++ E++ + V + K D+
Sbjct: 1700 KGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAI 1759
Query: 978 AKAEADAYIREKRESVAS 995
+ +++RES S
Sbjct: 1760 TPQAQEELQKQERESAKS 1777
Score = 35.8 bits (81), Expect = 0.54
Identities = 102/451 (22%), Positives = 165/451 (36%), Gaps = 90/451 (19%)
Query: 1944 EKTTRTPEEGGYSYDISEKTTSPPEVSGYSYE--KTERSRRLLDDISNGYDD------SE 1995
+++T PEE + S SPP SG + E K E + + S + SE
Sbjct: 233 KQSTEKPEET-LKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSE 291
Query: 1996 DGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYE------TAEKIT 2049
G + + K TSF + + E S K E +EK+T
Sbjct: 292 TGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLT 351
Query: 2050 RTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEW 2109
+ QA + P+E+ + L S EY+ K EL P+ +
Sbjct: 352 ASEQA--------------HPQEPAESAHEPRL----SAEYE--KVEL------PSEEQV 385
Query: 2110 FASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEEC 2169
S+ P+EE PL A K + Q + VS + +T+ E
Sbjct: 386 SGSQGPSEEKPAPL-----ATEVFDEKIEVHQEEVVAEVHVS-TVEERTEEQKTEVEETA 439
Query: 2170 PSITADANIDSEDE-SETIPTDKTVTYKHM---DPPPAPVQDRSPSPR----HPDVSMVD 2221
S+ A+ ++ + E E P + V K P D SP + P+ + +
Sbjct: 440 GSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSE 499
Query: 2222 PEALAIEQNL------------GKALKKDLKEKTKTKKPG--------TKTKSSSPVKKS 2261
E L+ ++ + LKK +K K K+ G T+ + SP +
Sbjct: 500 VEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQE 559
Query: 2262 DGKSKPLAASPKPA--------GLKE-----SSDKVSRVASPKKKESVEKAA--KPTTTP 2306
+ K + A+SP+ GL E +++ + KK+E V A K TP
Sbjct: 560 EQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTP 619
Query: 2307 EVKAARGEEKDKETKNAANASASKSAKTATA 2337
+ + R E DKE + SA+ S+ +TA
Sbjct: 620 KKRVRRPSESDKEDELDKVKSATLSSTESTA 650
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 108 bits (270), Expect = 7e-23
Identities = 146/614 (23%), Positives = 249/614 (40%), Gaps = 119/614 (19%)
Query: 509 DFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKE--ETP 566
DF K P K G+ K ++ D+ + +K ++ S ES E ++
Sbjct: 142 DFNKLP----KKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSR 197
Query: 567 EVTKVNHVEKP-PKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQA 625
+ K N KP P +ES + D K +T V +K+ KE + E K
Sbjct: 198 KGQKKNQKNKPGPNIESGNE---DDDASFKIKT---VAQKKAEKKERERKKRDEEKAK-L 250
Query: 626 TDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEV---------AKKEDKTPIKKEEKPK 676
+K K E K ++K K +K E+E K +V ++++ +TP E+ +
Sbjct: 251 RKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNE 310
Query: 677 KEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVK------KEEKKEVKKEEKEPKK 730
++ KK+ KK KK EK+E +KE KK+ P K K ++ KEE++ K+EE+E K
Sbjct: 311 GDKKKKDKKK--KKGEKEEKEKE-KKKGPSKATVKAMQEALAKLKEEEERQKREEEERIK 367
Query: 731 EIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGK 790
+++L EAK+ K+EE ++++ K KEK + + +KKEGK
Sbjct: 368 RLEEL------------EAKR---------KEEERLEQEKRERKKQKEKERKERLKKEGK 406
Query: 791 A-AEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVD 849
++ A T ++ A G+ P+K+ + + +D + K +
Sbjct: 407 LLTKSQREARARAEATLKLLQAQGVEV--PSKDS------LPKKRPIYEDKKRKKIPQQL 458
Query: 850 VTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTP 909
+K++ +EL E +++ P E+E T P E P
Sbjct: 459 ESKEVSESMELCAAVEVMEQGVP--------EKEETPPPVE------------------P 492
Query: 910 EELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKH 969
EE E E G+DD E + + E K EE EE EE+ EE +
Sbjct: 493 EEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEE 552
Query: 970 SPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDA 1029
E E S E D + ++++S + D + ++M E S+++ +E++A D
Sbjct: 553 EEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSE----YDSDDDRTKEERAYDK 608
Query: 1030 REEEYEPEKMEAEDYV--------------------MAVVDKA-------AEAGGAEEQY 1062
+ E ++E V ++DK EAGG +Q
Sbjct: 609 AKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQI 668
Query: 1063 GFLTTPTKQLGAQS 1076
G P + + Q+
Sbjct: 669 GATNVPLEAINEQT 682
Score = 86.3 bits (212), Expect = 3e-16
Identities = 134/594 (22%), Positives = 234/594 (39%), Gaps = 83/594 (13%)
Query: 543 ESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSV 602
E A + P KS K+ KE+ + + + K + S E +K D+
Sbjct: 27 EGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTEN 86
Query: 603 TEKEVPSKEEPSPVKAEVAEKQA---TDVKPKAAKEKTVKKETKVKPE-----DKKEEKE 654
E+E SK++ K + +KQ+ D + K+ KK K K E D ++
Sbjct: 87 NEEEFTSKDKKK--KGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFN 144
Query: 655 KPKKEVAKKEDKTPIKKEEKPKKEEVKKEVK----------------------KEIKKEE 692
K K+ K K+ K + + E+ K++K K KK +
Sbjct: 145 KLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQ 204
Query: 693 KKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKK------EIKKLP-----KDAKK 741
K +P ++ + ++K +K+ +K+E+E KK +++KL + KK
Sbjct: 205 KNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKK 264
Query: 742 SSTPLSEAKK---PAALKPKV-------PKKEESVKKDSVA----AGKPKEKGKIKVIKK 787
+ E+++ +K KV P EE + + A G K+K K K KK
Sbjct: 265 DQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKK--KK 322
Query: 788 EGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEE 847
K + G T M A AK E E E+ K EEL+A+
Sbjct: 323 GEKEEKEKEKKKGPSKATVKAMQEA------LAKLKEEEERQKREEEERIKRLEELEAKR 376
Query: 848 VDVTKDIKPQLELIEDEEK-LKETEPVEAYVIQKEREVTKGPAES-----PDEGITTTEG 901
+ + + + E + +EK KE E ++ K + + AE+ +G+
Sbjct: 377 KEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSK 436
Query: 902 EGECEQTPEELEPVEKQGVDDIEKFE----DEGAGFEESSETGDYEEKAETEEAEEPEED 957
+ ++ P + K+ +E E E E E G EK ET EPEE+
Sbjct: 437 DSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQG-VPEKEETPPPVEPEEE 495
Query: 958 GEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSE 1017
+ + DEE+ K E + E +E+ EE+ +E E+ E E+SE
Sbjct: 496 EDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKEN-------PEEEEEEEEEEEEDEESE 548
Query: 1018 EEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQ 1071
EE +EE ++E + +E + + + +D + K ++ ++ +Y TK+
Sbjct: 549 EEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKE 602
Score = 79.0 bits (193), Expect = 6e-14
Identities = 133/636 (20%), Positives = 256/636 (40%), Gaps = 70/636 (11%)
Query: 559 KESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKA 618
K+ K ++ + TK + E + K+ +P K++ K +K+ E+ +
Sbjct: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
Query: 619 EVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEK--EKPKKEVAKKEDKTPI----KKE 672
E +A +K A +TV VKP + EE+ K KK+ +K K +E
Sbjct: 63 EELSLEAQGIK---ADRETVA----VKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEE 115
Query: 673 EKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEI 732
+ K + KK K +++ + + K PK+ K + +K KK EE E
Sbjct: 116 LEDKDSKSKKTAKPKVEMYSGSDDDDDFNK--LPKKAKGKAQKSNKKWDGSEEDEDNS-- 171
Query: 733 KKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKK--DSVAAGKPKEKGKIKVIKKEGK 790
KK+ + ++ +S+ S + L+ + +K+ K ++ +G + K+ K
Sbjct: 172 KKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQK 231
Query: 791 AAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDV 850
AE K+ + E++ + K+ EEL+ + D
Sbjct: 232 KAEKKER---------------------ERKKRDEEKAKLRK----LKEKEELETGKKDQ 266
Query: 851 TKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPE 910
+K + Q + E+ K K T +E+ T AE +EG + + + + E
Sbjct: 267 SKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKE 326
Query: 911 ELEPVEKQGVD--DIEKFEDEGAGFEESSETGDYEE-----KAETEEAEEPEEDGEEHVC 963
E E +K+G ++ ++ A +E E EE + E EA+ EE+ E
Sbjct: 327 EKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEK 386
Query: 964 VSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEE 1023
K E +E K E + +RE+ A RAE + +G S++ ++
Sbjct: 387 RERKKQKEKERKERLKKEGKLLTKSQREARA----RAEATLKLLQAQGVEVPSKDSLPKK 442
Query: 1024 DKAEDAREEEYEPEKMEAEDY-----VMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPG 1078
+ ++ + P+++E+++ + A V+ + +E+ P ++ + G
Sbjct: 443 RPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAG 502
Query: 1079 REP----ASSIHDETLPGGS-ESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM 1133
+ AS E + G E + EE E++ EE + E SE +
Sbjct: 503 LDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEG 562
Query: 1134 DEMSTPRDVMSDETNNEET--ESPSQEFVNITKYES 1167
DE + +SDE ++ +T + PS+E + ++Y+S
Sbjct: 563 DEED---EKVSDEKDSGKTLDKKPSKEMSSDSEYDS 595
Score = 38.9 bits (89), Expect = 0.063
Identities = 41/152 (26%), Positives = 57/152 (37%), Gaps = 17/152 (11%)
Query: 2238 DLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVE 2297
D K+K K KK G K + KK K+ A A LKE ++ R + K E
Sbjct: 312 DKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEE 371
Query: 2298 KAAK---PTTTPEVKAARGEEKDKETKNAANASA---SKSAKTATAGPGTT--------- 2342
AK + K R ++K+KE K +KS + A A T
Sbjct: 372 LEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGV 431
Query: 2343 KTTKSSAVPPGLPVYLD--LCYIPNHSNSKNV 2372
+ ++P P+Y D IP SK V
Sbjct: 432 EVPSKDSLPKKRPIYEDKKRKKIPQQLESKEV 463
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 105 bits (263), Expect = 4e-22
Identities = 200/1088 (18%), Positives = 376/1088 (34%), Gaps = 72/1088 (6%)
Query: 880 KEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSET 939
KE EVT G E D G+ ++G E+ EDEG+G +E E
Sbjct: 225 KEAEVTPGTGE--DAGLDNSDGSPSGNGADED---------------EDEGSGDDEDEEA 267
Query: 940 GDYEEKAETEEAEEPEEDGEEHVCVS-------ASKHSPTEDEESAKAEADAYIREKRES 992
G+ ++ + + +E ++ G+E S + ++ E +E E D K E
Sbjct: 268 GNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEE 327
Query: 993 VASG--DDRAEEDMDEAIEKGEAEQ--------SEEEADEEDKAEDAREEEYEPEKMEAE 1042
++G +D + +++ + E E E K++D E P
Sbjct: 328 NSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPS--SGN 385
Query: 1043 DYVMAVVDKAAEAGGAEEQYGFL------TTPTKQLGAQSPGR--EPASSIHDETLPGGS 1094
+ V K E + Q+G + T + + + PG+ EP + + S
Sbjct: 386 RNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDS 445
Query: 1095 ESEATAS----DEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNE 1150
S+ S D+ + D P ++G + E + + + S D D N
Sbjct: 446 NSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGS 505
Query: 1151 ETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPP 1210
+++ + +S S + ++ NG + K+D+ GK ++ + +
Sbjct: 506 DSKGAEDD-------DSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSS 558
Query: 1211 SSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKT 1270
+S + S S D+ S S+ D DS + SS+ + S S S S S +
Sbjct: 559 NSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDS----S 614
Query: 1271 PLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGS 1330
+ S + S + S++++ S + ++ S + S S + S
Sbjct: 615 DSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDS 674
Query: 1331 AGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESP 1390
+ + S SS + SD+ D ++ ++ + D +S
Sbjct: 675 SDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDS 734
Query: 1391 IEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTS 1450
+ S S S S+ S S +S S + S S D + S
Sbjct: 735 SDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDS 794
Query: 1451 TSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQF 1510
+ S+D + + + + SS + + + D S +
Sbjct: 795 SDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSD 854
Query: 1511 GSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDV 1570
S + D+ S SD S + ++ S +S S+ S + S + D
Sbjct: 855 SSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDS 914
Query: 1571 SPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAK 1630
S S ++ S S D+S S + + ++ S S + S + D S +
Sbjct: 915 SDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSS 974
Query: 1631 SRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYS 1690
+ + S +S + S + D S S + + + + D S
Sbjct: 975 DSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 1034
Query: 1691 -PSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDT 1749
SD DSS S + S + D+ S S S + S SS + S +S +
Sbjct: 1035 DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSS 1094
Query: 1750 LSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPTFSDSTSAVKE 1809
S + S +S +S+ S + S SD S + S S + SDS+ +
Sbjct: 1095 DSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS-SDSSESSDS 1153
Query: 1810 KTATCHSSSSPPIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGKTPGDFS 1869
++ S SS D++ + ++ + + + D S DS + S
Sbjct: 1154 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1213
Query: 1870 YAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGKT 1929
+++ S D D + S + S + + SDS S ++ T
Sbjct: 1214 SDSSDSSDSSDSSDSSDSNESSDSSDSSDSS-----------DSSNSSDSSDSSDSSDST 1262
Query: 1930 TKTPEDGD 1937
+ + ++ D
Sbjct: 1263 SDSNDESD 1270
Score = 94.4 bits (233), Expect = 1e-18
Identities = 216/1135 (19%), Positives = 421/1135 (37%), Gaps = 77/1135 (6%)
Query: 1073 GAQSPGREPASSIHDETLPGGSESEATASDE----ENREDQPEEFTATSGYTQSTIEISS 1128
G Q G ++ DE + +E S+ ++ + +E T G + +S
Sbjct: 183 GPQVAGSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTGEDAGLDNS 242
Query: 1129 EPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSE 1188
+ +P + D DE + ++ + + + + Q++ K D +
Sbjct: 243 DGSPSGNGA---DEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDD-------HD 292
Query: 1189 GSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSS 1248
S +D K+Y P + ++ DK S+S A E S ++ ++ S
Sbjct: 293 SSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRES 352
Query: 1249 EKVS-----PSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAE--------VA 1295
++V S++ ++ S +E G S N ++T K + E +
Sbjct: 353 KRVENRITKESETHAVGKSQDKGIEIK--GPSSGNRNITKEVGKGNEGKEDKGQHGMILG 410
Query: 1296 PVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQS-PTDEKSSHLPTEVIE 1354
+ + EVV + P K+ S TGS ++ Y S D+KS +
Sbjct: 411 KGNVKTQGEVV--NIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQG-----D 463
Query: 1355 KPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFL 1414
P + S DA E++ S S D ES S + S+S ++
Sbjct: 464 DPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNN 523
Query: 1415 SADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKE-DFG 1473
S + G + + SGK S S S+ +++S D + S+D + D
Sbjct: 524 SDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSS 583
Query: 1474 QEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATP 1533
+D ++ SS + + D D S + D S K D+ S S+ + SD +
Sbjct: 584 DSDSSDSSDSDSSDSSNSSDSSDSSDSSDSS-DSSDSSDSKSDSSKSESDSSDSDSKSDS 642
Query: 1534 VDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVS 1593
D + D+ + + S ++++ + SS ++D S S S S++ DS + S
Sbjct: 643 SDSN-SSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSS--DSSNSSDSSDSSDSSNSS 699
Query: 1594 VVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQES 1653
+ +++ S S + S S S ++ S S SS S + +S
Sbjct: 700 ESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSD-SSDS 758
Query: 1654 PEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQ 1713
+ S + D S S + + + +++ + SD +SS S + S +
Sbjct: 759 SDSSNSSDSSDSSDSSDSSDSS--NSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSS 816
Query: 1714 DNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSL 1773
D+D S S S + S SS + S +S + + SD + D +S +S+ S
Sbjct: 817 DSDSSN-SSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSD----SSNSSDSSDSS 871
Query: 1774 EGEKLSPKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSSSPPIDAASAEPYGFR 1833
+ S SD S S+ +S + + + +SS S D++++
Sbjct: 872 DSSNSSDSSDSSD--------------SNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDS 917
Query: 1834 ASVLFDTMQHHLALNRDLSTPGLEKDSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYE 1893
++ + + + N + S DS + S +++ S D D +
Sbjct: 918 SNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSS 977
Query: 1894 KTTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEG 1953
++ +SD + SDS S ++ ++ + + D S + +
Sbjct: 978 DSSNSSD---------SSDSSDSSDSSDSSDS-SNSSDSSDSSDSSDSSNSSDSSNSSDS 1027
Query: 1954 GYSYDISEKT-TSPPEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTE 2012
S D S+ + +S S S + ++ S S+ DS D + D S S E+++
Sbjct: 1028 SNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDS-SDSSDSSESSD 1086
Query: 2013 KITSFPESEGYSYETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKS 2072
S S+ S+ ++ + D+S + + S+ S ++SD +++
Sbjct: 1087 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSD 1146
Query: 2073 PSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESE-KPLTQSGGAPP 2131
SE+ D S ++ S S + N + S + ++ S+ + S +
Sbjct: 1147 SSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1206
Query: 2132 PPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESET 2186
D + + S+S+ S SD ++ S + + DS D S++
Sbjct: 1207 SSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDS 1261
Score = 53.1 bits (126), Expect = 3e-06
Identities = 82/494 (16%), Positives = 178/494 (36%), Gaps = 39/494 (7%)
Query: 1857 EKDSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSP 1916
E D+ + GD SY + ++ D + + + + T+ T++
Sbjct: 480 ESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDK 539
Query: 1917 SDSGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSYDISEKTTSPPEVSGYSYEK 1976
SDSG GK+ + D S + + + + S S+ +S + S S
Sbjct: 540 SDSGK-----GKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSD 594
Query: 1977 TERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPD 2036
+ D SN D S+ + D S S ++++ + +SE S ++ +K+ +
Sbjct: 595 SS-------DSSNSSDSSDSSDSS--DSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDS 645
Query: 2037 TSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTE 2096
S+ + ++ + S+ S ++SD +++ S S++ D S ++
Sbjct: 646 NSSDSSDNSD--SSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSD 703
Query: 2097 LSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPS 2156
S S + + +S + +S+ + S + D + + S+S+ S
Sbjct: 704 SSDSSDSDSSDSSDSSNSNSSDSDS--SNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDS 761
Query: 2157 QTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPD 2216
SD ++ S + + DS D S + D S S D
Sbjct: 762 SNSSDSSDSSDSSDSSDSSNSSDSNDSSNS-------------------SDSSDSSNSSD 802
Query: 2217 VS-MVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPA 2275
S D + + + D + + + SS SDG + +
Sbjct: 803 SSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSS 862
Query: 2276 GLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKD-KETKNAANASASKSAKT 2334
+SSD S +S + ++ ++ + D ++ N++++S S ++
Sbjct: 863 NSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSD 922
Query: 2335 ATAGPGTTKTTKSS 2348
++ ++ + SS
Sbjct: 923 SSESSNSSDNSNSS 936
>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
sapiens]
Length = 1684
Score = 105 bits (263), Expect = 4e-22
Identities = 287/1355 (21%), Positives = 506/1355 (37%), Gaps = 229/1355 (16%)
Query: 537 QRADSRESLKPAAKPLPSKS-----VRKESKEETPEV--------TKVNHVEKPPKVESK 583
QR S + + K + +KS + + +EETPE+ + + + +P + ++
Sbjct: 11 QRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQAN 70
Query: 584 E------------KVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPK 631
+ K VKKDK K +T +T K K+E K + +
Sbjct: 71 DIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVK----KDEGEGAAGAGDHKDPSLGAGE 126
Query: 632 AAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKE 691
AA +++ K++ KPE E K+E + E P + + +E K+E +++
Sbjct: 127 AASKESEPKQSTEKPE------ETLKREQSHAEISPPAESGQ------AVEECKEEGEEK 174
Query: 692 EKKEPKKEVKKETPP--KEVKKEVKK--------EEKKEVKKEEKEPKKEIKKLPKDAKK 741
++KEP K + T P E KK KK ++ KE + E + K+ +
Sbjct: 175 QEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEP 234
Query: 742 SSTPLSEAKKPAALKPKVPKKEES-VKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVG 800
E K K+ E++ ++ + +A +P+ + + K E + E V+ + G
Sbjct: 235 EKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYE--KVELPSEEQVSGSQG 292
Query: 801 TGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLEL 860
A +A E+ E + ++ E + EV+ T P EL
Sbjct: 293 PSEEKPAPLAT---EVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEEL 349
Query: 861 IEDEEKLKETEPVEAYVIQKE-----REVTKGPAESPDEGITTTEGEGECEQTPEELEPV 915
+E + + +E EP + V KE + T+G SPDE + + EG + E L
Sbjct: 350 VEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEV-EMLSSQ 408
Query: 916 EKQGVD-----------DIEKFEDE------GAGFEESSE-------TGDYEEKAETEEA 951
E+ V ++K + G G EES E + D +E+ + E +
Sbjct: 409 ERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESS 468
Query: 952 EEPEEDGEEHVCVS---ASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAI 1008
E+ EE C+ A E EE A ++ + +KRE V + + M
Sbjct: 469 ASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGE----KKREGVTPW--ASFKKMVTPK 522
Query: 1009 EKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTP 1068
++ ++ DE DK + A E E ++ + V++ EE + T
Sbjct: 523 KRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPK----PEEPKRKVDTS 578
Query: 1069 TKQ-----LGAQSPGREPASSIHDETLPGGSESEATASDE--ENREDQPEEFTATS---- 1117
+G+ SS +E P + +DE +++E + A S
Sbjct: 579 VSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHD 638
Query: 1118 -GYTQSTIEISSEPTPMDEMST----PRDVMSDETNNEETESPSQEFVNITKYESSLYSQ 1172
G S+ E + PT + +ST R V + + + E S++ + + E S
Sbjct: 639 PGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDT 698
Query: 1173 EYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDK--------------- 1217
E K + F G + DGK A P + E+D
Sbjct: 699 EPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVE 758
Query: 1218 ----FSRSALRDAYCSEVKASTTLDIKDSISAV-----------SSEKVSPSKSPS-LSP 1261
++ A + A E KA+T + + S S V + + +SPS +S
Sbjct: 759 REKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISA 818
Query: 1262 SPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVV 1321
S PLE+ E ++ LT ++ AE P P VT+ + E A + E
Sbjct: 819 SVTEPLEQVE-AEAAL---LTEEVLEREVIAEEEP--PTVTEPLPENREARGDTVVSEAE 872
Query: 1322 SPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERAS-VSPM 1380
++VT + P E S+ E E AV + +D+ D E A+ V +
Sbjct: 873 LTPEAVTAAETAGPLGAEEGTEASA--AEETTEMVSAVS---QLTDSPDTTEEATPVQEV 927
Query: 1381 DEPVPDSE-----------SPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPF 1429
+ VPD E + EKV + P G E + A+ AE P
Sbjct: 928 EGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAE-------AERPE 980
Query: 1430 EEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIK-------EDFGQEKK-TDDV 1481
E+ + S + + T L D QE K+ F K E F + + T+ +
Sbjct: 981 EQA--------EASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESI 1032
Query: 1482 EAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSD-KSATPVDEGVAE 1540
E SS+ L V ++ + Q + D S+ T S+ +TPV + A
Sbjct: 1033 E--SSELVTTCQAETLAGVKSQEMVMEQ--AIPPD---SVETPTDSETDGSTPVADFDAP 1085
Query: 1541 DTYS-------HMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTE---VDDSL 1590
T H E + T S T + P + P+ + V + E ++D+L
Sbjct: 1086 GTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTL 1145
Query: 1591 SVS----VVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMS 1646
+ V+T + +TE + ++ + P F T + R + + ++
Sbjct: 1146 EHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVA 1205
Query: 1647 I-----EFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSH 1701
+ E + + +L + +SP P V+ + E TE + P+ + + L H
Sbjct: 1206 LKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQV-EREKTEAE--PTHVNEEKLEH 1262
Query: 1702 K--IPPMEEPSYTQDNDLSELISVSQVEASPSTSS 1734
+ + EE S L + ++V ++ + SS
Sbjct: 1263 ETAVTVSEEVS----KQLLQTVNVPIIDGAKEVSS 1293
Score = 93.2 bits (230), Expect = 3e-18
Identities = 226/1119 (20%), Positives = 430/1119 (38%), Gaps = 194/1119 (17%)
Query: 558 RKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVK 617
+ E E ++ H ++P + + ++ + +K ++ ++ V+ + PS+E+P+P+
Sbjct: 244 KAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEK-VELPSEEQVSGSQGPSEEKPAPLA 302
Query: 618 AEV--------AEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPI 669
EV E+ +V +E+T +++T+V+ E+ + A+ ++ P
Sbjct: 303 TEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPA 362
Query: 670 KKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPK 729
K+ K K+ V E + + P ++V + PP+ V EV+ +E K + P
Sbjct: 363 KELVKLKETCVSGE---DPTQGADLSPDEKVLSK-PPEGVVSEVEMLSSQERMKVQGSPL 418
Query: 730 KE------IKKL--PKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGK 781
K+ +KKL K K E+ + + P +E K +S +A P+E +
Sbjct: 419 KKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGES-SASSPEEPEE 477
Query: 782 IKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFE 841
I ++K G A GAT+ G+ K++ + + P + K+ E
Sbjct: 478 ITCLEK-GLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDE 536
Query: 842 ELKAEEV----------DVTKDIKPQLELIEDEEKLKETEPVEAY-----VIQKEREVTK 886
K + ++ +++K +E + EE ++ + ++ V ++ +
Sbjct: 537 LDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARR 596
Query: 887 GPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDI---EKFEDEGAGFEESSETGDYE 943
G + + G G+ Q +E ++ G D I + D G G + G
Sbjct: 597 GSSSDEEGGPKAMGGD---HQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPT 653
Query: 944 E--------------KAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYI--- 986
E + + EE E+ + S +HS T D E K E+ I
Sbjct: 654 EGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHS-TPDTEPGKEESWVSIKKF 712
Query: 987 ----REKR-----------ESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDARE 1031
R+KR ++ +G + + D+ + E + E E E +A+ + E
Sbjct: 713 IPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAE 772
Query: 1032 E-------EYEPEKMEAEDYVM--AVVDKAAEAGGAEEQ-----YGFLTTPTKQLGAQSP 1077
+ E E E++ ++M AV D A EE+ +T P +Q+ A+
Sbjct: 773 QPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAE-- 830
Query: 1078 GREPASSIHDETLPGGSESEATASDE---------ENREDQPEEFTATSGYTQSTIEISS 1128
A+ + +E L E E A +E ENRE + + + + T + +
Sbjct: 831 ----AALLTEEVL----EREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAE 882
Query: 1129 EPTPMDEMSTPRDVMSDETN------NEETESP--SQEFVNITKYESSLYSQEYSKPADV 1180
P+ ++ET ++ T+SP ++E + + E + E +
Sbjct: 883 TAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQ 942
Query: 1181 TPLNGFSEGSKTDA----TDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTT 1236
L +E K ++ T G + + P E ++ A S +K T
Sbjct: 943 EVLQAVAEKVKEESQLPGTGGPE-----DVLQPVQRAEAER----PEEQAEASGLKKETD 993
Query: 1237 LDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP 1296
+ +K +E + K + + P EK P V S+ +E+ + +AE
Sbjct: 994 VVLKVDAQEAKTEPFTQGK--VVGQTTPESFEKAP----QVTESIESSELVTTCQAET-- 1045
Query: 1297 VSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSP-TDEKSS----HLPTE 1351
++ +QE+V E P+ V +P+ S T + + +P T +K H E
Sbjct: 1046 LAGVKSQEMVMEQAIPPD----SVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENE 1101
Query: 1352 VI-----------------EKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKV 1394
V E+PPA P SF F + E S M++ + ++ +
Sbjct: 1102 VASGTQSGGTEAEAVPAQKERPPA-PSSFVFQEETKEQ-----SKMEDTLEHTDKEV--- 1152
Query: 1395 LSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLY 1454
S + S E AD A + + PF E G +GS D VS T +
Sbjct: 1153 -----SVETVSILSKTEGTQEADQYADEKTKDVPFFE--GLEGSIDTGITVSREKVTEV- 1204
Query: 1455 QDKQEGKSTDFAPIKEDFGQEKKTDDVEAMS--SQPALALDERKLGDVSPTQIDVSQFGS 1512
+G+ T+ A K+D E ++ S + + ER+ + PT ++ +
Sbjct: 1205 --ALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEK--- 1259
Query: 1513 FKEDTKMSISEGTVSDKSAT---PVDEGVAEDTYSHMEG 1548
+ +T +++SE T P+ +G E S +EG
Sbjct: 1260 LEHETAVTVSEEVSKQLLQTVNVPIIDGAKE--VSSLEG 1296
Score = 84.3 bits (207), Expect = 1e-15
Identities = 307/1496 (20%), Positives = 533/1496 (35%), Gaps = 203/1496 (13%)
Query: 823 LEAERSLMSSPEDLTKDFEELKAEEVDVTKDIK-PQLELIEDEEKLKETEPVEAYVIQK- 880
+E S S+ E+LT+ E +A ++ K K + ++K ++ + V+ ++K
Sbjct: 48 IEQIPSSESNLEELTQPTES-QANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKD 106
Query: 881 EREVTKGPAESPDEGITTTEG---EGECEQTPEELEPVEK--QGVDDIEKFEDEGAGFEE 935
E E G + D + E E E +Q+ E+ E K Q +I + G EE
Sbjct: 107 EGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEE 166
Query: 936 SSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVAS 995
E G EEK E E ++ E + S + A R+ +E
Sbjct: 167 CKEEG--EEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVE 224
Query: 996 GDDRAEEDMDEAI---EKGEAE------QSEEEADEEDKAEDAREE----EYEPEKMEAE 1042
++ +E E + E G+AE + E+A ++ AE A E EYE ++ +E
Sbjct: 225 ASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSE 284
Query: 1043 DYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASD 1102
+ V + G +EE+ L T + E + +H T+ +E + T +
Sbjct: 285 EQV------SGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVE 338
Query: 1103 EENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNI 1162
E TA S + +E+ +EP +E E P++E V +
Sbjct: 339 E----------TAGSVPAEELVEMDAEP-------------------QEAE-PAKELVKL 368
Query: 1163 TKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSA 1222
E+ + ++ ++ AD++P + K S + SS E K S
Sbjct: 369 K--ETCVSGEDPTQGADLSP---------DEKVLSKPPEGVVSEVEMLSSQERMKVQGSP 417
Query: 1223 LRDAYCSE-VKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSL 1281
L+ + S +K + K E ++ P+ SP ++ GE S +
Sbjct: 418 LKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDS----QEEQKGESSASSPE 473
Query: 1282 TPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPT 1341
P EI E +A V + EE S +K E V+P S + P+
Sbjct: 474 EPEEI-TCLEKGLAEVQQDGE---AEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPS 529
Query: 1342 DEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSP 1401
+ + ++K + +S S A + E S ++EP P E P KV + +
Sbjct: 530 ESDKE----DELDKVKSATLSSTESTASEMQEEMKGS-VEEPKP--EEPKRKVDTSVSWE 582
Query: 1402 PLI--GSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQE 1459
LI GS S+ D+ G A +K+ + G D+ + + + S D +
Sbjct: 583 ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGK-DKETGTDGILAGSQEHDPGQ 641
Query: 1460 GKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKE---- 1515
G S+ E G + + V S L +K + + S GS E
Sbjct: 642 GSSSP-----EQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTP 696
Query: 1516 DTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLH 1575
DT+ E VS K P G + + A V A ++ + V P
Sbjct: 697 DTEPGKEESWVSIKKFIP---GRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL-- 751
Query: 1576 AEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPV 1635
+E + +++ + + P TE+S E M + + A T +
Sbjct: 752 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAA---TII 808
Query: 1636 QDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQ 1695
++ S S+ E E A+ +TE EV ++
Sbjct: 809 EERSPSWISASVTEPLEQVEAEAAL------------------LTE----EV------LE 840
Query: 1696 DSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAP 1755
++ + PP ++ + VS+ E +P A T ++ A PL + ++ +
Sbjct: 841 REVIAEEEPPTVTEPLPENREARGDTVVSEAELTPE---AVTAAETAGPLGAEEGTEASA 897
Query: 1756 PRDMSLYASLTSEKVQSLEG-EKLSPKSDISPLTP--RESSPLYSPTFSDSTSAVKEKTA 1812
+ + S S+ S + E+ +P ++ P E VKE++
Sbjct: 898 AEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQ 957
Query: 1813 TCHSSSSP----PIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGKTPGDF 1868
+ P+ A AE +A + + L D E + GK G
Sbjct: 958 LPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQT 1017
Query: 1869 SYAYQKPEETTRSPD-EEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYS---YE 1924
+ PE ++P E + T + + G +++ P DS + E
Sbjct: 1018 T-----PESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1072
Query: 1925 TIGKTTKTPEDG------DYSYEIIEKT---TRTPEEGGYSYDISEKTTSPPEVSGYSYE 1975
T G T D D EI E+ + T G + + + PP S + ++
Sbjct: 1073 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1132
Query: 1976 KTERSRRLLDDISNGYDDSEDGGHTLGDPS----------YSYETTEKITSFPESEGYSY 2025
+ + + ++D + D E T+ S Y+ E T+ + F EG S
Sbjct: 1133 EETKEQSKMEDTLE-HTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEG-SI 1190
Query: 2026 ETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLV 2085
+T +R T E A K T +A + +L A K PS +++ +
Sbjct: 1191 DTGITVSREKVT-----EVALKGEGTEEAECKKDDALELQSHA-KSPPSPVEREMVV--- 1241
Query: 2086 SSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDET 2145
+ + KTE P+ +N LE + +EE K L Q+ P G K+
Sbjct: 1242 ---QVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSP 1298
Query: 2146 PPTSVSESA--------PSQTDSDVPPETEECPSITADANI-----DSEDESETIPTDKT 2192
PP E A S+ + EE + ANI E + ++
Sbjct: 1299 PPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEK 1358
Query: 2193 VTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLK-EKTKTKK 2247
+ K+ D P +D P+ PD + + K L DL+ EKT + K
Sbjct: 1359 SSEKNEDFAAHPGEDAVPT--GPDCQAKSTPVI-VSATTKKGLSSDLEGEKTTSLK 1411
Score = 51.2 bits (121), Expect = 1e-05
Identities = 120/558 (21%), Positives = 214/558 (38%), Gaps = 92/558 (16%)
Query: 526 PTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVE---- 581
P+ V Q + K+++ ++L+ K + ++V SK E + EK V
Sbjct: 1126 PSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEG 1185
Query: 582 -----------SKEKVMVKKDKPIKTET----KPSVTEKEVPSKEEPSPVKAEVA---EK 623
S+EKV K TE K E + +K PSPV+ E+ E+
Sbjct: 1186 LEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVER 1245
Query: 624 QATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPK---------KEVAKKEDKTP--IKKE 672
+ T+ +P E+ ++ ET V ++ ++ KEV+ E P + +E
Sbjct: 1246 EKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQE 1305
Query: 673 E----KPKKEEVKKEVKKEIKKEEKK---EPKKEVKKETPPKEVKKEVKKEEKKEVKKEE 725
E K + + + EE+K E ++ + + EEK K E+
Sbjct: 1306 EAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNED 1365
Query: 726 --KEPKKEIKKLPKDAKKSSTPLS-------------EAKKPAALKPKVPKKEESVK--- 767
P ++ D + STP+ E +K +LK K + +E V
Sbjct: 1366 FAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQE 1425
Query: 768 -KDSVAAGKPK-EKGKIKVIKKEGKAAE-----AVAAAVGTGAT----------TAAVMA 810
K SVA + E G +++ K K + AV V T T T A +
Sbjct: 1426 VKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVI 1485
Query: 811 AAGIAAIGPAKELEAERSLMSSPED--LTKDFEELKAEEV-----DVTKDIKPQLE---L 860
A G E E E S+ ++ +T EE ++ V D++KD+ E
Sbjct: 1486 KADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMT 1545
Query: 861 IEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEE--LEPVEKQ 918
+E E + +E V+ E E +S E +G + E+ +EP E +
Sbjct: 1546 VEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPED----DGHALLAERIEKSLVEPKEDE 1601
Query: 919 GVDDIEKFEDEGAGFEESSETGDY-EEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEES 977
DD++ E++ + ++ +G +E +T ++ E++ + V + K D+
Sbjct: 1602 KGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAI 1661
Query: 978 AKAEADAYIREKRESVAS 995
+ +++RES S
Sbjct: 1662 TPQAQEELQKQERESAKS 1679
Score = 35.8 bits (81), Expect = 0.54
Identities = 102/451 (22%), Positives = 165/451 (36%), Gaps = 90/451 (19%)
Query: 1944 EKTTRTPEEGGYSYDISEKTTSPPEVSGYSYE--KTERSRRLLDDISNGYDD------SE 1995
+++T PEE + S SPP SG + E K E + + S + SE
Sbjct: 135 KQSTEKPEET-LKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSE 193
Query: 1996 DGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYE------TAEKIT 2049
G + + K TSF + + E S K E +EK+T
Sbjct: 194 TGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLT 253
Query: 2050 RTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEW 2109
+ QA + P+E+ + L S EY+ K EL P+ +
Sbjct: 254 ASEQA--------------HPQEPAESAHEPRL----SAEYE--KVEL------PSEEQV 287
Query: 2110 FASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEEC 2169
S+ P+EE PL A K + Q + VS + +T+ E
Sbjct: 288 SGSQGPSEEKPAPL-----ATEVFDEKIEVHQEEVVAEVHVS-TVEERTEEQKTEVEETA 341
Query: 2170 PSITADANIDSEDE-SETIPTDKTVTYKHM---DPPPAPVQDRSPSPR----HPDVSMVD 2221
S+ A+ ++ + E E P + V K P D SP + P+ + +
Sbjct: 342 GSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSE 401
Query: 2222 PEALAIEQNL------------GKALKKDLKEKTKTKKPG--------TKTKSSSPVKKS 2261
E L+ ++ + LKK +K K K+ G T+ + SP +
Sbjct: 402 VEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQE 461
Query: 2262 DGKSKPLAASPKPA--------GLKE-----SSDKVSRVASPKKKESVEKAA--KPTTTP 2306
+ K + A+SP+ GL E +++ + KK+E V A K TP
Sbjct: 462 EQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTP 521
Query: 2307 EVKAARGEEKDKETKNAANASASKSAKTATA 2337
+ + R E DKE + SA+ S+ +TA
Sbjct: 522 KKRVRRPSESDKEDELDKVKSATLSSTESTA 552
>gi|91982772 mucin 17 [Homo sapiens]
Length = 4493
Score = 104 bits (260), Expect = 9e-22
Identities = 287/1347 (21%), Positives = 467/1347 (34%), Gaps = 156/1347 (11%)
Query: 1083 SSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDE---MSTP 1139
SS+ +T PG S + T ++ + + +T+ + ST + SS TP MSTP
Sbjct: 96 SSVTSDT-PGVSSTRMTPTESRTTSESTSD--STTLFPSSTEDTSSPTTPEGTDVPMSTP 152
Query: 1140 RDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKD 1199
+ T + +P F Y S Y + S P + S + T K
Sbjct: 153 SEESISSTMAFVSTAPLPSF---EAYTSLTYKVDMSTPLTTSTQASSSPTTPESTTIPKS 209
Query: 1200 YNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSL 1259
N+ ST K + S + V+ ST + +ISA +S + ++ PSL
Sbjct: 210 TNSEGSTPLTSMPASTMKVASSEAITLLTTPVEISTPV----TISAQASSSPTTAEGPSL 265
Query: 1260 SPSPPS----PLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQ-EVVEEHCASPE 1314
S S PS PL + PL V VS+EA +P T V+ AS
Sbjct: 266 SNSAPSGGSTPLTRMPLSVMLV----------VSSEASTLSTTPAATNIPVITSTEASSS 315
Query: 1315 DKTLEVVSPSQSVTGSAGHTPYYQSPTD------EKSSHLPTEVIEKPPAVPVSFEFSDA 1368
T E S S T + G TP +P + S L ++ V S E S
Sbjct: 316 PTTAEGTSIPTS-TYTEGSTPLTSTPASTMPVATSEMSTLSITPVDTSTLVTTSTEPSSL 374
Query: 1369 KDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDK----ASGRG 1424
E S+ + + + +P+ + P+ + + SE++ S + D K +
Sbjct: 375 PTTAEATSM--LTSTLSEGSTPLTNM--PVSTILVASSEASTTSTIPVDSKTFVTTASEA 430
Query: 1425 AESP--FEEKSGKQGSPDQVS-PVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDV 1481
+ SP E+ S +P + S P++ M ++ E + P+ + + T
Sbjct: 431 SSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVASSEASNLSTTPVD---SKTQVTTST 487
Query: 1482 EAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED 1541
EA SS P ++ S ++ + M ++ S S TPVD
Sbjct: 488 EASSSPPTAEVNSMPTSTPSEGSTPLTSMSV----STMPVASSEASTLSTTPVDTSTPVT 543
Query: 1542 TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF 1601
T S AS S+ + +S P T + S L P ST + S S T
Sbjct: 544 TSSE----ASSSSTTPEGTSIPTSTPSEGSTPL---TNMPVSTRLVVSSEASTTSTTPAD 596
Query: 1602 QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMD 1661
T ++ S E A S + + S +S E G S++
Sbjct: 597 SNTFVTTSSE-----------------ASSSSTTAEGTSMPTSTYSERGTTITSMSVSTT 639
Query: 1662 FSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDND--LSE 1719
S A L T + ++ SS + + M +YT+ + S
Sbjct: 640 LVASSE------ASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSM 693
Query: 1720 LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPR--DMSLYASLTSEKVQSLEGEK 1777
++ + V +S +++ + TP ++P+ T + +P S+ S SE L
Sbjct: 694 PVNTTLVASSEASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSMP 753
Query: 1778 LSPKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCH----SSSSPPIDAASAEPYGFR 1833
+S + LT E+S L + ST A+C +S PI S E
Sbjct: 754 VSK----TLLTSSEASTLSTTPLDTSTHITTSTEASCSPTTTEGTSMPISTPS-EGSPLL 808
Query: 1834 ASVLFDTMQHHLALNRDLSTPGLEKDSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYE 1893
S+ LST ++ +S T + S + P E T P Y
Sbjct: 809 TSIPVSITPVTSPEASTLSTTPVDSNSPVTTSTEVS-SSPTPAEGTSMP-TSTYSEGRTP 866
Query: 1894 KTTRTSDVGGYYYEKIERTTKSPSDSG--YSYETIGKTTKTPEDGDYSYEIIEKTTRTPE 1951
T+ I + +P D+ + T +++ T +G T TP
Sbjct: 867 LTSMPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEG------TSMPTSTPG 920
Query: 1952 EGGYSYDISEKTTSP---PEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDPSYSY 2008
EG +T+P E S + S + + G ++ + S
Sbjct: 921 EGSTPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPS- 979
Query: 2009 ETTEKITSFPESEGY--SYETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCY 2066
E T +TS P S + E ST +T D++T + E + P A S TS
Sbjct: 980 EGTTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTS---- 1035
Query: 2067 TAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQS 2126
T + S R V +V+S E S ++ P + ++ T +
Sbjct: 1036 TPSEGSTPLTRMPVSTTMVASSE---------TSTLSTTPADTSTPVTTYSQASSSSTTA 1086
Query: 2127 GGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESET 2186
G P +G TP TSV S S+ T + + + E+ +
Sbjct: 1087 DGTSMPTSTYSEG----STPLTSVPVSTRLVVSSEA--STLSTTPVDTSIPVTTSTEASS 1140
Query: 2187 IPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTK 2246
PT T PP P SM L + + KT+
Sbjct: 1141 SPTTAEGTSIPTSPPSEGTT--------PLASMPVSTTLVVSSEANTLSTTPVDSKTQV- 1191
Query: 2247 KPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTP 2306
T T++SSP ++ S P + + + S + + ++ + T+TP
Sbjct: 1192 --ATSTEASSPPPTAEVTSMPTSTPGERSTPLTSMPVRHTPVASSEASTLSTSPVDTSTP 1249
Query: 2307 EVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVPPGLPVYLDLCYIPNH 2366
+A ET ++ + S T+T G+T T +PV L P
Sbjct: 1250 VTTSA-------ETSSSPTTAEGTSLPTSTTSEGSTLLT-------SIPVSTTLVTSPEA 1295
Query: 2367 SNSKNVDVEFFKRVRSSYYVVSGNDPA 2393
S V+ V +S V S PA
Sbjct: 1296 STLLTTPVDTKGPVVTSNEVSSSPTPA 1322
Score = 94.0 bits (232), Expect = 2e-18
Identities = 294/1387 (21%), Positives = 471/1387 (33%), Gaps = 190/1387 (13%)
Query: 1074 AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTA------TSGYTQSTIEIS 1127
+ SP +S+ T GS + PE T T G ++ E+S
Sbjct: 1257 SSSPTTAEGTSLPTSTTSEGSTLLTSIPVSTTLVTSPEASTLLTTPVDTKGPVVTSNEVS 1316
Query: 1128 SEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD-VTPLNGF 1186
S PTP + S P S E T P VN T SS S + P D TP+
Sbjct: 1317 SSPTPAEGTSMPTSTYS-EGRTPLTSIP----VNTTLVASSAISILSTTPVDNSTPVTTS 1371
Query: 1187 SEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAV 1246
+E + T +++ + + S + + + S + A T +D +
Sbjct: 1372 TEACSSPTTSEGTSMPNSNPSEGTTPLTSIPVSTTPVVSSEASTLSA-TPVDTSTPGTTS 1430
Query: 1247 SSEKVSPSKSPSLSPSPPSPLE-KTPLGERSVNFSLTPNEIKVSAEAEVAPV---SPEVT 1302
+ SP+ + +S +P E KTPL +S+ S TP ++ PV SP VT
Sbjct: 1431 AEATSSPTTAEGISIPTSTPSEGKTPL--KSIPVSNTPVANSEASTLSTTPVDSNSPVVT 1488
Query: 1303 QEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAV--- 1359
V E ++ + +PS+ GS T S T SS + + + PAV
Sbjct: 1489 STAVSSSPTPAEGTSIAISTPSE---GSTALTSIPVSTTTVASSEINS--LSTTPAVTST 1543
Query: 1360 PVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDK 1419
PV+ + S + +P+ + P+ + ++ SE+ S D K
Sbjct: 1544 PVTTYSQASSSPTTADGTSMQTSTYSEGSTPLTSL--PVSTMLVVSSEANTLSTTPIDSK 1601
Query: 1420 ----ASGRGAESPFEEKSGKQ-GSPDQVSP-VSEMTSTSLYQDKQEGKSTDFAPIKEDFG 1473
AS + S E S +P + SP ++ + ++ E + P+ +
Sbjct: 1602 TQVTASTEASSSTTAEGSSMTISTPSEGSPLLTSIPVSTTPVASPEASTLSTTPVDSNSP 1661
Query: 1474 QEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMS--ISEGTVSDKSA 1531
T+ +SS P A G PT T + ++ +S S
Sbjct: 1662 VITSTE----VSSSPTPA-----EGTSMPTSTYTEGRTPLTSITVRTTPVASSAISTLST 1712
Query: 1532 TPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTD-------DVSPSLHAEVGSPHST 1584
TPVD T + + S + +S P T +P L +E + +T
Sbjct: 1713 TPVDNSTPVTTSTEARSSPTTSEGTSMPNSTPSEGTTPLTSIPVSTTPVLSSEASTLSAT 1772
Query: 1585 EVDDS----LSVSVVQTPTTFQETEMSPSK-EECPRPMSISPPDF-----SPKTAKSRTP 1634
+D S S +PTT + T + S E P++ +P S + S TP
Sbjct: 1773 PIDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGMTPLTSTPVSHTLVANSEASTLSTTP 1832
Query: 1635 VQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDM 1694
V + +S ++ SP + + +P G +T + + S+
Sbjct: 1833 VDSNSPVVTSTAV---SSSPTPAEGTSIATSTPSE-----GSTALTSIPVSTTTVASSET 1884
Query: 1695 QDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVA 1754
S + + +Y Q +S S A S+ TP + PL +S
Sbjct: 1885 NTLSTTPAVTSTPVTTYAQ-------VSSSPTTADGSSMPTSTPREGRPPLTSIPVST-- 1935
Query: 1755 PPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATC 1814
++ S ++ +L ++ ++ + SSP + S T A E +
Sbjct: 1936 --------TTVASSEINTLSTTLADTRTPVTTYSQASSSPTTADGTSMPTPAYSEGSTPL 1987
Query: 1815 HSSSSPPIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGKTP---GDFSYA 1871
S S+E AS L T D STP G +P G S
Sbjct: 1988 TSMPLSTTLVVSSE-----ASTLSTTPV-------DTSTPATTSTEGSSSPTTAGGTSIQ 2035
Query: 1872 YQKPEETTR----SPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYSYETIG 1927
P E T P S T T+ V K + T + + S + E
Sbjct: 2036 TSTPSERTTPLAGMPVSTTLVVSSEGNTLSTTPVD----SKTQVTNSTEASSSATAEGSS 2091
Query: 1928 KTTKTPEDGDYSYEIIEKTT---RTPEEGGYS----------YDISEKTTSPPEVSGYSY 1974
T P +G I +T +PE S +E ++SP G S
Sbjct: 2092 MTISAPSEGSPLLTSIPLSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPIPTEGTSM 2151
Query: 1975 EKTERSRRLLDDISNGYDDSEDGGHTLGDPSYS-YETTEKITSFPE-------SEGYSYE 2026
+ + S R S + + S + +T+ +T+ E SEG S
Sbjct: 2152 QTSTYSDRRTPLTSMPVSTTVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMP 2211
Query: 2027 TSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSD----LCYTAEKKSPSEARQDVDL 2082
TST + + ++ T + T +AST S D + + E S + +
Sbjct: 2212 TSTPSEGSTPFTSMPVSTMPVV--TSEASTLSATPVDTSTPVTTSTEATSSPTTAEGTSI 2269
Query: 2083 CLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQC 2142
+ E P T + S E +S P T S A P
Sbjct: 2270 PTSTLSEGTTPLTSIPVSHTLVANSEVSTLSTTPVDSNTPFTTSTEASSP---------- 2319
Query: 2143 DETPPTSVSESAPSQTDSD-VPPETEECPSITADANIDSEDESETIPTDKT---VTYKHM 2198
PPT+ S P+ T S+ P T S T A+ ++ S T P D + TY
Sbjct: 2320 ---PPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLS-TTPADTSTPVTTYSQA 2375
Query: 2199 DPPPAPVQDRS-PSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSP 2257
P D S P+ + + S L + P +++S+
Sbjct: 2376 GSSPTTADDTSMPTSTYSEGS------------------TPLTSVPVSTMPVVSSEASTH 2417
Query: 2258 VKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKP-TTTPEVKAARG--- 2313
S P+ S + + +++ S SP + + A+ P +TTP V + G
Sbjct: 2418 STTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSSEAGTLS 2477
Query: 2314 -EEKDKETKNAANASASKSAKTA--------TAGPGTTKTTK--SSAVPPGLPVYLDLCY 2362
D T + AS S TA TA G+T T S P P L
Sbjct: 2478 TTPVDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTTPVASPEASTLST 2537
Query: 2363 IPNHSNS 2369
P SNS
Sbjct: 2538 TPVDSNS 2544
Score = 87.8 bits (216), Expect = 1e-16
Identities = 295/1378 (21%), Positives = 472/1378 (34%), Gaps = 192/1378 (13%)
Query: 1052 AAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPE 1111
+AEA + ++ PT S G+ P SI P + +T S + P
Sbjct: 1430 SAEATSSPTTAEGISIPTS---TPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPV 1486
Query: 1112 EFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYS 1171
T+T+ +SS PTP + S ++ T +E + + + V+ T SS +
Sbjct: 1487 -VTSTA--------VSSSPTPAEGTS-----IAISTPSEGSTALTSIPVSTTTVASSEIN 1532
Query: 1172 QEYSKPADV-TPLNGFSEGSKTDAT-DGKDYNASASTISPPSSMEEDKFSRSALRDAYCS 1229
+ PA TP+ +S+ S + T DG + ST S S+ + L + +
Sbjct: 1533 SLSTTPAVTSTPVTTYSQASSSPTTADGT--SMQTSTYSEGSTPLTSLPVSTMLVVSSEA 1590
Query: 1230 EVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVS 1289
++T +D K ++A S+E S + + S + +P E +PL S+ S TP +
Sbjct: 1591 NTLSTTPIDSKTQVTA-STEASSSTTAEGSSMTISTPSEGSPL-LTSIPVSTTPVASPEA 1648
Query: 1290 AEAEVAPV---SPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSS 1346
+ PV SP +T V E ++ + ++ T T S
Sbjct: 1649 STLSTTPVDSNSPVITSTEVSSSPTPAEGTSMPTSTYTEGRTPLTSITVRTTPVASSAIS 1708
Query: 1347 HLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGS 1406
L T ++ V S E + +E S+ P P + +P+ + P+ + P++ S
Sbjct: 1709 TLSTTPVDNSTPVTTSTEARSSPTTSEGTSM-PNSTP-SEGTTPLTSI--PVSTTPVLSS 1764
Query: 1407 ESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFA 1466
E+ S LSA +P D +PV+ T + EG S +
Sbjct: 1765 EA---STLSA----------TPI----------DTSTPVTTSTEATSSPTTAEGTSIPTS 1801
Query: 1467 PIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQI---DVSQFGSFKEDTKMSISE 1523
+ E + ++S P VS T + + S + D+ +
Sbjct: 1802 TLSEG---------MTPLTSTP-----------VSHTLVANSEASTLSTTPVDSNSPVVT 1841
Query: 1524 GTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHS 1583
T S TP EG + T + EG S A +S P TT S + +P
Sbjct: 1842 STAVSSSPTPA-EGTSIATSTPSEG-------STALTSIPVSTTTVASSETNTLSTTPAV 1893
Query: 1584 TEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPP------------DFSPKTAKS 1631
T + V +PTT + M S RP S P S A +
Sbjct: 1894 TSTPVTTYAQVSSSPTTADGSSMPTSTPREGRPPLTSIPVSTTTVASSEINTLSTTLADT 1953
Query: 1632 RTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSP 1691
RTPV + SS + G P + +S S ++ + + + + +P
Sbjct: 1954 RTPVTTYSQASSSPTTADGTSMPTPA----YSEGSTPLTSMPLSTTLVVSSEASTLSTTP 2009
Query: 1692 SDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPL------ 1745
D P+ T S + ST S T P+
Sbjct: 2010 VD------------TSTPATTSTEGSSSPTTAGGTSIQTSTPSERTTPLAGMPVSTTLVV 2057
Query: 1746 --QEDTLSDVAPPRDMSLYASLTSEKVQSLEGEK--LSPKSDISPL---TPRESSPLYSP 1798
+ +TLS + S + + EG +S S+ SPL P ++P+ SP
Sbjct: 2058 SSEGNTLSTTPVDSKTQVTNSTEASSSATAEGSSMTISAPSEGSPLLTSIPLSTTPVASP 2117
Query: 1799 TFSD-STSAVKEK----TATCHSSSSPPIDAASAE--PYGFRASVLFD-----TMQHHLA 1846
S ST+ V T+T SSS P + S + Y R + L T+ A
Sbjct: 2118 EASTLSTTPVDSNSPVITSTEVSSSPIPTEGTSMQTSTYSDRRTPLTSMPVSTTVVASSA 2177
Query: 1847 LNR------DLSTPGLEKDSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSD 1900
++ D STP +P + T +P E + S +T
Sbjct: 2178 ISTLSTTPVDTSTPVTNSTEARSSP----TTSEGTSMPTSTPSEGSTPFTSMPVSTMP-- 2231
Query: 1901 VGGYYYEKIERTTKSPSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGG---YSY 1957
+ + +P D+ T + T +P + E T T EG S
Sbjct: 2232 ---VVTSEASTLSATPVDTSTPVTTSTEATSSPT----TAEGTSIPTSTLSEGTTPLTSI 2284
Query: 1958 DISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSF 2017
+S + EVS S + + G ++ S S E +T
Sbjct: 2285 PVSHTLVANSEVSTLSTTPVDSNTPFTTSTEASSPPPTAEGTSM-PTSTSSEGNTPLTRM 2343
Query: 2018 PESEGY--SYETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSE 2075
P S S+ETST +T DTST ++ + A S TS +E +P
Sbjct: 2344 PVSTTMVASFETSTLSTTPADTSTPVTTYSQAGSSPTTADDTSMPTSTY---SEGSTPLT 2400
Query: 2076 ARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGG 2135
+ + +VSS H T + S P AS PT + S PP G
Sbjct: 2401 SVPVSTMPVVSSEASTHSTTPVDTS--TPVTTSTEASSSPTTAEGTSIPTS---PPSEGT 2455
Query: 2136 KQQGRQCDETPPTSVSE-----SAPSQTDSDVPPETEECPSITADAN----IDSEDESET 2186
T P SE + P T + + TE S T + I + E T
Sbjct: 2456 TPLASMPVSTTPVVSSEAGTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTASEGST 2515
Query: 2187 IPTDKTVTYKHMDPPPA------PVQDRSPSPRHPDV--SMVDPEALAIEQNLGKALKKD 2238
+ T V+ + P A PV SP ++ S E ++ +
Sbjct: 2516 LLTSIPVSTTPVASPEASTLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTP 2575
Query: 2239 LKEKTKTKKP----GTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKK- 2293
L+ + KP T S++PV S + S P K++S +S +
Sbjct: 2576 LRSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDTSMPISTPSEVSTSL 2635
Query: 2294 ESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVP 2351
S+ + P + E D T + S S TA T T + P
Sbjct: 2636 TSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTPGERSTP 2693
Score = 87.4 bits (215), Expect = 2e-16
Identities = 303/1430 (21%), Positives = 501/1430 (35%), Gaps = 179/1430 (12%)
Query: 1053 AEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEE 1112
++AG + + PT S G P +S+ T+P S +T S P
Sbjct: 2373 SQAGSSPTTADDTSMPTS---TYSEGSTPLTSVPVSTMPVVSSEASTHSTTPVDTSTPVT 2429
Query: 1113 FTATSGYTQSTIEISSEPT-PMDEMSTP--------RDVMSDETNNEETESPSQEFVNIT 1163
+ + + +T E +S PT P E +TP V+S E T T
Sbjct: 2430 TSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSSEAGTLSTTPVDTSTPMTT 2489
Query: 1164 KYESSLYSQEYSKPADVTPLNGFSEGS------------------KTDATDGKDYNA--- 1202
E+S S + V P++ SEGS T +T D N+
Sbjct: 2490 STEAS--SSPTTAEDIVVPISTASEGSTLLTSIPVSTTPVASPEASTLSTTPVDSNSPVV 2547
Query: 1203 ------SASTISPPSSMEEDKFSRSAL---------RDAYCSEVKASTTLDIKDSISAVS 1247
S++T + +SM +S + + SE +T + SI +
Sbjct: 2548 TSTEISSSATSAEGTSMPTSTYSEGSTPLRSMPVSTKPLASSEASTLSTTPVDTSIPVTT 2607
Query: 1248 SEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVE 1307
S + S SP+ + P+ S+ L S+EA +P T+ +V
Sbjct: 2608 STETS--SSPTTAKDTSMPISTPSEVSTSLTSILVSTMPVASSEASTLSTTPVDTRTLVT 2665
Query: 1308 EHCASPEDKTLEVVSPSQSVTGSAGHTPYYQ---SPT---DEKSSHLPTEVIEKPPAVPV 1361
+ T S + T TP S T + ++S L T ++ V
Sbjct: 2666 TSTGTSSSPTTAEGSSMPTSTPGERSTPLTNILVSTTLLANSEASTLSTTPVDTSTPVTT 2725
Query: 1362 SFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDK-- 1419
S E S + E S+ + P D +P+ +L + + P+ SE++ S + D
Sbjct: 2726 SAEASSSPTTAEGTSMR-ISTP-SDGSTPLTSIL--VSTLPVASSEASTVSTTAVDTSIP 2781
Query: 1420 --ASGRGAESPF--EEKSGKQGSPDQVS-PVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQ 1474
S + SP E S +P + S P++ M E + P+
Sbjct: 2782 VTTSTEASSSPTTAEVTSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPV 2841
Query: 1475 EKKTDDVEAMSSQPALA------LDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSD 1528
T SS P A + G T I VS T ++ SE S
Sbjct: 2842 TTSTK----ASSSPTTAEGIVVPISTASEGSTLLTSIPVST-------TPVASSEA--ST 2888
Query: 1529 KSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGS--PHSTEV 1586
S TPVD + T + EG +S +TA +S P T +VS L + + S P +
Sbjct: 2889 LSTTPVDTSIPVTTST--EGSSSPTTAE--GTSMPISTPSEVSTPLTSILVSTVPVAGSE 2944
Query: 1587 DDSLSVSVVQTPT---TFQETEMSPSKEE-CPRPMSISPPDFSPKTAKSRTPVQDHRSEQ 1642
+LS + V T T T E SP+ E P+S +P T+ S + + SE
Sbjct: 2945 ASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEA 3004
Query: 1643 SSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHK 1702
S++S + + S + S ++ PT G I + P+E + + S+
Sbjct: 3005 STLS----RTPADTSTPVTTSTEASSSPTTAEGT-GIPISTPSEGSTPLTSIPVSTTPVA 3059
Query: 1703 IPPMEEPSYTQDNDLSELISVSQVEASPSTSSA-----HTPSQIASPLQEDTLSDV---- 1753
IP S T + S +++ ++V +SP+ + T S+ ++PL +S
Sbjct: 3060 IPEASTLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPISTYSEGSTPLTGVPVSTTPVTS 3119
Query: 1754 -------APPRDMSLYASLTSEKVQS---LEGEKL---SPKSDISPLTPRESSPLYSPTF 1800
P D S + ++E S EG + +P +PLT S + +
Sbjct: 3120 SAISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSS 3179
Query: 1801 SDST-SAVKEKTATCHSSSSPPIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKD 1859
DST SA T+T ++S+ + +AE S + M ++ +TP +
Sbjct: 3180 EDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVS-NTPVASSE 3238
Query: 1860 SG--GKTPGDFSYAYQKPEETTRSPDEED-----YDYESYEKTTRTS-DVGGYYYEKIER 1911
+ TP D + E + SP + S T TS V E
Sbjct: 3239 ASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSET 3298
Query: 1912 TTKS--PSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSYDISEKTTSP--- 1966
+T S P+D+ T + + +P D + T T EG +T+P
Sbjct: 3299 STLSTTPADTSTPVTTYSQASSSPPIADGT----SMPTSTYSEGSTPLTNMSFSTTPVVS 3354
Query: 1967 PEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEG--YS 2024
E S S + S + + G ++ S S E T + S P S S
Sbjct: 3355 SEASTLSTTPVDTSTPVTTSTEASLSPTTAEGTSIPTSSPS-EGTTPLASMPVSTTPVVS 3413
Query: 2025 YETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSE--------- 2075
E +T +T D++T + E + A S TS T+E +P
Sbjct: 3414 SEVNTLSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTST---TSEGSTPLSIMPLSTTPV 3470
Query: 2076 ARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTE-ESEKPLTQSGGAPPPPG 2134
A + + + P T SP+ +P E + T E PLT + P
Sbjct: 3471 ASSEASTLSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVA 3530
Query: 2135 GKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKT-V 2193
+ T P + S + + P T + ++ + T+ T V
Sbjct: 3531 SSEASTL--STTPVDSNTFVTSSSQASSSPATLQVTTMRMSTPSEGSSSLTTMLLSSTYV 3588
Query: 2194 TYKHMDPPPAPVQDRSP---SPRHPDVSMVDPEALAIEQNLGKALKKDLK----EKTKTK 2246
T P P DRS + + + PE + + + + L T
Sbjct: 3589 TSSEASTPSTPSVDRSTPVTTSTQSNSTPTPPEVITLPMSTPSEVSTPLTIMPVSTTSVT 3648
Query: 2247 KPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTP 2306
T S+ PV S +P + SS V+ + + + + P TT
Sbjct: 3649 ISEAGTASTLPVDTS---------TPVITSTQVSSSPVTPEGTTMPIWTPSEGSTPLTTM 3699
Query: 2307 EVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVPPGLPV 2356
V R + T + + S T+T ++ T S+ + +P+
Sbjct: 3700 PVSTTRVTSSEGSTLSTPSVVTSTPVTTSTEAISSSATLDSTTMSVSMPM 3749
Score = 67.8 bits (164), Expect = 1e-10
Identities = 160/762 (20%), Positives = 277/762 (36%), Gaps = 103/762 (13%)
Query: 1076 SPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM-D 1134
S G P S + T P S +T S P ++ + + +T E++S PT
Sbjct: 3454 SEGSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTAG 3513
Query: 1135 EMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDA 1194
E STP M V+ T SS S + P D N F S +
Sbjct: 3514 EGSTPLTNMP---------------VSTTPVASSEASTLSTTPVDS---NTFVTSSSQAS 3555
Query: 1195 TDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPS 1254
+ + +S PS + L Y + +AST + S S V+ S
Sbjct: 3556 SSPATLQVTTMRMSTPSE-GSSSLTTMLLSSTYVTSSEASTP----STPSVDRSTPVTTS 3610
Query: 1255 KSPSLSPSPP--------SPLE-KTPLGERSVNF-SLTPNEIKVSAEAEVAPVSPEVTQE 1304
+ +P+PP +P E TPL V+ S+T +E ++ V +P +T
Sbjct: 3611 TQSNSTPTPPEVITLPMSTPSEVSTPLTIMPVSTTSVTISEAGTASTLPVDTSTPVITST 3670
Query: 1305 VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSP------TDEKSSHLPTEVIEKPPA 1358
V +PE T+ + +PS+ G TP P T + S L T +
Sbjct: 3671 QVSSSPVTPEGTTMPIWTPSE------GSTPLTTMPVSTTRVTSSEGSTLSTPSVVTSTP 3724
Query: 1359 VPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADD 1418
V S E +S + +D P+E +S L + L+ + ++
Sbjct: 3725 VTTSTE--------AISSSATLDSTTMSVSMPME--ISTLGTTILVSTTP-----VTRFP 3769
Query: 1419 KASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKT 1478
++S S + S S SP + +T++ +ST +
Sbjct: 3770 ESSTPSIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSERSTLLTTVLISPISVMSP 3829
Query: 1479 DDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGV 1538
+ +S+ P GD S + ++ GSF +++ +++ + +TP+ +
Sbjct: 3830 SEASTLSTPP---------GDTSTPLLTSTKAGSFSIPAEVTTIRISITSERSTPLTTLL 3880
Query: 1539 AEDTY-SHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQT 1597
T + G + ST + TS+ P+TD S + V ++SVSV+
Sbjct: 3881 VSTTLPTSFPGASIASTPPLDTSTTFTPSTD---------TASTPTIPVATTISVSVITE 3931
Query: 1598 PTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQS 1657
+T T PS P++ S D P T + + +E ++ S + S
Sbjct: 3932 GSTPGTTIFIPS-----TPVTSSTADVFPATTGAVSTPVITSTELNTPSTSSSSTTTSFS 3986
Query: 1658 LAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPS---DMQDSSLSHKIPPMEEPSYTQD 1714
+F+ + T A + ++T + + S S+LS P S T
Sbjct: 3987 TTKEFTTPA---MTTAAPLTYVTMSTAPSTPRTTSRGCTTSASTLSATSTPHTSTSVT-- 4041
Query: 1715 NDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLE 1774
+ ++ S + PST ++HT P T PP + ++ E V ++
Sbjct: 4042 ---TRPVTPSSESSRPSTITSHTIPPTFPPAHSST-----PPTTSASSTTVNPEAVTTMT 4093
Query: 1775 GE-KLSPKSDISPLTPRESSPLYSPTFSDSTSA-VKEKTATC 1814
K S ++ P + P + S+ TS +T TC
Sbjct: 4094 TRTKPSTRTTSFPTVTTTAVPTNTTIKSNPTSTPTVPRTTTC 4135
Score = 65.9 bits (159), Expect = 5e-10
Identities = 186/917 (20%), Positives = 310/917 (33%), Gaps = 128/917 (13%)
Query: 1498 GDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASV 1557
G S ++ + S + +M+ E +V+ S TP GV+ + E + + S
Sbjct: 70 GTTSTNVVEPRMYLSCSTNPEMTSIESSVT--SDTP---GVSSTRMTPTESRTTSESTSD 124
Query: 1558 ATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPT----TFQETEMSPSKEEC 1613
+T+ FP T D SP+ P ST ++S+S ++ T +F+ K +
Sbjct: 125 STTLFPSSTEDTSSPTTPEGTDVPMSTPSEESISSTMAFVSTAPLPSFEAYTSLTYKVDM 184
Query: 1614 PRPMSIS-PPDFSPKTAKSRTPVQDHRSE---------------QSSMSIEFGQESPEQS 1657
P++ S SP T +S T + SE SS +I E S
Sbjct: 185 STPLTTSTQASSSPTTPESTTIPKSTNSEGSTPLTSMPASTMKVASSEAITLLTTPVEIS 244
Query: 1658 LAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPS----DMQDSSLSHKIPPMEEPSYTQ 1713
+ S Q+ PT T GP+ + +PS + LS + E S
Sbjct: 245 TPVTISAQASSSPT--------TAEGPSLSNSAPSGGSTPLTRMPLSVMLVVSSEASTLS 296
Query: 1714 DNDLSELISV-SQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQS 1772
+ I V + EAS S ++A S S E + + P AS
Sbjct: 297 TTPAATNIPVITSTEASSSPTTAEGTSIPTSTYTEGSTPLTSTP------ASTMPVATSE 350
Query: 1773 LEGEKLSPKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSSSP----PIDAASAE 1828
+ ++P D S L + P PT +++TS + T+T S+P P+
Sbjct: 351 MSTLSITP-VDTSTLVTTSTEPSSLPTTAEATSML---TSTLSEGSTPLTNMPVSTILV- 405
Query: 1829 PYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGKTPGDFSYAYQKPEETTRSPDEEDYD 1888
AS T ++ T E S T D S A P E
Sbjct: 406 -----ASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSE----------- 449
Query: 1889 YESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTR 1948
S T+ + + +P DS T + + +P + E+ T
Sbjct: 450 -GSTPLTSMPVSTTPVASSEASNLSTTPVDSKTQVTTSTEASSSPP----TAEVNSMPTS 504
Query: 1949 TPEEGG---YSYDISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDPS 2005
TP EG S +S + E S S + S + + G ++ +
Sbjct: 505 TPSEGSTPLTSMSVSTMPVASSEASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTST 564
Query: 2006 YSYETTEKITSFPESEG--YSYETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSD 2063
S E + +T+ P S S E ST +T D++T+ ++E + + A S TS
Sbjct: 565 PS-EGSTPLTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTS- 622
Query: 2064 LCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPL 2123
T ++ + V LV+S E S ++ P++ + E+
Sbjct: 623 ---TYSERGTTITSMSVSTTLVASSE---------ASTLSTTPVDSNTPVTTSTEATSSS 670
Query: 2124 TQSGGAPPPPGGKQQG------------------RQCDETPPTSVSESAPSQTDSDVPPE 2165
T + G P +G T P S + T++ P
Sbjct: 671 TTAEGTSMPTSTYTEGSTPLTSMPVNTTLVASSEASTLSTTPVDTSTPVTTSTEASSSPT 730
Query: 2166 TEECPSITADANIDSEDESETIPTDKTVTYKH----MDPPPAPVQDRSPSPRHPDVSMVD 2221
T + S+ + ++P KT+ + P + S
Sbjct: 731 TADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLSTTPLDTSTHITTSTEASCSPTT 790
Query: 2222 PEALAI---EQNLGKALKKDLKEK-TKTKKPGTKTKSSSPVKKSD--GKSKPLAASPKPA 2275
E ++ + G L + T P T S++PV + S +++SP PA
Sbjct: 791 TEGTSMPISTPSEGSPLLTSIPVSITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPA 850
Query: 2276 -GLKESSDKVSRVASPKKKESVE------KAAKPTTTPEVKAARGEEKDKETKNAANASA 2328
G + S +P V A +T V + E +++ S
Sbjct: 851 EGTSMPTSTYSEGRTPLTSMPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSE 910
Query: 2329 SKSAKTATAGPGTTKTT 2345
S T+T G G+T T
Sbjct: 911 GTSMPTSTPGEGSTPLT 927
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 103 bits (258), Expect = 2e-21
Identities = 186/809 (22%), Positives = 318/809 (39%), Gaps = 126/809 (15%)
Query: 528 PVVKQTKLKQRADS--RESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVE-SKE 584
P + +T K R + E+ + LPS+ ++E + + K + ++
Sbjct: 917 PELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERD 976
Query: 585 KVMVKKDKPIKTETKPSVTEKE---VPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKE 641
K K DK + +V++KE P+K V E ++ K AKE+T K +
Sbjct: 977 KPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTD 1036
Query: 642 -TKVKPEDKKEEK--EKPKKEVAKKEDKTPIKKEEKPKKEE-VKKEVKKEIKKEEKKEPK 697
TK +K+EK P+K +K + +E KP KEE VKK+ K++K E K
Sbjct: 1037 NTKSSSSSQKDEKITGTPRKAHSKSAKE---HQETKPVKEEKVKKDYSKDVKSE--KLTT 1091
Query: 698 KEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPA---A 754
KE K + P ++ K K EK++ K EEK K+ + K S ++E KP+
Sbjct: 1092 KEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFES--SSMKISKLEVTEIVKPSPKRK 1149
Query: 755 LKPKVPKKEESVKKDSVAAGKPKEK-------------------------------GKIK 783
++P K + + +KD ++ P +K K+K
Sbjct: 1150 MEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVK 1209
Query: 784 VIKKEGKAAEAVAAAVGTGATT---AAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDF 840
K +GK V G+ +T + + G ++ + +R+++ + E+ D
Sbjct: 1210 QEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNND- 1268
Query: 841 EELKAEEVDVTKDIKPQLELIED-----EEKLKETEPVEAYVIQKEREVTKGPAESPDEG 895
AE+V + + PQ + +D EE +K T+P+ + + K V K + P
Sbjct: 1269 NTAPAEDVIIMIQV-PQSKWDKDDFESEEEDVKSTQPISS--VGKPASVIKNVSTKPSNI 1325
Query: 896 ITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPE 955
+ E +E EP EK I+KF + S E +E K+ A
Sbjct: 1326 VKYPE---------KESEPSEK-----IQKFTK-----DVSHEIIQHEVKSSKNSA---- 1362
Query: 956 EDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKG---E 1012
+S+ T+D + + E + EKR++ S E ++D E+G
Sbjct: 1363 ----------SSEKGKTKDRDYSVLEKEN--PEKRKN--STQPEKESNLDRLNEQGNFKS 1408
Query: 1013 AEQSEEEADEEDKAEDAR---EEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPT 1069
QS +EA DK + R +++ P + + DY + E +P+
Sbjct: 1409 LSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPS 1468
Query: 1070 KQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISS- 1128
+ + S + D G +S+ + S +R+ +P + AT + E S
Sbjct: 1469 RNKDSASGQKNKPREERDLPKKGTGDSKKSNS-SPSRDRKPHDHKATYDTKRPNEETKSV 1527
Query: 1129 EPTPMDEMSTPRDVMSDETNNEETESPSQEFVN--ITKYESSLYSQEYSKPADVTPLNGF 1186
+ P + + V+ N E + + +N T+ E + + K + V P
Sbjct: 1528 DKNPCKDRE--KHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDK-STVKPKPQL 1584
Query: 1187 SEGSK---------TDATDGKDYNASASTISPPSSMEEDKFSRSA-LRDAYCSEVKAS-- 1234
S S+ +A DYN S S + EE + S L+D + K S
Sbjct: 1585 SHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLD 1644
Query: 1235 TTLDIKDSISAVSSEKVSPSKSPSLSPSP 1263
T ++ IS S SPS SPS S SP
Sbjct: 1645 TAAVVQVGISRNQSHS-SPSVSPSRSHSP 1672
Score = 51.2 bits (121), Expect = 1e-05
Identities = 44/197 (22%), Positives = 88/197 (44%), Gaps = 8/197 (4%)
Query: 532 QTKLKQRADSRESLKPAAKPLPSKSVRKE-SKEETPEVTKVNHVEKPPKVESKEKVMVKK 590
+T++++ + + K KP P S S + T E + + +S+ V VK+
Sbjct: 1561 ETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKE 1620
Query: 591 DKP---IKTETKPSVTEKEVPSKEEPSPVKAEVAEKQA---TDVKPKAAKEKTVKKETKV 644
++ I + K + EK S + + V+ ++ Q+ V P + + +T+
Sbjct: 1621 EESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPS-GSQTRS 1679
Query: 645 KPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKET 704
+ + K+ KK++K KK +K KK + + E++K +K + KK+ K+
Sbjct: 1680 HSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKN 1739
Query: 705 PPKEVKKEVKKEEKKEV 721
KE +KE ++ K V
Sbjct: 1740 KDKEKEKEKDDQKVKSV 1756
Score = 43.9 bits (102), Expect = 0.002
Identities = 40/180 (22%), Positives = 75/180 (41%), Gaps = 6/180 (3%)
Query: 557 VRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPV 616
+ K + + P+++ + + E+ E +E+ SV E+E S +
Sbjct: 1573 IDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEE-SSGNISKDL 1631
Query: 617 KAEVAEKQATDVKPKAAKEKTVKK-ETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKP 675
K ++ EK + A + + + ++ P P + + E +
Sbjct: 1632 KDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQD 1691
Query: 676 KKEEVKKEVKKEIKKEEK-KEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKK 734
K KK+ KKE KK +K K+ KK K E++K K + KK+ K+ K+ +KE +K
Sbjct: 1692 SK---KKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEK 1748
Score = 43.5 bits (101), Expect = 0.003
Identities = 36/125 (28%), Positives = 59/125 (47%), Gaps = 8/125 (6%)
Query: 2212 PRHPDVSMVDPEALAIEQNLGKAL-KKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAA 2270
P D + V E + E K++ +KD +E+ K K G KTK +K+DG +
Sbjct: 944 PSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTK-----RKNDGSAVSKKE 998
Query: 2271 S-PKPAGLKESSDKVSRVASPKKKESVEKAAKPT-TTPEVKAARGEEKDKETKNAANASA 2328
+ KPA + R SP+ + ++KA + T T K++ +KD++ +
Sbjct: 999 NIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAH 1058
Query: 2329 SKSAK 2333
SKSAK
Sbjct: 1059 SKSAK 1063
Score = 38.5 bits (88), Expect = 0.083
Identities = 105/520 (20%), Positives = 179/520 (34%), Gaps = 114/520 (21%)
Query: 916 EKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDE 975
EK D +D E+ SE + K + GEE S +P E
Sbjct: 866 EKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEE----SEGFLNPELLE 921
Query: 976 ESAKAEADAYIREKRES----VASGDDRA---EEDMD-EAIE-KGEAEQSEEEADEEDKA 1026
S K+ + E + + S DD +E MD E+I K +E+ + E D+
Sbjct: 922 TSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAK 981
Query: 1027 EDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIH 1086
D + + + + ++ ++ E E + +SP EP
Sbjct: 982 GDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERE-------------RSPRSEPPIKKA 1028
Query: 1087 DETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDE 1146
E P +++ T S +++D+ T +++S E E P+ E +D D
Sbjct: 1029 KEETP---KTDNTKSSSSSQKDEKITGTPRKAHSKSAKE-HQETKPVKEEKVKKDYSKDV 1084
Query: 1147 TNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATD-GKDYNASAS 1205
+ + T TK E + E +KP D G KT+ KD+ +S+
Sbjct: 1085 KSEKLT----------TKEEKAKKPNEKNKPLDN---KGEKRKRKTEEKGVDKDFESSSM 1131
Query: 1206 TIS-----------PPSSMEED--KFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVS 1252
IS P ME D K R+ +D A K ++ + +K+
Sbjct: 1132 KISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAK-----KIKLNRETGKKIG 1186
Query: 1253 PSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCAS 1312
+++ S + P LE T S +V QE V+
Sbjct: 1187 STENISNTKEPSEKLEST---------------------------SSKVKQEKVKGKVR- 1218
Query: 1313 PEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDEN 1372
+ VTG+ G + T S+ PV S+ K +
Sbjct: 1219 ------------RKVTGTEGSSSTLVDYTSTSSTG----------GSPV--RKSEEKTDT 1254
Query: 1373 ERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYES 1412
+R + M+E D+ +P E V+ ++ P + +ES
Sbjct: 1255 KRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFES 1294
Score = 35.4 bits (80), Expect = 0.70
Identities = 59/267 (22%), Positives = 99/267 (37%), Gaps = 47/267 (17%)
Query: 555 KSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEP- 613
KS S++ P K + K P E+K V K+ P K K + + +KE
Sbjct: 1497 KSNSSPSRDRKPHDHKATYDTKRPNEETKS---VDKN-PCKDREKHVLEARN--NKESSG 1550
Query: 614 -------SPVKAEVAEKQATD------VKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEV 660
+P + +V ++Q T VKPK + + + + E + E P
Sbjct: 1551 NKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFE-PDYNE 1609
Query: 661 AKKEDKTPIKKEE------KPKKEEVKKEVKKEI-----------KKEEKKEPKKEVKKE 703
+ E +K+EE K K+++ ++ K+ + + + P +
Sbjct: 1610 SDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRS 1669
Query: 704 TPPK------EVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKP 757
P E + KK++K+ KK+ KK K K +E + + K
Sbjct: 1670 HSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKH 1729
Query: 758 KVPKKEESVKKDSVAAGKPKEKGKIKV 784
K KK+ KD K KEK KV
Sbjct: 1730 KHKKKKSKKNKDK---EKEKEKDDQKV 1753
Score = 33.1 bits (74), Expect = 3.5
Identities = 58/237 (24%), Positives = 79/237 (33%), Gaps = 28/237 (11%)
Query: 2091 KHPKTELSPSFINPNPLEWFA-SEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTS 2149
K K E S F+NP LE S EPT E P + D TP
Sbjct: 904 KRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPS---------RDDATPVRD 954
Query: 2150 VSESAPSQTDSDVPPETE---ECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQ 2206
A S T V + + + P D D S + V K P V
Sbjct: 955 EPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIV--KPAKGPQEKVD 1012
Query: 2207 -DRSPSPR-HPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGK 2264
+R SPR P + E + K + K GT K+ S K +
Sbjct: 1013 GERERSPRSEPPIKKAKEETPKTDNT-----KSSSSSQKDEKITGTPRKAHSKSAKEHQE 1067
Query: 2265 SKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETK 2321
+KP+ K D V S K EKA KP + +GE++ ++T+
Sbjct: 1068 TKPVKEE------KVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTE 1118
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 103 bits (258), Expect = 2e-21
Identities = 186/809 (22%), Positives = 318/809 (39%), Gaps = 126/809 (15%)
Query: 528 PVVKQTKLKQRADS--RESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVE-SKE 584
P + +T K R + E+ + LPS+ ++E + + K + ++
Sbjct: 951 PELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERD 1010
Query: 585 KVMVKKDKPIKTETKPSVTEKE---VPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKE 641
K K DK + +V++KE P+K V E ++ K AKE+T K +
Sbjct: 1011 KPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTD 1070
Query: 642 -TKVKPEDKKEEK--EKPKKEVAKKEDKTPIKKEEKPKKEE-VKKEVKKEIKKEEKKEPK 697
TK +K+EK P+K +K + +E KP KEE VKK+ K++K E K
Sbjct: 1071 NTKSSSSSQKDEKITGTPRKAHSKSAKE---HQETKPVKEEKVKKDYSKDVKSE--KLTT 1125
Query: 698 KEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPA---A 754
KE K + P ++ K K EK++ K EEK K+ + K S ++E KP+
Sbjct: 1126 KEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFES--SSMKISKLEVTEIVKPSPKRK 1183
Query: 755 LKPKVPKKEESVKKDSVAAGKPKEK-------------------------------GKIK 783
++P K + + +KD ++ P +K K+K
Sbjct: 1184 MEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVK 1243
Query: 784 VIKKEGKAAEAVAAAVGTGATT---AAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDF 840
K +GK V G+ +T + + G ++ + +R+++ + E+ D
Sbjct: 1244 QEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNND- 1302
Query: 841 EELKAEEVDVTKDIKPQLELIED-----EEKLKETEPVEAYVIQKEREVTKGPAESPDEG 895
AE+V + + PQ + +D EE +K T+P+ + + K V K + P
Sbjct: 1303 NTAPAEDVIIMIQV-PQSKWDKDDFESEEEDVKSTQPISS--VGKPASVIKNVSTKPSNI 1359
Query: 896 ITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPE 955
+ E +E EP EK I+KF + S E +E K+ A
Sbjct: 1360 VKYPE---------KESEPSEK-----IQKFTK-----DVSHEIIQHEVKSSKNSA---- 1396
Query: 956 EDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKG---E 1012
+S+ T+D + + E + EKR++ S E ++D E+G
Sbjct: 1397 ----------SSEKGKTKDRDYSVLEKEN--PEKRKN--STQPEKESNLDRLNEQGNFKS 1442
Query: 1013 AEQSEEEADEEDKAEDAR---EEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPT 1069
QS +EA DK + R +++ P + + DY + E +P+
Sbjct: 1443 LSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPS 1502
Query: 1070 KQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISS- 1128
+ + S + D G +S+ + S +R+ +P + AT + E S
Sbjct: 1503 RNKDSASGQKNKPREERDLPKKGTGDSKKSNS-SPSRDRKPHDHKATYDTKRPNEETKSV 1561
Query: 1129 EPTPMDEMSTPRDVMSDETNNEETESPSQEFVN--ITKYESSLYSQEYSKPADVTPLNGF 1186
+ P + + V+ N E + + +N T+ E + + K + V P
Sbjct: 1562 DKNPCKDRE--KHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDK-STVKPKPQL 1618
Query: 1187 SEGSK---------TDATDGKDYNASASTISPPSSMEEDKFSRSA-LRDAYCSEVKAS-- 1234
S S+ +A DYN S S + EE + S L+D + K S
Sbjct: 1619 SHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLD 1678
Query: 1235 TTLDIKDSISAVSSEKVSPSKSPSLSPSP 1263
T ++ IS S SPS SPS S SP
Sbjct: 1679 TAAVVQVGISRNQSHS-SPSVSPSRSHSP 1706
Score = 51.2 bits (121), Expect = 1e-05
Identities = 44/197 (22%), Positives = 88/197 (44%), Gaps = 8/197 (4%)
Query: 532 QTKLKQRADSRESLKPAAKPLPSKSVRKE-SKEETPEVTKVNHVEKPPKVESKEKVMVKK 590
+T++++ + + K KP P S S + T E + + +S+ V VK+
Sbjct: 1595 ETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKE 1654
Query: 591 DKP---IKTETKPSVTEKEVPSKEEPSPVKAEVAEKQA---TDVKPKAAKEKTVKKETKV 644
++ I + K + EK S + + V+ ++ Q+ V P + + +T+
Sbjct: 1655 EESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPS-GSQTRS 1713
Query: 645 KPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKET 704
+ + K+ KK++K KK +K KK + + E++K +K + KK+ K+
Sbjct: 1714 HSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKN 1773
Query: 705 PPKEVKKEVKKEEKKEV 721
KE +KE ++ K V
Sbjct: 1774 KDKEKEKEKDDQKVKSV 1790
Score = 43.9 bits (102), Expect = 0.002
Identities = 40/180 (22%), Positives = 75/180 (41%), Gaps = 6/180 (3%)
Query: 557 VRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPV 616
+ K + + P+++ + + E+ E +E+ SV E+E S +
Sbjct: 1607 IDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEE-SSGNISKDL 1665
Query: 617 KAEVAEKQATDVKPKAAKEKTVKK-ETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKP 675
K ++ EK + A + + + ++ P P + + E +
Sbjct: 1666 KDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQD 1725
Query: 676 KKEEVKKEVKKEIKKEEK-KEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKK 734
K KK+ KKE KK +K K+ KK K E++K K + KK+ K+ K+ +KE +K
Sbjct: 1726 SK---KKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEK 1782
Score = 43.5 bits (101), Expect = 0.003
Identities = 36/125 (28%), Positives = 59/125 (47%), Gaps = 8/125 (6%)
Query: 2212 PRHPDVSMVDPEALAIEQNLGKAL-KKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAA 2270
P D + V E + E K++ +KD +E+ K K G KTK +K+DG +
Sbjct: 978 PSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTK-----RKNDGSAVSKKE 1032
Query: 2271 S-PKPAGLKESSDKVSRVASPKKKESVEKAAKPT-TTPEVKAARGEEKDKETKNAANASA 2328
+ KPA + R SP+ + ++KA + T T K++ +KD++ +
Sbjct: 1033 NIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAH 1092
Query: 2329 SKSAK 2333
SKSAK
Sbjct: 1093 SKSAK 1097
Score = 38.5 bits (88), Expect = 0.083
Identities = 105/520 (20%), Positives = 179/520 (34%), Gaps = 114/520 (21%)
Query: 916 EKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDE 975
EK D +D E+ SE + K + GEE S +P E
Sbjct: 900 EKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEE----SEGFLNPELLE 955
Query: 976 ESAKAEADAYIREKRES----VASGDDRA---EEDMD-EAIE-KGEAEQSEEEADEEDKA 1026
S K+ + E + + S DD +E MD E+I K +E+ + E D+
Sbjct: 956 TSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAK 1015
Query: 1027 EDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIH 1086
D + + + + ++ ++ E E + +SP EP
Sbjct: 1016 GDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERE-------------RSPRSEPPIKKA 1062
Query: 1087 DETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDE 1146
E P +++ T S +++D+ T +++S E E P+ E +D D
Sbjct: 1063 KEETP---KTDNTKSSSSSQKDEKITGTPRKAHSKSAKE-HQETKPVKEEKVKKDYSKDV 1118
Query: 1147 TNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATD-GKDYNASAS 1205
+ + T TK E + E +KP D G KT+ KD+ +S+
Sbjct: 1119 KSEKLT----------TKEEKAKKPNEKNKPLDN---KGEKRKRKTEEKGVDKDFESSSM 1165
Query: 1206 TIS-----------PPSSMEED--KFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVS 1252
IS P ME D K R+ +D A K ++ + +K+
Sbjct: 1166 KISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAK-----KIKLNRETGKKIG 1220
Query: 1253 PSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCAS 1312
+++ S + P LE T S +V QE V+
Sbjct: 1221 STENISNTKEPSEKLEST---------------------------SSKVKQEKVKGKVR- 1252
Query: 1313 PEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDEN 1372
+ VTG+ G + T S+ PV S+ K +
Sbjct: 1253 ------------RKVTGTEGSSSTLVDYTSTSSTG----------GSPV--RKSEEKTDT 1288
Query: 1373 ERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYES 1412
+R + M+E D+ +P E V+ ++ P + +ES
Sbjct: 1289 KRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFES 1328
Score = 35.4 bits (80), Expect = 0.70
Identities = 59/267 (22%), Positives = 99/267 (37%), Gaps = 47/267 (17%)
Query: 555 KSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEP- 613
KS S++ P K + K P E+K V K+ P K K + + +KE
Sbjct: 1531 KSNSSPSRDRKPHDHKATYDTKRPNEETKS---VDKN-PCKDREKHVLEARN--NKESSG 1584
Query: 614 -------SPVKAEVAEKQATD------VKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEV 660
+P + +V ++Q T VKPK + + + + E + E P
Sbjct: 1585 NKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFE-PDYNE 1643
Query: 661 AKKEDKTPIKKEE------KPKKEEVKKEVKKEI-----------KKEEKKEPKKEVKKE 703
+ E +K+EE K K+++ ++ K+ + + + P +
Sbjct: 1644 SDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRS 1703
Query: 704 TPPK------EVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKP 757
P E + KK++K+ KK+ KK K K +E + + K
Sbjct: 1704 HSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKH 1763
Query: 758 KVPKKEESVKKDSVAAGKPKEKGKIKV 784
K KK+ KD K KEK KV
Sbjct: 1764 KHKKKKSKKNKDK---EKEKEKDDQKV 1787
Score = 33.1 bits (74), Expect = 3.5
Identities = 58/237 (24%), Positives = 79/237 (33%), Gaps = 28/237 (11%)
Query: 2091 KHPKTELSPSFINPNPLEWFA-SEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTS 2149
K K E S F+NP LE S EPT E P + D TP
Sbjct: 938 KRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPS---------RDDATPVRD 988
Query: 2150 VSESAPSQTDSDVPPETE---ECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQ 2206
A S T V + + + P D D S + V K P V
Sbjct: 989 EPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIV--KPAKGPQEKVD 1046
Query: 2207 -DRSPSPR-HPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGK 2264
+R SPR P + E + K + K GT K+ S K +
Sbjct: 1047 GERERSPRSEPPIKKAKEETPKTDNT-----KSSSSSQKDEKITGTPRKAHSKSAKEHQE 1101
Query: 2265 SKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETK 2321
+KP+ K D V S K EKA KP + +GE++ ++T+
Sbjct: 1102 TKPVKEE------KVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTE 1152
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 103 bits (256), Expect = 3e-21
Identities = 138/578 (23%), Positives = 237/578 (41%), Gaps = 100/578 (17%)
Query: 523 GQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVES 582
G++ P +++ ++ + D E + + + +K KE KE+ E KV EKP K +
Sbjct: 131 GEIDEPPLRKKEIHK--DKTEKQEKPERKIQTKVTHKE-KEKGKE--KVREKEKPEKKAT 185
Query: 583 KEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKET 642
++ + KK+KP +T+T +K +++ K EV + VK AAK K V+K T
Sbjct: 186 HKEKIEKKEKP-ETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQK-T 243
Query: 643 KVKPEDKKEEKEK---------------------------------------PKKEVAKK 663
KP++ KE+KEK P ++ ++
Sbjct: 244 PSKPKE-KEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRP 302
Query: 664 EDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKK--EEKKEV 721
+P +E++ +K++ +K+V E KK+EK++ KK+ +KET KKE K E K+
Sbjct: 303 TPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGT 362
Query: 722 KK--EEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEK 779
K + KK+ KK +D+KK+ KKPA ++ KK+E +K A PK++
Sbjct: 363 VKIAAQAAAKKDEKK--EDSKKT-------KKPAEVEQPKGKKQEKKEKHVEPAKSPKKE 413
Query: 780 GKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKD 839
+ K+ E +G + AV E E + + KD
Sbjct: 414 HSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKE-EKTTKTVEQEIRKEKSGKTSSILKD 472
Query: 840 FEELKAEEVDVTKDIKPQLELIEDEEKL----KETEPVEAYVIQKEREVTKGPAESPDEG 895
E +K +E V +K + + +EK+ KE +P K ++ E P+
Sbjct: 473 KEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKP-------KPPQLQGKKEEKPEPQ 525
Query: 896 ITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPE 955
I + E + E + KQ + EK G E+ + + KA T E
Sbjct: 526 I-----KKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLK----QVKAVTIE----- 571
Query: 956 EDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQ 1015
+K PT+ E + E + +K + G E K + E
Sbjct: 572 ---------KTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTES-----GKKKTEI 617
Query: 1016 SEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAA 1053
SE+E+ E+ + REE+ K + + + +K A
Sbjct: 618 SEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPA 655
Score = 96.7 bits (239), Expect = 3e-19
Identities = 150/600 (25%), Positives = 238/600 (39%), Gaps = 95/600 (15%)
Query: 505 LKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEE 564
L+ + K Q+ ++ T V + K K + RE KP K + + K+ K E
Sbjct: 138 LRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPE 197
Query: 565 TPEVTKVNHVEKPP-KVESKEKVMVKKDKPIK-------------TETKPSVTE---KEV 607
T + K K K E K K VK K K T +KP E K
Sbjct: 198 TKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAA 257
Query: 608 PSKEE----------------------------PSPVKAEVAEKQATDVKPKAAKEKTVK 639
SK E P P+ E A + KE K
Sbjct: 258 VSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKK 317
Query: 640 K-ETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKK-----EIKKEEK 693
K E KV E KK+EKE KK+ ++KE ++K+E K E K+ K KK+EK
Sbjct: 318 KAEKKVTSETKKKEKEDIKKK-SEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEK 376
Query: 694 KEPKKEVKKETPPKEVKK-EVKKEEKKEVKKE-EKEPKKEIKKLPKD--AKKSSTPLSEA 749
KE K+ KK P EV++ + KK+EKKE E K PKKE +P D K + E
Sbjct: 377 KEDSKKTKK---PAEVEQPKGKKQEKKEKHVEPAKSPKKE-HSVPSDKQVKAKTERAKEE 432
Query: 750 KKPAALKPKVP-KKEESVKKDSVAAGKPKEKGKIKVIKKE-----GKAAEAVAAAVGTGA 803
++K VP KKEE K + ++ GK I K+ GK + A+
Sbjct: 433 IGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEP 492
Query: 804 TTA--AVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKD--IKPQLE 859
T M+ AG +L+ ++ P+ + K+ + +E+V + K +KP+
Sbjct: 493 ETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQ-IKKEAKPAISEKVQIHKQDIVKPEKT 551
Query: 860 LIEDEEKLKETEPVEAYVIQK----------EREVTKGPAESPDEGITTTEGEGECEQTP 909
+ + + K + V+A I+K E + P+ D+ T +G E ++
Sbjct: 552 VSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESG 611
Query: 910 EELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKH 969
++ + ++ + EK + + E+ S + + +AE+P ++ V ASK
Sbjct: 612 KKKTEISEK--ESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKK 669
Query: 970 SP--TEDEESAKAEA----------DAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSE 1017
+ TED K ++ D Y + + DR E +A G+ +Q +
Sbjct: 670 AKEGTEDVSPTKQKSPISFFQCVYLDGYNGYGFQFPFTPADRPGESSGQANSPGQKQQGQ 729
Score = 87.8 bits (216), Expect = 1e-16
Identities = 145/641 (22%), Positives = 248/641 (38%), Gaps = 77/641 (12%)
Query: 607 VPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDK 666
+ S++E E +K D P KE +DK E++EKP++++ +
Sbjct: 114 ISSEDEEDDDGDEDTDKGEIDEPPLRKKEIH---------KDKTEKQEKPERKI-----Q 159
Query: 667 TPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETP-PKEVKKEVKKEEKKEVKKEE 725
T + +EK K +E +E +K KK KE K KKE P K + KE KK K +K E
Sbjct: 160 TKVTHKEKEKGKEKVREKEKPEKKATHKE--KIEKKEKPETKTLAKEQKK--AKTAEKSE 215
Query: 726 KEPKKEIKKLPKD-AKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKV 784
++ KKE+K ++ K+++ + E +K P PK++E +K K V
Sbjct: 216 EKTKKEVKGGKQEKVKQTAAKVKEVQK----TPSKPKEKE-------------DKEKAAV 258
Query: 785 IKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELK 844
K E K A + + A P +A R +SP K+ E+ K
Sbjct: 259 SKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKK 318
Query: 845 AEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGE 904
AE+ ++ K + E I+ + + + VE K E +G + + + + E
Sbjct: 319 AEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKE 378
Query: 905 CE---QTPEELEPVEKQGVDDIEK-FEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEE 960
+ P E+E + + + EK E + +E S D + KA+TE A+ EE
Sbjct: 379 DSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAK------EE 432
Query: 961 HVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEA 1020
VS K P + EE + IR+++ S + +E + EK A E+E
Sbjct: 433 IGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEP 492
Query: 1021 D---EEDKAEDAREEEYEPEKMEA--EDYVMAVVDKAAEAGGAEE---QYGFLTTPTKQL 1072
+ +E ++ +E + +P +++ E+ + K A+ +E+ + P K +
Sbjct: 493 ETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTV 552
Query: 1073 GAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFT----ATSGYTQSTIEISS 1128
P + + T+ ++ + T E + P T T T E
Sbjct: 553 SHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGK 612
Query: 1129 EPTPMDEMSTPRDVMSDETNNEE--TESPSQEFVNITKYESSLYSQEYSKPADVTPLNGF 1186
+ T + E + E+ T S + N+TK E KPA V+
Sbjct: 613 KKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAE---------KPARVSK---- 659
Query: 1187 SEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAY 1227
D K +SP F + D Y
Sbjct: 660 ---DVEDVPASKKAKEGTEDVSPTKQKSPISFFQCVYLDGY 697
Score = 51.2 bits (121), Expect = 1e-05
Identities = 37/132 (28%), Positives = 61/132 (46%), Gaps = 12/132 (9%)
Query: 2200 PPPAPVQDRS-PSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPV 2258
PPP P + S P+P P + + E E+ + KK KEK KK K +
Sbjct: 291 PPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKK--KEKEDIKKKSEKETAIDVE 348
Query: 2259 KKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDK 2318
KK GK+ + K+ + K++ A+ KK E E + K EV+ +G++++K
Sbjct: 349 KKEPGKA---------SETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEK 399
Query: 2319 ETKNAANASASK 2330
+ K+ A + K
Sbjct: 400 KEKHVEPAKSPK 411
Score = 42.0 bits (97), Expect = 0.007
Identities = 51/253 (20%), Positives = 91/253 (35%), Gaps = 30/253 (11%)
Query: 2111 ASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECP 2170
A ++ +E K + P G KQ+ ++ P S + +D V +TE
Sbjct: 371 AKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTER-- 428
Query: 2171 SITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQN 2230
+++E + K V K + V+ + S + + I
Sbjct: 429 ---------AKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPI--- 476
Query: 2231 LGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKES--SDKVSRVA 2288
K ++ + K K+P +TK + K+ + KP P+ G KE ++ + A
Sbjct: 477 --KGKEEKVPASLKEKEP--ETKKDEKMSKAGKEVKP--KPPQLQGKKEEKPEPQIKKEA 530
Query: 2289 SPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATA--------GPG 2340
P E V+ + PE + G+ ++K K + K+AK P
Sbjct: 531 KPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPP 590
Query: 2341 TTKTTKSSAVPPG 2353
+ KT K P G
Sbjct: 591 SIKTDKPKPTPKG 603
Score = 39.7 bits (91), Expect = 0.037
Identities = 49/190 (25%), Positives = 76/190 (40%), Gaps = 25/190 (13%)
Query: 2179 DSEDESETIPTDKTVTYKHMDPPPAPVQ----DRSPSPRHPDVSMVDPEALAIEQNLGKA 2234
D ED+ TDK +D PP + D++ P+ + + E+ GK
Sbjct: 118 DEEDDDGDEDTDKG----EIDEPPLRKKEIHKDKTEKQEKPE-RKIQTKVTHKEKEKGK- 171
Query: 2235 LKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKE-SSDKVSRVASPKKK 2293
+ ++EK K +K T + KK ++K LA K A E S +K + K+
Sbjct: 172 --EKVREKEKPEKKATHKEKIE--KKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQ 227
Query: 2294 ESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTAT--------AGPGTTKTT 2345
E V++ A EV+ + K+KE K A S + G K
Sbjct: 228 EKVKQTA--AKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPG 285
Query: 2346 KSSAVPPGLP 2355
+S A+PP LP
Sbjct: 286 QSPAIPPPLP 295
Score = 38.1 bits (87), Expect = 0.11
Identities = 53/212 (25%), Positives = 77/212 (36%), Gaps = 38/212 (17%)
Query: 2181 EDESETIPTDK-TVTYKHMDPPPAPVQDRSPSPRHPDVS-----------------MVDP 2222
E E ET +K + K + P P +Q + P + +V P
Sbjct: 489 EKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKP 548
Query: 2223 EALAI----EQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLK 2278
E E+ + K +K EKT KP K + S KP P P G
Sbjct: 549 EKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKP---KPTPKGTS 605
Query: 2279 ESSDKVSRVASPKKKESVEKA-------AKPTTTPEV----KAARGEEKDKETKNAANAS 2327
E ++ + +KES EKA K +T E + E+ + +K+ +
Sbjct: 606 EVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVP 665
Query: 2328 ASKSAKTATAGPGTTKTTKSSAVPPGLPVYLD 2359
ASK AK T TK + S + VYLD
Sbjct: 666 ASKKAKEGTEDVSPTK--QKSPISFFQCVYLD 695
Score = 37.0 bits (84), Expect = 0.24
Identities = 58/245 (23%), Positives = 89/245 (36%), Gaps = 23/245 (9%)
Query: 2125 QSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDES 2184
QS PPP +Q R +P E + + V ET++ +I + E
Sbjct: 286 QSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKK----KEKEDIKKKSEK 341
Query: 2185 ET-IPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVD----PEALAIEQNLGKALKKDL 2239
ET I +K K + V+ + + D D + +EQ GK +K
Sbjct: 342 ETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKE 401
Query: 2240 K--EKTKTKKPGTKTKSSSPVKKSDGKSKPL--AASPKPAGLKESSDKVSRVASPK---- 2291
K E K+ K S VK ++K A S K A + +K ++ +
Sbjct: 402 KHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKE 461
Query: 2292 ---KKESVEKAAKPTTTPEVKA-ARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKS 2347
K S+ K +P E K A +EK+ ETK + SK+ K P + K
Sbjct: 462 KSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKK--DEKMSKAGKEVKPKPPQLQGKKE 519
Query: 2348 SAVPP 2352
P
Sbjct: 520 EKPEP 524
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 102 bits (254), Expect = 5e-21
Identities = 119/549 (21%), Positives = 261/549 (47%), Gaps = 56/549 (10%)
Query: 511 LKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTK 570
LK+ L K L QV T +++ +Q + RE K K K R+E + E K
Sbjct: 213 LKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQ-EEKMWRQEERLREQE-GK 270
Query: 571 VNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKP 630
+ E+ K+ +EK + +++K ++ + K +K++ +EE + E +Q + K
Sbjct: 271 MREQEE--KMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQ--EEKM 326
Query: 631 KAAKEKTVKKETKVKPEDK----KEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKK 686
+ +EK ++E ++ ++K +E+K + ++E ++D+ +KEE+ +++E E ++
Sbjct: 327 REQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEE 386
Query: 687 EIKKEE--KKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSST 744
++++EE ++ KK ++E +E +++++K+E+ ++EEKE +++ +LP+ +K
Sbjct: 387 KMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ--RLPEQKEK--- 441
Query: 745 PLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGK-IKVIKKEGKAAEAVAAAVGTGA 803
L E +K + K+ ++EE ++ G+ K+ + K+ ++E + E
Sbjct: 442 -LWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ--------- 491
Query: 804 TTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIED 863
K + E+ + E + + E L+ +E + ++ Q ++ +
Sbjct: 492 ---------------EEKMRDQEQKMWDQEERMWEQDERLREKE----ERMREQKKMWQQ 532
Query: 864 EEKLKE---TEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGV 920
EEK++E T+ E +E ++ + E E E EQ + E EK
Sbjct: 533 EEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMRE 592
Query: 921 DDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKA 980
+ + +E E E+ + + EEK +E E+ ++ EE + K +++E
Sbjct: 593 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEK---MQEQEEKMW 649
Query: 981 EADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEE--ADEEDKAEDAREEEY-EPE 1037
E + +RE+ E + +++ + ++ E+ E Q +EE ++E+K E+ + + E
Sbjct: 650 EQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEE 709
Query: 1038 KMEAEDYVM 1046
KM ++ M
Sbjct: 710 KMWGQEEKM 718
Score = 73.6 bits (179), Expect = 2e-12
Identities = 118/604 (19%), Positives = 260/604 (43%), Gaps = 55/604 (9%)
Query: 589 KKDKPIKTETKPSVTEK-EVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPE 647
KK+ ++ + + + +EK E+ + K E A+ V+ +E+ ++E +++ +
Sbjct: 187 KKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQ 246
Query: 648 DKKEEKEKPK----KEVAKKEDKTPIKKEEKPKKEEVK-KEVKKEIKKEEK--KEPKKEV 700
+KK K++ K +E ++++ ++EEK +++E + +E +KE++++EK +E KK
Sbjct: 247 EKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLR 306
Query: 701 KKETPPKEVKKEVKKEEKKEVKKEEK---------EPKKEIKKLPKDAKKSSTPLSEAKK 751
++E +E ++++ ++E+K ++EEK E +K++++ + + + E +
Sbjct: 307 EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDE 366
Query: 752 PAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAA 811
K + +++E + + K +E+ +I+ +K+ + E T
Sbjct: 367 RLREKEERMREQEKMWEQEE---KMQEEERIREREKKMREEEE---------TMREQEEK 414
Query: 812 AGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVT-----KDIKPQLELIEDEEK 866
++ E E PE K +E+ K +E + + I+ Q E+ E+K
Sbjct: 415 MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKK 474
Query: 867 LKETEPV---EAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDI 923
+ E + E + ++E ++ + D+ E + + E + +K +
Sbjct: 475 MWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQE- 533
Query: 924 EKFEDEGAGFEESSETGDYEEKAETEEA-EEPEEDGEEHVCVSASKHSPTEDEESAKAEA 982
EK +E E+ +T D EEK EE E E+ E + + +++E E
Sbjct: 534 EKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQ 593
Query: 983 DAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDK---AEDAREEEYEPEKM 1039
+ + E+ E + EE M E EK ++ E++ E+++ ++ + +E E +
Sbjct: 594 EEKMWEQEEKM----QEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMW 649
Query: 1040 EAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEAT 1099
E E+ + +K E EE+ ++ + G+E +E + G + E
Sbjct: 650 EQEEKMREQEEKMRE---QEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRG--QEEKM 704
Query: 1100 ASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEF 1159
EE Q E+ + I + M E R +E +E PS+
Sbjct: 705 WGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQE----RLPEHEERCSEPCLPPSKVL 760
Query: 1160 VNIT 1163
N++
Sbjct: 761 CNMS 764
Score = 70.9 bits (172), Expect = 2e-11
Identities = 98/547 (17%), Positives = 232/547 (42%), Gaps = 64/547 (11%)
Query: 601 SVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETK-----VKPEDKKEEKEK 655
++T +E+ K K +AE + ++++ + K + K V+ +EE +
Sbjct: 179 TITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWR 238
Query: 656 PKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVK- 714
++E+ ++E K ++E+ ++EE +E + +++++E+K ++E + KE++++ K
Sbjct: 239 QEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKE 298
Query: 715 -KEEKKEVKKEEKEPKKEIKKLPKDAK----------KSSTPLSEAKKPAALKPKVPKKE 763
+E+KK ++EE+ ++E K ++ K + + K+ + K+ +E
Sbjct: 299 LREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQE 358
Query: 764 ESV--KKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAK 821
E + + + + + + + + K+ ++E K E +
Sbjct: 359 ERMWEQDERLREKEERMREQEKMWEQEEKMQE-------------------------EER 393
Query: 822 ELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIK---PQLELIEDEEKLKETEPVEAY-- 876
E E+ + E + + E+++ +E ++ + + Q L E +EKL E E ++
Sbjct: 394 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE 453
Query: 877 VIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEES 936
I ++ E + E + E EQ + E EK + + ++ E +E+
Sbjct: 454 KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQD 513
Query: 937 SETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTED------EESAKAEADAYIREKR 990
+ EE+ ++ +E+ + + T D EE E + +RE+
Sbjct: 514 ERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE 573
Query: 991 ESVASGDDRAEEDMDEAIEKGEA--EQSEEEADEEDKAEDARE---EEYEPEKMEAEDYV 1045
E + +++ +E ++ E+ E EQ E+ ++E+K + E E+ E +KM+ ++ +
Sbjct: 574 EMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEM 633
Query: 1046 MAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEEN 1105
M ++ + E++ K + RE + + + E EE
Sbjct: 634 MWEQEEKMQ----EQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEK 689
Query: 1106 REDQPEE 1112
+Q E+
Sbjct: 690 MREQEEK 696
Score = 66.2 bits (160), Expect = 4e-10
Identities = 97/520 (18%), Positives = 229/520 (44%), Gaps = 64/520 (12%)
Query: 536 KQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIK 595
K+ + + L+ K L + +E +E+ E + ++ E +EK+ ++++ +
Sbjct: 283 KRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE 342
Query: 596 TETKPSVTEKEVPSKEE---PSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKK-- 650
E + E+++ +EE + E++ + + +E+ +++E +++ +KK
Sbjct: 343 QEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMR 402
Query: 651 --EEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKE 708
EE + ++E +K+++ ++EEK +++ E K+++ ++EK + ++E E K
Sbjct: 403 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 462
Query: 709 VKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKK 768
+E ++K++ ++EK ++E + ++ K + +K + ++ +++E +++
Sbjct: 463 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMR----DQEQKMWDQEERMWEQDERLRE 518
Query: 769 DSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERS 828
+ K K+ ++E K E K+ + +
Sbjct: 519 KEERMREQK-----KMWQQEEKMRE--------------------------EKKTQEQEK 547
Query: 829 LMSSPEDLTKDFEELKAEEVDVTKDIKPQLELI-EDEEKLKETEPVEAYVIQKEREVTKG 887
E+ ++ E ++ E K ++ + E++ E EEK++E E +K RE +
Sbjct: 548 KTWDQEEKMREEERMRERE----KKMREEEEMMREQEEKMQEQE-------EKMREQEEK 596
Query: 888 PAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAE 947
E ++ E E E+ E E +K + +E E E+ + + EEK
Sbjct: 597 MWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMR 656
Query: 948 TEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDR---AEEDM 1004
+E + E++ + + + E EE + + + +RE+ E + +++ EE M
Sbjct: 657 EQEEKMREQEEK----MQGQEEKMREQEEKMQGQEEK-MREQEEKMRGQEEKMWGQEEKM 711
Query: 1005 DEAIEK--GEAEQSEEEADEEDKAEDAREEEYEPEKMEAE 1042
EK G+ E E+E D+ E +E E E+ +E
Sbjct: 712 WGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSE 751
Score = 61.6 bits (148), Expect = 9e-09
Identities = 63/338 (18%), Positives = 170/338 (50%), Gaps = 24/338 (7%)
Query: 512 KQPLATQKDLTGQVPTPVVKQTKLKQRADS----RESLKPAAKPLPSKSVR--------K 559
++ + Q+++ GQ + +Q K++++ D E ++ + + + R +
Sbjct: 459 EEKIRDQEEMWGQ-EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLR 517
Query: 560 ESKEETPEVTKVNHVEKPPKVESKEKVMVKK--DKPIKTETKPSVTEKEVPSKEEPSPVK 617
E +E E K+ E+ + E K + KK D+ K + + E+E +EE ++
Sbjct: 518 EKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 577
Query: 618 AEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKK 677
+ + Q + K + +EK ++E K++ +++K +++ K ++EDK ++E ++
Sbjct: 578 EQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQ 637
Query: 678 EEVKKEVKKEIKKEEKK--EPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKL 735
EE +E ++++ ++E+K E +++++++ + ++E +E++++++ +E++ +++ +K+
Sbjct: 638 EEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKM 697
Query: 736 PKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAV 795
+K + +K + K+ +EE +K+ + KEK + ++ + E + +E
Sbjct: 698 RGQEEKM---WGQEEKMWGQEEKMWGQEEMREKEERIRDQ-KEKMQERLPEHEERCSEPC 753
Query: 796 ---AAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLM 830
+ + + T +V A G A G ++ + +M
Sbjct: 754 LPPSKVLCNMSHTGSVEPAGGEAGEGSPQDNPTAQEIM 791
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo
sapiens]
Length = 916
Score = 99.4 bits (246), Expect = 4e-20
Identities = 123/519 (23%), Positives = 222/519 (42%), Gaps = 86/519 (16%)
Query: 529 VVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMV 588
++++TK++ E A + S+++E KE EK + E++E+ +
Sbjct: 456 IIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAE--------EKEEEPEAEEEEVA 507
Query: 589 KKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPK---AAKEKTVKKETKVK 645
K P+K T P V E+E +EE + E ++ A + + + KE + +KE +
Sbjct: 508 AKKSPVKA-TAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQ 566
Query: 646 PEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKE--PKKEVKKE 703
E + E + + ++ AK+E K K EE KEE+ + K E K E+ K PK V+++
Sbjct: 567 EEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVE-KPEKAKSPVPKSPVEEK 625
Query: 704 TPPKEVKKEVKKEEKKEVKKE--EKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPK 761
K V+++ K V K E++ K + K P + +K +P+S++ K VPK
Sbjct: 626 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE-EKGKSPVSKSPVEEKAKSPVPK 684
Query: 762 K--EESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGP 819
EE+ K V G+ KE+ + +V KE E V
Sbjct: 685 SPVEEAKSKAEVGKGEQKEEEEKEV--KEAPKEEKV------------------------ 718
Query: 820 AKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQ 879
K+ E + + + + EE AE V +TK +K LE +E +E +P++ +
Sbjct: 719 EKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLE----KETKEEGKPLQQ---E 771
Query: 880 KEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSET 939
KE+E G S +EG + +G +G+ E+ +
Sbjct: 772 KEKEKAGGEGGSEEEG--SDKGA--------------------------KGSRKEDIAVN 803
Query: 940 GDYEEKAETEEAEEPEEDGEEH---VCVSASKHSPTEDEESA-KAEADAYIREKRESVAS 995
G+ E K E E+ + + G E V + SP ++++ K+E + + E + S
Sbjct: 804 GEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITS 863
Query: 996 -GDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEE 1033
G D A + + +++ + + EE EE + E+
Sbjct: 864 EGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEK 902
Score = 79.7 bits (195), Expect = 3e-14
Identities = 125/550 (22%), Positives = 215/550 (39%), Gaps = 83/550 (15%)
Query: 617 KAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPK 676
K + + +A +K + + + +ETKV ED+K E E+ + + E +K+E+K
Sbjct: 435 KIQKPKVEAPKLKVQHKFVEEIIEETKV--EDEKSEMEEALTAITE-ELAVSMKEEKKEA 491
Query: 677 KEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLP 736
EE KE + E ++EE K VK P EVK+E ++E++E ++EE+E
Sbjct: 492 AEE--KEEEPEAEEEEVAAKKSPVKATAP--EVKEEEGEKEEEEGQEEEEE--------- 538
Query: 737 KDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVA 796
++E K D G +++G + K+EG+ E
Sbjct: 539 -------------------------EDEGAKSDQAEEGGSEKEGSSE--KEEGEQEEGET 571
Query: 797 AAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKP 856
A G A K++E + +++ E+L D K E+ + K P
Sbjct: 572 EAEAEGEEAEA----------KEEKKVEEKSEEVATKEELVAD---AKVEKPEKAKSPVP 618
Query: 857 QLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVE 916
+ + EEK K P + + V K P E + E ++P PVE
Sbjct: 619 KSPV---EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE 675
Query: 917 KQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEE 976
++ + K E A + G+ +E+ E E E P+E+ V + P + E
Sbjct: 676 EKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEK-----VEKKEEKPKDVPE 730
Query: 977 SAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEP 1036
KAE+ E V E E+G+ Q E+E ++ + EE +
Sbjct: 731 KKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK 790
Query: 1037 EKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSES 1096
+ +AV E G EE + TK+ G+ GRE + L
Sbjct: 791 GAKGSRKEDIAV---NGEVEGKEE----VEQETKEKGS---GREEEKGVVTNGL------ 834
Query: 1097 EATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPS 1156
+ + +DE+ D+ EE T++ +I+SE + V + E E+
Sbjct: 835 DLSPADEKKGGDKSEEKVVV---TKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFE 891
Query: 1157 QEFVNITKYE 1166
++ V+ K E
Sbjct: 892 EKLVSTKKVE 901
Score = 57.4 bits (137), Expect = 2e-07
Identities = 163/863 (18%), Positives = 297/863 (34%), Gaps = 171/863 (19%)
Query: 648 DKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPK 707
D K + K+++ D+ E+ E+ KE++ EI+ +K+ + +
Sbjct: 93 DYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQ 152
Query: 708 EVKK-----EVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKK 762
E+++ E+ EK +V+ + +++I +L + ++ A L+
Sbjct: 153 EIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKE----------RFEEEARLRDDTEAA 202
Query: 763 EESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKE 822
+++KD A K +++ KK + VA A + A A
Sbjct: 203 IRALRKDIEEASLVK----VELDKKVQSLQDEVAFLRSNHEEEVADLLAQI-----QASH 253
Query: 823 LEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEE--------KLKETEPVE 874
+ ER KD+ LK + K+I+ QLE D+ K + + E
Sbjct: 254 ITVER----------KDY--LKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTE 301
Query: 875 AYVIQKE------REVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFED 928
A KE E+ + + + I G E +L +E++ D+ ++D
Sbjct: 302 AAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQD 361
Query: 929 ---------EGAGFEESSETGDYEEKAETEEAEEPEE-------DGEEH----------- 961
G +E + +Y++ + A + E +GEE
Sbjct: 362 TIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITG 421
Query: 962 --------VCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEA 1013
+ +S+ P + K + ++ E E D+++E M+EA+
Sbjct: 422 PLYTHRPPITISSKIQKPKVEAPKLKVQ-HKFVEEIIEETKVEDEKSE--MEEALTAITE 478
Query: 1014 EQSEEEADEEDKAEDAREEEYEPEKMEA---EDYVMAVVDKAAEAGGAEEQYGFLTTPTK 1070
E + +E+ +A + +EEE E E+ E + V A + E G +E+
Sbjct: 479 ELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEE--------- 529
Query: 1071 QLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEP 1130
+ G + E + D+ GGSE E ++ EE +++ E G E
Sbjct: 530 EEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVE 589
Query: 1131 TPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGS 1190
+E++T ++++D + E P + + K S K P + E
Sbjct: 590 EKSEEVATKEELVADA----KVEKPEKAKSPVPK------SPVEEKGKSPVPKSPVEEKG 639
Query: 1191 KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEK 1250
K+ P S E+K + S V +
Sbjct: 640 KSPV---------------PKSPVEEKGKSPVPK-------------------SPVEEKG 665
Query: 1251 VSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHC 1310
SP + SP+ K+P+ E + E K E EV E E EE
Sbjct: 666 KSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP 725
Query: 1311 AS-PEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAK 1369
PE K E ++V + T KS + E K P+ E K
Sbjct: 726 KDVPEKKKAESPVKEEAVA---------EVVTITKSVKVHLEKETKEEGKPLQQE----K 772
Query: 1370 DENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAE--- 1426
++ + +E D + + + + G E + +K SGR E
Sbjct: 773 EKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQ---ETKEKGSGREEEKGV 829
Query: 1427 -------SPFEEKSGKQGSPDQV 1442
SP +EK G S ++V
Sbjct: 830 VTNGLDLSPADEKKGGDKSEEKV 852
Score = 57.4 bits (137), Expect = 2e-07
Identities = 60/242 (24%), Positives = 101/242 (41%), Gaps = 32/242 (13%)
Query: 2113 EEPTEESEKPLTQSGGAPPPPGG-KQQGRQCD-ETPPTSVSESAPSQTDSDVPPETEECP 2170
EE E ++ + GG+ K++G Q + ET + E A ++ + V ++EE
Sbjct: 537 EEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVA 596
Query: 2171 S---ITADANIDSEDESETIPTDKTVTYKHMDP-PPAPVQDR--SPSPRHPDVSMVDPEA 2224
+ + ADA ++ +++++ V K P P +PV+++ SP P+ P
Sbjct: 597 TKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSP--------- 647
Query: 2225 LAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKV 2284
+E+ K K+ K + K SPV KS + K A SP P E +
Sbjct: 648 --VEE----------KGKSPVPKSPVEEKGKSPVSKSPVEEK--AKSPVPKSPVEEAKSK 693
Query: 2285 SRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKT 2344
+ V ++KE EK K E K + EEK K+ A + + TK+
Sbjct: 694 AEVGKGEQKEEEEKEVKEAPKEE-KVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKS 752
Query: 2345 TK 2346
K
Sbjct: 753 VK 754
Score = 33.5 bits (75), Expect = 2.7
Identities = 40/209 (19%), Positives = 80/209 (38%), Gaps = 8/209 (3%)
Query: 2115 PTEESEKPLTQSGGAPPP----PGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECP 2170
P P+T S P P K Q + +E + E S+ + + TEE
Sbjct: 422 PLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELA 481
Query: 2171 SITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQN 2230
+ ++ +E E P + + + +PV+ +P + + + E E+
Sbjct: 482 VSMKEEKKEAAEEKEEEPEAEE---EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEE 538
Query: 2231 LGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASP 2290
+ K D E+ ++K G+ K ++ + +++ + K+ +K VA+
Sbjct: 539 EDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATK 598
Query: 2291 KKKESVEKAAKPTTTPE-VKAARGEEKDK 2318
++ + K KP V + EEK K
Sbjct: 599 EELVADAKVEKPEKAKSPVPKSPVEEKGK 627
Score = 33.1 bits (74), Expect = 3.5
Identities = 64/297 (21%), Positives = 102/297 (34%), Gaps = 41/297 (13%)
Query: 2093 PKTELSPSFINPNPLEWFASEEPTEESEK--PLTQSGGAPPPPGGKQQGRQCDETPPTSV 2150
PK ++ F+ E +E +E E +T+ K+ + +E P
Sbjct: 444 PKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEE 503
Query: 2151 SESAPSQTD-SDVPPET--EECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQD 2207
E A ++ PE EE + + E+E E +D+ + ++
Sbjct: 504 EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 563
Query: 2208 RSPSPRHPDVSMVDPEALAIEQNLGK------ALKKDLKEKTKTKKPGTKTKSSSPVKKS 2261
+ EA A E+ + A K++L K +KP K+ SPV KS
Sbjct: 564 GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP---EKAKSPVPKS 620
Query: 2262 ----DGKS-------KPLAASPKPAGLKESSDK--------VSRVASPKKKESVEKAAK- 2301
GKS + SP P E K + SP K VE+ AK
Sbjct: 621 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKS 680
Query: 2302 -----PTTTPEVKA--ARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVP 2351
P + KA +GE+K++E K A + + P K + P
Sbjct: 681 PVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESP 737
Score = 32.3 bits (72), Expect = 5.9
Identities = 63/311 (20%), Positives = 117/311 (37%), Gaps = 33/311 (10%)
Query: 1384 VPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVS 1443
V D +S +E+ L+ + + + E +A++K AE EE + K+ S
Sbjct: 462 VEDEKSEMEEALTAITEELAVSMKE--EKKEAAEEKEEEPEAEE--EEVAAKK------S 511
Query: 1444 PVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPT 1503
PV +T+ ++EG+ +E+ GQE++ ++ E S A K G
Sbjct: 512 PVK---ATAPEVKEEEGEK------EEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKE 562
Query: 1504 QIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFP 1563
+ G +E + +EG ++ E +E+ + E VA + P
Sbjct: 563 E------GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 616
Query: 1564 EPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPD 1623
P + SP + + S V+ SP +E+ P+S SP +
Sbjct: 617 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK-SPVPKSPVEEKGKSPVSKSPVE 675
Query: 1624 FSPKTAKSRTPVQDHRS-------EQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGV 1676
K+ ++PV++ +S EQ + +E+P++ + D P
Sbjct: 676 EKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAE 735
Query: 1677 LHITENGPTEV 1687
+ E EV
Sbjct: 736 SPVKEEAVAEV 746
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 [Homo
sapiens]
Length = 540
Score = 99.4 bits (246), Expect = 4e-20
Identities = 123/519 (23%), Positives = 222/519 (42%), Gaps = 86/519 (16%)
Query: 529 VVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMV 588
++++TK++ E A + S+++E KE EK + E++E+ +
Sbjct: 80 IIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAE--------EKEEEPEAEEEEVA 131
Query: 589 KKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPK---AAKEKTVKKETKVK 645
K P+K T P V E+E +EE + E ++ A + + + KE + +KE +
Sbjct: 132 AKKSPVKA-TAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQ 190
Query: 646 PEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKE--PKKEVKKE 703
E + E + + ++ AK+E K K EE KEE+ + K E K E+ K PK V+++
Sbjct: 191 EEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVE-KPEKAKSPVPKSPVEEK 249
Query: 704 TPPKEVKKEVKKEEKKEVKKE--EKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPK 761
K V+++ K V K E++ K + K P + +K +P+S++ K VPK
Sbjct: 250 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE-EKGKSPVSKSPVEEKAKSPVPK 308
Query: 762 K--EESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGP 819
EE+ K V G+ KE+ + +V KE E V
Sbjct: 309 SPVEEAKSKAEVGKGEQKEEEEKEV--KEAPKEEKV------------------------ 342
Query: 820 AKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQ 879
K+ E + + + + EE AE V +TK +K LE +E +E +P++ +
Sbjct: 343 EKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLE----KETKEEGKPLQQ---E 395
Query: 880 KEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSET 939
KE+E G S +EG + +G +G+ E+ +
Sbjct: 396 KEKEKAGGEGGSEEEG--SDKGA--------------------------KGSRKEDIAVN 427
Query: 940 GDYEEKAETEEAEEPEEDGEEH---VCVSASKHSPTEDEESA-KAEADAYIREKRESVAS 995
G+ E K E E+ + + G E V + SP ++++ K+E + + E + S
Sbjct: 428 GEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITS 487
Query: 996 -GDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEE 1033
G D A + + +++ + + EE EE + E+
Sbjct: 488 EGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEK 526
Score = 79.7 bits (195), Expect = 3e-14
Identities = 125/550 (22%), Positives = 215/550 (39%), Gaps = 83/550 (15%)
Query: 617 KAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPK 676
K + + +A +K + + + +ETKV ED+K E E+ + + E +K+E+K
Sbjct: 59 KIQKPKVEAPKLKVQHKFVEEIIEETKV--EDEKSEMEEALTAITE-ELAVSMKEEKKEA 115
Query: 677 KEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLP 736
EE KE + E ++EE K VK P EVK+E ++E++E ++EE+E
Sbjct: 116 AEE--KEEEPEAEEEEVAAKKSPVKATAP--EVKEEEGEKEEEEGQEEEEE--------- 162
Query: 737 KDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVA 796
++E K D G +++G + K+EG+ E
Sbjct: 163 -------------------------EDEGAKSDQAEEGGSEKEGSSE--KEEGEQEEGET 195
Query: 797 AAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKP 856
A G A K++E + +++ E+L D K E+ + K P
Sbjct: 196 EAEAEGEEAEA----------KEEKKVEEKSEEVATKEELVAD---AKVEKPEKAKSPVP 242
Query: 857 QLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVE 916
+ + EEK K P + + V K P E + E ++P PVE
Sbjct: 243 KSPV---EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE 299
Query: 917 KQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEE 976
++ + K E A + G+ +E+ E E E P+E+ V + P + E
Sbjct: 300 EKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEK-----VEKKEEKPKDVPE 354
Query: 977 SAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEP 1036
KAE+ E V E E+G+ Q E+E ++ + EE +
Sbjct: 355 KKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK 414
Query: 1037 EKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSES 1096
+ +AV E G EE + TK+ G+ GRE + L
Sbjct: 415 GAKGSRKEDIAV---NGEVEGKEE----VEQETKEKGS---GREEEKGVVTNGL------ 458
Query: 1097 EATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPS 1156
+ + +DE+ D+ EE T++ +I+SE + V + E E+
Sbjct: 459 DLSPADEKKGGDKSEEKVVV---TKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFE 515
Query: 1157 QEFVNITKYE 1166
++ V+ K E
Sbjct: 516 EKLVSTKKVE 525
Score = 57.4 bits (137), Expect = 2e-07
Identities = 60/242 (24%), Positives = 101/242 (41%), Gaps = 32/242 (13%)
Query: 2113 EEPTEESEKPLTQSGGAPPPPGG-KQQGRQCD-ETPPTSVSESAPSQTDSDVPPETEECP 2170
EE E ++ + GG+ K++G Q + ET + E A ++ + V ++EE
Sbjct: 161 EEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVA 220
Query: 2171 S---ITADANIDSEDESETIPTDKTVTYKHMDP-PPAPVQDR--SPSPRHPDVSMVDPEA 2224
+ + ADA ++ +++++ V K P P +PV+++ SP P+ P
Sbjct: 221 TKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSP--------- 271
Query: 2225 LAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKV 2284
+E+ K K+ K + K SPV KS + K A SP P E +
Sbjct: 272 --VEE----------KGKSPVPKSPVEEKGKSPVSKSPVEEK--AKSPVPKSPVEEAKSK 317
Query: 2285 SRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKT 2344
+ V ++KE EK K E K + EEK K+ A + + TK+
Sbjct: 318 AEVGKGEQKEEEEKEVKEAPKEE-KVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKS 376
Query: 2345 TK 2346
K
Sbjct: 377 VK 378
Score = 48.9 bits (115), Expect = 6e-05
Identities = 99/495 (20%), Positives = 169/495 (34%), Gaps = 86/495 (17%)
Query: 962 VCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEAD 1021
+ +S+ P + K + ++ E E D+++E M+EA+ E + +
Sbjct: 54 ITISSKIQKPKVEAPKLKVQ-HKFVEEIIEETKVEDEKSE--MEEALTAITEELAVSMKE 110
Query: 1022 EEDKAEDAREEEYEPEKMEA---EDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPG 1078
E+ +A + +EEE E E+ E + V A + E G +E+ + G +
Sbjct: 111 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEE---------EEGQEEEE 161
Query: 1079 REPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMST 1138
E + D+ GGSE E ++ EE +++ E G E +E++T
Sbjct: 162 EEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVAT 221
Query: 1139 PRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGK 1198
++++D + E P + + K S K P + E K+
Sbjct: 222 KEELVADA----KVEKPEKAKSPVPK------SPVEEKGKSPVPKSPVEEKGKSPV---- 267
Query: 1199 DYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPS 1258
P S E+K + S V + SP
Sbjct: 268 -----------PKSPVEEKGKSPVPK-------------------SPVEEKGKSPVSKSP 297
Query: 1259 LSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCAS-PEDKT 1317
+ SP+ K+P+ E + E K E EV E E EE PE K
Sbjct: 298 VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKK 357
Query: 1318 LEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASV 1377
E ++V + T KS + E K P+ E K++ +
Sbjct: 358 AESPVKEEAVA---------EVVTITKSVKVHLEKETKEEGKPLQQE----KEKEKAGGE 404
Query: 1378 SPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAE----------S 1427
+E D + + + + G E + +K SGR E S
Sbjct: 405 GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQ---ETKEKGSGREEEKGVVTNGLDLS 461
Query: 1428 PFEEKSGKQGSPDQV 1442
P +EK G S ++V
Sbjct: 462 PADEKKGGDKSEEKV 476
Score = 33.5 bits (75), Expect = 2.7
Identities = 40/209 (19%), Positives = 80/209 (38%), Gaps = 8/209 (3%)
Query: 2115 PTEESEKPLTQSGGAPPP----PGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECP 2170
P P+T S P P K Q + +E + E S+ + + TEE
Sbjct: 46 PLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELA 105
Query: 2171 SITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQN 2230
+ ++ +E E P + + + +PV+ +P + + + E E+
Sbjct: 106 VSMKEEKKEAAEEKEEEPEAEE---EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEE 162
Query: 2231 LGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASP 2290
+ K D E+ ++K G+ K ++ + +++ + K+ +K VA+
Sbjct: 163 EDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATK 222
Query: 2291 KKKESVEKAAKPTTTPE-VKAARGEEKDK 2318
++ + K KP V + EEK K
Sbjct: 223 EELVADAKVEKPEKAKSPVPKSPVEEKGK 251
Score = 33.1 bits (74), Expect = 3.5
Identities = 64/297 (21%), Positives = 102/297 (34%), Gaps = 41/297 (13%)
Query: 2093 PKTELSPSFINPNPLEWFASEEPTEESEK--PLTQSGGAPPPPGGKQQGRQCDETPPTSV 2150
PK ++ F+ E +E +E E +T+ K+ + +E P
Sbjct: 68 PKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEE 127
Query: 2151 SESAPSQTD-SDVPPET--EECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQD 2207
E A ++ PE EE + + E+E E +D+ + ++
Sbjct: 128 EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 187
Query: 2208 RSPSPRHPDVSMVDPEALAIEQNLGK------ALKKDLKEKTKTKKPGTKTKSSSPVKKS 2261
+ EA A E+ + A K++L K +KP K+ SPV KS
Sbjct: 188 GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP---EKAKSPVPKS 244
Query: 2262 ----DGKS-------KPLAASPKPAGLKESSDK--------VSRVASPKKKESVEKAAK- 2301
GKS + SP P E K + SP K VE+ AK
Sbjct: 245 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKS 304
Query: 2302 -----PTTTPEVKA--ARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVP 2351
P + KA +GE+K++E K A + + P K + P
Sbjct: 305 PVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESP 361
Score = 32.3 bits (72), Expect = 5.9
Identities = 63/311 (20%), Positives = 117/311 (37%), Gaps = 33/311 (10%)
Query: 1384 VPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVS 1443
V D +S +E+ L+ + + + E +A++K AE EE + K+ S
Sbjct: 86 VEDEKSEMEEALTAITEELAVSMKE--EKKEAAEEKEEEPEAEE--EEVAAKK------S 135
Query: 1444 PVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPT 1503
PV +T+ ++EG+ +E+ GQE++ ++ E S A K G
Sbjct: 136 PVK---ATAPEVKEEEGEK------EEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKE 186
Query: 1504 QIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFP 1563
+ G +E + +EG ++ E +E+ + E VA + P
Sbjct: 187 E------GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 240
Query: 1564 EPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPD 1623
P + SP + + S V+ SP +E+ P+S SP +
Sbjct: 241 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK-SPVPKSPVEEKGKSPVSKSPVE 299
Query: 1624 FSPKTAKSRTPVQDHRS-------EQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGV 1676
K+ ++PV++ +S EQ + +E+P++ + D P
Sbjct: 300 EKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAE 359
Query: 1677 LHITENGPTEV 1687
+ E EV
Sbjct: 360 SPVKEEAVAEV 370
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 98.6 bits (244), Expect = 7e-20
Identities = 127/575 (22%), Positives = 251/575 (43%), Gaps = 86/575 (14%)
Query: 482 EKIIRVLFPGNSTQYNILEGLEKLKHLDFL--KQPLATQKDLTGQVPTPVVKQTKLKQRA 539
EK+ V + Q N+ E KL+ L +Q L + D G+ V KL+ +
Sbjct: 228 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV--SAKLQAQV 285
Query: 540 DSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETK 599
+ E + K R+E K + E K+ E+ + E +EK+ +++K + E
Sbjct: 286 EENELWNRLNQQQEEKMWRQEEKIQEWE-EKIQEQEEKIR-EQEEKIREQEEKMRRQEEM 343
Query: 600 PSVTEKEVPSKEEPSPVKAEVAEKQAT-----DVKPKAAKEKTVKKETKVKP-EDKKEEK 653
E+++ +EE K E +Q + K + +E +KE K++ E+K E+
Sbjct: 344 MWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ 403
Query: 654 EKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEV 713
EK +++ K++++ I+++EK +++E K ++EEK ++E +E K ++E
Sbjct: 404 EKIREQEEKRQEEEKIREQEKRQEQEAKMW-----RQEEKIREQEEKIREQEKKMWRQEE 458
Query: 714 KKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAA 773
K E++++++EEK ++E + + + E ++ K K+ ++EE ++K
Sbjct: 459 KIHEQEKIREEEKRQEQE------EMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKV 512
Query: 774 GKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSP 833
+ +EK + ++E K E + M
Sbjct: 513 WRQEEK----IREQEEKIRE--------------------------------QEEKMWRQ 536
Query: 834 EDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPV----EAYVIQKEREVTKGPA 889
E+ ++ EE+ EE + + E I +EEK +E E E + ++E +V +
Sbjct: 537 EEKIREQEEMWREEEKMHEQ-----EKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEE 591
Query: 890 ESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETE 949
+ ++ E E + + E++ E++ + EK ++ E E T+
Sbjct: 592 KIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEM--------TQ 643
Query: 950 EAEEPEEDGEEHVCVSASKHSPTED----EESAKAEADAYIREKRESVASGDDRAEEDMD 1005
E EE + EE +C K E+ +E E + IRE+ E + R +E+M
Sbjct: 644 EQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKI-----REQEEMM 698
Query: 1006 EAIEKGEAEQSEEEADEEDKAEDAREE-EYEPEKM 1039
+ E+ EQ E+ ++E+K ++ E+ + EKM
Sbjct: 699 QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM 733
Score = 65.5 bits (158), Expect = 6e-10
Identities = 93/527 (17%), Positives = 221/527 (41%), Gaps = 29/527 (5%)
Query: 601 SVTEKEVPSKEEPSPVKAEVAEKQATDVK--PKAAKEKTVKKETKVKPEDKKEEKEKPKK 658
++T++E+ K K ++ E + ++++ K K K + + + + + E + K
Sbjct: 213 TITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGK 272
Query: 659 EVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEK 718
E+ K + EE + ++ ++++ ++E+K + E K + E +++++++E+
Sbjct: 273 ELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQ----EQEEKIREQEE 328
Query: 719 KEVKKEEKEPKKEIKKLPKDAK---KSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGK 775
K ++EEK ++E K+ K + + +K + + +KEE +++ +
Sbjct: 329 KIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 388
Query: 776 PKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPED 835
+EK I+ ++++ E + + K E E + E
Sbjct: 389 KEEK--IRELEEKMHEQEKIREQEEKRQEEEKIREQE--------KRQEQEAKMWRQEEK 438
Query: 836 LTKDFEELKAEEVDVTKDIKP--QLELIEDEEKLKETEPV--EAYVIQKEREVTKGPAES 891
+ + E+++ +E + + + + E I +EEK +E E + + I ++ E+ + +
Sbjct: 439 IREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKM 498
Query: 892 PDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEA 951
++ + E + + E++ E++ + EK + E E EEK +E
Sbjct: 499 HEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEK 558
Query: 952 EEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKG 1011
EE +E + ++E + IRE+ E +++ + ++ E+
Sbjct: 559 IWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQE 618
Query: 1012 EAEQSEEE--ADEEDKAEDARE--EEYEPEKMEAEDYVMAVVDKAAEAGGAE-EQYGFLT 1066
E Q +EE ++E+K + E +E E + E E+ + +K E Q +
Sbjct: 619 EKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIR 678
Query: 1067 TPTKQLGAQSPG-REPASSIHDETLPGGSESEATASDEENREDQPEE 1112
K++ Q RE + ++ + E EE ++Q E+
Sbjct: 679 EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 725
Score = 59.7 bits (143), Expect = 3e-08
Identities = 51/214 (23%), Positives = 118/214 (55%), Gaps = 13/214 (6%)
Query: 559 KESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKA 618
+E +E E K++ EK + +EK ++DK + E K E++V +EE ++
Sbjct: 541 REQEEMWREEEKMHEQEK---IWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEK--IRE 595
Query: 619 EVAEKQATDVKPKAAKEKTVKKETKVKPEDKK----EEKEKPKKEVAKKEDKTPIKKEEK 674
+ ++Q + K +EK ++E K++ +++K EEK + ++E+ +++++ ++EEK
Sbjct: 596 QEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEK 655
Query: 675 PKKEEVKKEVKKEI--KKEEK--KEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKK 730
++E K + ++E ++EEK ++ KK ++E +E ++ ++++E+K ++EEK ++
Sbjct: 656 MCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 715
Query: 731 EIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEE 764
E K ++ K ++ L+ + K +E
Sbjct: 716 EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 56.2 bits (134), Expect = 4e-07
Identities = 34/177 (19%), Positives = 104/177 (58%), Gaps = 5/177 (2%)
Query: 555 KSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPS 614
+ +R++ ++ + K+ E+ K + +E+ M K+++ I+ E + + E+E +E+
Sbjct: 577 EKIREQEEKVWRQEEKIREQEE--KRQEQEEKMWKQEEKIR-EQEEKIQEQEEKIREQEE 633
Query: 615 PVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEK 674
++ + Q + K +EK ++E K+ ++++E + ++++ ++E K ++E+
Sbjct: 634 KIREQEEMTQEQEEKMGEQEEKMCEQEEKM--QEQEETMWRQEEKIREQEKKIREQEEKI 691
Query: 675 PKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKE 731
++EE+ +E ++++ ++E+K ++E K + ++++++ +K ++EV+ ++E K +
Sbjct: 692 REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Score = 33.1 bits (74), Expect = 3.5
Identities = 31/164 (18%), Positives = 81/164 (49%), Gaps = 9/164 (5%)
Query: 530 VKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVK 589
+++ + K++ + K K + +E +E+ E + ++ E +EK+ +
Sbjct: 593 IREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQ 652
Query: 590 KDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDK 649
++K + E K E+ + +EE ++ + + + + K + +E ++E K+ +++
Sbjct: 653 EEKMCEQEEKMQEQEETMWRQEEK--IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 710
Query: 650 K--EEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKE 691
K E++EK +++ K ++EEK ++EV+ ++E +E
Sbjct: 711 KMCEQEEKMQEQEEKMR-----RQEEKMWEQEVRLRQQEEKMQE 749
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 97.8 bits (242), Expect = 1e-19
Identities = 150/629 (23%), Positives = 244/629 (38%), Gaps = 100/629 (15%)
Query: 725 EKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKV 784
E +P+ E + P+ + EA+ P + + P+ E + +S P+ + +++
Sbjct: 1843 EAQPESEGVEAPEAEGDAQEAEGEAQ-PESEDVEAPEAEGEAQPESEDVETPEAEWEVQ- 1900
Query: 785 IKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELK 844
E + AEA A T +V A E E E PE + +E +
Sbjct: 1901 --PESEGAEAPEAEKEAQPETESVEAL----------ETEGE----DEPESEGAEAQEAE 1944
Query: 845 AEEVDVTKDIKPQLELIEDEEKLKETEP----VEAYVIQKEREVTKGPAESPDEGITTTE 900
+ +P+ E+IE +E +E +P VEA ++ E + +G A+ E + E
Sbjct: 1945 EAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPE 2004
Query: 901 GEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSET----GDYEEKAETEEAEEPEE 956
EGE ++ EE +P E GV+ K E E A E ET GD + +++ EA E EE
Sbjct: 2005 AEGEMQEAEEEAQP-ESDGVEAQPKSEGEEAQ-EVEGETQKTEGDAQPESDGVEAPEAEE 2062
Query: 957 DGEEHVC----VSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGE 1012
+ +E H +ED ++ +AE +A + + E V + + E E IE E
Sbjct: 2063 EAQEAEGEVQEAEGEAHPESEDVDAQEAEGEA--QPESEGVEAPEAEGEAQKAEGIEAPE 2120
Query: 1013 AE---QSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPT 1069
E Q E E E +AE E + E E +EA+D A + E+ G E Q
Sbjct: 2121 TEGEAQPESEGIEAPEAEG--EAQPESEGVEAQD---AEGEAQPESEGIEAQEAEEEAQP 2175
Query: 1070 KQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSE 1129
+ G ++P E E P ESE + E E QPE G E ++
Sbjct: 2176 ELEGVEAPEAE------GEAQP---ESEGIEAPEAEGEAQPE----LEGVEAPEAEEEAQ 2222
Query: 1130 PTPMDEMSTP------RDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPL 1183
P P + + TP + ET E+ SP V++ +S S+ S + P
Sbjct: 2223 PEP-EGVETPEAEGEAQPESEGETQGEKKGSPQ---VSLGDGQSEEASESSSPVPEDRPT 2278
Query: 1184 NGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSI 1243
S G T + + + PSS + +D+ V T
Sbjct: 2279 PPPSPGGDTP-------HQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTR------- 2324
Query: 1244 SAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQ 1303
SP + TP ER + ++E E AP+ +
Sbjct: 2325 ------------------SPDAKSTGTPHAERKATRMYPESS---TSEQEEAPLGSRTPE 2363
Query: 1304 EVVEEHCASPEDKTLEVVSPSQSVTGSAG 1332
+ E ED+ L ++P+++V + G
Sbjct: 2364 QGASEGYDLQEDQALGSLAPTEAVGRADG 2392
Score = 93.2 bits (230), Expect = 3e-18
Identities = 128/568 (22%), Positives = 234/568 (41%), Gaps = 66/568 (11%)
Query: 604 EKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKK 663
E E ++ E V+A AE A + + +A E V+ + + E + ++V
Sbjct: 1839 EAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESE-----DVEAPEAEGEAQPESEDVETP 1893
Query: 664 EDKTPIKKE-EKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVK 722
E + ++ E E + E +KE + E + E E + E + P E + + EE +
Sbjct: 1894 EAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGE---DEPESEGAEAQEAEEAAQEA 1950
Query: 723 KEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKI 782
+ + +P+ E+ + ++A++ + P SE + ++ + + E + +S P+ +G++
Sbjct: 1951 EGQTQPESEVIE-SQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEM 2009
Query: 783 KVIKKEGK----AAEAVAAAVGTGATTA----------AVMAAAGIAAIGPAKEL-EAER 827
+ ++E + EA + G A A + G+ A +E EAE
Sbjct: 2010 QEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEG 2069
Query: 828 SLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKG 887
+ + + + E++ A+E + + +P+ E +E E E + E E T+G
Sbjct: 2070 EVQEAEGEAHPESEDVDAQEAE--GEAQPESEGVEAPEAEGEAQKAEGI----EAPETEG 2123
Query: 888 PAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAE 947
A+ EGI E EGE + E E VE Q + + E EG +E+ E E + E
Sbjct: 2124 EAQPESEGIEAPEAEGEAQ---PESEGVEAQDAEGEAQPESEGIEAQEAEE----EAQPE 2176
Query: 948 TEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEA 1007
E E PE +GE + E E EA+ + + E V + + AEE+
Sbjct: 2177 LEGVEAPEAEGE----------AQPESEGIEAPEAEGEAQPELEGVEAPE--AEEEAQPE 2224
Query: 1008 IEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTT 1067
E E ++E EA E + E E++ P+ + ++A+E+ + T
Sbjct: 2225 PEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGD----GQSEEASESSSPVPE--DRPT 2278
Query: 1068 PTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEIS 1127
P G +P + P S + S D EN G T+S +
Sbjct: 2279 PPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDH--------VLGDTRSP-DAK 2329
Query: 1128 SEPTPMDEMSTPRDVMSDETNNEETESP 1155
S TP E R + + + +E+ E+P
Sbjct: 2330 STGTPHAERKATR-MYPESSTSEQEEAP 2356
Score = 88.6 bits (218), Expect = 7e-17
Identities = 125/513 (24%), Positives = 198/513 (38%), Gaps = 56/513 (10%)
Query: 772 AAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMS 831
AAG ++ G + AE + A G A G A+E E E S
Sbjct: 1819 AAGGDQDPG-------QSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPES 1871
Query: 832 SPEDLTKDFEELKAEEVDVTK-----DIKPQLELIE----DEEKLKETEPVEAYVIQKER 882
+ + E + E DV +++P+ E E ++E ETE VEA + E
Sbjct: 1872 EDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGED 1931
Query: 883 EVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDY 942
E AE+ + E EG+ + E +E E + E + E E ++ +
Sbjct: 1932 EPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEG 1991
Query: 943 EEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEA-DAYIREKRESVASGDDRAE 1001
E + E+E+ E PE +GE ++ E K+E +A E GD + E
Sbjct: 1992 EAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPE 2051
Query: 1002 EDMDEAIE-KGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEE 1060
D EA E + EA+++E E E + E+ + ++ E E + +A EA G +
Sbjct: 2052 SDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQ 2111
Query: 1061 QYGFLTTPTKQLGAQ--SPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSG 1118
+ + P + AQ S G E A E P ESE + + E QPE + G
Sbjct: 2112 KAEGIEAPETEGEAQPESEGIE-APEAEGEAQP---ESEGVEAQDAEGEAQPE----SEG 2163
Query: 1119 YTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPA 1178
E ++P ++ + P + +E E+P E + E + + E + A
Sbjct: 2164 IEAQEAEEEAQP-ELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELE-GVEAPEAEEEA 2221
Query: 1179 DVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLD 1238
P EG +T +G+ + P S E + E K S +
Sbjct: 2222 QPEP-----EGVETPEAEGE---------AQPESEGETQ-----------GEKKGSPQVS 2256
Query: 1239 IKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTP 1271
+ D S +SE SP +P PPSP TP
Sbjct: 2257 LGDGQSEEASESSSPVPEDRPTP-PPSPGGDTP 2288
Score = 78.6 bits (192), Expect = 7e-14
Identities = 111/508 (21%), Positives = 205/508 (40%), Gaps = 52/508 (10%)
Query: 557 VRKESK-EETPEVTKVNHVEKPPKVESKEKVMVK-KDKPIKTETKPSVTEKEVPSKEEPS 614
V+ ES+ E PE K E P+ ES E + + +D+P + E+ E +
Sbjct: 1899 VQPESEGAEAPEAEK----EAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQT 1954
Query: 615 PVKAEVAEKQ---------ATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKED 665
++EV E Q + DV+ + +T + E + +PE + E + + E+ + E+
Sbjct: 1955 QPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEE 2014
Query: 666 KTPIKK---EEKPKKE-EVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEV 721
+ + E +PK E E +EV+ E +K E + E P E E +E + EV
Sbjct: 2015 EAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAE---EEAQEAEGEV 2071
Query: 722 KKEEKEPKKEIKKL-PKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKG 780
++ E E E + + ++A+ + P SE + + + K E ++ +P+ +G
Sbjct: 2072 QEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEG 2131
Query: 781 KIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPE---DLT 837
I+ + EG+A A A + GI A +E + E + +PE +
Sbjct: 2132 -IEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQ 2190
Query: 838 KDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGIT 897
+ E ++A E + + +P+LE +E E +E +P EG+
Sbjct: 2191 PESEGIEAPEAE--GEAQPELEGVEAPEAEEEAQP-------------------EPEGVE 2229
Query: 898 TTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSE--TGDYEEKAETEEAEEPE 955
T E EGE + E EK+G + + + ESS D + + P
Sbjct: 2230 TPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPH 2289
Query: 956 EDGEEHVCVSASKHSPTEDEESAKAEADAYIREKR--ESVASGDDRAEEDMDEAIEKGEA 1013
+ S+S+ S + +E D + + R ++ ++G AE +
Sbjct: 2290 QRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESST 2349
Query: 1014 EQSEEEADEEDKAEDAREEEYEPEKMEA 1041
+ EE E E Y+ ++ +A
Sbjct: 2350 SEQEEAPLGSRTPEQGASEGYDLQEDQA 2377
Score = 66.6 bits (161), Expect = 3e-10
Identities = 148/687 (21%), Positives = 250/687 (36%), Gaps = 110/687 (16%)
Query: 893 DEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETG----DYEEKAET 948
D + EG+ ++ + E ++ + E EG G E ETG +E+ +
Sbjct: 1757 DPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQG 1816
Query: 949 EEA----EEP-EEDGEEHV-CVSASKHSPTEDE--ESAKAEADAYIREKRESVASGDDRA 1000
E A ++P + DG E + A + E E E+ +AE DA E S D A
Sbjct: 1817 EAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEA 1876
Query: 1001 EEDMDEA-IEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAE 1059
E EA E + E E E + + ++E A E E E + V +A E G +
Sbjct: 1877 PEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESV-----EALETEGED 1931
Query: 1060 EQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGY 1119
E P + E A +T P ESE S E E QPE
Sbjct: 1932 E-------PESEGAEAQEAEEAAQEAEGQTQP---ESEVIESQEAEEEAQPESEDV---- 1977
Query: 1120 TQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYES-SLYSQEYSKPA 1178
+E+ E + + P S++ E E QE + ES + +Q S+
Sbjct: 1978 --EALEVEVETQEAEGEAQPE---SEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGE 2032
Query: 1179 DVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLD 1238
+ + G +T T+G D + + P + EE + + +++A S +D
Sbjct: 2033 EAQEVEG-----ETQKTEG-DAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVD 2086
Query: 1239 IKDSISAVSSE--------------KVSPSKSPSL--SPSPPSPLEKTPLGERSVNFSLT 1282
+++ E K ++P P S + P E
Sbjct: 2087 AQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESE 2146
Query: 1283 PNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTD 1342
E + AE E P S + + EE A PE LE V ++ + + ++P
Sbjct: 2147 GVEAQ-DAEGEAQPESEGIEAQEAEEE-AQPE---LEGVEAPEAEGEAQPESEGIEAPEA 2201
Query: 1343 EKSSHLPTEVIEKPPA------VPVSFEFSDAKDENERASV---------SP-------M 1380
E + E +E P A P E +A+ E + S SP
Sbjct: 2202 EGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQ 2261
Query: 1381 DEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGA--------ESPFEEK 1432
E +S SP+ + PP G ++ ++ S +S R + +S +
Sbjct: 2262 SEEASESSSPVPE--DRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHV 2319
Query: 1433 SGKQGSPDQVS---PVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPA 1489
G SPD S P +E +T +Y + + + AP+ ++ ++ +
Sbjct: 2320 LGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEE-APLGSRTPEQGASEGYDLQ----- 2373
Query: 1490 LALDERKLGDVSPTQIDVSQFGSFKED 1516
+++ LG ++PT+ V + F +D
Sbjct: 2374 ---EDQALGSLAPTEA-VGRADGFGQD 2396
Score = 56.2 bits (134), Expect = 4e-07
Identities = 114/552 (20%), Positives = 201/552 (36%), Gaps = 55/552 (9%)
Query: 956 EDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGE--- 1012
EDGE + + + +D + +AE DA +E+ + + A ++ EA ++GE
Sbjct: 1744 EDGE-----GSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGIS 1798
Query: 1013 --AEQSEEEADEED--KAEDAREEEYEPEKMEAEDYVMAVVDKAAEA-GGAEEQYGFLTT 1067
E + + ED + E A + +P + + + + +A EA G A+ + +
Sbjct: 1799 ERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGI-----EAPEAEGEAQPESEGVEA 1853
Query: 1068 PTKQLGAQSPGREPASSIHDETLPGGS-----ESEATASDEENREDQPEEFTATSGYTQS 1122
P + AQ E D P ESE + E E QPE A + +
Sbjct: 1854 PEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEK 1913
Query: 1123 TIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESS-LYSQEYSKPA--D 1179
+ +E E + S+ +E E +QE T+ ES + SQE + A +
Sbjct: 1914 EAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPE 1973
Query: 1180 VTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDI 1239
+ +T +G+ S +P + E + A ++ E + + +
Sbjct: 1974 SEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEE 2033
Query: 1240 KDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSP 1299
+ + + ++ S P E+ E V AE E P S
Sbjct: 2034 AQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQ----------EAEGEAHPESE 2083
Query: 1300 EVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAV 1359
+V + E A PE + +E + G A ++P E + +E IE P A
Sbjct: 2084 DVDAQEAEGE-AQPESEGVE----APEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAE 2138
Query: 1360 PVSFEFSDAKDENERASVSPMD-EPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADD 1418
+A+ E+E + E P+SE + P L G E+ +
Sbjct: 2139 ------GEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPE---AEGEA 2189
Query: 1419 KASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKT 1478
+ G E+P E + +P +E + Q + EG T A + E +T
Sbjct: 2190 QPESEGIEAPEAEGEAQPELEGVEAPEAEEEA----QPEPEGVETPEAEGEAQPESEGET 2245
Query: 1479 DDVEAMSSQPAL 1490
+ S Q +L
Sbjct: 2246 QGEKKGSPQVSL 2257
Score = 40.8 bits (94), Expect = 0.017
Identities = 63/256 (24%), Positives = 98/256 (38%), Gaps = 47/256 (18%)
Query: 862 EDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEG------ECEQTPEELEPV 915
E++ E + +Q+E ++ E EG TEGEG + E+T E E +
Sbjct: 1281 EEQRASSNLEQLAENTVQEEVQL-----EETKEG---TEGEGLQEEAVQLEETKTE-EGL 1331
Query: 916 EKQGVDDIEKFEDEGAG-------FEESSETGD---YEEKAETEEAEEPEEDGEEHVCVS 965
+++GV E E EG G EE ETG EE + EE +E E G + +
Sbjct: 1332 QEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALE 1391
Query: 966 ASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDK 1025
EE E + +E E AS D D+ +++ EA ++ A E
Sbjct: 1392 EGL-----KEEGLPEEGSVHGQELSE--ASSPDGKGSQEDDPVQEEEAGRA--SASAEPC 1442
Query: 1026 AEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSI 1085
+ EE EP +E + +E Q G P + + PG
Sbjct: 1443 PAEGTEEPTEPPSHLSE----------TDPSASERQSGSQLEPGLE---KPPGATMMGQE 1489
Query: 1086 HDETLPGGSESEATAS 1101
H + P +E ++S
Sbjct: 1490 HTQAQPTQGAAERSSS 1505
Score = 40.0 bits (92), Expect = 0.028
Identities = 69/330 (20%), Positives = 117/330 (35%), Gaps = 58/330 (17%)
Query: 910 EELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKH 969
E P GVD G ESS + T+ E P + + S +
Sbjct: 1191 ENFTPTSSSGVD----ISSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQRPD-SRTYE 1245
Query: 970 SPTEDEESAKAEADAYIREKRESVASGDDRAEED-----------------------MDE 1006
SP + E + ++ + + A+ +D AE D ++E
Sbjct: 1246 SPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEE 1305
Query: 1007 AIEKGEAEQSEEEAD--EEDKAEDAREE---------EYEPEKMEAEDYVMAVVDKAAEA 1055
E E E +EEA EE K E+ +E E E E + E+ + +++
Sbjct: 1306 TKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGE 1365
Query: 1056 GGAEE----------QYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEEN 1105
G EE G L + G + G S+H + L S + S E++
Sbjct: 1366 GLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDD 1425
Query: 1106 REDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKY 1165
+ E A++ E + EPT P + + + E +S SQ + K
Sbjct: 1426 PVQEEEAGRASASAEPCPAEGTEEPT-----EPPSHLSETDPSASERQSGSQLEPGLEKP 1480
Query: 1166 E-SSLYSQEYSKPADVTPLNGFSEGSKTDA 1194
+++ QE+++ P G +E S + A
Sbjct: 1481 PGATMMGQEHTQ---AQPTQGAAERSSSVA 1507
Score = 39.3 bits (90), Expect = 0.048
Identities = 46/226 (20%), Positives = 95/226 (42%), Gaps = 8/226 (3%)
Query: 525 VPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKE 584
V P ++ + + +E+ A ++ E PE V E + + E
Sbjct: 2055 VEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAE 2114
Query: 585 KVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKV 644
+ + + E +P E P E + ++E E Q + + + E +E +
Sbjct: 2115 GIEAPETEG---EAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEE 2171
Query: 645 KPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKET 704
+ + + E E P+ E + + I+ E + + + E + + EE+ +P+ E ET
Sbjct: 2172 EAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPE-GVET 2230
Query: 705 PPKEVKKEVKKEEKKEVKKEEK-EPKKEI-KKLPKDAKKSSTPLSE 748
P E + E + E + E + E+K P+ + ++A +SS+P+ E
Sbjct: 2231 P--EAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPE 2274
Score = 38.9 bits (89), Expect = 0.063
Identities = 63/351 (17%), Positives = 127/351 (36%), Gaps = 29/351 (8%)
Query: 2018 PESEGYSYETSTKTTRT------PDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKK 2071
PESEG + + + + P++ + AE+ + + E AE +
Sbjct: 1933 PESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGE 1992
Query: 2072 SPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPP 2131
+ E+ +DV+ E + + E P EE E + G A P
Sbjct: 1993 AQPES-EDVEAPEAEG-EMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQP 2050
Query: 2132 PPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDK 2191
G + +E +E + + + PE+E+ + A+ E E P +
Sbjct: 2051 ESDGVEAPEAEEEAQE---AEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAE 2107
Query: 2192 TVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTK 2251
K + AP + P + + E A ++ G + D + + + + G +
Sbjct: 2108 GEAQK-AEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQ-DAEGEAQPESEGIE 2165
Query: 2252 TKSSSPVKKSD--GKSKPLA---ASPKPAGLK------ESSDKVSRVASPKKKESVEKAA 2300
+ + + + G P A A P+ G++ E+ ++ V +P+ +E +
Sbjct: 2166 AQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEP 2225
Query: 2301 KPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVP 2351
+ TPE + E + ET+ K + + G G ++ S+ P
Sbjct: 2226 EGVETPEAEGEAQPESEGETQ-----GEKKGSPQVSLGDGQSEEASESSSP 2271
Score = 35.8 bits (81), Expect = 0.54
Identities = 55/230 (23%), Positives = 89/230 (38%), Gaps = 20/230 (8%)
Query: 900 EGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGE 959
E + E ++ LE + + V + + E+ G E + + ET+ E +E+G
Sbjct: 1277 ERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEG- 1335
Query: 960 EHVCVSASKHSPTEDEESAKAEADAYIREKRESVASG---DDRAEEDMDEAIEKG-EAEQ 1015
V + TE E + E +A + E E+ G + E++ E E G + E
Sbjct: 1336 ----VQLEETKETEGE--GQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEA 1389
Query: 1016 SEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVD---KAAEAGGAEEQYGFLTTPTKQL 1072
EE EE E+ E + + D + D + EAG A P
Sbjct: 1390 LEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASAS----AEPCPAE 1445
Query: 1073 GAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQS 1122
G + P EP S + ET P SE ++ + E E P +TQ+
Sbjct: 1446 GTEEP-TEPPSHL-SETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQA 1493
Score = 34.3 bits (77), Expect = 1.6
Identities = 50/241 (20%), Positives = 86/241 (35%), Gaps = 35/241 (14%)
Query: 2113 EEPTEESE-KPLTQSGGAPPPPG------GKQQGRQCDETPPTSVSESAPSQTDSDVP-- 2163
E P E E +P ++ AP G G+ Q D P + E+ P D + P
Sbjct: 1836 EAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEA 1895
Query: 2164 -----PETE--ECPSITADANIDSED------ESETIPTDKTVTYKHMD----------P 2200
PE+E E P +A ++E E E P + + +
Sbjct: 1896 EWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQ 1955
Query: 2201 PPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKK 2260
P + V + + D EAL +E +A + E + P + + ++
Sbjct: 1956 PESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEE 2015
Query: 2261 SDGKSKPLAASPKPAG--LKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDK 2318
+ +S + A PK G +E + + + ES + P E + A GE ++
Sbjct: 2016 AQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES-DGVEAPEAEEEAQEAEGEVQEA 2074
Query: 2319 E 2319
E
Sbjct: 2075 E 2075
Score = 33.5 bits (75), Expect = 2.7
Identities = 46/221 (20%), Positives = 80/221 (36%), Gaps = 26/221 (11%)
Query: 2134 GGKQQGRQCDETPPTSVSESAPSQTDSDVPPETE--ECPSITADANIDSEDESETIPTDK 2191
GG Q Q D E+ + + PE+E E P DA E E E P +
Sbjct: 1821 GGDQDPGQSDGAEGIEAPEA-----EGEAQPESEGVEAPEAEGDAQ---EAEGEAQPESE 1872
Query: 2192 TVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTK 2251
V AP + P DV + E ++ G + E K +P T+
Sbjct: 1873 DVE--------APEAEGEAQPESEDVETPEAEWEVQPESEGA----EAPEAEKEAQPETE 1920
Query: 2252 TKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAA 2311
S +++G+ +P + + +E++ + P+ + + A+ PE +
Sbjct: 1921 ---SVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDV 1977
Query: 2312 RGEEKDKETKNAANASASKSAKT-ATAGPGTTKTTKSSAVP 2351
E + ET+ A + +S A G + + A P
Sbjct: 1978 EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQP 2018
>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
Length = 825
Score = 94.4 bits (233), Expect = 1e-18
Identities = 202/905 (22%), Positives = 351/905 (38%), Gaps = 122/905 (13%)
Query: 491 GNSTQYNILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAK 550
G S Q +++E K KH+ P ++ T ++ +K A + ES++ +++
Sbjct: 3 GKSQQTDVIE---KKKHMAI---PKSSSPKATHRIGN--TSGSKGSYSAKAYESIRVSSE 54
Query: 551 PLPSKSVRKESKEETPEVTKVNH-VEKPPKVESKEKVMVKKDKPIKT-----ETKPSVTE 604
+ + RK +E T + + + VE+ +V+ E+ +V ++K E SV +
Sbjct: 55 LQQTWTKRKHGQEMTSKSLQTDTIVEEKKEVKLVEETVVPEEKSADVREAAIELPESVQD 114
Query: 605 KEVPSKEEPSPVKAEVAEKQATD----------VKPKAAKEKTVKKETKVKPEDKKEEKE 654
E+P +K + +++ + V+ +++T E+++ + +
Sbjct: 115 VEIPPNIPSVQLKMDRSQQTSRTGYWTMMNIPPVEKVDKEQQTYFSESEIVVISRPDSSS 174
Query: 655 -KPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEV 713
K K++ K + I E P+ + ++ +K + + K+ PP ++ E+
Sbjct: 175 TKSKEDALKHKSSGKIFASEHPEFQPATNSNEEIGQKNISRTSFTQETKKGPPVLLEDEL 234
Query: 714 KKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAA 773
++E V +E KK A P S K PA ++P P EE+ K A
Sbjct: 235 REEVTVPVVQEGSAVKKV-------ASAEIEPPSTEKFPAKIQP--PLVEEATAK---AE 282
Query: 774 GKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSP 833
+P E+ ++V + +A AA T +V A P E AE S+
Sbjct: 283 PRPAEETHVQVQPSTEETPDAEAA---TAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAE 339
Query: 834 EDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAY---VIQKEREVTKGPAE 890
E + EL AE + P E EE E P A ++ E+ A+
Sbjct: 340 ESPS---VELLAE------ILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQ 390
Query: 891 SPDEGITTTEGEGECEQTPEELE-PVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETE 949
+ EG E+ P ++E P ++ + D++ E A EE+ E ET
Sbjct: 391 KAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEAREL-QLSTAMETP 449
Query: 950 EAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIE 1009
E P E SP E +A+ EA A I + +A+ + A+E EA
Sbjct: 450 AEEAPTE-----------FQSPLPKETTAE-EASAEI----QLLAATEPPADETPAEARS 493
Query: 1010 KGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPT 1069
E S EEA E + EE E+ AE ++A ++ A+ AE Q
Sbjct: 494 PLSEETSAEEAHAE--VQSPLAEETTAEEASAEIQLLAAIEAPADETPAEAQ-------- 543
Query: 1070 KQLGAQSPGREPASSIHDETLPGGSESEA--TASDEENREDQPEEFTATSGYTQSTIEIS 1127
L ++ E + + + G S EA E EE +A +T E S
Sbjct: 544 SPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAEEASAAIQLLAAT-EAS 602
Query: 1128 SEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFS 1187
+E P + P ++E E P++E PA+V P
Sbjct: 603 AEEAPAEVQPPP----AEEAPAEVQPPPAEE-----------------APAEVQPPPAEE 641
Query: 1188 EGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKA--STTLDIKDSISA 1245
++ ++ + + + PP + E + + +EV++ + I+++++A
Sbjct: 642 APAEVQPPPAEE---APAEVQPPPAEEAPAEVQPPPAEEAPAEVQSLPAEETPIEETLAA 698
Query: 1246 VSSEKVS--PSKSPSLSP-SPPSPL---EKTPLGERSVNFSLTPNEIKVSAEAEVAPVSP 1299
V S P++ S+ SPP+ L E+ P+GE S S P+E EA V VS
Sbjct: 699 VHSPPADDVPAEEASVDKHSPPADLLLTEEFPIGEASAEVSPPPSEQTPEDEALVENVST 758
Query: 1300 EVTQEVVE-------EHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEV 1352
E V + E VS SV +T Q+PT E S E+
Sbjct: 759 EFQSPQVAGIPAVKLGSVVLEGEAKFEEVSKINSVLKDLSNTNDGQAPTLEIESVFHIEL 818
Query: 1353 IEKPP 1357
++PP
Sbjct: 819 KQRPP 823
Score = 76.3 bits (186), Expect = 4e-13
Identities = 161/805 (20%), Positives = 293/805 (36%), Gaps = 76/805 (9%)
Query: 638 VKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPK 697
V K + +KK+ PK K + K E + + ++ K
Sbjct: 2 VGKSQQTDVIEKKKHMAIPKSSSPKATHRIGNTSGSKGSYSAKAYESIRVSSELQQTWTK 61
Query: 698 KEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKP 757
++ +E K ++ + EEKKEVK E+ E K D ++++ L E+ + + P
Sbjct: 62 RKHGQEMTSKSLQTDTIVEEKKEVKLVEETVVPEEKSA--DVREAAIELPESVQDVEIPP 119
Query: 758 KVP----KKEESVKKDSVAAGKPKEKGKIKVIKKEGKA--AEAVAAAVGTGATTAAVMAA 811
+P K + S + ++ + KE + +E+ + +++
Sbjct: 120 NIPSVQLKMDRSQQTSRTGYWTMMNIPPVEKVDKEQQTYFSESEIVVISRPDSSSTKSKE 179
Query: 812 AGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIK--PQLELIEDEEKLKE 869
+ K +E + ++ + T++ K P + L+EDE + +
Sbjct: 180 DALKHKSSGKIFASEHPEFQPATNSNEEIGQKNISRTSFTQETKKGPPV-LLEDELREEV 238
Query: 870 TEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDE 929
T PV +E K A + E +T E+ P +++P +E
Sbjct: 239 TVPVV-----QEGSAVKKVASAEIEPPST-------EKFPAKIQP----------PLVEE 276
Query: 930 GAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREK 989
E + + + E P+ + V ++ K P EE+ E A I+
Sbjct: 277 ATAKAEPRPAEETHVQVQPSTEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPP 336
Query: 990 RESVASGDDRAEEDMDEAIEKGEAEQSEEEA----DEEDKAEDAREEEYEPEKMEAEDYV 1045
+ + E + + E+ +E+ E E+ + + E P +A V
Sbjct: 337 SAEESPSVELLAEILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEV 396
Query: 1046 MAV-VDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEE 1104
+ + A E A+ + + + P P + L E+ A + E
Sbjct: 397 QPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTE 456
Query: 1105 NREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNE----ETESPSQEFV 1160
+ P+E TA + + ++EP + + R +S+ET+ E E +SP E
Sbjct: 457 FQSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAE-- 514
Query: 1161 NITKYESSLYSQ---EYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPS---SME 1214
T E+S Q PAD TP S S+ + + A A SP + S+E
Sbjct: 515 ETTAEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAE----EAPAEVQSPSAKGVSIE 570
Query: 1215 EDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSP----PSPLEKT 1270
E + +AS + + + A + E + + P +P P P E+
Sbjct: 571 EAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEA 630
Query: 1271 PLGERSVNFSLTPNEIK-VSAEAEVAPVSPEVTQEVVEEHCASP-EDKTLEVVS-PSQSV 1327
P + P E++ AE A V P +E E P E+ EV S P++
Sbjct: 631 PAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQSLPAEET 690
Query: 1328 ----TGSAGHTPYYQSPTDEKSSHLPTEVIEKPPA---VPVSFEFSDAKDENERASVSPM 1380
T +A H+P P D+ + + PPA + F +A E P
Sbjct: 691 PIEETLAAVHSP----PADDVPAEEASVDKHSPPADLLLTEEFPIGEASAEVS----PPP 742
Query: 1381 DEPVPDSESPIEKVLSPLRSPPLIG 1405
E P+ E+ +E V + +SP + G
Sbjct: 743 SEQTPEDEALVENVSTEFQSPQVAG 767
Score = 65.1 bits (157), Expect = 8e-10
Identities = 155/735 (21%), Positives = 275/735 (37%), Gaps = 79/735 (10%)
Query: 1069 TKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISS 1128
T ++G S + S+ E++ SE + T + ++ + E T+ S T + +E
Sbjct: 28 THRIGNTSGSKGSYSAKAYESIRVSSELQQTWTKRKHGQ----EMTSKSLQTDTIVEEKK 83
Query: 1129 EPTPMDEMSTPRDVMSD--ETNNEETESPSQEFV--NITKYESSL-YSQEYSKPADVTPL 1183
E ++E P + +D E E ES + NI + + SQ+ S+ T +
Sbjct: 84 EVKLVEETVVPEEKSADVREAAIELPESVQDVEIPPNIPSVQLKMDRSQQTSRTGYWTMM 143
Query: 1184 NGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSI 1243
N K D ++ S + K AL+ ++ AS + + +
Sbjct: 144 N-IPPVEKVDKEQQTYFSESEIVVISRPDSSSTKSKEDALKHKSSGKIFASEHPEFQPAT 202
Query: 1244 SA---VSSEKVS-PSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSP 1299
++ + + +S S + PP LE E +V + +K A AE+ P S
Sbjct: 203 NSNEEIGQKNISRTSFTQETKKGPPVLLEDELREEVTVPVVQEGSAVKKVASAEIEPPST 262
Query: 1300 E-----VTQEVVEEHCAS----PEDKTLEVVSPS-------QSVTGSAGHTPYYQSPTDE 1343
E + +VEE A P ++T V PS ++ T A ++ Q P E
Sbjct: 263 EKFPAKIQPPLVEEATAKAEPRPAEETHVQVQPSTEETPDAEAATAVAENSVKVQPPPAE 322
Query: 1344 KSS--HLPTEV----IEKPPAVPVSFEFSDAKDENERASVSPMDE-PVPDSESPIEKVLS 1396
++ P E+ E+ P+V + E E + P + P P +SP ++L
Sbjct: 323 EAPLVEFPAEIQPPSAEESPSVELLAEILPPSAEESPSEEPPAEILPPPAEKSPSVELLG 382
Query: 1397 PLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQ- 1455
+RSP S A + AE EE K P ++++ +
Sbjct: 383 EIRSP----------SAQKAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEA 432
Query: 1456 DKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKE 1515
++E + + E +E T E S P E ++
Sbjct: 433 PREEARELQLSTAMETPAEEAPT---EFQSPLPKETTAEEASAEIQLLAATEPPADETPA 489
Query: 1516 DTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLH 1575
+ + +SE T ++++ V +AE+T A ++A + + E D+
Sbjct: 490 EARSPLSEETSAEEAHAEVQSPLAEET------TAEEASAEIQLLAAIEAPADETP---- 539
Query: 1576 AEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTP- 1634
AE SP S E + + VQ+P+ S EE P + + PP TA+ +
Sbjct: 540 AEAQSPLSEETSAEEAPAEVQSPSA-----KGVSIEEAP--LELQPPSGEETTAEEASAA 592
Query: 1635 VQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHI-TENGPTEVDYSPSD 1693
+Q + ++S + P + Q P A V E P EV P++
Sbjct: 593 IQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAE 652
Query: 1694 MQDSSLSHKIPPMEE-PSYTQDNDLSELISVSQ---VEASP---STSSAHTPSQIASPLQ 1746
+ + PP EE P+ Q E + Q E +P + ++ H+P P +
Sbjct: 653 EAPAEVQP--PPAEEAPAEVQPPPAEEAPAEVQSLPAEETPIEETLAAVHSPPADDVPAE 710
Query: 1747 EDTLSDVAPPRDMSL 1761
E ++ +PP D+ L
Sbjct: 711 EASVDKHSPPADLLL 725
Score = 47.0 bits (110), Expect = 2e-04
Identities = 107/500 (21%), Positives = 183/500 (36%), Gaps = 46/500 (9%)
Query: 1343 EKSSHLPTEV--IEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRS 1400
E + LP V +E PP +P D + R M P + E+ S
Sbjct: 103 EAAIELPESVQDVEIPPNIPSVQLKMDRSQQTSRTGYWTMMNIPPVEKVDKEQQTYFSES 162
Query: 1401 PPLIGSESAYESFLSADD----KASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQD 1456
++ S S S +D K+SG+ S E S +++ ++ TS Q+
Sbjct: 163 EIVVISRPDSSSTKSKEDALKHKSSGKIFASEHPEFQPATNSNEEIGQ-KNISRTSFTQE 221
Query: 1457 KQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKED 1516
++G + ED +E+ T V S + V+ +I+ F
Sbjct: 222 TKKGPPV----LLEDELREEVTVPVVQEGSA---------VKKVASAEIEPPSTEKFPAK 268
Query: 1517 TKMSISEGTVSDKSATPVDEG---VAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPS 1573
+ + E + P +E V T + A+ + A + P P +
Sbjct: 269 IQPPLVEEATAKAEPRPAEETHVQVQPSTEETPDAEAATAVAENSVKVQPPPAEEAPLVE 328
Query: 1574 LHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDF------SPK 1627
AE+ P + E ++ + P+ + P E P P SP SP
Sbjct: 329 FPAEIQPPSAEESPSVELLAEILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPS 388
Query: 1628 TAKSRTPVQDHRSEQSSMSIEFGQESP--EQSLAMDFSRQSPDHPTVGAGVLHITENGPT 1685
K+ VQ +E + E P E++LA + P A L ++ T
Sbjct: 389 AQKAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMET 448
Query: 1686 EVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPL 1745
+ +P++ Q P+ P T + S I Q+ A+ + TP++ SPL
Sbjct: 449 PAEEAPTEFQS--------PL--PKETTAEEASAEI---QLLAATEPPADETPAEARSPL 495
Query: 1746 QEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRES-SPLYSPTFSDST 1804
E+T ++ A S A T+ + S E + L+ + TP E+ SPL T ++
Sbjct: 496 SEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEA 555
Query: 1805 SA-VKEKTATCHSSSSPPID 1823
A V+ +A S P++
Sbjct: 556 PAEVQSPSAKGVSIEEAPLE 575
Score = 45.1 bits (105), Expect = 9e-04
Identities = 138/733 (18%), Positives = 263/733 (35%), Gaps = 86/733 (11%)
Query: 1514 KEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTD-DVSP 1572
+E T S+ T+ ++ + + E+T E A V A++ PE D ++ P
Sbjct: 66 QEMTSKSLQTDTIVEEKK---EVKLVEETVVPEEKSADVREAAI---ELPESVQDVEIPP 119
Query: 1573 SLHA-EVGSPHSTEVDDS-----LSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSP 1626
++ + ++ S + + +++ V+ Q+T S S+ + IS PD S
Sbjct: 120 NIPSVQLKMDRSQQTSRTGYWTMMNIPPVEKVDKEQQTYFSESEI-----VVISRPDSSS 174
Query: 1627 KTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTE 1686
+K +D +SS I F E PE A + + + T+ GP
Sbjct: 175 TKSK-----EDALKHKSSGKI-FASEHPEFQPATNSNEEIGQKNISRTSFTQETKKGP-- 226
Query: 1687 VDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQ 1746
P ++D P+ Q+ + ++ +++E PST P++I PL
Sbjct: 227 ----PVLLEDELREEVTVPV-----VQEGSAVKKVASAEIEP-PSTEKF--PAKIQPPLV 274
Query: 1747 EDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLT---PRESSPLYS-PTFSD 1802
E+ + P + + ++ + E + ++ S P E +PL P
Sbjct: 275 EEATAKAEPRPAEETHVQVQPSTEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQ 334
Query: 1803 STSAVKEKTATCHSSSSPPI--DAASAEPYGFRASVLFDTMQHH--LALNRDLSTPGLEK 1858
SA + + + PP ++ S EP A +L + + L ++ +P +K
Sbjct: 335 PPSAEESPSVELLAEILPPSAEESPSEEP---PAEILPPPAEKSPSVELLGEIRSPSAQK 391
Query: 1859 DSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSD 1918
P A ++ P E+ +DV E+ R
Sbjct: 392 APIEVQPLPAEGALEEAPAKVEPPTVEE----------TLADVQPLLPEEAPREEARELQ 441
Query: 1919 SGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSYDISEKTTSPPEVSGYSYEKTE 1978
+ ET + T ++ + ++TT EE + T P + E
Sbjct: 442 LSTAMETPAEEAPT----EFQSPLPKETTA--EEASAEIQLLAATEPPAD------ETPA 489
Query: 1979 RSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTS 2038
+R L + ++ + + L + + + E + +I E + ET + ++P +
Sbjct: 490 EARSPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPAEA-QSPLSE 548
Query: 2039 TYCYETAEKITRTPQASTYSYETSDLCY---TAEKKSPSEARQDVDLCLVSSCEYKHPKT 2095
E A ++P A S E + L + E+ + EA + L +
Sbjct: 549 ETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAEEASAAIQLLAATEAS-----A 603
Query: 2096 ELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAP 2155
E +P+ + P P E E P E P ++ PP ++ + P
Sbjct: 604 EEAPAEVQPPPAE----EAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQ 659
Query: 2156 SQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDP-PPAPVQDRSPSPRH 2214
+ P E + P+ A A + S ET P ++T+ H P P ++ S
Sbjct: 660 PPPAEEAPAEVQPPPAEEAPAEVQSLPAEET-PIEETLAAVHSPPADDVPAEEASVDKHS 718
Query: 2215 PDVSMVDPEALAI 2227
P ++ E I
Sbjct: 719 PPADLLLTEEFPI 731
Score = 42.0 bits (97), Expect = 0.007
Identities = 95/513 (18%), Positives = 187/513 (36%), Gaps = 60/513 (11%)
Query: 1128 SEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFS 1187
+EP P +E ++ET + E + E N K + PA+ PL F
Sbjct: 281 AEPRPAEETHVQVQPSTEETPDAEAATAVAE--NSVKVQPP--------PAEEAPLVEFP 330
Query: 1188 EGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVS 1247
+ + + + I PPS+ E+ S + + S ++++ I + S
Sbjct: 331 AEIQPPSAEESPSVELLAEILPPSA--EESPSEEPPAEILPPPAEKSPSVELLGEIRSPS 388
Query: 1248 SEK----VSPSKSPSLSPSPPSPLEKTPLGERSVNFS-LTPNEIK------------VSA 1290
++K V P + P+ +E + E + L P E +
Sbjct: 389 AQKAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMET 448
Query: 1291 EAEVAPV---SPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSH 1347
AE AP SP + EE AS E + L P T + +P ++E S+
Sbjct: 449 PAEEAPTEFQSPLPKETTAEE--ASAEIQLLAATEPPADETPAEARSPL----SEETSAE 502
Query: 1348 LPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSE 1407
++ P A + E + A+ + A +P DE +++SP+ + S +P + S
Sbjct: 503 EAHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSP 562
Query: 1408 SAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAP 1467
SA S A + SG++ + ++ S ++ + + ++ P
Sbjct: 563 SA--------KGVSIEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPP 614
Query: 1468 IKEDFGQ------EKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSI 1521
+E + E+ +V+ ++ A A + + +P ++ + +
Sbjct: 615 AEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPP 674
Query: 1522 SEGTVSDKSATPVDEGVAEDTYS--HMEGVASVSTASVATSSFPEP-----TTDDVSPSL 1574
+E ++ + P +E E+T + H V + P T +
Sbjct: 675 AEEAPAEVQSLPAEETPIEETLAAVHSPPADDVPAEEASVDKHSPPADLLLTEEFPIGEA 734
Query: 1575 HAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMS 1607
AEV P S + + ++ V T FQ +++
Sbjct: 735 SAEVSPPPSEQTPEDEAL-VENVSTEFQSPQVA 766
Score = 35.4 bits (80), Expect = 0.70
Identities = 83/378 (21%), Positives = 130/378 (34%), Gaps = 76/378 (20%)
Query: 2085 VSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDE 2144
V+S E + P TE P+ I P PL EE T ++E + P +E
Sbjct: 252 VASAEIEPPSTEKFPAKIQP-PLV----EEATAKAEPRPAEETHVQVQPS-------TEE 299
Query: 2145 TPPTSVSESAPSQTDSDVPPETEECPSITADANID--SEDESETIP-----TDKTVTYKH 2197
TP + + + PP EE P + A I S +ES ++ +
Sbjct: 300 TPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAEILPPSAEESP 359
Query: 2198 MDPPPAPV---------------QDRSPSPRHPDVSM---------------VDP----E 2223
+ PPA + + RSPS + + + V+P E
Sbjct: 360 SEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAPAKVEPPTVEE 419
Query: 2224 ALAIEQNL-------GKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAG 2276
LA Q L +A + L +T T+ SP+ K + A A
Sbjct: 420 TLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQSPLPKETTAEEASAEIQLLAA 479
Query: 2277 LKESSDKV-SRVASPKKKE-SVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKT 2334
+ +D+ + SP +E S E+A +P + EE E + A A
Sbjct: 480 TEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETP 539
Query: 2335 ATAGPGTTKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGNDPAA 2394
A A ++ T + P + ++K V +E SG + A
Sbjct: 540 AEAQSPLSEETSAEEAPAEV----------QSPSAKGVSIE---EAPLELQPPSGEETTA 586
Query: 2395 EEPSRAV-LDALLEGKAQ 2411
EE S A+ L A E A+
Sbjct: 587 EEASAAIQLLAATEASAE 604
>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
Length = 3664
Score = 92.8 bits (229), Expect = 4e-18
Identities = 268/1330 (20%), Positives = 478/1330 (35%), Gaps = 211/1330 (15%)
Query: 525 VPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVE-SK 583
V P+V + K + A E KPA++P P+ V ++ V+ PP + K
Sbjct: 1663 VEAPLVTEEKTVEPATVSEEAKPASEPAPA------------PVEQLEQVDLPPGADPDK 1710
Query: 584 EKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETK 643
E M+ P E S + + P+P + + D +P + + +
Sbjct: 1711 EAAMM----PAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLS------ 1760
Query: 644 VKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKE 703
KP K EE +PK A+K D T + + +K E E + ++ + +P K +
Sbjct: 1761 -KPAQKSEEANEPK---AEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDK 1816
Query: 704 TPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKD-AKKSSTPLSEAKKPAALKPKVPKK 762
P K K+ + V EK ++ +++ ++ K+S++P EA+K LK + K
Sbjct: 1817 KPNKS-KRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKI 1875
Query: 763 EESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKE 822
+ K+S AA + + + + + +V A +G + V P ++
Sbjct: 1876 TRTASKNS-AADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKE--------PVEQ 1926
Query: 823 LEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKET-------EPVEA 875
R + L ++ +E A + P+ DEE+ E +P E
Sbjct: 1927 PRVTR------KRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEG 1980
Query: 876 YVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEP---VEKQGVDDIEKFEDEGAG 932
+ + ++ G +G + + + E+ P V++ ++ K +E AG
Sbjct: 1981 WRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSME--PKAAEEEAG 2038
Query: 933 FEESSETGDY------EEKAETEEAEE---PEEDGEEHVCVSASKHSPTEDEESAKAEAD 983
E+ + D E A E E+ PE++ + S + + S K D
Sbjct: 2039 SEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLK-NVD 2097
Query: 984 AYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEE-----------EADEEDKAEDAREE 1032
A + R + A +R + + EK E+ Q E+ + D+E + ED
Sbjct: 2098 AAV-SPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSAS 2156
Query: 1033 EYEPE------KMEAEDYVMAVVDKAAEAGG-----AEEQYGFLTTPTKQLGAQSPGREP 1081
PE +ME E V + K AEA A+ G + Q+ E
Sbjct: 2157 GPSPEATQLAKQMELEQAVEHIA-KLAEASASAAYKADAPEGLAPEDRDKPAHQASETEL 2215
Query: 1082 ASSIHD---------------ETLPGGSESE----ATASDEENREDQPEEFTATSGYTQS 1122
A++I PG S+++ A A + E+ E A SG ++
Sbjct: 2216 AAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILET 2275
Query: 1123 TIEISSEPTPM---DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD 1179
S P+ D + P D N+ ET E + E +L ++ +
Sbjct: 2276 EAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKT 2335
Query: 1180 -------------VTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDA 1226
V P+ S + N + P + EE + +
Sbjct: 2336 TRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPP 2395
Query: 1227 YCSEVKASTTLDIKDSISAVSSEKVSPSKS---PSLSPSP-PSPLEKTPLGERSVNFSLT 1282
S ++S +S E+ +P+K+ P L P P P+P+++ P V+ +
Sbjct: 2396 QSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIE 2455
Query: 1283 PNEIKVSAEAEV-APVSPEVTQEVVEEHCA-------SPEDKTLEVVSPSQSVTGSAGHT 1334
+ + ++ + P P VT + A SP K E ++ + A T
Sbjct: 2456 SDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEE--PRAQST 2513
Query: 1335 PYYQSPTDEKSSHLPT------EVIEKPPAVP----VSFEFSDAKDENERASVSPMDEPV 1384
P P D K+S + T +++ P V S + A E A+ + P
Sbjct: 2514 PSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPP 2573
Query: 1385 P--DSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQV 1442
P DS+ P+E+ +P P SE L A DK EK +P
Sbjct: 2574 PPVDSKKPLEEKTAP---PVTNNSEIQASEVLVAADK-----------EKVAPVIAPKIT 2619
Query: 1443 SPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSP 1502
S +S M P+ D +K + + Q L G V+
Sbjct: 2620 SVISRM------------------PVSIDLENSQKI-TLAKPAPQTLTGLVSALTGLVNV 2660
Query: 1503 TQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDE-GVAEDTYSHMEGVASVST----ASV 1557
+ + V+ + K K S++ T+ +TP V + + + G +V T A+V
Sbjct: 2661 SLVPVN---ALKGPVKGSVT--TLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATV 2715
Query: 1558 ATSSFPEPTTDDVSPSLHAEVGSPHSTE---VDDSLSVSVVQTPTTFQETEMSPSKEECP 1614
T + T + + +++A + T S V+ T ++PS +
Sbjct: 2716 GTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQ 2775
Query: 1615 RPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHP-TVG 1673
R + F P PV D R + + E + + +S Q + P +
Sbjct: 2776 RASANENSRFHP----GSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRIS 2831
Query: 1674 AGVLHITENGPTEVDY----SPSDMQDSSLSHKIPPMEEP----SYTQDNDLSELISVSQ 1725
A + I ++++ S S ++ S++ PP + P Y S L+ +Q
Sbjct: 2832 AKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQ 2891
Query: 1726 V-EASPSTSS 1734
ASP SS
Sbjct: 2892 TYNASPVISS 2901
Score = 74.3 bits (181), Expect = 1e-12
Identities = 266/1452 (18%), Positives = 514/1452 (35%), Gaps = 171/1452 (11%)
Query: 454 PNGQEVDLPISYLTSVSSLIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ 513
P E LP S +T + ++P + + + + + ++L ++L D +
Sbjct: 1288 PKVDEKVLPYSNITVREESLKFNPYDSSRR--EQMADMAKIKLSVLNSEDELNRWDSQMK 1345
Query: 514 PLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNH 573
A + D++ P ++K+ L++R S L+P P S E K +P + +
Sbjct: 1346 QDAGRFDVS--FPNSIIKRDSLRKR--SVRDLEPGEVPSDSDE-DGEHKSHSPRASAL-- 1398
Query: 574 VEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAA 633
ES + +D+ E K ++ + S E + + +K T KA
Sbjct: 1399 ------YESSRLSFLLRDR----EDKLRERDERLSSSLERNKFYSFALDKTITP-DTKAL 1447
Query: 634 KEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEK 693
E+ + + + + +DK + +P K+ K E K
Sbjct: 1448 LERAKSLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGK 1507
Query: 694 KEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKD-------------AK 740
+ KKE KE + + + + +++ + + +++ +D ++
Sbjct: 1508 MDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRIYGKQTSE 1567
Query: 741 KSSTPLSEAKKPAAL-KPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAV 799
+++ ++P L + + +K+ KPKE K + + K E+
Sbjct: 1568 GANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENK 1627
Query: 800 GTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLE 859
+ T + + + +L S+P L K + E VT++ +
Sbjct: 1628 DSELKTPPSVGPPSVTVV----------TLESAPSALEKTTGDKTVEAPLVTEEKTVEPA 1677
Query: 860 LIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEG---EGECEQTPEELEPVE 916
+ +E K +EP A V Q E +V P PD+ EG P L+
Sbjct: 1678 TVSEEAK-PASEPAPAPVEQLE-QVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLD--- 1732
Query: 917 KQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEE 976
K GA F ++ D E T+ +P + EE + P ++
Sbjct: 1733 -------AKPPTPGASFSQAESNVD-PEPDSTQPLSKPAQKSEE-------ANEPKAEKP 1777
Query: 977 SAKAEADAYIREKRESVASGDDRAEEDM---------DEAIEKGEAEQSEEEA---DEED 1024
A A+A+ +K E+ A ED+ D+ K + ++ +A +
Sbjct: 1778 DATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVE 1837
Query: 1025 KAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASS 1084
K + E + EK++ + K E E+ T +K A EP+
Sbjct: 1838 KPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEK--ITRTASKNSAADLEHPEPSLP 1895
Query: 1085 IHDETLPGGSESEATASDEENR---EDQPEEFTATSGYTQSTI-EISSEPTPMDEMSTPR 1140
+ AT D ENR ++ E+ T + + E ++ PT TPR
Sbjct: 1896 LSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPT------TPR 1949
Query: 1141 DVMSDETN---NEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDG 1197
+T +EE E+ ++E K S K T G +G K
Sbjct: 1950 RGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQK----TAAGGGPQGKKGKNEPK 2005
Query: 1198 KDYNASAST--ISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSK 1255
D +T + P ++E A + SE K D KD+ + + + +P +
Sbjct: 2006 VDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKR----DRKDAGTDKNPPETAPVE 2061
Query: 1256 SPSLSPSPPSPLEKTPLGE--------------RSVNFSLTPNEIKVSA---EAEVAPVS 1298
P+P K+ G ++V+ +++P A E+ V VS
Sbjct: 2062 VVEKKPAPEKN-SKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVS 2120
Query: 1299 PEVTQEVVEEHCASPEDKTLEV---VSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEK 1355
PE ++ +E S + K+ V P + ++G +P + E I K
Sbjct: 2121 PEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAK 2180
Query: 1356 PPAVPVSFEF-SDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFL 1414
S + +DA + ++P D P ++ ++ + + S +I S
Sbjct: 2181 LAEASASAAYKADAPE-----GLAPEDRDKPAHQASETELAAAIGS--IINDISGEPENF 2233
Query: 1415 SADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQ 1474
A G +++ + +G Q + + S + + + P+
Sbjct: 2234 PAPPPYPGE-SQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPS 2292
Query: 1475 EKKTDDVEAM--SSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSAT 1532
TD EA SS+ + ++ E K ++ + + ++ T S + + K
Sbjct: 2293 AGPTDTKEARGNSSETSHSVPEAK--GSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVA 2350
Query: 1533 PVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSV 1592
PV+ V E + E A+ +V PE +P + PHST S +
Sbjct: 2351 PVESHVPESNQAQGESPAANEGTTV---QHPE------APQEEKQSEKPHSTP-PQSCTS 2400
Query: 1593 SVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQE 1652
+ + P+T ++ +E P S+ PPD P + + + IE
Sbjct: 2401 DLSKIPSTENSSQEISVEERTPTKASV-PPDLPPPPQPAPVDEEPQARFRVHSIIESDPV 2459
Query: 1653 SPEQSLAMDF--------SRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQD----SSLS 1700
+P ++ ++ SP P G+ H ++ PT+V + ++ S+ S
Sbjct: 2460 TPPSDPSIPIPTLPSVTAAKLSP--PVASGGIPH--QSPPTKVTEWITRQEEPRAQSTPS 2515
Query: 1701 HKIPPMEEPS--YTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRD 1758
+PP + S T + L +++ + ++ S +S + IA P+ APP
Sbjct: 2516 PALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPP 2575
Query: 1759 MSLYASLTSEKVQSLEGEKLSPKSDISPLTPRES-SPLYSPTFSDSTSAVKEKTATCHSS 1817
+ L + + S++ +E +P+ +P TS + +
Sbjct: 2576 VDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKI---TSVISRMPVSIDLE 2632
Query: 1818 SSPPIDAASAEP 1829
+S I A P
Sbjct: 2633 NSQKITLAKPAP 2644
Score = 71.6 bits (174), Expect = 9e-12
Identities = 379/2000 (18%), Positives = 685/2000 (34%), Gaps = 333/2000 (16%)
Query: 559 KESKEETPEVTKVNHVEKPPKVESKEKVMVKKDK-----PIKTETKPSVTEKEVPSKEEP 613
+E + E E + E+ P S+ V +++ + P + E PS +E+ + S+
Sbjct: 702 RERERERFESDRDRDHERRPIERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSD 761
Query: 614 SPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKE- 672
+ K+ E+ K E K +KE+ + ++ I+KE
Sbjct: 762 RSGSCSSLSPPRYEKLDKSRLERYTKNE--------KTDKERTFDPERVERERRLIRKEK 813
Query: 673 -EKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEV----KKEVKKEEKKEVKKEEKE 727
EK K ++ K++ K + E +E ++E P++ K +K +K+ + K E
Sbjct: 814 VEKDKTDKQKRKGKVHSPSSQSSETDQENEREQSPEKPRSCNKLSREKADKEGIAKNRLE 873
Query: 728 --PKKEIKKLPKDAKK--SSTPLSEAK--------KPAALKPKV------PKKEESVKKD 769
P + ++ + K TP+ + K K +AL K+ P K + K +
Sbjct: 874 LMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLE 933
Query: 770 SVAAGKPKEKG---KIKVIKKEG-----KAAEAVAAAVGTGATTAAVMAA-------AGI 814
SV PKEKG ++V++KEG K + A G A + A + +
Sbjct: 934 SVRMKVPKEKGLSSHVEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNL 993
Query: 815 AAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVE 874
A E++ M L+K ++ + EV + ++ + + + + E +E++ ++
Sbjct: 994 KAEKQKPEVKKSSPEMEDARVLSKKQPDVSSREVILLREGEAERKPVRKEILKRESKKIK 1053
Query: 875 AYVI---------QKEREVTKGPAESPDEGITTTEGE--GEC--EQTPEELEPV-EKQGV 920
+ Q+ ++ G P + GE GE Q + +P+ K +
Sbjct: 1054 LDRLNTVASPKDCQELASISVGSGSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQL 1113
Query: 921 DDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPE-EDGEEHVCVSASKHSPTEDEESAK 979
++ +D+G E D + + E PE + G+E K EE
Sbjct: 1114 KQLQVLDDQG------PEREDVRKNYCSLRDETPERKSGQE-------KSHSVNTEEKIG 1160
Query: 980 AEAD---AYIREKRESVASGDDRAEEDMDEAIEKGEAEQS-EEEADEEDKAEDARE---- 1031
+ D +Y ++ +S R ++ M+ I K E S +++ DE ++ E
Sbjct: 1161 IDIDHTQSYRKQMEQS------RRKQQMEMEIAKSEKFGSPKKDVDEYERRSLVHEVGKP 1214
Query: 1032 -----EEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIH 1086
++ P K + D+V + E + ++ +++ G R S H
Sbjct: 1215 PQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQ--ISEDSERTGGSPSVRH--GSFH 1270
Query: 1087 DETLPGGSESEATASDEENREDQPEEFTATSGYTQSTI-EISSEPTPMDEMSTPRDVMSD 1145
++ P GS + + P+ Y+ T+ E S + P D S+ R+ M+D
Sbjct: 1271 EDEDPIGSPRLLSV------KGSPKVDEKVLPYSNITVREESLKFNPYD--SSRREQMAD 1322
Query: 1146 ETNNEETESPSQEFVNITKYESSLYSQ----EYSKPADVTPLNGFSEGSKTDATDGK--- 1198
+ + S++ +N +++S + + S P + + + S D G+
Sbjct: 1323 MAKIKLSVLNSEDELN--RWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSVRDLEPGEVPS 1380
Query: 1199 --DYNASASTISP-PSSMEEDKFSRSALRDAYCS----EVKASTTLDIKDSISAVSSEKV 1251
D + + SP S++ E LRD + + S++L+ S + +
Sbjct: 1381 DSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTI 1440
Query: 1252 SP------SKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEV 1305
+P ++ SLS S R NF ++ KV + P +++
Sbjct: 1441 TPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKI 1500
Query: 1306 VEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLP-TEVIEKPPAVPVSFE 1364
+ +DK + Q + S ++ S L E E+
Sbjct: 1501 RTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRI 1560
Query: 1365 FSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRG 1424
+ E ++ + EPV S + L+ ++ + E D + +
Sbjct: 1561 YGKQTSEGANSTTDSIQEPVVLFHSRFME-LTRMQQKEKEKDQKPKEVEKQEDTENHPKT 1619
Query: 1425 AESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAM 1484
ES E K + +P V P S T K+T ++ E+KT
Sbjct: 1620 PESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKT------ 1673
Query: 1485 SSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSA----TPVDEGVAE 1540
+PA +E K P V Q ++ + G DK A V+EG +
Sbjct: 1674 -VEPATVSEEAKPAS-EPAPAPVEQL------EQVDLPPGADPDKEAAMMPAGVEEGSSG 1725
Query: 1541 DTYSHMEGV-----ASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVV 1595
D +++ AS S A P+ T P+ +E + E D+ + +
Sbjct: 1726 DQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADA-- 1783
Query: 1596 QTPTTFQETEMSP-SKEECPRPMSISPP----DFSP-KTAKSRTPVQ------------- 1636
P Q+ E +P S+ + + PP D P K+ +S+TPVQ
Sbjct: 1784 -EPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTR 1842
Query: 1637 -DHRSEQSSMSIEFGQESPEQSL-------------AMDFSRQSPDHPTVGAGVLHITEN 1682
R ++ + Q L A S +HP +
Sbjct: 1843 KSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRR 1902
Query: 1683 GPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIA 1742
V + D ++ S + P+E+P T+ EL + V +P + A
Sbjct: 1903 NVRSVYATMGDHENRSPVKE--PVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRA 1960
Query: 1743 SPLQEDTLSDVA----PPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSP 1798
+E+ + A PP S + +G+K + + P E++ P
Sbjct: 1961 DEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRP-EATTEVGP 2019
Query: 1799 TFSDSTSAVKEKTATCHSSS-----------------SPPIDAASAEPYGFR--ASVLFD 1839
S+++ K A + S + P++ +P + S
Sbjct: 2020 QIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGR 2079
Query: 1840 TMQHHLALNRDLSTPGL--------------EKDSG------------GKTPGDFSYAYQ 1873
+ LA+++ S + E++SG K G S
Sbjct: 2080 SRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKS 2139
Query: 1874 KPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTK-SPSDSGYSYETIGKTTKT 1932
P + + P++ED + +E K + + + +Y+
Sbjct: 2140 DPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLA 2199
Query: 1933 PEDGDYSYEIIEKTTRTPEEGGYSYDIS---EKTTSPPEVSGYSYEKTERSRRLLDDISN 1989
PED D +T G DIS E +PP G S +
Sbjct: 2200 PEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQ----------- 2248
Query: 1990 GYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYETAEKIT 2049
G L ET E ++ E+E + E+S PD S T
Sbjct: 2249 ----PPAGAQALQPSEEGMETDEAVSGILETEA-ATESSRPPVNAPDPSA-------GPT 2296
Query: 2050 RTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPN---- 2105
T +A S ETS ++ ++V++ LV + KT S N N
Sbjct: 2297 DTKEARGNSSETS------HSVPEAKGSKEVEVTLVRK-DKGRQKTTRSRRKRNTNKKVV 2349
Query: 2106 -PLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDE---TPPTSVSESAPSQTDSD 2161
P+E E + E P G P Q+ +Q ++ TPP S + S
Sbjct: 2350 APVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDL-----SK 2404
Query: 2162 VPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPP-PAPVQDRSPSPRHPDVSMV 2220
+P I+ + E PT +V PP PAPV D P R S++
Sbjct: 2405 IPSTENSSQEISVE---------ERTPTKASVPPDLPPPPQPAPV-DEEPQARFRVHSII 2454
Query: 2221 DPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKES 2280
+ + + D T T K S PV P + P
Sbjct: 2455 ESDPV--------TPPSDPSIPIPTLPSVTAAKLSPPVASG---GIPHQSPP-------- 2495
Query: 2281 SDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKN--------AANASASKSA 2332
KV+ + +++ + P P+ KA+ + + +A + S S
Sbjct: 2496 -TKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSV 2554
Query: 2333 KTATAGPGTTKTTKSSAVPP 2352
TA A P + A PP
Sbjct: 2555 TTAIAEPVSAAPCLHEAPPP 2574
Score = 62.0 bits (149), Expect = 7e-09
Identities = 354/1898 (18%), Positives = 650/1898 (34%), Gaps = 343/1898 (18%)
Query: 515 LATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHV 574
L +K L + P V L ++ ++R+ + A L ++ + E K+ +PE+ +
Sbjct: 958 LKARKHLKPEQPADGVSAVDL-EKLEARKR-RFADSNLKAEKQKPEVKKSSPEMEDARVL 1015
Query: 575 -EKPPKVESKEKVMVKKD----KPIKTETKPSVTEK---------------------EVP 608
+K P V S+E +++++ KP++ E ++K V
Sbjct: 1016 SKKQPDVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVG 1075
Query: 609 SKEEPSP-VKAEVAEKQATDVKPKAAK-EKTVKKETKVKP----EDKKEEKEKPKKEVAK 662
S PS ++A + E V+ + + +K + + ++K +D+ E+E +K
Sbjct: 1076 SGSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCS 1135
Query: 663 KEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEE----- 717
D+TP +K + K V E K I + + +K++++ ++++ E+ K E
Sbjct: 1136 LRDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSP 1195
Query: 718 KKEVKK-EEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKP 776
KK+V + E + E+ K P+D S P S+ K+ + + K E + S +
Sbjct: 1196 KKDVDEYERRSLVHEVGKPPQDVTDDSPP-SKKKRMDHVDFDICTKRERNYRSSRQISED 1254
Query: 777 KEKGKIKVIKKEGKAAE--------AVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERS 828
E+ + G E + + G+ V+ + I E S
Sbjct: 1255 SERTGGSPSVRHGSFHEDEDPIGSPRLLSVKGSPKVDEKVLPYSNITV--------REES 1306
Query: 829 LMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGP 888
L +P D ++ + + D+ K +L ++ E++L + Q +++ +
Sbjct: 1307 LKFNPYDSSR-----REQMADMA---KIKLSVLNSEDELNRWDS------QMKQDAGRFD 1352
Query: 889 AESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAET 948
P+ I + + + K+ V D+E
Sbjct: 1353 VSFPNSII--------------KRDSLRKRSVRDLE----------------------PG 1376
Query: 949 EEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDE-- 1006
E + +EDGE HSP + +R++ + + D+R ++
Sbjct: 1377 EVPSDSDEDGEH------KSHSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNK 1430
Query: 1007 ----AIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQY 1062
A++K ++ + +REE + + +D +
Sbjct: 1431 FYSFALDKTITPDTKALLERAKSLSSSREENW------------SFLDWDSRFA------ 1472
Query: 1063 GFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPE--EFTATSGYT 1120
F K+ +P P+ + + + SE + E+++E++ E E A+
Sbjct: 1473 NFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLH 1532
Query: 1121 QSTIEISSEPTP-MDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD 1179
S E S+ ++ D +S ++T + + + L+ + +
Sbjct: 1533 SSIFEQDSKRLQHLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFME--- 1589
Query: 1180 VTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDI 1239
L + K K+ T + P + E ++ SE+K ++
Sbjct: 1590 ---LTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKD-------SELKTPPSVG- 1638
Query: 1240 KDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNE-----IKVSAEA-- 1292
S++ V+ E S PS LEKT G+++V L E VS EA
Sbjct: 1639 PPSVTVVTLE------------SAPSALEKT-TGDKTVEAPLVTEEKTVEPATVSEEAKP 1685
Query: 1293 --EVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPT 1350
E AP E ++V A P+ + + P+ GS+G P Y
Sbjct: 1686 ASEPAPAPVEQLEQVDLPPGADPDKEA--AMMPAGVEEGSSGDQPPY------------- 1730
Query: 1351 EVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAY 1410
+ KPP SF +++ +P PDS P+ K P SE A
Sbjct: 1731 -LDAKPPTPGASFSQAESN-----------VDPEPDSTQPLSK--------PAQKSEEAN 1770
Query: 1411 ESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVS---EMTSTSLYQDKQEGKS-TDFA 1466
E A+ + AE +K+ + +P+ P S E+ +DK+ KS
Sbjct: 1771 EP--KAEKPDATADAEPDANQKA--EAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKT 1826
Query: 1467 PIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTV 1526
P+ Q VE ++ + +D KL + + + + K + + T
Sbjct: 1827 PV-----QAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITR--TA 1879
Query: 1527 SDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEV 1586
S SA ++ H E +S T D E SP V
Sbjct: 1880 SKNSAADLE---------HPEPSLPLSRTRRRNVRSVYATMGD------HENRSPVKEPV 1924
Query: 1587 DDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMS 1646
+ V+ + QE P+ RP PKT + +++ +++ + +
Sbjct: 1925 EQP-RVTRKRLERELQEAAAVPTTPRRGRP---------PKTRRRADEEEENEAKEPAET 1974
Query: 1647 IE--FGQESPEQSLAM----DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLS 1700
++ G SP ++ + P V A T ++ S M+ +
Sbjct: 1975 LKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAE 2034
Query: 1701 HKI---PPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPR 1757
+ + D + E V VE P+ + S + A +
Sbjct: 2035 EEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLK 2094
Query: 1758 DMSLYASLTSEKVQSLEGEKLSPKSDISP---LTPRESSPLYSPTFSDSTSAVKEKTATC 1814
++ S Q+ GE+ S +SP +P++ L S SD KE
Sbjct: 2095 NVDAAVSPRGAAAQA--GERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKED 2152
Query: 1815 HSSSSPPIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGKTPGDFSYAYQK 1874
S+S P S E + + H+A + S S AY+
Sbjct: 2153 VSASGP-----SPEATQLAKQMELEQAVEHIAKLAEASA---------------SAAYKA 2192
Query: 1875 PEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGKTTKTPE 1934
+P++ D +T + +G + P+ Y E+ +T P
Sbjct: 2193 DAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGES--QTDLQPP 2250
Query: 1935 DGDYSYEIIEKTTRTPE--EGGYSYDISEKTTSPP-EVSGYSYEKTERSRRLLDDISNGY 1991
G + + E+ T E G + + +++ PP S T D
Sbjct: 2251 AGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPT--------DTKEAR 2302
Query: 1992 DDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYETAEK-ITR 2050
+S + H++ + S E ++T + +G + +T++ R +T+ E +
Sbjct: 2303 GNSSETSHSVPEAKGSKEV--EVTLVRKDKG--RQKTTRSRRKRNTNKKVVAPVESHVPE 2358
Query: 2051 TPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELS-PSFINPNPLEW 2109
+ QA S ++ ++P E +Q E H S S ++ P
Sbjct: 2359 SNQAQGESPAANEGTTVQHPEAPQEEKQS---------EKPHSTPPQSCTSDLSKIPSTE 2409
Query: 2110 FASEEPTEESEKPLTQS--GGAPPPPGGKQQGRQCDETPPT-----SVSESAPSQTDSDV 2162
+S+E + E P S PPPP Q DE P S+ ES P SD
Sbjct: 2410 NSSQEISVEERTPTKASVPPDLPPPP----QPAPVDEEPQARFRVHSIIESDPVTPPSDP 2465
Query: 2163 PPETEECPSITADANIDSEDESETIP--TDKTVTYKHMDPPPAPVQDRSPSPRHP---DV 2217
PS+TA A + S IP + T + + P +PSP P
Sbjct: 2466 SIPIPTLPSVTA-AKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKA 2524
Query: 2218 SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSD----------GKSKP 2267
S VD + + + L + T T + PV + KP
Sbjct: 2525 SDVDTSSSTLRKIL---MDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKP 2581
Query: 2268 LAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTT 2305
L P S + S V KE V P T
Sbjct: 2582 LEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKIT 2619
Score = 56.6 bits (135), Expect = 3e-07
Identities = 344/1911 (18%), Positives = 672/1911 (35%), Gaps = 360/1911 (18%)
Query: 640 KETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKP--------------KKEEVKKEVK 685
+E + +++ E+E+ + + + ++ PI++ + P + E + + +
Sbjct: 693 REYSYRQRERERERERFESDRDRDHERRPIERSQSPVHLRRPQSPGASPSQAERLPSDSE 752
Query: 686 KEI-------------------KKEEK-------KEPKKEVKKETPPKEVKKEVKKEEKK 719
+ + +K +K K K + ++ P+ V++E + K+
Sbjct: 753 RRLYSRSSDRSGSCSSLSPPRYEKLDKSRLERYTKNEKTDKERTFDPERVERERRLIRKE 812
Query: 720 EVKKEEKEPKKEIKKLPKDAKKSS-TPLSEAKKPAALKPKVPKK--EESVKKDSVAAGKP 776
+V+K++ + +K K+ + +SS T ++ + KP+ K E K+ +A +
Sbjct: 813 KVEKDKTDKQKRKGKVHSPSSQSSETDQENEREQSPEKPRSCNKLSREKADKEGIAKNRL 872
Query: 777 KEKGKI---KVIKKEGKA-----AEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERS 828
+ + +V +KEGK E + A + ++ + ++
Sbjct: 873 ELMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDTVKSSAL---------------DQKL 917
Query: 829 LMSSPEDLTKDFEELKAEEVDVTKD--IKPQLELIEDEEKLKETEPVEAYVIQKEREVTK 886
+S E D +L++ + V K+ + +E++E E +LK + ++
Sbjct: 918 QVSQTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKARKHLK------------ 965
Query: 887 GPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKA 946
E P +G++ + E+LE +++ D K E + ++SS E A
Sbjct: 966 --PEQPADGVSAVD--------LEKLEARKRRFADSNLKAEKQKPEVKKSSPE---MEDA 1012
Query: 947 ETEEAEEPEEDGEEHVCV--SASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDM 1004
++P+ E + + ++ P +E K E+ ++ +VAS D +E
Sbjct: 1013 RVLSKKQPDVSSREVILLREGEAERKPVR-KEILKRESKKIKLDRLNTVASPKD-CQELA 1070
Query: 1005 DEAIEKGEAEQSE------EEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGA 1058
++ G S+ E A E + ++ + ++ P K + + + + D+ E
Sbjct: 1071 SISVGSGSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQ-LQVLDDQGPEREDV 1129
Query: 1059 EEQYGFLTTPTKQLGAQSPGREPASSIHDETLPG----GSESEATASDEENREDQPEEFT 1114
+ Y L T + + G+E + S++ E G ++S ++ R+ Q E
Sbjct: 1130 RKNYCSLRDETPE---RKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEI 1186
Query: 1115 ATS---GYTQSTIEISSEPTPMDEM-STPRDVMSDETNNEETESPSQEFVNITKYESSLY 1170
A S G + ++ + + E+ P+DV D +++ +F TK E + Y
Sbjct: 1187 AKSEKFGSPKKDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERN-Y 1245
Query: 1171 SQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDK----FSRSALRD- 1225
D G + +D S +S S + D+ +S +R+
Sbjct: 1246 RSSRQISEDSERTGGSPSVRHGSFHEDEDPIGSPRLLSVKGSPKVDEKVLPYSNITVREE 1305
Query: 1226 ---------------AYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKT 1270
A +++K S L+ +D ++ S+ + +S P S +++
Sbjct: 1306 SLKFNPYDSSRREQMADMAKIKLS-VLNSEDELNRWDSQMKQDAGRFDVS-FPNSIIKRD 1363
Query: 1271 PLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASP---EDKTLEVVSPSQSV 1327
L +RSV L P E+ ++ + S + E D+ ++ + +
Sbjct: 1364 SLRKRSVR-DLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERL 1422
Query: 1328 TGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE-----------FSDAKDENERAS 1376
+ S +Y D+ + ++E+ ++ S E F++ ++ ++
Sbjct: 1423 SSSLERNKFYSFALDKTITPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNKDKEK 1482
Query: 1377 VSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESP-FEEKSGK 1435
V P+P +K+ + E E + + R S FE+ S +
Sbjct: 1483 VDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKR 1542
Query: 1436 QGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDER 1495
++ S+ S +Y GK T G TD ++ +P + R
Sbjct: 1543 LQHLERKEEDSDFISGRIY-----GKQT-------SEGANSTTDSIQ----EPVVLFHSR 1586
Query: 1496 KLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTA 1555
F E T+M E +K P + EDT +H + S
Sbjct: 1587 -----------------FMELTRMQQKE---KEKDQKPKEVEKQEDTENHPKTPESA--- 1623
Query: 1556 SVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSP--SKEEC 1613
P D VG P T V + S ++ TT +T +P ++E+
Sbjct: 1624 ---------PENKDSELKTPPSVGPPSVTVVTLESAPSALE-KTTGDKTVEAPLVTEEKT 1673
Query: 1614 PRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMD--FSRQSPDH-- 1669
P ++S + P + + PV+ + +E+ ++ S P +
Sbjct: 1674 VEPATVS-EEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLD 1732
Query: 1670 ---PTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKI--PPMEEPSYTQD-----NDLSE 1719
PT GA N E D + + + S + P E+P T D N +E
Sbjct: 1733 AKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAE 1792
Query: 1720 LISVSQVEAS-------PSTSSAHTPS---QIASPLQEDTLSDVAPPRDMSLYASLTSEK 1769
SQ AS P + P+ + +P+Q +S V P + K
Sbjct: 1793 AAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKP---------VTRK 1843
Query: 1770 VQSLEGEKL----SPKSDISPLTP-RESSPLYSPTFSDSTSAVKEKTATCHSSSSPPIDA 1824
+ ++ EKL SP+ + L + + + T S +++A E H S P+
Sbjct: 1844 SERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLE-----HPEPSLPLSR 1898
Query: 1825 ASAEPYGFRASVLFDTMQHHLALNRD----------LSTPGLEKDSGGKTPGDFSYAYQK 1874
++ TM H NR ++ LE++ + +
Sbjct: 1899 TRRR----NVRSVYATMGDH--ENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGR 1952
Query: 1875 PEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGKTTKTPE 1934
P +T R DEE+ + E+ E G+ + ++T G + K T
Sbjct: 1953 PPKTRRRADEEE-ENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRP 2011
Query: 1935 DGDYSYEIIEKTTRTPEEGGYSYDISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYDDS 1994
E TT E G + E + P + + +R R+
Sbjct: 2012 ---------EATT----EVGPQIGVKESSMEPKAAEEEAGSEQKRDRK------------ 2046
Query: 1995 EDGGHTLGDPSYS-YETTEKITSFPESEGYSYETSTKTTR-TPDTSTYCYETAEKITRTP 2052
D G P + E EK + PE S ++ +R D S ++
Sbjct: 2047 -DAGTDKNPPETAPVEVVEKKPA-PEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRG 2104
Query: 2053 QASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFAS 2112
A+ S + + +KS S ++D LS S + +P+
Sbjct: 2105 AAAQAGERESGVVAVSPEKSESPQKED----------------GLS-SQLKSDPV----- 2142
Query: 2113 EEPTEESEKPLTQSGGAPPPPGGKQQGRQCD---------ETPPTSVSESAPSQTDSDVP 2163
+P +E EK + G P P Q +Q + + S S + + +
Sbjct: 2143 -DPDKEPEKEDVSASG--PSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLA 2199
Query: 2164 PETEECPSITADAN----------IDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPR 2213
PE + P+ A D E E P PPP P + ++
Sbjct: 2200 PEDRDKPAHQASETELAAAIGSIINDISGEPENFPA----------PPPYPGESQTDLQP 2249
Query: 2214 HPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSS----PVKKSDGKSKPLA 2269
+ P +E + + + + T++ +P S K++ G S +
Sbjct: 2250 PAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETS 2309
Query: 2270 AS-PKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASA 2328
S P+ G KE +V+ V K ++ ++ + T + A E E+ A S
Sbjct: 2310 HSVPEAKGSKEV--EVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESP 2367
Query: 2329 SKSAKTATAGPGTTKTTKSSAVPPGLP---VYLDLCYIPNHSN-SKNVDVE 2375
+ + T P + K S P P DL IP+ N S+ + VE
Sbjct: 2368 AANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVE 2418
Score = 42.4 bits (98), Expect = 0.006
Identities = 51/231 (22%), Positives = 91/231 (39%), Gaps = 37/231 (16%)
Query: 2129 APPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIP 2188
APPP G+ Q D PP PS+ ET+E +++ ++ ES P
Sbjct: 2235 APPPYPGESQ---TDLQPPAGAQALQPSEEGM----ETDE--AVSGILETEAATESSRPP 2285
Query: 2189 TDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKT--- 2245
+ DP P + + S PEA ++ ++KD K + KT
Sbjct: 2286 VNAP------DPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKD-KGRQKTTRS 2338
Query: 2246 -KKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTT 2304
+K T K +PV+ + S + G ++++ + V P+ + +++ KP +
Sbjct: 2339 RRKRNTNKKVVAPVESH------VPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHS 2392
Query: 2305 TPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVPPGLP 2355
TP K T+N++ + + +T ++VPP LP
Sbjct: 2393 TPPQSCTSDLSKIPSTENSSQEISVEE-----------RTPTKASVPPDLP 2432
Score = 40.4 bits (93), Expect = 0.022
Identities = 64/286 (22%), Positives = 97/286 (33%), Gaps = 27/286 (9%)
Query: 2084 LVSSCEYK-HPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQC 2142
LV EY+ HP T P + T SE+P G PP K +
Sbjct: 3178 LVMQSEYRLHPYTV-------PRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPG 3230
Query: 2143 DETPPTSVSESAPSQTDSDVP---PETEECPSITADANI---DSEDESETIPTDKTVTYK 2196
E T +++AP+ T + VP P P+ +A I ++ + +P V
Sbjct: 3231 KEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVT 3290
Query: 2197 HMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSS 2256
H + R+ D+ P A A L +TKT G +
Sbjct: 3291 HGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPE-GE 3349
Query: 2257 PVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEK 2316
P++ A P P + + S K + V + AK T T G E+
Sbjct: 3350 PLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQ-VSQEAKGTQT-------GVEQ 3401
Query: 2317 DKETKNAANASASKSAKT----ATAGPGTTKTTKSSAVPPGLPVYL 2358
+ AN + A GP + + S ++ P LPV L
Sbjct: 3402 PRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSL 3447
>gi|239743293 PREDICTED: mucin 12 [Homo sapiens]
Length = 5478
Score = 92.4 bits (228), Expect = 5e-18
Identities = 294/1405 (20%), Positives = 461/1405 (32%), Gaps = 212/1405 (15%)
Query: 1057 GAEEQYGFLTTPTKQLGAQSPGR---EPASS----IHDETLPGGSESEATA---SDEENR 1106
G+ E F TPT + + P PAS+ +++ G E+TA S +
Sbjct: 2392 GSTETTVFPRTPTTSVRGEEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQ 2451
Query: 1107 EDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMS-----------DETNNEETESP 1155
P T +ST SS + +S R S ++ E T P
Sbjct: 2452 TGLPATLTTADLGEESTTFPSSSGSTGTTLSPARSTTSGLVGESTPSRLSPSSTETTTLP 2511
Query: 1156 -SQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSME 1214
S ++++ ++ Y+ S A ++P S G +++ S T + P S
Sbjct: 2512 GSPTTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTT 2571
Query: 1215 EDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPL-- 1272
SR + +T L + S S E + SP + + SP T L
Sbjct: 2572 TPGLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSPGSTDTALSPGSTTALSF 2631
Query: 1273 GERSVNFSLTPNE---------------IKVSAEAEVAPVSPEVTQEVVEEHCASP---- 1313
G+ S F +P ++ S + SP T SP
Sbjct: 2632 GQESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASS--TSPGLQG 2689
Query: 1314 EDKTLEV------VSPSQSVTGSAG---HTPYYQSPTDEKSSHLPTEVI-----EKPPAV 1359
E T + +PS T +A T Y++SP ++H P EK
Sbjct: 2690 ESTTFQTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIF 2749
Query: 1360 PVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLR-SPPLIGSESAYESFLS--- 1415
S + S + ++ S E SP ++ L S G A +F S
Sbjct: 2750 HSSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPR 2809
Query: 1416 --------ADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMT------STSLYQDKQEGK 1461
A + G G ES +S + VSP S T ST++Y
Sbjct: 2810 SPTTTLSPASMTSLGVGEEST-TSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGST 2868
Query: 1462 STDFAPIKEDF---GQEKKTDDVEAMSSQPALALDERKLGDVS------PTQIDVSQFGS 1512
T P G+E T S+ L ++ ++ P +Q G
Sbjct: 2869 ETTVFPRSTTTSVRGEEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGL 2928
Query: 1513 FKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTT---DD 1569
T + E + + S++ S G+ ST S + S E TT
Sbjct: 2929 PATLTTADLGEESTTFPSSSGSTGTTLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSP 2988
Query: 1570 VSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTA 1629
+PSL + + +++ ++S T ++ E S S + + + PD + +
Sbjct: 2989 TTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSG 3048
Query: 1630 KSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDY 1689
S+ P H S+ S+ + SP + A +QS H + G TE
Sbjct: 3049 LSQEPTASHSSQGSTEA----TLSPGSTTASSLGQQST--------TFH-SSPGDTETTL 3095
Query: 1690 SPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHT----PSQIASPL 1745
P D S L P ST S HT S ++ L
Sbjct: 3096 LPDDTITSGLVEASTPTHS----------------------STGSLHTTLTPASSTSAGL 3133
Query: 1746 QEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPT--FSDS 1803
QE++ + + P +S+ S G +P + T S P +PT FS S
Sbjct: 3134 QEESTTFQSWPS--------SSDTTPSPPGTTAAP---VEVSTTYHSRPSSTPTTHFSAS 3182
Query: 1804 TSAV--KEKTATCHSSSSPPIDAASAEPYGFRASVLF---DTMQHHLALNRDLSTPGLEK 1858
++ + E++ T H SSP + P SVL T + PG
Sbjct: 3183 STTLGRSEESTTVH--SSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTT 3240
Query: 1859 DSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSP-- 1916
+G Y+ + +TT SP S E TT S G + +T P
Sbjct: 3241 TAGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGV 3300
Query: 1917 -SDSGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSYDISEKTTSPPEVSGYSYE 1975
+S S+ + G T T G + + + T G S +E T P +
Sbjct: 3301 SQESTASHSSPGSTDTTLSPGSTTASSLGPESTTFHSGPGS---TETTLLPDNTTASG-- 3355
Query: 1976 KTERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTP 2035
L + S S HT P+ S + T+F S+ S TT P
Sbjct: 3356 --------LLEASTPVHSSTGSPHTTLSPAGSTTRQGESTTF-----QSWPNSKDTTPAP 3402
Query: 2036 DTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKT 2095
T+T + +++ T S S T+ ++ SE V V++ P
Sbjct: 3403 PTTTSAF---VELSTTSHGSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPAR 3459
Query: 2096 ELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAP--PPPGGKQQGRQCDETPPTSVSES 2153
+ + E T S TQ+ P G+ + + T S
Sbjct: 3460 STTSGLV---------EESTTYHSSPGSTQTMHFPESDTTSGRGEESTTSHSSTTHTISS 3510
Query: 2154 APSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPR 2213
APS T + V T S + A D S T + T H S +
Sbjct: 3511 APSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASH-------------SSQ 3557
Query: 2214 HPDVSMVDPEALAIEQNLGKALKKDLKEKT--KTKKPGTKTKSSSPVKKSDGKSKPL--A 2269
++V P LG++ + + T PG+ T K + S P A
Sbjct: 3558 DATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTFHSSPRSPA 3617
Query: 2270 ASPKPAGLKESSDKVSRVASPKKKESVEKAAKP--TTTPEVKAARGEEKDKETKNAANAS 2327
+ PA S S + S A P TTTP G + T +++ S
Sbjct: 3618 TTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDSTTTP------GLSRHSTTSHSSPGS 3671
Query: 2328 ASKS---AKTATAGPGTTKTTKSSA 2349
+ A T T+G TT S+
Sbjct: 3672 TDTTLLPASTTTSGSSQESTTSHSS 3696
Score = 90.9 bits (224), Expect = 1e-17
Identities = 319/1513 (21%), Positives = 495/1513 (32%), Gaps = 220/1513 (14%)
Query: 897 TTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEE 956
+TT G E E T PV + G EES T + T+ PE
Sbjct: 3432 STTLGRSE-ESTTVHSSPVATATTPSPARSTTSGL-VEES--TTYHSSPGSTQTMHFPES 3487
Query: 957 D-----GEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVAS-GDDRAEEDMDEAIEK 1010
D GEE + S S T SA + A + E +S G D +
Sbjct: 3488 DTTSGRGEES---TTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTS 3544
Query: 1011 GEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQY--GFLTTP 1068
G +E+S ++DA P + + +G E G TTP
Sbjct: 3545 GRSEESTAS----HSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTP 3600
Query: 1069 ---TKQLGAQSPGREPASSIHD-ETLPGGSESEATASDEENREDQPEEF---TATSGYTQ 1121
K S R PA+++ T G E+T S F T T G ++
Sbjct: 3601 GLSEKSTTFHSSPRSPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDSTTTPGLSR 3660
Query: 1122 STIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVT 1181
+ S P D P + ++ E T T + SS + P T
Sbjct: 3661 HSTTSHSSPGSTDTTLLPASTTTSGSSQEST----------TSHSSSGSTDTALSPGSTT 3710
Query: 1182 PLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKD 1241
L+ E + ++ G + +T+ P S+ S + S TTL
Sbjct: 3711 ALSFGQESTTFHSSPGSTH----TTLFPDSTTSSGIVEASTR--VHSSTGSPRTTLSPAS 3764
Query: 1242 SIS-AVSSEKVSPSKSPS---LSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPV 1297
S S + E + P+ +PSPPS T E S + +P + +
Sbjct: 3765 STSPGLQGESTAFQTHPASTHTTPSPPSTA--TAPVEESTTYHRSPGSTPTTHFPASSTT 3822
Query: 1298 SPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPP 1357
S + + +SP+ S + +G T SP + + LP
Sbjct: 3823 SGHSEKSTIFH--SSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGL 3880
Query: 1358 AVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSAD 1417
+ + +S + S + M ES RS P S + + A
Sbjct: 3881 SEASTTFYSSPRSPTTTLSPASMTSLGVGEESTTS------RSQP----GSTHSTVSPAS 3930
Query: 1418 DKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDK-----QEGKSTDFAPIKEDF 1472
G ES S + V P S T+TS+ +++ ST ED
Sbjct: 3931 TTTPGLSEESTTVYSSSPGSTETTVFPRS--TTTSVRREEPTTFHSRPASTHTTLFTEDS 3988
Query: 1473 GQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSAT 1532
T++ A PA + G P + + G +E T S G+ K +
Sbjct: 3989 TTSGLTEESTAFPGSPA----STQTG--LPATLTTADLG--EESTTFPSSSGSTGTKLSP 4040
Query: 1533 PVDEGVAEDTYSHMEGVAS---VSTASVATSSFP-EPTTDDVSPSLHAEVGSPHSTEVDD 1588
A T S + G ++ +S +S T++ P PTT +S SP S +
Sbjct: 4041 ------ARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDA-- 4092
Query: 1589 SLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIE 1648
++S T ++ E S S + + + PD + + S+ P H S+ S+ +
Sbjct: 4093 --TLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTTSHSSQGSTEA-- 4148
Query: 1649 FGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEE 1708
SP + A +QS H + G TE P D S L P
Sbjct: 4149 --TLSPGSTTASSLGQQST--------TFH-SSPGDTETTLLPDDTITSGLVEASTPTHS 4197
Query: 1709 ----------PSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRD 1758
P+ + L E + Q S S ++ PS A P++ T P
Sbjct: 4198 STGSLHTTLTPASSTSTGLQEESTTFQSWPSSSDTTPSPPSTTAVPVEVSTTYHSRPSST 4257
Query: 1759 MSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSS 1818
+ + S +S + S +S +P + PT S ++ V E T +
Sbjct: 4258 PTTHFSASSTTLGR------SEESTTVHSSPGATGTALFPTRSATSVLVGEPTTS----- 4306
Query: 1819 SPPIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGKTPGDFSYAYQKPEET 1878
PI + S E AL +T GL + S Y+ + +T
Sbjct: 4307 --PISSGSTET---------------TALPGSTTTAGLSEKS------TTFYSSPRSPDT 4343
Query: 1879 TRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSP---SDSGYSYETIGKTTKTPED 1935
T SP S E TT S G + +T P +S S+ + G T T
Sbjct: 4344 TLSPASTTSSGVSEESTTSHSRPGSMHTTAFPSSTTMPGVSQESTASHSSPGSTDTTLSP 4403
Query: 1936 GDYSYEII--EKTTRTPEEGGYSYDISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYDD 1993
G + + E TT G S +TT P + T S L + S
Sbjct: 4404 GSTTASSLGPESTTFHSSPG------STETTLLP-------DNTTASGLL--EASTPVHS 4448
Query: 1994 SEDGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYETAEKITRTPQ 2053
S HT P+ S + T+F S+ S TT P T+T + +++ T
Sbjct: 4449 STGSPHTTLSPAGSTTRQGESTTF-----QSWPNSKDTTPAPPTTTSAF---VELSTTSH 4500
Query: 2054 ASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASE 2113
S S T+ ++ SE V V++ P + + E
Sbjct: 4501 GSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLV---------EE 4551
Query: 2114 EPTEESEKPLTQSGGAPP--PPGGKQQGRQCDETPPTSVSESAPSQTDS--DVPPETEEC 2169
T S TQ+ P G+ + + T SAPS T + + P
Sbjct: 4552 STTYHSSPGSTQTMHFPESNTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSS 4611
Query: 2170 PSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQ 2229
P TA + + + T ++ D V P S++ E+
Sbjct: 4612 PGSTATTHFPDSSTTSGRSEESTASHSSQDATGTIV-----LPARSTTSVLLGESTTSPI 4666
Query: 2230 NLGKALKKDLKEKTKTKKPGTKTK--------SSSPVKKSDGKSKPLAASPKPAGLKESS 2281
+ G L T T PG K SS+P S L S + + S
Sbjct: 4667 SSGSMETTALPGSTTT--PGLSEKSTTFHSSPSSTPTTHFSASSTTLGRSEESTTVHSSP 4724
Query: 2282 DKVSRVASPKK-------KESVEKAAKPTTT-----PEVKAARGEEKDKETKNAANASAS 2329
+ SP + +ES + P +T PE A G ++ T S S
Sbjct: 4725 VATATTPSPARSTTSGLVEESTAYHSSPGSTQTMHFPESSTASGRSEESRT------SHS 4778
Query: 2330 KSAKTATAGPGTT 2342
+ T ++ P TT
Sbjct: 4779 STTHTISSPPSTT 4791
Score = 90.5 bits (223), Expect = 2e-17
Identities = 313/1472 (21%), Positives = 490/1472 (33%), Gaps = 208/1472 (14%)
Query: 931 AGFEESSETGDYEEKAETEEAEEPEED-----GEEHVCVSASKHSPTEDEESAKAEADAY 985
+G E S T + T+ PE D GEE + S S T SA + A
Sbjct: 823 SGLVEESTTY-HSSPGSTQTMHFPESDTTSGRGEES---TTSHSSTTHTISSAPSTTSAL 878
Query: 986 IREKRESVAS-GDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDY 1044
+ E +S G D + G +E+S ++DA P +
Sbjct: 879 VEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTAS----HSSQDATGTIVLPARSTTSVL 934
Query: 1045 VMAVVDKAAEAGGAEEQY--GFLTTP---TKQLGAQSPGREPASSIHD-ETLPGGSESEA 1098
+ +G E G TTP + S R PA+++ T G E+
Sbjct: 935 LGESTTSPISSGSMETTALPGSTTTPGLSERSTTFHSSPRSPATTLSPASTTSSGVSEES 994
Query: 1099 TASDEENREDQPEEF---TATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESP 1155
T S F T T G ++ + S P D P T P
Sbjct: 995 TTSRSRPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTT--------TSGP 1046
Query: 1156 SQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEE 1215
SQE + T + SS + P T L+ E + + G + +T+ P S+
Sbjct: 1047 SQE--STTSHSSSGSTDTALSPGSTTALSFGQESTTFHSNPGSTH----TTLFPDSTTSS 1100
Query: 1216 DKFSRSALRDAYCSEVKASTTLDIKDSIS-AVSSEKVSPSKSPS---LSPSPPSPLEKTP 1271
S + S TTL S S + E + P+ +PSPPS T
Sbjct: 1101 GIVEASTR--VHSSTGSPRTTLSPASSTSPGLQGESTAFQTHPASTHTTPSPPSTA--TA 1156
Query: 1272 LGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSA 1331
E S + +P + + S + + +SP+ S + +G
Sbjct: 1157 PVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFH--SSPDASGTTPSSAHSTTSGRG 1214
Query: 1332 GHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPI 1391
T SP + + LP + + +S + S + M ES
Sbjct: 1215 ESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEESTT 1274
Query: 1392 EKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTST 1451
RS P S + + A G ES S + + V P S T+T
Sbjct: 1275 S------RSQP----GSTHSTVSPASTTTPGLSEESTTVYSSSRGSTETTVFPHS--TTT 1322
Query: 1452 SLYQDK-----QEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQID 1506
S++ ++ ST ED T++ A PA + G P +
Sbjct: 1323 SVHGEEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPGSPA----STQTG--LPATLT 1376
Query: 1507 VSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVAS---VSTASVATSSFP 1563
+ G +E T S G+ K + A T S + G ++ +S +S T++ P
Sbjct: 1377 TADLG--EESTTFPSSSGSTGTKLSP------ARSTTSGLVGESTPSRLSPSSTETTTLP 1428
Query: 1564 -EPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPP 1622
PTT +S SP S + ++S T ++ E S S + + + P
Sbjct: 1429 GSPTTPSLSEKSTTFYTSPRSPDA----TLSPATTTSSGVSEESSTSHSQPGSTHTTAFP 1484
Query: 1623 DFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITEN 1682
D + + S+ P H S+ S+ + SP + A +QS H +
Sbjct: 1485 DSTTTSDLSQEPTTSHSSQGSTEA----TLSPGSTTASSLGQQST--------TFH-SSP 1531
Query: 1683 GPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHT----P 1738
G TE P D S L P ST S HT
Sbjct: 1532 GDTETTLLPDDTITSGLVEASTPTHS----------------------STGSLHTTLTPA 1569
Query: 1739 SQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSP 1798
S ++ LQE++ + + P +S+ S G +P + T S P +P
Sbjct: 1570 SSTSAGLQEESTTFQSWPS--------SSDTTPSPPGTTAAP---VEVSTTYHSRPSSTP 1618
Query: 1799 T--FSDSTSAV--KEKTATCHSSSSPPIDAASAEPYGFRASVLF---DTMQHHLALNRDL 1851
T FS S++ + E++ T H SSP + P SVL T
Sbjct: 1619 TTHFSASSTTLGRSEESTTVH--SSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETT 1676
Query: 1852 STPGLEKDSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIER 1911
+ PG +G Y+ + +TT SP S E TT S G +
Sbjct: 1677 ALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPG 1736
Query: 1912 TTKSP---SDSGYSYETIGKTTKTPEDGDYSYEII--EKTTRTPEEGGYSYDISEKTTSP 1966
+T P +S S+ + G T T G + + E TT G S +TT
Sbjct: 1737 STTMPGVSQESTASHSSPGSTDTTLSPGSTTASSLGPESTTFHSSPG------STETTLL 1790
Query: 1967 PEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYE 2026
P + T S L + S S HT P+ S + T+F S+
Sbjct: 1791 P-------DNTTASGLL--EASTPVHSSTGSPHTTLSPAGSTTRQGESTTF-----QSWP 1836
Query: 2027 TSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVS 2086
+S T P T+T + +++ T S S T+ ++ SE V V+
Sbjct: 1837 SSKDTMPAPPTTTSAF---VELSTTSHGSPSSTPTTHFSASSTTLGRSEESTTVHSSPVA 1893
Query: 2087 SCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETP 2146
+ P + + + + +S T+ P + + G+ + + +
Sbjct: 1894 TATTPSPARSTTSGLVEES-TAYHSSPGSTQTMHFPESSTA------SGRSEESRTSHSS 1946
Query: 2147 PTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQ 2206
T S PS T + V T S + A D S T + T H
Sbjct: 1947 TTHTISSPPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASH--------- 1997
Query: 2207 DRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKT--KTKKPGTKTKSSSPVKKSDGK 2264
S + ++V P LG++ + + T PG+ T K +
Sbjct: 1998 ----SSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTFH 2053
Query: 2265 SKPL--AASPKPAGLKESSDKVSRVASPKKKESVEKAAKP--TTTPEVKAARGEEKDKET 2320
S P A + PA S S + S A P TTTP G + T
Sbjct: 2054 SSPRSPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDSTTTP------GLSRHSTT 2107
Query: 2321 KNAANASASKS---AKTATAGPGTTKTTKSSA 2349
+++ S + A T T+GP TT S+
Sbjct: 2108 SHSSPGSTDTTLLPASTTTSGPSQESTTSHSS 2139
Score = 80.5 bits (197), Expect = 2e-14
Identities = 283/1367 (20%), Positives = 440/1367 (32%), Gaps = 203/1367 (14%)
Query: 1090 LPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNN 1149
LP ++ A + E+ R++ + SG++Q T ST + T +
Sbjct: 132 LPLSEQARAAGAREKERQETVINHSTFSGFSQIT------------GSTVNTSIGGNTTS 179
Query: 1150 EETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISP 1209
T S S F + Y S+ S + + G ++T + T
Sbjct: 180 ASTPSSSDPFTTFSDYGVSVTFITGSTATKHFLDSSTNSGHSEESTVSHSGPGATGTTLF 239
Query: 1210 PSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEK 1269
PS F S +T L + + +S + + SP SP
Sbjct: 240 PSHSATSVFVGEPKTSPITSASMETTALPGSTTTAGLSEKSTTFYSSPRSPDRTLSPART 299
Query: 1270 TPLG--ERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSV 1327
T G E+S P A + + P V+QE H S T +SP +
Sbjct: 300 TSSGVSEKSTTSHSRPGPTHTIAFPD-STTMPGVSQESTASH--SIPGSTDTTLSPGTTT 356
Query: 1328 TGSAG--HTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVP 1385
S G T ++ SP K++ LP D + + PV
Sbjct: 357 PSSLGPESTTFHSSPGYTKTTRLP--------------------DNTTTSGLLEASTPVH 396
Query: 1386 DSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPV 1445
S LSP S G + ++S+ S+ D + +P +
Sbjct: 397 SSTGSPHTTLSPSSSTTHEGEPTTFQSWPSSKDTSP----------------APSGTTSA 440
Query: 1446 SEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQI 1505
ST+ + +T F+ G +++ V SS A A +P
Sbjct: 441 FVKLSTTYHSSPSSTPTTHFSASSTTLGHSEESTPVH--SSPVATA--------TTPPPA 490
Query: 1506 DVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVAT-SSFPE 1564
+ G +E T S G S + + T H E A+ ++ T SS P
Sbjct: 491 RSATSGHVEESTAYHRSPG-----STQTMHFPESSTTSGHSEESATFHGSTTHTKSSTPS 545
Query: 1565 PTTDDVSPSLHAEVGSPHSTEVDDSLSVS----------------------VVQTPTTF- 1601
T S H+ +GS +T DS ++S TP+
Sbjct: 546 TTAALAHTSYHSSLGSTETTHFRDSSTISGRSEESKASHSSPDAMATTVLPAGSTPSVLV 605
Query: 1602 QETEMSP----SKEECPRPMSISPPDFSPKT----AKSRTPVQDHRSEQSSMSIEFGQES 1653
++ SP S E P S + P S K+ + R+P H + S
Sbjct: 606 GDSTPSPISSGSMETTALPGSTTKPGLSEKSTTFYSSPRSPDTTHLPASMTSS------G 659
Query: 1654 PEQSLAMDFSRQSPDHPTVGAGVLHI-----------TENGPTEVDYSPSDMQDSSLS-- 1700
+ SR H T G + + GPT+ SP SSL
Sbjct: 660 VSEESTTSHSRPGSTHTTAFPGSTTMPGLSQESTASHSSPGPTDTTLSPGSTTASSLGPE 719
Query: 1701 ----HKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIAS------------- 1743
H P E + DN + + + + ST S HT A
Sbjct: 720 YTTFHSRPGSTETTLLPDNTTASGLLEASMPVHSSTRSPHTTLSPAGSTTRQGESTTFHS 779
Query: 1744 -PLQEDTLSDVAPPRDMSLYA--SLTSE-KVQSLEGEKLSPKSDISPL----TPRESSPL 1795
P +DT APP S + S TS S+ +S +S S L T SSP
Sbjct: 780 WPSSKDTRP--APPTTTSAFVEPSTTSHGSPSSIPTTHISARSTTSGLVEESTTYHSSPG 837
Query: 1796 YSPTF----SDSTSAVKEKTATCHSSSSPPIDAASAEPYGFRASVLFDTMQHHLALNRDL 1851
+ T SD+TS E++ T HSS++ I +A + ++++ + +H +
Sbjct: 838 STQTMHFPESDTTSGRGEESTTSHSSTTHTISSAPST----TSALVEEPTSYHSSPGSTA 893
Query: 1852 ST--PGLEKDSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKI 1909
+T P SG S++ Q T P E TT G +
Sbjct: 894 TTHFPDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTAL 953
Query: 1910 ERTTKSP-----SDSGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSYDISEKTT 1964
+T +P S + +S TT +P S E TT G +T
Sbjct: 954 PGSTTTPGLSERSTTFHSSPRSPATTLSPASTTSSGVSEESTTSRSRPGSTHTTAFPDST 1013
Query: 1965 SPPEVSGYSYE------KTERSRRLLDDISNGYDDSEDGGHTLG---DPSYSYETTEKIT 2015
+ P +S +S T+ + ++G H+ D + S +T ++
Sbjct: 1014 TTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSSGSTDTALSPGSTTALS 1073
Query: 2016 SFPESEGY-SYETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPS 2074
ES + S ST TT PD ST E TR +ST S T+ A SP
Sbjct: 1074 FGQESTTFHSNPGSTHTTLFPD-STTSSGIVEASTRV-HSSTGSPRTT--LSPASSTSPG 1129
Query: 2075 EARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPP-- 2132
+ S+ HP + + P+P + P EES G P
Sbjct: 1130 LQGE-------STAFQTHP----ASTHTTPSPPS--TATAPVEESTTYHRSPGSTPTTHF 1176
Query: 2133 PGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKT 2192
P +++ S A T S T T E T+P T
Sbjct: 1177 PASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTT 1236
Query: 2193 VTYKHMDPPPAPVQDRSPSPRHPDVSM----VDPEALAIEQNLGKALKKDLKEKTKTKKP 2248
RSP+ SM V E+ G T P
Sbjct: 1237 TPGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEESTTSRSQPGST--HSTVSPASTTTP 1294
Query: 2249 GTKTKSSSPVKKSDGKSK----PLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTT 2304
G +S++ S G ++ P + + G +E + SR AS E +
Sbjct: 1295 GLSEESTTVYSSSRGSTETTVFPHSTTTSVHG-EEPTTFHSRPASTHTTLFTEDSTTSGL 1353
Query: 2305 TPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVP 2351
T E A G +T A + + + +T P ++ +T + P
Sbjct: 1354 TEESTAFPGSPASTQTGLPATLTTADLGEESTTFPSSSGSTGTKLSP 1400
Score = 80.1 bits (196), Expect = 2e-14
Identities = 291/1368 (21%), Positives = 433/1368 (31%), Gaps = 242/1368 (17%)
Query: 1047 AVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDE------------------ 1088
A+ AG +E+ F ++P SP +S + +E
Sbjct: 1677 ALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPG 1736
Query: 1089 --TLPGGSESEATASDEENRED---QPEEFTATSGYTQSTIEISS----EPTPMDEMSTP 1139
T+PG S+ + D P TA+S +ST SS E T + + +T
Sbjct: 1737 STTMPGVSQESTASHSSPGSTDTTLSPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTA 1796
Query: 1140 RDVMSDETN-NEETESPSQEFV---NITKYESSLYSQEYSKPADVTPLNGFSEGSKTDAT 1195
++ T + T SP + T+ S Q + D P T
Sbjct: 1797 SGLLEASTPVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPSSKDTMPA--------PPTT 1848
Query: 1196 DGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSK 1255
S ++ PSS FS S STTL + + V S
Sbjct: 1849 TSAFVELSTTSHGSPSSTPTTHFSAS------------STTLGRSEESTTVHS------- 1889
Query: 1256 SPSLSPSPPSPLEKTPLG--ERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASP 1313
SP + + PSP T G E S + +P + E + S E +
Sbjct: 1890 SPVATATTPSPARSTTSGLVEESTAYHSSPGSTQTMHFPESSTASGR------SEESRTS 1943
Query: 1314 EDKTLEVVSPSQSVTGSAGHTP--YYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDE 1371
T +S S T + P Y+ SP ++H P + + E
Sbjct: 1944 HSSTTHTISSPPSTTSALVEEPTSYHSSPGSTATTHFPDS------------STTSGRSE 1991
Query: 1372 NERASVSPMDEP---VPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESP 1428
AS S D V + S +L + P I S S + L G +S
Sbjct: 1992 ESTASHSSQDATGTIVLPARSTTSVLLGESTTSP-ISSGSMETTALPGSTTTPGLSEKST 2050
Query: 1429 FEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQP 1488
S + SP + TS+ + ++ S + F T + S+
Sbjct: 2051 TFHSSPR--SPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDSTTTPGLSRHSTT- 2107
Query: 1489 ALALDERKLGDVSPTQIDVSQF--GSFKEDTKMSISEGT----VSDKSATPVDEGVAEDT 1542
G T + S G +E T S G+ +S S T + G T
Sbjct: 2108 ----SHSSPGSTDTTLLPASTTTSGPSQESTTSHSSPGSTDTALSPGSTTALSFGQESTT 2163
Query: 1543 YSHMEGVASVSTASVATSSFPEPTTD----DVSPSLHAEVGSPHSTEVDDSLSVSVVQTP 1598
+ G S T+ FP+ TT + S +H+ GSP +T S + +Q
Sbjct: 2164 FHSSPG-------STHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGE 2216
Query: 1599 TTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQ-- 1656
+T +T P +P S TA HRS S+ + F S
Sbjct: 2217 STAFQTH--------PASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGH 2268
Query: 1657 SLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDND 1716
S SPD H T +G E S + +I P
Sbjct: 2269 SEKSTIFHSSPDASGTTPSSAHSTTSGRGE-----------STTSRISPGS--------- 2308
Query: 1717 LSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSL-YASLTSEKVQSLEG 1775
+E+ ++ +P S A T + +SP T A + + S TS
Sbjct: 2309 -TEITTLPGSTTTPGLSEAST-TFYSSPRSPTTTLSPASMTSLGVGEESTTSRSQPGSTH 2366
Query: 1776 EKLSPKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSSSPPIDAASAEPYGFRAS 1835
+SP S +P ES+ +YS + + + V +T P EP F +
Sbjct: 2367 STVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRT--------PTTSVRGEEPTTFHSR 2418
Query: 1836 VLFDTMQHHLALNRDLSTPGLEKDSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKT 1895
H D +T GL EE+T P T
Sbjct: 2419 ---PASTHTTLFTEDSTTSGL------------------TEESTAFPGSPASTQTGLPAT 2457
Query: 1896 TRTSDVGGYYYEKIERTTKSPSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGY 1955
T+D+G E +T PS SG + TT +P S + E T
Sbjct: 2458 LTTADLG-------EESTTFPSSSGST-----GTTLSPARSTTSGLVGEST-----PSRL 2500
Query: 1956 SYDISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKIT 2015
S +E TT P + S L + + Y TL + TT
Sbjct: 2501 SPSSTETTTLPGSPTTPS---------LSEKSTTFYTSPRSPDATLSPAT----TTSSGV 2547
Query: 2016 SFPESEGYSYETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSE 2075
S S +S ST TT PD++T TP S +S T SP
Sbjct: 2548 SEESSTSHSQPGSTHTTAFPDSTT-----------TPGLSRHS--------TTSHSSPGS 2588
Query: 2076 ARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGG 2135
D L L +S P E + S +P + S T +S PG
Sbjct: 2589 T--DTTL-LPASTTTSGPSQESTTSHSSPGSTDTALSPGSTTALSFG-QESTTFHSSPGS 2644
Query: 2136 KQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTY 2195
D T + + E++ S P T P+ + + + ES T T T+
Sbjct: 2645 THTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGL--QGESTTFQTHPASTH 2702
Query: 2196 KHMDPP---PAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKT 2252
PP APV++ + R P S A G + K + + GT
Sbjct: 2703 TTPSPPSTATAPVEESTTYHRSPG-STPTTHFPASSTTSGHSEKSTIFHSSPDAS-GTTP 2760
Query: 2253 KSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKES----VEKAAKPTTT--P 2306
S+ G+S SP G E + +P E+ PTTT P
Sbjct: 2761 SSAHSTTSGRGESTTSRISP---GSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSP 2817
Query: 2307 EVKAARGEEKDKETKNAANASASKS---AKTATAGPGTTKTTKSSAVP 2351
+ G ++ T + S + A T T G TT S+ P
Sbjct: 2818 ASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSP 2865
Score = 63.9 bits (154), Expect = 2e-09
Identities = 233/1139 (20%), Positives = 395/1139 (34%), Gaps = 199/1139 (17%)
Query: 1066 TTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEE--------FTATS 1117
+T + +G +P R SS TLPG + + + P T +S
Sbjct: 4043 STTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLSPATTTSS 4102
Query: 1118 GYTQSTIEISSEP-----TPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQ 1172
G ++ + S+P T + +T + + T + ++ ++ ++ +S Q
Sbjct: 4103 GVSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTTSHSSQGSTEATLSPGSTTASSLGQ 4162
Query: 1173 E----YSKPAD--------------------------------VTPLNGFSEGSKTDATD 1196
+ +S P D +TP + S G + ++T
Sbjct: 4163 QSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASSTSTGLQEESTT 4222
Query: 1197 GKDYNASASTI-SPPSS----MEEDKFSRSALRDAYCSEVKA-STTLDIKDSISAVSSE- 1249
+ + +S+ T SPPS+ +E S + A STTL + + V S
Sbjct: 4223 FQSWPSSSDTTPSPPSTTAVPVEVSTTYHSRPSSTPTTHFSASSTTLGRSEESTTVHSSP 4282
Query: 1250 -----KVSPSKS--------PSLSPSPPSPLEKTP---------LGERSVNFSLTPNEIK 1287
+ P++S P+ SP E T L E+S F +P
Sbjct: 4283 GATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKSTTFYSSPR--- 4339
Query: 1288 VSAEAEVAPVSPE---VTQEVVEEH--------CASPEDKTLEVVSPSQSVT-GSAGHTP 1335
S + ++P S V++E H A P T+ VS + + S G T
Sbjct: 4340 -SPDTTLSPASTTSSGVSEESTTSHSRPGSMHTTAFPSSTTMPGVSQESTASHSSPGSTD 4398
Query: 1336 YYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVL 1395
SP +S L E + P S E + D + + PV S L
Sbjct: 4399 TTLSPGSTTASSLGPESTTFHSS-PGSTETTLLPDNTTASGLLEASTPVHSSTGSPHTTL 4457
Query: 1396 SPLRSPPLIGSESAYESFLSADD--KASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSL 1453
SP S G + ++S+ ++ D A + E + GSP S++
Sbjct: 4458 SPAGSTTRQGESTTFQSWPNSKDTTPAPPTTTSAFVELSTTSHGSPSSTPTTHFSASSTT 4517
Query: 1454 YQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSF 1513
+E + +P+ T A S+ L ++E SP F
Sbjct: 4518 LGRSEESTTVHSSPV------ATATTPSPARSTTSGL-VEESTTYHSSPGSTQTMHFPE- 4569
Query: 1514 KEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASV--STASVATSSFPEPTT---- 1567
T E T S S T T + +E S S S AT+ FP+ +T
Sbjct: 4570 SNTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGR 4629
Query: 1568 DDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPK 1627
+ S + H+ + + + + SV+ +T S S E P S + P S K
Sbjct: 4630 SEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPIS-SGSMETTALPGSTTTPGLSEK 4688
Query: 1628 TAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEV 1687
+ H S S+ + F S +S + TV + + T P+
Sbjct: 4689 STTF------HSSPSSTPTTHFSASSTTLG-------RSEESTTVHSSPV-ATATTPSPA 4734
Query: 1688 DYSPSDMQDSSLSHKIPP--MEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPL 1745
+ S + + S ++ P + + + + S S+ S +T + +P S L
Sbjct: 4735 RSTTSGLVEESTAYHSSPGSTQTMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSAL 4794
Query: 1746 QEDTLSDVAPPRDMSL----YASLTSEKVQSLEGEKLSPKSD-ISPLTPR--------ES 1792
E+ S + P ++ +S TS + + SP ++ I+PL ES
Sbjct: 4795 VEEPTSYHSSPGSIATTHFPESSTTSGRSEESTASHSSPDTNGITPLPAHFTTSGRIAES 4854
Query: 1793 SPLY-SPTFSDSTSA-------VKEKTATCHSSSSPP----------IDAASAEPYGFRA 1834
+ Y SP ++T A + K+ +SSS P + S EP +
Sbjct: 4855 TTFYISPGSMETTLASTATTPGLSAKSTILYSSSRSPDQTLSPASMTSSSISGEPTSLYS 4914
Query: 1835 SVLFDTMQHHLALNRDLSTPGLEKDSGGKTPGDFSYAYQKP--EETTRSPDEEDYDYESY 1892
H A +T GL ++S + + KP ETT SP +
Sbjct: 4915 QA---ESTHTTAFPASTTTSGLSQES--------TTFHSKPGSTETTLSPGSITTSSFAQ 4963
Query: 1893 EKTTRTSDVGGYYYEKIERTTKSP---SDSGYSYETIGKTTKTPEDGDYSYEI-IEKTTR 1948
E TT S G +T P +S Y + G T T + I +++T
Sbjct: 4964 EFTTPHSQPGSALSTVSPASTTVPGLSEESTTFYSSPGSTETTAFSHSNTMSIHSQQSTP 5023
Query: 1949 TPEEGGYSYDISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDP--SY 2006
P+ G+++ + T + ++ S + S D T P S
Sbjct: 5024 FPDSPGFTHTVLPATLTTTDIG---------------QESTAFHSSSDATGTTPLPARST 5068
Query: 2007 SYETTEKITSFPESEGYSYET----STKTTRTPDTSTYCYETAEKITRTPQASTYSYET 2061
+ + + T+F S +Y T S+ T+ + ST + T+ T T ST S ET
Sbjct: 5069 ASDLVGEPTTFYISPSPTYTTLFPASSSTSGLTEEST-TFHTSPSFTST-IVSTESLET 5125
Score = 57.0 bits (136), Expect = 2e-07
Identities = 181/863 (20%), Positives = 291/863 (33%), Gaps = 157/863 (18%)
Query: 1047 AVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDE------------------ 1088
A+ AG +E+ F ++P SP +S + +E
Sbjct: 4317 ALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSMHTTAFPS 4376
Query: 1089 --TLPGGSESEATASDEENRED---QPEEFTATSGYTQSTIEISS----EPTPMDEMSTP 1139
T+PG S+ + D P TA+S +ST SS E T + + +T
Sbjct: 4377 STTMPGVSQESTASHSSPGSTDTTLSPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTA 4436
Query: 1140 RDVMSDETN-NEETESPSQEFV---NITKYESSLYSQEYSKPADVTPLNGFSEGSKTDAT 1195
++ T + T SP + T+ S Q + D TP T
Sbjct: 4437 SGLLEASTPVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPNSKDTTPA--------PPTT 4488
Query: 1196 DGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSK 1255
S ++ PSS FS S STTL + + V S
Sbjct: 4489 TSAFVELSTTSHGSPSSTPTTHFSAS------------STTLGRSEESTTVHS------- 4529
Query: 1256 SPSLSPSPPSPLEKTPLG--ERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASP 1313
SP + + PSP T G E S + +P + E S E +
Sbjct: 4530 SPVATATTPSPARSTTSGLVEESTTYHSSPGSTQTMHFPESNTTSGR------GEESTTS 4583
Query: 1314 EDKTLEVVSPSQSVTGSAGHTP--YYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDE 1371
T +S + S T + P Y+ SP ++H P + + E
Sbjct: 4584 HSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDS------------STTSGRSE 4631
Query: 1372 NERASVSPMDEP---VPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESP 1428
AS S D V + S +L + P I S S + L G
Sbjct: 4632 ESTASHSSQDATGTIVLPARSTTSVLLGESTTSP-ISSGSMETTALPGSTTTPG------ 4684
Query: 1429 FEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKST-DFAPIKEDFGQEKKTDDVEAMSSQ 1487
EKS S +P + +++S + E +T +P+ T A S+
Sbjct: 4685 LSEKSTTFHSSPSSTPTTHFSASSTTLGRSEESTTVHSSPVAT------ATTPSPARSTT 4738
Query: 1488 PALALDERKLGDVSPTQIDVSQF------GSFKEDTKMSISEGTVSDKSATPVDEGVAED 1541
L ++E SP F E+++ S S T + S + E+
Sbjct: 4739 SGL-VEESTAYHSSPGSTQTMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSALVEE 4797
Query: 1542 TYSHMEGVASVSTASVATSSFPEPTT----DDVSPSLHAEVGSPHSTEVDDSLSVSV-VQ 1596
S+ S S+AT+ FPE +T + S + H+ + T + + S +
Sbjct: 4798 PTSYHS-----SPGSIATTHFPESSTTSGRSEESTASHSSPDTNGITPLPAHFTTSGRIA 4852
Query: 1597 TPTTFQETEMSPSKEECPRPMSISPPDFSPKT----AKSRTPVQDHRSEQSSMSIEFGQE 1652
TTF +SP E + + P S K+ + SR+P Q + S G+
Sbjct: 4853 ESTTFY---ISPGSMETTLASTATTPGLSAKSTILYSSSRSPDQTLSPASMTSSSISGEP 4909
Query: 1653 SPEQSLAMDFSRQSPDHPTVGAGVLHITEN-----GPTEVDYSPSDMQDSSLSHKIPPME 1707
+ S A + T +G+ + G TE SP + SS + +
Sbjct: 4910 TSLYSQAESTHTTAFPASTTTSGLSQESTTFHSKPGSTETTLSPGSITTSSFAQEFTTPH 4969
Query: 1708 E----------PSYTQDNDLSELISV--SQVEASPSTSSAHTPSQIASPLQEDTLSDVAP 1755
P+ T LSE + S ++ +T+ +H+ + Q D
Sbjct: 4970 SQPGSALSTVSPASTTVPGLSEESTTFYSSPGSTETTAFSHSNTMSIHSQQSTPFPDSPG 5029
Query: 1756 PRDMSLYASLTSEKV--QSLEGEKLSPKSDISPLTPRES---------------SPLYSP 1798
L A+LT+ + +S S + +PL R + SP Y+
Sbjct: 5030 FTHTVLPATLTTTDIGQESTAFHSSSDATGTTPLPARSTASDLVGEPTTFYISPSPTYTT 5089
Query: 1799 TF--SDSTSAVKEKTATCHSSSS 1819
F S STS + E++ T H+S S
Sbjct: 5090 LFPASSSTSGLTEESTTFHTSPS 5112
Score = 50.1 bits (118), Expect = 3e-05
Identities = 131/633 (20%), Positives = 201/633 (31%), Gaps = 95/633 (15%)
Query: 1056 GGAEEQYGFLTTPTKQLGAQSPGREPASSIHDE--TLPGGSESEATASDEENREDQPEEF 1113
G +EE ++P SP R S + +E T S T E+
Sbjct: 4519 GRSEESTTVHSSPVATATTPSPARSTTSGLVEESTTYHSSPGSTQTMHFPESNTTSGRGE 4578
Query: 1114 TATSGYTQSTIEISSEPTPMDEM-STPRDVMSDETNNEETESPSQEFVNITKYESSL-YS 1171
+T+ ++ +T ISS P+ + P S + T P + ES+ +S
Sbjct: 4579 ESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHS 4638
Query: 1172 QEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEV 1231
+ + V P + ++T + S T + P S S +
Sbjct: 4639 SQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTFHSSPSS 4698
Query: 1232 KASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLG--ERSVNFSLTPNEIKVS 1289
+T + S E + SP + + PSP T G E S + +P +
Sbjct: 4699 TPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTAYHSSPGSTQTM 4758
Query: 1290 AEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTP--YYQSPTDEKSSH 1347
E + S E + T +S S T + P Y+ SP ++H
Sbjct: 4759 HFPESSTASGR------SEESRTSHSSTTHTISSPPSTTSALVEEPTSYHSSPGSIATTH 4812
Query: 1348 LPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDE----PVPDSESPIEKVLSPLRSPPL 1403
P + + E AS S D P+P + ++ S
Sbjct: 4813 FPES------------STTSGRSEESTASHSSPDTNGITPLPAHFTTSGRIAE---STTF 4857
Query: 1404 IGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTS-------TSLYQD 1456
S + E+ L++ G A+S S + SPDQ + MTS TSLY
Sbjct: 4858 YISPGSMETTLASTATTPGLSAKSTILYSSSR--SPDQTLSPASMTSSSISGEPTSLYSQ 4915
Query: 1457 KQEGKSTDFAPIKEDFG--QEKKTDDVEAMSSQPALALDE------------------RK 1496
+ +T F G QE T + S++ L+
Sbjct: 4916 AESTHTTAFPASTTTSGLSQESTTFHSKPGSTETTLSPGSITTSSFAQEFTTPHSQPGSA 4975
Query: 1497 LGDVSPTQIDV----------------SQFGSFKEDTKMSI----------SEG---TVS 1527
L VSP V ++ +F MSI S G TV
Sbjct: 4976 LSTVSPASTTVPGLSEESTTFYSSPGSTETTAFSHSNTMSIHSQQSTPFPDSPGFTHTVL 5035
Query: 1528 DKSATPVD---EGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHST 1584
+ T D E A + S G + S A+ EPTT +SPS P S+
Sbjct: 5036 PATLTTTDIGQESTAFHSSSDATGTTPLPARSTASDLVGEPTTFYISPSPTYTTLFPASS 5095
Query: 1585 EVDDSLSVSVV-QTPTTFQETEMSPSKEECPRP 1616
S T +F T +S E P
Sbjct: 5096 STSGLTEESTTFHTSPSFTSTIVSTESLETLAP 5128
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 89.7 bits (221), Expect = 3e-17
Identities = 127/596 (21%), Positives = 261/596 (43%), Gaps = 74/596 (12%)
Query: 502 LEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKES 561
+E+ K L ++ LA Q++ + T + ++ +L +E L + +P + R
Sbjct: 1743 VEEKKKLAEEEEALAWQREKLSEEETKLAQEEELL--IQEKEKLAQHKEKMPEEEERLGR 1800
Query: 562 KEETPEVTKVNHVEKPPK------VESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSP 615
K E K+ +K + +K K+++ + K + E K EKE ++ + +
Sbjct: 1801 KREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENL 1860
Query: 616 V----KAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDK----- 666
+ + ++KQ VK K + + + K +KE K K+++A+ E K
Sbjct: 1861 LYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVE 1920
Query: 667 -TPIKKEEKPKKEEVKKEVKKEIKKEEKK-EPKKEVKKETPPKEVK-KEVKKEEKKEVKK 723
+ KK+EK +E++K ++K + + +K+ + ++ KE ++ K + +E+ + V+
Sbjct: 1921 DSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEG 1980
Query: 724 EEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESV---KKDSVAAGKPK-EK 779
+E K E + + K + ++ +L+ K+ E+ + ++ +A GK + +
Sbjct: 1981 KETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTR 2040
Query: 780 GKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKD 839
G+ ++ + K A+A + + + KE ++ + + LT+D
Sbjct: 2041 GQRIFVQGQRKLAKASRKLIKKRESLS--------------KEPAKLNKILKALQKLTRD 2086
Query: 840 FEELKAEEVDVTK-------------------DIKP------QLELIEDEEKLKETEPVE 874
+L EE+ +TK DIK + EL +DE+KL +
Sbjct: 2087 ERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKL 2146
Query: 875 AY----VIQKEREVTKGP---AESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFE 927
A +I KE ++T+ A E I E EG E+ EE+ P K+ ++ +
Sbjct: 2147 ANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEE--EEVIPFLKRRWRKRKEAK 2204
Query: 928 DEGAGFEESSETGDYEEKAE--TEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAY 985
E+ S D E E +EE E ++ E+ +S+ + E+EE + E
Sbjct: 2205 RGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVRE 2264
Query: 986 IREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEA 1041
E+R+ G+++ E +E +K + E+ +EE E+++ + +EE E+ E+
Sbjct: 2265 EEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETES 2320
Score = 84.7 bits (208), Expect = 1e-15
Identities = 132/595 (22%), Positives = 246/595 (41%), Gaps = 41/595 (6%)
Query: 497 NILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKS 556
N +E L K K + + K+ LA +K Q ++ KL QR ++ L + SK
Sbjct: 1821 NSMEELTKNKMILYQKKNLAQEKKNLAQ------EKEKLAQRKENL--LYNKERLTHSKK 1872
Query: 557 VRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEP-SP 615
+ K + K+ + + KE V+ KK+K +TE K E + K+E +
Sbjct: 1873 QLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQ 1932
Query: 616 VKAEVA-EKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKED----KTPIK 670
K ++A EK K + E + KE K + K E+ + V KE +TP
Sbjct: 1933 EKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPET 1992
Query: 671 KEEKPKKEEVKKEVKKEIKKEEK---KEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKE 727
++ + ++ ++++ EEK E + +E+ + K E + ++ V+ + K
Sbjct: 1993 SRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKL 2052
Query: 728 PKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKK 787
K K + K S P K AL+ K+ + E + ++ + K K +K +
Sbjct: 2053 AKASRKLIKKRESLSKEPAKLNKILKALQ-KLTRDERKLTQEEIKMTKMKRALFVKERRL 2111
Query: 788 EGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEE 847
+ ++ + + A K R +++ E +T++ +L +
Sbjct: 2112 SIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKH 2171
Query: 848 VDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKG--PAESPDEGITTTEGEG-- 903
+V D + + IE+EE + P +K +E +G P E + E E
Sbjct: 2172 SEVILDDEEEGG-IEEEEVI----PFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHF 2226
Query: 904 --ECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEH 961
E E +ELE E ++ E+ E+E EE E EE+ E +E EE EE E
Sbjct: 2227 SEEMESLLDELEKQESLSSEEEEEREEE----EEREEEEVREEEEERKEEEEGEEKQVEK 2282
Query: 962 VCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEAD 1021
K + +E + + + + E++E + S ++ E + + E+ E+ EEE D
Sbjct: 2283 EEEEKKKKKKEKKKEEVQEKEEVF--EEKEEIMSEEE--TESLSDEEEEEESCSLEEEVD 2338
Query: 1022 EE----DKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQL 1072
E K + + +E + + + V++++ G + G L +P K+L
Sbjct: 2339 REKEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKL 2393
Score = 78.2 bits (191), Expect = 9e-14
Identities = 152/650 (23%), Positives = 260/650 (40%), Gaps = 120/650 (18%)
Query: 543 ESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPI--KTETKP 600
E L L + + +EE + E+ K+ +E++++++ + + E P
Sbjct: 1733 EELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMP 1792
Query: 601 SVTEKEVPSKEEPSPVKAEVAEKQATDVK--PKAAKEKTVKKETKVKPEDKK---EEKEK 655
E+ +E+ K ++A+K+ + + K K + + K ++KK +EKEK
Sbjct: 1793 EEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEK 1852
Query: 656 --PKKE--VAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKE--VKKETPPKEV 709
+KE + KE T KK+ K ++ K + EEK +KE +KK+ E
Sbjct: 1853 LAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAET 1912
Query: 710 KKEVKKEEKKEVKKEEKEPKKEI-----KKLPKDAKKSSTPLSEAKKPAALKPKVPK-KE 763
+K++ + E KK+EK ++++ K + + K+ L AK+ AL ++ + E
Sbjct: 1913 EKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAE 1972
Query: 764 ESVK----KDSVAAGKPKEKGK-------------------IKVIKKEGKAAEAVAAAVG 800
E ++ K++++ G+ E + K++ E + + +
Sbjct: 1973 EKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIA 2032
Query: 801 TGA---TTAAVMAAAGIAAIGPA--KELEAERSLMSSP----------EDLTKDFEELKA 845
G T + G + A K ++ SL P + LT+D +L
Sbjct: 2033 KGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQ 2092
Query: 846 EEVDVTK-------------------DIK------PQLELIEDEEKLKETEPVEA----Y 876
EE+ +TK DIK + EL +DE+KL + A
Sbjct: 2093 EEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRR 2152
Query: 877 VIQKEREVTKGP---AESPDEGITTTEGEGECEQTPEELEPV----------EKQGVDDI 923
+I KE ++T+ A E I E EG E+ EE+ P K+G
Sbjct: 2153 MINKEEKMTEEESKLARKHSEVILDDEEEGGIEE--EEVIPFLKRRWRKRKEAKRGDKPK 2210
Query: 924 EKF-------EDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEE 976
EKF E E EE D EK E+ +EE EE EE + E+EE
Sbjct: 2211 EKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEE---EREEEEVREEEE 2267
Query: 977 SAKAEADAYIRE-KRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYE 1035
K E + ++ ++E + E+ +E EK E + +EE E++ E +EE E
Sbjct: 2268 ERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEE 2327
Query: 1036 PEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSI 1085
E E+ VD+ E E+Q+ K L GRE SI
Sbjct: 2328 EESCSLEE----EVDREKEILKKEKQFKLQEQRRKSL----RGRERVLSI 2369
Score = 72.4 bits (176), Expect = 5e-12
Identities = 81/364 (22%), Positives = 178/364 (48%), Gaps = 22/364 (6%)
Query: 530 VKQTKLKQRA---DSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKV 586
+K TK+K+ + R S++ + + ++ E T + K+ K K+ +K +
Sbjct: 2095 IKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKL--ARKQRKLANKMRR 2152
Query: 587 MV-KKDKPIKTETKPSVTEKEVP---------SKEEPSPVKAEVAEKQATDVKPKAAKEK 636
M+ K++K + E+K + EV +EE P K+ + KEK
Sbjct: 2153 MINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEK 2212
Query: 637 TVKKETKVKPEDK-KEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKE 695
+ +V+ E+ EE E E+ K+E + ++EE+ ++EE ++E +E ++E K+E
Sbjct: 2213 FSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEE 2272
Query: 696 PKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKK-LPKDAKKSSTPLSEAKKPAA 754
+ E K+ +E KK+ KKE+KKE +E++E +E ++ + ++ +S + E ++ +
Sbjct: 2273 EEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCS 2332
Query: 755 LKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGI 814
L+ +V +++E +KK+ + + + ++ ++ V G A V+ +
Sbjct: 2333 LEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGR-AIRLGVLKSPLK 2391
Query: 815 AAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVE 874
+ A E++ E++ + PE +E+ KA V++ + ++ ++ E + + EP+
Sbjct: 2392 KLMSTALEMK-EKTPVPVPEKQI-SWEDKKATVVEIPRKFLGTMD--KEREVMGKYEPIP 2447
Query: 875 AYVI 878
+V+
Sbjct: 2448 PHVL 2451
Score = 68.2 bits (165), Expect = 1e-10
Identities = 118/506 (23%), Positives = 216/506 (42%), Gaps = 63/506 (12%)
Query: 554 SKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEP 613
SK K++ +++P+ + V+K KV ++ M K+++ + E + T +E K+E
Sbjct: 1388 SKKEEKKTFQKSPKQGR-KAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEG 1446
Query: 614 SPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEE 673
V E D K + K V ET+ + KEE EK + ++E+K E+
Sbjct: 1447 KLVMIERTPSWQ-DWKKAWDEWKQVHGETRKSWKAWKEEWEK---RLLQEEEKLHQAGEK 1502
Query: 674 KPKKEEVKKEVKKEIKKEEKKE---------PKKEVKKETPPKEVKKEVKKEEKKEVKKE 724
+EE+ +E KK +K EE K+ K++ K+ +++EV + E +E +++
Sbjct: 1503 LSPEEEMLQEDKK-LKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSR-EGEEKEQQ 1560
Query: 725 EKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKV 784
E ++ I++ K A+ KK A + K+ ++EE + ++ + + K
Sbjct: 1561 VTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAY 1620
Query: 785 IKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELK 844
+K E +A A G A +A G A++L +R + L K +E++
Sbjct: 1621 VKITQDDRE-MAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKR------KKLAKKWEKVA 1673
Query: 845 AEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGE 904
EE +L + KL E + + A ++ E P E E
Sbjct: 1674 REEE----------KLAKKGGKLAEVKNILAQKVE----------ELPQREQNLDWQEKE 1713
Query: 905 CEQTPEELE-PVEKQGVDDIEKFEDEGAGFEESSETGDYEE----------KAETEEAEE 953
Q EELE +E+ + E ++EG EE + + EE + ET+ A+E
Sbjct: 1714 LAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQE 1773
Query: 954 PEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAI----- 1008
E +E ++ K E+EE + + I EK+ +A +R M+E
Sbjct: 1774 EELLIQEKEKLAQHKEKMPEEEERLGRKREQLI-EKKMKLAQKRERWINSMEELTKNKMI 1832
Query: 1009 ---EKGEAEQSEEEADEEDKAEDARE 1031
+K A++ + A E++K +E
Sbjct: 1833 LYQKKNLAQEKKNLAQEKEKLAQRKE 1858
Score = 65.5 bits (158), Expect = 6e-10
Identities = 114/509 (22%), Positives = 209/509 (41%), Gaps = 63/509 (12%)
Query: 580 VESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVK 639
V ++K + ++ I+ + VT+ EV +E P + E A+K+A D+ + +K
Sbjct: 1310 VPPEKKPIFIQEGAIREDMIQGVTQ-EVIRHKEVMPREEEQAQKKARDMLGLEETQVILK 1368
Query: 640 KETKV---KPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEP 696
K KV +P + KE KKE K K+P + + +KE ++K+E+ KEE+
Sbjct: 1369 KGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMS 1428
Query: 697 KKEVKKETPPKEVKKEVKK----------EEKKEVKKEEKEPKKEIKKLPKDAKK--SST 744
++ + T ++V K+ K ++ K+ E K+ E +K K K+
Sbjct: 1429 EEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKR 1488
Query: 745 PLSEAKKPAALKPKVPKKEESVKKD-------------SVAAGKPKE---KGKIKVIKKE 788
L E +K K+ +EE +++D ++ + K KE K + +V +E
Sbjct: 1489 LLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEE 1548
Query: 789 GKAAEAVAAAVGTGATTAAVMAAAGIAAI------GPAKELEAERSLMSSPEDLTKDFEE 842
+ E + A I K + ER L E L ++ +
Sbjct: 1549 EVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQ 1608
Query: 843 LKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGE 902
L EE K + +++ +D+ ++ + E A QKE + + + E +
Sbjct: 1609 LAQEE---RKLAQAYVKITQDDREMAQAEGKFA---QKEETLAQRGEKLSQEAEKLAQKR 1662
Query: 903 GEC----EQTPEELEPVEKQG-----VDDI--EKFEDEGAGFEESSETGDYEEKAETEEA 951
+ E+ E E + K+G V +I +K E+ + + D++EK +E
Sbjct: 1663 KKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEE----LPQREQNLDWQEKELAQEL 1718
Query: 952 EEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKG 1011
EE E D EE + K EE E + E+ E++A ++ E+ + ++
Sbjct: 1719 EELEWDMEE----LSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEE 1774
Query: 1012 EAEQSEEEADEEDKAEDAREEEYEPEKME 1040
E E+E + K + EEE K E
Sbjct: 1775 ELLIQEKEKLAQHKEKMPEEEERLGRKRE 1803
Score = 63.9 bits (154), Expect = 2e-09
Identities = 70/267 (26%), Positives = 126/267 (47%), Gaps = 23/267 (8%)
Query: 483 KIIRVLFPGNSTQYNILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSR 542
K+ R LF + +I + +K DF ++ + +LT KQ KL +
Sbjct: 2099 KMKRALFV-KERRLSIEQSKLDIKEWDFSEK----RSELTKDEKKLARKQRKLANKMRRM 2153
Query: 543 ESLKPAAKPLPSKSVRKESK-----EETPEVTKVNHVEKPPKVESKEKVMVKKDKPI-KT 596
+ + SK RK S+ EE + + + + K K + DKP K
Sbjct: 2154 INKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKF 2213
Query: 597 ETKPSVTEKEVPSKEEPSPVKAEVAEKQAT---DVKPKAAKEKTVKKETKVKPEDKKEEK 653
++ E E EE + E+ ++++ + + + +E+ ++E + + E++KEE+
Sbjct: 2214 SSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEE 2273
Query: 654 EKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEV 713
E +K+V K+E++ KK+EK KKEEV++ KEE E K+E+ E + + E
Sbjct: 2274 EGEEKQVEKEEEEKKKKKKEK-KKEEVQE-------KEEVFEEKEEIMSEEETESLSDEE 2325
Query: 714 KKEEKKEVKKEEKEPKKEIKKLPKDAK 740
++EE + +EE + +KEI K K K
Sbjct: 2326 EEEESCSL-EEEVDREKEILKKEKQFK 2351
Score = 62.4 bits (150), Expect = 5e-09
Identities = 99/418 (23%), Positives = 180/418 (43%), Gaps = 63/418 (15%)
Query: 638 VKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEE----VKKEV--KKEIKKE 691
+KKE+KV ED + P+K+ PI +E +E+ V +EV KE+
Sbjct: 1294 LKKESKVLLEDLDWDVVPPEKK--------PIFIQEGAIREDMIQGVTQEVIRHKEVMPR 1345
Query: 692 EKKEPKKEVKKETPPKEVKKEVKKEEK------------KEVKKEEKEPKKEIKKLPKDA 739
E+++ +K+ + +E + +KK +K KE+ K KE KK +K PK
Sbjct: 1346 EEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISK--KEEKKTFQKSPKQG 1403
Query: 740 KKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAA---EAVA 796
+K+ + + +K +K ++ K+E + ++ +E KV+K+EGK +
Sbjct: 1404 RKA---VQKERKVGKIKREMTKEERDMSEEVEEMATLEE----KVVKQEGKLVMIERTPS 1456
Query: 797 AAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKP 856
A A + E E+ L+ E L + E+L EE
Sbjct: 1457 WQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEE--------- 1507
Query: 857 QLELIEDEEKLKETEPVEAY---VIQKEREVT-KGPAESPDEGITTTEGEGECEQTPEE- 911
E++++++KLK E + + + K +E K E E + EGE + +Q EE
Sbjct: 1508 --EMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQ 1565
Query: 912 --LEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKH 969
++ K ++ E +E + EEK EE + + EE A
Sbjct: 1566 RHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQ---EERKLAQAYVK 1622
Query: 970 SPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGE--AEQSEEEADEEDK 1025
+D E A+AE +K E++A ++ ++ ++ +K + A++ E+ A EE+K
Sbjct: 1623 ITQDDREMAQAEGK--FAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEK 1678
Score = 59.7 bits (143), Expect = 3e-08
Identities = 147/724 (20%), Positives = 283/724 (39%), Gaps = 132/724 (18%)
Query: 555 KSVRKESKEETPEVTKVN-HVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEP 613
+ V +E +E+ +VT+ H+++ K + + +K E + E+E ++EE
Sbjct: 1548 EEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEER 1607
Query: 614 SPVKAEVAEKQA------TDVKPKAAKEKTVKKETKVKPEDKKEEKEKPK-----KEVAK 662
+ E QA D + A+ K +KE + +K +E K K++AK
Sbjct: 1608 QLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAK 1667
Query: 663 KEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKK------- 715
K +K ++E+ KK EVK + ++ ++ P++E + KE+ +E+++
Sbjct: 1668 KWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEE 1727
Query: 716 ----------------EEKKEVKKEEKEPKKEIKKLPKD----AKKSSTPLSEAKKPAAL 755
EEKK++ +EE+ + +KL ++ A++ + E +K A
Sbjct: 1728 LSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQH 1787
Query: 756 KPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIA 815
K K+P++EE + G+ +E+ K +K K + + + +A
Sbjct: 1788 KEKMPEEEERL-------GRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLA 1840
Query: 816 A----IGPAKELEAER--SLMSSPEDLTKDFEEL--KAEEVDVTKDIKPQLE-------- 859
+ KE A+R +L+ + E LT ++L ++ + I Q+E
Sbjct: 1841 QEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKE 1900
Query: 860 -LIEDEEKLKETE----PVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPE-ELE 913
+I+ +EKL ETE VE + +K+ ++ + E + +G+ E ++
Sbjct: 1901 TVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQ---EKMKLALEKAMVQGKKRLRGELDIA 1957
Query: 914 PVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAET----------EEAEEPEEDGEEHVC 963
EK ++++ +E E ET E ET +E E + EE +
Sbjct: 1958 KEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKIL 2017
Query: 964 VSASKHSPTEDEESAK-------------------AEADAYIREKRESVA---------- 994
+ + E+ E AK A+A + +KRES++
Sbjct: 2018 LHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKIL 2077
Query: 995 ------SGDDR--AEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVM 1046
+ D+R +E++ K E E D +E ++ ++ E
Sbjct: 2078 KALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEK 2137
Query: 1047 AVVDKAAEAGGAEEQYGFLTTPTKQLGAQSP-GREPASSIHDETLPGGSESEAT------ 1099
+ K + A + + K +S R+ + I D+ GG E E
Sbjct: 2138 KLARKQRKL--ANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKR 2195
Query: 1100 ---ASDEENREDQP-EEFTATSGYTQSTIEISSE-PTPMDEMSTPRDVMSDETNNEETES 1154
E R D+P E+F++ +S S E + +DE+ + S+E E E
Sbjct: 2196 RWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEE 2255
Query: 1155 PSQE 1158
+E
Sbjct: 2256 EREE 2259
Score = 42.4 bits (98), Expect = 0.006
Identities = 44/199 (22%), Positives = 90/199 (45%), Gaps = 13/199 (6%)
Query: 530 VKQTKLKQRADSRESL-----KPAAKPLPSKSVRKESKEETPEVTKVNHVE-KPPKVESK 583
+ T+++QR + +L KPA S +S + P V++ + V KP K + +
Sbjct: 1025 ILSTQVEQRLNENLTLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRR 1084
Query: 584 EKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETK 643
+ VKK E++ ++ S + ++ T+ P +E +V +
Sbjct: 1085 GQAGVKKHSQKWLRGLKKTKERD---SKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWS 1141
Query: 644 VKPEDKKEEKE--KPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPK--KE 699
K K+ +K+++K +K+ +K + + KK +++KK+ KK+ K K
Sbjct: 1142 SSTSVIKLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKV 1201
Query: 700 VKKETPPKEVKKEVKKEEK 718
+ +ET P +++ V K+ K
Sbjct: 1202 INEETTPPVMEQPVTKKVK 1220
Score = 40.8 bits (94), Expect = 0.017
Identities = 40/179 (22%), Positives = 83/179 (46%), Gaps = 17/179 (9%)
Query: 597 ETKPSVT-EKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKT---VKKETKVKPEDKKEE 652
+ KP+ + + +PS+ + S V+E+ +KP + + VKK ++ K+
Sbjct: 1044 DEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLRGLKKT 1103
Query: 653 KEKPKKEVAKK----EDKT-----PIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKE 703
KE+ K+++ + ED++ PI+ EE + ++ +K++ K+
Sbjct: 1104 KERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDISKD 1163
Query: 704 TPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKK 762
+K+ K +K++ K ++ KK+ KK K+AK ++E P ++ V KK
Sbjct: 1164 HIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAK----VINEETTPPVMEQPVTKK 1218
>gi|238624188 diffuse panbronchiolitis critical region 1 protein [Homo
sapiens]
Length = 1393
Score = 89.0 bits (219), Expect = 5e-17
Identities = 234/1108 (21%), Positives = 415/1108 (37%), Gaps = 146/1108 (13%)
Query: 1066 TTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQ------PEEFTATSGY 1119
+T T++ E + S D+T ++ + + N + + PE+ TA S
Sbjct: 176 STVTRKSDKTGRPLEKSMSTLDKTSTSSHKTTTSFHNSGNSQTKQKSTSFPEKITAASKT 235
Query: 1120 TQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD 1179
T T E ++ T V SD+ + T++ QE ++ + SL ++P +
Sbjct: 236 TYKTTGTPEESEKTEDSRTT--VASDKLLTKTTKN-IQETISANELTQSL-----AEPTE 287
Query: 1180 V--TPLNGFSEGSKTDATDGKDYNASAST-ISPPSSMEEDKFSRSALRDAYCSEVKASTT 1236
N + S + T+ ++ A+ +T +SP +E + + + + + +
Sbjct: 288 HGGRTANENNTPSPAEPTENRERTANENTTLSPAEPIENRERTANENTAPFPAGPTENRE 347
Query: 1237 LDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP 1296
+ ++ + +E + + + PSP E T GER+ N + TP+ + + E P
Sbjct: 348 MTANENTTLFPAEPTEHGERTANENTTPSPAEPTEHGERTANENTTPSPAEPTEHGERTP 407
Query: 1297 VSPEVTQEVVEEHCASPEDKTL--EVVSPSQSV-------TGSAGHTPYYQSPTDEKSSH 1347
+ + T E E L E +PS + T + TP PT+ +
Sbjct: 408 FANDKTTSSSAESTEHGERTPLANENTTPSPAEPTENRERTANENTTPSPAGPTENRE-- 465
Query: 1348 LPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPI--EKVLSPLRSPPLIG 1405
T EK PV + NE+ + SP + +P EK S P G
Sbjct: 466 --TTANEKTTLSPVEPTENRETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTEHG 523
Query: 1406 SES--AYESFLSADDKASGRGAESPFEEKSGKQGSP----DQVSPVSEMTSTSLYQDKQE 1459
+ A E+ + + + + E+ + P D+ +E T+ SL + +
Sbjct: 524 ERTPLANENTTPSPAEPTENRERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTEN 583
Query: 1460 GKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKM 1519
G+ T FA K + T+ E + LA + PT+ ++ + E+T
Sbjct: 584 GQRTPFANEKTTSSSAEPTEHEE----RTPLANENTTPSPAEPTE---NRERTANENTTP 636
Query: 1520 SISEGTVSDKSATPVDEGV---AEDTYSHMEGVASVSTASVATSSFPEPTTDDV-SPSLH 1575
S + G ++ T ++ AE T + E A+ T TSS EPT + +P +
Sbjct: 637 SPA-GPTENREMTANEKTTLFPAEPT-ENRERTANEKT----TSSPAEPTENGQRTPFAN 690
Query: 1576 AEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKE----ECPRPMSISPPDFSPKTAKS 1631
+ S + + + TT E + ++E E P P + +TA
Sbjct: 691 EKTTSSSAEPTEHGERTPLANENTTLSPAEPTENRERTANEKTTPFPAEPTENRERTANE 750
Query: 1632 RTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSP 1691
T + + E G +P LA + + S PT T P
Sbjct: 751 NT------TPSPAQPTENGDRTP---LANEKTTPSLAEPTENGKRTPFANEKTTSSSAEP 801
Query: 1692 SDMQDSS-LSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTL 1750
++ + + L+++ T++ + + +Q A P+ + T ++ +P +
Sbjct: 802 TEHAERTPLANENTTSSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTPFPAEPT 861
Query: 1751 SDVAPPRDMSLYASLTSEKVQSLEGEKLSP----KSDISPLTPRESSPLYSPTFSDSTSA 1806
+ R+ + + T + E E+++P K+ +SP P E+ T +T +
Sbjct: 862 EN----REWTANENTTLSPAEPTEHEEMTPLANEKTTLSPAEPTENGERTPFTNEKTTPS 917
Query: 1807 VKEKTATCHSSSSPPIDAAS----AEP--YGFRA-------SVLFDTMQHHLALNRDLST 1853
E T H +P + + AEP +G R S T +N D +
Sbjct: 918 SAEPTE--HGERTPLANEITTPSRAEPTEHGERIANEKATPSPAKPTEHGETTVNEDTTP 975
Query: 1854 PGLEK-DSGGKTPGDFSYAYQKPEETTRSPDE--EDYDYESYEKTTRTSDVGGYYYEKI- 1909
E ++G +TP E TT SP E E + + EKTT + + E+
Sbjct: 976 SSAEPTENGERTP-------LANENTTTSPTESTEHGERTANEKTTPSPAEPTEHGERTP 1028
Query: 1910 ---ERTTKSPSDSGYSYE--------TIGKTTKTPEDGDYSYEIIEKTTRTPE----EGG 1954
E+T SP+ E T K E G+ + EK T +PE G
Sbjct: 1029 SANEKTIPSPAKPTEHEEMTPSANENTTPSPVKPTEHGEKTTLANEKITLSPEGPTEHGA 1088
Query: 1955 YSYDISEK--------------TTSPPE-VSGYSYEKTERSRRLLDDISNGYDDSEDGGH 1999
+ +EK TTSP + ++ + E TE R +E H
Sbjct: 1089 KTTSANEKITPSLAKPTEHGERTTSPNDKITSSAAESTEHRDRATSANVITPAPAEPIKH 1148
Query: 2000 ----TLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYE----TAEKITRT 2051
TL + + TEK T PE + T+ KTTRTP+ T E T K T
Sbjct: 1149 AKRTTLAHEKMT-QVTEKSTEHPEK---TTSTTEKTTRTPEKPTLYSEKTICTKGKNTPV 1204
Query: 2052 PQASTYSYETSDLCYTAEKKSPSEARQD 2079
P+ T + + L T K+P ++ ++
Sbjct: 1205 PEKPTENLGNTTLT-TETIKAPVKSTEN 1231
Score = 86.3 bits (212), Expect = 3e-16
Identities = 275/1302 (21%), Positives = 464/1302 (35%), Gaps = 189/1302 (14%)
Query: 1128 SEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFS 1187
S+PT ++ T+N E S+E + + + +Q PAD T + S
Sbjct: 93 SKPTDKPTGNSKTIDHKSSTDNHEAPPTSEENSSNQGKDPMIRNQRSVDPADSTTTHKES 152
Query: 1188 EGSK--TDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISA 1245
G K T A K ++T + + DK R K+ +TLD ++
Sbjct: 153 AGKKHITPAPKSKINCRKSTTGKSTVTRKSDKTGRPL--------EKSMSTLD----KTS 200
Query: 1246 VSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPV-SPEVTQE 1304
SS K + S S + ++S +F P +I +++ +PE +++
Sbjct: 201 TSSHKTTTSFHNS---------GNSQTKQKSTSF---PEKITAASKTTYKTTGTPEESEK 248
Query: 1305 VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE 1364
+ DK L + + T SA + E E PA P
Sbjct: 249 TEDSRTTVASDKLLTKTTKNIQETISANELTQSLAEPTEHGGRTANENNTPSPAEPTE-- 306
Query: 1365 FSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSE-SAYESFLSADDKASGR 1423
+ + NE ++SP EP+ + E + +P + P E +A E+ + +
Sbjct: 307 -NRERTANENTTLSPA-EPIENRERTANENTAPFPAGPTENREMTANENTTLFPAEPTEH 364
Query: 1424 GAESPFEEKSGKQGSPDQ--VSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDV 1481
G + E + P + +E T+ S + + G+ T FA K + T+
Sbjct: 365 GERTANENTTPSPAEPTEHGERTANENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHG 424
Query: 1482 EAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED 1541
E + LA + PT E+ + + +E T + A P + E
Sbjct: 425 E----RTPLANENTTPSPAEPT-----------ENRERTANENT-TPSPAGPTEN--RET 466
Query: 1542 TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVG--SPHSTEVDDSLSVSVVQ--- 1596
T + ++ V ++ E TT SP+ E G +P + E S S +
Sbjct: 467 TANEKTTLSPVEPTENRETTANEKTTP--SPAEPTENGQRTPFANEKTTSSSAEPTEHGE 524
Query: 1597 -TPTTFQETEMSPSK----EECPRPMSISPPDFSPKTAKSRTPVQDHRSEQS-SMSIEFG 1650
TP + T SP++ E +P P RTP+ + ++ S + E G
Sbjct: 525 RTPLANENTTPSPAEPTENRERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENG 584
Query: 1651 QESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEE-P 1709
Q +P A + + S PT + T P++ ++ + + P P
Sbjct: 585 QRTP---FANEKTTSSSAEPTEHEERTPLANENTTPSPAEPTENRERTANENTTPSPAGP 641
Query: 1710 SYTQD---NDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLT 1766
+ ++ N+ + L E T++ T S A P + + A + S A T
Sbjct: 642 TENREMTANEKTTLFPAEPTENRERTANEKTTSSPAEPTENGQRTPFANEKTTSSSAEPT 701
Query: 1767 SEKVQSLEGEKLSPKSDISPLTPRESSPLYSPTFSDSTSAV-------KEKTATCHSSSS 1819
GE+ ++ + L+P E + T ++ T+ +E+TA +++ S
Sbjct: 702 E------HGERTPLANENTTLSPAEPTENRERTANEKTTPFPAEPTENRERTANENTTPS 755
Query: 1820 PPIDAASAEPYGFRASVLFDTMQHHLA--LNRDLSTPGLEKDSGGKTPGDFSYAYQKP-- 1875
P A G R + + LA TP + + + +A + P
Sbjct: 756 P----AQPTENGDRTPLANEKTTPSLAEPTENGKRTPFANEKTTSSSAEPTEHAERTPLA 811
Query: 1876 -EETTRSPDE--EDYDYESYEKTTR-----TSDVGGYYYEKI----------------ER 1911
E TT SP E E+ + + EKTT+ T + EK E
Sbjct: 812 NENTTSSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTPFPAEPTENREWTANEN 871
Query: 1912 TTKSPSDSGYSYETI----GKTTKTP----EDGDYSYEIIEKTTRT---PEEGGYSYDIS 1960
TT SP++ E KTT +P E+G+ + EKTT + P E G ++
Sbjct: 872 TTLSPAEPTEHEEMTPLANEKTTLSPAEPTENGERTPFTNEKTTPSSAEPTEHGERTPLA 931
Query: 1961 EKTTSPPEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPES 2020
+ T+P E TE R+ ++ + ++ H G+ + + +TT E+
Sbjct: 932 NEITTPSRA-----EPTEHGERIANEKATP-SPAKPTEH--GETTVNEDTTPSSAEPTEN 983
Query: 2021 EGYSYETSTKTTRTPDTSTYCYETA--EKITRTPQASTYSYETSDLCYTAEKKSPSEARQ 2078
+ + TT +P ST E EK T +P T E + EK PS A+
Sbjct: 984 GERTPLANENTTTSPTESTEHGERTANEKTTPSPAEPTEHGERTP--SANEKTIPSPAKP 1041
Query: 2079 DVDLCLVSSCEYKHPKTELSPSF---INPNPLEWFASEEPTEESEKPLTQSGGAPPPPGG 2135
E++PS P+P++ E T + + +T S P G
Sbjct: 1042 T-------------EHEEMTPSANENTTPSPVKPTEHGEKTTLANEKITLSPEGPTEHGA 1088
Query: 2136 KQQGRQCDETP----PTSVSESAPSQTD--SDVPPETEECPSITADANIDSEDESETIPT 2189
K TP PT E S D + E+ E AN+ + +E I
Sbjct: 1089 KTTSANEKITPSLAKPTEHGERTTSPNDKITSSAAESTEHRDRATSANVITPAPAEPIKH 1148
Query: 2190 DKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPG 2249
K T H Q S HP+ + EKT T+ P
Sbjct: 1149 AKRTTLAH----EKMTQVTEKSTEHPEKT------------------TSTTEKT-TRTPE 1185
Query: 2250 TKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASP-KKKESVEKAAKPTTT--P 2306
T S + GK+ P+ P L ++ + +P K E+ EK A T T P
Sbjct: 1186 KPTLYSEKTICTKGKNTPVPEKP-TENLGNTTLTTETIKAPVKSTENPEKTAAVTKTIKP 1244
Query: 2307 EVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSS 2348
VK + + + + T + T++T SS
Sbjct: 1245 SVKVTGDKSLTTTSSHLNKTEVTHQVPTGSFTLITSRTKLSS 1286
Score = 79.0 bits (193), Expect = 6e-14
Identities = 184/926 (19%), Positives = 302/926 (32%), Gaps = 84/926 (9%)
Query: 601 SVTEKEVPSKEEPSPVKAEVAEKQAT--DVKPKAAKEKTVKKETKVKPEDKKEEKEKPKK 658
+ E PS EP+ + A + T +P +E+T + T P E +E
Sbjct: 292 TANENNTPSPAEPTENRERTANENTTLSPAEPIENRERTANENTAPFPAGPTENREMTAN 351
Query: 659 EVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKE-------VKK 711
E P + E+ E + + E+ + P E
Sbjct: 352 ENTTLFPAEPTEHGERTANENTTPSPAEPTEHGERTANENTTPSPAEPTEHGERTPFAND 411
Query: 712 EVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSV 771
+ + + E+ P P A+ + A + P P + +
Sbjct: 412 KTTSSSAESTEHGERTPLANENTTPSPAEPTENRERTANENTTPSPAGPTENRETTANEK 471
Query: 772 AAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELE----AER 827
P E + + K + A G T ++ P + E A
Sbjct: 472 TTLSPVEPTENRETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLANE 531
Query: 828 SLMSSPEDLTKDFEELKAEEVDVTKDIKP-----QLELIEDEEKLKETEPVE-AYVIQKE 881
+ SP + T++ E A E +P + L ++ EP E
Sbjct: 532 NTTPSPAEPTEN-RERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENGQRTPFA 590
Query: 882 REVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGD 941
E T + P E T E TP EP E + E AG E+ E
Sbjct: 591 NEKTTSSSAEPTEHEERTPLANE-NTTPSPAEPTENRERTANENTTPSPAGPTENREMTA 649
Query: 942 YEEKA--ETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDR 999
E+ E E E E ++S PTE+ + + E G+
Sbjct: 650 NEKTTLFPAEPTENRERTANEKT--TSSPAEPTENGQRTPFANEKTTSSSAEPTEHGERT 707
Query: 1000 AEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAE 1059
+ + + E ++ E E K E E + A + + E G
Sbjct: 708 PLANENTTLSPAEPTENRERTANE-KTTPFPAEPTENRERTANENTTPSPAQPTENGDRT 766
Query: 1060 EQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSE----SEATASDEENREDQPEEFTA 1115
TTP+ ++ R P ++ ++T +E +E T EN P E T
Sbjct: 767 PLANEKTTPSLAEPTENGKRTPFAN--EKTTSSSAEPTEHAERTPLANENTTSSPAEPTE 824
Query: 1116 TSGYT--QSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVN---ITKYESSLY 1170
T + T + +EPT E + N + T P++ N ++L
Sbjct: 825 NRERTANEKTTQFPAEPTENRESTA---------NEKTTPFPAEPTENREWTANENTTLS 875
Query: 1171 SQEYSKPADVTPL-NGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCS 1229
E ++ ++TPL N + S + T+ + + + PSS E + R +
Sbjct: 876 PAEPTEHEEMTPLANEKTTLSPAEPTENGERTPFTNEKTTPSSAEPTEHGE---RTPLAN 932
Query: 1230 EVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVS 1289
E+ + + + +++EK +PS P + T GE +VN TP+ + +
Sbjct: 933 EITTPSRAEPTEHGERIANEKATPS-----------PAKPTEHGETTVNEDTTPSSAEPT 981
Query: 1290 AEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLP 1349
E P++ E T E E E +PS + G + S P
Sbjct: 982 ENGERTPLANENTTTSPTESTEHGERTANEKTTPSPAEPTEHGERTPSANEKTIPSPAKP 1041
Query: 1350 TEVIEKPPAVPVSFEFSDAKD---------ENERASVSP--MDEPVPDSESPIEKVLSPL 1398
TE E P+ + S K NE+ ++SP E + S EK+ L
Sbjct: 1042 TEHEEMTPSANENTTPSPVKPTEHGEKTTLANEKITLSPEGPTEHGAKTTSANEKITPSL 1101
Query: 1399 RSPPLIGSESAYESFLSADDKASGRGAESPFEE---KSGKQGSPDQVSPVSEMTSTSLYQ 1455
P G E S +DK + AES S +P P+ T+L
Sbjct: 1102 AKPTEHG-----ERTTSPNDKITSSAAESTEHRDRATSANVITPAPAEPIKHAKRTTLAH 1156
Query: 1456 DKQ---EGKSTDFAPIKEDFGQEKKT 1478
+K KST+ P K EK T
Sbjct: 1157 EKMTQVTEKSTEH-PEKTTSTTEKTT 1181
Score = 54.7 bits (130), Expect = 1e-06
Identities = 177/844 (20%), Positives = 289/844 (34%), Gaps = 143/844 (16%)
Query: 1566 TTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISP---P 1622
T+D + P G +S D + S + P + TE+ K C P P
Sbjct: 43 TSDHIFP---LTPGLVYSIPFDHIVLHSGQRPPELPKSTEIHEQKRHCNTTRHSKPTDKP 99
Query: 1623 DFSPKTAKSRTPVQDHRSEQSSMSIEFGQESP---EQSLAMDFSRQSPDHPTVGAGVLHI 1679
+ KT ++ +H + +S Q ++D + + H AG HI
Sbjct: 100 TGNSKTIDHKSSTDNHEAPPTSEENSSNQGKDPMIRNQRSVDPADSTTTHKE-SAGKKHI 158
Query: 1680 TENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPS 1739
T ++++ S S+++ K P + +S L S + +T+S H
Sbjct: 159 TPAPKSKINCRKSTTGKSTVTRKSDKTGRPL---EKSMSTLDKTS-TSSHKTTTSFHNSG 214
Query: 1740 QIASPLQEDTLSDVAPPRDMSLYASL-TSEKVQSLEGEKLSPKSDISPLTPRESSPLYSP 1798
+ + + + + Y + T E+ + E + + SD LT + +
Sbjct: 215 NSQTKQKSTSFPEKITAASKTTYKTTGTPEESEKTEDSRTTVASD-KLLTKTTKNIQETI 273
Query: 1799 TFSDSTSAVKEKTATCHSSSSPPIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEK 1858
+ ++ T ++ E T +++ + AEP R T + L+ E+
Sbjct: 274 SANELTQSLAEPTEHGGRTANENNTPSPAEPTENRER----TANENTTLSPAEPIENRER 329
Query: 1859 DSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSD 1918
+ T F + E T + + + E E RT++ E TT SP++
Sbjct: 330 TANENT-APFPAGPTENREMTANENTTLFPAEPTEHGERTAN---------ENTTPSPAE 379
Query: 1919 SGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSYDISEKTTSPPEVSGYSYEKTE 1978
E TP E E RTP ++KTTS S E TE
Sbjct: 380 PTEHGERTANENTTPSPA----EPTEHGERTPFA-------NDKTTSS------SAESTE 422
Query: 1979 RSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTS 2038
R ++N E+ + +P+ + E T + P G + T
Sbjct: 423 HGERT--PLAN-----ENTTPSPAEPTENRERTANENTTPSPAGPTENRETTAN------ 469
Query: 2039 TYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELS 2098
EK T +P T + ET+ EK +PS A TE
Sbjct: 470 -------EKTTLSPVEPTENRETT----ANEKTTPSPAEP----------------TENG 502
Query: 2099 PSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQT 2158
N +S EPTE E+ + P P + R+ T+ S + P++
Sbjct: 503 QRTPFANEKTTSSSAEPTEHGERTPLANENTTPSPAEPTENRERTANEKTTPSPAEPTEN 562
Query: 2159 DSDVPPETEE-CPSIT-----------ADANIDSEDESETIPTDKT-VTYKHMDPPPA-P 2204
P E+ PS+ A+ S T ++T + ++ P PA P
Sbjct: 563 GDRTPLANEKTTPSLAEPTENGQRTPFANEKTTSSSAEPTEHEERTPLANENTTPSPAEP 622
Query: 2205 VQDR--------SPSPRHPDVSMVDPEALAIEQ-NLGKALKKDLKEKTKTKK-------- 2247
++R +PSP P + E A E+ L A + +E+T +K
Sbjct: 623 TENRERTANENTTPSPAGPTENR---EMTANEKTTLFPAEPTENRERTANEKTTSSPAEP 679
Query: 2248 ---------PGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPK------- 2291
KT SSS G+ PLA E ++ R A+ K
Sbjct: 680 TENGQRTPFANEKTTSSSAEPTEHGERTPLANENTTLSPAEPTENRERTANEKTTPFPAE 739
Query: 2292 KKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGT----TKTTKS 2347
E+ E+ A TTP A+ E T A + A+ G T KTT S
Sbjct: 740 PTENRERTANENTTP--SPAQPTENGDRTPLANEKTTPSLAEPTENGKRTPFANEKTTSS 797
Query: 2348 SAVP 2351
SA P
Sbjct: 798 SAEP 801
Score = 52.0 bits (123), Expect = 7e-06
Identities = 83/388 (21%), Positives = 140/388 (36%), Gaps = 47/388 (12%)
Query: 1978 ERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDT 2037
E+S LD S + H G+ +T +K TSFPE + +T+ KTT TP+
Sbjct: 190 EKSMSTLDKTSTSSHKTTTSFHNSGNS----QTKQKSTSFPEKITAASKTTYKTTGTPEE 245
Query: 2038 STYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTEL 2097
S +T + T + T ++ E S +E Q + TE
Sbjct: 246 SE---KTEDSRTTVASDKLLTKTTKNI---QETISANELTQSL-----------AEPTEH 288
Query: 2098 SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETP------PTSVS 2151
N N + EPTE E+ ++ P + + R +E PT
Sbjct: 289 GGRTANENNTP--SPAEPTENRERTANENTTLSPAEPIENRERTANENTAPFPAGPTENR 346
Query: 2152 ESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPS 2211
E ++ + P E E TA+ N S PT+ + + P+P +
Sbjct: 347 EMTANENTTLFPAEPTEHGERTANEN---TTPSPAEPTEHGERTANENTTPSPAEPTEHG 403
Query: 2212 PRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAAS 2271
R P + D + ++ + L + T P T++ + +
Sbjct: 404 ERTPFAN--DKTTSSSAESTEHGERTPLANENTTPSPAEPTENRERTANEN-------TT 454
Query: 2272 PKPAGLKE----SSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANAS 2327
P PAG E ++++ + ++ + E+ E A TTP A E + T A +
Sbjct: 455 PSPAGPTENRETTANEKTTLSPVEPTENRETTANEKTTP--SPAEPTENGQRTPFANEKT 512
Query: 2328 ASKSAKTATAGPGTTKTTKSSAVPPGLP 2355
S SA+ G T +++ P P
Sbjct: 513 TSSSAEPTEHGERTPLANENTTPSPAEP 540
Score = 42.4 bits (98), Expect = 0.006
Identities = 35/131 (26%), Positives = 50/131 (38%), Gaps = 8/131 (6%)
Query: 560 ESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAE 619
ES E T N + P E + K + E VTEK S E P +
Sbjct: 1124 ESTEHRDRATSANVITPAPA----EPIKHAKRTTLAHEKMTQVTEK---STEHPEKTTST 1176
Query: 620 VAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKK-E 678
+ T KP EKT+ + K P +K + + + K P+K E P+K
Sbjct: 1177 TEKTTRTPEKPTLYSEKTICTKGKNTPVPEKPTENLGNTTLTTETIKAPVKSTENPEKTA 1236
Query: 679 EVKKEVKKEIK 689
V K +K +K
Sbjct: 1237 AVTKTIKPSVK 1247
Score = 40.8 bits (94), Expect = 0.017
Identities = 83/454 (18%), Positives = 153/454 (33%), Gaps = 37/454 (8%)
Query: 477 PANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ--------PLATQKDLTGQVPTP 528
PA P E R F T + E E + + P ++ + TP
Sbjct: 676 PAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLANENTTLSPAEPTENRERTANEKTTP 735
Query: 529 V-VKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEET-PEVTKVNHVEKPPKVESKEKV 586
+ T+ ++R + + A+P + + E+T P + + K +++
Sbjct: 736 FPAEPTENRERTANENTTPSPAQPTENGDRTPLANEKTTPSLAEPTENGKRTPFANEKTT 795
Query: 587 MVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATD--VKPKAAKEKTVKKETKV 644
+ E P E S EP+ + A ++ T +P +E T ++T
Sbjct: 796 SSSAEPTEHAERTPLANENTTSSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTP 855
Query: 645 KPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKET 704
P + E +E E P + EE K + E + +K T
Sbjct: 856 FPAEPTENREWTANENTTLSPAEPTEHEEMTPLANEKTTLSPAEPTENGERTPFTNEKTT 915
Query: 705 PPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEE 764
P + + E+ + E P + + + +E P+ KP E
Sbjct: 916 PSS--AEPTEHGERTPLANEITTPSR-----AEPTEHGERIANEKATPSPAKP-TEHGET 967
Query: 765 SVKKDSV-AAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKEL 823
+V +D+ ++ +P E G+ + E T +T A PA+
Sbjct: 968 TVNEDTTPSSAEPTENGERTPLANENTTTSP------TESTEHGERTANEKTTPSPAEPT 1021
Query: 824 E-AERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKER 882
E ER+ ++ + + + + EE + P +K TE E + E+
Sbjct: 1022 EHGERTPSANEKTIPSPAKPTEHEE------MTPSANENTTPSPVKPTEHGEKTTLANEK 1075
Query: 883 EVTKGPAESPDEGITTTEGEGECEQTPEELEPVE 916
+T P + G TT + TP +P E
Sbjct: 1076 -ITLSPEGPTEHGAKTTSANEKI--TPSLAKPTE 1106
Score = 39.7 bits (91), Expect = 0.037
Identities = 71/366 (19%), Positives = 126/366 (34%), Gaps = 38/366 (10%)
Query: 506 KHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQR--ADSRESLKPAAKPLPSKSVRKESKE 563
K F +P ++ + TP + + A+ +L PA E +E
Sbjct: 833 KTTQFPAEPTENRESTANEKTTPFPAEPTENREWTANENTTLSPAEPT--------EHEE 884
Query: 564 ETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPS--------VTEKEVPSKEEPSP 615
TP + + E+ E+ +K + +P+ E PS+ EP+
Sbjct: 885 MTPLANEKTTLSPAEPTENGERTPFTNEKTTPSSAEPTEHGERTPLANEITTPSRAEPTE 944
Query: 616 VKAEVAEKQAT--DVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKT-PIKKE 672
+A ++AT KP E TV ++T + E E + +A + T P +
Sbjct: 945 HGERIANEKATPSPAKPTEHGETTVNEDTTPSSAEPTENGE--RTPLANENTTTSPTEST 1002
Query: 673 EKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEI 732
E ++ +K + E E ++T P K + EE E P
Sbjct: 1003 EHGERTANEKTTPSPAEPTEHGERTPSANEKTIPSPA-KPTEHEEMTPSANENTTPS--- 1058
Query: 733 KKLPKDAKKSSTPLSEAKKPAALKPKVP-----KKEESVKKDSVAAGKPKEKGKIKVIKK 787
P + + A + L P+ P K + +K + + KP E G+ +
Sbjct: 1059 ---PVKPTEHGEKTTLANEKITLSPEGPTEHGAKTTSANEKITPSLAKPTEHGE-RTTSP 1114
Query: 788 EGKAAEAVAAAV--GTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKA 845
K + A + AT+A V+ A I AK M+ + + + E
Sbjct: 1115 NDKITSSAAESTEHRDRATSANVITPAPAEPIKHAKRTTLAHEKMTQVTEKSTEHPEKTT 1174
Query: 846 EEVDVT 851
+ T
Sbjct: 1175 STTEKT 1180
>gi|38788333 remodeling and spacing factor 1 [Homo sapiens]
Length = 1441
Score = 87.4 bits (215), Expect = 2e-16
Identities = 149/688 (21%), Positives = 262/688 (38%), Gaps = 109/688 (15%)
Query: 518 QKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKP 577
Q + + + P+ ++TK ++ +E K + K + T V + V+K
Sbjct: 220 QDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKE 279
Query: 578 PKVES---KEKVMVKKDKPI-KTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAA 633
+ E K V+VK +KP+ + E K + E+ KE P+K EV E +A K++
Sbjct: 280 KEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSS 339
Query: 634 KEKTVKKETK-------VKPEDKKEEKEKPKKEVAKKED--KTPIKKEEKPKKEEVKKEV 684
EK V +E + +K + EK + E K + K P+KK E ++ V
Sbjct: 340 MEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPV 399
Query: 685 K----------KEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPK----- 729
K KE K+E K+ ++ K+ + + E K+ EV E P
Sbjct: 400 KGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEP 459
Query: 730 -----KEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKV 784
E K+ K ++E +L + + + A + I V
Sbjct: 460 IETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISV 519
Query: 785 IKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELK 844
++ + A+ T+ + + AK+L ++ +L SS E T EE
Sbjct: 520 LEIHSQKAQIEEPDPPEMETS--------LDSSEMAKDLSSKTAL-SSTESCTMKGEEKS 570
Query: 845 AEEVDVTKDIKPQ-LELIEDEEKLKET-------------EPVEAYVIQKEREVTKGPAE 890
+ KD +P LE +E EK K+T E V ++ E+ + AE
Sbjct: 571 PK---TKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAE 627
Query: 891 -SPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYE------ 943
SP I CE+ E E VE Q + + E E ++
Sbjct: 628 TSPPSNIID-----HCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDN 682
Query: 944 -EKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRE-----SVASGD 997
+ A+T EEP E + + S K+ +EE+ +E E+++ ++
Sbjct: 683 LDNAQTSGIEEPSET-KGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISS 741
Query: 998 DRAEEDMDEAIEKGEAEQSEEEADEED------------------KAEDAREEEYEPEKM 1039
+ + D + + E +Q + E +EE K + R+++ + ++
Sbjct: 742 RKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRG 801
Query: 1040 EAEDYV------MAVVDKAAEAGGAEEQYGFLTTPTKQ------LGAQSPGREPASSIHD 1087
E ED V + DK +E+ + K G+++ GR SS +D
Sbjct: 802 EGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSS-ND 860
Query: 1088 ETLPGGSESEATASDEENREDQPEEFTA 1115
E+ GSE + AS+EE ++ E A
Sbjct: 861 ESEGSGSEKSSAASEEEEEKESEEAILA 888
Score = 84.0 bits (206), Expect = 2e-15
Identities = 146/662 (22%), Positives = 272/662 (41%), Gaps = 64/662 (9%)
Query: 628 VKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKK--EVK 685
+K + ++ + ++ ++ E+ K+E+E PK+E K+ +K +K EE+P E + V
Sbjct: 214 LKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEK--MKSEEQPMDLENRSTANVL 271
Query: 686 KEIKKEEKKEPKKE-------VKKETP-PKEVKKEVKKEEKKEVKKEEKEPKKEIKKL-- 735
+E +++KE +KE VK E P P+ +K++ KEE K+ K K E+K+
Sbjct: 272 EETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRA 331
Query: 736 -PKDAKKS-STPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPK--EKGKIKVIKKEGKA 791
PKD K S P+++ + + E +K + K K ++ KI + K+E K
Sbjct: 332 DPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKL 391
Query: 792 AEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVT 851
++ + V G +V K+ E +S+ L + ++L EV
Sbjct: 392 SDDFDSPV-KGPLCKSVTPTKEFLK-DEIKQEEETCKRISTITALGHEGKQLVNGEVS-D 448
Query: 852 KDIKPQLELIEDEEKLKETEPVEAYVIQKERE-VTKGPAESPDEGITTTEGEGECEQTPE 910
+ + P + E K ET+ E+Y K+R +T+G + T+ GE E +
Sbjct: 449 ERVAPNFKTEPIETKFYETKE-ESYSPSKDRNIITEGNGTESLNSVITSMKTGELE---K 504
Query: 911 ELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHS 970
E P+ K I E + E D E + ++ E +D +S+++
Sbjct: 505 ETAPLRKDADSSISVLEIHSQ--KAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESC 562
Query: 971 PTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAR 1030
+ EE + ++KR + ++ E+ ++K +A++ +E K+
Sbjct: 563 TMKGEEKSPKTK----KDKRPPILECLEKLEKSKKTFLDK-DAQRLSPIPEEVPKSTLES 617
Query: 1031 EEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETL 1090
E+ PE E ++D + +E +T T +G QS + ETL
Sbjct: 618 EKPGSPEAAETSP-PSNIIDHCEKLASEKEVVECQSTST--VGGQS-----VKKVDLETL 669
Query: 1091 PGGSESEATASDEENREDQPEEFTATSGYTQ-STIEISSEPTPMDEMSTPRDVMSDETNN 1149
+SE T + +N ++ TSG + S + S + + P + + N
Sbjct: 670 K--EDSEFTKVEMDNLDN-----AQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENT 722
Query: 1150 EETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISP 1209
E T +E + +T SS + S P + P N + KT+ + K SP
Sbjct: 723 EITSERQKEGIKLTIRISSRKKKPDSPPKVLEPEN---KQEKTEKEEEKTNVGRTLRRSP 779
Query: 1210 PSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAV----------SSEKVSPSKSPSL 1259
S K + +RD + + ++++ +A+ SEK + SK +
Sbjct: 780 RISRPTAKVAE--IRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKV 837
Query: 1260 SP 1261
P
Sbjct: 838 KP 839
Score = 76.6 bits (187), Expect = 3e-13
Identities = 205/1043 (19%), Positives = 382/1043 (36%), Gaps = 151/1043 (14%)
Query: 509 DFLKQPLATQKDLTGQVPTPVVKQTKLKQRAD---SRESLKPAAKPLPSKSVRKESKEET 565
+FLK + +++ ++ T + KQ + S E + P K P ++ E+KEE+
Sbjct: 412 EFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEES 471
Query: 566 PE-------VTKVNHVEKPPKVESKEKV--MVKKDKPIKTETKPSVTEKEVPSK----EE 612
+T+ N E V + K + K+ P++ + S++ E+ S+ EE
Sbjct: 472 YSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEE 531
Query: 613 PSPVKAEVA---EKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEK--PKKEVAKKEDKT 667
P P + E + + A D+ K A T K + + K +K+K P E +K +K+
Sbjct: 532 PDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKS 591
Query: 668 PIKKEEKPKKEEVKKEVKKEIKK---EEKKEPKKEVKKETPPKEV----KKEVKKEEKKE 720
KK K + + +E+ K E +K E + +PP + +K ++E E
Sbjct: 592 --KKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVE 649
Query: 721 VKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKG 780
+ + +KK+ + K + ++ + + EE K K
Sbjct: 650 CQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEP---SETKGSMQKSKF 706
Query: 781 KIKVIKKEGKAA----EAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAE--RSLMSSPE 834
K K++ +E A E + G +++ P K LE E + E
Sbjct: 707 KYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEE 766
Query: 835 DLTKDFEELKAE--------EVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQK--EREV 884
+ T L+ +V +D K + E E++++E E+ +QK ++E+
Sbjct: 767 EKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEE----ESTALQKTDKKEI 822
Query: 885 TKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEE 944
K + + ++ + +G+ T K +D E EG+G E+SS + EE
Sbjct: 823 LKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSND----ESEGSGSEKSSAASEEEE 878
Query: 945 KAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEA------DAYIREKRESVASGD- 997
+ E+EEA ++D C P E ++ A +R + G+
Sbjct: 879 EKESEEAILADDDEPCKKC-----GLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEW 933
Query: 998 -----------DRAEE---DMDEAIEKGEAEQSEEE--------------ADEEDKAEDA 1029
++ EE D+D A++K E + +E E D +ED
Sbjct: 934 FCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQ 993
Query: 1030 REEEYEPEKMEAE-----------------DYVMAVVDKAAE------AGGAEEQYGFLT 1066
E++ + +K +A D +D+A E GG + ++
Sbjct: 994 EEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDIS 1053
Query: 1067 TPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEI 1126
T T G + S+I DE + A+ + + + + S + E
Sbjct: 1054 TITGHRG------KDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDE---EE 1104
Query: 1127 SSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKP-------AD 1179
S + + + S V+SDE +E E P + T + S + S+P
Sbjct: 1105 SEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRR 1164
Query: 1180 VTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDI 1239
TP +S+ D + + N+ S +D R + + + D
Sbjct: 1165 KTPKKKYSD---DDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDS 1221
Query: 1240 KDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSP 1299
+ S S + + S E++ L + S + L + + +
Sbjct: 1222 ESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEY 1281
Query: 1300 EVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAV 1359
E EE P K L + + + H Q D + LP+E ++
Sbjct: 1282 SEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSE--QESTKK 1339
Query: 1360 PVSFEFSDAKD-ENERASVSPMDE-----PVPDSESP---IEKVL-SPLRSPPLIGSESA 1409
P E + +D EN SP+D P + +SP IE ++ P S
Sbjct: 1340 PYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNST 1399
Query: 1410 YESFLSADDKASGRGAESPFEEK 1432
+ L+++ + G+ A +P EE+
Sbjct: 1400 ASASLASNGTSGGQEAGAPEEEE 1422
Score = 60.8 bits (146), Expect = 2e-08
Identities = 168/827 (20%), Positives = 295/827 (35%), Gaps = 147/827 (17%)
Query: 498 ILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSV 557
ILE LEKL+ K L +P V K T ++ S E AA+ P ++
Sbjct: 581 ILECLEKLEKSK--KTFLDKDAQRLSPIPEEVPKSTLESEKPGSPE----AAETSPPSNI 634
Query: 558 -----RKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEE 612
+ S++E E + V V+ + +K+D ++ + EE
Sbjct: 635 IDHCEKLASEKEVVECQSTSTVGGQ-SVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEE 693
Query: 613 PSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEE-------KEKPKKEVAKKED 665
PS K + +K K +E T + T++ E +KE + KK + +
Sbjct: 694 PSETKGSM-QKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKV 752
Query: 666 KTPIKKEEKPKKEEVKKEVKKEIKKE--------------EKKEPKKEVKKETPPKEVKK 711
P K+EK +KEE K V + +++ ++K KK + E +E
Sbjct: 753 LEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEEST 812
Query: 712 EVKKEEKKEV-KKEEKEPKKEIKKLPKDAKKSST-----------PLSEAKKPAALKPKV 759
++K +KKE+ KK EK+ ++ K+ K T E++ + K
Sbjct: 813 ALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSA 872
Query: 760 PKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIG- 818
+EE K+ A ++ K + + +G TA + I G
Sbjct: 873 ASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGE 932
Query: 819 ----PAKELEAERSLMSSPEDL-----TKDFEELKAEE-----VDVTKDIKPQ-LELIED 863
P + L +DL K+ E + E + + I PQ + ED
Sbjct: 933 WFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSED 992
Query: 864 -EEKLKETEPVEAYVIQKEREVTKGPA--------ESPDEGI--TTTEGEGECEQTPEEL 912
EEK K+++ +A ++++ T+ E+ DE I E +G +++
Sbjct: 993 QEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDI 1052
Query: 913 EPVEKQGVDDIEKFEDE------------GAGFEESSETGDYEEKAETEEAEEPEE---- 956
+ DI DE A ++ D + + +E E +E
Sbjct: 1053 STITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKIS 1112
Query: 957 DGEEHVCVSASKHSPTEDEESAKAEADA---------------------YIREKRESVAS 995
DG + V S +P E EE + D+ +R K
Sbjct: 1113 DGSQDEFV-VSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKY 1171
Query: 996 GDDRAEEDMDEAIEKGEAEQSEEEADE--EDKAEDAR-------------EEEYEPEKME 1040
DD EE+ +E E++ S++ +D+ E + +R E + + +
Sbjct: 1172 SDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLR 1231
Query: 1041 AEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATA 1100
+ V + + +EE Y + +L +E S+ G S E +
Sbjct: 1232 RGKEIRRVHKRRLSSSESEESYLSKNSEDDEL-----AKESKRSVRKR---GRSTDEYSE 1283
Query: 1101 SDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSD--ETNNEETESP--- 1155
+DEE E++ + ++ E S + D RD + E T+ P
Sbjct: 1284 ADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYRI 1343
Query: 1156 ----SQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGK 1198
++F N+ K S L +YS D+ NG S G + GK
Sbjct: 1344 ESDEEEDFENVGKVGSPL---DYSL-VDLPSTNGQSPGKAIENLIGK 1386
Score = 52.0 bits (123), Expect = 7e-06
Identities = 137/646 (21%), Positives = 230/646 (35%), Gaps = 153/646 (23%)
Query: 520 DLTGQVPTPVVKQTKLK-QRADSRESLK-----PAAKPLPSKSVRKESKEETPEVTKVNH 573
DL + V+++T +K ++ D +E +K KPLP +K KEE+ K N
Sbjct: 261 DLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSF-KEN- 318
Query: 574 VEKPPKVESKEKVMVKKD------KPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATD 627
KP KVE KE KD KP+ E + + S E + E EK D
Sbjct: 319 -VKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKND 377
Query: 628 VKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKED--KTPIKKEEKPKKE------- 678
+ AK K+E K+ + K K V ++ K IK+EE+ K
Sbjct: 378 ---QQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITAL 434
Query: 679 --EVKKEVKKEIK--------------------KEEKKEPKK------------------ 698
E K+ V E+ KEE P K
Sbjct: 435 GHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVI 494
Query: 699 ------EVKKETPP--KEVKKEV-------KKEEKKEVKKEEKEPKKEIKKLPKD----- 738
E++KET P K+ + +K + +E E E + ++ KD
Sbjct: 495 TSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKT 554
Query: 739 ---AKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAV 795
+ +S T E K P K K P E ++K EK K + K+ + +
Sbjct: 555 ALSSTESCTMKGEEKSPKTKKDKRPPILECLEK--------LEKSKKTFLDKDAQRLSPI 606
Query: 796 AAAVGTGATTAAVMAAAGIAAIGP-------AKELEAERSLMSSPEDLTKDFEELKAEEV 848
V + + A P ++L +E+ ++ T + +K ++
Sbjct: 607 PEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDL 666
Query: 849 DVTKD----IKPQLELIEDEEKLKETEPVEA----------YVIQKEREVTKGP-----A 889
+ K+ K +++ +++ + EP E Y + E E T +
Sbjct: 667 ETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITS 726
Query: 890 ESPDEGITTT----EGEGECEQTPEELEPVEKQGVDDIEKFEDE---GAGFEESSETGDY 942
E EGI T + + + P+ LEP KQ + EK E++ G S
Sbjct: 727 ERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQ--EKTEKEEEKTNVGRTLRRSPRISRP 784
Query: 943 EEKA---ETEEAEEPEEDGEEHVCVSASKHSPTEDEESAK-AEADAYIREKRESVA---- 994
K ++A++ +GE+ V ++ T+ +E K +E D + +
Sbjct: 785 TAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVR 844
Query: 995 ------------SGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAED 1028
S +D +E E E+ E+E++E A+D
Sbjct: 845 WTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADD 890
Score = 42.7 bits (99), Expect = 0.004
Identities = 130/663 (19%), Positives = 234/663 (35%), Gaps = 114/663 (17%)
Query: 952 EEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYI--------REKRESVASGDD--RAE 1001
E+ ++DG C+ +++ E KA+ D + RES + D+ + E
Sbjct: 179 EQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKE 238
Query: 1002 EDMDEAIEKGEAEQ---SEEEADEEDKA------EDAREEEYEPEKMEAEDYVMAVVDK- 1051
E+ + E+ E+E+ E+ D E+++ E ++E E EK + V+ ++K
Sbjct: 239 EETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKP 298
Query: 1052 ----------AAEAGGAEEQYGFLTTPTKQLGA-----QSPGREPASSIHDETLPGG--- 1093
E+ +E + K+ A +S +P + + GG
Sbjct: 299 LPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIK 358
Query: 1094 SESEATASDEENREDQPEEFTATSGYTQSTIEISSE-----PTPMDEMSTP-RDVMSDET 1147
S E T E E + A + I++S + P+ + TP ++ + DE
Sbjct: 359 SSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEI 418
Query: 1148 NNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTI 1207
EE + +E V P KT+ + K Y +
Sbjct: 419 KQEEETCKRISTITALGHEGKQLVNGEVSDERVAP------NFKTEPIETKFYETKEESY 472
Query: 1208 SPPSSM------EEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSP 1261
SP + S + E++ T KD+ S++S ++ K+ P
Sbjct: 473 SPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEP 532
Query: 1262 SPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPE-VTQEVVEEHCASPEDKTLEV 1320
PP + SL +E+ ++ A S E T + E+ + +DK +
Sbjct: 533 DPP-----------EMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPI 581
Query: 1321 VSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPM 1380
+ + + S + ++ S +P E VP S S+ E A SP
Sbjct: 582 LECLEKLEKS---KKTFLDKDAQRLSPIPEE-------VPKSTLESEKPGSPEAAETSPP 631
Query: 1381 DEPVPDSES-PIEKVLSPLRSPPLIGSESAYE---SFLSAD-----------DKASGRGA 1425
+ E EK + +S +G +S + L D D A G
Sbjct: 632 SNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGI 691
Query: 1426 ESPFEEKSGKQGS-------PDQVSPVSEMTSTSLYQDKQ----------EGKSTDFAP- 1467
E P E K Q S P++ + SE T + + K+ K D P
Sbjct: 692 EEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPK 751
Query: 1468 IKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVS 1527
+ E +++KT+ E ++ + R+ +S V++ K D K E V
Sbjct: 752 VLEPENKQEKTEKEEEKTN---VGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVE 808
Query: 1528 DKS 1530
++S
Sbjct: 809 EES 811
Score = 36.6 bits (83), Expect = 0.31
Identities = 86/440 (19%), Positives = 173/440 (39%), Gaps = 61/440 (13%)
Query: 1369 KDENERASVSPMDEP-------VPDSESPIEKVLSPLRS---PPLIGSESAYESFLSADD 1418
+D N R + D+ + + + + + L+ L++ P L+ + S ++ S+ +
Sbjct: 169 QDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDN--SSRE 226
Query: 1419 KASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKT 1478
S E+ EE++ KQ + SE + E +ST A + E+ +K+
Sbjct: 227 SPSLEDEETKKEEETPKQEEQKE----SEKMKSEEQPMDLENRST--ANVLEETTVKKEK 280
Query: 1479 DDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTK---MSISEGTVSDKSATPVD 1535
+D + + P + E+ L + +I + SFKE+ K + + E K
Sbjct: 281 EDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSM 340
Query: 1536 EGVAEDTYSHMEGVASVSTASVATSSFPEPTT---DDVSPSL-----HAEVGSPHSTEVD 1587
E +E ++ ++ T E T +D + ++ + V
Sbjct: 341 EKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVK 400
Query: 1588 DSLSVSVVQTPTT-FQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS----EQ 1642
L SV TPT F + E+ +E C R +I+ K + V D R +
Sbjct: 401 GPLCKSV--TPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGE-VSDERVAPNFKT 457
Query: 1643 SSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHK 1702
+ +F E+ E+S + S D + G NG ++ + M+ L +
Sbjct: 458 EPIETKF-YETKEESYS-----PSKDRNIITEG------NGTESLNSVITSMKTGELEKE 505
Query: 1703 IPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLY 1762
P+ + D ISV ++ + + P ++ + L ++ +D+S
Sbjct: 506 TAPLRK-------DADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMA-----KDLSSK 553
Query: 1763 ASLTSEKVQSLEGEKLSPKS 1782
+L+S + +++GE+ SPK+
Sbjct: 554 TALSSTESCTMKGEEKSPKT 573
>gi|239754668 PREDICTED: mucin 12 [Homo sapiens]
Length = 1952
Score = 87.4 bits (215), Expect = 2e-16
Identities = 298/1395 (21%), Positives = 447/1395 (32%), Gaps = 284/1395 (20%)
Query: 1065 LTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTI 1124
L+ + GA+ R+ SS D SE TA+ E F+ S T ST+
Sbjct: 38 LSEQARAAGAREKERQEVSSSPDV-------SELTATKHEETVINHSTFSGFSQITGSTV 90
Query: 1125 EISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLN 1184
S + T + T S S F + Y S+ S +
Sbjct: 91 NTS---------------IGGNTTSASTPSSSDPFTTFSDYGVSVTFITGSTATKHFLDS 135
Query: 1185 GFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSIS 1244
+ G ++T + T PS F S +T L + +
Sbjct: 136 STNSGHSEESTVSHSGPGATGTTLFPSHSATSVFVGEPKTSPITSASMETTALPGSTTTA 195
Query: 1245 AVSSEKVSPSKSPSLSPSPPSPLEKTPLG--ERSVNFSLTPNEIKVSAEAEVAPVSPEVT 1302
+S + + SP SP T G E+S P A + + P V+
Sbjct: 196 GLSEKSTTFYSSPRSPDRTLSPARTTSSGVSEKSTTSHSRPGPTHTIAFPD-STTMPGVS 254
Query: 1303 QEVVEEHCASPEDKTLEVVSPSQSVTGSAG--HTPYYQSPTDEKSSHLPTEVIEKPPAVP 1360
QE H S T +SP + S G T ++ SP K++ LP
Sbjct: 255 QESTASH--SIPGSTDTTLSPGTTTPSSLGPESTTFHSSPGYTKTTRLP----------- 301
Query: 1361 VSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKA 1420
D + + PV S LSP S G + ++S+ S+ D +
Sbjct: 302 ---------DNTTTSGLLEASTPVHSSTGSPHTTLSPASSTTHEGEPTTFQSWPSSKDTS 352
Query: 1421 SGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDD 1480
+P + ST+ + +T F+ G +++
Sbjct: 353 P----------------APSGTTSAFVKLSTTYHSSPSSTPTTHFSASSTTLGHSEESTP 396
Query: 1481 VEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAE 1540
V SS A A +P + G +E T S G S + +
Sbjct: 397 VH--SSPVATA--------TTPPPARSATSGHVEESTAYHRSPG-----STQTMHFPESS 441
Query: 1541 DTYSHMEGVASVSTASVAT-SSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVS------ 1593
T H E A+ ++ T SS P T S H+ +GS +T DS ++S
Sbjct: 442 TTSGHSEESATFHGSTTHTKSSTPSTTAALAHTSYHSSLGSTETTHFRDSSTISGRSEES 501
Query: 1594 ----------------VVQTPTTF-QETEMSP----SKEECPRPMSISPPDFSPKT---- 1628
TP+ ++ SP S E P S + P S K+
Sbjct: 502 KASHSSPDAMATTVLPAGSTPSVLVGDSTPSPISSGSMETTALPGSTTKPGLSEKSTTFY 561
Query: 1629 AKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHI--------- 1679
+ R+P H + S + SR H T G +
Sbjct: 562 SSPRSPDTTHLPASMTSS------GVSEESTTSHSRPGSTHTTAFPGSTTMPGLSQESTA 615
Query: 1680 --TENGPTEVDYSPSDMQDSSLS------HKIPPMEEPSYTQDNDLSELISVSQVEASPS 1731
+ GPT+ SP SSL H P E + DN + + + + S
Sbjct: 616 SHSSPGPTDTTLSPGSTTASSLGPEYTTFHSRPGSTETTLLPDNTTASGLLEASMPVHSS 675
Query: 1732 TSSAHTPSQIAS--------------PLQEDTLSDVAPPRDMSLYA--SLTSE-KVQSLE 1774
T S HT A P DT APP S + S TS S+
Sbjct: 676 TRSPHTTLSPAGSTTRQGESTTFHSWPSSNDTRP--APPTTTSAFVEPSTTSHGSPSSIP 733
Query: 1775 GEKLSPKSDISPL----TPRESSPLYSPTF----SDSTSAVKEKTATCHSSSSPPIDAAS 1826
+S +S S L T SSP + T SD+TS E++ T HSS++ I +A
Sbjct: 734 TTHISARSTTSGLVEESTTYHSSPGSTQTMHFPESDTTSGRGEESTTSHSSTTHTISSAP 793
Query: 1827 AEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGKTPGDFSYAYQKPEETTRSPDEED 1886
+ S L + E S +PG + + TT EE
Sbjct: 794 S-----TTSALVE-----------------EPTSYHSSPGSTATTHFPDSSTTSGRSEES 831
Query: 1887 YDYESYEKTTRTSDVGGYYYEKI--ERTTKSPSDSGYSYETIGKTTKTPEDGDYSYEIIE 1944
S + T T + + +T SP SG S ET T G + E
Sbjct: 832 IASHSSQDATGTIVLPARSTNSVLLGESTTSPISSG-SMETTALPGSTTTPG-----LSE 885
Query: 1945 KTTRTPEEGGYSYDISEKTTSPP---EVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTL 2001
++T +S S TT P SG S E T R + + DS
Sbjct: 886 RSTTF-----HSSPRSPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDS------- 933
Query: 2002 GDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYET 2061
TT S + +S ST TT P ++T + T +P S+ S ET
Sbjct: 934 --------TTTPGLSRHSTTSHSSPGSTDTTLLPASTT--TXLVGEPTTSP-ISSGSTET 982
Query: 2062 SDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPK---TELSPSFINPNPLEWFASEEPTEE 2118
+ L + SE S+ Y P+ T LSP+ + + SEE T
Sbjct: 983 TALPGSTTTAGLSEK---------STTFYSSPRSPDTTLSPASTTSSGV----SEESTTS 1029
Query: 2119 SEKP----LTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITA 2174
+P T G+ PG Q+ ++ S S+P TD+ + P + S+
Sbjct: 1030 HSRPGSTHTTAFPGSTTMPGVSQE---------STASHSSPGSTDTTLSPRSTTASSLGP 1080
Query: 2175 DANI--DSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLG 2232
++ +ET T + PV + SPR + + P Q
Sbjct: 1081 ESTTFHSGPGSTETTLLPDNTTASGLLEASTPVHSSTGSPR----TTLSPAGSTTRQGES 1136
Query: 2233 KALKKDLKEKTKTKKPGTKTK-------------SSSPVKKSDGKSKPLAASPKPAGLKE 2279
+ K P T T SS P S S + +
Sbjct: 1137 TTFQSWPSSKDTMPAPPTTTSAFVELSTTSHGSPSSIPTTHFSASSTTFGRSEESTTVHS 1196
Query: 2280 SSDKVSRVASPKK-------KESVEKAAKPTTT-----PEVKAARGEEKDKETKNAANAS 2327
S + SP + +ES + P +T PE A G ++ T S
Sbjct: 1197 SPVAPATTPSPARSTTSGLVEESTAYHSSPGSTQTMHFPESSTASGRSEESRT------S 1250
Query: 2328 ASKSAKTATAGPGTT 2342
S + T ++ P TT
Sbjct: 1251 HSSTTHTISSPPSTT 1265
Score = 73.2 bits (178), Expect = 3e-12
Identities = 167/810 (20%), Positives = 280/810 (34%), Gaps = 98/810 (12%)
Query: 1076 SPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDE 1135
SPG + D + G E+ AS + +D + T S + S +P+
Sbjct: 809 SPGSTATTHFPDSSTTSGRSEESIAS--HSSQDATGTIVLPARSTNSVLLGESTTSPISS 866
Query: 1136 MSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDAT 1195
S + T +++ ++ +S S ++P + S G ++T
Sbjct: 867 GSMETTALPGSTTTP----------GLSERSTTFHSSPRSPATTLSPASTTSSGVSEEST 916
Query: 1196 DGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSK 1255
S T + P S SR + +T L + V SP
Sbjct: 917 TSHSRPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTXLVGEPTTSPIS 976
Query: 1256 SPSLSPSP-PSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPE---VTQEVVEEHC- 1310
S S + P L E+S F +P S + ++P S V++E H
Sbjct: 977 SGSTETTALPGSTTTAGLSEKSTTFYSSPR----SPDTTLSPASTTSSGVSEESTTSHSR 1032
Query: 1311 -------ASPEDKTLEVVSPSQSVTGSA-GHTPYYQSPTDEKSSHLPTEVIEKPPAVPVS 1362
A P T+ VS + + S+ G T SP +S L E P S
Sbjct: 1033 PGSTHTTAFPGSTTMPGVSQESTASHSSPGSTDTTLSPRSTTASSLGPESTTFHSG-PGS 1091
Query: 1363 FEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDK--A 1420
E + D + + PV S LSP S G + ++S+ S+ D A
Sbjct: 1092 TETTLLPDNTTASGLLEASTPVHSSTGSPRTTLSPAGSTTRQGESTTFQSWPSSKDTMPA 1151
Query: 1421 SGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDD 1480
+ E + GSP + S++ + +E + +P+ T
Sbjct: 1152 PPTTTSAFVELSTTSHGSPSSIPTTHFSASSTTFGRSEESTTVHSSPVAP------ATTP 1205
Query: 1481 VEAMSSQPALALDERKLGDVSPTQIDVSQF------GSFKEDTKMSISEGTVSDKSATPV 1534
A S+ L ++E SP F E+++ S S T + S
Sbjct: 1206 SPARSTTSGL-VEESTAYHSSPGSTQTMHFPESSTASGRSEESRTSHSSTTHTISSPPST 1264
Query: 1535 DEGVAEDTYSHMEGVASVSTASVATSSFPEPTT----DDVSPSLHAEVGSPHSTEVDDSL 1590
+ E+ S+ S S+AT+ FPE +T + S + H+ + T +
Sbjct: 1265 TSALVEEPTSYHS-----SPGSIATTHFPESSTTSGRSEESTASHSSPDTNGITPLPAHF 1319
Query: 1591 SVSV-VQTPTTFQETEMSPSKEECPRPMSISPPDFSPKT----AKSRTPVQDHRSEQSSM 1645
+ S + TTF +SP E + + P S K+ + SR+P Q +
Sbjct: 1320 TTSGRIAESTTFY---ISPGSMETTLASTATTPGLSAKSTILYSSSRSPDQTLSPASMTS 1376
Query: 1646 SIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITEN-----GPTEVDYSPSDMQDSSLS 1700
S G+ + S A + T +G+ + G TE SP + SS +
Sbjct: 1377 SSISGEPTSLYSQAESTHTTAFPASTTTSGLSQESTTFHSKPGSTETTLSPGSITTSSFA 1436
Query: 1701 HKIPPMEE----------PSYTQDNDLSELISV--SQVEASPSTSSAHTPSQIASPLQED 1748
+ P+ T LSE + S ++ +T+ +H+ + Q
Sbjct: 1437 QEFTTPHSQPGSALSTVSPASTTVPGLSEESTTFYSSPGSTETTAFSHSNTMSIHSQQST 1496
Query: 1749 TLSDVAPPRDMSLYASLTSEKV--QSLEGEKLSPKSDISPLTPRES-------------- 1792
D L A+LT+ + +S S + +PL R +
Sbjct: 1497 PFPDSPGFTHTVLPATLTTTDIGQESTAFHSSSDATGTTPLPARSTASDLVGEPTTFYIS 1556
Query: 1793 -SPLYSPTF--SDSTSAVKEKTATCHSSSS 1819
SP Y+ F S STS + E++ T H+S S
Sbjct: 1557 PSPTYTTLFPASSSTSGLTEESTTFHTSPS 1586
Score = 54.7 bits (130), Expect = 1e-06
Identities = 178/903 (19%), Positives = 307/903 (33%), Gaps = 109/903 (12%)
Query: 1066 TTPTKQLGAQSPGREPASSIHDETLPGGS-----ESEATASDEENREDQPEEFTATSGY- 1119
TT + L A P S H P GS ES S + + +P T TS +
Sbjct: 660 TTASGLLEASMPVHSSTRSPHTTLSPAGSTTRQGESTTFHSWPSSNDTRPAPPTTTSAFV 719
Query: 1120 ---TQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSK 1176
T S SS PT + + +E+ + S + ++ + +++ E S
Sbjct: 720 EPSTTSHGSPSSIPTTHISARSTTSGLVEESTTYHSSPGSTQTMHFPESDTTSGRGEEST 779
Query: 1177 PADVTPLNGFSEGSKTDAT---DGKDYNAS----ASTISPPSSMEEDKFSRSALRDAYCS 1229
+ + + S T + + Y++S A+T P SS + S ++
Sbjct: 780 TSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGR-SEESIASHSSQ 838
Query: 1230 EVKASTTLDIKDSISAVSSEKV-SPSKSPSLSPSPPSPLEKTP-LGERSVNFSLTPNEIK 1287
+ + L + + S + E SP S S+ + TP L ERS F +P
Sbjct: 839 DATGTIVLPARSTNSVLLGESTTSPISSGSMETTALPGSTTTPGLSERSTTFHSSPRS-P 897
Query: 1288 VSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGH-TPYYQSPTDEKSS 1346
+ + + S V++E H + P S + G + H T + SP ++
Sbjct: 898 ATTLSPASTTSSGVSEESTTSH-SRPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTT 956
Query: 1347 HLP----TEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPP 1402
LP T ++ +P P+S E ++ SE SP
Sbjct: 957 LLPASTTTXLVGEPTTSPIS------SGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDT 1010
Query: 1403 LIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKS 1462
+ S S +S EE + P + ST++ QE +
Sbjct: 1011 TLSPASTTSSGVS--------------EESTTSHSRPGSTHTTAFPGSTTMPGVSQESTA 1056
Query: 1463 TDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSIS 1522
+ +P D ++ ++ + + + + + G + T + S
Sbjct: 1057 SHSSPGSTDTTLSPRSTTASSLGPESTTFHSGPGSTETTLLPDNTTASGLLEASTPVHSS 1116
Query: 1523 EG---TVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVG 1579
G T + + +G + S ++ TS+F E +T G
Sbjct: 1117 TGSPRTTLSPAGSTTRQGESTTFQSWPSSKDTMPAPPTTTSAFVELST--------TSHG 1168
Query: 1580 SPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHR 1639
SP S + S TTF +E S + P + +P SP + + V++
Sbjct: 1169 SPSSIPTTHFSASS-----TTFGRSEESTTVHSSPVAPATTP---SPARSTTSGLVEEST 1220
Query: 1640 SEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDY---SPSDMQD 1696
+ SS PE S A S +S + T + H + P+ P+
Sbjct: 1221 AYHSSPGSTQTMHFPESSTA---SGRSEESRTSHSSTTHTISSPPSTTSALVEEPTSYHS 1277
Query: 1697 SSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTS-SAH----------TPSQIASPL 1745
S S E S T S S + + T AH T I+
Sbjct: 1278 SPGSIATTHFPESSTTSGRSEESTASHSSPDTNGITPLPAHFTTSGRIAESTTFYISPGS 1337
Query: 1746 QEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPT------ 1799
E TL+ A +S +++ +S + + LSP S S E + LYS
Sbjct: 1338 METTLASTATTPGLSAKSTILYSSSRSPD-QTLSPASMTSSSISGEPTSLYSQAESTHTT 1396
Query: 1800 ---FSDSTSAVKEKTATCHS---SSSPPIDAASAEPYGFRASVLFDTMQHHLALN----R 1849
S +TS + +++ T HS S+ + S F Q AL+
Sbjct: 1397 AFPASTTTSGLSQESTTFHSKPGSTETTLSPGSITTSSFAQEFTTPHSQPGSALSTVSPA 1456
Query: 1850 DLSTPGLEKDS-------GGKTPGDFSYAYQ---KPEETTRSPDEEDYDYESYEKTTRTS 1899
+ PGL ++S G FS++ +++T PD + + T T+
Sbjct: 1457 STTVPGLSEESTTFYSSPGSTETTAFSHSNTMSIHSQQSTPFPDSPGFTHTVLPATLTTT 1516
Query: 1900 DVG 1902
D+G
Sbjct: 1517 DIG 1519
Score = 43.9 bits (102), Expect = 0.002
Identities = 141/667 (21%), Positives = 213/667 (31%), Gaps = 145/667 (21%)
Query: 1047 AVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDE------------------ 1088
A+ AG +E+ F ++P SP +S + +E
Sbjct: 984 ALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPG 1043
Query: 1089 --TLPGGSESEATASDEENRED---QPEEFTATSGYTQSTI----EISSEPTPMDEMSTP 1139
T+PG S+ + D P TA+S +ST S+E T + + +T
Sbjct: 1044 STTMPGVSQESTASHSSPGSTDTTLSPRSTTASSLGPESTTFHSGPGSTETTLLPDNTTA 1103
Query: 1140 RDVMSDETN-NEETESPSQEFV---NITKYESSLYSQEYSKPADVTPLNGFSEGSKTDAT 1195
++ T + T SP + T+ S Q + D P T
Sbjct: 1104 SGLLEASTPVHSSTGSPRTTLSPAGSTTRQGESTTFQSWPSSKDTMPA--------PPTT 1155
Query: 1196 DGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSK 1255
S ++ PSS+ FS S STT + + V S V+P+
Sbjct: 1156 TSAFVELSTTSHGSPSSIPTTHFSAS------------STTFGRSEESTTVHSSPVAPAT 1203
Query: 1256 SPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPED 1315
+PS + S S L E S + +P + E + S E +
Sbjct: 1204 TPSPARSTTSGLV-----EESTAYHSSPGSTQTMHFPESSTASGR------SEESRTSHS 1252
Query: 1316 KTLEVVSPSQSVTGSAGHTP--YYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENE 1373
T +S S T + P Y+ SP ++H P + + E
Sbjct: 1253 STTHTISSPPSTTSALVEEPTSYHSSPGSIATTHFPES------------STTSGRSEES 1300
Query: 1374 RASVSPMDE----PVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPF 1429
AS S D P+P + ++ S S + E+ L++ G A+S
Sbjct: 1301 TASHSSPDTNGITPLPAHFTTSGRIAE---STTFYISPGSMETTLASTATTPGLSAKSTI 1357
Query: 1430 EEKSGKQGSPDQVSPVSEMTS-------TSLYQDKQEGKSTDFAPIKEDFG--QEKKTDD 1480
S + SPDQ + MTS TSLY + +T F G QE T
Sbjct: 1358 LYSSSR--SPDQTLSPASMTSSSISGEPTSLYSQAESTHTTAFPASTTTSGLSQESTTFH 1415
Query: 1481 VEAMSSQPALALDE------------------RKLGDVSPTQIDV--------------- 1507
+ S++ L+ L VSP V
Sbjct: 1416 SKPGSTETTLSPGSITTSSFAQEFTTPHSQPGSALSTVSPASTTVPGLSEESTTFYSSPG 1475
Query: 1508 -SQFGSFKEDTKMSI----------SEG---TVSDKSATPVD---EGVAEDTYSHMEGVA 1550
++ +F MSI S G TV + T D E A + S G
Sbjct: 1476 STETTAFSHSNTMSIHSQQSTPFPDSPGFTHTVLPATLTTTDIGQESTAFHSSSDATGTT 1535
Query: 1551 SVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVV-QTPTTFQETEMSPS 1609
+ S A+ EPTT +SPS P S+ S T +F T +S
Sbjct: 1536 PLPARSTASDLVGEPTTFYISPSPTYTTLFPASSSTSGLTEESTTFHTSPSFTSTIVSTE 1595
Query: 1610 KEECPRP 1616
E P
Sbjct: 1596 SLETLAP 1602
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 86.7 bits (213), Expect = 3e-16
Identities = 115/551 (20%), Positives = 197/551 (35%), Gaps = 74/551 (13%)
Query: 524 QVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESK 583
+V P K+ + + K AAK S S + S ++ E K V+K K ++K
Sbjct: 96 EVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAK 155
Query: 584 EKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVK---- 639
K S +E E P ++P V + KP A K
Sbjct: 156 AAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAA 215
Query: 640 -----KETKVKPEDKKEEKEK--PKKEVAKKE--DKTPIKKEEKPKKEEVKKEVKKEIKK 690
+ +D +EEK PKK V KK+ K P+K P ++ E ++
Sbjct: 216 SSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEE 275
Query: 691 EEKKEP-------------------KKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKE 731
EE+K+P KK + + P K V+K+ E ++ E +E
Sbjct: 276 EEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEE 335
Query: 732 IKKLPKDA--KKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEG 789
KK P A K++T AKK A + + +D A KP G
Sbjct: 336 EKKPPTKAVVSKATTKPPPAKK--AAESSSDSSDSDSSEDDEAPSKP-----------AG 382
Query: 790 KAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVD 849
+ T + A AAA +G ++L ++ SS E+ + EE K +++
Sbjct: 383 TTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMV 442
Query: 850 VTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTP 909
T KP+ + PA+ +G + + + +
Sbjct: 443 AT--TKPK---------------------ATAKAALSLPAKQAPQGSRDSSSDSDSSSSE 479
Query: 910 EELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKH 969
EE E K V +K + G S + KAE+ + ++ EE K
Sbjct: 480 EEEEKTSKSAVK--KKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKG 537
Query: 970 SPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDA 1029
SP ++ KA + + + A + EE+ +A S ++ + + A++A
Sbjct: 538 SPR--PQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEA 595
Query: 1030 REEEYEPEKME 1040
+ + K++
Sbjct: 596 ETPQAKKIKLQ 606
Score = 69.3 bits (168), Expect = 4e-11
Identities = 126/611 (20%), Positives = 243/611 (39%), Gaps = 85/611 (13%)
Query: 618 AEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKK 677
A+V E++ P A K K KK + ED EE+E+ + AKK P K+ P
Sbjct: 61 AKVPERKLQANGPVAKKAK--KKASSSDSEDSSEEEEEVQGPPAKKA-AVPAKRVGLPPG 117
Query: 678 EEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPK 737
+ K + +E + +E +K+ P V+K VK + K K P K+ K
Sbjct: 118 KAAAKASESSSSEESSDDDDEEDQKKQP---VQKGVKPQ-----AKAAKAPPKKAKSSDS 169
Query: 738 DAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKP-KEKGKIKVIKKEGKAAEAVA 796
D+ S SE + P KPK+ +VK + A KP + KI GKAA +
Sbjct: 170 DSDSS----SEDEPPKNQKPKI--TPVTVKAQTKAPPKPARAAPKI----ANGKAA---S 216
Query: 797 AAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKP 856
++ + +++++ + AA P K + ++ + +P +KA K
Sbjct: 217 SSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAP---------VKAATTPTRKSSSS 267
Query: 857 QLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVE 916
+ ++EE+ K K + GP S P P +
Sbjct: 268 EDSSSDEEEEQK-----------KPMKNKPGPYSS--------------VPPPSAPPPKK 302
Query: 917 KQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEE 976
G +K ++ E S ++ D + + EE + P + VS + P ++
Sbjct: 303 SLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTK-----AVVSKATTKPPPAKK 357
Query: 977 SAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEP 1036
+A++ +D +S D +E+D + G + S + K+ +
Sbjct: 358 AAESSSD----------SSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPK 407
Query: 1037 EKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGR---EPASSIHDETLPGG 1093
+ + ++ KA + EE TK++ A + + + A S+ + P G
Sbjct: 408 QPVGGGQKLL--TRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQG 465
Query: 1094 SESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETE 1153
S ++ SD + E++ EE T+ S + +++ P S + ++ +N+ ++
Sbjct: 466 SRDSSSDSDSSSSEEE-EEKTSKSAVKKKPQKVAGGAAPSKPASAKKG-KAESSNSSSSD 523
Query: 1154 SPSQEFVNITKYESSLYSQ--EYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPS 1211
S+E K + S Q + + + +T NG + +K + ++ +A +S
Sbjct: 524 DSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNG--KAAKNSEEEEEEKKKAAVVVSKSG 581
Query: 1212 SMEEDKFSRSA 1222
S+++ K + +A
Sbjct: 582 SLKKRKQNEAA 592
Score = 69.3 bits (168), Expect = 4e-11
Identities = 109/524 (20%), Positives = 190/524 (36%), Gaps = 89/524 (16%)
Query: 595 KTETKPSVTEKEVPSKEE-----PSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDK 649
K + K S ++ E S+EE P KA V K+ KAA + + ++ +D
Sbjct: 77 KAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDD 136
Query: 650 KEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEV 709
EE +K K P++K KP+ + K KK + + E + PPK
Sbjct: 137 DEEDQK----------KQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSE---DEPPKNQ 183
Query: 710 KKEVKKEEKKEVKKEEKEPKKEIKKLPK------------DAKKSSTPLSEAKKPAAL-K 756
K ++ VK + K P K + PK + SS+ SE +K AA K
Sbjct: 184 KPKI---TPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK 240
Query: 757 PKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAA 816
VPKK+ K AA P K + E ++
Sbjct: 241 KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKN---------KPGPYSS 291
Query: 817 IGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAY 876
+ P ++SL + P + K + V+ ++D + + +EEK T+ V +
Sbjct: 292 VPPPSAPPPKKSLGTQPPKKAVE----KQQPVESSEDSSDESDSSSEEEKKPPTKAVVSK 347
Query: 877 VIQKEREVTKGPAESPDEGITTTEGEGECEQTP-----------------EELEP--VEK 917
K K S D + + + E P ++P K
Sbjct: 348 ATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPK 407
Query: 918 QGVDDIEKF---EDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCV---------- 964
Q V +K + + + EE S + + E+ + +P+ + + +
Sbjct: 408 QPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSR 467
Query: 965 -SASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQS------E 1017
S+S + EE + + + +++K + VA G A + +KG+AE S +
Sbjct: 468 DSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGG---AAPSKPASAKKGKAESSNSSSSDD 524
Query: 1018 EEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQ 1061
+EE+K + + K + A KAA+ EE+
Sbjct: 525 SSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEE 568
Score = 58.2 bits (139), Expect = 1e-07
Identities = 127/631 (20%), Positives = 250/631 (39%), Gaps = 81/631 (12%)
Query: 943 EEKAETEEAEEPEEDGEEHVCVSASKHS-PTEDEESAKAEADAYIREKRESVASGDDRAE 1001
++KA + ++E+ E+ EE A K + P + +A A E S S DD E
Sbjct: 79 KKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDE 138
Query: 1002 EDMD-EAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEE 1060
ED + ++KG Q A+ + P+K ++ D + D ++E +
Sbjct: 139 EDQKKQPVQKGVKPQ-------------AKAAKAPPKKAKSSD---SDSDSSSEDEPPKN 182
Query: 1061 QYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYT 1120
Q +T T + ++P + ++ S S +++S + + + E+ AT T
Sbjct: 183 QKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKT 242
Query: 1121 QSTIEISSEPTPMDEMSTP--RDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPA 1178
++ ++ P+ +TP + S++++++E E + N SS+ S P
Sbjct: 243 VPKKQVVAK-APVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPP--SAPP 299
Query: 1179 DVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVK-----A 1233
L + + + +S S SS EE K A+ ++ A
Sbjct: 300 PKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAA 359
Query: 1234 STTLDIKDSISAVSSEKVS-PSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEA 1292
++ D DS S+ E S P+ + S + P+ K+P +V + P + +
Sbjct: 360 ESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSP----AVKPAAAPKQPVGGGQK 415
Query: 1293 EVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQ--SVTGSAGHTPYYQSPTDEKSSHLPT 1350
+ + + E EE +S E+KT ++V+ ++ + +A P Q+P + S +
Sbjct: 416 LLTRKADSSSSE--EESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDS 473
Query: 1351 EVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAY 1410
+ S +++E E+ S S + + P + S P +
Sbjct: 474 DS-------------SSSEEEEEKTSKSAV------KKKPQKVAGGAAPSKPASAKKGKA 514
Query: 1411 ESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKE 1470
ES + +S + EEK +GSP +P + TS Q+ + K+++ E
Sbjct: 515 ES----SNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSE-----E 565
Query: 1471 DFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKS 1530
+ ++KK V + S +L +RK + + + + Q K T + + +K
Sbjct: 566 EEEEKKKAAVVVSKSG----SLKKRKQNEAA-KEAETPQAKKIKLQTPNTFPKRKKGEKR 620
Query: 1531 AT-----------PVDEGVAEDTYSHMEGVA 1550
A+ VD VA++++ G A
Sbjct: 621 ASSPFRRVREEEIEVDSRVADNSFDAKRGAA 651
Score = 57.0 bits (136), Expect = 2e-07
Identities = 63/271 (23%), Positives = 109/271 (40%), Gaps = 12/271 (4%)
Query: 2069 EKKSPSEARQDV-DLCLVSSCEYKHPKTE--LSPSFINPNPLEWFASEEPTEESEKPLTQ 2125
EK+ P E+ +D D SS E K P T+ +S + P P + A+E ++ S+ ++
Sbjct: 314 EKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKK-AAESSSDSSDSDSSE 372
Query: 2126 SGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESE 2185
AP P G + T P+ ++ + AD++ SE+ES
Sbjct: 373 DDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSS-SSEEESS 431
Query: 2186 TIPTDKTVTYKHMDPPPAPVQ-----DRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLK 2240
+ +KT P A + +P+ S D ++ + E+ K K +K
Sbjct: 432 SSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVK 491
Query: 2241 EKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAA 2300
+K + G + KK GK++ +S +E +K+ SP+ +
Sbjct: 492 KKPQKVAGGAAPSKPASAKK--GKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGT 549
Query: 2301 KPTTTPEVKAARGEEKDKETKNAANASASKS 2331
T KAA+ E+++E K A SKS
Sbjct: 550 SALTAQNGKAAKNSEEEEEEKKKAAVVVSKS 580
Score = 56.2 bits (134), Expect = 4e-07
Identities = 101/501 (20%), Positives = 176/501 (35%), Gaps = 40/501 (7%)
Query: 1416 ADDKASGRGAESPFEEKSGKQGSPDQVSPVSE----MTSTSLYQDKQEGKSTDFAPIKED 1471
A KAS +E EE+ QG P + + V + E S++ + +D
Sbjct: 78 AKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDD 137
Query: 1472 FGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSA 1531
+KK + + Q A K S + D S ++ K I+ TV ++
Sbjct: 138 EEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTK 197
Query: 1532 TPVDEGVAEDTYSHMEGVASVSTASVATSSFPEP------TTDDVSPSLHAEVGSPHSTE 1585
P A ++ + +S S++S ++SS T P +P
Sbjct: 198 APPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAA 257
Query: 1586 VDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSM 1645
+ S + ++ +E E + P P S PP +P KS ++ +
Sbjct: 258 TTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQ 317
Query: 1646 SIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGP--TEVDYSPSDMQDSSLSHKI 1703
+E ++S ++S D S + P A V T P + S SD DS S
Sbjct: 318 PVESSEDSSDES---DSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDD 374
Query: 1704 PPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQ--------------IASPLQEDT 1749
+P+ T N ++ ++ SP+ A P Q +S +E +
Sbjct: 375 EAPSKPAGTTKNSSNKPAVTTK---SPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESS 431
Query: 1750 LSDVAPPRDM--SLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPTFSDSTSAV 1807
S+ + M + T++ SL K +P+ + +SS S SAV
Sbjct: 432 SSEEEKTKKMVATTKPKATAKAALSLPA-KQAPQGSRDSSSDSDSSSSEEEEEKTSKSAV 490
Query: 1808 KEKTATCHSSSSP--PIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGKTP 1865
K+K ++P P A + +S D+ + L G + K
Sbjct: 491 KKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEE---EEKLKGKGSPRPQAPKAN 547
Query: 1866 GDFSYAYQKPEETTRSPDEED 1886
G + Q + S +EE+
Sbjct: 548 GTSALTAQNGKAAKNSEEEEE 568
Score = 41.6 bits (96), Expect = 0.010
Identities = 64/294 (21%), Positives = 100/294 (34%), Gaps = 61/294 (20%)
Query: 2071 KSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAP 2130
K+P + + D SS E + PK + I P ++ P P +G A
Sbjct: 158 KAPPKKAKSSDSDSDSSSEDEPPKNQKPK--ITPVTVKAQTKAPPKPARAAPKIANGKAA 215
Query: 2131 PPPGGKQQGRQCDE--------TPPTSVSESAPSQTDSDVPPETEECP----SITADANI 2178
D+ TP +V + Q + P + P S + D++
Sbjct: 216 SSSSSSSSSSSSDDSEEEKAAATPKKTVPKK---QVVAKAPVKAATTPTRKSSSSEDSSS 272
Query: 2179 DSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKD 2238
D E+E + +K Y + PP AP +S + P KA++K
Sbjct: 273 DEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPK----------------KAVEKQ 316
Query: 2239 LKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEK 2298
++ SS KK K+ A+ KP K++++ S + E E
Sbjct: 317 QPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEA 376
Query: 2299 AAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVPP 2352
+KP T TKN++N A TTKS AV P
Sbjct: 377 PSKPAGT--------------TKNSSNKPA--------------VTTKSPAVKP 402
Score = 35.8 bits (81), Expect = 0.54
Identities = 49/216 (22%), Positives = 79/216 (36%), Gaps = 20/216 (9%)
Query: 2233 KALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASP-- 2290
KA KK ++ + P KK+ +K + P A K S S +S
Sbjct: 77 KAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDD 136
Query: 2291 ----KKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTK-TT 2345
+KK+ V+K KP + KAA+ K ++ ++ + S+S+ P T T
Sbjct: 137 DEEDQKKQPVQKGVKP----QAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTV 192
Query: 2346 KSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGNDPAAEEPSRAVLDAL 2405
K+ P P P +N K SS S + AA P + V
Sbjct: 193 KAQTKAPPKPARA----APKIANGKAAS-SSSSSSSSSSSDDSEEEKAAATPKKTVPKKQ 247
Query: 2406 LEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQ 2441
+ KA ++ PT S + + E+Q+
Sbjct: 248 VVAKAP----VKAATTPTRKSSSSEDSSSDEEEEQK 279
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 86.3 bits (212), Expect = 3e-16
Identities = 63/220 (28%), Positives = 115/220 (52%), Gaps = 12/220 (5%)
Query: 533 TKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDK 592
T+L+ + S S + K R+E ++ E K E+ K + K K K+++
Sbjct: 15 TELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRK---KRER 71
Query: 593 PIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEE 652
+ E K EK+ + E K + EK+ + K + +E+ KKE K + + K+
Sbjct: 72 GKERERKRKEREKQRKERREKERRKRK-KEKKKRERKQRGRRERKKKKERKERERENKQR 130
Query: 653 KEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKE 712
+E+ +K+ KK+ + KE K +KE K+E K++ +K+E++E K+E + KE KKE
Sbjct: 131 RERKRKKRRKKKRR----KERKREKERGKRERKRKKRKKEEREKKRERNR----KERKKE 182
Query: 713 VKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKP 752
+++E++E KKE K+ +++ K+ KD K S+ +P
Sbjct: 183 RERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRP 222
Score = 78.2 bits (191), Expect = 9e-14
Identities = 51/204 (25%), Positives = 103/204 (50%), Gaps = 14/204 (6%)
Query: 567 EVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQAT 626
++ +H+ KP E+ ++++ + + ++E KE+ K E ++
Sbjct: 18 QMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKE--- 74
Query: 627 DVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKK 686
+E+ K+ K + E +++E+ K KKE K+E K ++E K KKE ++E +
Sbjct: 75 -------RERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKEREREN 127
Query: 687 EIKKEEKKEPKKEVKKETPPKEVKKEVKKEEK-KEVKKEEKEPKKEIKKLPKDAKKSSTP 745
+ ++E K++ +++ K+ K K+ K+E K K+ KKEE+E K+E + + ++
Sbjct: 128 KQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKE 187
Query: 746 LSEAKKPAALKPKVPKKEESVKKD 769
E KK + K +K++ KKD
Sbjct: 188 RRERKKE---RKKERRKKKERKKD 208
Score = 75.1 bits (183), Expect = 8e-13
Identities = 58/197 (29%), Positives = 101/197 (51%), Gaps = 16/197 (8%)
Query: 598 TKPSVTEKEVPSKEEPSPVKAE-VAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKP 656
+KP + KE K + EK+ + K K+K K+E + E K++E+EK
Sbjct: 26 SKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQ 85
Query: 657 KKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETP---PKEVKKEV 713
+KE +KE + +K+EK K+E ++ ++ KK+E+KE ++E K+ K KK+
Sbjct: 86 RKERREKERRK--RKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKR 143
Query: 714 KKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAA 773
+KE K+E ++ ++E K++ +K + KK E KK K + +K+E
Sbjct: 144 RKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKE--------- 194
Query: 774 GKPKEKGKIKVIKKEGK 790
+ KE+ K K KK+ K
Sbjct: 195 -RKKERRKKKERKKDRK 210
Score = 72.4 bits (176), Expect = 5e-12
Identities = 49/165 (29%), Positives = 88/165 (53%), Gaps = 4/165 (2%)
Query: 629 KPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEI 688
KP +E KKE + + E +K E+EK +K K++K KK E+ K+ E K++ +++
Sbjct: 27 KPCTQRESERKKERRER-EKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQ 85
Query: 689 KKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSE 748
+KE +++ +++ KKE +E K+ ++E KK KKE KE ++E K ++ K+ +
Sbjct: 86 RKERREKERRKRKKEKKKRERKQRGRRERKK--KKERKERERE-NKQRRERKRKKRRKKK 142
Query: 749 AKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAE 793
+K + + K+E KK + K + K KKE + E
Sbjct: 143 RRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKE 187
Score = 65.9 bits (159), Expect = 5e-10
Identities = 59/205 (28%), Positives = 94/205 (45%), Gaps = 22/205 (10%)
Query: 536 KQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIK 595
++R RE + + K RK+ + K EK K E +EK K+ K K
Sbjct: 44 EKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRK-ERREKERRKRKKEKK 102
Query: 596 TETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPE-DKKEEKE 654
+ +E K+E + E KQ + K K ++K +KE K + E K+E K
Sbjct: 103 KRERKQRGRRERKKKKERKERERE--NKQRRERKRKKRRKKKRRKERKREKERGKRERKR 160
Query: 655 KPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVK 714
K +K K+E + K+E +KE KKE +++E++E KKE KKE + K
Sbjct: 161 KKRK-----------KEEREKKRERNRKERKKERERKERRERKKERKKE-------RRKK 202
Query: 715 KEEKKEVKKEEKEPKKEIKKLPKDA 739
KE KK+ K + + + + L + A
Sbjct: 203 KERKKDRKTDRQTDSQVFRPLRESA 227
Score = 52.0 bits (123), Expect = 7e-06
Identities = 42/172 (24%), Positives = 81/172 (47%), Gaps = 9/172 (5%)
Query: 531 KQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKK 590
K+ + K+R R + + + +E K + E + EK + KEK ++
Sbjct: 47 KREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRER 106
Query: 591 DKPIKTETKPSVTEKEVPSKEEPSPV---KAEVAEKQATDVKPKAAKEKTVKKETKVKPE 647
+ + E K KE + + K +K+ + K + + K +K K K E
Sbjct: 107 KQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKE 166
Query: 648 DKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKE 699
++++++E+ +KE K+ + +KE + +K+E KKE +K KKE KK+ K +
Sbjct: 167 EREKKRERNRKERKKERE----RKERRERKKERKKERRK--KKERKKDRKTD 212
Score = 49.7 bits (117), Expect = 4e-05
Identities = 40/165 (24%), Positives = 74/165 (44%), Gaps = 12/165 (7%)
Query: 531 KQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKK 590
K+ K ++R RE K + RKE +E K K K + + K ++
Sbjct: 64 KKRKKRERGKERER-----KRKEREKQRKERRE------KERRKRKKEKKKRERKQRGRR 112
Query: 591 DKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKK 650
++ K E K E + + + + + K+ K + +E+ KK K + E K+
Sbjct: 113 ERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKR 172
Query: 651 EEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKE 695
E K +K+ +++++ KKE K K+ KKE KK+ K + + +
Sbjct: 173 ERNRKERKKERERKERRERKKERK-KERRKKKERKKDRKTDRQTD 216
Score = 49.3 bits (116), Expect = 5e-05
Identities = 40/159 (25%), Positives = 66/159 (41%), Gaps = 8/159 (5%)
Query: 531 KQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVN-HVEKPPKVESKEKVMVK 589
K+ + K+R R+ + K K RK KE+ K E+ K E KE+
Sbjct: 68 KRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKEREREN 127
Query: 590 KDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDK 649
K + + K ++ K E K E K K KE+ KK + + E K
Sbjct: 128 KQRRERKRKKRRKKKRRKERKREKERGKRERKRK-------KRKKEEREKKRERNRKERK 180
Query: 650 KEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEI 688
KE + K ++E K+ K KK+E+ K + ++ ++
Sbjct: 181 KERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQV 219
Score = 42.4 bits (98), Expect = 0.006
Identities = 37/155 (23%), Positives = 66/155 (42%), Gaps = 3/155 (1%)
Query: 531 KQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKK 590
++ + KQR + RE + K K RK+ + K + + +E+ K+
Sbjct: 79 RKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKR 138
Query: 591 DKPIKTETKPSVTEKEVPSKEEPSPV-KAEVAEKQATDVKPKAAKEKTVKKETKVKPEDK 649
K K K EKE +E K E EK+ + + KE+ K+ + K E K
Sbjct: 139 RK--KKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERK 196
Query: 650 KEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEV 684
KE ++K +++ +K D+ + +P +E V
Sbjct: 197 KERRKKKERKKDRKTDRQTDSQVFRPLRESAFNRV 231
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.303 0.123 0.336
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 107,307,823
Number of Sequences: 37866
Number of extensions: 5943103
Number of successful extensions: 92920
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 882
Number of HSP's successfully gapped in prelim test: 2013
Number of HSP's that attempted gapping in prelim test: 24776
Number of HSP's gapped (non-prelim): 26687
length of query: 2468
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2349
effective length of database: 13,741,464
effective search space: 32278698936
effective search space used: 32278698936
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.