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Search of human proteins with 153070264
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153070264 meprin A beta [Homo sapiens]
(701 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153070264 meprin A beta [Homo sapiens] 1452 0.0
gi|153070262 meprin A alpha [Homo sapiens] 514 e-145
gi|157502169 astacin-like metalloendopeptidase [Homo sapiens] 140 5e-33
gi|6912724 tolloid-like 2 [Homo sapiens] 126 8e-29
gi|22547221 tolloid-like 1 [Homo sapiens] 125 2e-28
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom... 125 2e-28
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom... 125 2e-28
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom... 125 2e-28
gi|24111244 MAM domain containing glycosylphosphatidylinositol a... 76 1e-13
gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens] 65 2e-10
gi|38158013 MAM domain containing 1 isoform 2 [Homo sapiens] 65 2e-10
gi|22027622 TNF receptor-associated factor 4 [Homo sapiens] 59 2e-08
gi|223278413 MAM domain containing 2 [Homo sapiens] 57 4e-08
gi|223942069 enterokinase precursor [Homo sapiens] 54 5e-07
gi|182508169 neuropilin 1 isoform a [Homo sapiens] 53 8e-07
gi|57242793 interphotoreceptor matrix proteoglycan 2 [Homo sapiens] 53 1e-06
gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Ho... 49 1e-05
gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Ho... 49 1e-05
gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Ho... 49 1e-05
gi|119220585 apical early endosomal glycoprotein precursor [Homo... 48 4e-05
gi|16554449 zonadhesin isoform 3 [Homo sapiens] 45 2e-04
gi|27881494 zonadhesin isoform 6 [Homo sapiens] 45 2e-04
gi|22027612 TNF receptor-associated factor 2 [Homo sapiens] 45 3e-04
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens] 43 0.001
gi|22027616 TNF receptor-associated factor 3 isoform 1 [Homo sap... 42 0.001
gi|22027620 TNF receptor-associated factor 3 isoform 2 [Homo sap... 42 0.001
gi|22027618 TNF receptor-associated factor 3 isoform 1 [Homo sap... 42 0.001
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 40 0.006
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens] 40 0.006
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 40 0.006
>gi|153070264 meprin A beta [Homo sapiens]
Length = 701
Score = 1452 bits (3760), Expect = 0.0
Identities = 701/701 (100%), Positives = 701/701 (100%)
Query: 1 MDLWNLSWFLFLDALLVISGLATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQI 60
MDLWNLSWFLFLDALLVISGLATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQI
Sbjct: 1 MDLWNLSWFLFLDALLVISGLATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQI 60
Query: 61 RNSIIGEKYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISVFK 120
RNSIIGEKYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISVFK
Sbjct: 61 RNSIIGEKYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISVFK 120
Query: 121 GSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRI 180
GSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRI
Sbjct: 121 GSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRI 180
Query: 181 LSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMD 240
LSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMD
Sbjct: 181 LSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMD 240
Query: 241 FSDSDLLKLNQLYNCSSSLSFMDSCSFELENVCGMIQSSGDNADWQRVSQVPRGPESDHS 300
FSDSDLLKLNQLYNCSSSLSFMDSCSFELENVCGMIQSSGDNADWQRVSQVPRGPESDHS
Sbjct: 241 FSDSDLLKLNQLYNCSSSLSFMDSCSFELENVCGMIQSSGDNADWQRVSQVPRGPESDHS 300
Query: 301 NMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIR 360
NMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIR
Sbjct: 301 NMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIR 360
Query: 361 EYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDI 420
EYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDI
Sbjct: 361 EYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDI 420
Query: 421 NLSETRCPHHIWHIRNFTQFIGSPNGTLYSPPFYSSKGYAFQIYLNLAHVTNAGIYFHLI 480
NLSETRCPHHIWHIRNFTQFIGSPNGTLYSPPFYSSKGYAFQIYLNLAHVTNAGIYFHLI
Sbjct: 421 NLSETRCPHHIWHIRNFTQFIGSPNGTLYSPPFYSSKGYAFQIYLNLAHVTNAGIYFHLI 480
Query: 481 SGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVG 540
SGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVG
Sbjct: 481 SGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVG 540
Query: 541 TVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSTQIQLTP 600
TVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSTQIQLTP
Sbjct: 541 TVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSTQIQLTP 600
Query: 601 APSVQDLCSKTTCKNDGVCTVRDGKAECRCQSGEDWWYMGERCEKRGSTRDTIVIAVSST 660
APSVQDLCSKTTCKNDGVCTVRDGKAECRCQSGEDWWYMGERCEKRGSTRDTIVIAVSST
Sbjct: 601 APSVQDLCSKTTCKNDGVCTVRDGKAECRCQSGEDWWYMGERCEKRGSTRDTIVIAVSST 660
Query: 661 VAVFALMLIITLVSVYCTRKKYRERMSSNRPNLTPQNQHAF 701
VAVFALMLIITLVSVYCTRKKYRERMSSNRPNLTPQNQHAF
Sbjct: 661 VAVFALMLIITLVSVYCTRKKYRERMSSNRPNLTPQNQHAF 701
>gi|153070262 meprin A alpha [Homo sapiens]
Length = 746
Score = 514 bits (1324), Expect = e-145
Identities = 266/578 (46%), Positives = 367/578 (63%), Gaps = 16/578 (2%)
Query: 28 DVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQIRNSIIGEKYRWPHTIPYVLEDSLEMNA 87
D D G +DI +IN GLDLF+GDI L ++ RN + RW IPY+L D+L +NA
Sbjct: 34 DADFGEQKDISEINLAAGLDLFQGDILLQKS--RNGLRDPNTRWTFPIPYILADNLGLNA 91
Query: 88 KGVILNAFERYRLKTCIDFKPWAGETNYISVFKGSGCWSSVGNRRVGKQELSIGANCDRI 147
KG IL AFE +RLK+C+DFKP+ GE++YI + GCWS VG++ VG Q +SIG C
Sbjct: 92 KGAILYAFEMFRLKSCVDFKPYEGESSYIIFQQFDGCWSEVGDQHVG-QNISIGQGCAYK 150
Query: 148 ATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHNFNTYSDDISDSLNVPYDYTS 207
A ++HE LHALGF+HEQSR+DRDDYV I WD+ILSG +HNF+TY D + LN PYDY S
Sbjct: 151 AIIEHEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYES 210
Query: 208 VMHYSKTAF-QNGTEPTIVTRISDFEDVIGQRMDFSDSDLLKLNQLYNCSSSLSFMDSCS 266
+MHY +F +N + PTI +I +F +IGQR+DFS DL +LN++YNC+++ + +D C+
Sbjct: 211 LMHYQPFSFNKNASVPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNCTTTHTLLDHCT 270
Query: 267 FELENVCGMIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFFMHFDSSSVNVGATAV 326
FE N+CGMIQ + D+ DW G E DH+ +GQC G+G+FM F +SS + A+
Sbjct: 271 FEKANICGMIQGTRDDTDWAHQDSAQAG-EVDHTLLGQCTGAGYFMQFSTSSGSAEEAAL 329
Query: 327 LESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIREYSADNVDGNLTLVEEIKEIPTGSWQ 386
LESR LYPKR QCLQF+ +GS SD+L +++R + L V+ + +W+
Sbjct: 330 LESRILYPKRKQQCLQFFYKMTGSPSDRLVVWVRRDDSTGNVRKLVKVQTFQGDDDHNWK 389
Query: 387 LYHVTLKVTKKFRVVFEGRKGSGA-SLGGLSIDDINLSETRCPHHIWHIRNFTQFI--GS 443
+ HV LK +KFR +F+G KG S GG+ +DDI L+ET CP +W +RNF+Q + S
Sbjct: 390 IAHVVLKEEQKFRYLFQGTKGDPQNSTGGIYLDDITLTETPCPTGVWTVRNFSQVLENTS 449
Query: 444 PNGTLYSPPFYSSKGYAFQIYLNLAHVTNAG---IYFHLISGANDDQLQWPCPWQQATMT 500
L SP FY+S+GY F + L ++G + FH+ SG ND L+WP +Q +T
Sbjct: 450 KGDKLQSPRFYNSEGYGFGVTLYPNSRESSGYLRLAFHVCSGENDAILEWPVENRQVIIT 509
Query: 501 LLDQNPDIRQRMSNQRSITTDPFMTTD--NGNYFWDRPSKVGTVALFSNGTQFRRGGGYG 558
+LDQ PD+R RMS+ TT T+ N WDRPS+VGT + R G
Sbjct: 510 ILDQEPDVRNRMSSSMVFTTSKSHTSPAINDTVIWDRPSRVGT---YHTDCNCFRSIDLG 566
Query: 559 TSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSTQI 596
S FI+H+ LK R F+K DD+ I + EDI+HL+ T++
Sbjct: 567 WSGFISHQMLKRRSFLKNDDLIIFVDFEDITHLSQTEV 604
>gi|157502169 astacin-like metalloendopeptidase [Homo sapiens]
Length = 431
Score = 140 bits (352), Expect = 5e-33
Identities = 94/251 (37%), Positives = 131/251 (52%), Gaps = 24/251 (9%)
Query: 23 TPENFDVDGGMDQDIFDINEGLGLD-------LFEGDIRLDRAQIRNSIIGEKYRWPH-- 73
TPE G D+DI IN+GL L+ L EGDI R + +WP
Sbjct: 43 TPEGTQASG--DKDIPAINQGLILEETPESSFLIEGDII--RPSPFRLLSATSNKWPMGG 98
Query: 74 ----TIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISVFKGSGCWSSVG 129
+P++L + ++ VIL A + TCI F + + ++IS+ GC+SSVG
Sbjct: 99 SGVVEVPFLLSSKYDEPSRQVILEALAEFERSTCIRFVTYQDQRDFISIIPMYGCFSSVG 158
Query: 130 NRRVGKQELSIGANCDRIAT--VQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHN 187
R G Q +S+ C + V HE +H LGFWHE +R+DRD Y+R+ W+ IL G E N
Sbjct: 159 -RSGGMQVVSLAPTCLQKGRGIVLHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEIN 217
Query: 188 FNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMDFSDSDLL 247
F S ++ PYDY+SVMHY + AF PTI T + IGQR + S SD+
Sbjct: 218 F---IKSQSSNMLTPYDYSSVMHYGRLAFSRRGLPTI-TPLWAPSVHIGQRWNLSASDIT 273
Query: 248 KLNQLYNCSSS 258
++ +LY CS S
Sbjct: 274 RVLKLYGCSPS 284
>gi|6912724 tolloid-like 2 [Homo sapiens]
Length = 1015
Score = 126 bits (316), Expect = 8e-29
Identities = 73/215 (33%), Positives = 106/215 (49%), Gaps = 12/215 (5%)
Query: 71 WPH-TIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISV-FKGSGCWSSV 128
WP IPYV+ + + + + A + TC+ F E ++I ++ GC S V
Sbjct: 159 WPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYV 218
Query: 129 GNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHNF 188
G R G Q +SIG NCD+ V HE H +GFWHE +R DRD +V I+ + I G+E+NF
Sbjct: 219 GRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNF 278
Query: 189 NTYSDDISDSLNVPYDYTSVMHYSKTAFQNGT-EPTIVTRISD--FEDVIGQRMDFSDSD 245
SL YD+ S+MHY++ F G TI+ R D IGQR+ S D
Sbjct: 279 LKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGD 338
Query: 246 LLKLNQLYNCSSSLSFMDSCSFELENVCGMIQSSG 280
+ + +LY C +C L++ G + G
Sbjct: 339 IAQARKLYKC-------PACGETLQDTTGNFSAPG 366
>gi|22547221 tolloid-like 1 [Homo sapiens]
Length = 1013
Score = 125 bits (313), Expect = 2e-28
Identities = 74/215 (34%), Positives = 107/215 (49%), Gaps = 12/215 (5%)
Query: 71 WPH-TIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYIS-VFKGSGCWSSV 128
WP IPYV+ + + + + A + TC+ F + E +YI ++ GC S V
Sbjct: 157 WPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIERSDEESYIVFTYRPCGCCSYV 216
Query: 129 GNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHNF 188
G R G Q +SIG NCD+ V HE H +GFWHE +R DRD++V I+ + I G+E+NF
Sbjct: 217 GRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNF 276
Query: 189 NTYSDDISDSLNVPYDYTSVMHYSKTAFQNGT-EPTIVTRISD--FEDVIGQRMDFSDSD 245
+SL YD+ S+MHY++ F G TI+ D IGQR S D
Sbjct: 277 LKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGD 336
Query: 246 LLKLNQLYNCSSSLSFMDSCSFELENVCGMIQSSG 280
+ + +LY C +C L+ G + S G
Sbjct: 337 IAQARKLYRC-------PACGETLQESNGNLSSPG 364
>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
sapiens]
Length = 730
Score = 125 bits (313), Expect = 2e-28
Identities = 69/190 (36%), Positives = 100/190 (52%), Gaps = 5/190 (2%)
Query: 71 WPH-TIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYIS-VFKGSGCWSSV 128
WP IP+V+ + + + V A + TC+ F E +YI ++ GC S V
Sbjct: 130 WPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYV 189
Query: 129 GNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHNF 188
G R G Q +SIG NCD+ V HE H +GFWHE +R DRD +V I+ + I G+E+NF
Sbjct: 190 GRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNF 249
Query: 189 NTYSDDISDSLNVPYDYTSVMHYSKTAFQNGT-EPTIVTR--ISDFEDVIGQRMDFSDSD 245
+SL YD+ S+MHY++ F G TIV + ++ + IGQR S D
Sbjct: 250 LKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGD 309
Query: 246 LLKLNQLYNC 255
+ + +LY C
Sbjct: 310 IAQARKLYKC 319
>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
sapiens]
Length = 823
Score = 125 bits (313), Expect = 2e-28
Identities = 69/190 (36%), Positives = 100/190 (52%), Gaps = 5/190 (2%)
Query: 71 WPH-TIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYIS-VFKGSGCWSSV 128
WP IP+V+ + + + V A + TC+ F E +YI ++ GC S V
Sbjct: 130 WPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYV 189
Query: 129 GNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHNF 188
G R G Q +SIG NCD+ V HE H +GFWHE +R DRD +V I+ + I G+E+NF
Sbjct: 190 GRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNF 249
Query: 189 NTYSDDISDSLNVPYDYTSVMHYSKTAFQNGT-EPTIVTR--ISDFEDVIGQRMDFSDSD 245
+SL YD+ S+MHY++ F G TIV + ++ + IGQR S D
Sbjct: 250 LKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGD 309
Query: 246 LLKLNQLYNC 255
+ + +LY C
Sbjct: 310 IAQARKLYKC 319
>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
sapiens]
Length = 986
Score = 125 bits (313), Expect = 2e-28
Identities = 69/190 (36%), Positives = 100/190 (52%), Gaps = 5/190 (2%)
Query: 71 WPH-TIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYIS-VFKGSGCWSSV 128
WP IP+V+ + + + V A + TC+ F E +YI ++ GC S V
Sbjct: 130 WPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYV 189
Query: 129 GNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHNF 188
G R G Q +SIG NCD+ V HE H +GFWHE +R DRD +V I+ + I G+E+NF
Sbjct: 190 GRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNF 249
Query: 189 NTYSDDISDSLNVPYDYTSVMHYSKTAFQNGT-EPTIVTR--ISDFEDVIGQRMDFSDSD 245
+SL YD+ S+MHY++ F G TIV + ++ + IGQR S D
Sbjct: 250 LKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGD 309
Query: 246 LLKLNQLYNC 255
+ + +LY C
Sbjct: 310 IAQARKLYKC 319
>gi|24111244 MAM domain containing glycosylphosphatidylinositol
anchor 1 [Homo sapiens]
Length = 955
Score = 75.9 bits (185), Expect = 1e-13
Identities = 52/175 (29%), Positives = 83/175 (47%), Gaps = 17/175 (9%)
Query: 263 DSCSFELENVCGMIQSSGDNADWQR---VSQVPR-----GPESDHSNMGQCQGSGFFMHF 314
++C FE E +CG Q DN DW R ++Q P+ GP +D S + G++M
Sbjct: 751 NTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPE----GYYMFI 806
Query: 315 DSSSV-NVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIREYSADNVDGNLTL 373
++S +G A L S F C+ F+ + G LN+ +R + +D T
Sbjct: 807 ETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALD---TH 863
Query: 374 VEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSETRCP 428
+ WQ HV + + F+++FEG +G G LG ++IDD+ L + CP
Sbjct: 864 AWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPG-YLGDIAIDDVTLKKGECP 917
>gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens]
Length = 956
Score = 65.5 bits (158), Expect = 2e-10
Identities = 50/180 (27%), Positives = 79/180 (43%), Gaps = 25/180 (13%)
Query: 265 CSFELENVCGMIQSSGDNADWQRVSQVPR--------GPESDHSNMGQCQGSGFFMHFDS 316
C FE N+C Q DN DW + S R GP +D S + GF+M+ ++
Sbjct: 748 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKE----GFYMYIET 803
Query: 317 SSVNV-GATAVLESR--TLYPKRGF------QCLQFYLYNSGSESDQLNIYIREYSADNV 367
S + G A L S ++ PK + C F+ + G LN+Y+R +
Sbjct: 804 SRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTI 863
Query: 368 DGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSETRC 427
+ L K W HV + F+++FEG +G G G ++IDD++++E C
Sbjct: 864 ENPLWSSSGNK---GQRWNEAHVNIYPITSFQLIFEGIRGPGIE-GDIAIDDVSIAEGEC 919
>gi|38158013 MAM domain containing 1 isoform 2 [Homo sapiens]
Length = 727
Score = 65.5 bits (158), Expect = 2e-10
Identities = 50/180 (27%), Positives = 79/180 (43%), Gaps = 25/180 (13%)
Query: 265 CSFELENVCGMIQSSGDNADWQRVSQVPR--------GPESDHSNMGQCQGSGFFMHFDS 316
C FE N+C Q DN DW + S R GP +D S + GF+M+ ++
Sbjct: 519 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKE----GFYMYIET 574
Query: 317 SSVNV-GATAVLESR--TLYPKRGF------QCLQFYLYNSGSESDQLNIYIREYSADNV 367
S + G A L S ++ PK + C F+ + G LN+Y+R +
Sbjct: 575 SRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTI 634
Query: 368 DGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSETRC 427
+ L K W HV + F+++FEG +G G G ++IDD++++E C
Sbjct: 635 ENPLWSSSGNK---GQRWNEAHVNIYPITSFQLIFEGIRGPGIE-GDIAIDDVSIAEGEC 690
>gi|22027622 TNF receptor-associated factor 4 [Homo sapiens]
Length = 470
Score = 58.5 bits (140), Expect = 2e-08
Identities = 48/167 (28%), Positives = 77/167 (46%), Gaps = 25/167 (14%)
Query: 431 IWHI----RNFTQFIGSPNGTLYSPPFYSSK-GYAFQI--YLN---LAHVTNAGIYFHLI 480
IW I R + PN +SP FY+ K GY Q+ +LN T+ +Y ++
Sbjct: 311 IWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVL 370
Query: 481 SGANDDQLQWPCPWQQATMTLLDQN-PDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKV 539
GA D+ L+WP ++ T +LLDQ+ P + + + DP W K
Sbjct: 371 PGAFDNLLEWPFA-RRVTFSLLDQSDPGLAKPQHVTETFHPDPN---------WKNFQKP 420
Query: 540 GTVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVE 586
GT G+ G+G FI+H+ ++ R++++ D V+I VE
Sbjct: 421 GTW----RGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVE 463
>gi|223278413 MAM domain containing 2 [Homo sapiens]
Length = 686
Score = 57.4 bits (137), Expect = 4e-08
Identities = 50/198 (25%), Positives = 90/198 (45%), Gaps = 22/198 (11%)
Query: 241 FSDSDLLKLN----QLYNCSSSLSFMD---SCSFELENVCGMIQSSGDNADW-QRVSQVP 292
F D L+ L+ QL +CSSS C+FE ++ C Q + + W +R + P
Sbjct: 478 FWDCGLVALDDITIQLGSCSSSEKLPPPPGECTFE-QDECTFTQEKRNRSSWHRRRGETP 536
Query: 293 R---GPESDHSNMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSG 349
GP+ DH+ G G++M+ ++S + G A L SR L G CL F+ + G
Sbjct: 537 TSYTGPKGDHTT-----GVGYYMYIEASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYG 591
Query: 350 SESDQLNIYIREYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSG 409
+ L++Y+++ D +L+ + + SW + ++ +++FE +G
Sbjct: 592 GGTGLLSVYLKK----EEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVS 647
Query: 410 ASLGGLSIDDINLSETRC 427
++IDD+ C
Sbjct: 648 IR-SDIAIDDVKFQAGPC 664
Score = 43.1 bits (100), Expect = 9e-04
Identities = 44/189 (23%), Positives = 70/189 (37%), Gaps = 31/189 (16%)
Query: 252 LYNCSSSLSFMDSCSFELENVCGMIQSSGDNADW----QRVSQVPRGPESDHSNMGQCQG 307
L+ + + C FE ++CG + N +W + V DH+ +
Sbjct: 157 LFEIKMTTGYCIECDFEENHLCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSEL-- 214
Query: 308 SGFFMHFDSSSVN--VGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIREYSAD 365
G +M+ DS V ++ T P G CL FY + ++Y R+ +
Sbjct: 215 -GHYMYVDSVYVKHFQEVAQLISPLTTAPMAG--CLSFYYQIQQGNDNVFSLYTRDVAG- 270
Query: 366 NVDGNLTLVEEIKEIP---TGSWQLYHVTLKVTKKFRVVFE----GRKGSGASLGGLSID 418
L EEI + +W L V V+FE G KG G +++D
Sbjct: 271 -------LYEEIWKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKG-----GYVALD 318
Query: 419 DINLSETRC 427
DI+ S C
Sbjct: 319 DISFSPVHC 327
Score = 40.0 bits (92), Expect = 0.007
Identities = 36/125 (28%), Positives = 65/125 (52%), Gaps = 13/125 (10%)
Query: 309 GFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQF-YLYNSGSES----DQLNIYIREYS 363
G +++ D+S G AVL S L + + CL+ Y + SES QLN+Y+R +
Sbjct: 50 GHYIYVDTSFGKQGEKAVLLSPDLQAEE-WSCLRLVYQITTSSESLSDPSQLNLYMR-FE 107
Query: 364 ADNVDGNLTLVEEIKEIPTGSWQLYHVTLK-VTKKFRVVFEGRKGSGASLGGLSIDDINL 422
++ D L +E P+ SW + + L+ +KKF+++ EG G G + +++ +I +
Sbjct: 108 DESFDRLLWSAKE----PSDSWLIASLDLQNSSKKFKILIEGVLGQG-NTASIALFEIKM 162
Query: 423 SETRC 427
+ C
Sbjct: 163 TTGYC 167
Score = 36.2 bits (82), Expect = 0.11
Identities = 45/172 (26%), Positives = 73/172 (42%), Gaps = 24/172 (13%)
Query: 264 SCSFELENVCGMIQSSGDNADWQRVSQVPRGPES-DHSNMGQCQGSGFFMHFDSSSVNV- 321
SC+FE +++C Q + W RV P + DH+ G G+++ ++ +
Sbjct: 341 SCNFE-QDLCNFYQDK-EGPGWTRVKVKPNMYRAGDHTT-----GLGYYLLANTKFTSQP 393
Query: 322 GATAVLESRTLYPKRGFQCLQFY--LYNSGSESDQLNIYIREYSADNVDGNLTLVEE--- 376
G L +L P CL+F+ +Y SD L +YI E + +V+E
Sbjct: 394 GYIGRLYGPSL-PGNLQYCLRFHYAIYGFLKMSDTLAVYIFEENH--------VVQEKIW 444
Query: 377 -IKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSETRC 427
+ E P G W +T K +VVF S G +++DDI + C
Sbjct: 445 SVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLGSC 496
>gi|223942069 enterokinase precursor [Homo sapiens]
Length = 1019
Score = 53.9 bits (128), Expect = 5e-07
Identities = 70/275 (25%), Positives = 106/275 (38%), Gaps = 44/275 (16%)
Query: 187 NFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMDFSDSDL 246
+FNTY DI D Y+ + + TI RI + ++ +SD
Sbjct: 271 DFNTYYTDILDI----YEGVGSSKILRASIWETNPGTI--RIFSNQVTATFLIESDESDY 324
Query: 247 LKLNQLYNCSSSLSFMD----SCSFELENVCGMIQSSGDNADWQRVSQVP----RGPESD 298
+ N Y +S + +C+FE + C +Q D+ +W+R+ GP D
Sbjct: 325 VGFNATYTAFNSSELNNYEKINCNFE-DGFCFWVQDLNDDNEWERIQGSTFSPFTGPNFD 383
Query: 299 HSNMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIY 358
H+ G SGF++ + L S L P CL F+ + G +L+I
Sbjct: 384 HT-FGNA--SGFYISTPTGPGGRQERVGLLSLPLDPTLEPACLSFWYHMYGENVHKLSIN 440
Query: 359 IREYSADNVDGNLTLVEEIKEIPTG-SWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSI 417
I D N+ KE G +W VTL T KF+V F K L +++
Sbjct: 441 ISN------DQNMEKTVFQKEGNYGDNWNYGQVTLNETVKFKVAFNAFKNK--ILSDIAL 492
Query: 418 DDINLSETRCPHHIWHIRNFTQFIGSPNGTLYSPP 452
DDI+L+ C NG+LY P
Sbjct: 493 DDISLTYGIC-----------------NGSLYPEP 510
>gi|182508169 neuropilin 1 isoform a [Homo sapiens]
Length = 923
Score = 53.1 bits (126), Expect = 8e-07
Identities = 39/131 (29%), Positives = 62/131 (47%), Gaps = 11/131 (8%)
Query: 294 GPESDHSNMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESD 353
GP DH+ G G F++ + G A L S +Y + C+ F+ + SGS
Sbjct: 681 GPIQDHT------GDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVG 734
Query: 354 QLNIYIREYSADNVDGNLTLVEEIKEIPTGSWQLYHVTL-KVTKKFRVVFEGRKGSGASL 412
L + +R + D LV W+ V L K K ++V+FEG G G +L
Sbjct: 735 TLRVKLRYQKPEEYD---QLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKG-NL 790
Query: 413 GGLSIDDINLS 423
GG+++DDI+++
Sbjct: 791 GGIAVDDISIN 801
>gi|57242793 interphotoreceptor matrix proteoglycan 2 [Homo sapiens]
Length = 1241
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/76 (36%), Positives = 40/76 (52%), Gaps = 2/76 (2%)
Query: 596 IQLTPAPSVQDLCSKTTCKNDGVCTVRDGK-AECRCQSGEDWWYMGERCEKRGSTRDTIV 654
++ P S+ DL C NDG C + G A CRC+ GE+WWY G+ CE+ S I
Sbjct: 1045 VEERPCQSLCDL-QPDFCLNDGKCDIMPGHGAICRCRVGENWWYRGKHCEEFVSEPVIIG 1103
Query: 655 IAVSSTVAVFALMLII 670
I ++S V + + I
Sbjct: 1104 ITIASVVGLLVIFSAI 1119
>gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1542
Score = 49.3 bits (116), Expect = 1e-05
Identities = 48/181 (26%), Positives = 78/181 (43%), Gaps = 22/181 (12%)
Query: 254 NCSSSLSFMDSCSFELEN-----VCGMIQSSGDNADWQRVSQVPRG---PESDHSNMGQC 305
+C+ S SC+FE + C + Q S D+ DW S++P P+SDH+
Sbjct: 1153 HCAHYTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHT----- 1207
Query: 306 QGSG-FFMHFDSSSVNVGATAVLESRTLYP-KRGFQCLQFYLYNSGSES-DQLNIYIREY 362
GSG F++ +SS G+ A + + +P G ++F+ Y S L +Y E
Sbjct: 1208 PGSGQHFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEE 1267
Query: 363 SADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINL 422
S N+ LV + W V L F+V FE + +++DDI+
Sbjct: 1268 SGLNI-----LVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDI-FIALDDISF 1321
Query: 423 S 423
+
Sbjct: 1322 T 1322
Score = 41.6 bits (96), Expect = 0.003
Identities = 43/167 (25%), Positives = 76/167 (45%), Gaps = 19/167 (11%)
Query: 265 CSFELENVCGMIQSSGDNADWQ-RVSQVPRG---PESDHSNMGQCQGSGFFMHFDSSSVN 320
C FE + +C Q ++ DW + S +P P +DH+ +G SG ++ +S
Sbjct: 672 CDFEFD-LCSWKQEKDEDFDWNLKASSIPAAGTEPAADHT-LGN--SSGHYIFINSLFPQ 727
Query: 321 VGATAVLESRTLYPKRGFQC---LQFYLYNSGSESDQLNIYIREYSADNVDGNLTLVEEI 377
A S + KR C +++Y +G + L + + + V NLT+ +
Sbjct: 728 QPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGALTL-MQVSVTNQTKVLLNLTVEQG- 785
Query: 378 KEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSE 424
W+ ++L + F++ FEGR G G G +++DDI L+E
Sbjct: 786 -----NFWRREELSLFGDEDFQLKFEGRVGKG-QRGDIALDDIVLTE 826
Score = 37.0 bits (84), Expect = 0.062
Identities = 36/104 (34%), Positives = 48/104 (46%), Gaps = 16/104 (15%)
Query: 256 SSSLSFMDSCSFELENVCGMIQS-SGDNADWQRVSQVP-------RGPESDHS-NMGQCQ 306
SS ++ C FE N C ++ SGD+ DW R SQ + P DHS N Q
Sbjct: 10 SSMKIWVSKCDFEA-NSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQ-- 66
Query: 307 GSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQC-LQFYLYNSG 349
G FM S ++ A L+S T + + G C L F+ YN G
Sbjct: 67 --GHFMFILKKSSSLWQVAKLQSPT-FSQTGPGCILSFWFYNYG 107
>gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 49.3 bits (116), Expect = 1e-05
Identities = 48/181 (26%), Positives = 78/181 (43%), Gaps = 22/181 (12%)
Query: 254 NCSSSLSFMDSCSFELEN-----VCGMIQSSGDNADWQRVSQVPRG---PESDHSNMGQC 305
+C+ S SC+FE + C + Q S D+ DW S++P P+SDH+
Sbjct: 1428 HCAHYTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHT----- 1482
Query: 306 QGSG-FFMHFDSSSVNVGATAVLESRTLYP-KRGFQCLQFYLYNSGSES-DQLNIYIREY 362
GSG F++ +SS G+ A + + +P G ++F+ Y S L +Y E
Sbjct: 1483 PGSGQHFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEE 1542
Query: 363 SADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINL 422
S N+ LV + W V L F+V FE + +++DDI+
Sbjct: 1543 SGLNI-----LVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDI-FIALDDISF 1596
Query: 423 S 423
+
Sbjct: 1597 T 1597
Score = 40.8 bits (94), Expect = 0.004
Identities = 43/167 (25%), Positives = 75/167 (44%), Gaps = 19/167 (11%)
Query: 265 CSFELENVCGMIQSSGDNADWQ-RVSQVPRG---PESDHSNMGQCQGSGFFMHFDSSSVN 320
C FE + +C Q ++ DW + S +P P +DH+ +G SG ++ S
Sbjct: 947 CDFEFD-LCSWKQEKDEDFDWNLKASSIPAAGTEPAADHT-LGN--SSGHYIFIKSLFPQ 1002
Query: 321 VGATAVLESRTLYPKRGFQC---LQFYLYNSGSESDQLNIYIREYSADNVDGNLTLVEEI 377
A S + KR C +++Y +G + L + + + V NLT+ +
Sbjct: 1003 QPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGALTL-MQVSVTNQTKVLLNLTVEQG- 1060
Query: 378 KEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSE 424
W+ ++L + F++ FEGR G G G +++DDI L+E
Sbjct: 1061 -----NFWRREELSLFGDEDFQLKFEGRVGKG-QRGDIALDDIVLTE 1101
Score = 37.0 bits (84), Expect = 0.062
Identities = 36/104 (34%), Positives = 48/104 (46%), Gaps = 16/104 (15%)
Query: 256 SSSLSFMDSCSFELENVCGMIQS-SGDNADWQRVSQVP-------RGPESDHS-NMGQCQ 306
+S+ S C FE N C ++ SGD+ DW R SQ + P DHS N Q
Sbjct: 285 TSTQSKFSKCDFEA-NSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQ-- 341
Query: 307 GSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQC-LQFYLYNSG 349
G FM S ++ A L+S T + + G C L F+ YN G
Sbjct: 342 --GHFMFILKKSSSLWQVAKLQSPT-FSQTGPGCILSFWFYNYG 382
>gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 49.3 bits (116), Expect = 1e-05
Identities = 48/181 (26%), Positives = 78/181 (43%), Gaps = 22/181 (12%)
Query: 254 NCSSSLSFMDSCSFELEN-----VCGMIQSSGDNADWQRVSQVPRG---PESDHSNMGQC 305
+C+ S SC+FE + C + Q S D+ DW S++P P+SDH+
Sbjct: 1428 HCAHYTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHT----- 1482
Query: 306 QGSG-FFMHFDSSSVNVGATAVLESRTLYP-KRGFQCLQFYLYNSGSES-DQLNIYIREY 362
GSG F++ +SS G+ A + + +P G ++F+ Y S L +Y E
Sbjct: 1483 PGSGQHFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEE 1542
Query: 363 SADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINL 422
S N+ LV + W V L F+V FE + +++DDI+
Sbjct: 1543 SGLNI-----LVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDI-FIALDDISF 1596
Query: 423 S 423
+
Sbjct: 1597 T 1597
Score = 40.8 bits (94), Expect = 0.004
Identities = 43/167 (25%), Positives = 75/167 (44%), Gaps = 19/167 (11%)
Query: 265 CSFELENVCGMIQSSGDNADWQ-RVSQVPRG---PESDHSNMGQCQGSGFFMHFDSSSVN 320
C FE + +C Q ++ DW + S +P P +DH+ +G SG ++ S
Sbjct: 947 CDFEFD-LCSWKQEKDEDFDWNLKASSIPAAGTEPAADHT-LGN--SSGHYIFIKSLFPQ 1002
Query: 321 VGATAVLESRTLYPKRGFQC---LQFYLYNSGSESDQLNIYIREYSADNVDGNLTLVEEI 377
A S + KR C +++Y +G + L + + + V NLT+ +
Sbjct: 1003 QPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGALTL-MQVSVTNQTKVLLNLTVEQG- 1060
Query: 378 KEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSE 424
W+ ++L + F++ FEGR G G G +++DDI L+E
Sbjct: 1061 -----NFWRREELSLFGDEDFQLKFEGRVGKG-QRGDIALDDIVLTE 1101
Score = 37.0 bits (84), Expect = 0.062
Identities = 36/104 (34%), Positives = 48/104 (46%), Gaps = 16/104 (15%)
Query: 256 SSSLSFMDSCSFELENVCGMIQS-SGDNADWQRVSQVP-------RGPESDHS-NMGQCQ 306
+S+ S C FE N C ++ SGD+ DW R SQ + P DHS N Q
Sbjct: 285 TSTQSKFSKCDFEA-NSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQ-- 341
Query: 307 GSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQC-LQFYLYNSG 349
G FM S ++ A L+S T + + G C L F+ YN G
Sbjct: 342 --GHFMFILKKSSSLWQVAKLQSPT-FSQTGPGCILSFWFYNYG 382
>gi|119220585 apical early endosomal glycoprotein precursor [Homo
sapiens]
Length = 1137
Score = 47.8 bits (112), Expect = 4e-05
Identities = 47/175 (26%), Positives = 76/175 (43%), Gaps = 30/175 (17%)
Query: 265 CSFELENVCGMIQSSGDNADWQRVSQVPR----GPESDHSNMGQCQGSGFFMHFDSS--S 318
CSFE ++ CG S G W+R + GP +DH+ G +M D+S +
Sbjct: 734 CSFE-DSDCGF--SPGGQGLWRRQANASGHAAWGPPTDHTTE---TAQGHYMVVDTSPDA 787
Query: 319 VNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIREYSADNV-----DGNLTL 373
+ G TA L S+ P CL F+ + S L +Y+ E V G L
Sbjct: 788 LPRGQTASLTSKEHRPLAQPACLTFWYHGSLRSPGTLRVYLEERGRHQVLSLSAHGGL-- 845
Query: 374 VEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSETRCP 428
+W+L + ++ + +RVVFE +G + +++DD+ L + CP
Sbjct: 846 ----------AWRLGSMDVQAERAWRVVFEA-VAAGVAHSYVALDDLLLQDGPCP 889
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/134 (28%), Positives = 57/134 (42%), Gaps = 11/134 (8%)
Query: 292 PRGPESDHSNMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQC-LQFYLYNSGS 350
P P DHS QGS F S G A+L S C L FY Y SGS
Sbjct: 298 PSWPRRDHSR-NSAQGS-----FLVSVAEPGTPAILSSPEFQASGTSNCSLVFYQYLSGS 351
Query: 351 ESDQLNIYIREYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGA 410
E+ L ++++ + L E+ T +W V ++ F+++ G+ G G
Sbjct: 352 EAGCLQLFLQTLGPGAPRAPVLLRRRRGELGT-AWVRDRVDIQSAYPFQILLAGQTGPGG 410
Query: 411 SLGGLSIDDINLSE 424
+G +DD+ LS+
Sbjct: 411 VVG---LDDLILSD 421
Score = 32.7 bits (73), Expect = 1.2
Identities = 39/167 (23%), Positives = 66/167 (39%), Gaps = 20/167 (11%)
Query: 264 SCSFELENVCGMIQSS-----GDNADWQRVSQVPRGPES--DHSNMGQCQGSGFFMHFDS 316
SC FE +CG + G + DW + R P+ DH+ + +G F F++
Sbjct: 893 SCDFE-SGLCGWSHLAWPGLGGYSWDWGGGATPSRYPQPPVDHTLGTE---AGHFAFFET 948
Query: 317 SSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSE---SDQLNIYIREYSADNVDGNLTL 373
+ G A P CL+F+ + E +L + + + G L
Sbjct: 949 GVLGPGGRAAWLRSEPLPATPASCLRFWYHMGFPEHFYKGELKVLLH-----SAQGQLA- 1002
Query: 374 VEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDI 420
V W V + K+F++VFE G +LG +++DD+
Sbjct: 1003 VWGAGGHRRHQWLEAQVEVASAKEFQIVFEATLGGQPALGPIALDDV 1049
>gi|16554449 zonadhesin isoform 3 [Homo sapiens]
Length = 2812
Score = 45.4 bits (106), Expect = 2e-04
Identities = 47/182 (25%), Positives = 77/182 (42%), Gaps = 33/182 (18%)
Query: 262 MDSCSFE--LENVCGMIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFFMHFDSSSV 319
+ C FE + +C Q S D+ DW R S P S + G G G ++H +S+S
Sbjct: 38 LTQCDFEDDAKPLCDWSQVSADDEDWVRASG-PSPTGSTGAPGGYPNGEGSYLHMESNSF 96
Query: 320 NVGATAVLESRTLYPKRGFQCLQF--------------YLYNSGSESDQLNIYIREYSAD 365
+ G A L S L+ ++G C+ F L SG E + ++ + ++
Sbjct: 97 HRGGVARLLSPDLW-EQGPLCVHFAHHMFGLSWGAQLRLLLLSGEEGRRPDVLWKHWNTQ 155
Query: 366 NVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSET 425
LT V +P G T R++FEG +GS A L +++D +++
Sbjct: 156 RPSWMLTTV----TVPAG----------FTLPTRLMFEGTRGSTAYL-DIALDALSIRRG 200
Query: 426 RC 427
C
Sbjct: 201 SC 202
Score = 38.1 bits (87), Expect = 0.028
Identities = 22/90 (24%), Positives = 38/90 (42%), Gaps = 11/90 (12%)
Query: 608 CSKTTCKNDGVCTVRDGKAECRCQSGEDWWYMGERCEK-------RGSTRDTIVIAVSST 660
C + C+NDG C + C C+ G Y G C + R + + + +
Sbjct: 2712 CLQNPCQNDGQCREQGATFTCECEVG----YGGGLCMEPRDAPPPRKPASNLVAVLLGLL 2767
Query: 661 VAVFALMLIITLVSVYCTRKKYRERMSSNR 690
V V ++L +T +Y TR+K + +R
Sbjct: 2768 VPVVVVLLAVTRECIYRTRRKREKTQEGDR 2797
>gi|27881494 zonadhesin isoform 6 [Homo sapiens]
Length = 2721
Score = 45.4 bits (106), Expect = 2e-04
Identities = 47/182 (25%), Positives = 77/182 (42%), Gaps = 33/182 (18%)
Query: 262 MDSCSFE--LENVCGMIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFFMHFDSSSV 319
+ C FE + +C Q S D+ DW R S P S + G G G ++H +S+S
Sbjct: 38 LTQCDFEDDAKPLCDWSQVSADDEDWVRASG-PSPTGSTGAPGGYPNGEGSYLHMESNSF 96
Query: 320 NVGATAVLESRTLYPKRGFQCLQF--------------YLYNSGSESDQLNIYIREYSAD 365
+ G A L S L+ ++G C+ F L SG E + ++ + ++
Sbjct: 97 HRGGVARLLSPDLW-EQGPLCVHFAHHMFGLSWGAQLRLLLLSGEEGRRPDVLWKHWNTQ 155
Query: 366 NVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSET 425
LT V +P G T R++FEG +GS A L +++D +++
Sbjct: 156 RPSWMLTTV----TVPAG----------FTLPTRLMFEGTRGSTAYL-DIALDALSIRRG 200
Query: 426 RC 427
C
Sbjct: 201 SC 202
Score = 38.1 bits (87), Expect = 0.028
Identities = 22/90 (24%), Positives = 38/90 (42%), Gaps = 11/90 (12%)
Query: 608 CSKTTCKNDGVCTVRDGKAECRCQSGEDWWYMGERCEK-------RGSTRDTIVIAVSST 660
C + C+NDG C + C C+ G Y G C + R + + + +
Sbjct: 2621 CLQNPCQNDGQCREQGATFTCECEVG----YGGGLCMEPRDAPPPRKPASNLVAVLLGLL 2676
Query: 661 VAVFALMLIITLVSVYCTRKKYRERMSSNR 690
V V ++L +T +Y TR+K + +R
Sbjct: 2677 VPVVVVLLAVTRECIYRTRRKREKTQEGDR 2706
>gi|22027612 TNF receptor-associated factor 2 [Homo sapiens]
Length = 501
Score = 44.7 bits (104), Expect = 3e-04
Identities = 30/85 (35%), Positives = 46/85 (54%), Gaps = 11/85 (12%)
Query: 431 IWHIRNFT----QFIGSPNGTLYSPPFYSSK-GY--AFQIYLN---LAHVTNAGIYFHLI 480
IW I +F + + ++SP FY+S+ GY +IYLN T+ ++F ++
Sbjct: 355 IWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVM 414
Query: 481 SGANDDQLQWPCPWQQATMTLLDQN 505
G ND L+WP Q+ T+ LLDQN
Sbjct: 415 KGPNDALLRWPFN-QKVTLMLLDQN 438
>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
Length = 844
Score = 42.7 bits (99), Expect = 0.001
Identities = 36/130 (27%), Positives = 59/130 (45%), Gaps = 19/130 (14%)
Query: 584 TVEDISHLNSTQIQLTPAPSVQDLCSKTT---CKNDGVCTVRDG--KAECRCQSGEDWWY 638
TV ++NS L+ C++T C N GVC +G + C+C G Y
Sbjct: 321 TVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVG----Y 376
Query: 639 MGERCE--------KRGSTRDTIVIAVSSTVAVFALMLIITLVSVYCTRKKYRERMSSN- 689
G+RC+ K V+ ++ + V L++ I V YC KK R++M ++
Sbjct: 377 TGDRCQQFAMVNFSKAEELYQKRVLTITG-ICVALLVVGIVCVVAYCKTKKQRKQMHNHL 435
Query: 690 RPNLTPQNQH 699
R N+ P +Q+
Sbjct: 436 RQNMCPAHQN 445
>gi|22027616 TNF receptor-associated factor 3 isoform 1 [Homo
sapiens]
Length = 568
Score = 42.4 bits (98), Expect = 0.001
Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 33/166 (19%)
Query: 431 IWHIRNFT----QFIGSPNGTLYSPPFYSSK-GYAF--QIYLN---LAHVTNAGIYFHLI 480
IW IR++ + + +LYS PFY+ GY ++YLN + T+ ++F ++
Sbjct: 419 IWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIM 478
Query: 481 SGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVG 540
G D L WP Q+ T+ L+DQ + R D F N + F +P+
Sbjct: 479 RGEYDALLPWPFK-QKVTLMLMDQ--------GSSRRHLGDAFKPDPNSSSF-KKPTGEM 528
Query: 541 TVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVE 586
+A G F+ L++ +IK D ++I + V+
Sbjct: 529 NIA-------------SGCPVFVAQTVLENGTYIKDDTIFIKVIVD 561
>gi|22027620 TNF receptor-associated factor 3 isoform 2 [Homo
sapiens]
Length = 543
Score = 42.4 bits (98), Expect = 0.001
Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 33/166 (19%)
Query: 431 IWHIRNFT----QFIGSPNGTLYSPPFYSSK-GYAF--QIYLN---LAHVTNAGIYFHLI 480
IW IR++ + + +LYS PFY+ GY ++YLN + T+ ++F ++
Sbjct: 394 IWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIM 453
Query: 481 SGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVG 540
G D L WP Q+ T+ L+DQ + R D F N + F +P+
Sbjct: 454 RGEYDALLPWPFK-QKVTLMLMDQ--------GSSRRHLGDAFKPDPNSSSF-KKPTGEM 503
Query: 541 TVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVE 586
+A G F+ L++ +IK D ++I + V+
Sbjct: 504 NIA-------------SGCPVFVAQTVLENGTYIKDDTIFIKVIVD 536
>gi|22027618 TNF receptor-associated factor 3 isoform 1 [Homo
sapiens]
Length = 568
Score = 42.4 bits (98), Expect = 0.001
Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 33/166 (19%)
Query: 431 IWHIRNFT----QFIGSPNGTLYSPPFYSSK-GYAF--QIYLN---LAHVTNAGIYFHLI 480
IW IR++ + + +LYS PFY+ GY ++YLN + T+ ++F ++
Sbjct: 419 IWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIM 478
Query: 481 SGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVG 540
G D L WP Q+ T+ L+DQ + R D F N + F +P+
Sbjct: 479 RGEYDALLPWPFK-QKVTLMLMDQ--------GSSRRHLGDAFKPDPNSSSF-KKPTGEM 528
Query: 541 TVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVE 586
+A G F+ L++ +IK D ++I + V+
Sbjct: 529 NIA-------------SGCPVFVAQTVLENGTYIKDDTIFIKVIVD 561
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform
2 precursor [Homo sapiens]
Length = 1452
Score = 40.4 bits (93), Expect = 0.006
Identities = 48/181 (26%), Positives = 80/181 (44%), Gaps = 22/181 (12%)
Query: 260 SFMDSCSF-ELENVCGMIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFFMHFDSSS 318
+F C F E + CG QS GD+ +W++V+ + + P SD SG FM ++S
Sbjct: 22 TFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTK-PTSD-----PWMPSGSFMLVNASG 75
Query: 319 VNVGATAVLESRTLYPKRGFQCLQFYLY---NSGSESDQLNIYIREYSADNVDGNLTLVE 375
G A L L + C+ F+ + S S LN+Y++ + GN +
Sbjct: 76 RPEGQRAHLLLPQL-KENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPL--GN--PIW 130
Query: 376 EIKEIPTGSWQLYHVTLKV--TKKFRVVFEGRKGSGASLGGLSIDDINLSE---TRCPHH 430
I PT +W + + ++V+FE + G L+ID++ + TR PH
Sbjct: 131 NISGDPTRTWNRAELAISTFWPNFYQVIFE--VITSGHQGYLAIDEVKVLGHPCTRTPHF 188
Query: 431 I 431
+
Sbjct: 189 L 189
>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
Length = 850
Score = 40.4 bits (93), Expect = 0.006
Identities = 35/136 (25%), Positives = 60/136 (44%), Gaps = 25/136 (18%)
Query: 584 TVEDISHLNSTQIQLTPAPSVQDLCSKTT---CKNDGVCTVRDG--KAECRCQSGEDWWY 638
TV ++NS L+ C++T C N GVC +G + C+C +G +
Sbjct: 321 TVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNG----F 376
Query: 639 MGERC--------------EKRGSTRDTIVIAVSSTVAVFALMLIITLVSVYCTRKKYRE 684
G+RC +K V+ ++ + V L++ I V YC KK R+
Sbjct: 377 FGQRCLEKLPLRLYMPDPKQKAEELYQKRVLTITG-ICVALLVVGIVCVVAYCKTKKQRK 435
Query: 685 RMSSN-RPNLTPQNQH 699
+M ++ R N+ P +Q+
Sbjct: 436 QMHNHLRQNMCPAHQN 451
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform
1 precursor [Homo sapiens]
Length = 1465
Score = 40.4 bits (93), Expect = 0.006
Identities = 48/181 (26%), Positives = 80/181 (44%), Gaps = 22/181 (12%)
Query: 260 SFMDSCSF-ELENVCGMIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFFMHFDSSS 318
+F C F E + CG QS GD+ +W++V+ + + P SD SG FM ++S
Sbjct: 22 TFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTK-PTSD-----PWMPSGSFMLVNASG 75
Query: 319 VNVGATAVLESRTLYPKRGFQCLQFYLY---NSGSESDQLNIYIREYSADNVDGNLTLVE 375
G A L L + C+ F+ + S S LN+Y++ + GN +
Sbjct: 76 RPEGQRAHLLLPQL-KENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPL--GN--PIW 130
Query: 376 EIKEIPTGSWQLYHVTLKV--TKKFRVVFEGRKGSGASLGGLSIDDINLSE---TRCPHH 430
I PT +W + + ++V+FE + G L+ID++ + TR PH
Sbjct: 131 NISGDPTRTWNRAELAISTFWPNFYQVIFE--VITSGHQGYLAIDEVKVLGHPCTRTPHF 188
Query: 431 I 431
+
Sbjct: 189 L 189
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,444,189
Number of Sequences: 37866
Number of extensions: 1174180
Number of successful extensions: 3017
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 62
Number of HSP's that attempted gapping in prelim test: 2747
Number of HSP's gapped (non-prelim): 313
length of query: 701
length of database: 18,247,518
effective HSP length: 109
effective length of query: 592
effective length of database: 14,120,124
effective search space: 8359113408
effective search space used: 8359113408
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.