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Search of human proteins with 15149467
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15149467 caldesmon 1 isoform 3 [Homo sapiens]
(564 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15149467 caldesmon 1 isoform 3 [Homo sapiens] 1104 0.0
gi|15149463 caldesmon 1 isoform 4 [Homo sapiens] 1058 0.0
gi|4826657 caldesmon 1 isoform 2 [Homo sapiens] 1038 0.0
gi|15149465 caldesmon 1 isoform 5 [Homo sapiens] 993 0.0
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 742 0.0
gi|148746195 trichohyalin [Homo sapiens] 115 8e-26
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 110 3e-24
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 109 8e-24
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 108 1e-23
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 106 5e-23
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 104 2e-22
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 100 6e-21
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 100 6e-21
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 96 1e-19
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 92 1e-18
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 92 1e-18
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 92 1e-18
gi|148839339 nexilin (F actin binding protein) [Homo sapiens] 92 1e-18
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 89 1e-17
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 88 2e-17
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 86 7e-17
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 86 7e-17
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 85 2e-16
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 85 2e-16
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 85 2e-16
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 85 2e-16
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 85 2e-16
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 85 2e-16
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 85 2e-16
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 85 2e-16
>gi|15149467 caldesmon 1 isoform 3 [Homo sapiens]
Length = 564
Score = 1104 bits (2855), Expect = 0.0
Identities = 564/564 (100%), Positives = 564/564 (100%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG
Sbjct: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE
Sbjct: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA
Sbjct: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIK 240
EENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIK
Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIK 240
Query: 241 KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 300
KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ
Sbjct: 241 KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 300
Query: 301 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 360
VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE
Sbjct: 301 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 360
Query: 361 EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER 420
EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER
Sbjct: 361 EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER 420
Query: 421 AEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGV 480
AEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGV
Sbjct: 421 AEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGV 480
Query: 481 RNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRP 540
RNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRP
Sbjct: 481 RNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRP 540
Query: 541 GDVSSKRNLWEKQSVDKVTSPTKV 564
GDVSSKRNLWEKQSVDKVTSPTKV
Sbjct: 541 GDVSSKRNLWEKQSVDKVTSPTKV 564
>gi|15149463 caldesmon 1 isoform 4 [Homo sapiens]
Length = 558
Score = 1058 bits (2736), Expect = 0.0
Identities = 540/541 (99%), Positives = 541/541 (100%)
Query: 24 RIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 83
+IAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT
Sbjct: 18 QIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 77
Query: 84 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 143
TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE
Sbjct: 78 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 137
Query: 144 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 203
NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI
Sbjct: 138 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 197
Query: 204 GENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVK 263
GENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVK
Sbjct: 198 GENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVK 257
Query: 264 SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE 323
SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE
Sbjct: 258 SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE 317
Query: 324 KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR 383
KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR
Sbjct: 318 KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR 377
Query: 384 AEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIV 443
AEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIV
Sbjct: 378 AEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIV 437
Query: 444 SKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPN 503
SKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPN
Sbjct: 438 SKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPN 497
Query: 504 KETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTK 563
KETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTK
Sbjct: 498 KETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTK 557
Query: 564 V 564
V
Sbjct: 558 V 558
Score = 54.7 bits (130), Expect = 2e-07
Identities = 57/262 (21%), Positives = 117/262 (44%), Gaps = 21/262 (8%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E + E R+++ E E +YQ+ND D EE +E + + +E +K + S+G
Sbjct: 144 EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE--EEKPKRGSIG--- 198
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
+N ++ K +++ +D+ F ++EE + +++++ E ++E
Sbjct: 199 -------ENQGEEKGTKVQAKREKLQ-EDKPTF-----KKEEIKDEKIKKDKEPKEEV-K 244
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
+ D + QN + E + SR +T+ + Q + EE
Sbjct: 245 SFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEEL 304
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDK 243
++ E E EE EK K+ E+ K + +R K+ E++ +K+E D K+++++
Sbjct: 305 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEE 364
Query: 244 EPKEEVKSFMDRKKGFTEVKSQ 265
E K +K ++R++ K Q
Sbjct: 365 E-KRRLKEEIERRRAEAAEKRQ 385
Score = 33.5 bits (75), Expect = 0.53
Identities = 36/177 (20%), Positives = 77/177 (43%), Gaps = 39/177 (22%)
Query: 1 MDDFERRR--------ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQ 52
+++ RRR E +QK++E LE E + +R ++ + E +RR ++E R+
Sbjct: 301 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR-EERRKVLEEEEQRRKQEEADRK 359
Query: 53 KQEEESLGQVTDQVE------VNAQNSVPDEEAKT--------TTTNTQVEGDDEAAFLE 98
+EEE ++ +++E + +P++ T + ++ ++ A FL
Sbjct: 360 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLN 419
Query: 99 RLARRE---------------ERRQKRLQEALERQKEFDPTITDAS-LSLPSRRMQN 139
+ ++ + R ++ A+E K PT AS L +P+ ++N
Sbjct: 420 KSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRN 476
Score = 30.8 bits (68), Expect = 3.4
Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 27/166 (16%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
+R ELRR++ E E E++ + E E ++ R+ER + +EEE
Sbjct: 299 KRLEELRRRRGETESEEFEKL---KQKQQEAALELEELKKKREERRKVLEEEEQ-----R 350
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ + A + +EE K ++E R A E+RQK ++ L K+
Sbjct: 351 RKQEEADRKLREEEEK-RRLKEEIE--------RRRAEAAEKRQKMPEDGLSDDKKPFKC 401
Query: 125 ITDASLSLP--------SRRMQNDTAENETTEKE--EKSESRQERY 160
T SL ++ +Q + T + K +SR E+Y
Sbjct: 402 FTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQY 447
>gi|4826657 caldesmon 1 isoform 2 [Homo sapiens]
Length = 538
Score = 1038 bits (2685), Expect = 0.0
Identities = 538/564 (95%), Positives = 538/564 (95%), Gaps = 26/564 (4%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG
Sbjct: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE
Sbjct: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA
Sbjct: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIK 240
EENKKEDKEKEEEEEEKPKRGSIGENQ IKDEKIK
Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQ--------------------------IKDEKIK 214
Query: 241 KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 300
KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ
Sbjct: 215 KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 274
Query: 301 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 360
VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE
Sbjct: 275 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 334
Query: 361 EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER 420
EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER
Sbjct: 335 EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER 394
Query: 421 AEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGV 480
AEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGV
Sbjct: 395 AEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGV 454
Query: 481 RNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRP 540
RNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRP
Sbjct: 455 RNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRP 514
Query: 541 GDVSSKRNLWEKQSVDKVTSPTKV 564
GDVSSKRNLWEKQSVDKVTSPTKV
Sbjct: 515 GDVSSKRNLWEKQSVDKVTSPTKV 538
>gi|15149465 caldesmon 1 isoform 5 [Homo sapiens]
Length = 532
Score = 993 bits (2566), Expect = 0.0
Identities = 514/541 (95%), Positives = 515/541 (95%), Gaps = 26/541 (4%)
Query: 24 RIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 83
+IAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT
Sbjct: 18 QIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 77
Query: 84 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 143
TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE
Sbjct: 78 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 137
Query: 144 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 203
NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI
Sbjct: 138 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 197
Query: 204 GENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVK 263
GENQ IKDEKIKKDKEPKEEVKSFMDRKKGFTEVK
Sbjct: 198 GENQ--------------------------IKDEKIKKDKEPKEEVKSFMDRKKGFTEVK 231
Query: 264 SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE 323
SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE
Sbjct: 232 SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE 291
Query: 324 KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR 383
KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR
Sbjct: 292 KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR 351
Query: 384 AEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIV 443
AEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIV
Sbjct: 352 AEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIV 411
Query: 444 SKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPN 503
SKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPN
Sbjct: 412 SKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPN 471
Query: 504 KETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTK 563
KETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTK
Sbjct: 472 KETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTK 531
Query: 564 V 564
V
Sbjct: 532 V 532
Score = 57.4 bits (137), Expect = 3e-08
Identities = 64/276 (23%), Positives = 122/276 (44%), Gaps = 19/276 (6%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E + E R+++ E E +YQ+ND D EE +E + + +E +K + S+G+
Sbjct: 144 EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE--EEKPKRGSIGENQ 201
Query: 64 DQVEVNAQNSVPDEEAKTTTTN----TQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
+ E ++ P EE K+ T+V+ + +L E + A K
Sbjct: 202 IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTK 261
Query: 120 EFD--PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDW 177
E + P + +A L R + E+E EK K + ++ E+EE + + +K
Sbjct: 262 EAEGAPQV-EAGKRLEELRRRRGETESEEFEK-LKQKQQEAALELEELKKKREERRKVLE 319
Query: 178 RDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE 237
+ + K+E+ +++ EEE+ +R + + E + + KR+K+ ED + K+ K
Sbjct: 320 EEEQRRKQEEADRKLREEEEKRR---LKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCF 376
Query: 238 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHK 273
K EE F+++ V+ +G TH+
Sbjct: 377 TPKGSSLKIEERAEFLNK-----SVQKSSGVKSTHQ 407
Score = 51.6 bits (122), Expect = 2e-06
Identities = 63/280 (22%), Positives = 114/280 (40%), Gaps = 37/280 (13%)
Query: 7 RRELRRQKREEMRLEAER--------------IAYQRNDDDEEEAA-RERRRRARQERLR 51
RRE RRQKR + LE ++ +ND E E +E + +RQER
Sbjct: 96 RREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQER-- 153
Query: 52 QKQEEESLGQVTDQVEVN-----AQNSVPDEEAKTTTTNTQVEGD-DEAAFLERLARREE 105
E E VT + N +N D+E + G E + ++++
Sbjct: 154 --YEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDK 211
Query: 106 RRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEET 165
++ ++ ++R+K F + QN + E + SR +T
Sbjct: 212 EPKEEVKSFMDRKKGFTEV-----------KSQNGEFMTHKLKHTENTFSRPGGRASVDT 260
Query: 166 ETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQED 225
+ + Q + EE ++ E E EE EK K+ E+ K + +R K+ E+
Sbjct: 261 KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE 320
Query: 226 KPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 265
+ +K+E D K+++++E K +K ++R++ K Q
Sbjct: 321 EEQRRKQEEADRKLREEEE-KRRLKEEIERRRAEAAEKRQ 359
Score = 33.5 bits (75), Expect = 0.53
Identities = 36/177 (20%), Positives = 77/177 (43%), Gaps = 39/177 (22%)
Query: 1 MDDFERRR--------ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQ 52
+++ RRR E +QK++E LE E + +R ++ + E +RR ++E R+
Sbjct: 275 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR-EERRKVLEEEEQRRKQEEADRK 333
Query: 53 KQEEESLGQVTDQVE------VNAQNSVPDEEAKT--------TTTNTQVEGDDEAAFLE 98
+EEE ++ +++E + +P++ T + ++ ++ A FL
Sbjct: 334 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLN 393
Query: 99 RLARRE---------------ERRQKRLQEALERQKEFDPTITDAS-LSLPSRRMQN 139
+ ++ + R ++ A+E K PT AS L +P+ ++N
Sbjct: 394 KSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRN 450
Score = 30.8 bits (68), Expect = 3.4
Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 27/166 (16%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
+R ELRR++ E E E++ + E E ++ R+ER + +EEE
Sbjct: 273 KRLEELRRRRGETESEEFEKL---KQKQQEAALELEELKKKREERRKVLEEEEQ-----R 324
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ + A + +EE K ++E R A E+RQK ++ L K+
Sbjct: 325 RKQEEADRKLREEEEK-RRLKEEIE--------RRRAEAAEKRQKMPEDGLSDDKKPFKC 375
Query: 125 ITDASLSLP--------SRRMQNDTAENETTEKE--EKSESRQERY 160
T SL ++ +Q + T + K +SR E+Y
Sbjct: 376 FTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQY 421
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 742 bits (1915), Expect = 0.0
Identities = 407/572 (71%), Positives = 440/572 (76%), Gaps = 37/572 (6%)
Query: 16 EEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVP 75
EE + E ER E+ E + RA ER R + EE ++++ +
Sbjct: 236 EEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEER------ERIKAEQDKKIA 289
Query: 76 DEEAKTTTTNTQVEGDDEAAFLERLARREERRQ------KRLQEALERQKEFDPTITDAS 129
DE A+ +E +++AA ER R E R+ KR E +R KE + +
Sbjct: 290 DERAR-------IEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEER 342
Query: 130 LSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK---KE 186
+ + E+E+++ ++R EE E QK + + EE K +E
Sbjct: 343 QRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRN-KQLEEKKHAMQE 401
Query: 187 DKEKEEEEEEKPKRGSIGEN--------------QGEEKGTKVQAKREKLQEDKPTFKKE 232
K K E+ E+K + + E QGEEKGTKVQAKREKLQEDKPTFKKE
Sbjct: 402 TKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKE 461
Query: 233 EIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT 292
EIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT
Sbjct: 462 EIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT 521
Query: 293 KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE 352
KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE
Sbjct: 522 KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE 581
Query: 353 EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG 412
EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG
Sbjct: 582 EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG 641
Query: 413 SSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 472
SSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD
Sbjct: 642 SSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 701
Query: 473 LPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPA 532
LPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPA
Sbjct: 702 LPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPA 761
Query: 533 PKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 564
PKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV
Sbjct: 762 PKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 793
Score = 464 bits (1195), Expect = e-131
Identities = 293/555 (52%), Positives = 357/555 (64%), Gaps = 28/555 (5%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG
Sbjct: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE
Sbjct: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA
Sbjct: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDK--PTFKKEEIKDEK 238
EENKKEDKEKEEEEEEKPKRGSIGENQ E V+ K + QE+ + K +I E+
Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQVE---VMVEEKTTESQEETVVMSLKNGQISSEE 237
Query: 239 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGA 298
K+++E +E+ + + E + E +L+ E R +A D K A+
Sbjct: 238 PKQEEE-REQGSDEISHHEKMEEEDKERAEAERARLEAEE----RERIKAEQDKKIADER 292
Query: 299 PQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRK 358
++EA ++ R R E+EE E+++++++ AA E + +K+ EE+R EE QR K
Sbjct: 293 ARIEAEEKAAAQERER--REAEERERMREEEKRAAEERQRIKE--EEKRAA--EERQRIK 346
Query: 359 QEE---ADRKLREEEEKRRLKEEIERRRAEAAEK---RQKMPEDGLSDDKKPFKCFTPKG 412
+EE A+ + R +EE++R EE +R RAE EK ++ L + K + KG
Sbjct: 347 EEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKG 406
Query: 413 SSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 472
K+E++ E K V + + Q A++ K E+ T + + KP
Sbjct: 407 E--KVEQKIE--GKWVNEKKAQEDKLQTAVLKKQGE--EKGTKVQAKREKLQEDKPTFKK 460
Query: 473 LPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPA 532
+ E ++ K E+ F T K G + + E P G S
Sbjct: 461 EEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD 520
Query: 533 PKPSDLRPGDVSSKR 547
K ++ P + KR
Sbjct: 521 TKEAEGAPQVEAGKR 535
Score = 33.5 bits (75), Expect = 0.53
Identities = 36/177 (20%), Positives = 77/177 (43%), Gaps = 39/177 (22%)
Query: 1 MDDFERRR--------ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQ 52
+++ RRR E +QK++E LE E + +R ++ + E +RR ++E R+
Sbjct: 536 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR-EERRKVLEEEEQRRKQEEADRK 594
Query: 53 KQEEESLGQVTDQVE------VNAQNSVPDEEAKT--------TTTNTQVEGDDEAAFLE 98
+EEE ++ +++E + +P++ T + ++ ++ A FL
Sbjct: 595 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLN 654
Query: 99 RLARRE---------------ERRQKRLQEALERQKEFDPTITDAS-LSLPSRRMQN 139
+ ++ + R ++ A+E K PT AS L +P+ ++N
Sbjct: 655 KSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRN 711
Score = 30.8 bits (68), Expect = 3.4
Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 27/166 (16%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
+R ELRR++ E E E++ + E E ++ R+ER + +EEE
Sbjct: 534 KRLEELRRRRGETESEEFEKL---KQKQQEAALELEELKKKREERRKVLEEEEQ-----R 585
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ + A + +EE K ++E R A E+RQK ++ L K+
Sbjct: 586 RKQEEADRKLREEEEK-RRLKEEIE--------RRRAEAAEKRQKMPEDGLSDDKKPFKC 636
Query: 125 ITDASLSLP--------SRRMQNDTAENETTEKE--EKSESRQERY 160
T SL ++ +Q + T + K +SR E+Y
Sbjct: 637 FTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQY 682
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 115 bits (289), Expect = 8e-26
Identities = 111/489 (22%), Positives = 223/489 (45%), Gaps = 39/489 (7%)
Query: 7 RRELRRQKREEMRLEAE--RIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
R+ELRR+++EE + + R R +EE ++ RR +QER R++QEE Q+
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER-REQQEERREQQLRR 341
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE--RRQKRLQEALERQKEFD 122
+ E + + E+ + Q+ + E E+ RRE+ RR+++L+ + ++E
Sbjct: 342 EQEERREQQLRREQ-EEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQ 400
Query: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQ--KNDWRDA 180
R + + +E++ E ++++E E E K Q + DW
Sbjct: 401 LRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWL-- 458
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIK 240
++E+ E+ E+E K + E + E+ K++ + + Q+++ + ++E+ +
Sbjct: 459 --KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERRE 516
Query: 241 KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 300
+ + +EE + R + +++ + E LK E R +E E +
Sbjct: 517 QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQE-ERR 575
Query: 301 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 360
+ KR EE R++R + E E E+L+Q+ + +E E +++RE+R K E EE+RR+Q
Sbjct: 576 DQLLKREEERRQQRLKREQE--ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQ- 632
Query: 361 EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER 420
L+ EE++ R ++++ R + E E+R K E+ ++E+R
Sbjct: 633 ----LLKSEEQEERRQQQLRREQQERREQRLKREEE-----------------EERLEQR 671
Query: 421 AEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGV 480
+ ++ ++ + Q +I SR+ ++ +E A+ +K P EG
Sbjct: 672 LKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK--VYSRPRKQEGQ 729
Query: 481 RNIKSMWEK 489
R + EK
Sbjct: 730 RRRQEQEEK 738
Score = 112 bits (280), Expect = 9e-25
Identities = 109/428 (25%), Positives = 200/428 (46%), Gaps = 53/428 (12%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQ-----EEESLG 60
RR+EL RQ REE L+ E R + ++ RER+ R +E RQK+ +E+
Sbjct: 1162 RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221
Query: 61 QVTDQVEVNAQNSVPD----------------EEAKTTTTNTQVE-----GDDEAAFLER 99
+ Q E +N+V D E+++ +Q + G+ + E+
Sbjct: 1222 DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQ 1281
Query: 100 LARREERRQKRL--QEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQ 157
RR ++R + +E LER+++ + D S +++ + E + +E + R+
Sbjct: 1282 ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK-SQEEKQLLREEREEKRRRQETDRKFRE 1340
Query: 158 ERYEIEETETVTKSYQKND--WRDAEENKKEDKEKEEEEEEKPKRGSIGEN-QGEEKGTK 214
E ++E E Q+ D +R+ E +E K EEE++ +R EE+ +
Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR 1400
Query: 215 VQAKREKLQEDKPT-FKKEEIKDEKIKKDKEPKEEVKSF--MDRKKGFTEVKSQNGEFMT 271
Q + ++L++D+ F++EE + + ++D++ +EE + +R++ F E + Q +
Sbjct: 1401 CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460
Query: 272 HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEE---LRRRRGETESEEFEKLKQK 328
K + E + +E + Q K LEE LRR+ + + E E Q+
Sbjct: 1461 RKFREEEQLLQ--------EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQE 1512
Query: 329 QQEAALELEELKKKREERRKVLEEEEQRRKQE-------EADRKLREEEEKRRLKEEIER 381
+ LE E+ +++ +RK L+EE+Q R+QE + DRK REEE+ R+ +EE +
Sbjct: 1513 PERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQL 1572
Query: 382 RRAEAAEK 389
R E K
Sbjct: 1573 SRQERDRK 1580
Score = 110 bits (274), Expect = 4e-24
Identities = 113/495 (22%), Positives = 213/495 (43%), Gaps = 74/495 (14%)
Query: 5 ERRRELRRQKREEMRLEAERIAY----QRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
E EL+R++RE+ R + + Y Q ++E+ ER +R RQER RQ ++++ L
Sbjct: 908 EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967
Query: 61 QVTDQV---------------EVNAQNSVPDEE----------AKTTTTNTQVEGDDEAA 95
Q +Q+ + + + EE + Q DE
Sbjct: 968 QKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQ 1027
Query: 96 FLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETT-EKEEKSE 154
E REER ++RLQE + +E + + L R E E KEE+ +
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQ 1087
Query: 155 SRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTK 214
+E+ EE E + ++ R+ EE ++E+++ EE EK +R + EE+ +
Sbjct: 1088 QEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQ 1147
Query: 215 VQAKR---------------------EKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFM 253
+ ++ E+LQ+++ +EE + + +++++ +EE +
Sbjct: 1148 QEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQR 1207
Query: 254 DRKKGFTEVKSQNGEFMTHKLKHTENTFSRP----GGRASVDTKEAEGAPQVEAGKRLEE 309
++K + Q + EN GR + ++ E + Q+ + ++
Sbjct: 1208 QKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDS-QLRDRQSQQD 1266
Query: 310 LRRRRGETESEEFEKLKQKQQ--------EAALELEELK-------KKREERRKVLEEEE 354
L+ GE + + E+ +++ Q E LE EE K K +EE++ + EE E
Sbjct: 1267 LQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREERE 1326
Query: 355 QRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSS 414
++R+++E DRK REEE+ + +EE RR E+ +K E+ L ++ K +
Sbjct: 1327 EKRRRQETDRKFREEEQLLQEREEQPLRR---QERDRKFREEELRHQEQGRKFLEEEQRL 1383
Query: 415 LKIEERAEFLNKSVQ 429
+ E +FL + Q
Sbjct: 1384 RRQERERKFLKEEQQ 1398
Score = 107 bits (267), Expect = 3e-23
Identities = 102/398 (25%), Positives = 197/398 (49%), Gaps = 28/398 (7%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
E RRE + ++ +++R E E QR EEE ++R R+ Q+ LR++QEE +
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ-LRREQEERREQLLKR 552
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRL----QEALERQKE 120
+ E + ++ K Q E D+ L R EERRQ+RL +E LE++ +
Sbjct: 553 EEEKRLEQERREQRLK----REQEERRDQL-----LKREEERRQQRLKREQEERLEQRLK 603
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ +R++ + E E ++ KSE ++ER + + + ++ R+
Sbjct: 604 REEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREE 663
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQ---EDKPTFKKEEIKDE 237
EE + E + K E EEE+ ++ + E + E+ +++++ K Q E + ++ ++
Sbjct: 664 EEERLEQRLKREHEEERREQ-ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR 722
Query: 238 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEG 297
K++ + + + + R++ +E++ Q E H+ + E + + K G
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRE-SELQWQEEE-RAHRQQQEEEQRRDFTWQWQAEEKSERG 780
Query: 298 APQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRK---VLEEEE 354
++ A L E R R + +EE ++ +Q+ E E+ +++R ER K LEEEE
Sbjct: 781 RQRLSARPPLREQRER--QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEE 838
Query: 355 QRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 392
Q +++E A ++L+EEE+ L+E+ ERRR++ + QK
Sbjct: 839 QLQRRERA-QQLQEEEDG--LQEDQERRRSQEQRRDQK 873
Score = 107 bits (266), Expect = 4e-23
Identities = 112/460 (24%), Positives = 220/460 (47%), Gaps = 61/460 (13%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRND----DDEEEAARERRRRA--------RQERLRQ 52
ER ++LR+ + + R E ++++ Q D ++E++ R+ R R RQER R+
Sbjct: 1403 EREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK 1462
Query: 53 KQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDD-EAAFLERLARREERRQKRL 111
+EEE L Q ++ +++ Q + + K Q+ + + F E+ R +E +K L
Sbjct: 1463 FREEEQLLQEREEQQLHRQ----ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFL 1518
Query: 112 QEA--LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVT 169
+E L RQ+ + + R Q + + +EE+ + RQER E + ++
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE-QLRQER----EEQQLS 1573
Query: 170 KSYQKNDWRDAEEN-KKEDKEKEEEEEEKPKRGSIGENQ-GEEKGTKVQAKREKLQEDKP 227
+ + +R E+ +++++E++ E+E+ R G+ Q +E+ K + + LQE +
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE 1633
Query: 228 TFKKEEIKDEKIKKDK------EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTF 281
+ +D K +++ E +++++ DRK E Q GE +L+ E
Sbjct: 1634 QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE--EQQLRRQER-- 1689
Query: 282 SRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKK 341
D K E Q+ +R + + + +E E+ +++++ E E+ +
Sbjct: 1690 ---------DRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740
Query: 342 KREER-RKVLEEE-------EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK---- 389
+R+ER RK+LEEE EQ+ +++E DRK REEE+ R+ +EE + R E+ K
Sbjct: 1741 RRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREE 1800
Query: 390 ---RQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNK 426
RQ+ E L ++ K + + L++EE+ + L +
Sbjct: 1801 EQLRQEREEQQLRPQQRDGK-YRWEEEQLQLEEQEQRLRQ 1839
Score = 106 bits (265), Expect = 5e-23
Identities = 107/479 (22%), Positives = 223/479 (46%), Gaps = 51/479 (10%)
Query: 2 DDFERRRELRRQKREEMRLEA-ERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
++F +LRR++ E+R + E QR + + E + R+ ++EEE L
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKL- 260
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQEALER 117
+ E Q + +EE + Q E +E +RL R ++ R+K+ +E E+
Sbjct: 261 ---QEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317
Query: 118 QKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDW 177
Q+E RR Q + E ++EE+ E + R + E E + Q+ +
Sbjct: 318 QEE--------------RREQQERRE----QQEERREQQLRREQEERREQQLRREQEEER 359
Query: 178 RDAEENKKEDKEKEEEE---EEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEI 234
R+ + +++++E+ E++ E++ +R + + + + + ++L+ ++ +++++
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419
Query: 235 KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 294
+ E+ + ++ +E + ++++ +K + E LK E T R K
Sbjct: 420 RREQQLRREQEEERHEQKHEQERREQRLKREQEE-RRDWLKREEETERHEQERRKQQLKR 478
Query: 295 AEGAPQVEAGKRLEELRRR----------RGETESEEFEKLKQKQQEAALEL-----EEL 339
+ + E +LEE RR R E E ++LK++++E L+ ++L
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538
Query: 340 KKKREERRKVL--EEEEQRRKQEEADRKLREEEEKRR---LKEEIERRRAEAAEKRQKMP 394
++++EERR+ L EEE+R +QE +++L+ E+E+RR LK E ERR+ ++++
Sbjct: 539 RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERL 598
Query: 395 EDGLS-DDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQ 452
E L ++ + + + LK EE E + + KS + Q + + R EQ
Sbjct: 599 EQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Score = 106 bits (265), Expect = 5e-23
Identities = 102/427 (23%), Positives = 204/427 (47%), Gaps = 43/427 (10%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRND-----DDEEEAARE--RRRRARQERLRQK- 53
++ E+RR RR++ +E++ E QR + +EE+ +E RRR++++R QK
Sbjct: 815 EEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874
Query: 54 ----QEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQK 109
+EE + T + Q + E+ +++ ++ E+ R+E+ RQ
Sbjct: 875 RWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER----EKRRRQEQERQY 930
Query: 110 RLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVT 169
R +E L++++E L R + K++K + ++E+ EE E
Sbjct: 931 REEEQLQQEEE--------QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGEN--------QGEEKGTKVQAKREK 221
+ ++ +R+ EE ++E+++ EE EK +R Q EE+ + + ++ +
Sbjct: 983 RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042
Query: 222 LQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTF 281
LQE + +++EE ++ ++ + E + + ++ + + + E +L E
Sbjct: 1043 LQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQE--EEQLLREEPEK 1100
Query: 282 SRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESE--EFEKLKQKQQEAALELEEL 339
R R +E E + E R E +RRR E E + E E+++Q++++ E E
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEK 1160
Query: 340 KKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK----MPE 395
++++E R+ EEEE Q+E ++ LREE+EKRR + E + R E +++++ E
Sbjct: 1161 RRRQELERQYREEEEL---QQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDE 1217
Query: 396 DGLSDDK 402
D SD K
Sbjct: 1218 DQRSDLK 1224
Score = 105 bits (263), Expect = 8e-23
Identities = 93/410 (22%), Positives = 196/410 (47%), Gaps = 34/410 (8%)
Query: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 66
R+ Q+REE R E E++ + + EE E+ RR LR+K EE Q ++
Sbjct: 175 RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234
Query: 67 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT 126
+ Q E K T + E E+L E +RQ+ LQE E+ ++ +
Sbjct: 235 DRVFQEEEEKEWRKRETVLRKEE--------EKLQEEEPQRQRELQEEEEQLRKLERQEL 286
Query: 127 DASLSLPSRRMQNDTAENETTEK--EEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184
++ Q E + K EE+ E ++ER E +E + ++ R +E +
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEER 346
Query: 185 KEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIK-DEKIKKDK 243
+E + + E+EEE+ ++ + Q EE+ + + ++L+ ++ ++++++ ++++++++
Sbjct: 347 REQQLRREQEEERREQ-QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 244 EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT----KEAEGAP 299
+ + E + +++ + + E H+ KH + + R + K E
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE 465
Query: 300 QVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEE--LKKKREERRKVLEEEEQRR 357
+ E +R ++L+R + E E + KL+++++ E E L++++EERR E++ +
Sbjct: 466 RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERR-----EQRLK 520
Query: 358 KQEEADR---KLREEEEKRRLKEE--------IERRRAEAAEKRQKMPED 396
+QEE +R +LR E++ RR +EE E +R E + Q++ +
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE 570
Score = 105 bits (261), Expect = 1e-22
Identities = 101/423 (23%), Positives = 199/423 (47%), Gaps = 35/423 (8%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
ER + RRQ+ + E E++ +R +++ +ER R+ R+E LR +++ +
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQER--EEQPLRRQERDRKFREEELRHQEQGRKFLEEEQ 1381
Query: 65 QV---EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE---RLARREERRQKRLQEALERQ 118
++ E + +++ + Q+ D + F E +L+R+E R+ R +E R+
Sbjct: 1382 RLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETT-EKEEKSESRQERYE--IEETETVTKSYQKN 175
+E + + L R + E + E+EE+ RQER +EE + + + +
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR 1501
Query: 176 DWRDAEENKKEDKEKEEEEEEKPKRGSIGEN-QGEEKGTKVQAKREKLQEDKPTFKKEEI 234
+R+ E +E + K EEE++ R EE+ + Q + ++ ++D+ +EE
Sbjct: 1502 KFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE- 1560
Query: 235 KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV---- 290
E++++++E ++ + DRK E K + E K E R G+ +
Sbjct: 1561 --EQLRQEREEQQLSRQERDRKFRLEEQKVRRQE-QERKFMEDEQQLRRQEGQQQLRQER 1617
Query: 291 DTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVL 350
D K E ++ + + R+ R EE +L+++++E L + +K REE + +
Sbjct: 1618 DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQ 1677
Query: 351 EEEEQRRKQEEADRKLREEEEKRRLKE---------------EIERRRAEAAEKRQKMPE 395
E EEQ+ +++E DRK REEE++ R +E E+ER+ E + RQ+ +
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQ 1737
Query: 396 DGL 398
+ L
Sbjct: 1738 EQL 1740
Score = 103 bits (258), Expect = 3e-22
Identities = 100/460 (21%), Positives = 219/460 (47%), Gaps = 38/460 (8%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDD---DEEEAARERRRRAR-QERLRQKQEEESLG 60
+ +L R++RE+ R + Y++ D+ +EE+ RE R + R QER RQ +EEE L
Sbjct: 998 QEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQ 1057
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFL--ERLARREERRQKRLQEALERQ 118
Q +Q+ + + +E + + +E L E RR + R+++ +E E Q
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQ 1117
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQE-----RYEIEETETVTKSYQ 173
+E + + + + ++ E E ++EE+ R+E R E+E + Q
Sbjct: 1118 QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQ 1177
Query: 174 KND---WRDAEENKKED-----KEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQED 225
+ + R+ +E ++++ +E+EE + +K K+ E+Q + + + ++E D
Sbjct: 1178 QEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRD 1237
Query: 226 KPTFKK-------EEIKDEKIKKDKEPKEEVKSFM-DRKKGFTEVKSQNGEFMTHKLKHT 277
+ K +++D ++ +D++ +++++ + ++++ E + + +
Sbjct: 1238 NKVYCKGRENEQFRQLEDSQL-RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEE 1296
Query: 278 ENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELE 337
E A ++++ Q+ +R E+ RR+ + + E E+L Q+++E L +
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 338 ELKKK--------REERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 389
E +K +E+ RK LEEE++ R+QE +RK +EE++ R +E E++ + ++
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEEQRLRRQER-ERKFLKEEQQLRCQER-EQQLRQDRDR 1414
Query: 390 RQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQ 429
+ + E LS ++ K + + E +FL + Q
Sbjct: 1415 KFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ 1454
Score = 102 bits (254), Expect = 9e-22
Identities = 98/447 (21%), Positives = 207/447 (46%), Gaps = 60/447 (13%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ-VT 63
ERR + R++++E R E +++ ++ + E++ RE+ R+++LR++QEEE Q +
Sbjct: 320 ERREQQERREQQEERRE-QQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR----REERRQKRLQEALERQK 119
+ ++ + + E+ Q+ + + ++L R R E++ +R QE ++
Sbjct: 379 REQQLRREQQLRREQQ--LRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ 436
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQE--RYEIEETETVTKSYQKNDW 177
+ + + L ++ E TE+ E+ +Q+ R + EE ++ +
Sbjct: 437 KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496
Query: 178 RDAEENKKED--KEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIK 235
R+ +E +++ +E+EE E++ KR E + ++ Q +RE+ + + K+EE K
Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556
Query: 236 -------DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTE----NTFSRP 284
++++K+++E + + + ++ +K + E + +LK E R
Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERR 616
Query: 285 GGRASVDTKEAEGAPQVEAGKRLEELRRR--RGETESEEFEKLKQKQQEAALELEELKKK 342
R + E E Q+ + EE R++ R E + ++LK++++E LE + LK++
Sbjct: 617 EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE-QRLKRE 675
Query: 343 REERRKVLE--EEEQR--------------------------------RKQEEADRKLRE 368
EE R+ E EEEQ RKQE R+ +
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQ 735
Query: 369 EEEKRRLKEEIERRRAEAAEKRQKMPE 395
EE++RR + E++ + E A ++Q+ E
Sbjct: 736 EEKRRRRESELQWQEEERAHRQQQEEE 762
Score = 100 bits (249), Expect = 4e-21
Identities = 105/438 (23%), Positives = 208/438 (47%), Gaps = 58/438 (13%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQER----LRQKQEEESLG 60
E RRE +R KREE E ER +++EE +++ RR +QER L++++EEE L
Sbjct: 613 EERRE-QRLKREEP--EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE 669
Query: 61 Q--VTDQVEVNAQNSVPDEE---------AKTTTTNTQVEGDDEAAFLERLAR-REERRQ 108
Q + E + + +EE ++ Q+E + +A + +R R++ Q
Sbjct: 670 QRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQ 729
Query: 109 KRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETT---EKEEKSESRQERYEIEET 165
+R QE E+++ + + R+ Q + + T + EEKSE ++R
Sbjct: 730 RRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRL---SA 786
Query: 166 ETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQED 225
+ ++ R E ++E + EEEE++ +R + + EK + + E+LQ
Sbjct: 787 RPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR---RQRREREKELQFLEEEEQLQRR 843
Query: 226 KPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPG 285
+ + +E +++ +++D+E + + D+K + + + +++P
Sbjct: 844 ERAQQLQE-EEDGLQEDQERRRSQEQRRDQK--------WRWQLEEERKRRRHTLYAKPA 894
Query: 286 GRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE 345
+ + ++ + E +R E +RRR E E + E+ + +Q+E L EE +K+R +
Sbjct: 895 LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ 954
Query: 346 RR---------------KVLEEEEQRRKQEEADRKLREE-----EEKRRLKEEIERRRAE 385
R ++L EE ++R+++E ++K REE EE++ L+EE E+RR +
Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014
Query: 386 AAEKRQKMPEDGLSDDKK 403
E RQ +D L +++
Sbjct: 1015 EWE-RQYRKKDELQQEEE 1031
Score = 100 bits (248), Expect = 5e-21
Identities = 91/408 (22%), Positives = 188/408 (46%), Gaps = 54/408 (13%)
Query: 2 DDFERRR--ELRRQKREEMRLEAERIAYQRN-------------------DDDEEEAARE 40
+D ERRR E RR ++ +LE ER + +++EE E
Sbjct: 858 EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE 917
Query: 41 RRRRARQERLRQKQEEESLGQVTDQV--EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE 98
R +R RQE+ RQ +EEE L Q +Q+ E + + E + + +++ E
Sbjct: 918 REKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE 977
Query: 99 RLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQE 158
RR + R+K+ +E E Q+E + + + + + + + ++EE+ R+E
Sbjct: 978 PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037
Query: 159 RYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAK 218
R + E ++ +R+ EE ++E+++ EE E +R + +E+ ++Q +
Sbjct: 1038 REKRRLQE------RERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE--ELQQE 1089
Query: 219 REKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTE 278
E+L ++P ++ + ++ + ++++E ++E + + ++ + ++
Sbjct: 1090 EEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQY--------- 1140
Query: 279 NTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEE 338
+E E + E R E +RRR E E + E+ + +Q+E L EE
Sbjct: 1141 -------------REEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREE 1187
Query: 339 LKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEA 386
+K+R+ER + EEE+ ++Q+ R R+E+++ LK + E + A
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQR-YRDEDQRSDLKWQWEPEKENA 1234
Score = 100 bits (248), Expect = 5e-21
Identities = 107/417 (25%), Positives = 192/417 (46%), Gaps = 65/417 (15%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQ 65
RR+E RQ REE L+ E +E+ ER +R RQE RQ +EEE + Q +Q
Sbjct: 1102 RRQERERQCREEEELQQE---------EEQLLREEREKRRRQELERQYREEEEVQQEEEQ 1152
Query: 66 VEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFL--ERLARREER-RQKRLQEALERQK--- 119
+ +E + + +E L E+ RR+ER RQ R +E L+RQK
Sbjct: 1153 LLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQ 1212
Query: 120 -------------EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE--SRQERYEIE- 163
+++P +A + ++ ENE + E S+ RQ + +++
Sbjct: 1213 RYRDEDQRSDLKWQWEPEKENA---VRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQH 1269
Query: 164 ---ETETVTKSYQKNDWRDAEENKKEDKEKE-EEEEEKPKRGSIGENQGEEKGTKVQAKR 219
E + + ++ W+ + + E+++ E EE++E +R
Sbjct: 1270 LLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD------------------ 1311
Query: 220 EKLQEDKPTFKKE-EIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTE 278
K QE+K ++E E K + + D++ +EE + +R++ + ++ +F +L+H E
Sbjct: 1312 RKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQE 1371
Query: 279 N-----TFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAA 333
+ R + K + Q+ +R ++LR+ R EE ++L +++++
Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431
Query: 334 LELEELKKKREER-RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 389
EE + +R+ER RK LEEE+Q R +E RK REEE+ + +EE + R E K
Sbjct: 1432 FREEEQQVRRQERERKFLEEEQQLR--QERHRKFREEEQLLQEREEQQLHRQERDRK 1486
Score = 99.8 bits (247), Expect = 6e-21
Identities = 92/400 (23%), Positives = 189/400 (47%), Gaps = 28/400 (7%)
Query: 6 RRRELRRQKREEMRLEAERIAY----QRNDDDEEEAAR--ERRRRARQERLRQKQEEESL 59
R +ELR Q+ E LE E+ + QR EE+ R ER ++ RQ+R R+ +EEE L
Sbjct: 1504 REQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL 1563
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
Q ++ +++ Q D + + + + + + R + Q++L++ +R+
Sbjct: 1564 RQEREEQQLSRQER--DRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF 1621
Query: 120 EFDPTITDASLSLPSRRMQNDTA---ENETTEKEEKSES---------RQERYEIEETET 167
D + R + D E ++E+ + R+E ++E E
Sbjct: 1622 REDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE 1681
Query: 168 VTKSYQKNDWRDAEENKKEDKEKEE----EEEEKPKRGSIGENQGEEKGTKVQAKREKLQ 223
Q+ D + EE ++ +++ E +EE++ +R + EE+ + + ++E+L+
Sbjct: 1682 QQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLR 1741
Query: 224 EDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSR 283
+ ++ +++E+++ ++E ++ + DRK E Q E + + ++ F R
Sbjct: 1742 RQERY--RKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKF-R 1798
Query: 284 PGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR 343
+ + +E + PQ GK E + + E + + + + +Q A + +K R
Sbjct: 1799 EEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSR 1858
Query: 344 EERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR 383
E +++ +EEEQ+R+QE +RKLREE +R+ KEE R+
Sbjct: 1859 REEQELWQEEEQKRRQER-ERKLREEHIRRQQKEEQRHRQ 1897
Score = 98.6 bits (244), Expect = 1e-20
Identities = 92/404 (22%), Positives = 185/404 (45%), Gaps = 28/404 (6%)
Query: 5 ERRRELRRQKRE------EMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES 58
E + LRRQ+RE E +L + Q D + + E ++ +RQER R+ +EEE
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
QV + EE + + +E L+ ++ RQ+R ++ LE +
Sbjct: 1438 ------QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEE 1491
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET--VTKSYQKND 176
++ D R Q + E++ + RQ ++ EE + + Q+
Sbjct: 1492 QQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQ 1551
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKD 236
RD + ++E +E EE++ ++ + + EE+ + Q + K ED+ +++E +
Sbjct: 1552 DRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQ 1611
Query: 237 E-KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHK--LKHTENTFSRPGGRASVDTK 293
+ + ++D++ +E+ + +R++ + ++ +F+ + L+ E R D K
Sbjct: 1612 QLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDR---DRK 1668
Query: 294 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 353
E ++ G+ + R+ R EE ++L+++++E EE + +R+E + EE
Sbjct: 1669 FREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREE 1728
Query: 354 EQRRKQEEAD--------RKLREEEEKRRLKEEIERRRAEAAEK 389
EQ R++ E + RK+ EEE+ R +EE + RR E K
Sbjct: 1729 EQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRK 1772
Score = 97.4 bits (241), Expect = 3e-20
Identities = 91/429 (21%), Positives = 203/429 (47%), Gaps = 52/429 (12%)
Query: 1 MDDFERRR-ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLR-------- 51
+D+ +R R + + ++ R E ++ ++ D EE +RRR+ RQE+ R
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 52 -QKQE----------EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF---- 96
+KQE +E L + + + + +E+ ++ + E DE
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 97 ---LERLARREERRQKRLQE--ALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE 151
L R R E+++Q+R ++ + ++E + + L ++Q + + + +EE
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE 274
Query: 152 KSESRQ-ERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEE 210
+ + R+ ER E+ + Q+ R+ + +K+++E+ E++EE+ ++ E Q E
Sbjct: 275 EEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEER 334
Query: 211 KGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFM 270
+ +++ ++E+ +E + ++EE + E+ + ++ +E + + R++
Sbjct: 335 REQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ------------- 381
Query: 271 THKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQ 330
+L+ + R + + + + +R ++LRR + +E E+ +QK +
Sbjct: 382 --QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439
Query: 331 EAALELEELKKKREERRKVLEEEEQRRKQEEADRK---LREEEEKRR---LKEEIERRRA 384
+ E + LK+++EERR L+ EE+ + E+ RK R++EE+RR LK E E RR
Sbjct: 440 QERRE-QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498
Query: 385 EAAEKRQKM 393
+ + Q++
Sbjct: 499 QQERREQQL 507
Score = 92.8 bits (229), Expect = 7e-19
Identities = 99/449 (22%), Positives = 205/449 (45%), Gaps = 63/449 (14%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRA-------RQERLRQKQEEE 57
E RR+ R ++ +E RLE +R+ + + E+E RE+R + RQ+ L+ +++EE
Sbjct: 583 EERRQQRLKREQEERLE-QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641
Query: 58 SLGQVT--DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEAL 115
Q +Q E Q +EE + + E ++E E +E+ ++R++ +
Sbjct: 642 RRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRI 701
Query: 116 ERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKN 175
+ + + DA S R + + E+EEK R+ + +E E + Q+
Sbjct: 702 PKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE 761
Query: 176 DWR-------DAEENK-------------KEDKEKEEEEEEKPKRGSIGENQGEEKGTKV 215
+ R AEE +E +E++ EE+ +R + EEK +
Sbjct: 762 EQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR 821
Query: 216 QAKREKLQEDKPTFKKEEI-KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTH-- 272
+ +RE+ +E + ++E++ + E+ ++ +E ++ ++ +R++ + + Q +
Sbjct: 822 RQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEE 881
Query: 273 KLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEA 332
+ + +++P + + ++ + E +R E +RRR E E + E+ + +Q+E
Sbjct: 882 RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEE 941
Query: 333 ALELEELKKKR--------------------------EERRKVLEEEEQRRK---QEEAD 363
L EE +K+R E+RR+ E++ R + Q+E +
Sbjct: 942 QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001
Query: 364 RKLREEEEKRRLKEEIERRRAEAAEKRQK 392
+ LREE EKRR ++E ER+ + E +Q+
Sbjct: 1002 QLLREEREKRR-RQEWERQYRKKDELQQE 1029
Score = 89.4 bits (220), Expect = 8e-18
Identities = 80/373 (21%), Positives = 175/373 (46%), Gaps = 18/373 (4%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
+ R + RRQ R+ E E++ +R + R+R+ R ++++R++++E +
Sbjct: 1543 QERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQ 1602
Query: 65 QVE-VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEA--LERQKEF 121
Q+ Q + E + + Q+ + E E+ R+ER +K L+E L RQ+
Sbjct: 1603 QLRRQEGQQQLRQERDRKFREDEQLLQERE----EQQLHRQERDRKFLEEEPQLRRQERE 1658
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
D + + E E++ + + R ++ EE + + ++ ++ +
Sbjct: 1659 QQLRHDRDRKF----REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQ 1714
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKK 241
+ ++++ E++ EEE+ + + +E+ + + R+ L+E++ ++EE + + ++
Sbjct: 1715 QLRRQELERKFREEEQ-----LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQER 1769
Query: 242 DKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKL--KHTENTFSRPGGRASVDTKEAEGAP 299
D++ +EE + +R++ + + +F + + E RP R E E
Sbjct: 1770 DRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQ 1829
Query: 300 QVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQ 359
E +RL + R R+ E + + K +++E L EE +K+R+ER + L EE RR+Q
Sbjct: 1830 LEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQ 1889
Query: 360 EEADRKLREEEEK 372
+E R + E K
Sbjct: 1890 KEEQRHRQVGEIK 1902
Score = 67.0 bits (162), Expect = 4e-11
Identities = 57/230 (24%), Positives = 117/230 (50%), Gaps = 17/230 (7%)
Query: 179 DAEENKKEDKEKEEEEEE-KPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE 237
D +E+ +D+ +EE++ +P+ + E G+ + K Q + +L E + +K+E ++
Sbjct: 104 DGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQ 163
Query: 238 KIKKDKEP-----KEEVKSFMDRKKGFTEVKSQNG----EFMTHK-LKHTENTFSRPGGR 287
+ ++ ++ ++E + +R+ +++S G EF + L+ E R GR
Sbjct: 164 RDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGR 223
Query: 288 ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR 347
+ E +V + +E R+R EE EKL++++ + EL+E + E+ R
Sbjct: 224 EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEE-EKLQEEEPQRQRELQE---EEEQLR 279
Query: 348 KVLEEEEQRRKQEE--ADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 395
K+ +E +R +QEE ++LR E++ RR +EE R + E ++Q+ E
Sbjct: 280 KLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE 329
Score = 56.2 bits (134), Expect = 8e-08
Identities = 52/266 (19%), Positives = 116/266 (43%), Gaps = 16/266 (6%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
ER ++LR + + R E E++ + + R+R+ R +++LR+++ E Q
Sbjct: 1656 EREQQLRHDRDRKFR-EEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQ 1714
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Q+ EE + Q + RR+ER +K L+E R + +
Sbjct: 1715 QLRRQELERKFREEEQLRQETEQEQ-----------LRRQERYRKILEEEQLRPEREEQQ 1763
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184
+ R + E E + + R+ R E + + + + RD +
Sbjct: 1764 LRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRW 1823
Query: 185 KEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQE--DKPTFKKEEIKDEKIKKD 242
+E++ + EE+E++ ++ + + EE+ + R + QE + K+ + ++ K++++
Sbjct: 1824 EEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREE 1883
Query: 243 KEPKEEVKSFMDRKKGFTEVKSQNGE 268
+++ + R+ G E+KSQ G+
Sbjct: 1884 HIRRQQKEEQRHRQVG--EIKSQEGK 1907
Score = 53.1 bits (126), Expect = 6e-07
Identities = 44/181 (24%), Positives = 89/181 (49%), Gaps = 19/181 (10%)
Query: 237 EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAE 296
E + +D+ +E+ + F R + +++ + G+ K + E + +++ E
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDR---QLEEEPGQRRRQKRQEQERELAE----GEEQSEKQE 159
Query: 297 GAPQVEAGKRLEELRRRRGE--------TESEEFEKLKQKQQEAALELEELKKKR--EER 346
Q + +R EEL R+R E E E+ + K + E + E+L+++ E R
Sbjct: 160 RLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELR 219
Query: 347 RKVLEEEEQRRKQEEADRKLREEEEKR-RLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF 405
RK EE++Q+R+ E DR +EEEEK R +E + R+ E ++ + + L ++++
Sbjct: 220 RKGREEKQQQRR-ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL 278
Query: 406 K 406
+
Sbjct: 279 R 279
Score = 47.8 bits (112), Expect = 3e-05
Identities = 39/168 (23%), Positives = 87/168 (51%), Gaps = 7/168 (4%)
Query: 287 RASVDTKEA--EGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 344
RA D KE+ + Q E +R E R + E E ++ +QK+QE EL E +++
Sbjct: 100 RARCDGKESLLQDRRQEEDQRRFEPRDR---QLEEEPGQRRRQKRQEQERELAE-GEEQS 155
Query: 345 ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKP 404
E+++ LE+ +++R+ EE R+ +E +E+ + E E+ ++ + ++ P++ ++
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 405 FKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQ 452
+ KG K ++R E ++ Q+ + + ++ K + +L++
Sbjct: 216 LE-LRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE 262
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 110 bits (276), Expect = 3e-24
Identities = 105/430 (24%), Positives = 207/430 (48%), Gaps = 24/430 (5%)
Query: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAA---RERRRRARQERLRQKQEE-ESLGQV 62
+ E R++ E+M + ER+ Q E+E +E R + ERLR+K+E ++
Sbjct: 360 QEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKM 419
Query: 63 TDQVE-VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE- 120
+QVE + + + ++E KT +++ ++ E+ R EE + +E +++Q+E
Sbjct: 420 WEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEEN 479
Query: 121 -FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
++ + + + + + E+EEK ++E+ +E +K WR
Sbjct: 480 MWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW---GQEKKMWRQ 536
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQGE-EKGTKVQAKREKLQEDKPTFKKEEIKDEK 238
+ ++ED+ E+EE+ + + + + + EK T+ Q K+ QE+K ++EE E+
Sbjct: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEK--MREEERMRER 594
Query: 239 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRA-SVDTKEAEG 297
KK +E +EE+ + K E K Q E K+ E + + K E
Sbjct: 595 EKKMRE-EEEMMREQEEKMQEQEEKMQEQE---EKMWEQEEKMQEQEEKMWEQEEKMWEQ 650
Query: 298 APQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRR 357
++ +RL E + + E E + ++ Q+Q+E E E+++KK +E+ K ++E+ R
Sbjct: 651 EEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710
Query: 358 KQE---EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSS 414
++E E ++K+REEEE R +EE + E EK Q+ E+ ++K ++
Sbjct: 711 EEESMREREKKMREEEEMMREQEE---KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQ 767
Query: 415 LKIEERAEFL 424
++ E+ E L
Sbjct: 768 QRLPEQKEKL 777
Score = 109 bits (273), Expect = 6e-24
Identities = 110/402 (27%), Positives = 195/402 (48%), Gaps = 26/402 (6%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRND--DDEEEAARERRRRARQERLRQKQEEESLGQV 62
E+ +++R+Q+ E+M + ER+ Q + EE+ R+ +R QE+ ++QE+E +
Sbjct: 283 EQEKKIRKQE-EKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKE----L 337
Query: 63 TDQVEVNAQ-NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+Q E+ Q + ++E K ++ +E + + E+ +Q R QE R +E
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEK--EEKSESRQERYEIEETETVTKSYQKNDWRD 179
D L RM+ E EK EEK QE+ ++ E K ++ R+
Sbjct: 398 RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEE---KMQEEERIRE 454
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQ---AKREKLQEDKPTFKKEE--- 233
E+ +E++E E+EEK ++ + EEK + Q ++EKL E + ++EE
Sbjct: 455 REKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIW 514
Query: 234 IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTK 293
++EKI+ +E + K M R++ E + Q E K++ E R T+
Sbjct: 515 EQEEKIRDQEEMWGQEKK-MWRQEKMREQEDQMWE-QEEKMRDQEQKMWDQEERMEKKTQ 572
Query: 294 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 353
E E + K EE R R E + E E++ ++Q+E E EE K +E+ K+ E+E
Sbjct: 573 EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEE--KMQEQEEKMWEQE 630
Query: 354 EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 395
E+ ++QEE K+ E+EEK +EE + E+++K+ E
Sbjct: 631 EKMQEQEE---KMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 669
Score = 93.6 bits (231), Expect = 4e-19
Identities = 93/424 (21%), Positives = 199/424 (46%), Gaps = 46/424 (10%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQE-RLRQKQ-----E 55
D+ R +E R +++E+M + E++ ++ ++E+ R++ + ++E R+R+++ E
Sbjct: 403 DERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE 462
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER--RQKRLQE 113
EE++ + ++++ +N EE + +RL ++E+ Q+++QE
Sbjct: 463 EETMREQEEKMQKQEENMWEQEEKEWQQ--------------QRLPEQKEKLWEQEKMQE 508
Query: 114 ALERQKEFDPTITDASLSLPS-----RRMQNDTAENETTEKEEKSESRQERY--EIEETE 166
E+ E + I D R+ + E++ E+EEK ++++ + E E
Sbjct: 509 QEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERME 568
Query: 167 TVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDK 226
T+ +K W E+ ++E++ +E E++ + + E E+ K+Q + EK+QE +
Sbjct: 569 KKTQEQEKKTWDQEEKMREEERMREREKKMREE-----EEMMREQEEKMQEQEEKMQEQE 623
Query: 227 PTFKKEEIK----DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFS 282
++E K +EK+ + +E E + M ++ E K + E K++ E
Sbjct: 624 EKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH--EKMQEQEKMQE 681
Query: 283 RPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKK 342
+ + +E E K+ + + R E E EK ++++E E EE ++
Sbjct: 682 Q---EEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQE 738
Query: 343 REERRKVLEEE--EQRRKQEEADRKLREEEEKRRLKEEI-ERRRAEAAEKRQKMPEDGLS 399
+EE+ + EEE EQ K E + K+ E++ KE++ E + + EK + E
Sbjct: 739 QEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRD 798
Query: 400 DDKK 403
++K
Sbjct: 799 QEEK 802
Score = 92.0 bits (227), Expect = 1e-18
Identities = 93/406 (22%), Positives = 197/406 (48%), Gaps = 43/406 (10%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
M + E++ + +K +E ER R +++ E+ ++ + Q+++E
Sbjct: 432 MQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 491
Query: 61 QVTDQVE-VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER---RQKRLQEALE 116
++ +Q E + Q + ++E K ++ +E E+ R+E+ ++ ++ E E
Sbjct: 492 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
+ ++ + + D Q + E +T E+E+K+ ++E+ EE ++
Sbjct: 552 KMRDQEQKMWD----------QEERMEKKTQEQEKKTWDQEEKMREEE----RMREREKK 597
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKL--QEDKPTFKKEEI 234
R+ EE +E +EK +E+EEK + E + E+ K+Q + EK+ QE+K ++E++
Sbjct: 598 MREEEEMMREQEEKMQEQEEKMQE---QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKM 654
Query: 235 -KDEKIKKDKEPKEEVKSFMDRKK-GFTEVKSQNGEFMTHKLKHTE-NTFSRPGGRASVD 291
+ +++ + KE E + +++K E K E M K + E T+ + R
Sbjct: 655 WEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEES 714
Query: 292 TKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE------- 344
+E E + E EE+ R + E E+ EK++++++E + E++ ++ E
Sbjct: 715 MREREKKMREE-----EEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQR 769
Query: 345 --ERRKVLEEEEQRRKQE---EADRKLREEEEKRRLKEEIERRRAE 385
E+++ L E E+ ++QE E + K+R++EEK R +EE R + E
Sbjct: 770 LPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEE 815
Score = 90.5 bits (223), Expect = 4e-18
Identities = 98/417 (23%), Positives = 200/417 (47%), Gaps = 49/417 (11%)
Query: 4 FERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ-- 61
+E+ ++R +K+ M+ + ++ Q EEE RER ++ R+E +++EE + +
Sbjct: 420 WEQVEKMREEKK--MQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE 477
Query: 62 --VTDQVEVN-AQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER---------RQK 109
+ +Q E Q +P+++ K E +++ E R +E RQ+
Sbjct: 478 ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE 537
Query: 110 RLQEALERQKEFDPTITDASLSL--PSRRMQNDTAENE--TTEKEEKSESRQ-----ERY 160
+++E ++ E + + D + RM+ T E E T ++EEK + E+
Sbjct: 538 KMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKK 597
Query: 161 EIEETETVTKSYQKNDWRDAEENKKEDK--EKEEEEEEKPKRGSIGEN---QGEEK---G 212
EE E + + +K ++ + ++E+K E+EE+ +E+ ++ E + EEK
Sbjct: 598 MREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQ 657
Query: 213 TKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTH 272
++ ++EKL E + ++E++++++ K ++ K E K+ KK + + K + E M
Sbjct: 658 QRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRE 717
Query: 273 KLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQ--KQQ 330
+ K R + + E ++++E E E + +E+ ++ +QQ
Sbjct: 718 REKKM---------REEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ 768
Query: 331 EAALELEEL--KKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE 385
+ E+L +K +E+ K+ E+EE+ R QEE K+R +EEK R +EE R + E
Sbjct: 769 RLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEE---KMRGQEEKMRGQEEKMRGQEE 822
Score = 87.8 bits (216), Expect = 2e-17
Identities = 86/387 (22%), Positives = 180/387 (46%), Gaps = 56/387 (14%)
Query: 4 FERRRELRRQKR----EEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
+E+ ++R Q++ +E R+E + ++ D+EE RE R +E+ + ++EEE +
Sbjct: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK-KMREEEEMM 605
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
+ ++++ + + ++E K +++ +E + + E+ + Q+ L QK
Sbjct: 606 REQEEKMQ-EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQK 664
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQER-YEIEETETVTKSYQKNDWR 178
E E+E +++EK + ++E+ +E E+ E T+ +K W
Sbjct: 665 E-------------------KLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW- 704
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEK 238
D E+ ++E+ +E E++ + + E E+ K+Q + EK+QE + ++E EK
Sbjct: 705 DQEKMREEESMREREKKMREE-----EEMMREQEEKMQEQEEKMQEQEEEMWEQE---EK 756
Query: 239 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGA 298
+ + +E E + ++K+ E + K++ E + + E +
Sbjct: 757 MWEQEEKMWEQQRLPEQKEKLWEHE---------KMQEQEKIWEQ----------EEKMR 797
Query: 299 PQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRK 358
Q E + EE + RG+ E ++ K QE + +E K +E + +EE+ K
Sbjct: 798 DQEEKMRGQEE--KMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEK 855
Query: 359 QEEADRKLREEEEKRRLKEEIERRRAE 385
+ + K+RE+EEK R +EE R + E
Sbjct: 856 MQGQEEKMREQEEKMRGQEEKMREQEE 882
Score = 86.7 bits (213), Expect = 5e-17
Identities = 99/438 (22%), Positives = 200/438 (45%), Gaps = 37/438 (8%)
Query: 1 MDDFERRRELRRQKREE---MRLEAERIAYQRND--DDEEEAARERRRRARQERL-RQKQ 54
M + ER RE ++ REE MR + E++ Q + + EE+ +++R ++E+L Q++
Sbjct: 446 MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK 505
Query: 55 EEESLGQVTDQVE-VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQE 113
+E ++ +Q E + Q + +E K E +D+ E R +E++ +E
Sbjct: 506 MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEE 565
Query: 114 ALERQ-KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSY 172
+E++ +E + D + R + E E +EE+ R++ +++E E +
Sbjct: 566 RMEKKTQEQEKKTWDQEEKM---REEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 622
Query: 173 QKNDWRDAEENKKEDKEKEEEEEEK---------------PKRGSIGENQGEEKGTKVQA 217
++ W + EE +E +EK E+EEK ++ + E++ ++ K+Q
Sbjct: 623 EEKMW-EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681
Query: 218 KREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHT 277
+ EK+ E + KK + + EK D+E E +S +R+K E + E +
Sbjct: 682 QEEKIWEQEKMEKKTQ-EQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQE 740
Query: 278 ENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETES-EEFEKL-----KQKQQE 331
E + + K E ++ +RL E + + E E +E EK+ K + QE
Sbjct: 741 EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQE 800
Query: 332 AALELEELKKK-REERRKVLEEE--EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAE 388
+ +E K + +EE+ + EE+ Q K + K+ +EEK +EE + + E
Sbjct: 801 EKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQE 860
Query: 389 KRQKMPEDGLSDDKKPFK 406
++ + E+ + ++ +
Sbjct: 861 EKMREQEEKMRGQEEKMR 878
Score = 85.9 bits (211), Expect = 9e-17
Identities = 77/364 (21%), Positives = 167/364 (45%), Gaps = 45/364 (12%)
Query: 38 ARERRRRARQERLRQKQEEESLGQVTDQVEVNA----QNSVPDEEAKTTTTNTQVEGDDE 93
A E +R R K+ + + ++T + + + +N++ +EE K Q ++
Sbjct: 178 AGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQ----EK 233
Query: 94 AAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKS 153
E + K L+ LER K P + +L R + + E E ++++
Sbjct: 234 LPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
Query: 154 ESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI--GENQGEEK 211
+ ++ + E E + ++ WR + ++++KE E+E+E ++ + E Q +E+
Sbjct: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQ 353
Query: 212 GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMT 271
K+ + EK++E + ++E + +++K+ +E+ + D+++ E
Sbjct: 354 EEKMWEQEEKMREQEEKMWRQE--ERLWEQEKQMREQEQKMRDQEERMWE--------QD 403
Query: 272 HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQE 331
+L+ E E K E++ + R E + +E EK + Q+E
Sbjct: 404 ERLREKEERMR-------------------EQEKMWEQVEKMREEKKMQEQEKKTRDQEE 444
Query: 332 AALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQ 391
+++E ++ RE +K+ EEEE R+QEE K++++EE +EE E ++ E+++
Sbjct: 445 ---KMQEEERIREREKKMREEEETMREQEE---KMQKQEENMWEQEEKEWQQQRLPEQKE 498
Query: 392 KMPE 395
K+ E
Sbjct: 499 KLWE 502
Score = 60.8 bits (146), Expect = 3e-09
Identities = 59/284 (20%), Positives = 133/284 (46%), Gaps = 21/284 (7%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRND----------DDEEEAARERRRRARQERLR 51
++ R +E + Q++EE E E +++ + + EE+ + + Q+RL
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
Query: 52 QKQE---EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQ 108
+++E E Q ++++ + E+ + T + + D+ E + RE R+
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRE--RE 719
Query: 109 KRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETV 168
K+++E E +E + + + + + + E + E+EEK +Q E +E
Sbjct: 720 KKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 779
Query: 169 TKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKL--QEDK 226
+ Q+ + +E K D+E++ +E+ RG + +G+E+ K+ + EK+ QE+K
Sbjct: 780 HEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEE--KMWGQEEKMWGQEEK 837
Query: 227 PTFKKEEI--KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGE 268
++E++ ++EK+++ + +EE + K E K + E
Sbjct: 838 MWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQE 881
Score = 55.1 bits (131), Expect = 2e-07
Identities = 59/272 (21%), Positives = 125/272 (45%), Gaps = 37/272 (13%)
Query: 156 RQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKV 215
+ +RY IEE + +R+ N++ K+ E +E+ P + E++ E V
Sbjct: 194 KADRY-IEELTKERDALSLELYRNTITNEELKKKNAELQEKLP----LAESEKSEIQLNV 248
Query: 216 QAKREKLQEDK---PTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTH 272
+ + KL+ K P + +++E ++++E +E+ K +++ + + E
Sbjct: 249 KELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLRE-QEG 307
Query: 273 KLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEA 332
K++ E R KRL E + E E E E+ + ++QE
Sbjct: 308 KMREQEEKMWRQE-------------------KRLREQEKELREQEKELREQKELREQEE 348
Query: 333 ALELEELKKKREERRKVLEEEEQRRKQE----EADRKLREEEEKRRLKEEIERRRAEAAE 388
++ +E +K E+ K+ E+EE+ +QE E ++++RE+E+K R +EE R +
Sbjct: 349 QMQEQE-EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE----RMWEQD 403
Query: 389 KRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER 420
+R + E+ + + +K ++ K++E+
Sbjct: 404 ERLREKEERMREQEKMWEQVEKMREEKKMQEQ 435
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 109 bits (272), Expect = 8e-24
Identities = 98/398 (24%), Positives = 180/398 (45%), Gaps = 34/398 (8%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
DD ER R+ R++R E R +R E++ R+R R ++R R+K+ E +
Sbjct: 52 DDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDR 111
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
D+ +N + E +T + G D + +RE RQ+ ++ ERQ +
Sbjct: 112 ERDRQREKERNRQKERERETEREGER--GRDR----QTDGQRERERQRDAEKERERQTD- 164
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
R Q T N E+E + ++RQER E E + K + R +E
Sbjct: 165 -------------RERQRQTERNRQKERE-REKNRQER---RERERQREKENKTEDRHSE 207
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQGE---EKGTKVQAKREKLQEDKPTFKKEEIKDEK 238
++ ++E+E E E + KR + E + E+ + QA+RE+ E + KE ++
Sbjct: 208 RGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERD 267
Query: 239 IKKDKEPKEEVKSFM-DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEG 297
+D++ +++ + DRK+ + + E + + E R R +E E
Sbjct: 268 RDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERER 327
Query: 298 APQ--VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELE-ELKKKREERRKVLEEEE 354
Q E + E R+R+ +TE + E+ +Q +E + E E +++RE R+ E E
Sbjct: 328 ERQRETERDREKERERKRKRQTEMDR-ERNRQTGREGRRQAERERERERERDRQSARERE 386
Query: 355 QRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 392
+R + + DR ++E E++ K+ +R E +R+K
Sbjct: 387 ERERDRDRDR--QKERERQTEKDRDGQRETEKQREREK 422
Score = 103 bits (256), Expect = 5e-22
Identities = 87/394 (22%), Positives = 173/394 (43%), Gaps = 30/394 (7%)
Query: 5 ERRRELRRQKREEMRLEAERIAY---QRNDDDEEEAARERRRRARQERLRQKQEEESLG- 60
ERRRE R ++ + E +R +R D E + RE+ R ++ER R+ + E G
Sbjct: 80 ERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGR 139
Query: 61 --QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALER- 117
Q Q E Q E + T Q + ER ++E R+K QE ER
Sbjct: 140 DRQTDGQRERERQRDAEKERERQTDRERQRQ-------TERNRQKEREREKNRQERRERE 192
Query: 118 -QKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESR-------QERYEIEETETVT 169
Q+E + D R + E ET K + R +ER + E E +
Sbjct: 193 RQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERAS 252
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTF 229
+ + D ++ E + D++++ ++E+ ++ + E+ + + KRE+ +E +
Sbjct: 253 ERETERD-KERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERER 311
Query: 230 KKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS 289
++ ++ + ++++E + + ++ DR+K + + E + + T R G R +
Sbjct: 312 ERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQT----GREGRRQA 367
Query: 290 VDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 349
+E E ++ + EE R R +E E+ +K ++ E E+ +++ ++R
Sbjct: 368 ERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRE-- 425
Query: 350 LEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR 383
E + R +E +K RE + +R+ + R+R
Sbjct: 426 -SERGRERGREREKQKGRERDRERQTDRQAGRQR 458
Score = 99.0 bits (245), Expect = 1e-20
Identities = 118/530 (22%), Positives = 214/530 (40%), Gaps = 55/530 (10%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQE---------RLRQK 53
DF RRR +E R A++ D D+ E R++ R R+E R R++
Sbjct: 25 DFSRRRP---GSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRER 81
Query: 54 QEEESLGQVTDQVEVNAQNSVPDEEAKT---------TTTNTQVEGDDEAAFLERLARRE 104
+ E+ + D+ ++ + E +T N Q E + E ER R
Sbjct: 82 RREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERET---EREGERG 138
Query: 105 ERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQE--RYEI 162
RQ Q ERQ++ + R Q D TE+ + E +E R E
Sbjct: 139 RDRQTDGQRERERQRDAE----------KERERQTDRERQRQTERNRQKEREREKNRQER 188
Query: 163 EETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKL 222
E E + K + R +E ++ ++E+E E E + KR + ++ ++ K + +REK
Sbjct: 189 RERERQREKENKTEDRHSERGRERERERETETETERKRQT---DRERDRQRKTEREREKQ 245
Query: 223 QEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFS 282
E +E + + ++DKE + E DR + E + Q + + T
Sbjct: 246 AE------RERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRET-E 298
Query: 283 RPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKK 342
R R +E E + E + E R R+ ETE + EK ++++++ E++ + +
Sbjct: 299 RKRERQRERERERERNRKRERERERERERERQRETERDR-EKERERKRKRQTEMDRERNR 357
Query: 343 REERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 402
+ R + E +R ++ E DR+ E E+R + + +R R + E++ + DG + +
Sbjct: 358 QTGREGRRQAERERERERERDRQSAREREER--ERDRDRDRQKERERQTEKDRDGQRETE 415
Query: 403 KPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKS 462
K + + S ER + +K G + + + + ++ T +
Sbjct: 416 KQREREKDRES-----ERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPR 470
Query: 463 AKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVG 512
+ SD P G+R KS E S+ G P K + G G
Sbjct: 471 TARSGVVQSDPNRPTRGIR-WKSSPEDPKAASTRFPWGRPAKASRGRVAG 519
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 108 bits (270), Expect = 1e-23
Identities = 91/410 (22%), Positives = 195/410 (47%), Gaps = 30/410 (7%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIA-YQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
+++ E L +Q+ E+M + E+I ++ ++EE RE+ + R++ + +++EE +
Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM 344
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
+ +++ + EE E +++ E + +E + + L+E + Q+
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 404
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
+ +R + + + +E++++ ++ +I E E + +K WR
Sbjct: 405 KIREQ--------EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ 456
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIK---- 235
E+ +++K +EEE+ ++ + E + E+ ++ ++EK+ E + +K+E K
Sbjct: 457 EEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQ-EEIWRQKEKMHEQEEKIRKQEEKVWRQ 515
Query: 236 DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTK-- 293
+EKI++ +E E + M R++ +++ Q + + H + R + K
Sbjct: 516 EEKIREQEEKIREQEEKMWRQE--EKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMW 573
Query: 294 --EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEEL-----KKKREER 346
E + Q E R EE R + E E+ EK+ KQ+E E EE +K RE+
Sbjct: 574 RQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKM-WKQEEKIREQEEKIQEQEEKIREQE 632
Query: 347 RKVLEEEEQRRKQE----EADRKLREEEEKRRLKEEIERRRAEAAEKRQK 392
K+ E+EE ++QE E + K+ E+EEK + +EE R+ E +++K
Sbjct: 633 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEK 682
Score = 101 bits (251), Expect = 2e-21
Identities = 91/402 (22%), Positives = 191/402 (47%), Gaps = 35/402 (8%)
Query: 4 FERRRELRRQK-----REEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES 58
+E+ ++RRQ+ +EE E E +++ E+E R+ + R++ RQ+QE +
Sbjct: 373 WEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 432
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
Q + + ++E K ++ +E + R EE+RQ+ QE + RQ
Sbjct: 433 WRQ---------EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQE--QEEMWRQ 481
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
+E + R+ + + E K+E+ RQE +I E E + ++ WR
Sbjct: 482 EEKIHEQEEIW-----RQKEKMHEQEEKIRKQEEKVWRQEE-KIREQEEKIREQEEKMWR 535
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEK 238
E+ +++++ EEE+ + E + +E+ K+ + EK++E + ++E EK
Sbjct: 536 QEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQE---EK 592
Query: 239 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGA 298
I++ +E ++E + M +++ + + + K++ E +E +
Sbjct: 593 IREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQ--EEMTQEQEEKMG 650
Query: 299 PQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRK 358
Q E EE + + ET + EK+++++++ E+ +K RE+ + E+EE+ +
Sbjct: 651 EQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIR---EQEEKIREQEEMMQEQEEKMWE 707
Query: 359 QE----EADRKLREEEEK-RRLKEEIERRRAEAAEKRQKMPE 395
QE E + K++E+EEK RR +E++ + ++ +KM E
Sbjct: 708 QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 90.1 bits (222), Expect = 5e-18
Identities = 89/339 (26%), Positives = 166/339 (48%), Gaps = 35/339 (10%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+N++ DEE K Q ++ +E + K L+ LER K L
Sbjct: 211 RNTITDEELKEKNAKLQ----EKLQLVESEKSEIQLNVKELKRKLERAK----------L 256
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WRDAEENKKED 187
LP +++Q AE + KE +S S + + ++EE E + Q+ + WR EE +E
Sbjct: 257 LLPQQQLQ---AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ-EEKIQEW 312
Query: 188 KEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEE----IKDEKIKKDK 243
+EK +E+EEK + E + E+ K++ + E + E + +++E K+EK+++ +
Sbjct: 313 EEKIQEQEEKIRE---QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE 369
Query: 244 EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD-TKEAEGAPQVE 302
E E + M R++ K + + K+ E + R + +E E + E
Sbjct: 370 EMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE 429
Query: 303 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELK--KKREERRKVLEEEEQRRKQE 360
A +E + R E + E EK +Q+E E E+++ +KR+E+ ++ +EE+ +QE
Sbjct: 430 AKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQE 489
Query: 361 EADR---KLREEEEK-RRLKEEIERRRAEAAEKRQKMPE 395
E R K+ E+EEK R+ +E++ R+ + E+ +K+ E
Sbjct: 490 EIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528
Score = 62.4 bits (150), Expect = 1e-09
Identities = 54/259 (20%), Positives = 125/259 (48%), Gaps = 26/259 (10%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRND--DDEEEAARERRRRARQERLRQKQEE--E 57
++ R++E ++ E++R + E++ Q + EE+ + + RQE ++QEE
Sbjct: 489 EEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR 548
Query: 58 SLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFL--ERLARREERRQK------ 109
++ +Q ++ + ++E K ++ +E + E++ +EE+RQ+
Sbjct: 549 EEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMW 608
Query: 110 ----RLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEET 165
+++E E+ +E + I + + + E + E+EEK ++E+ + E+
Sbjct: 609 KQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQ-EQE 667
Query: 166 ETVTKSYQK-----NDWRDAEENKKEDKEKEEEEEEK----PKRGSIGENQGEEKGTKVQ 216
ET+ + +K R+ EE +E +E +E+EEK ++ E + +E+ K++
Sbjct: 668 ETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 727
Query: 217 AKREKLQEDKPTFKKEEIK 235
+ EK+ E + +++E K
Sbjct: 728 RQEEKMWEQEVRLRQQEEK 746
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 106 bits (265), Expect = 5e-23
Identities = 115/476 (24%), Positives = 207/476 (43%), Gaps = 61/476 (12%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRND--DDEEEAARERRRRARQERLRQKQEEESLGQV 62
E+ +++R+Q+ E+M + ER+ Q + EE+ R+ +R QE+ ++QE+E +
Sbjct: 245 EQEKKIRKQE-EKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKE----L 299
Query: 63 TDQVEVNAQNS-VPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+Q ++ Q + ++E K ++ +E + + E+ +Q R QE R +E
Sbjct: 300 REQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 359
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
D L RM+ E EK ++ E +ER + E T Q+ + E
Sbjct: 360 RMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE 419
Query: 182 ENKKEDKEKEEEEEEKP--KRGSIGENQGEEKGTKVQAKREKL----------------- 222
EN E +EKE +++ P K + + +E+ K+ + EK+
Sbjct: 420 ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE 479
Query: 223 ----QEDKPTFKKEEIKDEKIK-----------------KDKEPKEEVKSFMDRKKGFTE 261
QED+ ++E+++D++ K K++ +E+ K + +K E
Sbjct: 480 KMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREE 539
Query: 262 VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEE 321
K+Q E T + R R +E E + E + +E + R E + E
Sbjct: 540 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWE 599
Query: 322 FEKLKQKQQEAALELEELKKKREERRKVLEEE----EQRRKQEEADRKLREEEEKRRLKE 377
E+ Q+Q+E E EE ++EE K+ E+E EQ K +E + K+ E+EEK R +E
Sbjct: 600 QEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQE 659
Query: 378 EIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSG 433
E + E EK Q E ++K +G K+ E+ E + +K G
Sbjct: 660 E---KMREQEEKMQGQEEKMREQEEK------MQGQEEKMREQEEKMRGQEEKMWG 706
Score = 102 bits (255), Expect = 7e-22
Identities = 101/432 (23%), Positives = 198/432 (45%), Gaps = 41/432 (9%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
++ R+ E R++ +++R + E++ Q EE RE+ + R++ + +++E+ L +
Sbjct: 234 EEMWRQEEELREQEKKIRKQEEKMWRQ------EERLREQEGKMREQEEKMRRQEKRLRE 287
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF---------LERLARREER-----R 107
+ E+ Q E+ K Q++ +E + E++ R+EER +
Sbjct: 288 --QEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 345
Query: 108 QKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET 167
Q R QE R +E D L RM+ E EK ++ E +ER + E
Sbjct: 346 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEE 405
Query: 168 VTKSYQKNDWRDAEENKKEDKEKEEEEEEKP--KRGSIGENQGEEKGTKVQAKREKLQED 225
T Q+ + EEN E +EKE +++ P K + + +E+ K+ + EK+++
Sbjct: 406 ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 465
Query: 226 KPTF----------KKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 275
+ + K E +D+ +++++ +++ + D+++ E + E +
Sbjct: 466 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMRE 525
Query: 276 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 335
+ R T+E E + K EE R R E + E E++ ++Q+E E
Sbjct: 526 QKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQE 585
Query: 336 LEELKKKREERRKVLEEEEQRRKQE----EADRKLREEEEKRRLKEEIERRRAEAAEKRQ 391
EE K RE+ K+ E+EE+ ++QE E + K+ E+EE+ +++E+ E E EK Q
Sbjct: 586 QEE--KMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQ-EEMMWEQEEKMQ 642
Query: 392 KMPEDGLSDDKK 403
+ E ++K
Sbjct: 643 EQEEKMWEQEEK 654
Score = 95.5 bits (236), Expect = 1e-19
Identities = 93/404 (23%), Positives = 188/404 (46%), Gaps = 46/404 (11%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ----VTD 64
E R+K E MR E E++ Q EEE RER ++ R+E +++EE + + + +
Sbjct: 366 ERLREKEERMR-EQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424
Query: 65 QVEVN-AQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER---------RQKRLQEA 114
Q E Q +P+++ K E +++ E R +E RQ++++E
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484
Query: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEET---ETVTKS 171
++ E + + D + + + + EKEE+ +++ ++ EE E T+
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQE 544
Query: 172 YQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKK 231
+K W E+ ++E++ +E E++ + + E E+ K+Q + EK++E + +
Sbjct: 545 QEKKTWDQEEKMREEERMREREKKMREE-----EEMMREQEEKMQEQEEKMREQEEKMWE 599
Query: 232 EEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD 291
+E EK+++ +E E + M ++ E K Q E M + +
Sbjct: 600 QE---EKMQEQEEKMWEQEEKMWEQE--EEDKMQEQEEMMWEQEEK-------------- 640
Query: 292 TKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLE 351
+E E + K E+ + R + E + ++ K ++QE ++ +E +K RE+ K+
Sbjct: 641 MQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQE-EKMREQEEKMRG 699
Query: 352 EEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 395
+EE+ QEE K+ +EEK +EE+ + ++++KM E
Sbjct: 700 QEEKMWGQEE---KMWGQEEKMWGQEEMREKEERIRDQKEKMQE 740
Score = 81.3 bits (199), Expect = 2e-15
Identities = 73/331 (22%), Positives = 158/331 (47%), Gaps = 13/331 (3%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+N++ +EE K Q ++ E + K L+ LER K P + +L
Sbjct: 177 RNTITNEELKKKNAELQ----EKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTL 232
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEK 190
R + + E E ++++ + ++ + E E + ++ R + ++++KE
Sbjct: 233 QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKEL 292
Query: 191 EEEEEE--KPKRGSIGENQGEEKGTKVQAKREKLQE-DKPTFKKEEIKDEKIKKDKEPKE 247
E+E+E + K+ E Q +E+ K+ + EK++E ++ +++EE E+ K+ +E ++
Sbjct: 293 REQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 352
Query: 248 EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL 307
+++ +R E + E M + K E + + +E + + E +
Sbjct: 353 KMRDQEERMWEQDERLREKEERMREQEKMWEQE-EKMQEEERIREREKKMREEEETMREQ 411
Query: 308 EELRRRRGET--ESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE---A 362
EE +++ E E EE E +Q+ E +L E +K +E+ K+ E+EE+ R QEE
Sbjct: 412 EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ 471
Query: 363 DRKLREEEEKRRLKEEIERRRAEAAEKRQKM 393
++K+ +E+ R ++++ + + ++ QKM
Sbjct: 472 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 502
Score = 68.9 bits (167), Expect = 1e-11
Identities = 51/228 (22%), Positives = 112/228 (49%), Gaps = 10/228 (4%)
Query: 5 ERRRELRR--QKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQV 62
ER RE ++ Q+ E+MR E + ++ D+EE RE R +E+ + ++EEE + +
Sbjct: 521 ERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREK-KMREEEEMMREQ 579
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD 122
++++ + + ++E K +++ +E + + E+ + ++QE E E +
Sbjct: 580 EEKMQ-EQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQE 638
Query: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEE 182
+ + + + + E + E+EEK + ++E+ +E + Q+ R+ EE
Sbjct: 639 EKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEK---MQGQEEKMREQEE 695
Query: 183 NKKEDKEKEEEEEEK---PKRGSIGENQGEEKGTKVQAKREKLQEDKP 227
+ +EK +EEK + G+ + EK +++ ++EK+QE P
Sbjct: 696 KMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLP 743
Score = 55.1 bits (131), Expect = 2e-07
Identities = 45/143 (31%), Positives = 77/143 (53%), Gaps = 13/143 (9%)
Query: 261 EVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGA----PQVEAGKRLEELRRRRGE 316
E+K +N E + KL+ E+ S ++ E A PQV+ EE+ R+ E
Sbjct: 184 ELKKKNAE-LQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ--E 240
Query: 317 TESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE----EADRKLREEEEK 372
E E EK +KQ+E EE + RE+ K+ E+EE+ R+QE E +++LRE+E++
Sbjct: 241 EELREQEKKIRKQEEKMWRQEE--RLREQEGKMREQEEKMRRQEKRLREQEKELREQEKE 298
Query: 373 RRLKEEIERRRAEAAEKRQKMPE 395
R ++++ + + E+ +KM E
Sbjct: 299 LREQKKLREQEEQMQEQEEKMWE 321
Score = 44.3 bits (103), Expect = 3e-04
Identities = 39/150 (26%), Positives = 70/150 (46%), Gaps = 41/150 (27%)
Query: 308 EELRRRRGETESEEFEKLKQKQQEAALELEELKKK------------------------- 342
EEL+++ E + E+ + ++ E L ++ELK+K
Sbjct: 183 EELKKKNAELQ-EKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEE 241
Query: 343 --REERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSD 400
RE+ +K+ ++EE+ +QEE +LRE+E K R +EE RR+ EKR + E L +
Sbjct: 242 ELREQEKKIRKQEEKMWRQEE---RLREQEGKMREQEEKMRRQ----EKRLREQEKELRE 294
Query: 401 DKKPFKCFTPKGSSLKIEERAEFLNKSVQK 430
+K + K+ E+ E + + +K
Sbjct: 295 QEKELR------EQKKLREQEEQMQEQEEK 318
Score = 37.0 bits (84), Expect = 0.048
Identities = 25/121 (20%), Positives = 64/121 (52%), Gaps = 11/121 (9%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
D + + E+ ++ E+M+ + E++ ++EE RE+ + R++ + + +EE + +
Sbjct: 625 DKMQEQEEMMWEQEEKMQEQEEKMW------EQEEKMREQEEKMREQEEKMQGQEEKMRE 678
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF--LERLARREERRQKRLQEALERQK 119
++++ + + ++E K ++ G +E + E++ +EE R+K +E + QK
Sbjct: 679 QEEKMQ-GQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREK--EERIRDQK 735
Query: 120 E 120
E
Sbjct: 736 E 736
Score = 29.6 bits (65), Expect = 7.7
Identities = 26/89 (29%), Positives = 44/89 (49%), Gaps = 18/89 (20%)
Query: 323 EKLKQKQQEAALEL-------EELKKKREERRKVL-----EEEEQRRKQEEADRKLRE-- 368
E+L +++ +LEL EELKKK E ++ L E+ E + +E RKL
Sbjct: 162 EELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAK 221
Query: 369 ----EEEKRRLKEEIERRRAEAAEKRQKM 393
+ + L+EE+ R+ E E+ +K+
Sbjct: 222 FLLPQVQTNTLQEEMWRQEEELREQEKKI 250
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 104 bits (260), Expect = 2e-22
Identities = 90/384 (23%), Positives = 189/384 (49%), Gaps = 26/384 (6%)
Query: 12 RQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQ 71
R++ ++R + ++ Q E+E + R + Q R ++ Q E GQV +Q +
Sbjct: 55 REQEGQVREQEGQVREQEGQVREQEG--QVREQEGQVREQEGQVREQEGQVREQ-----E 107
Query: 72 NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLS 131
V ++E + QV + + RE+ Q R QE R++E + +
Sbjct: 108 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV- 166
Query: 132 LPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKE 191
R + E E +E++ + R++ ++ E E ++ E+ +K++++
Sbjct: 167 ---REQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMG 223
Query: 192 EEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKS 251
E+EE+ K+ E Q E+ +VQ + E++Q+ + +K+E E++++ +E E +
Sbjct: 224 EQEEQMRKQ----EEQMGEQEEQVQKQEEQVQKQEEQMRKQE---EQMREQEEQMREQEE 276
Query: 252 FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR 311
M ++K TE + Q GE +++ E R + +E + + GK+ E++
Sbjct: 277 QMLKQKEQTEQEEQTGE-QEEQMREQEEQM-REQEEQMREQEEQMREQEEQMGKQEEQMW 334
Query: 312 RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 371
++ + ++ + KQ++Q E E+++K+ E+ RK +EEQ RKQEE RK +EE+
Sbjct: 335 EQKEQMWEQKEQMWKQEEQMGEQE-EQMQKQEEQVRK---QEEQMRKQEEQMRK--QEEQ 388
Query: 372 KRRLKEEIERRRAEAAEKRQKMPE 395
R+ +E++ ++ + E++++M E
Sbjct: 389 MRKQEEQMGEQKEQMGEQKEQMRE 412
Score = 80.5 bits (197), Expect = 4e-15
Identities = 82/365 (22%), Positives = 164/365 (44%), Gaps = 27/365 (7%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEE----ESLG 60
E+ ++R Q+ + E + + ++E RE+ + R++ + +++E E G
Sbjct: 84 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 143
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
QV +Q + V ++E + QV + + RE+ Q R QE ++E
Sbjct: 144 QVREQ-----EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQE 198
Query: 121 FDPTITDASLSLPSRRMQNDTAE----NETTEKEEKSESRQERYEIEETETVTKSYQKND 176
+ + +MQ + E K+E+ QE ++ E V K Q+
Sbjct: 199 GQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQK--QEEQ 256
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKD 236
R EE +E +E+ E+EE+ + Q E+ G + + RE QE++ ++E++++
Sbjct: 257 MRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMRE--QEEQMREQEEQMRE 314
Query: 237 EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAE 296
+ +++ +E+ + +++ E K Q E K E G + K+ E
Sbjct: 315 Q----EEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQM----GEQEEQMQKQEE 366
Query: 297 GAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQR 356
+ E R +E + R+ E + + E+ +Q+E E +E +++EE ++ E++EQ
Sbjct: 367 QVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEE--QMGEQKEQM 424
Query: 357 RKQEE 361
RKQEE
Sbjct: 425 RKQEE 429
Score = 73.6 bits (179), Expect = 5e-13
Identities = 73/390 (18%), Positives = 177/390 (45%), Gaps = 32/390 (8%)
Query: 44 RARQERLRQKQEE--ESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLA 101
R E L++K E E L Q+ + + Q + + + K T + + +
Sbjct: 3 RITNEELKEKNAELQEEL-QLVETEKSEIQLHIKELKRKLETDKIPLPQEGQV------- 54
Query: 102 RREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYE 161
RE+ Q R QE R++E + + R + E E +E++ + R++ +
Sbjct: 55 -REQEGQVREQEGQVREQEGQVREQEGQV----REQEGQVREQEGQVREQEGQVREQEGQ 109
Query: 162 IEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREK 221
+ E E + ++ + ++E + +E+E + + + G + E +G+ + + Q + ++
Sbjct: 110 VREQEGQVRE------QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 163
Query: 222 LQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTF 281
Q + + E + + +++ + +E+ +++ E + Q GE K E
Sbjct: 164 GQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQM- 222
Query: 282 SRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKK 341
G + K+ E + G++ E+++++ + + +E + KQ++Q E E++++
Sbjct: 223 ---GEQEEQMRKQEE-----QMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQE-EQMRE 273
Query: 342 KREERRKVLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRAEAAEKRQKMPEDGLSD 400
+ E+ K E+ EQ + E + ++RE+EE+ R +E++ + + E+ ++M +
Sbjct: 274 QEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQM 333
Query: 401 DKKPFKCFTPKGSSLKIEERAEFLNKSVQK 430
++ + + K K EE+ + +QK
Sbjct: 334 WEQKEQMWEQKEQMWKQEEQMGEQEEQMQK 363
Score = 68.6 bits (166), Expect = 1e-11
Identities = 52/281 (18%), Positives = 132/281 (46%), Gaps = 10/281 (3%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
E+ ++R Q+ + E + + ++E RE+ + ++ + ++EE +G+ +
Sbjct: 154 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEE 213
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Q++ + EE E +++ E +++E + ++ +E + Q+E
Sbjct: 214 QMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMRE 273
Query: 125 ITDASLSLPSRRMQND-TAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
+ L + Q + T E E +E++ + R++ ++ E E + ++ + E+
Sbjct: 274 QEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQM 333
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEE----IKDEKI 239
++ ++ E++E+ K+ E Q E+ ++Q + E++++ + +K+E ++E++
Sbjct: 334 WEQKEQMWEQKEQMWKQ----EEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQM 389
Query: 240 KKDKEPKEEVKSFM-DRKKGFTEVKSQNGEFMTHKLKHTEN 279
+K +E E K M ++K+ E + Q GE K E+
Sbjct: 390 RKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEH 430
Score = 62.8 bits (151), Expect = 8e-10
Identities = 56/233 (24%), Positives = 108/233 (46%), Gaps = 18/233 (7%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
+ +++ E ++ E+MR + E++ Q EE+ ++ + +QE +KQEE Q
Sbjct: 213 EQMQKQEEQMGEQEEQMRKQEEQMGEQ-----EEQVQKQEEQVQKQEEQMRKQEE----Q 263
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-REERRQKRLQEALERQKE 120
+ +Q E + + K T + G+ E E+ + RE+ Q R QE R++E
Sbjct: 264 MREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQE 323
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ + +M + E K+E+ QE ++ E V K Q+ R
Sbjct: 324 EQMGKQEEQMWEQKEQMWE---QKEQMWKQEEQMGEQEEQMQKQEEQVRK--QEEQMRKQ 378
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEE 233
EE ++ +E+ ++EE + G E GE+K +++ + E++ E K +K+E
Sbjct: 379 EEQMRKQEEQMRKQEE--QMGEQKEQMGEQK-EQMREQEEQMGEQKEQMRKQE 428
Score = 58.2 bits (139), Expect = 2e-08
Identities = 40/195 (20%), Positives = 88/195 (45%), Gaps = 20/195 (10%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
+ ++ E R++ E+MR + E++ Q+ ++EE E+ + R++ + +++EE + +
Sbjct: 255 EQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMRE 314
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+Q+ + EE E ++ E +E + ++ +E + +Q+E
Sbjct: 315 QEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEE- 373
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
+M+ + E K+E+ +QE E+ E + + QK R+ E
Sbjct: 374 --------------QMRK---QEEQMRKQEEQMRKQEEQMGEQKEQMGE--QKEQMREQE 414
Query: 182 ENKKEDKEKEEEEEE 196
E E KE+ ++EE
Sbjct: 415 EQMGEQKEQMRKQEE 429
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 99.8 bits (247), Expect = 6e-21
Identities = 87/406 (21%), Positives = 193/406 (47%), Gaps = 42/406 (10%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIA-YQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
+++ E L +Q+ E+M + E+I ++ ++EE RE+ + R++ + +++EE +
Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM 344
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
+ EE E +++ LE + +E + + L+E + Q+
Sbjct: 345 WE--------------KEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQE 390
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
+ +R + + + +E++++ ++ +I E E + +K WR
Sbjct: 391 KIREQ--------EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ 442
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEI---KD 236
E+ +++K +EEE+ ++ + E + E+ ++ ++EK+ E + K+EE ++
Sbjct: 443 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQ-EEIWRQKEKMHEQEKIRKQEEKVWRQE 501
Query: 237 EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAE 296
EK+ +E E + M R++ + + K++ E + ++ E
Sbjct: 502 EKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMG---EQEE 558
Query: 297 GAPQVEAGKRLEELRRRRGETESEEFEKLKQK------QQEAALELEELKKKREERRKVL 350
+ E +R EE R + E E+ EK++++ Q+E E EE+ +++EE K+
Sbjct: 559 KMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEE--KMW 616
Query: 351 EEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRAEAAEKRQKMPE 395
E+EE+ +QEE K++E+EEK RR +E++ + ++ +KM E
Sbjct: 617 EQEEKMCEQEE---KMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 659
Score = 90.5 bits (223), Expect = 4e-18
Identities = 89/372 (23%), Positives = 179/372 (48%), Gaps = 29/372 (7%)
Query: 48 ERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE-- 105
+ L++K E L Q++ A + + ++ + QVE E RL +++E
Sbjct: 245 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE---ENELWNRLNQQQEEK 301
Query: 106 --RRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE 163
R+++++QE E+ +E + I + + + + E EKEEK ++E +
Sbjct: 302 MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM--MW 359
Query: 164 ETETVTKSYQKNDW------RDAEENKKEDKEKEEEEEEKPKRGSIGENQG-EEKGTKVQ 216
E E + ++ W R+ EE E ++ E+EE++ + I E + +E+ K+
Sbjct: 360 EKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 419
Query: 217 AKREKLQEDKPTFKKEEIK----DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTH 272
+ EK++E + +++E K +EKI + ++ +EE K + E K + E +
Sbjct: 420 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWR 479
Query: 273 KLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEA 332
+ + V +E + Q E + EE R+ E E+ EK+++ Q+E
Sbjct: 480 QKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIRE-QEEK 538
Query: 333 ALELEELKKKREER-----RKVLEEEEQRRKQE---EADRKLREEEEKRRLKEEIERRRA 384
E EE+ +++EE+ K+ E+E+ RR++E E + K+RE++EK R +EE +
Sbjct: 539 IREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQE 598
Query: 385 EAAEKRQKMPED 396
E ++++M ++
Sbjct: 599 EKIREQEEMMQE 610
Score = 85.9 bits (211), Expect = 9e-17
Identities = 85/334 (25%), Positives = 161/334 (48%), Gaps = 40/334 (11%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+N++ DEE K Q ++ +E + K L+ LER K L
Sbjct: 211 RNTITDEELKEKNAKLQ----EKLQLVESEKSEIQLNVKELKRKLERAK----------L 256
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WRDAEENKKED 187
LP +++Q AE + KE +S S + + ++EE E + Q+ + WR EE +E
Sbjct: 257 LLPQQQLQ---AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ-EEKIQEW 312
Query: 188 KEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKE 247
+EK +E+EEK + E+ K++ + EK++ + + K+EK+++ +E
Sbjct: 313 EEKIQEQEEKIR----------EQEEKIREQEEKMRRQEEMMWE---KEEKMRRQEEMMW 359
Query: 248 EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT-KEAEGAPQVEAGKR 306
E + M R + K + + K+ E + R + +E E + EA
Sbjct: 360 EKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 419
Query: 307 LEELRRRRGETESEEFEKLKQKQQEAALELEELKK--KREERRKVLEEEEQRRKQEEADR 364
+E + R E + E EK +Q+E E E++++ KR+E+ ++ +EE+ R+QEE R
Sbjct: 420 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWR 479
Query: 365 ---KLREEEEKRRLKEEIERRRAEAAEKRQKMPE 395
K+ E+E+ R+ +E++ R+ + ++ +K+ E
Sbjct: 480 QKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIRE 513
Score = 62.4 bits (150), Expect = 1e-09
Identities = 58/258 (22%), Positives = 126/258 (48%), Gaps = 21/258 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQ 65
R+ E R++ E++R + +++ Q E+E RE +R QE + +++E+ + +Q
Sbjct: 420 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK-----IREQ 474
Query: 66 VEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF--LERLARREE---RRQKRLQEALERQKE 120
E+ Q E+ K +V +E E++ +EE R++++++E E+ +E
Sbjct: 475 EEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIRE 534
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ I + + + + E E +E++ RQE E+ E + + QK R+
Sbjct: 535 QEEKIREQEEMM--QEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIRE--QKEKIREQ 590
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIK----D 236
EE E +EK E+E+ + E + E+ K+ + EK+QE + +++E K +
Sbjct: 591 EEKIWEQEEKI-REQEEMMQEQ--EEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 647
Query: 237 EKIKKDKEPKEEVKSFMD 254
++++ +E +E + ++
Sbjct: 648 VRLRQQEEKMQEHQEHLE 665
Score = 29.6 bits (65), Expect = 7.7
Identities = 13/67 (19%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEEESLG 60
+ + E+ +++ E+M + E++ Q ++EE R + + ++ +R +Q+EE +
Sbjct: 599 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 658
Query: 61 QVTDQVE 67
+ + +E
Sbjct: 659 EHQEHLE 665
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 99.8 bits (247), Expect = 6e-21
Identities = 92/401 (22%), Positives = 194/401 (48%), Gaps = 37/401 (9%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIA-YQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
+++ E L +Q+ E+M + E+I ++ ++EE RE+ + R++ + +++EE +
Sbjct: 346 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM 405
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
+ +++ + EE E + E++ EE+ + QE + Q+
Sbjct: 406 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE------EKIRELEEKMHE--QEKIREQE 457
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
E R+ + E E +++E RQE +I E E + ++ WR
Sbjct: 458 E-------------KRQEEEKIREQEKRQEQEAKMWRQEE-KIREQEEKIREQEEKMWRQ 503
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIK---- 235
E+ +++K +EEE+ ++ + E + E+ ++ ++EK+ E + +K+E K
Sbjct: 504 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQ-EEIWRQKEKIHEQEEKIRKQEEKMWRQ 562
Query: 236 DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEA 295
+EK+ +E E + + R++ +++ Q + + K E + +E
Sbjct: 563 EEKMHDQEEKIREQEEKVWRQE--EKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEE 620
Query: 296 EGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQ 355
+ Q E + EE RR+ E E+ +K+++ Q+E E EE+ +++EE K+ E+EE+
Sbjct: 621 KMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE-QEEKIREQEEMMQEQEE--KMWEQEEK 677
Query: 356 RRKQEEADRKLREEEEK-RRLKEEIERRRAEAAEKRQKMPE 395
+QEE K++E+EEK RR +E++ + ++ +KM E
Sbjct: 678 MCEQEE---KMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 715
Score = 86.7 bits (213), Expect = 5e-17
Identities = 89/379 (23%), Positives = 170/379 (44%), Gaps = 58/379 (15%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEE--ESLGQVT 63
R +E + +++EEM E E + +E +E + R ++E + +K+E+ E ++
Sbjct: 392 REQEEKMRRQEEMMWEKEE---KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH 448
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
+Q ++ Q EE K + E + + E R +E + + +E + RQ+E
Sbjct: 449 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEE--K 506
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
+ +R + + + + E+ E +++ +I E E + ++ WR +E
Sbjct: 507 IHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWR--QEE 564
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDK 243
K D+E++ E+E+ KV + EK++E + +++E EKI++ +
Sbjct: 565 KMHDQEEKIREQEE----------------KVWRQEEKIREQEEKIREQE---EKIREQE 605
Query: 244 EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEA 303
E +E + K G E K E K++ E R E
Sbjct: 606 EMTQE----QEEKMGEQEEKMCEQE---EKMQEQEEKMRRQ-----------------EE 641
Query: 304 GKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE--- 360
R +E + R E + E E++ Q+Q+E E EE K E+ K+ E+EE+ R+QE
Sbjct: 642 KIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE--KMCEQEEKMQEQEEKMRRQEEKM 699
Query: 361 -EADRKLREEEEKRRLKEE 378
E + +LR++EEK + +E
Sbjct: 700 WEQEVRLRQQEEKMQEHQE 718
Score = 84.7 bits (208), Expect = 2e-16
Identities = 86/335 (25%), Positives = 163/335 (48%), Gaps = 41/335 (12%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+N++ DEE K Q ++ +E + K L+ LER K L
Sbjct: 272 RNTITDEELKEKNAKLQ----EKLQLVESEKSEIQLNVKELKRKLERAK----------L 317
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WRDAEENKKED 187
LP +++Q AE + KE +S S + + ++EE E + Q+ + WR EE +E
Sbjct: 318 LLPQQQLQ---AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ-EEKIQEW 373
Query: 188 KEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKE 247
+EK +E+EEK + E+ K++ + EK++ + + K+EK+++ +E
Sbjct: 374 EEKIQEQEEKIR----------EQEEKIREQEEKMRRQEEMMWE---KEEKMRRQEEMMW 420
Query: 248 EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT-KEAEGAPQVEAGKR 306
E + M R++ K + + K+ E + R + +E E + EA
Sbjct: 421 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 480
Query: 307 LEELRRRRGETESEEFEKLKQKQQEAALELEELKK--KREERRKVLEEEEQRRKQEEADR 364
+E + R E + E E+ +Q+E E E++++ KR+E+ ++ +EE+ R+QEE R
Sbjct: 481 RQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWR 540
Query: 365 ---KLREEEEK-RRLKEEIERRRAEAAEKRQKMPE 395
K+ E+EEK R+ +E++ R+ + ++ +K+ E
Sbjct: 541 QKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIRE 575
Score = 84.0 bits (206), Expect = 3e-16
Identities = 89/401 (22%), Positives = 185/401 (46%), Gaps = 54/401 (13%)
Query: 48 ERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE-- 105
+ L++K E L Q++ A + + ++ + QVE E RL +++E
Sbjct: 306 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE---ENELWNRLNQQQEEK 362
Query: 106 --RRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE 163
R+++++QE E+ +E + I + + + + E EKEEK RQE E
Sbjct: 363 MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR-RQEEMMWE 421
Query: 164 ETETVTKSYQ-----KNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQG-EEKGTKVQA 217
+ E + + + + R+ EE E ++ E+EE++ + I E + +E+ K+
Sbjct: 422 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 481
Query: 218 KREKLQEDKPTFKKEEIK----DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHK 273
+ EK++E + +++E K +EKI + ++ +EE K + E K + E + +
Sbjct: 482 QEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQ 541
Query: 274 LKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAA 333
+ Q E ++ EE R+ E ++ EK+++++++
Sbjct: 542 KEKIHE--------------------QEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVW 581
Query: 334 LELEELKKKREERRKVLEEEEQRRKQE----EADRKLREEEEKRRLKEEIERRRAEAAEK 389
+ E++ RE+ K+ E+EE+ R+QE E + K+ E+EEK +EE + + E+
Sbjct: 582 RQEEKI---REQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE----KMQEQEE 634
Query: 390 RQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 430
+ + E+ + + +K + KI E+ E + + +K
Sbjct: 635 KMRRQEEKIREQEKKI-----REQEEKIREQEEMMQEQEEK 670
Score = 68.2 bits (165), Expect = 2e-11
Identities = 57/252 (22%), Positives = 127/252 (50%), Gaps = 21/252 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQ 65
R+ E R++ E++R + E++ Q E+E RE +R QE + +++E+ + +Q
Sbjct: 481 RQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK-----IREQ 535
Query: 66 VEVNAQNS-VPDEEAKTTTTNTQVEGDDEAAF--LERLARREE---RRQKRLQEALERQK 119
E+ Q + ++E K ++ +E E++ +EE R++++++E E+ +
Sbjct: 536 EEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIR 595
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
E + I + + + E + E+EEK + ++E+ +E + Q+ R+
Sbjct: 596 EQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKI---REQEKKIRE 652
Query: 180 AEENKKEDKEKEEEEEEK----PKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIK 235
EE +E +E +E+EEK ++ E + +E+ K++ + EK+ E + +++E
Sbjct: 653 QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQE-- 710
Query: 236 DEKIKKDKEPKE 247
EK+++ +E E
Sbjct: 711 -EKMQEHQEHLE 721
Score = 59.3 bits (142), Expect = 9e-09
Identities = 58/278 (20%), Positives = 134/278 (48%), Gaps = 15/278 (5%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ---V 62
R +E +RQ+ E++R + +R + +EE RE+ + R++ + ++EE + + +
Sbjct: 454 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKI 513
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD 122
++ + Q + +E K ++ E R++E + R +E + Q+E
Sbjct: 514 REEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEE-- 571
Query: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEE 182
I + + + + E + E+EEK ++E + E+ E + + +K ++ +
Sbjct: 572 -KIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQ-EQEEKMGEQEEKMCEQEEKM 629
Query: 183 NKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQE-DKPTFKKEEIKDEKIKK 241
++E+K + +EE+ + + I E + K++ + E +QE ++ +++EE E+ +K
Sbjct: 630 QEQEEKMRRQEEKIREQEKKIREQE-----EKIREQEEMMQEQEEKMWEQEEKMCEQEEK 684
Query: 242 DKEPKEEVKSFMDRKKGFTEVK-SQNGEFMTHKLKHTE 278
+E +E+++ + K EV+ Q E M +H E
Sbjct: 685 MQEQEEKMRR-QEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 29.6 bits (65), Expect = 7.7
Identities = 13/67 (19%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEEESLG 60
+ + E+ +++ E+M + E++ Q ++EE R + + ++ +R +Q+EE +
Sbjct: 655 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 714
Query: 61 QVTDQVE 67
+ + +E
Sbjct: 715 EHQEHLE 721
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 95.5 bits (236), Expect = 1e-19
Identities = 100/396 (25%), Positives = 190/396 (47%), Gaps = 36/396 (9%)
Query: 5 ERRRELRRQKREEMRL-EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E +E + +E+++L E+E+ Q N + + + Q++L+ E + LG+
Sbjct: 205 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA--EADHLGKEL 262
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER---RQKRLQEALERQKE 120
V Q V + E N Q E E++ R+EE+ R++++QE E+ +E
Sbjct: 263 QSVSAKLQAQVEENEL-WNRLNQQQE--------EKMWRQEEKIQEREEKIQEQEEKIRE 313
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ + + + + E EKEEK +E+ + E E + + +K
Sbjct: 314 QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK--MHEQEKIREQEEKRQ---- 367
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIK 240
EE K ++EK +E+E K R E + E+ K++ + E +QE + ++E EK+
Sbjct: 368 EEEKIREQEKRQEQEAKMWRQ---EEKIREQEEKIREQEEMMQEQEEKMGEQE---EKMW 421
Query: 241 KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 300
+ +E +E + M R++ +++ Q + + K E + +E + Q
Sbjct: 422 EQEEEMQEQEEKMRRQE--EKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQ 479
Query: 301 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 360
EA + +E + RR E + E EK ++Q+E E EE+ +++EE K+ E+EE+ +QE
Sbjct: 480 -EAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEE--KMWEQEEKMCEQE 536
Query: 361 EADRKLREEEEKRRLKEE-IERRRAEAAEKRQKMPE 395
E K++E+EEK R +EE + + ++ +KM E
Sbjct: 537 E---KMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 88.2 bits (217), Expect = 2e-17
Identities = 95/375 (25%), Positives = 176/375 (46%), Gaps = 64/375 (17%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+N++ DEE K Q ++ +E + K L+ LER K L
Sbjct: 199 RNTITDEELKEKNAKLQ----EKLQLVESEKSEIQLNVKELKRKLERAK----------L 244
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WRDAEENKKED 187
LP +++Q AE + KE +S S + + ++EE E + Q+ + WR EE +E
Sbjct: 245 LLPQQQLQ---AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ-EEKIQER 300
Query: 188 KEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEI----KDEKIKKDK 243
+EK +E+EEK + E+ K++ + E + E + +++E K+EKI++ +
Sbjct: 301 EEKIQEQEEKIR----------EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 350
Query: 244 EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEA 303
E E + ++ E K Q E + + K E A + +E + Q E
Sbjct: 351 EKMHEQEKIREQ-----EEKRQEEEKIREQEKRQEQ-------EAKMWRQEEKIREQEEK 398
Query: 304 GKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKK----REERRKVLEEEEQRRKQ 359
+ EE+ + + E E+ EK+ ++++E + E+++++ RE+ +K+ E+EE+ R+Q
Sbjct: 399 IREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ 458
Query: 360 EEADRKLREEEEKRRLKE----EIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSL 415
EE ++E+EEK +E E E + E EK ++ E +KK +
Sbjct: 459 EE---MMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKK------IREQEE 509
Query: 416 KIEERAEFLNKSVQK 430
KI E+ E + + +K
Sbjct: 510 KIREQEEMMQEQEEK 524
Score = 70.5 bits (171), Expect = 4e-12
Identities = 58/244 (23%), Positives = 116/244 (47%), Gaps = 17/244 (6%)
Query: 2 DDFERRRELRRQKREEMR------LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQE 55
+ R+ E+ +K E++R E E+I Q EEE RE+ +R QE +QE
Sbjct: 330 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 389
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERR----QKRL 111
E+ + + +++ + EE E ++E E RR+E + +K++
Sbjct: 390 EK-IREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKI 448
Query: 112 QEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKS 171
+E E+ +E + + + + + + E E +E++ + R++ +I E E +
Sbjct: 449 REQEEKIREQEEMMQEQEEKMGEQ--EGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIRE 506
Query: 172 YQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKK 231
Q+ R+ EE +E +EK E+EEK E + +E+ K++ + EK++E + ++
Sbjct: 507 -QEEKIREQEEMMQEQEEKMWEQEEKMCE---QEEKMQEQEEKMRRQEEKMREQEVRLRQ 562
Query: 232 EEIK 235
+E K
Sbjct: 563 QEEK 566
Score = 68.2 bits (165), Expect = 2e-11
Identities = 56/263 (21%), Positives = 131/263 (49%), Gaps = 20/263 (7%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRN--DDDEEEAARERRRRARQERLRQKQEEES 58
+++ E L +Q+ E+M + E+I + + EE+ + + RQE + ++EE+
Sbjct: 273 VEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKM 332
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQK--RLQEALE 116
Q +++ + + + E K E +++ E++ +E+R+++ ++ E
Sbjct: 333 RRQ--EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE 390
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
+ +E + I + + + + E + E+EE+ + ++E+ +E + Q+
Sbjct: 391 KIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKI---REQEKK 447
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQGE--EKGTKVQAKREKLQEDKPTFKKEEI 234
R+ EE +E +E +E+EEK +GE +G+ E+ K+Q + EK++ + +++E
Sbjct: 448 IREQEEKIREQEEMMQEQEEK-----MGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEK 502
Query: 235 K----DEKIKKDKEPKEEVKSFM 253
K +EKI++ +E +E + M
Sbjct: 503 KIREQEEKIREQEEMMQEQEEKM 525
Score = 33.5 bits (75), Expect = 0.53
Identities = 18/116 (15%), Positives = 52/116 (44%), Gaps = 1/116 (0%)
Query: 2 DDFERRRELRRQKREEM-RLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
+ + E+ +++ E+M E + + ++EE R + + R++ + +++EE +
Sbjct: 453 EKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 512
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALE 116
+ + ++ + EE E +++ E R +E R ++ +E ++
Sbjct: 513 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 92.4 bits (228), Expect = 1e-18
Identities = 106/479 (22%), Positives = 217/479 (45%), Gaps = 56/479 (11%)
Query: 5 ERRRELRRQKREEMRL-EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E +E + +E++RL E+E+ Q N D + + Q++L+ E + LG+
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQV--EADRLGKEL 271
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
V Q V + E N Q E E++ R+EE+ +QE E+ E +
Sbjct: 272 QSVSAKLQAQVEENEL-WNLLNQQQE--------EKMWRQEEK----IQEQEEKMCEQEL 318
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
I + + + + E + E+E+K ++E+ I E E + ++ WR E+
Sbjct: 319 KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEK--IREQEEKIREQEEKMWRQEEKI 376
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDK 243
+++D++ +E+EEE ++ Q E++ K+ + +K++E +++E +E ++++
Sbjct: 377 REQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQE--EEMWRQEE 434
Query: 244 EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEA 303
+ +E + D+++ EV+ + E K++ E R +E + Q E
Sbjct: 435 KIRELEEMMQDQEEKLREVEEKMQE-EEEKMQEQEEKIQR---------QEEKIQEQEEK 484
Query: 304 GKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE--- 360
R E+L ++ E + E E+ +Q+E E EE K +E+ K+ +EE+ R+QE
Sbjct: 485 TWRQEKLLKQ--EEKIWEQEEKMWRQEEKMWEQEE--KMQEQEEKMQRQEEKMREQEVRL 540
Query: 361 -EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEE 419
+ + K++E+E + +E+E R + +K + + G + TP L++E
Sbjct: 541 WQQEEKMQEQEVR---LQELEERLGKLGQKAELLGGAGRESGSQRLPTLTP---ILQVEL 594
Query: 420 RAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAE 478
+++ Q+ + L+QY +A + S K P+ S + A+
Sbjct: 595 KSQEAQSLQQQQDHYR------------GHLQQYVAAYQQLASGKEALPSCSSRKLRAK 641
Score = 57.8 bits (138), Expect = 3e-08
Identities = 57/253 (22%), Positives = 118/253 (46%), Gaps = 30/253 (11%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
+ + E R++ ++M + E+I Q E+E R+ +E+ + QE+E +
Sbjct: 332 EKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEE--E 389
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+ Q E + +E E D++ E R+E + + L+E ++ Q+E
Sbjct: 390 MWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEE- 448
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
L +MQ + E + E+EEK + ++E+ + +E +T WR +
Sbjct: 449 -------KLREVEEKMQEE--EEKMQEQEEKIQRQEEKIQEQEEKT---------WR--Q 488
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIK----DE 237
E + +EK E+EEK R E + E+ K+Q + EK+Q + +++E++ +E
Sbjct: 489 EKLLKQEEKIWEQEEKMWR---QEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEE 545
Query: 238 KIKKDKEPKEEVK 250
K+++ + +E++
Sbjct: 546 KMQEQEVRLQELE 558
Score = 55.8 bits (133), Expect = 1e-07
Identities = 49/228 (21%), Positives = 105/228 (46%), Gaps = 26/228 (11%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQ--RNDDDEEEAARERRRRARQERLRQK---QEE 56
+ + E R++ E+M + E+I Q + + EEE R+ + QE RQ+ ++E
Sbjct: 353 EKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQE 412
Query: 57 ESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALE 116
+ + + +++ + EE + +++ +E + EE + + +E ++
Sbjct: 413 KKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQ 472
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
RQ+E ++Q + E T ++EK ++E+ I E E ++
Sbjct: 473 RQEE---------------KIQE---QEEKTWRQEKLLKQEEK--IWEQEEKMWRQEEKM 512
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQE 224
W + EE +E +EK + +EEK + + Q EEK + + + ++L+E
Sbjct: 513 W-EQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEE 559
Score = 53.9 bits (128), Expect = 4e-07
Identities = 81/383 (21%), Positives = 165/383 (43%), Gaps = 49/383 (12%)
Query: 34 EEEAARERRRRARQERLRQ----------KQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 83
E EA E R+R +R + KQ +ESL +VT ++PD+EA
Sbjct: 68 EMEAYLENRKRRGTKRWDEDDDLEESEDSKQCKESLKRVTF--------TLPDDEAIEDA 119
Query: 84 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 143
+ V+ + + + +KR ++ E+ F + + P R+ TA+
Sbjct: 120 GVSHVKKNSDEV--------KSSFKKRQEKMNEKNYTFRKRVV---IKKPWLRLGEVTAQ 168
Query: 144 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE--ENKKEDKEKEEEEEEKPKRG 201
E E+ + + + K ++ D E N D+E +E+ E ++
Sbjct: 169 KRP-ENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLELYRNTITDEELKEKNAELQEKL 227
Query: 202 SIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTE 261
+ E++ E V+ + KL+ + +++++ E + KE + V + + + E
Sbjct: 228 RLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKE-LQSVSAKLQAQVEENE 286
Query: 262 VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEE 321
+ + + K+ E + +E + Q + EE R+ E E+
Sbjct: 287 LWNLLNQQQEEKMWRQEE---------KIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQ 337
Query: 322 FEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEK-RRLKEEIE 380
EK+++++ + + E++ RE+ K+ E+EE+ +QEE K+RE++EK + +EE+
Sbjct: 338 EEKIREQEDKMWRQEEKI---REQEEKIREQEEKMWRQEE---KIREQDEKIQEQEEEMW 391
Query: 381 RRRAEAAEKRQKMPEDGLSDDKK 403
R+ + E+ +K E +KK
Sbjct: 392 RQEEKIREQEEKRQEKMWRQEKK 414
Score = 32.0 bits (71), Expect = 1.5
Identities = 42/171 (24%), Positives = 81/171 (47%), Gaps = 19/171 (11%)
Query: 2 DDFERRRELRRQKREE---MRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES 58
D E+ RE+ + +EE M+ + E+I Q EE+ + + RQE+L KQEE+
Sbjct: 445 DQEEKLREVEEKMQEEEEKMQEQEEKIQRQ-----EEKIQEQEEKTWRQEKLL-KQEEKI 498
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE--RLARREERRQK---RLQE 113
Q ++ + + ++E K +++ +E + RL ++EE+ Q+ RLQE
Sbjct: 499 WEQ--EEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQE 556
Query: 114 ALERQKEFD---PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYE 161
ER + + A S+R+ T + K ++++S Q++ +
Sbjct: 557 LEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQD 607
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 92.4 bits (228), Expect = 1e-18
Identities = 106/479 (22%), Positives = 217/479 (45%), Gaps = 56/479 (11%)
Query: 5 ERRRELRRQKREEMRL-EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E +E + +E++RL E+E+ Q N D + + Q++L+ E + LG+
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQV--EADRLGKEL 271
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
V Q V + E N Q E E++ R+EE+ +QE E+ E +
Sbjct: 272 QSVSAKLQAQVEENEL-WNLLNQQQE--------EKMWRQEEK----IQEQEEKMCEQEL 318
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
I + + + + E + E+E+K ++E+ I E E + ++ WR E+
Sbjct: 319 KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEK--IREQEEKIREQEEKMWRQEEKI 376
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDK 243
+++D++ +E+EEE ++ Q E++ K+ + +K++E +++E +E ++++
Sbjct: 377 REQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQE--EEMWRQEE 434
Query: 244 EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEA 303
+ +E + D+++ EV+ + E K++ E R +E + Q E
Sbjct: 435 KIRELEEMMQDQEEKLREVEEKMQE-EEEKMQEQEEKIQR---------QEEKIQEQEEK 484
Query: 304 GKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE--- 360
R E+L ++ E + E E+ +Q+E E EE K +E+ K+ +EE+ R+QE
Sbjct: 485 TWRQEKLLKQ--EEKIWEQEEKMWRQEEKMWEQEE--KMQEQEEKMQRQEEKMREQEVRL 540
Query: 361 -EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEE 419
+ + K++E+E + +E+E R + +K + + G + TP L++E
Sbjct: 541 WQQEEKMQEQEVR---LQELEERLGKLGQKAELLGGAGRESGSQRLPTLTP---ILQVEL 594
Query: 420 RAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAE 478
+++ Q+ + L+QY +A + S K P+ S + A+
Sbjct: 595 KSQEAQSLQQQQDHYR------------GHLQQYVAAYQQLASGKEALPSCSSRKLRAK 641
Score = 57.8 bits (138), Expect = 3e-08
Identities = 57/253 (22%), Positives = 118/253 (46%), Gaps = 30/253 (11%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
+ + E R++ ++M + E+I Q E+E R+ +E+ + QE+E +
Sbjct: 332 EKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEE--E 389
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+ Q E + +E E D++ E R+E + + L+E ++ Q+E
Sbjct: 390 MWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEE- 448
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
L +MQ + E + E+EEK + ++E+ + +E +T WR +
Sbjct: 449 -------KLREVEEKMQEE--EEKMQEQEEKIQRQEEKIQEQEEKT---------WR--Q 488
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIK----DE 237
E + +EK E+EEK R E + E+ K+Q + EK+Q + +++E++ +E
Sbjct: 489 EKLLKQEEKIWEQEEKMWR---QEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEE 545
Query: 238 KIKKDKEPKEEVK 250
K+++ + +E++
Sbjct: 546 KMQEQEVRLQELE 558
Score = 55.8 bits (133), Expect = 1e-07
Identities = 49/228 (21%), Positives = 105/228 (46%), Gaps = 26/228 (11%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQ--RNDDDEEEAARERRRRARQERLRQK---QEE 56
+ + E R++ E+M + E+I Q + + EEE R+ + QE RQ+ ++E
Sbjct: 353 EKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQE 412
Query: 57 ESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALE 116
+ + + +++ + EE + +++ +E + EE + + +E ++
Sbjct: 413 KKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQ 472
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
RQ+E ++Q + E T ++EK ++E+ I E E ++
Sbjct: 473 RQEE---------------KIQE---QEEKTWRQEKLLKQEEK--IWEQEEKMWRQEEKM 512
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQE 224
W + EE +E +EK + +EEK + + Q EEK + + + ++L+E
Sbjct: 513 W-EQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEE 559
Score = 53.9 bits (128), Expect = 4e-07
Identities = 81/383 (21%), Positives = 165/383 (43%), Gaps = 49/383 (12%)
Query: 34 EEEAARERRRRARQERLRQ----------KQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 83
E EA E R+R +R + KQ +ESL +VT ++PD+EA
Sbjct: 68 EMEAYLENRKRRGTKRWDEDDDLEESEDSKQCKESLKRVTF--------TLPDDEAIEDA 119
Query: 84 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 143
+ V+ + + + +KR ++ E+ F + + P R+ TA+
Sbjct: 120 GVSHVKKNSDEV--------KSSFKKRQEKMNEKNYTFRKRVV---IKKPWLRLGEVTAQ 168
Query: 144 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE--ENKKEDKEKEEEEEEKPKRG 201
E E+ + + + K ++ D E N D+E +E+ E ++
Sbjct: 169 KRP-ENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRNTITDEELKEKNAELQEKL 227
Query: 202 SIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTE 261
+ E++ E V+ + KL+ + +++++ E + KE + V + + + E
Sbjct: 228 RLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKE-LQSVSAKLQAQVEENE 286
Query: 262 VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEE 321
+ + + K+ E + +E + Q + EE R+ E E+
Sbjct: 287 LWNLLNQQQEEKMWRQEE---------KIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQ 337
Query: 322 FEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEK-RRLKEEIE 380
EK+++++ + + E++ RE+ K+ E+EE+ +QEE K+RE++EK + +EE+
Sbjct: 338 EEKIREQEDKMWRQEEKI---REQEEKIREQEEKMWRQEE---KIREQDEKIQEQEEEMW 391
Query: 381 RRRAEAAEKRQKMPEDGLSDDKK 403
R+ + E+ +K E +KK
Sbjct: 392 RQEEKIREQEEKRQEKMWRQEKK 414
Score = 32.0 bits (71), Expect = 1.5
Identities = 42/171 (24%), Positives = 81/171 (47%), Gaps = 19/171 (11%)
Query: 2 DDFERRRELRRQKREE---MRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES 58
D E+ RE+ + +EE M+ + E+I Q EE+ + + RQE+L KQEE+
Sbjct: 445 DQEEKLREVEEKMQEEEEKMQEQEEKIQRQ-----EEKIQEQEEKTWRQEKLL-KQEEKI 498
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE--RLARREERRQK---RLQE 113
Q ++ + + ++E K +++ +E + RL ++EE+ Q+ RLQE
Sbjct: 499 WEQ--EEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQE 556
Query: 114 ALERQKEFD---PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYE 161
ER + + A S+R+ T + K ++++S Q++ +
Sbjct: 557 LEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQD 607
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 92.0 bits (227), Expect = 1e-18
Identities = 108/440 (24%), Positives = 191/440 (43%), Gaps = 22/440 (5%)
Query: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQE--EESLGQVTD 64
R E+ R E L AE+ +++ D +E+E +ER + ++ER ++ +E EE G+ +
Sbjct: 683 RGEMERPGEGEKEL-AEKEEWKKRDGEEQEQ-KEREQGHQKERNQEMEEGGEEEHGEGEE 740
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER---RQKRLQEALERQKEF 121
+ + + E K +VEG+ E ER ++EER +K +E + + E
Sbjct: 741 EEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGER--KKEERAGKEEKGEEEGDQGEGEE 798
Query: 122 DPTITDASLSLPSRRMQNDTAEN---ETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
+ T ++ E E E+EE+ E +E E EE E + ++ + +
Sbjct: 799 EETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEE-EEGEGK 857
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEK 238
EE ++ + E+E EE E GE +GEE+G + E E + + E ++E
Sbjct: 858 GEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 917
Query: 239 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPG-----GRASVDTK 293
K +E EE + + ++G E + GE + + G G +
Sbjct: 918 EGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEG 977
Query: 294 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 353
E EG + G+ EE GE E E E+ + + +E E + + EE EEE
Sbjct: 978 EGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEE 1037
Query: 354 EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGS 413
E + EE +++ EE +R +EE E E + ++ E+ D + +K +
Sbjct: 1038 EGEEEGEEREKEGEGEENRRNREEEEE----EEGKYQETGEEENERQDGEEYKKVSKIKG 1093
Query: 414 SLKIEERAEFLNKSVQKSSG 433
S+K + + KSV + G
Sbjct: 1094 SVKYGKHKTYQKKSVTNTQG 1113
Score = 79.7 bits (195), Expect = 6e-15
Identities = 102/437 (23%), Positives = 184/437 (42%), Gaps = 61/437 (13%)
Query: 10 LRRQKREEMRLE-AERIAYQRNDDDEE--EAARERRRRARQERLRQ-------------- 52
+++QK+++ E + A NDD +E E + + +A ++ + Q
Sbjct: 520 VQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAF 579
Query: 53 KQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF------LERLARREER 106
EE + + + E + N + ++E + N +V G + L A E
Sbjct: 580 SDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEG 639
Query: 107 RQKRLQEALERQK-EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEET 165
+ K + EA + + D T + S AE+ E+ EK E + R E+E
Sbjct: 640 KAKSVGEAEDGPEGRGDGTCEEGSSG----------AEHWQDEEREKGEKDKGRGEMERP 689
Query: 166 ETVTKSY-QKNDWRDAEENKKEDKEKE-----EEEEEKPKRGSIGENQGEEKGTKVQAKR 219
K +K +W+ + ++E KE+E E +E + G +GEE+ + +
Sbjct: 690 GEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEE 749
Query: 220 EKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRK---------------KGFTEVKS 264
EK E K + EE++ E+ K++ E K+E ++ + K +G E K
Sbjct: 750 EKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKE 809
Query: 265 QNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEK 324
+ GE +++ E R + +E EG + E G+ EE +GE E EE E
Sbjct: 810 EGGEVEGGEVE--EGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEG 867
Query: 325 LKQKQQ---EAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIER 381
++ ++ E E E + + E + EEE + +EE + + EEE + + +EE E
Sbjct: 868 EEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEE 927
Query: 382 RRAEAAEKR-QKMPEDG 397
E E+ + EDG
Sbjct: 928 GEGEGEEEEGEGEGEDG 944
Score = 58.5 bits (140), Expect = 2e-08
Identities = 97/427 (22%), Positives = 163/427 (38%), Gaps = 85/427 (19%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
++ E R E + + E E E +R +++EE E +E + +EEE G+
Sbjct: 799 EETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEE-GEGEEEEGEGK 857
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
++ E + EE + + EG+ E EE + +E E + E
Sbjct: 858 GEEEGE-EGEGEEEGEEGEGEGEEEEGEGEGE----------EEGEGEGEEEEGEGEGE- 905
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
+ E E E E K E E E E E + ++ + E
Sbjct: 906 ----------------EEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGE 949
Query: 182 ENKKEDKEKEEE-----EEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKD 236
E + E + +EEE EEE G GE +GEE+ + + + E+ +E+ EE +
Sbjct: 950 EEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEE-----GEEEGE 1004
Query: 237 EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAE 296
+ + + E +EE + ++ EV+ + GE G + E E
Sbjct: 1005 GEEEGEGEGEEEEEGEVE-----GEVEGEEGE-----------------GEGEEEEGEEE 1042
Query: 297 GAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQR 356
G + + G+ EE RR R E E EE K QE E E ++ E+
Sbjct: 1043 GEEREKEGEG-EENRRNREEEEEEE-----GKYQETGEEENE-----------RQDGEEY 1085
Query: 357 RKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMP-------EDGLSDDKKPFKCFT 409
+K + ++ + K K+ + + E+R KMP ++G S KK +
Sbjct: 1086 KKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKKFWNNVL 1145
Query: 410 PKGSSLK 416
P LK
Sbjct: 1146 PHYLELK 1152
Score = 43.5 bits (101), Expect = 5e-04
Identities = 70/301 (23%), Positives = 120/301 (39%), Gaps = 53/301 (17%)
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQG---EEKGTKVQAKREKLQEDKPTFKKEEIKDEK 238
EN D+ +E E ++ K +QG + T ++A + +E + +KE +D K
Sbjct: 540 ENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSD--EEVEIPEEKEGAEDSK 597
Query: 239 ----IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 294
+++ E EE +K TE+ S + +T K + +E G + D E
Sbjct: 598 GNGIEEQEVEANEENVKVHGGRKEKTEILSDD---LTDKAEVSEGKAKSVG--EAEDGPE 652
Query: 295 AEGAPQVEAG----KRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVL 350
G E G + ++ R +GE + E + + E L +E KKR+ +
Sbjct: 653 GRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQ 712
Query: 351 EEEEQRR-------------------KQEEADRKLREEE-------------EKRRLKEE 378
+E EQ ++EE DR+ EE+ E R KEE
Sbjct: 713 KEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEE 772
Query: 379 IERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTH 438
ER++ E A K +K E+G D+ + +G + EE E V++ G +
Sbjct: 773 GERKKEERAGKEEKGEEEG---DQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEE 829
Query: 439 Q 439
+
Sbjct: 830 E 830
>gi|148839339 nexilin (F actin binding protein) [Homo sapiens]
Length = 675
Score = 92.0 bits (227), Expect = 1e-18
Identities = 96/396 (24%), Positives = 182/396 (45%), Gaps = 36/396 (9%)
Query: 28 QRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV--NAQNSVPDEEAKTTTTN 85
QR ++ + ER+RR Q+ L +++ + L + +Q+E N EE +
Sbjct: 112 QRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLI 171
Query: 86 TQV-------EGDDEAAFLERLARREERRQKRLQEALE-RQKEFDPTITDAS-LSLPSRR 136
T V G + F + REE+ + + +E R +E P++ +A LSL
Sbjct: 172 TVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSL---- 227
Query: 137 MQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEE 196
+ +D E+E K+E + + EE E + Q+N + AEE ++ E+E+ E
Sbjct: 228 VMDDEIESEA--KKESLSPGKLKLTFEELE---RQRQENRKKQAEEEARKRLEEEKRAFE 282
Query: 197 KPKRGSIGENQGEEKGTKVQA--KREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMD 254
+ +R + E++ + K+ + KL+ +++ +DEK K ++E + ++ +
Sbjct: 283 EARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIE---E 339
Query: 255 RKKGFTEVKSQN--GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRR 312
KK F E + + K F PG + ++ +E E +R EE R+
Sbjct: 340 EKKAFAEARRNMVVDDDSPEMYKTISQEFLTPG-KLEINFEELLKQKMEEEKRRTEEERK 398
Query: 313 RRGETESEEFEKLKQKQQEAALELEELKKKRE-------ERRKVLEEEEQRRKQEEADRK 365
+ E E +EFE+L+Q+ E E E RE +R ++ + + K E+ +
Sbjct: 399 HKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIG-Q 457
Query: 366 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDD 401
L E+E +++++EE RRRA E +++ E+ +D
Sbjct: 458 LSEKEIQKKIEEERARRRAIDLEIKEREAENFHEED 493
Score = 88.2 bits (217), Expect = 2e-17
Identities = 122/493 (24%), Positives = 210/493 (42%), Gaps = 84/493 (17%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQV 62
D + + E ++ REE QR DE++ +E+ R R+ R+KQE + +
Sbjct: 30 DVKDKFEAMQRAREERN--------QRRSRDEKQRRKEQYIREREWN-RRKQEIKEMLAS 80
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD 122
D+ +V+++ E+A V+G F E +R+E ++KR +E +R+ E D
Sbjct: 81 DDEEDVSSKV----EKAYVPKLTGTVKG----RFAEMEKQRQEEQRKRTEEERKRRIEQD 132
Query: 123 PTITDASLSLPSRRMQNDTAEN-------ETTEKEEKSESRQERYEIEETETVTKSYQKN 175
L R++Q + A+ T E SE + I T KSY+ +
Sbjct: 133 --------MLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLI--TVVPVKSYKTS 182
Query: 176 D--WRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKV-----------QAKREKL 222
++ E+ +KE +EKE + E+ KR E + K K +AK+E L
Sbjct: 183 GKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESL 242
Query: 223 QED--KPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENT 280
K TF++ E + ++ +K + +E K + K+ F E + Q M ++ + ++T
Sbjct: 243 SPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQ----MVNEDEENQDT 298
Query: 281 FS-----RPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQ------ 329
RP G+ + +E E + + ++ EE RRR E E + F + ++
Sbjct: 299 AKIFKGYRP-GKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDS 357
Query: 330 -------QEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERR 382
+ L +L+ EE K EEE+RR +EE KL E K+E E+
Sbjct: 358 PEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEME------KQEFEQL 411
Query: 383 RAEAAEKRQKMPEDGLSDDKKPFKCFTPKGS------SLKIEERAEFLNKSVQKSSGVKS 436
R E E+ ++ GLS + + GS K E+ + K +QK +
Sbjct: 412 RQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEER 471
Query: 437 THQAAIVSKIDSR 449
+ AI +I R
Sbjct: 472 ARRRAIDLEIKER 484
Score = 77.8 bits (190), Expect = 2e-14
Identities = 91/409 (22%), Positives = 175/409 (42%), Gaps = 46/409 (11%)
Query: 31 DDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE- 89
D ++E +ER + +R+R +++ SL E + V D+E ++ +
Sbjct: 191 DLEKEREEKERIKYEEDKRIRYEEQRPSLK------EAKCLSLVMDDEIESEAKKESLSP 244
Query: 90 GDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEK 149
G + F E +R+E R+K+ +E ++ E + + + R+M N+ EN+ T K
Sbjct: 245 GKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEA----RRQMVNEDEENQDTAK 300
Query: 150 EEKS-ESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQG 208
K + + EE E + +K R AEE + E+E++ + +R + ++
Sbjct: 301 IFKGYRPGKLKLSFEEMERQRREDEK---RKAEEEARRRIEEEKKAFAEARRNMVVDDDS 357
Query: 209 EEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFM--DRKKGFTEVKSQN 266
E + +E L K EE+ +K++++K EE + K+ F +++ +
Sbjct: 358 PEMYKTIS--QEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEM 415
Query: 267 GEFM----THKLKHTENTFSRPGGRASVDTKEAEGA-------PQVEAGKRLEELRRRRG 315
GE T L + S+ K + + E K++EE R RR
Sbjct: 416 GEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRR 475
Query: 316 -------ETESEEFEKLKQKQQEAALELE-------ELKKKREERRKVLEEEEQRRKQEE 361
E E+E F + A + E +K + E+ K EEEEQRR +E+
Sbjct: 476 AIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQ 535
Query: 362 ADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTP 410
+ LR + E+R + ++++R E E+ + ++D++ + P
Sbjct: 536 --KLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAP 582
Score = 70.1 bits (170), Expect = 5e-12
Identities = 88/371 (23%), Positives = 161/371 (43%), Gaps = 58/371 (15%)
Query: 89 EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 148
+GD + F REER Q+R ++ +R+KE I + +RR Q + +
Sbjct: 28 KGDVKDKFEAMQRAREERNQRRSRDEKQRRKE--QYIREREW---NRRKQEIKEMLASDD 82
Query: 149 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQG 208
+E+ S ++ Y + T TV K + + E+ ++E++ K EEE K + I ++
Sbjct: 83 EEDVSSKVEKAYVPKLTGTV-----KGRFAEMEKQRQEEQRKRTEEERKRR---IEQDML 134
Query: 209 EEKGTKVQ---AKREKLQED--------------------------KPTFKKEEIKDEKI 239
E++ K+Q AKR + ED T K + E +
Sbjct: 135 EKR--KIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDL 192
Query: 240 KKDKEPKEEVKSFMDRKKGFTEVKSQNGE------FMTHKLKHTENTFSRPGGRASVDTK 293
+K++E KE +K D++ + E + E M +++ S G+ + +
Sbjct: 193 EKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFE 252
Query: 294 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQK---QQEAALELEELKKKREERRKVL 350
E E Q K+ EE R+R E E FE+ +++ + E + ++ K + L
Sbjct: 253 ELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKL 312
Query: 351 EEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF--KCF 408
EE R++ E +++ EEE +RR++EE ++A A +R + +D + K +
Sbjct: 313 SFEEMERQRREDEKRKAEEEARRRIEEE---KKAFAEARRNMVVDDDSPEMYKTISQEFL 369
Query: 409 TPKGSSLKIEE 419
TP + EE
Sbjct: 370 TPGKLEINFEE 380
Score = 58.5 bits (140), Expect = 2e-08
Identities = 90/399 (22%), Positives = 163/399 (40%), Gaps = 63/399 (15%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
EL RQ++E + +AE A +R E +RA +E RQ E+ Q T ++
Sbjct: 253 ELERQRQENRKKQAEEEARKR---------LEEEKRAFEEARRQMVNEDEENQDTAKIFK 303
Query: 69 NAQNSVPDEEAKTTTTNTQVEGDDEAAFLE-RLARREERRQKRLQEALERQKEFDPTITD 127
+ G + +F E RRE+ ++K +EA R +E +
Sbjct: 304 GYR-----------------PGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAE 346
Query: 128 ASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKED 187
A ++ + +D+ E T +E + EE + K + + R EE +K
Sbjct: 347 ARRNMV---VDDDSPEMYKTISQEFLTPGKLEINFEE---LLKQKMEEEKRRTEEERKHK 400
Query: 188 KEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKE 247
E E++E E+ + + GEE +E+ TF +E IK +
Sbjct: 401 LEMEKQEFEQ-----LRQEMGEE------------EEENETFGLSREYEELIKLKRSGSI 443
Query: 248 EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL 307
+ K+ K F ++ + + + K++ E R + +EAE + + +
Sbjct: 444 QAKNL---KSKFEKIGQLSEKEIQKKIE--EERARRRAIDLEIKEREAENFHEED---DV 495
Query: 308 EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLR 367
+ R+ E +K + ++ A EE +++R E +K+L + ++R+ + A +K R
Sbjct: 496 DVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKR 555
Query: 368 EEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 406
EEEE +EE AE ++ G KKP K
Sbjct: 556 EEEE----EEEGSIMNGSTAED-EEQTRSGAPWFKKPLK 589
Score = 54.3 bits (129), Expect = 3e-07
Identities = 61/288 (21%), Positives = 134/288 (46%), Gaps = 17/288 (5%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT-DQVE 67
E+ RQ+RE+ + +AE A +R +++++ A RR + + + S +T ++E
Sbjct: 316 EMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE 375
Query: 68 VNAQNSVP---DEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+N + + +EE + T + + + E E+L R+E ++ E +E++
Sbjct: 376 INFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQL-RQEMGEEEEENETFGLSREYEEL 434
Query: 125 I-TDASLSLPSRRMQN------DTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDW 177
I S S+ ++ +++ +E E +K E+ +R+ ++E E +++ + D
Sbjct: 435 IKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDD 494
Query: 178 RDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE 237
D +K + + K + + + + EE+ +++ +KL + F++ EI
Sbjct: 495 VDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIE--EQKLL--RMQFEQREIDAA 550
Query: 238 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNG-EFMTHKLKHTENTFSRP 284
KK +E +EE S M+ E ++++G + LK+T S P
Sbjct: 551 LQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEP 598
Score = 50.8 bits (120), Expect = 3e-06
Identities = 76/329 (23%), Positives = 134/329 (40%), Gaps = 81/329 (24%)
Query: 155 SRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTK 214
S++ + ++ V K+Y + ++K E ++ EE NQ + K
Sbjct: 5 SQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREER----------NQRRSRDEK 54
Query: 215 VQAKREKLQEDKPTFKKEEIK------DEKIKKDKEPKEEVKSFMDRKKG-FTEVKSQNG 267
+ K + ++E + +K+EIK DE+ K K V KG F E++ Q
Sbjct: 55 QRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQ 114
Query: 268 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEE------ 321
E + K TE R + ++ ++ + + +++E++ E+ SEE
Sbjct: 115 E---EQRKRTEEERKRRIEQDMLEKRKIQ-RELAKRAEQIEDINNTGTESASEEGDDSLL 170
Query: 322 ------------------FEKL-KQKQQEAALELEELKKKR-EERRKVLEE--------- 352
FE L K+++++ ++ EE K+ R EE+R L+E
Sbjct: 171 ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMD 230
Query: 353 ---------------------EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQ 391
EE R+++E +K EEE ++RL+EE +RA +RQ
Sbjct: 231 DEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEE---KRAFEEARRQ 287
Query: 392 KMPEDGLSDD-KKPFKCFTPKGSSLKIEE 419
+ ED + D K FK + P L EE
Sbjct: 288 MVNEDEENQDTAKIFKGYRPGKLKLSFEE 316
Score = 41.6 bits (96), Expect = 0.002
Identities = 45/202 (22%), Positives = 83/202 (41%), Gaps = 33/202 (16%)
Query: 264 SQNGEFMTHKLKHTENTFSRPGGRASVDTK-EAEGAPQVEAGKRL---EELRRRRGETES 319
SQ E + K T+ G+ V K EA + E +R E+ RR+
Sbjct: 5 SQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIRE 64
Query: 320 EEFEKLKQK---------QQEAALELEEL-----------------KKKREERRKVLEEE 353
E+ + KQ+ +++ + ++E+ K+++EE+RK EEE
Sbjct: 65 REWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE 124
Query: 354 EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGS 413
+RR +++ K + + E + E+IE E + +D L P K + G
Sbjct: 125 RKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSG- 183
Query: 414 SLKIEERAEFLNKSVQKSSGVK 435
K+++ E L K ++ +K
Sbjct: 184 --KMKKNFEDLEKEREEKERIK 203
Score = 41.6 bits (96), Expect = 0.002
Identities = 59/260 (22%), Positives = 108/260 (41%), Gaps = 43/260 (16%)
Query: 1 MDDFERRRELRRQKREEM-RLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
M++ +RR E R+ + EM + E E++ + +++EE E +E E L
Sbjct: 386 MEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEE-----------NETFGLSREYEEL 434
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
++ + A+N E + +++ E ER RR + + +EA +
Sbjct: 435 IKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEE---ERARRRAIDLEIKEREAENFHE 491
Query: 120 EFDPTITDASLS-LPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
E D + A S P N A E+ K+ +E+ IEE + + +++ R
Sbjct: 492 EDDVDVRPARKSEAPFTHKVNMKAR---FEQMAKAREEEEQRRIEEQKLLRMQFEQ---R 545
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKK----EEI 234
+ + ++ +E+EEEEE GS E++ E+ + P FKK +
Sbjct: 546 EIDAALQKKREEEEEEEGSIMNGSTAEDE------------EQTRSGAPWFKKPLKNTSV 593
Query: 235 KDEK-----IKKDKEPKEEV 249
D + +K EPK E+
Sbjct: 594 VDSEPVRFTVKVTGEPKPEI 613
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 88.6 bits (218), Expect = 1e-17
Identities = 79/361 (21%), Positives = 168/361 (46%), Gaps = 28/361 (7%)
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDD-----EAAFLERLARREERRQKRLQEALERQK 119
++E + ++ + E +K T+ ++E + E +E+ R ER ++R +E ER++
Sbjct: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERER 327
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
E + R + D + T E++ + ++R E +S +N R
Sbjct: 328 EREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRE-----RSSDRNKDRS 382
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKD--E 237
K D+E+E E E + +R E + E + + + + + ++DK ++E+ +D E
Sbjct: 383 RSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYE 442
Query: 238 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEA-- 295
+ K +++ +E+ ++ +R K + E++ + K E R + + KE
Sbjct: 443 RRKLERKLREKEAAYQERLKNW-EIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLE 501
Query: 296 -----EGAPQVEAGKRLEE-LRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 349
P+ G L++ LR R E E++E ++ ++K+ ELEE++++
Sbjct: 502 DYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKE-----ELEEIRQRLLAEGHP 556
Query: 350 LEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFT 409
+ E +R ++EA+R+ + + ++ EE E + E EKR++ E+ ++KP C
Sbjct: 557 DPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKP--CLK 614
Query: 410 P 410
P
Sbjct: 615 P 615
Score = 86.7 bits (213), Expect = 5e-17
Identities = 86/355 (24%), Positives = 151/355 (42%), Gaps = 52/355 (14%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
+ R+E+ +++RE R E ER +R + E E RER + +ER R++ + + D
Sbjct: 300 KERQEIEKERRERER-ERERERERREREREREREREREKEKERERERERDRDRDRTKERD 358
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ ++ D E + + +++ ER RE R++ + ER++E +
Sbjct: 359 RDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERE-- 416
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE----ETETVTKSYQKNDWRDA 180
R + + +++ ++EE E ER ++E E E + KN W
Sbjct: 417 --------REREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKN-WEIR 467
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIK 240
E K + EKE E EE+ +R E E K K + D P + + +++
Sbjct: 468 ERKKTREYEKEAEREEERRR----EMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRL- 522
Query: 241 KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 300
+D+E KE DRK+ E++ + AEG P
Sbjct: 523 RDRE-KEMEADERDRKREKEELEEIRQRLL------------------------AEGHPD 557
Query: 301 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQ 355
+A EL+R E E ++KQ + E+ E EE ++K E+R + +EEEE+
Sbjct: 558 PDA-----ELQRMEQEAERRRQPQIKQ-EPESEEEEEEKQEKEEKREEPMEEEEE 606
Score = 77.0 bits (188), Expect = 4e-14
Identities = 85/375 (22%), Positives = 160/375 (42%), Gaps = 38/375 (10%)
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQ-----VEGDDEAAFLERLARREERRQKRLQEALERQK 119
+V+ + + + +AK +N V DDE A E RR++ + ++ +
Sbjct: 160 KVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYS 219
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEI-----------EETETV 168
+ L+ PS+ ++ + +K+EK E R+ + E+ +
Sbjct: 220 --------SELNAPSQ----ESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAI 267
Query: 169 TKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPT 228
K D E +K D K+ EEE+ K E + E + + + +RE+ + ++
Sbjct: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERER 327
Query: 229 FKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRA 288
++ E + EK +K++E + E DR K + + + + + ++ R R
Sbjct: 328 EREREREREK-EKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSRE 386
Query: 289 SVDTKEAEGAPQVEAGKRLEELRRRRGETESE---EFEKLKQKQQEAALELEELKKKREE 345
+E E + E + E R R E E E E E+ K K+++ + E+ ++R+
Sbjct: 387 KSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKL 446
Query: 346 RRKVLEEE----EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDD 401
RK+ E+E E+ + E +RK E EK +EE RR KR K + DD
Sbjct: 447 ERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDD 506
Query: 402 KKPFKCFTPKGSSLK 416
+ K + +GS+L+
Sbjct: 507 RDDPKYY--RGSALQ 519
Score = 65.9 bits (159), Expect = 1e-10
Identities = 82/413 (19%), Positives = 169/413 (40%), Gaps = 30/413 (7%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
K E L A R+ + +++ + + Q + +++ S G + N
Sbjct: 135 KEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEE 194
Query: 74 VPDEEAKTTTTNTQVEGDDEAAFLERLAR----------REERRQKRLQEALERQKEFDP 123
DEE K + ++G E E + +++K +E + R+ P
Sbjct: 195 ALDEETKRR--DQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAP 252
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
I ++ + E S+ R ++EE + +K R E
Sbjct: 253 LIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKG-----KKEKERQEIEK 307
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDK 243
++ ++E+E E E + + + E+ + + +RE+ ++ KE +D ++D+
Sbjct: 308 ERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDR 367
Query: 244 EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEA 303
+ E S ++ + + KS++ E + + E R R +E E + E
Sbjct: 368 DRDRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREK 427
Query: 304 GKRLEELRRRRGETESEEFEKLKQK--QQEAAL-------ELEELKKKREERRKVLEEEE 354
K+ + R E ++ E KL++K ++EAA E+ E KK RE ++ EEE
Sbjct: 428 DKKRD---REEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEE 484
Query: 355 QRRKQEEADRKLRE-EEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 406
+RR+ + ++L+E E+ +++ + R A +KR + E + D++ K
Sbjct: 485 RRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRK 537
Score = 38.5 bits (88), Expect = 0.017
Identities = 61/281 (21%), Positives = 108/281 (38%), Gaps = 60/281 (21%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLR---------- 51
++E+ E ++R EM EA+R+ D DD+ + + R A Q+RLR
Sbjct: 474 EYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADE 533
Query: 52 --QKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQK 109
+K+E+E L ++ ++ PD +A+ + E + + EE +K
Sbjct: 534 RDRKREKEELEEIRQRLLAEGH---PDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEK 590
Query: 110 -----RLQEALERQKE------FDPTITDASLSLPSRRMQNDTAENETTEKE-------- 150
+ +E +E ++E PT+ S S PS + A T E
Sbjct: 591 QEKEEKREEPMEEEEEPEQKPCLKPTLRPIS-SAPSVSSASGNATPNTPGDESPCGIIIP 649
Query: 151 -EKSESRQERYEIEETETVTKSY-------QKNDWR------DAEENKKEDKEKEE---- 192
E S +Q+ E ++ Q N + D+ NK ED++ ++
Sbjct: 650 HENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRK 709
Query: 193 ------EEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKP 227
+ E K + G EEK +++ EK+ KP
Sbjct: 710 RKLVPLDYGEDDKNATKGTVNTEEKRKHIKSLIEKIPTAKP 750
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 88.2 bits (217), Expect = 2e-17
Identities = 87/450 (19%), Positives = 200/450 (44%), Gaps = 32/450 (7%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
DD + E + + ++ + E +A + +++EEE + +++ Q+ +Q ++ +
Sbjct: 56 DDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEE 115
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+ D+ + + + P E + + + DD+ L + A+ + ++ + + E ++
Sbjct: 116 LEDKDSKSKKTAKPKVEMYSGS-----DDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN 170
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEK-EEKSESRQERYEIEETETVTKSYQKNDWRDA 180
I + S S +++ E + K ++K++ + IE + K
Sbjct: 171 SKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQ 230
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQ---EDKPTFKKEEIKDE 237
++ +K+++E+++ +EEK K + E + E G K Q+K+++ Q E++ K +
Sbjct: 231 KKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTG 290
Query: 238 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEG 297
I +E E + D +G + K + + G KE +
Sbjct: 291 VIPASEEKAETPTAAEDDNEGDKKKKDK----------------KKKKGEKEEKEKEKKK 334
Query: 298 APQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRR 357
P K ++E + EE E+ K++++E LEEL+ KR+E ++ +E+ +R+
Sbjct: 335 GPSKATVKAMQEALAKL----KEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERK 390
Query: 358 KQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKI 417
KQ+E +RK R ++E + L + RA A + + G+ + P K PK +
Sbjct: 391 KQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGV---EVPSKDSLPKKRPIYE 447
Query: 418 EERAEFLNKSVQKSSGVKSTHQAAIVSKID 447
+++ + + + ++ +S A V ++
Sbjct: 448 DKKRKKIPQQLESKEVSESMELCAAVEVME 477
Score = 87.4 bits (215), Expect = 3e-17
Identities = 103/455 (22%), Positives = 209/455 (45%), Gaps = 50/455 (10%)
Query: 15 REEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSV 74
++++ L+A + +E+ ++ + + ++E+ +Q +E+ + + +++ + AQ
Sbjct: 14 KDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIK 73
Query: 75 PDEE--AKTTTTNTQVEG-----------------DDEAAFLERLARREERRQKRLQEAL 115
D E A T N + E DD + E L ++ + +K + +
Sbjct: 74 ADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDS--EELEDKDSKSKKTAKPKV 131
Query: 116 ERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKN 175
E D D LP + N+ + E+ E ++ I+E + S +
Sbjct: 132 EMYSGSDDD--DDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKK--IKERSRINSSGESG 187
Query: 176 DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIK 235
D +++E + K +++ ++ KP N+ ++ K++ +K E K +K+ +
Sbjct: 188 D--ESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDE 245
Query: 236 DE-KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFM--THKLKHTENTFSRPGGRASVDT 292
++ K++K KE KEE+++ KK ++ K +F T K K T +T P +T
Sbjct: 246 EKAKLRKLKE-KEELET---GKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAET 301
Query: 293 KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE 352
A E K+ ++ ++++GE E +E EK K + ++E K L+E
Sbjct: 302 PTA-AEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAK-------LKE 353
Query: 353 EEQRRKQEEADR--KLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTP 410
EE+R+K+EE +R +L E E KR+ +E +E+ + E ++++K ++ L KK K T
Sbjct: 354 EEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERL---KKEGKLLTK 410
Query: 411 KGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSK 445
S + RAE K +Q + GV+ + ++ K
Sbjct: 411 --SQREARARAEATLKLLQ-AQGVEVPSKDSLPKK 442
Score = 75.1 bits (183), Expect = 2e-13
Identities = 99/483 (20%), Positives = 203/483 (42%), Gaps = 86/483 (17%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLR---QKQEEES 58
+D E + + ++ + + E + +DDD + ++ + +A++ + +++E++
Sbjct: 111 NDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN 170
Query: 59 LGQVTDQVEVNAQNSVPDE------------EAKTTTTNTQVEG---DDEAAF-----LE 98
++ ++ +N+ DE + + +E DD+A+F +
Sbjct: 171 SKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQ 230
Query: 99 RLARREERRQKRLQEA------LERQKEFDPTITDASLSLPS-RRMQNDTAENETTEKEE 151
+ A ++ER +K+ E L+ ++E + D S S R+ + +T +++ T
Sbjct: 231 KKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTG 290
Query: 152 KSESRQERYEIEETETVTKSYQKNDWRDAEENKK--EDKEKEEEEEEKPKRGSIGENQGE 209
+ +E+ ET T + + D + ++ KK E +EKE+E+++ P + ++ Q
Sbjct: 291 VIPASEEK---AETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEA 347
Query: 210 EKGTKVQAKREKLQEDKPTFKKEEI--------------KDEKIKKDKEPKEEVKSFMDR 255
K + +R+K +E++ + EE+ ++ K +K+KE KE +K
Sbjct: 348 LAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLK----- 402
Query: 256 KKGFTEVKSQNGEFM----THKLKHTENTF-----SRPGGRASVDTKEAEGAPQVEAGKR 306
K+G KSQ T KL + S P R + K+ + PQ K
Sbjct: 403 KEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKE 462
Query: 307 LEELRR-------------RRGET-------ESEEFEKLKQKQQEAALELEELKKKREER 346
+ E + ET E E+ E EA EE +K +
Sbjct: 463 VSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNK 522
Query: 347 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED---GLSDDKK 403
+ +E ++EE + + +EE + +EE E +E E+ +K+ ++ G + DKK
Sbjct: 523 VHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKK 582
Query: 404 PFK 406
P K
Sbjct: 583 PSK 585
Score = 74.7 bits (182), Expect = 2e-13
Identities = 85/409 (20%), Positives = 181/409 (44%), Gaps = 63/409 (15%)
Query: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 66
++E R+KR+E + + ++ ++EE ++ +++Q+ ++K EEE+ V +V
Sbjct: 235 KKERERKKRDEEKAKLRKLK------EKEELETGKKDQSKQKESQRKFEEET---VKSKV 285
Query: 67 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT 126
V+ +P E K T T E D+E +++++++K +E E++K+ P+
Sbjct: 286 TVDT-GVIPASEEKAETP-TAAEDDNEGD----KKKKDKKKKKGEKEEKEKEKKKGPSKA 339
Query: 127 DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE 186
+ MQ A+ + E+ +K E + +EE E K ++ + E K++
Sbjct: 340 TV------KAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQK 393
Query: 187 DKEKEEEEEEKPKRGSIGENQG-----------EEKGTKVQAKREKLQEDKPTFKKEEIK 235
+KE++E +++ K + + + + +G +V +K + L + +P + E+ K
Sbjct: 394 EKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSK-DSLPKKRPIY--EDKK 450
Query: 236 DEKIKKDKEPKEEVKSFM-------------DRKKGFTEVKSQNGEFMT-------HKLK 275
+KI + E KE +S ++++ V+ + E +
Sbjct: 451 RKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMA 510
Query: 276 HTENTFSRPGGRASVDTKE-----AEGAPQVEAGKRLEELRRRRGETESEEFEKLKQK-- 328
E T G + ++ KE E + E + EE GE+E E ++ +K
Sbjct: 511 SDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVS 570
Query: 329 -QQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLK 376
++++ L++ K + ++ R K+E A K + EKRRL+
Sbjct: 571 DEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLE 619
Score = 72.0 bits (175), Expect = 1e-12
Identities = 65/285 (22%), Positives = 131/285 (45%), Gaps = 25/285 (8%)
Query: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 66
+ E RQKREE + +EE +E+R R +Q+ +K+ + G++ +
Sbjct: 352 KEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKS 411
Query: 67 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARR----EERRQKRLQEALERQKEFD 122
+ A+ A+ T Q +G E + L ++ E++++K++ + LE ++ +
Sbjct: 412 QREAR-----ARAEATLKLLQAQGV-EVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSE 465
Query: 123 PTITDASLSLPSRRMQNDTAENETT-------EKEEKSESRQERYEIEETETVTKSYQKN 175
A++ + M+ E E T E+E+ ++ + +E ++ T+ + N
Sbjct: 466 SMELCAAVEV----MEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGN 521
Query: 176 DWR-DAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEI 234
+ +EN +E++E+EEEEEE + E +GE +G++ + EK+ ++K + K
Sbjct: 522 KVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGK---T 578
Query: 235 KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN 279
D+K K+ E S DR K +L+H++N
Sbjct: 579 LDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKN 623
Score = 53.9 bits (128), Expect = 4e-07
Identities = 62/302 (20%), Positives = 127/302 (42%), Gaps = 25/302 (8%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDE--EEAARERRRRARQERLRQKQEEESLGQV 62
+R EL +++EE RLE E+ ++ + E E +E + + +R + + E +L +
Sbjct: 367 KRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLL 426
Query: 63 TDQ-VEVNAQNSVPD-----EEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALE 116
Q VEV +++S+P E+ K Q+E + + +E A E +++ +
Sbjct: 427 QAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEV-----MEQGVP 481
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
++E P + +D + E+ EK E + E++E + ++ +
Sbjct: 482 EKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEE 541
Query: 177 WRDAEENKKEDKEKE------EEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFK 230
D E ++E++E E +EE+EK ++K +K + + D K
Sbjct: 542 EEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTK 601
Query: 231 KEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMT------HKLKHTENTFSRP 284
+E D+ ++ ++ + E ++ +K + G T KL+HT
Sbjct: 602 EERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGEA 661
Query: 285 GG 286
GG
Sbjct: 662 GG 663
Score = 46.6 bits (109), Expect = 6e-05
Identities = 69/310 (22%), Positives = 128/310 (41%), Gaps = 56/310 (18%)
Query: 181 EENKKEDKEKEEEEEE---KPKRGSIGENQGEEKGTKVQAKREKLQED------------ 225
++NK ED K++ + + G+ + E + +K + K+EK ++D
Sbjct: 5 QKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64
Query: 226 -----------------KPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGE 268
KPT EE K KK K K + +SF D E K +
Sbjct: 65 LSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSK 124
Query: 269 FMTHKLK-------HTENTFS----RPGGRASVDTKEAEGAPQVE-AGKRLEELRR--RR 314
T K K ++ F+ + G+A K+ +G+ + E K+++E R
Sbjct: 125 -KTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSS 183
Query: 315 GET--ESEEF-----EKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLR 367
GE+ ES+EF + K ++ + +E + + K+ +++ +++E +RK R
Sbjct: 184 GESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKR 243
Query: 368 EEEEK--RRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLN 425
+EE+ R+LKE+ E + + +QK + ++ K G EE+AE
Sbjct: 244 DEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPT 303
Query: 426 KSVQKSSGVK 435
+ + G K
Sbjct: 304 AAEDDNEGDK 313
Score = 32.3 bits (72), Expect = 1.2
Identities = 23/119 (19%), Positives = 55/119 (46%), Gaps = 5/119 (4%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
+DD+E ++ E + +++EEE E + +E + + E S G
Sbjct: 503 LDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEG 562
Query: 61 QVTDQV---EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERR--QKRLQEA 114
D+ E ++ ++ + +K +++++ + DD+ ER + +RR ++RL+ +
Sbjct: 563 DEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHS 621
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 86.3 bits (212), Expect = 7e-17
Identities = 101/449 (22%), Positives = 193/449 (42%), Gaps = 52/449 (11%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQ 65
+R ELR ++ + + I + D EE++ + +++ ++ ++K V ++
Sbjct: 1092 KRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVI-----VKEK 1146
Query: 66 VEVNAQNSVPDEEAK-TTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ + S ++A T+++++ +E DD+ + E + ++ + L F +
Sbjct: 1147 KRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQS 1206
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184
D +LS +D +++ + E + + EI+ + + +D + EE K
Sbjct: 1207 SGDEALSKSVPVTVDD--DDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDD--EPEEGK 1262
Query: 185 KEDKEKEEEE--EEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKD 242
K ++ EE +E+ K E+ + + +K R +L K T E +EK K
Sbjct: 1263 KRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKP 1322
Query: 243 KEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE 302
KE KE VK RK V S++ E ++ F G V E E P+
Sbjct: 1323 KEHKE-VKGRNRRK-----VSSEDSE---------DSDFQESGVSEEVSESEDEQRPRTR 1367
Query: 303 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE- 361
+ K+ E +R + ++ ++K ++ ++ +++ EE+ + EEEE+ ++EE
Sbjct: 1368 SAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEED 1427
Query: 362 -------------------ADRKLREEEEKRRLKEEIERRR--AEAAEKRQKMPEDGLSD 400
D KLR E + LKEE ERR+ AE +R+K+ E +
Sbjct: 1428 ENDDSKSPGKGRKKIRKILKDDKLRTETQ-NALKEEEERRKRIAEREREREKLREVIEIE 1486
Query: 401 DKKPFKCFTPKGSSLKIEERAEFLNKSVQ 429
D P KC P + L ++E E VQ
Sbjct: 1487 DASPTKC--PITTKLVLDEDEETKEPLVQ 1513
Score = 57.0 bits (136), Expect = 4e-08
Identities = 86/436 (19%), Positives = 184/436 (42%), Gaps = 64/436 (14%)
Query: 21 EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNA---QNSVPDE 77
E ++++ D+ ++ + +L + ++ E++ Q +D E+ A + S
Sbjct: 649 EKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSH 708
Query: 78 EAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP----TITDASLSLP 133
+ + T ++ + + + + ++ + KR +++ +FD + + +S
Sbjct: 709 SSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKK 768
Query: 134 SRRMQNDTAENETT-EKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEE 192
R+ Q++++ ++ EKE KS S+ I T K D+ E++K K+ +
Sbjct: 769 KRQTQSESSNYDSELEKEIKSMSK-----IGAARTTKKRIPNTKDFDSSEDEKHSKKGMD 823
Query: 193 EEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIK--KDKEPKEEVK 250
+ K + S ++G+ A+R++ +E + + KD I +D+ PK++
Sbjct: 824 NQGHKNLKTS-------QEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQA 876
Query: 251 SFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEE- 309
S S +G KL E +F+ R +TKE + + K++++
Sbjct: 877 S-----------ASTDG---VDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDG 922
Query: 310 --------LRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 361
L++ + + SE+ +K +K E E KK + ++KV++ E+Q +
Sbjct: 923 LSDIAEKFLKKDQSDETSEDDKKQSKKGTE------EKKKPSDFKKKVIKMEQQYESSSD 976
Query: 362 ADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERA 421
KL E EE + I K ++G +D +K K K +S K +E +
Sbjct: 977 GTEKLPEREEICHFPKGI------------KQIKNGTTDGEKKSKKIRDK-TSKKKDELS 1023
Query: 422 EFLNKSVQKSSGVKST 437
++ KS K S+
Sbjct: 1024 DYAEKSTGKGDSCDSS 1039
Score = 56.2 bits (134), Expect = 8e-08
Identities = 72/357 (20%), Positives = 143/357 (40%), Gaps = 67/357 (18%)
Query: 30 NDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE 89
+DDD+ + ++ E ++ + G D+ E + + +T N +
Sbjct: 1222 DDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPE--------EGKKRTGKQNEENP 1273
Query: 90 GDDEA---AFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENET 146
GD+EA E + EE ++ R + L R K T++D E +T
Sbjct: 1274 GDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKL---TVSDGESG----------EEKKT 1320
Query: 147 TEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGEN 206
KE K + R ++ ++ +Q++ E E ++++ K+ + EN
Sbjct: 1321 KPKEHKEVKGRNRRKVSSEDSEDSDFQESG---VSEEVSESEDEQRPRTRSAKKAELEEN 1377
Query: 207 QGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN 266
Q K K + +R K+QED + K ++E+ +K++E +EE +
Sbjct: 1378 QRSYKQKK-KRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEE--------------- 1421
Query: 267 GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK 326
+ + EN S+ G+ G ++ + ++LR EE E+ K
Sbjct: 1422 -----EEEEEDENDDSKSPGK---------GRKKIRKILKDDKLRTETQNALKEEEERRK 1467
Query: 327 QKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRK--LREEEEKRRLKEEIER 381
+ + E +++RE+ R+V+E E+ + K L E+EE + ++ R
Sbjct: 1468 R--------IAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHR 1516
Score = 43.1 bits (100), Expect = 7e-04
Identities = 79/405 (19%), Positives = 153/405 (37%), Gaps = 95/405 (23%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
++ + D K+T + ++ RE++R K L ++ +++ D S
Sbjct: 1019 KDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQ-------DCSS 1071
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEK 190
S + + N + ++ ++ E R ER + + + DAEE+ +++K+K
Sbjct: 1072 SDTEKYSMKEDGCNSSDKRLKRIELR-ERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKK 1130
Query: 191 EEEEEEKPK-----------------------------------RGSIGENQGEEKGTKV 215
++ K K + SIGE +E+ K+
Sbjct: 1131 KQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQ--KI 1188
Query: 216 QAKREKLQEDKPTFKKEEIKDEKIKK-----------DKEPK---------EEVKSFMDR 255
+ E L T + DE + K D +P+ EE+K+ +
Sbjct: 1189 KPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSS 1248
Query: 256 -KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK------RLE 308
+ G ++ + + G+ T K ++ EN PG + + +E E K RL
Sbjct: 1249 DEDGSSDDEPEEGKKRTGK-QNEEN----PGDEEAKNQVNSESDSDSEESKKPRYRHRLL 1303
Query: 309 ELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE-----------RRKVLEEEEQRR 357
+ + ES E +K K K+ + K E+ +V E E+++R
Sbjct: 1304 RHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQR 1363
Query: 358 KQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 402
+ + +K EE +R K++ +RRR K+ ED S++K
Sbjct: 1364 PRTRSAKKAELEENQRSYKQKKKRRRI-------KVQEDSSSENK 1401
Score = 41.2 bits (95), Expect = 0.003
Identities = 24/113 (21%), Positives = 58/113 (51%), Gaps = 5/113 (4%)
Query: 5 ERRRELR-RQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E +R + ++KR ++++ + + +++ +EEE +E +E ++++E +
Sbjct: 1376 ENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSP 1435
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALE 116
+ + + D++ +T T N E ++ +R+A RE R+K L+E +E
Sbjct: 1436 GKGRKKIRKILKDDKLRTETQNALKEEEERR---KRIAEREREREK-LREVIE 1484
Score = 35.4 bits (80), Expect = 0.14
Identities = 80/430 (18%), Positives = 165/430 (38%), Gaps = 49/430 (11%)
Query: 19 RLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEE 78
RL ++ A D ++ + +E+ + + R + +E+S T + Q+ + D
Sbjct: 869 RLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCK-KVQDGLSDIA 927
Query: 79 AKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSR--- 135
K + E ++ + E+++ ++ + + ++ + +D + LP R
Sbjct: 928 EKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEI 987
Query: 136 --------RMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKED 187
+++N T + E K+ + ++ +++ E+ ++ KS K D D+ E+KK
Sbjct: 988 CHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDEL--SDYAEKSTGKGDSCDSSEDKKSK 1045
Query: 188 KEKEEEEEEK--------PKRGSIGENQGEEKGTK--------VQAKREKLQEDKPTFKK 231
E+++ KR + E+ K + KR +L+E + K
Sbjct: 1046 NGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSK 1105
Query: 232 EEIK---------DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFS 282
K D + + K++ ++ +K + K +N + K K + T S
Sbjct: 1106 RNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSS 1165
Query: 283 RPGGRASVDTKE-AEGAPQVEAGKRLEE---LRRRRGETESEEFEKLKQKQQEAALELEE 338
D EG+ + K + E L G +S E L K ++ ++
Sbjct: 1166 SSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEAL-SKSVPVTVDDDD 1224
Query: 339 LKKKREER--RKVLEEEEQRRKQEEADRKLREEEE---KRRLKEEIERRRAEAAEKRQKM 393
E R +K+L EE + + D +E E KR K+ E E A+ +
Sbjct: 1225 DDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNS 1284
Query: 394 PEDGLSDDKK 403
D S++ K
Sbjct: 1285 ESDSDSEESK 1294
Score = 33.5 bits (75), Expect = 0.53
Identities = 75/368 (20%), Positives = 142/368 (38%), Gaps = 46/368 (12%)
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQK-RLQEALER 117
L Q TD E+++ + +A + V D + A LA E+ + R +A+ +
Sbjct: 336 LKQATDNSEISSATKLRQLKAFKS-----VLADIKKA---HLALEEDLNSEFRAMDAVNK 387
Query: 118 QKEF-DPTITDASLSLPSRRMQNDTA-ENETTEKEEKSESRQERYEIEETETVTKSYQKN 175
+K + + DA +R+ + A E + K E SR++ + V Q+
Sbjct: 388 EKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRT 447
Query: 176 DWRDAEENKKEDKEKEEEEEEKPKR-----------GSIGENQGEEKGTKVQAKRE-KLQ 223
+ E+KK D+++E + E S+ E+ E T ++ + Q
Sbjct: 448 NKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQ 507
Query: 224 EDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKL--KHTENTF 281
D + ++E++ +K + K D + G +KS+ +T +L K T +
Sbjct: 508 GDGSSGTEQEVESSSVKLNISSK-------DNRGG---IKSKTTAKVTKELYVKLTPVSL 557
Query: 282 SR---PGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEE 338
S G ++ +G +LE+ + +++E + E +L LEE
Sbjct: 558 SNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHL-----VENEVSLLLEE 612
Query: 339 LKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGL 398
+R R K RR E +EE +E ++ +K ++ D
Sbjct: 613 SDLRRSPRVKT---TPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSA 669
Query: 399 SDDKKPFK 406
D+ KP K
Sbjct: 670 IDNPKPNK 677
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 86.3 bits (212), Expect = 7e-17
Identities = 101/449 (22%), Positives = 193/449 (42%), Gaps = 52/449 (11%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQ 65
+R ELR ++ + + I + D EE++ + +++ ++ ++K V ++
Sbjct: 1130 KRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVI-----VKEK 1184
Query: 66 VEVNAQNSVPDEEAK-TTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ + S ++A T+++++ +E DD+ + E + ++ + L F +
Sbjct: 1185 KRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQS 1244
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184
D +LS +D +++ + E + + EI+ + + +D + EE K
Sbjct: 1245 SGDEALSKSVPVTVDD--DDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDD--EPEEGK 1300
Query: 185 KEDKEKEEEE--EEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKD 242
K ++ EE +E+ K E+ + + +K R +L K T E +EK K
Sbjct: 1301 KRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKP 1360
Query: 243 KEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE 302
KE KE VK RK V S++ E ++ F G V E E P+
Sbjct: 1361 KEHKE-VKGRNRRK-----VSSEDSE---------DSDFQESGVSEEVSESEDEQRPRTR 1405
Query: 303 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE- 361
+ K+ E +R + ++ ++K ++ ++ +++ EE+ + EEEE+ ++EE
Sbjct: 1406 SAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEED 1465
Query: 362 -------------------ADRKLREEEEKRRLKEEIERRR--AEAAEKRQKMPEDGLSD 400
D KLR E + LKEE ERR+ AE +R+K+ E +
Sbjct: 1466 ENDDSKSPGKGRKKIRKILKDDKLRTETQ-NALKEEEERRKRIAEREREREKLREVIEIE 1524
Query: 401 DKKPFKCFTPKGSSLKIEERAEFLNKSVQ 429
D P KC P + L ++E E VQ
Sbjct: 1525 DASPTKC--PITTKLVLDEDEETKEPLVQ 1551
Score = 57.0 bits (136), Expect = 4e-08
Identities = 86/436 (19%), Positives = 184/436 (42%), Gaps = 64/436 (14%)
Query: 21 EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNA---QNSVPDE 77
E ++++ D+ ++ + +L + ++ E++ Q +D E+ A + S
Sbjct: 687 EKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSH 746
Query: 78 EAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP----TITDASLSLP 133
+ + T ++ + + + + ++ + KR +++ +FD + + +S
Sbjct: 747 SSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKK 806
Query: 134 SRRMQNDTAENETT-EKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEE 192
R+ Q++++ ++ EKE KS S+ I T K D+ E++K K+ +
Sbjct: 807 KRQTQSESSNYDSELEKEIKSMSK-----IGAARTTKKRIPNTKDFDSSEDEKHSKKGMD 861
Query: 193 EEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIK--KDKEPKEEVK 250
+ K + S ++G+ A+R++ +E + + KD I +D+ PK++
Sbjct: 862 NQGHKNLKTS-------QEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQA 914
Query: 251 SFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEE- 309
S S +G KL E +F+ R +TKE + + K++++
Sbjct: 915 S-----------ASTDG---VDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDG 960
Query: 310 --------LRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 361
L++ + + SE+ +K +K E E KK + ++KV++ E+Q +
Sbjct: 961 LSDIAEKFLKKDQSDETSEDDKKQSKKGTE------EKKKPSDFKKKVIKMEQQYESSSD 1014
Query: 362 ADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERA 421
KL E EE + I K ++G +D +K K K +S K +E +
Sbjct: 1015 GTEKLPEREEICHFPKGI------------KQIKNGTTDGEKKSKKIRDK-TSKKKDELS 1061
Query: 422 EFLNKSVQKSSGVKST 437
++ KS K S+
Sbjct: 1062 DYAEKSTGKGDSCDSS 1077
Score = 56.2 bits (134), Expect = 8e-08
Identities = 72/357 (20%), Positives = 143/357 (40%), Gaps = 67/357 (18%)
Query: 30 NDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE 89
+DDD+ + ++ E ++ + G D+ E + + +T N +
Sbjct: 1260 DDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPE--------EGKKRTGKQNEENP 1311
Query: 90 GDDEA---AFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENET 146
GD+EA E + EE ++ R + L R K T++D E +T
Sbjct: 1312 GDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKL---TVSDGESG----------EEKKT 1358
Query: 147 TEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGEN 206
KE K + R ++ ++ +Q++ E E ++++ K+ + EN
Sbjct: 1359 KPKEHKEVKGRNRRKVSSEDSEDSDFQESG---VSEEVSESEDEQRPRTRSAKKAELEEN 1415
Query: 207 QGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN 266
Q K K + +R K+QED + K ++E+ +K++E +EE +
Sbjct: 1416 QRSYKQKK-KRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEE--------------- 1459
Query: 267 GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK 326
+ + EN S+ G+ G ++ + ++LR EE E+ K
Sbjct: 1460 -----EEEEEDENDDSKSPGK---------GRKKIRKILKDDKLRTETQNALKEEEERRK 1505
Query: 327 QKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRK--LREEEEKRRLKEEIER 381
+ + E +++RE+ R+V+E E+ + K L E+EE + ++ R
Sbjct: 1506 R--------IAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHR 1554
Score = 43.1 bits (100), Expect = 7e-04
Identities = 79/405 (19%), Positives = 153/405 (37%), Gaps = 95/405 (23%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
++ + D K+T + ++ RE++R K L ++ +++ D S
Sbjct: 1057 KDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQ-------DCSS 1109
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEK 190
S + + N + ++ ++ E R ER + + + DAEE+ +++K+K
Sbjct: 1110 SDTEKYSMKEDGCNSSDKRLKRIELR-ERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKK 1168
Query: 191 EEEEEEKPK-----------------------------------RGSIGENQGEEKGTKV 215
++ K K + SIGE +E+ K+
Sbjct: 1169 KQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQ--KI 1226
Query: 216 QAKREKLQEDKPTFKKEEIKDEKIKK-----------DKEPK---------EEVKSFMDR 255
+ E L T + DE + K D +P+ EE+K+ +
Sbjct: 1227 KPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSS 1286
Query: 256 -KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK------RLE 308
+ G ++ + + G+ T K ++ EN PG + + +E E K RL
Sbjct: 1287 DEDGSSDDEPEEGKKRTGK-QNEEN----PGDEEAKNQVNSESDSDSEESKKPRYRHRLL 1341
Query: 309 ELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE-----------RRKVLEEEEQRR 357
+ + ES E +K K K+ + K E+ +V E E+++R
Sbjct: 1342 RHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQR 1401
Query: 358 KQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 402
+ + +K EE +R K++ +RRR K+ ED S++K
Sbjct: 1402 PRTRSAKKAELEENQRSYKQKKKRRRI-------KVQEDSSSENK 1439
Score = 41.2 bits (95), Expect = 0.003
Identities = 24/113 (21%), Positives = 58/113 (51%), Gaps = 5/113 (4%)
Query: 5 ERRRELR-RQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E +R + ++KR ++++ + + +++ +EEE +E +E ++++E +
Sbjct: 1414 ENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSP 1473
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALE 116
+ + + D++ +T T N E ++ +R+A RE R+K L+E +E
Sbjct: 1474 GKGRKKIRKILKDDKLRTETQNALKEEEERR---KRIAEREREREK-LREVIE 1522
Score = 35.4 bits (80), Expect = 0.14
Identities = 80/430 (18%), Positives = 165/430 (38%), Gaps = 49/430 (11%)
Query: 19 RLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEE 78
RL ++ A D ++ + +E+ + + R + +E+S T + Q+ + D
Sbjct: 907 RLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCK-KVQDGLSDIA 965
Query: 79 AKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSR--- 135
K + E ++ + E+++ ++ + + ++ + +D + LP R
Sbjct: 966 EKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEI 1025
Query: 136 --------RMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKED 187
+++N T + E K+ + ++ +++ E+ ++ KS K D D+ E+KK
Sbjct: 1026 CHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDEL--SDYAEKSTGKGDSCDSSEDKKSK 1083
Query: 188 KEKEEEEEEK--------PKRGSIGENQGEEKGTK--------VQAKREKLQEDKPTFKK 231
E+++ KR + E+ K + KR +L+E + K
Sbjct: 1084 NGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSK 1143
Query: 232 EEIK---------DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFS 282
K D + + K++ ++ +K + K +N + K K + T S
Sbjct: 1144 RNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSS 1203
Query: 283 RPGGRASVDTKE-AEGAPQVEAGKRLEE---LRRRRGETESEEFEKLKQKQQEAALELEE 338
D EG+ + K + E L G +S E L K ++ ++
Sbjct: 1204 SSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEAL-SKSVPVTVDDDD 1262
Query: 339 LKKKREER--RKVLEEEEQRRKQEEADRKLREEEE---KRRLKEEIERRRAEAAEKRQKM 393
E R +K+L EE + + D +E E KR K+ E E A+ +
Sbjct: 1263 DDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNS 1322
Query: 394 PEDGLSDDKK 403
D S++ K
Sbjct: 1323 ESDSDSEESK 1332
Score = 35.0 bits (79), Expect = 0.18
Identities = 30/112 (26%), Positives = 45/112 (40%), Gaps = 14/112 (12%)
Query: 140 DTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE-ENKKEDKEKEEEEEEKP 198
+ ++ E T EKS+S + VTK + +D + + E ED E E +
Sbjct: 58 ENSKEEGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDIT 117
Query: 199 KRGSIGENQGEEKGTKVQAKREKLQEDKPTFK------KEEIKDEKIKKDKE 244
Q KGT + L EDK FK + ++K E +KK E
Sbjct: 118 M-------QSLPKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGE 162
Score = 33.5 bits (75), Expect = 0.53
Identities = 75/368 (20%), Positives = 142/368 (38%), Gaps = 46/368 (12%)
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQK-RLQEALER 117
L Q TD E+++ + +A + V D + A LA E+ + R +A+ +
Sbjct: 374 LKQATDNSEISSATKLRQLKAFKS-----VLADIKKA---HLALEEDLNSEFRAMDAVNK 425
Query: 118 QKEF-DPTITDASLSLPSRRMQNDTA-ENETTEKEEKSESRQERYEIEETETVTKSYQKN 175
+K + + DA +R+ + A E + K E SR++ + V Q+
Sbjct: 426 EKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRT 485
Query: 176 DWRDAEENKKEDKEKEEEEEEKPKR-----------GSIGENQGEEKGTKVQAKRE-KLQ 223
+ E+KK D+++E + E S+ E+ E T ++ + Q
Sbjct: 486 NKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQ 545
Query: 224 EDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKL--KHTENTF 281
D + ++E++ +K + K D + G +KS+ +T +L K T +
Sbjct: 546 GDGSSGTEQEVESSSVKLNISSK-------DNRGG---IKSKTTAKVTKELYVKLTPVSL 595
Query: 282 SR---PGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEE 338
S G ++ +G +LE+ + +++E + E +L LEE
Sbjct: 596 SNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHL-----VENEVSLLLEE 650
Query: 339 LKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGL 398
+R R K RR E +EE +E ++ +K ++ D
Sbjct: 651 SDLRRSPRVKT---TPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSA 707
Query: 399 SDDKKPFK 406
D+ KP K
Sbjct: 708 IDNPKPNK 715
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 85.1 bits (209), Expect = 2e-16
Identities = 112/536 (20%), Positives = 230/536 (42%), Gaps = 74/536 (13%)
Query: 7 RRELRRQKREEMRLEAERIAYQRN------DDDEEEAARERRRR--ARQERLRQKQ-EEE 57
R +L+ + +RL+AE +A Q++ + +EEA RE RRR A ++ +RQ++ E+
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 58 SLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLER-LARREERRQKRLQEALE 116
L + E AQ + E+ +G+ + LE LAR + Q+ E
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
+ E + + L S+ + + + + + +++ E+ R+ E +
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1812
Query: 177 WRDAEENKKEDKEKEEEEEEK---PKRGSIGE-----NQGEEKGTKVQAKREKLQE--DK 226
+ + +ED ++ E E+ K +IGE + E + +A+ E+L+ +
Sbjct: 1813 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Query: 227 PTFKKEEIKDEKIKKDKEPKEEVK-------SFMDRKKGFTEVKSQNGEFMTHKLKHTEN 279
F++ ++++ + + +E + S ++R+KG E + + ++ +
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1932
Query: 280 TFSRPG-GRASV------------DTKEAEGAPQVEAGKR----LEELRRRRGETE---- 318
+F + G+A + DT ++ ++EA ++ EE RRRR E
Sbjct: 1933 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1992
Query: 319 SEEFEKLKQKQQEAALE-LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKE 377
S E+ +Q++AALE +E LK K EE R++ E EQ ++ +L +E ++RL+
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ---LQLAQEAAQKRLQA 2049
Query: 378 EIERRRAEAAEKRQKMPE---------DGLSDDKKPFKCFTPKGSSLKIE---------- 418
E + +K Q++ + D L + + + + +++
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109
Query: 419 --ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 472
E AE L +S ++ + ++ QAA K+ EQ + + A + A+D
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Score = 81.3 bits (199), Expect = 2e-15
Identities = 105/450 (23%), Positives = 190/450 (42%), Gaps = 72/450 (16%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1744
Query: 46 RQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1745 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 95 AFLERLARREERRQKRLQEALERQK---------------EFDPTITDASLSLPSRRMQN 139
A L LA +R+++ +E RQ+ E T+A ++L + +N
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 140 D----TAENETTEKEE-KSESRQERYEIEETETVTKSYQKNDWRD----AEENKKEDKEK 190
+ AE+E ++ + ++ Q + +IEE + ++ E+ ++ ++
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 191 EEE--------EEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKD 242
EEE E+ + + G + R K Q + ++ ++ E+ ++
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983
Query: 243 KEPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV 301
+E +E V KS ++ + K+ E +LK R RA ++ Q
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEE--VERLKAKVEEARRLRERAEQESARQLQLAQE 2041
Query: 302 EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 361
A KRL+ + ++ ++L+Q Q+ L++L+ + E R+ EE E+ R Q E
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2101
Query: 362 ADRKLREEEEKRRLKEEIERRRAEAAEKRQ 391
RE + RR EE ER + A E+ Q
Sbjct: 2102 -----REAAQSRRQVEEAERLKQSAEEQAQ 2126
Score = 78.2 bits (191), Expect = 2e-14
Identities = 91/412 (22%), Positives = 176/412 (42%), Gaps = 43/412 (10%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1783 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Query: 170 KSYQKNDWRDAEENK--KEDKEKEEEEEEKPKRGSIGENQG--EEKGTKVQAKREKLQED 225
+S ++ + A + + E++ + E EE+ ++ E + + K + +R K + +
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019
Query: 226 KPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRP 284
+ +E + E ++ + +E K +K Q + + L+ ++ +
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 285 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 344
G A + AE A + E + RR + EE E+LKQ +E A + + E
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAE 2136
Query: 345 ERRKVLEEEEQRRKQEEADRKLR-------EEEEKRRLKEEIERRRAEAAEK 389
+ RK E+E RR Q E LR E E+ ++ E+ R++A+ ++
Sbjct: 2137 KLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187
Score = 77.0 bits (188), Expect = 4e-14
Identities = 92/408 (22%), Positives = 172/408 (42%), Gaps = 33/408 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARE----RRRRARQERLRQKQEE-ESLG 60
R E QKR+ EAER+ Q D+ + + E R +A E R+KQ ++L
Sbjct: 1481 RAEEAEAQKRQAQE-EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
++ Q E + E + +E +A E ++R +K Q Q+E
Sbjct: 1540 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ A L + R AE E +E +E ER++++ E + Q +
Sbjct: 1600 H---VAVAQLREEAERRAQQQAEAERAREE--AERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 181 EE--NKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE- 237
+ + +K+KEE E E +RG E ++ Q ++ Q + T ++ ++
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 238 --KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEA 295
+++ + E E+ + ++ + + + T K + E ++ RA ++ A
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQ---REAAAATQKRQELEAELAKV--RAEMEVLLA 1769
Query: 296 EGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQ 355
A E + E ++R E E+ F +L ++ EE K++R+ L EE+
Sbjct: 1770 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-----LAEEDA 1824
Query: 356 RRKQEEADRKLREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 396
R++ EA+R L E+ E RLK E E + + E+ +++ ED
Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Score = 75.1 bits (183), Expect = 2e-13
Identities = 98/421 (23%), Positives = 183/421 (43%), Gaps = 64/421 (15%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ-ERLRQKQEEESLGQVTD 64
R+R+L ++ R ER+ Q++ EEEAAR+R+ + ERL+ K EE +
Sbjct: 1971 RQRQLAAEEERRRREAEERV--QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2028
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ E Q + E A+ +RL E+ +Q ++++E T
Sbjct: 2029 EQESARQLQLAQEAAQ-----------------KRLQAEEKAHAFAVQ---QKEQELQQT 2068
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVTKSYQKNDWRD 179
+ L R + + A E EE + E+ Q R ++EE E + +S ++
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQGEEK-GTKVQAKREKLQEDKPTFKKEEIKDE- 237
A+ +K ++E E+E +R + +K + ++ K ++ +K +++ E
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2188
Query: 238 -KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE-A 295
++ E + K+ +D + +K++ E + + E FS V +E +
Sbjct: 2189 TTLRLQLEETDHQKNLLDEE--LQRLKAEATEAARQRSQVEEELFS-----VRVQMEELS 2241
Query: 296 EGAPQVEAGKRLEELRRRRGETE--SEEFEKLKQKQQEAA--------------LELEEL 339
+ ++EA R LR + EE EK+KQ +EAA L E+L
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301
Query: 340 KKKREERRKVLEE-----EEQRRKQEEAD----RKLREEEEKRRLKEEIERRRAEAAEKR 390
++R K+L+E +E R + EA+ +K +E+ RRL+E+ E+ + AE+
Sbjct: 2302 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2361
Query: 391 Q 391
Q
Sbjct: 2362 Q 2362
Score = 75.1 bits (183), Expect = 2e-13
Identities = 86/421 (20%), Positives = 181/421 (42%), Gaps = 34/421 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2237
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESR 156
+ +Q+ L E + ++K E +A L + + + A +KE+ ++
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 157 QERYE-IEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKV 215
E + + T + Q +AE K E + + Q EE G K+
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 216 QAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 275
QE + EI+ ++ D E E + ++R+K + +++ + + +++
Sbjct: 2418 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2477
Query: 276 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 335
+ +A + +E ++ + +E+ + + + +E K +Q ++E +
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2537
Query: 336 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMP 394
++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++
Sbjct: 2538 QQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 395 E 395
E
Sbjct: 2596 E 2596
Score = 69.7 bits (169), Expect = 7e-12
Identities = 109/499 (21%), Positives = 207/499 (41%), Gaps = 136/499 (27%)
Query: 13 QKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQN 72
++ EE R++AER EAA+ RR+ ERL+Q EE++ + Q
Sbjct: 2091 EEAEEARVQAER-----------EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 73 SVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITDASLS 131
++EA + + + A ++ A E + K+ E RQK + + +T L
Sbjct: 2140 KEAEQEAAR-----RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2194
Query: 132 LPSRRMQNDTAENETTE-KEEKSESRQERYEIEET--------ETVTKSYQK-------- 174
L Q + + E K E +E+ ++R ++EE E ++K +
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Query: 175 ------NDWRDAEENKKEDKEKEEE------------------EEEKPKRGSIGENQGEE 210
N R +E ++ K+ EE EE+ ++ ++ E +E
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2314
Query: 211 K------GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFT--- 260
K T+++A+ E LQ+ K E+ E+ ++ +E KE++ + + +GF
Sbjct: 2315 KMQAVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2368
Query: 261 EVKSQNGEFMT---HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE--------- 308
E + Q M+ +LK SR RA D + + E G++L
Sbjct: 2369 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEK 2427
Query: 309 -------ELRRRRGETESE-----------EFEKLKQKQQEAALELEELKKKREE----- 345
E++R++ + ++E E EKL+Q+ + L+ EE++ ++E
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487
Query: 346 -----------------RRKVLEEEEQRRKQEEAD-----RKLREEEEKRRLKEEIERRR 383
R + +E+E+ + +Q D ++LREE+++++ + E ER+R
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2547
Query: 384 ----AEAAEKRQKMPEDGL 398
E A +RQ E+G+
Sbjct: 2548 LVASMEEARRRQHEAEEGV 2566
Score = 65.9 bits (159), Expect = 1e-10
Identities = 98/420 (23%), Positives = 182/420 (43%), Gaps = 33/420 (7%)
Query: 5 ERRRELRRQKREEMR-LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQV 62
E RR R ++E R L+ + A Q+ EE+A ++ QE + Q+E+S L Q+
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALE 116
+ E + + EEA+ + + ERL + EE+ Q R Q E L
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
++ E + + R+ Q AE E +K + RQ+ +E T+ ++ D
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKE---- 232
+ +++ + K E E +R +Q EE+ V+ + E+L + K + E
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQR-----SQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Query: 233 --EIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 290
KD + +E E++K + + + + E ++ A
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR----QLAEEDLAQQRALAEK 2310
Query: 291 DTKEAEGAPQVEAGKRLE-ELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 349
KE A Q + E EL +++ E E+ +L++ +++ A ++L ++ + ++
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA---QQLAEETQGFQRT 2367
Query: 350 LEEEEQRRKQ--EEADR-KLREEEEKR---RLKEEIERRRAEAAEKRQKMPEDGLSDDKK 403
LE E QR+ + EA+R KLR E R R +E+ +R R +A E +K+ L+ +K
Sbjct: 2368 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427
Score = 64.7 bits (156), Expect = 2e-10
Identities = 103/481 (21%), Positives = 196/481 (40%), Gaps = 80/481 (16%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEA-ARERRRRARQ-------------ERLRQKQ----E 55
++ E+ ++ Y R D A ++ RRR Q E+LRQ+Q E
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Query: 56 EESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ 112
E G+ ++ + A+ N++ D E + T Q+E A + + + + +Q
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVASPAKKPKVQSGSESVIQ 1314
Query: 113 EALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET 167
E ++ + + T S +S RRM+ E E +++++E R+ E+E
Sbjct: 1315 EYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALE 1370
Query: 168 VTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKP 227
+ + + + ++E KE ++ +E+ R EE Q ++ +QE+
Sbjct: 1371 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR-------EEAAVDAQQQKRSIQEELQ 1423
Query: 228 TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGR 287
++ + E K ++ + +S + ++ V+ Q L+ TE R G
Sbjct: 1424 QLRQSS-EAEIQAKARQAEAAERSRLRIEEEIRVVRLQ--------LEATER--QRGGAE 1472
Query: 288 ASVDTKEAEGAPQVEAGKRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE 345
+ A A + EA KR EE R R + + E K + + + A+ E + RE+
Sbjct: 1473 GELQALRAR-AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1531
Query: 346 RRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF 405
+R + EE R + EEA+R+LR+ E +R + ++ A E Q+ E L
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVERARQVQV------ALETAQRSAEAELQ------ 1579
Query: 406 KCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSA 463
+RA F K+ Q ++ H A + + + R +Q A + A
Sbjct: 1580 ------------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627
Query: 464 K 464
+
Sbjct: 1628 E 1628
Score = 62.0 bits (149), Expect = 1e-09
Identities = 90/402 (22%), Positives = 161/402 (40%), Gaps = 62/402 (15%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
E R+ EE RL ++ A +R E EAA E++R+ + + K + E + + +
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER--EAKELQQR 1396
Query: 69 NAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITD 127
+ V EEA + +E L + + E + + R EA ER + + I
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 128 ASLSLPSRRMQNDTAENETTEKEEKSESR--QERYEIEETETVTKSYQKNDWRDAEENKK 185
L L + Q AE E ++E Q+R EE E + + Q
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD----------- 1505
Query: 186 EDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKRE-KLQEDKPTFKKEEIKDEKIKKDKE 244
E + K + E E R EK +QA E +LQ ++ + + + E+ ++ +
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1565
Query: 245 PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE-- 302
E T +S E + + E T + E + Q E
Sbjct: 1566 ALE------------TAQRSAEAELQSKRASFAEKT------------AQLERSLQEEHV 1601
Query: 303 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE------------RRKVL 350
A +L E RR + ++E ++ ++EA ELE + K E ++K L
Sbjct: 1602 AVAQLREEAERRAQQQAEA----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1657
Query: 351 EEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 392
+ E +++EEA+R+ R + + +E+ R+R A ++ +K
Sbjct: 1658 AQAEAEKQKEEAEREAR---RRGKAEEQAVRQRELAEQELEK 1696
Score = 62.0 bits (149), Expect = 1e-09
Identities = 81/393 (20%), Positives = 173/393 (44%), Gaps = 37/393 (9%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR----ARQERLRQKQEEES 58
D + + +++ E+M+ AE A R +EAAR R+ A+Q L +K +E
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2315
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
+ V + + A+ + ++ + + +D+ ++LA + Q+ L+ ERQ
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA--ERQ 2373
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
++ + + L L M A E + + ++ + ++ TE T+ +
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE------K 2427
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQ-EDKPTFKKEEIKDE 237
E + ++ + + + R +I E + E++ + +AK +L+ E+ T ++E++ E
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487
Query: 238 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEG 297
+ E S + R++ + K++ + ++ + R + E E
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL--REEQQRQQQQMEQER 2545
Query: 298 APQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR---KVLEEEE 354
V + +EE RRR+ E E E +++KQ EEL++ ++RR ++L EE
Sbjct: 2546 QRLVAS---MEEARRRQHEAE----EGVRRKQ-------EELQQLEQQRRQQEELLAEEN 2591
Query: 355 QRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 387
QR +++ +L EE+ + L E ++ A
Sbjct: 2592 QRLREQ---LQLLEEQHRAALAHSEEVTASQVA 2621
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 85.1 bits (209), Expect = 2e-16
Identities = 112/536 (20%), Positives = 230/536 (42%), Gaps = 74/536 (13%)
Query: 7 RRELRRQKREEMRLEAERIAYQRN------DDDEEEAARERRRR--ARQERLRQKQ-EEE 57
R +L+ + +RL+AE +A Q++ + +EEA RE RRR A ++ +RQ++ E+
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696
Query: 58 SLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLER-LARREERRQKRLQEALE 116
L + E AQ + E+ +G+ + LE LAR + Q+ E
Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1756
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
+ E + + L S+ + + + + + +++ E+ R+ E +
Sbjct: 1757 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1816
Query: 177 WRDAEENKKEDKEKEEEEEEK---PKRGSIGE-----NQGEEKGTKVQAKREKLQE--DK 226
+ + +ED ++ E E+ K +IGE + E + +A+ E+L+ +
Sbjct: 1817 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1876
Query: 227 PTFKKEEIKDEKIKKDKEPKEEVK-------SFMDRKKGFTEVKSQNGEFMTHKLKHTEN 279
F++ ++++ + + +E + S ++R+KG E + + ++ +
Sbjct: 1877 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1936
Query: 280 TFSRPG-GRASV------------DTKEAEGAPQVEAGKR----LEELRRRRGETE---- 318
+F + G+A + DT ++ ++EA ++ EE RRRR E
Sbjct: 1937 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1996
Query: 319 SEEFEKLKQKQQEAALE-LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKE 377
S E+ +Q++AALE +E LK K EE R++ E EQ ++ +L +E ++RL+
Sbjct: 1997 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ---LQLAQEAAQKRLQA 2053
Query: 378 EIERRRAEAAEKRQKMPE---------DGLSDDKKPFKCFTPKGSSLKIE---------- 418
E + +K Q++ + D L + + + + +++
Sbjct: 2054 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2113
Query: 419 --ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 472
E AE L +S ++ + ++ QAA K+ EQ + + A + A+D
Sbjct: 2114 QVEEAERLKQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2168
Score = 81.3 bits (199), Expect = 2e-15
Identities = 105/450 (23%), Positives = 190/450 (42%), Gaps = 72/450 (16%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1689 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1748
Query: 46 RQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1749 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807
Query: 95 AFLERLARREERRQKRLQEALERQK---------------EFDPTITDASLSLPSRRMQN 139
A L LA +R+++ +E RQ+ E T+A ++L + +N
Sbjct: 1808 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1867
Query: 140 D----TAENETTEKEE-KSESRQERYEIEETETVTKSYQKNDWRD----AEENKKEDKEK 190
+ AE+E ++ + ++ Q + +IEE + ++ E+ ++ ++
Sbjct: 1868 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1927
Query: 191 EEE--------EEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKD 242
EEE E+ + + G + R K Q + ++ ++ E+ ++
Sbjct: 1928 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1987
Query: 243 KEPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV 301
+E +E V KS ++ + K+ E +LK R RA ++ Q
Sbjct: 1988 REAEERVQKSLAAEEEAARQRKAALEE--VERLKAKVEEARRLRERAEQESARQLQLAQE 2045
Query: 302 EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 361
A KRL+ + ++ ++L+Q Q+ L++L+ + E R+ EE E+ R Q E
Sbjct: 2046 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2105
Query: 362 ADRKLREEEEKRRLKEEIERRRAEAAEKRQ 391
RE + RR EE ER + A E+ Q
Sbjct: 2106 -----REAAQSRRQVEEAERLKQSAEEQAQ 2130
Score = 78.2 bits (191), Expect = 2e-14
Identities = 91/412 (22%), Positives = 176/412 (42%), Gaps = 43/412 (10%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1787 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1843
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1844 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1903
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1963
Query: 170 KSYQKNDWRDAEENK--KEDKEKEEEEEEKPKRGSIGENQG--EEKGTKVQAKREKLQED 225
+S ++ + A + + E++ + E EE+ ++ E + + K + +R K + +
Sbjct: 1964 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2023
Query: 226 KPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRP 284
+ +E + E ++ + +E K +K Q + + L+ ++ +
Sbjct: 2024 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2083
Query: 285 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 344
G A + AE A + E + RR + EE E+LKQ +E A + + E
Sbjct: 2084 RGEAEAARRAAEEAEEARVQAEREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAE 2140
Query: 345 ERRKVLEEEEQRRKQEEADRKLR-------EEEEKRRLKEEIERRRAEAAEK 389
+ RK E+E RR Q E LR E E+ ++ E+ R++A+ ++
Sbjct: 2141 KLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2191
Score = 77.0 bits (188), Expect = 4e-14
Identities = 92/408 (22%), Positives = 172/408 (42%), Gaps = 33/408 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARE----RRRRARQERLRQKQEE-ESLG 60
R E QKR+ EAER+ Q D+ + + E R +A E R+KQ ++L
Sbjct: 1485 RAEEAEAQKRQAQE-EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1543
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
++ Q E + E + +E +A E ++R +K Q Q+E
Sbjct: 1544 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1603
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ A L + R AE E +E +E ER++++ E + Q +
Sbjct: 1604 H---VAVAQLREEAERRAQQQAEAERAREE--AERELERWQLKANEALRLRLQAEEVAQQ 1658
Query: 181 EE--NKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE- 237
+ + +K+KEE E E +RG E ++ Q ++ Q + T ++ ++
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1718
Query: 238 --KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEA 295
+++ + E E+ + ++ + + + T K + E ++ RA ++ A
Sbjct: 1719 LIRLRAETEQGEQQRQLLEEELARLQ---REAAAATQKRQELEAELAKV--RAEMEVLLA 1773
Query: 296 EGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQ 355
A E + E ++R E E+ F +L ++ EE K++R+ L EE+
Sbjct: 1774 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-----LAEEDA 1828
Query: 356 RRKQEEADRKLREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 396
R++ EA+R L E+ E RLK E E + + E+ +++ ED
Sbjct: 1829 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1876
Score = 75.1 bits (183), Expect = 2e-13
Identities = 98/421 (23%), Positives = 183/421 (43%), Gaps = 64/421 (15%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ-ERLRQKQEEESLGQVTD 64
R+R+L ++ R ER+ Q++ EEEAAR+R+ + ERL+ K EE +
Sbjct: 1975 RQRQLAAEEERRRREAEERV--QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2032
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ E Q + E A+ +RL E+ +Q ++++E T
Sbjct: 2033 EQESARQLQLAQEAAQ-----------------KRLQAEEKAHAFAVQ---QKEQELQQT 2072
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVTKSYQKNDWRD 179
+ L R + + A E EE + E+ Q R ++EE E + +S ++
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2132
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQGEEK-GTKVQAKREKLQEDKPTFKKEEIKDE- 237
A+ +K ++E E+E +R + +K + ++ K ++ +K +++ E
Sbjct: 2133 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2192
Query: 238 -KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE-A 295
++ E + K+ +D + +K++ E + + E FS V +E +
Sbjct: 2193 TTLRLQLEETDHQKNLLDEE--LQRLKAEATEAARQRSQVEEELFS-----VRVQMEELS 2245
Query: 296 EGAPQVEAGKRLEELRRRRGETE--SEEFEKLKQKQQEAA--------------LELEEL 339
+ ++EA R LR + EE EK+KQ +EAA L E+L
Sbjct: 2246 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2305
Query: 340 KKKREERRKVLEE-----EEQRRKQEEAD----RKLREEEEKRRLKEEIERRRAEAAEKR 390
++R K+L+E +E R + EA+ +K +E+ RRL+E+ E+ + AE+
Sbjct: 2306 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2365
Query: 391 Q 391
Q
Sbjct: 2366 Q 2366
Score = 75.1 bits (183), Expect = 2e-13
Identities = 86/421 (20%), Positives = 181/421 (42%), Gaps = 34/421 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2241
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2242 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2301
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESR 156
+ +Q+ L E + ++K E +A L + + + A +KE+ ++
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2361
Query: 157 QERYE-IEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKV 215
E + + T + Q +AE K E + + Q EE G K+
Sbjct: 2362 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421
Query: 216 QAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 275
QE + EI+ ++ D E E + ++R+K + +++ + + +++
Sbjct: 2422 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2481
Query: 276 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 335
+ +A + +E ++ + +E+ + + + +E K +Q ++E +
Sbjct: 2482 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2541
Query: 336 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMP 394
++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++
Sbjct: 2542 QQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2599
Query: 395 E 395
E
Sbjct: 2600 E 2600
Score = 69.7 bits (169), Expect = 7e-12
Identities = 109/499 (21%), Positives = 207/499 (41%), Gaps = 136/499 (27%)
Query: 13 QKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQN 72
++ EE R++AER EAA+ RR+ ERL+Q EE++ + Q
Sbjct: 2095 EEAEEARVQAER-----------EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2143
Query: 73 SVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITDASLS 131
++EA + + + A ++ A E + K+ E RQK + + +T L
Sbjct: 2144 KEAEQEAAR-----RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2198
Query: 132 LPSRRMQNDTAENETTE-KEEKSESRQERYEIEET--------ETVTKSYQK-------- 174
L Q + + E K E +E+ ++R ++EE E ++K +
Sbjct: 2199 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2258
Query: 175 ------NDWRDAEENKKEDKEKEEE------------------EEEKPKRGSIGENQGEE 210
N R +E ++ K+ EE EE+ ++ ++ E +E
Sbjct: 2259 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2318
Query: 211 K------GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFT--- 260
K T+++A+ E LQ+ K E+ E+ ++ +E KE++ + + +GF
Sbjct: 2319 KMQAVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2372
Query: 261 EVKSQNGEFMT---HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE--------- 308
E + Q M+ +LK SR RA D + + E G++L
Sbjct: 2373 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEK 2431
Query: 309 -------ELRRRRGETESE-----------EFEKLKQKQQEAALELEELKKKREE----- 345
E++R++ + ++E E EKL+Q+ + L+ EE++ ++E
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2491
Query: 346 -----------------RRKVLEEEEQRRKQEEAD-----RKLREEEEKRRLKEEIERRR 383
R + +E+E+ + +Q D ++LREE+++++ + E ER+R
Sbjct: 2492 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2551
Query: 384 ----AEAAEKRQKMPEDGL 398
E A +RQ E+G+
Sbjct: 2552 LVASMEEARRRQHEAEEGV 2570
Score = 65.9 bits (159), Expect = 1e-10
Identities = 98/420 (23%), Positives = 182/420 (43%), Gaps = 33/420 (7%)
Query: 5 ERRRELRRQKREEMR-LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQV 62
E RR R ++E R L+ + A Q+ EE+A ++ QE + Q+E+S L Q+
Sbjct: 2024 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2083
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALE 116
+ E + + EEA+ + + ERL + EE+ Q R Q E L
Sbjct: 2084 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2143
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
++ E + + R+ Q AE E +K + RQ+ +E T+ ++ D
Sbjct: 2144 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2203
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKE---- 232
+ +++ + K E E +R +Q EE+ V+ + E+L + K + E
Sbjct: 2204 HQKNLLDEELQRLKAEATEAARQR-----SQVEEELFSVRVQMEELSKLKARIEAENRAL 2258
Query: 233 --EIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 290
KD + +E E++K + + + + E ++ A
Sbjct: 2259 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR----QLAEEDLAQQRALAEK 2314
Query: 291 DTKEAEGAPQVEAGKRLE-ELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 349
KE A Q + E EL +++ E E+ +L++ +++ A ++L ++ + ++
Sbjct: 2315 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA---QQLAEETQGFQRT 2371
Query: 350 LEEEEQRRKQ--EEADR-KLREEEEKR---RLKEEIERRRAEAAEKRQKMPEDGLSDDKK 403
LE E QR+ + EA+R KLR E R R +E+ +R R +A E +K+ L+ +K
Sbjct: 2372 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2431
Score = 64.7 bits (156), Expect = 2e-10
Identities = 103/481 (21%), Positives = 196/481 (40%), Gaps = 80/481 (16%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEA-ARERRRRARQ-------------ERLRQKQ----E 55
++ E+ ++ Y R D A ++ RRR Q E+LRQ+Q E
Sbjct: 1202 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1261
Query: 56 EESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ 112
E G+ ++ + A+ N++ D E + T Q+E A + + + + +Q
Sbjct: 1262 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVASPAKKPKVQSGSESVIQ 1318
Query: 113 EALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET 167
E ++ + + T S +S RRM+ E E +++++E R+ E+E
Sbjct: 1319 EYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALE 1374
Query: 168 VTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKP 227
+ + + + ++E KE ++ +E+ R EE Q ++ +QE+
Sbjct: 1375 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR-------EEAAVDAQQQKRSIQEELQ 1427
Query: 228 TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGR 287
++ + E K ++ + +S + ++ V+ Q L+ TE R G
Sbjct: 1428 QLRQSS-EAEIQAKARQAEAAERSRLRIEEEIRVVRLQ--------LEATER--QRGGAE 1476
Query: 288 ASVDTKEAEGAPQVEAGKRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE 345
+ A A + EA KR EE R R + + E K + + + A+ E + RE+
Sbjct: 1477 GELQALRAR-AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1535
Query: 346 RRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF 405
+R + EE R + EEA+R+LR+ E +R + ++ A E Q+ E L
Sbjct: 1536 QRALQALEELRLQAEEAERRLRQAEVERARQVQV------ALETAQRSAEAELQ------ 1583
Query: 406 KCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSA 463
+RA F K+ Q ++ H A + + + R +Q A + A
Sbjct: 1584 ------------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1631
Query: 464 K 464
+
Sbjct: 1632 E 1632
Score = 62.0 bits (149), Expect = 1e-09
Identities = 90/402 (22%), Positives = 161/402 (40%), Gaps = 62/402 (15%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
E R+ EE RL ++ A +R E EAA E++R+ + + K + E + + +
Sbjct: 1343 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER--EAKELQQR 1400
Query: 69 NAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITD 127
+ V EEA + +E L + + E + + R EA ER + + I
Sbjct: 1401 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1460
Query: 128 ASLSLPSRRMQNDTAENETTEKEEKSESR--QERYEIEETETVTKSYQKNDWRDAEENKK 185
L L + Q AE E ++E Q+R EE E + + Q
Sbjct: 1461 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD----------- 1509
Query: 186 EDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKRE-KLQEDKPTFKKEEIKDEKIKKDKE 244
E + K + E E R EK +QA E +LQ ++ + + + E+ ++ +
Sbjct: 1510 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1569
Query: 245 PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE-- 302
E T +S E + + E T + E + Q E
Sbjct: 1570 ALE------------TAQRSAEAELQSKRASFAEKT------------AQLERSLQEEHV 1605
Query: 303 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE------------RRKVL 350
A +L E RR + ++E ++ ++EA ELE + K E ++K L
Sbjct: 1606 AVAQLREEAERRAQQQAEA----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1661
Query: 351 EEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 392
+ E +++EEA+R+ R + + +E+ R+R A ++ +K
Sbjct: 1662 AQAEAEKQKEEAEREAR---RRGKAEEQAVRQRELAEQELEK 1700
Score = 62.0 bits (149), Expect = 1e-09
Identities = 81/393 (20%), Positives = 173/393 (44%), Gaps = 37/393 (9%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR----ARQERLRQKQEEES 58
D + + +++ E+M+ AE A R +EAAR R+ A+Q L +K +E
Sbjct: 2262 DKDNTQRFLQEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2319
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
+ V + + A+ + ++ + + +D+ ++LA + Q+ L+ ERQ
Sbjct: 2320 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA--ERQ 2377
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
++ + + L L M A E + + ++ + ++ TE T+ +
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE------K 2431
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQ-EDKPTFKKEEIKDE 237
E + ++ + + + R +I E + E++ + +AK +L+ E+ T ++E++ E
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2491
Query: 238 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEG 297
+ E S + R++ + K++ + ++ + R + E E
Sbjct: 2492 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL--REEQQRQQQQMEQER 2549
Query: 298 APQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR---KVLEEEE 354
V + +EE RRR+ E E E +++KQ EEL++ ++RR ++L EE
Sbjct: 2550 QRLVAS---MEEARRRQHEAE----EGVRRKQ-------EELQQLEQQRRQQEELLAEEN 2595
Query: 355 QRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 387
QR +++ +L EE+ + L E ++ A
Sbjct: 2596 QRLREQ---LQLLEEQHRAALAHSEEVTASQVA 2625
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 85.1 bits (209), Expect = 2e-16
Identities = 112/536 (20%), Positives = 230/536 (42%), Gaps = 74/536 (13%)
Query: 7 RRELRRQKREEMRLEAERIAYQRN------DDDEEEAARERRRR--ARQERLRQKQ-EEE 57
R +L+ + +RL+AE +A Q++ + +EEA RE RRR A ++ +RQ++ E+
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 58 SLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLER-LARREERRQKRLQEALE 116
L + E AQ + E+ +G+ + LE LAR + Q+ E
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
+ E + + L S+ + + + + + +++ E+ R+ E +
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1812
Query: 177 WRDAEENKKEDKEKEEEEEEK---PKRGSIGE-----NQGEEKGTKVQAKREKLQE--DK 226
+ + +ED ++ E E+ K +IGE + E + +A+ E+L+ +
Sbjct: 1813 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Query: 227 PTFKKEEIKDEKIKKDKEPKEEVK-------SFMDRKKGFTEVKSQNGEFMTHKLKHTEN 279
F++ ++++ + + +E + S ++R+KG E + + ++ +
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1932
Query: 280 TFSRPG-GRASV------------DTKEAEGAPQVEAGKR----LEELRRRRGETE---- 318
+F + G+A + DT ++ ++EA ++ EE RRRR E
Sbjct: 1933 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1992
Query: 319 SEEFEKLKQKQQEAALE-LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKE 377
S E+ +Q++AALE +E LK K EE R++ E EQ ++ +L +E ++RL+
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ---LQLAQEAAQKRLQA 2049
Query: 378 EIERRRAEAAEKRQKMPE---------DGLSDDKKPFKCFTPKGSSLKIE---------- 418
E + +K Q++ + D L + + + + +++
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109
Query: 419 --ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 472
E AE L +S ++ + ++ QAA K+ EQ + + A + A+D
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Score = 81.3 bits (199), Expect = 2e-15
Identities = 105/450 (23%), Positives = 190/450 (42%), Gaps = 72/450 (16%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1744
Query: 46 RQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1745 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 95 AFLERLARREERRQKRLQEALERQK---------------EFDPTITDASLSLPSRRMQN 139
A L LA +R+++ +E RQ+ E T+A ++L + +N
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 140 D----TAENETTEKEE-KSESRQERYEIEETETVTKSYQKNDWRD----AEENKKEDKEK 190
+ AE+E ++ + ++ Q + +IEE + ++ E+ ++ ++
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 191 EEE--------EEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKD 242
EEE E+ + + G + R K Q + ++ ++ E+ ++
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983
Query: 243 KEPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV 301
+E +E V KS ++ + K+ E +LK R RA ++ Q
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEE--VERLKAKVEEARRLRERAEQESARQLQLAQE 2041
Query: 302 EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 361
A KRL+ + ++ ++L+Q Q+ L++L+ + E R+ EE E+ R Q E
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2101
Query: 362 ADRKLREEEEKRRLKEEIERRRAEAAEKRQ 391
RE + RR EE ER + A E+ Q
Sbjct: 2102 -----REAAQSRRQVEEAERLKQSAEEQAQ 2126
Score = 78.2 bits (191), Expect = 2e-14
Identities = 91/412 (22%), Positives = 176/412 (42%), Gaps = 43/412 (10%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1783 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Query: 170 KSYQKNDWRDAEENK--KEDKEKEEEEEEKPKRGSIGENQG--EEKGTKVQAKREKLQED 225
+S ++ + A + + E++ + E EE+ ++ E + + K + +R K + +
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019
Query: 226 KPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRP 284
+ +E + E ++ + +E K +K Q + + L+ ++ +
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 285 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 344
G A + AE A + E + RR + EE E+LKQ +E A + + E
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAE 2136
Query: 345 ERRKVLEEEEQRRKQEEADRKLR-------EEEEKRRLKEEIERRRAEAAEK 389
+ RK E+E RR Q E LR E E+ ++ E+ R++A+ ++
Sbjct: 2137 KLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187
Score = 77.0 bits (188), Expect = 4e-14
Identities = 92/408 (22%), Positives = 172/408 (42%), Gaps = 33/408 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARE----RRRRARQERLRQKQEE-ESLG 60
R E QKR+ EAER+ Q D+ + + E R +A E R+KQ ++L
Sbjct: 1481 RAEEAEAQKRQAQE-EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
++ Q E + E + +E +A E ++R +K Q Q+E
Sbjct: 1540 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ A L + R AE E +E +E ER++++ E + Q +
Sbjct: 1600 H---VAVAQLREEAERRAQQQAEAERAREE--AERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 181 EE--NKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE- 237
+ + +K+KEE E E +RG E ++ Q ++ Q + T ++ ++
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 238 --KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEA 295
+++ + E E+ + ++ + + + T K + E ++ RA ++ A
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQ---REAAAATQKRQELEAELAKV--RAEMEVLLA 1769
Query: 296 EGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQ 355
A E + E ++R E E+ F +L ++ EE K++R+ L EE+
Sbjct: 1770 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-----LAEEDA 1824
Query: 356 RRKQEEADRKLREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 396
R++ EA+R L E+ E RLK E E + + E+ +++ ED
Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Score = 75.1 bits (183), Expect = 2e-13
Identities = 98/421 (23%), Positives = 183/421 (43%), Gaps = 64/421 (15%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ-ERLRQKQEEESLGQVTD 64
R+R+L ++ R ER+ Q++ EEEAAR+R+ + ERL+ K EE +
Sbjct: 1971 RQRQLAAEEERRRREAEERV--QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2028
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ E Q + E A+ +RL E+ +Q ++++E T
Sbjct: 2029 EQESARQLQLAQEAAQ-----------------KRLQAEEKAHAFAVQ---QKEQELQQT 2068
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVTKSYQKNDWRD 179
+ L R + + A E EE + E+ Q R ++EE E + +S ++
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQGEEK-GTKVQAKREKLQEDKPTFKKEEIKDE- 237
A+ +K ++E E+E +R + +K + ++ K ++ +K +++ E
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2188
Query: 238 -KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE-A 295
++ E + K+ +D + +K++ E + + E FS V +E +
Sbjct: 2189 TTLRLQLEETDHQKNLLDEE--LQRLKAEATEAARQRSQVEEELFS-----VRVQMEELS 2241
Query: 296 EGAPQVEAGKRLEELRRRRGETE--SEEFEKLKQKQQEAA--------------LELEEL 339
+ ++EA R LR + EE EK+KQ +EAA L E+L
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301
Query: 340 KKKREERRKVLEE-----EEQRRKQEEAD----RKLREEEEKRRLKEEIERRRAEAAEKR 390
++R K+L+E +E R + EA+ +K +E+ RRL+E+ E+ + AE+
Sbjct: 2302 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2361
Query: 391 Q 391
Q
Sbjct: 2362 Q 2362
Score = 75.1 bits (183), Expect = 2e-13
Identities = 86/421 (20%), Positives = 181/421 (42%), Gaps = 34/421 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2237
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESR 156
+ +Q+ L E + ++K E +A L + + + A +KE+ ++
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 157 QERYE-IEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKV 215
E + + T + Q +AE K E + + Q EE G K+
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 216 QAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 275
QE + EI+ ++ D E E + ++R+K + +++ + + +++
Sbjct: 2418 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2477
Query: 276 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 335
+ +A + +E ++ + +E+ + + + +E K +Q ++E +
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2537
Query: 336 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMP 394
++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++
Sbjct: 2538 QQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 395 E 395
E
Sbjct: 2596 E 2596
Score = 69.7 bits (169), Expect = 7e-12
Identities = 109/499 (21%), Positives = 207/499 (41%), Gaps = 136/499 (27%)
Query: 13 QKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQN 72
++ EE R++AER EAA+ RR+ ERL+Q EE++ + Q
Sbjct: 2091 EEAEEARVQAER-----------EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 73 SVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITDASLS 131
++EA + + + A ++ A E + K+ E RQK + + +T L
Sbjct: 2140 KEAEQEAAR-----RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2194
Query: 132 LPSRRMQNDTAENETTE-KEEKSESRQERYEIEET--------ETVTKSYQK-------- 174
L Q + + E K E +E+ ++R ++EE E ++K +
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Query: 175 ------NDWRDAEENKKEDKEKEEE------------------EEEKPKRGSIGENQGEE 210
N R +E ++ K+ EE EE+ ++ ++ E +E
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2314
Query: 211 K------GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFT--- 260
K T+++A+ E LQ+ K E+ E+ ++ +E KE++ + + +GF
Sbjct: 2315 KMQAVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2368
Query: 261 EVKSQNGEFMT---HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE--------- 308
E + Q M+ +LK SR RA D + + E G++L
Sbjct: 2369 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEK 2427
Query: 309 -------ELRRRRGETESE-----------EFEKLKQKQQEAALELEELKKKREE----- 345
E++R++ + ++E E EKL+Q+ + L+ EE++ ++E
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487
Query: 346 -----------------RRKVLEEEEQRRKQEEAD-----RKLREEEEKRRLKEEIERRR 383
R + +E+E+ + +Q D ++LREE+++++ + E ER+R
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2547
Query: 384 ----AEAAEKRQKMPEDGL 398
E A +RQ E+G+
Sbjct: 2548 LVASMEEARRRQHEAEEGV 2566
Score = 65.9 bits (159), Expect = 1e-10
Identities = 98/420 (23%), Positives = 182/420 (43%), Gaps = 33/420 (7%)
Query: 5 ERRRELRRQKREEMR-LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQV 62
E RR R ++E R L+ + A Q+ EE+A ++ QE + Q+E+S L Q+
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALE 116
+ E + + EEA+ + + ERL + EE+ Q R Q E L
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
++ E + + R+ Q AE E +K + RQ+ +E T+ ++ D
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKE---- 232
+ +++ + K E E +R +Q EE+ V+ + E+L + K + E
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQR-----SQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Query: 233 --EIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 290
KD + +E E++K + + + + E ++ A
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR----QLAEEDLAQQRALAEK 2310
Query: 291 DTKEAEGAPQVEAGKRLE-ELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 349
KE A Q + E EL +++ E E+ +L++ +++ A ++L ++ + ++
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA---QQLAEETQGFQRT 2367
Query: 350 LEEEEQRRKQ--EEADR-KLREEEEKR---RLKEEIERRRAEAAEKRQKMPEDGLSDDKK 403
LE E QR+ + EA+R KLR E R R +E+ +R R +A E +K+ L+ +K
Sbjct: 2368 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427
Score = 64.7 bits (156), Expect = 2e-10
Identities = 103/481 (21%), Positives = 196/481 (40%), Gaps = 80/481 (16%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEA-ARERRRRARQ-------------ERLRQKQ----E 55
++ E+ ++ Y R D A ++ RRR Q E+LRQ+Q E
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Query: 56 EESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ 112
E G+ ++ + A+ N++ D E + T Q+E A + + + + +Q
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVASPAKKPKVQSGSESVIQ 1314
Query: 113 EALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET 167
E ++ + + T S +S RRM+ E E +++++E R+ E+E
Sbjct: 1315 EYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALE 1370
Query: 168 VTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKP 227
+ + + + ++E KE ++ +E+ R EE Q ++ +QE+
Sbjct: 1371 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR-------EEAAVDAQQQKRSIQEELQ 1423
Query: 228 TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGR 287
++ + E K ++ + +S + ++ V+ Q L+ TE R G
Sbjct: 1424 QLRQSS-EAEIQAKARQAEAAERSRLRIEEEIRVVRLQ--------LEATER--QRGGAE 1472
Query: 288 ASVDTKEAEGAPQVEAGKRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE 345
+ A A + EA KR EE R R + + E K + + + A+ E + RE+
Sbjct: 1473 GELQALRAR-AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1531
Query: 346 RRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF 405
+R + EE R + EEA+R+LR+ E +R + ++ A E Q+ E L
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVERARQVQV------ALETAQRSAEAELQ------ 1579
Query: 406 KCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSA 463
+RA F K+ Q ++ H A + + + R +Q A + A
Sbjct: 1580 ------------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627
Query: 464 K 464
+
Sbjct: 1628 E 1628
Score = 62.0 bits (149), Expect = 1e-09
Identities = 90/402 (22%), Positives = 161/402 (40%), Gaps = 62/402 (15%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
E R+ EE RL ++ A +R E EAA E++R+ + + K + E + + +
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER--EAKELQQR 1396
Query: 69 NAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITD 127
+ V EEA + +E L + + E + + R EA ER + + I
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 128 ASLSLPSRRMQNDTAENETTEKEEKSESR--QERYEIEETETVTKSYQKNDWRDAEENKK 185
L L + Q AE E ++E Q+R EE E + + Q
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD----------- 1505
Query: 186 EDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKRE-KLQEDKPTFKKEEIKDEKIKKDKE 244
E + K + E E R EK +QA E +LQ ++ + + + E+ ++ +
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1565
Query: 245 PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE-- 302
E T +S E + + E T + E + Q E
Sbjct: 1566 ALE------------TAQRSAEAELQSKRASFAEKT------------AQLERSLQEEHV 1601
Query: 303 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE------------RRKVL 350
A +L E RR + ++E ++ ++EA ELE + K E ++K L
Sbjct: 1602 AVAQLREEAERRAQQQAEA----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1657
Query: 351 EEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 392
+ E +++EEA+R+ R + + +E+ R+R A ++ +K
Sbjct: 1658 AQAEAEKQKEEAEREAR---RRGKAEEQAVRQRELAEQELEK 1696
Score = 62.0 bits (149), Expect = 1e-09
Identities = 81/393 (20%), Positives = 173/393 (44%), Gaps = 37/393 (9%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR----ARQERLRQKQEEES 58
D + + +++ E+M+ AE A R +EAAR R+ A+Q L +K +E
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2315
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
+ V + + A+ + ++ + + +D+ ++LA + Q+ L+ ERQ
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA--ERQ 2373
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
++ + + L L M A E + + ++ + ++ TE T+ +
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE------K 2427
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQ-EDKPTFKKEEIKDE 237
E + ++ + + + R +I E + E++ + +AK +L+ E+ T ++E++ E
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487
Query: 238 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEG 297
+ E S + R++ + K++ + ++ + R + E E
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL--REEQQRQQQQMEQER 2545
Query: 298 APQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR---KVLEEEE 354
V + +EE RRR+ E E E +++KQ EEL++ ++RR ++L EE
Sbjct: 2546 QRLVAS---MEEARRRQHEAE----EGVRRKQ-------EELQQLEQQRRQQEELLAEEN 2591
Query: 355 QRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 387
QR +++ +L EE+ + L E ++ A
Sbjct: 2592 QRLREQ---LQLLEEQHRAALAHSEEVTASQVA 2621
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 85.1 bits (209), Expect = 2e-16
Identities = 112/536 (20%), Positives = 230/536 (42%), Gaps = 74/536 (13%)
Query: 7 RRELRRQKREEMRLEAERIAYQRN------DDDEEEAARERRRR--ARQERLRQKQ-EEE 57
R +L+ + +RL+AE +A Q++ + +EEA RE RRR A ++ +RQ++ E+
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660
Query: 58 SLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLER-LARREERRQKRLQEALE 116
L + E AQ + E+ +G+ + LE LAR + Q+ E
Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1720
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
+ E + + L S+ + + + + + +++ E+ R+ E +
Sbjct: 1721 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1780
Query: 177 WRDAEENKKEDKEKEEEEEEK---PKRGSIGE-----NQGEEKGTKVQAKREKLQE--DK 226
+ + +ED ++ E E+ K +IGE + E + +A+ E+L+ +
Sbjct: 1781 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1840
Query: 227 PTFKKEEIKDEKIKKDKEPKEEVK-------SFMDRKKGFTEVKSQNGEFMTHKLKHTEN 279
F++ ++++ + + +E + S ++R+KG E + + ++ +
Sbjct: 1841 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1900
Query: 280 TFSRPG-GRASV------------DTKEAEGAPQVEAGKR----LEELRRRRGETE---- 318
+F + G+A + DT ++ ++EA ++ EE RRRR E
Sbjct: 1901 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1960
Query: 319 SEEFEKLKQKQQEAALE-LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKE 377
S E+ +Q++AALE +E LK K EE R++ E EQ ++ +L +E ++RL+
Sbjct: 1961 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ---LQLAQEAAQKRLQA 2017
Query: 378 EIERRRAEAAEKRQKMPE---------DGLSDDKKPFKCFTPKGSSLKIE---------- 418
E + +K Q++ + D L + + + + +++
Sbjct: 2018 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2077
Query: 419 --ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 472
E AE L +S ++ + ++ QAA K+ EQ + + A + A+D
Sbjct: 2078 QVEEAERLKQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2132
Score = 81.3 bits (199), Expect = 2e-15
Identities = 105/450 (23%), Positives = 190/450 (42%), Gaps = 72/450 (16%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1653 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1712
Query: 46 RQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1713 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1771
Query: 95 AFLERLARREERRQKRLQEALERQK---------------EFDPTITDASLSLPSRRMQN 139
A L LA +R+++ +E RQ+ E T+A ++L + +N
Sbjct: 1772 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1831
Query: 140 D----TAENETTEKEE-KSESRQERYEIEETETVTKSYQKNDWRD----AEENKKEDKEK 190
+ AE+E ++ + ++ Q + +IEE + ++ E+ ++ ++
Sbjct: 1832 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1891
Query: 191 EEE--------EEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKD 242
EEE E+ + + G + R K Q + ++ ++ E+ ++
Sbjct: 1892 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1951
Query: 243 KEPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV 301
+E +E V KS ++ + K+ E +LK R RA ++ Q
Sbjct: 1952 REAEERVQKSLAAEEEAARQRKAALEE--VERLKAKVEEARRLRERAEQESARQLQLAQE 2009
Query: 302 EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 361
A KRL+ + ++ ++L+Q Q+ L++L+ + E R+ EE E+ R Q E
Sbjct: 2010 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2069
Query: 362 ADRKLREEEEKRRLKEEIERRRAEAAEKRQ 391
RE + RR EE ER + A E+ Q
Sbjct: 2070 -----REAAQSRRQVEEAERLKQSAEEQAQ 2094
Score = 78.2 bits (191), Expect = 2e-14
Identities = 91/412 (22%), Positives = 176/412 (42%), Gaps = 43/412 (10%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1751 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1807
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1808 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1867
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1927
Query: 170 KSYQKNDWRDAEENK--KEDKEKEEEEEEKPKRGSIGENQG--EEKGTKVQAKREKLQED 225
+S ++ + A + + E++ + E EE+ ++ E + + K + +R K + +
Sbjct: 1928 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1987
Query: 226 KPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRP 284
+ +E + E ++ + +E K +K Q + + L+ ++ +
Sbjct: 1988 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2047
Query: 285 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 344
G A + AE A + E + RR + EE E+LKQ +E A + + E
Sbjct: 2048 RGEAEAARRAAEEAEEARVQAEREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAE 2104
Query: 345 ERRKVLEEEEQRRKQEEADRKLR-------EEEEKRRLKEEIERRRAEAAEK 389
+ RK E+E RR Q E LR E E+ ++ E+ R++A+ ++
Sbjct: 2105 KLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2155
Score = 77.0 bits (188), Expect = 4e-14
Identities = 92/408 (22%), Positives = 172/408 (42%), Gaps = 33/408 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARE----RRRRARQERLRQKQEE-ESLG 60
R E QKR+ EAER+ Q D+ + + E R +A E R+KQ ++L
Sbjct: 1449 RAEEAEAQKRQAQE-EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1507
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
++ Q E + E + +E +A E ++R +K Q Q+E
Sbjct: 1508 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1567
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ A L + R AE E +E +E ER++++ E + Q +
Sbjct: 1568 H---VAVAQLREEAERRAQQQAEAERAREE--AERELERWQLKANEALRLRLQAEEVAQQ 1622
Query: 181 EE--NKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE- 237
+ + +K+KEE E E +RG E ++ Q ++ Q + T ++ ++
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1682
Query: 238 --KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEA 295
+++ + E E+ + ++ + + + T K + E ++ RA ++ A
Sbjct: 1683 LIRLRAETEQGEQQRQLLEEELARLQ---REAAAATQKRQELEAELAKV--RAEMEVLLA 1737
Query: 296 EGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQ 355
A E + E ++R E E+ F +L ++ EE K++R+ L EE+
Sbjct: 1738 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-----LAEEDA 1792
Query: 356 RRKQEEADRKLREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 396
R++ EA+R L E+ E RLK E E + + E+ +++ ED
Sbjct: 1793 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1840
Score = 75.1 bits (183), Expect = 2e-13
Identities = 98/421 (23%), Positives = 183/421 (43%), Gaps = 64/421 (15%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ-ERLRQKQEEESLGQVTD 64
R+R+L ++ R ER+ Q++ EEEAAR+R+ + ERL+ K EE +
Sbjct: 1939 RQRQLAAEEERRRREAEERV--QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 1996
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ E Q + E A+ +RL E+ +Q ++++E T
Sbjct: 1997 EQESARQLQLAQEAAQ-----------------KRLQAEEKAHAFAVQ---QKEQELQQT 2036
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVTKSYQKNDWRD 179
+ L R + + A E EE + E+ Q R ++EE E + +S ++
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2096
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQGEEK-GTKVQAKREKLQEDKPTFKKEEIKDE- 237
A+ +K ++E E+E +R + +K + ++ K ++ +K +++ E
Sbjct: 2097 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2156
Query: 238 -KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE-A 295
++ E + K+ +D + +K++ E + + E FS V +E +
Sbjct: 2157 TTLRLQLEETDHQKNLLDEE--LQRLKAEATEAARQRSQVEEELFS-----VRVQMEELS 2209
Query: 296 EGAPQVEAGKRLEELRRRRGETE--SEEFEKLKQKQQEAA--------------LELEEL 339
+ ++EA R LR + EE EK+KQ +EAA L E+L
Sbjct: 2210 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2269
Query: 340 KKKREERRKVLEE-----EEQRRKQEEAD----RKLREEEEKRRLKEEIERRRAEAAEKR 390
++R K+L+E +E R + EA+ +K +E+ RRL+E+ E+ + AE+
Sbjct: 2270 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2329
Query: 391 Q 391
Q
Sbjct: 2330 Q 2330
Score = 75.1 bits (183), Expect = 2e-13
Identities = 86/421 (20%), Positives = 181/421 (42%), Gaps = 34/421 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2205
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2206 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2265
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESR 156
+ +Q+ L E + ++K E +A L + + + A +KE+ ++
Sbjct: 2266 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2325
Query: 157 QERYE-IEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKV 215
E + + T + Q +AE K E + + Q EE G K+
Sbjct: 2326 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2385
Query: 216 QAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 275
QE + EI+ ++ D E E + ++R+K + +++ + + +++
Sbjct: 2386 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2445
Query: 276 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 335
+ +A + +E ++ + +E+ + + + +E K +Q ++E +
Sbjct: 2446 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2505
Query: 336 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMP 394
++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++
Sbjct: 2506 QQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2563
Query: 395 E 395
E
Sbjct: 2564 E 2564
Score = 69.7 bits (169), Expect = 7e-12
Identities = 109/499 (21%), Positives = 207/499 (41%), Gaps = 136/499 (27%)
Query: 13 QKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQN 72
++ EE R++AER EAA+ RR+ ERL+Q EE++ + Q
Sbjct: 2059 EEAEEARVQAER-----------EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2107
Query: 73 SVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITDASLS 131
++EA + + + A ++ A E + K+ E RQK + + +T L
Sbjct: 2108 KEAEQEAAR-----RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2162
Query: 132 LPSRRMQNDTAENETTE-KEEKSESRQERYEIEET--------ETVTKSYQK-------- 174
L Q + + E K E +E+ ++R ++EE E ++K +
Sbjct: 2163 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2222
Query: 175 ------NDWRDAEENKKEDKEKEEE------------------EEEKPKRGSIGENQGEE 210
N R +E ++ K+ EE EE+ ++ ++ E +E
Sbjct: 2223 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2282
Query: 211 K------GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFT--- 260
K T+++A+ E LQ+ K E+ E+ ++ +E KE++ + + +GF
Sbjct: 2283 KMQAVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2336
Query: 261 EVKSQNGEFMT---HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE--------- 308
E + Q M+ +LK SR RA D + + E G++L
Sbjct: 2337 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEK 2395
Query: 309 -------ELRRRRGETESE-----------EFEKLKQKQQEAALELEELKKKREE----- 345
E++R++ + ++E E EKL+Q+ + L+ EE++ ++E
Sbjct: 2396 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2455
Query: 346 -----------------RRKVLEEEEQRRKQEEAD-----RKLREEEEKRRLKEEIERRR 383
R + +E+E+ + +Q D ++LREE+++++ + E ER+R
Sbjct: 2456 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2515
Query: 384 ----AEAAEKRQKMPEDGL 398
E A +RQ E+G+
Sbjct: 2516 LVASMEEARRRQHEAEEGV 2534
Score = 65.9 bits (159), Expect = 1e-10
Identities = 98/420 (23%), Positives = 182/420 (43%), Gaps = 33/420 (7%)
Query: 5 ERRRELRRQKREEMR-LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQV 62
E RR R ++E R L+ + A Q+ EE+A ++ QE + Q+E+S L Q+
Sbjct: 1988 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2047
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALE 116
+ E + + EEA+ + + ERL + EE+ Q R Q E L
Sbjct: 2048 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2107
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
++ E + + R+ Q AE E +K + RQ+ +E T+ ++ D
Sbjct: 2108 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2167
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKE---- 232
+ +++ + K E E +R +Q EE+ V+ + E+L + K + E
Sbjct: 2168 HQKNLLDEELQRLKAEATEAARQR-----SQVEEELFSVRVQMEELSKLKARIEAENRAL 2222
Query: 233 --EIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 290
KD + +E E++K + + + + E ++ A
Sbjct: 2223 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR----QLAEEDLAQQRALAEK 2278
Query: 291 DTKEAEGAPQVEAGKRLE-ELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 349
KE A Q + E EL +++ E E+ +L++ +++ A ++L ++ + ++
Sbjct: 2279 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA---QQLAEETQGFQRT 2335
Query: 350 LEEEEQRRKQ--EEADR-KLREEEEKR---RLKEEIERRRAEAAEKRQKMPEDGLSDDKK 403
LE E QR+ + EA+R KLR E R R +E+ +R R +A E +K+ L+ +K
Sbjct: 2336 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2395
Score = 64.7 bits (156), Expect = 2e-10
Identities = 103/481 (21%), Positives = 196/481 (40%), Gaps = 80/481 (16%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEA-ARERRRRARQ-------------ERLRQKQ----E 55
++ E+ ++ Y R D A ++ RRR Q E+LRQ+Q E
Sbjct: 1166 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1225
Query: 56 EESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ 112
E G+ ++ + A+ N++ D E + T Q+E A + + + + +Q
Sbjct: 1226 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVASPAKKPKVQSGSESVIQ 1282
Query: 113 EALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET 167
E ++ + + T S +S RRM+ E E +++++E R+ E+E
Sbjct: 1283 EYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALE 1338
Query: 168 VTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKP 227
+ + + + ++E KE ++ +E+ R EE Q ++ +QE+
Sbjct: 1339 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR-------EEAAVDAQQQKRSIQEELQ 1391
Query: 228 TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGR 287
++ + E K ++ + +S + ++ V+ Q L+ TE R G
Sbjct: 1392 QLRQSS-EAEIQAKARQAEAAERSRLRIEEEIRVVRLQ--------LEATER--QRGGAE 1440
Query: 288 ASVDTKEAEGAPQVEAGKRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE 345
+ A A + EA KR EE R R + + E K + + + A+ E + RE+
Sbjct: 1441 GELQALRAR-AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1499
Query: 346 RRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF 405
+R + EE R + EEA+R+LR+ E +R + ++ A E Q+ E L
Sbjct: 1500 QRALQALEELRLQAEEAERRLRQAEVERARQVQV------ALETAQRSAEAELQ------ 1547
Query: 406 KCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSA 463
+RA F K+ Q ++ H A + + + R +Q A + A
Sbjct: 1548 ------------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1595
Query: 464 K 464
+
Sbjct: 1596 E 1596
Score = 62.0 bits (149), Expect = 1e-09
Identities = 90/402 (22%), Positives = 161/402 (40%), Gaps = 62/402 (15%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
E R+ EE RL ++ A +R E EAA E++R+ + + K + E + + +
Sbjct: 1307 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER--EAKELQQR 1364
Query: 69 NAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITD 127
+ V EEA + +E L + + E + + R EA ER + + I
Sbjct: 1365 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1424
Query: 128 ASLSLPSRRMQNDTAENETTEKEEKSESR--QERYEIEETETVTKSYQKNDWRDAEENKK 185
L L + Q AE E ++E Q+R EE E + + Q
Sbjct: 1425 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD----------- 1473
Query: 186 EDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKRE-KLQEDKPTFKKEEIKDEKIKKDKE 244
E + K + E E R EK +QA E +LQ ++ + + + E+ ++ +
Sbjct: 1474 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1533
Query: 245 PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE-- 302
E T +S E + + E T + E + Q E
Sbjct: 1534 ALE------------TAQRSAEAELQSKRASFAEKT------------AQLERSLQEEHV 1569
Query: 303 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE------------RRKVL 350
A +L E RR + ++E ++ ++EA ELE + K E ++K L
Sbjct: 1570 AVAQLREEAERRAQQQAEA----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1625
Query: 351 EEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 392
+ E +++EEA+R+ R + + +E+ R+R A ++ +K
Sbjct: 1626 AQAEAEKQKEEAEREAR---RRGKAEEQAVRQRELAEQELEK 1664
Score = 62.0 bits (149), Expect = 1e-09
Identities = 81/393 (20%), Positives = 173/393 (44%), Gaps = 37/393 (9%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR----ARQERLRQKQEEES 58
D + + +++ E+M+ AE A R +EAAR R+ A+Q L +K +E
Sbjct: 2226 DKDNTQRFLQEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2283
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
+ V + + A+ + ++ + + +D+ ++LA + Q+ L+ ERQ
Sbjct: 2284 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA--ERQ 2341
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
++ + + L L M A E + + ++ + ++ TE T+ +
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE------K 2395
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQ-EDKPTFKKEEIKDE 237
E + ++ + + + R +I E + E++ + +AK +L+ E+ T ++E++ E
Sbjct: 2396 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2455
Query: 238 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEG 297
+ E S + R++ + K++ + ++ + R + E E
Sbjct: 2456 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL--REEQQRQQQQMEQER 2513
Query: 298 APQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR---KVLEEEE 354
V + +EE RRR+ E E E +++KQ EEL++ ++RR ++L EE
Sbjct: 2514 QRLVAS---MEEARRRQHEAE----EGVRRKQ-------EELQQLEQQRRQQEELLAEEN 2559
Query: 355 QRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 387
QR +++ +L EE+ + L E ++ A
Sbjct: 2560 QRLREQ---LQLLEEQHRAALAHSEEVTASQVA 2589
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 85.1 bits (209), Expect = 2e-16
Identities = 112/536 (20%), Positives = 230/536 (42%), Gaps = 74/536 (13%)
Query: 7 RRELRRQKREEMRLEAERIAYQRN------DDDEEEAARERRRR--ARQERLRQKQ-EEE 57
R +L+ + +RL+AE +A Q++ + +EEA RE RRR A ++ +RQ++ E+
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829
Query: 58 SLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLER-LARREERRQKRLQEALE 116
L + E AQ + E+ +G+ + LE LAR + Q+ E
Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1889
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
+ E + + L S+ + + + + + +++ E+ R+ E +
Sbjct: 1890 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1949
Query: 177 WRDAEENKKEDKEKEEEEEEK---PKRGSIGE-----NQGEEKGTKVQAKREKLQE--DK 226
+ + +ED ++ E E+ K +IGE + E + +A+ E+L+ +
Sbjct: 1950 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 2009
Query: 227 PTFKKEEIKDEKIKKDKEPKEEVK-------SFMDRKKGFTEVKSQNGEFMTHKLKHTEN 279
F++ ++++ + + +E + S ++R+KG E + + ++ +
Sbjct: 2010 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 2069
Query: 280 TFSRPG-GRASV------------DTKEAEGAPQVEAGKR----LEELRRRRGETE---- 318
+F + G+A + DT ++ ++EA ++ EE RRRR E
Sbjct: 2070 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2129
Query: 319 SEEFEKLKQKQQEAALE-LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKE 377
S E+ +Q++AALE +E LK K EE R++ E EQ ++ +L +E ++RL+
Sbjct: 2130 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ---LQLAQEAAQKRLQA 2186
Query: 378 EIERRRAEAAEKRQKMPE---------DGLSDDKKPFKCFTPKGSSLKIE---------- 418
E + +K Q++ + D L + + + + +++
Sbjct: 2187 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2246
Query: 419 --ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 472
E AE L +S ++ + ++ QAA K+ EQ + + A + A+D
Sbjct: 2247 QVEEAERLKQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2301
Score = 81.3 bits (199), Expect = 2e-15
Identities = 105/450 (23%), Positives = 190/450 (42%), Gaps = 72/450 (16%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1822 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1881
Query: 46 RQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1882 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1940
Query: 95 AFLERLARREERRQKRLQEALERQK---------------EFDPTITDASLSLPSRRMQN 139
A L LA +R+++ +E RQ+ E T+A ++L + +N
Sbjct: 1941 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 2000
Query: 140 D----TAENETTEKEE-KSESRQERYEIEETETVTKSYQKNDWRD----AEENKKEDKEK 190
+ AE+E ++ + ++ Q + +IEE + ++ E+ ++ ++
Sbjct: 2001 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 2060
Query: 191 EEE--------EEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKD 242
EEE E+ + + G + R K Q + ++ ++ E+ ++
Sbjct: 2061 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2120
Query: 243 KEPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV 301
+E +E V KS ++ + K+ E +LK R RA ++ Q
Sbjct: 2121 REAEERVQKSLAAEEEAARQRKAALEE--VERLKAKVEEARRLRERAEQESARQLQLAQE 2178
Query: 302 EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 361
A KRL+ + ++ ++L+Q Q+ L++L+ + E R+ EE E+ R Q E
Sbjct: 2179 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2238
Query: 362 ADRKLREEEEKRRLKEEIERRRAEAAEKRQ 391
RE + RR EE ER + A E+ Q
Sbjct: 2239 -----REAAQSRRQVEEAERLKQSAEEQAQ 2263
Score = 78.2 bits (191), Expect = 2e-14
Identities = 91/412 (22%), Positives = 176/412 (42%), Gaps = 43/412 (10%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1920 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1977 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 2036
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 2096
Query: 170 KSYQKNDWRDAEENK--KEDKEKEEEEEEKPKRGSIGENQG--EEKGTKVQAKREKLQED 225
+S ++ + A + + E++ + E EE+ ++ E + + K + +R K + +
Sbjct: 2097 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2156
Query: 226 KPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRP 284
+ +E + E ++ + +E K +K Q + + L+ ++ +
Sbjct: 2157 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2216
Query: 285 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 344
G A + AE A + E + RR + EE E+LKQ +E A + + E
Sbjct: 2217 RGEAEAARRAAEEAEEARVQAEREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAE 2273
Query: 345 ERRKVLEEEEQRRKQEEADRKLR-------EEEEKRRLKEEIERRRAEAAEK 389
+ RK E+E RR Q E LR E E+ ++ E+ R++A+ ++
Sbjct: 2274 KLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2324
Score = 77.0 bits (188), Expect = 4e-14
Identities = 92/408 (22%), Positives = 172/408 (42%), Gaps = 33/408 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARE----RRRRARQERLRQKQEE-ESLG 60
R E QKR+ EAER+ Q D+ + + E R +A E R+KQ ++L
Sbjct: 1618 RAEEAEAQKRQAQE-EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1676
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
++ Q E + E + +E +A E ++R +K Q Q+E
Sbjct: 1677 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1736
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ A L + R AE E +E +E ER++++ E + Q +
Sbjct: 1737 H---VAVAQLREEAERRAQQQAEAERAREE--AERELERWQLKANEALRLRLQAEEVAQQ 1791
Query: 181 EE--NKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE- 237
+ + +K+KEE E E +RG E ++ Q ++ Q + T ++ ++
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1851
Query: 238 --KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEA 295
+++ + E E+ + ++ + + + T K + E ++ RA ++ A
Sbjct: 1852 LIRLRAETEQGEQQRQLLEEELARLQ---REAAAATQKRQELEAELAKV--RAEMEVLLA 1906
Query: 296 EGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQ 355
A E + E ++R E E+ F +L ++ EE K++R+ L EE+
Sbjct: 1907 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-----LAEEDA 1961
Query: 356 RRKQEEADRKLREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 396
R++ EA+R L E+ E RLK E E + + E+ +++ ED
Sbjct: 1962 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 2009
Score = 75.1 bits (183), Expect = 2e-13
Identities = 98/421 (23%), Positives = 183/421 (43%), Gaps = 64/421 (15%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ-ERLRQKQEEESLGQVTD 64
R+R+L ++ R ER+ Q++ EEEAAR+R+ + ERL+ K EE +
Sbjct: 2108 RQRQLAAEEERRRREAEERV--QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2165
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ E Q + E A+ +RL E+ +Q ++++E T
Sbjct: 2166 EQESARQLQLAQEAAQ-----------------KRLQAEEKAHAFAVQ---QKEQELQQT 2205
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVTKSYQKNDWRD 179
+ L R + + A E EE + E+ Q R ++EE E + +S ++
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2265
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQGEEK-GTKVQAKREKLQEDKPTFKKEEIKDE- 237
A+ +K ++E E+E +R + +K + ++ K ++ +K +++ E
Sbjct: 2266 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2325
Query: 238 -KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE-A 295
++ E + K+ +D + +K++ E + + E FS V +E +
Sbjct: 2326 TTLRLQLEETDHQKNLLDEE--LQRLKAEATEAARQRSQVEEELFS-----VRVQMEELS 2378
Query: 296 EGAPQVEAGKRLEELRRRRGETE--SEEFEKLKQKQQEAA--------------LELEEL 339
+ ++EA R LR + EE EK+KQ +EAA L E+L
Sbjct: 2379 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2438
Query: 340 KKKREERRKVLEE-----EEQRRKQEEAD----RKLREEEEKRRLKEEIERRRAEAAEKR 390
++R K+L+E +E R + EA+ +K +E+ RRL+E+ E+ + AE+
Sbjct: 2439 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2498
Query: 391 Q 391
Q
Sbjct: 2499 Q 2499
Score = 75.1 bits (183), Expect = 2e-13
Identities = 86/421 (20%), Positives = 181/421 (42%), Gaps = 34/421 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2374
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2375 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2434
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESR 156
+ +Q+ L E + ++K E +A L + + + A +KE+ ++
Sbjct: 2435 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2494
Query: 157 QERYE-IEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKV 215
E + + T + Q +AE K E + + Q EE G K+
Sbjct: 2495 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2554
Query: 216 QAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 275
QE + EI+ ++ D E E + ++R+K + +++ + + +++
Sbjct: 2555 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2614
Query: 276 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 335
+ +A + +E ++ + +E+ + + + +E K +Q ++E +
Sbjct: 2615 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2674
Query: 336 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMP 394
++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++
Sbjct: 2675 QQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2732
Query: 395 E 395
E
Sbjct: 2733 E 2733
Score = 69.7 bits (169), Expect = 7e-12
Identities = 109/499 (21%), Positives = 207/499 (41%), Gaps = 136/499 (27%)
Query: 13 QKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQN 72
++ EE R++AER EAA+ RR+ ERL+Q EE++ + Q
Sbjct: 2228 EEAEEARVQAER-----------EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2276
Query: 73 SVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITDASLS 131
++EA + + + A ++ A E + K+ E RQK + + +T L
Sbjct: 2277 KEAEQEAAR-----RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2331
Query: 132 LPSRRMQNDTAENETTE-KEEKSESRQERYEIEET--------ETVTKSYQK-------- 174
L Q + + E K E +E+ ++R ++EE E ++K +
Sbjct: 2332 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2391
Query: 175 ------NDWRDAEENKKEDKEKEEE------------------EEEKPKRGSIGENQGEE 210
N R +E ++ K+ EE EE+ ++ ++ E +E
Sbjct: 2392 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2451
Query: 211 K------GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFT--- 260
K T+++A+ E LQ+ K E+ E+ ++ +E KE++ + + +GF
Sbjct: 2452 KMQAVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2505
Query: 261 EVKSQNGEFMT---HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE--------- 308
E + Q M+ +LK SR RA D + + E G++L
Sbjct: 2506 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEK 2564
Query: 309 -------ELRRRRGETESE-----------EFEKLKQKQQEAALELEELKKKREE----- 345
E++R++ + ++E E EKL+Q+ + L+ EE++ ++E
Sbjct: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2624
Query: 346 -----------------RRKVLEEEEQRRKQEEAD-----RKLREEEEKRRLKEEIERRR 383
R + +E+E+ + +Q D ++LREE+++++ + E ER+R
Sbjct: 2625 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2684
Query: 384 ----AEAAEKRQKMPEDGL 398
E A +RQ E+G+
Sbjct: 2685 LVASMEEARRRQHEAEEGV 2703
Score = 65.9 bits (159), Expect = 1e-10
Identities = 98/420 (23%), Positives = 182/420 (43%), Gaps = 33/420 (7%)
Query: 5 ERRRELRRQKREEMR-LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQV 62
E RR R ++E R L+ + A Q+ EE+A ++ QE + Q+E+S L Q+
Sbjct: 2157 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2216
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALE 116
+ E + + EEA+ + + ERL + EE+ Q R Q E L
Sbjct: 2217 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2276
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
++ E + + R+ Q AE E +K + RQ+ +E T+ ++ D
Sbjct: 2277 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2336
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKE---- 232
+ +++ + K E E +R +Q EE+ V+ + E+L + K + E
Sbjct: 2337 HQKNLLDEELQRLKAEATEAARQR-----SQVEEELFSVRVQMEELSKLKARIEAENRAL 2391
Query: 233 --EIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 290
KD + +E E++K + + + + E ++ A
Sbjct: 2392 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR----QLAEEDLAQQRALAEK 2447
Query: 291 DTKEAEGAPQVEAGKRLE-ELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 349
KE A Q + E EL +++ E E+ +L++ +++ A ++L ++ + ++
Sbjct: 2448 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA---QQLAEETQGFQRT 2504
Query: 350 LEEEEQRRKQ--EEADR-KLREEEEKR---RLKEEIERRRAEAAEKRQKMPEDGLSDDKK 403
LE E QR+ + EA+R KLR E R R +E+ +R R +A E +K+ L+ +K
Sbjct: 2505 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2564
Score = 64.7 bits (156), Expect = 2e-10
Identities = 103/481 (21%), Positives = 196/481 (40%), Gaps = 80/481 (16%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEA-ARERRRRARQ-------------ERLRQKQ----E 55
++ E+ ++ Y R D A ++ RRR Q E+LRQ+Q E
Sbjct: 1335 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1394
Query: 56 EESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ 112
E G+ ++ + A+ N++ D E + T Q+E A + + + + +Q
Sbjct: 1395 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVASPAKKPKVQSGSESVIQ 1451
Query: 113 EALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET 167
E ++ + + T S +S RRM+ E E +++++E R+ E+E
Sbjct: 1452 EYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALE 1507
Query: 168 VTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKP 227
+ + + + ++E KE ++ +E+ R EE Q ++ +QE+
Sbjct: 1508 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR-------EEAAVDAQQQKRSIQEELQ 1560
Query: 228 TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGR 287
++ + E K ++ + +S + ++ V+ Q L+ TE R G
Sbjct: 1561 QLRQSS-EAEIQAKARQAEAAERSRLRIEEEIRVVRLQ--------LEATER--QRGGAE 1609
Query: 288 ASVDTKEAEGAPQVEAGKRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE 345
+ A A + EA KR EE R R + + E K + + + A+ E + RE+
Sbjct: 1610 GELQALRAR-AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1668
Query: 346 RRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF 405
+R + EE R + EEA+R+LR+ E +R + ++ A E Q+ E L
Sbjct: 1669 QRALQALEELRLQAEEAERRLRQAEVERARQVQV------ALETAQRSAEAELQ------ 1716
Query: 406 KCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSA 463
+RA F K+ Q ++ H A + + + R +Q A + A
Sbjct: 1717 ------------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1764
Query: 464 K 464
+
Sbjct: 1765 E 1765
Score = 62.0 bits (149), Expect = 1e-09
Identities = 90/402 (22%), Positives = 161/402 (40%), Gaps = 62/402 (15%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
E R+ EE RL ++ A +R E EAA E++R+ + + K + E + + +
Sbjct: 1476 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER--EAKELQQR 1533
Query: 69 NAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITD 127
+ V EEA + +E L + + E + + R EA ER + + I
Sbjct: 1534 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1593
Query: 128 ASLSLPSRRMQNDTAENETTEKEEKSESR--QERYEIEETETVTKSYQKNDWRDAEENKK 185
L L + Q AE E ++E Q+R EE E + + Q
Sbjct: 1594 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD----------- 1642
Query: 186 EDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKRE-KLQEDKPTFKKEEIKDEKIKKDKE 244
E + K + E E R EK +QA E +LQ ++ + + + E+ ++ +
Sbjct: 1643 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1702
Query: 245 PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE-- 302
E T +S E + + E T + E + Q E
Sbjct: 1703 ALE------------TAQRSAEAELQSKRASFAEKT------------AQLERSLQEEHV 1738
Query: 303 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE------------RRKVL 350
A +L E RR + ++E ++ ++EA ELE + K E ++K L
Sbjct: 1739 AVAQLREEAERRAQQQAEA----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1794
Query: 351 EEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 392
+ E +++EEA+R+ R + + +E+ R+R A ++ +K
Sbjct: 1795 AQAEAEKQKEEAEREAR---RRGKAEEQAVRQRELAEQELEK 1833
Score = 62.0 bits (149), Expect = 1e-09
Identities = 81/393 (20%), Positives = 173/393 (44%), Gaps = 37/393 (9%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR----ARQERLRQKQEEES 58
D + + +++ E+M+ AE A R +EAAR R+ A+Q L +K +E
Sbjct: 2395 DKDNTQRFLQEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2452
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
+ V + + A+ + ++ + + +D+ ++LA + Q+ L+ ERQ
Sbjct: 2453 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA--ERQ 2510
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
++ + + L L M A E + + ++ + ++ TE T+ +
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE------K 2564
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQ-EDKPTFKKEEIKDE 237
E + ++ + + + R +I E + E++ + +AK +L+ E+ T ++E++ E
Sbjct: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2624
Query: 238 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEG 297
+ E S + R++ + K++ + ++ + R + E E
Sbjct: 2625 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL--REEQQRQQQQMEQER 2682
Query: 298 APQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR---KVLEEEE 354
V + +EE RRR+ E E E +++KQ EEL++ ++RR ++L EE
Sbjct: 2683 QRLVAS---MEEARRRQHEAE----EGVRRKQ-------EELQQLEQQRRQQEELLAEEN 2728
Query: 355 QRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 387
QR +++ +L EE+ + L E ++ A
Sbjct: 2729 QRLREQ---LQLLEEQHRAALAHSEEVTASQVA 2758
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 85.1 bits (209), Expect = 2e-16
Identities = 112/536 (20%), Positives = 230/536 (42%), Gaps = 74/536 (13%)
Query: 7 RRELRRQKREEMRLEAERIAYQRN------DDDEEEAARERRRR--ARQERLRQKQ-EEE 57
R +L+ + +RL+AE +A Q++ + +EEA RE RRR A ++ +RQ++ E+
Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1670
Query: 58 SLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLER-LARREERRQKRLQEALE 116
L + E AQ + E+ +G+ + LE LAR + Q+ E
Sbjct: 1671 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1730
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
+ E + + L S+ + + + + + +++ E+ R+ E +
Sbjct: 1731 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1790
Query: 177 WRDAEENKKEDKEKEEEEEEK---PKRGSIGE-----NQGEEKGTKVQAKREKLQE--DK 226
+ + +ED ++ E E+ K +IGE + E + +A+ E+L+ +
Sbjct: 1791 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1850
Query: 227 PTFKKEEIKDEKIKKDKEPKEEVK-------SFMDRKKGFTEVKSQNGEFMTHKLKHTEN 279
F++ ++++ + + +E + S ++R+KG E + + ++ +
Sbjct: 1851 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1910
Query: 280 TFSRPG-GRASV------------DTKEAEGAPQVEAGKR----LEELRRRRGETE---- 318
+F + G+A + DT ++ ++EA ++ EE RRRR E
Sbjct: 1911 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1970
Query: 319 SEEFEKLKQKQQEAALE-LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKE 377
S E+ +Q++AALE +E LK K EE R++ E EQ ++ +L +E ++RL+
Sbjct: 1971 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ---LQLAQEAAQKRLQA 2027
Query: 378 EIERRRAEAAEKRQKMPE---------DGLSDDKKPFKCFTPKGSSLKIE---------- 418
E + +K Q++ + D L + + + + +++
Sbjct: 2028 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2087
Query: 419 --ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 472
E AE L +S ++ + ++ QAA K+ EQ + + A + A+D
Sbjct: 2088 QVEEAERLKQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2142
Score = 81.3 bits (199), Expect = 2e-15
Identities = 105/450 (23%), Positives = 190/450 (42%), Gaps = 72/450 (16%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1663 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1722
Query: 46 RQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1723 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1781
Query: 95 AFLERLARREERRQKRLQEALERQK---------------EFDPTITDASLSLPSRRMQN 139
A L LA +R+++ +E RQ+ E T+A ++L + +N
Sbjct: 1782 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1841
Query: 140 D----TAENETTEKEE-KSESRQERYEIEETETVTKSYQKNDWRD----AEENKKEDKEK 190
+ AE+E ++ + ++ Q + +IEE + ++ E+ ++ ++
Sbjct: 1842 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1901
Query: 191 EEE--------EEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKD 242
EEE E+ + + G + R K Q + ++ ++ E+ ++
Sbjct: 1902 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1961
Query: 243 KEPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV 301
+E +E V KS ++ + K+ E +LK R RA ++ Q
Sbjct: 1962 REAEERVQKSLAAEEEAARQRKAALEE--VERLKAKVEEARRLRERAEQESARQLQLAQE 2019
Query: 302 EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 361
A KRL+ + ++ ++L+Q Q+ L++L+ + E R+ EE E+ R Q E
Sbjct: 2020 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2079
Query: 362 ADRKLREEEEKRRLKEEIERRRAEAAEKRQ 391
RE + RR EE ER + A E+ Q
Sbjct: 2080 -----REAAQSRRQVEEAERLKQSAEEQAQ 2104
Score = 78.2 bits (191), Expect = 2e-14
Identities = 91/412 (22%), Positives = 176/412 (42%), Gaps = 43/412 (10%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1761 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1817
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1818 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1877
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1937
Query: 170 KSYQKNDWRDAEENK--KEDKEKEEEEEEKPKRGSIGENQG--EEKGTKVQAKREKLQED 225
+S ++ + A + + E++ + E EE+ ++ E + + K + +R K + +
Sbjct: 1938 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1997
Query: 226 KPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRP 284
+ +E + E ++ + +E K +K Q + + L+ ++ +
Sbjct: 1998 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2057
Query: 285 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 344
G A + AE A + E + RR + EE E+LKQ +E A + + E
Sbjct: 2058 RGEAEAARRAAEEAEEARVQAEREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAE 2114
Query: 345 ERRKVLEEEEQRRKQEEADRKLR-------EEEEKRRLKEEIERRRAEAAEK 389
+ RK E+E RR Q E LR E E+ ++ E+ R++A+ ++
Sbjct: 2115 KLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2165
Score = 77.0 bits (188), Expect = 4e-14
Identities = 92/408 (22%), Positives = 172/408 (42%), Gaps = 33/408 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARE----RRRRARQERLRQKQEE-ESLG 60
R E QKR+ EAER+ Q D+ + + E R +A E R+KQ ++L
Sbjct: 1459 RAEEAEAQKRQAQE-EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1517
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
++ Q E + E + +E +A E ++R +K Q Q+E
Sbjct: 1518 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1577
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ A L + R AE E +E +E ER++++ E + Q +
Sbjct: 1578 H---VAVAQLREEAERRAQQQAEAERAREE--AERELERWQLKANEALRLRLQAEEVAQQ 1632
Query: 181 EE--NKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE- 237
+ + +K+KEE E E +RG E ++ Q ++ Q + T ++ ++
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1692
Query: 238 --KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEA 295
+++ + E E+ + ++ + + + T K + E ++ RA ++ A
Sbjct: 1693 LIRLRAETEQGEQQRQLLEEELARLQ---REAAAATQKRQELEAELAKV--RAEMEVLLA 1747
Query: 296 EGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQ 355
A E + E ++R E E+ F +L ++ EE K++R+ L EE+
Sbjct: 1748 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-----LAEEDA 1802
Query: 356 RRKQEEADRKLREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 396
R++ EA+R L E+ E RLK E E + + E+ +++ ED
Sbjct: 1803 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1850
Score = 75.1 bits (183), Expect = 2e-13
Identities = 98/421 (23%), Positives = 183/421 (43%), Gaps = 64/421 (15%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ-ERLRQKQEEESLGQVTD 64
R+R+L ++ R ER+ Q++ EEEAAR+R+ + ERL+ K EE +
Sbjct: 1949 RQRQLAAEEERRRREAEERV--QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2006
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ E Q + E A+ +RL E+ +Q ++++E T
Sbjct: 2007 EQESARQLQLAQEAAQ-----------------KRLQAEEKAHAFAVQ---QKEQELQQT 2046
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVTKSYQKNDWRD 179
+ L R + + A E EE + E+ Q R ++EE E + +S ++
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2106
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQGEEK-GTKVQAKREKLQEDKPTFKKEEIKDE- 237
A+ +K ++E E+E +R + +K + ++ K ++ +K +++ E
Sbjct: 2107 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2166
Query: 238 -KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE-A 295
++ E + K+ +D + +K++ E + + E FS V +E +
Sbjct: 2167 TTLRLQLEETDHQKNLLDEE--LQRLKAEATEAARQRSQVEEELFS-----VRVQMEELS 2219
Query: 296 EGAPQVEAGKRLEELRRRRGETE--SEEFEKLKQKQQEAA--------------LELEEL 339
+ ++EA R LR + EE EK+KQ +EAA L E+L
Sbjct: 2220 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2279
Query: 340 KKKREERRKVLEE-----EEQRRKQEEAD----RKLREEEEKRRLKEEIERRRAEAAEKR 390
++R K+L+E +E R + EA+ +K +E+ RRL+E+ E+ + AE+
Sbjct: 2280 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2339
Query: 391 Q 391
Q
Sbjct: 2340 Q 2340
Score = 75.1 bits (183), Expect = 2e-13
Identities = 86/421 (20%), Positives = 181/421 (42%), Gaps = 34/421 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2215
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2216 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2275
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESR 156
+ +Q+ L E + ++K E +A L + + + A +KE+ ++
Sbjct: 2276 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2335
Query: 157 QERYE-IEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKV 215
E + + T + Q +AE K E + + Q EE G K+
Sbjct: 2336 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2395
Query: 216 QAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 275
QE + EI+ ++ D E E + ++R+K + +++ + + +++
Sbjct: 2396 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2455
Query: 276 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 335
+ +A + +E ++ + +E+ + + + +E K +Q ++E +
Sbjct: 2456 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2515
Query: 336 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMP 394
++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++
Sbjct: 2516 QQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2573
Query: 395 E 395
E
Sbjct: 2574 E 2574
Score = 69.7 bits (169), Expect = 7e-12
Identities = 109/499 (21%), Positives = 207/499 (41%), Gaps = 136/499 (27%)
Query: 13 QKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQN 72
++ EE R++AER EAA+ RR+ ERL+Q EE++ + Q
Sbjct: 2069 EEAEEARVQAER-----------EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2117
Query: 73 SVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITDASLS 131
++EA + + + A ++ A E + K+ E RQK + + +T L
Sbjct: 2118 KEAEQEAAR-----RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2172
Query: 132 LPSRRMQNDTAENETTE-KEEKSESRQERYEIEET--------ETVTKSYQK-------- 174
L Q + + E K E +E+ ++R ++EE E ++K +
Sbjct: 2173 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2232
Query: 175 ------NDWRDAEENKKEDKEKEEE------------------EEEKPKRGSIGENQGEE 210
N R +E ++ K+ EE EE+ ++ ++ E +E
Sbjct: 2233 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2292
Query: 211 K------GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFT--- 260
K T+++A+ E LQ+ K E+ E+ ++ +E KE++ + + +GF
Sbjct: 2293 KMQAVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2346
Query: 261 EVKSQNGEFMT---HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE--------- 308
E + Q M+ +LK SR RA D + + E G++L
Sbjct: 2347 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEK 2405
Query: 309 -------ELRRRRGETESE-----------EFEKLKQKQQEAALELEELKKKREE----- 345
E++R++ + ++E E EKL+Q+ + L+ EE++ ++E
Sbjct: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2465
Query: 346 -----------------RRKVLEEEEQRRKQEEAD-----RKLREEEEKRRLKEEIERRR 383
R + +E+E+ + +Q D ++LREE+++++ + E ER+R
Sbjct: 2466 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2525
Query: 384 ----AEAAEKRQKMPEDGL 398
E A +RQ E+G+
Sbjct: 2526 LVASMEEARRRQHEAEEGV 2544
Score = 65.9 bits (159), Expect = 1e-10
Identities = 98/420 (23%), Positives = 182/420 (43%), Gaps = 33/420 (7%)
Query: 5 ERRRELRRQKREEMR-LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQV 62
E RR R ++E R L+ + A Q+ EE+A ++ QE + Q+E+S L Q+
Sbjct: 1998 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2057
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALE 116
+ E + + EEA+ + + ERL + EE+ Q R Q E L
Sbjct: 2058 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2117
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
++ E + + R+ Q AE E +K + RQ+ +E T+ ++ D
Sbjct: 2118 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2177
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKE---- 232
+ +++ + K E E +R +Q EE+ V+ + E+L + K + E
Sbjct: 2178 HQKNLLDEELQRLKAEATEAARQR-----SQVEEELFSVRVQMEELSKLKARIEAENRAL 2232
Query: 233 --EIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 290
KD + +E E++K + + + + E ++ A
Sbjct: 2233 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR----QLAEEDLAQQRALAEK 2288
Query: 291 DTKEAEGAPQVEAGKRLE-ELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 349
KE A Q + E EL +++ E E+ +L++ +++ A ++L ++ + ++
Sbjct: 2289 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA---QQLAEETQGFQRT 2345
Query: 350 LEEEEQRRKQ--EEADR-KLREEEEKR---RLKEEIERRRAEAAEKRQKMPEDGLSDDKK 403
LE E QR+ + EA+R KLR E R R +E+ +R R +A E +K+ L+ +K
Sbjct: 2346 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2405
Score = 64.7 bits (156), Expect = 2e-10
Identities = 103/481 (21%), Positives = 196/481 (40%), Gaps = 80/481 (16%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEA-ARERRRRARQ-------------ERLRQKQ----E 55
++ E+ ++ Y R D A ++ RRR Q E+LRQ+Q E
Sbjct: 1176 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1235
Query: 56 EESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ 112
E G+ ++ + A+ N++ D E + T Q+E A + + + + +Q
Sbjct: 1236 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVASPAKKPKVQSGSESVIQ 1292
Query: 113 EALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET 167
E ++ + + T S +S RRM+ E E +++++E R+ E+E
Sbjct: 1293 EYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALE 1348
Query: 168 VTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKP 227
+ + + + ++E KE ++ +E+ R EE Q ++ +QE+
Sbjct: 1349 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR-------EEAAVDAQQQKRSIQEELQ 1401
Query: 228 TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGR 287
++ + E K ++ + +S + ++ V+ Q L+ TE R G
Sbjct: 1402 QLRQSS-EAEIQAKARQAEAAERSRLRIEEEIRVVRLQ--------LEATER--QRGGAE 1450
Query: 288 ASVDTKEAEGAPQVEAGKRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE 345
+ A A + EA KR EE R R + + E K + + + A+ E + RE+
Sbjct: 1451 GELQALRAR-AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1509
Query: 346 RRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF 405
+R + EE R + EEA+R+LR+ E +R + ++ A E Q+ E L
Sbjct: 1510 QRALQALEELRLQAEEAERRLRQAEVERARQVQV------ALETAQRSAEAELQ------ 1557
Query: 406 KCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSA 463
+RA F K+ Q ++ H A + + + R +Q A + A
Sbjct: 1558 ------------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1605
Query: 464 K 464
+
Sbjct: 1606 E 1606
Score = 62.0 bits (149), Expect = 1e-09
Identities = 90/402 (22%), Positives = 161/402 (40%), Gaps = 62/402 (15%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
E R+ EE RL ++ A +R E EAA E++R+ + + K + E + + +
Sbjct: 1317 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER--EAKELQQR 1374
Query: 69 NAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITD 127
+ V EEA + +E L + + E + + R EA ER + + I
Sbjct: 1375 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1434
Query: 128 ASLSLPSRRMQNDTAENETTEKEEKSESR--QERYEIEETETVTKSYQKNDWRDAEENKK 185
L L + Q AE E ++E Q+R EE E + + Q
Sbjct: 1435 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD----------- 1483
Query: 186 EDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKRE-KLQEDKPTFKKEEIKDEKIKKDKE 244
E + K + E E R EK +QA E +LQ ++ + + + E+ ++ +
Sbjct: 1484 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1543
Query: 245 PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE-- 302
E T +S E + + E T + E + Q E
Sbjct: 1544 ALE------------TAQRSAEAELQSKRASFAEKT------------AQLERSLQEEHV 1579
Query: 303 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE------------RRKVL 350
A +L E RR + ++E ++ ++EA ELE + K E ++K L
Sbjct: 1580 AVAQLREEAERRAQQQAEA----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1635
Query: 351 EEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 392
+ E +++EEA+R+ R + + +E+ R+R A ++ +K
Sbjct: 1636 AQAEAEKQKEEAEREAR---RRGKAEEQAVRQRELAEQELEK 1674
Score = 62.0 bits (149), Expect = 1e-09
Identities = 81/393 (20%), Positives = 173/393 (44%), Gaps = 37/393 (9%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR----ARQERLRQKQEEES 58
D + + +++ E+M+ AE A R +EAAR R+ A+Q L +K +E
Sbjct: 2236 DKDNTQRFLQEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2293
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
+ V + + A+ + ++ + + +D+ ++LA + Q+ L+ ERQ
Sbjct: 2294 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA--ERQ 2351
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
++ + + L L M A E + + ++ + ++ TE T+ +
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE------K 2405
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQ-EDKPTFKKEEIKDE 237
E + ++ + + + R +I E + E++ + +AK +L+ E+ T ++E++ E
Sbjct: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2465
Query: 238 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEG 297
+ E S + R++ + K++ + ++ + R + E E
Sbjct: 2466 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL--REEQQRQQQQMEQER 2523
Query: 298 APQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR---KVLEEEE 354
V + +EE RRR+ E E E +++KQ EEL++ ++RR ++L EE
Sbjct: 2524 QRLVAS---MEEARRRQHEAE----EGVRRKQ-------EELQQLEQQRRQQEELLAEEN 2569
Query: 355 QRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 387
QR +++ +L EE+ + L E ++ A
Sbjct: 2570 QRLREQ---LQLLEEQHRAALAHSEEVTASQVA 2599
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 85.1 bits (209), Expect = 2e-16
Identities = 112/536 (20%), Positives = 230/536 (42%), Gaps = 74/536 (13%)
Query: 7 RRELRRQKREEMRLEAERIAYQRN------DDDEEEAARERRRR--ARQERLRQKQ-EEE 57
R +L+ + +RL+AE +A Q++ + +EEA RE RRR A ++ +RQ++ E+
Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1678
Query: 58 SLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLER-LARREERRQKRLQEALE 116
L + E AQ + E+ +G+ + LE LAR + Q+ E
Sbjct: 1679 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1738
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
+ E + + L S+ + + + + + +++ E+ R+ E +
Sbjct: 1739 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1798
Query: 177 WRDAEENKKEDKEKEEEEEEK---PKRGSIGE-----NQGEEKGTKVQAKREKLQE--DK 226
+ + +ED ++ E E+ K +IGE + E + +A+ E+L+ +
Sbjct: 1799 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1858
Query: 227 PTFKKEEIKDEKIKKDKEPKEEVK-------SFMDRKKGFTEVKSQNGEFMTHKLKHTEN 279
F++ ++++ + + +E + S ++R+KG E + + ++ +
Sbjct: 1859 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1918
Query: 280 TFSRPG-GRASV------------DTKEAEGAPQVEAGKR----LEELRRRRGETE---- 318
+F + G+A + DT ++ ++EA ++ EE RRRR E
Sbjct: 1919 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1978
Query: 319 SEEFEKLKQKQQEAALE-LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKE 377
S E+ +Q++AALE +E LK K EE R++ E EQ ++ +L +E ++RL+
Sbjct: 1979 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ---LQLAQEAAQKRLQA 2035
Query: 378 EIERRRAEAAEKRQKMPE---------DGLSDDKKPFKCFTPKGSSLKIE---------- 418
E + +K Q++ + D L + + + + +++
Sbjct: 2036 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2095
Query: 419 --ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 472
E AE L +S ++ + ++ QAA K+ EQ + + A + A+D
Sbjct: 2096 QVEEAERLKQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2150
Score = 81.3 bits (199), Expect = 2e-15
Identities = 105/450 (23%), Positives = 190/450 (42%), Gaps = 72/450 (16%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1671 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1730
Query: 46 RQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1731 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1789
Query: 95 AFLERLARREERRQKRLQEALERQK---------------EFDPTITDASLSLPSRRMQN 139
A L LA +R+++ +E RQ+ E T+A ++L + +N
Sbjct: 1790 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1849
Query: 140 D----TAENETTEKEE-KSESRQERYEIEETETVTKSYQKNDWRD----AEENKKEDKEK 190
+ AE+E ++ + ++ Q + +IEE + ++ E+ ++ ++
Sbjct: 1850 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1909
Query: 191 EEE--------EEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKD 242
EEE E+ + + G + R K Q + ++ ++ E+ ++
Sbjct: 1910 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1969
Query: 243 KEPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV 301
+E +E V KS ++ + K+ E +LK R RA ++ Q
Sbjct: 1970 REAEERVQKSLAAEEEAARQRKAALEE--VERLKAKVEEARRLRERAEQESARQLQLAQE 2027
Query: 302 EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 361
A KRL+ + ++ ++L+Q Q+ L++L+ + E R+ EE E+ R Q E
Sbjct: 2028 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2087
Query: 362 ADRKLREEEEKRRLKEEIERRRAEAAEKRQ 391
RE + RR EE ER + A E+ Q
Sbjct: 2088 -----REAAQSRRQVEEAERLKQSAEEQAQ 2112
Score = 78.2 bits (191), Expect = 2e-14
Identities = 91/412 (22%), Positives = 176/412 (42%), Gaps = 43/412 (10%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1769 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1825
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1826 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1885
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1886 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1945
Query: 170 KSYQKNDWRDAEENK--KEDKEKEEEEEEKPKRGSIGENQG--EEKGTKVQAKREKLQED 225
+S ++ + A + + E++ + E EE+ ++ E + + K + +R K + +
Sbjct: 1946 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2005
Query: 226 KPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRP 284
+ +E + E ++ + +E K +K Q + + L+ ++ +
Sbjct: 2006 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2065
Query: 285 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 344
G A + AE A + E + RR + EE E+LKQ +E A + + E
Sbjct: 2066 RGEAEAARRAAEEAEEARVQAEREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAE 2122
Query: 345 ERRKVLEEEEQRRKQEEADRKLR-------EEEEKRRLKEEIERRRAEAAEK 389
+ RK E+E RR Q E LR E E+ ++ E+ R++A+ ++
Sbjct: 2123 KLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2173
Score = 77.0 bits (188), Expect = 4e-14
Identities = 92/408 (22%), Positives = 172/408 (42%), Gaps = 33/408 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARE----RRRRARQERLRQKQEE-ESLG 60
R E QKR+ EAER+ Q D+ + + E R +A E R+KQ ++L
Sbjct: 1467 RAEEAEAQKRQAQE-EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1525
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
++ Q E + E + +E +A E ++R +K Q Q+E
Sbjct: 1526 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1585
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ A L + R AE E +E +E ER++++ E + Q +
Sbjct: 1586 H---VAVAQLREEAERRAQQQAEAERAREE--AERELERWQLKANEALRLRLQAEEVAQQ 1640
Query: 181 EE--NKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE- 237
+ + +K+KEE E E +RG E ++ Q ++ Q + T ++ ++
Sbjct: 1641 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1700
Query: 238 --KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEA 295
+++ + E E+ + ++ + + + T K + E ++ RA ++ A
Sbjct: 1701 LIRLRAETEQGEQQRQLLEEELARLQ---REAAAATQKRQELEAELAKV--RAEMEVLLA 1755
Query: 296 EGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQ 355
A E + E ++R E E+ F +L ++ EE K++R+ L EE+
Sbjct: 1756 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-----LAEEDA 1810
Query: 356 RRKQEEADRKLREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 396
R++ EA+R L E+ E RLK E E + + E+ +++ ED
Sbjct: 1811 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1858
Score = 75.1 bits (183), Expect = 2e-13
Identities = 98/421 (23%), Positives = 183/421 (43%), Gaps = 64/421 (15%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ-ERLRQKQEEESLGQVTD 64
R+R+L ++ R ER+ Q++ EEEAAR+R+ + ERL+ K EE +
Sbjct: 1957 RQRQLAAEEERRRREAEERV--QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2014
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ E Q + E A+ +RL E+ +Q ++++E T
Sbjct: 2015 EQESARQLQLAQEAAQ-----------------KRLQAEEKAHAFAVQ---QKEQELQQT 2054
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVTKSYQKNDWRD 179
+ L R + + A E EE + E+ Q R ++EE E + +S ++
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2114
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQGEEK-GTKVQAKREKLQEDKPTFKKEEIKDE- 237
A+ +K ++E E+E +R + +K + ++ K ++ +K +++ E
Sbjct: 2115 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2174
Query: 238 -KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE-A 295
++ E + K+ +D + +K++ E + + E FS V +E +
Sbjct: 2175 TTLRLQLEETDHQKNLLDEE--LQRLKAEATEAARQRSQVEEELFS-----VRVQMEELS 2227
Query: 296 EGAPQVEAGKRLEELRRRRGETE--SEEFEKLKQKQQEAA--------------LELEEL 339
+ ++EA R LR + EE EK+KQ +EAA L E+L
Sbjct: 2228 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2287
Query: 340 KKKREERRKVLEE-----EEQRRKQEEAD----RKLREEEEKRRLKEEIERRRAEAAEKR 390
++R K+L+E +E R + EA+ +K +E+ RRL+E+ E+ + AE+
Sbjct: 2288 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2347
Query: 391 Q 391
Q
Sbjct: 2348 Q 2348
Score = 75.1 bits (183), Expect = 2e-13
Identities = 86/421 (20%), Positives = 181/421 (42%), Gaps = 34/421 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2165 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2223
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2224 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2283
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESR 156
+ +Q+ L E + ++K E +A L + + + A +KE+ ++
Sbjct: 2284 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2343
Query: 157 QERYE-IEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKV 215
E + + T + Q +AE K E + + Q EE G K+
Sbjct: 2344 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2403
Query: 216 QAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 275
QE + EI+ ++ D E E + ++R+K + +++ + + +++
Sbjct: 2404 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2463
Query: 276 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 335
+ +A + +E ++ + +E+ + + + +E K +Q ++E +
Sbjct: 2464 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2523
Query: 336 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMP 394
++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++
Sbjct: 2524 QQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2581
Query: 395 E 395
E
Sbjct: 2582 E 2582
Score = 69.7 bits (169), Expect = 7e-12
Identities = 109/499 (21%), Positives = 207/499 (41%), Gaps = 136/499 (27%)
Query: 13 QKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQN 72
++ EE R++AER EAA+ RR+ ERL+Q EE++ + Q
Sbjct: 2077 EEAEEARVQAER-----------EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2125
Query: 73 SVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITDASLS 131
++EA + + + A ++ A E + K+ E RQK + + +T L
Sbjct: 2126 KEAEQEAAR-----RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2180
Query: 132 LPSRRMQNDTAENETTE-KEEKSESRQERYEIEET--------ETVTKSYQK-------- 174
L Q + + E K E +E+ ++R ++EE E ++K +
Sbjct: 2181 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2240
Query: 175 ------NDWRDAEENKKEDKEKEEE------------------EEEKPKRGSIGENQGEE 210
N R +E ++ K+ EE EE+ ++ ++ E +E
Sbjct: 2241 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2300
Query: 211 K------GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFT--- 260
K T+++A+ E LQ+ K E+ E+ ++ +E KE++ + + +GF
Sbjct: 2301 KMQAVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2354
Query: 261 EVKSQNGEFMT---HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE--------- 308
E + Q M+ +LK SR RA D + + E G++L
Sbjct: 2355 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEK 2413
Query: 309 -------ELRRRRGETESE-----------EFEKLKQKQQEAALELEELKKKREE----- 345
E++R++ + ++E E EKL+Q+ + L+ EE++ ++E
Sbjct: 2414 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2473
Query: 346 -----------------RRKVLEEEEQRRKQEEAD-----RKLREEEEKRRLKEEIERRR 383
R + +E+E+ + +Q D ++LREE+++++ + E ER+R
Sbjct: 2474 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2533
Query: 384 ----AEAAEKRQKMPEDGL 398
E A +RQ E+G+
Sbjct: 2534 LVASMEEARRRQHEAEEGV 2552
Score = 65.9 bits (159), Expect = 1e-10
Identities = 98/420 (23%), Positives = 182/420 (43%), Gaps = 33/420 (7%)
Query: 5 ERRRELRRQKREEMR-LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQV 62
E RR R ++E R L+ + A Q+ EE+A ++ QE + Q+E+S L Q+
Sbjct: 2006 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2065
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALE 116
+ E + + EEA+ + + ERL + EE+ Q R Q E L
Sbjct: 2066 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2125
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
++ E + + R+ Q AE E +K + RQ+ +E T+ ++ D
Sbjct: 2126 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2185
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKE---- 232
+ +++ + K E E +R +Q EE+ V+ + E+L + K + E
Sbjct: 2186 HQKNLLDEELQRLKAEATEAARQR-----SQVEEELFSVRVQMEELSKLKARIEAENRAL 2240
Query: 233 --EIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 290
KD + +E E++K + + + + E ++ A
Sbjct: 2241 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR----QLAEEDLAQQRALAEK 2296
Query: 291 DTKEAEGAPQVEAGKRLE-ELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 349
KE A Q + E EL +++ E E+ +L++ +++ A ++L ++ + ++
Sbjct: 2297 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA---QQLAEETQGFQRT 2353
Query: 350 LEEEEQRRKQ--EEADR-KLREEEEKR---RLKEEIERRRAEAAEKRQKMPEDGLSDDKK 403
LE E QR+ + EA+R KLR E R R +E+ +R R +A E +K+ L+ +K
Sbjct: 2354 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2413
Score = 64.7 bits (156), Expect = 2e-10
Identities = 103/481 (21%), Positives = 196/481 (40%), Gaps = 80/481 (16%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEA-ARERRRRARQ-------------ERLRQKQ----E 55
++ E+ ++ Y R D A ++ RRR Q E+LRQ+Q E
Sbjct: 1184 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1243
Query: 56 EESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ 112
E G+ ++ + A+ N++ D E + T Q+E A + + + + +Q
Sbjct: 1244 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVASPAKKPKVQSGSESVIQ 1300
Query: 113 EALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET 167
E ++ + + T S +S RRM+ E E +++++E R+ E+E
Sbjct: 1301 EYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALE 1356
Query: 168 VTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKP 227
+ + + + ++E KE ++ +E+ R EE Q ++ +QE+
Sbjct: 1357 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR-------EEAAVDAQQQKRSIQEELQ 1409
Query: 228 TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGR 287
++ + E K ++ + +S + ++ V+ Q L+ TE R G
Sbjct: 1410 QLRQSS-EAEIQAKARQAEAAERSRLRIEEEIRVVRLQ--------LEATER--QRGGAE 1458
Query: 288 ASVDTKEAEGAPQVEAGKRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE 345
+ A A + EA KR EE R R + + E K + + + A+ E + RE+
Sbjct: 1459 GELQALRAR-AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1517
Query: 346 RRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF 405
+R + EE R + EEA+R+LR+ E +R + ++ A E Q+ E L
Sbjct: 1518 QRALQALEELRLQAEEAERRLRQAEVERARQVQV------ALETAQRSAEAELQ------ 1565
Query: 406 KCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSA 463
+RA F K+ Q ++ H A + + + R +Q A + A
Sbjct: 1566 ------------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1613
Query: 464 K 464
+
Sbjct: 1614 E 1614
Score = 62.0 bits (149), Expect = 1e-09
Identities = 90/402 (22%), Positives = 161/402 (40%), Gaps = 62/402 (15%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
E R+ EE RL ++ A +R E EAA E++R+ + + K + E + + +
Sbjct: 1325 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER--EAKELQQR 1382
Query: 69 NAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITD 127
+ V EEA + +E L + + E + + R EA ER + + I
Sbjct: 1383 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1442
Query: 128 ASLSLPSRRMQNDTAENETTEKEEKSESR--QERYEIEETETVTKSYQKNDWRDAEENKK 185
L L + Q AE E ++E Q+R EE E + + Q
Sbjct: 1443 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD----------- 1491
Query: 186 EDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKRE-KLQEDKPTFKKEEIKDEKIKKDKE 244
E + K + E E R EK +QA E +LQ ++ + + + E+ ++ +
Sbjct: 1492 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1551
Query: 245 PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE-- 302
E T +S E + + E T + E + Q E
Sbjct: 1552 ALE------------TAQRSAEAELQSKRASFAEKT------------AQLERSLQEEHV 1587
Query: 303 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE------------RRKVL 350
A +L E RR + ++E ++ ++EA ELE + K E ++K L
Sbjct: 1588 AVAQLREEAERRAQQQAEA----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1643
Query: 351 EEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 392
+ E +++EEA+R+ R + + +E+ R+R A ++ +K
Sbjct: 1644 AQAEAEKQKEEAEREAR---RRGKAEEQAVRQRELAEQELEK 1682
Score = 62.0 bits (149), Expect = 1e-09
Identities = 81/393 (20%), Positives = 173/393 (44%), Gaps = 37/393 (9%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR----ARQERLRQKQEEES 58
D + + +++ E+M+ AE A R +EAAR R+ A+Q L +K +E
Sbjct: 2244 DKDNTQRFLQEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2301
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
+ V + + A+ + ++ + + +D+ ++LA + Q+ L+ ERQ
Sbjct: 2302 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA--ERQ 2359
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
++ + + L L M A E + + ++ + ++ TE T+ +
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE------K 2413
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQ-EDKPTFKKEEIKDE 237
E + ++ + + + R +I E + E++ + +AK +L+ E+ T ++E++ E
Sbjct: 2414 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2473
Query: 238 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEG 297
+ E S + R++ + K++ + ++ + R + E E
Sbjct: 2474 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL--REEQQRQQQQMEQER 2531
Query: 298 APQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR---KVLEEEE 354
V + +EE RRR+ E E E +++KQ EEL++ ++RR ++L EE
Sbjct: 2532 QRLVAS---MEEARRRQHEAE----EGVRRKQ-------EELQQLEQQRRQQEELLAEEN 2577
Query: 355 QRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 387
QR +++ +L EE+ + L E ++ A
Sbjct: 2578 QRLREQ---LQLLEEQHRAALAHSEEVTASQVA 2607
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 85.1 bits (209), Expect = 2e-16
Identities = 112/536 (20%), Positives = 230/536 (42%), Gaps = 74/536 (13%)
Query: 7 RRELRRQKREEMRLEAERIAYQRN------DDDEEEAARERRRR--ARQERLRQKQ-EEE 57
R +L+ + +RL+AE +A Q++ + +EEA RE RRR A ++ +RQ++ E+
Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1719
Query: 58 SLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLER-LARREERRQKRLQEALE 116
L + E AQ + E+ +G+ + LE LAR + Q+ E
Sbjct: 1720 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1779
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
+ E + + L S+ + + + + + +++ E+ R+ E +
Sbjct: 1780 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1839
Query: 177 WRDAEENKKEDKEKEEEEEEK---PKRGSIGE-----NQGEEKGTKVQAKREKLQE--DK 226
+ + +ED ++ E E+ K +IGE + E + +A+ E+L+ +
Sbjct: 1840 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1899
Query: 227 PTFKKEEIKDEKIKKDKEPKEEVK-------SFMDRKKGFTEVKSQNGEFMTHKLKHTEN 279
F++ ++++ + + +E + S ++R+KG E + + ++ +
Sbjct: 1900 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1959
Query: 280 TFSRPG-GRASV------------DTKEAEGAPQVEAGKR----LEELRRRRGETE---- 318
+F + G+A + DT ++ ++EA ++ EE RRRR E
Sbjct: 1960 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2019
Query: 319 SEEFEKLKQKQQEAALE-LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKE 377
S E+ +Q++AALE +E LK K EE R++ E EQ ++ +L +E ++RL+
Sbjct: 2020 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ---LQLAQEAAQKRLQA 2076
Query: 378 EIERRRAEAAEKRQKMPE---------DGLSDDKKPFKCFTPKGSSLKIE---------- 418
E + +K Q++ + D L + + + + +++
Sbjct: 2077 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2136
Query: 419 --ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 472
E AE L +S ++ + ++ QAA K+ EQ + + A + A+D
Sbjct: 2137 QVEEAERLKQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2191
Score = 81.3 bits (199), Expect = 2e-15
Identities = 105/450 (23%), Positives = 190/450 (42%), Gaps = 72/450 (16%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1712 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1771
Query: 46 RQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1772 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1830
Query: 95 AFLERLARREERRQKRLQEALERQK---------------EFDPTITDASLSLPSRRMQN 139
A L LA +R+++ +E RQ+ E T+A ++L + +N
Sbjct: 1831 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1890
Query: 140 D----TAENETTEKEE-KSESRQERYEIEETETVTKSYQKNDWRD----AEENKKEDKEK 190
+ AE+E ++ + ++ Q + +IEE + ++ E+ ++ ++
Sbjct: 1891 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1950
Query: 191 EEE--------EEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKD 242
EEE E+ + + G + R K Q + ++ ++ E+ ++
Sbjct: 1951 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2010
Query: 243 KEPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV 301
+E +E V KS ++ + K+ E +LK R RA ++ Q
Sbjct: 2011 REAEERVQKSLAAEEEAARQRKAALEE--VERLKAKVEEARRLRERAEQESARQLQLAQE 2068
Query: 302 EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 361
A KRL+ + ++ ++L+Q Q+ L++L+ + E R+ EE E+ R Q E
Sbjct: 2069 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2128
Query: 362 ADRKLREEEEKRRLKEEIERRRAEAAEKRQ 391
RE + RR EE ER + A E+ Q
Sbjct: 2129 -----REAAQSRRQVEEAERLKQSAEEQAQ 2153
Score = 78.2 bits (191), Expect = 2e-14
Identities = 91/412 (22%), Positives = 176/412 (42%), Gaps = 43/412 (10%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1810 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1866
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1867 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1926
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1927 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1986
Query: 170 KSYQKNDWRDAEENK--KEDKEKEEEEEEKPKRGSIGENQG--EEKGTKVQAKREKLQED 225
+S ++ + A + + E++ + E EE+ ++ E + + K + +R K + +
Sbjct: 1987 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2046
Query: 226 KPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRP 284
+ +E + E ++ + +E K +K Q + + L+ ++ +
Sbjct: 2047 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2106
Query: 285 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 344
G A + AE A + E + RR + EE E+LKQ +E A + + E
Sbjct: 2107 RGEAEAARRAAEEAEEARVQAEREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAE 2163
Query: 345 ERRKVLEEEEQRRKQEEADRKLR-------EEEEKRRLKEEIERRRAEAAEK 389
+ RK E+E RR Q E LR E E+ ++ E+ R++A+ ++
Sbjct: 2164 KLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2214
Score = 77.0 bits (188), Expect = 4e-14
Identities = 92/408 (22%), Positives = 172/408 (42%), Gaps = 33/408 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARE----RRRRARQERLRQKQEE-ESLG 60
R E QKR+ EAER+ Q D+ + + E R +A E R+KQ ++L
Sbjct: 1508 RAEEAEAQKRQAQE-EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1566
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
++ Q E + E + +E +A E ++R +K Q Q+E
Sbjct: 1567 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1626
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ A L + R AE E +E +E ER++++ E + Q +
Sbjct: 1627 H---VAVAQLREEAERRAQQQAEAERAREE--AERELERWQLKANEALRLRLQAEEVAQQ 1681
Query: 181 EE--NKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE- 237
+ + +K+KEE E E +RG E ++ Q ++ Q + T ++ ++
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1741
Query: 238 --KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEA 295
+++ + E E+ + ++ + + + T K + E ++ RA ++ A
Sbjct: 1742 LIRLRAETEQGEQQRQLLEEELARLQ---REAAAATQKRQELEAELAKV--RAEMEVLLA 1796
Query: 296 EGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQ 355
A E + E ++R E E+ F +L ++ EE K++R+ L EE+
Sbjct: 1797 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-----LAEEDA 1851
Query: 356 RRKQEEADRKLREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 396
R++ EA+R L E+ E RLK E E + + E+ +++ ED
Sbjct: 1852 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1899
Score = 75.1 bits (183), Expect = 2e-13
Identities = 98/421 (23%), Positives = 183/421 (43%), Gaps = 64/421 (15%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ-ERLRQKQEEESLGQVTD 64
R+R+L ++ R ER+ Q++ EEEAAR+R+ + ERL+ K EE +
Sbjct: 1998 RQRQLAAEEERRRREAEERV--QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2055
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ E Q + E A+ +RL E+ +Q ++++E T
Sbjct: 2056 EQESARQLQLAQEAAQ-----------------KRLQAEEKAHAFAVQ---QKEQELQQT 2095
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVTKSYQKNDWRD 179
+ L R + + A E EE + E+ Q R ++EE E + +S ++
Sbjct: 2096 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2155
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQGEEK-GTKVQAKREKLQEDKPTFKKEEIKDE- 237
A+ +K ++E E+E +R + +K + ++ K ++ +K +++ E
Sbjct: 2156 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2215
Query: 238 -KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE-A 295
++ E + K+ +D + +K++ E + + E FS V +E +
Sbjct: 2216 TTLRLQLEETDHQKNLLDEE--LQRLKAEATEAARQRSQVEEELFS-----VRVQMEELS 2268
Query: 296 EGAPQVEAGKRLEELRRRRGETE--SEEFEKLKQKQQEAA--------------LELEEL 339
+ ++EA R LR + EE EK+KQ +EAA L E+L
Sbjct: 2269 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2328
Query: 340 KKKREERRKVLEE-----EEQRRKQEEAD----RKLREEEEKRRLKEEIERRRAEAAEKR 390
++R K+L+E +E R + EA+ +K +E+ RRL+E+ E+ + AE+
Sbjct: 2329 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2388
Query: 391 Q 391
Q
Sbjct: 2389 Q 2389
Score = 75.1 bits (183), Expect = 2e-13
Identities = 86/421 (20%), Positives = 181/421 (42%), Gaps = 34/421 (8%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2206 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2264
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2265 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2324
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESR 156
+ +Q+ L E + ++K E +A L + + + A +KE+ ++
Sbjct: 2325 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2384
Query: 157 QERYE-IEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKV 215
E + + T + Q +AE K E + + Q EE G K+
Sbjct: 2385 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2444
Query: 216 QAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 275
QE + EI+ ++ D E E + ++R+K + +++ + + +++
Sbjct: 2445 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2504
Query: 276 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 335
+ +A + +E ++ + +E+ + + + +E K +Q ++E +
Sbjct: 2505 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2564
Query: 336 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMP 394
++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++
Sbjct: 2565 QQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2622
Query: 395 E 395
E
Sbjct: 2623 E 2623
Score = 69.7 bits (169), Expect = 7e-12
Identities = 109/499 (21%), Positives = 207/499 (41%), Gaps = 136/499 (27%)
Query: 13 QKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQN 72
++ EE R++AER EAA+ RR+ ERL+Q EE++ + Q
Sbjct: 2118 EEAEEARVQAER-----------EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2166
Query: 73 SVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITDASLS 131
++EA + + + A ++ A E + K+ E RQK + + +T L
Sbjct: 2167 KEAEQEAAR-----RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2221
Query: 132 LPSRRMQNDTAENETTE-KEEKSESRQERYEIEET--------ETVTKSYQK-------- 174
L Q + + E K E +E+ ++R ++EE E ++K +
Sbjct: 2222 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2281
Query: 175 ------NDWRDAEENKKEDKEKEEE------------------EEEKPKRGSIGENQGEE 210
N R +E ++ K+ EE EE+ ++ ++ E +E
Sbjct: 2282 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2341
Query: 211 K------GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFT--- 260
K T+++A+ E LQ+ K E+ E+ ++ +E KE++ + + +GF
Sbjct: 2342 KMQAVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2395
Query: 261 EVKSQNGEFMT---HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE--------- 308
E + Q M+ +LK SR RA D + + E G++L
Sbjct: 2396 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEK 2454
Query: 309 -------ELRRRRGETESE-----------EFEKLKQKQQEAALELEELKKKREE----- 345
E++R++ + ++E E EKL+Q+ + L+ EE++ ++E
Sbjct: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2514
Query: 346 -----------------RRKVLEEEEQRRKQEEAD-----RKLREEEEKRRLKEEIERRR 383
R + +E+E+ + +Q D ++LREE+++++ + E ER+R
Sbjct: 2515 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2574
Query: 384 ----AEAAEKRQKMPEDGL 398
E A +RQ E+G+
Sbjct: 2575 LVASMEEARRRQHEAEEGV 2593
Score = 65.9 bits (159), Expect = 1e-10
Identities = 98/420 (23%), Positives = 182/420 (43%), Gaps = 33/420 (7%)
Query: 5 ERRRELRRQKREEMR-LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQV 62
E RR R ++E R L+ + A Q+ EE+A ++ QE + Q+E+S L Q+
Sbjct: 2047 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2106
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALE 116
+ E + + EEA+ + + ERL + EE+ Q R Q E L
Sbjct: 2107 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2166
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
++ E + + R+ Q AE E +K + RQ+ +E T+ ++ D
Sbjct: 2167 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2226
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKE---- 232
+ +++ + K E E +R +Q EE+ V+ + E+L + K + E
Sbjct: 2227 HQKNLLDEELQRLKAEATEAARQR-----SQVEEELFSVRVQMEELSKLKARIEAENRAL 2281
Query: 233 --EIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 290
KD + +E E++K + + + + E ++ A
Sbjct: 2282 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR----QLAEEDLAQQRALAEK 2337
Query: 291 DTKEAEGAPQVEAGKRLE-ELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 349
KE A Q + E EL +++ E E+ +L++ +++ A ++L ++ + ++
Sbjct: 2338 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA---QQLAEETQGFQRT 2394
Query: 350 LEEEEQRRKQ--EEADR-KLREEEEKR---RLKEEIERRRAEAAEKRQKMPEDGLSDDKK 403
LE E QR+ + EA+R KLR E R R +E+ +R R +A E +K+ L+ +K
Sbjct: 2395 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2454
Score = 64.7 bits (156), Expect = 2e-10
Identities = 103/481 (21%), Positives = 196/481 (40%), Gaps = 80/481 (16%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEA-ARERRRRARQ-------------ERLRQKQ----E 55
++ E+ ++ Y R D A ++ RRR Q E+LRQ+Q E
Sbjct: 1225 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1284
Query: 56 EESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ 112
E G+ ++ + A+ N++ D E + T Q+E A + + + + +Q
Sbjct: 1285 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVASPAKKPKVQSGSESVIQ 1341
Query: 113 EALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET 167
E ++ + + T S +S RRM+ E E +++++E R+ E+E
Sbjct: 1342 EYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALE 1397
Query: 168 VTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKP 227
+ + + + ++E KE ++ +E+ R EE Q ++ +QE+
Sbjct: 1398 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR-------EEAAVDAQQQKRSIQEELQ 1450
Query: 228 TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGR 287
++ + E K ++ + +S + ++ V+ Q L+ TE R G
Sbjct: 1451 QLRQSS-EAEIQAKARQAEAAERSRLRIEEEIRVVRLQ--------LEATER--QRGGAE 1499
Query: 288 ASVDTKEAEGAPQVEAGKRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE 345
+ A A + EA KR EE R R + + E K + + + A+ E + RE+
Sbjct: 1500 GELQALRAR-AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1558
Query: 346 RRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF 405
+R + EE R + EEA+R+LR+ E +R + ++ A E Q+ E L
Sbjct: 1559 QRALQALEELRLQAEEAERRLRQAEVERARQVQV------ALETAQRSAEAELQ------ 1606
Query: 406 KCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSA 463
+RA F K+ Q ++ H A + + + R +Q A + A
Sbjct: 1607 ------------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1654
Query: 464 K 464
+
Sbjct: 1655 E 1655
Score = 62.0 bits (149), Expect = 1e-09
Identities = 90/402 (22%), Positives = 161/402 (40%), Gaps = 62/402 (15%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
E R+ EE RL ++ A +R E EAA E++R+ + + K + E + + +
Sbjct: 1366 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER--EAKELQQR 1423
Query: 69 NAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITD 127
+ V EEA + +E L + + E + + R EA ER + + I
Sbjct: 1424 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1483
Query: 128 ASLSLPSRRMQNDTAENETTEKEEKSESR--QERYEIEETETVTKSYQKNDWRDAEENKK 185
L L + Q AE E ++E Q+R EE E + + Q
Sbjct: 1484 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD----------- 1532
Query: 186 EDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKRE-KLQEDKPTFKKEEIKDEKIKKDKE 244
E + K + E E R EK +QA E +LQ ++ + + + E+ ++ +
Sbjct: 1533 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1592
Query: 245 PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE-- 302
E T +S E + + E T + E + Q E
Sbjct: 1593 ALE------------TAQRSAEAELQSKRASFAEKT------------AQLERSLQEEHV 1628
Query: 303 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE------------RRKVL 350
A +L E RR + ++E ++ ++EA ELE + K E ++K L
Sbjct: 1629 AVAQLREEAERRAQQQAEA----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1684
Query: 351 EEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 392
+ E +++EEA+R+ R + + +E+ R+R A ++ +K
Sbjct: 1685 AQAEAEKQKEEAEREAR---RRGKAEEQAVRQRELAEQELEK 1723
Score = 62.0 bits (149), Expect = 1e-09
Identities = 81/393 (20%), Positives = 173/393 (44%), Gaps = 37/393 (9%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR----ARQERLRQKQEEES 58
D + + +++ E+M+ AE A R +EAAR R+ A+Q L +K +E
Sbjct: 2285 DKDNTQRFLQEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2342
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
+ V + + A+ + ++ + + +D+ ++LA + Q+ L+ ERQ
Sbjct: 2343 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA--ERQ 2400
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
++ + + L L M A E + + ++ + ++ TE T+ +
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE------K 2454
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQ-EDKPTFKKEEIKDE 237
E + ++ + + + R +I E + E++ + +AK +L+ E+ T ++E++ E
Sbjct: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2514
Query: 238 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEG 297
+ E S + R++ + K++ + ++ + R + E E
Sbjct: 2515 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL--REEQQRQQQQMEQER 2572
Query: 298 APQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR---KVLEEEE 354
V + +EE RRR+ E E E +++KQ EEL++ ++RR ++L EE
Sbjct: 2573 QRLVAS---MEEARRRQHEAE----EGVRRKQ-------EELQQLEQQRRQQEELLAEEN 2618
Query: 355 QRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 387
QR +++ +L EE+ + L E ++ A
Sbjct: 2619 QRLREQ---LQLLEEQHRAALAHSEEVTASQVA 2648
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.303 0.122 0.319
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,044,920
Number of Sequences: 37866
Number of extensions: 1328926
Number of successful extensions: 61387
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1184
Number of HSP's successfully gapped in prelim test: 1527
Number of HSP's that attempted gapping in prelim test: 9965
Number of HSP's gapped (non-prelim): 16978
length of query: 564
length of database: 18,247,518
effective HSP length: 108
effective length of query: 456
effective length of database: 14,157,990
effective search space: 6456043440
effective search space used: 6456043440
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.