Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 15147240
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15147240 brother of CDO [Homo sapiens]
(1114 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15147240 brother of CDO [Homo sapiens] 2290 0.0
gi|142976733 surface glycoprotein, Ig superfamily member [Homo s... 478 e-134
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 189 1e-47
gi|157311649 neogenin homolog 1 [Homo sapiens] 184 4e-46
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 178 2e-44
gi|28373129 contactin 5 isoform short [Homo sapiens] 178 3e-44
gi|7657359 contactin 5 isoform long [Homo sapiens] 176 1e-43
gi|83281200 protogenin [Homo sapiens] 163 7e-40
gi|4827022 contactin 2 precursor [Homo sapiens] 148 2e-35
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [... 147 4e-35
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 145 2e-34
gi|222352127 sidekick 2 [Homo sapiens] 144 6e-34
gi|75709184 contactin 3 [Homo sapiens] 139 2e-32
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 138 3e-32
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 137 4e-32
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 137 4e-32
gi|109150416 peroxidasin [Homo sapiens] 137 6e-32
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 135 2e-31
gi|118572606 hemicentin 1 [Homo sapiens] 134 5e-31
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 133 1e-30
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 133 1e-30
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 132 2e-30
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 130 9e-30
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 130 9e-30
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap... 127 4e-29
gi|126517478 peroxidasin homolog-like [Homo sapiens] 127 6e-29
gi|7657361 contactin 6 [Homo sapiens] 122 1e-27
gi|110349719 titin isoform N2-A [Homo sapiens] 122 2e-27
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 120 9e-27
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 119 1e-26
>gi|15147240 brother of CDO [Homo sapiens]
Length = 1114
Score = 2290 bits (5934), Expect = 0.0
Identities = 1114/1114 (100%), Positives = 1114/1114 (100%)
Query: 1 MLRGTMTAWRGMRPEVTLACLLLATAGCFADLNEVPQVTVQPASTVQKPGGTVILGCVVE 60
MLRGTMTAWRGMRPEVTLACLLLATAGCFADLNEVPQVTVQPASTVQKPGGTVILGCVVE
Sbjct: 1 MLRGTMTAWRGMRPEVTLACLLLATAGCFADLNEVPQVTVQPASTVQKPGGTVILGCVVE 60
Query: 61 PPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPA 120
PPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPA
Sbjct: 61 PPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPA 120
Query: 121 TVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIM 180
TVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIM
Sbjct: 121 TVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIM 180
Query: 181 PSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTI 240
PSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTI
Sbjct: 181 PSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTI 240
Query: 241 IVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCM 300
IVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCM
Sbjct: 241 IVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCM 300
Query: 301 ADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNA 360
ADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNA
Sbjct: 301 ADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNA 360
Query: 361 VPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQD 420
VPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQD
Sbjct: 361 VPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQD 420
Query: 421 AELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSS 480
AELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSS
Sbjct: 421 AELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSS 480
Query: 481 PRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLD 540
PRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLD
Sbjct: 481 PRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLD 540
Query: 541 PGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDH 600
PGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDH
Sbjct: 541 PGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDH 600
Query: 601 GRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIP 660
GRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIP
Sbjct: 601 GRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIP 660
Query: 661 PSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITF 720
PSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITF
Sbjct: 661 PSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITF 720
Query: 721 TDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHL 780
TDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHL
Sbjct: 721 TDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHL 780
Query: 781 QPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIERP 840
QPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIERP
Sbjct: 781 QPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIERP 840
Query: 841 VGTGAMVARSSDLPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALPPS 900
VGTGAMVARSSDLPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALPPS
Sbjct: 841 VGTGAMVARSSDLPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALPPS 900
Query: 901 CPYTMVPLGGLPGHQASGQPYLSGISGRACANGIHMNRGCPSAAVGYPGMKPQQHCPGEL 960
CPYTMVPLGGLPGHQASGQPYLSGISGRACANGIHMNRGCPSAAVGYPGMKPQQHCPGEL
Sbjct: 901 CPYTMVPLGGLPGHQASGQPYLSGISGRACANGIHMNRGCPSAAVGYPGMKPQQHCPGEL 960
Query: 961 QQQSDTSSLLRQTHLGNGYDPQSHQITRGPKSSPDEGSFLYTLPDDSTHQLLQPHHDCCQ 1020
QQQSDTSSLLRQTHLGNGYDPQSHQITRGPKSSPDEGSFLYTLPDDSTHQLLQPHHDCCQ
Sbjct: 961 QQQSDTSSLLRQTHLGNGYDPQSHQITRGPKSSPDEGSFLYTLPDDSTHQLLQPHHDCCQ 1020
Query: 1021 RQEQPAAVGQSGVRRAPDSPVLEAVWDPPFHSGPPCCLGLVPVEEVDSPDSCQVSGGDWC 1080
RQEQPAAVGQSGVRRAPDSPVLEAVWDPPFHSGPPCCLGLVPVEEVDSPDSCQVSGGDWC
Sbjct: 1021 RQEQPAAVGQSGVRRAPDSPVLEAVWDPPFHSGPPCCLGLVPVEEVDSPDSCQVSGGDWC 1080
Query: 1081 PQHPVGAYVGQEPGMQLSPGPLVRVSFETPPLTI 1114
PQHPVGAYVGQEPGMQLSPGPLVRVSFETPPLTI
Sbjct: 1081 PQHPVGAYVGQEPGMQLSPGPLVRVSFETPPLTI 1114
>gi|142976733 surface glycoprotein, Ig superfamily member [Homo
sapiens]
Length = 1264
Score = 478 bits (1231), Expect = e-134
Identities = 337/888 (37%), Positives = 448/888 (50%), Gaps = 85/888 (9%)
Query: 55 LGCVVEP--PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPA 112
+GC V P+ V +++ GK L S + +++ G L I ++ G Y+C A P
Sbjct: 139 IGCRVPESNPKAEVRYKIRGKWLEHSTENY-LILPSGNLQILNVSLEDKGSYKCAAYNPV 197
Query: 113 GAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLP-------ESHPKAQVRYSV 165
V + D H++ + P P QV Y +
Sbjct: 198 THQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQV-YWL 256
Query: 166 KQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRST 225
K A N+ + S +L + D G Y C A N SG + +
Sbjct: 257 KDGQDIAPGSNWRRLYS-HLATDSVDPADSGNYSCMAGNK-------SGDVKYVTYMVNV 308
Query: 226 AEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLL 285
E A I + Q IV+ G ++ C G P P TW + + + + L
Sbjct: 309 LEHASISKGLQDQ--IVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNGLK 366
Query: 286 IDTTSEEDSGTYRCMADNGVG--QPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLT 343
I + ED G Y+C+ADNG+G + + N F+P +T +S V G L+
Sbjct: 367 ISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVAD-GDFVTLS 425
Query: 344 CEVRGNPPPSVLWLRNAVPLIS---------SQRLRLSR------------------RAL 376
C G P P + W + + S S++ +LSR +L
Sbjct: 426 CNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSL 485
Query: 377 RVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLG 436
+ ++ E G Y C A NE G+ A L P T + L SK
Sbjct: 486 HIQAVTQEHAGKYICEAANEHGTTQAEASLMVV-PFETNTKAETVTLPDAAQNDDRSKRD 544
Query: 437 NPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPA--EAPIILSSPRTSKTDSYELVWR 494
E L L P V P++ + EK + +APIILS P+T D+Y LVWR
Sbjct: 545 GSETGL-----LSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWR 599
Query: 495 PRHEGSGRAPILYYVVKHRKVTNSSD---DWTISGIPANQHRLTLTRLDPGSLYEVEMAA 551
+G PI Y VK+RK+ + W +P +++ L L L+P SLYEV M A
Sbjct: 600 AGKDGG--LPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVA 657
Query: 552 YNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPG------ASPQSSSQ-----PDH 600
+ AGEGQ AM+TFRT K + +SK Q G S +++ D
Sbjct: 658 RSAAGEGQPAMLTFRTS---KEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDS 714
Query: 601 GRLSP-PEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAI 659
R S PEAPDRPTISTASETSVYVTWIPR NGG PI +F+VEYK+++ +W++A I
Sbjct: 715 SRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMR-TSNWLVAAEDI 773
Query: 660 PPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYIT 719
PPS+LSVE+ LE G++YKFRV A+N GES S+ SRPY V G+ R RP+ GP+I
Sbjct: 774 PPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIA 833
Query: 720 FTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISH 779
+T+AV++T IMLKW YIP+SNNNTPI GFYIYYRPTDSDNDSDYK+D+VEG K WH I H
Sbjct: 834 YTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGH 893
Query: 780 LQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIER 839
LQPETSYDIKMQCFNEGGESEFSNVMICETK ++ PG P PP
Sbjct: 894 LQPETSYDIKMQCFNEGGESEFSNVMICETKVKR---VPGASEYPVKDLSTPPNSLGSGG 950
Query: 840 PVGTGAMVARSSDLPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHT 887
VG ARSSD+ YLIVG VLG +VLI++ FI CLW+ ++Q++T
Sbjct: 951 NVGPATSPARSSDMLYLIVGCVLGVMVLILMVFIAMCLWK--NRQQNT 996
Score = 302 bits (773), Expect = 1e-81
Identities = 161/399 (40%), Positives = 230/399 (57%), Gaps = 8/399 (2%)
Query: 12 MRPEVTLACLLL---ATAGCFADLNEV-PQVTVQPASTVQKPGGTVILGCVVEPPRMNVT 67
M P++ C LL T C + +++ P T +P S VQK GG V+L C +P ++
Sbjct: 1 MHPDLGPLCTLLYVTLTILCSSVSSDLAPYFTSEPLSAVQKLGGPVVLHCSAQPVTTRIS 60
Query: 68 WRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANL 127
W NGK L+G+ + V I GTL I +LN+ +G YQC+A GA+ S PATV++A L
Sbjct: 61 WLHNGKTLDGNLEH--VKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVL 118
Query: 128 QDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQI 187
DF +HVI +E + I C +PES+PKA+VRY ++ +WLE S NYLI+PSGNLQI
Sbjct: 119 GDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQI 178
Query: 188 VNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQS 247
+N S ED+G YKCAAYNPVT ++K +L V R +++ I++P +Q + V
Sbjct: 179 LNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSP 238
Query: 248 LILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQ 307
+ LECV SG+P P+V W KDG + + R L S+L D+ DSG Y CMA N G
Sbjct: 239 VTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGD 298
Query: 308 PGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQ 367
+ Y V V E ++ L ++ G + TC+V GNP P+ W NA P+ S
Sbjct: 299 --VKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSA 356
Query: 368 RLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQL 406
R + L++ + ED G+YQC+A+N +G H+ +L
Sbjct: 357 RHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRL 395
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 189 bits (481), Expect = 1e-47
Identities = 189/782 (24%), Positives = 313/782 (40%), Gaps = 124/782 (15%)
Query: 41 QPASTVQKPGGTVILGCVVEPPR--MNVTWRLNGKELNGSDDALGVLITHGTLVITAL-- 96
+P+ V GG V+L C E R + W+ +G L D +++G+L+I +
Sbjct: 45 EPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILH 104
Query: 97 ---NNHTVGRYQCVARM-PAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHL 152
+ G YQC A + +G++ S A V +A F + V G+T ++ C +
Sbjct: 105 SRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAF-MGDTVLLKCEV 163
Query: 153 PESHPKAQVRYSVKQEWLEASRGN--YLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEV 210
P + + Q+ L G+ +++PSG LQI D G+Y+C+A NP +
Sbjct: 164 I-GEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSR- 221
Query: 211 KTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSS 270
+G+ +R+ ++ + ++ +G+ +LEC SG PPP TW +
Sbjct: 222 --TGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEV 279
Query: 271 VTGYNKTRFLL--SNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTME 328
+ +K LL SNLLI +++DSG Y C+ A+ L V PP
Sbjct: 280 IQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAEL---TVLVPPWFLNH 336
Query: 329 LSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRA-LRVLSMGPEDEG 387
S L + C V G P P+V W++N +I S ++ + LR+L + DEG
Sbjct: 337 PSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEG 396
Query: 388 VYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPA 447
YQC+AENE G+A QL +P+I
Sbjct: 397 FYQCVAENEAGNAQTSAQLIVPKPAI---------------------------------- 422
Query: 448 LPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILY 507
P +SV P++P+ P+++SS L WRP E G +
Sbjct: 423 ---PSSSVLPSAPR----------DVVPVLVSS------RFVRLSWRPPAEAKGNIQ-TF 462
Query: 508 YVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRT 567
V R+ N + ++ +LT+ L P ++Y + AYN G G+++
Sbjct: 463 TVFFSREGDNR--ERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQ----- 515
Query: 568 GRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWI 627
I + + ++Q P + Q+ S S TS+ +TW
Sbjct: 516 ------PIKVATQPELQVPGPVENLQAVS--------------------TSPTSILITWE 549
Query: 628 PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNML 687
P P+Q +R+ ++ + I LS ++ GL+K T Y R A N
Sbjct: 550 PPAYANGPVQGYRLFCTEVSTGKE-----QNIEVDGLSYKLEGLKKFTEYSLRFLAYNRY 604
Query: 688 GESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHG 747
G P + V S + P A P + VN +I + W+ P+ N I G
Sbjct: 605 G---PGVSTDDITVVTLS----DVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITG 657
Query: 748 FYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMIC 807
+ I +R T + + +E + W+ + L+ + Y ++ G SN
Sbjct: 658 YKIRHRKTTRRGE----METLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTA 713
Query: 808 ET 809
ET
Sbjct: 714 ET 715
Score = 49.7 bits (117), Expect = 2e-05
Identities = 78/379 (20%), Positives = 144/379 (37%), Gaps = 42/379 (11%)
Query: 527 IPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRD 586
+ + Q ++ RL+ S Y + + A+N AGEG + T P + D
Sbjct: 774 VDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLD-D 832
Query: 587 DPGASPQSSSQPDHGRLSPPEAPDRPTISTA-SETSVYVTW----IPRGNGGFPIQSFRV 641
P +S PD LS P P + A + +V V+W +P+ ++ + V
Sbjct: 833 FP------TSVPD---LSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTV 883
Query: 642 EYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVV 701
++ + + LS TGL+ T Y+F V + S + +
Sbjct: 884 RWRTSFSASAKYKSEDT---TSLSYTATGLKPNTMYEFSVMVTK-------NRRSSTWSM 933
Query: 702 SGYSGRVYERPVAGP--YITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDN 759
+ ++ P + P T +++ W P N I + ++Y +
Sbjct: 934 TAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQ--PPLEANGKITAYILFYTLDKNIP 991
Query: 760 DSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICET----KARKSS 815
D+ + + GD+ H I L +T Y ++Q N G S+ ++ T K +
Sbjct: 992 IDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMA 1051
Query: 816 GQPGRLPPPTLAPPQPPLPETI---ERPVGT-----GAMVARSSDLPYLIVGVVLGSI-V 866
GR P L + E P+G G++ + + +I+ V +G I V
Sbjct: 1052 NDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITV 1111
Query: 867 LIIVTFIPFCLWRAWSKQK 885
L++V C R+ ++Q+
Sbjct: 1112 LVVVIVAVICTRRSSAQQR 1130
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 184 bits (467), Expect = 4e-46
Identities = 215/845 (25%), Positives = 331/845 (39%), Gaps = 158/845 (18%)
Query: 6 MTAWRGMR-----PEVTLACLLL----ATAGCFADLNEVPQ-------------VTVQPA 43
M A RG R P L CLLL A A PQ V+P
Sbjct: 1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV 60
Query: 44 STVQKPGGTVILGC-VVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITAL-----N 97
T+ G +VIL C P + W+ +G LN D L+ G+L I+ + N
Sbjct: 61 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN 120
Query: 98 NHTVGRYQCVARMPA-GAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESH 156
G YQCVA + + G + S A + +A L F + V GN A++ C + +
Sbjct: 121 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPS-SVYAGNNAILNCEV-NAD 178
Query: 157 PKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSS 216
VR+ ++ L + +PSG L I NA++ D G+Y+C V + S
Sbjct: 179 LVPFVRWEQNRQPLLLD-DRVIKLPSGMLVISNATEGDGGLYRC-----VVESGGPPKYS 232
Query: 217 DR--LRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGY 274
D L+V + +++ + ++ GQ ++L CVASG+P P + W K+ ++
Sbjct: 233 DEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTE 292
Query: 275 NKTRFLL---SNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQ 331
+ R +L +L I +E+D+GTY C+ADNG A L V PE + +
Sbjct: 293 SSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAEL---TVQAQPEFLKQPTN 349
Query: 332 LVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRA-LRVLSMGPEDEGVYQ 390
+ CEV G P P+V W++N +I S ++ + L+VL + DEG YQ
Sbjct: 350 IYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQ 409
Query: 391 CMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPR 450
C+AEN+VG+A A QL L
Sbjct: 410 CIAENDVGNAQAGAQL---------------------------------------IILEH 430
Query: 451 PPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYV- 509
P + GP AP + L S R K L WR + Y V
Sbjct: 431 APATTGPL---------PSAPRDVVASLVSTRFIK-----LTWRTPASDPHGDNLTYSVF 476
Query: 510 -----VKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVT 564
+ +V N+S + ++T+ L P ++Y + A N G G+++
Sbjct: 477 YTKEGIARERVENTSH--------PGEMQVTIQNLMPATVYIFRVMAQNKHGSGESS-AP 527
Query: 565 FRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYV 624
R +P+ ++ PG +P + AS TS+ V
Sbjct: 528 LRVETQPEVQL------------PGPAPNLRAY------------------AASPTSITV 557
Query: 625 TWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRAL 684
TW +G IQ++++ Y ++K D + S S I GL+K T Y FRV A
Sbjct: 558 TWETPVSGNGEIQNYKLYY--MEKGTD---KEQDVDVSSHSYTINGLKKYTEYSFRVVAY 612
Query: 685 NMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTP 744
N G P + V S + P A P + N +IM+ W + N
Sbjct: 613 NKHG---PGVSTPDVAVRTLS----DVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQ 665
Query: 745 IHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNV 804
I G+ I YR + SD + +V G + I L T Y+ ++ G ++
Sbjct: 666 ITGYKIRYR--KASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDW 723
Query: 805 MICET 809
+ ET
Sbjct: 724 LSAET 728
Score = 108 bits (270), Expect = 3e-23
Identities = 185/864 (21%), Positives = 315/864 (36%), Gaps = 201/864 (23%)
Query: 35 VPQVTVQPASTVQKPGGTVILGCVVEPPRMN-VTWRLNGKELNGSDDALGVLITHGTLVI 93
+P+ T QP + G IL C V + V W N + L D + + G LVI
Sbjct: 151 LPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRV--IKLPSGMLVI 208
Query: 94 TALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDE--------GNT 145
+ G Y+CV +G V L L D ++ + ++ + + G
Sbjct: 209 SNATEGDGGLYRCVVE--SGGPPKYSDEVELKVLPDPEV-ISDLVFLKQPSPLVRVIGQD 265
Query: 146 AVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIM-PSGNLQIVNASQEDEGMYKCAAYN 204
V+ C + P +++ +E L+ L++ G+L+I + +++D G Y C A N
Sbjct: 266 VVLPC-VASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADN 324
Query: 205 PVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTW 264
++ + + A+ + + I + ++ EC +G P P V W
Sbjct: 325 ----------GNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKW 374
Query: 265 AKDGSSVTGYNKTRFLLS-NLLIDTTSEEDSGTYRCMADNGVG--QPGAAVILYN---VQ 318
K+G V + + + NL + + D G Y+C+A+N VG Q GA +I+
Sbjct: 375 VKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPAT 434
Query: 319 VFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPP------SVLWLRNAVPLISSQRLRLS 372
P ++ ++ + KLT + P SV + + I+ +R+ +
Sbjct: 435 TGPLPSAPRDVVASLVST-RFIKLTWRTPASDPHGDNLTYSVFYTKEG---IARERVENT 490
Query: 373 RRA----LRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTP 428
+ + ++ P +++ MA+N+ GS + LR
Sbjct: 491 SHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVET------------------ 532
Query: 429 PVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDS 488
PE L G P P ASP S
Sbjct: 533 --------QPEVQLPG----PAPNLRAYAASPT--------------------------S 554
Query: 489 YELVWRPRHEGSGRAPI--LYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYE 546
+ W G+G LYY+ K T+ D +S H T+ L + Y
Sbjct: 555 ITVTWETPVSGNGEIQNYKLYYM---EKGTDKEQDVDVSS-----HSYTINGLKKYTEYS 606
Query: 547 VEMAAYNCAGEG-QTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSP 605
+ AYN G G T V RT D P A+PQ+ S
Sbjct: 607 FRVVAYNKHGPGVSTPDVAVRT----------------LSDVPSAAPQNLS--------- 641
Query: 606 PEAPDRPTISTASETSVYVTWIPRG----NGGFPIQSFRVEYKKLKKVGDWILATSAIPP 661
+ + S+ + W P NG I +++ Y+K + D + + +
Sbjct: 642 --------LEVRNSKSIMIHWQPPAPATQNG--QITGYKIRYRKASRKSD--VTETLVSG 689
Query: 662 SRLSVEITGLEKGTSYKFRVRALNMLG-------------ESEPSAPSRPYVVSGYSGRV 708
++LS I GL++GT Y FRV AL + G ES+ P V S +
Sbjct: 690 TQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSS----L 745
Query: 709 YERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYY---RPTDSDNDSDYKK 765
+ RP+ T+I++ W P N N + G+ I Y P DYK
Sbjct: 746 HVRPLV------------TSIVVSW--TPPENQNIVVRGYAIGYGIGSPHAQTIKVDYK- 790
Query: 766 DMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPT 825
+ +++I +L P + Y I ++ FN GE + + E+ + +
Sbjct: 791 ------QRYYTIENLDPSSHYVITLKAFNNVGE----GIPLYESAVTRPHTDTSEVDLFV 840
Query: 826 LAPPQPPLPE--TIERPVGTGAMV 847
+ P P+P+ + PVG A +
Sbjct: 841 INAPYTPVPDPTPMMPPVGVQASI 864
Score = 66.6 bits (161), Expect = 1e-10
Identities = 91/374 (24%), Positives = 139/374 (37%), Gaps = 47/374 (12%)
Query: 531 QHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGA 590
Q T+ LDP S Y + + A+N GEG + +P S+ + P
Sbjct: 791 QRYYTIENLDPSSHYVITLKAFNNVGEG----IPLYESAVTRPHTDTSEVDLFVINAP-- 844
Query: 591 SPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTW----IPRGNGGFPIQSFRVEYKKL 646
+ PD + PP S S ++ +TW +P+ + + V +K
Sbjct: 845 ---YTPVPDPTPMMPPVGVQA---SILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTN 898
Query: 647 KKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSG 706
+A + LS +TGL+ T Y+F V S S + G
Sbjct: 899 IPANTKYKNANA---TTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAH--------G 947
Query: 707 RVYERPVAGPYITFTDAVNE---TTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDY 763
+E P T E TI++ W P S N I G+ IYY + D+
Sbjct: 948 TTFELVPTSPPKDVTVVSKEGKPKTIIVNWQ--PPSEANGKITGYIIYYSTDVNAEIHDW 1005
Query: 764 KKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICET------------KA 811
+ V G++ H I L +T Y K+Q N G S + T +A
Sbjct: 1006 VIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQA 1065
Query: 812 RKSSGQPGRLPPPTLAPPQPPLPETIERPVGTGAMVARSSDLPYLIVGVVLGSIVLIIVT 871
S G+ RL P L P P G+ S+ L +IV V + +IV++++
Sbjct: 1066 SGSGGKGSRL--PDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVII 1123
Query: 872 FIPFCLWRAWSKQK 885
+ FC R S QK
Sbjct: 1124 AV-FCTRRTTSHQK 1136
>gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
Length = 814
Score = 178 bits (452), Expect = 2e-44
Identities = 175/613 (28%), Positives = 267/613 (43%), Gaps = 87/613 (14%)
Query: 14 PEVTLACLLLATAGCFADLNEVPQVT--VQPASTVQKPGGTVILGCVVE-PPRMNVTWRL 70
P + L LLL L ++ V+P+ V PG ++L C VE P + +TWR
Sbjct: 18 PRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRK 77
Query: 71 NGKELNGSDDALGVLITHGTLVITAL------NNHTVGRYQCVARMPAGAVASVPATVTL 124
NG EL S + L+ +G+L+I + G Y+CVA+ G V S A +
Sbjct: 78 NGVELPESTHS--TLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQA 135
Query: 125 ANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGN 184
A + DF + Q + +EG A C + PK + + + ++ Y ++P G
Sbjct: 136 ATMSDFHVHPQATVG-EEGGVARFQCQI-HGLPKPLITWEKNRVPIDTDNERYTLLPKGV 193
Query: 185 LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAAR---IIYPPEAQTII 241
LQI ED G++ C A N + + RL V S + A + I+ PE T+
Sbjct: 194 LQITGLRAEDGGIFHCVASNIASIRISHGA---RLTVSGSGSGAYKEPAILVGPENLTLT 250
Query: 242 VTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFL-LSNLLIDTTSEEDSGTYRCM 300
V Q+ +LECVA+G P P V+W++ G + L NL+I + + SG Y C
Sbjct: 251 VH--QTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCA 308
Query: 301 ADNGVGQPGAAV---ILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWL 357
A+ +PG V + V P E + P G +A TC+ +G PPP V WL
Sbjct: 309 AN----RPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWL 364
Query: 358 RNAVPLISSQRLRLSRR--ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRT----SRP 411
+N L +RL L + +GPEDE +YQC+AEN GS+ A +L P
Sbjct: 365 KNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLP 424
Query: 412 SITPRLWQDAELATGTPPVSPSK-LGNPEQM---------------LRGQPALPR----- 450
PR + +++ VS S+ L N +++ L Q A+ +
Sbjct: 425 G-PPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQH 483
Query: 451 ------PPTSV----------GPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWR 494
P T+ G +S P A AP L S R + S +L+W
Sbjct: 484 LVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPL-SVRVLGSSSLQLLWE 542
Query: 495 P-----RHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEM 549
P +HEG + L+Y R + +S I +P L++LDP ++YEV++
Sbjct: 543 PWPRLAQHEGGFK---LFY----RPASKTSFTGPIL-LPGTVSSYNLSQLDPTAVYEVKL 594
Query: 550 AAYNCAGEGQTAM 562
AYN G+G +
Sbjct: 595 LAYNQHGDGNATV 607
Score = 41.6 bits (96), Expect = 0.004
Identities = 45/218 (20%), Positives = 84/218 (38%), Gaps = 17/218 (7%)
Query: 606 PEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLS 665
P P + S T V V+W I + + +K + + A+ S
Sbjct: 424 PGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPE-LEYQEAVSKSTFQ 482
Query: 666 VEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVN 725
++ LE T+Y F ++A G S S P+ + + E P P +
Sbjct: 483 HLVSDLEPSTAYSFYIKAYTPRGASSASVPT-------LASTLGEAPAPPPLSV--RVLG 533
Query: 726 ETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETS 785
+++ L W P + GF ++YRP + + ++ G +++S L P
Sbjct: 534 SSSLQLLWEPWPRLAQHEG--GFKLFYRPASKTSFTG--PILLPGTVSSYNLSQLDPTAV 589
Query: 786 YDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPP 823
Y++K+ +N+ G+ N + R +S + PP
Sbjct: 590 YEVKLLAYNQHGD---GNATVRFVSLRGASERTALSPP 624
Score = 34.3 bits (77), Expect = 0.68
Identities = 47/220 (21%), Positives = 79/220 (35%), Gaps = 36/220 (16%)
Query: 606 PEAPDRPTISTA-------SETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSA 658
P++ RP +TA E +VTW+ G P R+ K + L S
Sbjct: 336 PQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRL------KNNNSTLTISG 389
Query: 659 IPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYI 718
I P ++ ++ A N G S+ SA G G P
Sbjct: 390 IGPEDEAI------------YQCVAENSAGSSQASARLTVLWAEGLPGP--------PRN 429
Query: 719 TFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSIS 778
+V+ T + + W A N I G+ ++ R + +Y+ + V + H +S
Sbjct: 430 VRAVSVSSTEVRVSWSEPLA--NTKEIIGYVLHIRKAADPPELEYQ-EAVSKSTFQHLVS 486
Query: 779 HLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQP 818
L+P T+Y ++ + G S S + T + P
Sbjct: 487 DLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPP 526
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 178 bits (451), Expect = 3e-44
Identities = 193/846 (22%), Positives = 323/846 (38%), Gaps = 102/846 (12%)
Query: 21 LLLATAGCFADLNEVPQVTVQPASTVQKPGGT----VILGCVVEP-PRMNVTWRLNGKEL 75
L L+ C ++ + V VQ + P + V L C V P + W NG E+
Sbjct: 9 LFLSVTMCLSESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEI 68
Query: 76 NGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQ 135
+ D LI ++ G YQC+A G++ S AT+ A L +F +
Sbjct: 69 DLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTR 128
Query: 136 HVIEVDEGNTAVIACHLPESHPKAQVRYSVKQ--EWLEASRGNYLIMPSGNLQIVNASQE 193
+ V EG V+ C P P+ + + ++ ++ +GNL I
Sbjct: 129 SAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTS 188
Query: 194 DEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQ-----TIIVTKGQSL 248
D G Y C N VT + L +R Y P+ + T+ KG ++
Sbjct: 189 DVGSYICLVKNTVTN-ARVLSPPTPLTLRNDGVMGE---YEPKIEVHFPFTVTAAKGTTV 244
Query: 249 ILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQP 308
+EC A G P P +TW K + + R + L I +D+G Y C A+N G+
Sbjct: 245 KMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKN 304
Query: 309 GAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQR 368
+QV+ P +L+ + G + C+ G P P+ WL+N VPL R
Sbjct: 305 S---FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSR 361
Query: 369 LRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLR--TSRPSI-------TPRLWQ 419
+ + L + ++ D G+YQC+AEN+ G+ +A +L+ S P+ T + +
Sbjct: 362 VEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTK 421
Query: 420 DAEL-------ATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGE---KGQG 469
D E+ + P +S K + + LP + AS G+ +G+
Sbjct: 422 DQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGEN 481
Query: 470 APAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPA 529
A II +S + EL + G + +L H + + WT+ G P
Sbjct: 482 VFGSAEII-ASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPI 540
Query: 530 NQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPG 589
+ + G +E A + A ++ GR G
Sbjct: 541 DFE-------EEGGHFESIRAQASSADLMIRNILLMHAGRY------------------G 575
Query: 590 ASPQSS--SQPDHGRL---SPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYK 644
Q++ S D L PP P + +E++ ++W P + PI S+ ++ +
Sbjct: 576 CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQAR 635
Query: 645 KLKKVGDWILAT--SAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSR----- 697
+G + T I S L Y+FRV A N +G +PS PSR
Sbjct: 636 SPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTN 695
Query: 698 -------PYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYI 750
P VSG SGR +E +++ W + N G+ +
Sbjct: 696 EAVPKTAPTNVSGRSGRRHE------------------LVIAWEPVSEEFQNGEGFGYIV 737
Query: 751 YYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSN-VMICET 809
+RP + + E K+ + + P T +++K+ +N G+ FS V+IC
Sbjct: 738 AFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSA 797
Query: 810 KARKSS 815
+ S+
Sbjct: 798 EGEPSA 803
Score = 101 bits (251), Expect = 5e-21
Identities = 147/682 (21%), Positives = 241/682 (35%), Gaps = 119/682 (17%)
Query: 180 MPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQT 239
M +G L I N +Q D GMY+C A N + +S L++ A A +T
Sbjct: 364 MVNGVLMIHNVNQSDAGMYQCLAEN----KYGAIYASAELKI---LASAPTFALNQLKKT 416
Query: 240 IIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLL--SNLLIDTTSEEDSGTY 297
IIVTK Q +++EC G P P ++W K G NK +L +L I S+ D G Y
Sbjct: 417 IIVTKDQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGSLRILNASKSDEGKY 475
Query: 298 RCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVL-- 355
C +N G +A I+ ++ V EP + + + + G+S L C+ + V
Sbjct: 476 VCRGENVFG---SAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFY 532
Query: 356 WLRNAVPL--------ISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLR 407
W P+ S R + S L + ++ G Y C + S +L
Sbjct: 533 WTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELL 592
Query: 408 TSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVG----------- 456
P P + E+ T +S S + + R P S+G
Sbjct: 593 VRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEII 652
Query: 457 --------------------------------PASPQCPGEKGQGAPAEAPIILSSPRTS 484
P++P + P AP +S R+
Sbjct: 653 TGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSG-RSG 711
Query: 485 KTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTR---LDP 541
+ + W P E Y+V R N + W + +++ + R + P
Sbjct: 712 RRHELVIAWEPVSEEFQNGEGFGYIVAFRP--NGTRGWKEKMVTSSEASKFIYRDESVPP 769
Query: 542 GSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHG 601
+ +EV++ YN G+G + + ++ S E +
Sbjct: 770 LTPFEVKVGVYNNKGDGPFSQIV----------VICSAEGE------------------- 800
Query: 602 RLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPP 661
P AP ++ S + + V W Q F V Y K + D T
Sbjct: 801 ---PSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQED-TAETVKTRG 856
Query: 662 SRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFT 721
+ V +TGLE T Y F VRA N G PS S S + P +
Sbjct: 857 NESFVILTGLEGNTLYHFTVRAYNGAGYGPPS--------SEVSATTKKSPPSQAPSNLR 908
Query: 722 DAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQ 781
+ + L W + N + + G+ ++YR N ++E K ++ L
Sbjct: 909 WEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSN-----SQVIETQKL-QAVVPLP 962
Query: 782 PETSYDIKMQCFNEGGESEFSN 803
Y I+++ ++EGG+ S+
Sbjct: 963 DAGVYIIEVRAYSEGGDGTASS 984
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 176 bits (445), Expect = 1e-43
Identities = 186/810 (22%), Positives = 310/810 (38%), Gaps = 98/810 (12%)
Query: 53 VILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMP 111
V L C V P + W NG E++ D LI ++ G YQC+A
Sbjct: 119 VALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNT 178
Query: 112 AGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQ--EW 169
G++ S AT+ A L +F + + V EG V+ C P P+ + + +
Sbjct: 179 VGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSF 238
Query: 170 LEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAA 229
+ ++ +GNL I D G Y C N VT + L +R
Sbjct: 239 VAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTN-ARVLSPPTPLTLRNDGVMGE 297
Query: 230 RIIYPPEAQ-----TIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNL 284
Y P+ + T+ KG ++ +EC A G P P +TW K + + R + L
Sbjct: 298 ---YEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVL 354
Query: 285 LIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTC 344
I +D+G Y C A+N G+ +QV+ P +L+ + G + C
Sbjct: 355 EIPNVQLDDAGIYECRAENSRGKNS---FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWEC 411
Query: 345 EVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVV 404
+ G P P+ WL+N VPL R+ + L + ++ D G+YQC+AEN+ G+ +A
Sbjct: 412 KATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASA 471
Query: 405 QLR--TSRPSI-------TPRLWQDAEL-------ATGTPPVSPSKLGNPEQMLRGQPAL 448
+L+ S P+ T + +D E+ + P +S K + + L
Sbjct: 472 ELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAIL 531
Query: 449 PRPPTSVGPASPQCPGE---KGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPI 505
P + AS G+ +G+ A II +S + EL + G + +
Sbjct: 532 PDGSLRILNASKSDEGKYVCRGENVFGSAEII-ASLSVKEPTRIELTPKRTELTVGESIV 590
Query: 506 LYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTF 565
L H + + WT+ G P + + G +E A + A ++
Sbjct: 591 LNCKAIHDASLDVTFYWTLKGQPIDFE-------EEGGHFESIRAQASSADLMIRNILLM 643
Query: 566 RTGRRPKPEIMASKEQQIQRDDPGASPQSS--SQPDHGRL---SPPEAPDRPTISTASET 620
GR G Q++ S D L PP P + +E+
Sbjct: 644 HAGRY------------------GCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITES 685
Query: 621 SVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILAT--SAIPPSRLSVEITGLEKGTSYK 678
+ ++W P + PI S+ ++ + +G + T I S L Y+
Sbjct: 686 TATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYE 745
Query: 679 FRVRALNMLGESEPSAPSR------------PYVVSGYSGRVYERPVAGPYITFTDAVNE 726
FRV A N +G +PS PSR P VSG SGR +E
Sbjct: 746 FRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHE---------------- 789
Query: 727 TTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSY 786
+++ W + N G+ + +RP + + E K+ + + P T +
Sbjct: 790 --LVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPF 847
Query: 787 DIKMQCFNEGGESEFSN-VMICETKARKSS 815
++K+ +N G+ FS V+IC + S+
Sbjct: 848 EVKVGVYNNKGDGPFSQIVVICSAEGEPSA 877
Score = 101 bits (251), Expect = 5e-21
Identities = 147/682 (21%), Positives = 241/682 (35%), Gaps = 119/682 (17%)
Query: 180 MPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQT 239
M +G L I N +Q D GMY+C A N + +S L++ A A +T
Sbjct: 438 MVNGVLMIHNVNQSDAGMYQCLAEN----KYGAIYASAELKI---LASAPTFALNQLKKT 490
Query: 240 IIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLL--SNLLIDTTSEEDSGTY 297
IIVTK Q +++EC G P P ++W K G NK +L +L I S+ D G Y
Sbjct: 491 IIVTKDQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGSLRILNASKSDEGKY 549
Query: 298 RCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVL-- 355
C +N G +A I+ ++ V EP + + + + G+S L C+ + V
Sbjct: 550 VCRGENVFG---SAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFY 606
Query: 356 WLRNAVPL--------ISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLR 407
W P+ S R + S L + ++ G Y C + S +L
Sbjct: 607 WTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELL 666
Query: 408 TSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVG----------- 456
P P + E+ T +S S + + R P S+G
Sbjct: 667 VRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEII 726
Query: 457 --------------------------------PASPQCPGEKGQGAPAEAPIILSSPRTS 484
P++P + P AP +S R+
Sbjct: 727 TGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSG-RSG 785
Query: 485 KTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTR---LDP 541
+ + W P E Y+V R N + W + +++ + R + P
Sbjct: 786 RRHELVIAWEPVSEEFQNGEGFGYIVAFRP--NGTRGWKEKMVTSSEASKFIYRDESVPP 843
Query: 542 GSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHG 601
+ +EV++ YN G+G + + ++ S E +
Sbjct: 844 LTPFEVKVGVYNNKGDGPFSQIV----------VICSAEGE------------------- 874
Query: 602 RLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPP 661
P AP ++ S + + V W Q F V Y K + D T
Sbjct: 875 ---PSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQED-TAETVKTRG 930
Query: 662 SRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFT 721
+ V +TGLE T Y F VRA N G PS S S + P +
Sbjct: 931 NESFVILTGLEGNTLYHFTVRAYNGAGYGPPS--------SEVSATTKKSPPSQAPSNLR 982
Query: 722 DAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQ 781
+ + L W + N + + G+ ++YR N ++E K ++ L
Sbjct: 983 WEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSN-----SQVIETQKL-QAVVPLP 1036
Query: 782 PETSYDIKMQCFNEGGESEFSN 803
Y I+++ ++EGG+ S+
Sbjct: 1037 DAGVYIIEVRAYSEGGDGTASS 1058
Score = 43.5 bits (101), Expect = 0.001
Identities = 47/192 (24%), Positives = 78/192 (40%), Gaps = 37/192 (19%)
Query: 231 IIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLL--SNLLIDT 288
II+P ++ + + L C G P P W ++G+ + + R+ L +I
Sbjct: 108 IIFPTDSDE------KKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISN 161
Query: 289 TSE-EDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMEL-----------SQLVIPW 336
SE +DSG Y+C+A N VG IL E T++ S + +
Sbjct: 162 PSEAKDSGHYQCLATNTVGS-----ILSR-------EATLQFAYLGNFSGRTRSAVSVRE 209
Query: 337 GQSAKLTCEVRGNPPPSVL-WLRNAVP--LISSQRLRLSRRA--LRVLSMGPEDEGVYQC 391
GQ L C + P + W+ N P + R +S+ L + + D G Y C
Sbjct: 210 GQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYIC 269
Query: 392 MAENEVGSAHAV 403
+ +N V +A +
Sbjct: 270 LVKNTVTNARVL 281
>gi|83281200 protogenin [Homo sapiens]
Length = 1150
Score = 163 bits (413), Expect = 7e-40
Identities = 211/865 (24%), Positives = 338/865 (39%), Gaps = 113/865 (13%)
Query: 11 GMRPEVTLACLLLAT---AGCFADLNEVPQVTVQPASTVQKPGGTVILGCVV--EPPRMN 65
GM L LLL+ CF++L+ V + P V+L C E P +
Sbjct: 15 GMLLRALLLLLLLSPLPGVWCFSELSFVKE----PQDVTVTRKDPVVLDCQAHGEVP-IK 69
Query: 66 VTWRLNGKELNGSDDALGVLITHGTLVITALNNHT-----VGRYQCVARMPAGAVASVPA 120
VTW NG ++ S++ ++++G+L I+ + G YQC+A GA+ S A
Sbjct: 70 VTWLKNGAKM--SENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKA 127
Query: 121 TVTLANLQDFKLDVQHV-IEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLI 179
+ L+ + F +VQ + EV EG A AC + SHP A + + + L +
Sbjct: 128 HLALSTISAF--EVQPISTEVHEGGVARFACKI-SSHPPAVITWEFNRTTLPMTMDRITA 184
Query: 180 MPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTA-EAARIIYPPEAQ 238
+P+G LQI + SQ D G Y+C A + S + + S + II P Q
Sbjct: 185 LPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGP--Q 242
Query: 239 TIIVTKGQSLILECVASGIPPPRVTWAK-DGSSVTGYNKTRFLLSNLLIDTTSEEDSGTY 297
I + Q+++LEC+A+G P P ++W++ D S+ +N NL+I + +G Y
Sbjct: 243 NITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAGVY 302
Query: 298 RCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWL 357
C A G V + + V PP L P +A+ C+ G P P + WL
Sbjct: 303 VCRATTP-GTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWL 361
Query: 358 RNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGS----AHAVVQLRTSRPSI 413
+N + S+ R+++ L + + PED+ +YQCMAEN GS A V + RPS
Sbjct: 362 KNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSA 421
Query: 414 -------------------TPRLWQDAELATGTPPVSPSKLGNPE-QMLRG--------- 444
P D +A + L N E Q++ G
Sbjct: 422 PYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIID 481
Query: 445 --QPA-------LPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRP 495
+PA + P S + P P I + R S TD + W P
Sbjct: 482 DLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSR-SPTDIL-ISWLP 539
Query: 496 RHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCA 555
R ++ Y + R T +S + +P H L L P S+Y V + A
Sbjct: 540 IPAKYRRGQVVLYRLSFRLSTENSIQ--VLELPGTTHEYLLEGLKPDSVYLVRITAATRV 597
Query: 556 GEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTIS 615
G G++++ T + R PK + + + SP+ +P
Sbjct: 598 GLGESSVWT--SHRTPKATSVKAPK----------SPELHLEP----------------- 628
Query: 616 TASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGT 675
+ T++ V W IQ +++ Y K+ G + L ++GL+
Sbjct: 629 -LNCTTISVRWQQDVEDTAAIQGYKLYY---KEEGQQENGPIFLDTKDLLYTLSGLDPRR 684
Query: 676 SYKFRVRALNML--GESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKW 733
Y R+ A N + G S P VS V P P+ + A ++I L W
Sbjct: 685 KYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMV--PPPPPPHHLYAKANTSSSIFLHW 742
Query: 734 MYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCF 793
PA I + I P N S ++ + + L+P T Y+ ++
Sbjct: 743 RR-PAF-TAAQIINYTIRCNPVGLQNASLVL--YLQTSETHMLVQGLEPNTKYEFAVRLH 798
Query: 794 NEGGESEFSNVMICETKARKSSGQP 818
+ S +S V+ T +G P
Sbjct: 799 VDQLSSPWSPVVYHSTLPEAPAGPP 823
Score = 69.3 bits (168), Expect = 2e-11
Identities = 150/766 (19%), Positives = 265/766 (34%), Gaps = 131/766 (17%)
Query: 138 IEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYL-IMPSGNLQIVNAS----- 191
+ V + V+ C ++H + ++ + + + S + ++ +G+L I
Sbjct: 48 VTVTRKDPVVLDC---QAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGE 104
Query: 192 QEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILE 251
Q DEG Y+C A N + S + + ST A + + + V +G
Sbjct: 105 QSDEGFYQCLAMNKYGAIL-----SQKAHLALSTISAFEV----QPISTEVHEGGVARFA 155
Query: 252 CVASGIPPPRVTWAKDGSSV--TGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPG 309
C S PP +TW + +++ T T L I S+ DSG YRC+A +
Sbjct: 156 CKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRK 215
Query: 310 AAVILYNV------QVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPL 363
+ V + F P + + Q+ L C GNP P + W R
Sbjct: 216 SMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKS 275
Query: 364 ISSQRLR-LSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAE 422
I R L L + + + GVY C A G+ + V + T P + E
Sbjct: 276 IDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTP-GTRNFTVAMATLTVLAPPSFVEWPE 334
Query: 423 LAT--------------GTPPVSPSKLGNPEQM-LRGQPALPRPPTSVGPASP------Q 461
T G P S L N ++ G+ + + P Q
Sbjct: 335 SLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQ 394
Query: 462 CPGEKGQGA---PAEAPIILSSPR----------TSKTDSYELVW-RPRHEGSGRAPILY 507
C E QG+ A +++S R T + + L W RP + ++
Sbjct: 395 CMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSD---KVIA 451
Query: 508 YVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRT 567
Y V + K +++ I + + L+P S Y + AY G Q +
Sbjct: 452 YSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMS------ 505
Query: 568 GRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWI 627
Q D P L PPE ++++ S T + ++W+
Sbjct: 506 ---------DHVTQNTLEDVP--------------LRPPEI----SLTSRSPTDILISWL 538
Query: 628 P------RGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRV 681
P RG SFR+ + +V + +P + + GL+ + Y R+
Sbjct: 539 PIPAKYRRGQVVLYRLSFRLSTENSIQVLE-------LPGTTHEYLLEGLKPDSVYLVRI 591
Query: 682 RALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNN 741
A +G E S + S + + P + +N TTI ++W +
Sbjct: 592 TAATRVGLGESSVWTSHRTPKATSVKAPKSPE-----LHLEPLNCTTISVRWQ--QDVED 644
Query: 742 NTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEF 801
I G+ +YY+ + D + +++S L P Y +++ +N +
Sbjct: 645 TAAIQGYKLYYKEEGQQENGPIFLDTKD---LLYTLSGLDPRRKYHVRLLAYNNIDDG-- 699
Query: 802 SNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIERPVGTGAMV 847
+A ++ PG + P PP P + T + +
Sbjct: 700 -------YQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSI 738
Score = 48.9 bits (115), Expect = 3e-05
Identities = 61/290 (21%), Positives = 108/290 (37%), Gaps = 39/290 (13%)
Query: 535 TLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQS 594
TL+ LDP Y V + AYN +G A T T P ++ +++ +
Sbjct: 676 TLSGLDPRRKYHVRLLAYNNIDDGYQADQTVST-----PGCVSVRDRMV----------- 719
Query: 595 SSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWIL 654
PP P + +S+++ W I ++ + + ++
Sbjct: 720 ---------PPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLV 770
Query: 655 ATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVA 714
+ S + + GLE T Y+F VR L + S+P P V Y + E P
Sbjct: 771 L--YLQTSETHMLVQGLEPNTKYEFAVR----LHVDQLSSPWSPVV---YHSTLPEAPAG 821
Query: 715 GPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYW 774
P + + T ++ W P T + + I Y + +++ EG
Sbjct: 822 PPVGVKVTLIEDDTALVSWK--PPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITM 879
Query: 775 HSISHLQPETSYDIKMQCFNEGGESEFSN---VMICETKARKSSGQPGRL 821
+ +L Y +K+ NE GE FSN + + + +S+ +P RL
Sbjct: 880 ALLENLVAGNVYIVKISASNEVGEGPFSNSVELAVLPKETSESNQRPKRL 929
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 148 bits (374), Expect = 2e-35
Identities = 102/365 (27%), Positives = 161/365 (44%), Gaps = 22/365 (6%)
Query: 53 VILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMP 111
V+L C P W++NG E+ + L+ +++ G YQC+A P
Sbjct: 57 VLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNP 116
Query: 112 AGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQ--EW 169
G V S A + LQ+F + + ++ EG ++ C+ P +P R+ + + +
Sbjct: 117 VGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNF 176
Query: 170 LEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAA 229
+ +++ +GNL I + D G Y C A + + + T + AE
Sbjct: 177 IPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHM--DFSTKSVFSKFAQLNLAAEDT 234
Query: 230 RII-------YPPEAQTIIVTKGQSLILECVASGIPPPRVTWAK-DGSSVTGYNKTRFLL 281
R+ +P E ++ GQ + LEC A G P PR+ W K DGS +
Sbjct: 235 RLFAPSIKARFPAETYALV---GQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAE--- 288
Query: 282 SNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAK 341
L I + S ED GTY C A+N G+ + + V PE +S G + +
Sbjct: 289 PTLQIPSVSFEDEGTYECEAENSKGRD---TVQGRIIVQAQPEWLKVISDTEADIGSNLR 345
Query: 342 LTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAH 401
C G P P+V WLRN PL S R+ + LR + ED G+YQC+AEN+ G+ +
Sbjct: 346 WGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIY 405
Query: 402 AVVQL 406
A +L
Sbjct: 406 ASAEL 410
Score = 93.2 bits (230), Expect = 1e-18
Identities = 171/744 (22%), Positives = 275/744 (36%), Gaps = 172/744 (23%)
Query: 50 GGTVILGCVVE-PPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVA 108
G + GC PR V W NG+ L S + + VL G L + L+ G YQCVA
Sbjct: 341 GSNLRWGCAAAGKPRPTVRWLRNGEPL-ASQNRVEVLA--GDLRFSKLSLEDSGMYQCVA 397
Query: 109 RMPAGAVASVPATVTLANLQDFKLD-VQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQ 167
G + + A DF+L+ V+ +I G +I C P + PKA V +S
Sbjct: 398 ENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ-PRAAPKAVVLWSKGT 456
Query: 168 EWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAE 227
E L S + P G L I N S+ DEG Y C A N + + + S+ L VR +
Sbjct: 457 EILVNS-SRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGK----ANSTGILSVR----D 507
Query: 228 AARIIYPPEAQTIIVTKGQSLILECVASGIPPPRV--TWAKDGSSVT------GYNKT-- 277
A +I P + I G +L L+C AS P + TW D + Y +T
Sbjct: 508 ATKITLAPSSADI--NLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNV 565
Query: 278 RFLLSNLLIDTTSEEDSGTYRCMADNGV---------------GQPGAAVILYNVQVFEP 322
+ + +L I G Y CMA V G PG V V +
Sbjct: 566 KETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVV------VRDI 619
Query: 323 PEVTMELSQLVIPWGQS-------AKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRA 375
+ T++LS W + AK T + R PP+ W + + + +
Sbjct: 620 GDTTIQLS-----WSRGFDNHSPIAKYTLQAR--TPPAGKWKQVRT---NPANIEGNAET 669
Query: 376 LRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKL 435
+VL + P + ++ +A N +G TG P
Sbjct: 670 AQVLGLTPWMDYEFRVIASNILG--------------------------TGEP------- 696
Query: 436 GNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRP 495
P +R + A P SV P+ G GAP E +I++ W P
Sbjct: 697 SGPSSKIRTREAAP----SVAPSGL----SGGGGAPGE--LIVN-------------WTP 733
Query: 496 RHEGSGRAPILYYVVKHRKVTNSSDDWTISGIP---ANQHRLTLTRLDPGSLYEVEMAAY 552
Y++ R+ S W + +P A + + P + +EV++ +Y
Sbjct: 734 MSREYQNGDGFGYLLSFRR--QGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSY 791
Query: 553 NCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRP 612
N G+G ++ ++ S E++ P AP +
Sbjct: 792 NRRGDGPESLTA----------LVYSAEEE----------------------PRVAPTKV 819
Query: 613 TISTASETSVYVTWIP-RGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRL--SVEIT 669
S + + VTW P + + + + + Y K GD A + + L S ++
Sbjct: 820 WAKGVSSSEMNVTWEPVQQDMNGILLGYEIRY---WKAGDKEAAADRVRTAGLDTSARVS 876
Query: 670 GLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTI 729
GL T Y VRA N G + P++PS + + P P + + +++
Sbjct: 877 GLHPNTKYHVTVRAYNRAG-TGPASPSA-------NATTMKPPPRRPPGNISWTFSSSSL 928
Query: 730 MLKWMYIPASNNNTPIHGFYIYYR 753
+KW + N + + G+ + Y+
Sbjct: 929 SIKWDPVVPFRNESAVTGYKMLYQ 952
Score = 48.1 bits (113), Expect = 5e-05
Identities = 40/197 (20%), Positives = 82/197 (41%), Gaps = 10/197 (5%)
Query: 605 PPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSA---IPP 661
PP P + +T++ ++W + PI + ++ + G W + I
Sbjct: 607 PPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQ-ARTPPAGKWKQVRTNPANIEG 665
Query: 662 SRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFT 721
+ + ++ GL Y+FRV A N+LG EPS PS + V ++G
Sbjct: 666 NAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGG----G 721
Query: 722 DAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQ 781
A E +++ W + N G+ + +R S + + + + +S ++
Sbjct: 722 GAPGE--LIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVR 779
Query: 782 PETSYDIKMQCFNEGGE 798
P T +++K++ +N G+
Sbjct: 780 PYTPFEVKIRSYNRRGD 796
Score = 38.5 bits (88), Expect = 0.036
Identities = 46/182 (25%), Positives = 76/182 (41%), Gaps = 29/182 (15%)
Query: 231 IIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLL--SNLLI-D 287
+++P E+ + ++L C A PP W +G+ + +R L NL+I +
Sbjct: 46 VLFPEESTE------EQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMN 99
Query: 288 TTSEEDSGTYRCMADNGVGQ--PGAAVILYN-VQVFEPPEVTMELSQLVIPWGQSAKLTC 344
T +D+G Y+C+A N VG A++ + +Q F E + G L C
Sbjct: 100 PTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKE----ERDPVKAHEGWGVMLPC 155
Query: 345 EVRGNPPP-----SVLWLRNAVP--LISSQRLRLSRRA--LRVLSMGPEDEGVYQCMAEN 395
NPP S WL N P + + R +S+ L + D G Y C+A +
Sbjct: 156 ----NPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATS 211
Query: 396 EV 397
+
Sbjct: 212 HM 213
Score = 31.2 bits (69), Expect = 5.7
Identities = 29/155 (18%), Positives = 54/155 (34%), Gaps = 20/155 (12%)
Query: 675 TSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWM 734
T ++ ++R+ N G+ S + Y E P P + V+ + + + W
Sbjct: 782 TPFEVKIRSYNRRGDGPESLTALVYSAE-------EEPRVAPTKVWAKGVSSSEMNVTWE 834
Query: 735 YIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFN 794
+ N + Y++ D + +D + G +S L P T Y + ++ +N
Sbjct: 835 PVQQDMNGILLGYEIRYWKAGDKEAAADRVR--TAGLDTSARVSGLHPNTKYHVTVRAYN 892
Query: 795 EGGESEFSNVMICETKARKSSGQPGRLPPPTLAPP 829
G T S + PP PP
Sbjct: 893 RAG-----------TGPASPSANATTMKPPPRRPP 916
>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4
[Homo sapiens]
Length = 1250
Score = 147 bits (372), Expect = 4e-35
Identities = 219/943 (23%), Positives = 344/943 (36%), Gaps = 168/943 (17%)
Query: 1 MLRGTMTAWRGMRPEVTLACLLLATAGCFADLNEVPQVT-------VQPASTVQKPGGTV 53
M RG RG+ + L LLA G +PQ T V P + P
Sbjct: 1 MARGDAGRGRGL---LALTFCLLAARGELL----LPQETTVELSCGVGPLQVILGPEQAA 53
Query: 54 ILGC----VVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITAL-----NNHTV--- 101
+L C P VTW +G L D L+ +G+L ++ ++ +V
Sbjct: 54 VLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLH--LLPNGSLWLSQPLAPNGSDESVPEA 111
Query: 102 -----GRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESH 156
G Y C+A P G +AS A V LA L DF L + V+E TA CH+ E
Sbjct: 112 VGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQT-VEENGTARFECHI-EGL 169
Query: 157 PKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGS- 215
P + + Q L +++P+G LQI++ + D G Y+C A N Q
Sbjct: 170 PAPIITWEKDQVTLP-EEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALL 228
Query: 216 --SDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTG 273
+ R + + + I+ PE T++ GQS+++ECVAS P P V+W +
Sbjct: 229 SVAHRGSLASTRGQDVVIVAAPENTTVV--SGQSVVMECVASADPTPFVSWVRQDGKPIS 286
Query: 274 YNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLV 333
+ +NLLI SG Y C A N A ++V P +T L
Sbjct: 287 TDVIVLGRTNLLIANAQPWHSGVYVCRA-NKPRTRDFATAAAELRVLAAPAITQAPEALS 345
Query: 334 IPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL--SRRALRVLSMGPEDEGVYQC 391
+A+ C G P P++ WL N PL + R+++ +L + +G +D G YQC
Sbjct: 346 RTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQC 405
Query: 392 MAENEVGSAHAVVQL----RTSRPSITPRL-------------WQDAEL----------- 423
+AEN G A A L R PS R+ W+ E+
Sbjct: 406 VAENSAGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLH 465
Query: 424 ---ATGTPPVS-PSKLGNPEQMLRGQPALPRPP--------TSVGPASPQCPG--EKGQG 469
A G V + N L+ + P + +G + P
Sbjct: 466 YQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDD 525
Query: 470 APAEAP-IILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIP 528
P+ AP + LSSP S + W P ++ Y +++ D + +
Sbjct: 526 VPSAAPQLSLSSPNPS---DIRVAWLPLPPSLSNGQVVKYKIEYG--LGKEDQIFSTEVR 580
Query: 529 ANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDP 588
N+ +L L L P +Y V ++A AG G + Q + P
Sbjct: 581 GNETQLMLNSLQPNKVYRVRISAGTAAGFG-------------------APSQWMHHRTP 621
Query: 589 GASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKL-- 646
H + P AP + E S+ V+W P + I +++ ++++
Sbjct: 622 SM---------HNQSHVPFAPAELKVQAKME-SLVVSWQPPPH-PTQISGYKLYWREVGA 670
Query: 647 --KKVGD----------WILATSAIPPSRLSVEITGLEKGTSYKFRVRALN--------- 685
+ GD W + + E+T L G Y+ ++ A N
Sbjct: 671 EEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAV 730
Query: 686 MLGESEPS-APSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTP 744
G++E + AP P + P P ++ + T+I L+W
Sbjct: 731 WKGKTEKAPAPDMP---------IQRGPPLPPAHVHAESNSSTSIWLRWK--KPDFTTVK 779
Query: 745 IHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNV 804
I + + + P N S G+ I L+P T Y+ +Q + F +V
Sbjct: 780 IVNYTVRFSPWGLRNASLVTYYTSSGEDI--LIGGLKPFTKYEFAVQSHGVDMDGPFGSV 837
Query: 805 MICETKARKSSGQPG--RLPPPT-------LAPPQPPLPETIE 838
+ T + S P RL P T PP P E +E
Sbjct: 838 VERSTLPDRPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVE 880
Score = 97.4 bits (241), Expect = 6e-20
Identities = 192/886 (21%), Positives = 336/886 (37%), Gaps = 158/886 (17%)
Query: 22 LLATAGCFADLNEVPQVTVQPASTVQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGSDD 80
+LA+ L + ++ P S + GT C +E P +TW + L ++
Sbjct: 129 VLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQVTL--PEE 186
Query: 81 ALGVLITHGTLVITALNNHTVGRYQCVARMPAG------AVASVPATVTLANLQDFKLDV 134
+++ +G L I + G Y+CVA A A+ SV +LA+ + + +
Sbjct: 187 PRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVI 246
Query: 135 QHVIE---VDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNAS 191
E V G + V+ C + + P V + V+Q+ S + +++ NL I NA
Sbjct: 247 VAAPENTTVVSGQSVVMEC-VASADPTPFVSW-VRQDGKPIST-DVIVLGRTNLLIANAQ 303
Query: 192 QEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILE 251
G+Y C A P T++ T+ + LRV + A I PEA + T+ +
Sbjct: 304 PWHSGVYVCRANKPRTRDFATAAAE--LRVLAAPA----ITQAPEA--LSRTRASTARFV 355
Query: 252 CVASGIPPPRVTWAKDGSSV--TGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPG 309
C ASG P P + W +G+ + G K + +L+I +D+G Y+C+A+N G
Sbjct: 356 CRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMAC 415
Query: 310 AA----VILYNVQVFEPPEVT---MELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVP 362
AA V++ P VT + S +++ W + + ++ G L + A
Sbjct: 416 AAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFS----LHYQKARG 471
Query: 363 LISSQ---RLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAH----AVVQLRTSRPSITP 415
+ + + + L+V + P + + +A +++G++ A+V PS P
Sbjct: 472 MDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAP 531
Query: 416 RLW----QDAELATGTPPVSPSK-------------LGNPEQM----LRG---------- 444
+L +++ P+ PS LG +Q+ +RG
Sbjct: 532 QLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSL 591
Query: 445 QP-ALPRPPTSVGPAS----------------------PQCPGEKGQGAPAEAPIIL--S 479
QP + R S G A+ P P E A E+ ++
Sbjct: 592 QPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKMESLVVSWQP 651
Query: 480 SPRTSKTDSYELVWRP---RHEGSG-RAPILYYVVKHRKVTNSSDDWTISGIPANQH--R 533
P ++ Y+L WR E +G R P W + + + +
Sbjct: 652 PPHPTQISGYKLYWREVGAEEEANGDRLP----------GGRGDQAWDVGPVRLKKKVKQ 701
Query: 534 LTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQ 593
LT+L PG LYEV++ A+N +G A+ +T + P P++ IQR
Sbjct: 702 YELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDM------PIQR-------- 747
Query: 594 SSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWI 653
PP P + S TS+++ W I ++ V + W
Sbjct: 748 ----------GPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRF------SPWG 791
Query: 654 LATSAI----PPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVY 709
L +++ S + I GL+ T Y+F V +S P+ +
Sbjct: 792 LRNASLVTYYTSSGEDILIGGLKPFTKYEFAV-------QSHGVDMDGPFGSVVERSTLP 844
Query: 710 ERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVE 769
+RP P + +T+ L W P + N I + I Y + + + +
Sbjct: 845 DRPSTPPSDLRLSPLTPSTVRLHW--CPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQ 902
Query: 770 GDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSS 815
G+ + + L+ +T Y KM E G FS + T K S
Sbjct: 903 GNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLS 948
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 145 bits (366), Expect = 2e-34
Identities = 171/727 (23%), Positives = 262/727 (36%), Gaps = 119/727 (16%)
Query: 140 VDEGNTAVIACHLPESHPKAQVRYSVKQEWL----EASRGNYLIMPSGNL---QIVNA-- 190
V G A + C E P+ + + + E R + L++PSG L +IV+
Sbjct: 75 VSRGEPATLPCRA-EGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRR 133
Query: 191 SQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLIL 250
++ DEG+Y C A N + + S + +R ++ ++V G+ +L
Sbjct: 134 ARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPG--------NVVVAVGEPAVL 185
Query: 251 ECVAS-GIPPPRVTWAKDGSSVTGYN-KTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQP 308
ECV G P P V+W KDG+ + + L++ T + D+G Y C+A N G+
Sbjct: 186 ECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGER 245
Query: 309 GAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQR 368
+A V V E P V+ CEV+G+PPP + W + L + +
Sbjct: 246 ESAAA--EVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRY 303
Query: 369 LRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTP 428
S +L + + EDEG Y C+AEN VG A A L P QD A G
Sbjct: 304 EIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGES 363
Query: 429 PVSPSKL-GNPEQML----RGQPALPRPPTSVGPASPQCPGEKGQ--------------- 468
+ GNP + G L P S+ P +GQ
Sbjct: 364 VAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYV 423
Query: 469 -------------------GAPAEA--PIILSSPRTSKTDSYELVWRPRHEGSGRAPILY 507
GA + P+IL P VW P P
Sbjct: 424 CQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQP--- 480
Query: 508 YVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLY-----EVEMAAYNCAGEGQTAM 562
S W G L + G+LY E++M Y+C + T
Sbjct: 481 -----------SVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGE 529
Query: 563 VTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSV 622
T+ + R+D G SP ++P SPP AP +P ++ ++ S+
Sbjct: 530 ATWSGWLK-------------MREDWGVSPDPPTEPS----SPPGAPSQPVVTEITKNSI 572
Query: 623 YVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVR 682
+TW P G + S+ +E W + +V +GL+ T Y F VR
Sbjct: 573 TLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTV--SGLQPNTIYLFLVR 630
Query: 683 ALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPY------------ITFTDAVNETTIM 730
A+ G SEPS S P S RPV P+ + + T+
Sbjct: 631 AVGAWGLSEPSPVSEPVRTQDSSP---SRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQ 687
Query: 731 LKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKM 790
+ W + GF + +R + S D+ + + L P T IK+
Sbjct: 688 VSW---TVDGPVQLVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKV 744
Query: 791 QCFNEGG 797
Q + G
Sbjct: 745 QAQGQEG 751
Score = 120 bits (300), Expect = 9e-27
Identities = 173/706 (24%), Positives = 263/706 (37%), Gaps = 113/706 (16%)
Query: 10 RGMRP-EVTLACLLLATAGCFADLNEVPQVTVQPASTVQKPGGTVI-------LGCVVEP 61
R RP E C+ G A N +V V Q PG V+ L CV P
Sbjct: 132 RRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECV--P 189
Query: 62 PR----MNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVAS 117
PR +V+WR +G L + + I G L+++ G Y CVA AG S
Sbjct: 190 PRGHPEPSVSWRKDGARLKEEEGR--ITIRGGKLMMSHTLKSDAGMYVCVASNMAGERES 247
Query: 118 VPATVTLANLQDF-KLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGN 176
A V + F + V V+ D T + C + + P ++R+ ++E E G
Sbjct: 248 AAAEVMVLERPSFLRRPVNQVVLADAPVTFL--CEV-KGDPPPRLRW--RKEDGELPTGR 302
Query: 177 YLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPE 236
Y I +L I + S EDEG Y C A N V + + SGS S +++ P+
Sbjct: 303 YEIRSDHSLWIGHVSAEDEGTYTCVAENSVGR-AEASGSL-------SVHVPPQLVTQPQ 354
Query: 237 AQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKT------RFLLS---NLLID 287
Q + G+S+ +C G PPP + W K+GS V + RF +S L I
Sbjct: 355 DQ--MAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNIT 412
Query: 288 TTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFE---PPEVTMELSQLVIPWGQSAKLTC 344
D+G Y C A + G A +L PP + + + G S L C
Sbjct: 413 AVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPC 472
Query: 345 EVRGNPPPSVLWLRNAVPLISS--QRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHA 402
V GNP PSV W ++ L Q ++ L + ++ D G Y C+A++ G A
Sbjct: 473 RVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEA-- 530
Query: 403 VVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQC 462
T W +M P PPT P+SP
Sbjct: 531 -----------TWSGWL--------------------KMREDWGVSPDPPTE--PSSP-- 555
Query: 463 PGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDW 522
GAP++ P++ + S T L W+P + +G A Y + ++
Sbjct: 556 -----PGAPSQ-PVVTEITKNSIT----LTWKPNPQ-TGAAVTSYVIEAFSPAAGNTWRT 604
Query: 523 TISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQ 582
G+ H T++ L P ++Y + A G + P P S+ +
Sbjct: 605 VADGVQLETH--TVSGLQPNTIYLFLVRAVGAWGLSE-----------PSP---VSEPVR 648
Query: 583 IQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVE 642
Q P + + G P + ++ V+W G +Q FRV
Sbjct: 649 TQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIV--LGPRTLQVSWTVDGPVQL-VQGFRVS 705
Query: 643 YKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLG 688
++ G PS+ S + GL GT + +V+A G
Sbjct: 706 WRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEG 751
Score = 65.5 bits (158), Expect = 3e-10
Identities = 62/226 (27%), Positives = 94/226 (41%), Gaps = 21/226 (9%)
Query: 234 PPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKT----RFLLSN------ 283
PP+ ++V++G+ L C A G P P + W K+G+ V + R LL +
Sbjct: 70 PPD---LLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFP 126
Query: 284 -LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKL 342
++ + D G Y C+A N +G + V V + +V+ G+ A L
Sbjct: 127 RIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLR-DDFRQSPGNVVVAVGEPAVL 185
Query: 343 TC-EVRGNPPPSVLWLRNAVPLISSQ-RLRLSRRALRVLSMGPEDEGVYQCMAENEVG-- 398
C RG+P PSV W ++ L + R+ + L + D G+Y C+A N G
Sbjct: 186 ECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGER 245
Query: 399 -SAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLR 443
SA A V + RPS R LA G+P LR
Sbjct: 246 ESAAAEVMV-LERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLR 290
Score = 43.5 bits (101), Expect = 0.001
Identities = 27/89 (30%), Positives = 43/89 (48%), Gaps = 11/89 (12%)
Query: 323 PEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLIS------SQRLRLSRRAL 376
P + + L++ G+ A L C G P P++ W +N + + + RL L AL
Sbjct: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
Query: 377 ---RVL--SMGPEDEGVYQCMAENEVGSA 400
R++ DEGVY C+A N +G+A
Sbjct: 124 FFPRIVHGRRARPDEGVYTCVARNYLGAA 152
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 144 bits (362), Expect = 6e-34
Identities = 189/807 (23%), Positives = 317/807 (39%), Gaps = 91/807 (11%)
Query: 36 PQVTVQPAST-VQKPGGTVILGCVVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVIT 94
P +P T V G ++L C+ E +W L K L+ + + + + +IT
Sbjct: 26 PYFKTEPVRTQVHLEGNRLVLTCMAEG-----SWPLEFKWLHNNRELTKFSLEY-RYMIT 79
Query: 95 ALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPE 154
+L+ G Y+C+ R GA+ V +A + F+ +H V G AVI
Sbjct: 80 SLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQ-SVSHGEAAVIRAPRIA 138
Query: 155 SHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSG 214
S P+ QV + + S I L I++ D G Y A N + KTS
Sbjct: 139 SFPQPQVTWFRDGRKIPPS-SRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTS- 196
Query: 215 SSDRLRVRR----STAEAARIIYPPEAQTIIVTKGQSLILECVASGIP--PPRVTWAKDG 268
L V + A II PP+ T +V + LECVA+ P + W KDG
Sbjct: 197 QPITLTVENVGGPADPIAPTIIIPPK-NTSVVAGTSEVTLECVANARPLIKLHIIWKKDG 255
Query: 269 SSVTG----YNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPE 324
++G +N+ L I + D+G Y C A + V + V EPP+
Sbjct: 256 VLLSGGISDHNR------RLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQ 309
Query: 325 VTMELSQ-LVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRR---ALRVLS 380
E + + + + C+ +G PPPS+ W ++A + + R +R L++
Sbjct: 310 FVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISG 369
Query: 381 MGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQ 440
+ P+D G++QC A N G L + SI P + + P+ + +
Sbjct: 370 LVPDDTGMFQCFARNAAGEVQTSTYLAVT--SIAPNITRG--------PLDSTVIDGMSV 419
Query: 441 MLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGS 500
+L + + G P +KG+ A + L PR + +S L+ P H S
Sbjct: 420 VLACETS--------GAPRPAITWQKGERILASGSVQL--PRFTPLESGSLLISPTHI-S 468
Query: 501 GRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQT 560
R V +S D + + R+T D S+ + A+ C G
Sbjct: 469 DAGTYTCLATNSRGVDEASADLVVWA----RTRITKPPQDQ-SVIKGTQASMVC-GVTHD 522
Query: 561 AMVTFR---------TGRRPKPEIMASKE-----QQIQRDDPG-------ASPQSSSQPD 599
VT R G P I + Q D G ++ + S+
Sbjct: 523 PRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSA 582
Query: 600 HGRLSP-PEAPDRP--TISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILAT 656
H R+ P AP+ P T+ST ++ +TW +G P+ + +E + W +
Sbjct: 583 HLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMS--ENNAPWTVLL 640
Query: 657 SAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGP 716
+++ P SV + GL SY+FR+ A+N +G+ + S + + E P A P
Sbjct: 641 ASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLP------EEPPTAPP 694
Query: 717 YITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHS 776
+IM++W P S+ N + G+ I Y + K++ + D
Sbjct: 695 QNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQF-KNITDADVNNLL 753
Query: 777 ISHLQPETSYDIKMQCFNEGGESEFSN 803
+ L T+Y+I++ +N G +S+
Sbjct: 754 LEDLIIWTNYEIEVAAYNSAGLGVYSS 780
Score = 99.0 bits (245), Expect = 2e-20
Identities = 189/882 (21%), Positives = 327/882 (37%), Gaps = 156/882 (17%)
Query: 1 MLRGTMTAWRGMRPEVTLACLLLATAGCFADLNEVPQVTVQPASTVQKPGGTVILGCVVE 60
++R M A + EV +A + G F + + V+ A+ ++ P +
Sbjct: 92 IVRNRMGALLQRQTEVQVAYM-----GSFEEGEKHQSVSHGEAAVIRAPR-------IAS 139
Query: 61 PPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRY--QCVARMPAGAVASV 118
P+ VTW +G+++ S + TLVI + GRY Q V S
Sbjct: 140 FPQPQVTWFRDGRKIPPSSRI--AITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQ 197
Query: 119 PATVTLANLQDFKLDVQHVIEVDEGNTAVIA--------CHLPESHPKAQVRYSVKQEWL 170
P T+T+ N+ + I + NT+V+A C + + P ++ K++ +
Sbjct: 198 PITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLEC-VANARPLIKLHIIWKKDGV 256
Query: 171 EASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLR-VRRSTAEAA 229
S G + + L I N + D G Y+C A +++S +R S E
Sbjct: 257 LLSGG--ISDHNRRLTIPNPTGSDAGYYECEAV------LRSSSVPSVVRGAYLSVLEPP 308
Query: 230 RIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN---LLI 286
+ + PE I + + + C A G+PPP +TW KD + V TRF N L I
Sbjct: 309 QFVKEPERH-ITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQI 367
Query: 287 DTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEV 346
+D+G ++C A N G+ + L + P +T + G S L CE
Sbjct: 368 SGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSI--APNITRGPLDSTVIDGMSVVLACET 425
Query: 347 RGNPPPSVLWLRNAVPLISSQRLRLSR------RALRVLSMGPEDEGVYQCMAENEVG-- 398
G P P++ W + +++S ++L R +L + D G Y C+A N G
Sbjct: 426 SGAPRPAITW-QKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVD 484
Query: 399 --SAHAVVQLRTSRPSITPRLWQDAELATGT-----------PPVSPSKLGNPEQMLRGQ 445
SA VV RT R + P QD + GT P V+ + + G
Sbjct: 485 EASADLVVWART-RITKPP---QDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGT 540
Query: 446 PALPR------------------------PPTSVGPASPQCPGEKGQGAPAEAPIILSSP 481
+ PR S G + + + P +++
Sbjct: 541 ESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATL 600
Query: 482 RTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTI--SGIPANQHRLTLTRL 539
T + + L W +G+ +P++ Y++ +++ ++ WT+ + + +T+ L
Sbjct: 601 STVERRAINLTWTKPFDGN--SPLIRYIL---EMSENNAPWTVLLASVDPKATSVTVKGL 655
Query: 540 DPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPD 599
P Y+ + A N G+GQ + T R S P+
Sbjct: 656 VPARSYQFRLCAVNDVGKGQFSKDTERV----------------------------SLPE 687
Query: 600 HGRLSPPEAPDRPTISTA-SETSVYVTW--IPRGNGGFPIQSFRVEYKKL-KKVGDWILA 655
PP AP + I++ + S+ + W P + ++ + + Y VG
Sbjct: 688 ----EPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKN 743
Query: 656 TSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAG 715
+ + L +E L T+Y+ V A N G S+ + + G P
Sbjct: 744 ITDADVNNLLLE--DLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGV-------PTVP 794
Query: 716 PYITFTDAVNETTIMLKWMYIPASNNNTP--IHGFYIYYRPTDSDNDSDYKKDMVEGDKY 773
P +A N TTI W N +P I+G Y+ + + + + MV
Sbjct: 795 PGNVHAEATNSTTIRFTW------NAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPN 848
Query: 774 WHS------ISHLQPETSYDIKMQCFNEGGESEFSNVMICET 809
+ +S L+ T Y + CF G+ S + T
Sbjct: 849 FQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRT 890
Score = 79.7 bits (195), Expect = 1e-14
Identities = 85/371 (22%), Positives = 147/371 (39%), Gaps = 77/371 (20%)
Query: 467 GQGAPAEAPII------LSSPRTS------KTDSYELVWRPRHEGSGRAPILYYVVKHRK 514
G G+P+ PI+ + P +T S L+W+P +G IL Y + HR
Sbjct: 1283 GDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI--ILAYQITHRL 1340
Query: 515 VTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTA---MVTFRTGRRP 571
T +++ T+ + + + T T L P S+Y + A G G+ A +VT RP
Sbjct: 1341 NTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRP 1400
Query: 572 KPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGN 631
+P +Q++D A SV ++W P +
Sbjct: 1401 QPP----SRPMVQQEDVRAR-----------------------------SVLLSWEPGSD 1427
Query: 632 GGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESE 691
G P++ + ++ ++L G W L ++++ + S + L+ TSYKFRV+A N +G+SE
Sbjct: 1428 GLSPVRYYTIQTRELPS-GRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSE 1486
Query: 692 PSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIY 751
S S + P P I T+++++W N + GF I
Sbjct: 1487 FSEESESLTT------LQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIR 1540
Query: 752 YR-------------------PTDSDNDSDYK-KDMVEGDKYWHSISHLQPETSYDIKMQ 791
YR T ++ S Y +++ + + +L Y+I+M
Sbjct: 1541 YRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMS 1600
Query: 792 CFNEGGESEFS 802
+N GE S
Sbjct: 1601 VYNAVGEGPSS 1611
Score = 76.6 bits (187), Expect = 1e-13
Identities = 78/294 (26%), Positives = 119/294 (40%), Gaps = 56/294 (19%)
Query: 536 LTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSS 595
+T L + Y +E+AA G+GQ + T +G
Sbjct: 955 VTGLTALTTYTIEVAAMTSKGQGQVSASTISSG--------------------------- 987
Query: 596 SQPDHGRLSPPEAPDRPT---ISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGD- 651
PPE P PT IS SV + + P +G I + VE ++ VG+
Sbjct: 988 --------VPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVE-AQVGVVGEG 1038
Query: 652 --WILATS-AIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRV 708
W+L + P S+E+ L T Y FR+R +N++G S PS PSR +
Sbjct: 1039 EEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQT------L 1092
Query: 709 YERPVAGPYITFTDAVNETTIMLKWMYIPAS--NNNTPIHGFYIYYRPTDSDND--SDYK 764
P P +ET++ L+WM +P N N G+ I Y +D S
Sbjct: 1093 QAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVV 1152
Query: 765 KDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQP 818
+D VE D ++I L+ T Y +++Q FN G +S ++ T+ S P
Sbjct: 1153 QDRVERD---YTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGP 1203
Score = 67.4 bits (163), Expect = 7e-11
Identities = 165/741 (22%), Positives = 257/741 (34%), Gaps = 131/741 (17%)
Query: 27 GCFADLNEVPQVTVQPASTVQKPGGTVI-LGCVVEP-PRMNVTWRLNGKELNGSDDALGV 84
G + + E PQ +P + V+ + C + P ++TW + +
Sbjct: 299 GAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFR 358
Query: 85 LITHGTLVITALNNHTVGRYQCVARMPAG--------AVASVPATVTLANLQDFKLDVQH 136
G L I+ L G +QC AR AG AV S+ +T L +D
Sbjct: 359 QRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVID--- 415
Query: 137 VIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRG----NYLIMPSGNLQIVNASQ 192
G + V+AC + P+ + + K E + AS + + SG+L I
Sbjct: 416 ------GMSVVLACETSGA-PRPAITWQ-KGERILASGSVQLPRFTPLESGSLLISPTHI 467
Query: 193 EDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILEC 252
D G Y C A N S D RI PP+ Q++I KG + C
Sbjct: 468 SDAGTYTCLATN--------SRGVDEASADLVVWARTRITKPPQDQSVI--KGTQASMVC 517
Query: 253 VASGIPPPRVT----WAKDGSSVTGYNKTRFLLS---NLLIDTTSEEDSGTYRCMADNGV 305
+ PRVT W KDG+++ + R L +L I T D GTY C +
Sbjct: 518 GVTH--DPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG 575
Query: 306 GQPGAAVILYNVQVFEPPE------VTMELSQLVIPW-----GQSA--KLTCEVRGNPPP 352
G + L Q+ PE T+E + + W G S + E+ N P
Sbjct: 576 GNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAP 635
Query: 353 SVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQL-RTSRP 411
+ L + P +S + V + P ++ A N+VG R S P
Sbjct: 636 WTVLLASVDPKATS---------VTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLP 686
Query: 412 SITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKG---Q 468
P +A+G N M++ QP P S Q KG +
Sbjct: 687 EEPPTAPPQNVIASGRT--------NQSIMIQWQPP---------PESHQNGILKGYIIR 729
Query: 469 GAPAEAPIILSSPRTSKTDSYEL------VWRPRHEGSGRAPILYYVVKHRKVTNSSDDW 522
A P+ + D L +W V KVT +W
Sbjct: 730 YCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVT----EW 785
Query: 523 TISGIPA----NQH---------RLTLTRLDPGSLYEV----EMAAYNCAGEGQTAMVTF 565
T+ G+P N H R T P + + ++ A+ E + MVT
Sbjct: 786 TLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTA 845
Query: 566 R------------TGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPT 613
R +G + E S + PG P+S+ Q P +
Sbjct: 846 RPNFQDSIHVGFVSGLKKFTEYFTSV---LCFTTPGDGPRSTPQLVRTHEDVPGPVGHLS 902
Query: 614 ISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEK 673
S +TS+ V+W G + +R+ +++ + + T +P L +TGL
Sbjct: 903 FSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRV--THYLPNVTLEYRVTGLTA 960
Query: 674 GTSYKFRVRALNMLGESEPSA 694
T+Y V A+ G+ + SA
Sbjct: 961 LTTYTIEVAAMTSKGQGQVSA 981
Score = 66.6 bits (161), Expect = 1e-10
Identities = 63/240 (26%), Positives = 112/240 (46%), Gaps = 23/240 (9%)
Query: 589 GASPQSS-SQPDHGRLSPPE-APDRPTISTASETSVYVTWIP----RGNGGFPIQSFRVE 642
G SP S S+ +PP+ AP ++ TASETS+++ W+P NG ++++
Sbjct: 1078 GTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIK 1137
Query: 643 YKKLKKVGDWILATSAIPPSRLSVEIT--GLEKGTSYKFRVRALNMLGESEPSAPSRPYV 700
Y + G + S + R+ + T LE+ T Y+ +V+A N +G S P V
Sbjct: 1138 YSRSDGHGKTL---SHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG----SGPWSQTV 1190
Query: 701 VSGYSGRVYER-PVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDN 759
V GR E P +GP A ++++++W +P ++ N + G+ + Y+ DSD
Sbjct: 1191 V----GRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDT 1246
Query: 760 DSDYKKDMVEGDKYWHS-ISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQP 818
+ +VEG+ + ++ L Y++++ F G+ S+ I E G P
Sbjct: 1247 QPRFW--LVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPP 1304
Score = 57.0 bits (136), Expect = 1e-07
Identities = 78/349 (22%), Positives = 137/349 (39%), Gaps = 46/349 (13%)
Query: 456 GPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKV 515
GP S G + P+ P +S+ T+ + S + W E +L Y V +++
Sbjct: 1184 GPWSQTVVGRTRESVPSSGPTNVSALATTSS-SMLVRWSEVPEADRNGLVLGYKVMYKEK 1242
Query: 516 TNSSDD--WTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKP 573
+ + W + G + +LT L LYEV++ A+ G+G + P
Sbjct: 1243 DSDTQPRFWLVEGNSSRSAQLT--GLGKYVLYEVQVLAFTRIGDGSPS----------HP 1290
Query: 574 EIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNGG 633
I+ ++ D PG PP P + T TSV + W P
Sbjct: 1291 PIL----ERTLDDVPG---------------PPMGILFPEVRT---TSVRLIWQPPAAPN 1328
Query: 634 FPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPS 693
I ++++ ++ L + PS TGL+ + Y FR+ A G E +
Sbjct: 1329 GIILAYQITHR-LNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAA 1387
Query: 694 APSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYR 753
+V R +P + P + D V +++L W P S+ +P+ + I R
Sbjct: 1388 EA----LVVTTEKRDRPQPPSRPMVQQED-VRARSVLLSWE--PGSDGLSPVRYYTIQTR 1440
Query: 754 PTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFS 802
S + + + + + L+P TSY +++ N+ G+SEFS
Sbjct: 1441 ELPSGRWALHSASVSHNASSF-IVDRLKPFTSYKFRVKATNDIGDSEFS 1488
Score = 56.2 bits (134), Expect = 2e-07
Identities = 78/361 (21%), Positives = 129/361 (35%), Gaps = 80/361 (22%)
Query: 456 GPASPQCPGEKGQGAPAEAP--IILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHR 513
GP+SP G+ P AP +++ ++ D + W P S I Y +
Sbjct: 1608 GPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLD---VTWEPPPLDSQNGDIQGYKIYFW 1664
Query: 514 KVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKP 573
+ + + + ++ + L L + Y V +AA+N AG+G
Sbjct: 1665 EAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDG--------------- 1709
Query: 574 EIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTW-IPRGNG 632
P+S+ + + P AP S + TSV V+W P+
Sbjct: 1710 ------------------PRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPN 1751
Query: 633 GFPIQSFRVEYKKLKKVG--DWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNML--- 687
G ++ +R+ Y+ V I+ S L +++ L +G +Y+FR+RA
Sbjct: 1752 GI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGP 1810
Query: 688 ----------GESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIP 737
GE P P P +V YS + I + W
Sbjct: 1811 EIEANVTTGPGEGAPGPPGVPIIVR-YS---------------------SAIAIHWS--S 1846
Query: 738 ASNNNTPIHGFYIYYRPTDSDNDSDYKKDMV-EGDKYWHSISHLQPETSYDIKMQCFNEG 796
PI + I RP+D KD+ E Y S+ L+P SYD ++ N+
Sbjct: 1847 GDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDY 1906
Query: 797 G 797
G
Sbjct: 1907 G 1907
Score = 53.9 bits (128), Expect = 8e-07
Identities = 83/363 (22%), Positives = 138/363 (38%), Gaps = 77/363 (21%)
Query: 468 QGAPAEAPIILS-SPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRK------------ 514
Q AP EAP ILS +P T T S + W+P E +L + +++R+
Sbjct: 1498 QAAPDEAPTILSVTPHT--TTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLR 1555
Query: 515 -VTNSSDDW---TISGIPANQHRLTLTRLDPGSL-----YEVEMAAYNCAGEGQTAMVTF 565
+ N W T N R +LT+ + +L YE+ M+ YN GEG ++
Sbjct: 1556 GINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSS---- 1611
Query: 566 RTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVT 625
P E+ G P AP + A+ T + VT
Sbjct: 1612 -----PPQEVFV-----------------------GEAVPTAAPRNVVVHGATATQLDVT 1643
Query: 626 WIP----RGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRV 681
W P NG IQ +++ + + ++ G+ + + SV++ L T+Y V
Sbjct: 1644 WEPPPLDSQNG--DIQGYKIYFWEAQR-GNLTERVKTLFLAENSVKLKNLTGYTAYMVSV 1700
Query: 682 RALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNN 741
A N G+ S P++ G+ + + P + T++ + W P N
Sbjct: 1701 AAFNAAGDGPRSTPTQ--------GQTQQAAPSAPSSVKFSELTTTSVNVSW-EAPQFPN 1751
Query: 742 NTPIHGFYIYYRP-TDSDNDSDYKKDMVEGDK-YWHSISHLQPETSY--DIKMQCFNEGG 797
+ G+ + Y P + D S V+G+ W + L +Y I+ + F G
Sbjct: 1752 GI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGP 1810
Query: 798 ESE 800
E E
Sbjct: 1811 EIE 1813
Score = 48.5 bits (114), Expect = 3e-05
Identities = 43/185 (23%), Positives = 80/185 (43%), Gaps = 16/185 (8%)
Query: 218 RLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYN-K 276
++R R+ + + +T + +G L+L C+A G P W + +T ++ +
Sbjct: 14 QIRAARAQDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLE 73
Query: 277 TRFLLSNLLIDTTSEEDSGTYRCMADNGVG---QPGAAVILYNVQVFEPPEVTMELSQLV 333
R+++++L +G YRC+ N +G Q V + + FE E +S
Sbjct: 74 YRYMITSL-----DRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSH-- 126
Query: 334 IPWGQSAKLTC-EVRGNPPPSVLWLRNAVPLISSQRLRLS-RRALRVLSMGPEDEGVYQC 391
G++A + + P P V W R+ + S R+ ++ L +LS D G Y
Sbjct: 127 ---GEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYV 183
Query: 392 MAENE 396
A N+
Sbjct: 184 QAVND 188
Score = 48.1 bits (113), Expect = 5e-05
Identities = 87/388 (22%), Positives = 145/388 (37%), Gaps = 81/388 (20%)
Query: 455 VGPASPQCPGEKGQG--APAEAPIILSSPRTSKTDSYELVWRP--RHEGSGRAPILYYVV 510
VG + P P K Q AP + S RT+ S L W P E +G + Y +
Sbjct: 1077 VGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKI 1136
Query: 511 KHRKVTNSSDDWTISGIPAN--QHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTG 568
K+ + + T+S + + + T+ L+ + Y V++ A+N G G
Sbjct: 1137 KYSR--SDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSG---------- 1184
Query: 569 RRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEA-PDRPTISTASETSVYVTW- 626
P S + R S P + P + + +S+ V W
Sbjct: 1185 -----------------------PWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWS 1221
Query: 627 -IPRGNGGFPIQSFRVEYKKLKKVGD-----WILATSAIPPSRLSVEITGLEKGTSYKFR 680
+P + + ++V YK+ K D W++ + S S ++TGL K Y+ +
Sbjct: 1222 EVPEADRNGLVLGYKVMYKE--KDSDTQPRFWLVEGN----SSRSAQLTGLGKYVLYEVQ 1275
Query: 681 VRALNMLGESEPSAPSRPYVVSGYSGRVYERP---VAGPY--ITFTDAVNETTIMLKWMY 735
V A +G+ PS P + ER V GP I F + V T++ L W
Sbjct: 1276 VLAFTRIGDGSPSHPP-----------ILERTLDDVPGPPMGILFPE-VRTTSVRLIWQP 1323
Query: 736 IPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVE---GDKYWHSISHLQPETSYDIKMQC 792
A N G + Y+ T N + VE ++ + L+PE+ Y ++
Sbjct: 1324 PAAPN------GIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITA 1377
Query: 793 FNEGGESEFSNVMICETKARKSSGQPGR 820
G E + ++ T+ R P R
Sbjct: 1378 QTRKGWGEAAEALVVTTEKRDRPQPPSR 1405
Score = 39.3 bits (90), Expect = 0.021
Identities = 31/112 (27%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 588 PGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLK 647
P ++ P G PP P I +++ + W G PI + +E +
Sbjct: 1810 PEIEANVTTGPGEGAPGPPGVP----IIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSD 1865
Query: 648 KVGDWILATSAIPP--SRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSR 697
+ G W + IP S + + L+ G SY FRV A+N G PS+PS+
Sbjct: 1866 E-GLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQ 1916
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 139 bits (349), Expect = 2e-32
Identities = 104/401 (25%), Positives = 177/401 (44%), Gaps = 21/401 (5%)
Query: 21 LLLATAGCFAD--LNEVPQVTVQPASTVQKPGGT---VILGCVVEP-PRMNVTWRLNGKE 74
+LL+ GC L + P +P++++ G + L C P + W+LNG +
Sbjct: 9 ILLSFIGCLGGELLLQGPVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNGSD 68
Query: 75 LNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDV 134
++ S + L +VI N G YQC A G + S A + A L++FK +
Sbjct: 69 IDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKM 128
Query: 135 QHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQ--EWLEASRGNYLIMPSGNLQIVNASQ 192
+ + V EG V+ C P + + + ++E ++ +G+L I
Sbjct: 129 RSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEP 188
Query: 193 EDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQ-----TIIVTKGQS 247
D G Y C + VT + GS L +R ++ Y P+ + T+ KG +
Sbjct: 189 SDVGNYTCVVTSMVTN-ARVLGSPTPLVLR---SDGVMGEYEPKIEVQFPETLPAAKGST 244
Query: 248 LILECVASGIPPPRVTWAK-DGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVG 306
+ LEC A G P P++ W + DG + K R L I +ED+G+Y C+A+N G
Sbjct: 245 VKLECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRG 304
Query: 307 QPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISS 366
+ V + + P + + I S C G P PS WL+N L+
Sbjct: 305 KN---VARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLE 361
Query: 367 QRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLR 407
+R ++ AL + ++ D G++QC+AEN+ G ++ +L+
Sbjct: 362 ERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELK 402
Score = 114 bits (285), Expect = 5e-25
Identities = 175/793 (22%), Positives = 301/793 (37%), Gaps = 121/793 (15%)
Query: 89 GTLVITALNNHTVGRYQCV-------ARMPAGAVASVPATVTLANLQDFKLDVQ--HVIE 139
G L I+ + VG Y CV AR+ V + + + K++VQ +
Sbjct: 179 GHLYISKVEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLP 238
Query: 140 VDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYK 199
+G+T + C +P Q+ + + + L S L SG L+I N QED G Y+
Sbjct: 239 AAKGSTVKLEC-FALGNPIPQINWR-RSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYE 296
Query: 200 CAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPP 259
C A N + V R A+ + + + + SL EC ASG P
Sbjct: 297 CIAENSRGKNV----------ARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPK 346
Query: 260 PRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQV 319
P W K+G+++ +T+ L I S DSG ++C+A+N G ++ L V
Sbjct: 347 PSYRWLKNGAALVLEERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAEL-KVVA 405
Query: 320 FEPPEVTMELSQLV-IPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL-SRRALR 377
P + +LV + G L C+ R +P W + V + +R+ L + L+
Sbjct: 406 SAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDGGLK 465
Query: 378 VLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGN 437
+ ++ D G Y CMAEN+ G A+ L + P+ + +++ G + P ++ +
Sbjct: 466 IANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQH 525
Query: 438 PEQM-------LRGQPALPRPPTS----VGPASP----------------QCPGEKGQGA 470
+ G A + S VG +S C + G +
Sbjct: 526 DPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDS 585
Query: 471 PAEAPIIL-----SSPRTSKTD-----SYELVWRPRHEG-SGRAPILYYVVKHRKVTNSS 519
+ A ++ P K D + +L W+ EG +P++ Y ++ R T S
Sbjct: 586 VSSAADLIVRGSPGPPENVKVDEITDTTAQLSWK---EGKDNHSPVISYSIQAR--TPFS 640
Query: 520 DDW-TISGIP----ANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPE 574
W T++ +P H T+ L+P YE + A N G G+ ++ P
Sbjct: 641 VGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSL----------PS 690
Query: 575 IMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIP-----R 629
E+ + P P S + + +TW P +
Sbjct: 691 EKVRTEEAV---------------------PEVPPSEVNGGGGSRSELVITWDPVPEELQ 729
Query: 630 GNGGFPIQSFRVEYKKLKKVGDWILATSAIPPS-RLSVEITGLEKGTSYKFRVRALNMLG 688
GF + V ++ L V WI P + R + + Y+ +V N G
Sbjct: 730 NGEGF---GYVVAFRPL-GVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKG 785
Query: 689 ESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGF 748
E P +P V + +S E P P ++++ + I + W IP +N + G+
Sbjct: 786 EG-PFSP----VTTVFSAE--EEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGY 838
Query: 749 YIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICE 808
+ Y +S K V G++ + L+ +Y ++ +N G FS +
Sbjct: 839 EVRYWNGGGKEESS-SKMKVAGNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVT 897
Query: 809 TKARKSSGQPGRL 821
TK S PG +
Sbjct: 898 TKKTPPSQPPGNV 910
Score = 95.9 bits (237), Expect = 2e-19
Identities = 157/736 (21%), Positives = 269/736 (36%), Gaps = 169/736 (22%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPAT 121
P+ + W NG L + I +G L I+ L+ G +QC+A G V S
Sbjct: 345 PKPSYRWLKNGAALVLEERTQ---IENGALTISNLSVTDSGMFQCIAENKHGLVYSSAEL 401
Query: 122 VTLANLQDF-KLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIM 180
+A+ DF K ++ +++V G+ + C P + P+A + K + ++
Sbjct: 402 KVVASAPDFSKNPMKKLVQVQVGSLVSLDCK-PRASPRALSSWK-KGDVSVQEHERISLL 459
Query: 181 PSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTI 240
G L+I N ++ D G Y C A N Q K +G++ + E RI P +
Sbjct: 460 NDGGLKIANVTKADAGTYTCMAEN---QFGKANGTTHLV-----VTEPTRITLAPSNMDV 511
Query: 241 IVTKGQSLILECVASGIPPPRV--TW---------AKDGS---SVTGYNKTRFLLSNLLI 286
V G+S+IL C P + TW KDGS V G + ++ N+ +
Sbjct: 512 SV--GESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQL 569
Query: 287 DTTSEEDSGTYRCMADNGVGQPGAAVILY---------NVQVFEPPEVTMELSQLVIPWG 337
+ SG Y CM GV +A L NV+V E + T +LS
Sbjct: 570 -----KHSGKYVCMVQTGVDSVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKDN 624
Query: 338 QSAKLTCEVRGNPPPSVLWLR-NAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENE 396
S ++ ++ P SV W VP + + + V+ + P E ++ +A N+
Sbjct: 625 HSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTHTA----TVVELNPWVEYEFRVVASNK 680
Query: 397 VGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVG 456
+G PS+ P + +R + A+P P
Sbjct: 681 IGG---------GEPSL------------------------PSEKVRTEEAVPEVP---- 703
Query: 457 PASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVT 516
P E G + + ++++ W P E YVV R +
Sbjct: 704 ------PSEVNGGGGSRSELVIT-------------WDPVPEELQNGEGFGYVVAFRPLG 744
Query: 517 NSSDDWTISGIP-ANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEI 575
++ T+ P ++ + P S YEV++ YN GEG + VT +
Sbjct: 745 VTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVT---------TV 795
Query: 576 MASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTW--IPRGNGG 633
+++E+ P AP + + ++ S + + V+W IP
Sbjct: 796 FSAEEE-----------------------PTVAPSQVSANSLSSSEIEVSWNTIPWKLSN 832
Query: 634 FPIQSFRVEY----------KKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRA 683
+ + V Y K+K G + S + GL+ +Y VRA
Sbjct: 833 GHLLGYEVRYWNGGGKEESSSKMKVAG-----------NETSARLRGLKSNLAYYTAVRA 881
Query: 684 LNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNT 743
N G SA + + P + P +T ++L W + A N +
Sbjct: 882 YNSAGAGPFSAT--------VNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAMENES 933
Query: 744 PIHGFYIYYRPTDSDN 759
+ G+ ++YR + +N
Sbjct: 934 EVTGYKVFYRTSSQNN 949
Score = 52.8 bits (125), Expect = 2e-06
Identities = 45/225 (20%), Positives = 87/225 (38%), Gaps = 10/225 (4%)
Query: 606 PEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSA---IPPS 662
P P+ + ++T+ ++W + P+ S+ ++ + VG W T+ I
Sbjct: 598 PGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVG-WQTVTTVPEVIDGK 656
Query: 663 RLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTD 722
+ + L Y+FRV A N +G EPS PS V V G
Sbjct: 657 THTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVNG------G 710
Query: 723 AVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQP 782
+ + +++ W +P N G+ + +RP + +Y + P
Sbjct: 711 GGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVP 770
Query: 783 ETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLA 827
+ Y++K+ +N GE FS V + + + P ++ +L+
Sbjct: 771 YSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLS 815
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 138 bits (347), Expect = 3e-32
Identities = 135/444 (30%), Positives = 190/444 (42%), Gaps = 58/444 (13%)
Query: 38 VTVQPASTVQKPGGTVILGCVVEP----------PRMNVTWRLNGKELNGSDDALGVLIT 87
+TVQ AS V KP +V+ E PR +TW+ G LN + ++
Sbjct: 2660 LTVQ-ASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG--LNVATGVSTQVLP 2716
Query: 88 HGTLVITALNNHTVGRYQCVARMPAGA-------VASVPATVTLANLQDFKLDVQHVIEV 140
G L I + G Y C+A+ AG+ V VP + L D +
Sbjct: 2717 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIE-NGLPD--------LST 2767
Query: 141 DEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKC 200
EG+ A + C S P+ + + + + + G + I PSG L + N +D G Y C
Sbjct: 2768 TEGSHAFLPCKARGS-PEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTC 2826
Query: 201 AAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPP 260
A N V + R RV + P +++ + G L L C A G P P
Sbjct: 2827 TAENAVGRA--------RRRVHLTILVLPVFTTLPGDRSLRL--GDRLWLRCAARGSPTP 2876
Query: 261 RVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVF 320
R+ W + VT + S L S EDSGTY C A+N VG+ A V V
Sbjct: 2877 RIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF---VHVK 2933
Query: 321 EPPEVTME-LSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQ-RLRLSRRALRV 378
E P + E S LV P G S +L C VRG+P P + W+++ +PL S R +L +L +
Sbjct: 2934 EAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTI 2993
Query: 379 LSMGPEDEGVYQCMAENEVGSAHAVVQL--------RTSRPSITPRLWQDAEL---ATG- 426
+D G YQC+AENE+G A VV L + +T R D L ATG
Sbjct: 2994 RRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGE 3053
Query: 427 -TPPVSPSKLGNPEQMLRGQPALP 449
TP + + G P + R LP
Sbjct: 3054 PTPTIEWLQAGQPLRASRRLRTLP 3077
Score = 110 bits (274), Expect = 1e-23
Identities = 118/460 (25%), Positives = 181/460 (39%), Gaps = 68/460 (14%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPAT 121
P V W + + + L V L IT + GRYQCVA PAG A
Sbjct: 154 PTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQA----- 208
Query: 122 VTLANLQDFKLDVQHVIEV----DEGNTAVIACHLPE------SHPKAQVRYSVKQEWLE 171
+DF+L V + + G AV+ HL + P + + L
Sbjct: 209 ------RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLP 262
Query: 172 ASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARI 231
S LQ+ A D G+Y C A N V G++++ A +
Sbjct: 263 TSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAV-------GAAEK-------ATRLDV 308
Query: 232 IYPPEAQ-------TIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLL--S 282
PP + + G+ + LECVA G P P ++W +G V N++R S
Sbjct: 309 YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGS 368
Query: 283 NLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPE--VTMELSQLVIPWGQSA 340
L +++ E SG Y C+A + G+ AV+ Y+V+V PP+ V L Q+ GQ
Sbjct: 369 VLRLESPGEASSGLYSCVASSPAGE---AVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPL 425
Query: 341 KLTCEVRGNPPPSVLWLRNAVPL--ISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVG 398
+L C+ G+P P++ WL+N P ++ ++ L + + + G++ C A NE G
Sbjct: 426 ELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 485
Query: 399 SAHAVVQLRTSRPSITPRLWQDAELAT-------GTPPVSPSKLGNPEQMLRGQPALPRP 451
+A A V++ W L G S + RG A P+P
Sbjct: 486 TAGAEVEVSVHGE------WAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKP 539
Query: 452 PTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYEL 491
P G SP G P P+ S P + + +L
Sbjct: 540 PLVEGWCSP----GSLWGEPTGIPVAYSLPPPLQIEKVDL 575
Score = 110 bits (274), Expect = 1e-23
Identities = 114/387 (29%), Positives = 156/387 (40%), Gaps = 35/387 (9%)
Query: 42 PASTVQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGT-LVITALNNH 99
P V G ++L C VE P +TW +G L +DA G L + AL+
Sbjct: 2306 PRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQ--EDAHTQFPERGRFLQLQALSTA 2363
Query: 100 TVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKA 159
G Y C AR AG+ SV V + + + + V TA++ C + P
Sbjct: 2364 DSGDYSCTARNAAGST-SVAFRVEIHTVPTIRSGPP-AVNVSVNQTALLPCQA-DGVPAP 2420
Query: 160 QVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDR- 218
V + + L+ + I+P G+L+I +D G Y C A N S SDR
Sbjct: 2421 LVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASN--------SAGSDRQ 2472
Query: 219 ---LRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVT--- 272
LRV A A P + +T +L C ASG P P V W KDG +
Sbjct: 2473 GRDLRVLEPPAIA------PSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL 2526
Query: 273 GYNKTRFLLSN-LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQ 331
R L SN LL+ +DS + C+ N VG+ A LY V V PP + + +
Sbjct: 2527 QQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGE---AHRLYQVTVHVPPTIADDQTD 2583
Query: 332 LVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPL-ISSQRLRLSRR-ALRVLSMGPEDEGVY 389
+ LTC G P P+V W + L R+S AL + P G Y
Sbjct: 2584 FTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRY 2643
Query: 390 QCMAENEVGSAHAVVQLRT-SRPSITP 415
C A N G AH V L + P + P
Sbjct: 2644 TCSARNSAGVAHKHVFLTVQASPVVKP 2670
Score = 108 bits (271), Expect = 2e-23
Identities = 99/348 (28%), Positives = 149/348 (42%), Gaps = 28/348 (8%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPAT 121
P V+W G +L V + + AL H GRY C AR AG VA
Sbjct: 2602 PAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHA-GRYTCSARNSAG-VAHKHVF 2659
Query: 122 VTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRG-NYLIM 180
+T+ K + V+ ++ C P+ + + ++E L + G + ++
Sbjct: 2660 LTVQASPVVK-PLPSVVRAVAEEEVLLPCEA-SGIPRPTITW--QKEGLNVATGVSTQVL 2715
Query: 181 PSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYP--PEAQ 238
P G L+I +AS ED G Y C A N ++GS+ + R + +I P+
Sbjct: 2716 PGGQLRIAHASPEDAGNYLCIAKN-------SAGSA--MGKTRLVVQVPPVIENGLPDLS 2766
Query: 239 TIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLS---NLLIDTTSEEDSG 295
T T+G L C A G P P +TW KDG V+G + +F + LL+ +D+G
Sbjct: 2767 T---TEGSHAFLPCKARGSPEPNITWDKDGQPVSGA-EGKFTIQPSGELLVKNLEGQDAG 2822
Query: 296 TYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVL 355
TY C A+N VG+ V ++ + P T + G L C RG+P P +
Sbjct: 2823 TYTCTAENAVGRARRRV---HLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIG 2879
Query: 356 WLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAV 403
W N P+ + L+ ++ ED G Y C AEN VG AV
Sbjct: 2880 WTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAV 2927
Score = 108 bits (271), Expect = 2e-23
Identities = 94/352 (26%), Positives = 150/352 (42%), Gaps = 38/352 (10%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAG-------- 113
P N+TW +G+ ++G++ + + G L++ L G Y C A G
Sbjct: 2783 PEPNITWDKDGQPVSGAEGKFTIQPS-GELLVKNLEGQDAGTYTCTAENAVGRARRRVHL 2841
Query: 114 AVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEAS 173
+ +P TL + +L G+ + C S P ++ ++V +
Sbjct: 2842 TILVLPVFTTLPGDRSLRL----------GDRLWLRCAARGS-PTPRIGWTVNDR--PVT 2888
Query: 174 RGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIY 233
G LQ S+ED G Y C A N V + S + A ++
Sbjct: 2889 EGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVH---------VKEAPVLQ 2939
Query: 234 PPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN--LLIDTTSE 291
++ G S+ L+CV G P P + W KDG + G + R L N L I T
Sbjct: 2940 GEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRG-SHLRHQLQNGSLTIRRTER 2998
Query: 292 EDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPP 351
+D+G Y+C+A+N +G VIL + P +E + + G L C+ G P
Sbjct: 2999 DDAGRYQCLAENEMGVAKKVVILV---LQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT 3055
Query: 352 PSVLWLRNAVPLISSQRLR-LSRRALRVLSMGPEDEGVYQCMAENEVGSAHA 402
P++ WL+ PL +S+RLR L +L + ++ D G Y C+A N +GSA A
Sbjct: 3056 PTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATA 3107
Score = 108 bits (270), Expect = 3e-23
Identities = 114/449 (25%), Positives = 175/449 (38%), Gaps = 66/449 (14%)
Query: 41 QPASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNH 99
QP PG + L C + P+ N+TW +G+ L + + + L
Sbjct: 2219 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTR--------LENNSRATRVLRVR 2270
Query: 100 TVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQ------------HVIEVDEGNTAV 147
G Y C+A PAGA+ + F++ VQ V+ + G V
Sbjct: 2271 DAGLYTCLAESPAGAIE-----------KSFRVRVQAPPNIVGPRGPRFVVGLAPGQL-V 2318
Query: 148 IACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVT 207
+ C + E+ P ++ + L+ LQ+ S D G Y C A N
Sbjct: 2319 LECSV-EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA- 2376
Query: 208 QEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKD 267
+S RV T R P + V+ Q+ +L C A G+P P V+W KD
Sbjct: 2377 -----GSTSVAFRVEIHTVPTIRSGPP----AVNVSVNQTALLPCQADGVPAPLVSWRKD 2427
Query: 268 GSSVTGYNKTRFLL--SNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEV 325
+ + +L +L I +D+G Y C+A N G +++V EPP +
Sbjct: 2428 RVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQG---RDLRVLEPPAI 2484
Query: 326 TMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLI-----SSQRLRLSRRALRVLS 380
S L + A L CE G+P P V+W ++ L + RL L AL + +
Sbjct: 2485 APSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRL-LPSNALLLTA 2543
Query: 381 MGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQ 440
GP+D ++C+ NEVG AH + Q+ P P + D T T + P
Sbjct: 2544 PGPQDSAQFECVVSNEVGEAHRLYQVTVHVP---PTIADDQTDFTVT-------MMAPVV 2593
Query: 441 MLRGQPALPRPPTSVGPASPQCPGEKGQG 469
+ +P P S A Q G +G G
Sbjct: 2594 LTCHSTGIPAPTVSWSKAGAQL-GARGSG 2621
Score = 107 bits (268), Expect = 5e-23
Identities = 114/446 (25%), Positives = 172/446 (38%), Gaps = 51/446 (11%)
Query: 50 GGTVILGC-VVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVA 108
G T L C V P+ +TW +G+ L DA + L + N + G Y C+A
Sbjct: 1178 GQTAHLMCNVTGHPQPKLTWFKDGRPL-ARGDAHHISPDGVLLQVLQANLSSAGHYSCIA 1236
Query: 109 RMPAGA------VASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVR 162
G ++ + A L +D + V N + C + P +
Sbjct: 1237 ANAVGEKTKHFQLSVLLAPTILGGAED---SADEEVTVTVNNPISLICEAL-AFPSPNIT 1292
Query: 163 YSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVR 222
+ EASR L+ + LQI+NA +ED G Y C N + + VK +
Sbjct: 1293 WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 1352
Query: 223 RSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLS 282
S + + E +T + +L LEC + +PPP + W KDG VT ++ + L
Sbjct: 1353 ISKDDPLAEVGVKEVKTKV---NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGE 1409
Query: 283 N--LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPP--------EVTMEL--- 329
L I T DSG Y C+A N G+ +NV + PP E+
Sbjct: 1410 GRLLQIQPTQVSDSGRYLCVATNVAGEDDQD---FNVLIQVPPMFQKVGDFSAAFEILSR 1466
Query: 330 ---------SQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSR--RALRV 378
I A L C+ PPP + W R PL + + + + R L++
Sbjct: 1467 EEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQI 1526
Query: 379 LSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSI----TPRLWQDAEL-ATGTPPVSPS 433
+ E+ G Y C A NEVG +L P + T L ++ + A+ T +
Sbjct: 1527 PLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCP 1586
Query: 434 KLGNP----EQMLRGQPALPRPPTSV 455
LGNP + G P P P V
Sbjct: 1587 ALGNPVPTISWLQNGLPFSPSPRLQV 1612
Score = 105 bits (261), Expect = 3e-22
Identities = 104/411 (25%), Positives = 162/411 (39%), Gaps = 35/411 (8%)
Query: 52 TVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARM 110
+V L C V P VTW + + L+ ++ + TH TL + G Y C A
Sbjct: 1672 SVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH-TLQLGRARLSDSGMYTCEALN 1730
Query: 111 PAGAVASVPATVTLAN--LQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQE 168
AG + L + Q + V G+ AV++C ++ P+ V + +
Sbjct: 1731 AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET-DALPEPTVTWYKDGQ 1789
Query: 169 WLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEA 228
L ++ + L+I A D+G+Y C N + V+T T +
Sbjct: 1790 PLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTF---------TLTVQV 1840
Query: 229 ARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKD-----GSSVTGYNKTRFLLSN 283
P+ +T+ G L+L C SG+P P VTW KD S+V G
Sbjct: 1841 PPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRG---GR 1897
Query: 284 LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTME--LSQLVIPWGQSAK 341
L + +GTY C+A+N + + V V P + + + GQ +
Sbjct: 1898 LQLSRLQPAQAGTYTCVAENTQAEARKDFV---VAVLVAPRIRSSGVAREHHVLEGQEVR 1954
Query: 342 LTCEVRGNPPPSVLWLRNAVPLISSQ----RLRLSRRALRVLSMGPEDEGVYQCMAENEV 397
L CE G PPP V WL++ PL R L +L + + D G Y C+A N
Sbjct: 1955 LDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPA 2014
Query: 398 GSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPAL 448
G +L T + P + Q A+ +GT P +L +RG P +
Sbjct: 2015 GED---ARLHTVNVLVPPTIKQGAD-GSGTLVSRPGELVTMVCPVRGSPPI 2061
Score = 104 bits (259), Expect = 5e-22
Identities = 101/375 (26%), Positives = 154/375 (41%), Gaps = 26/375 (6%)
Query: 50 GGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVA 108
G +L C + P VTW +G+ L + L L I G Y C
Sbjct: 1765 GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQA-LRGGQRLEIQEAQVSDKGLYSCKV 1823
Query: 109 RMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQE 168
AG T+T+ F+ + G+ V+ C + P V + +
Sbjct: 1824 SNVAGEAVRT-FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAPTVTWLKDRM 1881
Query: 169 WLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEA 228
+E+S + ++ G LQ+ G Y C A N + K + + R ++
Sbjct: 1882 PVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGV 1941
Query: 229 ARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNK---TRFLLS--N 283
AR + V +GQ + L+C A G PPP V W KDGS + G + RF L +
Sbjct: 1942 AREHH--------VLEGQEVRLDCEADGQPPPDVAWLKDGSPL-GQDMGPHLRFYLDGGS 1992
Query: 284 LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELS---QLVIPWGQSA 340
L++ D+G Y C+A N G+ L+ V V PP + LV G+
Sbjct: 1993 LVLKGLRASDAGAYTCVAHNPAGEDAR---LHTVNVLVPPTIKQGADGSGTLVSRPGELV 2049
Query: 341 KLTCEVRGNPPPSVLWLRNAVPLISSQRLRL--SRRALRVLSMGPEDEGVYQCMAENEVG 398
+ C VRG+PP V WL++ +PL SQR L S LR+ + D G++ C+A + G
Sbjct: 2050 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG 2109
Query: 399 SAHAVVQLRTSRPSI 413
A L+ P +
Sbjct: 2110 VADRNFTLQVQVPPV 2124
Score = 99.8 bits (247), Expect = 1e-20
Identities = 93/378 (24%), Positives = 145/378 (38%), Gaps = 38/378 (10%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPAT 121
P N+TW +G S + + THG ++ A G+Y CV G
Sbjct: 1287 PSPNITWMKDGAPFEASRNIQLLPGTHGLQILNA-QKEDAGQYTCVVTNELGEAVKNYHV 1345
Query: 122 VTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESH----PKAQVRYSVKQEWLEASRGNY 177
L K D + V E T V + E P +R+ + + S
Sbjct: 1346 EVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQ 1405
Query: 178 LIMPSGNLQIVNASQEDEGMYKCAAYN----------------PVTQEVKTSGSSDRLRV 221
++ LQI D G Y C A N P+ Q+V ++ +
Sbjct: 1406 VLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILS 1465
Query: 222 RRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLL 281
R A Y + + L C + IPPP +TW ++ ++ ++ L
Sbjct: 1466 REEEARGGVTEYRE------IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ 1519
Query: 282 SN--LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLV----IP 335
L I E++G Y C A N VG+ + Y + V PP + + +LV +
Sbjct: 1520 GGRVLQIPLVRAENAGRYSCKASNEVGEDW---LHYELLVLTPPVILGDTEELVEEVTVN 1576
Query: 336 WGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL--SRRALRVLSMGPEDEGVYQCMA 393
+ L C GNP P++ WL+N +P S RL++ + L+V + D Y C+A
Sbjct: 1577 ASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVA 1636
Query: 394 ENEVGSAHAVVQLRTSRP 411
EN+ GSA + LR P
Sbjct: 1637 ENQAGSAEKLFTLRVQVP 1654
Score = 96.3 bits (238), Expect = 1e-19
Identities = 82/283 (28%), Positives = 124/283 (43%), Gaps = 33/283 (11%)
Query: 185 LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTK 244
LQI DEG+Y CAA N +G S R A +++ PP + V K
Sbjct: 568 LQIEKVDLRDEGIYTCAATN-------LAGESKR-------EVALKVLVPPNIEPGPVNK 613
Query: 245 G----QSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN--LLIDTTSEEDSGTYR 298
S+ LEC+ASG+PPP V+W K V+ + + L I+ D+G+YR
Sbjct: 614 AVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYR 673
Query: 299 CMADNGVGQPGAAVILYNVQVFEPPEVTMELS-QLVIPWGQSAKLTCEVRGNPPPSVLWL 357
C+A N G+ + Y ++V PP +T+ S + +LTC G P P+++WL
Sbjct: 674 CVASN---VAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWL 730
Query: 358 RNAVPLISSQRLRL----SRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSR-PS 412
++ P+ + L R L + S D G Y C+A + VG V L+ PS
Sbjct: 731 KDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS 790
Query: 413 ITPRLWQDAELATGTPPVSPSKLGNPEQMLR----GQPALPRP 451
I + +A + + P +L G+P PRP
Sbjct: 791 ILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRP 833
Score = 96.3 bits (238), Expect = 1e-19
Identities = 139/557 (24%), Positives = 205/557 (36%), Gaps = 81/557 (14%)
Query: 46 VQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDDALGVLITHG---TLVITALNNHTV 101
V +PG V + C V P ++V+W +G L S L HG TL I+ +
Sbjct: 2042 VSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTL----LHGSGHTLRISKVQLADA 2097
Query: 102 GRYQCVARMPAGAVASVPATVTLANLQDFKLDVQ--HVIEVDE--GNTAVIACHLPESHP 157
G + CVA PAG ++F L VQ V+E E + V+ L E
Sbjct: 2098 GIFTCVAASPAGVAD-----------RNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPC 2146
Query: 158 KAQVRYSVKQEWLEASRGNYLIMPS----GNLQIVNASQEDEGMYKCAAYNPVTQEVKTS 213
+A+ W++ G L+ S +LQ+ D G Y C A V +
Sbjct: 2147 EARGVPLPLVSWMKD--GEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVA-------VSEA 2197
Query: 214 GSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTG 273
G + R + + E I + + +T G + L C A G P P +TW KDG ++T
Sbjct: 2198 GEARR-HFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTR 2256
Query: 274 YNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLV 333
L + D+G Y C+A++ GA + V+V PP +
Sbjct: 2257 LENNSRATRVLRV-----RDAGLYTCLAES---PAGAIEKSFRVRVQAPPNIVGPRGPRF 2308
Query: 334 IPW---GQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRA--LRVLSMGPEDEGV 388
+ GQ L C V P P + W R+ + L + R L++ ++ D G
Sbjct: 2309 VVGLAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGD 2367
Query: 389 YQCMAENEVGSA--------HAVVQLRTSRPSITPRLWQDAEL---ATGTP--------- 428
Y C A N GS H V +R+ P++ + Q A L A G P
Sbjct: 2368 YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 2427
Query: 429 -----PVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAP---AEAPIILSS 480
P SP PE LR QP L + + G QG E P I S
Sbjct: 2428 RVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPS 2487
Query: 481 PRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLD 540
P ++ P P++ + +K+ +P+N L LT
Sbjct: 2488 PSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSN--ALLLTAPG 2545
Query: 541 PGSLYEVEMAAYNCAGE 557
P + E N GE
Sbjct: 2546 PQDSAQFECVVSNEVGE 2562
Score = 95.5 bits (236), Expect = 2e-19
Identities = 93/395 (23%), Positives = 158/395 (40%), Gaps = 64/395 (16%)
Query: 36 PQVTVQPASTVQKPGGTVILGCVVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITA 95
P+ S VQ T+ +PP VTW +G+ + G++ L + +L +
Sbjct: 979 PREPPTQVSVVQDGVATLECNATGKPPP-TVTWERDGQPV-GAELGLQLQNQGQSLHVER 1036
Query: 96 LNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDV----QHVIEVDEGNTAVIACH 151
GRY CVA AG + F+L V + + ++D A H
Sbjct: 1037 AQAAHTGRYSCVAENLAGRAE-----------RKFELSVLVPPELIGDLDPLTNITAALH 1085
Query: 152 LPESH-------PKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYN 204
P + P +R+ +E + YL+ L++ ++D G+Y C A N
Sbjct: 1086 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASN 1145
Query: 205 PVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQT------IIVTKGQSLILECVASGIP 258
+ RR+ + ++ PP + I V GQ+ L C +G P
Sbjct: 1146 EAGE------------ARRNFS--VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHP 1191
Query: 259 PPRVTWAKDGSSVTGYNKTRFLLSNLLIDT--TSEEDSGTYRCMADNGVGQPG------- 309
P++TW KDG + + +L+ + +G Y C+A N VG+
Sbjct: 1192 QPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSV 1251
Query: 310 --AAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQ 367
A IL + EVT+ ++ + L CE P P++ W+++ P +S+
Sbjct: 1252 LLAPTILGGAEDSADEEVTVTVNNPI-------SLICEALAFPSPNITWMKDGAPFEASR 1304
Query: 368 RLRL--SRRALRVLSMGPEDEGVYQCMAENEVGSA 400
++L L++L+ ED G Y C+ NE+G A
Sbjct: 1305 NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEA 1339
Score = 92.0 bits (227), Expect = 3e-18
Identities = 143/578 (24%), Positives = 215/578 (37%), Gaps = 91/578 (15%)
Query: 48 KPGGTVILGC---VVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRY 104
K T+ L C V PP + W +G+ + S L VL L I GRY
Sbjct: 1370 KVNSTLTLECESWAVPPP--TIRWYKDGQPVTPSS-RLQVLGEGRLLQIQPTQVSDSGRY 1426
Query: 105 QCVARMPAG-------AVASVP-----------ATVTLANLQDFKLDVQHVIEVDEGNTA 146
CVA AG + VP A L+ ++ + V E+ E N A
Sbjct: 1427 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 1486
Query: 147 VIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGN--LQIVNASQEDEGMYKCAAYN 204
+ C P Y Q S G+ + + G LQI E+ G Y C A N
Sbjct: 1487 YLYCDTNAIPPPDLTWYREDQP---LSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASN 1543
Query: 205 PVTQEVKTSGSSDRLRVRRSTAEAARIIYPPE--AQTIIVTKGQSLILECVASGIPPPRV 262
V + D L I+ E + + V ++ L+C A G P P +
Sbjct: 1544 EVGE--------DWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTI 1595
Query: 263 TWAKDGSSVTGYNKTRFLLSNLLIDTTSEE--DSGTYRCMADNGVGQPGAAVILYNVQVF 320
+W ++G + + + L ++ ++ E D+ +Y C+A+N Q G+A L+ ++V
Sbjct: 1596 SWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAEN---QAGSAEKLFTLRVQ 1652
Query: 321 EPPEVT-MELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL--SRRALR 377
PP + ++L Q+ S L C+V +P P V W +++ L + + L L+
Sbjct: 1653 VPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQ 1712
Query: 378 VLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSI---TPRLWQDAEL----------- 423
+ D G+Y C A N G +VQL P PR QDA L
Sbjct: 1713 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSC 1772
Query: 424 ---ATGTPPVSPSKLGNP------EQMLRGQPALPRPPTSV---GPASPQCPGEKGQGA- 470
A P V+ K G P Q LRG L V G S + G+
Sbjct: 1773 ETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVR 1832
Query: 471 ----PAEAPIILSSPRT---SKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWT 523
+ P +P+T S+ LV G + + +K R SS
Sbjct: 1833 TFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTW--LKDRMPVESS---A 1887
Query: 524 ISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTA 561
+ G+ + RL L+RL P + Y C E A
Sbjct: 1888 VHGVVSRGGRLQLSRLQP-----AQAGTYTCVAENTQA 1920
Score = 86.3 bits (212), Expect = 1e-16
Identities = 75/283 (26%), Positives = 121/283 (42%), Gaps = 28/283 (9%)
Query: 175 GNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYP 234
G+ L+ +L + D G+Y C A N + T+ L V + ++
Sbjct: 79 GHRLLDEGQSLHFPRIQEGDSGLYSCRAEN----QAGTAQRDFHLLVLTPPS----VLGA 130
Query: 235 PEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN---LLIDTTSE 291
AQ ++ G + L+C SG+P P+V W KD V + + L I +
Sbjct: 131 GAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV 190
Query: 292 EDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEV--TMELSQLVIPWGQSAKLTCEVRGN 349
D G Y+C+A + GQ + ++V PP + + E ++ + +L CE RG
Sbjct: 191 GDEGRYQCVAFSPAGQQARD---FQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGV 247
Query: 350 PPPSVLWLRNAVPLISSQRLRLSR--RALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLR 407
P P++ W ++ L +S ++ +R R L++ D GVY C A N VG+A +L
Sbjct: 248 PTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLD 307
Query: 408 TSRPSITPRLWQDAELATGTPPVSPSKLGNP---EQMLRGQPA 447
P E A G P V + G P E + RG P+
Sbjct: 308 VYVP-------PTIEGAGGRPYVVKAVAGRPVALECVARGHPS 343
Score = 84.3 bits (207), Expect = 6e-16
Identities = 111/455 (24%), Positives = 172/455 (37%), Gaps = 51/455 (11%)
Query: 32 LNEVPQVTVQPASTVQKPGGTVI-----LGC-VVEPPRMNVTWRLNGKELNGSDDALGVL 85
+N P++T+ P+ PG ++ L C P + W +G ++ + G+
Sbjct: 691 VNVPPRITLPPSL----PGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTP-GLQ 745
Query: 86 ITHGTLVITALNNHTV--GRYQCVARMPAGAVASVPATVTL-ANLQDFKLDVQHVIEVDE 142
+ G V+T + GRY CVA AV V L ++ L + + V
Sbjct: 746 VFPGGRVLTLASARASDSGRYSCVA---VSAVGEDRQDVVLQVHMPPSILGEELNVSVVA 802
Query: 143 GNTAVIACHLPESH--PKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKC 200
+ + C +SH P + + LE G +L LQ+ A D G Y C
Sbjct: 803 NESVALEC---QSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTC 859
Query: 201 AAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPP 260
A N K + A + E+ T+ V +G L C G+P P
Sbjct: 860 EALNQAGHSEKHYNLN---------VWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFP 910
Query: 261 RVTWAKDGSSVTGYNKTRFLLSN----LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYN 316
+++W KDG + G +S L + GTY C N VG +
Sbjct: 911 KISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDL---Q 967
Query: 317 VQVFEPPEVT---MELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSR 373
++V PP++ +Q+ + A L C G PPP+V W R+ P+ + L+L
Sbjct: 968 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQN 1027
Query: 374 --RALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVS 431
++L V G Y C+AEN G A +L P P L D + T
Sbjct: 1028 QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVP---PELIGDLDPLTNI---- 1080
Query: 432 PSKLGNPEQMLRGQPALPRPPTS-VGPASPQCPGE 465
+ L +P +L +P P P PGE
Sbjct: 1081 TAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGE 1115
Score = 73.2 bits (178), Expect = 1e-12
Identities = 58/200 (29%), Positives = 83/200 (41%), Gaps = 28/200 (14%)
Query: 245 GQSLILECVASGIPPPRVTWAKDGSSV-----------------TGYNKTRFLLSNLLID 287
GQSL LEC A+G P P + W KD V G ++ +L
Sbjct: 33 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFP 92
Query: 288 TTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEV--TMELSQLVIPWGQSAKLTCE 345
E DSG Y C A+N Q G A +++ V PP V +++ G +L C
Sbjct: 93 RIQEGDSGLYSCRAEN---QAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCW 149
Query: 346 VRGNPPPSVLWLRNAVPLISS---QRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHA 402
G P P V W ++ P++ +++ + LR+ DEG YQC+A + G
Sbjct: 150 TSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQAR 209
Query: 403 VVQLRTSRPSITPRLWQDAE 422
QLR P P +W E
Sbjct: 210 DFQLRVHAP---PTIWGSNE 226
Score = 60.8 bits (146), Expect = 7e-09
Identities = 57/203 (28%), Positives = 86/203 (42%), Gaps = 15/203 (7%)
Query: 4 GTMTAWRGMRPEVTLACLLLATAGCFADLNEVPQVTVQPASTVQKP-GGTVILGCVVE-P 61
GT W R T A F + E P + + S + +P GG++ L CVV
Sbjct: 2911 GTYVCWAENRVGRTQAV-------SFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD 2963
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPAT 121
P ++ W +G L GS L + +G+L I GRYQC+A G VA
Sbjct: 2964 PVPDIHWIKDGLPLRGSH--LRHQLQNGSLTIRRTERDDAGRYQCLAENEMG-VAKKVVI 3020
Query: 122 VTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMP 181
+ L + F+++ Q + V G+ + C P + + + L ASR +P
Sbjct: 3021 LVLQSAPVFQVEPQDMT-VRSGDDVALRCQAT-GEPTPTIEWLQAGQPLRASR-RLRTLP 3077
Query: 182 SGNLQIVNASQEDEGMYKCAAYN 204
G+L + N D G Y C A+N
Sbjct: 3078 DGSLWLENVETGDAGTYDCVAHN 3100
Score = 56.6 bits (135), Expect = 1e-07
Identities = 68/293 (23%), Positives = 113/293 (38%), Gaps = 40/293 (13%)
Query: 35 VPQVTVQPASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDDALGVLITHG--TL 91
+P T P + G + L C P + W +N + + GV G TL
Sbjct: 2846 LPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTE-----GVSEQDGGSTL 2900
Query: 92 VITALNNHTVGRYQCVARMPAGAVASVPAT----VTLANLQDFKLDVQHVIEVDEGNTAV 147
A++ G Y C A G +V + + F V+ V + + V
Sbjct: 2901 QRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV 2960
Query: 148 IACHLPESHPKAQVRYSVKQEWLEAS---RGNYLI--MPSGNLQIVNASQEDEGMYKCAA 202
+P+ H W++ RG++L + +G+L I ++D G Y+C A
Sbjct: 2961 RGDPVPDIH------------WIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLA 3008
Query: 203 YNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRV 262
N + K + V +S ++ E Q + V G + L C A+G P P +
Sbjct: 3009 ENEMGVAKKVV-----ILVLQSAP-----VFQVEPQDMTVRSGDDVALRCQATGEPTPTI 3058
Query: 263 TWAKDGSSVTGYNKTRFLLS-NLLIDTTSEEDSGTYRCMADNGVGQPGAAVIL 314
W + G + + R L +L ++ D+GTY C+A N +G A L
Sbjct: 3059 EWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFL 3111
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 137 bits (346), Expect = 4e-32
Identities = 135/444 (30%), Positives = 190/444 (42%), Gaps = 58/444 (13%)
Query: 38 VTVQPASTVQKPGGTVILGCVVEP----------PRMNVTWRLNGKELNGSDDALGVLIT 87
+TVQ AS V KP +V+ E PR +TW+ G LN + ++
Sbjct: 2751 LTVQ-ASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG--LNVATGVSTQVLP 2807
Query: 88 HGTLVITALNNHTVGRYQCVARMPAGA-------VASVPATVTLANLQDFKLDVQHVIEV 140
G L I + G Y C+A+ AG+ V VP + L D +
Sbjct: 2808 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIE-NGLPD--------LST 2858
Query: 141 DEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKC 200
EG+ A + C S P+ + + + + + G + I PSG L + N +D G Y C
Sbjct: 2859 TEGSHAFLPCKARGS-PEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTC 2917
Query: 201 AAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPP 260
A N V + R RV + P +++ + G L L C A G P P
Sbjct: 2918 TAENAVGRA--------RRRVHLTILVLPVFTTLPGDRSLRL--GDRLWLRCAARGSPTP 2967
Query: 261 RVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVF 320
R+ W + VT + S L S EDSGTY C A+N VG+ A V V
Sbjct: 2968 RIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF---VHVK 3024
Query: 321 EPPEVTME-LSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQ-RLRLSRRALRV 378
E P + E S LV P G S +L C VRG+P P + W+++ +PL S R +L +L +
Sbjct: 3025 EAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTI 3084
Query: 379 LSMGPEDEGVYQCMAENEVGSAHAVVQL--------RTSRPSITPRLWQDAEL---ATG- 426
+D G YQC+AENE+G A VV L + +T R D L ATG
Sbjct: 3085 HRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGE 3144
Query: 427 -TPPVSPSKLGNPEQMLRGQPALP 449
TP + + G P + R LP
Sbjct: 3145 PTPTIEWLQAGQPLRASRRLRTLP 3168
Score = 110 bits (274), Expect = 1e-23
Identities = 118/460 (25%), Positives = 181/460 (39%), Gaps = 68/460 (14%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPAT 121
P V W + + + L V L IT + GRYQCVA PAG A
Sbjct: 245 PTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQA----- 299
Query: 122 VTLANLQDFKLDVQHVIEV----DEGNTAVIACHLPE------SHPKAQVRYSVKQEWLE 171
+DF+L V + + G AV+ HL + P + + L
Sbjct: 300 ------RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLP 353
Query: 172 ASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARI 231
S LQ+ A D G+Y C A N V G++++ A +
Sbjct: 354 TSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAV-------GAAEK-------ATRLDV 399
Query: 232 IYPPEAQ-------TIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLL--S 282
PP + + G+ + LECVA G P P ++W +G V N++R S
Sbjct: 400 YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGS 459
Query: 283 NLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPE--VTMELSQLVIPWGQSA 340
L +++ E SG Y C+A + G+ AV+ Y+V+V PP+ V L Q+ GQ
Sbjct: 460 VLRLESPGEASSGLYSCVASSPAGE---AVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPL 516
Query: 341 KLTCEVRGNPPPSVLWLRNAVPL--ISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVG 398
+L C+ G+P P++ WL+N P ++ ++ L + + + G++ C A NE G
Sbjct: 517 ELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 576
Query: 399 SAHAVVQLRTSRPSITPRLWQDAELAT-------GTPPVSPSKLGNPEQMLRGQPALPRP 451
+A A V++ W L G S + RG A P+P
Sbjct: 577 TAGAEVEVSVHGE------WAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKP 630
Query: 452 PTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYEL 491
P G SP G P P+ S P + + +L
Sbjct: 631 PLVEGWCSP----GSLWGEPTGIPVAYSLPPPLQIEKVDL 666
Score = 110 bits (274), Expect = 1e-23
Identities = 114/387 (29%), Positives = 156/387 (40%), Gaps = 35/387 (9%)
Query: 42 PASTVQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGT-LVITALNNH 99
P V G ++L C VE P +TW +G L +DA G L + AL+
Sbjct: 2397 PRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQ--EDAHTQFPERGRFLQLQALSTA 2454
Query: 100 TVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKA 159
G Y C AR AG+ SV V + + + + V TA++ C + P
Sbjct: 2455 DSGDYSCTARNAAGST-SVAFRVEIHTVPTIRSGPP-AVNVSVNQTALLPCQA-DGVPAP 2511
Query: 160 QVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDR- 218
V + + L+ + I+P G+L+I +D G Y C A N S SDR
Sbjct: 2512 LVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASN--------SAGSDRQ 2563
Query: 219 ---LRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVT--- 272
LRV A A P + +T +L C ASG P P V W KDG +
Sbjct: 2564 GRDLRVLEPPAIA------PSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL 2617
Query: 273 GYNKTRFLLSN-LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQ 331
R L SN LL+ +DS + C+ N VG+ A LY V V PP + + +
Sbjct: 2618 QQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGE---AHRLYQVTVHVPPTIADDQTD 2674
Query: 332 LVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPL-ISSQRLRLSRR-ALRVLSMGPEDEGVY 389
+ LTC G P P+V W + L R+S AL + P G Y
Sbjct: 2675 FTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRY 2734
Query: 390 QCMAENEVGSAHAVVQLRT-SRPSITP 415
C A N G AH V L + P + P
Sbjct: 2735 TCSARNSAGVAHKHVFLTVQASPVVKP 2761
Score = 109 bits (272), Expect = 2e-23
Identities = 94/352 (26%), Positives = 150/352 (42%), Gaps = 38/352 (10%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAG-------- 113
P N+TW +G+ ++G++ + + G L++ L G Y C A G
Sbjct: 2874 PEPNITWDKDGQPVSGAEGKFTIQPS-GELLVKNLEGQDAGTYTCTAENAVGRARRRVHL 2932
Query: 114 AVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEAS 173
+ +P TL + +L G+ + C S P ++ ++V +
Sbjct: 2933 TILVLPVFTTLPGDRSLRL----------GDRLWLRCAARGS-PTPRIGWTVNDR--PVT 2979
Query: 174 RGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIY 233
G LQ S+ED G Y C A N V + S + A ++
Sbjct: 2980 EGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVH---------VKEAPVLQ 3030
Query: 234 PPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN--LLIDTTSE 291
++ G S+ L+CV G P P + W KDG + G + R L N L I T
Sbjct: 3031 GEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRG-SHLRHQLQNGSLTIHRTER 3089
Query: 292 EDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPP 351
+D+G Y+C+A+N +G VIL + P +E + + G L C+ G P
Sbjct: 3090 DDAGRYQCLAENEMGVAKKVVILV---LQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT 3146
Query: 352 PSVLWLRNAVPLISSQRLR-LSRRALRVLSMGPEDEGVYQCMAENEVGSAHA 402
P++ WL+ PL +S+RLR L +L + ++ D G Y C+A N +GSA A
Sbjct: 3147 PTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATA 3198
Score = 108 bits (271), Expect = 2e-23
Identities = 99/348 (28%), Positives = 149/348 (42%), Gaps = 28/348 (8%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPAT 121
P V+W G +L V + + AL H GRY C AR AG VA
Sbjct: 2693 PAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHA-GRYTCSARNSAG-VAHKHVF 2750
Query: 122 VTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRG-NYLIM 180
+T+ K + V+ ++ C P+ + + ++E L + G + ++
Sbjct: 2751 LTVQASPVVK-PLPSVVRAVAEEEVLLPCEA-SGIPRPTITW--QKEGLNVATGVSTQVL 2806
Query: 181 PSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYP--PEAQ 238
P G L+I +AS ED G Y C A N ++GS+ + R + +I P+
Sbjct: 2807 PGGQLRIAHASPEDAGNYLCIAKN-------SAGSA--MGKTRLVVQVPPVIENGLPDLS 2857
Query: 239 TIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLS---NLLIDTTSEEDSG 295
T T+G L C A G P P +TW KDG V+G + +F + LL+ +D+G
Sbjct: 2858 T---TEGSHAFLPCKARGSPEPNITWDKDGQPVSGA-EGKFTIQPSGELLVKNLEGQDAG 2913
Query: 296 TYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVL 355
TY C A+N VG+ V ++ + P T + G L C RG+P P +
Sbjct: 2914 TYTCTAENAVGRARRRV---HLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIG 2970
Query: 356 WLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAV 403
W N P+ + L+ ++ ED G Y C AEN VG AV
Sbjct: 2971 WTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAV 3018
Score = 108 bits (270), Expect = 3e-23
Identities = 114/449 (25%), Positives = 175/449 (38%), Gaps = 66/449 (14%)
Query: 41 QPASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNH 99
QP PG + L C + P+ N+TW +G+ L + + + L
Sbjct: 2310 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTR--------LENNSRATRVLRVR 2361
Query: 100 TVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQ------------HVIEVDEGNTAV 147
G Y C+A PAGA+ + F++ VQ V+ + G V
Sbjct: 2362 DAGLYTCLAESPAGAIE-----------KSFRVRVQAPPNIVGPRGPRFVVGLAPGQL-V 2409
Query: 148 IACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVT 207
+ C + E+ P ++ + L+ LQ+ S D G Y C A N
Sbjct: 2410 LECSV-EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA- 2467
Query: 208 QEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKD 267
+S RV T R P + V+ Q+ +L C A G+P P V+W KD
Sbjct: 2468 -----GSTSVAFRVEIHTVPTIRSGPP----AVNVSVNQTALLPCQADGVPAPLVSWRKD 2518
Query: 268 GSSVTGYNKTRFLL--SNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEV 325
+ + +L +L I +D+G Y C+A N G +++V EPP +
Sbjct: 2519 RVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQG---RDLRVLEPPAI 2575
Query: 326 TMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLI-----SSQRLRLSRRALRVLS 380
S L + A L CE G+P P V+W ++ L + RL L AL + +
Sbjct: 2576 APSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRL-LPSNALLLTA 2634
Query: 381 MGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQ 440
GP+D ++C+ NEVG AH + Q+ P P + D T T + P
Sbjct: 2635 PGPQDSAQFECVVSNEVGEAHRLYQVTVHVP---PTIADDQTDFTVT-------MMAPVV 2684
Query: 441 MLRGQPALPRPPTSVGPASPQCPGEKGQG 469
+ +P P S A Q G +G G
Sbjct: 2685 LTCHSTGIPAPTVSWSKAGAQL-GARGSG 2712
Score = 107 bits (267), Expect = 6e-23
Identities = 114/446 (25%), Positives = 172/446 (38%), Gaps = 51/446 (11%)
Query: 50 GGTVILGC-VVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVA 108
G T L C V P+ +TW +G+ L DA + L + N + G Y C+A
Sbjct: 1269 GQTAHLMCNVTGHPQPKLTWFKDGRPL-ARGDAHHISPDGVLLQVLQANLSSAGHYSCIA 1327
Query: 109 RMPAGA------VASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVR 162
G ++ + A L +D + V N + C + P +
Sbjct: 1328 ANAVGEKTKHFQLSVLLAPTILGGAED---SADEEVTVTVNNPISLICEAL-AFPSPNIT 1383
Query: 163 YSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVR 222
+ EASR L+ + LQI+NA +ED G Y C N + + VK +
Sbjct: 1384 WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 1443
Query: 223 RSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLS 282
S + + E +T + +L LEC + +PPP + W KDG VT ++ + L
Sbjct: 1444 ISKDDPLGEVGVKEVKTKV---NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGE 1500
Query: 283 N--LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPP--------EVTMEL--- 329
L I T DSG Y C+A N G+ +NV + PP E+
Sbjct: 1501 GRLLQIQPTQVSDSGRYLCVATNVAGEDDQD---FNVLIQVPPMFQKVGDFSAAFEILSR 1557
Query: 330 ---------SQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSR--RALRV 378
I A L C+ PPP + W R PL + + + + R L++
Sbjct: 1558 EEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQI 1617
Query: 379 LSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSI----TPRLWQDAEL-ATGTPPVSPS 433
+ E+ G Y C A NEVG +L P + T L ++ + A+ T +
Sbjct: 1618 PLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCP 1677
Query: 434 KLGNP----EQMLRGQPALPRPPTSV 455
LGNP + G P P P V
Sbjct: 1678 ALGNPVPTISWLQNGLPFSPSPRLQV 1703
Score = 105 bits (261), Expect = 3e-22
Identities = 104/411 (25%), Positives = 162/411 (39%), Gaps = 35/411 (8%)
Query: 52 TVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARM 110
+V L C V P VTW + + L+ ++ + TH TL + G Y C A
Sbjct: 1763 SVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH-TLQLGRARLSDSGMYTCEALN 1821
Query: 111 PAGAVASVPATVTLAN--LQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQE 168
AG + L + Q + V G+ AV++C ++ P+ V + +
Sbjct: 1822 AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET-DALPEPTVTWYKDGQ 1880
Query: 169 WLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEA 228
L ++ + L+I A D+G+Y C N + V+T T +
Sbjct: 1881 PLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTF---------TLTVQV 1931
Query: 229 ARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKD-----GSSVTGYNKTRFLLSN 283
P+ +T+ G L+L C SG+P P VTW KD S+V G
Sbjct: 1932 PPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRG---GR 1988
Query: 284 LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTME--LSQLVIPWGQSAK 341
L + +GTY C+A+N + + V V P + + + GQ +
Sbjct: 1989 LQLSRLQPAQAGTYTCVAENTQAEARKDFV---VAVLVAPRIRSSGVAREHHVLEGQEVR 2045
Query: 342 LTCEVRGNPPPSVLWLRNAVPLISSQ----RLRLSRRALRVLSMGPEDEGVYQCMAENEV 397
L CE G PPP V WL++ PL R L +L + + D G Y C+A N
Sbjct: 2046 LDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPA 2105
Query: 398 GSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPAL 448
G +L T + P + Q A+ +GT P +L +RG P +
Sbjct: 2106 GED---ARLHTVNVLVPPTIKQGAD-GSGTLVSRPGELVTMVCPVRGSPPI 2152
Score = 104 bits (259), Expect = 5e-22
Identities = 101/375 (26%), Positives = 154/375 (41%), Gaps = 26/375 (6%)
Query: 50 GGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVA 108
G +L C + P VTW +G+ L + L L I G Y C
Sbjct: 1856 GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQA-LRGGQRLEIQEAQVSDKGLYSCKV 1914
Query: 109 RMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQE 168
AG T+T+ F+ + G+ V+ C + P V + +
Sbjct: 1915 SNVAGEAVRT-FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAPTVTWLKDRM 1972
Query: 169 WLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEA 228
+E+S + ++ G LQ+ G Y C A N + K + + R ++
Sbjct: 1973 PVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGV 2032
Query: 229 ARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNK---TRFLLS--N 283
AR + V +GQ + L+C A G PPP V W KDGS + G + RF L +
Sbjct: 2033 AREHH--------VLEGQEVRLDCEADGQPPPDVAWLKDGSPL-GQDMGPHLRFYLDGGS 2083
Query: 284 LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELS---QLVIPWGQSA 340
L++ D+G Y C+A N G+ L+ V V PP + LV G+
Sbjct: 2084 LVLKGLRASDAGAYTCVAHNPAGEDAR---LHTVNVLVPPTIKQGADGSGTLVSRPGELV 2140
Query: 341 KLTCEVRGNPPPSVLWLRNAVPLISSQRLRL--SRRALRVLSMGPEDEGVYQCMAENEVG 398
+ C VRG+PP V WL++ +PL SQR L S LR+ + D G++ C+A + G
Sbjct: 2141 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG 2200
Query: 399 SAHAVVQLRTSRPSI 413
A L+ P +
Sbjct: 2201 VADRNFTLQVQVPPV 2215
Score = 100 bits (248), Expect = 1e-20
Identities = 95/380 (25%), Positives = 149/380 (39%), Gaps = 42/380 (11%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVAS---V 118
P N+TW +G S + + THG ++ A G+Y CV G V
Sbjct: 1378 PSPNITWMKDGAPFEASRNIQLLPGTHGLQILNA-QKEDAGQYTCVVTNELGEAVKNYHV 1436
Query: 119 PATVTLANLQDFKLDVQHVIEVDE--GNTAVIACHLPESHPKAQVRYSVKQEWLEASRGN 176
+ + +D L V EV +T + C P Y Q +SR
Sbjct: 1437 EVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSR-- 1494
Query: 177 YLIMPSGNLQIVNASQ-EDEGMYKCAAYN----------------PVTQEVKTSGSSDRL 219
++ G L + +Q D G Y C A N P+ Q+V ++ +
Sbjct: 1495 LQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEI 1554
Query: 220 RVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRF 279
R A Y + + L C + IPPP +TW ++ ++ ++
Sbjct: 1555 LSREEEARGGVTEYRE------IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV 1608
Query: 280 LLSN--LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLV---- 333
L L I E++G Y C A N VG+ + Y + V PP + + +LV
Sbjct: 1609 LQGGRVLQIPLVRAENAGRYSCKASNEVGEDW---LHYELLVLTPPVILGDTEELVEEVT 1665
Query: 334 IPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL--SRRALRVLSMGPEDEGVYQC 391
+ + L C GNP P++ WL+N +P S RL++ + L+V + D Y C
Sbjct: 1666 VNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMC 1725
Query: 392 MAENEVGSAHAVVQLRTSRP 411
+AEN+ GSA + LR P
Sbjct: 1726 VAENQAGSAEKLFTLRVQVP 1745
Score = 96.3 bits (238), Expect = 1e-19
Identities = 82/283 (28%), Positives = 124/283 (43%), Gaps = 33/283 (11%)
Query: 185 LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTK 244
LQI DEG+Y CAA N +G S R A +++ PP + V K
Sbjct: 659 LQIEKVDLRDEGIYTCAATN-------LAGESKR-------EVALKVLVPPNIEPGPVNK 704
Query: 245 G----QSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN--LLIDTTSEEDSGTYR 298
S+ LEC+ASG+PPP V+W K V+ + + L I+ D+G+YR
Sbjct: 705 AVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYR 764
Query: 299 CMADNGVGQPGAAVILYNVQVFEPPEVTMELS-QLVIPWGQSAKLTCEVRGNPPPSVLWL 357
C+A N G+ + Y ++V PP +T+ S + +LTC G P P+++WL
Sbjct: 765 CVASN---VAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWL 821
Query: 358 RNAVPLISSQRLRL----SRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSR-PS 412
++ P+ + L R L + S D G Y C+A + VG V L+ PS
Sbjct: 822 KDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS 881
Query: 413 ITPRLWQDAELATGTPPVSPSKLGNPEQMLR----GQPALPRP 451
I + +A + + P +L G+P PRP
Sbjct: 882 ILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRP 924
Score = 96.3 bits (238), Expect = 1e-19
Identities = 139/557 (24%), Positives = 205/557 (36%), Gaps = 81/557 (14%)
Query: 46 VQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDDALGVLITHG---TLVITALNNHTV 101
V +PG V + C V P ++V+W +G L S L HG TL I+ +
Sbjct: 2133 VSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTL----LHGSGHTLRISKVQLADA 2188
Query: 102 GRYQCVARMPAGAVASVPATVTLANLQDFKLDVQ--HVIEVDE--GNTAVIACHLPESHP 157
G + CVA PAG ++F L VQ V+E E + V+ L E
Sbjct: 2189 GIFTCVAASPAGVAD-----------RNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPC 2237
Query: 158 KAQVRYSVKQEWLEASRGNYLIMPS----GNLQIVNASQEDEGMYKCAAYNPVTQEVKTS 213
+A+ W++ G L+ S +LQ+ D G Y C A V +
Sbjct: 2238 EARGVPLPLVSWMKD--GEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVA-------VSEA 2288
Query: 214 GSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTG 273
G + R + + E I + + +T G + L C A G P P +TW KDG ++T
Sbjct: 2289 GEARR-HFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTR 2347
Query: 274 YNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLV 333
L + D+G Y C+A++ GA + V+V PP +
Sbjct: 2348 LENNSRATRVLRV-----RDAGLYTCLAES---PAGAIEKSFRVRVQAPPNIVGPRGPRF 2399
Query: 334 IPW---GQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRA--LRVLSMGPEDEGV 388
+ GQ L C V P P + W R+ + L + R L++ ++ D G
Sbjct: 2400 VVGLAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGD 2458
Query: 389 YQCMAENEVGSA--------HAVVQLRTSRPSITPRLWQDAEL---ATGTP--------- 428
Y C A N GS H V +R+ P++ + Q A L A G P
Sbjct: 2459 YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 2518
Query: 429 -----PVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAP---AEAPIILSS 480
P SP PE LR QP L + + G QG E P I S
Sbjct: 2519 RVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPS 2578
Query: 481 PRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLD 540
P ++ P P++ + +K+ +P+N L LT
Sbjct: 2579 PSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSN--ALLLTAPG 2636
Query: 541 PGSLYEVEMAAYNCAGE 557
P + E N GE
Sbjct: 2637 PQDSAQFECVVSNEVGE 2653
Score = 95.5 bits (236), Expect = 2e-19
Identities = 93/395 (23%), Positives = 158/395 (40%), Gaps = 64/395 (16%)
Query: 36 PQVTVQPASTVQKPGGTVILGCVVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITA 95
P+ S VQ T+ +PP VTW +G+ + G++ L + +L +
Sbjct: 1070 PREPPTQVSVVQDGVATLECNATGKPPP-TVTWERDGQPV-GAELGLQLQNQGQSLHVER 1127
Query: 96 LNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDV----QHVIEVDEGNTAVIACH 151
GRY CVA AG + F+L V + + ++D A H
Sbjct: 1128 AQAAHTGRYSCVAENLAGRAE-----------RKFELSVLVPPELIGDLDPLTNITAALH 1176
Query: 152 LPESH-------PKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYN 204
P + P +R+ +E + YL+ L++ ++D G+Y C A N
Sbjct: 1177 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASN 1236
Query: 205 PVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQT------IIVTKGQSLILECVASGIP 258
+ RR+ + ++ PP + I V GQ+ L C +G P
Sbjct: 1237 EAGE------------ARRNFS--VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHP 1282
Query: 259 PPRVTWAKDGSSVTGYNKTRFLLSNLLIDT--TSEEDSGTYRCMADNGVGQPG------- 309
P++TW KDG + + +L+ + +G Y C+A N VG+
Sbjct: 1283 QPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSV 1342
Query: 310 --AAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQ 367
A IL + EVT+ ++ + L CE P P++ W+++ P +S+
Sbjct: 1343 LLAPTILGGAEDSADEEVTVTVNNPI-------SLICEALAFPSPNITWMKDGAPFEASR 1395
Query: 368 RLRL--SRRALRVLSMGPEDEGVYQCMAENEVGSA 400
++L L++L+ ED G Y C+ NE+G A
Sbjct: 1396 NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEA 1430
Score = 92.0 bits (227), Expect = 3e-18
Identities = 143/578 (24%), Positives = 215/578 (37%), Gaps = 91/578 (15%)
Query: 48 KPGGTVILGC---VVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRY 104
K T+ L C V PP + W +G+ + S L VL L I GRY
Sbjct: 1461 KVNSTLTLECESWAVPPP--TIRWYKDGQPVTPSS-RLQVLGEGRLLQIQPTQVSDSGRY 1517
Query: 105 QCVARMPAG-------AVASVP-----------ATVTLANLQDFKLDVQHVIEVDEGNTA 146
CVA AG + VP A L+ ++ + V E+ E N A
Sbjct: 1518 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 1577
Query: 147 VIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGN--LQIVNASQEDEGMYKCAAYN 204
+ C P Y Q S G+ + + G LQI E+ G Y C A N
Sbjct: 1578 YLYCDTNAIPPPDLTWYREDQP---LSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASN 1634
Query: 205 PVTQEVKTSGSSDRLRVRRSTAEAARIIYPPE--AQTIIVTKGQSLILECVASGIPPPRV 262
V + D L I+ E + + V ++ L+C A G P P +
Sbjct: 1635 EVGE--------DWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTI 1686
Query: 263 TWAKDGSSVTGYNKTRFLLSNLLIDTTSEE--DSGTYRCMADNGVGQPGAAVILYNVQVF 320
+W ++G + + + L ++ ++ E D+ +Y C+A+N Q G+A L+ ++V
Sbjct: 1687 SWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAEN---QAGSAEKLFTLRVQ 1743
Query: 321 EPPEVT-MELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL--SRRALR 377
PP + ++L Q+ S L C+V +P P V W +++ L + + L L+
Sbjct: 1744 VPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQ 1803
Query: 378 VLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSI---TPRLWQDAEL----------- 423
+ D G+Y C A N G +VQL P PR QDA L
Sbjct: 1804 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSC 1863
Query: 424 ---ATGTPPVSPSKLGNP------EQMLRGQPALPRPPTSV---GPASPQCPGEKGQGA- 470
A P V+ K G P Q LRG L V G S + G+
Sbjct: 1864 ETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVR 1923
Query: 471 ----PAEAPIILSSPRT---SKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWT 523
+ P +P+T S+ LV G + + +K R SS
Sbjct: 1924 TFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTW--LKDRMPVESS---A 1978
Query: 524 ISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTA 561
+ G+ + RL L+RL P + Y C E A
Sbjct: 1979 VHGVVSRGGRLQLSRLQP-----AQAGTYTCVAENTQA 2011
Score = 85.1 bits (209), Expect = 3e-16
Identities = 111/455 (24%), Positives = 173/455 (38%), Gaps = 51/455 (11%)
Query: 32 LNEVPQVTVQPASTVQKPGGTVI-----LGC-VVEPPRMNVTWRLNGKELNGSDDALGVL 85
+N P++T+ P+ PG ++ L C P + W +G ++ + G+
Sbjct: 782 VNVPPRITLPPSL----PGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTP-GLQ 836
Query: 86 ITHGTLVITALNNHTV--GRYQCVARMPAGAVASVPATVTL-ANLQDFKLDVQHVIEVDE 142
+ G V+T + GRY CVA AV V L ++ L + + V
Sbjct: 837 VFPGGRVLTLASARASDSGRYSCVA---VSAVGEDRQDVVLQVHMPPSILGEELNVSVVA 893
Query: 143 GNTAVIACHLPESH--PKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKC 200
+ + C +SH P + + LE G +L LQ+ A D G Y C
Sbjct: 894 NESVALEC---QSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTC 950
Query: 201 AAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPP 260
A N + K + A + E+ T+ V +G L C G+P P
Sbjct: 951 EALNQAGRSEKHYNLN---------VWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFP 1001
Query: 261 RVTWAKDGSSVTGYNKTRFLLSN----LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYN 316
+++W KDG + G +S L + GTY C N VG +
Sbjct: 1002 KISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDL---Q 1058
Query: 317 VQVFEPPEVT---MELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSR 373
++V PP++ +Q+ + A L C G PPP+V W R+ P+ + L+L
Sbjct: 1059 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQN 1118
Query: 374 --RALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVS 431
++L V G Y C+AEN G A +L P P L D + T
Sbjct: 1119 QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVP---PELIGDLDPLTNI---- 1171
Query: 432 PSKLGNPEQMLRGQPALPRPPTS-VGPASPQCPGE 465
+ L +P +L +P P P PGE
Sbjct: 1172 TAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGE 1206
Score = 80.9 bits (198), Expect = 6e-15
Identities = 63/221 (28%), Positives = 99/221 (44%), Gaps = 20/221 (9%)
Query: 237 AQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN---LLIDTTSEED 293
AQ ++ G + L+C SG+P P+V W KD V + + L I + D
Sbjct: 224 AQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGD 283
Query: 294 SGTYRCMADNGVGQPGAAVILYNVQVFEPPEV--TMELSQLVIPWGQSAKLTCEVRGNPP 351
G Y+C+A + GQ + ++V PP + + E ++ + +L CE RG P
Sbjct: 284 EGRYQCVAFSPAGQQARD---FQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPT 340
Query: 352 PSVLWLRNAVPLISSQRLRLSR--RALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTS 409
P++ W ++ L +S ++ +R R L++ D GVY C A N VG+A +L
Sbjct: 341 PNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 400
Query: 410 RPSITPRLWQDAELATGTPPVSPSKLGNP---EQMLRGQPA 447
P E A G P V + G P E + RG P+
Sbjct: 401 VP-------PTIEGAGGRPYVVKAVAGRPVALECVARGHPS 434
Score = 61.6 bits (148), Expect = 4e-09
Identities = 78/307 (25%), Positives = 111/307 (36%), Gaps = 60/307 (19%)
Query: 157 PKAQV--RYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSG 214
PK QV R E L G ++ G+L + + S D G Y+C A N V G
Sbjct: 30 PKPQVTWRKGPSSEPLHGQPG-VAVLEEGSLFLASVSPADSGDYECQATNEV-------G 81
Query: 215 SSDRLRVRRSTAEAARIIYPPEA-------QTIIVTKGQSLILECVASGIPPPRVTWAKD 267
S+ R A ++Y P + + GQSL LEC A+G P P + W KD
Sbjct: 82 STSR--------RAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKD 133
Query: 268 GSSV------TGY---------NKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAV 312
V GY R L + + + R A G A
Sbjct: 134 AQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAP 193
Query: 313 ILYNVQVFE------------PPEV--TMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLR 358
+ FE PP V +++ G +L C G P P V W +
Sbjct: 194 WXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK 253
Query: 359 NAVPLISS---QRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITP 415
+ P++ +++ + LR+ DEG YQC+A + G QLR P P
Sbjct: 254 DRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP---P 310
Query: 416 RLWQDAE 422
+W E
Sbjct: 311 TIWGSNE 317
Score = 60.5 bits (145), Expect = 9e-09
Identities = 57/203 (28%), Positives = 86/203 (42%), Gaps = 15/203 (7%)
Query: 4 GTMTAWRGMRPEVTLACLLLATAGCFADLNEVPQVTVQPASTVQKP-GGTVILGCVVE-P 61
GT W R T A F + E P + + S + +P GG++ L CVV
Sbjct: 3002 GTYVCWAENRVGRTQAV-------SFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD 3054
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPAT 121
P ++ W +G L GS L + +G+L I GRYQC+A G VA
Sbjct: 3055 PVPDIHWIKDGLPLRGSH--LRHQLQNGSLTIHRTERDDAGRYQCLAENEMG-VAKKVVI 3111
Query: 122 VTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMP 181
+ L + F+++ Q + V G+ + C P + + + L ASR +P
Sbjct: 3112 LVLQSAPVFQVEPQDMT-VRSGDDVALRCQAT-GEPTPTIEWLQAGQPLRASR-RLRTLP 3168
Query: 182 SGNLQIVNASQEDEGMYKCAAYN 204
G+L + N D G Y C A+N
Sbjct: 3169 DGSLWLENVETGDAGTYDCVAHN 3191
Score = 57.8 bits (138), Expect = 6e-08
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 252 CVASGIPPPRVTWAKDGSSVTGYNKTRFLL---SNLLIDTTSEEDSGTYRCMADNGVGQP 308
C G P P+VTW K SS + + + +L + + S DSG Y C A N VG
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83
Query: 309 GAAVILYNVQVFEPPEVTMELSQLVIPW--GQSAKLTCEVRGNPPPSVLWLRNA 360
L V+ PP + + + + GQS L C+ G P P ++WL++A
Sbjct: 84 SRRAKLV---VYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDA 134
Score = 56.6 bits (135), Expect = 1e-07
Identities = 68/293 (23%), Positives = 113/293 (38%), Gaps = 40/293 (13%)
Query: 35 VPQVTVQPASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDDALGVLITHG--TL 91
+P T P + G + L C P + W +N + + GV G TL
Sbjct: 2937 LPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTE-----GVSEQDGGSTL 2991
Query: 92 VITALNNHTVGRYQCVARMPAGAVASVPAT----VTLANLQDFKLDVQHVIEVDEGNTAV 147
A++ G Y C A G +V + + F V+ V + + V
Sbjct: 2992 QRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV 3051
Query: 148 IACHLPESHPKAQVRYSVKQEWLEAS---RGNYLI--MPSGNLQIVNASQEDEGMYKCAA 202
+P+ H W++ RG++L + +G+L I ++D G Y+C A
Sbjct: 3052 RGDPVPDIH------------WIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLA 3099
Query: 203 YNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRV 262
N + K + V +S ++ E Q + V G + L C A+G P P +
Sbjct: 3100 ENEMGVAKKVV-----ILVLQSAP-----VFQVEPQDMTVRSGDDVALRCQATGEPTPTI 3149
Query: 263 TWAKDGSSVTGYNKTRFLLS-NLLIDTTSEEDSGTYRCMADNGVGQPGAAVIL 314
W + G + + R L +L ++ D+GTY C+A N +G A L
Sbjct: 3150 EWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFL 3202
Score = 39.3 bits (90), Expect = 0.021
Identities = 22/59 (37%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Query: 344 CEVRGNPPPSVLWLR--NAVPLISSQRLR-LSRRALRVLSMGPEDEGVYQCMAENEVGS 399
C G P P V W + ++ PL + L +L + S+ P D G Y+C A NEVGS
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 82
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 137 bits (346), Expect = 4e-32
Identities = 135/444 (30%), Positives = 190/444 (42%), Gaps = 58/444 (13%)
Query: 38 VTVQPASTVQKPGGTVILGCVVEP----------PRMNVTWRLNGKELNGSDDALGVLIT 87
+TVQ AS V KP +V+ E PR +TW+ G LN + ++
Sbjct: 3942 LTVQ-ASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG--LNVATGVSTQVLP 3998
Query: 88 HGTLVITALNNHTVGRYQCVARMPAGA-------VASVPATVTLANLQDFKLDVQHVIEV 140
G L I + G Y C+A+ AG+ V VP + L D +
Sbjct: 3999 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIE-NGLPD--------LST 4049
Query: 141 DEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKC 200
EG+ A + C S P+ + + + + + G + I PSG L + N +D G Y C
Sbjct: 4050 TEGSHAFLPCKARGS-PEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTC 4108
Query: 201 AAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPP 260
A N V + R RV + P +++ + G L L C A G P P
Sbjct: 4109 TAENAVGRA--------RRRVHLTILVLPVFTTLPGDRSLRL--GDRLWLRCAARGSPTP 4158
Query: 261 RVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVF 320
R+ W + VT + S L S EDSGTY C A+N VG+ A V V
Sbjct: 4159 RIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF---VHVK 4215
Query: 321 EPPEVTME-LSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQ-RLRLSRRALRV 378
E P + E S LV P G S +L C VRG+P P + W+++ +PL S R +L +L +
Sbjct: 4216 EAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTI 4275
Query: 379 LSMGPEDEGVYQCMAENEVGSAHAVVQL--------RTSRPSITPRLWQDAEL---ATG- 426
+D G YQC+AENE+G A VV L + +T R D L ATG
Sbjct: 4276 HRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGE 4335
Query: 427 -TPPVSPSKLGNPEQMLRGQPALP 449
TP + + G P + R LP
Sbjct: 4336 PTPTIEWLQAGQPLRASRRLRTLP 4359
Score = 119 bits (299), Expect = 1e-26
Identities = 124/424 (29%), Positives = 173/424 (40%), Gaps = 53/424 (12%)
Query: 36 PQVTVQPASTVQKPGGTVILGCVV--EPPRMNVTWRLNGKELNGSDDALGVLITHGTLVI 93
PQ+ P TV PG T +L C V E P N+TW + + L S + L +L I
Sbjct: 518 PQLVPAPNVTVS-PGETAVLSCRVLGEAP-YNLTWVRDWRVLPASTGRVAQLADL-SLEI 574
Query: 94 TALNNHTVGRYQCVARMPAGAV-ASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHL 152
+ + GRYQCVA G ASV V A QH +G ++C
Sbjct: 575 SGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHF---SQGVEVKVSCSA 631
Query: 153 PESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPV--TQEV 210
+P + +S + + L+ + + G L I + ED G Y C A N V QE
Sbjct: 632 -SGYPTPHISWSRESQALQEDSRIH-VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQET 689
Query: 211 KTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSS 270
T +D V A ++V G+ +L C ASG+PPPRV W + G
Sbjct: 690 VTLYYTDPPSVSAVNA------------VVLVAVGEEAVLVCEASGVPPPRVIWYRGGLE 737
Query: 271 VTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELS 330
+ L I E D+GTY C A N +G A + L V P++T
Sbjct: 738 MI-LAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL---AVGHAPQLTELPR 793
Query: 331 QLVIPWGQSAKLTCEVRGNPPPSVLWLR-NAVPL---ISSQRLRLSRR----ALRVLSMG 382
+ + G+SA L C G PPP+V W R + PL + + R SR+ L S+
Sbjct: 794 DVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 853
Query: 383 PEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQML 442
PED+ Y C A N G A +L + TG P + ++L
Sbjct: 854 PEDQAPYVCEARNVFGKVQAEARL----------------IVTGHAPPQIASSAPTVRVL 897
Query: 443 RGQP 446
GQP
Sbjct: 898 EGQP 901
Score = 114 bits (284), Expect = 7e-25
Identities = 95/342 (27%), Positives = 149/342 (43%), Gaps = 33/342 (9%)
Query: 102 GRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQV 161
G Y+C A AG A + + + + +V V G TAV++C + P
Sbjct: 492 GTYECTAVSRAGT-GRAKAQIVVTDPPPQLVPAPNVT-VSPGETAVLSCRVLGEAP---Y 546
Query: 162 RYSVKQEW--LEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRL 219
+ ++W L AS G + +L+I D G Y+C A N + R
Sbjct: 547 NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN--------ANGVTRA 598
Query: 220 RVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRF 279
V EA ++ +Q ++G + + C ASG P P ++W+++ ++ ++
Sbjct: 599 SVWLLVREAPQVSIHTSSQHF--SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV 656
Query: 280 -LLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQ 338
L+I + ED+G Y C A N VG V LY +PP V+ + +++ G+
Sbjct: 657 DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT---DPPSVSAVNAVVLVAVGE 713
Query: 339 SAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVG 398
A L CE G PPP V+W R + +I + S + LR+ + D G Y C A NE+G
Sbjct: 714 EAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK-LRIPAAQERDAGTYTCRAVNELG 772
Query: 399 SAHAVVQLRTSRP--------SITPRLWQDAEL---ATGTPP 429
A A +QL +T L + A L ATG PP
Sbjct: 773 DASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPP 814
Score = 110 bits (274), Expect = 1e-23
Identities = 118/460 (25%), Positives = 181/460 (39%), Gaps = 68/460 (14%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPAT 121
P V W + + + L V L IT + GRYQCVA PAG A
Sbjct: 1436 PTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQA----- 1490
Query: 122 VTLANLQDFKLDVQHVIEV----DEGNTAVIACHLPE------SHPKAQVRYSVKQEWLE 171
+DF+L V + + G AV+ HL + P + + L
Sbjct: 1491 ------RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLP 1544
Query: 172 ASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARI 231
S LQ+ A D G+Y C A N V G++++ A +
Sbjct: 1545 TSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAV-------GAAEK-------ATRLDV 1590
Query: 232 IYPPEAQ-------TIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLL--S 282
PP + + G+ + LECVA G P P ++W +G V N++R S
Sbjct: 1591 YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGS 1650
Query: 283 NLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPE--VTMELSQLVIPWGQSA 340
L +++ E SG Y C+A + G+ AV+ Y+V+V PP+ V L Q+ GQ
Sbjct: 1651 VLRLESPGEASSGLYSCVASSPAGE---AVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPL 1707
Query: 341 KLTCEVRGNPPPSVLWLRNAVPL--ISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVG 398
+L C+ G+P P++ WL+N P ++ ++ L + + + G++ C A NE G
Sbjct: 1708 ELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 1767
Query: 399 SAHAVVQLRTSRPSITPRLWQDAELAT-------GTPPVSPSKLGNPEQMLRGQPALPRP 451
+A A V++ W L G S + RG A P+P
Sbjct: 1768 TAGAEVEVSVHGE------WAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKP 1821
Query: 452 PTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYEL 491
P G SP G P P+ S P + + +L
Sbjct: 1822 PLVEGWCSP----GSLWGEPTGIPVAYSLPPPLQIEKVDL 1857
Score = 110 bits (274), Expect = 1e-23
Identities = 114/387 (29%), Positives = 156/387 (40%), Gaps = 35/387 (9%)
Query: 42 PASTVQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGT-LVITALNNH 99
P V G ++L C VE P +TW +G L +DA G L + AL+
Sbjct: 3588 PRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQ--EDAHTQFPERGRFLQLQALSTA 3645
Query: 100 TVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKA 159
G Y C AR AG+ SV V + + + + V TA++ C + P
Sbjct: 3646 DSGDYSCTARNAAGST-SVAFRVEIHTVPTIRSGPP-AVNVSVNQTALLPCQA-DGVPAP 3702
Query: 160 QVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDR- 218
V + + L+ + I+P G+L+I +D G Y C A N S SDR
Sbjct: 3703 LVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASN--------SAGSDRQ 3754
Query: 219 ---LRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVT--- 272
LRV A A P + +T +L C ASG P P V W KDG +
Sbjct: 3755 GRDLRVLEPPAIA------PSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL 3808
Query: 273 GYNKTRFLLSN-LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQ 331
R L SN LL+ +DS + C+ N VG+ A LY V V PP + + +
Sbjct: 3809 QQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGE---AHRLYQVTVHVPPTIADDQTD 3865
Query: 332 LVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPL-ISSQRLRLSRR-ALRVLSMGPEDEGVY 389
+ LTC G P P+V W + L R+S AL + P G Y
Sbjct: 3866 FTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRY 3925
Query: 390 QCMAENEVGSAHAVVQLRT-SRPSITP 415
C A N G AH V L + P + P
Sbjct: 3926 TCSARNSAGVAHKHVFLTVQASPVVKP 3952
Score = 109 bits (272), Expect = 2e-23
Identities = 94/352 (26%), Positives = 150/352 (42%), Gaps = 38/352 (10%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAG-------- 113
P N+TW +G+ ++G++ + + G L++ L G Y C A G
Sbjct: 4065 PEPNITWDKDGQPVSGAEGKFTIQPS-GELLVKNLEGQDAGTYTCTAENAVGRARRRVHL 4123
Query: 114 AVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEAS 173
+ +P TL + +L G+ + C S P ++ ++V +
Sbjct: 4124 TILVLPVFTTLPGDRSLRL----------GDRLWLRCAARGS-PTPRIGWTVNDR--PVT 4170
Query: 174 RGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIY 233
G LQ S+ED G Y C A N V + S + A ++
Sbjct: 4171 EGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVH---------VKEAPVLQ 4221
Query: 234 PPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN--LLIDTTSE 291
++ G S+ L+CV G P P + W KDG + G + R L N L I T
Sbjct: 4222 GEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRG-SHLRHQLQNGSLTIHRTER 4280
Query: 292 EDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPP 351
+D+G Y+C+A+N +G VIL + P +E + + G L C+ G P
Sbjct: 4281 DDAGRYQCLAENEMGVAKKVVILV---LQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT 4337
Query: 352 PSVLWLRNAVPLISSQRLR-LSRRALRVLSMGPEDEGVYQCMAENEVGSAHA 402
P++ WL+ PL +S+RLR L +L + ++ D G Y C+A N +GSA A
Sbjct: 4338 PTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATA 4389
Score = 108 bits (271), Expect = 2e-23
Identities = 99/348 (28%), Positives = 149/348 (42%), Gaps = 28/348 (8%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPAT 121
P V+W G +L V + + AL H GRY C AR AG VA
Sbjct: 3884 PAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHA-GRYTCSARNSAG-VAHKHVF 3941
Query: 122 VTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRG-NYLIM 180
+T+ K + V+ ++ C P+ + + ++E L + G + ++
Sbjct: 3942 LTVQASPVVK-PLPSVVRAVAEEEVLLPCEA-SGIPRPTITW--QKEGLNVATGVSTQVL 3997
Query: 181 PSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYP--PEAQ 238
P G L+I +AS ED G Y C A N ++GS+ + R + +I P+
Sbjct: 3998 PGGQLRIAHASPEDAGNYLCIAKN-------SAGSA--MGKTRLVVQVPPVIENGLPDLS 4048
Query: 239 TIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLS---NLLIDTTSEEDSG 295
T T+G L C A G P P +TW KDG V+G + +F + LL+ +D+G
Sbjct: 4049 T---TEGSHAFLPCKARGSPEPNITWDKDGQPVSGA-EGKFTIQPSGELLVKNLEGQDAG 4104
Query: 296 TYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVL 355
TY C A+N VG+ V ++ + P T + G L C RG+P P +
Sbjct: 4105 TYTCTAENAVGRARRRV---HLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIG 4161
Query: 356 WLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAV 403
W N P+ + L+ ++ ED G Y C AEN VG AV
Sbjct: 4162 WTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAV 4209
Score = 108 bits (270), Expect = 3e-23
Identities = 114/449 (25%), Positives = 175/449 (38%), Gaps = 66/449 (14%)
Query: 41 QPASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNH 99
QP PG + L C + P+ N+TW +G+ L + + + L
Sbjct: 3501 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTR--------LENNSRATRVLRVR 3552
Query: 100 TVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQ------------HVIEVDEGNTAV 147
G Y C+A PAGA+ + F++ VQ V+ + G V
Sbjct: 3553 DAGLYTCLAESPAGAIE-----------KSFRVRVQAPPNIVGPRGPRFVVGLAPGQL-V 3600
Query: 148 IACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVT 207
+ C + E+ P ++ + L+ LQ+ S D G Y C A N
Sbjct: 3601 LECSV-EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA- 3658
Query: 208 QEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKD 267
+S RV T R P + V+ Q+ +L C A G+P P V+W KD
Sbjct: 3659 -----GSTSVAFRVEIHTVPTIRSGPP----AVNVSVNQTALLPCQADGVPAPLVSWRKD 3709
Query: 268 GSSVTGYNKTRFLL--SNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEV 325
+ + +L +L I +D+G Y C+A N G +++V EPP +
Sbjct: 3710 RVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQG---RDLRVLEPPAI 3766
Query: 326 TMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLI-----SSQRLRLSRRALRVLS 380
S L + A L CE G+P P V+W ++ L + RL L AL + +
Sbjct: 3767 APSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRL-LPSNALLLTA 3825
Query: 381 MGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQ 440
GP+D ++C+ NEVG AH + Q+ P P + D T T + P
Sbjct: 3826 PGPQDSAQFECVVSNEVGEAHRLYQVTVHVP---PTIADDQTDFTVT-------MMAPVV 3875
Query: 441 MLRGQPALPRPPTSVGPASPQCPGEKGQG 469
+ +P P S A Q G +G G
Sbjct: 3876 LTCHSTGIPAPTVSWSKAGAQL-GARGSG 3903
Score = 107 bits (267), Expect = 6e-23
Identities = 114/446 (25%), Positives = 172/446 (38%), Gaps = 51/446 (11%)
Query: 50 GGTVILGC-VVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVA 108
G T L C V P+ +TW +G+ L DA + L + N + G Y C+A
Sbjct: 2460 GQTAHLMCNVTGHPQPKLTWFKDGRPL-ARGDAHHISPDGVLLQVLQANLSSAGHYSCIA 2518
Query: 109 RMPAGA------VASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVR 162
G ++ + A L +D + V N + C + P +
Sbjct: 2519 ANAVGEKTKHFQLSVLLAPTILGGAED---SADEEVTVTVNNPISLICEAL-AFPSPNIT 2574
Query: 163 YSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVR 222
+ EASR L+ + LQI+NA +ED G Y C N + + VK +
Sbjct: 2575 WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 2634
Query: 223 RSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLS 282
S + + E +T + +L LEC + +PPP + W KDG VT ++ + L
Sbjct: 2635 ISKDDPLGEVGVKEVKTKV---NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGE 2691
Query: 283 N--LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPP--------EVTMEL--- 329
L I T DSG Y C+A N G+ +NV + PP E+
Sbjct: 2692 GRLLQIQPTQVSDSGRYLCVATNVAGEDDQD---FNVLIQVPPMFQKVGDFSAAFEILSR 2748
Query: 330 ---------SQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSR--RALRV 378
I A L C+ PPP + W R PL + + + + R L++
Sbjct: 2749 EEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQI 2808
Query: 379 LSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSI----TPRLWQDAEL-ATGTPPVSPS 433
+ E+ G Y C A NEVG +L P + T L ++ + A+ T +
Sbjct: 2809 PLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCP 2868
Query: 434 KLGNP----EQMLRGQPALPRPPTSV 455
LGNP + G P P P V
Sbjct: 2869 ALGNPVPTISWLQNGLPFSPSPRLQV 2894
Score = 105 bits (261), Expect = 3e-22
Identities = 104/411 (25%), Positives = 162/411 (39%), Gaps = 35/411 (8%)
Query: 52 TVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARM 110
+V L C V P VTW + + L+ ++ + TH TL + G Y C A
Sbjct: 2954 SVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH-TLQLGRARLSDSGMYTCEALN 3012
Query: 111 PAGAVASVPATVTLAN--LQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQE 168
AG + L + Q + V G+ AV++C ++ P+ V + +
Sbjct: 3013 AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET-DALPEPTVTWYKDGQ 3071
Query: 169 WLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEA 228
L ++ + L+I A D+G+Y C N + V+T T +
Sbjct: 3072 PLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTF---------TLTVQV 3122
Query: 229 ARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKD-----GSSVTGYNKTRFLLSN 283
P+ +T+ G L+L C SG+P P VTW KD S+V G
Sbjct: 3123 PPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRG---GR 3179
Query: 284 LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTME--LSQLVIPWGQSAK 341
L + +GTY C+A+N + + V V P + + + GQ +
Sbjct: 3180 LQLSRLQPAQAGTYTCVAENTQAEARKDFV---VAVLVAPRIRSSGVAREHHVLEGQEVR 3236
Query: 342 LTCEVRGNPPPSVLWLRNAVPLISSQ----RLRLSRRALRVLSMGPEDEGVYQCMAENEV 397
L CE G PPP V WL++ PL R L +L + + D G Y C+A N
Sbjct: 3237 LDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPA 3296
Query: 398 GSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPAL 448
G +L T + P + Q A+ +GT P +L +RG P +
Sbjct: 3297 GED---ARLHTVNVLVPPTIKQGAD-GSGTLVSRPGELVTMVCPVRGSPPI 3343
Score = 104 bits (259), Expect = 5e-22
Identities = 101/375 (26%), Positives = 154/375 (41%), Gaps = 26/375 (6%)
Query: 50 GGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVA 108
G +L C + P VTW +G+ L + L L I G Y C
Sbjct: 3047 GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQA-LRGGQRLEIQEAQVSDKGLYSCKV 3105
Query: 109 RMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQE 168
AG T+T+ F+ + G+ V+ C + P V + +
Sbjct: 3106 SNVAGEAVRT-FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAPTVTWLKDRM 3163
Query: 169 WLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEA 228
+E+S + ++ G LQ+ G Y C A N + K + + R ++
Sbjct: 3164 PVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGV 3223
Query: 229 ARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNK---TRFLLS--N 283
AR + V +GQ + L+C A G PPP V W KDGS + G + RF L +
Sbjct: 3224 AREHH--------VLEGQEVRLDCEADGQPPPDVAWLKDGSPL-GQDMGPHLRFYLDGGS 3274
Query: 284 LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELS---QLVIPWGQSA 340
L++ D+G Y C+A N G+ L+ V V PP + LV G+
Sbjct: 3275 LVLKGLRASDAGAYTCVAHNPAGEDAR---LHTVNVLVPPTIKQGADGSGTLVSRPGELV 3331
Query: 341 KLTCEVRGNPPPSVLWLRNAVPLISSQRLRL--SRRALRVLSMGPEDEGVYQCMAENEVG 398
+ C VRG+PP V WL++ +PL SQR L S LR+ + D G++ C+A + G
Sbjct: 3332 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG 3391
Query: 399 SAHAVVQLRTSRPSI 413
A L+ P +
Sbjct: 3392 VADRNFTLQVQVPPV 3406
Score = 103 bits (258), Expect = 7e-22
Identities = 110/398 (27%), Positives = 158/398 (39%), Gaps = 82/398 (20%)
Query: 19 ACLLLATAGC-FADLNEVPQVT--VQPAST--VQKPGGTVILGCVVEP-PRMNVTWRLNG 72
+C+ TAG D+ V QV + P +T + G L CV P +TW
Sbjct: 954 SCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKET 1013
Query: 73 KELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKL 132
L V GTL+I + G Y C A G + Q+ +L
Sbjct: 1014 NALTSRGPHYNVS-KEGTLLIAQPSAQDAGAYVCTATNTVGFSS-----------QEMRL 1061
Query: 133 DVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQ 192
V + K W E Y ++PSG+L++
Sbjct: 1062 SVNRLA-------------------------LSKYVWEE-----YGLLPSGSLRLAQVQV 1091
Query: 193 EDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQ----TIIVTKGQSL 248
D G Y+C A NP +GS+ V + PP+ Q + V G++L
Sbjct: 1092 GDSGHYECTASNP-------AGSASHRYV-------LGVQVPPQVQPGPRVLKVLVGEAL 1137
Query: 249 ILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQP 308
L CVA G P P+++W+KDG + G R ++ D+G YRC A N G
Sbjct: 1138 DLNCVAEGNPEPQLSWSKDGVVLQG----RGPQGSVHFAAIRTSDAGRYRCEASNSAGVD 1193
Query: 309 GAAVILYNVQVFEPP----EVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLR--NAVP 362
V ++V EPP + T L + V G++A L C RG P P V W + ++ P
Sbjct: 1194 AWEV---ELRVLEPPHWGADETSGLLERVA--GENASLPCPARGTPKPQVTWRKGPSSEP 1248
Query: 363 LISSQRLR-LSRRALRVLSMGPEDEGVYQCMAENEVGS 399
L + L +L + S+ P D G Y+C A NEVGS
Sbjct: 1249 LHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 1286
Score = 102 bits (254), Expect = 2e-21
Identities = 112/417 (26%), Positives = 160/417 (38%), Gaps = 64/417 (15%)
Query: 40 VQPASTVQKP--GGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITAL 96
VQP V K G + L CV E P ++W +G L G G++ A+
Sbjct: 1122 VQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGP-------QGSVHFAAI 1174
Query: 97 NNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESH 156
GRY+C A AG A L + ++E G A + C
Sbjct: 1175 RTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPA-RGT 1233
Query: 157 PKAQV--RYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSG 214
PK QV R E L G ++ G+L + + S D G Y+C A N V G
Sbjct: 1234 PKPQVTWRKGPSSEPLHGQPG-VAVLEEGSLFLASVSPADSGDYECQATNEV-------G 1285
Query: 215 SSDRLRVRRSTAEAARIIYPPEA-------QTIIVTKGQSLILECVASGIPPPRVTWAKD 267
S+ R A ++Y P + + GQSL LEC A+G P P + W KD
Sbjct: 1286 STSR--------RAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKD 1337
Query: 268 GSSV-----------------TGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGA 310
V G ++ +L E DSG Y C A+N Q G
Sbjct: 1338 AQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAEN---QAGT 1394
Query: 311 AVILYNVQVFEPPEV--TMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISS-- 366
A +++ V PP V +++ G +L C G P P V W ++ P++
Sbjct: 1395 AQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGP 1454
Query: 367 -QRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAE 422
+++ + LR+ DEG YQC+A + G QLR P P +W E
Sbjct: 1455 HLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP---PTIWGSNE 1508
Score = 102 bits (253), Expect = 3e-21
Identities = 127/524 (24%), Positives = 187/524 (35%), Gaps = 93/524 (17%)
Query: 32 LNEVPQVTVQPASTVQKPGGTVILGC-VVEPPRMNVTWRLN-----GKELNGSDDALGVL 85
+ PQ+T P + G + +L C P VTWR G L +
Sbjct: 782 VGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQ 841
Query: 86 ITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNT 145
G L ++ Y C AR G V + + + + V EG
Sbjct: 842 PDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQP 901
Query: 146 AVIACHLPESHPKAQVRYSVKQEWLEASR-----GNYLIMPSGNLQIVNASQEDEGMYKC 200
+ C + P + + WL+ R + I G+L + A QE G Y C
Sbjct: 902 VSLPCIVLAGRPLPE------RHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSC 955
Query: 201 AAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPP 260
A N T+GS R V RI P A I +G L CVASG+P P
Sbjct: 956 VATN-------TAGSQHR-DVELVVQVPPRI--HPTATHHITNEGVPASLPCVASGVPAP 1005
Query: 261 RVTWAKDGSSVTG----YNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVG---------- 306
+TW K+ +++T YN ++ LLI S +D+G Y C A N VG
Sbjct: 1006 TITWTKETNALTSRGPHYNVSK--EGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 1063
Query: 307 ---------------QPGAAVILYNVQVFE-------------------------PPEVT 326
P ++ L VQV + PP+V
Sbjct: 1064 NRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQ 1123
Query: 327 MELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDE 386
L + G++ L C GNP P + W ++ V L + R + ++ ++ D
Sbjct: 1124 PGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVL----QGRGPQGSVHFAAIRTSDA 1179
Query: 387 GVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQP 446
G Y+C A N G V+LR + P W E + V+ P RG P
Sbjct: 1180 GRYRCEASNSAGVDAWEVELRV----LEPPHWGADETSGLLERVAGENASLP-CPARGTP 1234
Query: 447 ALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYE 490
P+ GP+S G+ G E + L+S + + YE
Sbjct: 1235 K-PQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYE 1277
Score = 100 bits (248), Expect = 1e-20
Identities = 95/380 (25%), Positives = 149/380 (39%), Gaps = 42/380 (11%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVAS---V 118
P N+TW +G S + + THG ++ A G+Y CV G V
Sbjct: 2569 PSPNITWMKDGAPFEASRNIQLLPGTHGLQILNA-QKEDAGQYTCVVTNELGEAVKNYHV 2627
Query: 119 PATVTLANLQDFKLDVQHVIEVDE--GNTAVIACHLPESHPKAQVRYSVKQEWLEASRGN 176
+ + +D L V EV +T + C P Y Q +SR
Sbjct: 2628 EVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSR-- 2685
Query: 177 YLIMPSGNLQIVNASQ-EDEGMYKCAAYN----------------PVTQEVKTSGSSDRL 219
++ G L + +Q D G Y C A N P+ Q+V ++ +
Sbjct: 2686 LQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEI 2745
Query: 220 RVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRF 279
R A Y + + L C + IPPP +TW ++ ++ ++
Sbjct: 2746 LSREEEARGGVTEYRE------IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV 2799
Query: 280 LLSN--LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLV---- 333
L L I E++G Y C A N VG+ + Y + V PP + + +LV
Sbjct: 2800 LQGGRVLQIPLVRAENAGRYSCKASNEVGEDW---LHYELLVLTPPVILGDTEELVEEVT 2856
Query: 334 IPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL--SRRALRVLSMGPEDEGVYQC 391
+ + L C GNP P++ WL+N +P S RL++ + L+V + D Y C
Sbjct: 2857 VNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMC 2916
Query: 392 MAENEVGSAHAVVQLRTSRP 411
+AEN+ GSA + LR P
Sbjct: 2917 VAENQAGSAEKLFTLRVQVP 2936
Score = 96.3 bits (238), Expect = 1e-19
Identities = 82/283 (28%), Positives = 124/283 (43%), Gaps = 33/283 (11%)
Query: 185 LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTK 244
LQI DEG+Y CAA N +G S R A +++ PP + V K
Sbjct: 1850 LQIEKVDLRDEGIYTCAATN-------LAGESKR-------EVALKVLVPPNIEPGPVNK 1895
Query: 245 G----QSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN--LLIDTTSEEDSGTYR 298
S+ LEC+ASG+PPP V+W K V+ + + L I+ D+G+YR
Sbjct: 1896 AVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYR 1955
Query: 299 CMADNGVGQPGAAVILYNVQVFEPPEVTMELS-QLVIPWGQSAKLTCEVRGNPPPSVLWL 357
C+A N G+ + Y ++V PP +T+ S + +LTC G P P+++WL
Sbjct: 1956 CVASN---VAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWL 2012
Query: 358 RNAVPLISSQRLRL----SRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSR-PS 412
++ P+ + L R L + S D G Y C+A + VG V L+ PS
Sbjct: 2013 KDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS 2072
Query: 413 ITPRLWQDAELATGTPPVSPSKLGNPEQMLR----GQPALPRP 451
I + +A + + P +L G+P PRP
Sbjct: 2073 ILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRP 2115
Score = 96.3 bits (238), Expect = 1e-19
Identities = 139/557 (24%), Positives = 205/557 (36%), Gaps = 81/557 (14%)
Query: 46 VQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDDALGVLITHG---TLVITALNNHTV 101
V +PG V + C V P ++V+W +G L S L HG TL I+ +
Sbjct: 3324 VSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTL----LHGSGHTLRISKVQLADA 3379
Query: 102 GRYQCVARMPAGAVASVPATVTLANLQDFKLDVQ--HVIEVDE--GNTAVIACHLPESHP 157
G + CVA PAG ++F L VQ V+E E + V+ L E
Sbjct: 3380 GIFTCVAASPAGVAD-----------RNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPC 3428
Query: 158 KAQVRYSVKQEWLEASRGNYLIMPS----GNLQIVNASQEDEGMYKCAAYNPVTQEVKTS 213
+A+ W++ G L+ S +LQ+ D G Y C A V +
Sbjct: 3429 EARGVPLPLVSWMKD--GEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVA-------VSEA 3479
Query: 214 GSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTG 273
G + R + + E I + + +T G + L C A G P P +TW KDG ++T
Sbjct: 3480 GEARR-HFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTR 3538
Query: 274 YNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLV 333
L + D+G Y C+A++ GA + V+V PP +
Sbjct: 3539 LENNSRATRVLRV-----RDAGLYTCLAES---PAGAIEKSFRVRVQAPPNIVGPRGPRF 3590
Query: 334 IPW---GQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRA--LRVLSMGPEDEGV 388
+ GQ L C V P P + W R+ + L + R L++ ++ D G
Sbjct: 3591 VVGLAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGD 3649
Query: 389 YQCMAENEVGSA--------HAVVQLRTSRPSITPRLWQDAEL---ATGTP--------- 428
Y C A N GS H V +R+ P++ + Q A L A G P
Sbjct: 3650 YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 3709
Query: 429 -----PVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAP---AEAPIILSS 480
P SP PE LR QP L + + G QG E P I S
Sbjct: 3710 RVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPS 3769
Query: 481 PRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLD 540
P ++ P P++ + +K+ +P+N L LT
Sbjct: 3770 PSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSN--ALLLTAPG 3827
Query: 541 PGSLYEVEMAAYNCAGE 557
P + E N GE
Sbjct: 3828 PQDSAQFECVVSNEVGE 3844
Score = 95.5 bits (236), Expect = 2e-19
Identities = 93/395 (23%), Positives = 158/395 (40%), Gaps = 64/395 (16%)
Query: 36 PQVTVQPASTVQKPGGTVILGCVVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITA 95
P+ S VQ T+ +PP VTW +G+ + G++ L + +L +
Sbjct: 2261 PREPPTQVSVVQDGVATLECNATGKPPP-TVTWERDGQPV-GAELGLQLQNQGQSLHVER 2318
Query: 96 LNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDV----QHVIEVDEGNTAVIACH 151
GRY CVA AG + F+L V + + ++D A H
Sbjct: 2319 AQAAHTGRYSCVAENLAGRAE-----------RKFELSVLVPPELIGDLDPLTNITAALH 2367
Query: 152 LPESH-------PKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYN 204
P + P +R+ +E + YL+ L++ ++D G+Y C A N
Sbjct: 2368 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASN 2427
Query: 205 PVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQT------IIVTKGQSLILECVASGIP 258
+ RR+ + ++ PP + I V GQ+ L C +G P
Sbjct: 2428 EAGE------------ARRNFS--VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHP 2473
Query: 259 PPRVTWAKDGSSVTGYNKTRFLLSNLLIDT--TSEEDSGTYRCMADNGVGQPG------- 309
P++TW KDG + + +L+ + +G Y C+A N VG+
Sbjct: 2474 QPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSV 2533
Query: 310 --AAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQ 367
A IL + EVT+ ++ + L CE P P++ W+++ P +S+
Sbjct: 2534 LLAPTILGGAEDSADEEVTVTVNNPI-------SLICEALAFPSPNITWMKDGAPFEASR 2586
Query: 368 RLRL--SRRALRVLSMGPEDEGVYQCMAENEVGSA 400
++L L++L+ ED G Y C+ NE+G A
Sbjct: 2587 NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEA 2621
Score = 93.2 bits (230), Expect = 1e-18
Identities = 70/242 (28%), Positives = 111/242 (45%), Gaps = 25/242 (10%)
Query: 182 SGNL--QIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPE--- 236
SGN +I+ AS+ +EG Y+C A + R R+ A+ PP+
Sbjct: 476 SGNSSWEILRASKAEEGTYECTAVS-------------RAGTGRAKAQIVVTDPPPQLVP 522
Query: 237 AQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTS--EEDS 294
A + V+ G++ +L C G P +TW +D + L++L ++ + D
Sbjct: 523 APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDG 582
Query: 295 GTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSV 354
G Y+C+A N G A+V L V E P+V++ S G K++C G P P +
Sbjct: 583 GRYQCVASNANGVTRASVWLL---VREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI 639
Query: 355 LWLRNAVPLISSQRLRL-SRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQL-RTSRPS 412
W R + L R+ + ++ L + + PED G Y C A NEVG+ V L T PS
Sbjct: 640 SWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 699
Query: 413 IT 414
++
Sbjct: 700 VS 701
Score = 92.8 bits (229), Expect = 2e-18
Identities = 92/356 (25%), Positives = 139/356 (39%), Gaps = 56/356 (15%)
Query: 85 LITHGTLVITALNNHTVGRYQCVARMPAGAVA-------SVPATVTLANLQDFKLDVQHV 137
L+ G+L + + G Y+C A PAG+ + VP V V
Sbjct: 1078 LLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPG---------PRV 1128
Query: 138 IEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGM 197
++V G + C + E +P+ Q+ +S K + RG P G++ D G
Sbjct: 1129 LKVLVGEALDLNC-VAEGNPEPQLSWS-KDGVVLQGRG-----PQGSVHFAAIRTSDAGR 1181
Query: 198 YKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGI 257
Y+C A N S D V E + + G++ L C A G
Sbjct: 1182 YRCEASN--------SAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGT 1233
Query: 258 PPPRVTWAKDGSSVTGYNKTRFLL---SNLLIDTTSEEDSGTYRCMADNGVGQPGAAVIL 314
P P+VTW K SS + + + +L + + S DSG Y C A N VG L
Sbjct: 1234 PKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKL 1293
Query: 315 YNVQVFEPPEVTMELSQLVIPW--GQSAKLTCEVRGNPPPSVLWLRNA----VPL----- 363
V+ PP + + + + GQS L C+ G P P ++WL++A VPL
Sbjct: 1294 V---VYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGY 1350
Query: 364 --------ISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRP 411
+ RL ++L + D G+Y C AEN+ G+A L P
Sbjct: 1351 GWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTP 1406
Score = 92.0 bits (227), Expect = 3e-18
Identities = 143/578 (24%), Positives = 215/578 (37%), Gaps = 91/578 (15%)
Query: 48 KPGGTVILGC---VVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRY 104
K T+ L C V PP + W +G+ + S L VL L I GRY
Sbjct: 2652 KVNSTLTLECESWAVPPP--TIRWYKDGQPVTPSS-RLQVLGEGRLLQIQPTQVSDSGRY 2708
Query: 105 QCVARMPAG-------AVASVP-----------ATVTLANLQDFKLDVQHVIEVDEGNTA 146
CVA AG + VP A L+ ++ + V E+ E N A
Sbjct: 2709 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 2768
Query: 147 VIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGN--LQIVNASQEDEGMYKCAAYN 204
+ C P Y Q S G+ + + G LQI E+ G Y C A N
Sbjct: 2769 YLYCDTNAIPPPDLTWYREDQP---LSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASN 2825
Query: 205 PVTQEVKTSGSSDRLRVRRSTAEAARIIYPPE--AQTIIVTKGQSLILECVASGIPPPRV 262
V + D L I+ E + + V ++ L+C A G P P +
Sbjct: 2826 EVGE--------DWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTI 2877
Query: 263 TWAKDGSSVTGYNKTRFLLSNLLIDTTSEE--DSGTYRCMADNGVGQPGAAVILYNVQVF 320
+W ++G + + + L ++ ++ E D+ +Y C+A+N Q G+A L+ ++V
Sbjct: 2878 SWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAEN---QAGSAEKLFTLRVQ 2934
Query: 321 EPPEVT-MELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL--SRRALR 377
PP + ++L Q+ S L C+V +P P V W +++ L + + L L+
Sbjct: 2935 VPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQ 2994
Query: 378 VLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSI---TPRLWQDAEL----------- 423
+ D G+Y C A N G +VQL P PR QDA L
Sbjct: 2995 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSC 3054
Query: 424 ---ATGTPPVSPSKLGNP------EQMLRGQPALPRPPTSV---GPASPQCPGEKGQGA- 470
A P V+ K G P Q LRG L V G S + G+
Sbjct: 3055 ETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVR 3114
Query: 471 ----PAEAPIILSSPRT---SKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWT 523
+ P +P+T S+ LV G + + +K R SS
Sbjct: 3115 TFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTW--LKDRMPVESS---A 3169
Query: 524 ISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTA 561
+ G+ + RL L+RL P + Y C E A
Sbjct: 3170 VHGVVSRGGRLQLSRLQP-----AQAGTYTCVAENTQA 3202
Score = 89.4 bits (220), Expect = 2e-17
Identities = 114/406 (28%), Positives = 167/406 (41%), Gaps = 49/406 (12%)
Query: 36 PQVTVQPASTVQKPGGTVILGCV---VEPPRMNVTWRLNGKELNGSDDALGVLITHGTLV 92
P V+ A + G +L C V PPR V W G E+ + + + G L
Sbjct: 698 PSVSAVNAVVLVAVGEEAVLVCEASGVPPPR--VIWYRGGLEMILAPEGS----SSGKLR 751
Query: 93 ITALNNHTVGRYQCVARMPAG-AVASVPATVTLA-NLQDFKLDVQHVIEVDEGNTAVIAC 150
I A G Y C A G A A + V A L + DV V+ G +A++AC
Sbjct: 752 IPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVT----VELGRSALLAC 807
Query: 151 HLPESHPKAQV-RYSVKQEW---LEASRGNYLIMP-SGNLQIVNASQEDEGMYKCAAYNP 205
P R Q L A RG+ P SG L + + ED+ Y C A N
Sbjct: 808 RATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN- 866
Query: 206 VTQEVKTSGSSDRLRVRRSTAEAARIIY---PPE----AQTIIVTKGQSLILECVA-SGI 257
V +V+ AEA I+ PP+ A T+ V +GQ + L C+ +G
Sbjct: 867 VFGKVQ--------------AEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGR 912
Query: 258 PPPRVTWAKDGSSVT-GYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYN 316
P P W KDG + G + +L +D +E +G Y C+A N G V L
Sbjct: 913 PLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELV- 971
Query: 317 VQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLIS-SQRLRLSRRA 375
VQV PP + + + G A L C G P P++ W + L S +S+
Sbjct: 972 VQV--PPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG 1029
Query: 376 -LRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQD 420
L + +D G Y C A N VG + ++L +R +++ +W++
Sbjct: 1030 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEE 1075
Score = 84.7 bits (208), Expect = 4e-16
Identities = 111/455 (24%), Positives = 172/455 (37%), Gaps = 51/455 (11%)
Query: 32 LNEVPQVTVQPASTVQKPGGTVI-----LGC-VVEPPRMNVTWRLNGKELNGSDDALGVL 85
+N P++T+ P+ PG ++ L C P + W +G ++ + G+
Sbjct: 1973 VNVPPRITLPPSL----PGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTP-GLQ 2027
Query: 86 ITHGTLVITALNNHTV--GRYQCVARMPAGAVASVPATVTL-ANLQDFKLDVQHVIEVDE 142
+ G V+T + GRY CVA AV V L ++ L + + V
Sbjct: 2028 VFPGGRVLTLASARASDSGRYSCVA---VSAVGEDRQDVVLQVHMPPSILGEELNVSVVA 2084
Query: 143 GNTAVIACHLPESH--PKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKC 200
+ + C +SH P + + LE G +L LQ+ A D G Y C
Sbjct: 2085 NESVALEC---QSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTC 2141
Query: 201 AAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPP 260
A N K + A + E+ T+ V +G L C G+P P
Sbjct: 2142 EALNQAGHSEKHYNLN---------VWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFP 2192
Query: 261 RVTWAKDGSSVTGYNKTRFLLSN----LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYN 316
+++W KDG + G +S L + GTY C N VG +
Sbjct: 2193 KISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDL---Q 2249
Query: 317 VQVFEPPEVT---MELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSR 373
++V PP++ +Q+ + A L C G PPP+V W R+ P+ + L+L
Sbjct: 2250 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQN 2309
Query: 374 --RALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVS 431
++L V G Y C+AEN G A +L P P L D + T
Sbjct: 2310 QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVP---PELIGDLDPLTNI---- 2362
Query: 432 PSKLGNPEQMLRGQPALPRPPTS-VGPASPQCPGE 465
+ L +P +L +P P P PGE
Sbjct: 2363 TAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGE 2397
Score = 60.5 bits (145), Expect = 9e-09
Identities = 57/203 (28%), Positives = 86/203 (42%), Gaps = 15/203 (7%)
Query: 4 GTMTAWRGMRPEVTLACLLLATAGCFADLNEVPQVTVQPASTVQKP-GGTVILGCVVE-P 61
GT W R T A F + E P + + S + +P GG++ L CVV
Sbjct: 4193 GTYVCWAENRVGRTQAV-------SFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD 4245
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPAT 121
P ++ W +G L GS L + +G+L I GRYQC+A G VA
Sbjct: 4246 PVPDIHWIKDGLPLRGSH--LRHQLQNGSLTIHRTERDDAGRYQCLAENEMG-VAKKVVI 4302
Query: 122 VTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMP 181
+ L + F+++ Q + V G+ + C P + + + L ASR +P
Sbjct: 4303 LVLQSAPVFQVEPQDMT-VRSGDDVALRCQAT-GEPTPTIEWLQAGQPLRASR-RLRTLP 4359
Query: 182 SGNLQIVNASQEDEGMYKCAAYN 204
G+L + N D G Y C A+N
Sbjct: 4360 DGSLWLENVETGDAGTYDCVAHN 4382
Score = 56.6 bits (135), Expect = 1e-07
Identities = 68/293 (23%), Positives = 113/293 (38%), Gaps = 40/293 (13%)
Query: 35 VPQVTVQPASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDDALGVLITHG--TL 91
+P T P + G + L C P + W +N + + GV G TL
Sbjct: 4128 LPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTE-----GVSEQDGGSTL 4182
Query: 92 VITALNNHTVGRYQCVARMPAGAVASVPAT----VTLANLQDFKLDVQHVIEVDEGNTAV 147
A++ G Y C A G +V + + F V+ V + + V
Sbjct: 4183 QRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV 4242
Query: 148 IACHLPESHPKAQVRYSVKQEWLEAS---RGNYLI--MPSGNLQIVNASQEDEGMYKCAA 202
+P+ H W++ RG++L + +G+L I ++D G Y+C A
Sbjct: 4243 RGDPVPDIH------------WIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLA 4290
Query: 203 YNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRV 262
N + K + V +S ++ E Q + V G + L C A+G P P +
Sbjct: 4291 ENEMGVAKKVV-----ILVLQSAP-----VFQVEPQDMTVRSGDDVALRCQATGEPTPTI 4340
Query: 263 TWAKDGSSVTGYNKTRFLLS-NLLIDTTSEEDSGTYRCMADNGVGQPGAAVIL 314
W + G + + R L +L ++ D+GTY C+A N +G A L
Sbjct: 4341 EWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFL 4393
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 137 bits (345), Expect = 6e-32
Identities = 107/388 (27%), Positives = 166/388 (42%), Gaps = 21/388 (5%)
Query: 34 EVPQVTVQPASTVQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLV 92
E P++T +P G TV C E P+ + W N EL+ D+ L+ GTL+
Sbjct: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM 303
Query: 93 ITALNNHTVGRYQCVARMPAGAVASVPATVTLAN---LQDFKLDVQHVIEVDEGNTAVIA 149
I G YQC+A+ AG V + T+ F + Q+ EV G + +
Sbjct: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNT-EVLVGESVTLE 362
Query: 150 CHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQE 209
C HP ++ ++ I PSG L I N Q D G Y C+A N +
Sbjct: 363 CS-ATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNI--- 418
Query: 210 VKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGS 269
D + A + Q +V +GQ++ +C A G PPP + W K GS
Sbjct: 419 -------DSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGS 471
Query: 270 SVTGYNKTRFLLSN--LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTM 327
++ ++ +LS+ L I + D G Y C A N +G L VQ P
Sbjct: 472 QLS-VDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHL-TVQPRVTPVFAS 529
Query: 328 ELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRA-LRVLSMGPEDE 386
S + G + +L C +G P P++ W ++ V + S + +S L + +GP D
Sbjct: 530 IPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADA 589
Query: 387 GVYQCMAENEVGSAHAVVQLRTSRPSIT 414
G Y+C+A N +GSA + L + P ++
Sbjct: 590 GRYECVARNTIGSASVSMVLSVNVPDVS 617
Score = 129 bits (324), Expect = 2e-29
Identities = 97/309 (31%), Positives = 144/309 (46%), Gaps = 19/309 (6%)
Query: 139 EVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYL-IMPSGNLQIVNASQEDEGM 197
+V GNT C E +PK ++ + L + L ++ G L I N + D+G+
Sbjct: 256 DVTSGNTVYFTCRA-EGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGI 314
Query: 198 YKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGI 257
Y+C A N V EVKT + LR S A +I P + ++ G+S+ LEC A+G
Sbjct: 315 YQCMAKN-VAGEVKTQEVT--LRYFGSPARPTFVIQPQNTEVLV---GESVTLECSATGH 368
Query: 258 PPPRVTWAK-DGSSVTGYNKTRFLLS-NLLIDTTSEEDSGTYRCMADNGVGQPGAAVILY 315
PPPR++W + D + + + S L I + DSG Y C A N + A +
Sbjct: 369 PPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFII 428
Query: 316 NVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPL-ISSQRLRLSRR 374
VQ P+ T+ V+ GQ+ CE +GNPPP + W + L + + L LS
Sbjct: 429 -VQAL--PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSG 485
Query: 375 ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITP---RLWQDAELATGTPPVS 431
LR+ + D+G Y+C A N +GS V L T +P +TP + D + G
Sbjct: 486 TLRISGVALHDQGQYECQAVNIIGSQKVVAHL-TVQPRVTPVFASIPSDTTVEVGANVQL 544
Query: 432 P-SKLGNPE 439
P S G PE
Sbjct: 545 PCSSQGEPE 553
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 135 bits (341), Expect = 2e-31
Identities = 94/355 (26%), Positives = 155/355 (43%), Gaps = 18/355 (5%)
Query: 53 VILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMP 111
V L C V+ P+ ++ W+LNG +++ D ++ L+ G YQC A
Sbjct: 46 VKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNS 105
Query: 112 AGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLE 171
G + S A + A L +FK + + V G V+ C P + + +
Sbjct: 106 FGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSY 165
Query: 172 ASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARI 231
++ +GNL I + D G Y C N VT K G L +R
Sbjct: 166 QDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNH-KVLGPPTPLILRNDGVMGE-- 222
Query: 232 IYPPEAQ-----TIIVTKGQSLILECVASGIPPPRVTWAK-DGSSVTGYNKTRFLLSN-- 283
Y P+ + T+ KG ++ LEC A G P P + W + DG + K R SN
Sbjct: 223 -YEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIA--RKARRHKSNGI 279
Query: 284 LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLT 343
L I +ED+G Y C+A+N G+ V + + P +++ + + ++
Sbjct: 280 LEIPNFQQEDAGLYECVAENSRGKN---VARGQLTFYAQPNWIQKINDIHVAMEENVFWE 336
Query: 344 CEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVG 398
C+ G P P+ WL+N PL++ R+++ + L + + D G+YQC+AEN+ G
Sbjct: 337 CKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHG 391
Score = 93.2 bits (230), Expect = 1e-18
Identities = 146/582 (25%), Positives = 223/582 (38%), Gaps = 93/582 (15%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPAT 121
P+ W NG+ L D + I GTL IT +N G YQC+A G + S
Sbjct: 343 PKPTYKWLKNGEPLLTRDR---IQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAEL 399
Query: 122 VTLANLQDFKLDV-QHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIM 180
+A DF + + V V G VI C P++ PK + ++ L+ + I
Sbjct: 400 SVIAVGPDFSRTLLKRVTLVKVGGEVVIECK-PKASPKPVYTWKKGRDILKENE-RITIS 457
Query: 181 PSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTI 240
GNL+I+N ++ D G Y C A T T+ S+ L V+ T R++ PP +
Sbjct: 458 EDGNLRIINVTKSDAGSYTCIA----TNHFGTASSTGNLVVKDPT----RVMVPPSSMD- 508
Query: 241 IVTKGQSLILECVASGIPPPRV--TWAKDGSSV----TGYNKTRF----LLSNLLIDTTS 290
VT G+S++L C + + TW+ +G + G + R +L+I
Sbjct: 509 -VTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQ 567
Query: 291 EEDSGTYRCMADNGVGQPGAAVILY---------NVQVFEPPEVTMELSQLVIPWGQSAK 341
+ +G Y CM V + AA L V + E + T +LS P S
Sbjct: 568 LKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPI 627
Query: 342 LTCEVRGNPPPSVLWLR-NAVP-LISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVG- 398
++ P SV W + VP LI + + V+ + P E ++ +A N +G
Sbjct: 628 TMYVIQARTPFSVGWQAVSTVPELIDGKTFTAT-----VVGLNPWVEYEFRTVAANVIGI 682
Query: 399 --SAHAVVQLRTSR--PSITPR--------------LWQDA--ELATGTP---PVSPSKL 435
+ + RT P +TP W+ EL G V+
Sbjct: 683 GEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPY 742
Query: 436 GNPEQML-------------RGQPALPRPPTSV----------GPASPQCPGEKGQGAPA 472
G ML R + P P V GP SP + P
Sbjct: 743 GKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPT 802
Query: 473 EAPIILSSPRTSKTDSYELVW-RPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQ 531
+ P + + S TD E+ W P + GR I Y VK+ + + ++ NQ
Sbjct: 803 KPPASIFARSLSATD-IEVFWASPLEKNRGR--IQGYEVKYWRHEDKEENARKIRTVGNQ 859
Query: 532 HRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKP 573
+T L LY + + AYN AG G ++ T R+P P
Sbjct: 860 TSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPP 901
Score = 83.6 bits (205), Expect = 1e-15
Identities = 91/395 (23%), Positives = 157/395 (39%), Gaps = 25/395 (6%)
Query: 29 FADLNEVPQVTVQPASTVQKPGGTVILGCVVEPPRMNVTWRLNGKELNGSDDALGVLITH 88
FA L+ T S + G ++ G ++ W N + + D+ V
Sbjct: 118 FAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFN-EYPSYQDNRRFVSQET 176
Query: 89 GTLVITALNNHTVGRYQCVAR--MPAGAVASVPATVTLAN-----LQDFKLDVQ--HVIE 139
G L I + VG Y CV + V P + L N + K++VQ +
Sbjct: 177 GNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVP 236
Query: 140 VDEGNTAVIACH-LPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMY 198
+G T + C L P R + + +R + +G L+I N QED G+Y
Sbjct: 237 TAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRH---KSNGILEIPNFQQEDAGLY 293
Query: 199 KCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIP 258
+C A N + V R A+ + + I V +++ EC A+G P
Sbjct: 294 ECVAENSRGKNV----------ARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRP 343
Query: 259 PPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQ 318
P W K+G + ++ + L I + D+G Y+C+A+N G + L +
Sbjct: 344 KPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIA 403
Query: 319 VFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRA-LR 377
V T+ ++ G + C+ + +P P W + L ++R+ +S LR
Sbjct: 404 VGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLR 463
Query: 378 VLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPS 412
++++ D G Y C+A N G+A + L P+
Sbjct: 464 IINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPT 498
Score = 75.9 bits (185), Expect = 2e-13
Identities = 73/275 (26%), Positives = 119/275 (43%), Gaps = 39/275 (14%)
Query: 154 ESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQ-EDEGMYKCAAYNP----VTQ 208
+ +PK +R+ + ++ + G+L I N ++ +D G Y+C A N V++
Sbjct: 53 KGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSR 112
Query: 209 EVKTSGSS-DRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPR---VTW 264
E K + D + R + T+ V +GQ ++L C PPP +++
Sbjct: 113 EAKLQFAYLDNFKTRTRS-------------TVSVRRGQGMVLLCG----PPPHSGELSY 155
Query: 265 AKDGSSVTGYNKTRFLLS----NLLIDTTSEEDSGTYRCMADNGVGQ-----PGAAVILY 315
A + Y R +S NL I + D G Y C+ N V P +IL
Sbjct: 156 AWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILR 215
Query: 316 NVQVFEP--PEVTMELSQLV-IPWGQSAKLTCEVRGNPPPSVLWLR-NAVPLISSQRLRL 371
N V P++ ++ + V G + KL C GNP P+++W R + P+ R
Sbjct: 216 NDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHK 275
Query: 372 SRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQL 406
S L + + ED G+Y+C+AEN G A QL
Sbjct: 276 SNGILEIPNFQQEDAGLYECVAENSRGKNVARGQL 310
Score = 75.1 bits (183), Expect = 3e-13
Identities = 182/851 (21%), Positives = 302/851 (35%), Gaps = 175/851 (20%)
Query: 36 PQVTVQ-PASTVQKPGGTVILGC-VVEPPRMNVTWR-LNGKELNGSDDALGVLITHGTLV 92
P++ VQ P + G TV L C + P + WR +GK + ++G L
Sbjct: 225 PKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHK---SNGILE 281
Query: 93 ITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHL 152
I G Y+CVA G V L F + ++++ + A+
Sbjct: 282 IPNFQQEDAGLYECVAENSRGK------NVARGQLT-FYAQPNWIQKINDIHVAMEENVF 334
Query: 153 PESHPKAQVRYSVKQEWLEASRG----NYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQ 208
E KA R +WL+ + + + G L I + D GMY+C A N
Sbjct: 335 WEC--KANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAEN---- 388
Query: 209 EVKTSGSSDRLRVRRSTAEAARIIYPPE------AQTIIVTKGQSLILECVASGIPPPRV 262
+ V S AE + I P+ + +V G +++EC P P
Sbjct: 389 ---------KHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVY 439
Query: 263 TWAKDGSSVTGYNKTRFLLS---NLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQV 319
TW K G + N+ R +S NL I ++ D+G+Y C+A N G + N+ V
Sbjct: 440 TWKK-GRDILKENE-RITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTG---NLVV 494
Query: 320 FEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVL--WLRNAVPLISSQRL-------- 369
+P V + S + + G+S L C+V + ++ W N LI R
Sbjct: 495 KDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNG-HLIDFDRDGDHFERVG 553
Query: 370 -RLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTP 428
+ S L + ++ + G Y CM + V A L P P E+ T
Sbjct: 554 GQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTA 613
Query: 429 PVSPSKLGNPEQMLRGQPALPRPPTSVG-------------------------------- 456
+S + + R P SVG
Sbjct: 614 QLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFR 673
Query: 457 --------PASPQCPGEKG---QGAPAEAPIILSSPRTSKTDSYELVWR--PRHEGSGRA 503
P P EK + P P +S SK++ + W P +GR
Sbjct: 674 TVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELV-ITWETVPEELQNGRG 732
Query: 504 PILYYVVKHRKVTNSSDDWTI-SGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAM 562
YVV R T+ + A+++ + P S +EV++ +N GEG +
Sbjct: 733 --FGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSP 790
Query: 563 VTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSV 622
T ++ S E++ P + P + S T +
Sbjct: 791 TT----------VVYSAEEE----------------------PTKPPASIFARSLSATDI 818
Query: 623 YVTWI-PRGNGGFPIQSFRVEY----------KKLKKVGDWILATSAIPPSRLSVEITGL 671
V W P IQ + V+Y +K++ VG+ + S +IT L
Sbjct: 819 EVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGN-----------QTSTKITNL 867
Query: 672 EKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIML 731
+ Y V+A N G SA + + P + P +++ I+L
Sbjct: 868 KGSVLYHLAVKAYNSAGTGPSSAT--------VNVTTRKPPPSQPPGNIIWNSSDSKIIL 919
Query: 732 KWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQ 791
W + A +N + + G+ + YR + S ++E +K +S L + Y I+++
Sbjct: 920 NWDQVKALDNESEVKGYKVLYRWNRQSSTS-----VIETNKTSVELS-LPFDEDYIIEIK 973
Query: 792 CFNEGGESEFS 802
F++GG+ S
Sbjct: 974 PFSDGGDGSSS 984
Score = 62.0 bits (149), Expect = 3e-09
Identities = 46/219 (21%), Positives = 88/219 (40%), Gaps = 8/219 (3%)
Query: 605 PPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILAT--SAIPPS 662
PP P+ TI ++T+ ++W P + PI + ++ + VG ++T I
Sbjct: 596 PPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGK 655
Query: 663 RLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTD 722
+ + GL Y+FR A N++G EPS PS V V+G
Sbjct: 656 TFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSG------G 709
Query: 723 AVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQP 782
+++ +++ W +P N G+ + +RP + +Y + P
Sbjct: 710 GGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHP 769
Query: 783 ETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRL 821
+ +++K+ FN GE FS + + + + P +
Sbjct: 770 FSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASI 808
Score = 47.0 bits (110), Expect = 1e-04
Identities = 34/107 (31%), Positives = 46/107 (42%), Gaps = 13/107 (12%)
Query: 338 QSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGP---EDEGVYQCMAE 394
+ KL CEV+GNP P + W N + + R S +L P +D G YQC A
Sbjct: 44 KKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTAT 103
Query: 395 NEVG---SAHAVVQL-------RTSRPSITPRLWQDAELATGTPPVS 431
N G S A +Q +R +++ R Q L G PP S
Sbjct: 104 NSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHS 150
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 134 bits (337), Expect = 5e-31
Identities = 106/371 (28%), Positives = 168/371 (45%), Gaps = 24/371 (6%)
Query: 46 VQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRY 104
V KP + L C + P ++TW +G+ + + +++ G+L I + G Y
Sbjct: 4092 VDKP---ITLSCEADGLPPPDITWHKDGRAI--VESIRQRVLSSGSLQIAFVQPGDAGHY 4146
Query: 105 QCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYS 164
C+A AG+ S +T ++ + V+E + A++ C + + P + +
Sbjct: 4147 TCMAANVAGS--SSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPC-VADGIPTPAINWK 4203
Query: 165 VKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRS 224
L G Y P G L + N ED G Y C A N ++ T + + V +
Sbjct: 4204 KDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLT--VHVLPT 4261
Query: 225 TAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNL 284
E + + KG+ L L C A+GIP P++TW + + + + + S L
Sbjct: 4262 FTELPG--------DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSEL 4313
Query: 285 LIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMEL-SQLVIPWGQSAKLT 343
+I+ S+EDSGTY C A+N VG A +Y V EPP + S + P G +A L
Sbjct: 4314 VIERVSKEDSGTYVCTAENSVGFVKAIGFVY---VKEPPVFKGDYPSNWIEPLGGNAILN 4370
Query: 344 CEVRGNPPPSVLWLRNAVPLISSQRLR-LSRRALRVLSMGPEDEGVYQCMAENEVGSAHA 402
CEV+G+P P++ W R V + S R+R L +L + ED G Y C+A NE G
Sbjct: 4371 CEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVER 4430
Query: 403 VVQLRTSRPSI 413
+ L P I
Sbjct: 4431 SMSLTLQSPPI 4441
Score = 132 bits (332), Expect = 2e-30
Identities = 105/393 (26%), Positives = 181/393 (46%), Gaps = 31/393 (7%)
Query: 20 CLLLATAGC-----FADLNEVPQVTVQPASTVQKPGGTVILGC-VVEPPRMNVTWRLNGK 73
C+ +++AG F D++E P V P + PG +L C ++ N+TW+ N +
Sbjct: 499 CIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDR 558
Query: 74 ELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLD 133
++ ++ A + + +L + ++ + G Y C+ G+ A A+V L + K+
Sbjct: 559 DVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSA---ASVFLTVQEPPKVT 615
Query: 134 VQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQE 193
V + G + V +PK ++ ++V ++ S Y + G L I NA+ +
Sbjct: 616 VMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSH-RYRMTSDGTLFIKNAAPK 674
Query: 194 DEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECV 253
D G+Y C A N S +D+ EA +++ ++V G ++EC
Sbjct: 675 DAGIYGCLASN--------SAGTDKQNSTLRYIEAPKLMVVQSE--LLVALGDITVMECK 724
Query: 254 ASGIPPPRVTWAKDGSSV--TGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAA 311
SGIPPP+V W K + + + LL L I T + D+G Y C+A N G+
Sbjct: 725 TSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGK 784
Query: 312 VILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLR-NAVPLIS----- 365
+ L V PP E + + + G + L C V+G P P++ W R + +P+ S
Sbjct: 785 ITL---DVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSV 841
Query: 366 SQRLRLSRRALRVLSMGPEDEGVYQCMAENEVG 398
S +L AL +L++ D+G Y C AEN+ G
Sbjct: 842 SSISQLRTGALFILNLWASDKGTYICEAENQFG 874
Score = 122 bits (305), Expect = 2e-27
Identities = 109/401 (27%), Positives = 170/401 (42%), Gaps = 39/401 (9%)
Query: 32 LNEVPQVTVQPASTVQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGT 90
+N P + P S V + +L C+ E P +TWR +G L G+ +L +G
Sbjct: 3709 VNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSIL-ENGF 3767
Query: 91 LVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVI-- 148
L I + + GRY C+A AG T D ++ V I N VI
Sbjct: 3768 LHIQSAHVTDTGRYLCMATNAAG---------TDRRRIDLQVHVPPSIAPGPTNMTVIVN 3818
Query: 149 -----ACHLPESHPKAQVRYSVKQEWL--EASRGNYLIMPSGNLQIVNASQEDEGMYKCA 201
AC PK + + L + ++ +Y ++ SG+L I++ S +D Y+C
Sbjct: 3819 VQTTLACEAT-GIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECT 3877
Query: 202 AYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPR 261
T+G+ D R T + I E +VTK ++ C ASG+P P
Sbjct: 3878 V---------TNGAGDDKRTVDLTVQVPPSI-ADEPTDFLVTKHAPAVITCTASGVPFPS 3927
Query: 262 VTWAKDGSSVTGYNKTRFLLSNLLID--TTSEEDSGTYRCMADNGVGQPGAAVILYNVQV 319
+ W K+G + +LS+ I+ T +G Y C+A N G V L+ V
Sbjct: 3928 IHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLH---V 3984
Query: 320 FEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLR--LSRRALR 377
EPP + + S+L + L CE G P P + W + + + +S R L L+
Sbjct: 3985 HEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQ 4044
Query: 378 VLSMGPEDEGVYQCMAENEVGSAHAVVQLRTS-RPSITPRL 417
+ ED G Y C+A+N G+A ++L P I+P L
Sbjct: 4045 ISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHL 4085
Score = 117 bits (294), Expect = 5e-26
Identities = 110/421 (26%), Positives = 180/421 (42%), Gaps = 49/421 (11%)
Query: 58 VVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAG---- 113
V P + W +G +L D +L+ LVI G Y+C+A AG
Sbjct: 1758 VTGSPPPTIMWLKDG-QLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKK 1816
Query: 114 ---AVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWL 170
VP T+ + L + ++ V++ + C + P + + + +
Sbjct: 1817 EFEVTVHVPPTIKSSGLSE-RVVVKY-------KPVALQC-IANGIPNPSITWLKDDQPV 1867
Query: 171 EASRGNYLIMPSGN-LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRR--STAE 227
++GN I SG LQI ED G Y C A N + + +L V S +
Sbjct: 1868 NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGE----TQQHIQLHVHEPPSLED 1923
Query: 228 AARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLID 287
A +++ +T++V+ + LEC A+G P P +TW KD ++G FL +ID
Sbjct: 1924 AGKMLN----ETVLVSN--PVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIID 1977
Query: 288 TTSEE--DSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCE 345
S + D+G Y+C+A N G A + Y++QV P ++ + + + +L CE
Sbjct: 1978 IESAQISDAGIYKCVAINSAG---ATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECE 2034
Query: 346 VRGNPPPSVLWLRNAVPLIS-SQRLRL--SRRALRVLSMGPEDEGVYQCMAENEVGSAHA 402
RG P PS+ WL++ P+ S S L++ R L + S D G Y C+A N G
Sbjct: 2035 ARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQR 2094
Query: 403 VVQLRTSRP--------SITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTS 454
+ LR P +++ + Q EL + + P L + G P L +P S
Sbjct: 2095 DIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTL---TWLKDGHPLLKKPGLS 2151
Query: 455 V 455
+
Sbjct: 2152 I 2152
Score = 117 bits (292), Expect = 8e-26
Identities = 112/389 (28%), Positives = 163/389 (41%), Gaps = 51/389 (13%)
Query: 40 VQPASTVQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNN 98
+ P K T+ L C P +++W +G+ L SDD + + TL I
Sbjct: 2679 LSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLK-SDDHVNIAANGHTLQIKEAQI 2737
Query: 99 HTVGRYQCVARMPAG-------AVASVPATVT----LANLQDFKLDVQHVIEVDEGNTAV 147
GRY CVA AG VP + + N+ D + + +V N
Sbjct: 2738 SDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGE-AKDVIINNPIS 2796
Query: 148 IACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGN-LQIVNASQEDEGMYKCAAYNPV 206
+ C + P Y K S LI+P G LQI A ED G Y C A N
Sbjct: 2797 LYCETNAAPPPTLTWY--KDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEA 2854
Query: 207 TQEVKTSGSSDRLRVRRSTAEAARIIYPP----------EAQTIIVTKGQSLILECVASG 256
++ S R++ PP E T++V K S ++EC++SG
Sbjct: 2855 GED--------------SLQYDVRVLVPPIIKGANSDLPEEVTVLVNK--SALIECLSSG 2898
Query: 257 IPPPRVTWAKDGSSVTGYNKTRFLLSN--LLIDTTSEEDSGTYRCMADNGVGQPGAAVIL 314
P PR +W KDG + + +FL + L I T D G Y C+A+N G+A
Sbjct: 2899 SPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAEN---TAGSAKKY 2955
Query: 315 YNVQVFEPPEVTMELSQ-LVIPWGQSAKLTCEVRGNPPPSVLWLRNAVP--LISSQRLRL 371
+N+ V PP V S+ L + LTCEV G PPP + WL+N P L ++ +
Sbjct: 2956 FNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVP 3015
Query: 372 SRRALRVLSMGPEDEGVYQCMAENEVGSA 400
R L+++ D G Y C+A N+ G +
Sbjct: 3016 GGRTLQIIRAKVSDGGEYTCIAINQAGES 3044
Score = 115 bits (287), Expect = 3e-25
Identities = 100/376 (26%), Positives = 155/376 (41%), Gaps = 23/376 (6%)
Query: 36 PQVTVQPASTVQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVIT 94
P + +P + ++ C P ++ W NG L D +L + G + I
Sbjct: 3897 PSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRIL-SSGAIEIL 3955
Query: 95 ALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQ-HVIEVDEGNTAVIACHLP 153
A + GRY CVAR AG S VTL + + Q + V N ++ C
Sbjct: 3956 ATQLNHAGRYTCVARNAAG---SAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEAT 4012
Query: 154 ESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTS 213
+ P + + + + S N+ ++PSG LQI A +ED G Y C A NP T+
Sbjct: 4013 GT-PSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAG----TA 4067
Query: 214 GSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTG 273
+L V+ + P + ++ + + L C A G+PPP +TW KDG ++
Sbjct: 4068 LGKIKLNVQVPP------VISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVE 4121
Query: 274 YNKTRFLLS-NLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQL 332
+ R L S +L I D+G Y CMA N G + + V PP +
Sbjct: 4122 SIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTST---KLTVHVPPRIRSTEGHY 4178
Query: 333 VIPWGQSAKLTCEVRGNPPPSVLWLRNAVPL--ISSQRLRLSRRALRVLSMGPEDEGVYQ 390
+ A L C G P P++ W ++ V L + + L + ++ ED G Y
Sbjct: 4179 TVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYT 4238
Query: 391 CMAENEVGSAHAVVQL 406
C+A N G V L
Sbjct: 4239 CVANNAAGEDTHTVSL 4254
Score = 114 bits (284), Expect = 7e-25
Identities = 112/396 (28%), Positives = 169/396 (42%), Gaps = 33/396 (8%)
Query: 61 PPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVG---RYQCVARMPAGAVAS 117
PP + +TW NG+ L + V I G + +NN +G Y CVA AG
Sbjct: 3649 PPPV-ITWLRNGERLQATPR---VRILSGGRYLQ-INNADLGDTANYTCVASNIAGKTTR 3703
Query: 118 VPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNY 177
+T+ + K Q ++ + +T V+ C + E P ++ + L + Y
Sbjct: 3704 -EFILTVNVPPNIKGGPQSLVILLNKST-VLEC-IAEGVPTPRITWRKDGAVLAGNHARY 3760
Query: 178 LIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEA 237
I+ +G L I +A D G Y C A N + +DR R+ I P
Sbjct: 3761 SILENGFLHIQSAHVTDTGRYLCMATN--------AAGTDRRRIDLQVHVPPSIAPGPTN 3812
Query: 238 QTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVT---GYNKTRFLLS-NLLIDTTSEED 293
T+IV +L C A+GIP P + W K+G + N R L S +L+I + S +D
Sbjct: 3813 MTVIVNVQTTLA--CEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDD 3870
Query: 294 SGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPS 353
+ TY C NG G V L VQV PP + E + ++ A +TC G P PS
Sbjct: 3871 TATYECTVTNGAGDDKRTVDL-TVQV--PPSIADEPTDFLVTKHAPAVITCTASGVPFPS 3927
Query: 354 VLWLRNAVPLI---SSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSR 410
+ W +N + L+ R+ LS A+ +L+ G Y C+A N GSAH V L
Sbjct: 3928 IHWTKNGIRLLPRGDGYRI-LSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHE 3986
Query: 411 PSITPRLWQDAELATGTPPVSPSK-LGNPEQMLRGQ 445
P + + + P + P + G P + Q
Sbjct: 3987 PPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQ 4022
Score = 110 bits (275), Expect = 7e-24
Identities = 90/334 (26%), Positives = 137/334 (41%), Gaps = 26/334 (7%)
Query: 89 GTLVITALNNHTVGRYQCVARMPAGAVASVPATVT--LANLQDFKLDVQHVIEVDEGNTA 146
G+L I + G Y CVA AG + V L +Q Q ++ EG
Sbjct: 943 GSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHG----QQILSTIEGIPV 998
Query: 147 VIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPV 206
+ C +PK V +S K E + S + G+L +V+ E+ G Y C A N
Sbjct: 999 TLPCKA-SGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATN-- 1055
Query: 207 TQEVKTSGSSDR-----LRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPR 261
T+G + R + VR R + + I V G+ + L C +PPP
Sbjct: 1056 -----TAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI 1110
Query: 262 VTWAKDGSSVTGYNKTRFLL--SNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQV 319
+TWAK+ ++ ++ L ++ I T DSG Y C+A N G AV L NV V
Sbjct: 1111 ITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKL-NVHV 1169
Query: 320 FEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSR--RALR 377
PP++ L + GQ + C +G P P + W + ++ +S L
Sbjct: 1170 --PPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLS 1227
Query: 378 VLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRP 411
+ P D G+Y C+A N G+ + L P
Sbjct: 1228 IDQATPSDAGIYTCVATNIAGTDETEITLHVQEP 1261
Score = 110 bits (275), Expect = 7e-24
Identities = 96/365 (26%), Positives = 147/365 (40%), Gaps = 39/365 (10%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGA-----VA 116
P +TW +G+ L +D + L L I+ GRY C+A PAG +
Sbjct: 3556 PAPKMTWMKDGRPLPQTDQ-VQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLV 3614
Query: 117 SVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGN 176
V +A D I V + C ++ P + + E L+A+
Sbjct: 3615 RVHVPPNIAGT-----DEPRDITVLRNRQVTLECK-SDAVPPPVITWLRNGERLQATPRV 3668
Query: 177 YLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPE 236
++ LQI NA D Y C A N +G + R + + PP
Sbjct: 3669 RILSGGRYLQINNADLGDTANYTCVASN-------IAGKTTREFI-------LTVNVPPN 3714
Query: 237 A----QTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN--LLIDTTS 290
Q++++ +S +LEC+A G+P PR+TW KDG+ + G + +L N L I +
Sbjct: 3715 IKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAH 3774
Query: 291 EEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNP 350
D+G Y CMA N G + ++QV PP + + + + L CE G P
Sbjct: 3775 VTDTGRYLCMATNAAGTDRRRI---DLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIP 3831
Query: 351 PPSVLWLRNAVPLISSQRLR----LSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQL 406
PS+ W +N L Q LS +L ++S +D Y+C N G V L
Sbjct: 3832 KPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDL 3891
Query: 407 RTSRP 411
P
Sbjct: 3892 TVQVP 3896
Score = 110 bits (274), Expect = 1e-23
Identities = 99/364 (27%), Positives = 153/364 (42%), Gaps = 38/364 (10%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHT-VGRYQCVARMPAGAVAS--- 117
P + W N K + SD +++ G+ + A + H+ G Y C+A G
Sbjct: 3179 PPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYF 3238
Query: 118 ----VPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEAS 173
VP +V A + DV ++ G + C+ P +++ +K AS
Sbjct: 3239 LSIQVPPSVAGAEIPS---DVSVLL----GENVELVCNA-NGIPTPLIQW-LKDGKPIAS 3289
Query: 174 RGNYLIMPSGN---LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAAR 230
I S N L I A D G Y C A NP +G DR+
Sbjct: 3290 GETERIRVSANGSTLNIYGALTSDTGKYTCVATNP-------AGEEDRIFNLNVYVTPTI 3342
Query: 231 IIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTS 290
EA+ ++ S+ +EC A+G PPP++ W K+G + + R L + +I
Sbjct: 3343 RGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVR 3402
Query: 291 EE--DSGTYRCMADNGVGQPGAAVILYNVQVFEPPEV--TMELSQLVIPWGQSAKLTCEV 346
+ D Y C+A N G YN+QVF PP + +M ++ + G S + C
Sbjct: 3403 AQVSDVAVYTCVASNRAGVDNKH---YNLQVFAPPNMDNSMGTEEITVLKGSSTSMACIT 3459
Query: 347 RGNPPPSVLWLRNAVPLISSQRLRLSRR--ALRVLSMGPEDEGVYQCMAENEVG--SAHA 402
G P PS+ WLR+ PL L +S L++L ED G Y C+A NE G S H
Sbjct: 3460 DGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHF 3519
Query: 403 VVQL 406
++++
Sbjct: 3520 ILKV 3523
Score = 108 bits (270), Expect = 3e-23
Identities = 105/397 (26%), Positives = 159/397 (40%), Gaps = 48/397 (12%)
Query: 41 QPASTVQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNH 99
Q ST++ G V L C P+ +V W G EL + A G+L + +
Sbjct: 988 QILSTIE--GIPVTLPCKASGNPKPSVIWSKKG-ELISTSSAKFSAGADGSLYVVSPGGE 1044
Query: 100 TVGRYQCVARMPAG-AVASVPATV-----TLANLQDFKLDVQHVIEVDEGNTAVIACHLP 153
G Y C A AG A V TV + + D I V G + C +
Sbjct: 1045 ESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEV- 1103
Query: 154 ESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYN---PVTQEV 210
+S P + ++ + + + + +PSG+++I D GMY C A N VTQ V
Sbjct: 1104 KSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAV 1163
Query: 211 KTSGSSDRLRVRRSTAEAARIIYPPEAQT----IIVTKGQSLILECVASGIPPPRVTWAK 266
K + + PP+ Q + V GQ + + C A G P P +TW+K
Sbjct: 1164 KLN-----------------VHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSK 1206
Query: 267 DGSS--VTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILY-----NVQV 319
GS+ V G + L ID + D+G Y C+A N G + L+ V+
Sbjct: 1207 GGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVED 1266
Query: 320 FEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQ---RLRLSRRAL 376
EPP T ++ Q + C +G P P++ WL N L + + L
Sbjct: 1267 LEPPYNTTFQERVA---NQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLL 1323
Query: 377 RVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSI 413
+ S+ P D G Y C+A NE G+ L+ P +
Sbjct: 1324 VIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPV 1360
Score = 107 bits (266), Expect = 8e-23
Identities = 101/396 (25%), Positives = 163/396 (41%), Gaps = 36/396 (9%)
Query: 20 CLLLATAGCFADLNEVPQVTVQPASTVQKPGGT---------VILGCVVEP-PRMNVTWR 69
C+ TAG D + +VTV T++ G + V L C+ P ++TW
Sbjct: 1805 CMAANTAG---DHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWL 1861
Query: 70 LNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVAS-VPATV-TLANL 127
+ + +N + L + + L I GRY CVA AG + V +L
Sbjct: 1862 KDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSL 1921
Query: 128 QDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQI 187
+D + + V N + C +P + + L S + + I
Sbjct: 1922 EDAGKMLNETVLVS--NPVQLECKAA-GNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDI 1978
Query: 188 VNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQS 247
+A D G+YKC A N S + L A I ++V
Sbjct: 1979 ESAQISDAGIYKCVAIN--------SAGATELFYSLQVHVAPSISGSNNMVAVVVNN--P 2028
Query: 248 LILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN---LLIDTTSEEDSGTYRCMADNG 304
+ LEC A GIP P +TW KDGS V+ ++ +LS L + + D+G Y C+A N
Sbjct: 2029 VRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNA 2088
Query: 305 VGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLI 364
G+ + +++V+ PP + E + + Q+ +L C+ PPP++ WL++ PL+
Sbjct: 2089 AGEKQRDI---DLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLL 2145
Query: 365 SSQRLRLS--RRALRVLSMGPEDEGVYQCMAENEVG 398
L +S R L++ +D G Y C A N G
Sbjct: 2146 KKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAG 2181
Score = 106 bits (265), Expect = 1e-22
Identities = 101/365 (27%), Positives = 138/365 (37%), Gaps = 33/365 (9%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVAS---- 117
P +TW +G L L + L I GRY C A AG
Sbjct: 2131 PPPTLTWLKDGHPLL-KKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNV 2189
Query: 118 ---VPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASR 174
VP + + D + V EGN + C P + L S
Sbjct: 2190 NIWVPPNIGGS-------DELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSM 2242
Query: 175 GNYLIMPSGN-LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIY 233
G I+ G LQI A + D +Y C A N K +R + + + +
Sbjct: 2243 GRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGS----H 2298
Query: 234 PPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN--LLIDTTSE 291
P E IIVT+G+S+ LEC GIPPP VTW KDG + L L +
Sbjct: 2299 PTE---IIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHV 2355
Query: 292 EDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVT---MELSQLVIPWGQSAKLTCEVRG 348
D+G Y C+A N G Y++ V PP + + + S LTCE G
Sbjct: 2356 SDTGRYVCVAVNVAGMTDKK---YDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASG 2412
Query: 349 NPPPSVLWLRNAVP--LISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQL 406
P PS+ W ++ P L +S R+ R LR++ ED G Y C+ N G + L
Sbjct: 2413 IPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGL 2472
Query: 407 RTSRP 411
P
Sbjct: 2473 SVLVP 2477
Score = 103 bits (258), Expect = 7e-22
Identities = 94/349 (26%), Positives = 142/349 (40%), Gaps = 27/349 (7%)
Query: 62 PRMNVTWRLNGKE-LNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVAS--- 117
P N+ W+ G L S + +L L I+ Y CVA AG
Sbjct: 2224 PPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYN 2283
Query: 118 --VPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRG 175
V T+ N + I V G + + C + + P V + L ++G
Sbjct: 2284 LQVYIRPTITNSGSHPTE----IIVTRGKSISLECEV-QGIPPPTVTWMKDGHPLIKAKG 2338
Query: 176 NYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPP 235
++ LQ+ N D G Y C A N +G +D+ A + I
Sbjct: 2339 VEILDEGHILQLKNIHVSDTGRYVCVAVN-------VAGMTDKKYDLSVHAPPSIIGNHR 2391
Query: 236 EAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN--LLIDTTSEED 293
+ I V + S+ L C ASGIP P +TW KDG V+ N R L L + T+ ED
Sbjct: 2392 SPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMED 2451
Query: 294 SGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTME--LSQLVIPWGQSAKLTCEVRGNPP 351
+G Y C+ N G+ ++ + V PP + E L + + QS LTCEV GNP
Sbjct: 2452 AGQYTCVVRNAAGEERK---IFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPV 2508
Query: 352 PSVLWLRNAVPLISSQRLRL--SRRALRVLSMGPEDEGVYQCMAENEVG 398
P + W ++ PL + + R L++ ++ G Y C+A + G
Sbjct: 2509 PEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAG 2557
Score = 103 bits (256), Expect = 1e-21
Identities = 99/372 (26%), Positives = 153/372 (41%), Gaps = 33/372 (8%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVAS---- 117
P +TW +G L S+ + +L TL I GRY CVA AG +
Sbjct: 2603 PPATITWFKDGTPLE-SNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEV 2661
Query: 118 ---VPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASR 174
+P + +L L + V ++ NT + C + P A + + + L++
Sbjct: 2662 KVYIPPIINKGDLWGPGLSPKEV-KIKVNNTLTLECEA-YAIPSASLSWYKDGQPLKSDD 2719
Query: 175 GNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQE-------VKTSGSSDRLRVRRSTAE 227
+ LQI A D G Y C A N ++ ++ S +L + +
Sbjct: 2720 HVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLD 2779
Query: 228 AARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN--LL 285
R EA+ +I+ SL C + PPP +TW KDG +T +K L L
Sbjct: 2780 TGR---NGEAKDVIINNPISLY--CETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQ 2834
Query: 286 IDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQL----VIPWGQSAK 341
I ED+G Y C+A N G+ + Y+V+V PP + S L + +SA
Sbjct: 2835 IPRAKVEDAGRYTCVAVNEAGEDS---LQYDVRVLVPPIIKGANSDLPEEVTVLVNKSAL 2891
Query: 342 LTCEVRGNPPPSVLWLRNAVPLISSQRLRL--SRRALRVLSMGPEDEGVYQCMAENEVGS 399
+ C G+P P W ++ PL+ + + R L++L+ D G Y C+AEN GS
Sbjct: 2892 IECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGS 2951
Query: 400 AHAVVQLRTSRP 411
A L P
Sbjct: 2952 AKKYFNLNVHVP 2963
Score = 99.8 bits (247), Expect = 1e-20
Identities = 98/387 (25%), Positives = 165/387 (42%), Gaps = 37/387 (9%)
Query: 52 TVILGC-VVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARM 110
+V L C V P +TW +G+ L D+A ++ L IT + GRY C+A
Sbjct: 2496 SVTLTCEVTGNPVPEITWHKDGQPLQ-EDEAHHIISGGRFLQITNVQVPHTGRYTCLASS 2554
Query: 111 PAGAVA-----SVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSV 165
PAG + +V + T+A + + ++ + V + S+P A + +
Sbjct: 2555 PAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAY---SYPPATITWFK 2611
Query: 166 KQEWLEASRGNYLIMPSGN-LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRS 224
LE++R N I+P G LQI+NA +++ G Y C A N + +K ++V
Sbjct: 2612 DGTPLESNR-NIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIK----HYEVKVYIP 2666
Query: 225 TAEAARIIYPP--EAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLS 282
++ P + + + +L LEC A IP ++W KDG + + +
Sbjct: 2667 PIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAAN 2726
Query: 283 --NLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPP--EVTMELSQLV----- 333
L I D+G Y C+A N G+ + ++V + PP + E+ ++
Sbjct: 2727 GHTLQIKEAQISDTGRYTCVASNIAGED---ELDFDVNIQVPPSFQKLWEIGNMLDTGRN 2783
Query: 334 -----IPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL--SRRALRVLSMGPEDE 386
+ L CE PPP++ W ++ PL SS ++ + R L++ ED
Sbjct: 2784 GEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDA 2843
Query: 387 GVYQCMAENEVGSAHAVVQLRTSRPSI 413
G Y C+A NE G +R P I
Sbjct: 2844 GRYTCVAVNEAGEDSLQYDVRVLVPPI 2870
Score = 99.8 bits (247), Expect = 1e-20
Identities = 93/361 (25%), Positives = 152/361 (42%), Gaps = 49/361 (13%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVAS---- 117
P +W+ +G+ L DD L L I +GRY CVA AG+
Sbjct: 2900 PAPRNSWQKDGQPLL-EDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNL 2958
Query: 118 ---VPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASR 174
VP +V ++ + V + I + C + P + + ++ ++ +
Sbjct: 2959 NVHVPPSVIGPKSENLTVVVNNFIS--------LTCEV-SGFPPPDLSWLKNEQPIKLNT 3009
Query: 175 GNYLIMPSGN-LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRL--RVRRSTAEAARI 231
N LI+P G LQI+ A D G Y C A N + K + + ++ +E+ +
Sbjct: 3010 -NTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSV 3068
Query: 232 IYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSE 291
+ V +G S+ LEC ++ +PPP +TW K+G +T L ++
Sbjct: 3069 VN--------VREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKA 3120
Query: 292 E--DSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVT-MELSQLVIPWGQSAKLTCEVRG 348
E D+G Y C A N G+ +++ V+ PP + E +V LTC+ G
Sbjct: 3121 EVSDTGQYVCRAINVAGRDDKN---FHLNVYVPPSIEGPEREVIVETISNPVTLTCDATG 3177
Query: 349 NPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPE---------DEGVYQCMAENEVGS 399
PPP++ WL+N + +S L +R+LS G + D G Y C+A N G
Sbjct: 3178 IPPPTIAWLKNHKRIENSDSLE-----VRILSGGSKLQIARSQHSDSGNYTCIASNMEGK 3232
Query: 400 A 400
A
Sbjct: 3233 A 3233
Score = 96.3 bits (238), Expect = 1e-19
Identities = 118/473 (24%), Positives = 188/473 (39%), Gaps = 48/473 (10%)
Query: 24 ATAGCFADLNEVPQVTVQPASTVQKPGGTVILGCVVEP-PRMNVTWR-LNGKELNGSDDA 81
AT D+ P +PA + G V L C V+ P + WR L+ + +
Sbjct: 781 ATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFS 840
Query: 82 LGVL--ITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQ-HVI 138
+ + + G L I L G Y C A G + S TVT+ L + + V
Sbjct: 841 VSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQS-ETTVTVTGLVAPLIGISPSVA 899
Query: 139 EVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMY 198
V EG + C L +P + R+ +K + + G+L I +D G Y
Sbjct: 900 NVIEGQQLTLPCTLLAGNPIPERRW-IKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEY 958
Query: 199 KCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIP 258
C A N KT +S + V + +I+ TI +G + L C ASG P
Sbjct: 959 TCVASNVAGTNNKT--TSVVVHVLPTIQHGQQIL-----STI---EGIPVTLPCKASGNP 1008
Query: 259 PPRVTWAKDGSSVTGYNKTRFLL---SNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILY 315
P V W+K G ++ + +F +L + + E+SG Y C A N G V
Sbjct: 1009 KPSVIWSKKGELIS-TSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKV--- 1064
Query: 316 NVQVFEPPEVTME---LSQ-----LVIPWGQSAKLTCEVRGNPPPSVLWLRNA--VPLIS 365
+ V+ P V + LSQ + + G+ L CEV+ PPP + W + + S
Sbjct: 1065 QLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFS 1124
Query: 366 SQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRP--------SITPRL 417
+ L ++++ D G+Y C+A N G+ V+L P + ++
Sbjct: 1125 PRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQV 1184
Query: 418 WQDAEL---ATGTP-PVSPSKLGNPEQMLRGQPALPRP--PTSVGPASPQCPG 464
Q ++ A GTP PV G ++ G+ + P S+ A+P G
Sbjct: 1185 GQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAG 1237
Score = 95.9 bits (237), Expect = 2e-19
Identities = 98/362 (27%), Positives = 148/362 (40%), Gaps = 36/362 (9%)
Query: 53 VILGCVVE-PPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMP 111
V L C V+ P ++ W +GK L D + +L L + + GRYQC
Sbjct: 1471 VALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNA 1530
Query: 112 AGAVAS-------VPATVTLANLQ-DFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRY 163
AG A +P ++ N+ D + + +I+++ C A Y
Sbjct: 1531 AGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLE--------CETRGLPMPAITWY 1582
Query: 164 SVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRR 223
Q + +S+ Y I L I A D Y C N T+ S + V
Sbjct: 1583 KDGQPIMSSSQALY-IDKGQYLHIPRAQVSDSATYTCHVANVAG----TAEKSFHVDVYV 1637
Query: 224 STAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLL-- 281
+ P Q +I SL LEC A+G P P +TW KDG V + R
Sbjct: 1638 PPMIEGNLATPLNKQVVIA---HSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGG 1694
Query: 282 SNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVT--MELSQLVIPWGQS 339
L I + E D G Y C+A + G+ I Y V V PP + E S ++
Sbjct: 1695 KKLEIMSAQEIDRGQYICVATSVAGE---KEIKYEVDVLVPPAIEGGDETSYFIVMVNNL 1751
Query: 340 AKLTCEVRGNPPPSVLWLRNAVPLISSQ---RLRLSRRALRVLSMGPEDEGVYQCMAENE 396
+L C V G+PPP+++WL++ LI + ++ L+ R L + + G+Y+CMA N
Sbjct: 1752 LELDCHVTGSPPPTIMWLKDG-QLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANT 1810
Query: 397 VG 398
G
Sbjct: 1811 AG 1812
Score = 95.9 bits (237), Expect = 2e-19
Identities = 101/388 (26%), Positives = 158/388 (40%), Gaps = 50/388 (12%)
Query: 48 KPGGTVILGC---VVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRY 104
+ G +V L C V PP +TW NG+ + S + +L L I G+Y
Sbjct: 3072 REGTSVSLECESNAVPPPV--ITWYKNGRMITESTH-VEILADGQMLHIKKAEVSDTGQY 3128
Query: 105 QCVARMPAGAVASVPATVTLANLQDFKLDV----------QHVIEVDEGNTAVIACHLPE 154
C A AG + ++F L+V + VI N + C
Sbjct: 3129 VCRAINVAGR-----------DDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDAT- 3176
Query: 155 SHPKAQVRYSVKQEWLEASRGNYLIMPSGN--LQIVNASQEDEGMYKCAAYNPVTQEVKT 212
P + + + +E S + + SG LQI + D G Y C A N + K
Sbjct: 3177 GIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKY 3236
Query: 213 SGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVT 272
S ++V S A A P + ++ G+++ L C A+GIP P + W KDG +
Sbjct: 3237 YFLS--IQVPPSVAGAE---IPSDVSVLL---GENVELVCNANGIPTPLIQWLKDGKPIA 3288
Query: 273 GYNKTRFLLS----NLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTM- 327
R +S L I D+G Y C+A N G+ ++N+ V+ P +
Sbjct: 3289 SGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDR---IFNLNVYVTPTIRGN 3345
Query: 328 --ELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL--SRRALRVLSMGP 383
E +L+ S + C G PPP + WL+N +PL S +RL + + +R++
Sbjct: 3346 KDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQV 3405
Query: 384 EDEGVYQCMAENEVGSAHAVVQLRTSRP 411
D VY C+A N G + L+ P
Sbjct: 3406 SDVAVYTCVASNRAGVDNKHYNLQVFAP 3433
Score = 95.5 bits (236), Expect = 2e-19
Identities = 93/360 (25%), Positives = 143/360 (39%), Gaps = 47/360 (13%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPAT 121
P+ + W NG+EL G + + +L LVI ++ + G Y CVA AG
Sbjct: 1294 PKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAG-------- 1345
Query: 122 VTLANLQDFKLDVQHVIEVDE--GNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLI 179
T + K+ V VI+ E N +V+ L + + S W + N +
Sbjct: 1346 -TTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWY---KDNVQV 1401
Query: 180 MPSGNLQIVN---------ASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAAR 230
S +Q VN A+ ED G Y C A N +G+S +
Sbjct: 1402 TESSTIQTVNNGKILKLFRATPEDAGRYSCKAIN-------IAGTSQKY-FNIDVLVPPT 1453
Query: 231 IIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN---LLID 287
II + V + + LEC G P P + W KDG + + LL L +
Sbjct: 1454 IIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLK 1513
Query: 288 TTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPP-----EVTMELSQLVIPWGQSAKL 342
D G Y+C N G+ + + ++ PP VT ++S L+ KL
Sbjct: 1514 NARRNDKGRYQCTVSNAAGKQAKDI---KLTIYIPPSIKGGNVTTDISVLI---NSLIKL 1567
Query: 343 TCEVRGNPPPSVLWLRNAVPLI-SSQRLRLSR-RALRVLSMGPEDEGVYQCMAENEVGSA 400
CE RG P P++ W ++ P++ SSQ L + + + L + D Y C N G+A
Sbjct: 1568 ECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTA 1627
Score = 94.4 bits (233), Expect = 6e-19
Identities = 87/371 (23%), Positives = 148/371 (39%), Gaps = 24/371 (6%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPAT 121
P ++TW +G ++ S+ ++ +L L + G+Y CV R AG +
Sbjct: 2414 PLPSITWFKDGWPVSLSN-SVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGL 2472
Query: 122 VTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMP 181
L + ++V E + + C + +P ++ + + L+ +++I
Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVT-GNPVPEITWHKDGQPLQEDEAHHIISG 2531
Query: 182 SGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRS-TAEAARIIYPPEAQTI 240
LQI N G Y C A +P + + S L V S T PE T+
Sbjct: 2532 GRFLQITNVQVPHTGRYTCLASSPAGHKSR----SFSLNVFVSPTIAGVGSDGNPEDVTV 2587
Query: 241 IVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN--LLIDTTSEEDSGTYR 298
I+ SL+ C A PP +TW KDG+ + R L L I E+++G Y
Sbjct: 2588 ILNSPTSLV--CEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYS 2645
Query: 299 CMADNGVGQPGAAVILYNVQVFEPPEVT--------MELSQLVIPWGQSAKLTCEVRGNP 350
C+A N G+ + Y V+V+ PP + + ++ I + L CE P
Sbjct: 2646 CVATNEAGE---MIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIP 2702
Query: 351 PPSVLWLRNAVPLISSQRLRLSRRA--LRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRT 408
S+ W ++ PL S + ++ L++ D G Y C+A N G +
Sbjct: 2703 SASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNI 2762
Query: 409 SRPSITPRLWQ 419
P +LW+
Sbjct: 2763 QVPPSFQKLWE 2773
Score = 92.4 bits (228), Expect = 2e-18
Identities = 68/220 (30%), Positives = 97/220 (44%), Gaps = 17/220 (7%)
Query: 185 LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTK 244
LQ++ A ED G Y C A N + K E I E + I V
Sbjct: 3491 LQLLKAETEDSGKYTCIASNEAGEVSK--------HFILKVLEPPHINGSEEHEEISVIV 3542
Query: 245 GQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN--LLIDTTSEEDSGTYRCMAD 302
L L C+ASGIP P++TW KDG + ++ + L L I T ED+G Y C+A
Sbjct: 3543 NNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLAS 3602
Query: 303 NGVGQPGAAVILYNVQVFEPPEV--TMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNA 360
+ G Y V+V PP + T E + + + L C+ PPP + WLRN
Sbjct: 3603 SPAGDDDKE---YLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNG 3659
Query: 361 VPLISSQRLRL--SRRALRVLSMGPEDEGVYQCMAENEVG 398
L ++ R+R+ R L++ + D Y C+A N G
Sbjct: 3660 ERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAG 3699
Score = 92.0 bits (227), Expect = 3e-18
Identities = 90/366 (24%), Positives = 145/366 (39%), Gaps = 38/366 (10%)
Query: 102 GRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQV 161
G Y+C+A AG + T + + V + + V G AV+ C + + V
Sbjct: 495 GFYECIAVSSAGTGRA--QTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISA-----V 547
Query: 162 RYSVKQEWLEASRGNYLIMPSGNLQIVNASQE-------DEGMYKCAAYNPVTQEVKTSG 214
Y++ W R L P+ + N S E D G Y C V + G
Sbjct: 548 DYNLT--WQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCM--------VSSEG 597
Query: 215 SSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGY 274
S V + E ++ P+ Q+ T G + + C A+G P P++ W + + G
Sbjct: 598 GSSAASVFLTVQEPPKVTVMPKNQSF--TGGSEVSIMCSATGYPKPKIAWTVNDMFIVGS 655
Query: 275 NKTRFLLSN-LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLV 333
++ R L I + +D+G Y C+A N G L + E P++ + S+L+
Sbjct: 656 HRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTL---RYIEAPKLMVVQSELL 712
Query: 334 IPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRA--LRVLSMGPEDEGVYQC 391
+ G + C+ G PPP V W + + L S L + L++ D G Y C
Sbjct: 713 VALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTC 772
Query: 392 MAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKL-GNPE-----QMLRGQ 445
+A NE G A + L P + + D + G+ P + G PE + L
Sbjct: 773 VAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNM 832
Query: 446 PALPRP 451
P RP
Sbjct: 833 PIFSRP 838
Score = 91.3 bits (225), Expect = 5e-18
Identities = 63/222 (28%), Positives = 98/222 (44%), Gaps = 17/222 (7%)
Query: 182 SGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTII 241
S NL I + DEG Y+C A + S + R + +E +I P +
Sbjct: 481 SVNLDIAKVTLSDEGFYECIAVS--------SAGTGRAQTFFDVSEPPPVIQVPN--NVT 530
Query: 242 VTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRF-LLSNLLIDTTSEE--DSGTYR 298
VT G+ +L C+ +TW ++ V R L+NL ++ S + D+G Y
Sbjct: 531 VTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYH 590
Query: 299 CMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLR 358
CM + G A+V L V EPP+VT+ G + C G P P + W
Sbjct: 591 CMVSSEGGSSAASVFL---TVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTV 647
Query: 359 NAVPLISSQRLRL-SRRALRVLSMGPEDEGVYQCMAENEVGS 399
N + ++ S R R+ S L + + P+D G+Y C+A N G+
Sbjct: 648 NDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGT 689
Score = 82.8 bits (203), Expect = 2e-15
Identities = 82/314 (26%), Positives = 133/314 (42%), Gaps = 19/314 (6%)
Query: 88 HGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAV 147
+G L++ + G Y CVA AG ++T+ L F ++ + +++G
Sbjct: 4221 YGELILENVVLEDSGFYTCVANNAAGEDTHT-VSLTVHVLPTFT-ELPGDVSLNKGEQLR 4278
Query: 148 IACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVT 207
++C P ++ ++ + A + + L I S+ED G Y C A N V
Sbjct: 4279 LSCKAT-GIPLPKLTWTFNNNIIPAHFDS--VNGHSELVIERVSKEDSGTYVCTAENSVG 4335
Query: 208 QEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKD 267
VK G V + YP I G + IL C G P P + W +
Sbjct: 4336 F-VKAIGF-----VYVKEPPVFKGDYP---SNWIEPLGGNAILNCEVKGDPTPTIQWNRK 4386
Query: 268 GSSVTGYNKTRFLLS-NLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVT 326
G + ++ R L + +L I T ED+G Y C+A N G ++ L + PP +T
Sbjct: 4387 GVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSL---TLQSPPIIT 4443
Query: 327 MELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLR-LSRRALRVLSMGPED 385
+E + VI G L C+ G P P++ W R + R+ LS +L + ED
Sbjct: 4444 LEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKED 4503
Query: 386 EGVYQCMAENEVGS 399
++C+A N +GS
Sbjct: 4504 TSEFECVARNLMGS 4517
Score = 75.1 bits (183), Expect = 3e-13
Identities = 71/274 (25%), Positives = 115/274 (41%), Gaps = 18/274 (6%)
Query: 35 VPQVTVQPASTVQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVI 93
+P T P G + L C P +TW N + D++ H LVI
Sbjct: 4259 LPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVN---GHSELVI 4315
Query: 94 TALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLP 153
++ G Y C A G V ++ V + FK D G A++ C +
Sbjct: 4316 ERVSKEDSGTYVCTAENSVGFVKAI-GFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEV- 4373
Query: 154 ESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTS 213
+ P ++++ K +E S + +G+L I ED G Y C A N +
Sbjct: 4374 KGDPTPTIQWNRKGVDIEISH-RIRQLGNGSLAIYGTVNEDAGDYTCVATNE-------A 4425
Query: 214 GSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTG 273
G +R T ++ II +T+I G +IL C A+G P P +TW++ G S++
Sbjct: 4426 GVVERSM--SLTLQSPPIITLEPVETVI-NAGGKIILNCQATGEPQPTITWSRQGHSISW 4482
Query: 274 YNKTRFLLSN-LLIDTTSEEDSGTYRCMADNGVG 306
++ L +N L I +ED+ + C+A N +G
Sbjct: 4483 DDRVNVLSNNSLYIADAQKEDTSEFECVARNLMG 4516
Score = 74.7 bits (182), Expect = 5e-13
Identities = 90/386 (23%), Positives = 147/386 (38%), Gaps = 31/386 (8%)
Query: 36 PQVTVQPASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDDALGVLITHGTLVIT 94
P++ P + G V + C + P +TW G + D V GTL I
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTML-VDGEHHVSNPDGTLSID 1229
Query: 95 ALNNHTVGRYQCVARMPAGAVASVPATVTL-----ANLQDFKLDVQHVIEVDEGNTAVIA 149
G Y CVA AG + +TL ++D + + N +
Sbjct: 1230 QATPSDAGIYTCVATNIAGTDET---EITLHVQEPPTVEDLEPPYNTTFQERVANQRIEF 1286
Query: 150 CHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIV-NASQEDEGMYKCAAYNPVTQ 208
+ PK +++ L I+ G L ++ + + D G Y C A N
Sbjct: 1287 PCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVN---- 1342
Query: 209 EVKTSGSSDRLRVRRSTAEAARIIYPPEAQT-IIVTKGQSLILECVASGIPPPRVTWAKD 267
E T+ L+V +I E T + V Q L C G P P + W KD
Sbjct: 1343 EAGTTERKYNLKVH-----VPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKD 1397
Query: 268 GSSVTGYNKTRFLLSNLLIDT--TSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEV 325
VT + + + + ++ + ED+G Y C A N G + +N+ V PP +
Sbjct: 1398 NVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAG---TSQKYFNIDVLVPPTI 1454
Query: 326 --TMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPL-ISSQRLRLSRRA--LRVLS 380
T +++ + + L C+V+G P P + W ++ PL + + L R L + +
Sbjct: 1455 IGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKN 1514
Query: 381 MGPEDEGVYQCMAENEVGSAHAVVQL 406
D+G YQC N G ++L
Sbjct: 1515 ARRNDKGRYQCTVSNAAGKQAKDIKL 1540
Score = 57.0 bits (136), Expect = 1e-07
Identities = 53/190 (27%), Positives = 86/190 (45%), Gaps = 12/190 (6%)
Query: 227 EAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSS--VTGYNKTRFLLSNL 284
+A ++ P + + GQ + C + P +++ ++G + V Y K + NL
Sbjct: 429 DAPKVTMPEKTPGYYLQPGQ---IPCSVDSLLPFTLSFVRNGVTLGVDQYLKESASV-NL 484
Query: 285 LIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTC 344
I + D G Y C+A + G G A ++V EPP V + + + G+ A LTC
Sbjct: 485 DIAKVTLSDEGFYECIAVSSAGT-GRAQTFFDVS--EPPPVIQVPNNVTVTPGERAVLTC 541
Query: 345 EVRGNPPPSVLWLRNA--VPLISSQRLR-LSRRALRVLSMGPEDEGVYQCMAENEVGSAH 401
+ ++ W RN V L R+R L+ +L + S+ D G Y CM +E GS+
Sbjct: 542 LIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSA 601
Query: 402 AVVQLRTSRP 411
A V L P
Sbjct: 602 ASVFLTVQEP 611
Score = 46.2 bits (108), Expect = 2e-04
Identities = 30/93 (32%), Positives = 45/93 (48%), Gaps = 4/93 (4%)
Query: 32 LNEVPQVTVQPASTVQKPGGTVILGC-VVEPPRMNVTWRLNGKELNGSDDALGVLITHGT 90
L P +T++P TV GG +IL C P+ +TW G ++ DD + VL ++ +
Sbjct: 4436 LQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISW-DDRVNVL-SNNS 4493
Query: 91 LVITALNNHTVGRYQCVARMPAGAV-ASVPATV 122
L I ++CVAR G+V VP V
Sbjct: 4494 LYIADAQKEDTSEFECVARNLMGSVLVRVPVIV 4526
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 133 bits (334), Expect = 1e-30
Identities = 184/789 (23%), Positives = 293/789 (37%), Gaps = 114/789 (14%)
Query: 36 PQVTVQPASTVQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGSDD---ALGVLITHGTL 91
P++ P+ + G L C E P + W +G+ + D + +L+ G+L
Sbjct: 47 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 106
Query: 92 VITAL-----NNHTVGRYQCVARMPAGAVASVPATVTLANLQD-FKLDVQHVIEVDEGNT 145
+ + G Y CVAR G S A++ +A L+D F+ + V+ V G
Sbjct: 107 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVV-VAAGEP 165
Query: 146 AVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNP 205
A++ C P HP+ + Y K + + + + G L I N + D GMY C N
Sbjct: 166 AILECQPPRGHPEPTI-YWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNM 224
Query: 206 VTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWA 265
V G D + E + P Q +V + +++ C G P P V W
Sbjct: 225 V-------GERDSDPAELTVFERPTFLRRPINQ--VVLEEEAVEFRCQVQGDPQPTVRWK 275
Query: 266 KDGSSVTGYNKTRFLLSN---LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEP 322
KD + + + R+ + + L I T D GTY C+A+N VG+ A+ L V P
Sbjct: 276 KDDADLP---RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATL---TVRAP 329
Query: 323 PEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVP--LISSQRLRLSRRA----- 375
P+ + ++ G++ CE +GNP P+V W + L +Q + + R
Sbjct: 330 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 389
Query: 376 --LRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPS 433
L + ++ D G Y C A GS A QL + L PP+
Sbjct: 390 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVT-----------DVLTDRPPPIILQ 438
Query: 434 KLGNPEQMLRGQPAL-------PRPPTSVGPASPQCPGEKGQGAPAE-APIILSSPRTSK 485
N + G L P P S PG + E + + + R S
Sbjct: 439 GPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISD 498
Query: 486 TDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLD----- 540
T +Y V + + +L ++ + D + G P+ +T+
Sbjct: 499 TGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSW 558
Query: 541 --------PGSLYEVEMAAYNCAGEGQTAMVTFRT------GRRPKP----EIMASKEQQ 582
P S Y +E + + + QT +T G RP + A Q
Sbjct: 559 QPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQG 618
Query: 583 IQRDDPGASP---QSSSQPDHG---RLSPPEAPD------RPTISTASETSVYVTWIPRG 630
+ P + P Q S P G R E D P + T T+V VTW
Sbjct: 619 LSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLT--PTTVQVTWTVDR 676
Query: 631 NGGFPIQSFRVEYKK---LKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRAL--N 685
F IQ +RV Y++ L+ W + +P R +V + L+KG +Y+ +VR
Sbjct: 677 QPQF-IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAV-LVNLKKGVTYEIKVRPYFNE 734
Query: 686 MLGESEPSAPSRPYVVSGYSGRVYERPVAGPY---ITFTDAVNETTIMLKWMYIPASNNN 742
G S R E P A P + + N T+I + W P + N
Sbjct: 735 FQGMDSESKTVR---------TTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQN 785
Query: 743 TPIHGFYIY 751
I + I+
Sbjct: 786 GIIQEYKIW 794
Score = 67.8 bits (164), Expect = 6e-11
Identities = 51/199 (25%), Positives = 90/199 (45%), Gaps = 17/199 (8%)
Query: 213 SGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSV- 271
+G R+R+ + +P + +IV+KG+ L C A G P P + W KDG V
Sbjct: 32 NGQGQGSRLRQEDFPPRIVEHPSD---VIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVE 88
Query: 272 ---TGYNKTRFLLSN-------LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFE 321
R LL + ++ S+ D G+Y C+A N +G+ + V +
Sbjct: 89 TDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLR 148
Query: 322 PPEVTMELSQLVIPWGQSAKLTCE-VRGNPPPSVLWLRNAVPL-ISSQRLRLSRRALRVL 379
+ + +V+ G+ A L C+ RG+P P++ W ++ V + +R+ + L +
Sbjct: 149 -DDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMIS 207
Query: 380 SMGPEDEGVYQCMAENEVG 398
+ D G+Y C+ N VG
Sbjct: 208 NTRKSDAGMYTCVGTNMVG 226
Score = 56.6 bits (135), Expect = 1e-07
Identities = 71/292 (24%), Positives = 118/292 (40%), Gaps = 22/292 (7%)
Query: 34 EVPQVTVQPASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKEL-NGSDDALGVLITHGTL 91
E P +P + V V C V+ P+ V W+ + +L G D + TL
Sbjct: 239 ERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYD----IKDDYTL 294
Query: 92 VITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACH 151
I + G Y C+A G + + AT+T+ F + + I V +G T C
Sbjct: 295 RIKKTMSTDEGTYMCIAENRVGKMEA-SATLTVRAPPQFVVRPRDQI-VAQGRTVTFPCE 352
Query: 152 LPESHPKAQVRYSVK--QEWL-----EASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYN 204
+ +P+ V + + Q L + + P+G+L I N + D G Y C A
Sbjct: 353 T-KGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALT 411
Query: 205 PVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTW 264
V + + V I+ P QT+ V + +L+C A+G P P ++W
Sbjct: 412 -VAGSILAKAQLEVTDVLTDRPPPI-ILQGPANQTLAVDG--TALLKCKATGDPLPVISW 467
Query: 265 AKDGSSVTGYNKTRFL--LSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVIL 314
K+G + G + + L I D+GTY C+A + G+ + +L
Sbjct: 468 LKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVL 519
Score = 50.8 bits (120), Expect = 7e-06
Identities = 52/217 (23%), Positives = 86/217 (39%), Gaps = 19/217 (8%)
Query: 606 PEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLS 665
P P +P ++ ++ SV ++W P G P ++ +E W + + + +
Sbjct: 538 PGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYT 597
Query: 666 VEITGLEKGTSYKFRVRALNMLGESEPSAPSRPY-------VVSGYSGRVYERPVAGPYI 718
V GL T Y F VRA+N G S+PS S P G R ++ + +
Sbjct: 598 VR--GLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLV 655
Query: 719 TFTDAV--NETTIMLKWMYIPASNNNTPIHGFYIYYRPTD--SDNDSDYKKDMVEGDKYW 774
+ V TT+ + W I G+ + YR T S D +
Sbjct: 656 RLHNPVVLTPTTVQVTW---TVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERS 712
Query: 775 HSISHLQPETSYDIKMQ-CFNE--GGESEFSNVMICE 808
+ +L+ +Y+IK++ FNE G +SE V E
Sbjct: 713 AVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTE 749
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 133 bits (334), Expect = 1e-30
Identities = 184/789 (23%), Positives = 293/789 (37%), Gaps = 114/789 (14%)
Query: 36 PQVTVQPASTVQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGSDD---ALGVLITHGTL 91
P++ P+ + G L C E P + W +G+ + D + +L+ G+L
Sbjct: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
Query: 92 VITAL-----NNHTVGRYQCVARMPAGAVASVPATVTLANLQD-FKLDVQHVIEVDEGNT 145
+ + G Y CVAR G S A++ +A L+D F+ + V+ V G
Sbjct: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVV-VAAGEP 149
Query: 146 AVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNP 205
A++ C P HP+ + Y K + + + + G L I N + D GMY C N
Sbjct: 150 AILECQPPRGHPEPTI-YWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNM 208
Query: 206 VTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWA 265
V G D + E + P Q +V + +++ C G P P V W
Sbjct: 209 V-------GERDSDPAELTVFERPTFLRRPINQ--VVLEEEAVEFRCQVQGDPQPTVRWK 259
Query: 266 KDGSSVTGYNKTRFLLSN---LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEP 322
KD + + + R+ + + L I T D GTY C+A+N VG+ A+ L V P
Sbjct: 260 KDDADLP---RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATL---TVRAP 313
Query: 323 PEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVP--LISSQRLRLSRRA----- 375
P+ + ++ G++ CE +GNP P+V W + L +Q + + R
Sbjct: 314 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
Query: 376 --LRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPS 433
L + ++ D G Y C A GS A QL + L PP+
Sbjct: 374 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVT-----------DVLTDRPPPIILQ 422
Query: 434 KLGNPEQMLRGQPAL-------PRPPTSVGPASPQCPGEKGQGAPAE-APIILSSPRTSK 485
N + G L P P S PG + E + + + R S
Sbjct: 423 GPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISD 482
Query: 486 TDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLD----- 540
T +Y V + + +L ++ + D + G P+ +T+
Sbjct: 483 TGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSW 542
Query: 541 --------PGSLYEVEMAAYNCAGEGQTAMVTFRT------GRRPKP----EIMASKEQQ 582
P S Y +E + + + QT +T G RP + A Q
Sbjct: 543 QPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQG 602
Query: 583 IQRDDPGASP---QSSSQPDHG---RLSPPEAPD------RPTISTASETSVYVTWIPRG 630
+ P + P Q S P G R E D P + T T+V VTW
Sbjct: 603 LSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLT--PTTVQVTWTVDR 660
Query: 631 NGGFPIQSFRVEYKK---LKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRAL--N 685
F IQ +RV Y++ L+ W + +P R +V + L+KG +Y+ +VR
Sbjct: 661 QPQF-IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAV-LVNLKKGVTYEIKVRPYFNE 718
Query: 686 MLGESEPSAPSRPYVVSGYSGRVYERPVAGPY---ITFTDAVNETTIMLKWMYIPASNNN 742
G S R E P A P + + N T+I + W P + N
Sbjct: 719 FQGMDSESKTVR---------TTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQN 769
Query: 743 TPIHGFYIY 751
I + I+
Sbjct: 770 GIIQEYKIW 778
Score = 56.6 bits (135), Expect = 1e-07
Identities = 71/292 (24%), Positives = 118/292 (40%), Gaps = 22/292 (7%)
Query: 34 EVPQVTVQPASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKEL-NGSDDALGVLITHGTL 91
E P +P + V V C V+ P+ V W+ + +L G D + TL
Sbjct: 223 ERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYD----IKDDYTL 278
Query: 92 VITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACH 151
I + G Y C+A G + + AT+T+ F + + I V +G T C
Sbjct: 279 RIKKTMSTDEGTYMCIAENRVGKMEA-SATLTVRAPPQFVVRPRDQI-VAQGRTVTFPCE 336
Query: 152 LPESHPKAQVRYSVK--QEWL-----EASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYN 204
+ +P+ V + + Q L + + P+G+L I N + D G Y C A
Sbjct: 337 T-KGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALT 395
Query: 205 PVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTW 264
V + + V I+ P QT+ V + +L+C A+G P P ++W
Sbjct: 396 -VAGSILAKAQLEVTDVLTDRPPPI-ILQGPANQTLAVDG--TALLKCKATGDPLPVISW 451
Query: 265 AKDGSSVTGYNKTRFL--LSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVIL 314
K+G + G + + L I D+GTY C+A + G+ + +L
Sbjct: 452 LKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVL 503
Score = 50.8 bits (120), Expect = 7e-06
Identities = 52/217 (23%), Positives = 86/217 (39%), Gaps = 19/217 (8%)
Query: 606 PEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLS 665
P P +P ++ ++ SV ++W P G P ++ +E W + + + +
Sbjct: 522 PGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYT 581
Query: 666 VEITGLEKGTSYKFRVRALNMLGESEPSAPSRPY-------VVSGYSGRVYERPVAGPYI 718
V GL T Y F VRA+N G S+PS S P G R ++ + +
Sbjct: 582 VR--GLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLV 639
Query: 719 TFTDAV--NETTIMLKWMYIPASNNNTPIHGFYIYYRPTD--SDNDSDYKKDMVEGDKYW 774
+ V TT+ + W I G+ + YR T S D +
Sbjct: 640 RLHNPVVLTPTTVQVTW---TVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERS 696
Query: 775 HSISHLQPETSYDIKMQ-CFNE--GGESEFSNVMICE 808
+ +L+ +Y+IK++ FNE G +SE V E
Sbjct: 697 AVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTE 733
Score = 41.2 bits (95), Expect = 0.006
Identities = 24/90 (26%), Positives = 41/90 (45%), Gaps = 11/90 (12%)
Query: 322 PPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLIS------SQRLRLSRRA 375
PP + S +++ G+ L C+ G P P++ W ++ + + S R+ L +
Sbjct: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
Query: 376 LRVLSM-----GPEDEGVYQCMAENEVGSA 400
L L + DEG Y C+A N +G A
Sbjct: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEA 119
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 132 bits (331), Expect = 2e-30
Identities = 113/405 (27%), Positives = 180/405 (44%), Gaps = 41/405 (10%)
Query: 20 CLLLATAGCFADLNEVPQVTVQ-PASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKELNG 77
CLL+ +L E P +T Q P V P + L C P + W +G
Sbjct: 17 CLLIQIP---EELMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKP 73
Query: 78 SDDALGVLITH----GTLVITALNNHTVGRYQ----CVARMPAGAVASVPATVTLANLQD 129
++ LGV + G+ IT N++ R+Q C A G S +
Sbjct: 74 KEE-LGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPK 132
Query: 130 FKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIM-PSGNLQIV 188
+ + +EV+EG + V+ C+ P S ++ Y + + L + + M +GNL
Sbjct: 133 WPKETVKPVEVEEGESVVLPCNPPPSAEPLRI-YWMNSKILHIKQDERVTMGQNGNLYFA 191
Query: 189 NA-SQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTA---EAARIIYPPEAQT-IIVT 243
N + ++ Y C A+ P T+ + D LRV+ + + R+++P + + ++
Sbjct: 192 NVLTSDNHSDYICHAHFPGTRTIIQKEPID-LRVKATNSMIDRKPRLLFPTNSSSHLVAL 250
Query: 244 KGQSLILECVASGIPPPRVTWAK-------DGSSVTGYNKTRFLLSNLLIDTTSEEDSGT 296
+GQ L+LEC+A G P P + W + D + +NKT LL EED G
Sbjct: 251 QGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLK------VGEEDDGE 304
Query: 297 YRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLW 356
YRC+A+N +G A Y V V P + + G++A+L C+V+G P P V W
Sbjct: 305 YRCLAENSLGSARHA---YYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTW 361
Query: 357 LRNAVP---LISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVG 398
N +P L Q+ R+ R AL + ++ P D V QC A N G
Sbjct: 362 RINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHG 406
Score = 87.4 bits (215), Expect = 7e-17
Identities = 163/812 (20%), Positives = 292/812 (35%), Gaps = 126/812 (15%)
Query: 50 GGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVA 108
G ++L C+ E P + W + D + + TL + + G Y+C+A
Sbjct: 252 GQPLVLECIAEGFPTPTIKWLRPSGPMPA--DRVTYQNHNKTLQLLKVGEEDDGEYRCLA 309
Query: 109 RMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQE 168
G+ A H+ G TA + C + + P+ +V + +
Sbjct: 310 ENSLGSARHAYYVTVEAAPYWLHKPQSHLY--GPGETARLDCQV-QGRPQPEVTWRINGI 366
Query: 169 WLE--ASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTA 226
+E A Y I G L + N D + +C A N + + + V + A
Sbjct: 367 PVEELAKDQKYRIQ-RGALILSNVQPSDTMVTQCEARNRHGLLLANA----YIYVVQLPA 421
Query: 227 EAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN--L 284
+ I + QT + +G + L C A G P P V W + + ++ F +N L
Sbjct: 422 K----ILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTL 477
Query: 285 LIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTC 344
I D+G Y C+A N I+ N++V + ++T + G TC
Sbjct: 478 GIRDLQANDTGRYFCLAAN---DQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTC 534
Query: 345 EVRGNP--PPSVLWL---RNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGS 399
+ +P PS+ W R+ L S + + L + S+ D+G Y C+A E+
Sbjct: 535 QASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDV 594
Query: 400 AHAVVQLR-TSRPSITPRL----------------WQDAE----------LATGTPPVSP 432
+ QL P PRL W AE + ++P
Sbjct: 595 VESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAP 654
Query: 433 SKLGNPEQMLRGQPA--LPRPP-----------TSVGPASPQCPGE---KGQGAPAEAPI 476
K + ++ Q + L P GP P E + AP + P+
Sbjct: 655 EKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPV 714
Query: 477 ILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTL 536
+ ++T + + W+P AP + Y V+ R + W + + L +
Sbjct: 715 DVKG-EGNETTNMVITWKPLRWMDWNAPQVQYRVQWRP-QGTRGPWQEQIV--SDPFLVV 770
Query: 537 TRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSS 596
+ YE+++ A N G+G P+P++
Sbjct: 771 SNTSTFVPYEIKVQAVNSQGKG------------PEPQVTIGYS---------------- 802
Query: 597 QPDHGRLSPPEAPDRPTISTASETSVYVTWIP------RGN-GGFPIQSFRVEYKKLKKV 649
G P P+ I + ++V V W P +G+ G+ + +R ++
Sbjct: 803 ----GEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSK 858
Query: 650 GDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVY 709
+P + SV ++GL +SY V+A N G S P+ + S G
Sbjct: 859 RHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG----SGPASEFTFSTPEG--- 911
Query: 710 ERPVAG-PYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMV 768
V G P + + T+++L+W P ++N + G+ + Y P D ++
Sbjct: 912 ---VPGHPEALHLECQSNTSLLLRWQ--PPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLR 966
Query: 769 EGDKYWHSISHLQPETSYDIKMQCFNEGGESE 800
+ + H+++ L P Y ++Q + G E
Sbjct: 967 DPELRTHNLTDLSPHLRYRFQLQATTKEGPGE 998
Score = 65.1 bits (157), Expect = 4e-10
Identities = 65/241 (26%), Positives = 104/241 (43%), Gaps = 51/241 (21%)
Query: 189 NASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEA-QTIIVTKGQS 247
N +Q +G+Y+C A N + G++ +R A + +P E + + V +G+S
Sbjct: 98 NFAQRFQGIYRCFASNKL-------GTAMSHEIRLMAEGAPK--WPKETVKPVEVEEGES 148
Query: 248 LILECVASGIPPP-----RVTWA--------KDGSSVTGYNKTRFLLSNLLIDTTSEEDS 294
++L C PPP R+ W +D G N + + L D S+
Sbjct: 149 VVLPCN----PPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSD--- 201
Query: 295 GTYRCMADNGVGQPGAAVILY-----------NVQVFEPPEV---TMELSQLVIPWGQSA 340
Y C A PG I+ N + P + T S LV GQ
Sbjct: 202 --YICHAHF----PGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPL 255
Query: 341 KLTCEVRGNPPPSVLWLRNAVPLISSQ-RLRLSRRALRVLSMGPEDEGVYQCMAENEVGS 399
L C G P P++ WLR + P+ + + + + L++L +G ED+G Y+C+AEN +GS
Sbjct: 256 VLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGS 315
Query: 400 A 400
A
Sbjct: 316 A 316
Score = 62.4 bits (150), Expect = 2e-09
Identities = 78/350 (22%), Positives = 137/350 (39%), Gaps = 65/350 (18%)
Query: 469 GAPAEAP-IILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDW-TISG 526
G+P P ++LS + W P + + API Y ++ + + W ++
Sbjct: 605 GSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHN--APIEKYDIEFEDKEMAPEKWYSLGK 662
Query: 527 IPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRD 586
+P NQ TL +L P Y + A N G G+
Sbjct: 663 VPGNQTSTTL-KLSPYVHYTFRVTAINKYGPGEP-------------------------- 695
Query: 587 DPGASPQSSSQPDHGRLSPPEAPDRPTISTASE----TSVYVTWIPRG--NGGFPIQSFR 640
SP S + ++P AP++ + E T++ +TW P + P +R
Sbjct: 696 ----SPVSETV-----VTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYR 746
Query: 641 VEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYV 700
V+++ G W + P + ++ Y+ +V+A+N G+ P V
Sbjct: 747 VQWRPQGTRGPWQEQIVSDP----FLVVSNTSTFVPYEIKVQAVNSQGKGP-----EPQV 797
Query: 701 VSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDND 760
GYSG Y P A P + + +N + +++KW + + + G+ + Y S
Sbjct: 798 TIGYSGEDY--PQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRK 855
Query: 761 SDYK---KDMVEGDKYWHSI--SHLQPETSYDIKMQCFN---EGGESEFS 802
+ KD V S+ S L+P +SY +++Q FN G SEF+
Sbjct: 856 HSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFT 905
Score = 56.6 bits (135), Expect = 1e-07
Identities = 99/411 (24%), Positives = 156/411 (37%), Gaps = 64/411 (15%)
Query: 618 SETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSY 677
+++ V V+W P + PI+ + +E++ + + + +P ++ S + L Y
Sbjct: 622 TQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLK-LSPYVHY 680
Query: 678 KFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNE----TTIMLKW 733
FRV A+N G EPS S V P A P D E T +++ W
Sbjct: 681 TFRVTAINKYGPGEPSPVSETVVT----------PEAAPEKNPVDVKGEGNETTNMVITW 730
Query: 734 MYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCF 793
+ + N P + + +RP + ++ + D + +S+ Y+IK+Q
Sbjct: 731 KPLRWMDWNAPQVQYRVQWRPQGTRGP---WQEQIVSDPFL-VVSNTSTFVPYEIKVQAV 786
Query: 794 NEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIERPVGTGAMVA-RSSD 852
N G+ V I G G P + P E IE + +V R D
Sbjct: 787 NSQGKGPEPQVTI---------GYSGEDYPQAI-----PELEGIEILNSSAVLVKWRPVD 832
Query: 853 LPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALPPSCPYTMVPLGGLP 912
L V G + VT+ WR S++KH+ + P+ T V L GL
Sbjct: 833 L-----AQVKGHLRGYNVTY-----WREGSQRKHSKRHIHKDHVVVPA-NTTSVILSGLR 881
Query: 913 GHQASGQPYLSGISGRACANGIHMNRGCPSAAVGYPGMKPQQHCPGELQQQSDTSSLLR- 971
+ +S + +GR P G+P L+ QS+TS LLR
Sbjct: 882 PY-SSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEAL-------HLECQSNTSLLLRW 933
Query: 972 ---QTHLG--NGYDPQSHQITRGPKSSPDEGSFLYTLPDDSTHQL--LQPH 1015
+H G GY H + G K + SF P+ TH L L PH
Sbjct: 934 QPPLSHNGVLTGYVLSYHPLDEGGKG---QLSFNLRDPELRTHNLTDLSPH 981
Score = 47.0 bits (110), Expect = 1e-04
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 3/89 (3%)
Query: 32 LNEVPQVTVQPASTVQKPGGTVILGCVVE-PPRM--NVTWRLNGKELNGSDDALGVLITH 88
+ + Q+T P ST++K G V C P + ++TWR +G++L D+ I
Sbjct: 509 VKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIED 568
Query: 89 GTLVITALNNHTVGRYQCVARMPAGAVAS 117
G LVI +L+ G Y CVA V S
Sbjct: 569 GRLVIHSLDYSDQGNYSCVASTELDVVES 597
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 130 bits (326), Expect = 9e-30
Identities = 109/391 (27%), Positives = 174/391 (44%), Gaps = 38/391 (9%)
Query: 34 EVPQVTVQ-PASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDDALGVLITH--- 88
E P +T Q P V P + L C P + W +G ++ LGV +
Sbjct: 33 EPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEE-LGVTVYQSPH 91
Query: 89 -GTLVITALNNHTVGRYQ----CVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEG 143
G+ IT N++ R+Q C A G S + + + +EV+EG
Sbjct: 92 SGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEG 151
Query: 144 NTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIM-PSGNLQIVNA-SQEDEGMYKCA 201
+ V+ C+ P S ++ Y + + L + + M +GNL N + ++ Y C
Sbjct: 152 ESVVLPCNPPPSAEPLRI-YWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICH 210
Query: 202 AYNPVTQEVKTSGSSDRLRVRRSTA---EAARIIYPPEAQT-IIVTKGQSLILECVASGI 257
A+ P T+ + D LRV+ + + R+++P + + ++ +GQ L+LEC+A G
Sbjct: 211 AHFPGTRTIIQKEPID-LRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGF 269
Query: 258 PPPRVTWAK-------DGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGA 310
P P + W + D + +NKT LL EED G YRC+A+N +G
Sbjct: 270 PTPTIKWLRPSGPMPADRVTYQNHNKTLQLLK------VGEEDDGEYRCLAENSLGSARH 323
Query: 311 AVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVP---LISSQ 367
A Y V V P + + G++A+L C+V+G P P V W N +P L Q
Sbjct: 324 A---YYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQ 380
Query: 368 RLRLSRRALRVLSMGPEDEGVYQCMAENEVG 398
+ R+ R AL + ++ P D V QC A N G
Sbjct: 381 KYRIQRGALILSNVQPSDTMVTQCEARNRHG 411
Score = 87.4 bits (215), Expect = 7e-17
Identities = 163/812 (20%), Positives = 292/812 (35%), Gaps = 126/812 (15%)
Query: 50 GGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVA 108
G ++L C+ E P + W + D + + TL + + G Y+C+A
Sbjct: 257 GQPLVLECIAEGFPTPTIKWLRPSGPMPA--DRVTYQNHNKTLQLLKVGEEDDGEYRCLA 314
Query: 109 RMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQE 168
G+ A H+ G TA + C + + P+ +V + +
Sbjct: 315 ENSLGSARHAYYVTVEAAPYWLHKPQSHLY--GPGETARLDCQV-QGRPQPEVTWRINGI 371
Query: 169 WLE--ASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTA 226
+E A Y I G L + N D + +C A N + + + V + A
Sbjct: 372 PVEELAKDQKYRIQ-RGALILSNVQPSDTMVTQCEARNRHGLLLANA----YIYVVQLPA 426
Query: 227 EAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN--L 284
+ I + QT + +G + L C A G P P V W + + ++ F +N L
Sbjct: 427 K----ILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTL 482
Query: 285 LIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTC 344
I D+G Y C+A N I+ N++V + ++T + G TC
Sbjct: 483 GIRDLQANDTGRYFCLAAN---DQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTC 539
Query: 345 EVRGNP--PPSVLWL---RNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGS 399
+ +P PS+ W R+ L S + + L + S+ D+G Y C+A E+
Sbjct: 540 QASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDV 599
Query: 400 AHAVVQLR-TSRPSITPRL----------------WQDAE----------LATGTPPVSP 432
+ QL P PRL W AE + ++P
Sbjct: 600 VESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAP 659
Query: 433 SKLGNPEQMLRGQPA--LPRPP-----------TSVGPASPQCPGE---KGQGAPAEAPI 476
K + ++ Q + L P GP P E + AP + P+
Sbjct: 660 EKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPV 719
Query: 477 ILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTL 536
+ ++T + + W+P AP + Y V+ R + W + + L +
Sbjct: 720 DVKG-EGNETTNMVITWKPLRWMDWNAPQVQYRVQWRP-QGTRGPWQEQIV--SDPFLVV 775
Query: 537 TRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSS 596
+ YE+++ A N G+G P+P++
Sbjct: 776 SNTSTFVPYEIKVQAVNSQGKG------------PEPQVTIGYS---------------- 807
Query: 597 QPDHGRLSPPEAPDRPTISTASETSVYVTWIP------RGN-GGFPIQSFRVEYKKLKKV 649
G P P+ I + ++V V W P +G+ G+ + +R ++
Sbjct: 808 ----GEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSK 863
Query: 650 GDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVY 709
+P + SV ++GL +SY V+A N G S P+ + S G
Sbjct: 864 RHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG----SGPASEFTFSTPEG--- 916
Query: 710 ERPVAG-PYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMV 768
V G P + + T+++L+W P ++N + G+ + Y P D ++
Sbjct: 917 ---VPGHPEALHLECQSNTSLLLRWQ--PPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLR 971
Query: 769 EGDKYWHSISHLQPETSYDIKMQCFNEGGESE 800
+ + H+++ L P Y ++Q + G E
Sbjct: 972 DPELRTHNLTDLSPHLRYRFQLQATTKEGPGE 1003
Score = 65.1 bits (157), Expect = 4e-10
Identities = 65/241 (26%), Positives = 104/241 (43%), Gaps = 51/241 (21%)
Query: 189 NASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEA-QTIIVTKGQS 247
N +Q +G+Y+C A N + G++ +R A + +P E + + V +G+S
Sbjct: 103 NFAQRFQGIYRCFASNKL-------GTAMSHEIRLMAEGAPK--WPKETVKPVEVEEGES 153
Query: 248 LILECVASGIPPP-----RVTWA--------KDGSSVTGYNKTRFLLSNLLIDTTSEEDS 294
++L C PPP R+ W +D G N + + L D S+
Sbjct: 154 VVLPCN----PPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSD--- 206
Query: 295 GTYRCMADNGVGQPGAAVILY-----------NVQVFEPPEV---TMELSQLVIPWGQSA 340
Y C A PG I+ N + P + T S LV GQ
Sbjct: 207 --YICHAHF----PGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPL 260
Query: 341 KLTCEVRGNPPPSVLWLRNAVPLISSQ-RLRLSRRALRVLSMGPEDEGVYQCMAENEVGS 399
L C G P P++ WLR + P+ + + + + L++L +G ED+G Y+C+AEN +GS
Sbjct: 261 VLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGS 320
Query: 400 A 400
A
Sbjct: 321 A 321
Score = 62.4 bits (150), Expect = 2e-09
Identities = 78/350 (22%), Positives = 137/350 (39%), Gaps = 65/350 (18%)
Query: 469 GAPAEAP-IILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDW-TISG 526
G+P P ++LS + W P + + API Y ++ + + W ++
Sbjct: 610 GSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHN--APIEKYDIEFEDKEMAPEKWYSLGK 667
Query: 527 IPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRD 586
+P NQ TL +L P Y + A N G G+
Sbjct: 668 VPGNQTSTTL-KLSPYVHYTFRVTAINKYGPGEP-------------------------- 700
Query: 587 DPGASPQSSSQPDHGRLSPPEAPDRPTISTASE----TSVYVTWIPRG--NGGFPIQSFR 640
SP S + ++P AP++ + E T++ +TW P + P +R
Sbjct: 701 ----SPVSETV-----VTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYR 751
Query: 641 VEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYV 700
V+++ G W + P + ++ Y+ +V+A+N G+ P V
Sbjct: 752 VQWRPQGTRGPWQEQIVSDP----FLVVSNTSTFVPYEIKVQAVNSQGKGP-----EPQV 802
Query: 701 VSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDND 760
GYSG Y P A P + + +N + +++KW + + + G+ + Y S
Sbjct: 803 TIGYSGEDY--PQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRK 860
Query: 761 SDYK---KDMVEGDKYWHSI--SHLQPETSYDIKMQCFN---EGGESEFS 802
+ KD V S+ S L+P +SY +++Q FN G SEF+
Sbjct: 861 HSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFT 910
Score = 56.6 bits (135), Expect = 1e-07
Identities = 99/411 (24%), Positives = 156/411 (37%), Gaps = 64/411 (15%)
Query: 618 SETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSY 677
+++ V V+W P + PI+ + +E++ + + + +P ++ S + L Y
Sbjct: 627 TQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLK-LSPYVHY 685
Query: 678 KFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNE----TTIMLKW 733
FRV A+N G EPS S V P A P D E T +++ W
Sbjct: 686 TFRVTAINKYGPGEPSPVSETVVT----------PEAAPEKNPVDVKGEGNETTNMVITW 735
Query: 734 MYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCF 793
+ + N P + + +RP + ++ + D + +S+ Y+IK+Q
Sbjct: 736 KPLRWMDWNAPQVQYRVQWRPQGTRGP---WQEQIVSDPFL-VVSNTSTFVPYEIKVQAV 791
Query: 794 NEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIERPVGTGAMVA-RSSD 852
N G+ V I G G P + P E IE + +V R D
Sbjct: 792 NSQGKGPEPQVTI---------GYSGEDYPQAI-----PELEGIEILNSSAVLVKWRPVD 837
Query: 853 LPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALPPSCPYTMVPLGGLP 912
L V G + VT+ WR S++KH+ + P+ T V L GL
Sbjct: 838 L-----AQVKGHLRGYNVTY-----WREGSQRKHSKRHIHKDHVVVPA-NTTSVILSGLR 886
Query: 913 GHQASGQPYLSGISGRACANGIHMNRGCPSAAVGYPGMKPQQHCPGELQQQSDTSSLLR- 971
+ +S + +GR P G+P L+ QS+TS LLR
Sbjct: 887 PY-SSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEAL-------HLECQSNTSLLLRW 938
Query: 972 ---QTHLG--NGYDPQSHQITRGPKSSPDEGSFLYTLPDDSTHQL--LQPH 1015
+H G GY H + G K + SF P+ TH L L PH
Sbjct: 939 QPPLSHNGVLTGYVLSYHPLDEGGKG---QLSFNLRDPELRTHNLTDLSPH 986
Score = 47.0 bits (110), Expect = 1e-04
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 3/89 (3%)
Query: 32 LNEVPQVTVQPASTVQKPGGTVILGCVVE-PPRM--NVTWRLNGKELNGSDDALGVLITH 88
+ + Q+T P ST++K G V C P + ++TWR +G++L D+ I
Sbjct: 514 VKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIED 573
Query: 89 GTLVITALNNHTVGRYQCVARMPAGAVAS 117
G LVI +L+ G Y CVA V S
Sbjct: 574 GRLVIHSLDYSDQGNYSCVASTELDVVES 602
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 130 bits (326), Expect = 9e-30
Identities = 109/391 (27%), Positives = 174/391 (44%), Gaps = 38/391 (9%)
Query: 34 EVPQVTVQ-PASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDDALGVLITH--- 88
E P +T Q P V P + L C P + W +G ++ LGV +
Sbjct: 33 EPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEE-LGVTVYQSPH 91
Query: 89 -GTLVITALNNHTVGRYQ----CVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEG 143
G+ IT N++ R+Q C A G S + + + +EV+EG
Sbjct: 92 SGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEG 151
Query: 144 NTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIM-PSGNLQIVNA-SQEDEGMYKCA 201
+ V+ C+ P S ++ Y + + L + + M +GNL N + ++ Y C
Sbjct: 152 ESVVLPCNPPPSAEPLRI-YWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICH 210
Query: 202 AYNPVTQEVKTSGSSDRLRVRRSTA---EAARIIYPPEAQT-IIVTKGQSLILECVASGI 257
A+ P T+ + D LRV+ + + R+++P + + ++ +GQ L+LEC+A G
Sbjct: 211 AHFPGTRTIIQKEPID-LRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGF 269
Query: 258 PPPRVTWAK-------DGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGA 310
P P + W + D + +NKT LL EED G YRC+A+N +G
Sbjct: 270 PTPTIKWLRPSGPMPADRVTYQNHNKTLQLLK------VGEEDDGEYRCLAENSLGSARH 323
Query: 311 AVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVP---LISSQ 367
A Y V V P + + G++A+L C+V+G P P V W N +P L Q
Sbjct: 324 A---YYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQ 380
Query: 368 RLRLSRRALRVLSMGPEDEGVYQCMAENEVG 398
+ R+ R AL + ++ P D V QC A N G
Sbjct: 381 KYRIQRGALILSNVQPSDTMVTQCEARNRHG 411
Score = 87.4 bits (215), Expect = 7e-17
Identities = 163/812 (20%), Positives = 292/812 (35%), Gaps = 126/812 (15%)
Query: 50 GGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVA 108
G ++L C+ E P + W + D + + TL + + G Y+C+A
Sbjct: 257 GQPLVLECIAEGFPTPTIKWLRPSGPMPA--DRVTYQNHNKTLQLLKVGEEDDGEYRCLA 314
Query: 109 RMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQE 168
G+ A H+ G TA + C + + P+ +V + +
Sbjct: 315 ENSLGSARHAYYVTVEAAPYWLHKPQSHLY--GPGETARLDCQV-QGRPQPEVTWRINGI 371
Query: 169 WLE--ASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTA 226
+E A Y I G L + N D + +C A N + + + V + A
Sbjct: 372 PVEELAKDQKYRIQ-RGALILSNVQPSDTMVTQCEARNRHGLLLANA----YIYVVQLPA 426
Query: 227 EAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN--L 284
+ I + QT + +G + L C A G P P V W + + ++ F +N L
Sbjct: 427 K----ILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTL 482
Query: 285 LIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTC 344
I D+G Y C+A N I+ N++V + ++T + G TC
Sbjct: 483 GIRDLQANDTGRYFCLAAN---DQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTC 539
Query: 345 EVRGNP--PPSVLWL---RNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGS 399
+ +P PS+ W R+ L S + + L + S+ D+G Y C+A E+
Sbjct: 540 QASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDV 599
Query: 400 AHAVVQLR-TSRPSITPRL----------------WQDAE----------LATGTPPVSP 432
+ QL P PRL W AE + ++P
Sbjct: 600 VESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAP 659
Query: 433 SKLGNPEQMLRGQPA--LPRPP-----------TSVGPASPQCPGE---KGQGAPAEAPI 476
K + ++ Q + L P GP P E + AP + P+
Sbjct: 660 EKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPV 719
Query: 477 ILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTL 536
+ ++T + + W+P AP + Y V+ R + W + + L +
Sbjct: 720 DVKG-EGNETTNMVITWKPLRWMDWNAPQVQYRVQWRP-QGTRGPWQEQIV--SDPFLVV 775
Query: 537 TRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSS 596
+ YE+++ A N G+G P+P++
Sbjct: 776 SNTSTFVPYEIKVQAVNSQGKG------------PEPQVTIGYS---------------- 807
Query: 597 QPDHGRLSPPEAPDRPTISTASETSVYVTWIP------RGN-GGFPIQSFRVEYKKLKKV 649
G P P+ I + ++V V W P +G+ G+ + +R ++
Sbjct: 808 ----GEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSK 863
Query: 650 GDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVY 709
+P + SV ++GL +SY V+A N G S P+ + S G
Sbjct: 864 RHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG----SGPASEFTFSTPEG--- 916
Query: 710 ERPVAG-PYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMV 768
V G P + + T+++L+W P ++N + G+ + Y P D ++
Sbjct: 917 ---VPGHPEALHLECQSNTSLLLRWQ--PPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLR 971
Query: 769 EGDKYWHSISHLQPETSYDIKMQCFNEGGESE 800
+ + H+++ L P Y ++Q + G E
Sbjct: 972 DPELRTHNLTDLSPHLRYRFQLQATTKEGPGE 1003
Score = 65.1 bits (157), Expect = 4e-10
Identities = 65/241 (26%), Positives = 104/241 (43%), Gaps = 51/241 (21%)
Query: 189 NASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEA-QTIIVTKGQS 247
N +Q +G+Y+C A N + G++ +R A + +P E + + V +G+S
Sbjct: 103 NFAQRFQGIYRCFASNKL-------GTAMSHEIRLMAEGAPK--WPKETVKPVEVEEGES 153
Query: 248 LILECVASGIPPP-----RVTWA--------KDGSSVTGYNKTRFLLSNLLIDTTSEEDS 294
++L C PPP R+ W +D G N + + L D S+
Sbjct: 154 VVLPCN----PPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSD--- 206
Query: 295 GTYRCMADNGVGQPGAAVILY-----------NVQVFEPPEV---TMELSQLVIPWGQSA 340
Y C A PG I+ N + P + T S LV GQ
Sbjct: 207 --YICHAHF----PGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPL 260
Query: 341 KLTCEVRGNPPPSVLWLRNAVPLISSQ-RLRLSRRALRVLSMGPEDEGVYQCMAENEVGS 399
L C G P P++ WLR + P+ + + + + L++L +G ED+G Y+C+AEN +GS
Sbjct: 261 VLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGS 320
Query: 400 A 400
A
Sbjct: 321 A 321
Score = 62.4 bits (150), Expect = 2e-09
Identities = 78/350 (22%), Positives = 137/350 (39%), Gaps = 65/350 (18%)
Query: 469 GAPAEAP-IILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDW-TISG 526
G+P P ++LS + W P + + API Y ++ + + W ++
Sbjct: 610 GSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHN--APIEKYDIEFEDKEMAPEKWYSLGK 667
Query: 527 IPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRD 586
+P NQ TL +L P Y + A N G G+
Sbjct: 668 VPGNQTSTTL-KLSPYVHYTFRVTAINKYGPGEP-------------------------- 700
Query: 587 DPGASPQSSSQPDHGRLSPPEAPDRPTISTASE----TSVYVTWIPRG--NGGFPIQSFR 640
SP S + ++P AP++ + E T++ +TW P + P +R
Sbjct: 701 ----SPVSETV-----VTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYR 751
Query: 641 VEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYV 700
V+++ G W + P + ++ Y+ +V+A+N G+ P V
Sbjct: 752 VQWRPQGTRGPWQEQIVSDP----FLVVSNTSTFVPYEIKVQAVNSQGKGP-----EPQV 802
Query: 701 VSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDND 760
GYSG Y P A P + + +N + +++KW + + + G+ + Y S
Sbjct: 803 TIGYSGEDY--PQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRK 860
Query: 761 SDYK---KDMVEGDKYWHSI--SHLQPETSYDIKMQCFN---EGGESEFS 802
+ KD V S+ S L+P +SY +++Q FN G SEF+
Sbjct: 861 HSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFT 910
Score = 56.6 bits (135), Expect = 1e-07
Identities = 99/411 (24%), Positives = 156/411 (37%), Gaps = 64/411 (15%)
Query: 618 SETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSY 677
+++ V V+W P + PI+ + +E++ + + + +P ++ S + L Y
Sbjct: 627 TQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLK-LSPYVHY 685
Query: 678 KFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNE----TTIMLKW 733
FRV A+N G EPS S V P A P D E T +++ W
Sbjct: 686 TFRVTAINKYGPGEPSPVSETVVT----------PEAAPEKNPVDVKGEGNETTNMVITW 735
Query: 734 MYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCF 793
+ + N P + + +RP + ++ + D + +S+ Y+IK+Q
Sbjct: 736 KPLRWMDWNAPQVQYRVQWRPQGTRGP---WQEQIVSDPFL-VVSNTSTFVPYEIKVQAV 791
Query: 794 NEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIERPVGTGAMVA-RSSD 852
N G+ V I G G P + P E IE + +V R D
Sbjct: 792 NSQGKGPEPQVTI---------GYSGEDYPQAI-----PELEGIEILNSSAVLVKWRPVD 837
Query: 853 LPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALPPSCPYTMVPLGGLP 912
L V G + VT+ WR S++KH+ + P+ T V L GL
Sbjct: 838 L-----AQVKGHLRGYNVTY-----WREGSQRKHSKRHIHKDHVVVPA-NTTSVILSGLR 886
Query: 913 GHQASGQPYLSGISGRACANGIHMNRGCPSAAVGYPGMKPQQHCPGELQQQSDTSSLLR- 971
+ +S + +GR P G+P L+ QS+TS LLR
Sbjct: 887 PY-SSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEAL-------HLECQSNTSLLLRW 938
Query: 972 ---QTHLG--NGYDPQSHQITRGPKSSPDEGSFLYTLPDDSTHQL--LQPH 1015
+H G GY H + G K + SF P+ TH L L PH
Sbjct: 939 QPPLSHNGVLTGYVLSYHPLDEGGKG---QLSFNLRDPELRTHNLTDLSPH 986
Score = 47.0 bits (110), Expect = 1e-04
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 3/89 (3%)
Query: 32 LNEVPQVTVQPASTVQKPGGTVILGCVVE-PPRM--NVTWRLNGKELNGSDDALGVLITH 88
+ + Q+T P ST++K G V C P + ++TWR +G++L D+ I
Sbjct: 514 VKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIED 573
Query: 89 GTLVITALNNHTVGRYQCVARMPAGAVAS 117
G LVI +L+ G Y CVA V S
Sbjct: 574 GRLVIHSLDYSDQGNYSCVASTELDVVES 602
>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
sapiens]
Length = 761
Score = 127 bits (320), Expect = 4e-29
Identities = 164/721 (22%), Positives = 267/721 (37%), Gaps = 88/721 (12%)
Query: 37 QVTVQPASTVQKPGGTVILGCVV--EPPRMNVTW-RLNGKELNGSDDALGVLI---THGT 90
QV + P+ G + C V + +++W NG++L + + V+ + T
Sbjct: 21 QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSST 80
Query: 91 LVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIAC 150
L I N G Y+CV G+ + V + FK + E EG AVI C
Sbjct: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFK-NAPTPQEFREGEDAVIVC 139
Query: 151 HLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEV 210
+ S P + ++ + ++++ + LQI + DEG Y+C E+
Sbjct: 140 DVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI 199
Query: 211 KTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSS 270
+ V + I+ GQS+ L C A G P P ++W KDG
Sbjct: 200 NFKDIQVIVNVPPTIQARQNIV------NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQ 253
Query: 271 VTGYNKTRFLL-----SNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEV 325
+ + S L I + D Y C+A+N G+ A + +++VF P++
Sbjct: 254 IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI---HLKVFAKPKI 310
Query: 326 TMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRR----------A 375
T +Q + + LTCE G+P PS+ W R + ISS+ L +
Sbjct: 311 TYVENQTAMELEEQVTLTCEASGDPIPSITW-RTSTRNISSEEKTLDGHMVVRSHARVSS 369
Query: 376 LRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRT--------------------------- 408
L + S+ D G Y C A N +G + L
Sbjct: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVF 429
Query: 409 SRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQ 468
+ PS T ++D +L + + P P G + GQ
Sbjct: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASY--LEVTPDSENDFGNYNCTAVNRIGQ 487
Query: 469 GA------PAEAPIILSSPRTSKTDSYE---LVWRPRHEGSGRAPILYYVVKHRKVTNS- 518
+ A+ P SSP + + Y V E +G PIL Y + R V
Sbjct: 488 ESLEFILVQADTP---SSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEV 544
Query: 519 -SDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQ-TAMVTFRTG--RRPKPE 574
W + + + +T+ L P + Y V +AA N G G+ +A F+T P P
Sbjct: 545 WHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPP 604
Query: 575 IMASKEQQIQRDDPGAS----PQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRG 630
AS + P + ++++P G P AP S+ V I +
Sbjct: 605 ASASSSTPVPLSPPDTTWPLPALATTEPAKGE---PSAPKLEGQMGEDGNSIKVNLIKQD 661
Query: 631 NGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGES 690
+GG PI+ + V Y+ L +W +P V + L+ Y+ V A N G+S
Sbjct: 662 DGGSPIRHYLVRYRALS--SEW-KPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 718
Query: 691 E 691
+
Sbjct: 719 K 719
Score = 75.9 bits (185), Expect = 2e-13
Identities = 116/555 (20%), Positives = 208/555 (37%), Gaps = 84/555 (15%)
Query: 50 GGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGT--LVITALNNHTVGRYQC 106
G +V L C E P ++W +G+++ +D + + + L I ++ + Y C
Sbjct: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
Query: 107 VARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLP-ESHPKAQVRYSV 165
+A AG + A + ++ Q +E++E T + C + P R S
Sbjct: 288 IAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVT--LTCEASGDPIPSITWRTST 345
Query: 166 KQ-EWLEASRGNYLIMPS----GNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLR 220
+ E + ++++ S +L + + D G Y C A N + Q+
Sbjct: 346 RNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD----------- 394
Query: 221 VRRSTAEAARIIYPPEAQ---TIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKT 277
S + + Y P+ Q + +G + + C P ++W +DG + N +
Sbjct: 395 ---SQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYS 451
Query: 278 RFLLSN------LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQ 331
+ N L + SE D G Y C A N +GQ IL P +
Sbjct: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQ---- 507
Query: 332 LVIPWGQSAKLTC---EVRGNPP---PSVLWLRNAVPLISSQRLRLSRRALR----VLSM 381
V P+ +A++ E G P W + S+ ++ ++ +
Sbjct: 508 -VEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGL 566
Query: 382 GPEDEGVYQCMAEN--EVGSAHAVVQLRTSRPSITPRLWQDAELATGTP-PVSPSKLGNP 438
PE + A N +G A + +T P A ++ TP P+SP P
Sbjct: 567 KPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPP---PPASASSSTPVPLSPPDTTWP 623
Query: 439 EQMLRGQPALPRPPTSVG-PASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRH 497
PAL + G P++P+ G+ G+ D +
Sbjct: 624 ------LPALATTEPAKGEPSAPKLEGQMGE------------------DGNSIKVNLIK 659
Query: 498 EGSGRAPILYYVVKHRKVTNSSDDWTIS-GIPANQHRLTLTRLDPGSLYEVEMAAYNCAG 556
+ G +PI +Y+V++R + S +W +P+ + L LD + YEV + A N G
Sbjct: 660 QDDGGSPIRHYLVRYRAL---SSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 716
Query: 557 EGQTAMVTFRTGRRP 571
+ + A FRT +P
Sbjct: 717 KSKAAHFVFRTSAQP 731
Score = 36.2 bits (82), Expect = 0.18
Identities = 28/95 (29%), Positives = 42/95 (44%), Gaps = 7/95 (7%)
Query: 606 PEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLS 665
P +P + S T+ P GG PI ++ E++ VG+ + + S
Sbjct: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRA---VGEEVWHSKWYDAKEAS 556
Query: 666 VE----ITGLEKGTSYKFRVRALNMLGESEPSAPS 696
+E I GL+ T+Y R+ ALN G E SA S
Sbjct: 557 MEGIVTIVGLKPETTYAVRLAALNGKGLGEISAAS 591
Score = 32.7 bits (73), Expect = 2.0
Identities = 26/90 (28%), Positives = 35/90 (38%), Gaps = 23/90 (25%)
Query: 770 GDKYWHS---------------ISHLQPETSYDIKMQCFNEGGESEFSNVMICETK---- 810
G++ WHS I L+PET+Y +++ N G E S +T+
Sbjct: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHS 600
Query: 811 ----ARKSSGQPGRLPPPTLAPPQPPLPET 836
A SS P L PP P P L T
Sbjct: 601 PPPPASASSSTPVPLSPPDTTWPLPALATT 630
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 127 bits (319), Expect = 6e-29
Identities = 102/340 (30%), Positives = 155/340 (45%), Gaps = 21/340 (6%)
Query: 95 ALNNHTVGRYQCV--ARMPAGAVASVPATVTLANLQDFKLDVQ-HVIEVDEGNTAVIACH 151
A + HT C R+ AVASV TV N Q ++ + +EV GNT C
Sbjct: 199 AQHGHTQAAATCEYPRRLHGRAVASV--TVEEFNCQSPRITFEPQDVEVPSGNTVYFTCR 256
Query: 152 LPESHPKAQVRYSVKQEWLEASRGNYL-IMPSGNLQIVNASQEDEGMYKCAAYNPVTQEV 210
E +PK ++ + L+ L + G L I N + D+G+Y+C A N E
Sbjct: 257 A-EGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAG-EA 314
Query: 211 KTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSS 270
KT S LR A+ + +I P + + +I G S LEC+A+G P P +TW +D
Sbjct: 315 KTQ--SAMLRYSSLPAKPSFVIQPQDTEVLI---GTSTTLECMATGHPHPLITWTRDNGL 369
Query: 271 VTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELS 330
++ S L + ++ D G + C A+N G AA N+ V PP+ T+
Sbjct: 370 ELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAA---NIIVQAPPQFTVTPK 426
Query: 331 QLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPL-ISSQRLRLSRRALRVLSMGPEDEGVY 389
V+ + + CE GNPPP ++W + L + Q LS LR+ D+G Y
Sbjct: 427 DQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQY 486
Query: 390 QCMAENEVGSAHAVVQLRTSRP---SITPRLWQDAELATG 426
+C A + +G VQL T +P ++ +L QD + G
Sbjct: 487 ECQAVSSLGVKKVSVQL-TVKPKALAVFTQLPQDTSVEVG 525
Score = 118 bits (295), Expect = 4e-26
Identities = 100/381 (26%), Positives = 156/381 (40%), Gaps = 41/381 (10%)
Query: 36 PQVTVQPASTVQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVIT 94
P++T +P G TV C E P+ + W N L+ DD + GTL+I
Sbjct: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
Query: 95 ALNNHTVGRYQCVARMPAGAVASVPATVTLANL---QDFKLDVQHVIEVDEGNTAVIACH 151
G YQC+AR AG + A + ++L F + Q EV G + + C
Sbjct: 294 NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDT-EVLIGTSTTLEC- 351
Query: 152 LPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVK 211
+ HP + ++ + LE ++ SG L + N +Q D G + C A N
Sbjct: 352 MATGHPHPLITWT-RDNGLELDGSRHVATSSG-LYLQNITQRDHGRFTCHANNS------ 403
Query: 212 TSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILE------CVASGIPPPRVTWA 265
+ AA II Q + K Q ++ E C A G PPP + W
Sbjct: 404 ----------HGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWT 453
Query: 266 KDGSSVTGYNKTRFLLSNLL-IDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPE 324
K G + + L S L ID ++ D G Y C A + +G V +VQ+ P+
Sbjct: 454 KTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLG-----VKKVSVQLTVKPK 508
Query: 325 VTMELSQL----VIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL-SRRALRVL 379
+QL + G++ ++C +G P P + W + V + S + + L +
Sbjct: 509 ALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIY 568
Query: 380 SMGPEDEGVYQCMAENEVGSA 400
G D+G Y+C+A N G A
Sbjct: 569 DAGFPDQGRYECVARNSFGLA 589
Score = 62.0 bits (149), Expect = 3e-09
Identities = 42/128 (32%), Positives = 58/128 (45%), Gaps = 9/128 (7%)
Query: 309 GAAVILYNVQVF--EPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRN--AVPLI 364
G AV V+ F + P +T E + +P G + TC GNP P ++W+ N ++ L
Sbjct: 218 GRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE 277
Query: 365 SSQRLRL-SRRALRVLSMGPEDEGVYQCMAENEVGSAHA-VVQLRTSRPSITPRLW---Q 419
RL + L + + D+GVYQCMA N G A LR S P Q
Sbjct: 278 DDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQ 337
Query: 420 DAELATGT 427
D E+ GT
Sbjct: 338 DTEVLIGT 345
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 122 bits (307), Expect = 1e-27
Identities = 101/368 (27%), Positives = 160/368 (43%), Gaps = 24/368 (6%)
Query: 53 VILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALN-NHTVGRYQCVARM 110
VIL C P + W+ NG +++ + + + G+L I + + + +G YQC+A
Sbjct: 46 VILNCAANGYPSPHYRWKQNGTDIDFTM-SYHYRLDGGSLAINSPHTDQDIGMYQCLATN 104
Query: 111 PAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWL 170
G + S A + A ++DF+ + + V EG V+ C P ++ L
Sbjct: 105 LLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPL 164
Query: 171 EASRGN--YLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEA 228
N ++ +GNL I D G Y C N Q G L V+R+
Sbjct: 165 YVQEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQR-SVQGPPTPL-VQRTDGVM 222
Query: 229 ARIIYPPEAQ-----TIIVTKGQSLILECVASGIPPPRVTWAK-DGSSVTG---YNKTRF 279
Y P+ + TI K S+ LEC A G P P ++W + DGS + G Y+K++
Sbjct: 223 GE--YEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQA 280
Query: 280 LLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQS 339
+L I +ED G Y C+A N G+ A L + PPE ++ + +
Sbjct: 281 ILE---IPNFQQEDEGFYECIASNLRGRNLAKGQLI---FYAPPEWEQKIQNTHLSIYDN 334
Query: 340 AKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGS 399
C+ G P P WL+N L +R+++ L + + D GVYQC AEN+
Sbjct: 335 LLWECKASGKPNPWYTWLKNGERLNPEERIQIENGTLIITMLNVSDSGVYQCAAENKYQI 394
Query: 400 AHAVVQLR 407
+A +LR
Sbjct: 395 IYANAELR 402
Score = 96.3 bits (238), Expect = 1e-19
Identities = 180/763 (23%), Positives = 282/763 (36%), Gaps = 153/763 (20%)
Query: 67 TWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLAN 126
TW NG+ LN + + I +GTL+IT LN G YQC A + + LA+
Sbjct: 350 TWLKNGERLNPEER---IQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLAS 406
Query: 127 LQDF-KLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNL 185
DF K V+ V G VI C P + P+A + + E L S+ +L + G+L
Sbjct: 407 APDFSKSPVKKKSFVQVGGDIVIGCK-PNAFPRAAISWKRGTETLRQSKRIFL-LEDGSL 464
Query: 186 QIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKG 245
+I N ++ D G Y C A T + T+ ++ L V+ T I PP VT G
Sbjct: 465 KIYNITRSDAGSYTCIA----TNQFGTAKNTGSLIVKERTV----ITVPPSKMD--VTVG 514
Query: 246 QSLILECVASGIPPPRV--TWAKDGSSVTGYNKTRFL-------LSNLLIDTTSEEDSGT 296
+S++L C S P V W +G + + +L+I SG
Sbjct: 515 ESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGK 574
Query: 297 YRCMADNGV------------GQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTC 344
Y C + G PG +VQV + T +LS P S
Sbjct: 575 YLCTVQTTLESLSAVADIIVRGPPGPP---EDVQVEDISSTTSQLSWRAGPDNNSPIQIF 631
Query: 345 EVRGNPPPSVLWLRNA-VPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAV 403
++ P SV W A VP I L V+ + P E ++ +A N +G
Sbjct: 632 TIQTRTPFSVGWQAVATVPEI----LNGKTYNATVVGLSPWVEYEFRVVAGNSIG----- 682
Query: 404 VQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCP 463
G P P ++LR + ++P V P +
Sbjct: 683 ---------------------IGEP-------SEPSELLRTKASVP----VVAPVNI--- 707
Query: 464 GEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWT 523
G G+ +E I ++E + G G Y++ R V S W+
Sbjct: 708 -HGGGGSRSELVI-----------TWESIPEELQNGEG----FGYIIMFRPV--GSTTWS 749
Query: 524 ---ISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKE 580
+S + +++ + P S +EV++ YN GEG + VT I+ S E
Sbjct: 750 KEKVSSVESSRFVYRNESIIPLSPFEVKVGVYNNEGEGSLSTVT----------IVYSGE 799
Query: 581 QQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFR 640
+ Q G S QS S ASE V I + +
Sbjct: 800 DEPQLAPRGTSLQSFS--------------------ASEMEVSWNAIAWNRNTGRVLGYE 839
Query: 641 VEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYV 700
V Y + ++ + + + ITGL+ T Y VRA N G + PS P V
Sbjct: 840 VLY-WTDDSKESMIGKIRVSGNVTTKNITGLKANTIYFASVRAYNTAG----TGPSSPPV 894
Query: 701 VSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDND 760
+ + P + P + + + L W ++ N + + G+ I YR +
Sbjct: 895 ----NVTTKKSPPSQPPANIAWKLTNSKLCLNWEHVKTMENESEVLGYKILYR-----QN 945
Query: 761 SDYKKDMVEGDKYWHSISHLQP-ETSYDIKMQCFNEGGESEFS 802
K ++E + S L P E Y I+++ ++GG+ S
Sbjct: 946 RQSKTHILETNN--TSAELLVPFEEDYLIEIRTVSDGGDGSSS 986
Score = 73.6 bits (179), Expect = 1e-12
Identities = 52/204 (25%), Positives = 84/204 (41%), Gaps = 8/204 (3%)
Query: 605 PPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILAT--SAIPPS 662
PP P+ + S T+ ++W + PIQ F ++ + VG +AT +
Sbjct: 597 PPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQAVATVPEILNGK 656
Query: 663 RLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTD 722
+ + GL Y+FRV A N +G EPS PS PV P
Sbjct: 657 TYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKA------SVPVVAPVNIHGG 710
Query: 723 AVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQP 782
+ + +++ W IP N G+ I +RP S S K VE ++ + + P
Sbjct: 711 GGSRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNESIIP 770
Query: 783 ETSYDIKMQCFNEGGESEFSNVMI 806
+ +++K+ +N GE S V I
Sbjct: 771 LSPFEVKVGVYNNEGEGSLSTVTI 794
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 122 bits (305), Expect = 2e-27
Identities = 100/361 (27%), Positives = 159/361 (44%), Gaps = 27/361 (7%)
Query: 64 MNVTWRLNGKELNGSDDALGVLITH-GTLVITALNNHTVGRYQCVARMPAGAVASVPATV 122
+ V W +G L ++ + + TL I + G+Y C A P G +S
Sbjct: 6204 IQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLT 6263
Query: 123 TLANLQDFKLDVQHV-IEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMP 181
+ D++ V I+V G +A CH+ + P ++ +S + + GNY I
Sbjct: 6264 AREPKKSPFFDIKPVSIDVIAGESADFECHVTGAQPM-RITWSKDNKEIRPG-GNYTITC 6321
Query: 182 SGN---LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQ 238
GN L+I+ + D G Y C A N V D + S E + + EA
Sbjct: 6322 VGNTPHLRILKVGKGDSGQYTCQATNDV--------GKDMCSAQLSVKEPPKFVKKLEAS 6373
Query: 239 TIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN----LLIDTTSEEDS 294
+ +G+S+ LEC SG P +V+W ++ S + K N L I+ S EDS
Sbjct: 6374 KV-AKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDS 6432
Query: 295 GTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSV 354
G Y C A NGVG + L V PP T + S + G L CE+ G PP V
Sbjct: 6433 GDYICEAHNGVGDASCSTAL---TVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEV 6489
Query: 355 LWLRNAVPLISSQRLRLSRR----ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSR 410
+W+++ + +S++ +++ + +L +L++ D G Y C A NEVGS ++
Sbjct: 6490 VWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKE 6549
Query: 411 P 411
P
Sbjct: 6550 P 6550
Score = 108 bits (270), Expect = 3e-23
Identities = 114/414 (27%), Positives = 168/414 (40%), Gaps = 46/414 (11%)
Query: 53 VILGCVVEPPR-MNVTWRLNGKELN-GSDDALGVLITHGTLVITALNNHTVGRYQCVARM 110
V L C V+ R + VTW +G++L G D + TL I G Y C A
Sbjct: 3661 VHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASN 3720
Query: 111 PAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWL 170
AG+ +S ATVT+ F V + G +A + C L S P QV + + L
Sbjct: 3721 EAGS-SSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGS-PVIQVTWFKNNKEL 3778
Query: 171 EASRG--NYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEA 228
S Y + L I + ED G Y C A N V SD E
Sbjct: 3779 SESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDV--------GSDSCSTEIVIKEP 3830
Query: 229 ARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLL--- 285
I E I+ +G + +L+C SG P ++W KD + K R L
Sbjct: 3831 PSFIKTLEPADIV--RGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCL 3888
Query: 286 -IDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTC 344
I + + D G Y C+ N VG+ G + + EPP ++ L+ GQ+ L
Sbjct: 3889 EIFSFNSADVGEYECVVANEVGKCGC---MATHLLKEPPTFVKKVDDLIALGGQTVTLQA 3945
Query: 345 EVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDE----GVYQCMAENEVGSA 400
VRG+ P SV W++ + ++++S + + P+ + G Y C+AENE GS
Sbjct: 3946 AVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQ 4005
Query: 401 HAVVQLRTSRPSITPRLWQDAEL--------------ATGTPPVSPS--KLGNP 438
+V +L P+ ++ + AEL GTP + P K G P
Sbjct: 4006 TSVGELIVKEPA---KIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRP 4056
Score = 107 bits (268), Expect = 5e-23
Identities = 103/380 (27%), Positives = 157/380 (41%), Gaps = 39/380 (10%)
Query: 50 GGTVILGCVVEPPR-MNVTWRLNGKELNGSDD-ALGVLITHGTLVITALNNHTVGRYQCV 107
G + L C+V +++ W + +E++ S+ L I+ L G Y C
Sbjct: 4689 GSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCS 4748
Query: 108 ARMPAG--------AVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKA 159
A AG V P V QD + + ++ G TA + + +
Sbjct: 4749 ATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDN--- 4805
Query: 160 QVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRL 219
K+ A+R + S +L++ A D G Y C N +V T+ S L
Sbjct: 4806 ------KELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSN----DVGTATSKATL 4855
Query: 220 RVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNK--T 277
V+ E + I P + +++ GQS EC +G P RV+W DG+ +T K
Sbjct: 4856 FVK----EPPQFIKKP-SPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGI 4910
Query: 278 RFL--LSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIP 335
F+ L+ I E+SGTY C A N G ++ L +V EPP EL + +
Sbjct: 4911 SFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIEL---KVKEPPTFIRELKPVEVV 4967
Query: 336 WGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRA----LRVLSMGPEDEGVYQC 391
+L CEV G PP V WL+N + SS++ L+ R L + P D G YQC
Sbjct: 4968 KYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQC 5027
Query: 392 MAENEVGSAHAVVQLRTSRP 411
+ NE GS ++ P
Sbjct: 5028 IVSNEGGSCSCSTRVALKEP 5047
Score = 107 bits (267), Expect = 6e-23
Identities = 111/391 (28%), Positives = 153/391 (39%), Gaps = 51/391 (13%)
Query: 50 GGTVILGC-VVEPPRMNVTWRLNGKELNGSDDALGVLITH-GTLVITALNNHTVGRYQCV 107
G +V L C V P + V+W +L + + + TLV +N + G Y C
Sbjct: 6093 GDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCK 6152
Query: 108 ARMPAGAVASVPATVTLANLQDFKLDVQHV-----IEVDEGNTAVIACHLPESHPKAQVR 162
A G +S T+ +Q+ +L IE G + C L S P
Sbjct: 6153 AENSIGTASSK----TVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCW 6208
Query: 163 YSVKQEWLEASRGNYLIMPSGNLQ-----------IVNASQEDEGMYKCAAYNPVTQEVK 211
Y R L+ NLQ I+ G Y C+A NP+
Sbjct: 6209 Y----------RDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLG---- 6254
Query: 212 TSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSV 271
T+ SS RL R I P +I V G+S EC +G P R+TW+KD +
Sbjct: 6255 TASSSARLTAREPKKSPFFDIKPV---SIDVIAGESADFECHVTGAQPMRITWSKDNKEI 6311
Query: 272 T-GYNKTRFLLSN---LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTM 327
G N T + N L I + DSG Y C A N VG+ + L V EPP+
Sbjct: 6312 RPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQL---SVKEPPKFVK 6368
Query: 328 EL-SQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSR----RALRVLSMG 382
+L + V G+S +L C++ G+P V W RN L S + +S L +
Sbjct: 6369 KLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEAS 6428
Query: 383 PEDEGVYQCMAENEVGSAHAVVQLRTSRPSI 413
ED G Y C A N VG A L P +
Sbjct: 6429 AEDSGDYICEAHNGVGDASCSTALTVKAPPV 6459
Score = 102 bits (254), Expect = 2e-21
Identities = 107/414 (25%), Positives = 170/414 (41%), Gaps = 30/414 (7%)
Query: 19 ACLLLATAG---CFADLNEV-PQVTVQPASTVQKP-GGTVILGCVVE-PPRMNVTWRLNG 72
+CL+ AG C A ++ + P ++P V+ G L C V+ P + ++W
Sbjct: 6998 SCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEH 7057
Query: 73 KELNGSDD-ALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLAN-LQDF 130
+L + + +LVI +++ VG Y C A GAVAS V A L F
Sbjct: 7058 TKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPPF 7117
Query: 131 KLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWL--EASRGNYLIMPSGNLQIV 188
+ G C + S P QV + L +A+ + LQI+
Sbjct: 7118 FARKLKDVHETLGFPVAFECRINGSEP-LQVSWYKDGVLLKDDANLQTSFVHNVATLQIL 7176
Query: 189 NASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSL 248
Q G Y C+A NP+ T+ SS +L + + P + G+S
Sbjct: 7177 QTDQSHIGQYNCSASNPLG----TASSSAKLILSEHEVPPFFDLKPVSVDLAL---GESG 7229
Query: 249 ILECVASGIPPPRVTWAKDGSSVT-GYNKTRFLLSN---LLIDTTSEEDSGTYRCMADNG 304
+C +G P ++TWAKD + G N L+ N L + + D+G Y C A N
Sbjct: 7230 TFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNI 7289
Query: 305 VGQPGAAVILYNVQVFEPPEVTMELS-QLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPL 363
G+ + L V EPP +L ++ + + C++ G+P VLW ++ +
Sbjct: 7290 AGKDSCSAQL---GVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEI 7346
Query: 364 ISSQRLRLSR----RALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSI 413
S + R+S L + ++ ED G Y C A N GSA + L+ P I
Sbjct: 7347 QESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPI 7400
Score = 101 bits (252), Expect = 3e-21
Identities = 97/402 (24%), Positives = 162/402 (40%), Gaps = 58/402 (14%)
Query: 64 MNVTWRLNGKELNGSDDALGVLITHG--TLVITALNNHTVGRYQCVARMPAG-----AVA 116
++V W + E+ D + + + TL + + G+Y C + AG A
Sbjct: 7521 ISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATL 7580
Query: 117 SV--PATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASR 174
SV PAT+ ++ I+V G+T + C + + P+ ++ + L S
Sbjct: 7581 SVLEPATI---------VEKPESIKVTTGDTCTLECTVAGT-PELSTKWFKDGKEL-TSD 7629
Query: 175 GNYLIM---PSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARI 231
Y I L+I+N + D G+Y NPV ++ T+ S + R
Sbjct: 7630 NKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTA----------SLQVSDRT 7679
Query: 232 IYPPEAQTIIVTKG---QSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN----L 284
+ P + + T G S+++EC G PP V+W +G+ ++ K + L++ L
Sbjct: 7680 VPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCAL 7739
Query: 285 LIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTC 344
++ E DSG Y C+A N G + L V EPP + + + G + T
Sbjct: 7740 TVNMLEESDSGDYTCIATNMAGSDECSAPL---TVREPPSFVQKPDPMDVLTGTNVTFTS 7796
Query: 345 EVRGNPPPSVLWLRNAVPLISSQRLRLSRR----ALRVLSMGPEDEGVYQCMAENEVGSA 400
V+G PP SV W + + L+ R +S L + + G Y C+ NE G A
Sbjct: 7797 IVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKA 7856
Query: 401 HAVVQLRTSRPSITPRLWQDAELA-----------TGTPPVS 431
L P+ + D + TGTPP+S
Sbjct: 7857 SCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPIS 7898
Score = 99.4 bits (246), Expect = 2e-20
Identities = 113/448 (25%), Positives = 167/448 (37%), Gaps = 43/448 (9%)
Query: 24 ATAGCFADLNEVPQVTVQPASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDDAL 82
A++ + E P +P G V L C ++ P +V+W + +EL S
Sbjct: 7387 ASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELR-SGKKY 7445
Query: 83 GVLITHGTLVITALNNHT--VGRYQCVARMPAGAVASVPATVTLANLQDFKL--DVQHVI 138
++ + I LN +G YQC A G+ V + A + K D+ V+
Sbjct: 7446 KIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVV 7505
Query: 139 EVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGN---LQIVNASQEDE 195
G + + + P + V + K E + S N I S N LQ +
Sbjct: 7506 ----GKEVQLQTTIEGAEPISVVWFKDKGEIVRES-DNIWISYSENIATLQFSRVEPANA 7560
Query: 196 GMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVAS 255
G Y C ++K S E A I+ PE+ I VT G + LEC +
Sbjct: 7561 GKYTC--------QIKNDAGMQECFATLSVLEPATIVEKPES--IKVTTGDTCTLECTVA 7610
Query: 256 GIPPPRVTWAKDGSSVTGYNKTRFL----LSNLLIDTTSEEDSGTYRCMADNGVGQPGAA 311
G P W KDG +T NK + +S L I + DSG Y N VG+
Sbjct: 7611 GTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCT 7670
Query: 312 VILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL 371
L PP T +L + G S + C+V G+PP SV W + S ++ +
Sbjct: 7671 ASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQT 7730
Query: 372 SRR----ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPS-----------ITPR 416
+ AL V + D G Y C+A N GS L P +T
Sbjct: 7731 TLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGT 7790
Query: 417 LWQDAELATGTPPVSPSKLGNPEQMLRG 444
+ GTPP S S +++ G
Sbjct: 7791 NVTFTSIVKGTPPFSVSWFKGSSELVPG 7818
Score = 98.6 bits (244), Expect = 3e-20
Identities = 90/388 (23%), Positives = 149/388 (38%), Gaps = 42/388 (10%)
Query: 36 PQVTVQPASTVQKPGGTVILGCVVEPPR-MNVTWRLNGKELNGSDDA-LGVLITHGTLVI 93
P + Q + G V+ C + ++V+W +GK L S + L TL I
Sbjct: 8057 PSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNI 8116
Query: 94 TALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHV-IEVDEGNTAVIACHL 152
+ G+Y C A P G+ +S + D++ ++ G +A CH+
Sbjct: 8117 FKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHV 8176
Query: 153 PESHPKAQVRYSVKQEWLEASR-----GNYLIM---PSGNLQIVNASQEDEGMYKCAAYN 204
+ P +K W + SR G Y I S +L ++ + D G Y C A N
Sbjct: 8177 TGTQP-------IKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVN 8229
Query: 205 PVTQEVKTSGSSDRLRVRRSTAEAARIIYPPE-----AQTIIVTKGQSLILECVASGIPP 259
V ++ T+ + + R + PP ++T+ T+G S LE +G P
Sbjct: 8230 EVGKDSCTAQLNIKER-----------LIPPSFTKRLSETVEETEGNSFKLEGRVAGSQP 8278
Query: 260 PRVTWAKDGSSVTGYNKTRFLLSN----LLIDTTSEEDSGTYRCMADNGVGQPGAAVILY 315
V W K+ + + N L + D+G Y C N G +
Sbjct: 8279 ITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIV 8338
Query: 316 NVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLS--- 372
+ +PP L+ + + G+ +L+C V+G+ P + WL+ + S R S
Sbjct: 8339 IKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFAS 8398
Query: 373 -RRALRVLSMGPEDEGVYQCMAENEVGS 399
L + + D G Y C A N GS
Sbjct: 8399 GTAVLELRDVAKADSGDYVCKASNVAGS 8426
Score = 97.1 bits (240), Expect = 8e-20
Identities = 100/422 (23%), Positives = 170/422 (40%), Gaps = 32/422 (7%)
Query: 25 TAGCFADLNEVPQVTVQPASTVQKPGGTVILGCVVEPPR-MNVTW-RLNGKELNGSDDA- 81
T C E P+ + + T G V L +VE + ++V W + G+ + S++
Sbjct: 6540 TCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTR 6599
Query: 82 LGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVD 141
+ + TL + + G+Y C + AG + A +T+ ++ + V
Sbjct: 6600 ISFIDNIATLQLGSPEASNSGKYICQIKNDAG-MRECSAVLTVLEPARI-IEKPEPMTVT 6657
Query: 142 EGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYL--IMPSGNLQIVNASQEDEGMYK 199
GN + C + + P+ ++ L A +++ I +L+I A D+G+Y
Sbjct: 6658 TGNPFALECVVTGT-PELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYS 6716
Query: 200 CAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPP---EAQTIIVTKGQSLILECVASG 256
EVK S V S + RI+ P + + + G S++LEC SG
Sbjct: 6717 F--------EVKNSVGKSNCTV--SVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSG 6766
Query: 257 IPPPRVTWAKDGSSVTGYNKTRFLLSN----LLIDTTSEEDSGTYRCMADNGVGQPGAAV 312
P V W +DG+ + K + S L + D+G Y C+A N G +
Sbjct: 6767 SAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSA 6826
Query: 313 ILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLS 372
+L V EPP + + G S T +RG PP V W + + L+ + +S
Sbjct: 6827 VL---TVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNIS 6883
Query: 373 RR----ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTP 428
L + + P + G Y C+ N+ GSA L P+ + D + TG+P
Sbjct: 6884 LEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVETGSP 6943
Query: 429 PV 430
V
Sbjct: 6944 IV 6945
Score = 95.5 bits (236), Expect = 2e-19
Identities = 89/361 (24%), Positives = 139/361 (38%), Gaps = 23/361 (6%)
Query: 62 PRMNVTWRLNGKELNGSDD-ALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPA 120
P V W + ++L S + H ++ I ++ +G Y C A+ G+ V
Sbjct: 5544 PPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCV-C 5602
Query: 121 TVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIM 180
TV L F + + + V G A + + + P K+E + S +
Sbjct: 5603 TVKLKEPPRF-VSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITF 5661
Query: 181 PSG--NLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQ 238
LQ A + G Y C ++K G E A I+ +A
Sbjct: 5662 VENVATLQFAKAEPANAGKYIC--------QIKNDGGMRENMATLMVLEPAVIV--EKAG 5711
Query: 239 TIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFL----LSNLLIDTTSEEDS 294
+ VT G++ LEC +G P V W KDG +T K +F +S+L I + +D+
Sbjct: 5712 PMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDA 5771
Query: 295 GTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSV 354
GTY N VG+ ++ PP T L G S L C+V G+ P SV
Sbjct: 5772 GTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISV 5831
Query: 355 LWLRNAVPLISSQRLRLSRR----ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSR 410
W ++S + + + L++ S+ D G Y C+A N GS L
Sbjct: 5832 AWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQE 5891
Query: 411 P 411
P
Sbjct: 5892 P 5892
Score = 94.4 bits (233), Expect = 6e-19
Identities = 99/381 (25%), Positives = 153/381 (40%), Gaps = 39/381 (10%)
Query: 36 PQVTVQPASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDD-ALGVLITHGTLVI 93
P +P S G C V P + W+ +G L+ S + + L +
Sbjct: 3551 PTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILEL 3610
Query: 94 TALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVI-EVDEGNTAV----- 147
+ L G Y C A GA + + +D H I E++ +A+
Sbjct: 3611 SNLTIQDRGVYSCKASNKFGA--------DICQAELIIIDKPHFIKELEPVQSAINKKVH 3662
Query: 148 IACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPS--GNLQIVNASQEDEGMYKCAAYNP 205
+ C + E K V +S + L + + L+I A +D G Y C A N
Sbjct: 3663 LECQVDEDR-KVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASN- 3720
Query: 206 VTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWA 265
E +S S + VR + ++ + ++ G+S L C G P +VTW
Sbjct: 3721 ---EAGSSSCSATVTVREPPSFVKKV-----DPSYLMLPGESARLHCKLKGSPVIQVTWF 3772
Query: 266 KDGSSVTGYNKTR--FLLSNLLIDTTSE--EDSGTYRCMADNGVGQPGAAVILYNVQVFE 321
K+ ++ N R F+ S ++D T EDSG+Y C A N VG + + + E
Sbjct: 3773 KNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCST---EIVIKE 3829
Query: 322 PPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL----SRRALR 377
PP L I G +A L CEV G P + W ++ + SS++ RL S L
Sbjct: 3830 PPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLE 3889
Query: 378 VLSMGPEDEGVYQCMAENEVG 398
+ S D G Y+C+ NEVG
Sbjct: 3890 IFSFNSADVGEYECVVANEVG 3910
Score = 94.0 bits (232), Expect = 7e-19
Identities = 98/394 (24%), Positives = 146/394 (37%), Gaps = 36/394 (9%)
Query: 36 PQVTVQPASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDDALGVLITH--GTLV 92
P T +P+ G VIL C + P V W + K++ S + H +L
Sbjct: 6458 PVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKK-FKITSKHFDTSLH 6516
Query: 93 ITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAV----- 147
I L VG Y C A G+ T + FK + V ++ + +T +
Sbjct: 6517 ILNLEASDVGEYHCKATNEVGSD-------TCSCSVKFKEPPRFVKKLSDTSTLIGDAVE 6569
Query: 148 IACHLPESHPKAQVRYSVKQEWLEASRGNYL--IMPSGNLQIVNASQEDEGMYKCAAYNP 205
+ + P + V + E + S + I LQ+ + + G Y C
Sbjct: 6570 LRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYIC----- 6624
Query: 206 VTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWA 265
++K + E ARII PE T VT G LECV +G P W
Sbjct: 6625 ---QIKNDAGMRECSAVLTVLEPARIIEKPEPMT--VTTGNPFALECVVTGTPELSAKWF 6679
Query: 266 KDGSSVTGYNKTRFLLSN----LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFE 321
KDG ++ +K N L I D G Y N VG+ V ++
Sbjct: 6680 KDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIV 6739
Query: 322 PPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRR----ALR 377
PP +L + G S L C V G+ P SV W ++ ++S + + S L
Sbjct: 6740 PPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLN 6799
Query: 378 VLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRP 411
+ + P D G+Y C+A N GS L P
Sbjct: 6800 LSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEP 6833
Score = 93.6 bits (231), Expect = 9e-19
Identities = 101/401 (25%), Positives = 159/401 (39%), Gaps = 33/401 (8%)
Query: 45 TVQKPGGTVILGCVVEPPRMNVTWRLNGKELNGSDDA-LGVLITHGTLVITALNNHTVGR 103
+++K ++ G P ++VTW+ NG + S + L I + G+
Sbjct: 7878 SIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQ 7937
Query: 104 YQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHL---PE---SHP 157
Y C +G S A + + F ++ V +V G++A + C L PE S
Sbjct: 7938 YNCYIENASGK-DSCSAQILILEPPYFVKQLEPV-KVSVGDSASLQCQLAGTPEIGVSWY 7995
Query: 158 KAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSD 217
K + + R N + + I D G Y C A N V + +S
Sbjct: 7996 KGDTKLRPTTTYKMHFRNNVATLVFNQVDI-----NDSGEYICKAENSVGEV----SAST 8046
Query: 218 RLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYN-- 275
L V+ + + + + + T G ++ +C SG P V+W KDG +
Sbjct: 8047 FLTVQEQKLPPS---FSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNV 8103
Query: 276 KTRFL--LSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLV 333
+T FL + L I T +G Y C A N +G ++ L + PP + L+ +
Sbjct: 8104 QTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVD 8163
Query: 334 IPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLS----RRALRVLSMGPEDEGVY 389
G+SA C V G P V W +++ + S + ++S L VL + D G Y
Sbjct: 8164 AVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQY 8223
Query: 390 QCMAENEVGSAHAVVQL----RTSRPSITPRLWQDAELATG 426
C A NEVG QL R PS T RL + E G
Sbjct: 8224 TCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEG 8264
Score = 92.8 bits (229), Expect = 2e-18
Identities = 97/400 (24%), Positives = 171/400 (42%), Gaps = 38/400 (9%)
Query: 32 LNEVPQVTVQPASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKEL-NGSDDALGVLITHG 89
+ E P V+P P TV +++ P + W + EL +G +G+ +
Sbjct: 5326 VKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTS 5385
Query: 90 TLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDF--KLDVQHVIEVDEGNTAV 147
L + +++ G+Y C G+ S + + F KL+ +++ G+++
Sbjct: 5386 FLNLYSVDASKTGQYTCHVTNDVGS-DSCTTMLLVTEPPKFVKKLEASKIVKA--GDSSR 5442
Query: 148 IACHLPESHPKAQVRYSVKQEWLEASRGNYL--IMPSGNLQIVNASQEDEGMYKCAAYNP 205
+ C + S P+ +V + + L AS + I +Q+ N S ED G + C A NP
Sbjct: 5443 LECKIAGS-PEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNP 5501
Query: 206 VTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWA 265
++ S ++ V+ ++ +PP +T+ K + LEC SG PP V W
Sbjct: 5502 AG----STSCSTKVIVKEPPVFSS---FPPIVETL---KNAEVSLECELSGTPPFEVVWY 5551
Query: 266 KDGSSVTGYNKTRFLLSN-------LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQ 318
KD + K + N L +DT+ D G Y C A N V G+ + V+
Sbjct: 5552 KDKRQLRSSKKYKIASKNFHTSIHILNVDTS---DIGEYHCKAQNEV---GSDTCVCTVK 5605
Query: 319 VFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLI-SSQRLRL----SR 373
+ EPP +L+ L + G+ A+L + G P V WL+ +I S+ +R+ +
Sbjct: 5606 LKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENV 5665
Query: 374 RALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSI 413
L+ P + G Y C +N+ G + L P++
Sbjct: 5666 ATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAV 5705
Score = 92.0 bits (227), Expect = 3e-18
Identities = 91/401 (22%), Positives = 150/401 (37%), Gaps = 35/401 (8%)
Query: 32 LNEVPQVTVQPASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDDA-LGVLITHG 89
+ E P +P PG V V+ P V W +EL D + T
Sbjct: 5889 VQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVA 5948
Query: 90 TLVITALNNHTVGRYQCVARMPAGAVASV-------PATVTLANLQDFKLDVQHVIEVDE 142
L + ++ G Y CV AG + PA L L D ++ I ++
Sbjct: 5949 ELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAF-LKRLSDHSVEPGKSIILES 6007
Query: 143 GNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAA 202
T + + + S K + + + L+I+N+++ D G Y C
Sbjct: 6008 TYTGTLPISVTWKKDGFNITTSEKCNIVTTEK-------TCILEILNSTKRDAGQYSC-- 6058
Query: 203 YNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRV 262
E++ D ST E + E + + G S+ L+C +G P V
Sbjct: 6059 ------EIENEAGRDVCGALVSTLEPPYFV--TELEPLEAAVGDSVSLQCQVAGTPEITV 6110
Query: 263 TWAKDGSSVTGYNKTRFLLSN----LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQ 318
+W K + + + R +N L+ + + DSG Y C A+N +G + + +
Sbjct: 6111 SWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQE 6170
Query: 319 VFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLS----RR 374
PP +L + G LTC + G+ P V W R+ V L + L+ S
Sbjct: 6171 RQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVA 6230
Query: 375 ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITP 415
L++L G Y C A N +G+A + +L P +P
Sbjct: 6231 TLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSP 6271
Score = 90.5 bits (223), Expect = 8e-18
Identities = 100/393 (25%), Positives = 157/393 (39%), Gaps = 35/393 (8%)
Query: 43 ASTVQKPGGTVILGC-VVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLV-ITALNNHT 100
AS + K G + L C + P + V W N EL SD I ++ + L+
Sbjct: 5431 ASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTED 5490
Query: 101 VGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQ 160
G + C A+ PAG+ + +T + ++E + + C L + P
Sbjct: 5491 SGDFICEAQNPAGSTSC--STKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEV 5548
Query: 161 VRYSVKQEWLEASRGNYLIMPSG---NLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSD 217
V Y K++ L +S+ Y I ++ I+N D G Y C A N V SD
Sbjct: 5549 VWYKDKRQ-LRSSK-KYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEV--------GSD 5598
Query: 218 RLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKT 277
E R + + T++ G+ L+ G P V W K+ V ++
Sbjct: 5599 TCVCTVKLKEPPRFVSKLNSLTVVA--GEPAELQASIEGAQPIFVQWLKEKEEVIRESEN 5656
Query: 278 RFL-----LSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQL 332
+ ++ L ++G Y C N G L V EP + + +
Sbjct: 5657 IRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATL---MVLEPAVIVEKAGPM 5713
Query: 333 VIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSR----RALRVLSMGPEDEGV 388
+ G++ L C+V G P SV W ++ L SSQ+ + S +LR+LS+ +D G
Sbjct: 5714 TVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGT 5773
Query: 389 YQCMAENEVG--SAHAVVQL--RTSRPSITPRL 417
Y +N VG S AVV + R PS T RL
Sbjct: 5774 YTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRL 5806
Score = 89.7 bits (221), Expect = 1e-17
Identities = 112/484 (23%), Positives = 178/484 (36%), Gaps = 89/484 (18%)
Query: 317 VQVFEPPEVTME---LSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLS- 372
V E PE+ ++ L+ L + G +L V G P P + W + + L +R+ +
Sbjct: 13682 VDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIEN 13741
Query: 373 ---RRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAE------L 423
+ + ++ D G Y A N G A AVV++ P + + L
Sbjct: 13742 VPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCL 13801
Query: 424 ATGTPPVSP--SKLGN--------------------PEQMLRGQPALPRPPTSVGPASPQ 461
T PP SK+ N + + +P A+
Sbjct: 13802 LTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAEN 13861
Query: 462 C--PGEKGQGAPAEA--------PIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVK 511
GE Q +P A P P D+ L W + G +PI Y V+
Sbjct: 13862 MYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGG-SPITGYWVE 13920
Query: 512 HRKVTNSSDDWT-ISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRR 570
++ +D W + +P + L Y + A N AG G+ + T
Sbjct: 13921 --RLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKST------ 13972
Query: 571 PKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWI-PR 629
+ I DP + PP P +PT+ +TSV + W P
Sbjct: 13973 ----------EPILIKDP--------------IDPPWPPGKPTVKDVGKTSVRLNWTKPE 14008
Query: 630 GNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGE 689
+GG I+S+ +E K +W+ +P ++ + GL +G Y FRVRA+N GE
Sbjct: 14009 HDGGAKIESYVIEMLKTG-TDEWVRVAEGVPTTQHL--LPGLMEGQEYSFRVRAVNKAGE 14065
Query: 690 SEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFY 749
SEPS PS P + R P + P + + T LKW +P + +PI +
Sbjct: 14066 SEPSEPSDPVLC-----REKLYPPSPPRWLEVINITKNTADLKWT-VPEKDGGSPITNYI 14119
Query: 750 IYYR 753
+ R
Sbjct: 14120 VEKR 14123
Score = 89.4 bits (220), Expect = 2e-17
Identities = 94/390 (24%), Positives = 154/390 (39%), Gaps = 31/390 (7%)
Query: 25 TAGCFADLNEVPQVT----VQPASTVQKPGGTVILGC-VVEPPRMNVTWRLNGKELNGSD 79
TA C +L T ++P V+ V L C V P VTW N +E+ S
Sbjct: 4942 TASCSIELKVKEPPTFIRELKPVEVVKY--SDVELECEVTGTPPFEVTWLKNNREIRSSK 4999
Query: 80 D-ALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVI 138
L ++ L IT + G YQC+ G+ S V L F +++
Sbjct: 5000 KYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGS-CSCSTRVALKEPPSFIKKIENTT 5058
Query: 139 EVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYL--IMPSGNLQIVNASQEDEG 196
V + + + P + + + L+ Y+ + LQI + G
Sbjct: 5059 TVLKSSATFQST--VAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSG 5116
Query: 197 MYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASG 256
Y C A K +R E A+I+ +A+++ VT+ + LECV +G
Sbjct: 5117 RYTCQA--------KNESGVERCYAFLLVQEPAQIV--EKAKSVDVTEKDPMTLECVVAG 5166
Query: 257 IPPPRVTWAKDGSSV--TGYNKTRFL--LSNLLIDTTSEEDSGTYRCMADNGVGQPGAAV 312
P +V W KDG + + Y F +++ I + ++DSG Y +N G
Sbjct: 5167 TPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDA 5226
Query: 313 ILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL- 371
L + PP T +L+++ G S + C+V G+ P S W ++ + +S + RL
Sbjct: 5227 YLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLV 5286
Query: 372 ---SRRALRVLSMGPEDEGVYQCMAENEVG 398
+L V ++ ED Y C N G
Sbjct: 5287 CHERSVSLEVNNLELEDTANYTCKVSNVAG 5316
Score = 89.4 bits (220), Expect = 2e-17
Identities = 87/345 (25%), Positives = 135/345 (39%), Gaps = 34/345 (9%)
Query: 90 TLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKL---------DVQHVIEV 140
TLV ++ + G Y C A G V++ T +Q+ KL DVQ +
Sbjct: 8017 TLVFNQVDINDSGEYICKAENSVGEVSAS----TFLTVQEQKLPPSFSRQLRDVQETV-- 8070
Query: 141 DEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPS-GNLQIVNASQEDEGMYK 199
G V C + S P + Y + ++ + + L I + G Y
Sbjct: 8071 --GLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYS 8128
Query: 200 CAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPP 259
C A NP+ ++ SS RL + I ++ G+S EC +G P
Sbjct: 8129 CTATNPIG----SASSSARLILTEGKNPPFFDIRLAPVDAVV---GESADFECHVTGTQP 8181
Query: 260 PRVTWAKDGSSVTGYNKTRFLL----SNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILY 315
+V+WAKD + K + ++L + + DSG Y C A N VG+ L
Sbjct: 8182 IKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLN 8241
Query: 316 NVQVFEPPEVTMELSQLVIPW-GQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRR 374
+ PP T LS+ V G S KL V G+ P +V W +N + + + ++ +
Sbjct: 8242 IKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFK 8301
Query: 375 ----ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITP 415
L+V G D G+Y C N+ GSA + P P
Sbjct: 8302 NNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPP 8346
Score = 87.0 bits (214), Expect = 9e-17
Identities = 99/440 (22%), Positives = 171/440 (38%), Gaps = 110/440 (25%)
Query: 322 PPEVTMEL---SQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRR---- 374
PP + + + S L + G + L V G P P+V W ++ L ++ ++++ +
Sbjct: 19292 PPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLC 19351
Query: 375 ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITP------RLWQDAELATGTP 428
L + S+ +D G Y AEN GS A ++L+ P +++ D + + P
Sbjct: 19352 TLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEP 19411
Query: 429 PVS----------------------------PSKLGNPEQMLRGQ--------------- 445
P+ P + E+++ G
Sbjct: 19412 PLEDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVG 19471
Query: 446 -PALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAP 504
P P + P P PG + P+I + + T S W+P + G +P
Sbjct: 19472 DPVFTEPAIAKNPYDP--PGR------CDPPVISNITKDHMTVS----WKPPADDGG-SP 19518
Query: 505 ILYYVVKHRKVTNSSDDWT-ISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMV 563
I Y+++ R+ + +WT ++ P + L T L G+ YE + A N AG G+
Sbjct: 19519 ITGYLLEKRET--QAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGK---- 19572
Query: 564 TFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGR--LSPPEAPDRPTISTASETS 621
P +S+ + R PP P P + + +S
Sbjct: 19573 ----------------------------PSDASKAAYARDPQYPPGPPAFPKVYDTTRSS 19604
Query: 622 VYVTW-IPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFR 680
V ++W P +GG PI + VE K+ +W+ + E+TGL + T Y+FR
Sbjct: 19605 VSLSWGKPAYDGGSPIIGYLVEVKRADS-DNWVRCNLPQNLQKTRFEVTGLMEDTQYQFR 19663
Query: 681 VRALNMLGESEPS-APSRPY 699
V A+N +G S+PS P + Y
Sbjct: 19664 VYAVNKIGYSDPSDVPDKHY 19683
Score = 85.5 bits (210), Expect = 3e-16
Identities = 114/510 (22%), Positives = 190/510 (37%), Gaps = 134/510 (26%)
Query: 268 GSSVTGY----------NKTRF-LLSNLLIDTTSEEDSGTYR--CMADN--GVGQPGAAV 312
GS +TGY + +F ++NL T + TYR A+N G+G P +
Sbjct: 17438 GSPITGYLVEYQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTI 17497
Query: 313 ILYNVQVFEPPEVTME---LSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRL 369
+ + PP V ++ + LV+ G + + +RG P P+ W + + + +
Sbjct: 17498 PIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHY 17557
Query: 370 RLSR----RALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELAT 425
+ L + + D G YQ N GS V L
Sbjct: 17558 TVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLD--------------- 17602
Query: 426 GTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSK 485
+P PPT GP + I+ +P
Sbjct: 17603 ----------------------VPGPPT--GPIN----------------ILDVTP---- 17618
Query: 486 TDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLY 545
+ + W+P + G +P++ Y+V+ K D W + +++ +L + L G Y
Sbjct: 17619 -EHMTISWQPPKDDGG-SPVINYIVE--KQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEY 17674
Query: 546 EVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSP 605
+ A N G G T P + K SP
Sbjct: 17675 VFRVRAENKIGVGPPLDST--------PTVAKHK-----------------------FSP 17703
Query: 606 PEAPDRPTISTASETSVYVTW-IPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRL 664
P P +P ++ +E + V+W +P+ +GG PI + +E +++ G W+ P + L
Sbjct: 17704 PSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERREV--TGKWVRVNKT-PIADL 17760
Query: 665 SVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPV--AGPYIT--F 720
+TGL +G +Y+FRV A N+ G S+PS S P RP+ GP I
Sbjct: 17761 KFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKAC--------RPIKPPGPPINPKL 17812
Query: 721 TDAVNETTIMLKWMYIPASNNNTPIHGFYI 750
D ET ++ W P S+ +PI G+ +
Sbjct: 17813 KDKSRETADLV-WTK-PLSDGGSPILGYVV 17840
Score = 84.7 bits (208), Expect = 4e-16
Identities = 118/570 (20%), Positives = 213/570 (37%), Gaps = 98/570 (17%)
Query: 297 YRCMADN--GVGQPGAAVILYN-VQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPS 353
+R A+N G+ +P A V + P+V + S L + G L + G+P P+
Sbjct: 14652 FRVRAENAAGISEPSRATPPTKAVDPIDAPKVILRTS-LEVKRGDEIALDASISGSPYPT 14710
Query: 354 VLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSI 413
+ W+++ ++ + + +RA ++ + EV V T R SI
Sbjct: 14711 ITWIKDENVIVPEE---IKKRAAPLVRR-----------RKGEVQEEEPFVLPLTQRLSI 14756
Query: 414 TPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAE 473
+++L + P G + + + P +V P
Sbjct: 14757 DNSKKGESQLRV-RDSLRPDH-GLYMIKVENDHGIAKAPCTVSVLDTPGP---------- 14804
Query: 474 APIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHR 533
PI KT S W P + G + I+ Y ++ + T +W + +
Sbjct: 14805 -PINFVFEDIRKT-SVLCKWEPPLDDGG-SEIINYTLEKKDKTKPDSEWIVVTSTLRHCK 14861
Query: 534 LTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQ 593
++T+L G Y + A N G G + + P
Sbjct: 14862 YSVTKLIEGKEYLFRVRAENRFGPGPPCV---------------------------SKPL 14894
Query: 594 SSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWI 653
+ P PP+APD+P + + S+ V W + G PI + +E +++ W
Sbjct: 14895 VAKDP----FGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGSPILGYWLEKREVNST-HWS 14949
Query: 654 LATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPV 713
++ + L + GL +G +Y FRV A N G + S PS P + P+
Sbjct: 14950 RVNKSL-LNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDP--------KTAHDPI 15000
Query: 714 A--GPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGD 771
+ GP I + TTI L+W PA N I G+++ + ++ S + M++
Sbjct: 15001 SPPGPPIPRVTDTSSTTIELEW-EPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVR 15059
Query: 772 KYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQP 831
+Y ++ ++ Y +++ N GE G PG P T+A PQ
Sbjct: 15060 QY--TVKEIREGADYKLRVSAVNAAGE-----------------GPPGETQPVTVAEPQE 15100
Query: 832 PLPETIERPV--GTGAMVARSSDLPYLIVG 859
P ++ V G M ++ +P ++ G
Sbjct: 15101 PPAVELDVSVKGGIQIMAGKTLRIPAVVTG 15130
Score = 84.3 bits (207), Expect = 6e-16
Identities = 87/421 (20%), Positives = 164/421 (38%), Gaps = 25/421 (5%)
Query: 32 LNEVPQVTVQPASTVQKPGGTVILGCVVEPPR-MNVTWRLNGKEL-NGSDDALGVLITHG 89
+ E P +P S PG V L + + + W KEL +G +
Sbjct: 4202 VQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALES 4261
Query: 90 TLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIA 149
+L + + G Y C AG V A + + F ++ + +G+ +A
Sbjct: 4262 SLELYLVKTSDSGTYTCKVSNVAGGV-ECSANLFVKEPATFVEKLEPSQLLKKGDATQLA 4320
Query: 150 CHLPESHPKAQVRYSVKQEWLEASRGNYLIMPS-GNLQIVNASQEDEGMYKCAAYNPVTQ 208
C + + P ++ +E E+S+ + S L++ + ED G Y C A N
Sbjct: 4321 CKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQN---- 4376
Query: 209 EVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDG 268
E + S + V+ S + E + I V K ++L +G PP +TW KD
Sbjct: 4377 EAGSDHCSSIVIVKESP------YFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDN 4430
Query: 269 SSVTGYNKTRFLLSNLLIDTT----SEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPE 324
+ + K + + + L+ D+G Y+C N V G+++ V + EPP
Sbjct: 4431 TILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEV---GSSICSARVTLREPPS 4487
Query: 325 VTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRR----ALRVLS 380
++ G +A ++G+ P +V WL+++ + +R++ +L +
Sbjct: 4488 FIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSG 4547
Query: 381 MGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQ 440
+ + +G Y C A+N+ G L P+ ++ G P K ++
Sbjct: 4548 IEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKE 4607
Query: 441 M 441
+
Sbjct: 4608 I 4608
Score = 84.3 bits (207), Expect = 6e-16
Identities = 103/446 (23%), Positives = 164/446 (36%), Gaps = 66/446 (14%)
Query: 28 CFADLNEVPQVTVQPASTVQKP-------GGTVILGCVVE-PPRMNVTWRLNGKELNGSD 79
CFA L+ ++PA+ V+KP G T L C V P ++ W +GKEL SD
Sbjct: 7576 CFATLS-----VLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELT-SD 7629
Query: 80 DALGVLITHGTLVITALN-------------NHTVGRYQCVARMPAGAVASVPATVTLAN 126
+ + + + +N + VG+ C A + +VP + T
Sbjct: 7630 NKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSD-RTVPPSFTRKL 7688
Query: 127 LQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGN-YLIMPSGN- 184
+ L G++ V+ C + S P + S E E S G Y + N
Sbjct: 7689 KETNGLS---------GSSVVMECKVYGSPP---ISVSWFHEGNEISSGRKYQTTLTDNT 7736
Query: 185 --LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIV 242
L + + D G Y C A N SD + E + P+ ++
Sbjct: 7737 CALTVNMLEESDSGDYTCIATN--------MAGSDECSAPLTVREPPSFVQKPDPMDVLT 7788
Query: 243 TKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDT----TSEEDSGTYR 298
G ++ + G PP V+W K S + ++ L + + + SG Y
Sbjct: 7789 --GTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYT 7846
Query: 299 CMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLR 358
C+ N G+ LY + P + L+ I G+ L G PP SV W +
Sbjct: 7847 CIVSNEAGKASCTTHLY---IKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKK 7903
Query: 359 NAVPLISSQRLRLS----RRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSIT 414
N + + SQR ++ L + S ED G Y C EN G Q+ P
Sbjct: 7904 NGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYF 7963
Query: 415 PRLWQDAELATGTPPVSPSKL-GNPE 439
+ + +++ G +L G PE
Sbjct: 7964 VKQLEPVKVSVGDSASLQCQLAGTPE 7989
Score = 83.6 bits (205), Expect = 1e-15
Identities = 94/406 (23%), Positives = 151/406 (37%), Gaps = 45/406 (11%)
Query: 32 LNEVPQVTVQPASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDD---ALGVLIT 87
+ E P P S PG ++ V+ P V W +EL + +L +T
Sbjct: 6830 VQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVT 6889
Query: 88 HGTLVITALNNHTVGRYQCVARMPAGAVASV-------PATVTLANLQDFKLDVQHVIEV 140
L + + G Y C+ AG+ + PAT + L DF ++ I +
Sbjct: 6890 E--LELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATF-VKRLADFSVETGSPIVL 6946
Query: 141 DEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIM---PSGNLQIVNASQEDEGM 197
+ T P V + +K E+L + I S L+I+ ++ ED
Sbjct: 6947 EATYTGT---------PPISVSW-IKDEYLISQSERCSITMTEKSTILEILESTIEDYAQ 6996
Query: 198 YKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGI 257
Y C N Q++ S E I P E ++ G+ L+C G
Sbjct: 6997 YSCLIENEAGQDI--------CEALVSVLEPPYFIEPLEHVEAVI--GEPATLQCKVDGT 7046
Query: 258 PPPRVTWAKDGSSVTGYNKTRFLLSN----LLIDTTSEEDSGTYRCMADNGVGQPGAAVI 313
P R++W K+ + + + N L+I+ D G Y C ADN VG ++ +
Sbjct: 7047 PEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAV 7106
Query: 314 LYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSR 373
L PP +L + G C + G+ P V W ++ V L L+ S
Sbjct: 7107 LVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSF 7166
Query: 374 ----RALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITP 415
L++L G Y C A N +G+A + +L S + P
Sbjct: 7167 VHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPP 7212
Score = 83.2 bits (204), Expect = 1e-15
Identities = 96/406 (23%), Positives = 156/406 (38%), Gaps = 31/406 (7%)
Query: 24 ATAGCFADLNEVPQVTVQPAST-VQKPGGTVILGC-VVEPPRMNVTWRLNGKELNGSDDA 81
AT+ + E PQ +P+ V + G + C + P++ V+W L+G E+
Sbjct: 4849 ATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKH 4908
Query: 82 LGVLITHG--TLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIE 139
G+ G T I+ G Y C AR AG AS + + F +++ V E
Sbjct: 4909 -GISFIDGLATFQISGARVENSGTYVCEARNDAGT-ASCSIELKVKEPPTFIRELKPV-E 4965
Query: 140 VDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLI--MPSGNLQIVNASQEDEGM 197
V + + + C + + P +V + + +S+ L + NL I D G
Sbjct: 4966 VVKYSDVELECEVTGT-PPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGE 5024
Query: 198 YKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGI 257
Y+C N G S R + E I E T ++ S + +G
Sbjct: 5025 YQCIVSN--------EGGSCSCSTRVALKEPPSFIKKIENTTTVLKS--SATFQSTVAGS 5074
Query: 258 PPPRVTWAKDGSSVTGYNKTRFL----LSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVI 313
PP +TW KD + + ++ L I + SG Y C A N G
Sbjct: 5075 PPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAF 5134
Query: 314 LYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSR 373
L V EP ++ + + + L C V G P V WL++ ++ S+ +S
Sbjct: 5135 LL---VQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSF 5191
Query: 374 R----ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITP 415
+ R+ S+ +D G Y EN+ GS+ LR +I P
Sbjct: 5192 ENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPP 5237
Score = 83.2 bits (204), Expect = 1e-15
Identities = 116/566 (20%), Positives = 201/566 (35%), Gaps = 132/566 (23%)
Query: 268 GSSVTGY--------NKTRFLLSNLLIDTTSEE----DSGTYRCMADN--GVGQPGAAVI 313
GS + GY NK + ++ +L + ++++ T+R A+N G G P +
Sbjct: 19912 GSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTPSEITV 19971
Query: 314 LYNVQVFEPPEVTMELSQL--VIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL 371
+ V P L L + + +L ++G P PSV W + PL + R+ +
Sbjct: 19972 VARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSV 20031
Query: 372 SRRALR----VLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGT 427
A+ V D G Y +N G+ + ++
Sbjct: 20032 ESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVV------------------ 20073
Query: 428 PPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTD 487
G+P +P P + +
Sbjct: 20074 ----------------GKPGIPTGPIKFDEVT--------------------------AE 20091
Query: 488 SYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEV 547
+ L W P + G + I Y+++ R N+ W + +TRL G Y
Sbjct: 20092 AMTLKWAPPKDDGG-SEITNYILEKRDSVNNK--WVTCASAVQKTTFRVTRLHEGMEYTF 20148
Query: 548 EMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPE 607
++A N G G+ G + +P I+A + P+
Sbjct: 20149 RVSAENKYGVGE--------GLKSEP-IVARHPFDV----------------------PD 20177
Query: 608 APDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSV 666
AP P I SV +TW P+ GG PI + +E+K+ + W A P
Sbjct: 20178 APPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSL-LWKRANKT-PIRMRDF 20235
Query: 667 EITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNE 726
++TGL +G Y+FRV A+N+ G +PS PS P V P+ P +
Sbjct: 20236 KVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALD--------PIDPPGKPEVINITR 20287
Query: 727 TTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSY 786
++ L W P + + G+ + R D + S K + V + +++ L Y
Sbjct: 20288 NSVTLIWTE-PKYDGGHKLTGYIVEKR--DLPSKSWMKANHVNVPECAFTVTDLVEGGKY 20344
Query: 787 DIKMQCFNEGG----ESEFSNVMICE 808
+ +++ N G SE + +IC+
Sbjct: 20345 EFRIRAKNTAGAISAPSESTETIICK 20370
Score = 82.8 bits (203), Expect = 2e-15
Identities = 97/402 (24%), Positives = 154/402 (38%), Gaps = 35/402 (8%)
Query: 20 CLLLATAGCFADLNEV----PQVTVQPASTVQKPGG--TVILGCVVEPPRMNVTWRLNGK 73
CL AG + E+ P ++ A +Q G + V P + W +G+
Sbjct: 3996 CLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGR 4055
Query: 74 ELNGSDD-ALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKL 132
L S + L + H G+Y G+ +S T T+ +
Sbjct: 4056 PLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGS-SSCETTFTVLDRDIAPF 4114
Query: 133 DVQHVIEVDE--GNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMP-SGNLQIVN 189
+ + VD T + C + S P + +E + R + + +L+I+
Sbjct: 4115 FTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIR 4174
Query: 190 ASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLI 249
D G + C A T V + SS L V+ E + P ++ ++ G ++
Sbjct: 4175 VDMNDAGNFTCRA----TNSVGSKDSSGALIVQ----EPPSFVTKPGSKDVL--PGSAVC 4224
Query: 250 LECVASGIPPPRVTWAKDGSSVTG----YNKTRFLLSNLLIDTTSEEDSGTYRCMADNGV 305
L+ G P + W K + Y L S+L + DSGTY C N
Sbjct: 4225 LKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVA 4284
Query: 306 GQPGAAVILYNVQVFEPPEVT--MELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPL 363
G + L+ V EP +E SQL + G + +L C+V G PP + W N +
Sbjct: 4285 GGVECSANLF---VKEPATFVEKLEPSQL-LKKGDATQLACKVTGTPPIKITWFANDREI 4340
Query: 364 ISSQRLRLS----RRALRVLSMGPEDEGVYQCMAENEVGSAH 401
S + R+S LR+ +G ED G Y C A+NE GS H
Sbjct: 4341 KESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDH 4382
Score = 78.2 bits (191), Expect = 4e-14
Identities = 89/381 (23%), Positives = 151/381 (39%), Gaps = 32/381 (8%)
Query: 48 KPGGTVILGCVVEPPR-MNVTWRLNGKELNGSDDALGVLITHGTLVITALNN--HTVGRY 104
+PG ++IL ++VTW+ +G + S+ ++ T T ++ LN+ G+Y
Sbjct: 5998 EPGKSIILESTYTGTLPISVTWKKDGFNITTSEKC-NIVTTEKTCILEILNSTKRDAGQY 6056
Query: 105 QCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHL---PE---SHPK 158
C AG TL + + +E G++ + C + PE S K
Sbjct: 6057 SCEIENEAGRDVCGALVSTLE--PPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYK 6114
Query: 159 AQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDR 218
+ E+ N + + I D G Y C A N + +S + R
Sbjct: 6115 GDTKLRPTPEYRTYFTNNVATLVFNKVNI-----NDSGEYTCKAENSIG--TASSKTVFR 6167
Query: 219 LRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYN--K 276
++ R+ AR + + I T G + L C +G P +V W +DG + +
Sbjct: 6168 IQERQLPPSFAR-----QLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQ 6222
Query: 277 TRFL--LSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVI 334
T F+ ++ L I T SG Y C A N +G ++ L + + P ++ + +
Sbjct: 6223 TSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDV 6282
Query: 335 PWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL----SRRALRVLSMGPEDEGVYQ 390
G+SA C V G P + W ++ + + + LR+L +G D G Y
Sbjct: 6283 IAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYT 6342
Query: 391 CMAENEVGSAHAVVQLRTSRP 411
C A N+VG QL P
Sbjct: 6343 CQATNDVGKDMCSAQLSVKEP 6363
Score = 78.2 bits (191), Expect = 4e-14
Identities = 131/554 (23%), Positives = 200/554 (36%), Gaps = 131/554 (23%)
Query: 169 WLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEA 228
WL+A+ N L + +++ ++ A N S SD + R EA
Sbjct: 21403 WLKANFSNIL---ENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCR-DDVEA 21458
Query: 229 ARIIYPPEAQ-TIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLL----SN 283
+I + + T+I+ G++ LE SG PPP + W+KDG + G K + +N
Sbjct: 21459 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTN 21518
Query: 284 LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLT 343
L+ ++ DSG Y A N G A ++NV+V + P
Sbjct: 21519 LVNKDSTRRDSGAYTLTATN---PGGFAKHIFNVKVLDRP-------------------- 21555
Query: 344 CEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAV 403
PP L AV ++S++ LS P D+G + H +
Sbjct: 21556 -----GPPEGPL----AVTEVTSEKCVLS-------WFPPLDDGGAKI--------DHYI 21591
Query: 404 VQLR-TSRPSITPRLWQDAELATGTPPVSPSKL--GNPEQMLR---------GQPALPRP 451
VQ R TSR + W + + +KL GN E + R G+P P
Sbjct: 21592 VQKRETSRLA-----WTNVASEVQVTKLKVTKLLKGN-EYIFRVMAVNKYGVGEPLESEP 21645
Query: 452 PTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVK 511
+V P P P + + T DS + W + G + I+ Y+V+
Sbjct: 21646 VLAVNPYGPPDPPKNPE------------VTTITKDSMVVCW-GHPDSDGGSEIINYIVE 21692
Query: 512 HRKVTNSSDDWTISGIPANQHRLT-----LTRLDPGSLYEVEMAAYNCAGEGQTAMVTFR 566
R + W I N+ LT ++ L G YE + A N AG
Sbjct: 21693 RR--DKAGQRW----IKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGIS-------- 21738
Query: 567 TGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTW 626
SP S + P P P + S +S+ + W
Sbjct: 21739 ----------------------APSPTSPFYKACDTVFKPGPPGNPRVLDTSRSSISIAW 21776
Query: 627 -IPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALN 685
P +GG I + VE L + +W + T S ITGL + YK R+ A+N
Sbjct: 21777 NKPIYDGGSEITGYMVEI-ALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMN 21835
Query: 686 MLGESEPS-APSRP 698
G EP+ P P
Sbjct: 21836 SEGLGEPALVPGTP 21849
Score = 77.8 bits (190), Expect = 5e-14
Identities = 61/248 (24%), Positives = 96/248 (38%), Gaps = 16/248 (6%)
Query: 238 QTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLS------NLLIDTTSE 291
Q+++V +G + E SG P P V+W +DG ++ +S L I ++
Sbjct: 13 QSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTK 72
Query: 292 EDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPP 351
+SG Y A NG GQ + L PP L + + G +L V G P
Sbjct: 73 ANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPT 132
Query: 352 PSVLWLRNAVPLISSQRLRLSRR----ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLR 407
P V + R+ + SS ++S+ +L + PED G Y A N VG A + +L
Sbjct: 133 PVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELL 192
Query: 408 TSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKG 467
P + + T +S S+ E+ + S+ G G
Sbjct: 193 VQGEEEVPA--KKTKTIVSTAQISESRQTRIEKKIEAH----FDARSIATVEMVIDGAAG 246
Query: 468 QGAPAEAP 475
Q P + P
Sbjct: 247 QQLPHKTP 254
Score = 77.8 bits (190), Expect = 5e-14
Identities = 106/464 (22%), Positives = 168/464 (36%), Gaps = 96/464 (20%)
Query: 286 IDTTSEEDSGTYRCMADN--GVGQPGAAVILYNVQVFEP-PEV---TMELSQLVIPWGQS 339
+ + +E + +R A N GV +P V VQ P + TM + +P G+
Sbjct: 29696 VTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRP 29755
Query: 340 AKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRA----LRVLSMGPEDEGVYQCMAEN 395
+L + G PPP+ W L S+R+ + L + D G Y +N
Sbjct: 29756 VELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKN 29815
Query: 396 EVGSAHAVVQL----------------RTSRPSITPRLWQDAELATGTP----------- 428
G+ +++ SIT W+ EL G P
Sbjct: 29816 VTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITIS-WEPPELDGGAPLSGYVVEQRDA 29874
Query: 429 ------PVSPSKLGNPEQMLR---GQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILS 479
PVS S + + R G + R V + G Q E +
Sbjct: 29875 HRPGWLPVSESVTRSTFKFTRLTEGNEYVFR----VAATNRFGIGSYLQSEVIECRSSIR 29930
Query: 480 SPRTSKT--------DSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWT-ISGIPAN 530
P +T D L W P E G + + Y+V+ ++V +D W ++ +P
Sbjct: 29931 IPGPPETLQIFDVSRDGMTLTWYPP-EDDGGSQVTGYIVERKEVR--ADRWVRVNKVPVT 29987
Query: 531 QHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGA 590
R T L G YE + A N G G+ + RP I+A DP
Sbjct: 29988 MTRYRSTGLTEGLEYEHRVTAINARGSGKPS--------RPSKPIVAM--------DP-- 30029
Query: 591 SPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTW-IPRGNGGFPIQSFRVEYKKLKKV 649
++PP P P ++ + TSV + W +P GG + + +E +K+ +
Sbjct: 30030 ------------IAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQ- 30076
Query: 650 GDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPS 693
+W + P +T L +G Y+FRV A N G EP+
Sbjct: 30077 HEWTKCNTT-PTKIREYTLTHLPQGAEYRFRVLACNAGGPGEPA 30119
Score = 77.4 bits (189), Expect = 7e-14
Identities = 97/396 (24%), Positives = 150/396 (37%), Gaps = 49/396 (12%)
Query: 39 TVQPASTVQKPGGTVILGCVVEPPR-MNVTWRLNGKELNGSDDALGVLITHGTLV---IT 94
T++PA V+ G +L C V ++W + K++ S L + +LV I
Sbjct: 3836 TLEPADIVR--GTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYR--LFSQKSLVCLEIF 3891
Query: 95 ALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPE 154
+ N+ VG Y+CV G + AT L F V +I + G T + +
Sbjct: 3892 SFNSADVGEYECVVANEVGKCGCM-ATHLLKEPPTFVKKVDDLIALG-GQTVTLQAAVRG 3949
Query: 155 SHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQ-----------IVNASQEDEGMYKCAAY 203
S P + W+ +G +I G ++ I + G Y C A
Sbjct: 3950 SEP-------ISVTWM---KGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAE 3999
Query: 204 NPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVT 263
N E + S L V+ E A+II A+ I VT G LE +G P +
Sbjct: 4000 N----EAGSQTSVGELIVK----EPAKII--ERAELIQVTAGDPATLEYTVAGTPELKPK 4049
Query: 264 WAKDGSSVTGYNKTRFLLSN----LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQV 319
W KDG + K R N L + DSG Y N VG +
Sbjct: 4050 WYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDR 4109
Query: 320 FEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLS----RRA 375
P T L + + +L C++ G+ P V W ++ + +S R R++ +
Sbjct: 4110 DIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTAS 4169
Query: 376 LRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRP 411
L ++ + D G + C A N VGS + L P
Sbjct: 4170 LEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEP 4205
Score = 77.4 bits (189), Expect = 7e-14
Identities = 104/472 (22%), Positives = 168/472 (35%), Gaps = 120/472 (25%)
Query: 240 IIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYN----KTRFLLSNLLIDTTSEEDSG 295
++V G ++ + G+P P W DGS + +T S L I D+G
Sbjct: 17520 LVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTG 17579
Query: 296 TYRCMADNGVGQPGAAVILYNVQVFEPP-------EVTMELSQLVIPW------GQSAKL 342
Y+ N G AV L + V PP +VT E + I W G S +
Sbjct: 17580 EYQITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPE--HMTISWQPPKDDGGSPVI 17637
Query: 343 TCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHA 402
V W ++SS S+ L++ + E V++ AEN++G
Sbjct: 17638 NYIVEKQDTRKDTW-----GVVSSGS---SKTKLKIPHLQKGCEYVFRVRAENKIG---- 17685
Query: 403 VVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQC 462
+ P L TP V+ K P
Sbjct: 17686 ----------VGPPL-------DSTPTVAKHKFSPP------------------------ 17704
Query: 463 PGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDW 522
+P P++ + T S+ L P+ +G +PI Y ++ R+VT W
Sbjct: 17705 -------SPPGKPVVTDITENAATVSWTL---PKSDGG--SPITGYYMERREVTGK---W 17749
Query: 523 T-ISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQ 581
++ P + +T L G+ YE + A N AG
Sbjct: 17750 VRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAG------------------------- 17784
Query: 582 QIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFR 640
+ + P + P + +P + PP P P + S + + W P +GG PI +
Sbjct: 17785 -LSKPSPSSDPIKACRP----IKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYV 17839
Query: 641 VEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEP 692
VE +K W + + + GL +G Y+FR++A N++GE EP
Sbjct: 17840 VECQK-PGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEP 17890
Score = 77.0 bits (188), Expect = 9e-14
Identities = 92/383 (24%), Positives = 141/383 (36%), Gaps = 36/383 (9%)
Query: 46 VQKPGGTVILGCVVEPPRMNVTWRLNGKELNGSDDALGVLITH-GTLVITALNNHTVGRY 104
V K ++L V P +TW + L + H +L I G Y
Sbjct: 4404 VLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEY 4463
Query: 105 QCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYS 164
QC G+ + A VTL F ++ + G TA L S P
Sbjct: 4464 QCRVTNEVGS-SICSARVTLREPPSFIKKIESTSSL-RGGTAAFQATLKGSLP------- 4514
Query: 165 VKQEWL----EASRGNYLIMPSGN----LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSS 216
+ WL E + + + M N L + + +G Y C A K
Sbjct: 4515 ITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQA--------KNDAGI 4566
Query: 217 DRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNK 276
R S E A I EA +I VT+G L+ SG W KDG +T +K
Sbjct: 4567 QRCSALLSVKEPATIT--EEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSK 4624
Query: 277 TRFLLSN----LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQL 332
+ +++ L I +T ++DSG Y N VG+ + + + PP T +L ++
Sbjct: 4625 YKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKM 4684
Query: 333 VIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLS----RRALRVLSMGPEDEGV 388
G L C V G+ P S+ W ++ + +S++ + S L + + D G
Sbjct: 4685 DSIKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGT 4744
Query: 389 YQCMAENEVGSAHAVVQLRTSRP 411
Y C A N+ G L P
Sbjct: 4745 YTCSATNKAGHNQCSGHLTVKEP 4767
Score = 76.6 bits (187), Expect = 1e-13
Identities = 94/426 (22%), Positives = 165/426 (38%), Gaps = 44/426 (10%)
Query: 17 TLACLLLATAG---CFADLNEVPQVT----VQPASTVQKPGGTVILGCVVEPPRMNVTWR 69
T C + AG C A+L T ++P+ ++K T + V P + +TW
Sbjct: 4275 TYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWF 4334
Query: 70 LNGKELN-GSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLAN-- 126
N +E+ S + + + L +T + G Y C A+ AG+ + +
Sbjct: 4335 ANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPY 4394
Query: 127 -LQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSG-- 183
++FK ++ + E D A +A P ++ + L + R +
Sbjct: 4395 FTKEFK-PIEVLKEYDVMLLAEVA-----GTPPFEITWFKDNTILRSGRKYKTFIQDHLV 4448
Query: 184 NLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVT 243
+LQI+ D G Y+C VT EV +S S R+ +R + +I ++
Sbjct: 4449 SLQILKFVAADAGEYQCR----VTNEVGSSICSARVTLREPPSFIKKI------ESTSSL 4498
Query: 244 KGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN----LLIDTTSEEDSGTYRC 299
+G + + G P VTW KD +T + R N L + + G Y C
Sbjct: 4499 RGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVC 4558
Query: 300 MADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRN 359
A N G + +L V EP +T E + + G A L + G + W ++
Sbjct: 4559 QAKNDAGIQRCSALL---SVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKD 4615
Query: 360 AVPLISSQRLRLSRR----ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRT----SRP 411
L + ++S L+++S +D G Y +N+VG + ++ P
Sbjct: 4616 GQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPP 4675
Query: 412 SITPRL 417
S T +L
Sbjct: 4676 SFTKKL 4681
Score = 76.3 bits (186), Expect = 2e-13
Identities = 99/428 (23%), Positives = 155/428 (36%), Gaps = 62/428 (14%)
Query: 33 NEVPQVTVQPASTVQKPGG-TVILG--CVVE-----PPRMNVTWRLNGKELNGSD----- 79
N + ++PA V+K G TV +G C +E P ++V W +GK L S
Sbjct: 5694 NMATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFS 5753
Query: 80 -----DALGVLITH----GTLVITALNNHTVGRYQCVARMPAGAVASVPA-TVTLANLQD 129
+L +L GT NN VG+ C A + A P+ T L N
Sbjct: 5754 FYNKISSLRILSVERQDAGTYTFQVQNN--VGKSSCTAVVDVSDRAVPPSFTRRLKNTGG 5811
Query: 130 FKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGN---LQ 186
G + ++ C + S P + + K + + ++ Y S N LQ
Sbjct: 5812 VL-----------GASCILECKVAGSSPISVAWFHEKTKIVSGAK--YQTTFSDNVCTLQ 5858
Query: 187 IVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQ 246
+ + D G Y C A N SD R + E + PE ++ G+
Sbjct: 5859 LNSLDSSDMGNYTCVAANVA--------GSDECRAVLTVQEPPSFVKEPEPLEVL--PGK 5908
Query: 247 SLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLID----TTSEEDSGTYRCMAD 302
++ V G PP +V W + + ++ + + + SG Y C+
Sbjct: 5909 NVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVS 5968
Query: 303 NGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVP 362
N GQ L+ V EP LS + G+S L G P SV W ++
Sbjct: 5969 NNAGQASCTTRLF---VKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFN 6025
Query: 363 LISSQRLRLSRRA----LRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLW 418
+ +S++ + L +L+ D G Y C ENE G + T P
Sbjct: 6026 ITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTEL 6085
Query: 419 QDAELATG 426
+ E A G
Sbjct: 6086 EPLEAAVG 6093
Score = 76.3 bits (186), Expect = 2e-13
Identities = 112/463 (24%), Positives = 170/463 (36%), Gaps = 88/463 (19%)
Query: 291 EEDSGTYRCMADNGVGQPGAAVILYNVQVFE---PPEVTMEL-SQLVIPWGQSAKLTCEV 346
E D+ YR A N VGQ + + + PP + ++ +L I G++ LT
Sbjct: 16783 EGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRY 16842
Query: 347 RGNPPPSVLWLRNAVPLISSQRLRLSRR----ALRVLSMGPEDEGVYQCMAENEVGSAHA 402
G P P V W ++ ++ R + AL + D G Y + EN GS
Sbjct: 16843 SGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKG 16902
Query: 403 VVQLRT---SRPSITP----RLWQDAELATGTPPVSP--SKLGN---------------- 437
Q+ P + P + +D + + PP+ SK+ N
Sbjct: 16903 FCQVNVVDRPGPPVGPVSFDEVTKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPV 16962
Query: 438 ----------PEQMLRGQPALPR--PPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSK 485
++L G+ + R G + P P P ++
Sbjct: 16963 TSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTE 17022
Query: 486 T--DSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGS 543
DS + W H+G PI Y+++ R+ S W R+T + P +
Sbjct: 17023 VTKDSALVTWNKPHDGG--KPITNYILEKRETM--SKRWA---------RVTKDPIHPYT 17069
Query: 544 LYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRL 603
+ V C + E S E +I DP SP S +
Sbjct: 17070 KFRVPDLLEGC-----------------QYEFRVSAENEIGIGDP--SPPSKPVFAKDPI 17110
Query: 604 SPPEAPDRPTISTASETSVYVTWIP-RGNGGFPIQSFRVEYKKLKKVGD--WILATSAIP 660
+ P P P + SV +TW P R +GG I + VEY+K VGD W A P
Sbjct: 17111 AKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQK---VGDEEWRRANHT-P 17166
Query: 661 PS--RLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVV 701
S ++TGL G +YKFRV A+N GES+P+ P +V
Sbjct: 17167 ESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLV 17209
Score = 75.5 bits (184), Expect = 3e-13
Identities = 79/332 (23%), Positives = 135/332 (40%), Gaps = 49/332 (14%)
Query: 471 PAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPAN 530
P E P+ ++ K L W P + G A I +Y+++ R+ + S WT
Sbjct: 24804 PPEGPLKVTGVTAEKC---YLAWNPPLQDGG-ANISHYIIEKRETSRLS--WTQVSTEVQ 24857
Query: 531 QHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGA 590
+T+L PG+ Y + A N G G+ +
Sbjct: 24858 ALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLE---------------------------S 24890
Query: 591 SPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKV 649
P ++ P PP P P +S ++ S+ VTW P +GG I+ + +E K+ K+
Sbjct: 24891 GPVTACNP----YKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILE-KRDKEG 24945
Query: 650 GDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVY 709
W L + +TGL +G SY+FRV A N G EPS PS Y
Sbjct: 24946 VRWTKCNKKTLTD-LRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFY--RACDALYP 25002
Query: 710 ERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDM-V 768
P + P +T T + +++ L W P + P+ G+ + + +D + +
Sbjct: 25003 PGPPSNPKVTDT---SRSSVSLAWSK-PIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGL 25058
Query: 769 EGDKYWHSISHLQPETSYDIKMQCFNEGGESE 800
+G ++ +++ L+ T Y+ ++ N G E
Sbjct: 25059 QGKQF--TVTKLKENTEYNFRICAINSEGVGE 25088
Score = 75.1 bits (183), Expect = 3e-13
Identities = 99/434 (22%), Positives = 154/434 (35%), Gaps = 61/434 (14%)
Query: 40 VQPASTVQKP-------GGTVILGCVVE-PPRMNVTWRLNGKELNG-SDDALGVLITHGT 90
++PA ++KP G L CVV P ++ W +G+EL+ S + + +
Sbjct: 6642 LEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKVAS 6701
Query: 91 LVITALNNHTVGRYQCVARMPAG------AVASVPATVTLANLQDFKLDVQHVIEVDEGN 144
L I G Y + G +V V + ++ K DV ++ G
Sbjct: 6702 LKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLK-DVNAIL----GA 6756
Query: 145 TAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMP-------SGNLQIVNAS---QED 194
+ V+ C + S P + W + GN ++ S N+ +N S D
Sbjct: 6757 SVVLECRVSGSAP-------ISVGWFQD--GNEIVSGPKCQSSFSENVCTLNLSLLEPSD 6807
Query: 195 EGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVA 254
G+Y C A N SD + E P++ + V G SL V
Sbjct: 6808 TGIYTCVAANVA--------GSDECSAVLTVQEPPSFEQTPDS--VEVLPGMSLTFTSVI 6857
Query: 255 SGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEE----DSGTYRCMADNGVGQPGA 310
G PP +V W K + L + + + E +SG Y C+ N G
Sbjct: 6858 RGTPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASC 6917
Query: 311 AVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLR 370
L+ V EP L+ + G L G PP SV W+++ + S+R
Sbjct: 6918 TTHLF---VKEPATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCS 6974
Query: 371 LS----RRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATG 426
++ L +L ED Y C+ ENE G + P + E G
Sbjct: 6975 ITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIG 7034
Query: 427 TPPVSPSKL-GNPE 439
P K+ G PE
Sbjct: 7035 EPATLQCKVDGTPE 7048
Score = 75.1 bits (183), Expect = 3e-13
Identities = 103/455 (22%), Positives = 174/455 (38%), Gaps = 88/455 (19%)
Query: 290 SEEDSGTYRCMADNGVG------QPGAAVILYNVQVFEPPEVTME---LSQLVIPWGQSA 340
S D +R +A N VG Q ++ + V PP V L+I G+S
Sbjct: 27919 SPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENV--PPIVEFGPEYFDGLIIKSGESL 27976
Query: 341 KLTCEVRGNPPPSVLWLRNAVPLISSQRLR----LSRRALRVLSMGPEDEGVYQCMAENE 396
++ V+G P P V W ++ V + + L +L V + GVY A+N
Sbjct: 27977 RIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNA 28036
Query: 397 VGSAHAVVQLR--------------TSRPSITPRLWQDAELATGTPPVSPSKLGNPEQM- 441
GSA A ++++ T+ LW DA L G P++ + E
Sbjct: 28037 SGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSR 28096
Query: 442 -----------LRGQPALPRPPTSVGPASPQCPGEKGQGAPAEA-PII------------ 477
+ A+ + + G G P ++ P++
Sbjct: 28097 LAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPG 28156
Query: 478 LSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLT 537
+ P +S L W R E G + I Y+++ R+ ++ IS P ++ R +T
Sbjct: 28157 IPEPSNITGNSITLTW-ARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVT 28215
Query: 538 RLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQ 597
L G+ YE + A N AG G + ++ + I+ +P
Sbjct: 28216 GLTEGNEYEFHVMAENAAGVGPASGIS----------------RLIKCREP--------- 28250
Query: 598 PDHGRLSPPEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKVGDWILAT 656
++PP P ++ S+T+V + W P +GG I + +E K +GDW
Sbjct: 28251 -----VNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCK-ADLGDW-HKV 28303
Query: 657 SAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESE 691
+A + +T L+ G YKFRV A+N G+ +
Sbjct: 28304 NAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGD 28338
Score = 74.3 bits (181), Expect = 6e-13
Identities = 61/232 (26%), Positives = 88/232 (37%), Gaps = 18/232 (7%)
Query: 185 LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSS---------DRLRVRRSTAEAARIIYPP 235
L+I A EDEG Y A N V Q T+ S +R+ A +
Sbjct: 3401 LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKR 3460
Query: 236 EAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRF----LLSNLLIDTTSE 291
+ + + V G C P R W K G + +K +S+L I T
Sbjct: 3461 KIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQV 3520
Query: 292 EDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPP 351
D G Y C A N G L + + PP L G++AK C V G P
Sbjct: 3521 VDCGEYTCKASNEYGSVSCTATLTVTEAY-PPTFLSRPKSLTTFVGKAAKFICTVTGTPV 3579
Query: 352 PSVLWLRNAVPLISSQRLRLS----RRALRVLSMGPEDEGVYQCMAENEVGS 399
+W ++ L S R+S + L + ++ +D GVY C A N+ G+
Sbjct: 3580 IETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGA 3631
Score = 74.3 bits (181), Expect = 6e-13
Identities = 117/545 (21%), Positives = 196/545 (35%), Gaps = 123/545 (22%)
Query: 169 WLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEA 228
W++AS N L + ++ ++ A N + S SS + R
Sbjct: 24649 WMKASFTNVL---ETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAP 24705
Query: 229 ARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYN-----KTRFLLSN 283
+ P I+V G++ +LE G P P V W+KDG + K+ +
Sbjct: 24706 NASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTT 24765
Query: 284 LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLT 343
L++ D G Y N G + + + PPE ++++ G +A+
Sbjct: 24766 LVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVT------GVTAE-K 24818
Query: 344 CEVRGNPP--------PSVLWLRNAVPLISSQRLRLSRRAL--RVLSMGPEDEGVYQCMA 393
C + NPP + + +S ++ +AL +V + P +E +++ MA
Sbjct: 24819 CYLAWNPPLQDGGANISHYIIEKRETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMA 24878
Query: 394 ENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPT 453
N+ G G+P P T
Sbjct: 24879 VNKYGI--------------------------------------------GEPLESGPVT 24894
Query: 454 SVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHR 513
+ P P PG P P + + + DS + W R G I Y+++ R
Sbjct: 24895 ACNPYKP--PG------PPSTPEVSAITK----DSMVVTWA-RPVDDGGTEIEGYILEKR 24941
Query: 514 KVTNSSDDWT-ISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPK 572
WT + RL +T L G YE +AA N AG G+ +
Sbjct: 24942 D--KEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPS----------- 24988
Query: 573 PEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWI-PRGN 631
+P ++ L PP P P ++ S +SV + W P +
Sbjct: 24989 --------------EPSVFYRACDA-----LYPPGPPSNPKVTDTSRSSVSLAWSKPIYD 25029
Query: 632 GGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVE---ITGLEKGTSYKFRVRALNMLG 688
GG P++ + VE K+ +W T+ PP+ L + +T L++ T Y FR+ A+N G
Sbjct: 25030 GGAPVKGYVVEVKEAA-ADEW---TTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEG 25085
Query: 689 ESEPS 693
EP+
Sbjct: 25086 VGEPA 25090
Score = 73.6 bits (179), Expect = 1e-12
Identities = 128/627 (20%), Positives = 238/627 (37%), Gaps = 100/627 (15%)
Query: 223 RSTAEAARIIYPPE----AQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTR 278
+S AE I P E + VT+ + C S V W ++G + K +
Sbjct: 12811 KSVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSR-EKANVKWYRNGREIKEGKKYK 12869
Query: 279 F----LLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVI 334
F + L+I +D Y C ++ + V V++ PP+ +E
Sbjct: 12870 FEKDGSIHRLIIKDCRLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDILEAP---- 12925
Query: 335 PWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRA----LRVLSMGPEDEGVYQ 390
G E+ + V WLRN + ++ + ++ L++ + P D+G Y+
Sbjct: 12926 --GADVVFLAELNKDKV-EVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYR 12982
Query: 391 CMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTP-----PVSPSKLGNPEQMLRGQ 445
+A+++ A A ++L + T QD + G P P E +
Sbjct: 12983 FIAKDK--EARAKLELAAAPKIKTAD--QDLVVDVGKPLTMVVPYDAYPKAEAEWFKENE 13038
Query: 446 PALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSK-------------------- 485
P + + + E +G I+L +
Sbjct: 13039 PLSTKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEV 13098
Query: 486 TDSYE----LVWR-PRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLD 540
T++++ L W P +G + I+ YVV+ R + + W ++ A T+T L
Sbjct: 13099 TETFDGEVSLAWEEPLTDGGSK--IIGYVVERRDIKRKT--WVLATDRAESCEFTVTGLQ 13154
Query: 541 PGSL-YEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPD 599
G + Y ++A N G G+ ++ D+P +
Sbjct: 13155 KGGVEYLFRVSARNRVGTGEP----------------------VETDNPVEA-------- 13184
Query: 600 HGRLSPPEAPDRPTISTASETSVYVTWIP-RGNGGFPIQSFRVEYKKLKKVGDWILATSA 658
+ P P TI+ + V +TW P +GG I ++ +E + + W A +
Sbjct: 13185 RSKYDVPGPPLNVTITDVNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIR-WDTAMT- 13242
Query: 659 IPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYI 718
+ LS +T + +G Y FRVRA N +G +PSA + P+V ERP +
Sbjct: 13243 VRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSA-ATPFV---KVADPIERPSPPVNL 13298
Query: 719 TFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSIS 778
T +D ++++ LKW P + +PI G+ I + D+ + +M + + ++
Sbjct: 13299 TSSDQ-TQSSVQLKW-EPPLKDGGSPILGYII--ERCEEGKDNWIRCNMKLVPELTYKVT 13354
Query: 779 HLQPETSYDIKMQCFNEGGESEFSNVM 805
L+ Y ++ N+ G S+ S ++
Sbjct: 13355 GLEKGNKYLYRVSAENKAGVSDPSEIL 13381
Score = 73.2 bits (178), Expect = 1e-12
Identities = 147/719 (20%), Positives = 251/719 (34%), Gaps = 156/719 (21%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVA---SV 118
P VTWR G + + ++ T LVI G+Y PAG A +V
Sbjct: 18634 PAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNV 18693
Query: 119 PATVTLANLQDFKLDVQHVIEVDEGNTAVIACHL----PESHPKAQVRYSVKQEWLEASR 174
T + D K+ + +CH+ PE+ +QV + + ++ EA R
Sbjct: 18694 RVLDTPGPVSDLKVS----------DVTKTSCHVSWAPPENDGGSQVTHYIVEK-READR 18742
Query: 175 GNYLIMP----SGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAAR 230
+ + + + N +E ++ A N V T L ++ +
Sbjct: 18743 KTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVL----ASDPLSE 18798
Query: 231 IIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNK--------TRFLLS 282
P + + +TK + + + +PP R AK +T Y + T + +
Sbjct: 18799 PDPPRKLEVTEMTKNSATL-----AWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVV 18853
Query: 283 ---NLLIDTTSEEDSGTYRCMADNGVGQ--PGAAVILYNV-QVFEPPEVTMELSQLVIPW 336
+L++ E +R A N VG P A +Y + PP++ M Q+ I
Sbjct: 18854 KDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMP-EQITIKA 18912
Query: 337 GQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL----SRRALRVLSMGPEDEGVYQCM 392
G+ ++ V G P P+ W + +++S L + S L + + +D G Y
Sbjct: 18913 GKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLT 18972
Query: 393 AENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPP 452
AEN G+ +++ ++ P P+PP
Sbjct: 18973 AENSSGTDTQKIKV----------------------------------VVMDAPGPPQPP 18998
Query: 453 TSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKH 512
+ D+ L W E G + I Y+V+
Sbjct: 18999 FDISDID--------------------------ADACSLSWHIPLEDGG-SNITNYIVE- 19030
Query: 513 RKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPK 572
K S DW + + + +L PG Y + A N G +
Sbjct: 19031 -KCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISE------------- 19076
Query: 573 PEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWI-PRGN 631
P SP+ +Q G P P ++ ++ ++V W P +
Sbjct: 19077 ---------------PLTSPKMVAQFPFG---VPSEPKNARVTKVNKDCIFVAWDRPDSD 19118
Query: 632 GGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESE 691
GG PI + +E K+ + W+ A + S GL +G Y FR+ ALN G S
Sbjct: 19119 GGSPIIGYLIERKERNSLL-WVKANDTLVRST-EYPCAGLVEGLEYSFRIYALNKAGSSP 19176
Query: 692 PSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYI 750
PS P+ YV + PV P V ++T+ L W P + + I G+++
Sbjct: 19177 PSKPTE-YVTA-------RMPVDPPGKPEVIDVTKSTVSLIWAR-PKHDGGSKIIGYFV 19226
Score = 73.2 bits (178), Expect = 1e-12
Identities = 161/697 (23%), Positives = 250/697 (35%), Gaps = 166/697 (23%)
Query: 264 WAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPP 323
W KD + T T+F++ +L T E+ + + D GVG+P ++ +V++ E
Sbjct: 20719 WIKDTTG-TALRITQFVVPDL---QTKEKYNFRISAINDAGVGEPA---VIPDVEIVERE 20771
Query: 324 -----EVTMELSQ-LVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALR 377
E+ EL + LV+ G S ++ ++G P P V W ++ + L R +
Sbjct: 20772 MAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINL--KNRANIENTESF 20829
Query: 378 VLSMGPE----DEGVYQCMAENEVGSAHAVVQLR---TSRPSITPR----------LWQD 420
L + PE D G + EN G V +R T P + R L D
Sbjct: 20830 TLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWD 20889
Query: 421 AELATGTPPVSPSKLGNPEQMLRGQPALP----RPPTSVGPASPQCP--------GEKGQ 468
L G ++ + E + + V S C E G
Sbjct: 20890 LPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGI 20949
Query: 469 GAPAEAPI-ILSSPRTSKTDSYE----------LVW-RPRHEGSGRAPILYYVVKHRKVT 516
G P E + +S S DS L W +P+H+G + I YV++ ++
Sbjct: 20950 GEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSK--ITGYVIEAQR-- 21005
Query: 517 NSSDDWT----ISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGE--------------- 557
SD WT + G+ LT G Y ++ A N AG
Sbjct: 21006 KGSDQWTHITTVKGLECVVRNLT-----EGEEYTFQVMAVNSAGRSAPRESRPVIVKEQT 21060
Query: 558 -------------------GQTAMVTFRTGRRPKPEIMASKEQQIQ-------------- 584
G V RPKP + K QI
Sbjct: 21061 MLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATS 21120
Query: 585 ---------RDDPGASPQSSSQ-----------PDHGRLSPPEAPDRPTISTASETSVYV 624
R D G P ++ H PP P + S V
Sbjct: 21121 TILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIK--FDEVSSDFVTF 21178
Query: 625 TWIPRGN-GGFPIQSFRVEYKKLKKVGDWI-LATSAIPPSRLSVEITGLEKGTSYKFRVR 682
+W P N GG PI ++ VE ++ W+ LAT+ I R + + T L G Y+FRV+
Sbjct: 21179 SWDPPENDGGVPISNYVVEMRQTDST-TWVELATTVI---RTTYKATRLTTGLEYQFRVK 21234
Query: 683 ALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNN 742
A N G P S +V+ Y +V P P +T AV + ++ + W + P S+
Sbjct: 21235 AQNRYGVG-PGITS-ACIVANYPFKV-PGPPGTPQVT---AVTKDSMTISW-HEPLSDGG 21287
Query: 743 TPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFS 802
+PI G+++ + + K +V G+ + S L +Y+ ++ N G+S
Sbjct: 21288 SPILGYHVERKERNGILWQTVSKALVPGNIF--KSSGLTDGIAYEFRVIAENMAGKS--- 21342
Query: 803 NVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIER 839
K K S L P + PP P+P I R
Sbjct: 21343 -------KPSKPSEPMLALDP--IDPPGKPVPLNITR 21370
Score = 72.8 bits (177), Expect = 2e-12
Identities = 123/575 (21%), Positives = 214/575 (37%), Gaps = 144/575 (25%)
Query: 264 WAKD----GSSVTGY---------------NKTRFLLSNLLIDTTSEEDSGTYRCMADNG 304
W+K G+ +TGY N T + + +E+ +R A N
Sbjct: 25705 WSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNA 25764
Query: 305 ---VGQPGAAV--ILYNVQVFEPPEVTMELS---QLVIPWGQSAKLTCEVRGNPPPSVLW 356
V +P + I+ V EPP V M++ +V+ G+ K+ ++ G P P + W
Sbjct: 25765 ADSVSEPSESTGPIIVKDDV-EPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISW 25823
Query: 357 LRNAVPLISSQRLRL----SRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPS 412
++ + + R + + L V D G Y +N G+ V +
Sbjct: 25824 AKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKV---- 25879
Query: 413 ITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPA 472
L PP P ++ G + +C
Sbjct: 25880 ----------LDKPGPPAGPLEIN-------------------GLTAEKC---------- 25900
Query: 473 EAPIILSSPRTSKTDSYELVW-RPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQ 531
L W RP+ +G A I YY+V+ R+ ++ + WTI
Sbjct: 25901 -----------------SLSWGRPQEDGG--ADIDYYIVEKRETSHLA--WTICEGELQM 25939
Query: 532 HRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGAS 591
+T+L G+ Y + N G G+ + I+ DP
Sbjct: 25940 TSCKVTKLLKGNEYIFRVTGVNKYGVGEPL-----------------ESVAIKALDPFTV 25982
Query: 592 PQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKVG 650
P SPP + + I++ ++ S+ + W P +GG I + +E ++ +
Sbjct: 25983 P-----------SPPTSLE---ITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLR 26028
Query: 651 DWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYE 710
W+ P L V+ TGL +G Y++RV A N G S PS S ++
Sbjct: 26029 -WVRVNKK-PVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSP--LIRAEDPVFLP 26084
Query: 711 RPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDM--V 768
P + P I + +TTI + W+ P + PI G+ + Y+ +D D+D+K + +
Sbjct: 26085 SPPSKPKIVDS---GKTTITIAWVK-PLFDGGAPITGYTVEYKKSD---DTDWKTSIQSL 26137
Query: 769 EGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSN 803
G +Y +IS L Y +++ N+ G S+ S+
Sbjct: 26138 RGTEY--TISGLTTGAEYVFRVKSVNKVGASDPSD 26170
Score = 72.4 bits (176), Expect = 2e-12
Identities = 78/329 (23%), Positives = 132/329 (40%), Gaps = 51/329 (15%)
Query: 475 PIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRL 534
P+ +S+ K L W P E G +PI Y+++ R+ + WT+ R
Sbjct: 20478 PVEISNVSAEKAT---LTWTPPLEDGG-SPIKSYILEKRETSRLL--WTVVSEDIQSCRH 20531
Query: 535 TLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQS 594
T+L G+ Y ++A N G+G+ QS
Sbjct: 20532 VATKLIQGNEYIFRVSAVNHYGKGEPV-------------------------------QS 20560
Query: 595 SSQPDHGRLSPPEAPDRPTISTASETSVYVTW-IPRGNGGFPIQSFRVEYKKLKKVGDWI 653
R PP P++P +S ++ + V+W P +GG I + VE ++ KK W+
Sbjct: 20561 EPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVE-RREKKSLRWV 20619
Query: 654 LATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPV 713
A P S L ++TGL++G++Y+FRV A N G PS S ++ P
Sbjct: 20620 RAIKT-PVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMK--DAAYPPGPP 20676
Query: 714 AGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDK- 772
+ P++T T + + L W P + I G+ + ++ D + KD
Sbjct: 20677 SNPHVTDT---TKKSASLAWGK-PHYDGGLEITGYVVEHQKV---GDEAWIKDTTGTALR 20729
Query: 773 -YWHSISHLQPETSYDIKMQCFNEGGESE 800
+ LQ + Y+ ++ N+ G E
Sbjct: 20730 ITQFVVPDLQTKEKYNFRISAINDAGVGE 20758
Score = 72.0 bits (175), Expect = 3e-12
Identities = 60/241 (24%), Positives = 101/241 (41%), Gaps = 22/241 (9%)
Query: 182 SGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTII 241
S +L++ N ED Y C N + S L V+ E + P Q I
Sbjct: 5291 SVSLEVNNLELEDTANYTCKVSNVAGDDA----CSGILTVK----EPPSFLVKPGRQQAI 5342
Query: 242 VTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLL----SNLLIDTTSEEDSGTY 297
++ + + G PP ++ W KD + K L S L + + +G Y
Sbjct: 5343 --PDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQY 5400
Query: 298 RCMADNGVGQPGAAVILYNVQVFEPPEVTMEL-SQLVIPWGQSAKLTCEVRGNPPPSVLW 356
C N VG +L V EPP+ +L + ++ G S++L C++ G+P V+W
Sbjct: 5401 TCHVTNDVGSDSCTTMLL---VTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVW 5457
Query: 357 LRNAVPLISSQRLRL----SRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPS 412
RN L +S + R+ S +++ ++ ED G + C A+N GS ++ P
Sbjct: 5458 FRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPP 5517
Query: 413 I 413
+
Sbjct: 5518 V 5518
Score = 72.0 bits (175), Expect = 3e-12
Identities = 80/362 (22%), Positives = 145/362 (40%), Gaps = 23/362 (6%)
Query: 62 PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNN--HTVGRYQCVARMPAGAVASVP 119
P ++V+W + + L + + +T + ++ L + +Y C+ AG
Sbjct: 6954 PPISVSW-IKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDIC-E 7011
Query: 120 ATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLI 179
A V++ F ++HV E G A + C + + P+ ++ + + L ++ +
Sbjct: 7012 ALVSVLEPPYFIEPLEHV-EAVIGEPATLQCKV-DGTPEIRISWYKEHTKLRSAPAYKMQ 7069
Query: 180 MPSG--NLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEA 237
+ +L I D G Y C A N V S + ++ R+ AR +
Sbjct: 7070 FKNNVASLVINKVDHSDVGEYSCKADNSVG--AVASSAVLVIKARKLPPFFAR-----KL 7122
Query: 238 QTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVT--GYNKTRFL--LSNLLIDTTSEED 293
+ + T G + EC +G P +V+W KDG + +T F+ ++ L I T +
Sbjct: 7123 KDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSH 7182
Query: 294 SGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPS 353
G Y C A N +G ++ L + PP ++ + + G+S C V G P
Sbjct: 7183 IGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIK 7242
Query: 354 VLWLRNAVPLISSQRLRL----SRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTS 409
+ W ++ + ++ + L VL +G D G Y C A N G QL
Sbjct: 7243 ITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQ 7302
Query: 410 RP 411
P
Sbjct: 7303 EP 7304
Score = 71.6 bits (174), Expect = 4e-12
Identities = 75/322 (23%), Positives = 132/322 (40%), Gaps = 48/322 (14%)
Query: 486 TDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLY 545
+D L W P E G + I Y+V R+ + + + +P ++ +L G Y
Sbjct: 19402 SDRAMLSWEPPLEDGG-SEITNYIVDKRETSRPNWAQVSATVPITS--CSVEKLIEGHEY 19458
Query: 546 EVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSP 605
+ + A N G G + P P
Sbjct: 19459 QFRICAENKYGVGDPVFTEPAIAKNP-------------------------------YDP 19487
Query: 606 PEAPDRPTISTASETSVYVTWIPRGN-GGFPIQSFRVEYKKLKKVGDWILATSAIPPSRL 664
P D P IS ++ + V+W P + GG PI + +E ++ + V +W P
Sbjct: 19488 PGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAV-NWTKVNRK-PIIER 19545
Query: 665 SVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAV 724
+++ TGL++GT Y+FRV A+N G +PS S+ + Y+ R + P P
Sbjct: 19546 TLKATGLQEGTEYEFRVTAINKAGPGKPSDASK----AAYA-RDPQYPPGPPAFPKVYDT 19600
Query: 725 NETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDN--DSDYKKDMVEGDKYWHSISHLQP 782
+++ L W PA + +PI G+ + + DSDN + +++ K ++ L
Sbjct: 19601 TRSSVSLSWGK-PAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNL---QKTRFEVTGLME 19656
Query: 783 ETSYDIKMQCFNEGGESEFSNV 804
+T Y ++ N+ G S+ S+V
Sbjct: 19657 DTQYQFRVYAVNKIGYSDPSDV 19678
Score = 71.6 bits (174), Expect = 4e-12
Identities = 67/249 (26%), Positives = 106/249 (42%), Gaps = 51/249 (20%)
Query: 467 GQGAPAEA-------PIILSSPRTS------KTDSYELVWRPRHEGSGRAPILYYVVKHR 513
G G P E+ P + SP TS +S L W R E G + I Y+++ R
Sbjct: 25964 GVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWS-RPESDGGSEISGYIIERR 26022
Query: 514 KVTNSSDDWT-ISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPK 572
+ +S W ++ P R+ T L G YE + A N AG
Sbjct: 26023 E--KNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLS-------------- 26066
Query: 573 PEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWI-PRGN 631
+ + I+ +DP + P P +P I + +T++ + W+ P +
Sbjct: 26067 --LPSETSPLIRAEDP--------------VFLPSPPSKPKIVDSGKTTITIAWVKPLFD 26110
Query: 632 GGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESE 691
GG PI + VEYKK DW + ++ + + I+GL G Y FRV+++N +G S+
Sbjct: 26111 GGAPITGYTVEYKKSDDT-DWKTSIQSLRGTEYT--ISGLTTGAEYVFRVKSVNKVGASD 26167
Query: 692 PSAPSRPYV 700
PS S P +
Sbjct: 26168 PSDSSDPQI 26176
Score = 70.9 bits (172), Expect = 7e-12
Identities = 113/468 (24%), Positives = 169/468 (36%), Gaps = 115/468 (24%)
Query: 451 PPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDS--YELVWRPRHEGSGRAPILYY 508
P T+ P SP P PI PR + T S EL W P G + Y+
Sbjct: 14993 PKTAHDPISPPGP-----------PI----PRVTDTSSTTIELEWEPPAFNGGGEIVGYF 15037
Query: 509 VVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEG---QTAMVTF 565
V K TN T I Q+ T+ + G+ Y++ ++A N AGEG +T VT
Sbjct: 15038 VDKQLVGTNEWSRCTEKMIKVRQY--TVKEIREGADYKLRVSAVNAAGEGPPGETQPVTV 15095
Query: 566 RTGRRPKP-----------EIMASKEQQIQR--------------------------DDP 588
+ P +IMA K +I D+
Sbjct: 15096 AEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNV 15155
Query: 589 GASPQ----SSSQPDHGRLSPPEAPDRPTISTASETSVY--------------------V 624
G + + + DHGR + A+ V+ +
Sbjct: 15156 GTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPGPVLDLKPVVTNRKMCLL 15215
Query: 625 TWI-PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRA 683
W P +GG I F +E +K K+ W I R +ITGL +G YKFRV A
Sbjct: 15216 NWSDPEDDGGSEITGFIIE-RKDAKMHTW---RQPIETERSKCDITGLLEGQEYKFRVIA 15271
Query: 684 LNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNT 743
N G P P + G P + +T+T+ ++TI L W P SN +
Sbjct: 15272 KNKFG-CGPPVEIGPILAVDPLG----PPTSPERLTYTER-TKSTITLDWKE-PRSNGGS 15324
Query: 744 PIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFS- 802
PI G+ I R D + K + + + +L Y+ +++ NE GESE S
Sbjct: 15325 PIQGYIIEKRRHDKPDFERVNKRLCPTTSF--LVENLDEHQMYEFRVKAVNEIGESEPSL 15382
Query: 803 --NVMICETKA---------------RKSSGQPGRLPPPTLAPPQPPL 833
NV+I + + + +G+P +P P P +
Sbjct: 15383 PLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKI 15430
Score = 70.9 bits (172), Expect = 7e-12
Identities = 77/324 (23%), Positives = 124/324 (38%), Gaps = 45/324 (13%)
Query: 483 TSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPG 542
T+ T +W G API +Y+++ R+ + + W + T +L G
Sbjct: 28062 TNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSRLA--WALIEDKCEAQSYTAIKLING 28119
Query: 543 SLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGR 602
+ Y+ ++A N G G +P QIQ
Sbjct: 28120 NEYQFRVSAVNKFGVG-------------RPLDSDPVVAQIQ------------------ 28148
Query: 603 LSPPEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPP 661
+ P+AP P S + S+ +TW P +GG IQ + +E ++ KK W+ S P
Sbjct: 28149 YTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILE-RREKKSTRWVKVISKRPI 28207
Query: 662 SRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFT 721
S ++TGL +G Y+F V A N G S SR R P P +
Sbjct: 28208 SETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRL-----IKCREPVNPPGPPTVVKV 28262
Query: 722 DAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEG-DKYWHSISHL 780
++TT+ L+W P + I G+ I D D+ K E K ++++ L
Sbjct: 28263 TDTSKTTVSLEWSK-PVFDGGMEIIGYIIEMCKADL---GDWHKVNAEACVKTRYTVTDL 28318
Query: 781 QPETSYDIKMQCFNEGGESEFSNV 804
Q Y ++ N G+ + V
Sbjct: 28319 QAGEEYKFRVSAINGAGKGDSCEV 28342
Score = 70.5 bits (171), Expect = 9e-12
Identities = 162/744 (21%), Positives = 267/744 (35%), Gaps = 173/744 (23%)
Query: 140 VDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYK 199
V +G +I ++ E PK S + W + L+ + ++ +QE E ++
Sbjct: 18521 VYDGGAPIIG-YVVEMRPKI-ADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYE--FR 18576
Query: 200 CAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEA-------QTIIVTKGQSLILEC 252
A N V R + + I+ PPE + +IV G + L
Sbjct: 18577 VCAQNQV--------GIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRLFA 18628
Query: 253 VASGIPPPRVTWAKDG-SSVTGYNKTRFL--LSNLLIDTTSEEDSGTYRCMADNGVGQPG 309
+ G P P+VTW K G +V + + ++ L+I ++ +DSG Y N G+
Sbjct: 18629 IVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGE-- 18686
Query: 310 AAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRL 369
+ NV+V + P +L K +C V PP
Sbjct: 18687 -KAVFVNVRVLDTPGPVSDLKV-----SDVTKTSCHVSWAPP------------------ 18722
Query: 370 RLSRRALRVLSMGPEDEGVYQCMAENEVGS--AHAVVQLRTSRPSITPRLWQDAELATGT 427
EN+ GS H +V+ R + + W +T T
Sbjct: 18723 ------------------------ENDGGSQVTHYIVEKREA----DRKTW-----STVT 18749
Query: 428 PPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPR----- 482
P V + + ++ G R T+V P P + + A P+ P
Sbjct: 18750 PEVKKTSF-HVTNLVPGNEYYFR-VTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEV 18807
Query: 483 TSKT-DSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDP 541
T T +S L W P G A I Y+ +R+ +D WT + L +T L
Sbjct: 18808 TEMTKNSATLAWLPPLRDGG-AKIDGYITSYREEEQPADRWTEYSV-VKDLSLVVTGLKE 18865
Query: 542 GSLYEVEMAAYNCAG-------EG--------------QTAMVTFRTGR----------R 570
G Y+ +AA N G EG +T + G+ +
Sbjct: 18866 GKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGK 18925
Query: 571 PKP---------EIMASKE--------------QQIQRDDPG---ASPQSSSQPDHGRL- 603
P P E++ S + + R D G + ++SS D ++
Sbjct: 18926 PHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIK 18985
Query: 604 -------SPPEAPDRPTISTASETSVYVTW-IPRGNGGFPIQSFRVEYKKLKKVGDWILA 655
PP+ P IS + ++W IP +GG I ++ VE + + GDW+ A
Sbjct: 18986 VVVMDAPGPPQPPF--DISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSR-GDWVTA 19042
Query: 656 TSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAG 715
+++ ++ S + L G Y FRVRA N G SEP + P +V+ + V P
Sbjct: 19043 LASV--TKTSCRVGKLIPGQEYIFRVRAENRFGISEPL--TSPKMVAQFPFGVPSEPKNA 19098
Query: 716 PYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWH 775
VN+ I + W P S+ +PI G+ I + +S +V +Y
Sbjct: 19099 R----VTKVNKDCIFVAWDR-PDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEY-- 19151
Query: 776 SISHLQPETSYDIKMQCFNEGGES 799
+ L Y ++ N+ G S
Sbjct: 19152 PCAGLVEGLEYSFRIYALNKAGSS 19175
Score = 70.5 bits (171), Expect = 9e-12
Identities = 116/537 (21%), Positives = 188/537 (35%), Gaps = 121/537 (22%)
Query: 285 LIDTTSEEDSGTYRCMADNGVGQPGAA----VILYNVQVFEPPEVTMELSQLVIPW-GQS 339
++ +E + T++ MA N G+ VI+ + ++ +LVI G +
Sbjct: 21023 VVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDN 21082
Query: 340 AKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRA----LRVLSMGPEDEGVYQCMAEN 395
K+ V G P P+V W + L +QR+ A L + D G Y A N
Sbjct: 21083 IKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARN 21142
Query: 396 EVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSV 455
VG V+ ++ +P PPT
Sbjct: 21143 IVGEVGDVITIQVHD-------------------------------------IPGPPTG- 21164
Query: 456 GPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKV 515
PI +D W P E G PI YVV+ R+
Sbjct: 21165 -------------------PIKFDEV---SSDFVTFSWDPP-ENDGGVPISNYVVEMRQT 21201
Query: 516 TNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEI 575
+++ W + TRL G Y+ + A N G G
Sbjct: 21202 DSTT--WVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVG----------------- 21242
Query: 576 MASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWI-PRGNGGF 634
PG + S+ + P P P ++ ++ S+ ++W P +GG
Sbjct: 21243 ------------PGIT--SACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHEPLSDGGS 21288
Query: 635 PIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSA 694
PI + VE K+ + W + A+ P + + +GL G +Y+FRV A NM G+S+PS
Sbjct: 21289 PILGYHVERKERNGIL-WQTVSKALVPGNI-FKSSGLTDGIAYEFRVIAENMAGKSKPSK 21346
Query: 695 PSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRP 754
PS P + P+ P + T+ LKW P I + + R
Sbjct: 21347 PSEPMLALD--------PIDPPGKPVPLNITRHTVTLKWAK-PEYTGGFKITSYIVEKR- 21396
Query: 755 TDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGG----ESEFSNVMIC 807
D N K + + ++S L + +Y+ ++ N G SE S+ + C
Sbjct: 21397 -DLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITC 21452
Score = 70.5 bits (171), Expect = 9e-12
Identities = 111/495 (22%), Positives = 181/495 (36%), Gaps = 95/495 (19%)
Query: 260 PRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVG-----QPGAAVIL 314
P W K +S T T F ++ L+ D E +R +A N G I
Sbjct: 22481 PEGRWMK--ASFTNIIDTHFEVTGLVEDHRYE-----FRVIARNAAGVFSEPSESTGAIT 22533
Query: 315 YNVQVFEPPEVTME---LSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL 371
+V +PP ++M+ +V+ G+S K+ ++ G P P++ W++ L ++ RL +
Sbjct: 22534 ARDEV-DPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEI 22592
Query: 372 SRR----ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRT-------SRPSITPRLWQD 420
+L V D G Y A+N G V ++ P + + +
Sbjct: 22593 KSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAE 22652
Query: 421 AELATGTPPVSP--SKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEK------------ 466
PP+ S + N R L + C K
Sbjct: 22653 KCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIM 22712
Query: 467 -----GQGAPAEA-PIILSSP------------RTSKTDSYELVWRPRHEGSGRAPILYY 508
G G P E+ P++ +P T DS +VW R G + IL Y
Sbjct: 22713 AVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWE-RPASDGGSEILGY 22771
Query: 509 VVKHRKVTNSSDDWT-ISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRT 567
V++ R WT + RL +T L YE ++A N AG +
Sbjct: 22772 VLEKRD--KEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEP------- 22822
Query: 568 GRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWI 627
SP S+ Q + P P+ P + + +SV+++W
Sbjct: 22823 -----------------------SPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFLSWS 22859
Query: 628 -PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNM 686
P +GG IQ + VE K VG+W + T ++ ++E+ L + Y FR+ A+N
Sbjct: 22860 KPIYDGGCEIQGYIVE-KCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAINK 22918
Query: 687 LGESEPSAPSRPYVV 701
G E + P +V
Sbjct: 22919 AGVGEHADVPGPIIV 22933
Score = 70.1 bits (170), Expect = 1e-11
Identities = 87/356 (24%), Positives = 140/356 (39%), Gaps = 62/356 (17%)
Query: 467 GQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISG 526
G+ P PI S D L W P + G + I YV++ R+ + W
Sbjct: 16215 GRPGPPVGPIKFESV---SADQMTLSWFPPKDDGG-SKITNYVIEKREANRKT--WVHVS 16268
Query: 527 IPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRD 586
+ T+ +L G Y + A N G G+
Sbjct: 16269 SEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPL------------------------- 16303
Query: 587 DPGASPQSSSQPDHGR--LSPPEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEY 643
S+P+ R S P APD+PT+S+ + S+ V W P +GG P+ + +E
Sbjct: 16304 --------DSEPETARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEM 16355
Query: 644 K-----KLKKVG-DWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSR 697
K + K+V D I A + +S ++TGL +G+ Y+FRV A+N G S PS
Sbjct: 16356 KDTTSKRWKRVNRDPIKAMTL----GVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSD 16411
Query: 698 PYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDS 757
P + R P P+ TD +++ L+W P + + + G+ + Y+
Sbjct: 16412 P-----ATARDPIAPPGPPFPKVTD-WTKSSADLEWS-PPLKDGGSKVTGYIVEYKEEGK 16464
Query: 758 DNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVM-ICETKAR 812
+ K V G K ++ L+ Y +++ N G E V + E K R
Sbjct: 16465 EEWEKGKDKEVRGTKL--VVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKDR 16518
Score = 70.1 bits (170), Expect = 1e-11
Identities = 148/675 (21%), Positives = 254/675 (37%), Gaps = 159/675 (23%)
Query: 272 TGYNKTRFLLSNLLIDTTSEEDSGTYRCMADN--GVGQ----PGAAVILYNVQVFEPPEV 325
TG NKT + LL E+ +R A N GVG+ PG ++ + E P++
Sbjct: 22891 TGINKTNIEVEKLL-----EKHEYNFRICAINKAGVGEHADVPGPIIV---EEKLEAPDI 22942
Query: 326 TMELSQ---LVIPWGQSAKLTCEVRGNPPPSVLW------LRNAVPLISSQRLRLSRRAL 376
++L + I G S +L ++G P P V W +R+A + + S +L
Sbjct: 22943 DLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTS----SFTSL 22998
Query: 377 RVLSMGPEDEGVYQCMAENEVGSAHAVVQLR---TSRPSITPRLWQ---DAELATGTPPV 430
+ ++ D G Y EN G+ A V +R T P + ++ + D+ T PP+
Sbjct: 22999 VLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPL 23058
Query: 431 --SPSKLGN-----PEQMLRGQPALP----RPPTSVGPASPQCP--------GEKGQGAP 471
SK+ N E + A+ + + C E G G P
Sbjct: 23059 LDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLP 23118
Query: 472 AEA--PIILSS----PRTSKTD-----SYELVW-RPRHEGSGRAPILYYVVKHRKVTNSS 519
A+ PI ++ P D S L W +P H+G + I+ Y+V+ + S
Sbjct: 23119 AQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSK--IIQYIVEMQ--AKHS 23174
Query: 520 DDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGE---------------------- 557
+ W+ + +T L G Y + A N G
Sbjct: 23175 EKWSECA-RVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVK 23233
Query: 558 ----------GQTAMVTFRTGRRPKPEIMASKE-----------------------QQIQ 584
GQ + RPKP I +K+ ++
Sbjct: 23234 PAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETH 23293
Query: 585 RDDPG--------ASPQSSSQPDHGRLSPPEAPDRPT-ISTASETSVYVTWIPR-GNGGF 634
+DD G Q ++ + L P+ P P S S+ ++W P GG
Sbjct: 23294 KDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGC 23353
Query: 635 PIQSFRVEYKKLKK-VGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLG----- 688
I ++ V+ + V D + AT A R ++++T L+ GT Y+FR+ A N G
Sbjct: 23354 QITNYIVQKRDTTTTVWDVVSATVA----RTTLKVTKLKTGTEYQFRIFAENRYGQSFAL 23409
Query: 689 ESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGF 748
ES+P PY G P P+ T A+++ +++++W + P +N +P+ G+
Sbjct: 23410 ESDPIVAQYPYKEPG--------PPGTPFAT---AISKDSMVIQW-HEPVNNGGSPVIGY 23457
Query: 749 YIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICE 808
++ + +S + K ++ ++ +L+ Y+ ++ N G + S C
Sbjct: 23458 HLERKERNSILWTKVNKTIIHDTQF--KAQNLEEGIEYEFRVYAENIVGVGKASKNSECY 23515
Query: 809 TKARKSSGQPGRLPP 823
AR PG P
Sbjct: 23516 V-ARDPCDPPGTPEP 23529
Score = 70.1 bits (170), Expect = 1e-11
Identities = 115/557 (20%), Positives = 208/557 (37%), Gaps = 130/557 (23%)
Query: 260 PRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQ---------PGA 310
P W K +S T +T+F++S L ++ E +R A N VG P
Sbjct: 26810 PDGRWTK--ASFTNVTETQFIISGLTQNSQYE-----FRVFARNAVGSISNPSEVVGPIT 26862
Query: 311 AVILYNVQVFEPPEVTMELSQLV-IPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRL 369
+ Y V + P +E +++V G S KL + G P P++ W ++ L ++ +
Sbjct: 26863 CIDSYGGPVIDLP---LEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALV 26919
Query: 370 RLSRR----ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELAT 425
+ ++ + + G Y+ N +GSA A +++
Sbjct: 26920 CVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRV------------------- 26960
Query: 426 GTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSK 485
Q+L P PP G P E +T
Sbjct: 26961 --------------QILDK----PGPP----------------GGPIEF-------KTVT 26979
Query: 486 TDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLY 545
+ L+WRP + G A I +Y+V+ R+ + W++ + +T T++ G+ Y
Sbjct: 26980 AEKITLLWRPPADDGG-AKITHYIVEKRETSRVV--WSMVSEHLEECIITTTKIIKGNEY 27036
Query: 546 EVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSP 605
+ A N G G+ +S S
Sbjct: 27037 IFRVRAVNKYGIGEPL-------------------------------ESDSVVAKNAFVT 27065
Query: 606 PEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRL 664
P P P ++ ++ S+ V W P +GG I + +E + K +G + + I +R
Sbjct: 27066 PGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQ 27125
Query: 665 SVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAV 724
V TGL + + Y++RV A+N G+ S PS Y + + P I D+
Sbjct: 27126 KV--TGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAAD----PIDPPGPPAKIRIADS- 27178
Query: 725 NETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYK-KDMVEGDKYWHSISHLQPE 783
+++I L W P + + + G+ + R + + + K V +Y +S+L+P
Sbjct: 27179 TKSSITLGWSK-PVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEY--VVSNLKPG 27235
Query: 784 TSYDIKMQCFNEGGESE 800
+Y ++ N G+ E
Sbjct: 27236 VNYYFRVSAVNCAGQGE 27252
Score = 70.1 bits (170), Expect = 1e-11
Identities = 57/203 (28%), Positives = 95/203 (46%), Gaps = 15/203 (7%)
Query: 607 EAPDRPT----ISTASETSVYVTWIPRGN-GGFPIQSFRVEYKKLKKVGDWILATSAIPP 661
+ PD+PT I + S ++W P + GG I ++ VE + K+ +W L +SAI
Sbjct: 30721 DKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAI-- 30778
Query: 662 SRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFT 721
S + I L + Y FRV A N G S+P S ++ +E+P A T T
Sbjct: 30779 SVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKS----PFEKPGAPGKPTIT 30834
Query: 722 DAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQ 781
AV + + ++ W PAS+ I +Y+ R + + + + S+ +L
Sbjct: 30835 -AVTKDSCVVAWKP-PASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVF--SVKNLI 30890
Query: 782 PETSYDIKMQCFNEGGESEFSNV 804
Y+ +++C N GGESE+S +
Sbjct: 30891 EGLEYEFRVKCENLGGESEWSEI 30913
Score = 69.3 bits (168), Expect = 2e-11
Identities = 95/405 (23%), Positives = 156/405 (38%), Gaps = 47/405 (11%)
Query: 57 CVVEPPRMNVTWRLNGKELNGSD--DALGVLITHGTLVITALNNHTVGRYQCVARMPAGA 114
C V P + V W + +EL +D H L+I + G+Y VA
Sbjct: 3079 CEVSEPDITVQWMKDDQELQITDRIKIQKEKYVH-RLLIPSTRMSDAGKYTVVAG----- 3132
Query: 115 VASVPATVTLANLQDFKL-DVQHVIEVDEGNTAVIACHLPESHPKAQ-VRYSVKQEWLEA 172
+V +D ++ ++ ++V E AV+ + E A + ++ +
Sbjct: 3133 -GNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQ 3191
Query: 173 SRGNYLIMPSGNLQIVNAS-QEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARI 231
R Y++ + ++ + Q D G Y A + SS L V + E ++
Sbjct: 3192 ERHKYVVERRIHRMFISETRQSDAGEYTFVAGR--------NRSSVTLYV--NAPEPPQV 3241
Query: 232 IYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN----LLID 287
+ E Q + V G+ V SG P P+++W K+ ++ K +FL LL+
Sbjct: 3242 LQ--ELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLI 3299
Query: 288 TTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFE-----------PPEVTMELSQLVIPW 336
ED+ Y C A N G + L +V+V E PP + L V
Sbjct: 3300 EAFPEDAAVYTCEAKNDYGVATTSASL-SVEVPEVVSPDQEMPVYPPAIITPLQDTVTSE 3358
Query: 337 GQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSR----RALRVLSMGPEDEGVYQCM 392
GQ A+ C V G V W + S+ R+++ L + PEDEG Y +
Sbjct: 3359 GQPARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFV 3417
Query: 393 AENEVGSAHAVVQLRTSRPS--ITPRLWQDAELATGTPPVSPSKL 435
A N VG + L P + R+ Q+ E+ PV K+
Sbjct: 3418 ASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKI 3462
Score = 69.3 bits (168), Expect = 2e-11
Identities = 78/334 (23%), Positives = 135/334 (40%), Gaps = 52/334 (15%)
Query: 467 GQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISG 526
G+ P PI +SS +S L W +G G I Y+V+ R+ + + W +
Sbjct: 28739 GRPGPVTGPIEVSSV---SAESCVLSWGEPKDGGG-TEITNYIVEKRE--SGTTAWQLVN 28792
Query: 527 IPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRD 586
+ ++ +T L Y +++ N G SK +
Sbjct: 28793 SSVKRTQIKVTHLTKYMEYSFRVSSENRFG--------------------VSKPLE---- 28828
Query: 587 DPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKK 645
++P + P PP AP RP + S ++ + W P +GG I + VE KK
Sbjct: 28829 ---SAPIIAEHP----FVPPSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVE-KK 28880
Query: 646 LKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYS 705
+ W+ + +P + ++TGL +G Y+FR ALN G S+ S SRP +
Sbjct: 28881 ERNTILWV-KENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMA---- 28935
Query: 706 GRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKK 765
+ PV P V +T+ L W PA + + + G+ I +P D + K
Sbjct: 28936 ----QNPVDAPGRPEVTDVTRSTVSLIWS-APAYDGGSKVVGYIIERKPVSEVGDGRWLK 28990
Query: 766 --DMVEGDKYWHSISHLQPETSYDIKMQCFNEGG 797
+ D ++ +++ L +Y+ ++ N G
Sbjct: 28991 CNYTIVSDNFF-TVTALSEGDTYEFRVLAKNAAG 29023
Score = 68.6 bits (166), Expect = 3e-11
Identities = 63/250 (25%), Positives = 98/250 (39%), Gaps = 36/250 (14%)
Query: 594 SSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWI 653
S S R P+APD+P ++ ++ S VTW +GG PI ++ +E K+ W
Sbjct: 17000 SDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKPITNYILE-KRETMSKRWA 17058
Query: 654 LATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPV 713
T + L +G Y+FRV A N +G +PS PS+P + P+
Sbjct: 17059 RVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFA--------KDPI 17110
Query: 714 AGPYITFTDAVNETT---IMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEG 770
A P +TT + L W P + + I G+ + Y+ G
Sbjct: 17111 AKPSPPVNPEAIDTTCNSVDLTWQ-PPRHDGGSKILGYIVEYQKV--------------G 17155
Query: 771 DKYWHSISHLQ---PETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLA 827
D+ W +H PET Y K+ +G +F + + P +P P L
Sbjct: 17156 DEEWRRANHTPESCPETKY--KVTGLRDGQTYKFRVLAV----NAAGESDPAHVPEPVLV 17209
Query: 828 PPQPPLPETI 837
+ PE I
Sbjct: 17210 KDRLEPPELI 17219
Score = 68.6 bits (166), Expect = 3e-11
Identities = 136/662 (20%), Positives = 242/662 (36%), Gaps = 139/662 (20%)
Query: 272 TGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQV---FEPPEVTME 328
TG TRF +S L +E R A N VG A + V+ E PE+ ++
Sbjct: 23973 TGLRVTRFEISKL-----TEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLD 24027
Query: 329 LSQ---LVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLR--LSRRALRVLSMGP 383
+V+ G SA++ +G P P + W R ++ ++ L + +
Sbjct: 24028 SELRKGIVVRAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDR 24087
Query: 384 EDEGVYQCMAENEVGSAHAVVQLRTSRPSITPR------LWQDAELATGTPPVSPSKLGN 437
D G Y EN GS A V ++ P+ + +D+ PP+
Sbjct: 24088 NDAGKYILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKV 24147
Query: 438 PEQMLRGQPALPRPPTSVGPASPQ-------------------CPGEKGQGAPAEAPIIL 478
++ + + + +V + E G G P E +
Sbjct: 24148 KNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAV 24207
Query: 479 SSP-------RTSKTD----SYELVW-RPRHEGSGRAPILYYVVKHRKVTNSSDDWTISG 526
+ + + TD S L+W +P H+G R +L YVV+ + ++ W+I
Sbjct: 24208 KAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSR--VLGYVVEMQP--KGTEKWSIVA 24263
Query: 527 IPANQHRLTLTRLDPGSLYEVEMAAYNCAGE----------------------------- 557
+ +T L G Y+ + AYN G+
Sbjct: 24264 -ESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYS 24322
Query: 558 ---GQTAMVTFRTGRRPKPEIMASKEQQ-------IQRDDPGASP----QSSSQPDHGRL 603
G+ + RP+P I K+ + + ++ S + ++ D G+
Sbjct: 24323 IQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKY 24382
Query: 604 S-----------------------PPEAPDRPTISTASETSVYVTWIPRG-NGGFPIQSF 639
+ PP P R S V ++W P GG I ++
Sbjct: 24383 TVTATNSAGTATENLSVIVLEKPGPPVGPVR--FDEVSADFVVISWEPPAYTGGCQISNY 24440
Query: 640 RVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPY 699
VE K+ W + ++ + +R +++IT L+ GT Y+FR+ A N G+S P S+
Sbjct: 24441 IVE-KRDTTTTTWHMVSATV--ARTTIKITKLKTGTEYQFRIFAENRYGKSAP-LDSKAV 24496
Query: 700 VVSGYSGRVYERPVAGPYIT-FTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSD 758
+V Y GP T F ++++ ++++W + P ++ T I G+++ + +S
Sbjct: 24497 IVQ------YPFKEPGPPGTPFVTSISKDQMLVQW-HEPVNDGGTKIIGYHLEQKEKNSI 24549
Query: 759 NDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQP 818
K ++ K+ + L Y+ K+ N G + S V C AR P
Sbjct: 24550 LWVKLNKTPIQDTKF--KTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFV-ARDPCDPP 24606
Query: 819 GR 820
GR
Sbjct: 24607 GR 24608
Score = 68.2 bits (165), Expect = 4e-11
Identities = 76/265 (28%), Positives = 114/265 (43%), Gaps = 37/265 (13%)
Query: 589 GASPQSSSQP--DHGRLSPPEAPDRPTISTASETSVYVTWIP-RGNGGFPIQSFRVEYKK 645
G P + S+P + P PD P ++ S+ + V W P +GG I + +E KK
Sbjct: 18377 GTGPPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLE-KK 18435
Query: 646 LKKVGDWI-LATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGY 704
K W+ + SAIP R+ V+ L Y+FRV+A N +G EPS PSRP V
Sbjct: 18436 EKHSTRWVPVNKSAIPERRMKVQ--NLLPDHEYQFRVKAENEIGIGEPSLPSRPVVA--- 18490
Query: 705 SGRVYERPVAGPYITFTDAVNETT---IMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDS 761
+ P+ P V +TT I L W P + PI G+ + RP +D
Sbjct: 18491 -----KDPIEPPGPPTNFRVVDTTKHSITLGWGK-PVYDGGAPIIGYVVEMRPKIADASP 18544
Query: 762 DYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRL 821
D EG K ++ + L + + +E E EF +C + + G+P L
Sbjct: 18545 D------EGWKRCNAAAQL---VRKEFTVTSLDENQEYEF---RVC-AQNQVGIGRPAEL 18591
Query: 822 -----PPPTLAPPQPPLPETIERPV 841
P L PP+ L ++ + V
Sbjct: 18592 KEAIKPKEILEPPEIDLDASMRKLV 18616
Score = 67.8 bits (164), Expect = 6e-11
Identities = 82/413 (19%), Positives = 146/413 (35%), Gaps = 52/413 (12%)
Query: 64 MNVTWRLNGKEL-NGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATV 122
+ V+W + +E+ +G + L L + ++ G+Y C A G +
Sbjct: 8182 IKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLN 8241
Query: 123 TLANL--QDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIM 180
L F + +E EGN+ + + S P Y + N I
Sbjct: 8242 IKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWY----------KNNIEIQ 8291
Query: 181 PSGN-----------LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAA 229
P+ N LQ+ A D G+Y C N + TS + ++
Sbjct: 8292 PTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSS----IVIKEPKKPP- 8346
Query: 230 RIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN----LL 285
++ + V++G+ + L C G P R+ W K G + ++ F ++ L
Sbjct: 8347 --VFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLE 8404
Query: 286 IDTTSEEDSGTYRCMADNGVG------------QPGAAVILYNVQVFEPPEVTMELSQLV 333
+ ++ DSG Y C A N G +P A V E +
Sbjct: 8405 LRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIR 8464
Query: 334 IPWGQSAKLTCEVRGNPPPSVLWLRNAV-PLISSQRLRLSRRA----LRVLSMGPEDEGV 388
+ +A +V G+P P+V W + L R+ + ++ L + D G+
Sbjct: 8465 VVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGL 8524
Query: 389 YQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQM 441
Y+C+A NE G + V L+ ++ D P+ G E++
Sbjct: 8525 YRCVAFNEHGEIESNVNLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEI 8577
Score = 67.8 bits (164), Expect = 6e-11
Identities = 84/364 (23%), Positives = 143/364 (39%), Gaps = 40/364 (10%)
Query: 62 PRMNVTWRLNGKELNG------SDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAV 115
PR W +GK + S+D G L I + G Y C + AG+V
Sbjct: 32879 PRPTAIWTKDGKAITQGGKYKLSEDKGGFF-----LEIHKTDTSDSGLYTCTVKNSAGSV 32933
Query: 116 ASVPATVTLANLQDF---KLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEA 172
+S +T+ ++D K+ Q E+ AV+ E KA +K EA
Sbjct: 32934 SS-SCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQ---EEISQKALRSEEIKMS--EA 32987
Query: 173 SRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEV-KTSGSSDRLRVRRSTAEAARI 231
L + +++ + + + + V +E+ KTS +S+ +R AE
Sbjct: 32988 KSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTH---AEIKAF 33044
Query: 232 IYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN----LLID 287
+ + + +GQ L+L+ +G V W +G +T + R+ +S L I
Sbjct: 33045 -----STQMSINEGQRLVLKANIAGATD--VKWVLNGVELTNSEEYRYGVSGSDQTLTIK 33097
Query: 288 TTSEEDSGTYRCMADNGVGQPGAAVIL-YNVQVFEPPEVTMELSQLVIPWGQSAKLTCEV 346
S D G C++ G L + ++ + P + I GQ+ TCE+
Sbjct: 33098 QASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEI 33157
Query: 347 RGNPPPSVLWLRNAVPLISSQRLRLSRR----ALRVLSMGPEDEGVYQCMAENEVGSAHA 402
G P P + W +N +P+ S + +SR +L + + D G Y A+N G A
Sbjct: 33158 SGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSA 33217
Query: 403 VVQL 406
L
Sbjct: 33218 TASL 33221
Score = 67.0 bits (162), Expect = 9e-11
Identities = 58/212 (27%), Positives = 92/212 (43%), Gaps = 39/212 (18%)
Query: 487 DSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYE 546
DS L W P + G +P+ YVV+ R+V+ + WT T+ L G Y
Sbjct: 13502 DSVHLTWEPPDDDGG-SPLTGYVVEKREVSRKT--WTKVMDFVTDLEFTVPDLVQGKEYL 13558
Query: 547 VEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPP 606
++ A N G G+ A V P + S P + P
Sbjct: 13559 FKVCARNKCGPGEPAYVD--------------------------EPVNMSTP----ATVP 13588
Query: 607 EAPDRPTISTASETSVYVTWIP-RGNGGFPIQSFRVEYKKLKKVGD-WILATSAIPPSRL 664
+ P+ + S+++TW P + +GG I+ + VE + + D W+ P +
Sbjct: 13589 DPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVE--RCPRGSDKWVACGE--PVAET 13644
Query: 665 SVEITGLEKGTSYKFRVRALNMLGESEPSAPS 696
+E+TGLE+G Y +RV+ALN G S+PS P+
Sbjct: 13645 KMEVTGLEEGKWYAYRVKALNRQGASKPSRPT 13676
Score = 66.6 bits (161), Expect = 1e-10
Identities = 76/329 (23%), Positives = 131/329 (39%), Gaps = 54/329 (16%)
Query: 485 KTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSL 544
K +S L W + G + I +YV+ R + +W A + R + +L P
Sbjct: 15510 KAESCYLTWDAPLDNGG-SEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQ 15568
Query: 545 YEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLS 604
YE + A N G K ++ DP
Sbjct: 15569 YEFRVRAVNKYGISDEC-----------------KSDKVVIQDP--------------YR 15597
Query: 605 PPEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSR 663
P P +P + ++ S+ V+W P NGG PI + +E K ++ + S P ++
Sbjct: 15598 LPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPITGYWLE--KREEGSPYWSRVSRAPITK 15655
Query: 664 LSVE-----ITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYI 718
+ ++ + L +G Y+FR A+N G PS PS P V ++ P P
Sbjct: 15656 VGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVA---GDPIF--PPGPPSC 15710
Query: 719 TFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHS-- 776
+++I L W PA + +PI G+ + + +D+K+ + E DK +
Sbjct: 15711 PEVKDKTKSSISLGWK-PPAKDGGSPIKGYIV---EMQEEGTTDWKR-VNEPDKLITTCE 15765
Query: 777 --ISHLQPETSYDIKMQCFNEGGESEFSN 803
+ +L+ Y +++ NE GESE S+
Sbjct: 15766 CVVPNLKELRKYRFRVKAVNEAGESEPSD 15794
Score = 66.2 bits (160), Expect = 2e-10
Identities = 83/354 (23%), Positives = 132/354 (37%), Gaps = 72/354 (20%)
Query: 487 DSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYE 546
+S L W P + G + I YVV+ R S+ W T+L P Y
Sbjct: 13798 ESCLLTWNPPRDDGG-SKITNYVVERR--ATDSEVWHKLSSTVKDTNFKATKLIPNKEYI 13854
Query: 547 VEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPP 606
+AA N G G+ ASP ++ + PP
Sbjct: 13855 FRVAAENMYGVGEPVQ---------------------------ASPITAKY----QFDPP 13883
Query: 607 EAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLS 665
P R S ++ +V +TW P +GG PI + VE +L D + + +P +
Sbjct: 13884 GPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVE--RLDPDTDKWVRCNKMPVKDTT 13941
Query: 666 VEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPY----ITFT 721
+ GL Y+FRV A N+ G +PS + P ++ + P+ P+ T
Sbjct: 13942 YRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILI--------KDPIDPPWPPGKPTVK 13993
Query: 722 DAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQ 781
D V +T++ L W P + I + I T +D ++ + H + L
Sbjct: 13994 D-VGKTSVRLNWTK-PEHDGGAKIESYVIEMLKTGTD---EWVRVAEGVPTTQHLLPGLM 14048
Query: 782 PETSYDIKMQCFNEGGE---SEFSNVMICETKARKSSGQPGRLPPPTLAPPQPP 832
Y +++ N+ GE SE S+ ++C K L PP PP
Sbjct: 14049 EGQEYSFRVRAVNKAGESEPSEPSDPVLCREK---------------LYPPSPP 14087
Score = 65.1 bits (157), Expect = 4e-10
Identities = 41/140 (29%), Positives = 66/140 (47%), Gaps = 8/140 (5%)
Query: 275 NKTRFLLSNLLIDTTSEEDSGTYRCMADN--GVGQPGAAVILYNVQVF--EPPEVTMELS 330
NK R I E +R A+N G+ +P + ++ E P + E+
Sbjct: 30481 NKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMK 30540
Query: 331 QLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLS----RRALRVLSMGPEDE 386
+ G++A+L+C++ G P P + W R LI S++ ++S L V++ EDE
Sbjct: 30541 DVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDE 30600
Query: 387 GVYQCMAENEVGSAHAVVQL 406
GVY C+A NEVG +L
Sbjct: 30601 GVYTCIATNEVGEVETSSKL 30620
Score = 64.7 bits (156), Expect = 5e-10
Identities = 72/309 (23%), Positives = 115/309 (37%), Gaps = 40/309 (12%)
Query: 141 DEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGN--LQIVNASQEDEGMY 198
+EG C + QV + LE S + G L + + ++ D+G Y
Sbjct: 31580 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTY 31639
Query: 199 KCAAYNPVTQ-----EVKTSGSSD---------RLRVRRSTAEAARIIYPPEAQTIIVTK 244
+C N + E+ G + +++R T + PPE + K
Sbjct: 31640 RCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNK 31699
Query: 245 ----GQSLILECVASGIPPPRVTWAKDGSSVT-GYNKTRFL------LSNLLIDTTSEED 293
G+++ + P P VTW K G + G N ++ L L I++ + +D
Sbjct: 31700 TAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDD 31759
Query: 294 SGTYRCMADNGVGQPGAAVILYNVQVFEPP-EVTME------LSQLVIPWGQSAKLTCEV 346
Y +A N G+ L V + PP + T+ L+ GQS V
Sbjct: 31760 DAEYTVVARNKYGEDSCKAKL-TVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRV 31818
Query: 347 RGNPPPSVLWLRNAVPLISSQRLR-----LSRRALRVLSMGPEDEGVYQCMAENEVGSAH 401
G PPP++ W ++ PL + L AL + PED G Y+ A N GS
Sbjct: 31819 SGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTS 31878
Query: 402 AVVQLRTSR 410
L+ R
Sbjct: 31879 CQAHLQVER 31887
Score = 64.3 bits (155), Expect = 6e-10
Identities = 73/291 (25%), Positives = 113/291 (38%), Gaps = 51/291 (17%)
Query: 185 LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARI-IYPPEA----QT 239
L ++ A ED +Y C A N V T+ +S + V + + +YPP Q
Sbjct: 3296 LLLIEAFPEDAAVYTCEAKNDYG--VATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQD 3353
Query: 240 IIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTS-------EE 292
+ ++GQ +C SG +V+W + +RF DT E
Sbjct: 3354 TVTSEGQPARFQCRVSGTDL-KVSWYSKDKKI---KPSRFFRMTQFEDTYQLEIAEAYPE 3409
Query: 293 DSGTYRCMADNGVGQPGAAVIL----------------YNVQVFEPPEVTMELSQLVIPW 336
D GTY +A N VGQ + L +++ P + ++ L +
Sbjct: 3410 DEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVAL 3469
Query: 337 GQSAKLTCEVRGNPPPSVLWLRNAVPLISSQR--LRLSR--RALRVLSMGPEDEGVYQCM 392
G AK TCE++ P W + + S + +R S+ +L +L D G Y C
Sbjct: 3470 GHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCK 3529
Query: 393 AENEVGSAHAVVQLRT---------SRP-SITPRLWQDAEL---ATGTPPV 430
A NE GS L SRP S+T + + A+ TGTP +
Sbjct: 3530 ASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVI 3580
Score = 64.3 bits (155), Expect = 6e-10
Identities = 74/342 (21%), Positives = 133/342 (38%), Gaps = 42/342 (12%)
Query: 154 ESHPKAQVRYSVKQEWLEASRGNYLIMPSG--NLQIVNASQEDEGMYK--CAAYNPVTQE 209
+S P A+V++ L+ S + SG L+I++ +D G Y+ C Y +
Sbjct: 32398 QSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASD 32457
Query: 210 VKT----SGSSDRLRVRRSTAEAARIIYPP----EAQTIIVTKGQSLILECVASGIPPPR 261
T G +R E R ++P EA + K S + + +
Sbjct: 32458 YATLDVTGGDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQ 32517
Query: 262 VTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFE 321
+T ++ S ++ + + S L + + EE S T + ++
Sbjct: 32518 MTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRK------------------IKTTL 32559
Query: 322 PPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLS----RRALR 377
+ + + + G+SA+ +C+ G P P+V WLR L +S R +++ +
Sbjct: 32560 AARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFE 32619
Query: 378 VLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPP--VSPSKL 435
+ S+ DEG Y + EN G A L + +T + P SP +
Sbjct: 32620 ISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAV 32679
Query: 436 GNPEQMLRGQPALPR--PPTSVGPASPQCPGEKGQGAPAEAP 475
+P+++ +P+ P+ PT P P EK Q P AP
Sbjct: 32680 KSPKRVKSPEPSHPKAVSPTETKPT----PTEKVQHLPVSAP 32717
Score = 63.2 bits (152), Expect = 1e-09
Identities = 53/197 (26%), Positives = 81/197 (41%), Gaps = 26/197 (13%)
Query: 264 WAKDGSSVTGYNKTRFL------LSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNV 317
W KDG + + R + + I T + D+G Y +A G+ ++V LY V
Sbjct: 3179 WYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVA----GRNRSSVTLY-V 3233
Query: 318 QVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL----SR 373
EPP+V EL + + G+ A+ + G P P + W + L + + +
Sbjct: 3234 NAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQE 3293
Query: 374 RALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPS 433
L ++ PED VY C A+N+ G A L P + D E+ PV P
Sbjct: 3294 YTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVS---PDQEM-----PVYPP 3345
Query: 434 KLGNPEQ---MLRGQPA 447
+ P Q GQPA
Sbjct: 3346 AIITPLQDTVTSEGQPA 3362
Score = 63.2 bits (152), Expect = 1e-09
Identities = 70/308 (22%), Positives = 117/308 (37%), Gaps = 42/308 (13%)
Query: 498 EGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGE 557
E G +PI Y+V+ R V W + T+T L GSLY +AA N G+
Sbjct: 14108 EKDGGSPITNYIVEKRDVRRKG--WQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQ 14165
Query: 558 GQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTA 617
+ E + D +P PP A +
Sbjct: 14166 SDYTEI----------------EDSVLAKDTFTTP-----------GPPYAL---AVVDV 14195
Query: 618 SETSVYVTWIP-RGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTS 676
++ V + W P + +GG PIQ + +E KK + W+ A P + +T + +GT
Sbjct: 14196 TKRHVDLKWEPPKNDGGRPIQRYVIE-KKERLGTRWVKAGKTAGPD-CNFRVTDVIEGTE 14253
Query: 677 YKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYI 736
+F+VRA N G PS P+ + + P + P I + W
Sbjct: 14254 VQFQVRAENEAGVGHPSEPTEILSIEDPTS-----PPSPPLDLHVTDAGRKHIAIAWK-P 14307
Query: 737 PASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEG 796
P N +PI G+++ P ++ ++ D + + P+ Y ++++ N
Sbjct: 14308 PEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIK-DLKFKVEEGVVPDKEYVLRVRAVNAI 14366
Query: 797 GESEFSNV 804
G SE S +
Sbjct: 14367 GVSEPSEI 14374
Score = 62.4 bits (150), Expect = 2e-09
Identities = 88/439 (20%), Positives = 163/439 (37%), Gaps = 113/439 (25%)
Query: 275 NKTRFLLSNLLIDTTSEEDSGTYRCMADNGVG------QPGAAVILYNVQVFEPPEVTME 328
N + L + + +E+ + +R +A N G +P A+ + E P++ ++
Sbjct: 21407 NFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDD--VEAPKIKVD 21464
Query: 329 LS---QLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPE- 384
+ +++ G++ +L +V G PPP++ W ++ L + +L + + +
Sbjct: 21465 VKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDS 21524
Query: 385 ---DEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQM 441
D G Y A N G A + ++
Sbjct: 21525 TRRDSGAYTLTATNPGGFAKHIFNVKV--------------------------------- 21551
Query: 442 LRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSG 501
L RP P E P+ ++ + K L W P + G
Sbjct: 21552 ------LDRP------------------GPPEGPLAVTEVTSEKC---VLSWFPPLDDGG 21584
Query: 502 RAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTA 561
A I +Y+V+ R+ + + WT +L +T+L G+ Y + A N G G+
Sbjct: 21585 -AKIDHYIVQKRETSRLA--WTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPL 21641
Query: 562 MVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETS 621
+ P + P PP+ P P ++T ++ S
Sbjct: 21642 E---------------------------SEPVLAVNP----YGPPDPPKNPEVTTITKDS 21670
Query: 622 VYVTW-IPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFR 680
+ V W P +GG I ++ VE + K G + + + L +++GL +G Y+FR
Sbjct: 21671 MVVCWGHPDSDGGSEIINYIVERRD--KAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFR 21728
Query: 681 VRALNMLGESEPSAPSRPY 699
+ A N G S PS P+ P+
Sbjct: 21729 IMAENAAGISAPS-PTSPF 21746
Score = 62.0 bits (149), Expect = 3e-09
Identities = 134/629 (21%), Positives = 224/629 (35%), Gaps = 145/629 (23%)
Query: 93 ITALNNHTVGR-YQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACH 151
+TA N + +G Q + V P +T+ ++ + + +G + +I
Sbjct: 23107 VTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYI 23166
Query: 152 LPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVK 211
+ + Q ++S K W E +R + S I N +Q +E +++ A N
Sbjct: 23167 V-----EMQAKHSEK--WSECAR-----VKSLQAVITNLTQGEEYLFRVVAVNE------ 23208
Query: 212 TSGSSDRLRVRRSTAEAARIIYP---PEAQTIIVTKGQSLILECVASGIPPPRVTWAKDG 268
G SD + +I P P + V GQ L +E SG P P +TW KDG
Sbjct: 23209 -KGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDG 23267
Query: 269 ---SSVTGYNKTRFL-LSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPE 324
T N T L L+ L I T ++D G Y N VGQ A++ + + +PP+
Sbjct: 23268 LPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPK 23327
Query: 325 VTMEL-----SQLVIPW------GQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSR 373
++ + + W G V+ + +W ++S+ ++R
Sbjct: 23328 GPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRDTTTTVW-----DVVSA---TVAR 23379
Query: 374 RALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPS 433
L+V + E ++ AEN G + A+ S P + +++
Sbjct: 23380 TTLKVTKLKTGTEYQFRIFAENRYGQSFAL----ESDPIVAQYPYKE------------- 23422
Query: 434 KLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVW 493
P PP G P I DS + W
Sbjct: 23423 ---------------PGPP----------------GTPFATAI--------SKDSMVIQW 23443
Query: 494 RPRHE--GSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAA 551
HE +G +P++ Y ++ RK NS ++ + + L+ G YE + A
Sbjct: 23444 ---HEPVNNGGSPVIGYHLE-RKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYA 23499
Query: 552 YNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDR 611
N G G+ + + E + RD P + P
Sbjct: 23500 ENIVGVGKAS---------------KNSECYVARD------------------PCDPPGT 23526
Query: 612 PTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITG 670
P + + W P +GG I + VE + L G W+ A S ++G
Sbjct: 23527 PEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPD-GRWMKA-SFTNVIETQFTVSG 23584
Query: 671 LEKGTSYKFRVRALNMLGE-SEPSAPSRP 698
L + Y+FRV A N G S+PS + P
Sbjct: 23585 LTEDQRYEFRVIAKNAAGAISKPSDSTGP 23613
Score = 61.6 bits (148), Expect = 4e-09
Identities = 98/430 (22%), Positives = 162/430 (37%), Gaps = 97/430 (22%)
Query: 453 TSVGPASPQCPGEKGQGAPAEAPIILSSPRT------SKTDSYELVW-RPRHEGSGRAPI 505
T++ A P P + + A A P P + S L W +P ++G +PI
Sbjct: 19563 TAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGG--SPI 19620
Query: 506 LYYVVKHRKVTNSSDDWTISGIPAN--QHRLTLTRLDPGSLYEVEMAAYNCAG------- 556
+ Y+V+ ++ SD+W +P N + R +T L + Y+ + A N G
Sbjct: 19621 IGYLVEVKRA--DSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDV 19678
Query: 557 -------------EGQT-----------AMVTFR----TGRRPKPEIMASKEQQIQRDDP 588
EG+ A VT R RP P+I SK RD
Sbjct: 19679 PDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRI 19738
Query: 589 GASPQSS-----------SQPDHGR--------------------LSPPEAPDRPTISTA 617
G +S+ ++ D G+ L P P T+
Sbjct: 19739 GLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEI 19798
Query: 618 SETSVYVTWIPRG-NGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTS 676
S+ S YVTW P +GG PI ++ V+ + ++ W T+ S+ S + LE+G S
Sbjct: 19799 SKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKS-WSTVTTEC--SKTSFRVANLEEGKS 19855
Query: 677 YKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYI 736
Y FRV A N G +P S G V + V +V++++ + W
Sbjct: 19856 YFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVR--------SVSKSSCSIGWKK- 19906
Query: 737 PASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEG 796
P S+ + I G+ + D + + + +++ +S L Y ++ NE
Sbjct: 19907 PHSDGGSRIIGYVV-----DFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENEN 19961
Query: 797 GESEFSNVMI 806
GE S + +
Sbjct: 19962 GEGTPSEITV 19971
Score = 61.2 bits (147), Expect = 5e-09
Identities = 82/336 (24%), Positives = 121/336 (36%), Gaps = 79/336 (23%)
Query: 146 AVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNP 205
A + L + ++ SVK ++ S P+ Q A D YK A
Sbjct: 840 ATLQKELSATSSAQKITKSVKAPTVKPSETRVRAEPTPLPQFPFADTPDT--YKSEAGVE 897
Query: 206 VTQEVKTSGSSDRLRVRR---------STAEAARIIYPPEA-----------QTIIVTKG 245
V +EV S + +R R E AR+ P E + + V +G
Sbjct: 898 VKKEVGVSITGTTVREERFEVLHGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEG 957
Query: 246 QSLILECVASGIPPPRVTWAKDG----SSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMA 301
+S+ LEC SG P P VTW ++ SS+ + ++ L+I EDSG + C A
Sbjct: 958 ESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCSA 1017
Query: 302 DNGVGQPGAAVILYNVQVFE---------------------------------------- 321
N G + L VQV E
Sbjct: 1018 VNEAGTVSTSCYL-AVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGP 1076
Query: 322 -----PPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLS---- 372
P +T + Q ++ G S C+V GNP P V W ++ VPL + R ++S
Sbjct: 1077 GEPAAPYFITKPVVQKLVE-GGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQ 1135
Query: 373 -RRALRVLSMG-PEDEGVYQCMAENEVGSAHAVVQL 406
V+SM +D G Y + N+ G A L
Sbjct: 1136 TGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171
Score = 60.8 bits (146), Expect = 7e-09
Identities = 136/623 (21%), Positives = 227/623 (36%), Gaps = 134/623 (21%)
Query: 297 YRCMADNGVGQPGAAVILYNVQ---VFEPPEVTMELS---QLVIPWGQSAKLTCEVRGNP 350
+R A N GQ + VQ + E PE+ ++++ ++ G+ ++ +G P
Sbjct: 27240 FRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRP 27299
Query: 351 PPSVLWLRNAVPLISSQRLRL----SRRALRVLSMGPEDEGVYQCMAENEVG----SAHA 402
PP+V W ++ L S R + S L + + D G Y EN VG S +
Sbjct: 27300 PPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVS 27359
Query: 403 VVQLRT------------SRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPR 450
V L T SR ++T LW D L G P+ + + R +
Sbjct: 27360 VKVLDTPAACQKLQVKHVSRGTVT-LLW-DPPLIDGGSPIINYVIEKRDATKRTWSVVSH 27417
Query: 451 PPTSVG----PASPQCP--------GEKGQGAPAE-----------APIILSSPRTSKTD 487
+S S + P E G G P E API S + S
Sbjct: 27418 KCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKT 27477
Query: 488 SYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEV 547
S L W + + G + I YVV+ + W+ +GI + + +++L S+ E
Sbjct: 27478 SVILSWT-KPDFDGGSVITEYVVERKG--KGEQTWSHAGI-SKTCEIEVSQLKEQSVLEF 27533
Query: 548 EMAAYNCAGEGQT------------------------AMVTFRTGR----------RPKP 573
+ A N G A VT R G +PKP
Sbjct: 27534 RVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKP 27593
Query: 574 EI------MASKEQQIQR----DDPGASPQSSSQPDHG---------------------R 602
I + KE + R ++ +++ +HG
Sbjct: 27594 SISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVIT 27653
Query: 603 LSPPEAPDRPT-ISTASETSVYVTW-IPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIP 660
L PP P P SV ++W +P NGG I + +E ++ + +W + S++
Sbjct: 27654 LGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQT-NWKMVCSSV- 27711
Query: 661 PSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITF 720
+R + ++ L K Y+FRVRA N G S+P S +V+ + R+ P G + +
Sbjct: 27712 -ARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSS--IIVAKHQFRIPGPP--GKPVIY 27766
Query: 721 TDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHL 780
V + L W P + + + GF++ + +S + G +Y + L
Sbjct: 27767 N--VTSDGMSLTW-DAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREY--RATGL 27821
Query: 781 QPETSYDIKMQCFNEGGESEFSN 803
Y ++ N G S S+
Sbjct: 27822 VEGLDYQFRVYAENSAGLSSPSD 27844
Score = 60.5 bits (145), Expect = 9e-09
Identities = 92/405 (22%), Positives = 145/405 (35%), Gaps = 96/405 (23%)
Query: 298 RCMADNGVGQPGAAVILYNVQVFEP---PEVTMELSQLVIPWGQSAKLTCEVRGNPPPSV 354
R A N +G + I NV +P P + +E +++ G+ + R P P+V
Sbjct: 14359 RVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTV 14418
Query: 355 LWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSIT 414
W ++ + +S RL + +N+ SAH V +
Sbjct: 14419 SWHKDGKEVKASDRLTM----------------------KNDHISAHLEVPKSVRADAGI 14456
Query: 415 PRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEA 474
+ + +L + T ++ +G P GP
Sbjct: 14457 YTITLENKLGSATASINVKVIGLP-----------------GPCKD-------------- 14485
Query: 475 PIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRL 534
I +S T S +L W P E G PIL+YV++ R+ + +SG N+
Sbjct: 14486 --IKASDITKS--SCKLTWEPP-EFDGGTPILHYVLERREAGRRTYIPVMSG--ENKLSW 14538
Query: 535 TLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQS 594
T+ L P Y + A N G G E + K I +D
Sbjct: 14539 TVKDLIPNGEYFFRVKAVNKVGGG---------------EYIELKNPVIAQDPK------ 14577
Query: 595 SSQPDHGRLSPPEAPDRPTISTASETSVYVTW-IPRGNGGFPIQSFRVEYKKLKKVGDWI 653
PP+ P + + ++ +TW P +GG I + +E K K W
Sbjct: 14578 ---------QPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIE-KIAKGEERWK 14627
Query: 654 LATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRP 698
+ P L+ GLE+G Y+FRVRA N G SEPS + P
Sbjct: 14628 RCNEHLVPI-LTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPP 14671
Score = 60.5 bits (145), Expect = 9e-09
Identities = 144/660 (21%), Positives = 241/660 (36%), Gaps = 136/660 (20%)
Query: 272 TGYNKTRFLLSNLLIDTTSEEDSGTYRCMADN--GVGQP----GAAVILYNVQVFEPPEV 325
TG +F ++ L E +R A N GVG+P G+ V + EPPE+
Sbjct: 25056 TGLQGKQFTVTKL-----KENTEYNFRICAINSEGVGEPATLPGSVVAQERI---EPPEI 25107
Query: 326 TMELSQ---LVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL--SRRALRVLS 380
++ +V+ + +L ++G P P V W + L ++ + S L + +
Sbjct: 25108 ELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLVIDN 25167
Query: 381 MGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITP------RLWQDAELATGTPPV--SP 432
+ D G Y EN GS A V +R P + +D+ + PP+
Sbjct: 25168 VTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGG 25227
Query: 433 SKLGN-----PEQMLRGQPALPRPPTS----VGPASPQCP--------GEKGQGAPAEA- 474
+K+ N E + + T + C E G G PAE
Sbjct: 25228 AKITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETT 25287
Query: 475 -PIILSSP-----RTSKTD----SYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDW-- 522
P+ +S P R + D + + W + E G + I YVV+ + T S+ W
Sbjct: 25288 EPVKVSEPPLPPGRVTLVDVTRNTATIKWE-KPESDGGSKITGYVVEMQ--TKGSEKWST 25344
Query: 523 ---------TISGIPANQHRLTLT-------RLDPGSL------YEVEM----------- 549
TISG+ A + + R DP L ++E+
Sbjct: 25345 CTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTF 25404
Query: 550 -------------------AAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGA 590
A N +GQT T R + + ++ ++D G
Sbjct: 25405 NVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGT 25464
Query: 591 SPQSSSQPDHGRLSP--------PEAPDRPTISTASETSVYVTWIP-RGNGGFPIQSFRV 641
S P P P I S S+ ++W P +GG I ++ V
Sbjct: 25465 YELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIV 25524
Query: 642 EYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVV 701
E K+ W + + A+ +R S++I L G+ Y+FRV A N G+S S S VV
Sbjct: 25525 EKKETTST-TWHIVSQAV--ARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSA--VV 25579
Query: 702 SGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDS 761
+ Y P P ++T+++ W +P ++ + + G+++ Y+ S S
Sbjct: 25580 AEYP----FSPPGPPGTPKVVHATKSTMLVTWQ-VPVNDGGSRVIGYHLEYKERSSILWS 25634
Query: 762 DYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICE-TKARKSSGQPGR 820
K ++ + +S L Y+ ++ N G + S CE AR PG+
Sbjct: 25635 KANKILIADTQM--KVSGLDEGLMYEYRVYAENIAGIGKCSK--SCEPVPARDPCDPPGQ 25690
Score = 60.1 bits (144), Expect = 1e-08
Identities = 152/684 (22%), Positives = 231/684 (33%), Gaps = 175/684 (25%)
Query: 240 IIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLL------SNLLIDTTSEED 293
+ V G ++ LE G P P V W KD + R + S + D
Sbjct: 18211 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSD 18270
Query: 294 SGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPS 353
G Y A N G + V V V + P L + + + C V +PP
Sbjct: 18271 GGKYVVTATNTAG---SFVAYATVNVLDKPGPVRNLKIVDVSSDR-----CTVCWDPPED 18322
Query: 354 V--LWLRNAV-PLISSQRLRLSRRALRVLSMGPE-------DEGVYQCMAENEVGSAHAV 403
++N + ++R+ S + VL+ G +E +++ AEN++G+
Sbjct: 18323 DGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPT 18382
Query: 404 VQL------------RTSRPSITPR-------LWQDAELATG---------------TPP 429
R P +T +W E G T
Sbjct: 18383 ESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRW 18442
Query: 430 VSPSKLGNPEQMLRGQPALP--------RPPTSVGPASPQCPGEKGQGAPAEAPIILSSP 481
V +K PE+ ++ Q LP + +G P P A+ PI P
Sbjct: 18443 VPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRP---VVAKDPIEPPGP 18499
Query: 482 RTS------KTDSYELVW-RPRHEGSGRAPILYYVVKHR-KVTNSSDD--WTISGIPANQ 531
T+ S L W +P ++G API+ YVV+ R K+ ++S D W A
Sbjct: 18500 PTNFRVVDTTKHSITLGWGKPVYDGG--APIIGYVVEMRPKIADASPDEGWKRCNAAAQL 18557
Query: 532 HR--LTLTRLDPGSLYEVEMAAYNCAGEGQTA-------------------------MVT 564
R T+T LD YE + A N G G+ A +V
Sbjct: 18558 VRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVI 18617
Query: 565 FRTG----------RRPKPEIMASK--------EQQIQ--------------RDDPGASP 592
R G RP P++ K + Q+ RDD G
Sbjct: 18618 VRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYS 18677
Query: 593 QSSSQPDHGR--------LSPPEAPDRPTISTASETSVYVTWIPRGN-GGFPIQSFRVEY 643
+ P + L P +S ++TS +V+W P N GG + + VE
Sbjct: 18678 LTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEK 18737
Query: 644 KKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSG 703
++ + W T + + S +T L G Y FRV A+N G P+ +P + S
Sbjct: 18738 READR-KTWSTVTPEV--KKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASD 18794
Query: 704 YSGRVYERPVAGPYITFTDAVNETT---IMLKWMYIPASNNNTPIHGFYIYYR----PTD 756
P++ P V E T L W+ P + I G+ YR P D
Sbjct: 18795 --------PLSEPDPPRKLEVTEMTKNSATLAWL-PPLRDGGAKIDGYITSYREEEQPAD 18845
Query: 757 SDNDSDYKKD-------MVEGDKY 773
+ KD + EG KY
Sbjct: 18846 RWTEYSVVKDLSLVVTGLKEGKKY 18869
Score = 59.7 bits (143), Expect = 2e-08
Identities = 111/492 (22%), Positives = 182/492 (36%), Gaps = 116/492 (23%)
Query: 275 NKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFE---PPEVTMELS- 330
NK ++ L++ E +R A N +G+ ++ L NV + + PP + + LS
Sbjct: 15345 NKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPL-NVVIQDDEVPPTIKLRLSV 15403
Query: 331 ---QLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPL--------ISSQRLRLS--RRALR 377
+ + G+ + +V G P P + W +N + I+ + + S + L
Sbjct: 15404 RGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELS 15463
Query: 378 VLSMGPEDEGVYQCMAENEVGSAHAVVQLRT-SRPSITPR-------------LWQDAEL 423
+ ED+G Y A N +GS V + RPS PR L DA L
Sbjct: 15464 IPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRPS-PPRNLAVTDIKAESCYLTWDAPL 15522
Query: 424 ATG------------------------TPPVSPSKLGNPEQMLRGQPALPRPPTSVGPAS 459
G T + G + + GQ + S
Sbjct: 15523 DNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGIS 15582
Query: 460 PQCPGEK-------GQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKH 512
+C +K P P +L+ + S S W P + G +PI Y ++
Sbjct: 15583 DECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVS----WTPPLDNGG-SPITGYWLEK 15637
Query: 513 RKVTNSSDDWT-ISGIPANQHRL-----TLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFR 566
R+ S W+ +S P + L + RL G Y+ A N AG G
Sbjct: 15638 RE--EGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIG-------- 15687
Query: 567 TGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTW 626
P E + P+ + P + PP P P + +++S+ + W
Sbjct: 15688 ----PPSE--------------PSDPEVAGDP----IFPPGPPSCPEVKDKTKSSISLGW 15725
Query: 627 IPRG-NGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRL----SVEITGLEKGTSYKFRV 681
P +GG PI+ + VE ++ + DW P +L + L++ Y+FRV
Sbjct: 15726 KPPAKDGGSPIKGYIVEMQE-EGTTDWKRVNE---PDKLITTCECVVPNLKELRKYRFRV 15781
Query: 682 RALNMLGESEPS 693
+A+N GESEPS
Sbjct: 15782 KAVNEAGESEPS 15793
Score = 59.7 bits (143), Expect = 2e-08
Identities = 121/494 (24%), Positives = 176/494 (35%), Gaps = 136/494 (27%)
Query: 228 AARIIYPPEAQ----TIIVTKGQSLILECVASGIPPPRVTWAKDG---SSVTGYNKTRFL 280
A ++ PP + T V G+ L ++ G P P VTW KD T N
Sbjct: 22141 AKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTE 22200
Query: 281 LSNLL-IDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPP----------EVTMEL 329
++LL I ED G Y N G+ A+ NV V + P EVT +
Sbjct: 22201 NNSLLTIKDACREDVGHYVVKLTNSAGE---AIETLNVIVLDKPGPPTGPVKMDEVTAD- 22256
Query: 330 SQLVIPWGQ------SAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGP 383
+ + WG S+ V + W ++S+ R + +A R L G
Sbjct: 22257 -SITLSWGPPKYDGGSSINNYIVEKRDTSTTTW-----QIVSATVARTTIKACR-LKTGC 22309
Query: 384 EDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLR 443
E + ++ AEN G + L
Sbjct: 22310 EYQ--FRIAAENRYGKS---------------------------------------TYLN 22328
Query: 444 GQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRA 503
+P + + P V PG G P++ S R DS E+ W G
Sbjct: 22329 SEPTVAQYPFKV-------PGPPG------TPVVTLSSR----DSMEVQWNEPISDGGSR 22371
Query: 504 PILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMV 563
I Y++ RK NS ++ P Q + T L+ G YE ++A N G G+ + V
Sbjct: 22372 VIGYHL--ERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKV 22429
Query: 564 TFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVY 623
+ E + RD P + P RP + SV
Sbjct: 22430 S---------------ECYVARD------------------PCDPPGRPEAIIVTRNSVT 22456
Query: 624 VTWI-PRGNGGFPIQSFRVEYKKLKKVGDWILA--TSAIPPSRLSVEITGLEKGTSYKFR 680
+ W P +GG I + VE K+L + G W+ A T+ I E+TGL + Y+FR
Sbjct: 22457 LQWKKPTYDGGSKITGYIVEKKELPE-GRWMKASFTNIIDTH---FEVTGLVEDHRYEFR 22512
Query: 681 VRALNMLGE-SEPS 693
V A N G SEPS
Sbjct: 22513 VIARNAAGVFSEPS 22526
Score = 59.7 bits (143), Expect = 2e-08
Identities = 80/337 (23%), Positives = 138/337 (40%), Gaps = 51/337 (15%)
Query: 488 SYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEV 547
S + WRP + G A IL Y+++ R+V ++ W L + L Y
Sbjct: 30244 SVRVSWRPPADDGG-ADILGYILERREVPKAA--WYTIDSRVRGTSLVVKGLKENVEYHF 30300
Query: 548 EMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPE 607
++A N G I + P + P L+PPE
Sbjct: 30301 RVSAENQFG--------------------------ISKPLKSEEPVTPKTP----LNPPE 30330
Query: 608 APDRPT-ISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLS 665
P P + +++SV ++W P+ +GG + + +E K+ W+ + +
Sbjct: 30331 PPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETS-TDKWVRHNKTQITTTMY 30389
Query: 666 VEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVN 725
+TGL Y+FR+ A N +G SE S S P V +++P + P +++
Sbjct: 30390 T-VTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKD----PFDKP-SQPGELEILSIS 30443
Query: 726 ETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVE--GDKYWHSISHLQPE 783
+ ++ L+W P + I G+++ YR DS +KK E DK + +I L
Sbjct: 30444 KDSVTLQWEK-PECDGGKEILGYWVEYR---QSGDSAWKKSNKERIKDKQF-TIGGLLEA 30498
Query: 784 TSYDIKMQCFNEGGESEFSNVMICETKARKSSGQ-PG 819
T Y+ ++ NE G S + K + +SG+ PG
Sbjct: 30499 TEYEFRVFAENETGLSRPRRTAM-SIKTKLTSGEAPG 30534
Score = 59.3 bits (142), Expect = 2e-08
Identities = 59/224 (26%), Positives = 98/224 (43%), Gaps = 16/224 (7%)
Query: 603 LSPPEAPDRPT-ISTASETSVYVTWIPRGN-GGFPIQSFRVEYKKLKKVGDWILATSAIP 660
+ P +P+ P SV V+W P + GG I + +E +++ K W S +
Sbjct: 30225 IGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVPKAA-WYTIDSRVR 30283
Query: 661 PSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITF 720
+ L V+ GL++ Y FRV A N G S+P P V E P P +
Sbjct: 30284 GTSLVVK--GLKENVEYHFRVSAENQFGISKPLKSEEP-VTPKTPLNPPEPPSNPPEVL- 30339
Query: 721 TDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHL 780
V ++++ L W P + + + G+YI + T +D + K + Y +++ L
Sbjct: 30340 --DVTKSSVSLSWSR-PKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMY--TVTGL 30394
Query: 781 QPETSYDIKMQCFNEGGESE---FSNVMICETKARKSSGQPGRL 821
P+ Y ++ N+ G SE S ++C+ K S QPG L
Sbjct: 30395 VPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPS-QPGEL 30437
Score = 58.2 bits (139), Expect = 4e-08
Identities = 102/465 (21%), Positives = 167/465 (35%), Gaps = 117/465 (25%)
Query: 242 VTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMA 301
V G S+I + P W K +S T +T+F +S L D E +R +A
Sbjct: 23545 VYDGGSMITGYIVEKRDLPDGRWMK--ASFTNVIETQFTVSGLTEDQRYE-----FRVIA 23597
Query: 302 DNGVG-----QPGAAVILYNVQVFEPPEVTME---LSQLVIPWGQSAKLTCEVRGNPPPS 353
N G I +V E P ++M+ +V+ G++ +L +V G P P+
Sbjct: 23598 KNAAGAISKPSDSTGPITAKDEV-ELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPT 23656
Query: 354 VLWLRNAVPLISSQRLRLSRRALRVLSMGPE----DEGVYQCMAENEVGSAHAVVQLRTS 409
+ WLR + S R + + L + + D G Y A N GS V ++
Sbjct: 23657 IEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVK-- 23714
Query: 410 RPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQG 469
L RP
Sbjct: 23715 -------------------------------------VLDRP------------------ 23719
Query: 470 APAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPA 529
P E P+ ++ + K L W P + G + I +YVV+ R+ + + WT+
Sbjct: 23720 GPPEGPVQVTGVTSEKC---SLTWSPPLQDGG-SDISHYVVEKRETSRLA--WTVVASEV 23773
Query: 530 NQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPG 589
+ L +T+L G+ Y + A N G G+ + + +P
Sbjct: 23774 VTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPL-----------------ESAPVLMKNPF 23816
Query: 590 ASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTW-IPRGNGGFPIQSFRVEYKKLKK 648
P PP++ + ++ ++ S+ V W P +GG I + VE K+ +
Sbjct: 23817 VLP-----------GPPKSLE---VTNIAKDSMTVCWNRPDSDGGSEIIGYIVE-KRDRS 23861
Query: 649 VGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPS 693
WI + L + +TGL + Y+FRV A N G EPS
Sbjct: 23862 GIRWIKCNKR-RITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPS 23905
Score = 57.8 bits (138), Expect = 6e-08
Identities = 72/303 (23%), Positives = 122/303 (40%), Gaps = 65/303 (21%)
Query: 467 GQGAPAEA--PIILSSP-------------RTSKTDSYELVW-RPRHEGSGRAPILYYVV 510
G G P+++ PI++ P KT S L W +P H+G A I YV+
Sbjct: 13964 GPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKT-SVRLNWTKPEHDGG--AKIESYVI 14020
Query: 511 KHRKVTNSSDDWT--ISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTG 568
+ K +D+W G+P QH L L G Y + A N AGE + +
Sbjct: 14021 EMLKT--GTDEWVRVAEGVPTTQH--LLPGLMEGQEYSFRVRAVNKAGESEPS------- 14069
Query: 569 RRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTW-I 627
P ++ + +L PP P + ++ + + W +
Sbjct: 14070 -EPSDPVLCRE----------------------KLYPPSPPRWLEVINITKNTADLKWTV 14106
Query: 628 PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNML 687
P +GG PI ++ VE + +++ G W + + ++ +V T L +G+ Y FRV A N +
Sbjct: 14107 PEKDGGSPITNYIVEKRDVRRKG-WQTVDTTVKDTKCTV--TPLTEGSLYVFRVAAENAI 14163
Query: 688 GESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHG 747
G+S+ + + + P PY V + + LKW P ++ PI
Sbjct: 14164 GQSDYTEIEDSVLAKD----TFTTP-GPPYALAVVDVTKRHVDLKW-EPPKNDGGRPIQR 14217
Query: 748 FYI 750
+ I
Sbjct: 14218 YVI 14220
Score = 57.4 bits (137), Expect = 7e-08
Identities = 171/812 (21%), Positives = 293/812 (36%), Gaps = 174/812 (21%)
Query: 167 QEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTA 226
+ W++A N++ +P + + + + ++ A N S S++ + + +
Sbjct: 20318 KSWMKA---NHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETI-ICKDEY 20373
Query: 227 EAARIIYPPEAQTIIVTK-GQSLILECVAS-GIPPPRVTWAKDGSSVTGYNKTRFLL--- 281
EA I+ P + + K G +++L ++ G P P+ +W+K G + + T+
Sbjct: 20374 EAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPT 20433
Query: 282 -SNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSA 340
S L I + +D+G Y A N G V + + V PP +E+S + + A
Sbjct: 20434 SSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPG-PVEISNVS---AEKA 20489
Query: 341 KLT----CEVRGNPPPS-VLWLRNAVPL---ISSQRLRLSRRALRVLSMGPEDEGVYQCM 392
LT E G+P S +L R L + S+ ++ R L G +E +++
Sbjct: 20490 TLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQG--NEYIFRVS 20547
Query: 393 AENEVGS-----AHAVVQLRTSRPSITPRLWQDAELATGTPPVS---PSKLGNPE----- 439
A N G + V + P P + + + T VS P G E
Sbjct: 20548 AVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYH 20607
Query: 440 ------QMLRGQPALPRPPT------------SVGPASPQCPGEKGQGAPAEA------- 474
+ LR A+ P + S G G P+EA
Sbjct: 20608 VERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMK 20667
Query: 475 -----PIILSSPRTSKTD--SYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGI 527
P S+P + T S L W H G I YVV+H+KV + + +G
Sbjct: 20668 DAAYPPGPPSNPHVTDTTKKSASLAWGKPHYDGG-LEITGYVVEHQKVGDEAWIKDTTGT 20726
Query: 528 PANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAM------------------------V 563
+ + L Y ++A N AG G+ A+ +
Sbjct: 20727 ALRITQFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTL 20786
Query: 564 TFRTGR----------RPKPEIMASKEQ---------------------QIQRDDPGASP 592
R G RP PE+ +K+ + R D G
Sbjct: 20787 VVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFV 20846
Query: 593 QSSSQPDHGRLSP-----------PEAPDRPTISTASETSVYVTW-IPRGNGGFPIQSFR 640
+ P G+ S P RPT T + SV + W +P +GG I ++
Sbjct: 20847 MTIENPA-GKKSGFVNVRVLDTPGPVLNLRPTDIT--KDSVTLHWDLPLIDGGSRITNYI 20903
Query: 641 VEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYV 700
VE ++ + +T+ + + ++TGL +G Y FRV A N G EP+ + P
Sbjct: 20904 VEKREATRKS---YSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVK 20960
Query: 701 VSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDND 760
S E P + D + ++T+ L W P + + I G+ I + SD
Sbjct: 20961 AS-------EAPSPPDSLNIMD-ITKSTVSLAWPK-PKHDGGSKITGYVIEAQRKGSDQ- 21010
Query: 761 SDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGR 820
W +H+ + ++ EG E F ++ A +S+ + R
Sbjct: 21011 -------------W---THITTVKGLECVVRNLTEGEEYTFQ--VMAVNSAGRSAPRESR 21052
Query: 821 LPPPTLAPPQPPLPETIERPVGTGAMVARSSD 852
P + Q LPE R + ++A++ D
Sbjct: 21053 ---PVIVKEQTMLPELDLRGIYQKLVIAKAGD 21081
Score = 57.4 bits (137), Expect = 7e-08
Identities = 83/412 (20%), Positives = 152/412 (36%), Gaps = 96/412 (23%)
Query: 463 PGEKGQGAPAEAPIILSSPRT------SKTDSYELVW-RPRHEGSGRAPILYYVVKHRKV 515
P E AE P+ L SP + S + + W +P +G API Y V+++K
Sbjct: 26068 PSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGG--APITGYTVEYKK- 26124
Query: 516 TNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNC--------------------- 554
+ DW S T++ L G+ Y + + N
Sbjct: 26125 -SDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEE 26183
Query: 555 ----------------AGEGQTAMVTFRTGRRPKPEIMASKEQQIQR---------DDPG 589
AG T V FR RP P ++ SK R
Sbjct: 26184 PLFDIDSEMRKTLIVKAGASFTMTVPFRG--RPVPNVLWSKPDTDLRTRAYVDTTDSRTS 26241
Query: 590 ASPQSSSQPDHGR--------------------LSPPEAPDRPTISTASETSVYVTW-IP 628
+ +++++ D G+ L P P T+ ++ S ++W +P
Sbjct: 26242 LTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDVP 26301
Query: 629 RGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLG 688
+GG P++++ +E ++ K W+ T+ +RLS ++T L++G Y FRV N G
Sbjct: 26302 ENDGGAPVKNYHIEKREASKKA-WVSVTNNC--NRLSYKVTNLQEGAIYYFRVSGENEFG 26358
Query: 689 ESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGF 748
P+ ++ E+P + P ++++ ++ L W+ + +H
Sbjct: 26359 VGIPAETKE-------GVKITEKP-SPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVH-- 26408
Query: 749 YIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESE 800
Y ++ K V + H +S L+ + Y ++ N+ G S+
Sbjct: 26409 --YVVEALEKGQKNWVKCAVAKSTH-HVVSGLRENSEYFFRVFAENQAGLSD 26457
Score = 57.0 bits (136), Expect = 1e-07
Identities = 80/365 (21%), Positives = 143/365 (39%), Gaps = 46/365 (12%)
Query: 144 NTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGN---LQIVNASQEDEGMYKC 200
N AV + ++P+ ++ + E LE S + I G+ L++ N +D+G Y+
Sbjct: 8671 NDAVFEIDIKINYPEIKLSWYKGTEKLEPS-DKFEISIDGDRHTLRVKNCQLKDQGNYRL 8729
Query: 201 AAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPP 260
+ +S +L V E Q + + +GQ+ + C S +P
Sbjct: 8730 VCGPHI--------ASAKLTVIEPAWER-------HLQDVTLKEGQTCTMTCQFS-VPNV 8773
Query: 261 RVTWAKDGSSVT--GYNKTRF--LLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYN 316
+ W ++G + G +KT + L I ED G Y C ++ +
Sbjct: 8774 KSEWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYTCKYEDLETSAELRIEA-- 8831
Query: 317 VQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSR--- 373
EP + T + +V+ QSA CEV + V W + L SQ+
Sbjct: 8832 ----EPIQFTKRIQNIVVSEHQSATFECEVSFD-DAIVTWYKGPTELTESQKYNFRNDGR 8886
Query: 374 -RALRVLSMGPEDEGVYQCMAENEV-GSAHAVVQLRTSRPSITPRLWQDAELATGTPPVS 431
+ + ++ P+DEGVY +A E G A + +L + I +L P +
Sbjct: 8887 CHYMTIHNVTPDDEGVYSVIARLEPRGEARSTAELYLTTKEI--------KLELKPPDIP 8938
Query: 432 PSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYEL 491
S++ P +R P PP P P + + P + I + + K D+ ++
Sbjct: 8939 DSRVPIPTMPIRAVPPEEIPPVVAPPIPLLLPTPEEKKPPPKR--IEVTKKAVKKDAKKV 8996
Query: 492 VWRPR 496
V +P+
Sbjct: 8997 VAKPK 9001
Score = 57.0 bits (136), Expect = 1e-07
Identities = 58/209 (27%), Positives = 87/209 (41%), Gaps = 38/209 (18%)
Query: 485 KTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSL 544
+ DS L W+ + G I YVV+ R V +S W+ + + L+ G+
Sbjct: 17322 RKDSCYLTWKEPLDDGGSV-ITNYVVERRDV--ASAQWSPLSATSKKKSHFAKHLNEGNQ 17378
Query: 545 YEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLS 604
Y +AA N G G PKP I+ DP L
Sbjct: 17379 YLFRVAAENQYGRGPFV-------ETPKP---------IKALDP--------------LH 17408
Query: 605 PPEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSR 663
PP P +T V + W P +GG PI + VEY++ + DWI + +
Sbjct: 17409 PPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQE-EGTQDWIKFKTV---TN 17464
Query: 664 LSVEITGLEKGTSYKFRVRALNMLGESEP 692
L +TGL++G +Y+FRV+A N++G P
Sbjct: 17465 LECVVTGLQQGKTYRFRVKAENIVGLGLP 17493
Score = 56.6 bits (135), Expect = 1e-07
Identities = 92/462 (19%), Positives = 154/462 (33%), Gaps = 103/462 (22%)
Query: 291 EEDSGTYRCMADNGVGQPGA-AVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGN 349
EE S + G+ P +V + + PP + + + G+ K+ G
Sbjct: 22115 EEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGR 22174
Query: 350 PPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTS 409
P P+V W ++ VPL ++ RV + E+ + H VV+L S
Sbjct: 22175 PTPAVTWHKDNVPL---------KQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNS 22225
Query: 410 RPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQG 469
L ++ +P P P + +
Sbjct: 22226 AGEAIETL---------------------NVIVLDKPGPPTGPVKMDEVT---------- 22254
Query: 470 APAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPA 529
DS L W P G + I Y+V+ R + ++ W I
Sbjct: 22255 ----------------ADSITLSWGPPKYDGGSS-INNYIVEKRDTSTTT--WQIVSATV 22295
Query: 530 NQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPG 589
+ + RL G Y+ +AA N G+
Sbjct: 22296 ARTTIKACRLKTGCEYQFRIAAENRYGKSTYL---------------------------N 22328
Query: 590 ASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKK 648
+ P + P P P P ++ +S S+ V W P +GG + + +E K+
Sbjct: 22329 SEPTVAQYP----FKVPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNS 22384
Query: 649 VGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRV 708
+ L + IP ++ TGLE+G Y+FRV A N++G +PS S YV
Sbjct: 22385 ILWVKLNKTPIPQTKFKT--TGLEEGVEYEFRVSAENIVGIGKPSKVSECYVA------- 22435
Query: 709 YERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYI 750
P P V ++ L+W P + + I G+ +
Sbjct: 22436 -RDPCDPPGRPEAIIVTRNSVTLQWKK-PTYDGGSKITGYIV 22475
Score = 56.2 bits (134), Expect = 2e-07
Identities = 139/658 (21%), Positives = 226/658 (34%), Gaps = 144/658 (21%)
Query: 297 YRCMADNGVGQPGAAVILYNVQVFEP-PEVTMELS------QLVIPWGQSAKLTCEVRGN 349
YR A+N G + IL + + E TM+LS ++++P + G
Sbjct: 13364 YRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVP--NPITILVPSTGY 13421
Query: 350 PPPSVLWLRNAVPLISSQRLR---LSRRALRVLSMGPE-DEGVYQCMAENEVGSAHAVVQ 405
P P+ W L + R++ LS A V+S D+G+Y EN V + +
Sbjct: 13422 PRPTATWCFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEID 13481
Query: 406 LRT-SRPSITPRL-----WQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVG--- 456
+ +RPS L +D+ T PP ++ + + T V
Sbjct: 13482 VNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFV 13541
Query: 457 -------PASPQ--------CPGEK-GQGAPA--EAPIILSSPRTSKTDSYELVWRPRHE 498
P Q C K G G PA + P+ +S+P T + WR R
Sbjct: 13542 TDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTA 13601
Query: 499 GS-----------GRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEV 547
S G + I Y+V+ + SD W G P + ++ +T L+ G Y
Sbjct: 13602 NSIFLTWDPPKNDGGSRIKGYIVE--RCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAY 13659
Query: 548 EMAAYNCAGEGQT-------------------------AMVTFRTGRR----------PK 572
+ A N G + A +T + G + P+
Sbjct: 13660 RVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPE 13719
Query: 573 PEIMASKEQQIQRDDPGASPQS-----------SSQPDHGR------------------- 602
P+I +K I + D + ++ S + D G
Sbjct: 13720 PKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVN 13779
Query: 603 -LSPPEAPDRPTISTASETSVYVTWIP-RGNGGFPIQSFRVEYKKLKKVGDWILATSAIP 660
L P P I+ + S +TW P R +GG I ++ VE ++ W +S +
Sbjct: 13780 VLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVE-RRATDSEVWHKLSSTVK 13838
Query: 661 PSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITF 720
+ T L Y FRV A NM G E P S + + P P
Sbjct: 13839 DTNFKA--TKLIPNKEYIFRVAAENMYGVGE------PVQASPITAKYQFDPPGPPTRLE 13890
Query: 721 TDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHL 780
+ + + L W P + +PI G+++ D+D K V+ Y + L
Sbjct: 13891 PSDITKDAVTLTWCE-PDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTY--RVKGL 13947
Query: 781 QPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIE 838
+ Y ++ N G + S S +P + P + PP PP T++
Sbjct: 13948 TNKKKYRFRVLAENLAGPGKPS-----------KSTEPILIKDP-IDPPWPPGKPTVK 13993
Score = 55.5 bits (132), Expect = 3e-07
Identities = 94/432 (21%), Positives = 157/432 (36%), Gaps = 100/432 (23%)
Query: 321 EPPEVTMELSQ-LVIPWGQSAKLTCEVRGNPPPSVLWL--RNAVPLISSQRLRLSRRA-- 375
+ P + ++LS L + G + +L VRG P P V W ++A L S R+++ RA
Sbjct: 18199 QKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADS 18258
Query: 376 --LRVLSMGPEDEGVYQCMAENEVGSAHA-----------------VVQLRTSRPSI--- 413
+ D G Y A N GS A +V + + R ++
Sbjct: 18259 SKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWD 18318
Query: 414 -------------------TPRL-WQDAELATGTPPVSPSKLGNPEQML---RGQPAL-P 449
T R+ W TP + ++L + + R + +
Sbjct: 18319 PPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGT 18378
Query: 450 RPPTSVGPASPQCPGEK-GQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYY 508
PPT P + +K G+ P E + T +VW P G++ Y+
Sbjct: 18379 GPPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMT-------VVWNPPEYDGGKSITGYF 18431
Query: 509 VVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTG 568
+ K K + S IP + R+ + L P Y+ + A N G G+ ++
Sbjct: 18432 LEKKEKHSTRWVPVNKSAIP--ERRMKVQNLLPDHEYQFRVKAENEIGIGEPSL------ 18483
Query: 569 RRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTW-I 627
P ++A DP + PP P + ++ S+ + W
Sbjct: 18484 --PSRPVVAK--------DP--------------IEPPGPPTNFRVVDTTKHSITLGWGK 18519
Query: 628 PRGNGGFPIQSFRVEYKKLKKVGD------WILATSAIPPSRLSVEITGLEKGTSYKFRV 681
P +GG PI + VE + K+ D W +A R +T L++ Y+FRV
Sbjct: 18520 PVYDGGAPIIGYVVEMR--PKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRV 18577
Query: 682 RALNMLGESEPS 693
A N +G P+
Sbjct: 18578 CAQNQVGIGRPA 18589
Score = 55.1 bits (131), Expect = 4e-07
Identities = 55/248 (22%), Positives = 99/248 (39%), Gaps = 11/248 (4%)
Query: 557 EGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTIST 616
EG+ +++ R K + + + + PG +S + P P P
Sbjct: 29191 EGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVG 29250
Query: 617 ASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGT 675
+ + + W P +GG I ++ V+ K+ KK W +++T L +G
Sbjct: 29251 TGKEHIIIQWTKPESDGGNEISNYLVD-KREKKSLRWTRVNKDYVVYDTRLKVTSLMEGC 29309
Query: 676 SYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMY 735
Y+FRV A+N G SEPS S +S P + P + T + +I L W
Sbjct: 29310 DYQFRVTAVNAAGNSEPSEASN--FISCREPSYTPGPPSAPRVVDT---TKHSISLAWTK 29364
Query: 736 IPASNNNTPIHGFYIYYRPTDSDN-DSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFN 794
P + T I G+ + + D+D + + ++ ++ L+ Y ++ N
Sbjct: 29365 -PMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEF--TVPDLKMGQKYSFRVAAVN 29421
Query: 795 EGGESEFS 802
G SE+S
Sbjct: 29422 VKGMSEYS 29429
Score = 54.7 bits (130), Expect = 5e-07
Identities = 55/194 (28%), Positives = 82/194 (42%), Gaps = 17/194 (8%)
Query: 606 PEAPDRPTISTASETSVYVTW-IPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRL 664
P P +P I + + +TW P +GG + F VE K+ + + TS P S
Sbjct: 27757 PGPPGKPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTS--PISGR 27814
Query: 665 SVEITGLEKGTSYKFRVRALNMLGESEPSAPSR-PYVVSGYSGRVYERPVAGPYITFTDA 723
TGL +G Y+FRV A N G S PS PS+ VS PV P
Sbjct: 27815 EYRATGLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVS---------PVDPPGTPDYID 27865
Query: 724 VNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPE 783
V TI LKW P + + I G+ I R N+ + + + + ++++ L P
Sbjct: 27866 VTRETITLKW-NPPLRDGGSKIVGYSIEKR---QGNERWVRCNFTDVSECQYTVTGLSPG 27921
Query: 784 TSYDIKMQCFNEGG 797
Y+ ++ N G
Sbjct: 27922 DRYEFRIIARNAVG 27935
Score = 53.9 bits (128), Expect = 8e-07
Identities = 37/95 (38%), Positives = 54/95 (56%), Gaps = 5/95 (5%)
Query: 606 PEAPDRPTISTASETSVYVTWIP-RGNGGFPIQSFRVEYKKLKKVGDWI-LATSAIPPSR 663
P AP +PTI+ ++ S V W P +GG I+++ +E K+ KK WI + T I +
Sbjct: 30825 PGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLE-KREKKQNKWISVTTEEIRETV 30883
Query: 664 LSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRP 698
SV+ L +G Y+FRV+ N+ GESE S S P
Sbjct: 30884 FSVK--NLIEGLEYEFRVKCENLGGESEWSEISEP 30916
Score = 53.5 bits (127), Expect = 1e-06
Identities = 41/169 (24%), Positives = 74/169 (43%), Gaps = 15/169 (8%)
Query: 244 KGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLS-----NLLIDTTSEEDSGTYR 298
+GQ+ + G P P W DG + + ++ +L+I + DSG +
Sbjct: 1470 EGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWT 1529
Query: 299 CMADNGVGQPGAAVILYNVQVFE---PPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVL 355
+A N G+ +VIL V+ E P +L + I G ++ GNP P ++
Sbjct: 1530 VVAQNRAGRSSISVIL-TVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIV 1588
Query: 356 WLRNAVPLISSQ--RLRL----SRRALRVLSMGPEDEGVYQCMAENEVG 398
WL+N+ ++ + ++R+ AL++ S +D Y A N+ G
Sbjct: 1589 WLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAG 1637
Score = 53.5 bits (127), Expect = 1e-06
Identities = 102/516 (19%), Positives = 173/516 (33%), Gaps = 117/516 (22%)
Query: 245 GQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNG 304
G S I+ V + + W K + T ++S L E +R A+N
Sbjct: 26402 GGSRIVHYVVEALEKGQKNWVKCAVA----KSTHHVVSGL-----RENSEYFFRVFAENQ 26452
Query: 305 VGQPGAAVILYNVQV---FEPPEVTME---LSQLVIPWGQSAKLTCEVRGNPPPSVLWLR 358
G +L V + EPPE+ M+ + + G + K+ + G P P V R
Sbjct: 26453 AGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSR 26512
Query: 359 NAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLW 418
+ VPL ++ R E+ + + + L+ S + R
Sbjct: 26513 DGVPLKATMRFN------------------------TEITAENLTINLKESVTADAGRYE 26548
Query: 419 QDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIIL 478
A ++GT + + L RP P P+++
Sbjct: 26549 ITAANSSGTTKAFINIV-----------VLDRP------------------GPPTGPVVI 26579
Query: 479 SSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTR 538
S +S L W P G Y ++K S+ WT + + + +
Sbjct: 26580 SD---ITEESVTLKWEPPKYDGGSQVTNYILLKRE---TSTAVWTEVSATVARTMMKVMK 26633
Query: 539 LDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQP 598
L G Y+ + A N G T + P
Sbjct: 26634 LTTGEEYQFRIKAENRFGISDHIDSACVTVKLP--------------------------- 26666
Query: 599 DHGRLSPPEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKVGDWILATS 657
+ P P P ++ + S+ V W P NGG + + +E K + W A
Sbjct: 26667 ----YTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLEMKDRNSIL-WQKANK 26721
Query: 658 AIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPY 717
+ + ++T + G Y+FRV A N G +PS PS P + E P
Sbjct: 26722 LVIRTT-HFKVTTISAGLIYEFRVYAENAAGVGKPSHPSEPVLAID----ACEPP---RN 26773
Query: 718 ITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYR 753
+ TD +++ ++ L W PA + + I G+ + R
Sbjct: 26774 VRITD-ISKNSVSLSWQQ-PAFDGGSKITGYIVERR 26807
Score = 52.4 bits (124), Expect = 2e-06
Identities = 117/563 (20%), Positives = 190/563 (33%), Gaps = 178/563 (31%)
Query: 238 QTIIVTKGQSLILECVASGIPPPRVTWAKDGS--SVTGYNKTRFLLSNLLIDTTSEEDSG 295
QT +V G S+ L G P P W+K S S+ T S L ++ + D+G
Sbjct: 28365 QTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAG 28424
Query: 296 TYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVL 355
Y +N G+ I + V+V + P G +T + +++
Sbjct: 28425 KYTLTVEN---NSGSKSITFTVKVLDTP-------------GPPGPITFKDVTRGSATLM 28468
Query: 356 WLRNAVPLISS---------QRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQL 406
W PL+ ++ SRR+ +V+S
Sbjct: 28469 W---DAPLLDGGARIHHYVVEKREASRRSWQVIS-------------------------- 28499
Query: 407 RTSRPSITPRLWQDAELATGTP------PVSPSKLGNPEQMLRGQPALPRPPTSVGPASP 460
T ++++ +LA G P V+ +G P +M P P + +P
Sbjct: 28500 ----EKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEM-------PEPIVATEQPAP 28548
Query: 461 QCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSD 520
P L TSK+ + +P H+G R I Y+++ R+ SD
Sbjct: 28549 --------------PRRLDVVDTSKSSAVLAWLKPDHDGGSR--ITGYLLEMRQ--KGSD 28590
Query: 521 DWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQ--------------------- 559
W +G Q T+ RL + YE + A N AG +
Sbjct: 28591 FWVEAG-HTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADL 28649
Query: 560 ----TAMVTFRTGR----------RPKPEIMASKEQQ-----------IQRDDPGASPQS 594
++T + G RP P++ E+ +D + +
Sbjct: 28650 TGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKD 28709
Query: 595 SSQPDHGRL---------------------SPPEAPDRPTISTASETSVYVTW-IPRGNG 632
S + D GR P +S+ S S ++W P+ G
Sbjct: 28710 SMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVSSVSAESCVLSWGEPKDGG 28769
Query: 633 GFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESE- 691
G I ++ VE K+ W L S++ R +++T L K Y FRV + N G S+
Sbjct: 28770 GTEITNYIVE-KRESGTTAWQLVNSSV--KRTQIKVTHLTKYMEYSFRVSSENRFGVSKP 28826
Query: 692 --------------PSAPSRPYV 700
PSAP+RP V
Sbjct: 28827 LESAPIIAEHPFVPPSAPTRPEV 28849
Score = 52.0 bits (123), Expect = 3e-06
Identities = 48/153 (31%), Positives = 69/153 (45%), Gaps = 14/153 (9%)
Query: 185 LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTK 244
L I AS DEG+ C + T+E D L + + ++A I P +Q I +
Sbjct: 33094 LTIKQASHRDEGILTCISK---TKEGIVKCQYD-LTLSKELSDAPAFISQPRSQNI--NE 33147
Query: 245 GQSLILECVASGIPPPRVTWAKDG-----SSVTGYNKTRFLLSNLLIDTTSEEDSGTYRC 299
GQ+++ C SG P P + W K+ SS +++R + S L I S DSG Y
Sbjct: 33148 GQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYS-LEIRNASVSDSGKYTI 33206
Query: 300 MADNGVGQPGAAVILYNVQVFEPP--EVTMELS 330
A N GQ A L + + E P EV + S
Sbjct: 33207 KAKNFRGQCSATASLMVLPLVEEPSREVVLRTS 33239
Score = 51.6 bits (122), Expect = 4e-06
Identities = 103/463 (22%), Positives = 160/463 (34%), Gaps = 102/463 (22%)
Query: 240 IIVTKGQSLILECVASGIPPPRVTWAKDGSSVT--GYNKTRFLLSNLLIDTTSEEDSGTY 297
I V +G + L G P P W K+G ++ T + L+I DSGTY
Sbjct: 30146 IFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTY 30205
Query: 298 RCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWL 357
+ +N G+ + + + PE +E + +
Sbjct: 30206 DLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQV----------------------- 30242
Query: 358 RNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRL 417
R++RV P D+G ++ R +
Sbjct: 30243 ----------------RSVRVSWRPPADDG------------GADILGYILERREVPKAA 30274
Query: 418 WQDAE-LATGTPPVSPSKLGNPEQMLR----GQPALPRPPTSVGPASPQCPGEKGQGAPA 472
W + GT V N E R Q + +P S P +P+ P + P+
Sbjct: 30275 WYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPE-PPS 30333
Query: 473 EAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQH 532
P +L ++S + S+ RP+ +G R YY+ RK T S+D W + N+
Sbjct: 30334 NPPEVLDVTKSSVSLSWS---RPKDDGGSRV-TGYYI--ERKET-STDKW----VRHNKT 30382
Query: 533 RLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASP 592
++T T Y G A FR I+A + + P + P
Sbjct: 30383 QITTT-------------MYTVTGLVPDAEYQFR--------IIAQNDVGLSETSPASEP 30421
Query: 593 QSSSQPDHGRLSPPEAPDRPTISTASETSVYVTW-IPRGNGGFPIQSFRVEYKKLKKVGD 651
P P P I + S+ SV + W P +GG I + VEY ++ GD
Sbjct: 30422 VVCKDP----FDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEY---RQSGD 30474
Query: 652 --WILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEP 692
W + + I GL + T Y+FRV A N G S P
Sbjct: 30475 SAWKKSNKERIKDK-QFTIGGLLEATEYEFRVFAENETGLSRP 30516
Score = 51.2 bits (121), Expect = 5e-06
Identities = 57/234 (24%), Positives = 91/234 (38%), Gaps = 30/234 (12%)
Query: 603 LSPPEAPDRP-TISTASETSVYVTWIP-RGNGGFPIQSFRVEYKKLKKVGDWILATSAIP 660
L P P P I + + ++W P + +GG P+ ++ VE + +K W + +S
Sbjct: 17601 LDVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRK-DTWGVVSSG-- 17657
Query: 661 PSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITF 720
S+ ++I L+KG Y FRVRA N +G P + +S P + P
Sbjct: 17658 SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFS------PPSPPGKPV 17711
Query: 721 TDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHL 780
+ E + W +P S+ +PI G+Y+ R E W ++
Sbjct: 17712 VTDITENAATVSWT-LPKSDGGSPITGYYMERR---------------EVTGKWVRVNK- 17754
Query: 781 QPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLP 834
P ++ EG EF + E A S P P P +PP P
Sbjct: 17755 TPIADLKFRVTGLYEGNTYEFR--VFAENLAGLSKPSPSSDPIKACRPIKPPGP 17806
Score = 51.2 bits (121), Expect = 5e-06
Identities = 148/703 (21%), Positives = 262/703 (37%), Gaps = 135/703 (19%)
Query: 168 EWLEASRGNYLIMPSGNLQIVN-----------ASQEDEGMYKCAAYN-------PVTQE 209
EWL RG+ I S +I N A + D G Y A N PV +
Sbjct: 23658 EWL---RGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVK 23714
Query: 210 V--KTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKD 267
V + ++V T+E + + P Q G S I V R+ W
Sbjct: 23715 VLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQD-----GGSDISHYVVEKRETSRLAWTVV 23769
Query: 268 GSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADN--GVGQP--GAAVILYNVQVFEPP 323
S V + ++L + E + +R MA N GVG+P A V++ N V P
Sbjct: 23770 ASEV--------VTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGP 23821
Query: 324 EVTMELSQLVIPWGQSAKLTCEVRGNPPPS------VLWL-----RNAVPLISSQRLRLS 372
++E++ + AK + V N P S + ++ R+ + I + R++
Sbjct: 23822 PKSLEVTNI-------AKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRIT 23874
Query: 373 RRALRVLSMGPEDEGVYQCMAENEVG---SAHAVVQLRTSRPSITPRLWQDAELATGTPP 429
LRV + + E ++ AEN G + A V + P P +A + T
Sbjct: 23875 DLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTK- 23933
Query: 430 VSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTS-KTDS 488
N + G+P +G C ++ + + +P+T +
Sbjct: 23934 -------NSITLAWGKPIYDGGSEILGYVVEICKADEEEWQ-------IVTPQTGLRVTR 23979
Query: 489 YELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVE 548
+E+ H+ V KV + ++ G + +L LD S E+
Sbjct: 23980 FEISKLTEHQ-----EYKIRVCALNKV-GLGEATSVPGTVKPEDKLEAPELDLDS--ELR 24031
Query: 549 MAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQ-------QIQ--------------RDD 587
AG + F+ RP PEI S+E+ QI+ R+D
Sbjct: 24032 KGIVVRAGGSARIHIPFK--GRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRND 24089
Query: 588 PG--------ASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPR-GNGGFPIQS 638
G +S S+ L P P + + S ++ W P +GG +++
Sbjct: 24090 AGKYILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKN 24149
Query: 639 FRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRP 698
+ ++ ++ + A + S+ S ++ L +G Y FRV A N G P
Sbjct: 24150 YVIDKRESTRKA---YANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVP------ 24200
Query: 699 YVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSD 758
V + + + E P +T TD V++T+ L W P + + + G+ + +P ++
Sbjct: 24201 -VETVDAVKAAEPPSPPGKVTLTD-VSQTSASLMWEK-PEHDGGSRVLGYVVEMQPKGTE 24257
Query: 759 NDSDYKKDMVEGDKYWHS-ISHLQPETSYDIKMQCFNEGGESE 800
K +V K ++ ++ L Y +++ +NE G+S+
Sbjct: 24258 -----KWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSD 24295
Score = 51.2 bits (121), Expect = 5e-06
Identities = 107/477 (22%), Positives = 167/477 (35%), Gaps = 115/477 (24%)
Query: 283 NLLIDTTSEEDSGTYRCMADNGVGQP-----GAAVILYNVQVFEPPEVTMELSQLVIPWG 337
N ++ S +R A N G+ G VI ++ + P + + + I G
Sbjct: 24269 NAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTI--QPSLKLPFNTYSIQAG 24326
Query: 338 QSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRA----LRVLSMGPEDEGVYQCMA 393
+ K+ V G P P++ W+++ PL + R+ + A L + +D G Y A
Sbjct: 24327 EDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTA 24386
Query: 394 ENEVGSAH---AVVQLRTSRPSI------------------------------------- 413
N G+A +V+ L P +
Sbjct: 24387 TNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRD 24446
Query: 414 -TPRLWQ--DAELATGTPPVSPSKLGNPEQML-----RGQPALPRPPTSVGPASP-QCPG 464
T W A +A T ++ K G Q R + P +V P + PG
Sbjct: 24447 TTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPG 24506
Query: 465 EKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWT- 523
G P + S + D + W G I Y++ + K +S W
Sbjct: 24507 PPG------TPFVTSISK----DQMLVQWHEPVNDGGTKIIGYHLEQKEK---NSILWVK 24553
Query: 524 ISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQI 583
++ P + T LD G YE +++A N G G+ + V+ E +
Sbjct: 24554 LNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVS---------------ECFV 24598
Query: 584 QRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVE 642
RD P + P RP + +V + W P +GG I + VE
Sbjct: 24599 ARD------------------PCDPPGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVE 24640
Query: 643 YKKLKKVGDWILATSAIPPSRLSVEIT--GLEKGTSYKFRVRALNMLGE-SEPSAPS 696
K L G W+ A+ + L E T GL + Y+FRV A N G SEPS S
Sbjct: 24641 KKDLPD-GRWMKASFT---NVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSS 24693
Score = 51.2 bits (121), Expect = 5e-06
Identities = 89/415 (21%), Positives = 159/415 (38%), Gaps = 46/415 (11%)
Query: 31 DLNEVPQVTVQPA---STVQKPGGTV-ILGCVVEPPRMNVTWRLNGKELNGSDDALGVLI 86
D+ E P++ + A S + K G V +L P VTWR + K L GSD +
Sbjct: 27264 DILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNL-GSDARYSIEN 27322
Query: 87 THGT--LVITALNNHTVGRYQCVARM----PAGAVASVPATVTLANLQDFKLDVQHVIEV 140
T + L I + + G+Y P + SV T A Q KL V+HV
Sbjct: 27323 TDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPAACQ--KLQVKHVSRG 27380
Query: 141 DEG---NTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGM 197
+ +I P + + R + K+ W S S + ++++ S++
Sbjct: 27381 TVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSHK----CSSTSFKLIDLSEKTPFF 27436
Query: 198 YKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTK-------GQSLIL 250
++ A N + + +++ ++ A + +T ++ G S+I
Sbjct: 27437 FRVLAENEIGIG-EPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFDGGSVIT 27495
Query: 251 ECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADN--GVGQP 308
E V TW+ G S T + + E+ +R A N G+ P
Sbjct: 27496 EYVVERKGKGEQTWSHAGISKT---------CEIEVSQLKEQSVLEFRVFAKNEKGLSDP 27546
Query: 309 GAAVILYNVQVFEPPEVTMEL---SQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLIS 365
+ ++ PEV + +Q+ + G + L +G P PS+ WL++ +PL
Sbjct: 27547 VTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKE 27606
Query: 366 SQRLRLSRR----ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPR 416
S+ +R S+ L + + E G Y + +N V + + T P P+
Sbjct: 27607 SEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPK 27661
Score = 51.2 bits (121), Expect = 5e-06
Identities = 89/420 (21%), Positives = 157/420 (37%), Gaps = 92/420 (21%)
Query: 471 PAEAPIILSSPRTSKTDSYELVW-RPRHEGSGRAPILYYVVKHRKVTNSSDDW-TISGIP 528
P P ++ TSKT + L W +P +G I+ Y+++ K DW ++
Sbjct: 28253 PPGPPTVVKVTDTSKT-TVSLEWSKPVFDGG--MEIIGYIIEMCKA--DLGDWHKVNAEA 28307
Query: 529 ANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVT------------------------ 564
+ R T+T L G Y+ ++A N AG+G + VT
Sbjct: 28308 CVKTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTH 28367
Query: 565 -FRTGR----------RPKPEIMASKE---------------------QQIQRDDPG--- 589
R G RP P + SK + R+D G
Sbjct: 28368 VVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYT 28427
Query: 590 --ASPQSSSQPDHGRLSPPEAPDRP---TISTASETSVYVTW-IPRGNGGFPIQSFRVEY 643
S S+ + + P P T + S + W P +GG I + VE
Sbjct: 28428 LTVENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEK 28487
Query: 644 KKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSG 703
++ + +++ +R ++ L +G Y FRV A+N G EP P V +
Sbjct: 28488 REASRRSWQVISEKC---TRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVAT- 28543
Query: 704 YSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDY 763
E+P + D ++++ +L W+ P + + I G+ + R SD+
Sbjct: 28544 ------EQPAPPRRLDVVD-TSKSSAVLAWLK-PDHDGGSRITGYLLEMR----QKGSDF 28591
Query: 764 KKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESE----FSNVMICETKARKSSGQPG 819
+ + ++ L +T Y+ +++ N+ G SE FS+V+I E + ++ G
Sbjct: 28592 WVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTG 28651
Score = 50.1 bits (118), Expect = 1e-05
Identities = 126/551 (22%), Positives = 198/551 (35%), Gaps = 134/551 (24%)
Query: 169 WLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEA 228
W++AS N + + +++ ++ A N K S S+ + + E
Sbjct: 23567 WMKASFTNVI---ETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAK-DEVEL 23622
Query: 229 ARIIYPPEAQ-TIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN---- 283
RI P+ + TI+V G++ LE G P P + W + + R + N
Sbjct: 23623 PRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIE--ESARCEIKNTDFK 23680
Query: 284 --LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFE---PPEVTMELSQLVIPWGQ 338
L++ D G Y A N G V NV+V + PPE ++++ +
Sbjct: 23681 ALLIVKDAIRIDGGQYILRASNVAGSKSFPV---NVKVLDRPGPPEGPVQVTGVT----- 23732
Query: 339 SAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVG 398
S K C + +PP L G D
Sbjct: 23733 SEK--CSLTWSPP---------------------------LQDGGSD------------- 23750
Query: 399 SAHAVVQLR-TSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGP 457
+H VV+ R TSR + T +E+ T + V+ GN E + R +
Sbjct: 23751 ISHYVVEKRETSRLAWTV---VASEVVTNSLKVTKLLEGN-EYVFR-----------IMA 23795
Query: 458 ASPQCPGEKGQGAPA--EAPIILSSPRTS------KTDSYELVWRPRHEGSGRAPILYYV 509
+ GE + AP + P +L P S DS + W R + G + I+ Y+
Sbjct: 23796 VNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWN-RPDSDGGSEIIGYI 23854
Query: 510 VKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSL-----YEVEMAAYNCAGEGQTAMVT 564
V+ R D I I N+ R+T RL L YE ++A N AG G+
Sbjct: 23855 VEKR------DRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGE----- 23903
Query: 565 FRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYV 624
P P + K DP + P P I ++ S+ +
Sbjct: 23904 ------PSPATVYYK-----ACDP--------------VFKPGPPTNAHIVDTTKNSITL 23938
Query: 625 TW-IPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRA 683
W P +GG I + VE K + +W + T EI+ L + YK RV A
Sbjct: 23939 AWGKPIYDGGSEILGYVVEICKADE-EEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCA 23997
Query: 684 LNMLGESEPSA 694
LN +G E ++
Sbjct: 23998 LNKVGLGEATS 24008
Score = 50.1 bits (118), Expect = 1e-05
Identities = 48/188 (25%), Positives = 82/188 (43%), Gaps = 15/188 (7%)
Query: 614 ISTASETSVYVTW-IPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLE 672
+ S SV +TW IP +GG P+ ++ VE ++ + T S+ I+GL
Sbjct: 29546 VKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKC---SKTLYRISGLV 29602
Query: 673 KGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLK 732
+GT Y FRV N+ G EP S +VS E P+ + D V ++T+ L
Sbjct: 29603 EGTMYYFRVLPENIYGIGEPCETSDAVLVS-------EVPLVPAKLEVVD-VTKSTVTLA 29654
Query: 733 WMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQC 792
W P + + + G+ + + + K ++ H+++ L Y +++
Sbjct: 29655 WEK-PLYDGGSRLTGYVL--EACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRA 29711
Query: 793 FNEGGESE 800
NE G SE
Sbjct: 29712 QNEKGVSE 29719
Score = 49.7 bits (117), Expect = 2e-05
Identities = 88/359 (24%), Positives = 136/359 (37%), Gaps = 51/359 (14%)
Query: 50 GGTVILGCVVEPPRMNVTWRLNGKELNGSDDALGVLITHG---TLVITALNNHTVGRYQC 106
G T C + + V W L GK+L SD V + G TL + + G Q
Sbjct: 12210 GETATFDCELSYEDIPVEWYLKGKKLEPSDKV--VPRSEGKVHTLTLRDVKLEDAGEVQL 12267
Query: 107 VA---RMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRY 163
A + A P L+D V+EG TAV+ C + S A+V++
Sbjct: 12268 TAKDFKTHANLFVKEPPVEFTKPLED--------QTVEEGATAVLECEV--SRENAKVKW 12317
Query: 164 SVKQEWLEASRGNYLIMPSG---NLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLR 220
+ S+ Y I+ G L I + + ED Y C A ++ KTS + L
Sbjct: 12318 FKNGTEILKSK-KYEIVADGRVRKLVIHDCTPEDIKTYTCDA-----KDFKTSCN---LN 12368
Query: 221 VRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNK---- 276
V E R + + V + + EC S +V W KDG+ + K
Sbjct: 12369 VVPPHVEFLRPL-----TDLQVREKEMARFECELSR-ENAKVKWFKDGAEIKKGKKYDII 12422
Query: 277 TRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPW 336
++ + L+I+ +D Y C G +L VF T L+ + +
Sbjct: 12423 SKGAVRILVINKCLLDDEAEYSCEV-RTARTSGMLTVLEEEAVF-----TKNLANIEVSE 12476
Query: 337 GQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL----SRRALRVLSMGPEDEGVYQC 391
+ KL CEV P V+W + +I + R + +R L + + ED G Y C
Sbjct: 12477 TDTIKLVCEV-SKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNC 12534
Score = 49.7 bits (117), Expect = 2e-05
Identities = 92/394 (23%), Positives = 142/394 (36%), Gaps = 55/394 (13%)
Query: 50 GGTVILGCVVEPPRMNVTWRLNGKELNGSDDALGVLITHG---TLVITALNNHTVGRYQC 106
G T +L C V V W NG E+ S ++ G LVI + Y C
Sbjct: 12299 GATAVLECEVSRENAKVKWFKNGTEILKSKKY--EIVADGRVRKLVIHDCTPEDIKTYTC 12356
Query: 107 VA---RMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRY 163
A + P L L D ++V E A C L S A+V++
Sbjct: 12357 DAKDFKTSCNLNVVPPHVEFLRPLTD--------LQVREKEMARFECEL--SRENAKVKW 12406
Query: 164 SVKQEWLEASRG-NYLIMPSGNLQIVNASQ---EDEGMYKCAAYNPVTQEVKTSGSSDRL 219
++ E +G Y I+ G ++I+ ++ +DE Y C EV+T+ +S L
Sbjct: 12407 F--KDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSC--------EVRTARTSGML 12456
Query: 220 RVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRF 279
V A ++ I V++ ++ L C S P V W K + +
Sbjct: 12457 TVLEEEA-----VFTKNLANIEVSETDTIKLVCEVSK-PGAEVIWYKGDEEIIETGRYEI 12510
Query: 280 LLSN----LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIP 335
L L+I ED+G Y C + V + P+ L I
Sbjct: 12511 LTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELAAEFISKPQ------NLEIL 12564
Query: 336 WGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL----SRRALRVLSMGPEDEGVYQC 391
G+ A+ C + P V W R+ L S + + +R L V +D G Y
Sbjct: 12565 EGEKAEFVCSISKESFP-VQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVV 12623
Query: 392 MAENEVGSAHAVV--QLRTSRPSITPRLWQDAEL 423
M +AH V +LR P R+ + E+
Sbjct: 12624 MVGAARAAAHLTVIEKLRIVVPLKDTRVKEQQEV 12657
Score = 49.7 bits (117), Expect = 2e-05
Identities = 48/213 (22%), Positives = 93/213 (43%), Gaps = 36/213 (16%)
Query: 487 DSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYE 546
+S +L W E G +PI YV++ R+ + WT + T+ L G Y
Sbjct: 16631 ESCKLTWFSP-EDDGGSPITNYVIEKRESDRRA--WTPVTYTVTRQNATVQGLIQGKAYF 16687
Query: 547 VEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPP 606
+AA N G G P + S+ I+ ++ P
Sbjct: 16688 FRIAAENSIGMG--------------PFVETSEALVIREP----------------ITVP 16717
Query: 607 EAPDRPTISTASETSVYVTWIP-RGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLS 665
E P+ + ++ +V +TW P + +GG I ++ +E + + + + + +
Sbjct: 16718 ERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYT 16777
Query: 666 VEITGLEKGTSYKFRVRALNMLGESEPSAPSRP 698
V+ GL++G +Y++RV A+N++G+ +PS ++P
Sbjct: 16778 VK--GLKEGDTYEYRVSAVNIVGQGKPSFCTKP 16808
Score = 49.3 bits (116), Expect = 2e-05
Identities = 107/500 (21%), Positives = 178/500 (35%), Gaps = 116/500 (23%)
Query: 234 PPE-------AQTIIVTKGQSLILECVASGIPPPRVTWAKDG--SSVTGYNKTRFLLSNL 284
PPE + T+ V G +L ++ SG P P+VT ++DG T T NL
Sbjct: 26473 PPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENL 26532
Query: 285 LIDTTSE--EDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKL 342
I+ D+G Y A N G A + + + PP + +S + +S L
Sbjct: 26533 TINLKESVTADAGRYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDIT---EESVTL 26589
Query: 343 TCEV----RGNPPPSVLWLR--NAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENE 396
E G+ + + L+ + + + ++R ++V+ + +E ++ AEN
Sbjct: 26590 KWEPPKYDGGSQVTNYILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAENR 26649
Query: 397 VGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVG 456
G + + +T +L P T+ G
Sbjct: 26650 FGISDHI-----DSACVTVKL---------------------------------PYTTPG 26671
Query: 457 PASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVT 516
P S P + + R S T + W G A + Y++ K
Sbjct: 26672 PPS--------------TPWVTNVTRESIT----VGWHEPVSNGGSAVVGYHL--EMKDR 26711
Query: 517 NSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIM 576
NS + + +T + G +YE + A N AG G+ + P ++
Sbjct: 26712 NSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPS--------HPSEPVL 26763
Query: 577 ASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTW-IPRGNGGFP 635
A + E P I+ S+ SV ++W P +GG
Sbjct: 26764 A-------------------------IDACEPPRNVRITDISKNSVSLSWQQPAFDGGSK 26798
Query: 636 IQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGE-SEPSA 694
I + VE + L G W A S + I+GL + + Y+FRV A N +G S PS
Sbjct: 26799 ITGYIVERRDLPD-GRWTKA-SFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSE 26856
Query: 695 PSRPYV-VSGYSGRVYERPV 713
P + Y G V + P+
Sbjct: 26857 VVGPITCIDSYGGPVIDLPL 26876
Score = 48.9 bits (115), Expect = 3e-05
Identities = 111/546 (20%), Positives = 182/546 (33%), Gaps = 125/546 (22%)
Query: 169 WLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEA 228
WL+ NY I+ + S+ D ++ A N K S S+ + R A
Sbjct: 28988 WLKC---NYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYA-- 29042
Query: 229 ARIIYPPEAQT--------IIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFL 280
PP+A+ + + G L+L+ G P P++ W K + K
Sbjct: 29043 -----PPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQ 29097
Query: 281 L----SNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPW 336
+ +I DSG Y N G +V+ V+V + P
Sbjct: 29098 YTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVM---VKVLDSP------------- 29141
Query: 337 GQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEG--VYQCMAE 394
G KLT V ++ ++ L+ S+ ED G + + E
Sbjct: 29142 GPCGKLT-----------------VSRVTQEKCTLA------WSLPQEDGGAEITHYIVE 29178
Query: 395 NEVGSAHAVVQLRTSRPS---ITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRP 451
S V + P+ + RL ++ E V+ G P + +P + R
Sbjct: 29179 RRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVP---VESEPIVARN 29235
Query: 452 PTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVK 511
++ P+ P P E G G + ++ + E G I Y+V
Sbjct: 29236 SFTI-PSPPGIPEEVGTG-----------------KEHIIIQWTKPESDGGNEISNYLVD 29277
Query: 512 HRKVTNSSDDWT--ISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVT-FRTG 568
R+ S WT RL +T L G Y+ + A N AG + + + F +
Sbjct: 29278 KRE--KKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISC 29335
Query: 569 RRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWI- 627
R P P P P + ++ S+ + W
Sbjct: 29336 REPS-------------------------------YTPGPPSAPRVVDTTKHSISLAWTK 29364
Query: 628 PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNML 687
P +GG I + +E ++ K W + + L+ G Y FRV A+N+
Sbjct: 29365 PMYDGGTDIVGYVLEMQE-KDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVK 29423
Query: 688 GESEPS 693
G SE S
Sbjct: 29424 GMSEYS 29429
Score = 48.5 bits (114), Expect = 3e-05
Identities = 55/248 (22%), Positives = 95/248 (38%), Gaps = 41/248 (16%)
Query: 601 GRLSPPEAPDRPTISTASETSVYVTWIP-RGNGGFPIQSFRVEYKKLKKVGDWILATSAI 659
GR PP P + + S + ++W P + +GG I ++ +E ++ + W+ +S
Sbjct: 16215 GRPGPPVGPIK--FESVSADQMTLSWFPPKDDGGSKITNYVIEKREANRK-TWVHVSSE- 16270
Query: 660 PPSRLSVEITGLEKGTSYKFRVRALNMLG-----ESEPSAPSRPYVVSGYSGRVYERPVA 714
P + I L +G Y FR+ A N G +SEP + V G
Sbjct: 16271 -PKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPG----------- 16318
Query: 715 GPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDN----DSDYKKDMVEG 770
P +V ++ + W P + +P+ G+++ + T S + D K M G
Sbjct: 16319 APDKPTVSSVTRNSMTVNWEE-PEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMTLG 16377
Query: 771 DKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQ 830
Y ++ L + Y ++ N G S P P +APP
Sbjct: 16378 VSY--KVTGLIEGSDYQFRVYAINAAGVGPAS-----------LPSDPATARDP-IAPPG 16423
Query: 831 PPLPETIE 838
PP P+ +
Sbjct: 16424 PPFPKVTD 16431
Score = 48.1 bits (113), Expect = 5e-05
Identities = 112/539 (20%), Positives = 191/539 (35%), Gaps = 134/539 (24%)
Query: 332 LVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL--SRRALRVLSMGPEDEGVY 389
L++ G S +T RG P P+VLW + L + + SR +L + + D G Y
Sbjct: 26196 LIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKY 26255
Query: 390 QCMAENEVGSAH---AVVQLRTSRP----SITPRLWQDAELATGTPP---VSPSKLGNPE 439
+N + +A V L T P ++ + A L+ P +P K + E
Sbjct: 26256 TLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIE 26315
Query: 440 QMLRGQPALPRPPTSVGPASPQC---------------PGEKGQGAPAEA---------- 474
+ + A + S + E G G PAE
Sbjct: 26316 KREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKP 26375
Query: 475 --PIILSSPRTSKTDSYELVW-RPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQ 531
P L SK DS L W +P H+G R I++YVV+ + +W + +
Sbjct: 26376 SPPEKLGVTSISK-DSVSLTWLKPEHDGGSR--IVHYVVE--ALEKGQKNWVKCAVAKST 26430
Query: 532 HRLTLTRLDPGSLYEVEMAAYNCAG----------------------------------- 556
H + ++ L S Y + A N AG
Sbjct: 26431 HHV-VSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVR 26489
Query: 557 EGQTAMVTFRTGRRPKPEIMASKE-----------QQIQRDDPGASPQSSSQPDHGR--- 602
G V +P P++ S++ +I ++ + + S D GR
Sbjct: 26490 AGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRYEI 26549
Query: 603 -----------------LSPPEAPDRP-TISTASETSVYVTW-IPRGNGGFPIQSFRVEY 643
L P P P IS +E SV + W P+ +GG + ++ +
Sbjct: 26550 TAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNY-ILL 26608
Query: 644 KKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLG-----ESEPSAPSRP 698
K+ W ++ + +R +++ L G Y+FR++A N G +S P
Sbjct: 26609 KRETSTAVWTEVSATV--ARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLP 26666
Query: 699 YVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDS 757
Y G P + P++T V +I + W + P SN + + G+++ + +S
Sbjct: 26667 YTTPG--------PPSTPWVT---NVTRESITVGW-HEPVSNGGSAVVGYHLEMKDRNS 26713
Score = 48.1 bits (113), Expect = 5e-05
Identities = 76/371 (20%), Positives = 139/371 (37%), Gaps = 48/371 (12%)
Query: 65 NVTWRLNGKELNGSDD-ALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVT 123
+V W LNG EL S++ GV + TL I ++ G C+++ G V
Sbjct: 33067 DVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTL 33126
Query: 124 LANLQDFKLDVQHVIE--VDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMP 181
L D + ++EG + C + P ++ + + S N I
Sbjct: 33127 SKELSDAPAFISQPRSQNINEGQNVLFTCEI-SGEPSPEIEWFKNNLPISIS-SNVSISR 33184
Query: 182 SGN---LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYP---- 234
S N L+I NAS D G Y A N Q +A A+ ++ P
Sbjct: 33185 SRNVYSLEIRNASVSDSGKYTIKAKNFRGQ---------------CSATASLMVLPLVEE 33229
Query: 235 PEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNK------TRFLLSNLLIDT 288
P + ++ T G + + +S +++ +K +S + ++ T +++ +
Sbjct: 33230 PSREVVLRTSGDTSLQGSFSS--QSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQS 33287
Query: 289 TS-------EEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAK 341
S E S ++ +++ + + +L PP++ S + I G+
Sbjct: 33288 MSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLT 33347
Query: 342 LTCEVRGNPPPSVLWLRNAVPLISSQRLRL------SRRALRVLSMGPEDEGVYQCMAEN 395
+ C G P P V W + S ++ R L ++ + +D G+Y N
Sbjct: 33348 VACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGN 33407
Query: 396 EVGSAHAVVQL 406
E GS A V +
Sbjct: 33408 EFGSDSATVNI 33418
Score = 47.8 bits (112), Expect = 6e-05
Identities = 142/671 (21%), Positives = 230/671 (34%), Gaps = 187/671 (27%)
Query: 182 SGNLQIVNASQEDEGMYKCAAYNP--VTQEVKTSGSSDR-------LRVRRSTAEAARII 232
S NL ++++ D G Y A NP + + DR L V T+E +
Sbjct: 21516 STNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCVLS 21575
Query: 233 YPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSV--TGYNKTRFLLSNLLIDTTS 290
+ P + G + I + R+ W S V T T+ L N I
Sbjct: 21576 WFPP-----LDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYI---- 21626
Query: 291 EEDSGTYRCMADN--GVGQPGAAVILYNVQVFEPPE-------VTMELSQLVIPWGQ--- 338
+R MA N GVG+P + + V + PP+ T+ +V+ WG
Sbjct: 21627 ------FRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDS 21680
Query: 339 ---SAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAEN 395
S + V W++ ++ R ++S L+ G E E ++ MAEN
Sbjct: 21681 DGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSG-----LTEGHEYE--FRIMAEN 21733
Query: 396 EVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSV 455
G S PS T ++ + P GNP
Sbjct: 21734 AAG---------ISAPSPTSPFYKACDTV-----FKPGPPGNPR---------------- 21763
Query: 456 GPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVW-RPRHEGSGRAPILYYVVKHRK 514
+L + R+S + W +P ++G I Y+V+
Sbjct: 21764 ---------------------VLDTSRSS----ISIAWNKPIYDGGSE--ITGYMVEI-- 21794
Query: 515 VTNSSDDWTISGIPANQHRL--TLTRLDPGSLYEVEMAAYNCAGEGQTAMV--------- 563
D+W I PA T+T L Y++ + A N G G+ A+V
Sbjct: 21795 ALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDR 21854
Query: 564 ----------------TFRT----------GRRPKPEIMASKEQQIQRDDPGASPQSS-- 595
T R RP PE+ +++ D SS
Sbjct: 21855 MLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYT 21914
Query: 596 -------SQPDHGR--------------------LSPPEAPDRPTISTASETSVYVTW-I 627
++ D G+ L P P + ++TSV +TW
Sbjct: 21915 LLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDP 21974
Query: 628 PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNML 687
P +GG I+++ VE ++ + +AT+ + S ++ L++G SY FRV A N
Sbjct: 21975 PLLDGGSKIKNYIVEKRESTRKAYSTVATNC---HKTSWKVDQLQEGCSYYFRVLAENEY 22031
Query: 688 GESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHG 747
G P+ + S + ERP+ IT D V ++ L W P + + I G
Sbjct: 22032 GIGLPAETAE-------SVKASERPLPPGKITLMD-VTRNSVSLSWEK-PEHDGGSRILG 22082
Query: 748 FYIYYRPTDSD 758
+ + + SD
Sbjct: 22083 YIVEMQTKGSD 22093
Score = 47.8 bits (112), Expect = 6e-05
Identities = 46/200 (23%), Positives = 83/200 (41%), Gaps = 15/200 (7%)
Query: 602 RLSPPEAPDRPTISTASETSVYVTWIPR-GNGGFPIQSFRVEYKKLKKVGDWILATSAIP 660
R PPE P + T TA + Y+ W P +GG I + +E ++ ++ W ++ +
Sbjct: 24801 RPGPPEGPLKVTGVTAEKC--YLAWNPPLQDGGANISHYIIEKRETSRLS-WTQVSTEV- 24856
Query: 661 PSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITF 720
L+ ++T L G Y FRV A+N G EP + Y +P P
Sbjct: 24857 -QALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPY------KPPGPPSTPE 24909
Query: 721 TDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHL 780
A+ + ++++ W P + T I G+ + R + + K + + ++ L
Sbjct: 24910 VSAITKDSMVVTWAR-PVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRL--RVTGL 24966
Query: 781 QPETSYDIKMQCFNEGGESE 800
SY+ ++ N G E
Sbjct: 24967 TEGHSYEFRVAAENAAGVGE 24986
Score = 47.8 bits (112), Expect = 6e-05
Identities = 104/481 (21%), Positives = 165/481 (34%), Gaps = 121/481 (25%)
Query: 239 TIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRF----LLSNLLIDTTSEEDS 294
T V + L ++ G P V W KDG ++ + +++L I S+ED
Sbjct: 25403 TFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDV 25462
Query: 295 GTYRCMADNGVGQPGAAVILYNVQVFEPP------EVTMELSQLVIPW------GQSAKL 342
GTY N G + + + PP EV+ + + I W G
Sbjct: 25463 GTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCD--SITISWNPPEYDGGCQIS 25520
Query: 343 TCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHA 402
V S W I SQ ++R +++++ + E ++ AEN G +
Sbjct: 25521 NYIVEKKETTSTTW------HIVSQ--AVARTSIKIVRLTTGSEYQFRVCAENRYGKSS- 25571
Query: 403 VVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQC 462
+ ++ P SP G P G P + S + Q
Sbjct: 25572 ---------------YSESSAVVAEYPFSPP--GPP-----GTPKVVHATKSTMLVTWQV 25609
Query: 463 PGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDW 522
P G S+ Y L ++ R+ IL+ K K+ +
Sbjct: 25610 PVNDG---------------GSRVIGYHLEYKE------RSSILW--SKANKILIADTQM 25646
Query: 523 TISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQ 582
+SG LD G +YE + A N AG G+ +
Sbjct: 25647 KVSG------------LDEGLMYEYRVYAENIAGIGKCS--------------------- 25673
Query: 583 IQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRV 641
S +P R P + P +P ++ + SV + W P +GG I + V
Sbjct: 25674 -----------KSCEPVPAR-DPCDPPGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIV 25721
Query: 642 EYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGE-SEPSAPSRPYV 700
E ++L G W L + E+T L + Y+FRV A N SEPS + P +
Sbjct: 25722 ERRELPD-GRW-LKCNYTNIQETYFEVTELTEDQRYEFRVFARNAADSVSEPSESTGPII 25779
Query: 701 V 701
V
Sbjct: 25780 V 25780
Score = 47.8 bits (112), Expect = 6e-05
Identities = 29/88 (32%), Positives = 45/88 (51%), Gaps = 5/88 (5%)
Query: 238 QTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVT--GYNKTRFLLSNLLIDTTSEEDSG 295
+T+ + G SL L SG PPP +TW+K G + T S L++D + D+G
Sbjct: 29454 KTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAG 29513
Query: 296 TYRCMADNGVGQPGAAVILYNVQVFEPP 323
Y A+N G+ A V+ V+V++ P
Sbjct: 29514 KYTIEAENQSGKKSATVL---VKVYDTP 29538
Score = 47.4 bits (111), Expect = 8e-05
Identities = 52/222 (23%), Positives = 98/222 (44%), Gaps = 26/222 (11%)
Query: 605 PPEAPDRPTISTASETSVYVTW-IPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSR 663
PP P + TA S+ ++W P+ +GG I ++ VE K+ W + ++ + +R
Sbjct: 22243 PPTGPVKMDEVTAD--SITLSWGPPKYDGGSSINNYIVE-KRDTSTTTWQIVSATV--AR 22297
Query: 664 LSVEITGLEKGTSYKFRVRALNMLGE-----SEPSAPSRPYVVSGYSGRVYERPVAGPYI 718
+++ L+ G Y+FR+ A N G+ SEP+ P+ V G P P +
Sbjct: 22298 TTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPG--------PPGTPVV 22349
Query: 719 TFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSIS 778
T + + ++ ++W P S+ + + G+++ + +S K + K+ +
Sbjct: 22350 TLS---SRDSMEVQWNE-PISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKF--KTT 22403
Query: 779 HLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGR 820
L+ Y+ ++ N G + S V C AR PGR
Sbjct: 22404 GLEEGVEYEFRVSAENIVGIGKPSKVSECYV-ARDPCDPPGR 22444
Score = 47.0 bits (110), Expect = 1e-04
Identities = 61/299 (20%), Positives = 113/299 (37%), Gaps = 19/299 (6%)
Query: 36 PQVTVQPASTVQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGS---DDALGVLITHGTL 91
P +P GG+V+ GC V P+ +V W+ +G L + L
Sbjct: 1082 PYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKL 1141
Query: 92 VITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACH 151
VI+ G Y V R G ++ + + A+ + Q ++ + V
Sbjct: 1142 VISMTFADDAGEYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTAFVQEPK 1201
Query: 152 LPESHP-----KAQVRYSVKQEWL--EASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYN 204
+ E+ P + + Y +Q + + ++ ++ Q + S +E + K Y
Sbjct: 1202 VGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYR 1261
Query: 205 PVT---QEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPR 261
+ +E+ +++ V S +EA + + + +G + C SG P P+
Sbjct: 1262 IIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPK 1321
Query: 262 VTWAKDGSSVTGYNKTR--FL---LSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILY 315
+ W KDG + + + FL ++L I ED G Y A N G + LY
Sbjct: 1322 IAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLY 1380
Score = 46.6 bits (109), Expect = 1e-04
Identities = 135/644 (20%), Positives = 230/644 (35%), Gaps = 163/644 (25%)
Query: 236 EAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYN----KTRFLLSNLLIDTTSE 291
E IIV +G+ L + +P P V+W KDG V + K + ++L + +
Sbjct: 14392 ETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVR 14451
Query: 292 EDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPP 351
D+G Y +N +G A++ NV+V P ++ I K +C++ PP
Sbjct: 14452 ADAGIYTITLENKLGSATASI---NVKVIGLPGPCKDIKASDI-----TKSSCKLTWEPP 14503
Query: 352 ------PSVLWL--------RNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEV 397
P + ++ R +P++S + ++ + V + P E ++ A N+V
Sbjct: 14504 EFDGGTPILHYVLERREAGRRTYIPVMSGE----NKLSWTVKDLIPNGEYFFRVKAVNKV 14559
Query: 398 GSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGP 457
G ++L+ P + QD P P P PP V
Sbjct: 14560 GGGE-YIELK------NPVIAQD--------PKQP----------------PDPPVDVEV 14588
Query: 458 ASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTN 517
+P AEA I P P ++G + I+ Y+++ K+
Sbjct: 14589 HNP----------TAEAMTITWKP-------------PLYDGGSK--IMGYIIE--KIAK 14621
Query: 518 SSDDWTISGIPANQHRL-----TLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRT---GR 569
+ W N+H + T L+ G Y+ + A N AG + + T T
Sbjct: 14622 GEERWK----RCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAVDP 14677
Query: 570 RPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPR 629
P+++ +++R D A S S + PTI TWI
Sbjct: 14678 IDAPKVILRTSLEVKRGDEIALDASISGSPY-----------PTI----------TWIKD 14716
Query: 630 GNGGFPIQ-SFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVR------ 682
N P + R ++ G+ + P + I +KG S + RVR
Sbjct: 14717 ENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGES-QLRVRDSLRPD 14775
Query: 683 -ALNMLG-ESEPSAPSRPYVVSGYSGRVYERPVAGPYITFT-DAVNETTIMLKWMYIPAS 739
L M+ E++ P VS V + P GP I F + + +T+++ KW P
Sbjct: 14776 HGLYMIKVENDHGIAKAPCTVS-----VLDTP--GPPINFVFEDIRKTSVLCKW-EPPLD 14827
Query: 740 NNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDI------KMQCF 793
+ + I + + KKD + D W ++ Y + K F
Sbjct: 14828 DGGSEIINYTL------------EKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLF 14875
Query: 794 NEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETI 837
E+ F C +K + G PP P P+ E +
Sbjct: 14876 RVRAENRFGPGPPCVSKPLVAKDPFG--PPDA---PDKPIVEDV 14914
Score = 46.2 bits (108), Expect = 2e-04
Identities = 64/304 (21%), Positives = 123/304 (40%), Gaps = 32/304 (10%)
Query: 31 DLNEVPQVTVQPASTVQKPGGTVILGCVVE-PPRMNVTWRLNGKELNGSDDALGVLITHG 89
+L++ P QP S G V+ C + P + W N ++ S + V I+
Sbjct: 33129 ELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSN---VSISRS 33185
Query: 90 TLVITA-LNNHTV---GRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNT 145
V + + N +V G+Y A+ G ++ + + L +++ + V+ G+T
Sbjct: 33186 RNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEE---PSREVVLRTSGDT 33242
Query: 146 AVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNL-QIVNASQEDEGMYKCAAYN 204
+ L S V+ S ++ EAS ++ + ++ ++ AS + M
Sbjct: 33243 S-----LQGSFSSQSVQMSASKQ--EASFSSFSSSSASSMTEMKFASMSAQSMSSMQESF 33295
Query: 205 PVTQEVKTSGSSDRLRVRRSTAEAARIIY---PPEAQT----IIVTKGQSLILECVASGI 257
G S+ ++ ST++ + PP+ + I + +G+ L + C +G
Sbjct: 33296 VEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGE 33355
Query: 258 PPPRVTWAKDGSSVTGYNKTRFLLSN------LLIDTTSEEDSGTYRCMADNGVGQPGAA 311
P P VTW+ G + + RF + N L+I ++D G Y N G A
Sbjct: 33356 PTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSAT 33415
Query: 312 VILY 315
V ++
Sbjct: 33416 VNIH 33419
Score = 45.8 bits (107), Expect = 2e-04
Identities = 52/186 (27%), Positives = 80/186 (43%), Gaps = 17/186 (9%)
Query: 130 FKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASR--GNYLIMPSGN--L 185
F +Q V+ V EG+TA H+ P +V + + + S G + G L
Sbjct: 8 FTQPLQSVV-VLEGSTATFEAHI-SGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 186 QIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKG 245
I ++ + G Y A N Q T+ L V+ AE A + Q++ V +G
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTA----ELLVK---AETAPPNFVQRLQSMTVRQG 118
Query: 246 QSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFL----LSNLLIDTTSEEDSGTYRCMA 301
+ L+ +GIP P V + +DG+ + + L +LLI EDSGTY A
Sbjct: 119 SQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNA 178
Query: 302 DNGVGQ 307
N VG+
Sbjct: 179 TNSVGR 184
Score = 45.8 bits (107), Expect = 2e-04
Identities = 59/216 (27%), Positives = 87/216 (40%), Gaps = 42/216 (19%)
Query: 490 ELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQH-RLTLTRLDPGSLYEVE 548
+L W P GR PI YV++ ++ + W +G A +T + G+ + +
Sbjct: 14201 DLKWEPPKNDGGR-PIQRYVIEKKERLGTR--WVKAGKTAGPDCNFRVTDVIEGTEVQFQ 14257
Query: 549 MAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEA 608
+ A N AG G + T EI++ +DP SPP
Sbjct: 14258 VRAENEAGVGHPSEPT---------EILSI-------EDP--------------TSPPSP 14287
Query: 609 PDRPTISTASETSVYVTWIP-RGNGGFPIQSFRVEYKKLKKVGD--WILATSA-IPPSRL 664
P ++ A + + W P NGG PI + VE + VG W+ S I +
Sbjct: 14288 PLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVE---MCPVGTEKWMRVNSRPIKDLKF 14344
Query: 665 SVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYV 700
VE G+ Y RVRA+N +G SEPS S V
Sbjct: 14345 KVE-EGVVPDKEYVLRVRAVNAIGVSEPSEISENVV 14379
Score = 45.8 bits (107), Expect = 2e-04
Identities = 50/198 (25%), Positives = 81/198 (40%), Gaps = 13/198 (6%)
Query: 602 RLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPP 661
R PPE P T T SE V + P +GG I + V+ ++ ++ W S +
Sbjct: 21554 RPGPPEGPLAVTEVT-SEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLA-WTNVASEVQV 21611
Query: 662 SRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFT 721
++L V T L KG Y FRV A+N G EP V+ Y P P +T
Sbjct: 21612 TKLKV--TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGP---PDPPKNPEVT-- 21664
Query: 722 DAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQ 781
+ + ++++ W + P S+ + I + + R K + +Y +S L
Sbjct: 21665 -TITKDSMVVCWGH-PDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRY--KVSGLT 21720
Query: 782 PETSYDIKMQCFNEGGES 799
Y+ ++ N G S
Sbjct: 21721 EGHEYEFRIMAENAAGIS 21738
Score = 45.8 bits (107), Expect = 2e-04
Identities = 52/205 (25%), Positives = 91/205 (44%), Gaps = 25/205 (12%)
Query: 602 RLSPPEAPDRPTISTASETSVYVTWIPR-GNGGFPIQSFRVEYKKLKKVGDWILATSAIP 660
R PPE P IS + + W P +GG I ++ VE ++ ++ W + + +
Sbjct: 22636 RPGPPEGP--VVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLV-WTVVDANV- 22691
Query: 661 PSRLSVEITGLEKGTSYKFRVRALNMLG-----ESEPSAPSRPYVVSGYSGRVYERPVAG 715
LS ++T L +G Y FR+ A+N G ESEP P+VV + P A
Sbjct: 22692 -QTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVP-------DAPKA- 22742
Query: 716 PYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWH 775
P +T V + ++++ W PAS+ + I G+ + R + + K ++ +
Sbjct: 22743 PEVT---TVTKDSMIVVWER-PASDGGSEILGYVLEKRDKEGIRWTRCHKRLI--GELRL 22796
Query: 776 SISHLQPETSYDIKMQCFNEGGESE 800
++ L Y+ ++ N G SE
Sbjct: 22797 RVTGLIENHDYEFRVSAENAAGLSE 22821
Score = 45.8 bits (107), Expect = 2e-04
Identities = 28/98 (28%), Positives = 42/98 (42%), Gaps = 6/98 (6%)
Query: 321 EPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISS------QRLRLSRR 374
+ P EL L + + +A L C+V G+P P V W R +I+ Q +
Sbjct: 30926 QAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYH 30985
Query: 375 ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPS 412
L + S+ +D VYQ A N+ GS L P+
Sbjct: 30986 QLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPA 31023
Score = 45.4 bits (106), Expect = 3e-04
Identities = 33/96 (34%), Positives = 45/96 (46%), Gaps = 5/96 (5%)
Query: 606 PEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRL 664
P+ P +S S SV +TW P +GG I ++ VE K W+ A
Sbjct: 31122 PDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVE-KCATTAERWLRVGQARETRYT 31180
Query: 665 SVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYV 700
+ + G TSY+FRV A N G S+PS PS P +
Sbjct: 31181 VINLFGK---TSYQFRVIAENKFGLSKPSEPSEPTI 31213
Score = 44.7 bits (104), Expect = 5e-04
Identities = 29/99 (29%), Positives = 47/99 (47%), Gaps = 6/99 (6%)
Query: 605 PPEAPDRPTISTASETSVYVTWIP-RGNGGFPIQSFRVEYKKLKKVGD----WILATSAI 659
PP+ P + I ++ +V+++W P + +GG P+ + VE G W
Sbjct: 16011 PPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKR- 16069
Query: 660 PPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRP 698
L + L +G Y+FRV+A+N G S+PSA P
Sbjct: 16070 DVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGP 16108
Score = 43.5 bits (101), Expect = 0.001
Identities = 81/366 (22%), Positives = 133/366 (36%), Gaps = 63/366 (17%)
Query: 53 VILGCVVEPPRMNVTWRLNGKELNGSDDALGVLITHG---TLVITALNNHTVGRYQCVAR 109
VIL C + V W +GKE+ S +A V+ G L++ +G+Y C
Sbjct: 12035 VILQCEISKADAPVKWFKDGKEIKPSKNA--VIKADGKKRMLILKKALKSDIGQYTC--- 12089
Query: 110 MPAGAVASVPATVTLANLQDFKLDV---QHVIEVDEGNTAVIACHLPESHPKAQVRYSVK 166
T +++D ++ + H +EV E TA + E A
Sbjct: 12090 -----DCGTDKTSGKLDIEDREIKLVRPLHSVEVMETETARFETEISEDDIHA------- 12137
Query: 167 QEWLEASRGNYLIMPSGNLQIVNASQEDEG------MYKCA--AYNPVTQEVKTSGSSDR 218
N+ + LQ + ++EG ++ C V + SS
Sbjct: 12138 ---------NWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAH 12188
Query: 219 LRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNK-- 276
LRV+ R + + + VT G++ +C S P V W G + +K
Sbjct: 12189 LRVKPRVIGLLRPL-----KDVTVTAGETATFDCELSYEDIP-VEWYLKGKKLEPSDKVV 12242
Query: 277 --TRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPP-EVTMELSQLV 333
+ + L + ED+G + A + N+ V EPP E T L
Sbjct: 12243 PRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHA-------NLFVKEPPVEFTKPLEDQT 12295
Query: 334 IPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSR----RALRVLSMGPEDEGVY 389
+ G +A L CEV V W +N ++ S++ + R L + PED Y
Sbjct: 12296 VEEGATAVLECEV-SRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTY 12354
Query: 390 QCMAEN 395
C A++
Sbjct: 12355 TCDAKD 12360
Score = 43.5 bits (101), Expect = 0.001
Identities = 92/427 (21%), Positives = 160/427 (37%), Gaps = 99/427 (23%)
Query: 240 IIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLID----TTSEEDSG 295
+ + G++ L SG P P+V+W KD + V ++T + + DSG
Sbjct: 16828 LTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSG 16887
Query: 296 TYRCMADNGVGQPGAAVILYNVQVFEPP-------EVTMELSQLVIPW------GQSAKL 342
Y + +N G + V PP EVT + +VI W G S
Sbjct: 16888 KYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKD--YMVISWKPPLDDGGSKIT 16945
Query: 343 TCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHA 402
+ +W+ P+ S+ ++ +V + + +++ AEN G +
Sbjct: 16946 NYIIEKKEVGKDVWM----PVTSAS----AKTTCKVSKLLEGKDYIFRIHAENLYGISDP 16997
Query: 403 VV--------QLRT----SRPSITPRLWQDAELAT------GTPPVSPSKLGNPEQMLRG 444
+V + R +P +T + +D+ L T G P++ L E M +
Sbjct: 16998 LVSDSMKAKDRFRVPDAPDQPIVT-EVTKDSALVTWNKPHDGGKPITNYILEKRETMSKR 17056
Query: 445 QPALPRPP-------------------------TSVGPASPQCPGEKGQGAPAEAPIILS 479
+ + P +G P P + A+ PI
Sbjct: 17057 WARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKP---VFAKDPIAKP 17113
Query: 480 SPRT------SKTDSYELVWR-PRHEGSGRAPILYYVVKHRKVTNSSDDW-----TISGI 527
SP + +S +L W+ PRH+G + IL Y+V+++KV ++W T
Sbjct: 17114 SPPVNPEAIDTTCNSVDLTWQPPRHDGGSK--ILGYIVEYQKV--GDEEWRRANHTPESC 17169
Query: 528 PANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMV---TFRTGRRPKPEIM----ASKE 580
P +++ +T L G Y+ + A N AGE A V R PE++ ++E
Sbjct: 17170 PETKYK--VTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMARE 17227
Query: 581 QQIQRDD 587
Q I+ D
Sbjct: 17228 QHIKVGD 17234
Score = 43.1 bits (100), Expect = 0.001
Identities = 44/202 (21%), Positives = 81/202 (40%), Gaps = 14/202 (6%)
Query: 603 LSPPEAPDRPT-ISTASETSVYVTWIPRGN-GGFPIQSFRVEYKKLKKVGDWILATSAIP 660
L P P P T + + + W P + GG I + VE ++ +V W + + +
Sbjct: 26963 LDKPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRETSRVV-WSMVSEHL- 27020
Query: 661 PSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITF 720
+ T + KG Y FRVRA+N G EP + + V P P +T
Sbjct: 27021 -EECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAF---VTPGPPGIPEVT- 27075
Query: 721 TDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHL 780
+ + ++ + W P ++ + I G+++ R S K+ + + ++ L
Sbjct: 27076 --KITKNSMTVVWSR-PIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTR--QKVTGL 27130
Query: 781 QPETSYDIKMQCFNEGGESEFS 802
+ Y ++ N G+ FS
Sbjct: 27131 TENSDYQYRVCAVNAAGQGPFS 27152
Score = 42.7 bits (99), Expect = 0.002
Identities = 49/180 (27%), Positives = 74/180 (41%), Gaps = 24/180 (13%)
Query: 231 IIYPPEAQTIIVTKGQSLI-LECVASGIPPPRVTWAKDGSSVTGYNKTRF-------LLS 282
I + E Q ++ + ++ EC S P +V W KDG V +K R LS
Sbjct: 2174 ITFTQELQDVVAKEKDTMATFECETSE-PFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLS 2232
Query: 283 NLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKL 342
L IDT+ ED Y C+ A ++ V E EL + +P S +L
Sbjct: 2233 ILTIDTSDAED---YSCVLVEDENVKTTAKLIVEGAVV---EFVKELQDIEVPESYSGEL 2286
Query: 343 TCEVRGNPPPSV--LWLRNAVPLISSQRL----RLSRRALRVLSMGPEDEGVYQCMAENE 396
C V P ++ W N V L S+ + R R+ L V + ED+G Y + + +
Sbjct: 2287 ECIV---SPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGK 2343
Score = 42.7 bits (99), Expect = 0.002
Identities = 104/497 (20%), Positives = 177/497 (35%), Gaps = 112/497 (22%)
Query: 491 LVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMA 550
L W P G + I+ YV++ R + + ++ + T+ L G YE ++
Sbjct: 16735 LTWNPPKYDGG-SEIINYVLESRLI-GTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVS 16792
Query: 551 AYNCAGEGQTAMVT-----------------FR-------------TGR---RPKPEIMA 577
A N G+G+ + T FR TGR +PKP++
Sbjct: 16793 AVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSW 16852
Query: 578 SKEQ-----------------------QIQRDDPG-----ASPQSSSQPDHGRLSPPEAP 609
K++ + +R D G + S+ +++ + P
Sbjct: 16853 FKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVDRP 16912
Query: 610 DRPT--ISTASETSVY--VTWIPR-GNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRL 664
P +S T Y ++W P +GG I ++ +E K++ K W+ TSA ++
Sbjct: 16913 GPPVGPVSFDEVTKDYMVISWKPPLDDGGSKITNYIIEKKEVGK-DVWMPVTSA--SAKT 16969
Query: 665 SVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAV 724
+ +++ L +G Y FR+ A N+ G S+P + RV + P P +T V
Sbjct: 16970 TCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRF--RVPDAP-DQPIVT---EV 17023
Query: 725 NETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPET 784
+ + ++ W + PI + + R T S + KD + + + L
Sbjct: 17024 TKDSALVTWN--KPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFR-VPDLLEGC 17080
Query: 785 SYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIERPVGTG 844
Y+ ++ NE G + S +P P P P PE I+
Sbjct: 17081 QYEFRVSAENEIGIGDPS-----------PPSKPVFAKDPIAKPSPPVNPEAID------ 17123
Query: 845 AMVARSSDLPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALPPSCPYT 904
S DL + GS +L + W + HT P SCP T
Sbjct: 17124 -TTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHT----------PESCPET 17172
Query: 905 MVPLGGLPGHQASGQPY 921
+ GL GQ Y
Sbjct: 17173 KYKVTGL----RDGQTY 17185
Score = 42.4 bits (98), Expect = 0.002
Identities = 47/183 (25%), Positives = 77/183 (42%), Gaps = 19/183 (10%)
Query: 227 EAARIIYPPEAQTIIVTK----GQSLILECVASGIPPPRVT-WAKDGSSVTGYNKTRFLL 281
+A + + E + II+T+ G S I EC+ S P +T W KDGS++ K RF+
Sbjct: 11111 KAVPLKFVKEIKDIILTESEFVGSSAIFECLVS--PSTAITTWMKDGSNIRESPKHRFIA 11168
Query: 282 S----NLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWG 337
L I D+G Y C+ G + + L ++ T+E ++ + G
Sbjct: 11169 DGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLE-EEVTVVKG 11227
Query: 338 QSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLS-----RRALRVLSMGPEDEGVYQCM 392
Q L+CE+ N V+W ++ ++ + RAL + D G Y
Sbjct: 11228 QPLYLSCEL--NKERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVT 11285
Query: 393 AEN 395
EN
Sbjct: 11286 VEN 11288
Score = 42.4 bits (98), Expect = 0.002
Identities = 39/180 (21%), Positives = 75/180 (41%), Gaps = 14/180 (7%)
Query: 169 WLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEA 228
WL+ NY + ++ +++ ++ A N + S S+ + V+ E
Sbjct: 25731 WLKC---NYTNIQETYFEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVK-DDVEP 25786
Query: 229 ARIIYPPEAQTIIVTK-GQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN---- 283
R++ + + +IV K G+ L + +G P P ++WAKDG + +T + ++
Sbjct: 25787 PRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTL 25846
Query: 284 LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLV-----IPWGQ 338
L + D+G Y N G AV + PP +E++ L + WG+
Sbjct: 25847 LTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGR 25906
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/97 (24%), Positives = 50/97 (51%), Gaps = 2/97 (2%)
Query: 603 LSPPEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPP 661
+ PP P + I+ ++++S+ + W P +GG + + VE ++ ++ +W ++
Sbjct: 27164 IDPPGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEE-EWTTVSTKGEV 27222
Query: 662 SRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRP 698
++ L+ G +Y FRV A+N G+ EP + P
Sbjct: 27223 RTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEP 27259
Score = 42.4 bits (98), Expect = 0.002
Identities = 21/82 (25%), Positives = 36/82 (43%), Gaps = 4/82 (4%)
Query: 323 PEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRA----LRV 378
P +T+ + +P GQ+ + V+ P V W N V L S ++ + + L +
Sbjct: 32374 PRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEI 32433
Query: 379 LSMGPEDEGVYQCMAENEVGSA 400
L +D G Y+ + N G A
Sbjct: 32434 LDCHTDDSGTYRAVCTNYKGEA 32455
Score = 42.0 bits (97), Expect = 0.003
Identities = 29/114 (25%), Positives = 52/114 (45%), Gaps = 10/114 (8%)
Query: 297 YRCMADNGVGQPGAAVILYNV---QVFEPPEVTMELS---QLVIPWGQSAKLTCEVRGNP 350
+R A N VG+ + +V + PPEV ++++ + + GQ+ ++ V+G P
Sbjct: 17877 FRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRP 17936
Query: 351 PPSVLWLRNAVPLISSQRL----RLSRRALRVLSMGPEDEGVYQCMAENEVGSA 400
P + W + L+ +R+ L R L++ D G Y A+N G A
Sbjct: 17937 EPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHA 17990
Score = 41.6 bits (96), Expect = 0.004
Identities = 37/161 (22%), Positives = 60/161 (37%), Gaps = 12/161 (7%)
Query: 161 VRYSVK-----QEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGS 215
V YS++ + W+ R N+ + + S D ++ A N V S S
Sbjct: 27887 VGYSIEKRQGNERWV---RCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQS 27943
Query: 216 SDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYN 275
S + R P +I+ G+SL ++ + G P PRVTW KDG +
Sbjct: 27944 SGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRM 28003
Query: 276 KTRFL----LSNLLIDTTSEEDSGTYRCMADNGVGQPGAAV 312
++L + + + G Y A N G A +
Sbjct: 28004 NMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEI 28044
Score = 41.2 bits (95), Expect = 0.006
Identities = 59/285 (20%), Positives = 99/285 (34%), Gaps = 68/285 (23%)
Query: 184 NLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVT 243
+L IV A+ D G + A N + S + + + ++ + + + +
Sbjct: 1514 SLIIVPATPSDSGEWTVVAQNRAGRS-----SISVILTVEAVEHQVKPMFVEKLKNVNIK 1568
Query: 244 KGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN------LLIDTTSEEDSGTY 297
+G L ++ A+G P P + W K+ + + + + L ID+T +DS Y
Sbjct: 1569 EGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWY 1628
Query: 298 RCMADNGVGQPGAAVILYNVQV-FEPPE-----------------VTMELSQLVIPWGQS 339
A N G+ + NV+V F PE EL L + +GQ
Sbjct: 1629 TATAINKAGRDTTRCKV-NVEVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQE 1687
Query: 340 --------------------------------AKLTCEVR--GNPPPSVLWLRNAVPLIS 365
A C + G+P V WL + PL +
Sbjct: 1688 QWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEA 1747
Query: 366 SQRLRLSRR----ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQL 406
+ RLR+ +L D G+ C A N+ G+ H L
Sbjct: 1748 ANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATL 1792
Score = 40.4 bits (93), Expect = 0.009
Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 5/69 (7%)
Query: 337 GQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLS-----RRALRVLSMGPEDEGVYQC 391
G C++ G P P + W ++ + +R ++ R +LR+ + PEDEG+Y
Sbjct: 1305 GMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTA 1364
Query: 392 MAENEVGSA 400
A N G+A
Sbjct: 1365 FASNIKGNA 1373
Score = 40.4 bits (93), Expect = 0.009
Identities = 53/223 (23%), Positives = 81/223 (36%), Gaps = 29/223 (13%)
Query: 93 ITALNNHTVG-RYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACH 151
+ A N VG + V + A S P VTL ++ + +G + V+ +
Sbjct: 24189 VMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLG-Y 24247
Query: 152 LPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVK 211
+ E PK ++S+ E N + S E ++ AYN
Sbjct: 24248 VVEMQPKGTEKWSIVAESKVC-----------NAVVTGLSSGQEYQFRVKAYNE------ 24290
Query: 212 TSGSSDRLRVRRSTAEAARIIYPPEAQ----TIIVTKGQSLILECVASGIPPPRVTWAKD 267
G SD RV A + P + T + G+ L +E G P P ++W KD
Sbjct: 24291 -KGKSDP-RVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKD 24348
Query: 268 G---SSVTGYNKTRFLLSNLL-IDTTSEEDSGTYRCMADNGVG 306
G T N S +L I +++D G Y A N G
Sbjct: 24349 GEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAG 24391
Score = 40.0 bits (92), Expect = 0.012
Identities = 130/607 (21%), Positives = 218/607 (35%), Gaps = 142/607 (23%)
Query: 304 GVGQPGAAVILYNVQVFEPPEVTMELSQ---LVIPWGQSAKLTCEVRGNPPPSVLWL--- 357
G G PG + + EPP V +++S + I G++ ++ V G P P+ +W
Sbjct: 15083 GEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEE 15142
Query: 358 ------RNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRT--- 408
R + + ++ + + ALR +D G Y A N GS A ++
Sbjct: 15143 GELDKDRVVIDNVGTKSELIIKDALR------KDHGRYVITATNSCGSKFAAARVEVFDV 15196
Query: 409 ------SRPSITPRL-----W------------------QDAELATGTPPVSPSKLG-NP 438
+P +T R W +DA++ T P+ + +
Sbjct: 15197 PGPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQPIETERSKCDI 15256
Query: 439 EQMLRGQPALPR----------PPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDS 488
+L GQ R PP +GP P G P + + RT T
Sbjct: 15257 TGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDP----LGPPTSPERLTYTERTKST-- 15310
Query: 489 YELVWR-PRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEV 547
L W+ PR +G +PI Y+++ R+ + D ++ + LD +YE
Sbjct: 15311 ITLDWKEPR--SNGGSPIQGYIIEKRR-HDKPDFERVNKRLCPTTSFLVENLDEHQMYEF 15367
Query: 548 EMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPE 607
+ A N GE + P + + Q P + S + D
Sbjct: 15368 RVKAVNEIGESE-------------PSLPLNVVIQDDEVPPTIKLRLSVRGD-------- 15406
Query: 608 APDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKK----LKKVGDWILAT-SAIPPS 662
TI + V+ IP G P+ ++E+ K ++K D + T + S
Sbjct: 15407 -----TIKVKAGEPVH---IPADVTGLPMP--KIEWSKNETVIEKPTDALQITKEEVSRS 15456
Query: 663 RLSVEIT-----GLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPY 717
E++ +KGT + V A N LG V VY+RP
Sbjct: 15457 EAKTELSIPKAVREDKGT---YTVTASNRLGS----------VFRNVHVEVYDRPSPPRN 15503
Query: 718 ITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSI 777
+ TD + + L W P N + I + I R S +++++ + + I
Sbjct: 15504 LAVTD-IKAESCYLTW-DAPLDNGGSEITHYVIDKRDA-SRKKAEWEEVTNTAVEKRYGI 15560
Query: 778 SHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQ-PGRLPPPTLAPPQPPLPET 836
L P Y+ +++ N+ G S+ E K+ K Q P RLP P P P+
Sbjct: 15561 WKLIPNGQYEFRVRAVNKYGISD-------ECKSDKVVIQDPYRLPGP------PGKPKV 15607
Query: 837 IERPVGT 843
+ R G+
Sbjct: 15608 LARTKGS 15614
Score = 40.0 bits (92), Expect = 0.012
Identities = 44/180 (24%), Positives = 76/180 (42%), Gaps = 37/180 (20%)
Query: 256 GIPPPRVT-WAKD-------------GSSVTGY--------------NKTRFLLSNLLID 287
G P P+VT W K GS VTGY K + + L+
Sbjct: 16423 GPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVV 16482
Query: 288 TTSEEDSG-TYRCMADN--GVGQPGAAVILYNVQV-FEPPEVTMELS---QLVIPWGQSA 340
T +E + +R A N G+G+PG + ++ P++ ++ S ++V+ G
Sbjct: 16483 TGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVI 16542
Query: 341 KLTCEVRGNPPPSVLWLRN--AVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVG 398
++ V G PPP+V W N +P ++ ++ + + +GVY +A+NE G
Sbjct: 16543 RIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAG 16602
Score = 40.0 bits (92), Expect = 0.012
Identities = 34/128 (26%), Positives = 57/128 (44%), Gaps = 10/128 (7%)
Query: 289 TSEEDSGTY--RCMADNGVGQPGAAVILYNVQV---FEPPEVTMELS---QLVIPWGQSA 340
T D TY R +A N G+ A + V V EPPE+ ++ + + I G +
Sbjct: 17177 TGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTL 17236
Query: 341 KLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSR--RALRVLSMGPEDEGVYQCMAENEVG 398
+L+ ++G P P V W + + R+ ++ L + + ED G+Y EN G
Sbjct: 17237 RLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAG 17296
Query: 399 SAHAVVQL 406
S V++
Sbjct: 17297 SKTVSVKV 17304
Score = 39.7 bits (91), Expect = 0.016
Identities = 47/224 (20%), Positives = 74/224 (33%), Gaps = 52/224 (23%)
Query: 234 PPEAQTIIVTKGQSLI--LECV--ASGIPPPRVTWAKDGSSVTGYNKTRFLLS-----NL 284
PP+ + + I L CV +S + VTW KDG + +F S L
Sbjct: 32717 PPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYEL 32776
Query: 285 LIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVF------------------------ 320
I+ +E D G Y C +G G + + Q F
Sbjct: 32777 KINNLTESDQGEYVCEI-SGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTEST 32835
Query: 321 ----------EP----PEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISS 366
EP P + L + AK + G P P+ +W ++ +
Sbjct: 32836 VTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQG 32895
Query: 367 QRLRLSRRA----LRVLSMGPEDEGVYQCMAENEVGSAHAVVQL 406
+ +LS L + D G+Y C +N GS + +L
Sbjct: 32896 GKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKL 32939
Score = 38.9 bits (89), Expect = 0.027
Identities = 61/284 (21%), Positives = 107/284 (37%), Gaps = 35/284 (12%)
Query: 132 LDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQ---IV 188
L+ Q V E D+ AV +C L S KA V++ ++ + Y G++ I
Sbjct: 12829 LEDQTVTEFDD---AVFSCQL--SREKANVKWYRNGREIKEGK-KYKFEKDGSIHRLIIK 12882
Query: 189 NASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSL 248
+ +DE Y C V+ S RL V E II PP Q I+ G +
Sbjct: 12883 DCRLDDECEYACG--------VEDRKSRARLFVEEIPVE---IIRPP--QDILEAPGADV 12929
Query: 249 ILECVASGIPPPRVTWAKDGSSVTGYNKTRFL----LSNLLIDTTSEEDSGTYRCMADNG 304
+ + V W ++ V +K + + + L I D G YR +A +
Sbjct: 12930 VFLAELNK-DKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDK 12988
Query: 305 VGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLI 364
+ +++ P++ LV+ G+ + P W + PL
Sbjct: 12989 EARA-------KLELAAAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLS 13041
Query: 365 SSQ-RLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLR 407
+ + + R+L D+G Y+ + +N+ G A + L+
Sbjct: 13042 TKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLK 13085
Score = 38.5 bits (88), Expect = 0.036
Identities = 36/134 (26%), Positives = 55/134 (41%), Gaps = 15/134 (11%)
Query: 210 VKTSGSSDRLRVRRSTAEAARIIYPPE-------AQTIIVTKGQSLILECVASGIPPPRV 262
V +G SD V R+ PPE A+ + G +L L + G+P P+V
Sbjct: 17192 VNAAGESDPAHVPEPVLVKDRL-EPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKV 17250
Query: 263 TWAKDGSSVTGYNKTRF----LLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQ 318
TW K+ K R + S L I + ED G Y +N G +V + +
Sbjct: 17251 TWKKEDRDAP--TKARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLD 17308
Query: 319 VFEPPEVTMELSQL 332
PP +E+S++
Sbjct: 17309 KPGPPR-DLEVSEI 17321
Score = 38.5 bits (88), Expect = 0.036
Identities = 30/96 (31%), Positives = 42/96 (43%), Gaps = 5/96 (5%)
Query: 606 PEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRL 664
P P + T+ + SV ++W P +GG I + VE + K W +
Sbjct: 22049 PLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQT-KGSDKWATCATV---KVT 22104
Query: 665 SVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYV 700
ITGL +G Y FRV A N G S+P S P +
Sbjct: 22105 EATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVI 22140
Score = 38.1 bits (87), Expect = 0.047
Identities = 28/100 (28%), Positives = 45/100 (45%), Gaps = 12/100 (12%)
Query: 240 IIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN------LLIDTTSEED 293
I + G++L + V +G P P W K+ + +K R ++ N L+I +D
Sbjct: 15114 IQIMAGKTLRIPAVVTGRPVPTKVWTKEEGEL---DKDRVVIDNVGTKSELIIKDALRKD 15170
Query: 294 SGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLV 333
G Y A N G AA V+VF+ P ++L +V
Sbjct: 15171 HGRYVITATNSCGSKFAAA---RVEVFDVPGPVLDLKPVV 15207
Score = 38.1 bits (87), Expect = 0.047
Identities = 35/123 (28%), Positives = 57/123 (46%), Gaps = 19/123 (15%)
Query: 444 GQPALP-RPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWR-PRHEGSG 501
G+P+ P +P ++ P +P PG+ + P + + RTS + L W P EG
Sbjct: 30015 GKPSRPSKPIVAMDPIAP--PGKP------QNPRVTDTTRTSVS----LAWSVPEDEGGS 30062
Query: 502 RAPILYYVVKHRKVTNSSDDWT-ISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQT 560
+ + Y+++ +KV +WT + P TLT L G+ Y + A N G G+
Sbjct: 30063 K--VTGYLIEMQKV--DQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEP 30118
Query: 561 AMV 563
A V
Sbjct: 30119 AEV 30121
Score = 37.7 bits (86), Expect = 0.061
Identities = 47/187 (25%), Positives = 85/187 (45%), Gaps = 25/187 (13%)
Query: 231 IIYPPEAQ-------TIIVTKGQSLILECVASGIPPPRVTWAKDGSSV---TGYN-KTRF 279
I+ PPE + T+I+ G ++ L G PPP++TW+K ++ G + K+
Sbjct: 19687 ILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTD 19746
Query: 280 LLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPP-EVTM-ELSQLVIPWG 337
+ L + ++ D+G Y +N G+ +++ + PP VT+ E+S+
Sbjct: 19747 FDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISK------ 19800
Query: 338 QSAKLTCE---VRGNPP--PSVLWLRNAV-PLISSQRLRLSRRALRVLSMGPEDEGVYQC 391
SA +T E + G P V+ R+A S+ S+ + RV ++ ++
Sbjct: 19801 DSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRV 19860
Query: 392 MAENEVG 398
AENE G
Sbjct: 19861 FAENEYG 19867
Score = 37.4 bits (85), Expect = 0.080
Identities = 62/289 (21%), Positives = 113/289 (39%), Gaps = 36/289 (12%)
Query: 50 GGTVILGCVVEPPRM-NVTWRLNGKE-LNGSDDALGVLITHGTLVITALNNHTVGRYQCV 107
GG ILG VE + + W+ + KE + +G G L T +
Sbjct: 30458 GGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIG-----GLLEATEYEFRVFAENETG 30512
Query: 108 ARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVR-YSVK 166
P S+ +T + +++ V G A ++C + P ++ Y
Sbjct: 30513 LSRPRRTAMSIKTKLTSGEAPGIRKEMKDVT-TKLGEAAQLSCQIV-GRPLPDIKWYRFG 30570
Query: 167 QEWLEASRGNYLIMPSGN---LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRR 223
+E +++ + Y + G L ++ QEDEG+Y C A N V EV+TS +
Sbjct: 30571 KELIQSRK--YKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEV-GEVETSS--------K 30619
Query: 224 STAEAARIIYP--PEAQTIIVTKGQSLILECVASGIPPPRVTW------AKDGSSVTGYN 275
+A +P P + G +L L + G P P +TW ++ ++T N
Sbjct: 30620 LLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIEN 30679
Query: 276 KTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPE 324
T ++ + + +G Y+ N G A + +V++ + P+
Sbjct: 30680 -TEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDA---ILDVEIQDKPD 30724
Score = 37.4 bits (85), Expect = 0.080
Identities = 37/156 (23%), Positives = 58/156 (37%), Gaps = 34/156 (21%)
Query: 185 LQIVNASQEDEGMYKCA-----------------AYNPVTQEVKTSGSSDRLRVRRSTAE 227
L+I N ++ D+G Y C A+ + ++V + + + + +
Sbjct: 32776 LKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTEST 32835
Query: 228 AARIIYP--PE---AQTIIVTKGQSLILEC--------VASGIPPPRVTWAKDGSSVTGY 274
R P PE ++ +IVT Q + A+G P P W KDG ++T
Sbjct: 32836 VTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQG 32895
Query: 275 NKTRFLLSN----LLIDTTSEEDSGTYRCMADNGVG 306
K + L I T DSG Y C N G
Sbjct: 32896 GKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAG 32931
Score = 37.0 bits (84), Expect = 0.10
Identities = 30/108 (27%), Positives = 44/108 (40%), Gaps = 12/108 (11%)
Query: 232 IYPPEAQ-------TIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLS-- 282
I PPE + +++ +L L G P P V W K +T + S
Sbjct: 25102 IEPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFT 25161
Query: 283 NLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELS 330
L+ID + DSG Y +N G A V NV+V + P + L+
Sbjct: 25162 MLVIDNVTRFDSGRYNLTLENNSGSKTAFV---NVRVLDSPSAPVNLT 25206
Score = 36.6 bits (83), Expect = 0.14
Identities = 83/360 (23%), Positives = 146/360 (40%), Gaps = 49/360 (13%)
Query: 116 ASVPATVTLANLQ-DFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASR 174
A A +T+ ++ DF + ++ V V E A C L +A V +S + +++S
Sbjct: 11473 AITTAILTVKEIELDFAVPLKDVT-VPERRQARFECVLTR---EANVIWSKGPDIIKSS- 11527
Query: 175 GNYLIMPSG--NLQIVNASQ-EDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARI 231
+ I+ G ++ ++N SQ +DEG+Y T EV+ +S RL V T +
Sbjct: 11528 DKFDIIADGKKHILVINDSQFDDEGVY--------TAEVEGKKTSARLFV---TGIRLKF 11576
Query: 232 IYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSE 291
+ P E QT V +G++ C S V W K+ + + +LI + +
Sbjct: 11577 MSPLEDQT--VKEGETATFVCELSH-EKMHVVWFKNDAKL-------HTSRTVLISSEGK 11626
Query: 292 EDSGTYRCMADNGVGQPGAAV----ILYNVQVFEP-PEVTMELSQLVIPWGQSAKLTCEV 346
+ + + + Q A V ++V E P T++L L CEV
Sbjct: 11627 THKLEMKEVTLDDISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKTAVEKDEITLKCEV 11686
Query: 347 RGNPPPSVLWLRNAVPLISSQRLRLS----RRALRVLSMGPEDEGVYQCMAENEVGSAHA 402
+ P V W ++ ++ S + + RR L++ +D+G Y C + A+
Sbjct: 11687 SKDVP--VKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANV 11744
Query: 403 VVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQC 462
V+ R + + E+ G +L P+ + GQ L P + ASP C
Sbjct: 11745 TVEARLIK---VEKPLYGVEVFVGETAHFEIELSEPD--VHGQWKLKGQPLT---ASPDC 11796
Score = 36.6 bits (83), Expect = 0.14
Identities = 53/229 (23%), Positives = 91/229 (39%), Gaps = 35/229 (15%)
Query: 615 STASETSVYVTWIP-RGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEK 673
S +++S +TW P +GG PI + +E ++ + +I S ++LS + L
Sbjct: 14489 SDITKSSCKLTWEPPEFDGGTPILHYVLERREAGR-RTYIPVMSG--ENKLSWTVKDLIP 14545
Query: 674 GTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKW 733
Y FRV+A+N +G E P + ++P P + + W
Sbjct: 14546 NGEYFFRVKAVNKVGGGEYIELKNPVIAQD-----PKQPPDPPVDVEVHNPTAEAMTITW 14600
Query: 734 MYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSIS-HLQPETSYDIKMQC 792
P + + I G+ I + + +G++ W + HL P +Y K
Sbjct: 14601 K-PPLYDGGSKIMGYII--------------EKIAKGEERWKRCNEHLVPILTYTAK--G 14643
Query: 793 FNEGGESEFSNVMICETKARKSSG--QPGRLPPPTLAPPQPPLPETIER 839
EG E +F +A ++G +P R PPT A P+ I R
Sbjct: 14644 LEEGKEYQF------RVRAENAAGISEPSRATPPTKAVDPIDAPKVILR 14686
Score = 36.6 bits (83), Expect = 0.14
Identities = 39/150 (26%), Positives = 59/150 (39%), Gaps = 29/150 (19%)
Query: 189 NASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVR----------RSTAE---AARIIYPP 235
N +DE + +CA P E G+ R R++ R AE A I++PP
Sbjct: 17851 NRINKDELIRQCAFRVPGLIE----GNEYRFRIKAANIVGEGEPRELAESVIAKDILHPP 17906
Query: 236 EAQ-------TIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLS----NL 284
E + I V GQ++ + G P P +TW K+G + + + L
Sbjct: 17907 EVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVEL 17966
Query: 285 LIDTTSEEDSGTYRCMADNGVGQ-PGAAVI 313
I D G Y A N G G+A++
Sbjct: 17967 QIKEAVRADHGKYIISAKNSSGHAQGSAIV 17996
Score = 36.6 bits (83), Expect = 0.14
Identities = 26/103 (25%), Positives = 46/103 (44%), Gaps = 8/103 (7%)
Query: 603 LSPPEAPDRPTISTASETSVYVTWIPR-GNGGFPIQSFRVEYKKLKKVGD--WILATSAI 659
+SP + P P + ++ + W P +GG I + +E K+ G+ W+
Sbjct: 27852 VSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIE----KRQGNERWVRCNFT- 27906
Query: 660 PPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVS 702
S +TGL G Y+FR+ A N +G P + S +++
Sbjct: 27907 DVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMT 27949
Score = 35.8 bits (81), Expect = 0.23
Identities = 23/89 (25%), Positives = 39/89 (43%), Gaps = 3/89 (3%)
Query: 321 EPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLS 380
+ P++ + + + G++A+ C V G P P V W N + S+R R+ + L
Sbjct: 1839 QKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLD 1898
Query: 381 M---GPEDEGVYQCMAENEVGSAHAVVQL 406
+ D G + AEN G V+L
Sbjct: 1899 IVDCKSYDTGEVKVTAENPEGVIEHKVKL 1927
Score = 35.8 bits (81), Expect = 0.23
Identities = 23/73 (31%), Positives = 32/73 (43%), Gaps = 2/73 (2%)
Query: 337 GQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL--SRRALRVLSMGPEDEGVYQCMAE 394
G S +L V G PPP + W + + L S + S L V + D G Y AE
Sbjct: 29461 GASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAE 29520
Query: 395 NEVGSAHAVVQLR 407
N+ G A V ++
Sbjct: 29521 NQSGKKSATVLVK 29533
Score = 35.4 bits (80), Expect = 0.30
Identities = 31/113 (27%), Positives = 46/113 (40%), Gaps = 5/113 (4%)
Query: 213 SGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSV- 271
S SSD + E I +T+IV G S + G P P V W+K + +
Sbjct: 26169 SDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLR 26228
Query: 272 -TGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPP 323
Y T ++L I+ + DSG Y N + AA + V+V + P
Sbjct: 26229 TRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVL---SAASLTLVVKVLDTP 26278
Score = 35.4 bits (80), Expect = 0.30
Identities = 25/88 (28%), Positives = 43/88 (48%), Gaps = 3/88 (3%)
Query: 606 PEAPDRPTISTASETSVYVTWI-PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRL 664
P P + + ++++V + W P +GG + + +E K W+ + + P+ L
Sbjct: 29635 PLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAG-TERWMKVVT-LKPTVL 29692
Query: 665 SVEITGLEKGTSYKFRVRALNMLGESEP 692
+T L +G Y FR+RA N G SEP
Sbjct: 29693 EHTVTSLNEGEQYLFRIRAQNEKGVSEP 29720
Score = 34.7 bits (78), Expect = 0.52
Identities = 25/88 (28%), Positives = 37/88 (42%), Gaps = 4/88 (4%)
Query: 240 IIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRF---LLSNLL-IDTTSEEDSG 295
+I G ++ +E G P P VTW K + + F S +L I+ DSG
Sbjct: 21075 VIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSG 21134
Query: 296 TYRCMADNGVGQPGAAVILYNVQVFEPP 323
Y A N VG+ G + + + PP
Sbjct: 21135 PYPLTARNIVGEVGDVITIQVHDIPGPP 21162
Score = 34.3 bits (77), Expect = 0.68
Identities = 27/107 (25%), Positives = 47/107 (43%), Gaps = 10/107 (9%)
Query: 321 EPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISS--QRLRLS----RR 374
+ P T L +V+ G +A + G P P V W R+ + +S +++S R
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 375 ALRVLSMGPEDEGVYQCMAENEVG----SAHAVVQLRTSRPSITPRL 417
L + ++ + G Y A N G +A +V+ T+ P+ RL
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRL 110
Score = 34.3 bits (77), Expect = 0.68
Identities = 39/181 (21%), Positives = 65/181 (35%), Gaps = 40/181 (22%)
Query: 257 IPPPRVT------------WAKD----GSSVTGY---------------NKTRFLLSNLL 285
+PP RVT W K GS +TGY + + L + +
Sbjct: 25297 LPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATIS 25356
Query: 286 IDTTSEEDSGTYRCMADNGVGQP---GAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKL 342
T EE + + G P G VI ++++ P V + + + K+
Sbjct: 25357 GLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEI--KPSVELPFHTFNVKAREQLKI 25414
Query: 343 TCEVRGNPPPSVLWLRNAVPLISSQRLRLSR----RALRVLSMGPEDEGVYQCMAENEVG 398
+G P +V W ++ L + R+ +S +L + ED G Y+ N G
Sbjct: 25415 DVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAG 25474
Query: 399 S 399
S
Sbjct: 25475 S 25475
Score = 33.9 bits (76), Expect = 0.88
Identities = 87/402 (21%), Positives = 152/402 (37%), Gaps = 57/402 (14%)
Query: 25 TAGCFADLNEVPQVTVQPASTVQKPGGTVILGCVVEPPRMNVTWRLNGKELNGSDDALGV 84
T+G L E T A+ T+ L C V P V W +E+ +
Sbjct: 12452 TSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEI--IETGRYE 12509
Query: 85 LITHG---TLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVD 141
++T G LVI + G Y C R+P+ + V + L + +E+
Sbjct: 12510 ILTEGRKRILVIQNAHLEDAGNYNC--RLPS---SRTDGKVKVHELAAEFISKPQNLEIL 12564
Query: 142 EGNTAVIACHL-PESHPKAQVRYSVKQEWLEASRGNYLIMPSGN---LQIVNASQEDEGM 197
EG A C + ES P V++ + LE S Y ++ G L + +A+ +D G
Sbjct: 12565 EGEKAEFVCSISKESFP---VQWKRDDKTLE-SGDKYDVIADGKKRVLVVKDATLQDMGT 12620
Query: 198 YKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGI 257
Y V G++ R + E RI+ P + V + Q ++ C +
Sbjct: 12621 Y-----------VVMVGAA-RAAAHLTVIEKLRIVVP--LKDTRVKEQQEVVFNCEVN-T 12665
Query: 258 PPPRVTWAKDGSSVTGYNK----TRFLLSNLLIDTTSEEDSGTYRCMADNGVGQ--PGAA 311
+ W ++ ++ +K + L+ L I +D Y N G+ AA
Sbjct: 12666 EGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAA 12725
Query: 312 VILY---NVQVFEPPE--VTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNA--VPLI 364
++ ++++ EP + TME + W + +L ++ W +N VP
Sbjct: 12726 NLIVEEEDLRIVEPLKDIETMEKKSVTF-WCKVNRLNVTLK--------WTKNGEEVPFD 12776
Query: 365 S--SQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVV 404
+ S R+ + L + G DEG Y A + A ++
Sbjct: 12777 NRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLI 12818
Score = 33.9 bits (76), Expect = 0.88
Identities = 27/102 (26%), Positives = 44/102 (43%), Gaps = 13/102 (12%)
Query: 239 TIIVTKGQSLILECVASGIPPPRVTWAK---------DGSSVTGYNKTRF-LLSNLLIDT 288
TI V G+ + + +G+P P++ W+K D +T +R + L I
Sbjct: 15407 TIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPK 15466
Query: 289 TSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELS 330
ED GTY A N +G V +V+V++ P L+
Sbjct: 15467 AVREDKGTYTVTASNRLGSVFRNV---HVEVYDRPSPPRNLA 15505
Score = 33.9 bits (76), Expect = 0.88
Identities = 48/227 (21%), Positives = 85/227 (37%), Gaps = 23/227 (10%)
Query: 233 YPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTG----YNKTRFL--LSNLLI 286
+ E + + V + L C +G P P V W + G + Y F L+I
Sbjct: 30930 FKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLII 30989
Query: 287 DTTSEEDSGTYRCMADNGVGQPGAAVILYNVQV---FEPPEVTMELSQLVIPWGQSAKLT 343
+ +++D+ Y+ A N G L V+V P+ + + G+ +
Sbjct: 30990 ASVTDDDATVYQVRATNQGGSVSGTASL-EVEVPAKIHLPKTLEGMGAVHALRGEVVSIK 31048
Query: 344 CEVRGNPPPSVLWLRNAVPLISSQRLR-LSRRALRVL----SMGPEDEGVYQCMAENEVG 398
G P P + W + + ++ + + R+ L + +D G Y A+N G
Sbjct: 31049 IPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFG 31108
Query: 399 SAHAVVQLRTSRPSITPR------LWQDAELATGTPPVSP--SKLGN 437
V+L + PR + +D+ T T P S SK+ N
Sbjct: 31109 IDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITN 31155
Score = 33.5 bits (75), Expect = 1.2
Identities = 20/77 (25%), Positives = 35/77 (45%), Gaps = 2/77 (2%)
Query: 240 IIVTKGQSLILECVASGIPPPRVTWAKDGSSV--TGYNKTRFLLSNLLIDTTSEEDSGTY 297
I+V G + + SG PPP VTW + ++ +T + S+++I G Y
Sbjct: 16534 IVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVY 16593
Query: 298 RCMADNGVGQPGAAVIL 314
+A N G+ +I+
Sbjct: 16594 SLLAKNEAGERKKTIIV 16610
Score = 33.5 bits (75), Expect = 1.2
Identities = 29/109 (26%), Positives = 46/109 (42%), Gaps = 4/109 (3%)
Query: 227 EAARIIYPPEAQTII-VTKGQSLILECVASGIPPPRVTWAKDGSSV--TGYNKTRFLLSN 283
EA I E + II + G SL L G P P V W K + ++
Sbjct: 22938 EAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTS 22997
Query: 284 LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQL 332
L++D + DSG Y +N G A V + + PP V ++++++
Sbjct: 22998 LVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSPP-VNLKVTEI 23045
Score = 32.0 bits (71), Expect = 3.4
Identities = 25/85 (29%), Positives = 35/85 (41%), Gaps = 11/85 (12%)
Query: 245 GQSLILECVASGIPPPRVTWAKDGSS------VTGYNKTRFLLSNLLIDTTSEEDSGTYR 298
G S+ L SG P P + W KD V N T L+++LI +SG Y
Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTD--LASILIKDADRLNSGCYE 26944
Query: 299 CMADNGVGQPGAAVILYNVQVFEPP 323
N +G A + VQ+ + P
Sbjct: 26945 LKLRNAMGSASATI---RVQILDKP 26966
Score = 32.0 bits (71), Expect = 3.4
Identities = 47/216 (21%), Positives = 76/216 (35%), Gaps = 26/216 (12%)
Query: 628 PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNML 687
P +G PI + +E ++ ++ ++ S ++++ G Y+FRV A+N
Sbjct: 28076 PLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLIN---GNEYQFRVSAVNKF 28132
Query: 688 GESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHG 747
G P S P V Y P A P I + +I L W P S+ + I
Sbjct: 28133 GVGRP-LDSDPVVAQ----IQYTVPDA-PGIPEPSNITGNSITLTWAR-PESDGGSEIQQ 28185
Query: 748 FYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMIC 807
+ + R S W + +P + K+ EG E EF ++
Sbjct: 28186 YILERREKKSTR--------------WVKVISKRPISETRFKVTGLTEGNEYEFH--VMA 28229
Query: 808 ETKARKSSGQPGRLPPPTLAPPQPPLPETIERPVGT 843
E A P PP P T+ + T
Sbjct: 28230 ENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDT 28265
Score = 31.2 bits (69), Expect = 5.7
Identities = 23/91 (25%), Positives = 38/91 (41%), Gaps = 6/91 (6%)
Query: 324 EVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRL----SRRALRVL 379
E+ +Q+ I GQ L + G V W+ N V L +S+ R S + L +
Sbjct: 33040 EIKAFSTQMSINEGQRLVLKANIAG--ATDVKWVLNGVELTNSEEYRYGVSGSDQTLTIK 33097
Query: 380 SMGPEDEGVYQCMAENEVGSAHAVVQLRTSR 410
DEG+ C+++ + G L S+
Sbjct: 33098 QASHRDEGILTCISKTKEGIVKCQYDLTLSK 33128
Score = 30.8 bits (68), Expect = 7.5
Identities = 19/80 (23%), Positives = 37/80 (46%), Gaps = 8/80 (10%)
Query: 231 IIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNL----LI 286
++YP + + V +G++ C +G P P+V W +G + + R + ++
Sbjct: 1844 VLYP---EPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLDIV 1900
Query: 287 DTTSEEDSGTYRCMADNGVG 306
D S D+G + A+N G
Sbjct: 1901 DCKS-YDTGEVKVTAENPEG 1919
Score = 30.8 bits (68), Expect = 7.5
Identities = 62/333 (18%), Positives = 114/333 (34%), Gaps = 36/333 (10%)
Query: 48 KPGGTVILGCVVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCV 107
KP GT I C + N+ W E+ + ++ G + + N
Sbjct: 11318 KPKGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEY 11377
Query: 108 ARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQ 167
A G PA +TL + L + + E +A + E+ Q + +K
Sbjct: 11378 AVEIEG--KRYPAKLTLGEREVELLKPIEDVTIYEKESASFDAEISEADIPGQ--WKLKG 11433
Query: 168 EWLEASRGNYLIMPSG----NLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRR 223
E L S + G L V Q E +Y+ A N +T +
Sbjct: 11434 ELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQ--ALNAITTAI------------- 11478
Query: 224 STAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSN 283
T + + + + + V + + ECV + V W+K + +K +
Sbjct: 11479 LTVKEIELDFAVPLKDVTVPERRQARFECVLT--REANVIWSKGPDIIKSSDKFDIIADG 11536
Query: 284 ----LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQS 339
L+I+ + +D G Y + V ++ P L + G++
Sbjct: 11537 KKHILVINDSQFDDEGVYTAEVEGKKTSARLFVTGIRLKFMSP------LEDQTVKEGET 11590
Query: 340 AKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLS 372
A CE+ + V+W +N L +S+ + +S
Sbjct: 11591 ATFVCEL-SHEKMHVVWFKNDAKLHTSRTVLIS 11622
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 120 bits (300), Expect = 9e-27
Identities = 226/1052 (21%), Positives = 361/1052 (34%), Gaps = 194/1052 (18%)
Query: 36 PQVTVQPASTVQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGSDD---ALGVLITHGTL 91
P++ P+ + G L C E P + W G+ + D + +L+ G+L
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 92 VITAL-----NNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTA 146
+ + G Y CVAR G S A++ +A L+D + V G A
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
Query: 147 VIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPV 206
V+ C P HP+ + + L+ + + + G L I + D G Y C N V
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 207
Query: 207 TQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAK 266
G + + E + P + VT S +C A G P P V W K
Sbjct: 208 -------GERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRK 258
Query: 267 DGSSVTGYNKTRFLLSN---LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQV-FEP 322
D + K+R+ + + L I + D G+Y C+A+N VG+ A+ L VQV EP
Sbjct: 259 DDGELP---KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATL-TVQVGSEP 314
Query: 323 PEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNA--------VPLISSQRLRLSRR 374
P ++ V+ G++ CE GNP P++ W R P SS R +S+
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 374
Query: 375 A-LRVLSMGPEDEGVYQCMAENEVGSAHA-----VVQLRTSRPSITPR------------ 416
L + ++ D G Y C N GS V + RP R
Sbjct: 375 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 434
Query: 417 ----------------LW---------QDA---ELATGTPPVSPSKLGNPEQMLRGQPAL 448
LW QD+ +L G + +KLG+ + +
Sbjct: 435 TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGR----YTCI 490
Query: 449 PRPPTSVGPASPQCPGEKGQGAPAEAP------IILSSPRTSKT-----DSYELVWRPRH 497
P+ S ++ G P + P +I S+P + ++ L W+P +
Sbjct: 491 ASTPSGEATWSAYIEVQE-FGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP-N 548
Query: 498 EGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGE 557
SG P Y + + SS W + L P ++Y + A N G
Sbjct: 549 LNSGATPTSYIIEAFSHASGSS--WQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGI 606
Query: 558 GQTAMVTFRTGRRP-KPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTIST 616
+ ++ + P +Q+QR+ A + PT+
Sbjct: 607 SDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHN---------------PTV-- 649
Query: 617 ASETSVYVTWIPRGNGGFPIQSFRVEYKKL---KKVGDWILATSAIPPSRLSVEITGLEK 673
S +S+ V W + IQ +++ Y+ DW L P++ SV I L K
Sbjct: 650 LSSSSIEVHWTVDQQSQY-IQGYKILYRPSGANHGESDW-LVFEVRTPAKNSVVIPDLRK 707
Query: 674 GTSYKFRVRAL--NMLG-----------ESEPSAPSRPYVVSGYSGRVYERPVAGPYITF 720
G +Y+ + R G E PSAP + VS G
Sbjct: 708 GVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDG-------------- 753
Query: 721 TDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYK-KDMVEGDKYWHSISH 779
N T I++ W P N G Y+ N++ Y V+G + I
Sbjct: 754 ----NGTAILVSWQPPPEDTQN----GMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPF 805
Query: 780 LQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIER 839
L P Y +++ G S + A + P + E
Sbjct: 806 LVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN-------------------PVSPED 846
Query: 840 PVGTGAMVARSSDLPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDL-----GFPR 894
V ++ P I G+ G+ II+ L+R K+ T P
Sbjct: 847 QVSLAQQISDVVKQPAFIAGI--GAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPS 904
Query: 895 SALPPSCPY----TMVPLGGLPG----HQASGQPYLSGISGRACANGIHMNRGCPSAAVG 946
P+ Y V GG PG + + QP+L+ N + C +A G
Sbjct: 905 FTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNG 964
Query: 947 YPGMKPQQHC-PGELQQQSDTSSLLRQTHLGN 977
+ P + Q ++ L Q++L N
Sbjct: 965 NSDSNLTTYSRPADWQPTPYATTQLIQSNLSN 996
Score = 46.2 bits (108), Expect = 2e-04
Identities = 37/134 (27%), Positives = 59/134 (44%), Gaps = 17/134 (12%)
Query: 322 PPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLIS------SQRLRLSRRA 375
PP + S L++ G+ A L C+ G P P++ W + + + S R+ L +
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 376 LRVLSM-----GPEDEGVYQCMAENEVGSA---HAVVQLRTSRPSITPRLWQDAELATGT 427
L L + DEGVY C+A N +G A +A +++ R D +A G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP-SDVMVAVGE 146
Query: 428 PPVSPSK--LGNPE 439
P V + G+PE
Sbjct: 147 PAVMECQPPRGHPE 160
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 119 bits (299), Expect = 1e-26
Identities = 124/424 (29%), Positives = 173/424 (40%), Gaps = 53/424 (12%)
Query: 36 PQVTVQPASTVQKPGGTVILGCVV--EPPRMNVTWRLNGKELNGSDDALGVLITHGTLVI 93
PQ+ P TV PG T +L C V E P N+TW + + L S + L +L I
Sbjct: 401 PQLVPAPNVTVS-PGETAVLSCRVLGEAP-YNLTWVRDWRVLPASTGRVAQLADL-SLEI 457
Query: 94 TALNNHTVGRYQCVARMPAGAV-ASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHL 152
+ + GRYQCVA G ASV V A QH +G ++C
Sbjct: 458 SGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHF---SQGVEVKVSCSA 514
Query: 153 PESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPV--TQEV 210
+P + +S + + L+ + + G L I + ED G Y C A N V QE
Sbjct: 515 -SGYPTPHISWSRESQALQEDSRIH-VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQET 572
Query: 211 KTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSS 270
T +D V A ++V G+ +L C ASG+PPPRV W + G
Sbjct: 573 VTLYYTDPPSVSAVNA------------VVLVAVGEEAVLVCEASGVPPPRVIWYRGGLE 620
Query: 271 VTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELS 330
+ L I E D+GTY C A N +G A + L V P++T
Sbjct: 621 MI-LAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL---AVGHAPQLTELPR 676
Query: 331 QLVIPWGQSAKLTCEVRGNPPPSVLWLR-NAVPL---ISSQRLRLSRR----ALRVLSMG 382
+ + G+SA L C G PPP+V W R + PL + + R SR+ L S+
Sbjct: 677 DVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 736
Query: 383 PEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQML 442
PED+ Y C A N G A +L + TG P + ++L
Sbjct: 737 PEDQAPYVCEARNVFGKVQAEARL----------------IVTGHAPPQIASSAPTVRVL 780
Query: 443 RGQP 446
GQP
Sbjct: 781 EGQP 784
Score = 116 bits (291), Expect = 1e-25
Identities = 120/435 (27%), Positives = 169/435 (38%), Gaps = 57/435 (13%)
Query: 32 LNEVPQVTVQPASTVQKPGGTVILGC-VVEPPRMNVTWRLN-----GKELNGSDDALGVL 85
+ PQ+T P + G + +L C P VTWR G L +
Sbjct: 665 VGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQ 724
Query: 86 ITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNT 145
G L ++ Y C AR G V + + + + V EG
Sbjct: 725 PDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQP 784
Query: 146 AVIACHLPESHPKAQVRYSVKQEWLEASR-----GNYLIMPSGNLQIVNASQEDEGMYKC 200
+ C + P + + WL+ R + I G+L + A QE G Y C
Sbjct: 785 VSLPCIVLAGRPLPE------RHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSC 838
Query: 201 AAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPP 260
A N T+GS R V RI P A I +G L CVASG+P P
Sbjct: 839 VATN-------TAGSQHR-DVELVVQVPPRI--HPTATHHITNEGVPASLPCVASGVPAP 888
Query: 261 RVTWAKDGSSVTG----YNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYN 316
+TW K+ +++T YN ++ LLI S +D+G Y C A N VG +
Sbjct: 889 TITWTKETNALTSRGPHYNVSK--EGTLLIAQPSAQDAGAYVCTATNTVGFSSQEM---R 943
Query: 317 VQVFEPPEVTMELS-------QLVIPWGQSAKLTCEVRGNPPPSVLWLRNA--VPLISSQ 367
+ V P + M S Q+ G+ L CE +G+PPP V W +++ VP I+++
Sbjct: 944 LSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNR 1003
Query: 368 RLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAH----AVVQLRTSRPSITPRLWQDAEL 423
L +LR+ + D G Y+C A N GSA VQ RTS WQ L
Sbjct: 1004 YGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTS--------WQPQSL 1055
Query: 424 ATGTPPVSPSKLGNP 438
P S L P
Sbjct: 1056 PVPHHPACLSGLSVP 1070
Score = 114 bits (284), Expect = 7e-25
Identities = 95/342 (27%), Positives = 149/342 (43%), Gaps = 33/342 (9%)
Query: 102 GRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQV 161
G Y+C A AG A + + + + +V V G TAV++C + P
Sbjct: 375 GTYECTAVSRAGT-GRAKAQIVVTDPPPQLVPAPNVT-VSPGETAVLSCRVLGEAP---Y 429
Query: 162 RYSVKQEW--LEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRL 219
+ ++W L AS G + +L+I D G Y+C A N + R
Sbjct: 430 NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN--------ANGVTRA 481
Query: 220 RVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRF 279
V EA ++ +Q ++G + + C ASG P P ++W+++ ++ ++
Sbjct: 482 SVWLLVREAPQVSIHTSSQHF--SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV 539
Query: 280 -LLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQ 338
L+I + ED+G Y C A N VG V LY +PP V+ + +++ G+
Sbjct: 540 DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT---DPPSVSAVNAVVLVAVGE 596
Query: 339 SAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVG 398
A L CE G PPP V+W R + +I + S + LR+ + D G Y C A NE+G
Sbjct: 597 EAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK-LRIPAAQERDAGTYTCRAVNELG 655
Query: 399 SAHAVVQLRTSRP--------SITPRLWQDAEL---ATGTPP 429
A A +QL +T L + A L ATG PP
Sbjct: 656 DASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPP 697
Score = 93.2 bits (230), Expect = 1e-18
Identities = 70/242 (28%), Positives = 111/242 (45%), Gaps = 25/242 (10%)
Query: 182 SGNL--QIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPE--- 236
SGN +I+ AS+ +EG Y+C A + R R+ A+ PP+
Sbjct: 359 SGNSSWEILRASKAEEGTYECTAVS-------------RAGTGRAKAQIVVTDPPPQLVP 405
Query: 237 AQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTS--EEDS 294
A + V+ G++ +L C G P +TW +D + L++L ++ + D
Sbjct: 406 APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDG 465
Query: 295 GTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSV 354
G Y+C+A N G A+V L V E P+V++ S G K++C G P P +
Sbjct: 466 GRYQCVASNANGVTRASVWLL---VREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI 522
Query: 355 LWLRNAVPLISSQRLRL-SRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQL-RTSRPS 412
W R + L R+ + ++ L + + PED G Y C A NEVG+ V L T PS
Sbjct: 523 SWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 582
Query: 413 IT 414
++
Sbjct: 583 VS 584
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,795,770
Number of Sequences: 37866
Number of extensions: 2906148
Number of successful extensions: 23495
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 266
Number of HSP's successfully gapped in prelim test: 421
Number of HSP's that attempted gapping in prelim test: 14836
Number of HSP's gapped (non-prelim): 4984
length of query: 1114
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1001
effective length of database: 13,968,660
effective search space: 13982628660
effective search space used: 13982628660
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.