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Search of human proteins with 15029530
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
(653 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 1329 0.0
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 734 0.0
gi|51317373 netrin-G1 ligand [Homo sapiens] 712 0.0
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 172 9e-43
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 168 1e-41
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 157 2e-38
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 152 9e-37
gi|88702793 slit-like 2 [Homo sapiens] 140 3e-33
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 137 2e-32
gi|153251229 chondroadherin precursor [Homo sapiens] 135 1e-31
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens] 132 1e-30
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 131 2e-30
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 131 2e-30
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 131 2e-30
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 130 4e-30
gi|27363458 leucine rich repeat and fibronectin type III domain ... 130 5e-30
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 129 6e-30
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 129 6e-30
gi|31542244 leucine rich repeat and fibronectin type III domain ... 128 1e-29
gi|198041768 synleurin [Homo sapiens] 128 1e-29
gi|109150416 peroxidasin [Homo sapiens] 127 3e-29
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 125 9e-29
gi|55741571 leucine rich repeat and fibronectin type III domain ... 125 1e-28
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre... 124 4e-28
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec... 124 4e-28
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho... 124 4e-28
gi|194440719 chondroadherin-like [Homo sapiens] 123 5e-28
gi|126517478 peroxidasin homolog-like [Homo sapiens] 122 1e-27
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom... 122 1e-27
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 121 2e-27
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 1329 bits (3440), Expect = 0.0
Identities = 653/653 (100%), Positives = 653/653 (100%)
Query: 1 MKLLWQVTVHHHTWNAILLPFVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVV 60
MKLLWQVTVHHHTWNAILLPFVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVV
Sbjct: 1 MKLLWQVTVHHHTWNAILLPFVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVV 60
Query: 61 CTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFN 120
CTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFN
Sbjct: 61 CTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFN 120
Query: 121 GLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGE 180
GLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGE
Sbjct: 121 GLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGE 180
Query: 181 LKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHG 240
LKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHG
Sbjct: 181 LKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHG 240
Query: 241 LSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHN 300
LSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHN
Sbjct: 241 LSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHN 300
Query: 301 PWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPR 360
PWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPR
Sbjct: 301 PWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPR 360
Query: 361 DLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTG 420
DLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTG
Sbjct: 361 DLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTG 420
Query: 421 VYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTS 480
VYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTS
Sbjct: 421 VYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTS 480
Query: 481 TGYQPAYTTSTTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLA 540
TGYQPAYTTSTTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLA
Sbjct: 481 TGYQPAYTTSTTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLA 540
Query: 541 AAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPT 600
AAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPT
Sbjct: 541 AAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPT 600
Query: 601 IHDHINYNTYKPAHGAHWTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI 653
IHDHINYNTYKPAHGAHWTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI
Sbjct: 601 IHDHINYNTYKPAHGAHWTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI 653
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 734 bits (1895), Expect = 0.0
Identities = 381/672 (56%), Positives = 475/672 (70%), Gaps = 52/672 (7%)
Query: 34 AIAAAASAGPQ---NCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMI 90
A+ +AA G +CP CSCSNQ S+V+CTRR L+EVP IP NTRYLNL EN IQ+I
Sbjct: 42 AVTSAAGGGSPPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVI 101
Query: 91 QADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLR 150
+ DTF+HL HLE+LQL +N +R+IEVGAFNGL SLNTLELFDN LT +P+ AFEYLSKLR
Sbjct: 102 RTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLR 161
Query: 151 ELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKD 210
ELWLRNNPIESIPSYAFNRVPSL RLDLGELK+LEYISE AFEGL NL+YLNLGMCN+KD
Sbjct: 162 ELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKD 221
Query: 211 MPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVE 270
+PNLT LV LEELE+SGN IRPGSF GL+SL+KLW+M++QV+ IERNAFD L SL E
Sbjct: 222 IPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEE 281
Query: 271 LNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCH 330
LNL+HNNL SLPHDLFTPL L +HL+HNPW+C+CD+LWL+WWL+E +P+N+TCC RCH
Sbjct: 282 LNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCH 341
Query: 331 APMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRT-PPMSSVKWLLPNG 389
AP ++GRY+ E+DQ+ F C AP I++ P DLN++EG AELKCRT M+SV WL PNG
Sbjct: 342 APAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWLTPNG 401
Query: 390 TVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAEL--- 446
T+++H S RISVL+DGTLNF++V + DTG YTCMVTN AGN+ ASA LNVS +
Sbjct: 402 TLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAA 461
Query: 447 ------------------NTSNYSFFTTVTVETTEISPEDT------TRKYKPVPTT--- 479
+ Y++FTTVTVET E P + T K P PTT
Sbjct: 462 GGTGSGGGGPGGSGGVGGGSGGYTYFTTVTVETLETQPGEEALQPRGTEKEPPGPTTDGV 521
Query: 480 ------STGYQPAYTTSTTVLIQTTR-VPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGC 532
PA +++T +++R K VP TD T+ LD+VMKTTKIIIGC
Sbjct: 522 WGGGRPGDAAGPASSSTTAPAPRSSRPTEKAFTVPITDVTENALKDLDDVMKTTKIIIGC 581
Query: 533 FVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAAT-----SAAATAAP 587
FVA+T +AA ML+ FYKLRK+HQ RTVEII V++++PAA+ +AAA A+
Sbjct: 582 FVAITFMAAVMLVAFYKLRKQHQLHKHHGPTRTVEIINVEDELPAASAVSVAAAAAVASG 641
Query: 588 SGVSGEGAVVLPTI-HDHINYNTY-KPAHGAHWTENSLGNSL----HPTVTTISEPYIIQ 641
GV G+ + LP + DH+N++ Y A AH++ N G P + +I EP + +
Sbjct: 642 GGVGGDSHLALPALERDHLNHHHYVAAAFKAHYSSNPSGGGCGGKGPPGLNSIHEPLLFK 701
Query: 642 THTKDKVQETQI 653
+ +K+ VQETQI
Sbjct: 702 SGSKENVQETQI 713
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 712 bits (1839), Expect = 0.0
Identities = 356/636 (55%), Positives = 465/636 (73%), Gaps = 28/636 (4%)
Query: 22 VYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLN 81
V L Q+ ++ + A Q CPSVCSCSNQFSKV+C R+ L EVP GI +NTR LN
Sbjct: 29 VLLALQLLVVAGLVRA------QTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLN 82
Query: 82 LMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSG 141
L EN IQ+I+ ++F+HL HLE+LQL RN IR IE+GAFNGLA+LNTLELFDN LT IP+G
Sbjct: 83 LHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNG 142
Query: 142 AFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYL 201
AF YLSKL+ELWLRNNPIESIPSYAFNR+PSL RLDLGELK+L YISEGAFEGL NL+YL
Sbjct: 143 AFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYL 202
Query: 202 NLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNA 261
NL MCN++++PNLTPL+ L+EL++SGNH IRPGSF GL L+KLW++ SQ+ +IERNA
Sbjct: 203 NLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNA 262
Query: 262 FDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPT 321
FD L SLVE+NLAHNNL+ LPHDLFTPL +L +HLHHNPWNC+CDILWL+WW+++ P+
Sbjct: 263 FDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPS 322
Query: 322 NSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCR-TPPMS 380
N+ CC RC+ P +++GRY+ E+DQ F C AP I++ P DLN++EG AELKCR + ++
Sbjct: 323 NTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTSLT 382
Query: 381 SVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLN 440
SV W+ PNGTV++H + RI+VL+DGTLNF++V + DTG+YTCMV+N GN+ ASA LN
Sbjct: 383 SVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLN 442
Query: 441 VSTAELNTSNYSFFTTVTVETTEISPEDT-TRKYKPVPTTSTGYQPAYTTSTTVLIQTTR 499
V+ A T+ +S+F+TVTVET E S ++ T PT ++ T++ T
Sbjct: 443 VTAA--TTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVVDWETTNVTTSLTPQSTRS 500
Query: 500 VPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRST 559
K +P TD + +DEVMKTTKIIIGCFVA+TL+AA ML++FYK+RK+H +++
Sbjct: 501 TEKTFTIPVTDINSGI-PGIDEVMKTTKIIIGCFVAITLMAAVMLVIFYKMRKQHHRQNH 559
Query: 560 VTAARTVEIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPTI-HDHIN-YNTYKPAHGAH 617
RTVEII VD++I T E + +P I H+H+N YN+YK
Sbjct: 560 HAPTRTVEIINVDDEITGDTPM-----------ESHLPMPAIEHEHLNHYNSYKSPFNHT 608
Query: 618 WTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI 653
T N++ NS+H +++ EP +I+ ++KD VQETQI
Sbjct: 609 TTVNTI-NSIH---SSVHEPLLIRMNSKDNVQETQI 640
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 172 bits (436), Expect = 9e-43
Identities = 146/482 (30%), Positives = 206/482 (42%), Gaps = 87/482 (18%)
Query: 45 NCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVL 104
+CP+VC C++Q V+C R L VP G+P +T L+L N + +Q L L+ L
Sbjct: 30 SCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQEL 89
Query: 105 QLGRNSIRQIEVGAFNGLASLNTL------------------------------------ 128
L N + +E GAF+GL SL TL
Sbjct: 90 DLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLD 149
Query: 129 ------------ELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRL 176
E+ DN L + GAF L+KL L L + ++P A R+P+L+ L
Sbjct: 150 GAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVAL 209
Query: 177 ----------------DLGELKKLEY--------ISEGAFEGLFNLKYLNLGMCNIKDMP 212
LG+LK+LE + G+ GL NL L + CN+ +P
Sbjct: 210 RLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGL-NLSSLAITRCNLSSVP 268
Query: 213 --NLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVE 270
L L L L++S N I L L++L + + ++ I +AF GL +
Sbjct: 269 FQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHL 328
Query: 271 LNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCH 330
L++A N L +L F LV L L NP CDC +LWL LR ++ + C
Sbjct: 329 LDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLL-RLRRHLDFGMS-PPACA 386
Query: 331 APMHMRGRYLVE----VDQASFQCSAPFI-MDAPRDLNISEGRMAELKCR--TPPMSSVK 383
P H++G+ L E + F C I PR + EG A C P +V
Sbjct: 387 GPHHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVS 446
Query: 384 WLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVST 443
W+ P+G L A R+ VL DGTL V L D G Y C+V+NVAGN + +L V
Sbjct: 447 WMRPHGAWLGRAG---RVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQ 503
Query: 444 AE 445
E
Sbjct: 504 VE 505
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 168 bits (426), Expect = 1e-41
Identities = 136/478 (28%), Positives = 209/478 (43%), Gaps = 87/478 (18%)
Query: 46 CPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQ 105
CP+ C CS Q V C RR L +P+GIP T+ L+L +N ++ + + F LE +
Sbjct: 28 CPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEID 87
Query: 106 LGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSY 165
L N I +E GAFN L +L +L L N L ++P G F LS L +L + N I + Y
Sbjct: 88 LSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDY 147
Query: 166 AFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMP-----NLTPLVGL 220
F + +L L++G+ L YIS AF GL +L+ L L CN+ +P +L L+ L
Sbjct: 148 MFQDLHNLKSLEVGD-NDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISL 206
Query: 221 EELEMSGNHFP---------------------EIRP-GSFHGLSSLKKLWVMNSQVSLIE 258
++ N+ P ++ P S +GL +L L V N+ +S +
Sbjct: 207 HLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGL-NLTSLSVTNTNLSTVP 265
Query: 259 RNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELH---------------------- 296
AF L L LNL++N +S++ +F+ L L ELH
Sbjct: 266 FLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRV 325
Query: 297 --------------------------LHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCH 330
+++NP CDC +LW+ R+ C
Sbjct: 326 LNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWIL--QRQPTLQFGGQQPMCA 383
Query: 331 APMHMRGRYLVEVDQAS----FQCSAPFIMDAP-RDLNISEGRMAELKCRT--PPMSSVK 383
P +R R + + F C P I + + L + EG+ +L+C P +
Sbjct: 384 GPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVIS 443
Query: 384 WLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNV 441
W+ P ++ S + R +VL DGTL D+G+Y C+ +N AGN +A L V
Sbjct: 444 WVTPRRRFITTKS-NGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 157 bits (398), Expect = 2e-38
Identities = 144/490 (29%), Positives = 196/490 (40%), Gaps = 93/490 (18%)
Query: 36 AAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTF 95
AA AG CP+ C C+ Q V CTRR L+ VP GIP+ TR L L N I+ +
Sbjct: 17 AAPPPAG--GCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDL 74
Query: 96 RHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLR 155
L LE L L N+I +E GAF L L L L N L +IP G F L L L L
Sbjct: 75 AALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLS 134
Query: 156 NNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDM---- 211
N + + Y F + SL RL++G+ L ++S AF GL L+ L L CN+ +
Sbjct: 135 ENKLVILLDYTFQDLHSLRRLEVGD-NDLVFVSRRAFAGLLALEELTLERCNLTALSGES 193
Query: 212 ----------------------PNLTPLVGLEELEMSGNHFP---EIRPGSFHGLSSLKK 246
N L GL LE+ +++P E+ GS GL +L
Sbjct: 194 LGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEI--DNWPLLEEVAAGSLRGL-NLTS 250
Query: 247 LWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHL--------- 297
L V ++ ++ + A A L LNL+HN +S++P F L L ELHL
Sbjct: 251 LSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVE 310
Query: 298 ---------------------------------------HHNPWNCDCDILWLAWWLREY 318
NP CDC +LW+ R
Sbjct: 311 PQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIV--QRRK 368
Query: 319 IPTNSTCCGRCHAPMHMRGRYLVEVDQA----SFQCSAPFIMDAP-RDLNISEGRMAELK 373
C P +RG L + + F C P I + + + + G
Sbjct: 369 TLNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFL 428
Query: 374 CRT--PPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAG 431
CR P +V W+ P ++ A+ R VL GTL D+G YTC+ +N G
Sbjct: 429 CRAEGEPAPTVAWVTPQHRPVT-ATSAGRARVLPGGTLEIQDARPQDSGTYTCVASNAGG 487
Query: 432 NSNASAYLNV 441
N A L V
Sbjct: 488 NDTYFATLTV 497
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 152 bits (384), Expect = 9e-37
Identities = 119/390 (30%), Positives = 188/390 (48%), Gaps = 20/390 (5%)
Query: 66 LSEVPQGI---PSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGL 122
L +P G+ SN L++ EN I ++ F+ L++L+ L++G N + I AF+GL
Sbjct: 131 LKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGL 190
Query: 123 ASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELK 182
SL L L LT IP+ A +L L L LR+ I +I Y+F R+ L L++
Sbjct: 191 NSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWP 250
Query: 183 KLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTP--LVGLEELEMSGNHFPEIRPGSFHG 240
L+ ++ GL NL L++ CN+ +P L LV L L +S N I H
Sbjct: 251 YLDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHE 309
Query: 241 LSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHN 300
L L+++ ++ Q++++E AF GL L LN++ N L++L +F + L L L N
Sbjct: 310 LLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSN 369
Query: 301 PWNCDCDILWL--AWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQA----SFQCSAPF 354
P CDC +LW+ W + TC P ++G+ + F C
Sbjct: 370 PLACDCRLLWVFRRRWRLNFNRQQPTCA----TPEFVQGKEFKDFPDVLLPNYFTCRRAR 425
Query: 355 IMD-APRDLNISEGRMAELKCRT--PPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNF 411
I D + + + EG + CR P ++ WL P ++S A + R++V DGTL
Sbjct: 426 IRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVS-AKSNGRLTVFPDGTLEV 484
Query: 412 SHVLLSDTGVYTCMVTNVAGNSNASAYLNV 441
+ + D G Y C+ N GN + A+L+V
Sbjct: 485 RYAQVQDNGTYLCIAANAGGNDSMPAHLHV 514
Score = 149 bits (376), Expect = 8e-36
Identities = 101/275 (36%), Positives = 144/275 (52%), Gaps = 5/275 (1%)
Query: 30 ILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQM 89
IL + + S CP C CS Q V+C R+ VP+GIP+ TR L+L +N I+
Sbjct: 26 ILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKT 85
Query: 90 IQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKL 149
+ D F HLE L+L N + +E GAFN L +L TL L N L +IP G F LS L
Sbjct: 86 LNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNL 145
Query: 150 RELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIK 209
+L + N I + Y F + +L L++G+ L YIS AF GL +L+ L L CN+
Sbjct: 146 TKLDISENKIVILLDYMFQDLYNLKSLEVGD-NDLVYISHRAFSGLNSLEQLTLEKCNLT 204
Query: 210 DMPN--LTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMN-SQVSLIERNAFDGLA 266
+P L+ L GL L + + IR SF L LK L + + + + N GL
Sbjct: 205 SIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGL- 263
Query: 267 SLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNP 301
+L L++ H NL+++P+ L YL L+L +NP
Sbjct: 264 NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNP 298
>gi|88702793 slit-like 2 [Homo sapiens]
Length = 673
Score = 140 bits (354), Expect = 3e-33
Identities = 110/348 (31%), Positives = 163/348 (46%), Gaps = 29/348 (8%)
Query: 30 ILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQM 89
+L + A G Q CPS C CS Q V CT R + VP+ +P +T L + EN I M
Sbjct: 8 LLPLLLLLALGPGVQGCPSGCQCS-QPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITM 66
Query: 90 IQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKL 149
+ A +F L L++L L +N I + G F LA+L+ L+L N L I + F L +L
Sbjct: 67 LDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRL 126
Query: 150 RELWLRNNPIESIPSYAFN---------------------RVPSLMRLDLGELKKLEYIS 188
L+L N I I AF+ R+P L+ LDL L
Sbjct: 127 ERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNSLLAL-- 184
Query: 189 EGAFEGLFNLKYLNLGMCNIKDMPN--LTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKK 246
E N++ L L ++ + + L L +L++S N + P GL L +
Sbjct: 185 EPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERV-PPVIRGLRGLTR 243
Query: 247 LWVM-NSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCD 305
L + N++++ + GLA+L EL++++ +L +LP DL L L NP+NC
Sbjct: 244 LRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCV 303
Query: 306 CDILWLAWWLRE-YIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSA 352
C + W W+RE ++ S RCH P GR L+E+D A F C A
Sbjct: 304 CPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPA 351
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 137 bits (346), Expect = 2e-32
Identities = 126/439 (28%), Positives = 192/439 (43%), Gaps = 67/439 (15%)
Query: 80 LNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIP 139
L+L N I++I+ TF+ L+ LEVL+L RN+I ++ GAF GL+ ++ L L N L +
Sbjct: 216 LDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVN 275
Query: 140 SGAFEYLSKLRELWLRNNPIESIPS-------------YAFNRVPSLMRLDLGELKKLE- 185
SG+ L+ L +L L NN I I +FN + L L EL L
Sbjct: 276 SGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSV 335
Query: 186 ---------YISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPG 236
+I+EGAF+GL +L+ L+L + E+SG E G
Sbjct: 336 LRLSHNSISHIAEGAFKGLRSLRVLDL-----------------DHNEISGTI--EDTSG 376
Query: 237 SFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELH 296
+F GL SL KL + +++ + + AF GL L LNL N + S+ D F ++ L ELH
Sbjct: 377 AFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELH 436
Query: 297 LHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCS---AP 353
+ + + CDC + WL WL + + C P ++G+ + V SF C P
Sbjct: 437 ISSDSFLCDCQLKWLPPWLIGRM-LQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKP 495
Query: 354 FIMDAPRDLNISEGRMAELKCRTPPMSS----VKWLLPNGTVLSHASRHPRISV-LNDG- 407
I+ P G+ C SS W N VL++A + V DG
Sbjct: 496 QIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDN-EVLTNADMENFVHVHAQDGE 554
Query: 408 ------TLNFSHVLLSDTGVYTCMVTNVAGNS---NASAYLNVSTAELNTSNYSFFTTVT 458
L+ V G Y C++TN G++ A +NV + T + +T
Sbjct: 555 VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPH-----DIT 609
Query: 459 VETTEISPEDTTRKYKPVP 477
+ TT ++ + P P
Sbjct: 610 IRTTTMARLECAATGHPNP 628
Score = 96.3 bits (238), Expect = 8e-20
Identities = 92/325 (28%), Positives = 139/325 (42%), Gaps = 56/325 (17%)
Query: 28 VWILCAAIA-AAASAGPQN-CPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMEN 85
+W+L + A+AGP+ C + C+C+ + C RGL+ +P +PS TR LNL N
Sbjct: 21 LWLLLLRLEPVTAAAGPRAPCAAACTCAGD--SLDCGGRGLAALPGDLPSWTRSLNLSYN 78
Query: 86 NIQMIQADTFRHL-----------------------HHLEVLQLGRNSIRQIEVGAFNGL 122
+ I F L H+ L L N IR +E
Sbjct: 79 KLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAY 138
Query: 123 ASLNTLELFDNWLTVIPS------------------------GAFEYLSK-LRELWLRNN 157
SL L+L N +T + + GAF+ LS+ L L L N
Sbjct: 139 LSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKN 198
Query: 158 PIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPN--LT 215
I +P AF ++P L +LDL ++ I F+GL +L+ L L NI + +
Sbjct: 199 RITQLPVRAF-KLPRLTQLDLNR-NRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFW 256
Query: 216 PLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAH 275
L + L + N E+ GS +GL++L +L + N+ ++ I R + L EL L+
Sbjct: 257 GLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSF 316
Query: 276 NNLSSLPHDLFTPLRYLVELHLHHN 300
NNL+ L + L L L L HN
Sbjct: 317 NNLTRLDEESLAELSSLSVLRLSHN 341
Score = 54.7 bits (130), Expect = 3e-07
Identities = 76/302 (25%), Positives = 117/302 (38%), Gaps = 50/302 (16%)
Query: 353 PFIMDAPRDLNISEGRMAELKCRTP--PMSSVKWLLPNGTVLSHASRHPRISVLNDGTLN 410
P P D+ I MA L+C P + W GT A+R R+ V+ D +
Sbjct: 599 PSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFP-AARERRMHVMPDDDVF 657
Query: 411 F-SHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDT 469
F + V + D GVY+C N AG+ +A+A L V L T + V +E +S +T
Sbjct: 658 FITDVKIDDAGVYSCTAQNSAGSISANATLTV----LETPS----LVVPLEDRVVSVGET 709
Query: 470 -------TRKYKPVPTTSTGYQPAYTTSTTVLI---QTTRVPKQVAVPATDTTDKMQTSL 519
T P T G +P T L Q V VA A T +M +L
Sbjct: 710 VALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTL 769
Query: 520 DEVMKTTKIII----GC--------------FVAVTLLAAAMLIVFYKLRKRHQQRSTVT 561
+++ + GC ++ L + + + Y+ RK+ ++ S
Sbjct: 770 GTERAHSQLSVLPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTN 829
Query: 562 AARTVEIIQVDEDIPAATSAAATAA---PSGVSGEGAVVLPTIHDHINYNTYKPAHGAHW 618
TV V D+P+ S+ T + + V EG P + HI N P +H+
Sbjct: 830 TDETV----VPPDVPSYLSSQGTLSDRQETVVRTEGG---PQANGHIESNGVCPRDASHF 882
Query: 619 TE 620
E
Sbjct: 883 PE 884
>gi|153251229 chondroadherin precursor [Homo sapiens]
Length = 359
Score = 135 bits (340), Expect = 1e-31
Identities = 101/350 (28%), Positives = 165/350 (47%), Gaps = 39/350 (11%)
Query: 31 LCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMI 90
L A + A +A PQNC C + V+C + GL ++P+ + T+ LNL NN ++
Sbjct: 12 LLAGLLPALAACPQNC----HCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVL 66
Query: 91 QADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLR 150
A++FR + +L L L IR++ GAF GL L L L N + V+ +GAF+ L++L
Sbjct: 67 AANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELT 126
Query: 151 ELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYL--------N 202
L+L +N + +P + + +L L L K+ + GAF+G +L++L +
Sbjct: 127 YLYLDHNKVTELPRGLLSPLVNLFILQLNN-NKIRELRAGAFQGAKDLRWLYLSENALSS 185
Query: 203 LGMCNIKDMPN------------------LTPLVGLEELEMSGNHFPEIRPGSFHGLSS- 243
L + D+ N L+ L +EEL++S N I +F
Sbjct: 186 LQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRY 245
Query: 244 LKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWN 303
L+ LW+ N+ + AF G+ +L ++L +N L+ LP + P L L L +NPW
Sbjct: 246 LETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNF--PFDSLETLALTNNPWK 303
Query: 304 CDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAP 353
C C + L WL C +P +G+++ + D A C P
Sbjct: 304 CTCQLRGLRRWLEAKASRPDATCA---SPAKFKGQHIRDTD-AFRSCKFP 349
>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
Length = 716
Score = 132 bits (331), Expect = 1e-30
Identities = 156/686 (22%), Positives = 262/686 (38%), Gaps = 135/686 (19%)
Query: 19 LPFVYLTAQVWILCAAIAAAASAGPQN--CPSVCSCS-----------NQFSKVVCTRRG 65
+ FV Q+ +L + + + QN CP +C C + + V C
Sbjct: 4 MSFVIAACQL-VLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLR 62
Query: 66 LSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASL 125
L+ +P + S+T+ L L NNI D + L +L L +N+ I+ L L
Sbjct: 63 LTRIPSNLSSDTQVLLLQSNNIAKT-VDELQQLFNLTELDFSQNNFTNIKEVGLANLTQL 121
Query: 126 NTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLE 185
TL L +N +T + + LS L+EL++ +N I +I ++AF + +L+RL L KL+
Sbjct: 122 TTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNS-NKLK 180
Query: 186 YISEGAFEGLFNLKYLNLGM--------CNIKDMPNL---------------TPLVGLEE 222
I F+ NL+ L +G N K + NL LVGL+
Sbjct: 181 VIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDS 240
Query: 223 LE---------------------------MSGNHFPEIRPGSFHGLSSLKKLWVMN-SQV 254
LE ++ N +I+ G F + LK+L + N ++
Sbjct: 241 LESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGEL 300
Query: 255 SLIERNAFDGLASLVELN-------------------------LAHNNLSSLPHDLFTPL 289
++R A D L L +L L +N L+++ L
Sbjct: 301 VSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESL 360
Query: 290 RYLVELHLHHNPWNCDCDILWL---AWWLREYIPTNSTCCGRCHAPMHMRGRYLVEV--D 344
L E+ +H NP CDC I W+ +R P + C P +G + EV
Sbjct: 361 PNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCA----MPPEYKGHQVKEVLIQ 416
Query: 345 QASFQCSAPFIMDA-PRDLNISEGRMAELKCR--TPPMSSVKWLLPNGTVLSHASRHPRI 401
+S QC D+ P LN+ G L CR P + W+ P G ++ + +
Sbjct: 417 DSSEQCLPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKY 476
Query: 402 SVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELN-----------TSN 450
+ ++GTL S++ + D+G YTC+ NV G A + V+ L+ T +
Sbjct: 477 KLSSEGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKVNGTLLDGTQVLKIYVKQTES 536
Query: 451 YSFFTT----VTVETTEISPEDTTRKYKPVPTTSTGYQPA-----------YTTSTTVLI 495
+S + V T+ + T K T T P +T V +
Sbjct: 537 HSILVSWKVNSNVMTSNLKWSSATMKIDNPHITYTARVPVDVHEYNLTHLQPSTDYEVCL 596
Query: 496 QTTRVPKQVAVPATDTTDK-----MQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKL 550
+ + +Q + T K + S E ++G AV LA+ + +
Sbjct: 597 TVSNIHQQTQKSCVNVTTKNAAFAVDISDQETSTALAAVMGSMFAVISLASIAVYFAKRF 656
Query: 551 RKRHQQRSTVTAARTVEIIQVDEDIP 576
++++ S + I ++E P
Sbjct: 657 KRKNYHHSLKKYMQKTSSIPLNELYP 682
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 131 bits (330), Expect = 2e-30
Identities = 138/560 (24%), Positives = 221/560 (39%), Gaps = 108/560 (19%)
Query: 45 NCPSVCSCS-----------NQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQAD 93
+CP +C+C + S V C GL P +P+NT+ L L NNI I+
Sbjct: 28 DCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYS 87
Query: 94 T-----------------------FRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLEL 130
T + + L + L N + ++ + L++L L +
Sbjct: 88 TDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYI 147
Query: 131 FDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEG 190
N L+ I GAF L L L L +N ++ I S F+ +P+L L +GE + I +
Sbjct: 148 NHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGE-NPIIRIKDM 206
Query: 191 AFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELE-------------------------- 224
F+ L NL+ L + N+ ++P+ LVGLE LE
Sbjct: 207 NFKPLINLRSLVIAGINLTEIPD-NALVGLENLESISFYDNRLIKVPHVALQKVVNLKFL 265
Query: 225 -MSGNHFPEIRPGSFHGLSSLKKLWV--------------------------MNSQVSLI 257
++ N IR G F + LK+L + N ++S I
Sbjct: 266 DLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYI 325
Query: 258 ERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWL---AWW 314
NAF L L L L N LS+L H L L E+ +H NP CDC I W+
Sbjct: 326 HPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTN 385
Query: 315 LREYIPTNSTCCGRCHAPMHMRGRYLVEVD-QASFQCSAPFIM--DAPRDLNISEGRMAE 371
+R P + C P +G+ + +V + + P I P +LN+ G
Sbjct: 386 IRFMEPDSLFCVD----PPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVS 441
Query: 372 LKCR--TPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNV 429
CR P + W+ P+G L + + V ++GTL+ + V + G+YTC+ TN+
Sbjct: 442 FHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNL 501
Query: 430 AGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYK---PVPTTSTGYQPA 486
G S + V + +N S + ++ +I +K + +S +
Sbjct: 502 VGADLKSVMIKVDGSFPQDNNGS----LNIKIRDIQANSVLVSWKASSKILKSSVKWTAF 557
Query: 487 YTTSTTVLIQTTRVPKQVAV 506
T + Q+ R+P V V
Sbjct: 558 VKTENSHAAQSARIPSDVKV 577
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 131 bits (330), Expect = 2e-30
Identities = 138/560 (24%), Positives = 221/560 (39%), Gaps = 108/560 (19%)
Query: 45 NCPSVCSCS-----------NQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQAD 93
+CP +C+C + S V C GL P +P+NT+ L L NNI I+
Sbjct: 28 DCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYS 87
Query: 94 T-----------------------FRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLEL 130
T + + L + L N + ++ + L++L L +
Sbjct: 88 TDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYI 147
Query: 131 FDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEG 190
N L+ I GAF L L L L +N ++ I S F+ +P+L L +GE + I +
Sbjct: 148 NHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGE-NPIIRIKDM 206
Query: 191 AFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELE-------------------------- 224
F+ L NL+ L + N+ ++P+ LVGLE LE
Sbjct: 207 NFKPLINLRSLVIAGINLTEIPD-NALVGLENLESISFYDNRLIKVPHVALQKVVNLKFL 265
Query: 225 -MSGNHFPEIRPGSFHGLSSLKKLWV--------------------------MNSQVSLI 257
++ N IR G F + LK+L + N ++S I
Sbjct: 266 DLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYI 325
Query: 258 ERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWL---AWW 314
NAF L L L L N LS+L H L L E+ +H NP CDC I W+
Sbjct: 326 HPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTN 385
Query: 315 LREYIPTNSTCCGRCHAPMHMRGRYLVEVD-QASFQCSAPFIM--DAPRDLNISEGRMAE 371
+R P + C P +G+ + +V + + P I P +LN+ G
Sbjct: 386 IRFMEPDSLFCVD----PPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVS 441
Query: 372 LKCR--TPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNV 429
CR P + W+ P+G L + + V ++GTL+ + V + G+YTC+ TN+
Sbjct: 442 FHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNL 501
Query: 430 AGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYK---PVPTTSTGYQPA 486
G S + V + +N S + ++ +I +K + +S +
Sbjct: 502 VGADLKSVMIKVDGSFPQDNNGS----LNIKIRDIQANSVLVSWKASSKILKSSVKWTAF 557
Query: 487 YTTSTTVLIQTTRVPKQVAV 506
T + Q+ R+P V V
Sbjct: 558 VKTENSHAAQSARIPSDVKV 577
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 131 bits (330), Expect = 2e-30
Identities = 138/560 (24%), Positives = 221/560 (39%), Gaps = 108/560 (19%)
Query: 45 NCPSVCSCS-----------NQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQAD 93
+CP +C+C + S V C GL P +P+NT+ L L NNI I+
Sbjct: 28 DCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYS 87
Query: 94 T-----------------------FRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLEL 130
T + + L + L N + ++ + L++L L +
Sbjct: 88 TDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYI 147
Query: 131 FDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEG 190
N L+ I GAF L L L L +N ++ I S F+ +P+L L +GE + I +
Sbjct: 148 NHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGE-NPIIRIKDM 206
Query: 191 AFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELE-------------------------- 224
F+ L NL+ L + N+ ++P+ LVGLE LE
Sbjct: 207 NFKPLINLRSLVIAGINLTEIPD-NALVGLENLESISFYDNRLIKVPHVALQKVVNLKFL 265
Query: 225 -MSGNHFPEIRPGSFHGLSSLKKLWV--------------------------MNSQVSLI 257
++ N IR G F + LK+L + N ++S I
Sbjct: 266 DLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYI 325
Query: 258 ERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWL---AWW 314
NAF L L L L N LS+L H L L E+ +H NP CDC I W+
Sbjct: 326 HPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTN 385
Query: 315 LREYIPTNSTCCGRCHAPMHMRGRYLVEVD-QASFQCSAPFIM--DAPRDLNISEGRMAE 371
+R P + C P +G+ + +V + + P I P +LN+ G
Sbjct: 386 IRFMEPDSLFCVD----PPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVS 441
Query: 372 LKCR--TPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNV 429
CR P + W+ P+G L + + V ++GTL+ + V + G+YTC+ TN+
Sbjct: 442 FHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNL 501
Query: 430 AGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYK---PVPTTSTGYQPA 486
G S + V + +N S + ++ +I +K + +S +
Sbjct: 502 VGADLKSVMIKVDGSFPQDNNGS----LNIKIRDIQANSVLVSWKASSKILKSSVKWTAF 557
Query: 487 YTTSTTVLIQTTRVPKQVAV 506
T + Q+ R+P V V
Sbjct: 558 VKTENSHAAQSARIPSDVKV 577
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 130 bits (327), Expect = 4e-30
Identities = 131/454 (28%), Positives = 206/454 (45%), Gaps = 36/454 (7%)
Query: 53 SNQFSKVVCTRRGLSEVPQGIPS--NTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNS 110
S+ V R +S +P I + ++L L N I++++ TF+ L L L++ RN
Sbjct: 191 SSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNG 250
Query: 111 IRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRV 170
I +++ GAF GL ++ LEL N LT + G L L++L++ N IE I A+
Sbjct: 251 ISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFC 310
Query: 171 PSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPN--LTPLVGLEELEMSGN 228
L LDL +L + E AF GL L+ LNLG + + + L L+ L++ N
Sbjct: 311 QRLSELDL-SYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNN 369
Query: 229 HFP---EIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDL 285
E +F GL+SL KL + +Q+ I + AF GL SL L+L +N + S+ +
Sbjct: 370 EISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENA 429
Query: 286 FTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQ 345
F+ +L EL L+ + CDC + WL WL + +S C P + G+ ++ VD
Sbjct: 430 FSQ-THLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVS-CAHPEWLAGQSILNVDL 487
Query: 346 ASFQCS---APFIMDAPRDLNISEGRMAELKCRT-----PPMSSVKWLLPNGTVLSHASR 397
F C P I P + G L C PMS+V W + +L
Sbjct: 488 KDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTV-W-RKDSEILYDVDT 545
Query: 398 HPRI--------SVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTS 449
+ ++ L+ +V +D G Y C+VTN G SN S ++ E+
Sbjct: 546 ENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFG-SNYSQKAKLTVNEMP-- 602
Query: 450 NYSFFTT---VTVETTEISPEDTTRKYKPVPTTS 480
SF T +T+ T ++ + + P P S
Sbjct: 603 --SFLKTPMDLTIRTGAMARLECAAEGHPAPQIS 634
Score = 85.9 bits (211), Expect = 1e-16
Identities = 87/329 (26%), Positives = 142/329 (43%), Gaps = 56/329 (17%)
Query: 24 LTAQVWILCAAIAAAASAGPQNCPSVCSC------------------------------- 52
L+ ++I A+ +AG CP+ CSC
Sbjct: 21 LSRLLFIAQTALLLLPAAGAGLCPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAIL 80
Query: 53 ---------------SNQFSKVVCTRRGLSEVPQ-GIP-SNTRYLNLMENNIQMIQADTF 95
S +V L+E+P G P SN L+L+ N I I A
Sbjct: 81 DFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQAL 140
Query: 96 RHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYL-SKLRELWL 154
+ LE L L N I +I+ +F + L L L +N +T + +G F+ L S L + L
Sbjct: 141 QFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSSSLLVVKL 199
Query: 155 RNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNL---GMCNIKDM 211
N + IP F ++P L L+L + +++ + F+GL +L+ L + G+ +KD
Sbjct: 200 NRNRMSMIPPKIF-KLPHLQFLEL-KRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKD- 256
Query: 212 PNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVEL 271
L +EELE+ N+ + G +GL L++L+V + + I +A++ L EL
Sbjct: 257 GAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSEL 316
Query: 272 NLAHNNLSSLPHDLFTPLRYLVELHLHHN 300
+L++N L+ L F L L L+L N
Sbjct: 317 DLSYNQLTRLDESAFVGLSLLERLNLGDN 345
Score = 55.5 bits (132), Expect = 2e-07
Identities = 71/299 (23%), Positives = 120/299 (40%), Gaps = 50/299 (16%)
Query: 353 PFIMDAPRDLNISEGRMAELKCRTP--PMSSVKWLLPNGTVLSHASRHPRISVLNDGTLN 410
P + P DL I G MA L+C P + W GT A+R R+ V+ + +
Sbjct: 602 PSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFP-AARERRMHVMPEDDVF 660
Query: 411 F-SHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEI----- 464
F ++V + D G+Y+CM N AG +A+A L V T ET +
Sbjct: 661 FIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAG 720
Query: 465 -SPE---DTTRKYKPVPTTSTGYQPA-----------------YTTSTTVLIQTTRVPKQ 503
SP + T+ P+ T + A YT + + T R
Sbjct: 721 GSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIY 780
Query: 504 VAVPATDTTDKMQTSL---DEVMKTTKIII----GCFVAVTLLAAAMLIVFYKLRKRHQQ 556
+ V ++ D Q+S+ D+ T I+I C V +L+ +IV Y +R++++
Sbjct: 781 LNVISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGTSLI---WVIVIYHMRRKNED 837
Query: 557 RSTVTAARTVEIIQVDEDIPAATSAAATAA------PSGVSGEGAVVLPTIHDHINYNT 609
S E + + DIP+ S+ T + + +G ++P + +I+ T
Sbjct: 838 YSIT----NTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPANGYIHKGT 892
>gi|27363458 leucine rich repeat and fibronectin type III domain
containing 4 [Homo sapiens]
Length = 635
Score = 130 bits (326), Expect = 5e-30
Identities = 115/409 (28%), Positives = 176/409 (43%), Gaps = 58/409 (14%)
Query: 40 SAGPQNCPSVCSCSN--QFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRH 97
++G CP C C N + +C RGL VP + T L L +N IQ + FR+
Sbjct: 11 ASGAAACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQALGPPDFRN 70
Query: 98 LHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNN 157
+ L L L RN+I +I AF L SL +L L N L + +G+ L+ L L N
Sbjct: 71 MTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPVNLQHLILSGN 130
Query: 158 PIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEG-LFNLKYLNLGMCNIKDMP--NL 214
+L I+ GAF+ L +L+ L+L N++ +P +
Sbjct: 131 -------------------------QLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGI 165
Query: 215 TPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLA 274
+ L L + N + PG+F L L +L + +++++ LA
Sbjct: 166 GAMPALHTLNLDHNLIDALPPGAFAQLGQLSRLDLTSNRLA----------------TLA 209
Query: 275 HNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMH 334
+ L S D LV L NP +C+C++LWL R P + C +P
Sbjct: 210 PDPLFSRGRDAEASPAPLV-LSFSGNPLHCNCELLWLRRLAR---PDDLETCA---SPPG 262
Query: 335 MRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRT--PPMSSVKWLLPNGTVL 392
+ GRY V + F C P I + L + EG+ A L+CR P ++ W+ P+ ++
Sbjct: 263 LAGRYFWAVPEGEFSCEPPLIARHTQRLWVLEGQRATLRCRALGDPAPTMHWVGPDDRLV 322
Query: 393 SHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNV 441
++S R +GTL D G YTC+ TN AG + A L V
Sbjct: 323 GNSS---RARAFPNGTLEIGVTGAGDAGGYTCIATNPAGEATARVELRV 368
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 129 bits (325), Expect = 6e-30
Identities = 94/297 (31%), Positives = 141/297 (47%), Gaps = 28/297 (9%)
Query: 30 ILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQM 89
+L A A CPS C+CS S+V CT + VP +P N L ++ +I
Sbjct: 15 LLVGCQAWGAGLAYHGCPSECTCSRA-SQVECTGARIVAVPTPLPWNAMSLQILNTHITE 73
Query: 90 IQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYL--- 146
+ F ++ L L++ +N + +I GAF L SL L L +N L V+P G F+ L
Sbjct: 74 LNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSL 133
Query: 147 ---------------------SKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLE 185
S L+EL L N +E IP AF+ + L +L+LG+ L
Sbjct: 134 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGK-NSLT 192
Query: 186 YISEGAFEGLFNLKYLNLGMCNIKDMP--NLTPLVGLEELEMSGNHFPEIRPGSFHGLSS 243
+IS F+ L NL+ L L + D+P LV L+EL + N + PG FH +
Sbjct: 193 HISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHN 252
Query: 244 LKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHN 300
L++L++ N+ +S + + F L L L L N+L L +F P+ L EL L+ N
Sbjct: 253 LQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 309
Score = 129 bits (323), Expect = 1e-29
Identities = 94/292 (32%), Positives = 147/292 (50%), Gaps = 28/292 (9%)
Query: 80 LNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIP 139
LNL +N++ I F+HL +L+VL+L N + I +G F+GL +L L L N + ++
Sbjct: 184 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLS 243
Query: 140 SGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLK 199
G F L+ L+L NN I +P F ++P L RL L L+ +S G F + NL+
Sbjct: 244 PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFG-NSLKELSLGIFGPMPNLR 302
Query: 200 YLNLGMCNIKDMPN--LTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLI 257
L L +I +P+ + L L+ L +S N I PG+F+GL+ L++L + + + +
Sbjct: 303 ELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDL 362
Query: 258 ERNAFDGLASLVELNLAHNNLSSLPHDLFT------------------------PLRYLV 293
+ N F LA+L ++L +N L LP ++F L L
Sbjct: 363 DGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLC 422
Query: 294 ELHLHHNPWNCDCDILWLAWWLREYIPTNST-CCGRCHAPMHMRGRYLVEVD 344
EL L+ NPW CD DIL L WL P T C +P ++RG+ L+ ++
Sbjct: 423 ELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIIN 474
Score = 75.1 bits (183), Expect = 2e-13
Identities = 54/160 (33%), Positives = 77/160 (48%), Gaps = 4/160 (2%)
Query: 47 PSVCSCSNQFSKVVCTRRGLSEVPQGI---PSNTRYLNLMENNIQMIQADTFRHLHHLEV 103
PS+ Q +++ L E+ GI N R L L +N+I + + F +L L+V
Sbjct: 268 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 327
Query: 104 LQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIP 163
L L RN I I GAFNGL L L L N L + F L+ L+ + L+NN + +P
Sbjct: 328 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLP 387
Query: 164 SYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNL 203
F V LM + L + +LE + G F+ L L L L
Sbjct: 388 GNIFANVNGLMAIQL-QNNQLENLPLGIFDHLGKLCELRL 426
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 129 bits (325), Expect = 6e-30
Identities = 94/297 (31%), Positives = 141/297 (47%), Gaps = 28/297 (9%)
Query: 30 ILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQM 89
+L A A CPS C+CS S+V CT + VP +P N L ++ +I
Sbjct: 9 LLVGCQAWGAGLAYHGCPSECTCSRA-SQVECTGARIVAVPTPLPWNAMSLQILNTHITE 67
Query: 90 IQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYL--- 146
+ F ++ L L++ +N + +I GAF L SL L L +N L V+P G F+ L
Sbjct: 68 LNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSL 127
Query: 147 ---------------------SKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLE 185
S L+EL L N +E IP AF+ + L +L+LG+ L
Sbjct: 128 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGK-NSLT 186
Query: 186 YISEGAFEGLFNLKYLNLGMCNIKDMP--NLTPLVGLEELEMSGNHFPEIRPGSFHGLSS 243
+IS F+ L NL+ L L + D+P LV L+EL + N + PG FH +
Sbjct: 187 HISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHN 246
Query: 244 LKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHN 300
L++L++ N+ +S + + F L L L L N+L L +F P+ L EL L+ N
Sbjct: 247 LQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 303
Score = 129 bits (323), Expect = 1e-29
Identities = 94/292 (32%), Positives = 147/292 (50%), Gaps = 28/292 (9%)
Query: 80 LNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIP 139
LNL +N++ I F+HL +L+VL+L N + I +G F+GL +L L L N + ++
Sbjct: 178 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLS 237
Query: 140 SGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLK 199
G F L+ L+L NN I +P F ++P L RL L L+ +S G F + NL+
Sbjct: 238 PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFG-NSLKELSLGIFGPMPNLR 296
Query: 200 YLNLGMCNIKDMPN--LTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLI 257
L L +I +P+ + L L+ L +S N I PG+F+GL+ L++L + + + +
Sbjct: 297 ELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDL 356
Query: 258 ERNAFDGLASLVELNLAHNNLSSLPHDLFT------------------------PLRYLV 293
+ N F LA+L ++L +N L LP ++F L L
Sbjct: 357 DGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLC 416
Query: 294 ELHLHHNPWNCDCDILWLAWWLREYIPTNST-CCGRCHAPMHMRGRYLVEVD 344
EL L+ NPW CD DIL L WL P T C +P ++RG+ L+ ++
Sbjct: 417 ELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIIN 468
Score = 75.1 bits (183), Expect = 2e-13
Identities = 54/160 (33%), Positives = 77/160 (48%), Gaps = 4/160 (2%)
Query: 47 PSVCSCSNQFSKVVCTRRGLSEVPQGI---PSNTRYLNLMENNIQMIQADTFRHLHHLEV 103
PS+ Q +++ L E+ GI N R L L +N+I + + F +L L+V
Sbjct: 262 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 321
Query: 104 LQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIP 163
L L RN I I GAFNGL L L L N L + F L+ L+ + L+NN + +P
Sbjct: 322 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLP 381
Query: 164 SYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNL 203
F V LM + L + +LE + G F+ L L L L
Sbjct: 382 GNIFANVNGLMAIQL-QNNQLENLPLGIFDHLGKLCELRL 420
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 128 bits (322), Expect = 1e-29
Identities = 114/438 (26%), Positives = 184/438 (42%), Gaps = 73/438 (16%)
Query: 29 WILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQ 88
++ IA A P+ C VC + +C ++GL VP I T L L +N +
Sbjct: 7 YLFLIGIAVKAQICPKRC--VCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVT 64
Query: 89 MIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSK 148
I+ F ++ SL L L N ++ I AF L
Sbjct: 65 NIKRKDFANM------------------------TSLVDLTLSRNTISFITPHAFADLRN 100
Query: 149 LRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNI 208
LR L L +N + I + F+ + +L L L +L IS AF+ +F
Sbjct: 101 LRALHLNSNRLTKITNDMFSGLSNLHHLILNN-NQLTLISSTAFDDVF------------ 147
Query: 209 KDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASL 268
LEEL++S N+ I + + SL L + ++ + I + F L +
Sbjct: 148 ----------ALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKM 197
Query: 269 VELNLAHNNLSSLPHD-LFTPLRYLVE----------LHLHHNPWNCDCDILWLAWWLRE 317
L++ N L LP D LF + L L NP +C+C++LWL RE
Sbjct: 198 TRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSRE 257
Query: 318 YIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKC--R 375
C +P + GRY + + F C P I ++ + EG+ A L+C R
Sbjct: 258 ------DDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKAR 311
Query: 376 TPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNA 435
P ++ W+ P G ++S+A+R V ++GTL+ + DTG +TC+ +N AG +
Sbjct: 312 GDPEPAIHWISPEGKLISNATRS---LVYDNGTLDILITTVKDTGAFTCIASNPAGEATQ 368
Query: 436 SAYLNVSTAE--LNTSNY 451
L++ LN++N+
Sbjct: 369 IVDLHIIKLPHLLNSTNH 386
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 128 bits (322), Expect = 1e-29
Identities = 107/371 (28%), Positives = 156/371 (42%), Gaps = 82/371 (22%)
Query: 46 CPSVCS-CSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLH----- 99
C SVC C+ + ++ C GLS +P+ P +T +L L NNI I LH
Sbjct: 32 CSSVCQLCTGR--QINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVAL 89
Query: 100 -------------------HLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPS 140
HL L L N I++++ G F GL +L L L N ++ +P
Sbjct: 90 YLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPR 149
Query: 141 GAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKY 200
G F L ++ L L+ N + + S F + +L LDL L ISE F+ L NL
Sbjct: 150 GVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILR-ISESGFQHLENLAC 208
Query: 201 LNLGMCNIKDMPN--LTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIE 258
L LG N+ +P+ L L L +S N I+P +F GL++L+ L + NS++ +
Sbjct: 209 LYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVT 268
Query: 259 RNAFDGLASLVELNLAHNNLSSLPHDLFT------------------------------- 287
R+ F G+ +L L L+HN+L +L D F+
Sbjct: 269 RDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLK 328
Query: 288 ------------------PLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRC 329
PL L+ L + NPW C+C +L L WL T + C
Sbjct: 329 ILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITLNI---YC 385
Query: 330 HAPMHMRGRYL 340
P MRGR L
Sbjct: 386 QNPPSMRGRAL 396
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 127 bits (319), Expect = 3e-29
Identities = 93/316 (29%), Positives = 146/316 (46%), Gaps = 23/316 (7%)
Query: 159 IESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPN--LTP 216
+E++P+ A P LDL ++ I GAF L NL L L IK +P+
Sbjct: 54 LEAVPAVA----PQTSILDL-RFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFED 108
Query: 217 LVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHN 276
L L+ L + N I +F GL+SL++L++ +Q+ ++ ++F L L L L +N
Sbjct: 109 LENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNN 168
Query: 277 NLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPT-NSTCCGRCHAPMHM 335
++ L F L + L L N +CDC+ILWLA L+ Y + N+ C P +
Sbjct: 169 RITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRI 228
Query: 336 RGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRTP--PMSSVKWLLPNGTVLS 393
+GR + + C P I P+D +++ G CR P + WL N +
Sbjct: 229 QGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNEL-- 286
Query: 394 HASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSF 453
R+++L+DGTL + +D G+Y CM NVAG V T E+ +
Sbjct: 287 SMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAG--------EVKTQEV---TLRY 335
Query: 454 FTTVTVETTEISPEDT 469
F + T I P++T
Sbjct: 336 FGSPARPTFVIQPQNT 351
Score = 87.8 bits (216), Expect = 3e-17
Identities = 115/467 (24%), Positives = 171/467 (36%), Gaps = 113/467 (24%)
Query: 29 WILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQ 88
W A +A AG CPS C C + V C L VP P +
Sbjct: 22 WGTLAVVAQKPGAG---CPSRCLCFR--TTVRCMHLLLEAVPAVAPQTS----------- 65
Query: 89 MIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSK 148
+L L N IR+I+ GAF L +LNTL L +N + IPSGAFE L
Sbjct: 66 --------------ILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLEN 111
Query: 149 LRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNI 208
L+ L+L N I+SI AF + SL +L YL+
Sbjct: 112 LKYLYLYKNEIQSIDRQAFKGLASLEQL-----------------------YLHFNQIET 148
Query: 209 KDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKL--------------WVM---- 250
D + L LE L + N + PG+F+ L S+K+L W+
Sbjct: 149 LDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLK 208
Query: 251 ------NSQVSLI----ERNAFDGLASLV--ELNLAHNNLSSLPHDLFTPLRYLVELHLH 298
N+Q + I R +A++ ELN ++S P D V
Sbjct: 209 TYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCR 268
Query: 299 HNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSA------ 352
N +I+WL + T+S + ++ E DQ +QC A
Sbjct: 269 AEG-NPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQ--ETDQGIYQCMAKNVAGE 325
Query: 353 ----------------PFIMDAPRDLNISEGRMAELKCRTP--PMSSVKWLLPNGTVLSH 394
P + P++ + G L+C P + W + T L
Sbjct: 326 VKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPV 385
Query: 395 ASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNV 441
PR+++ G L +V+ D+G Y C TN + +A+A++ V
Sbjct: 386 ---DPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIV 429
Score = 46.2 bits (108), Expect = 9e-05
Identities = 35/122 (28%), Positives = 51/122 (41%), Gaps = 24/122 (19%)
Query: 340 LVEVDQASFQCSAPFIMDA------------------PRDLNISEGRMAELKCRTP--PM 379
+V+ D + CSA +D+ P+D + EG+ + +C P
Sbjct: 402 VVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPP 461
Query: 380 SSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYL 439
+ W G+ LS RH VL+ GTL S V L D G Y C N+ G+ A+L
Sbjct: 462 PVIAWT-KGGSQLSVDRRH---LVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHL 517
Query: 440 NV 441
V
Sbjct: 518 TV 519
Score = 39.7 bits (91), Expect = 0.009
Identities = 26/110 (23%), Positives = 45/110 (40%), Gaps = 6/110 (5%)
Query: 353 PFIMDAPRDLNISEGRMAELKCRTP--PMSSVKWLLPNGTVLSHASRHPRISVLNDGTLN 410
P P D + G +L C + P ++ W V H + +G L
Sbjct: 525 PVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFH----ISPEGFLT 580
Query: 411 FSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVE 460
+ V +D G Y C+ N G+++ S L+V+ +++ + F T VE
Sbjct: 581 INDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVE 630
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 125 bits (315), Expect = 9e-29
Identities = 86/314 (27%), Positives = 146/314 (46%), Gaps = 30/314 (9%)
Query: 66 LSEVPQGIPSNT---RYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGL 122
L +P+G+ + L+L N +Q + F+ L HL+ L L +N + Q+ F+ L
Sbjct: 133 LEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPL 192
Query: 123 ASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELK 182
SL TL+L +N L+ +P G F L L+EL+L +N I +P F+++ L RL L +
Sbjct: 193 TSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWL-QRN 251
Query: 183 KLEYISEGAFEGLFNLKYLNLGMCNIKDMP--------------------------NLTP 216
+ ++ F L NL +L+L ++ +P
Sbjct: 252 AITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAH 311
Query: 217 LVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHN 276
L L L +S N + G F L L KL++ ++ ++ + F L+ L L+L+ N
Sbjct: 312 LSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKN 371
Query: 277 NLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMR 336
L++LP +F L L LH NPW CDC + +L WL++Y C P +++
Sbjct: 372 QLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLK 431
Query: 337 GRYLVEVDQASFQC 350
G+ + +++ C
Sbjct: 432 GQVVPALNEKQLVC 445
Score = 56.2 bits (134), Expect = 9e-08
Identities = 38/117 (32%), Positives = 59/117 (50%), Gaps = 1/117 (0%)
Query: 184 LEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSS 243
LE + G+ L + +LN +C + L LE+LE++G+ F + F L+S
Sbjct: 64 LETRAFGSNPNLTKVVFLNTQLCQFRP-DAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTS 122
Query: 244 LKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHN 300
L KL + + + + F LA+L L+L N L +LP LF PL +L L+L N
Sbjct: 123 LGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQN 179
Score = 53.9 bits (128), Expect = 5e-07
Identities = 68/272 (25%), Positives = 101/272 (37%), Gaps = 74/272 (27%)
Query: 29 WILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQ 88
W+L ++ A Q CP C C Q +V C+ L+ VP IP T+ + +E
Sbjct: 6 WLLWTSLLLLARPA-QPCPMGCDCFVQ--EVFCSDEELATVPLDIPPYTKNIIFVET--- 59
Query: 89 MIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSK 148
S +E AF +L + + L AF L +
Sbjct: 60 ---------------------SFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPR 98
Query: 149 LRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNI 208
L +L + + ++ + F+ + S LG+L LN M
Sbjct: 99 LEDLEVTGSSFLNLSTNIFSNLTS-----LGKLT------------------LNFNM--- 132
Query: 209 KDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASL 268
LE L PE G F L++L+ L + +Q+ + R F L L
Sbjct: 133 -----------LEAL-------PE---GLFQHLAALESLHLQGNQLQALPRRLFQPLTHL 171
Query: 269 VELNLAHNNLSSLPHDLFTPLRYLVELHLHHN 300
LNLA N L+ LP +LF PL L L L +N
Sbjct: 172 KTLNLAQNLLAQLPEELFHPLTSLQTLKLSNN 203
>gi|55741571 leucine rich repeat and fibronectin type III domain
containing 2 [Homo sapiens]
Length = 789
Score = 125 bits (314), Expect = 1e-28
Identities = 109/407 (26%), Positives = 174/407 (42%), Gaps = 54/407 (13%)
Query: 46 CPSVCSCSNQFSKV--VCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEV 103
CP C C N + +C +GL VP I T L L N I I F ++ L
Sbjct: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
Query: 104 LQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIP 163
L L RN+I I+ +F L SL +L L N L + L L+ L + NN + I
Sbjct: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
Query: 164 SYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMP--NLTPLVGLE 221
AF + L L+ L+L N+ +P ++ +V L
Sbjct: 141 DEAFE------------------------DFLLTLEDLDLSYNNLHGLPWDSVRRMVNLH 176
Query: 222 ELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSL 281
+L + N I G+F L L +L + ++++ + + A + S+L
Sbjct: 177 QLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPI----------FARSQASAL 226
Query: 282 PHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLV 341
F P + NP +C+C++LWL R+ + CG +P ++GRY
Sbjct: 227 TATPFAP---PLSFSFGGNPLHCNCELLWLRRLERD---DDLETCG---SPGGLKGRYFW 277
Query: 342 EVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRT--PPMSSVKWLLPNGTVLSHASRHP 399
V + F C P I L + EG+ A LKC+ P + W+ P+ ++ ++S
Sbjct: 278 HVREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSS--- 334
Query: 400 RISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAEL 446
R +V ++GTL+ D+G +TC+ N AG A+A + VS +L
Sbjct: 335 RTAVYDNGTLDIFITTSQDSGAFTCIAANAAG--EATAMVEVSIVQL 379
>gi|38202222 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 124 bits (310), Expect = 4e-28
Identities = 142/558 (25%), Positives = 237/558 (42%), Gaps = 74/558 (13%)
Query: 37 AAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQ-------- 88
A S ++CPSVC C F + C R L+ +P GIP + L L N I
Sbjct: 22 APLSVMAKSCPSVCRCDAGF--IYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDL 79
Query: 89 --MIQADTFRHLH------------HLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNW 134
+++ + H +++ L L N+IR I + + + L L L DN
Sbjct: 80 KNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNS 139
Query: 135 LTV--IPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAF 192
++ I GAF + LR L+L N + +IP + R +RLD ++ IS +
Sbjct: 140 VSAVSIEEGAFRDSNYLRLLFLSRNHLSTIP-WGLPRTIEELRLDDN---RISTISSPSL 195
Query: 193 EGLFNLKYLNL--GMCNIKDMPNLT--PLVGLEELEMSGNHF---PEIRPGSFHGLSSLK 245
+GL +LK L L + N + + LV L EL + N P PG+ +L+
Sbjct: 196 QGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGT-----NLR 250
Query: 246 KLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCD 305
KL++ ++ ++ + NAF L L L++++NNLS+LP +F L + +L L +NPW C
Sbjct: 251 KLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCG 310
Query: 306 CDILWLAWWLREYIPTNSTCCG-RCHAPMHMRGRYLVEVDQASFQCSAPFIMDA------ 358
C + W+ WL+ +P G C AP +RG + +++ F C I+
Sbjct: 311 CKMKWVRDWLQS-LPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITTA 369
Query: 359 -PRDLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISV--LNDGTLNFSHVL 415
P + ++G+ + P + + K + T S + + I+V + T++ S L
Sbjct: 370 IPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTSDTIHISWKL 429
Query: 416 -LSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYK 474
L T + + G+S A + + S Y T + P+ +
Sbjct: 430 ALPMTALRLSWLK--LGHSPAFGSITETIVTGERSEYL--------VTALEPDSPYKVCM 479
Query: 475 PVPTTSTGYQPAYTTSTTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKI----II 530
TS Y T V I+T P ++ P T + + E K + II
Sbjct: 480 VPMETSNLY---LFDETPVCIETETAPLRMYNPTTTLNREQE---KEPYKNPNLPLAAII 533
Query: 531 GCFVAVTLLAAAMLIVFY 548
G VA+ +A L+ +Y
Sbjct: 534 GGAVALVTIALLALVCWY 551
>gi|7019383 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 124 bits (310), Expect = 4e-28
Identities = 142/558 (25%), Positives = 237/558 (42%), Gaps = 74/558 (13%)
Query: 37 AAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQ-------- 88
A S ++CPSVC C F + C R L+ +P GIP + L L N I
Sbjct: 22 APLSVMAKSCPSVCRCDAGF--IYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDL 79
Query: 89 --MIQADTFRHLH------------HLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNW 134
+++ + H +++ L L N+IR I + + + L L L DN
Sbjct: 80 KNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNS 139
Query: 135 LTV--IPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAF 192
++ I GAF + LR L+L N + +IP + R +RLD ++ IS +
Sbjct: 140 VSAVSIEEGAFRDSNYLRLLFLSRNHLSTIP-WGLPRTIEELRLDDN---RISTISSPSL 195
Query: 193 EGLFNLKYLNL--GMCNIKDMPNLT--PLVGLEELEMSGNHF---PEIRPGSFHGLSSLK 245
+GL +LK L L + N + + LV L EL + N P PG+ +L+
Sbjct: 196 QGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGT-----NLR 250
Query: 246 KLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCD 305
KL++ ++ ++ + NAF L L L++++NNLS+LP +F L + +L L +NPW C
Sbjct: 251 KLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCG 310
Query: 306 CDILWLAWWLREYIPTNSTCCG-RCHAPMHMRGRYLVEVDQASFQCSAPFIMDA------ 358
C + W+ WL+ +P G C AP +RG + +++ F C I+
Sbjct: 311 CKMKWVRDWLQS-LPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITTA 369
Query: 359 -PRDLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISV--LNDGTLNFSHVL 415
P + ++G+ + P + + K + T S + + I+V + T++ S L
Sbjct: 370 IPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTSDTIHISWKL 429
Query: 416 -LSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYK 474
L T + + G+S A + + S Y T + P+ +
Sbjct: 430 ALPMTALRLSWLK--LGHSPAFGSITETIVTGERSEYL--------VTALEPDSPYKVCM 479
Query: 475 PVPTTSTGYQPAYTTSTTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKI----II 530
TS Y T V I+T P ++ P T + + E K + II
Sbjct: 480 VPMETSNLY---LFDETPVCIETETAPLRMYNPTTTLNREQE---KEPYKNPNLPLAAII 533
Query: 531 GCFVAVTLLAAAMLIVFY 548
G VA+ +A L+ +Y
Sbjct: 534 GGAVALVTIALLALVCWY 551
>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
sapiens]
Length = 674
Score = 124 bits (310), Expect = 4e-28
Identities = 122/470 (25%), Positives = 190/470 (40%), Gaps = 107/470 (22%)
Query: 7 VTVHHHTWNAILLPFVYLTAQV-----------WI-LCAAIAAAASA--GPQNCPSVCSC 52
+ V H T A P +TA V W+ LC + A + CPSVC C
Sbjct: 1 MVVAHPTATATTTPTATVTATVVMTTATMDLRDWLFLCYGLIAFLTEVIDSTTCPSVCRC 60
Query: 53 SNQFSKVVCTRRGLSEVPQGIPSNT----------------------------------- 77
N F + C RGL+ +P IP +
Sbjct: 61 DNGF--IYCNDRGLTSIPADIPDDATTLYLQNNQINNAGIPQDLKTKVNVQVIYLYENDL 118
Query: 78 -----------RYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIR--QIEVGAFNGLAS 124
R L+L +NN++ I D+ + LE L L NS+ IE AF
Sbjct: 119 DEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQ 178
Query: 125 LNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDL-GELKK 183
L L L N L+ IPSG L +LR L +N I +IP +AF + SL RL L G L
Sbjct: 179 LKLLFLSRNHLSSIPSGLPHTLEELR---LDDNRISTIPLHAFKGLNSLRRLVLDGNLLA 235
Query: 184 LEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSS 243
+ I++ F L NL L+L ++ P L + H
Sbjct: 236 NQRIADDTFSRLQNLTELSLVRNSLAAPP----------LNLPSAH-------------- 271
Query: 244 LKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWN 303
L+KL++ ++ +S I N + L L+L++NNL++LP LF L L +L L +NPW
Sbjct: 272 LQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWF 331
Query: 304 CDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQC--SAPFIMDAPRD 361
C C+++WL W++ + C P +RG + ++ +C + P
Sbjct: 332 CGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGMAIKDITSEMDECFETGP-------- 383
Query: 362 LNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNF 411
+G +A +T + P G++ + ++ P + L D +++
Sbjct: 384 ----QGGVANAAAKTTASNHASATTPQGSLFTLKAKRPGLR-LPDSNIDY 428
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 123 bits (309), Expect = 5e-28
Identities = 101/320 (31%), Positives = 143/320 (44%), Gaps = 32/320 (10%)
Query: 46 CPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQ 105
CP C C + C GL VP+G PS+T+ L+L N+ + F L HL L
Sbjct: 396 CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLH 455
Query: 106 LGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSY 165
L I ++E GA GL L L L DN L + + A E +L L+L N +P
Sbjct: 456 LQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGA 515
Query: 166 AFNRVPSLMRL-------------DLGELKKLEY----------ISEGAFEGLFNLKYLN 202
A +PSL L DLG + L + +S GA L+ L+
Sbjct: 516 ALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLH 575
Query: 203 LGMCNIKDMPN--LTPLVGLEELEMSGNHFPEIRPGSFHGLS-SLKKLWVMNSQVSLIER 259
L ++++P L L L EL++SGN +R G+F + SL+ L++ +S + I
Sbjct: 576 LDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICP 635
Query: 260 NAFDGLA-SLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREY 318
AF GL L L+L N L +LP L L + L NP++CDC +L L WL
Sbjct: 636 GAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQLELIDLSSNPFHCDCQLLPLHRWL--- 690
Query: 319 IPTNSTCCGRCHAPMHMRGR 338
N C P + RG+
Sbjct: 691 TGLNLRVGATCATPPNARGQ 710
Score = 115 bits (288), Expect = 1e-25
Identities = 101/347 (29%), Positives = 143/347 (41%), Gaps = 42/347 (12%)
Query: 35 IAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADT 94
+A A A Q CP C C N V C + L+EVP IP T+ L+L N +++I A
Sbjct: 22 LAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAA 81
Query: 95 FRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWL 154
F+ + HL L L + + GAF GL L L L N L +P A + L LR L L
Sbjct: 82 FQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLEL 141
Query: 155 RNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNL----------- 203
N +E + F + +L L+L L Y+ AF+GL +++L L
Sbjct: 142 EGNALEELRPGTFGALGALATLNLAH-NALVYLPAMAFQGLLRVRWLRLSHNALSVLAPE 200
Query: 204 ---GMCNIKDM------------PNLTPLVGLEELEMSGNHFPEIRPGSFHGLS--SLKK 246
G+ ++ + P L+ GL LE+ H P G GL+ L++
Sbjct: 201 ALAGLPALRRLSLHHNELQALPGPVLSQARGLARLEL--GHNPLTYAGEEDGLALPGLRE 258
Query: 247 LWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLR---YLVELHLHHNPWN 303
L + + + AF L L+L N L +LP PL+ L L L NP
Sbjct: 259 LLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP-----PLQGPGQLRRLRLQGNPLW 313
Query: 304 CDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQC 350
C C L WL G C P +RG L + +C
Sbjct: 314 CGCQARPLLEWLAR---ARVRSDGACQGPRRLRGEALDALRPWDLRC 357
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 122 bits (306), Expect = 1e-27
Identities = 92/294 (31%), Positives = 128/294 (43%), Gaps = 29/294 (9%)
Query: 154 LRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPN 213
LR N I IP AF ++ +L L L + IS AFEGL NL YL L I +
Sbjct: 57 LRFNRIREIPGSAFKKLKNLNTLLLNN-NHIRKISRNAFEGLENLLYLYLYKNEIHALDK 115
Query: 214 LTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNL 273
T F GL SL+ L++ +Q+ +++ F L L L L
Sbjct: 116 QT----------------------FKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFL 153
Query: 274 AHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNST-CCGRCHAP 332
+N LS +P F+ L L L L N CDCD++WL L+ + T C P
Sbjct: 154 HNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYP 213
Query: 333 MHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRTP--PMSSVKWLLPNGT 390
+ GR + V F C +P I P+D+ + G CR P + W+ N +
Sbjct: 214 RRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHS 273
Query: 391 VLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNA-SAYLNVST 443
+ R++V +DGTL + SD GVY CM N AG + SA L S+
Sbjct: 274 L--DLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSS 325
Score = 67.4 bits (163), Expect = 4e-11
Identities = 51/157 (32%), Positives = 69/157 (43%), Gaps = 27/157 (17%)
Query: 46 CPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQ 105
CPS C C S V C L +PQ +P T L+L N I+ I F+ L +L L
Sbjct: 24 CPSRCLCFK--STVRCMHLMLDHIPQ-VPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLL 80
Query: 106 LGRNSIRQIEVGAFNGLASLNTLELFDN------------------------WLTVIPSG 141
L N IR+I AF GL +L L L+ N L ++
Sbjct: 81 LNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPE 140
Query: 142 AFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDL 178
F L +L L+L NN + IP+ +F+ + SL RL L
Sbjct: 141 TFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRL 177
>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
sapiens]
Length = 660
Score = 122 bits (305), Expect = 1e-27
Identities = 108/355 (30%), Positives = 146/355 (41%), Gaps = 80/355 (22%)
Query: 46 CPSVCSCSNQFSKVVCTRRGLSEVPQGIPS------------------------------ 75
CPSVC C F V C R L+ VP GIP
Sbjct: 36 CPSVCRCDRNF--VYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTV 93
Query: 76 ----------------NTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEV--G 117
N R L+L ENNIQ I L LE L L NSI + V G
Sbjct: 94 YLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDG 153
Query: 118 AFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLD 177
AF SL L L N L+ +P G L +LR + N I I AF + SL RL
Sbjct: 154 AFREAISLKLLFLSKNHLSSVPVGLPVDLQELR---VDENRIAVISDMAFQNLTSLERLI 210
Query: 178 L-GELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPG 236
+ G L + I+EG F L LK ++ + S +H P PG
Sbjct: 211 VDGNLLTNKGIAEGTFSHLTKLKEFSI-------------------VRNSLSHPPPDLPG 251
Query: 237 SFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELH 296
+ L +L++ ++Q++ I AF L L L++++N L L +F L L +L
Sbjct: 252 TH-----LIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLT 306
Query: 297 LHHNPWNCDCDILWLAWWLREYIPTNSTCCG-RCHAPMHMRGRYLVEVDQASFQC 350
+NPW CDC I W+ WL+ YIP++ G C P +RG + E++ C
Sbjct: 307 ARNNPWFCDCSIKWVTEWLK-YIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSC 360
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 121 bits (304), Expect = 2e-27
Identities = 104/375 (27%), Positives = 171/375 (45%), Gaps = 21/375 (5%)
Query: 78 RYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTV 137
++L L N I+ + TF+ L L+ L++ RN + ++ GAF GL+++ L+L N LT
Sbjct: 218 QHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE 277
Query: 138 IPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFN 197
I G L L+EL L N I I A+ L LDL L + + +F GL
Sbjct: 278 ITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSL 336
Query: 198 LKYLNLGMCNIKDMPNLT--PLVGLEELEMSGNHFP---EIRPGSFHGLSSLKKLWVMNS 252
L L++G + + + L L+ L++ N E G+F GL L++L + +
Sbjct: 337 LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN 396
Query: 253 QVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLA 312
++ I + AF GL +L L+L+ N + SL + F+ ++ L +LHL+ + CDC + WL
Sbjct: 397 RIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLP 456
Query: 313 WWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCS---APFIMDAPRDLNISEGRM 369
W+ E S C P ++GR + V F C P I P + +G
Sbjct: 457 QWVAEN-NFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSN 515
Query: 370 AELKCRTPPMS----SVKW-----LLPNGTVLSHASRHPRISVLNDGT--LNFSHVLLSD 418
C S + W LL + + ++A + + + T L V +
Sbjct: 516 LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 575
Query: 419 TGVYTCMVTNVAGNS 433
G Y C+++N G+S
Sbjct: 576 EGKYQCVISNHFGSS 590
Score = 88.2 bits (217), Expect = 2e-17
Identities = 77/266 (28%), Positives = 124/266 (46%), Gaps = 10/266 (3%)
Query: 41 AGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHH 100
A + CP+ C C + C+R+ L+ +P+ +PS L+L N + I+A + HL
Sbjct: 42 AAERPCPTTCRCLGDL--LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQS 99
Query: 101 LEVLQLGRNSIRQI-EVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPI 159
L ++L N + I +G + A++ L L N + I + L L L +N I
Sbjct: 100 LREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNI 157
Query: 160 ESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFN-LKYLNLGMCNIKDM-PNLTPL 217
+ + AF + L L L ++ + G F+ L N L L L I + P + L
Sbjct: 158 SELQT-AFPAL-QLKYLYLNS-NRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKL 214
Query: 218 VGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNN 277
L+ LE++ N + +F GL +LK L + + V+ + AF GL+++ L L HNN
Sbjct: 215 PQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNN 274
Query: 278 LSSLPHDLFTPLRYLVELHLHHNPWN 303
L+ + L L ELHL N N
Sbjct: 275 LTEITKGWLYGLLMLQELHLSQNAIN 300
Score = 52.4 bits (124), Expect = 1e-06
Identities = 71/272 (26%), Positives = 107/272 (39%), Gaps = 47/272 (17%)
Query: 353 PFIMDAPRDLNISEGRMAELKCRTP--PMSSVKWLLPNGTVLSHASRHPRISVLNDGTLN 410
P P DL I G MA L+C P + W GT A+R R+ V+ + +
Sbjct: 603 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFP-AARERRMHVMPEDDVF 661
Query: 411 FS-HVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNY---SFFTTVTVETTEI-- 464
F V + D GVY+C N AG+ +A+A L V L T ++ TVT T +
Sbjct: 662 FIVDVKIEDIGVYSCTAQNSAGSISANATLTV----LETPSFLRPLLDRTVTKGETAVLQ 717
Query: 465 -----SPE---DTTRKYKPVPTTSTGYQPA-----------------YTTSTTVLIQTTR 499
SP + T+ P+ T + A YT + + T R
Sbjct: 718 CIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTER 777
Query: 500 VPKQVAVPATDTTDKMQ---TSLDEVMKTT--KIIIGCFVAVTLLAAAMLIVFYKLRKRH 554
+++V T T D Q SLD+ T +II V + +++ Y R+R+
Sbjct: 778 GNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRN 837
Query: 555 QQRSTVTAARTVEIIQVDEDIPAATSAAATAA 586
+ S T + DIP+ S+ T A
Sbjct: 838 EDCSITNTDET----NLPADIPSYLSSQGTLA 865
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.132 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,434,171
Number of Sequences: 37866
Number of extensions: 1088598
Number of successful extensions: 7556
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 302
Number of HSP's successfully gapped in prelim test: 244
Number of HSP's that attempted gapping in prelim test: 3376
Number of HSP's gapped (non-prelim): 2445
length of query: 653
length of database: 18,247,518
effective HSP length: 109
effective length of query: 544
effective length of database: 14,120,124
effective search space: 7681347456
effective search space used: 7681347456
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.