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Search of human proteins with 110225358
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110225358 tetratricopeptide repeat domain 7A [Homo sapiens]
(858 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110225358 tetratricopeptide repeat domain 7A [Homo sapiens] 1689 0.0
gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens] 827 0.0
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 54 6e-07
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 54 6e-07
gi|118766328 transmembrane and tetratricopeptide repeat containi... 52 2e-06
gi|118766330 transmembrane and tetratricopeptide repeat containi... 52 2e-06
gi|83415184 transmembrane and tetratricopeptide repeat containin... 50 7e-06
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 46 1e-04
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 46 1e-04
gi|22749211 transmembrane and tetratricopeptide repeat containin... 44 8e-04
gi|21735548 centrosomal protein 2 [Homo sapiens] 42 0.002
gi|7661910 tetratricopeptide repeat domain 35 [Homo sapiens] 42 0.002
gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens] 41 0.005
gi|6912398 general transcription factor IIIC, polypeptide 3, 102... 40 0.007
gi|224809432 transmembrane and tetratricopeptide repeat containi... 38 0.035
gi|118402578 anaphase-promoting complex, subunit 6 [Homo sapiens] 37 0.060
gi|118402580 anaphase-promoting complex, subunit 6 [Homo sapiens] 37 0.060
gi|157502179 tetratricopeptide repeat domain 21A isoform 1 [Homo... 37 0.060
gi|157502177 tetratricopeptide repeat domain 21A isoform 2 [Homo... 37 0.060
gi|212549736 anaphase-promoting complex subunit 7 isoform a [Hom... 37 0.078
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 37 0.10
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 37 0.10
gi|109638749 signal recognition particle 72kDa [Homo sapiens] 36 0.13
gi|189011544 ubiquitously transcribed tetratricopeptide repeat, ... 36 0.17
gi|229577238 tetratricopeptide repeat domain 18 [Homo sapiens] 35 0.23
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi... 35 0.23
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 35 0.23
gi|7706671 peroxisomal biogenesis factor 5-like [Homo sapiens] 35 0.30
gi|212549738 anaphase-promoting complex subunit 7 isoform b [Hom... 35 0.39
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 35 0.39
>gi|110225358 tetratricopeptide repeat domain 7A [Homo sapiens]
Length = 858
Score = 1689 bits (4374), Expect = 0.0
Identities = 858/858 (100%), Positives = 858/858 (100%)
Query: 1 MAAKGAHGSYLKVESELERCRAEGHWDRMPELVRQLQTLSMPGGGGNRRGSPSAAFTFPD 60
MAAKGAHGSYLKVESELERCRAEGHWDRMPELVRQLQTLSMPGGGGNRRGSPSAAFTFPD
Sbjct: 1 MAAKGAHGSYLKVESELERCRAEGHWDRMPELVRQLQTLSMPGGGGNRRGSPSAAFTFPD 60
Query: 61 TDDFGKLLLAEALLEQCLKENHAKIKDSMPLLEKNEPKMSEAKNYLSSILNHGRLSPQYM 120
TDDFGKLLLAEALLEQCLKENHAKIKDSMPLLEKNEPKMSEAKNYLSSILNHGRLSPQYM
Sbjct: 61 TDDFGKLLLAEALLEQCLKENHAKIKDSMPLLEKNEPKMSEAKNYLSSILNHGRLSPQYM 120
Query: 121 CEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLSEAFVIKGLSLERLP 180
CEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLSEAFVIKGLSLERLP
Sbjct: 121 CEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLSEAFVIKGLSLERLP 180
Query: 181 NSIASRFRLTEREEEVITCFERASWIAQVFLQELEKTTNNSTSRHLKGCHPLDYELTYFL 240
NSIASRFRLTEREEEVITCFERASWIAQVFLQELEKTTNNSTSRHLKGCHPLDYELTYFL
Sbjct: 181 NSIASRFRLTEREEEVITCFERASWIAQVFLQELEKTTNNSTSRHLKGCHPLDYELTYFL 240
Query: 241 EAALQSAYVKNLKKGNIVKGMRELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECY 300
EAALQSAYVKNLKKGNIVKGMRELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECY
Sbjct: 241 EAALQSAYVKNLKKGNIVKGMRELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECY 300
Query: 301 WSPLSHPLPEFMGKEESSFATQALRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDV 360
WSPLSHPLPEFMGKEESSFATQALRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDV
Sbjct: 301 WSPLSHPLPEFMGKEESSFATQALRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDV 360
Query: 361 VLSRVPEQEEDRTVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQV 420
VLSRVPEQEEDRTVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQV
Sbjct: 361 VLSRVPEQEEDRTVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQV 420
Query: 421 ALSMVACGKSAYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLRWLEEAEHFAMMVISLGE 480
ALSMVACGKSAYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLRWLEEAEHFAMMVISLGE
Sbjct: 421 ALSMVACGKSAYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLRWLEEAEHFAMMVISLGE 480
Query: 481 EAGEFLPKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPSDPQVILYVSL 540
EAGEFLPKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPSDPQVILYVSL
Sbjct: 481 EAGEFLPKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPSDPQVILYVSL 540
Query: 541 QLALVRQISSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENF 600
QLALVRQISSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENF
Sbjct: 541 QLALVRQISSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENF 600
Query: 601 NLMFTKVKLEQVLKGPEEALVTCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLTMKKQSGM 660
NLMFTKVKLEQVLKGPEEALVTCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLTMKKQSGM
Sbjct: 601 NLMFTKVKLEQVLKGPEEALVTCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLTMKKQSGM 660
Query: 661 HLTLPDAHDADSGSRRASSIAASRLEEAMSELTMPSSVLKQGPMQLWTTLEQIWLQAAEL 720
HLTLPDAHDADSGSRRASSIAASRLEEAMSELTMPSSVLKQGPMQLWTTLEQIWLQAAEL
Sbjct: 661 HLTLPDAHDADSGSRRASSIAASRLEEAMSELTMPSSVLKQGPMQLWTTLEQIWLQAAEL 720
Query: 721 FMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVR 780
FMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVR
Sbjct: 721 FMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVR 780
Query: 781 IMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTAL 840
IMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTAL
Sbjct: 781 IMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTAL 840
Query: 841 ELEASSPVLPFSIIPREL 858
ELEASSPVLPFSIIPREL
Sbjct: 841 ELEASSPVLPFSIIPREL 858
>gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens]
Length = 843
Score = 827 bits (2136), Expect = 0.0
Identities = 431/867 (49%), Positives = 615/867 (70%), Gaps = 33/867 (3%)
Query: 1 MAAKGAHGSYLKVESELERCRAEGHWDRMPELVRQLQTLSMPGGGGNRRGSPSAAFTFPD 60
MA K A GS ++E+E+ERCR+E W+R+PELV+QL +
Sbjct: 1 MATKKA-GS--RLETEIERCRSECQWERIPELVKQLSAKLIAN----------------- 40
Query: 61 TDDFGKLLLAEALLEQCLKENHAKIKDSMPLLEKNEPKMSEAKNYLSSILNHGRLSPQYM 120
DD +LLL E+ LEQ LKE H + + P K P+++E + +L++ L+ G L +++
Sbjct: 41 -DDMAELLLGESKLEQYLKE-HPLRQGASPRGPK--PQLTEVRKHLTAALDRGNLKSEFL 96
Query: 121 CEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLSEAFVIKGLSLERLP 180
E+ LI+ KL+YVEG Y++A+++YAR G+DD+ + P Y++R+++EA+ KGL LE+LP
Sbjct: 97 QESNLIMAKLNYVEGDYKEALNIYARVGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLP 156
Query: 181 NSIASRFRLTEREEEVITCFERASWIAQVFLQELEKTT-NNSTSRHLK-GCHPLDYELTY 238
S ++ +RE++VITC+E+A IA ++LQE+E+ +N +R K G P D EL +
Sbjct: 157 ISSSTSNLHVDREQDVITCYEKAGDIALLYLQEIERVILSNIQNRSPKPGPAPHDQELGF 216
Query: 239 FLEAALQSAYVKNLKKGNIVKGMRELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEE 298
FLE LQ A+V K GN+ +G+ RE+LR VET+ TQN ++ A+ LA +LL + E+
Sbjct: 217 FLETGLQRAHVLYFKNGNLTRGVGRFRELLRAVETRTTQNLRMTIARQLAEILLRGMCEQ 276
Query: 299 CYWSPLSHP-----LPEFMGKEESSFATQALRKPHLYEGDNLYCPKDNIEEALLLLLISE 353
YW+PL P L + + K ++ R+ +Y G+N++CP++N EEALLLLLISE
Sbjct: 277 SYWNPLEDPPCQSPLDDPLRKGANTKTYTLTRRARVYSGENIFCPQENTEEALLLLLISE 336
Query: 354 SMATRDVVLSRVPEQEEDRTVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGE 413
SMA RD VLSR+PE + DR +SLQ+A+ +YDLL+I LGRRGQY MLSECLERAMKFAF E
Sbjct: 337 SMANRDAVLSRIPEHKSDRLISLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEE 396
Query: 414 FHLWYQVALSMVACGKSAYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLRWLEEAEHFAM 473
FHLWYQ ALS++A GKSA AV +L+EC++L+P D T+PL+AAK+C+GSL WLEEAE FA
Sbjct: 397 FHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAK 456
Query: 474 MVISLGEEAGEFLPKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPSDPQ 533
V+ +GE+ EF KGYLALGLTYSLQATDA+L+ Q+ L RKAL +RA L+P+D Q
Sbjct: 457 TVVDVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQ 516
Query: 534 VILYVSLQLALVRQISSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAI 593
Y++LQLA+ RQI A+ +++AL+++ DDA++LHLLALL SAQKH+ AL++++MA+
Sbjct: 517 AAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMAL 576
Query: 594 TEHPENFNLMFTKVKLEQVLKGPEEALVTCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLT 653
+E+PENF L+F+KVKL+ + +GP+EAL+TC+ +L++W++ Y+ + + S +
Sbjct: 577 SEYPENFILLFSKVKLQSLCRGPDEALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTI 636
Query: 654 MKKQSGMHLTLPDAHDADSGSRRASSIAASRLEEAMSEL--TMPSSVLKQGPMQLWTTLE 711
++ +TLPD D ++GS A+S+AASR+E+A+SE+ ++ SS KQGP+ W TL
Sbjct: 637 ADRRQLNTITLPDFSDPETGSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLA 696
Query: 712 QIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEA 771
QIWL AAE+++ EA C QEAA LFP SH+VLYMRG++AE++G+++EA++ Y+EA
Sbjct: 697 QIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEA 756
Query: 772 LTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEA 831
L ++P V+ M L L+L +LG SLA+K+LRDAV+ ST HE W GLGEVLQAQG + A
Sbjct: 757 LAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAA 816
Query: 832 AVDCFLTALELEASSPVLPFSIIPREL 858
A +CFLTALELEASSP +PF+IIPR L
Sbjct: 817 ATECFLTALELEASSPAVPFTIIPRVL 843
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 53.9 bits (128), Expect = 6e-07
Identities = 33/125 (26%), Positives = 58/125 (46%)
Query: 718 AELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPD 777
A E+ + EA C A L PT L + +GN+EEA +LY++AL V P+
Sbjct: 290 ANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPE 349
Query: 778 GVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFL 837
+L +L + G A ++A+ T +A+ +G L+ + A+ C+
Sbjct: 350 FAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYT 409
Query: 838 TALEL 842
A+++
Sbjct: 410 RAIQI 414
Score = 52.0 bits (123), Expect = 2e-06
Identities = 42/145 (28%), Positives = 61/145 (42%), Gaps = 5/145 (3%)
Query: 699 LKQGPMQLWTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVK 758
+KQ P+ L + + ++ E+ L+EA + A L P
Sbjct: 72 IKQNPL-----LAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAA 126
Query: 759 GNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQG 818
G++E A Q Y AL NPD + LG +L LG A+ A+E Q AW
Sbjct: 127 GDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSN 186
Query: 819 LGEVLQAQGQNEAAVDCFLTALELE 843
LG V AQG+ A+ F A+ L+
Sbjct: 187 LGCVFNAQGEIWLAIHHFEKAVTLD 211
Score = 41.6 bits (96), Expect = 0.003
Identities = 30/130 (23%), Positives = 58/130 (44%)
Query: 718 AELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPD 777
A + EQ +++EA ++A +FP + + + +G L+EA YKEA+ ++P
Sbjct: 324 ANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPT 383
Query: 778 GVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFL 837
++G L + A + A++ +A L + + G A+ +
Sbjct: 384 FADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYR 443
Query: 838 TALELEASSP 847
TAL+L+ P
Sbjct: 444 TALKLKPDFP 453
Score = 41.2 bits (95), Expect = 0.004
Identities = 27/97 (27%), Positives = 47/97 (48%)
Query: 752 GRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQST 811
G + + +G L+EA + Y+ AL + PD + +L L G A + A++
Sbjct: 86 GNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPD 145
Query: 812 CHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSPV 848
+ LG +L+A G+ E A C+L A+E + + V
Sbjct: 146 LYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAV 182
Score = 41.2 bits (95), Expect = 0.004
Identities = 30/98 (30%), Positives = 44/98 (44%)
Query: 752 GRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQST 811
G L + G LEEAK Y +A+ P+ +LG + + G LA AV
Sbjct: 154 GNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPN 213
Query: 812 CHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSPVL 849
+A+ LG VL+ + AV +L AL L + V+
Sbjct: 214 FLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVV 251
Score = 39.3 bits (90), Expect = 0.016
Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 7/136 (5%)
Query: 707 WTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQ 766
W+ L ++ E+++ H ++A L P G + + + A
Sbjct: 184 WSNLGCVFNAQGEIWLAIHHF-------EKAVTLDPNFLDAYINLGNVLKEARIFDRAVA 236
Query: 767 LYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQ 826
Y AL+++P+ + +L + G LA R A+E Q +A+ L L+ +
Sbjct: 237 AYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEK 296
Query: 827 GQNEAAVDCFLTALEL 842
G A DC+ TAL L
Sbjct: 297 GSVAEAEDCYNTALRL 312
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 53.9 bits (128), Expect = 6e-07
Identities = 33/125 (26%), Positives = 58/125 (46%)
Query: 718 AELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPD 777
A E+ + EA C A L PT L + +GN+EEA +LY++AL V P+
Sbjct: 300 ANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPE 359
Query: 778 GVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFL 837
+L +L + G A ++A+ T +A+ +G L+ + A+ C+
Sbjct: 360 FAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYT 419
Query: 838 TALEL 842
A+++
Sbjct: 420 RAIQI 424
Score = 52.0 bits (123), Expect = 2e-06
Identities = 42/145 (28%), Positives = 61/145 (42%), Gaps = 5/145 (3%)
Query: 699 LKQGPMQLWTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVK 758
+KQ P+ L + + ++ E+ L+EA + A L P
Sbjct: 82 IKQNPL-----LAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAA 136
Query: 759 GNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQG 818
G++E A Q Y AL NPD + LG +L LG A+ A+E Q AW
Sbjct: 137 GDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSN 196
Query: 819 LGEVLQAQGQNEAAVDCFLTALELE 843
LG V AQG+ A+ F A+ L+
Sbjct: 197 LGCVFNAQGEIWLAIHHFEKAVTLD 221
Score = 41.6 bits (96), Expect = 0.003
Identities = 30/130 (23%), Positives = 58/130 (44%)
Query: 718 AELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPD 777
A + EQ +++EA ++A +FP + + + +G L+EA YKEA+ ++P
Sbjct: 334 ANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPT 393
Query: 778 GVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFL 837
++G L + A + A++ +A L + + G A+ +
Sbjct: 394 FADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYR 453
Query: 838 TALELEASSP 847
TAL+L+ P
Sbjct: 454 TALKLKPDFP 463
Score = 41.2 bits (95), Expect = 0.004
Identities = 27/97 (27%), Positives = 47/97 (48%)
Query: 752 GRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQST 811
G + + +G L+EA + Y+ AL + PD + +L L G A + A++
Sbjct: 96 GNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPD 155
Query: 812 CHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSPV 848
+ LG +L+A G+ E A C+L A+E + + V
Sbjct: 156 LYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAV 192
Score = 41.2 bits (95), Expect = 0.004
Identities = 30/98 (30%), Positives = 44/98 (44%)
Query: 752 GRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQST 811
G L + G LEEAK Y +A+ P+ +LG + + G LA AV
Sbjct: 164 GNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPN 223
Query: 812 CHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSPVL 849
+A+ LG VL+ + AV +L AL L + V+
Sbjct: 224 FLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVV 261
Score = 39.3 bits (90), Expect = 0.016
Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 7/136 (5%)
Query: 707 WTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQ 766
W+ L ++ E+++ H ++A L P G + + + A
Sbjct: 194 WSNLGCVFNAQGEIWLAIHHF-------EKAVTLDPNFLDAYINLGNVLKEARIFDRAVA 246
Query: 767 LYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQ 826
Y AL+++P+ + +L + G LA R A+E Q +A+ L L+ +
Sbjct: 247 AYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEK 306
Query: 827 GQNEAAVDCFLTALEL 842
G A DC+ TAL L
Sbjct: 307 GSVAEAEDCYNTALRL 322
>gi|118766328 transmembrane and tetratricopeptide repeat containing
4 isoform 2 [Homo sapiens]
Length = 741
Score = 52.0 bits (123), Expect = 2e-06
Identities = 35/113 (30%), Positives = 55/113 (48%)
Query: 735 QEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGH 794
+ A + P + V Y G+ KGN A + Y+EA+ +NP V M++LG +L
Sbjct: 472 RSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNE 531
Query: 795 KSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSP 847
A+++L AV+ Q AW LG V + + EAA + TA++ P
Sbjct: 532 LQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYP 584
Score = 38.9 bits (89), Expect = 0.021
Identities = 20/85 (23%), Positives = 45/85 (52%)
Query: 759 GNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQG 818
G +QL++ AL+V P ++ +++G L+ G+++ A + R+AV A
Sbjct: 462 GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNN 521
Query: 819 LGEVLQAQGQNEAAVDCFLTALELE 843
LG +L+ + + + A + A++++
Sbjct: 522 LGNILKERNELQEAEELLSLAVQIQ 546
Score = 38.9 bits (89), Expect = 0.021
Identities = 22/87 (25%), Positives = 40/87 (45%)
Query: 714 WLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALT 773
W L +L +A +EA L P HS+++ + +E++ L+ +A+
Sbjct: 621 WNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIK 680
Query: 774 VNPDGVRIMHSLGLMLSRLGHKSLAQK 800
NP+ +L ++ R GH LA+K
Sbjct: 681 ANPNAASYHGNLAVLYHRWGHLDLAKK 707
Score = 35.8 bits (81), Expect = 0.17
Identities = 23/109 (21%), Positives = 51/109 (46%)
Query: 735 QEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGH 794
+EA L P + G + + + L+EA++L A+ + PD +LG++ + L
Sbjct: 506 REAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKR 565
Query: 795 KSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELE 843
A++ R A++ + + + LG + ++ A++ + A L+
Sbjct: 566 FEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLK 614
>gi|118766330 transmembrane and tetratricopeptide repeat containing
4 isoform 1 [Homo sapiens]
Length = 760
Score = 52.0 bits (123), Expect = 2e-06
Identities = 35/113 (30%), Positives = 55/113 (48%)
Query: 735 QEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGH 794
+ A + P + V Y G+ KGN A + Y+EA+ +NP V M++LG +L
Sbjct: 491 RSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNE 550
Query: 795 KSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSP 847
A+++L AV+ Q AW LG V + + EAA + TA++ P
Sbjct: 551 LQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYP 603
Score = 38.9 bits (89), Expect = 0.021
Identities = 20/85 (23%), Positives = 45/85 (52%)
Query: 759 GNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQG 818
G +QL++ AL+V P ++ +++G L+ G+++ A + R+AV A
Sbjct: 481 GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNN 540
Query: 819 LGEVLQAQGQNEAAVDCFLTALELE 843
LG +L+ + + + A + A++++
Sbjct: 541 LGNILKERNELQEAEELLSLAVQIQ 565
Score = 38.9 bits (89), Expect = 0.021
Identities = 22/87 (25%), Positives = 40/87 (45%)
Query: 714 WLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALT 773
W L +L +A +EA L P HS+++ + +E++ L+ +A+
Sbjct: 640 WNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIK 699
Query: 774 VNPDGVRIMHSLGLMLSRLGHKSLAQK 800
NP+ +L ++ R GH LA+K
Sbjct: 700 ANPNAASYHGNLAVLYHRWGHLDLAKK 726
Score = 35.8 bits (81), Expect = 0.17
Identities = 23/109 (21%), Positives = 51/109 (46%)
Query: 735 QEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGH 794
+EA L P + G + + + L+EA++L A+ + PD +LG++ + L
Sbjct: 525 REAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKR 584
Query: 795 KSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELE 843
A++ R A++ + + + LG + ++ A++ + A L+
Sbjct: 585 FEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLK 633
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 50.4 bits (119), Expect = 7e-06
Identities = 74/346 (21%), Positives = 137/346 (39%), Gaps = 27/346 (7%)
Query: 509 KQDELHRKALQTLERAQQLAPSDPQVILYVSLQLALVRQISSAMEQLQEALKVRKDDAHA 568
KQ+E+ Q P + +V + L + A+ + ALK+ A A
Sbjct: 352 KQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASA 411
Query: 569 LHLLALLF----SAQKHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCR 624
L+ L L A+ ++Q AL + HP++ +F L + + EEA+ +
Sbjct: 412 LNNLGTLTRDTAEAKMYYQRALQL-------HPQHNRALFNLGNLLKSQEKKEEAITLLK 464
Query: 625 QVLRLWQTLY-SFSQLGGLEKDGSFGEGLTMKKQSGMHLTLPDAHDADSGSRRASSIAAS 683
++ ++S L L + + Q+G+ PD+ D + + +
Sbjct: 465 DSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIK-NCPDSSDLHN-NYGVFLVDTG 522
Query: 684 RLEEAMSELTMPSSVLKQGPMQ--LWTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGLF 741
E+A++ +K P L +++ E M ++ K A +A L
Sbjct: 523 LPEKAVAHY---QQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILS 579
Query: 742 PTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKV 801
P G L G EEA Q+Y+EA + P + +L +L+ +G A+K+
Sbjct: 580 PL--------GALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKM 631
Query: 802 LRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSP 847
V ++ C E ++ L + Q ++ A+D AL+L+ P
Sbjct: 632 TNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDP 677
Score = 43.1 bits (100), Expect = 0.001
Identities = 50/231 (21%), Positives = 91/231 (39%), Gaps = 21/231 (9%)
Query: 380 AAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAYAVSLLRE 439
A Y L+ L + ++ E + +K L + +V G AV+ ++
Sbjct: 474 ADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQ 533
Query: 440 CVKLRPSDPTVPLMAAKVCIGSLRWLEEAEHFAMMVISLGEEAGEFLPKGYLALGLTYSL 499
+KL PS + ++ SL AE + + + +A P G L Y+
Sbjct: 534 AIKLSPSHHVAMVNLGRL-YRSLGENSMAEEWYKRALQVAHKAEILSPLG----ALYYNT 588
Query: 500 QATDATLKSKQDELHRKALQTLERAQQLAPSDPQVILYVSLQLALVRQISSAMEQLQEAL 559
+ +ALQ + A L PS ++ L ++ LA++ Q A + +
Sbjct: 589 GR------------YEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIV 636
Query: 560 KVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPEN----FNLMFTK 606
LL+ ++S Q++H ALD ++ A+ P++ L FTK
Sbjct: 637 SEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTK 687
Score = 38.9 bits (89), Expect = 0.021
Identities = 30/157 (19%), Positives = 65/157 (41%)
Query: 693 TMPSSVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRG 752
T + + Q +QL + L Q+ +EA ++++ P
Sbjct: 422 TAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLA 481
Query: 753 RLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTC 812
L + +EA+++Y+ + PD + ++ G+ L G A + A++ +
Sbjct: 482 SLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSH 541
Query: 813 HEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSPVL 849
H A LG + ++ G+N A + + AL++ + +L
Sbjct: 542 HVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEIL 578
>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
Length = 519
Score = 46.2 bits (108), Expect = 1e-04
Identities = 28/106 (26%), Positives = 57/106 (53%), Gaps = 1/106 (0%)
Query: 745 HSVLY-MRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLR 803
H + Y M G++ ++G+L++A ++YK+A+ +P+ ++ +LGL+ +LG A + L
Sbjct: 167 HDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLG 226
Query: 804 DAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSPVL 849
+A+ T ++A G ++Q G + A+ + SP L
Sbjct: 227 NALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPL 272
Score = 36.2 bits (82), Expect = 0.13
Identities = 35/138 (25%), Positives = 64/138 (46%), Gaps = 4/138 (2%)
Query: 713 IWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEAL 772
I++QA +F + +++E+ Q A L P S L R + G + A ++Y EA
Sbjct: 70 IYVQAL-IFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAA 128
Query: 773 TVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHE-AWQGLGEVLQAQGQNEA 831
+N I H+LG+ L + AQ L +A+ H+ + LG++ +G +
Sbjct: 129 KLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNR--HDLTYIMLGKIHLLEGDLDK 186
Query: 832 AVDCFLTALELEASSPVL 849
A++ + A+E + L
Sbjct: 187 AIEVYKKAVEFSPENTEL 204
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 46.2 bits (108), Expect = 1e-04
Identities = 75/405 (18%), Positives = 149/405 (36%), Gaps = 27/405 (6%)
Query: 433 AVSLLRECVKLRPSDPTVPLMAAKVCIGSLRWLEEAEHFAMMVISLGEEAGEFLPKGYLA 492
A++ ++ ++ P P + C L LE+A + L +
Sbjct: 182 ALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKARLAFSRALELNSKC---------- 231
Query: 493 LGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPSDPQVILYVSLQLALVRQISSAM 552
+G L + L +K+ + + +Q L RA + PS+P V+ +++ + S
Sbjct: 232 VGALVGLAVLE--LNNKEADSIKNGVQLLSRAYTIDPSNPMVLNHLANHFFFKKDYSKVQ 289
Query: 553 EQLQEAL---KVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKL 609
A +V A + + LA F Q+ + A A +F L F +
Sbjct: 290 HLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQ 349
Query: 610 EQVLKGPEEALVTC-RQVLRLWQTLY-SFSQLGGLEKDGSFGEGLTMKKQSGMHLTLPDA 667
+ +G +E C +VL+ + Y + LG L E + K +T
Sbjct: 350 MYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTEQYP 409
Query: 668 HDADSGSRRASSIAASRLEEAMSELTMPSSVLKQG-----PMQLWTTLEQIWLQAAELFM 722
D ++ A + + ++ A+S + +L++ P ++ + + + L
Sbjct: 410 DDVEAWIELAQILEQTDIQGALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLGE 469
Query: 723 EQQHL-----KEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPD 777
+++ + + S + Y RL E EA++LYK L +P+
Sbjct: 470 AKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPN 529
Query: 778 GVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEV 822
V LG M G+ A ++A++ +AW +G +
Sbjct: 530 YVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNL 574
>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
[Homo sapiens]
Length = 836
Score = 43.5 bits (101), Expect = 8e-04
Identities = 35/130 (26%), Positives = 57/130 (43%), Gaps = 3/130 (2%)
Query: 719 ELFMEQQHLKEAGFCIQEAAGLFPTS---HSVLYMRGRLAEVKGNLEEAKQLYKEALTVN 775
+L+ EQ H +EA +EA P S+ M G L EA+ Y E+L
Sbjct: 614 KLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSK 673
Query: 776 PDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDC 835
D + + G +L+ G KS A+K+ A+E T + G+ L + + A +
Sbjct: 674 TDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEM 733
Query: 836 FLTALELEAS 845
A EL+++
Sbjct: 734 AKKAAELDST 743
Score = 37.0 bits (84), Expect = 0.078
Identities = 37/149 (24%), Positives = 63/149 (42%), Gaps = 14/149 (9%)
Query: 709 TLEQIWLQAAELFMEQQHLKEAGFCIQEAAGL------FPTSH-----SVLYMRGRLAEV 757
TL +L + M Q +EA + + + P +H S LY G+L
Sbjct: 559 TLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHE 618
Query: 758 KGNLEEAKQLYKEALTVNPDGV---RIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHE 814
+G+ EEA +YKEA+ P + + +G RL A+ +++ ++
Sbjct: 619 QGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIP 678
Query: 815 AWQGLGEVLQAQGQNEAAVDCFLTALELE 843
A G++L G+ A FL A+EL+
Sbjct: 679 AHLTYGKLLALTGRKSEAEKLFLKAIELD 707
Score = 34.3 bits (77), Expect = 0.51
Identities = 36/171 (21%), Positives = 61/171 (35%), Gaps = 18/171 (10%)
Query: 682 ASRLEEAMSELTMPSSVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGLF 741
A R + +E + S +K P + W L + Q + EA + A
Sbjct: 471 AIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNV-------LKSQSKISEAESAYRNALYYR 523
Query: 742 PTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKV 801
+LY G L + EA YK A+ P + G++L G A++
Sbjct: 524 SNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRT 583
Query: 802 -----------LRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALE 841
L+D +S+ LG++ QG E A+ + A++
Sbjct: 584 FLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQ 634
Score = 31.6 bits (70), Expect = 3.3
Identities = 18/56 (32%), Positives = 31/56 (55%), Gaps = 5/56 (8%)
Query: 127 LGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLSEAFVIKGLSLERLPNS 182
LGKL++ +G Y +A+S+Y A I M + P ++ EA+ + L +LP +
Sbjct: 612 LGKLYHEQGHYEEALSVYKEA-IQKMPRQFAPQSLYNMMGEAY----MRLSKLPEA 662
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 42.4 bits (98), Expect = 0.002
Identities = 79/341 (23%), Positives = 141/341 (41%), Gaps = 41/341 (12%)
Query: 494 GLTYSLQATDATLKSKQDEL-------HRKALQTLERAQQLAPSDPQVILYVSLQLALVR 546
GL S++ TL K+ E+ R L+ L + + +P + Q + SL+ L R
Sbjct: 2091 GLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQR 2150
Query: 547 QISSAMEQLQEALKVRKDDAHALHL------LALLFSAQKHHQHALDVVNMAITEHPENF 600
++ E+LQ AL R+ +A + LAL + K +L V M
Sbjct: 2151 EL----ERLQAAL--RQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMF-------- 2196
Query: 601 NLMFTKVKLEQVLKGPEEALVTCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLTMKKQSGM 660
L + ++ + + ++ L R+ L + L+S E +G+ + + SG+
Sbjct: 2197 -LQASVLERDSEQQRLQDELELTRRALEK-ERLHSPGATSTAELGSRGEQGVQLGEVSGV 2254
Query: 661 HLT-LPDAHDADSGSRRASSIAASRLEEAMSELTMPSSVLKQGPMQLWTTLEQIWLQAAE 719
PD + S +R L++A++ L + S L++ +QL +TLEQ+ + +
Sbjct: 2255 EAEPSPDGMEKQSWRQRLE-----HLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRK 2309
Query: 720 LFMEQQHLKEAGFC-IQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTV---- 774
L E +AG I +A PT + A+ L++ L + LT+
Sbjct: 2310 LKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQ 2369
Query: 775 NPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEA 815
D + L+ L H SL+ +L A ++T EA
Sbjct: 2370 KQDYITRSAQTSRELAGL-HHSLSHSLLAVAQAPEATVLEA 2409
>gi|7661910 tetratricopeptide repeat domain 35 [Homo sapiens]
Length = 297
Score = 42.0 bits (97), Expect = 0.002
Identities = 31/117 (26%), Positives = 47/117 (40%), Gaps = 4/117 (3%)
Query: 706 LWTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAK 765
+W EQ+ + A + + L FC+QE FP SH V + G E ++A
Sbjct: 52 IWIIYEQVMIAALDYGRDDLAL----FCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAI 107
Query: 766 QLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEV 822
QLY L +P + G A + L + +E+ EAW L E+
Sbjct: 108 QLYDRILQEDPTNTAARKRKIAIRKAQGKNVEAIRELNEYLEQFVGDQEAWHELAEL 164
Score = 41.6 bits (96), Expect = 0.003
Identities = 36/146 (24%), Positives = 69/146 (47%), Gaps = 14/146 (9%)
Query: 711 EQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVK------GNLEEA 764
++ W + AEL++ + +A FC++E + H+ LY + + AEVK NLE +
Sbjct: 155 QEAWHELAELYINEHDYAKAAFCLEEL--MMTNPHNHLYCQ-QYAEVKYTQGGLENLELS 211
Query: 765 KQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQ-KVLRDAVE----RQSTCHEAWQGL 819
++ + +AL +N +R + L + S + A K +D ++ S + A+Q
Sbjct: 212 RKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKTKKDNMKYASWAASQINRAYQFA 271
Query: 820 GEVLQAQGQNEAAVDCFLTALELEAS 845
G + + AV+ L L++ S
Sbjct: 272 GRSKKETKYSLKAVEDMLETLQITQS 297
>gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]
Length = 1564
Score = 40.8 bits (94), Expect = 0.005
Identities = 33/94 (35%), Positives = 47/94 (50%), Gaps = 14/94 (14%)
Query: 759 GNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSL--AQKVLRDAVERQ------- 809
G + EA+ L + L NPD ++ L+L ++ K L +QK L DAV +
Sbjct: 1340 GRISEAETLCTKNLKSNPDQPAVI----LLLRQVQCKPLLESQKPLPDAVLEELQKTVMS 1395
Query: 810 -STCHEAWQGLGEVLQAQGQNEAAVDCFLTALEL 842
ST AWQ L V Q+QG AA C+ +L+L
Sbjct: 1396 NSTSVPAWQWLAHVYQSQGMMRAAEMCYRKSLQL 1429
Score = 36.6 bits (83), Expect = 0.10
Identities = 71/326 (21%), Positives = 130/326 (39%), Gaps = 38/326 (11%)
Query: 547 QISSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENFNLMFTK 606
Q S A+ LQ AL+ D + L + ++ + AL A +PE+ +F
Sbjct: 579 QHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELNPESIYSVFKV 638
Query: 607 VKLEQVLKGPEEALVTCRQVLRLWQTLYSFSQLGGLEK-----------DGSFGEGLTMK 655
++Q+L +EA+ + +++ + L GL + D G+ +
Sbjct: 639 AAIQQILGKYKEAVAQYQMIIKKKEDYVP--ALKGLGECHLMMAKAALVDYLDGKAVDYI 696
Query: 656 KQSGMHLTLPDAHDADSGSRRASSIAASRLEEAMSELTMPSSVLKQGPMQLWTTLEQIWL 715
+++ + T H AD + A A++ PS V L L Q
Sbjct: 697 EKALEYFTCALQHRADVSCLWKLAGDACTCLYAVA----PSKV---NVHVLGVLLGQ--K 747
Query: 716 QAAELFMEQQHLKEAGFCIQEAAGLFPTSHS-----VLYMRG--RLAEVKGNLEEAKQLY 768
+ ++ + + L G C A L TS++ + Y R LAE N+ + K+L
Sbjct: 748 EGKQVLKKNELLHLGGRCYGRALKLMSTSNTWCDLGINYYRQAQHLAETGSNMNDLKELL 807
Query: 769 KEALTVNPDGVRI-------MHSLGLML--SRLGHKSLAQKVLRDAVERQSTCHEAWQGL 819
+++L VR+ ++LG++ S +G+ +LAQ +++ + AW L
Sbjct: 808 EKSLHCLKKAVRLDSNNHLYWNALGVVACYSGIGNYALAQHCFIKSIQSEQINAVAWTNL 867
Query: 820 GEVLQAQGQNEAAVDCFLTALELEAS 845
G + E A + F A L+ S
Sbjct: 868 GVLYLTNENIEQAHEAFKMAQSLDPS 893
>gi|6912398 general transcription factor IIIC, polypeptide 3, 102kDa
[Homo sapiens]
Length = 886
Score = 40.4 bits (93), Expect = 0.007
Identities = 24/71 (33%), Positives = 38/71 (53%), Gaps = 2/71 (2%)
Query: 714 WLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALT 773
W++ AE+ +EQ ++K+A FC +A PT+ L+ R L E G+ + A Y+ L
Sbjct: 220 WVRLAEMSLEQDNIKQAIFCYTKALKYEPTNVRYLWERSSLYEQMGDHKMAMDGYRRILN 279
Query: 774 V--NPDGVRIM 782
+ DG R M
Sbjct: 280 LLSPSDGERFM 290
Score = 39.7 bits (91), Expect = 0.012
Identities = 33/141 (23%), Positives = 57/141 (40%), Gaps = 11/141 (7%)
Query: 712 QIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEA 771
Q+W ++ M Q ++ FC++ P +H++ + G A V G+ + A Y +A
Sbjct: 701 QLWNIFNQVTMHSQDVRHHRFCLRLMLKN-PENHALCVLNGHNAFVSGSFKHALGQYVQA 759
Query: 772 LTVNPD--------GVRIMHSLGLMLSRLGHKSLAQ--KVLRDAVERQSTCHEAWQGLGE 821
+PD G+ +H H + Q L + + C E++ LG
Sbjct: 760 FRTHPDEPLYSFCIGLTFIHMASQKYVLRRHALIVQGFSFLNRYLSLRGPCQESFYNLGR 819
Query: 822 VLQAQGQNEAAVDCFLTALEL 842
L G A+ + ALEL
Sbjct: 820 GLHQLGLIHLAIHYYQKALEL 840
>gi|224809432 transmembrane and tetratricopeptide repeat containing
3 [Homo sapiens]
Length = 914
Score = 38.1 bits (87), Expect = 0.035
Identities = 28/96 (29%), Positives = 48/96 (50%), Gaps = 2/96 (2%)
Query: 758 KGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQ 817
+ LEEA QLY++A+++ PD + S G +L ++ A++ A+E + W
Sbjct: 542 ESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWY 601
Query: 818 GLGEV-LQAQGQNEAAVDCFLTALELEASSPVLPFS 852
L V ++ + NEA + F ALEL + F+
Sbjct: 602 NLAIVHIELKEPNEALKN-FNRALELNPKHKLALFN 636
>gi|118402578 anaphase-promoting complex, subunit 6 [Homo sapiens]
Length = 620
Score = 37.4 bits (85), Expect = 0.060
Identities = 26/105 (24%), Positives = 48/105 (45%), Gaps = 4/105 (3%)
Query: 708 TTLEQI----WLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEE 763
TTLE+ W+ F + +A AA L H + G + N +
Sbjct: 327 TTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKL 386
Query: 764 AKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVER 808
A++ + +AL++ P+ +MH +G++ + G A+K DA+E+
Sbjct: 387 AERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEK 431
Score = 36.2 bits (82), Expect = 0.13
Identities = 32/103 (31%), Positives = 47/103 (45%), Gaps = 4/103 (3%)
Query: 514 HRKALQTLERAQQLAPSDPQVILYVSLQLALVRQISSAMEQLQEALKVRKDDAHALHLLA 573
++ AL ++ L+ +PQ I +++ L L Q A L+ K+ K +L A
Sbjct: 19 YQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHALRSR-KLDKLYEACRYLAA 77
Query: 574 LLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLKGP 616
A K HQ ALDV++M E P N L +K E K P
Sbjct: 78 RCHYAAKEHQQALDVLDM---EEPINKRLFEKYLKDESGFKDP 117
>gi|118402580 anaphase-promoting complex, subunit 6 [Homo sapiens]
Length = 620
Score = 37.4 bits (85), Expect = 0.060
Identities = 26/105 (24%), Positives = 48/105 (45%), Gaps = 4/105 (3%)
Query: 708 TTLEQI----WLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEE 763
TTLE+ W+ F + +A AA L H + G + N +
Sbjct: 327 TTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKL 386
Query: 764 AKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVER 808
A++ + +AL++ P+ +MH +G++ + G A+K DA+E+
Sbjct: 387 AERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEK 431
Score = 36.2 bits (82), Expect = 0.13
Identities = 32/103 (31%), Positives = 47/103 (45%), Gaps = 4/103 (3%)
Query: 514 HRKALQTLERAQQLAPSDPQVILYVSLQLALVRQISSAMEQLQEALKVRKDDAHALHLLA 573
++ AL ++ L+ +PQ I +++ L L Q A L+ K+ K +L A
Sbjct: 19 YQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHALRSR-KLDKLYEACRYLAA 77
Query: 574 LLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLKGP 616
A K HQ ALDV++M E P N L +K E K P
Sbjct: 78 RCHYAAKEHQQALDVLDM---EEPINKRLFEKYLKDESGFKDP 117
>gi|157502179 tetratricopeptide repeat domain 21A isoform 1 [Homo
sapiens]
Length = 1321
Score = 37.4 bits (85), Expect = 0.060
Identities = 68/302 (22%), Positives = 116/302 (38%), Gaps = 33/302 (10%)
Query: 498 SLQATDATLKSKQDELHRKALQTLERAQQLAPSDPQVILYVSLQLALVRQISSAMEQLQE 557
SL DA + + E KAL+ + A + P D + + Q + A+E +
Sbjct: 732 SLLLGDALMSILEPE---KALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEA 788
Query: 558 ALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHP--ENFNLMFTKVKLEQVLKG 615
A K+ D L LL +K ++ A V+ A+ EH ++ M VK
Sbjct: 789 AQKINGQDFLCCDLGKLLLKLKKVNK-AEKVLKQAL-EHDIVQDIPSMMNDVKC------ 840
Query: 616 PEEALVTCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLTMKKQSGMHLTLPDAHDADSGSR 675
+L L + S + +E + + L ++ + + L S +
Sbjct: 841 ----------LLLLAKVYKSHKKEAVIE---TLNKALDLQSRILKRVPLEQPEMIPSQKQ 887
Query: 676 RASSIAASRLEEAMSELTMPSSVLK-QGPMQLWTTLEQIWLQAAELFMEQQHLKEAGFCI 734
A+SI E ++E +V + T ++ L+ A+L++ Q HL C
Sbjct: 888 LAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLD---LCE 944
Query: 735 QEAAGLFPTSHSVLYMRGRLAEV---KGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSR 791
Q A L T + +A++ K E A LY + L PD ++H L +L R
Sbjct: 945 QHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRR 1004
Query: 792 LG 793
G
Sbjct: 1005 SG 1006
>gi|157502177 tetratricopeptide repeat domain 21A isoform 2 [Homo
sapiens]
Length = 1320
Score = 37.4 bits (85), Expect = 0.060
Identities = 68/302 (22%), Positives = 116/302 (38%), Gaps = 33/302 (10%)
Query: 498 SLQATDATLKSKQDELHRKALQTLERAQQLAPSDPQVILYVSLQLALVRQISSAMEQLQE 557
SL DA + + E KAL+ + A + P D + + Q + A+E +
Sbjct: 731 SLLLGDALMSILEPE---KALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEA 787
Query: 558 ALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHP--ENFNLMFTKVKLEQVLKG 615
A K+ D L LL +K ++ A V+ A+ EH ++ M VK
Sbjct: 788 AQKINGQDFLCCDLGKLLLKLKKVNK-AEKVLKQAL-EHDIVQDIPSMMNDVKC------ 839
Query: 616 PEEALVTCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLTMKKQSGMHLTLPDAHDADSGSR 675
+L L + S + +E + + L ++ + + L S +
Sbjct: 840 ----------LLLLAKVYKSHKKEAVIE---TLNKALDLQSRILKRVPLEQPEMIPSQKQ 886
Query: 676 RASSIAASRLEEAMSELTMPSSVLK-QGPMQLWTTLEQIWLQAAELFMEQQHLKEAGFCI 734
A+SI E ++E +V + T ++ L+ A+L++ Q HL C
Sbjct: 887 LAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLD---LCE 943
Query: 735 QEAAGLFPTSHSVLYMRGRLAEV---KGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSR 791
Q A L T + +A++ K E A LY + L PD ++H L +L R
Sbjct: 944 QHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRR 1003
Query: 792 LG 793
G
Sbjct: 1004 SG 1005
>gi|212549736 anaphase-promoting complex subunit 7 isoform a [Homo
sapiens]
Length = 599
Score = 37.0 bits (84), Expect = 0.078
Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 1/82 (1%)
Query: 762 EEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGE 821
E+AK L +ALT PD ++ + +LSR +LR+A+ QS C + LG+
Sbjct: 459 EKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDC-VLHRILGD 517
Query: 822 VLQAQGQNEAAVDCFLTALELE 843
L A + + A+D + AL L+
Sbjct: 518 FLVAVNEYQEAMDQYSIALSLD 539
>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
sapiens]
Length = 830
Score = 36.6 bits (83), Expect = 0.10
Identities = 33/155 (21%), Positives = 62/155 (40%)
Query: 697 SVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAE 756
SVL + + + W A F Q+ A Q A + P + G
Sbjct: 559 SVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFV 618
Query: 757 VKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAW 816
+ L++A ++ A+ VNP + LG++ + SLA+ + A++
Sbjct: 619 LTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLL 678
Query: 817 QGLGEVLQAQGQNEAAVDCFLTALELEASSPVLPF 851
+G V A ++E A+D A+ ++ +P+ F
Sbjct: 679 CHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKF 713
>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
sapiens]
Length = 824
Score = 36.6 bits (83), Expect = 0.10
Identities = 33/155 (21%), Positives = 62/155 (40%)
Query: 697 SVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAE 756
SVL + + + W A F Q+ A Q A + P + G
Sbjct: 553 SVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFV 612
Query: 757 VKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAW 816
+ L++A ++ A+ VNP + LG++ + SLA+ + A++
Sbjct: 613 LTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLL 672
Query: 817 QGLGEVLQAQGQNEAAVDCFLTALELEASSPVLPF 851
+G V A ++E A+D A+ ++ +P+ F
Sbjct: 673 CHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKF 707
>gi|109638749 signal recognition particle 72kDa [Homo sapiens]
Length = 671
Score = 36.2 bits (82), Expect = 0.13
Identities = 58/251 (23%), Positives = 103/251 (41%), Gaps = 36/251 (14%)
Query: 551 AMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKLE 610
A++ + + L++ KDD ALH + + AL+V+N T+ N +L F K E
Sbjct: 30 ALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTH-TKVLANNSLSFEKAYCE 88
Query: 611 QVLKGPEEALVTCRQVLRLWQTLYSF--SQLGGLEKDGSFGEGLTMKKQSGMHLTLPDAH 668
L E AL T + L L LE+ + E L + + L
Sbjct: 89 YRLNRIENALKTIESANQQTDKLKELYGQVLYRLER---YDECLAVYRD------LVRNS 139
Query: 669 DADSGSRRASSIAASRLEEAMSELTMPSSV-LKQGPMQLWTTLEQIWLQAAELFMEQQHL 727
D R ++++A ++ E +P ++ L++G +L A + Q L
Sbjct: 140 QDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELC-------YNTACALIGQGQL 192
Query: 728 KEAGFCIQEAAGLFPTSHS-------------VLYMRGRLA---EVKGNLEEAKQLYKEA 771
+A +Q+A L S S + + G++A +++G EEA QLY +
Sbjct: 193 NQAMKILQKAEDLCRRSLSEDTDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQI 252
Query: 772 LTVNPDGVRIM 782
+ + P V ++
Sbjct: 253 IKLKPTDVGLL 263
>gi|189011544 ubiquitously transcribed tetratricopeptide repeat, X
chromosome [Homo sapiens]
Length = 1401
Score = 35.8 bits (81), Expect = 0.17
Identities = 30/142 (21%), Positives = 61/142 (42%), Gaps = 3/142 (2%)
Query: 708 TTLEQI-WLQAAELFMEQQHLKEAGFC--IQEAAGLFPTSHSVLYMRGRLAEVKGNLEEA 764
T L+Q+ W+ + + KE+ +Q++ P S Y GR G +++A
Sbjct: 244 TVLQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA 303
Query: 765 KQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQ 824
Y++++ + S+G++ + A + AV+ AW LG + +
Sbjct: 304 FISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYE 363
Query: 825 AQGQNEAAVDCFLTALELEASS 846
+ Q + A+ C+L A ++ S
Sbjct: 364 SCNQPQDAIKCYLNATRSKSCS 385
>gi|229577238 tetratricopeptide repeat domain 18 [Homo sapiens]
Length = 1121
Score = 35.4 bits (80), Expect = 0.23
Identities = 30/109 (27%), Positives = 48/109 (44%), Gaps = 9/109 (8%)
Query: 720 LFMEQQHLKEAGFC-----IQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTV 774
L + Q H+ + F +Q+AA + + +V ++G L + GN EAK Y+ ++
Sbjct: 933 LVLAQTHILKKNFAKAEEYLQQAAQMDYLNPNVWGLKGHLYFLSGNHSEAKACYERTISF 992
Query: 775 NPDGVR---IMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLG 820
D I LGL+ A+K A +R +C W GLG
Sbjct: 993 VVDASEMHFIFLRLGLIYLEEKEYEKAKKTYMQACKRSPSC-LTWLGLG 1040
>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
protein) [Homo sapiens]
Length = 543
Score = 35.4 bits (80), Expect = 0.23
Identities = 21/88 (23%), Positives = 42/88 (47%)
Query: 758 KGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQ 817
KG+ +A + Y EA+ NP ++ + ++L LA K + ++ + T + +
Sbjct: 373 KGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYT 432
Query: 818 GLGEVLQAQGQNEAAVDCFLTALELEAS 845
L+A A+D + AL+L++S
Sbjct: 433 RKAAALEAMKDYTKAMDVYQKALDLDSS 460
>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
sapiens]
Length = 1614
Score = 35.4 bits (80), Expect = 0.23
Identities = 60/287 (20%), Positives = 112/287 (39%), Gaps = 22/287 (7%)
Query: 573 ALLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQVLRLWQT 632
AL++S ++H A++V++ I+ + + K++ K +EA+ ++ L
Sbjct: 1125 ALIYSFCENHDKAIEVLD-GISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISH 1183
Query: 633 LYSFSQLGGLEKDGSFGEGLTMKKQSGMHLT-------LPDAHDADSGSRRA---SSIAA 682
+ D + GL ++ + +T L A D S A ++
Sbjct: 1184 SDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCY 1243
Query: 683 SRLEEAMSELTMPSSVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEAGFCIQE---AAG 739
+++ E LT VL + T +L +++E L + GF +++ AA
Sbjct: 1244 TKIRELQMALTDYGIVLLLDATE--TVKLNTFLNRGLIYVE---LGQYGFALEDFKQAAL 1298
Query: 740 LFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSL-- 797
+ T+ S+ + EEA + AL +NP + G GH
Sbjct: 1299 ISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATK 1358
Query: 798 -AQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELE 843
AQK A+ +A G LQAQG+ + A + F A++ +
Sbjct: 1359 QAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTD 1405
>gi|7706671 peroxisomal biogenesis factor 5-like [Homo sapiens]
Length = 626
Score = 35.0 bits (79), Expect = 0.30
Identities = 28/95 (29%), Positives = 38/95 (40%)
Query: 752 GRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQST 811
G L + G A + ALTV P+ + + LG L+ A + A+E Q
Sbjct: 481 GVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPG 540
Query: 812 CHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASS 846
+ LG G AV FLTAL L+ S
Sbjct: 541 FIRSRYNLGISCINLGAYREAVSNFLTALSLQRKS 575
>gi|212549738 anaphase-promoting complex subunit 7 isoform b [Homo
sapiens]
Length = 537
Score = 34.7 bits (78), Expect = 0.39
Identities = 26/79 (32%), Positives = 41/79 (51%), Gaps = 1/79 (1%)
Query: 762 EEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGE 821
E+AK L +ALT PD ++ + +LSR +LR+A+ QS C + LG+
Sbjct: 459 EKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDC-VLHRILGD 517
Query: 822 VLQAQGQNEAAVDCFLTAL 840
L A + + A+D + AL
Sbjct: 518 FLVAVNEYQEAMDQYSIAL 536
>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 34.7 bits (78), Expect = 0.39
Identities = 60/287 (20%), Positives = 112/287 (39%), Gaps = 22/287 (7%)
Query: 573 ALLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQVLRLWQT 632
AL++S ++H A++V++ I+ + + K++ K +EA+ ++ L
Sbjct: 1125 ALIYSFCENHDKAIEVLD-GISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISH 1183
Query: 633 LYSFSQLGGLEKDGSFGEGLTMKKQSGMHLT-------LPDAHDADSGSRRA---SSIAA 682
+ D + GL ++ + +T L A D S A ++
Sbjct: 1184 SDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCY 1243
Query: 683 SRLEEAMSELTMPSSVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEAGFCIQE---AAG 739
+++ E LT VL + T +L +++E L + GF +++ AA
Sbjct: 1244 TKIRELQMALTDYGIVLLLDATE--TVKLNTFLNRGLIYVE---LGQYGFALEDFKQAAL 1298
Query: 740 LFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSL-- 797
+ T+ S+ + EEA + AL +NP + G GH
Sbjct: 1299 ISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATK 1358
Query: 798 -AQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELE 843
AQK A+ +A G LQAQG+ + A + F A++ +
Sbjct: 1359 QAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTD 1405
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,166,058
Number of Sequences: 37866
Number of extensions: 1268703
Number of successful extensions: 4235
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 3953
Number of HSP's gapped (non-prelim): 307
length of query: 858
length of database: 18,247,518
effective HSP length: 111
effective length of query: 747
effective length of database: 14,044,392
effective search space: 10491160824
effective search space used: 10491160824
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.