BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] (882 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 1766 0.0 gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 724 0.0 gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 361 1e-99 gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 139 9e-33 gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 134 3e-31 gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 128 3e-29 gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 92 2e-18 gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 91 5e-18 gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 91 5e-18 gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 91 5e-18 gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 91 5e-18 gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 91 5e-18 gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 91 5e-18 gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 91 5e-18 gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 91 5e-18 gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 88 3e-17 gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 88 3e-17 gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 88 3e-17 gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 88 4e-17 gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 84 8e-16 gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 84 8e-16 gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 84 8e-16 gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 84 8e-16 gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens] 76 1e-13 gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 72 2e-12 gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 72 2e-12 gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens] 69 3e-11 gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens] 67 6e-11 gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 67 7e-11 gi|119943102 CREB binding protein isoform b [Homo sapiens] 64 6e-10 >gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] Length = 882 Score = 1766 bits (4575), Expect = 0.0 Identities = 882/882 (100%), Positives = 882/882 (100%) Query: 1 MLLGASWLCASKAAAAAAQSEGDEDRPGERRRRRAAATAAGAGEDMDESSLLDLLECSVC 60 MLLGASWLCASKAAAAAAQSEGDEDRPGERRRRRAAATAAGAGEDMDESSLLDLLECSVC Sbjct: 1 MLLGASWLCASKAAAAAAQSEGDEDRPGERRRRRAAATAAGAGEDMDESSLLDLLECSVC 60 Query: 61 LERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDG 120 LERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDG Sbjct: 61 LERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDG 120 Query: 121 IRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRE 180 IRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRE Sbjct: 121 IRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRE 180 Query: 181 LATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ 240 LATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ Sbjct: 181 LATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ 240 Query: 241 GFLPASYIQCIQPLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEG 300 GFLPASYIQCIQPLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEG Sbjct: 241 GFLPASYIQCIQPLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEG 300 Query: 301 MLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSS 360 MLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSS Sbjct: 301 MLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSS 360 Query: 361 GAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARI 420 GAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARI Sbjct: 361 GAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARI 420 Query: 421 GDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKS 480 GDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKS Sbjct: 421 GDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKS 480 Query: 481 DELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVG 540 DELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVG Sbjct: 481 DELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVG 540 Query: 541 GSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTA 600 GSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTA Sbjct: 541 GSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTA 600 Query: 601 SQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQM 660 SQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQM Sbjct: 601 SQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQM 660 Query: 661 CPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKK 720 CPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKK Sbjct: 661 CPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKK 720 Query: 721 SGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRAGSCPIES 780 SGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRAGSCPIES Sbjct: 721 SGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRAGSCPIES 780 Query: 781 EMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEA 840 EMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEA Sbjct: 781 EMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEA 840 Query: 841 EIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF 882 EIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF Sbjct: 841 EIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF 882 >gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] Length = 888 Score = 724 bits (1868), Expect = 0.0 Identities = 442/930 (47%), Positives = 543/930 (58%), Gaps = 137/930 (14%) Query: 46 MDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGV 105 MDES+LLDLLEC VCLERLD +AKVLPCQHTFC+RCL IV SR+ELRCPECR LVG GV Sbjct: 1 MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGV 60 Query: 106 DELPANILLVRLLDGIRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPV 165 +ELP+NILLVRLLDGI+QRP GGS G + L A + Sbjct: 61 EELPSNILLVRLLDGIKQRPWKPGPGGGS-------GTNCTNALRSQSSTVANCS----- 108 Query: 166 FLSAAAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRR 225 S S+ G + S + P P LP KALY+YEGKEPGDLKF+KGDII+LRR Sbjct: 109 --SKDLQSSQGGQQPRVQSWSPPVRGIP-QLPCAKALYNYEGKEPGDLKFSKGDIIILRR 165 Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDE 285 +VDE WYHGE++G GF P +++Q I+PLP PPQ KALYDFE+KDK+ DKDCL F KD+ Sbjct: 166 QVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDD 225 Query: 286 ILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDS 345 +LTV+RRVDENWAEGML DKIGIFP+ YVE N +AKQLIE DKP +A S + Sbjct: 226 VLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKP---PVPGVDAGECSSA 282 Query: 346 GAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISA 405 A +S AP + D KKNTKKRHSFT+L++ ++SSQA+ +RHSMEIS Sbjct: 283 AAQSSTAP--------------KHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISP 328 Query: 406 PVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGT------- 458 PVLISSS+P AAARI +L+ LSC+AP+Q S+ G T P + +G T Sbjct: 329 PVLISSSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPSDVPY 388 Query: 459 --------PPKVQLPL-------------------------------------------N 467 PP PL + Sbjct: 389 QAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPS 448 Query: 468 VYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSR-- 525 VY+A+Y Y P+K DELEL KGEM+ V E+CQDGWFKG S+ T GVFPGNYV PV+R Sbjct: 449 VYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAV 508 Query: 526 -------VPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAH 578 VP AG V SP G G+G S + PA ++ Sbjct: 509 TNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNGVAGSPSVV--PAAVVS----- 561 Query: 579 AQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLP 638 A H SP L + Q T +QAR+ + T A A Q+RPTA V+P++ QN+ P Sbjct: 562 AAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVA---AHNQERPTAAVTPIQVQNAAGLSP 618 Query: 639 AT-SLRPHSVVSPQHSHQPPVQMCPRPAI-------PLTSAASA-ITPPNVSAANLNGEA 689 A+ L HS+ SPQ + P AI PL AA+A +T P++++A+L E Sbjct: 619 ASVGLSHHSLASPQPAPLMPGSATHTAAISISRASAPLACAAAAPLTSPSITSASLEAEP 678 Query: 690 GGGPIGVL--------STSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSRSPPS 741 G + VL S SS K KKEKK GLLKLL+GASTK+K R P Sbjct: 679 SGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKKEKK-GLLKLLSGASTKRKPRVSPP 737 Query: 742 VSPTHDPQVAVDAL-LQGAVGPEVSSLSIHGRAGSCPIESE-------MQGAMGMEPLHR 793 SPT + ++ L LQGAVGPE+ HGRAGSCP++ + A+ + HR Sbjct: 738 ASPTLEVELGSAELPLQGAVGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHR 797 Query: 794 KAGSLD--LNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVF 851 KA SLD + P RQA S+ + E + + ER+RVVVSYPPQSEAE+ELKEGDIVF Sbjct: 798 KASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVF 857 Query: 852 VHKKREDGWYKGTLQRNGRTGLFPGSFVES 881 VHKKREDGW+KGTLQRNG+TGLFPGSFVE+ Sbjct: 858 VHKKREDGWFKGTLQRNGKTGLFPGSFVEN 887 >gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] Length = 729 Score = 361 bits (927), Expect = 1e-99 Identities = 258/755 (34%), Positives = 371/755 (49%), Gaps = 94/755 (12%) Query: 46 MDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGV 105 MD+ +LLDLLEC VC E+LD TAKVLPCQHTFC+ CL+ + + ELRCPECR V + Sbjct: 1 MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRVFKAHKELRCPECRTPVFSNI 60 Query: 106 DELPANILLVRLLDGIRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPV 165 + LPAN+LLVRLLDG+R GQS+ G G + PG+ Sbjct: 61 EALPANLLLVRLLDGVRS------------------GQSS-------GRGGSFRRPGTMT 95 Query: 166 FLSAAAGSTAGSLRELATSRTAPAAK-NPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLR 224 T + + R P + + +P KAL +Y G+ PGDL+FNKGDII+LR Sbjct: 96 LQDGRKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLR 155 Query: 225 RKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPPQGKALYDFEM--KDKDQDKDCLTFT 282 R++DE WY GE++G G PAS ++ I+ LP PP +ALY+F++ KDK +++DCLTF Sbjct: 156 RQLDENWYQGEINGISGNFPASSVEVIKQLPQPPPLCRALYNFDLRGKDKSENQDCLTFL 215 Query: 283 KDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLP 342 KD+I+TV+ RVDENWAEG LGDK+GIFP+L+VE N +A+ L+E +K ++ + N SL Sbjct: 216 KDDIITVISRVDENWAEGKLGDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTK-NLSLV 274 Query: 343 SDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSF-TALSVTHRSSQAASHRHSM 401 S SS G S +R ++ + S TAL+ +R + S RH + Sbjct: 275 SS-------------SSRGNTSTLRRGPGSRRKVPGQFSITTALNTLNRMVHSPSGRHMV 321 Query: 402 EISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPK 461 EIS PVLISSS+P + + A + P+ V + P V S + + Sbjct: 322 EISTPVLISSSNPSVITQPMEKADV----PSSCVGQVSTYHPAPVSPGHSTAVVSLPGSQ 377 Query: 462 VQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVT 521 L N+++AL++Y DEL+L KGE RVL KCQDGW +G SL TG G+FP NYV Sbjct: 378 QHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVI 437 Query: 522 PVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLAT-------ATRPALPITT 574 P+ R + + G+ TT + S+SS + +RP + Sbjct: 438 PIFRKTSSFP----------DSRSPGLYTTWTLSTSSVSSQGSISEGDPRQSRPFKSVFV 487 Query: 575 PQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSP 634 P A ++ G+ + S + S R S RP + P S Sbjct: 488 PTAIVNPVRSTAGPGTLGQGSLRKGRSSMRKNGSL---------QRPLQSGIPTLVVGSL 538 Query: 635 SRLPATSLRPH--SVVSPQHSHQPP----VQMCPRPAIPLTSAASAITPPNVSAANLNGE 688 R P LRP PQ P V+M +PA+ A + I+ S A ++ Sbjct: 539 RRSPTMVLRPQQFQFYQPQGIPSSPSAVVVEMGSKPALTGEPALTCIS--RGSEARIHSA 596 Query: 689 AG------------GGPIGVLSTSSPTNTGCKLDEKKSE-KKEKKSGLLKLLAGASTKKK 735 A P+ S+P + K + ++ +K+ K+ + + TK Sbjct: 597 ASSLIMEDKEIPIKSEPLPKPPASAPPSILVKPENSRNGIEKQVKTVRFQNYSPPPTKHY 656 Query: 736 SRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIH 770 + P S P + ++GPE++ L H Sbjct: 657 TSHPTSGKPEQPATLKASQPEAASLGPEMTVLFAH 691 Score = 41.2 bits (95), Expect = 0.004 Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 14/97 (14%) Query: 793 RKAGSLDLNFTSPSRQAPLSMAAIRPEP-KLLPRERY--------RVVVSYPPQSEAEIE 843 R+ G++ L SR P + A P +L+P R + + +Y Q+ ++ Sbjct: 89 RRPGTMTLQDGRKSRTNPRRLQA---SPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLR 145 Query: 844 LKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 +GDI+ + ++ ++ WY+G + NG +G FP S VE Sbjct: 146 FNKGDIILLRRQLDENWYQGEI--NGISGNFPASSVE 180 Score = 40.0 bits (92), Expect = 0.010 Identities = 18/47 (38%), Positives = 28/47 (59%) Query: 833 SYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFV 879 SY E++L++G+ V V K +DGW +G GR G+FP ++V Sbjct: 390 SYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436 >gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo sapiens] Length = 1151 Score = 139 bits (351), Expect = 9e-33 Identities = 108/351 (30%), Positives = 166/351 (47%), Gaps = 49/351 (13%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259 +A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P Sbjct: 821 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 880 Query: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLG--DKIG 307 + G+A+ F Q + ++F K E +T+LR+VDENW EG + + G Sbjct: 881 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 938 Query: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVS 364 IFP+ YV++ K ++ MD P +S PS S A+ +P P SG Sbjct: 939 IFPITYVDVIKRPLVKNPVDYMDLPF--------SSSPSRS---ATASPQPWREESGQYE 987 Query: 365 ------AFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAA 418 A +R G K +KK + L + ++ + +++ P + R Sbjct: 988 RKAERGAGERGPGGPKISKK----SCLKPSDVVRCLSTEQRLSDLNTP-----EESRPGK 1038 Query: 419 RIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGE----QGTPPKVQLPLNV--YLAL 472 +G S A T+ + A R S + + TP + Q ++ Y AL Sbjct: 1039 PLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQAL 1098 Query: 473 YAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523 Y+Y PQ DELEL G++ V+EKC DGWF G S RT G FPGNYV P+ Sbjct: 1099 YSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149 Score = 59.3 bits (142), Expect = 2e-08 Identities = 25/53 (47%), Positives = 40/53 (75%) Query: 828 YRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 Y+ + SY PQ++ E+EL++GDIV V +K +DGW+ GT +R + G FPG++V+ Sbjct: 1095 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1147 Score = 45.8 bits (107), Expect = 2e-04 Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%) Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E Sbjct: 821 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 870 Score = 37.0 bits (84), Expect = 0.081 Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 1/80 (1%) Query: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505 +P A ++ TP +V L +A + + E+ KGE +L + + W++G Sbjct: 872 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 930 Query: 506 SLRTGVSGVFPGNYVTPVSR 525 T G+FP YV + R Sbjct: 931 IPGTSRQGIFPITYVDVIKR 950 Score = 33.1 bits (74), Expect = 1.2 Identities = 10/43 (23%), Positives = 28/43 (65%) Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 ++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+ Sbjct: 904 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 946 >gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo sapiens] Length = 671 Score = 134 bits (338), Expect = 3e-31 Identities = 112/423 (26%), Positives = 178/423 (42%), Gaps = 73/423 (17%) Query: 122 RQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTP------GSPVFLSAAAGSTA 175 + P +P PPA P S++ A G A +P GSP FL Sbjct: 301 KSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSP-FLGRRDFVYP 359 Query: 176 GSLRELATSRT--APAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYH 233 S R+ + S +PA + + + ++ + P +L KGDI+ + ++VD+ W Sbjct: 360 SSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLE 419 Query: 234 GELHGTQGFLPASYIQCIQ----PLPHAPP------QGKALYDFEMKDKDQDKDCLTFTK 283 GE HG G PA+Y++ + P P PP G+A+ + K + + L+F K Sbjct: 420 GEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVE--LSFRK 477 Query: 284 DEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASL 341 E + ++R+V+ENW EG + + GIFP YV+++ + + D P L Sbjct: 478 GEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGP----------QL 527 Query: 342 PSDSGAVASVAPSPTLSSSGAVSAFQRRVD-GKKNTKKRHSFTALSVTHRSSQAASHRHS 400 P+ A+ + SS A+ + +D G + + +R F + + + + Sbjct: 528 PTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGF-----SFPTQEPRPQTQN 582 Query: 401 MEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPP 460 + P L S P +G +P Sbjct: 583 LGTPGPALSHSRGPSHPLDLG----------------------------------TSSPN 608 Query: 461 KVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520 Q+ Y A+Y Y+PQ DELEL +G+ V+++C DGWF G S RT G FPGNYV Sbjct: 609 TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668 Query: 521 TPV 523 PV Sbjct: 669 APV 671 Score = 58.9 bits (141), Expect = 2e-08 Identities = 27/70 (38%), Positives = 41/70 (58%) Query: 810 PLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNG 869 PL + P + YR + Y PQ+E E+EL+EGD V V ++ +DGW+ G +R Sbjct: 599 PLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQ 658 Query: 870 RTGLFPGSFV 879 + G FPG++V Sbjct: 659 KFGTFPGNYV 668 Score = 49.3 bits (116), Expect = 2e-05 Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 9/89 (10%) Query: 796 GSLDLNFTSPSRQAPLSMA----AIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVF 851 G D + S +R S A R E K R+ R+ + QS E+ L++GDIV+ Sbjct: 352 GRRDFVYPSSTRDPSASNGGGSPARREEKK---RKAARLKFDFQAQSPKELTLQKGDIVY 408 Query: 852 VHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 +HK+ + W +G + +GR G+FP ++VE Sbjct: 409 IHKEVDKNWLEG--EHHGRLGIFPANYVE 435 Score = 48.1 bits (113), Expect = 4e-05 Identities = 47/185 (25%), Positives = 67/185 (36%), Gaps = 16/185 (8%) Query: 459 PPKVQ-LPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPG 517 PP Q L +A Y +K EL KGE ++ K + W++G TG G+FP Sbjct: 448 PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPA 507 Query: 518 NYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGS----------LSSLATATR 567 +YV VSR P + L + HP S S L + R Sbjct: 508 SYV-QVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRR 566 Query: 568 PALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSP 627 T + Q P G L HS P+ + T++ + +Q P + Sbjct: 567 TGFSFPTQEPRPQTQNLGTP-GPALSHSRGPSHP---LDLGTSSPNTSQIHWTPYRAMYQ 622 Query: 628 LRTQN 632 R QN Sbjct: 623 YRPQN 627 Score = 41.2 bits (95), Expect = 0.004 Identities = 26/93 (27%), Positives = 46/93 (49%), Gaps = 8/93 (8%) Query: 792 HRKAGSLDLNFTS--PSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIEL--KEG 847 H + G N+ P+ + P I+P P E V Y + + E+EL ++G Sbjct: 423 HGRLGIFPANYVEVLPADEIP---KPIKP-PTYQVLEYGEAVAQYTFKGDLEVELSFRKG 478 Query: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 + + + +K + WY+G + GR G+FP S+V+ Sbjct: 479 EHICLIRKVNENWYEGRITGTGRQGIFPASYVQ 511 Score = 33.5 bits (75), Expect = 0.89 Identities = 17/57 (29%), Positives = 28/57 (49%), Gaps = 4/57 (7%) Query: 473 YAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNY--VTPVSRVP 527 + ++ Q EL L KG++ + ++ W +G G G+FP NY V P +P Sbjct: 389 FDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGE--HHGRLGIFPANYVEVLPADEIP 443 >gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo sapiens] Length = 329 Score = 128 bits (321), Expect = 3e-29 Identities = 93/350 (26%), Positives = 152/350 (43%), Gaps = 64/350 (18%) Query: 187 APAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPAS 246 +PA + + + ++ + P +L KGDI+ + ++VD+ W GE HG G PA+ Sbjct: 31 SPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPAN 90 Query: 247 YIQCIQ----PLPHAPP------QGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDEN 296 Y++ + P P PP G+A+ + K + + L+F K E + ++R+V+EN Sbjct: 91 YVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVE--LSFRKGEHICLIRKVNEN 148 Query: 297 WAEGML--GDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPS 354 W EG + + GIFP YV+++ + + D P LP+ A+ + Sbjct: 149 WYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGP----------QLPTSPRLTAAARSA 198 Query: 355 PTLSSSGAVSAFQRRVD-GKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSD 413 SS A+ + +D G + + +R F + + + ++ P L S Sbjct: 199 RHPSSPSALRSPADPIDLGGQTSPRRTGF-----SFPTQEPRPQTQNLGTPGPALSHSRG 253 Query: 414 PRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALY 473 P +G +P Q+ Y A+Y Sbjct: 254 PSHPLDLG----------------------------------TSSPNTSQIHWTPYRAMY 279 Query: 474 AYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523 Y+PQ DELEL +G+ V+++C DGWF G S RT G FPGNYV PV Sbjct: 280 QYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329 Score = 58.9 bits (141), Expect = 2e-08 Identities = 27/70 (38%), Positives = 41/70 (58%) Query: 810 PLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNG 869 PL + P + YR + Y PQ+E E+EL+EGD V V ++ +DGW+ G +R Sbjct: 257 PLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQ 316 Query: 870 RTGLFPGSFV 879 + G FPG++V Sbjct: 317 KFGTFPGNYV 326 Score = 49.3 bits (116), Expect = 2e-05 Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 9/89 (10%) Query: 796 GSLDLNFTSPSRQAPLSMA----AIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVF 851 G D + S +R S A R E K R+ R+ + QS E+ L++GDIV+ Sbjct: 10 GRRDFVYPSSTRDPSASNGGGSPARREEKK---RKAARLKFDFQAQSPKELTLQKGDIVY 66 Query: 852 VHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 +HK+ + W +G + +GR G+FP ++VE Sbjct: 67 IHKEVDKNWLEG--EHHGRLGIFPANYVE 93 Score = 48.1 bits (113), Expect = 4e-05 Identities = 47/185 (25%), Positives = 67/185 (36%), Gaps = 16/185 (8%) Query: 459 PPKVQ-LPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPG 517 PP Q L +A Y +K EL KGE ++ K + W++G TG G+FP Sbjct: 106 PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPA 165 Query: 518 NYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGS----------LSSLATATR 567 +YV VSR P + L + HP S S L + R Sbjct: 166 SYV-QVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRR 224 Query: 568 PALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSP 627 T + Q P G L HS P+ + T++ + +Q P + Sbjct: 225 TGFSFPTQEPRPQTQNLGTP-GPALSHSRGPSHP---LDLGTSSPNTSQIHWTPYRAMYQ 280 Query: 628 LRTQN 632 R QN Sbjct: 281 YRPQN 285 Score = 41.2 bits (95), Expect = 0.004 Identities = 26/93 (27%), Positives = 46/93 (49%), Gaps = 8/93 (8%) Query: 792 HRKAGSLDLNFTS--PSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIEL--KEG 847 H + G N+ P+ + P I+P P E V Y + + E+EL ++G Sbjct: 81 HGRLGIFPANYVEVLPADEIP---KPIKP-PTYQVLEYGEAVAQYTFKGDLEVELSFRKG 136 Query: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 + + + +K + WY+G + GR G+FP S+V+ Sbjct: 137 EHICLIRKVNENWYEGRITGTGRQGIFPASYVQ 169 Score = 34.3 bits (77), Expect = 0.52 Identities = 20/81 (24%), Positives = 37/81 (45%), Gaps = 3/81 (3%) Query: 170 AAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDE 229 A + G L ++P PY +A+Y Y + +L+ +GD + + ++ D+ Sbjct: 247 ALSHSRGPSHPLDLGTSSPNTSQIHWTPY-RAMYQYRPQNEDELELREGDRVDVMQQCDD 305 Query: 230 QWYHGELHGTQ--GFLPASYI 248 W+ G TQ G P +Y+ Sbjct: 306 GWFVGVSRRTQKFGTFPGNYV 326 Score = 33.5 bits (75), Expect = 0.89 Identities = 17/57 (29%), Positives = 28/57 (49%), Gaps = 4/57 (7%) Query: 473 YAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNY--VTPVSRVP 527 + ++ Q EL L KG++ + ++ W +G G G+FP NY V P +P Sbjct: 47 FDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGE--HHGRLGIFPANYVEVLPADEIP 101 >gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo sapiens] Length = 905 Score = 92.4 bits (228), Expect = 2e-18 Identities = 84/274 (30%), Positives = 124/274 (45%), Gaps = 32/274 (11%) Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321 +A +DF K Q L K +I+ + +++D+NW EG ++GIFP Y+EL A+ Sbjct: 650 RAKFDF----KAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 705 Query: 322 QLIEMDKPCPAAASSCNASLPS-----DSGAVASVAPSPTLSSSGAVSA--FQRRVDGKK 374 + + K P ++ D+ S ++ V ++ R+ G Sbjct: 706 KA-QPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG-- 762 Query: 375 NTKKRHSF--TALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSC-AAP 431 T ++ F T + V R + M++ SSS R+A L+H S A P Sbjct: 763 -TSRQGIFPITYVDVIKRPL-VKNPVDYMDLP----FSSSPSRSATASPQLSHHSLRAGP 816 Query: 432 TQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNV--YLALYAYKPQKSDELELHKGE 489 S + P A R TP + Q ++ Y ALY+Y PQ DELEL G+ Sbjct: 817 DLTESEKSYVQPQAQQRRV-------TPDRSQTSQDLFSYQALYSYIPQNDDELELRDGD 869 Query: 490 MYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523 + V+EKC DGWF G S RT G FPGNYV P+ Sbjct: 870 IVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 903 Score = 88.6 bits (218), Expect = 2e-17 Identities = 63/205 (30%), Positives = 101/205 (49%), Gaps = 21/205 (10%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259 +A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P Sbjct: 650 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 709 Query: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307 + G+A+ F Q + ++F K E +T+LR+VDENW EG + + G Sbjct: 710 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 767 Query: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAV- 363 IFP+ YV++ K ++ MD P ++ S + P S P T S V Sbjct: 768 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQ 827 Query: 364 -SAFQRRV--DGKKNTKKRHSFTAL 385 A QRRV D + ++ S+ AL Sbjct: 828 PQAQQRRVTPDRSQTSQDLFSYQAL 852 Score = 59.3 bits (142), Expect = 2e-08 Identities = 25/53 (47%), Positives = 40/53 (75%) Query: 828 YRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 Y+ + SY PQ++ E+EL++GDIV V +K +DGW+ GT +R + G FPG++V+ Sbjct: 849 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 901 Score = 45.8 bits (107), Expect = 2e-04 Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%) Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E Sbjct: 650 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 699 Score = 41.2 bits (95), Expect = 0.004 Identities = 42/162 (25%), Positives = 59/162 (36%), Gaps = 27/162 (16%) Query: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505 +P A ++ TP +V L +A + + E+ KGE +L + + W++G Sbjct: 701 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 759 Query: 506 SLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMH-PGSGSLSSLAT 564 T G+FP YV + R PL K M P S S S AT Sbjct: 760 IPGTSRQGIFPITYVDVIKR-----------------PLVKNPVDYMDLPFSSSPSRSAT 802 Query: 565 ATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARST 606 A +PQ A P + QP A Q R T Sbjct: 803 A--------SPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVT 836 Score = 35.8 bits (81), Expect = 0.18 Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249 +ALYSY + +L+ GDI+ + K D+ W+ G T+ G P +Y++ Sbjct: 850 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 901 Score = 33.1 bits (74), Expect = 1.2 Identities = 10/43 (23%), Positives = 28/43 (65%) Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 ++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+ Sbjct: 733 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 775 >gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo sapiens] Length = 492 Score = 90.9 bits (224), Expect = 5e-18 Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%) Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321 KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE Sbjct: 261 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 310 Query: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381 +L +K PA P+ G + ++ V R+ D K+ Sbjct: 311 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 365 Query: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439 + ++R + + V + + + A D + H + +SS+ Sbjct: 366 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 420 Query: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499 P GE + ALY Y P+ DELEL + ++ V+EKC D Sbjct: 421 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 468 Query: 500 GWFKGASLRTGVSGVFPGNYV 520 GWF G S RT G FPGNYV Sbjct: 469 GWFVGTSRRTKFFGTFPGNYV 489 Score = 89.7 bits (221), Expect = 1e-17 Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%) Query: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183 R R + P PP R + QSA+ T G PGS L+ + S++ S A Sbjct: 173 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 226 Query: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225 R +P + + L G KA+Y ++ + +L F KGD + + R Sbjct: 227 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 286 Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272 K+D+ WY GE HG G P SY++ + P A P + A Y+F Sbjct: 287 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 346 Query: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328 + L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D Sbjct: 347 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 402 Query: 329 PCPAAASS 336 P P + SS Sbjct: 403 PIPHSYSS 410 Score = 54.7 bits (130), Expect = 4e-07 Identities = 22/55 (40%), Positives = 39/55 (70%) Query: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+ Sbjct: 436 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490 Score = 51.2 bits (121), Expect = 4e-06 Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%) Query: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469 +SS P + +R D ++ S ST T + R+A +GTP K +LP Sbjct: 215 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 261 Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526 A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP + Sbjct: 262 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 318 Query: 527 PAGGAGPPRNNVVGGSPLAK 546 PP G +AK Sbjct: 319 QPARPPPPAQPGEIGEAIAK 338 Score = 50.8 bits (120), Expect = 5e-06 Identities = 67/290 (23%), Positives = 109/290 (37%), Gaps = 49/290 (16%) Query: 608 STAAHSAAQAQD-RPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAI 666 S +H AA+ Q RP +S + NSP+ S S V P H P + PR Sbjct: 53 SAQSHPAAKTQTYRP---LSKSHSDNSPNAFKDAS----SPVPPPHVPPPVPPLRPRDRS 105 Query: 667 PLTSAASAITPPN--VSAANLNGEAGG------GPIGVLSTSSPTNTGCKLDEKKSEKKE 718 ++ PP+ V E G +L P + ++ E+ Sbjct: 106 --STEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPM 163 Query: 719 KKSGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRA----G 774 + + + +K+ +S P+V P +G + +S + GR Sbjct: 164 SSASM-----ASDFRKRRKSEPAVGPPR------------GLGDQSASRTSPGRVDLPGS 206 Query: 775 SCPIESEMQGAMGMEPLHRK----AGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRV 830 S + + P K S T R AP PE + LP + Sbjct: 207 STTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT-PEKEKLPA---KA 262 Query: 831 VVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 V + Q+ E+ K+GD V++ +K + WY+G + +GR G+FP S+VE Sbjct: 263 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVE 310 Score = 48.5 bits (114), Expect = 3e-05 Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%) Query: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838 E E G +G+ P+ S T P + P RP P P E + Y + Sbjct: 294 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 343 Query: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 + +EL ++GD V + K+ + WY+G + R G+FP S+VE Sbjct: 344 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 387 Score = 39.7 bits (91), Expect = 0.012 Identities = 21/76 (27%), Positives = 34/76 (44%) Query: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518 PP + +A Y + + EL L KG+ +L++ W++G T G+FP + Sbjct: 325 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 384 Query: 519 YVTPVSRVPAGGAGPP 534 YV V + G P Sbjct: 385 YVEVVKKNTKGAEDYP 400 Score = 34.3 bits (77), Expect = 0.52 Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249 +ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++ Sbjct: 439 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490 >gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo sapiens] Length = 1004 Score = 90.9 bits (224), Expect = 5e-18 Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%) Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321 KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE Sbjct: 773 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 822 Query: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381 +L +K PA P+ G + ++ V R+ D K+ Sbjct: 823 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 877 Query: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439 + ++R + + V + + + A D + H + +SS+ Sbjct: 878 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 932 Query: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499 P GE + ALY Y P+ DELEL + ++ V+EKC D Sbjct: 933 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 980 Query: 500 GWFKGASLRTGVSGVFPGNYV 520 GWF G S RT G FPGNYV Sbjct: 981 GWFVGTSRRTKFFGTFPGNYV 1001 Score = 81.6 bits (200), Expect = 3e-15 Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 21/154 (13%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259 KA+Y ++ + +L F KGD + + RK+D+ WY GE HG G P SY++ + P A P Sbjct: 773 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 832 Query: 260 -------------QGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GD 304 + A Y+F + L+ K + + +L+RVD+NW EG + + Sbjct: 833 ARPPPPAQPGEIGEAIAKYNFNADTNVE----LSLRKGDRVILLKRVDQNWYEGKIPGTN 888 Query: 305 KIGIFPLLYVELNDSAKQLIE--MDKPCPAAASS 336 + GIFP+ YVE+ + E D P P + SS Sbjct: 889 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSS 922 Score = 54.7 bits (130), Expect = 4e-07 Identities = 22/55 (40%), Positives = 39/55 (70%) Query: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+ Sbjct: 948 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002 Score = 53.5 bits (127), Expect = 8e-07 Identities = 42/179 (23%), Positives = 74/179 (41%), Gaps = 47/179 (26%) Query: 180 ELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGT 239 E A P P + A Y++ +L KGD ++L ++VD+ WY G++ GT Sbjct: 828 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 887 Query: 240 --QGFLPASYIQCIQ------------PLPHA------------PPQG------------ 261 QG P SY++ ++ P+PH+ PQ Sbjct: 888 NRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 947 Query: 262 ---KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDK--IGIFPLLYVE 315 +ALY++ +++D+ L + +++ V+ + D+ W G G FP YV+ Sbjct: 948 EPFQALYNYTPRNEDE----LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002 Score = 52.0 bits (123), Expect = 2e-06 Identities = 46/144 (31%), Positives = 66/144 (45%), Gaps = 17/144 (11%) Query: 414 PRAAA-RIGDLAHLSC-------AAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLP 465 PR+A+ + D A+ SC A ++ S ST T + R+A +GTP K +LP Sbjct: 713 PRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLP 771 Query: 466 LNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TP 522 A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP Sbjct: 772 AK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTP 826 Query: 523 VSRVPAGGAGPPRNNVVGGSPLAK 546 + PP G +AK Sbjct: 827 PEKAQPARPPPPAQPGEIGEAIAK 850 Score = 49.3 bits (116), Expect = 2e-05 Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 6/84 (7%) Query: 797 SLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR 856 S T R AP PE + LP + V + Q+ E+ K+GD V++ +K Sbjct: 745 SYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSFKKGDTVYILRKI 800 Query: 857 EDGWYKGTLQRNGRTGLFPGSFVE 880 + WY+G + +GR G+FP S+VE Sbjct: 801 DQNWYEG--EHHGRVGIFPISYVE 822 Score = 48.5 bits (114), Expect = 3e-05 Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%) Query: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838 E E G +G+ P+ S T P + P RP P P E + Y + Sbjct: 806 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 855 Query: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 + +EL ++GD V + K+ + WY+G + R G+FP S+VE Sbjct: 856 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 899 Score = 39.7 bits (91), Expect = 0.012 Identities = 21/76 (27%), Positives = 34/76 (44%) Query: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518 PP + +A Y + + EL L KG+ +L++ W++G T G+FP + Sbjct: 837 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 896 Query: 519 YVTPVSRVPAGGAGPP 534 YV V + G P Sbjct: 897 YVEVVKKNTKGAEDYP 912 >gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo sapiens] Length = 824 Score = 90.9 bits (224), Expect = 5e-18 Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%) Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321 KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE Sbjct: 593 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 642 Query: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381 +L +K PA P+ G + ++ V R+ D K+ Sbjct: 643 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 697 Query: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439 + ++R + + V + + + A D + H + +SS+ Sbjct: 698 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 752 Query: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499 P GE + ALY Y P+ DELEL + ++ V+EKC D Sbjct: 753 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 800 Query: 500 GWFKGASLRTGVSGVFPGNYV 520 GWF G S RT G FPGNYV Sbjct: 801 GWFVGTSRRTKFFGTFPGNYV 821 Score = 89.7 bits (221), Expect = 1e-17 Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%) Query: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183 R R + P PP R + QSA+ T G PGS L+ + S++ S A Sbjct: 505 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 558 Query: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225 R +P + + L G KA+Y ++ + +L F KGD + + R Sbjct: 559 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 618 Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272 K+D+ WY GE HG G P SY++ + P A P + A Y+F Sbjct: 619 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 678 Query: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328 + L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D Sbjct: 679 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 734 Query: 329 PCPAAASS 336 P P + SS Sbjct: 735 PIPHSYSS 742 Score = 54.7 bits (130), Expect = 4e-07 Identities = 22/55 (40%), Positives = 39/55 (70%) Query: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+ Sbjct: 768 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822 Score = 52.8 bits (125), Expect = 1e-06 Identities = 62/276 (22%), Positives = 101/276 (36%), Gaps = 41/276 (14%) Query: 613 SAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAA 672 S Q + P +P P R P +S R V S PP PR P S+ Sbjct: 400 SILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTG---SPSPP----PRSGAPTPSSR 452 Query: 673 SAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGAST 732 + P GV + +S + ++ E+ + + + Sbjct: 453 APALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSI---DRSLERPMSSASM-----ASDF 504 Query: 733 KKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRA----GSCPIESEMQGAMGM 788 +K+ +S P+V P +G + +S + GR S + + Sbjct: 505 RKRRKSEPAVGPPR------------GLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPS 552 Query: 789 EPLHRK----AGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIEL 844 P K S T R AP PE + LP + V + Q+ E+ Sbjct: 553 SPSRAKDRESPRSYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSF 608 Query: 845 KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 K+GD V++ +K + WY+G + +GR G+FP S+VE Sbjct: 609 KKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVE 642 Score = 51.2 bits (121), Expect = 4e-06 Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%) Query: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469 +SS P + +R D ++ S ST T + R+A +GTP K +LP Sbjct: 547 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 593 Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526 A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP + Sbjct: 594 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 650 Query: 527 PAGGAGPPRNNVVGGSPLAK 546 PP G +AK Sbjct: 651 QPARPPPPAQPGEIGEAIAK 670 Score = 48.5 bits (114), Expect = 3e-05 Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%) Query: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838 E E G +G+ P+ S T P + P RP P P E + Y + Sbjct: 626 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 675 Query: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 + +EL ++GD V + K+ + WY+G + R G+FP S+VE Sbjct: 676 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 719 Score = 39.7 bits (91), Expect = 0.012 Identities = 21/76 (27%), Positives = 34/76 (44%) Query: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518 PP + +A Y + + EL L KG+ +L++ W++G T G+FP + Sbjct: 657 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 716 Query: 519 YVTPVSRVPAGGAGPP 534 YV V + G P Sbjct: 717 YVEVVKKNTKGAEDYP 732 Score = 34.3 bits (77), Expect = 0.52 Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249 +ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++ Sbjct: 771 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822 >gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo sapiens] Length = 661 Score = 90.9 bits (224), Expect = 5e-18 Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%) Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321 KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE Sbjct: 430 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 479 Query: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381 +L +K PA P+ G + ++ V R+ D K+ Sbjct: 480 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 534 Query: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439 + ++R + + V + + + A D + H + +SS+ Sbjct: 535 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 589 Query: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499 P GE + ALY Y P+ DELEL + ++ V+EKC D Sbjct: 590 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 637 Query: 500 GWFKGASLRTGVSGVFPGNYV 520 GWF G S RT G FPGNYV Sbjct: 638 GWFVGTSRRTKFFGTFPGNYV 658 Score = 89.7 bits (221), Expect = 1e-17 Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%) Query: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183 R R + P PP R + QSA+ T G PGS L+ + S++ S A Sbjct: 342 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 395 Query: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225 R +P + + L G KA+Y ++ + +L F KGD + + R Sbjct: 396 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 455 Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272 K+D+ WY GE HG G P SY++ + P A P + A Y+F Sbjct: 456 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 515 Query: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328 + L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D Sbjct: 516 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 571 Query: 329 PCPAAASS 336 P P + SS Sbjct: 572 PIPHSYSS 579 Score = 54.7 bits (130), Expect = 4e-07 Identities = 22/55 (40%), Positives = 39/55 (70%) Query: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+ Sbjct: 605 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 659 Score = 51.2 bits (121), Expect = 4e-06 Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%) Query: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469 +SS P + +R D ++ S ST T + R+A +GTP K +LP Sbjct: 384 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 430 Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526 A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP + Sbjct: 431 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 487 Query: 527 PAGGAGPPRNNVVGGSPLAK 546 PP G +AK Sbjct: 488 QPARPPPPAQPGEIGEAIAK 507 Score = 49.3 bits (116), Expect = 2e-05 Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 6/84 (7%) Query: 797 SLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR 856 S T R AP PE + LP + V + Q+ E+ K+GD V++ +K Sbjct: 402 SYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSFKKGDTVYILRKI 457 Query: 857 EDGWYKGTLQRNGRTGLFPGSFVE 880 + WY+G + +GR G+FP S+VE Sbjct: 458 DQNWYEG--EHHGRVGIFPISYVE 479 Score = 48.5 bits (114), Expect = 3e-05 Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%) Query: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838 E E G +G+ P+ S T P + P RP P P E + Y + Sbjct: 463 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 512 Query: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 + +EL ++GD V + K+ + WY+G + R G+FP S+VE Sbjct: 513 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 556 Score = 39.7 bits (91), Expect = 0.012 Identities = 21/76 (27%), Positives = 34/76 (44%) Query: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518 PP + +A Y + + EL L KG+ +L++ W++G T G+FP + Sbjct: 494 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 553 Query: 519 YVTPVSRVPAGGAGPP 534 YV V + G P Sbjct: 554 YVEVVKKNTKGAEDYP 569 Score = 34.3 bits (77), Expect = 0.52 Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249 +ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++ Sbjct: 608 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 659 >gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo sapiens] Length = 731 Score = 90.9 bits (224), Expect = 5e-18 Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%) Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321 KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE Sbjct: 500 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 549 Query: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381 +L +K PA P+ G + ++ V R+ D K+ Sbjct: 550 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 604 Query: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439 + ++R + + V + + + A D + H + +SS+ Sbjct: 605 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 659 Query: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499 P GE + ALY Y P+ DELEL + ++ V+EKC D Sbjct: 660 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 707 Query: 500 GWFKGASLRTGVSGVFPGNYV 520 GWF G S RT G FPGNYV Sbjct: 708 GWFVGTSRRTKFFGTFPGNYV 728 Score = 89.7 bits (221), Expect = 1e-17 Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%) Query: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183 R R + P PP R + QSA+ T G PGS L+ + S++ S A Sbjct: 412 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 465 Query: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225 R +P + + L G KA+Y ++ + +L F KGD + + R Sbjct: 466 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 525 Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272 K+D+ WY GE HG G P SY++ + P A P + A Y+F Sbjct: 526 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 585 Query: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328 + L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D Sbjct: 586 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 641 Query: 329 PCPAAASS 336 P P + SS Sbjct: 642 PIPHSYSS 649 Score = 54.7 bits (130), Expect = 4e-07 Identities = 22/55 (40%), Positives = 39/55 (70%) Query: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+ Sbjct: 675 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729 Score = 52.8 bits (125), Expect = 1e-06 Identities = 62/276 (22%), Positives = 101/276 (36%), Gaps = 41/276 (14%) Query: 613 SAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAA 672 S Q + P +P P R P +S R V S PP PR P S+ Sbjct: 307 SILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTG---SPSPP----PRSGAPTPSSR 359 Query: 673 SAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGAST 732 + P GV + +S + ++ E+ + + + Sbjct: 360 APALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSI---DRSLERPMSSASM-----ASDF 411 Query: 733 KKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRA----GSCPIESEMQGAMGM 788 +K+ +S P+V P +G + +S + GR S + + Sbjct: 412 RKRRKSEPAVGPPR------------GLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPS 459 Query: 789 EPLHRK----AGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIEL 844 P K S T R AP PE + LP + V + Q+ E+ Sbjct: 460 SPSRAKDRESPRSYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSF 515 Query: 845 KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 K+GD V++ +K + WY+G + +GR G+FP S+VE Sbjct: 516 KKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVE 549 Score = 51.2 bits (121), Expect = 4e-06 Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%) Query: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469 +SS P + +R D ++ S ST T + R+A +GTP K +LP Sbjct: 454 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 500 Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526 A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP + Sbjct: 501 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 557 Query: 527 PAGGAGPPRNNVVGGSPLAK 546 PP G +AK Sbjct: 558 QPARPPPPAQPGEIGEAIAK 577 Score = 48.5 bits (114), Expect = 3e-05 Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%) Query: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838 E E G +G+ P+ S T P + P RP P P E + Y + Sbjct: 533 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 582 Query: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 + +EL ++GD V + K+ + WY+G + R G+FP S+VE Sbjct: 583 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 626 Score = 39.7 bits (91), Expect = 0.012 Identities = 21/76 (27%), Positives = 34/76 (44%) Query: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518 PP + +A Y + + EL L KG+ +L++ W++G T G+FP + Sbjct: 564 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 623 Query: 519 YVTPVSRVPAGGAGPP 534 YV V + G P Sbjct: 624 YVEVVKKNTKGAEDYP 639 Score = 34.3 bits (77), Expect = 0.52 Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249 +ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++ Sbjct: 678 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729 >gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo sapiens] Length = 644 Score = 90.9 bits (224), Expect = 5e-18 Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%) Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321 KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE Sbjct: 413 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 462 Query: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381 +L +K PA P+ G + ++ V R+ D K+ Sbjct: 463 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 517 Query: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439 + ++R + + V + + + A D + H + +SS+ Sbjct: 518 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 572 Query: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499 P GE + ALY Y P+ DELEL + ++ V+EKC D Sbjct: 573 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 620 Query: 500 GWFKGASLRTGVSGVFPGNYV 520 GWF G S RT G FPGNYV Sbjct: 621 GWFVGTSRRTKFFGTFPGNYV 641 Score = 89.7 bits (221), Expect = 1e-17 Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%) Query: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183 R R + P PP R + QSA+ T G PGS L+ + S++ S A Sbjct: 325 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 378 Query: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225 R +P + + L G KA+Y ++ + +L F KGD + + R Sbjct: 379 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 438 Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272 K+D+ WY GE HG G P SY++ + P A P + A Y+F Sbjct: 439 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 498 Query: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328 + L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D Sbjct: 499 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 554 Query: 329 PCPAAASS 336 P P + SS Sbjct: 555 PIPHSYSS 562 Score = 54.7 bits (130), Expect = 4e-07 Identities = 22/55 (40%), Positives = 39/55 (70%) Query: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+ Sbjct: 588 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642 Score = 51.2 bits (121), Expect = 4e-06 Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%) Query: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469 +SS P + +R D ++ S ST T + R+A +GTP K +LP Sbjct: 367 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 413 Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526 A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP + Sbjct: 414 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 470 Query: 527 PAGGAGPPRNNVVGGSPLAK 546 PP G +AK Sbjct: 471 QPARPPPPAQPGEIGEAIAK 490 Score = 50.8 bits (120), Expect = 5e-06 Identities = 67/290 (23%), Positives = 109/290 (37%), Gaps = 49/290 (16%) Query: 608 STAAHSAAQAQD-RPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAI 666 S +H AA+ Q RP +S + NSP+ S S V P H P + PR Sbjct: 205 SAQSHPAAKTQTYRP---LSKSHSDNSPNAFKDAS----SPVPPPHVPPPVPPLRPRDRS 257 Query: 667 PLTSAASAITPPN--VSAANLNGEAGG------GPIGVLSTSSPTNTGCKLDEKKSEKKE 718 ++ PP+ V E G +L P + ++ E+ Sbjct: 258 --STEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPM 315 Query: 719 KKSGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRA----G 774 + + + +K+ +S P+V P +G + +S + GR Sbjct: 316 SSASM-----ASDFRKRRKSEPAVGPPR------------GLGDQSASRTSPGRVDLPGS 358 Query: 775 SCPIESEMQGAMGMEPLHRK----AGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRV 830 S + + P K S T R AP PE + LP + Sbjct: 359 STTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT-PEKEKLPA---KA 414 Query: 831 VVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 V + Q+ E+ K+GD V++ +K + WY+G + +GR G+FP S+VE Sbjct: 415 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVE 462 Score = 48.5 bits (114), Expect = 3e-05 Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%) Query: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838 E E G +G+ P+ S T P + P RP P P E + Y + Sbjct: 446 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 495 Query: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 + +EL ++GD V + K+ + WY+G + R G+FP S+VE Sbjct: 496 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 539 Score = 39.7 bits (91), Expect = 0.012 Identities = 21/76 (27%), Positives = 34/76 (44%) Query: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518 PP + +A Y + + EL L KG+ +L++ W++G T G+FP + Sbjct: 477 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 536 Query: 519 YVTPVSRVPAGGAGPP 534 YV V + G P Sbjct: 537 YVEVVKKNTKGAEDYP 552 Score = 34.3 bits (77), Expect = 0.52 Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249 +ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++ Sbjct: 591 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642 >gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo sapiens] Length = 1100 Score = 90.9 bits (224), Expect = 5e-18 Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%) Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321 KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE Sbjct: 869 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 918 Query: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381 +L +K PA P+ G + ++ V R+ D K+ Sbjct: 919 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 973 Query: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439 + ++R + + V + + + A D + H + +SS+ Sbjct: 974 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 1028 Query: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499 P GE + ALY Y P+ DELEL + ++ V+EKC D Sbjct: 1029 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 1076 Query: 500 GWFKGASLRTGVSGVFPGNYV 520 GWF G S RT G FPGNYV Sbjct: 1077 GWFVGTSRRTKFFGTFPGNYV 1097 Score = 81.6 bits (200), Expect = 3e-15 Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 21/154 (13%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259 KA+Y ++ + +L F KGD + + RK+D+ WY GE HG G P SY++ + P A P Sbjct: 869 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 928 Query: 260 -------------QGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GD 304 + A Y+F + L+ K + + +L+RVD+NW EG + + Sbjct: 929 ARPPPPAQPGEIGEAIAKYNFNADTNVE----LSLRKGDRVILLKRVDQNWYEGKIPGTN 984 Query: 305 KIGIFPLLYVELNDSAKQLIE--MDKPCPAAASS 336 + GIFP+ YVE+ + E D P P + SS Sbjct: 985 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSS 1018 Score = 54.7 bits (130), Expect = 4e-07 Identities = 22/55 (40%), Positives = 39/55 (70%) Query: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+ Sbjct: 1044 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098 Score = 53.5 bits (127), Expect = 8e-07 Identities = 42/179 (23%), Positives = 74/179 (41%), Gaps = 47/179 (26%) Query: 180 ELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGT 239 E A P P + A Y++ +L KGD ++L ++VD+ WY G++ GT Sbjct: 924 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 983 Query: 240 --QGFLPASYIQCIQ------------PLPHA------------PPQG------------ 261 QG P SY++ ++ P+PH+ PQ Sbjct: 984 NRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 1043 Query: 262 ---KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDK--IGIFPLLYVE 315 +ALY++ +++D+ L + +++ V+ + D+ W G G FP YV+ Sbjct: 1044 EPFQALYNYTPRNEDE----LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098 Score = 52.0 bits (123), Expect = 2e-06 Identities = 46/144 (31%), Positives = 66/144 (45%), Gaps = 17/144 (11%) Query: 414 PRAAA-RIGDLAHLSC-------AAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLP 465 PR+A+ + D A+ SC A ++ S ST T + R+A +GTP K +LP Sbjct: 809 PRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLP 867 Query: 466 LNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TP 522 A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP Sbjct: 868 AK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTP 922 Query: 523 VSRVPAGGAGPPRNNVVGGSPLAK 546 + PP G +AK Sbjct: 923 PEKAQPARPPPPAQPGEIGEAIAK 946 Score = 49.3 bits (116), Expect = 2e-05 Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 6/84 (7%) Query: 797 SLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR 856 S T R AP PE + LP + V + Q+ E+ K+GD V++ +K Sbjct: 841 SYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSFKKGDTVYILRKI 896 Query: 857 EDGWYKGTLQRNGRTGLFPGSFVE 880 + WY+G + +GR G+FP S+VE Sbjct: 897 DQNWYEG--EHHGRVGIFPISYVE 918 Score = 48.5 bits (114), Expect = 3e-05 Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%) Query: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838 E E G +G+ P+ S T P + P RP P P E + Y + Sbjct: 902 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 951 Query: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 + +EL ++GD V + K+ + WY+G + R G+FP S+VE Sbjct: 952 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 995 Score = 39.7 bits (91), Expect = 0.012 Identities = 21/76 (27%), Positives = 34/76 (44%) Query: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518 PP + +A Y + + EL L KG+ +L++ W++G T G+FP + Sbjct: 933 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 992 Query: 519 YVTPVSRVPAGGAGPP 534 YV V + G P Sbjct: 993 YVEVVKKNTKGAEDYP 1008 >gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo sapiens] Length = 666 Score = 90.9 bits (224), Expect = 5e-18 Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%) Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321 KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE Sbjct: 435 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 484 Query: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381 +L +K PA P+ G + ++ V R+ D K+ Sbjct: 485 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 539 Query: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439 + ++R + + V + + + A D + H + +SS+ Sbjct: 540 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 594 Query: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499 P GE + ALY Y P+ DELEL + ++ V+EKC D Sbjct: 595 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 642 Query: 500 GWFKGASLRTGVSGVFPGNYV 520 GWF G S RT G FPGNYV Sbjct: 643 GWFVGTSRRTKFFGTFPGNYV 663 Score = 89.7 bits (221), Expect = 1e-17 Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%) Query: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183 R R + P PP R + QSA+ T G PGS L+ + S++ S A Sbjct: 347 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 400 Query: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225 R +P + + L G KA+Y ++ + +L F KGD + + R Sbjct: 401 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 460 Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272 K+D+ WY GE HG G P SY++ + P A P + A Y+F Sbjct: 461 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 520 Query: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328 + L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D Sbjct: 521 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 576 Query: 329 PCPAAASS 336 P P + SS Sbjct: 577 PIPHSYSS 584 Score = 54.7 bits (130), Expect = 4e-07 Identities = 22/55 (40%), Positives = 39/55 (70%) Query: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+ Sbjct: 610 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 664 Score = 51.2 bits (121), Expect = 4e-06 Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%) Query: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469 +SS P + +R D ++ S ST T + R+A +GTP K +LP Sbjct: 389 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 435 Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526 A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP + Sbjct: 436 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 492 Query: 527 PAGGAGPPRNNVVGGSPLAK 546 PP G +AK Sbjct: 493 QPARPPPPAQPGEIGEAIAK 512 Score = 49.3 bits (116), Expect = 2e-05 Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 6/84 (7%) Query: 797 SLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR 856 S T R AP PE + LP + V + Q+ E+ K+GD V++ +K Sbjct: 407 SYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSFKKGDTVYILRKI 462 Query: 857 EDGWYKGTLQRNGRTGLFPGSFVE 880 + WY+G + +GR G+FP S+VE Sbjct: 463 DQNWYEG--EHHGRVGIFPISYVE 484 Score = 48.5 bits (114), Expect = 3e-05 Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%) Query: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838 E E G +G+ P+ S T P + P RP P P E + Y + Sbjct: 468 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 517 Query: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 + +EL ++GD V + K+ + WY+G + R G+FP S+VE Sbjct: 518 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 561 Score = 39.7 bits (91), Expect = 0.012 Identities = 21/76 (27%), Positives = 34/76 (44%) Query: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518 PP + +A Y + + EL L KG+ +L++ W++G T G+FP + Sbjct: 499 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 558 Query: 519 YVTPVSRVPAGGAGPP 534 YV V + G P Sbjct: 559 YVEVVKKNTKGAEDYP 574 Score = 34.3 bits (77), Expect = 0.52 Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249 +ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++ Sbjct: 613 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 664 >gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] Length = 731 Score = 88.2 bits (217), Expect = 3e-17 Identities = 83/341 (24%), Positives = 132/341 (38%), Gaps = 71/341 (20%) Query: 197 PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLP- 255 P+ L+ + ++ DL G+I+ L K+D WY G G PA+Y++ I +P Sbjct: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 498 Query: 256 -----------HAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGD 304 H + + FE + KD L+F++ EI+ + V+E WA G + Sbjct: 499 GGNGKRECVSSHCVKGSRCVARFEY--IGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 556 Query: 305 KIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLP-----SDSGAVASVAPSPTLSS 359 + GIFPL +VE + D P + A+ + +P DSG+ + V P Sbjct: 557 RTGIFPLNFVEPVE--------DYP-TSGANVLSTKVPLKTKKEDSGSNSQVNSLPA--- 604 Query: 360 SGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAAR 419 + + HSFTA +S S + I +L R Sbjct: 605 --------------EWCEALHSFTA-----ETSDDLSFKRGDRIQ--ILERLDSDWCRGR 643 Query: 420 IGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQK 479 + D + A + + A S VP+ ALY ++ + Sbjct: 644 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAK-----------------ALYDFRGEN 686 Query: 480 SDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520 DEL G++ LE D W G + G SG+FP NY+ Sbjct: 687 EDELSFKAGDIITELESVDDDWMSGELM--GKSGIFPKNYI 725 Score = 73.2 bits (178), Expect = 1e-12 Identities = 43/126 (34%), Positives = 67/126 (53%), Gaps = 17/126 (13%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAP- 258 +AL+S+ + DL F +GD I + ++D W G L +G PA + ++P P Sbjct: 608 EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVF---VRPCPAEAK 664 Query: 259 ------PQG---KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIF 309 P+G KALYDF +++D+ L+F +I+T L VD++W G L K GIF Sbjct: 665 SMLAIVPKGRKAKALYDFRGENEDE----LSFKAGDIITELESVDDDWMSGELMGKSGIF 720 Query: 310 PLLYVE 315 P Y++ Sbjct: 721 PKNYIQ 726 Score = 57.0 bits (136), Expect = 8e-08 Identities = 92/436 (21%), Positives = 154/436 (35%), Gaps = 86/436 (19%) Query: 115 VRLLDGIRQRPRAG-TSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGS 173 VR+ + RP G T P PP + P + P L+ S P S++ Sbjct: 281 VRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSA----TRRSNKKLPFNRSSSDMD 336 Query: 174 TAGSLRELATSRTAPAAK-----NPCLLPY---GKALYSYEGKEPGDLKFNKGDIIVLRR 225 LAT + ++ +P L P G LYS K+ +GD++V+ + Sbjct: 337 LQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYS---------KYMRGDVLVMLK 387 Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPL-------PHAP-----------PQGKALYDF 267 + + + + G + S ++ I PL P+ P P L+DF Sbjct: 388 QTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDF 447 Query: 268 EMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMD 327 + D L T EI+ +L ++D +W G ++IGIFP YV K +I+ Sbjct: 448 PAEQVDD----LNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYV------KVIID-- 495 Query: 328 KPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSV 387 +P S + S V+ F+ + K + Sbjct: 496 -------------IPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILK 542 Query: 388 THRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDV-SSSAGSTPTAV 446 + + + A R G + L+ P +D +S A T V Sbjct: 543 EYVNEEWARGE-----------------VRGRTG-IFPLNFVEPVEDYPTSGANVLSTKV 584 Query: 447 PRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGAS 506 P LP AL+++ + SD+L +G+ ++LE+ W +G Sbjct: 585 PLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGR- 643 Query: 507 LRTGVSGVFPGNYVTP 522 G+FP +V P Sbjct: 644 -LQDREGIFPAVFVRP 658 Score = 53.9 bits (128), Expect = 6e-07 Identities = 28/69 (40%), Positives = 36/69 (52%), Gaps = 3/69 (4%) Query: 187 APAAKNPCLLPYG---KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFL 243 A A ++P G KALY + G+ +L F GDII VD+ W GEL G G Sbjct: 661 AEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIF 720 Query: 244 PASYIQCIQ 252 P +YIQ +Q Sbjct: 721 PKNYIQFLQ 729 Score = 45.4 bits (106), Expect = 2e-04 Identities = 22/63 (34%), Positives = 37/63 (58%), Gaps = 2/63 (3%) Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529 + L+ + ++ D+L L GE+ +LEK W++G + R + G+FP NYV + +P G Sbjct: 442 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG-NCRNQI-GIFPANYVKVIIDIPEG 499 Query: 530 GAG 532 G G Sbjct: 500 GNG 502 Score = 40.4 bits (93), Expect = 0.007 Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 2/62 (3%) Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529 +A + Y ++ DEL +GE+ + E + W +G G +G+FP N+V PV P Sbjct: 518 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFVEPVEDYPTS 575 Query: 530 GA 531 GA Sbjct: 576 GA 577 Score = 38.9 bits (89), Expect = 0.021 Identities = 23/90 (25%), Positives = 43/90 (47%), Gaps = 7/90 (7%) Query: 791 LHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIV 850 L + G F P SM AI P+ + + + + + ++E E+ K GDI+ Sbjct: 644 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGR-----KAKALYDFRGENEDELSFKAGDII 698 Query: 851 FVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 + +D W G L G++G+FP ++++ Sbjct: 699 TELESVDDDWMSGELM--GKSGIFPKNYIQ 726 Score = 37.0 bits (84), Expect = 0.081 Identities = 25/102 (24%), Positives = 41/102 (40%), Gaps = 18/102 (17%) Query: 794 KAGSLDLNFTSPSRQAPLSMAAI----------------RPEPKLLPRERYRVVVSYPPQ 837 + G LNF P P S A + + LP E + S+ + Sbjct: 557 RTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAE 616 Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFV 879 + ++ K GD + + ++ + W +G LQ R G+FP FV Sbjct: 617 TSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFV 656 Score = 35.4 bits (80), Expect = 0.23 Identities = 16/47 (34%), Positives = 29/47 (61%), Gaps = 2/47 (4%) Query: 834 YPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 Y + + E+ EG+I+ + + + W +G ++ GRTG+FP +FVE Sbjct: 523 YIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVE 567 Score = 35.0 bits (79), Expect = 0.31 Identities = 14/51 (27%), Positives = 31/51 (60%), Gaps = 2/51 (3%) Query: 830 VVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 V+ +P + ++ L G+IV++ +K + WY+G + + G+FP ++V+ Sbjct: 443 VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQIGIFPANYVK 491 >gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] Length = 767 Score = 88.2 bits (217), Expect = 3e-17 Identities = 83/341 (24%), Positives = 132/341 (38%), Gaps = 71/341 (20%) Query: 197 PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLP- 255 P+ L+ + ++ DL G+I+ L K+D WY G G PA+Y++ I +P Sbjct: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 534 Query: 256 -----------HAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGD 304 H + + FE + KD L+F++ EI+ + V+E WA G + Sbjct: 535 GGNGKRECVSSHCVKGSRCVARFEY--IGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 592 Query: 305 KIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLP-----SDSGAVASVAPSPTLSS 359 + GIFPL +VE + D P + A+ + +P DSG+ + V P Sbjct: 593 RTGIFPLNFVEPVE--------DYP-TSGANVLSTKVPLKTKKEDSGSNSQVNSLPA--- 640 Query: 360 SGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAAR 419 + + HSFTA +S S + I +L R Sbjct: 641 --------------EWCEALHSFTA-----ETSDDLSFKRGDRIQ--ILERLDSDWCRGR 679 Query: 420 IGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQK 479 + D + A + + A S VP+ ALY ++ + Sbjct: 680 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAK-----------------ALYDFRGEN 722 Query: 480 SDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520 DEL G++ LE D W G + G SG+FP NY+ Sbjct: 723 EDELSFKAGDIITELESVDDDWMSGELM--GKSGIFPKNYI 761 Score = 73.2 bits (178), Expect = 1e-12 Identities = 43/126 (34%), Positives = 67/126 (53%), Gaps = 17/126 (13%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAP- 258 +AL+S+ + DL F +GD I + ++D W G L +G PA + ++P P Sbjct: 644 EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVF---VRPCPAEAK 700 Query: 259 ------PQG---KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIF 309 P+G KALYDF +++D+ L+F +I+T L VD++W G L K GIF Sbjct: 701 SMLAIVPKGRKAKALYDFRGENEDE----LSFKAGDIITELESVDDDWMSGELMGKSGIF 756 Query: 310 PLLYVE 315 P Y++ Sbjct: 757 PKNYIQ 762 Score = 57.0 bits (136), Expect = 8e-08 Identities = 92/436 (21%), Positives = 154/436 (35%), Gaps = 86/436 (19%) Query: 115 VRLLDGIRQRPRAG-TSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGS 173 VR+ + RP G T P PP + P + P L+ S P S++ Sbjct: 317 VRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSA----TRRSNKKLPFNRSSSDMD 372 Query: 174 TAGSLRELATSRTAPAAK-----NPCLLPY---GKALYSYEGKEPGDLKFNKGDIIVLRR 225 LAT + ++ +P L P G LYS K+ +GD++V+ + Sbjct: 373 LQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYS---------KYMRGDVLVMLK 423 Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPL-------PHAP-----------PQGKALYDF 267 + + + + G + S ++ I PL P+ P P L+DF Sbjct: 424 QTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDF 483 Query: 268 EMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMD 327 + D L T EI+ +L ++D +W G ++IGIFP YV K +I+ Sbjct: 484 PAEQVDD----LNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYV------KVIID-- 531 Query: 328 KPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSV 387 +P S + S V+ F+ + K + Sbjct: 532 -------------IPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILK 578 Query: 388 THRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDV-SSSAGSTPTAV 446 + + + A R G + L+ P +D +S A T V Sbjct: 579 EYVNEEWARGE-----------------VRGRTG-IFPLNFVEPVEDYPTSGANVLSTKV 620 Query: 447 PRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGAS 506 P LP AL+++ + SD+L +G+ ++LE+ W +G Sbjct: 621 PLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGR- 679 Query: 507 LRTGVSGVFPGNYVTP 522 G+FP +V P Sbjct: 680 -LQDREGIFPAVFVRP 694 Score = 53.9 bits (128), Expect = 6e-07 Identities = 28/69 (40%), Positives = 36/69 (52%), Gaps = 3/69 (4%) Query: 187 APAAKNPCLLPYG---KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFL 243 A A ++P G KALY + G+ +L F GDII VD+ W GEL G G Sbjct: 697 AEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIF 756 Query: 244 PASYIQCIQ 252 P +YIQ +Q Sbjct: 757 PKNYIQFLQ 765 Score = 45.4 bits (106), Expect = 2e-04 Identities = 22/63 (34%), Positives = 37/63 (58%), Gaps = 2/63 (3%) Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529 + L+ + ++ D+L L GE+ +LEK W++G + R + G+FP NYV + +P G Sbjct: 478 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG-NCRNQI-GIFPANYVKVIIDIPEG 535 Query: 530 GAG 532 G G Sbjct: 536 GNG 538 Score = 40.4 bits (93), Expect = 0.007 Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 2/62 (3%) Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529 +A + Y ++ DEL +GE+ + E + W +G G +G+FP N+V PV P Sbjct: 554 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFVEPVEDYPTS 611 Query: 530 GA 531 GA Sbjct: 612 GA 613 Score = 38.9 bits (89), Expect = 0.021 Identities = 23/90 (25%), Positives = 43/90 (47%), Gaps = 7/90 (7%) Query: 791 LHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIV 850 L + G F P SM AI P+ + + + + + ++E E+ K GDI+ Sbjct: 680 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGR-----KAKALYDFRGENEDELSFKAGDII 734 Query: 851 FVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 + +D W G L G++G+FP ++++ Sbjct: 735 TELESVDDDWMSGELM--GKSGIFPKNYIQ 762 Score = 37.0 bits (84), Expect = 0.081 Identities = 25/102 (24%), Positives = 41/102 (40%), Gaps = 18/102 (17%) Query: 794 KAGSLDLNFTSPSRQAPLSMAAI----------------RPEPKLLPRERYRVVVSYPPQ 837 + G LNF P P S A + + LP E + S+ + Sbjct: 593 RTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAE 652 Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFV 879 + ++ K GD + + ++ + W +G LQ R G+FP FV Sbjct: 653 TSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFV 692 Score = 35.4 bits (80), Expect = 0.23 Identities = 16/47 (34%), Positives = 29/47 (61%), Gaps = 2/47 (4%) Query: 834 YPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 Y + + E+ EG+I+ + + + W +G ++ GRTG+FP +FVE Sbjct: 559 YIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVE 603 Score = 35.0 bits (79), Expect = 0.31 Identities = 14/51 (27%), Positives = 31/51 (60%), Gaps = 2/51 (3%) Query: 830 VVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 V+ +P + ++ L G+IV++ +K + WY+G + + G+FP ++V+ Sbjct: 479 VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQIGIFPANYVK 527 >gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] Length = 790 Score = 88.2 bits (217), Expect = 3e-17 Identities = 83/341 (24%), Positives = 132/341 (38%), Gaps = 71/341 (20%) Query: 197 PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLP- 255 P+ L+ + ++ DL G+I+ L K+D WY G G PA+Y++ I +P Sbjct: 498 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 557 Query: 256 -----------HAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGD 304 H + + FE + KD L+F++ EI+ + V+E WA G + Sbjct: 558 GGNGKRECVSSHCVKGSRCVARFEY--IGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 615 Query: 305 KIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLP-----SDSGAVASVAPSPTLSS 359 + GIFPL +VE + D P + A+ + +P DSG+ + V P Sbjct: 616 RTGIFPLNFVEPVE--------DYP-TSGANVLSTKVPLKTKKEDSGSNSQVNSLPA--- 663 Query: 360 SGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAAR 419 + + HSFTA +S S + I +L R Sbjct: 664 --------------EWCEALHSFTA-----ETSDDLSFKRGDRIQ--ILERLDSDWCRGR 702 Query: 420 IGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQK 479 + D + A + + A S VP+ ALY ++ + Sbjct: 703 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAK-----------------ALYDFRGEN 745 Query: 480 SDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520 DEL G++ LE D W G + G SG+FP NY+ Sbjct: 746 EDELSFKAGDIITELESVDDDWMSGELM--GKSGIFPKNYI 784 Score = 73.2 bits (178), Expect = 1e-12 Identities = 43/126 (34%), Positives = 67/126 (53%), Gaps = 17/126 (13%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAP- 258 +AL+S+ + DL F +GD I + ++D W G L +G PA + ++P P Sbjct: 667 EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVF---VRPCPAEAK 723 Query: 259 ------PQG---KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIF 309 P+G KALYDF +++D+ L+F +I+T L VD++W G L K GIF Sbjct: 724 SMLAIVPKGRKAKALYDFRGENEDE----LSFKAGDIITELESVDDDWMSGELMGKSGIF 779 Query: 310 PLLYVE 315 P Y++ Sbjct: 780 PKNYIQ 785 Score = 63.5 bits (153), Expect = 8e-10 Identities = 72/346 (20%), Positives = 126/346 (36%), Gaps = 64/346 (18%) Query: 196 LPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPL- 254 +P+G A + PG+L +GD++V+ ++ + + + G + S ++ I PL Sbjct: 417 VPHGIANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLD 476 Query: 255 ------PHAP-----------PQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENW 297 P+ P P L+DF + D L T EI+ +L ++D +W Sbjct: 477 EHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDD----LNLTSGEIVYLLEKIDTDW 532 Query: 298 AEGMLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTL 357 G ++IGIFP YV K +I+ +P S + Sbjct: 533 YRGNCRNQIGIFPANYV------KVIID---------------IPEGGNGKRECVSSHCV 571 Query: 358 SSSGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAA 417 S V+ F+ + K + + + + A Sbjct: 572 KGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGE-----------------VR 614 Query: 418 ARIGDLAHLSCAAPTQDV-SSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYK 476 R G + L+ P +D +S A T VP LP AL+++ Sbjct: 615 GRTG-IFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFT 673 Query: 477 PQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTP 522 + SD+L +G+ ++LE+ W +G G+FP +V P Sbjct: 674 AETSDDLSFKRGDRIQILERLDSDWCRGR--LQDREGIFPAVFVRP 717 Score = 53.9 bits (128), Expect = 6e-07 Identities = 28/69 (40%), Positives = 36/69 (52%), Gaps = 3/69 (4%) Query: 187 APAAKNPCLLPYG---KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFL 243 A A ++P G KALY + G+ +L F GDII VD+ W GEL G G Sbjct: 720 AEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIF 779 Query: 244 PASYIQCIQ 252 P +YIQ +Q Sbjct: 780 PKNYIQFLQ 788 Score = 45.4 bits (106), Expect = 2e-04 Identities = 22/63 (34%), Positives = 37/63 (58%), Gaps = 2/63 (3%) Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529 + L+ + ++ D+L L GE+ +LEK W++G + R + G+FP NYV + +P G Sbjct: 501 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG-NCRNQI-GIFPANYVKVIIDIPEG 558 Query: 530 GAG 532 G G Sbjct: 559 GNG 561 Score = 40.4 bits (93), Expect = 0.007 Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 2/62 (3%) Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529 +A + Y ++ DEL +GE+ + E + W +G G +G+FP N+V PV P Sbjct: 577 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFVEPVEDYPTS 634 Query: 530 GA 531 GA Sbjct: 635 GA 636 Score = 38.9 bits (89), Expect = 0.021 Identities = 23/90 (25%), Positives = 43/90 (47%), Gaps = 7/90 (7%) Query: 791 LHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIV 850 L + G F P SM AI P+ + + + + + ++E E+ K GDI+ Sbjct: 703 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGR-----KAKALYDFRGENEDELSFKAGDII 757 Query: 851 FVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 + +D W G L G++G+FP ++++ Sbjct: 758 TELESVDDDWMSGELM--GKSGIFPKNYIQ 785 Score = 37.0 bits (84), Expect = 0.081 Identities = 25/102 (24%), Positives = 41/102 (40%), Gaps = 18/102 (17%) Query: 794 KAGSLDLNFTSPSRQAPLSMAAI----------------RPEPKLLPRERYRVVVSYPPQ 837 + G LNF P P S A + + LP E + S+ + Sbjct: 616 RTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAE 675 Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFV 879 + ++ K GD + + ++ + W +G LQ R G+FP FV Sbjct: 676 TSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFV 715 Score = 35.4 bits (80), Expect = 0.23 Identities = 16/47 (34%), Positives = 29/47 (61%), Gaps = 2/47 (4%) Query: 834 YPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 Y + + E+ EG+I+ + + + W +G ++ GRTG+FP +FVE Sbjct: 582 YIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVE 626 Score = 35.0 bits (79), Expect = 0.31 Identities = 14/51 (27%), Positives = 31/51 (60%), Gaps = 2/51 (3%) Query: 830 VVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 V+ +P + ++ L G+IV++ +K + WY+G + + G+FP ++V+ Sbjct: 502 VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQIGIFPANYVK 550 >gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo sapiens] Length = 1292 Score = 87.8 bits (216), Expect = 4e-17 Identities = 52/172 (30%), Positives = 89/172 (51%), Gaps = 17/172 (9%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259 +A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P Sbjct: 799 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 858 Query: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307 + G+A+ F Q + ++F K E +T+LR+VDENW EG + + G Sbjct: 859 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 916 Query: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAASSCNASLPSDSGAVASVAPSPT 356 IFP+ YV++ K ++ MD P ++ S + P S + P+P+ Sbjct: 917 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLITPAPS 968 Score = 82.4 bits (202), Expect = 2e-15 Identities = 111/486 (22%), Positives = 184/486 (37%), Gaps = 98/486 (20%) Query: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505 +P A ++ TP +V L +A + + E+ KGE +L + + W++G Sbjct: 850 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 908 Query: 506 SLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMH-PGSGSLSSLAT 564 T G+FP YV + R PL K M P S S S AT Sbjct: 909 IPGTSRQGIFPITYVDVIKR-----------------PLVKNPVDYMDLPFSSSPSRSAT 951 Query: 565 ATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTAT 624 A+ PQ + H P S L HS + + + + S R + Sbjct: 952 AS--------PQ-FSSHSKLITPAPSSLPHSRRALSPEMHAVTSEWISLTVGVPGRRSLA 1002 Query: 625 VSPLRTQNSPSRLPATSL--RPHSVVSPQHSHQ-----PPVQMCPRP---------AIPL 668 ++P LP S+ H +SP+ S P + RP A+P Sbjct: 1003 LTPPLPP-----LPEASIYNTDHLALSPRASPSLSLSLPHLSWSDRPTPRSVASPLALPS 1057 Query: 669 TSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLA 728 ++ P + ++ ++NG+ G +P++ G D ++ L+ Sbjct: 1058 PHKTYSLAPTSQASLHMNGDGG--------VHTPSS-GIHQDSFLQLPLGSSDSVISQLS 1108 Query: 729 GASTKKKSRSP-PSVSPTHDPQVAVDALLQGAVGPEVSSLSI------------------ 769 A + + R P S ++ + A +G GP++S S Sbjct: 1109 DAFSSQSKRQPWREESGQYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSD 1168 Query: 770 -----HGRAGSCPIESEMQGA--------MGMEPLHRKAGSLDLNFTSPSRQAPLSMAAI 816 R G P+ S G+ G E RKA S+Q + Sbjct: 1169 LNTPEESRPGK-PLGSAFPGSEAEQTERHRGGEQAGRKAAR-----RGGSQQPQAQQRRV 1222 Query: 817 RPEPKLLPRE--RYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLF 874 P+ ++ Y+ + SY PQ++ E+EL++GDIV V +K +DGW+ GT +R + G F Sbjct: 1223 TPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTF 1282 Query: 875 PGSFVE 880 PG++V+ Sbjct: 1283 PGNYVK 1288 Score = 73.9 bits (180), Expect = 6e-13 Identities = 36/68 (52%), Positives = 44/68 (64%), Gaps = 2/68 (2%) Query: 458 TPPKVQLPLNV--YLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVF 515 TP + Q ++ Y ALY+Y PQ DELEL G++ V+EKC DGWF G S RT G F Sbjct: 1223 TPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTF 1282 Query: 516 PGNYVTPV 523 PGNYV P+ Sbjct: 1283 PGNYVKPL 1290 Score = 45.8 bits (107), Expect = 2e-04 Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%) Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E Sbjct: 799 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 848 Score = 40.8 bits (94), Expect = 0.006 Identities = 36/129 (27%), Positives = 54/129 (41%), Gaps = 20/129 (15%) Query: 130 SPGGSPPARPI----PGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELATSR 185 +P S P +P+ PG A T GG AG A GS + A R Sbjct: 1171 TPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGRK----------AARRGGSQQPQAQQR 1220 Query: 186 TAPAAKNPC---LLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ-- 240 ++ L Y +ALYSY + +L+ GDI+ + K D+ W+ G T+ Sbjct: 1221 RVTPDRSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQF 1279 Query: 241 GFLPASYIQ 249 G P +Y++ Sbjct: 1280 GTFPGNYVK 1288 >gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo sapiens] Length = 740 Score = 83.6 bits (205), Expect = 8e-16 Identities = 55/181 (30%), Positives = 90/181 (49%), Gaps = 18/181 (9%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259 +A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P Sbjct: 505 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 564 Query: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307 + G+A+ F Q + ++F K E +T+LR+VDENW EG + + G Sbjct: 565 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 622 Query: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAAS-SCNASLPSDSGAVASVAPSPTLSSSGAV 363 IFP+ YV++ K ++ MD P ++ S S AS V P + +S Sbjct: 623 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLF 682 Query: 364 S 364 S Sbjct: 683 S 683 Score = 81.3 bits (199), Expect = 4e-15 Identities = 42/90 (46%), Positives = 53/90 (58%), Gaps = 2/90 (2%) Query: 436 SSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNV--YLALYAYKPQKSDELELHKGEMYRV 493 SSS + TA P+ + TP + Q ++ Y ALY+Y PQ DELEL G++ V Sbjct: 649 SSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 708 Query: 494 LEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523 +EKC DGWF G S RT G FPGNYV P+ Sbjct: 709 MEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738 Score = 63.2 bits (152), Expect = 1e-09 Identities = 35/93 (37%), Positives = 57/93 (61%), Gaps = 10/93 (10%) Query: 798 LDLNFTS-PSRQAPLSMAAIRPEPKLLPRER---------YRVVVSYPPQSEAEIELKEG 847 +DL F+S PSR A S + + + + +R Y+ + SY PQ++ E+EL++G Sbjct: 644 MDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 703 Query: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 DIV V +K +DGW+ GT +R + G FPG++V+ Sbjct: 704 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736 Score = 45.8 bits (107), Expect = 2e-04 Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%) Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E Sbjct: 505 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 554 Score = 37.0 bits (84), Expect = 0.081 Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 1/80 (1%) Query: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505 +P A ++ TP +V L +A + + E+ KGE +L + + W++G Sbjct: 556 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 614 Query: 506 SLRTGVSGVFPGNYVTPVSR 525 T G+FP YV + R Sbjct: 615 IPGTSRQGIFPITYVDVIKR 634 Score = 35.8 bits (81), Expect = 0.18 Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249 +ALYSY + +L+ GDI+ + K D+ W+ G T+ G P +Y++ Sbjct: 685 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736 Score = 33.1 bits (74), Expect = 1.2 Identities = 10/43 (23%), Positives = 28/43 (65%) Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 ++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+ Sbjct: 588 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 630 Score = 32.7 bits (73), Expect = 1.5 Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 2/50 (4%) Query: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520 A + +K Q EL L KG++ + ++ W++G G G+FP Y+ Sbjct: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 553 >gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo sapiens] Length = 781 Score = 83.6 bits (205), Expect = 8e-16 Identities = 55/181 (30%), Positives = 90/181 (49%), Gaps = 18/181 (9%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259 +A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P Sbjct: 546 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 605 Query: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307 + G+A+ F Q + ++F K E +T+LR+VDENW EG + + G Sbjct: 606 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 663 Query: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAAS-SCNASLPSDSGAVASVAPSPTLSSSGAV 363 IFP+ YV++ K ++ MD P ++ S S AS V P + +S Sbjct: 664 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLF 723 Query: 364 S 364 S Sbjct: 724 S 724 Score = 81.3 bits (199), Expect = 4e-15 Identities = 42/90 (46%), Positives = 53/90 (58%), Gaps = 2/90 (2%) Query: 436 SSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNV--YLALYAYKPQKSDELELHKGEMYRV 493 SSS + TA P+ + TP + Q ++ Y ALY+Y PQ DELEL G++ V Sbjct: 690 SSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 749 Query: 494 LEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523 +EKC DGWF G S RT G FPGNYV P+ Sbjct: 750 MEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779 Score = 63.2 bits (152), Expect = 1e-09 Identities = 35/93 (37%), Positives = 57/93 (61%), Gaps = 10/93 (10%) Query: 798 LDLNFTS-PSRQAPLSMAAIRPEPKLLPRER---------YRVVVSYPPQSEAEIELKEG 847 +DL F+S PSR A S + + + + +R Y+ + SY PQ++ E+EL++G Sbjct: 685 MDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 744 Query: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 DIV V +K +DGW+ GT +R + G FPG++V+ Sbjct: 745 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777 Score = 45.8 bits (107), Expect = 2e-04 Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%) Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E Sbjct: 546 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 595 Score = 37.0 bits (84), Expect = 0.081 Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 1/80 (1%) Query: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505 +P A ++ TP +V L +A + + E+ KGE +L + + W++G Sbjct: 597 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 655 Query: 506 SLRTGVSGVFPGNYVTPVSR 525 T G+FP YV + R Sbjct: 656 IPGTSRQGIFPITYVDVIKR 675 Score = 35.8 bits (81), Expect = 0.18 Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249 +ALYSY + +L+ GDI+ + K D+ W+ G T+ G P +Y++ Sbjct: 726 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777 Score = 33.1 bits (74), Expect = 1.2 Identities = 10/43 (23%), Positives = 28/43 (65%) Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 ++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+ Sbjct: 629 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 671 Score = 32.7 bits (73), Expect = 1.5 Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 2/50 (4%) Query: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520 A + +K Q EL L KG++ + ++ W++G G G+FP Y+ Sbjct: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 594 >gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sapiens] Length = 816 Score = 83.6 bits (205), Expect = 8e-16 Identities = 55/181 (30%), Positives = 90/181 (49%), Gaps = 18/181 (9%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259 +A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P Sbjct: 581 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 640 Query: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307 + G+A+ F Q + ++F K E +T+LR+VDENW EG + + G Sbjct: 641 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 698 Query: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAAS-SCNASLPSDSGAVASVAPSPTLSSSGAV 363 IFP+ YV++ K ++ MD P ++ S S AS V P + +S Sbjct: 699 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLF 758 Query: 364 S 364 S Sbjct: 759 S 759 Score = 81.3 bits (199), Expect = 4e-15 Identities = 42/90 (46%), Positives = 53/90 (58%), Gaps = 2/90 (2%) Query: 436 SSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNV--YLALYAYKPQKSDELELHKGEMYRV 493 SSS + TA P+ + TP + Q ++ Y ALY+Y PQ DELEL G++ V Sbjct: 725 SSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 784 Query: 494 LEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523 +EKC DGWF G S RT G FPGNYV P+ Sbjct: 785 MEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814 Score = 63.2 bits (152), Expect = 1e-09 Identities = 35/93 (37%), Positives = 57/93 (61%), Gaps = 10/93 (10%) Query: 798 LDLNFTS-PSRQAPLSMAAIRPEPKLLPRER---------YRVVVSYPPQSEAEIELKEG 847 +DL F+S PSR A S + + + + +R Y+ + SY PQ++ E+EL++G Sbjct: 720 MDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 779 Query: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 DIV V +K +DGW+ GT +R + G FPG++V+ Sbjct: 780 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 812 Score = 45.8 bits (107), Expect = 2e-04 Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%) Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E Sbjct: 581 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 630 Score = 37.0 bits (84), Expect = 0.081 Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 1/80 (1%) Query: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505 +P A ++ TP +V L +A + + E+ KGE +L + + W++G Sbjct: 632 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 690 Query: 506 SLRTGVSGVFPGNYVTPVSR 525 T G+FP YV + R Sbjct: 691 IPGTSRQGIFPITYVDVIKR 710 Score = 35.8 bits (81), Expect = 0.18 Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249 +ALYSY + +L+ GDI+ + K D+ W+ G T+ G P +Y++ Sbjct: 761 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 812 Score = 33.1 bits (74), Expect = 1.2 Identities = 10/43 (23%), Positives = 28/43 (65%) Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 ++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+ Sbjct: 664 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 706 Score = 32.7 bits (73), Expect = 1.5 Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 2/50 (4%) Query: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520 A + +K Q EL L KG++ + ++ W++G G G+FP Y+ Sbjct: 582 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 629 >gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo sapiens] Length = 684 Score = 83.6 bits (205), Expect = 8e-16 Identities = 55/181 (30%), Positives = 90/181 (49%), Gaps = 18/181 (9%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259 +A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P Sbjct: 449 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 508 Query: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307 + G+A+ F Q + ++F K E +T+LR+VDENW EG + + G Sbjct: 509 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 566 Query: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAAS-SCNASLPSDSGAVASVAPSPTLSSSGAV 363 IFP+ YV++ K ++ MD P ++ S S AS V P + +S Sbjct: 567 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLF 626 Query: 364 S 364 S Sbjct: 627 S 627 Score = 81.3 bits (199), Expect = 4e-15 Identities = 42/90 (46%), Positives = 53/90 (58%), Gaps = 2/90 (2%) Query: 436 SSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNV--YLALYAYKPQKSDELELHKGEMYRV 493 SSS + TA P+ + TP + Q ++ Y ALY+Y PQ DELEL G++ V Sbjct: 593 SSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 652 Query: 494 LEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523 +EKC DGWF G S RT G FPGNYV P+ Sbjct: 653 MEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682 Score = 63.2 bits (152), Expect = 1e-09 Identities = 35/93 (37%), Positives = 57/93 (61%), Gaps = 10/93 (10%) Query: 798 LDLNFTS-PSRQAPLSMAAIRPEPKLLPRER---------YRVVVSYPPQSEAEIELKEG 847 +DL F+S PSR A S + + + + +R Y+ + SY PQ++ E+EL++G Sbjct: 588 MDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 647 Query: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 DIV V +K +DGW+ GT +R + G FPG++V+ Sbjct: 648 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 680 Score = 45.8 bits (107), Expect = 2e-04 Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%) Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E Sbjct: 449 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 498 Score = 37.0 bits (84), Expect = 0.081 Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 1/80 (1%) Query: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505 +P A ++ TP +V L +A + + E+ KGE +L + + W++G Sbjct: 500 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 558 Query: 506 SLRTGVSGVFPGNYVTPVSR 525 T G+FP YV + R Sbjct: 559 IPGTSRQGIFPITYVDVIKR 578 Score = 35.8 bits (81), Expect = 0.18 Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%) Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249 +ALYSY + +L+ GDI+ + K D+ W+ G T+ G P +Y++ Sbjct: 629 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 680 Score = 33.1 bits (74), Expect = 1.2 Identities = 10/43 (23%), Positives = 28/43 (65%) Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 ++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+ Sbjct: 532 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 574 Score = 32.7 bits (73), Expect = 1.5 Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 2/50 (4%) Query: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520 A + +K Q EL L KG++ + ++ W++G G G+FP Y+ Sbjct: 450 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 497 >gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens] Length = 368 Score = 76.3 bits (186), Expect = 1e-13 Identities = 46/142 (32%), Positives = 70/142 (49%), Gaps = 5/142 (3%) Query: 115 VRLLDGIRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGST 174 V++LD + ++ + S P R + P G + G P + AA+ S Sbjct: 230 VQILDELAEKLKRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSF 289 Query: 175 AGSLRELAT-SRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYH 233 S + + T SR+ P P KALY +E + G+L F++GD+I L ++DE WY Sbjct: 290 RSSDKPIRTPSRSMPPLDQPSC----KALYDFEPENDGELGFHEGDVITLTNQIDENWYE 345 Query: 234 GELHGTQGFLPASYIQCIQPLP 255 G L G GF P SY++ + PLP Sbjct: 346 GMLDGQSGFFPLSYVEVLVPLP 367 Score = 54.7 bits (130), Expect = 4e-07 Identities = 27/62 (43%), Positives = 39/62 (62%), Gaps = 4/62 (6%) Query: 255 PHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYV 314 P P KALYDFE ++ + L F + +++T+ ++DENW EGML + G FPL YV Sbjct: 305 PLDQPSCKALYDFEPENDGE----LGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360 Query: 315 EL 316 E+ Sbjct: 361 EV 362 Score = 43.1 bits (100), Expect = 0.001 Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 10/99 (10%) Query: 437 SSAGSTPTAVPRAASVSGEQG------TPPKVQLPLNV--YLALYAYKPQKSDELELHKG 488 S+ G T P+ A+ S + TP + PL+ ALY ++P+ EL H+G Sbjct: 271 SNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEG 330 Query: 489 EMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVP 527 ++ + + + W++G + G SG FP +YV + +P Sbjct: 331 DVITLTNQIDENWYEG--MLDGQSGFFPLSYVEVLVPLP 367 Score = 42.4 bits (98), Expect = 0.002 Identities = 23/84 (27%), Positives = 43/84 (51%), Gaps = 13/84 (15%) Query: 797 SLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR 856 S D +PSR P L + + + + P+++ E+ EGD++ + + Sbjct: 291 SSDKPIRTPSRSMPP-----------LDQPSCKALYDFEPENDGELGFHEGDVITLTNQI 339 Query: 857 EDGWYKGTLQRNGRTGLFPGSFVE 880 ++ WY+G L +G++G FP S+VE Sbjct: 340 DENWYEGML--DGQSGFFPLSYVE 361 >gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] Length = 1220 Score = 72.0 bits (175), Expect = 2e-12 Identities = 55/186 (29%), Positives = 86/186 (46%), Gaps = 35/186 (18%) Query: 151 GGGGGAAGSTPGSPVFLSAAAGS-TAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKE 209 G G AG P + V L + GS TAG +T K P + + + SY Sbjct: 1041 GTVGDKAGVFPSNYVRLKDSEGSGTAG--------KTGSLGKKPEI---AQVIASYTATG 1089 Query: 210 PGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ-----GFLPASYIQCIQP-----LPHAPP 259 P L G +I++R+K W+ GEL G+ PA+Y++ + P P PP Sbjct: 1090 PEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPP 1149 Query: 260 QGKAL---------YDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFP 310 + AL YD+ ++ D+ L F K +I+ VL + D +W +G + ++G+FP Sbjct: 1150 KSTALAAVCQVIGMYDYTAQNDDE----LAFNKGQIINVLNKEDPDWWKGEVNGQVGLFP 1205 Query: 311 LLYVEL 316 YV+L Sbjct: 1206 SNYVKL 1211 Score = 68.9 bits (167), Expect = 2e-11 Identities = 54/184 (29%), Positives = 86/184 (46%), Gaps = 44/184 (23%) Query: 174 TAGSLRELA--TSRTAPAAKNPCLLPYGK--------ALYSYEGKEPGDLKFNKGDIIVL 223 +AG LR+ + T TA + +L G+ ALY + K+ L FNK D+I + Sbjct: 883 SAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITV 942 Query: 224 RRKVDEQWYHGELHGTQGFLPASYIQCIQ-PL----------------------PHAPP- 259 + D W+ GE+ G +G+ P SY++ I P+ P A P Sbjct: 943 LEQQD-MWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPV 1001 Query: 260 ----QGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVE 315 + A+Y +E ++ LTF + +++ V ++ D +W G +GDK G+FP YV Sbjct: 1002 VSGEEFIAMYTYESSEQGD----LTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVR 1056 Query: 316 LNDS 319 L DS Sbjct: 1057 LKDS 1060 Score = 54.7 bits (130), Expect = 4e-07 Identities = 44/184 (23%), Positives = 78/184 (42%), Gaps = 25/184 (13%) Query: 167 LSAAAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRK 226 + + + + SL+ +A+ P + A+Y+YE E GDL F +GD+I++ +K Sbjct: 979 MDSGSSESPASLKRVASPAAKPVVSGEEFI----AMYTYESSEQGDLTFQQGDVILVTKK 1034 Query: 227 VDEQWYHGELHGTQGFLPASYIQC-----------IQPLPHAPPQGKALYDFEMKDKDQD 275 D W+ G + G P++Y++ L P + + + +Q Sbjct: 1035 -DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQ- 1092 Query: 276 KDCLTFTKDEILTVLRRVDENWAEGML---GDK--IGIFPLLYVELNDSAKQLIEMDKPC 330 LT +++ + ++ W EG L G K IG FP YV+L I +P Sbjct: 1093 ---LTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPP 1149 Query: 331 PAAA 334 + A Sbjct: 1150 KSTA 1153 Score = 50.8 bits (120), Expect = 5e-06 Identities = 83/365 (22%), Positives = 130/365 (35%), Gaps = 71/365 (19%) Query: 198 YGKALYSYEGKEPGDLKFNKGDIIVLRRK-VDEQ------WYHGELHGTQGFLPASYIQC 250 Y +ALY +E + ++ GDI++++ + VDE W GEL G G+ PA+Y + Sbjct: 744 YYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEK 803 Query: 251 IQ----PLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKI 306 I P P P + L T E T NWA D Sbjct: 804 IPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPST----TPNNWA-----DFS 854 Query: 307 GIFPLLYVELNDSAKQLIEMDKP---CPAAASSCNASLPSDSGAVASVAPSPTLSSSGAV 363 +P E ++ +P P+A S + + A S +PSP L V Sbjct: 855 STWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGS-SPSPVLGQGEKV 913 Query: 364 SAFQRRV--------DGKKNTKKRHSFTALSVTHR--SSQAASHRHSMEISAPVLISSSD 413 Q + D N K T L + + S LIS Sbjct: 914 EGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPI 973 Query: 414 PRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAAS------VSGEQGTPPKVQLPLN 467 ++ + + S + +P ++ R AS VSGE+ Sbjct: 974 RKSTS----------------MDSGSSESPASLKRVASPAAKPVVSGEE----------- 1006 Query: 468 VYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVP 527 ++A+Y Y+ + +L +G++ V +K D W + +GVFP NYV Sbjct: 1007 -FIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDK---AGVFPSNYVRLKDSEG 1062 Query: 528 AGGAG 532 +G AG Sbjct: 1063 SGTAG 1067 Score = 47.8 bits (112), Expect = 5e-05 Identities = 77/318 (24%), Positives = 119/318 (37%), Gaps = 67/318 (21%) Query: 262 KALYDFEMKDKDQ---DKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELND 318 +ALY FE + D+ + K E + + + W G L K G FP Y E Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE--- 802 Query: 319 SAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKK 378 ++ E + P P + + S P+ A+ P+P +S S Sbjct: 803 ---KIPENEVPAPVKPVTDSTSAPAPKLALRET-PAPLAVTSSEPST---------TPNN 849 Query: 379 RHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSS 438 F++ T + + + + P L S G L S P +++ Sbjct: 850 WADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPS-------AGQLRQRSAFTP----ATA 898 Query: 439 AGSTPTAV-PRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKC 497 GS+P+ V + V G Q ALY ++ +K + L +K ++ VLE+ Sbjct: 899 TGSSPSPVLGQGEKVEGLQAQ------------ALYPWRAKKDNHLNFNKNDVITVLEQ- 945 Query: 498 QDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSG 557 QD W+ G G G FP +YV +S GP R +T+M SG Sbjct: 946 QDMWWFGEV--QGQKGWFPKSYVKLIS-------GPIRK------------STSM--DSG 982 Query: 558 SLSSLATATRPALPITTP 575 S S A+ R A P P Sbjct: 983 SSESPASLKRVASPAAKP 1000 Score = 47.4 bits (111), Expect = 6e-05 Identities = 98/439 (22%), Positives = 158/439 (35%), Gaps = 76/439 (17%) Query: 469 YLALYAYKPQKSDELELHKGEMYRVLEKCQD-------GWFKGASLRTGVSGVFPGNYVT 521 Y ALY ++ + DE+ + G++ V + D GW G L+ G +G FP NY Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWL-GGELK-GKTGWFPANYAE 802 Query: 522 PVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQH 581 + P N V +P+ +T P LA PA P A Sbjct: 803 KI----------PENEVP--APVKPVTDSTSAPAP----KLALRETPA-----PLAVTSS 841 Query: 582 PTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATV---SPLRTQNSPSRLP 638 ++ P S PT++ + AAQ P+ TV LR +++ + Sbjct: 842 EPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQ----PSLTVPSAGQLRQRSAFTPAT 897 Query: 639 ATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLS 698 AT P V+ Q +Q A A+ P N I VL Sbjct: 898 ATGSSPSPVLG-QGEKVEGLQ------------AQALYPWRAKKDNHLNFNKNDVITVLE 944 Query: 699 TSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSR-SPPSVSPTHDPQVAVDALLQ 757 G E + +K +KL++G K S S S SP +VA A Sbjct: 945 QQDMWWFG----EVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKP 1000 Query: 758 GAVGPEVSSLSIHGRA---------GSCPIESEMQGAMGMEPLHRKAGSLDLNFT----S 804 G E ++ + + G + ++ G + KAG N+ S Sbjct: 1001 VVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDS 1060 Query: 805 PSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGT 864 ++ +P++ +V+ SY ++ L G ++ + KK GW++G Sbjct: 1061 EGSGTAGKTGSLGKKPEIA-----QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGE 1115 Query: 865 LQRNGR---TGLFPGSFVE 880 LQ G+ G FP ++V+ Sbjct: 1116 LQARGKKRQIGWFPANYVK 1134 Score = 43.1 bits (100), Expect = 0.001 Identities = 21/51 (41%), Positives = 28/51 (54%), Gaps = 2/51 (3%) Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520 + +Y Y Q DEL +KG++ VL K W+KG G G+FP NYV Sbjct: 1161 IGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV--NGQVGLFPSNYV 1209 Score = 39.3 bits (90), Expect = 0.016 Identities = 17/47 (36%), Positives = 29/47 (61%), Gaps = 2/47 (4%) Query: 834 YPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 Y Q++ E+ +G I+ V K + W+KG + NG+ GLFP ++V+ Sbjct: 1166 YTAQNDDELAFNKGQIINVLNKEDPDWWKGEV--NGQVGLFPSNYVK 1210 Score = 36.6 bits (83), Expect = 0.11 Identities = 28/87 (32%), Positives = 41/87 (47%), Gaps = 13/87 (14%) Query: 805 PSRQAPLSMAAIRP----EPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFV-------H 853 P+ QAP S A P + + YR + + +S EI ++ GDIV V Sbjct: 718 PAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDES 777 Query: 854 KKREDGWYKGTLQRNGRTGLFPGSFVE 880 + E GW G L+ G+TG FP ++ E Sbjct: 778 QTGEPGWLGGELK--GKTGWFPANYAE 802 >gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] Length = 1721 Score = 72.0 bits (175), Expect = 2e-12 Identities = 55/186 (29%), Positives = 86/186 (46%), Gaps = 35/186 (18%) Query: 151 GGGGGAAGSTPGSPVFLSAAAGS-TAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKE 209 G G AG P + V L + GS TAG +T K P + + + SY Sbjct: 1041 GTVGDKAGVFPSNYVRLKDSEGSGTAG--------KTGSLGKKPEI---AQVIASYTATG 1089 Query: 210 PGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ-----GFLPASYIQCIQP-----LPHAPP 259 P L G +I++R+K W+ GEL G+ PA+Y++ + P P PP Sbjct: 1090 PEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPP 1149 Query: 260 QGKAL---------YDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFP 310 + AL YD+ ++ D+ L F K +I+ VL + D +W +G + ++G+FP Sbjct: 1150 KSTALAAVCQVIGMYDYTAQNDDE----LAFNKGQIINVLNKEDPDWWKGEVNGQVGLFP 1205 Query: 311 LLYVEL 316 YV+L Sbjct: 1206 SNYVKL 1211 Score = 68.9 bits (167), Expect = 2e-11 Identities = 54/184 (29%), Positives = 86/184 (46%), Gaps = 44/184 (23%) Query: 174 TAGSLRELA--TSRTAPAAKNPCLLPYGK--------ALYSYEGKEPGDLKFNKGDIIVL 223 +AG LR+ + T TA + +L G+ ALY + K+ L FNK D+I + Sbjct: 883 SAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITV 942 Query: 224 RRKVDEQWYHGELHGTQGFLPASYIQCIQ-PL----------------------PHAPP- 259 + D W+ GE+ G +G+ P SY++ I P+ P A P Sbjct: 943 LEQQD-MWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPV 1001 Query: 260 ----QGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVE 315 + A+Y +E ++ LTF + +++ V ++ D +W G +GDK G+FP YV Sbjct: 1002 VSGEEFIAMYTYESSEQGD----LTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVR 1056 Query: 316 LNDS 319 L DS Sbjct: 1057 LKDS 1060 Score = 54.7 bits (130), Expect = 4e-07 Identities = 44/184 (23%), Positives = 78/184 (42%), Gaps = 25/184 (13%) Query: 167 LSAAAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRK 226 + + + + SL+ +A+ P + A+Y+YE E GDL F +GD+I++ +K Sbjct: 979 MDSGSSESPASLKRVASPAAKPVVSGEEFI----AMYTYESSEQGDLTFQQGDVILVTKK 1034 Query: 227 VDEQWYHGELHGTQGFLPASYIQC-----------IQPLPHAPPQGKALYDFEMKDKDQD 275 D W+ G + G P++Y++ L P + + + +Q Sbjct: 1035 -DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQ- 1092 Query: 276 KDCLTFTKDEILTVLRRVDENWAEGML---GDK--IGIFPLLYVELNDSAKQLIEMDKPC 330 LT +++ + ++ W EG L G K IG FP YV+L I +P Sbjct: 1093 ---LTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPP 1149 Query: 331 PAAA 334 + A Sbjct: 1150 KSTA 1153 Score = 50.8 bits (120), Expect = 5e-06 Identities = 83/365 (22%), Positives = 130/365 (35%), Gaps = 71/365 (19%) Query: 198 YGKALYSYEGKEPGDLKFNKGDIIVLRRK-VDEQ------WYHGELHGTQGFLPASYIQC 250 Y +ALY +E + ++ GDI++++ + VDE W GEL G G+ PA+Y + Sbjct: 744 YYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEK 803 Query: 251 IQ----PLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKI 306 I P P P + L T E T NWA D Sbjct: 804 IPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPST----TPNNWA-----DFS 854 Query: 307 GIFPLLYVELNDSAKQLIEMDKP---CPAAASSCNASLPSDSGAVASVAPSPTLSSSGAV 363 +P E ++ +P P+A S + + A S +PSP L V Sbjct: 855 STWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGS-SPSPVLGQGEKV 913 Query: 364 SAFQRRV--------DGKKNTKKRHSFTALSVTHR--SSQAASHRHSMEISAPVLISSSD 413 Q + D N K T L + + S LIS Sbjct: 914 EGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPI 973 Query: 414 PRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAAS------VSGEQGTPPKVQLPLN 467 ++ + + S + +P ++ R AS VSGE+ Sbjct: 974 RKSTS----------------MDSGSSESPASLKRVASPAAKPVVSGEE----------- 1006 Query: 468 VYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVP 527 ++A+Y Y+ + +L +G++ V +K D W + +GVFP NYV Sbjct: 1007 -FIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDK---AGVFPSNYVRLKDSEG 1062 Query: 528 AGGAG 532 +G AG Sbjct: 1063 SGTAG 1067 Score = 47.8 bits (112), Expect = 5e-05 Identities = 77/318 (24%), Positives = 119/318 (37%), Gaps = 67/318 (21%) Query: 262 KALYDFEMKDKDQ---DKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELND 318 +ALY FE + D+ + K E + + + W G L K G FP Y E Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE--- 802 Query: 319 SAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKK 378 ++ E + P P + + S P+ A+ P+P +S S Sbjct: 803 ---KIPENEVPAPVKPVTDSTSAPAPKLALRET-PAPLAVTSSEPST---------TPNN 849 Query: 379 RHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSS 438 F++ T + + + + P L S G L S P +++ Sbjct: 850 WADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPS-------AGQLRQRSAFTP----ATA 898 Query: 439 AGSTPTAV-PRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKC 497 GS+P+ V + V G Q ALY ++ +K + L +K ++ VLE+ Sbjct: 899 TGSSPSPVLGQGEKVEGLQAQ------------ALYPWRAKKDNHLNFNKNDVITVLEQ- 945 Query: 498 QDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSG 557 QD W+ G G G FP +YV +S GP R +T+M SG Sbjct: 946 QDMWWFGEV--QGQKGWFPKSYVKLIS-------GPIRK------------STSM--DSG 982 Query: 558 SLSSLATATRPALPITTP 575 S S A+ R A P P Sbjct: 983 SSESPASLKRVASPAAKP 1000 Score = 47.4 bits (111), Expect = 6e-05 Identities = 98/439 (22%), Positives = 158/439 (35%), Gaps = 76/439 (17%) Query: 469 YLALYAYKPQKSDELELHKGEMYRVLEKCQD-------GWFKGASLRTGVSGVFPGNYVT 521 Y ALY ++ + DE+ + G++ V + D GW G L+ G +G FP NY Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWL-GGELK-GKTGWFPANYAE 802 Query: 522 PVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQH 581 + P N V +P+ +T P LA PA P A Sbjct: 803 KI----------PENEVP--APVKPVTDSTSAPAP----KLALRETPA-----PLAVTSS 841 Query: 582 PTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATV---SPLRTQNSPSRLP 638 ++ P S PT++ + AAQ P+ TV LR +++ + Sbjct: 842 EPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQ----PSLTVPSAGQLRQRSAFTPAT 897 Query: 639 ATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLS 698 AT P V+ Q +Q A A+ P N I VL Sbjct: 898 ATGSSPSPVLG-QGEKVEGLQ------------AQALYPWRAKKDNHLNFNKNDVITVLE 944 Query: 699 TSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSR-SPPSVSPTHDPQVAVDALLQ 757 G E + +K +KL++G K S S S SP +VA A Sbjct: 945 QQDMWWFG----EVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKP 1000 Query: 758 GAVGPEVSSLSIHGRA---------GSCPIESEMQGAMGMEPLHRKAGSLDLNFT----S 804 G E ++ + + G + ++ G + KAG N+ S Sbjct: 1001 VVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDS 1060 Query: 805 PSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGT 864 ++ +P++ +V+ SY ++ L G ++ + KK GW++G Sbjct: 1061 EGSGTAGKTGSLGKKPEIA-----QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGE 1115 Query: 865 LQRNGR---TGLFPGSFVE 880 LQ G+ G FP ++V+ Sbjct: 1116 LQARGKKRQIGWFPANYVK 1134 Score = 43.1 bits (100), Expect = 0.001 Identities = 21/51 (41%), Positives = 28/51 (54%), Gaps = 2/51 (3%) Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520 + +Y Y Q DEL +KG++ VL K W+KG G G+FP NYV Sbjct: 1161 IGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV--NGQVGLFPSNYV 1209 Score = 39.3 bits (90), Expect = 0.016 Identities = 17/47 (36%), Positives = 29/47 (61%), Gaps = 2/47 (4%) Query: 834 YPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 Y Q++ E+ +G I+ V K + W+KG + NG+ GLFP ++V+ Sbjct: 1166 YTAQNDDELAFNKGQIINVLNKEDPDWWKGEV--NGQVGLFPSNYVK 1210 Score = 36.6 bits (83), Expect = 0.11 Identities = 28/87 (32%), Positives = 41/87 (47%), Gaps = 13/87 (14%) Query: 805 PSRQAPLSMAAIRP----EPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFV-------H 853 P+ QAP S A P + + YR + + +S EI ++ GDIV V Sbjct: 718 PAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDES 777 Query: 854 KKREDGWYKGTLQRNGRTGLFPGSFVE 880 + E GW G L+ G+TG FP ++ E Sbjct: 778 QTGEPGWLGGELK--GKTGWFPANYAE 802 >gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens] Length = 352 Score = 68.6 bits (166), Expect = 3e-11 Identities = 28/60 (46%), Positives = 39/60 (65%) Query: 197 PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPH 256 P +ALY +E + G+L F +GDII L ++DE WY G LHG GF P +Y++ + LPH Sbjct: 293 PCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH 352 Score = 51.6 bits (122), Expect = 3e-06 Identities = 25/58 (43%), Positives = 38/58 (65%), Gaps = 4/58 (6%) Query: 259 PQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVEL 316 P +ALYDFE +++ + L F + +I+T+ ++DENW EGML G FP+ YVE+ Sbjct: 293 PCCRALYDFEPENEGE----LGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEI 346 Score = 45.4 bits (106), Expect = 2e-04 Identities = 19/52 (36%), Positives = 34/52 (65%), Gaps = 2/52 (3%) Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 R + + P++E E+ KEGDI+ + + ++ WY+G L +G +G FP ++VE Sbjct: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGML--HGHSGFFPINYVE 345 Score = 42.4 bits (98), Expect = 0.002 Identities = 36/145 (24%), Positives = 64/145 (44%), Gaps = 23/145 (15%) Query: 392 SQAASHRHSMEISAPVLI--------SSSDPRAAARIGDLAHLSCAAPTQDVSS-SAGST 442 +Q H+ +++I V + +SS PR + +S PT D + + G + Sbjct: 221 AQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQ--PKPRMSLEFPTGDSTQPNGGLS 278 Query: 443 PTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWF 502 T P+ P VQ+ ALY ++P+ EL +G++ + + + W+ Sbjct: 279 HTGTPK----------PSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWY 328 Query: 503 KGASLRTGVSGVFPGNYVTPVSRVP 527 +G + G SG FP NYV + +P Sbjct: 329 EG--MLHGHSGFFPINYVEILVALP 351 >gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens] Length = 347 Score = 67.4 bits (163), Expect = 6e-11 Identities = 27/59 (45%), Positives = 38/59 (64%) Query: 197 PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLP 255 P + LY +E + G+L F +GDII L ++DE WY G +HG GF P +Y++ I PLP Sbjct: 288 PCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLP 346 Score = 51.2 bits (121), Expect = 4e-06 Identities = 24/63 (38%), Positives = 40/63 (63%), Gaps = 4/63 (6%) Query: 254 LPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLY 313 +P P + LYDFE +++ + L F + +I+T+ ++DENW EGM+ + G FP+ Y Sbjct: 283 IPMDQPCCRGLYDFEPENQGE----LGFKEGDIITLTNQIDENWYEGMIHGESGFFPINY 338 Query: 314 VEL 316 VE+ Sbjct: 339 VEV 341 Score = 42.4 bits (98), Expect = 0.002 Identities = 17/52 (32%), Positives = 34/52 (65%), Gaps = 2/52 (3%) Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 R + + P+++ E+ KEGDI+ + + ++ WY+G + +G +G FP ++VE Sbjct: 291 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMI--HGESGFFPINYVE 340 Score = 37.4 bits (85), Expect = 0.062 Identities = 17/56 (30%), Positives = 31/56 (55%), Gaps = 2/56 (3%) Query: 472 LYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVP 527 LY ++P+ EL +G++ + + + W++G + G SG FP NYV + +P Sbjct: 293 LYDFEPENQGELGFKEGDIITLTNQIDENWYEG--MIHGESGFFPINYVEVIVPLP 346 >gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo sapiens] Length = 665 Score = 67.0 bits (162), Expect = 7e-11 Identities = 78/355 (21%), Positives = 133/355 (37%), Gaps = 76/355 (21%) Query: 203 YSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQ------PLP- 255 + Y+ + +L + G+II RK D W+ G+++G +G P ++++ I+ PL Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN 67 Query: 256 -------HAPPQGKALYDFE-------------------MKDKDQDKDCLTFTKDEILTV 289 H P G +L E Q+ D L +I+ V Sbjct: 68 KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127 Query: 290 LRRVDENWAEGMLGDKIGIFPLLYV-ELNDSAKQL-IEMDKPCPAAASSCNASLPSDSGA 347 + V+E W EG+L K G+FP ++ EL+ + +L I D+ +SL +G+ Sbjct: 128 VGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDE------QLSKSSLRETTGS 181 Query: 348 VASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPV 407 + S + S GA K K + S+E+ Sbjct: 182 ESDGGDSSSTKSEGANGTVATAAIQPKKVKG----VGFGDIFKDKPIKLRPRSIEVENDF 237 Query: 408 LISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLN 467 L P + TA P ++ + T K + Sbjct: 238 L----------------------PVEKTIGKKLPATTATPDSSKTEMDSRTKSK-----D 270 Query: 468 VYLALYAYKPQKSDELELHKGEMYRVLEK-CQD-GWFKGASLRTGVSGVFPGNYV 520 ++ Y+ Q DEL + +G++ ++ K C D GW++G G GVFP N+V Sbjct: 271 YCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGE--LNGRRGVFPDNFV 323 Score = 65.5 bits (158), Expect = 2e-10 Identities = 46/116 (39%), Positives = 65/116 (56%), Gaps = 7/116 (6%) Query: 769 IHGRAGSCP--IESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRE 826 I+GR G P E++ M +PL KA L+ PS + LS I K R Sbjct: 41 INGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEV-PSGNSLLSSETILRTNKRGERR 99 Query: 827 RYR--VVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880 R R V SY PQ++ E+ELK GDI+ V + E+GW++G L NG+TG+FP +F++ Sbjct: 100 RRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVL--NGKTGMFPSNFIK 153 Score = 46.2 bits (108), Expect = 1e-04 Identities = 19/52 (36%), Positives = 35/52 (67%), Gaps = 2/52 (3%) Query: 473 YAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVS 524 ++Y PQ DELEL G++ V+ + ++GW++G + G +G+FP N++ +S Sbjct: 107 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEG--VLNGKTGMFPSNFIKELS 156 Score = 45.8 bits (107), Expect = 2e-04 Identities = 19/58 (32%), Positives = 34/58 (58%), Gaps = 2/58 (3%) Query: 198 YGKALYSYEGKEPGDLKFNKGDIIVLRRK--VDEQWYHGELHGTQGFLPASYIQCIQP 253 Y K ++ YE + +L +GDI+ L K +D W+ GEL+G +G P ++++ + P Sbjct: 271 YCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPP 328 Score = 45.1 bits (105), Expect = 3e-04 Identities = 25/78 (32%), Positives = 44/78 (56%), Gaps = 4/78 (5%) Query: 805 PSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR--EDGWYK 862 P+ A + + + ++ +V+ Y Q++ E+ +KEGDIV + K + GW++ Sbjct: 249 PATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWE 308 Query: 863 GTLQRNGRTGLFPGSFVE 880 G L NGR G+FP +FV+ Sbjct: 309 GEL--NGRRGVFPDNFVK 324 Score = 41.2 bits (95), Expect = 0.004 Identities = 20/50 (40%), Positives = 30/50 (60%), Gaps = 2/50 (4%) Query: 830 VVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFV 879 V Y Q + E+ + G+I+ +K + GW++G Q NGR GLFP +FV Sbjct: 6 VEFDYQAQHDDELTISVGEIITNIRKEDGGWWEG--QINGRRGLFPDNFV 53 Score = 40.0 bits (92), Expect = 0.010 Identities = 23/89 (25%), Positives = 42/89 (47%), Gaps = 5/89 (5%) Query: 161 PGSPVFLSAAAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDI 220 P P+ + S S L T++ + C + +SY + +L+ GDI Sbjct: 70 PEKPLHEVPSGNSLLSSETILRTNKRGERRRRRC-----QVAFSYLPQNDDELELKVGDI 124 Query: 221 IVLRRKVDEQWYHGELHGTQGFLPASYIQ 249 I + +V+E W+ G L+G G P+++I+ Sbjct: 125 IEVVGEVEEGWWEGVLNGKTGMFPSNFIK 153 Score = 36.2 bits (82), Expect = 0.14 Identities = 28/91 (30%), Positives = 42/91 (46%), Gaps = 14/91 (15%) Query: 258 PPQGKALYDFEMKDKD----------QDKDCLTFTKDEILTVLRR--VDENWAEGMLGDK 305 P K D K KD Q+ D LT + +I+T++ + +D W EG L + Sbjct: 255 PDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGR 314 Query: 306 IGIFPLLYVEL--NDSAKQLIEMDKPCPAAA 334 G+FP +V+L D K+ KP P +A Sbjct: 315 RGVFPDNFVKLLPPDFEKEGNRPKKPPPPSA 345 Score = 35.4 bits (80), Expect = 0.23 Identities = 17/53 (32%), Positives = 28/53 (52%), Gaps = 2/53 (3%) Query: 473 YAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSR 525 + Y+ Q DEL + GE+ + K GW++G G G+FP N+V + + Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQI--NGRRGLFPDNFVREIKK 58 >gi|119943102 CREB binding protein isoform b [Homo sapiens] Length = 2404 Score = 63.9 bits (154), Expect = 6e-10 Identities = 105/439 (23%), Positives = 170/439 (38%), Gaps = 64/439 (14%) Query: 414 PRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALY 473 PRAA+ + ++ ++ S P+ +P+ ++ G Q P Sbjct: 703 PRAASPMNHSVQMNSMGSVPGMAIS----PSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQ 758 Query: 474 AYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNY---VTPVSRVPAGG 530 P S + + G+ Q G GA+L ++ + P PV++ P Sbjct: 759 NQFPSSSGAMSVGMGQPPAQTGVSQ-GQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHP 817 Query: 531 AGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQHPTASPPTGS 590 PP + G L M P A T+P+ P+++ Q PT +P Sbjct: 818 TPPPASTAAGMPSLQHTTPPGMTPPQP-----AAPTQPSTPVSSS---GQTPTPTP---- 865 Query: 591 CLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSP 650 + P+A+Q +ST + A AAQAQ P P T ++P SV +P Sbjct: 866 ----GSVPSATQTQSTPTVQA--AAQAQVTPQ---------------PQTPVQPPSVATP 904 Query: 651 QHSHQPPVQM-CPRPAIPLTSAASAI-----TPPNVSAANLNGEAGGGPIGVLSTSSPTN 704 Q S Q P + P PL+ AA++I TP +V++A N + G + VL + T Sbjct: 905 QSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQ 964 Query: 705 TGCKLDEKKSEKKEKKSGLLKL-LAGASTKK------KSRSPPSVSPTHDPQVAVDALLQ 757 + K E +S +++ L GAS K + +S P P+V V+ Sbjct: 965 AEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEV--- 1021 Query: 758 GAVGPEVSSLSIHGRAGSCPIESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIR 817 E S +G A S+ + + R+A L + RQ P S+ + Sbjct: 1022 ----KEEEESSSNGTASQSTSPSQPRKKIFKPEELRQA--LMPTLEALYRQDPESLPFRQ 1075 Query: 818 P-EPKLLPRERYRVVVSYP 835 P +P+LL Y +V P Sbjct: 1076 PVDPQLLGIPDYFDIVKNP 1094 Score = 32.0 bits (71), Expect = 2.6 Identities = 30/113 (26%), Positives = 46/113 (40%), Gaps = 11/113 (9%) Query: 534 PRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQHPTASP-----PT 588 P+ +++ G P A + PG +SL+ R P+ +P+ +Q P +SP P Sbjct: 2278 PQQHMLSGQPQASHL-----PGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQ 2332 Query: 589 GSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATS 641 S H + T S T A S Q + L N+PSR +S Sbjct: 2333 PS-PHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSS 2384 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.313 0.129 0.382 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 40,054,407 Number of Sequences: 37866 Number of extensions: 2218825 Number of successful extensions: 16345 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 319 Number of HSP's successfully gapped in prelim test: 894 Number of HSP's that attempted gapping in prelim test: 12030 Number of HSP's gapped (non-prelim): 4585 length of query: 882 length of database: 18,247,518 effective HSP length: 111 effective length of query: 771 effective length of database: 14,044,392 effective search space: 10828226232 effective search space used: 10828226232 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.