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Search of human proteins with 150010572
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
(882 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 1766 0.0
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 724 0.0
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 361 1e-99
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 139 9e-33
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 134 3e-31
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 128 3e-29
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 92 2e-18
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 91 5e-18
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 91 5e-18
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 91 5e-18
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 91 5e-18
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 91 5e-18
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 91 5e-18
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 91 5e-18
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 91 5e-18
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 88 3e-17
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 88 3e-17
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 88 3e-17
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 88 4e-17
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 84 8e-16
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 84 8e-16
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 84 8e-16
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 84 8e-16
gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens] 76 1e-13
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 72 2e-12
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 72 2e-12
gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens] 69 3e-11
gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens] 67 6e-11
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 67 7e-11
gi|119943102 CREB binding protein isoform b [Homo sapiens] 64 6e-10
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 1766 bits (4575), Expect = 0.0
Identities = 882/882 (100%), Positives = 882/882 (100%)
Query: 1 MLLGASWLCASKAAAAAAQSEGDEDRPGERRRRRAAATAAGAGEDMDESSLLDLLECSVC 60
MLLGASWLCASKAAAAAAQSEGDEDRPGERRRRRAAATAAGAGEDMDESSLLDLLECSVC
Sbjct: 1 MLLGASWLCASKAAAAAAQSEGDEDRPGERRRRRAAATAAGAGEDMDESSLLDLLECSVC 60
Query: 61 LERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDG 120
LERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDG
Sbjct: 61 LERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDG 120
Query: 121 IRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRE 180
IRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRE
Sbjct: 121 IRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRE 180
Query: 181 LATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ 240
LATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ
Sbjct: 181 LATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ 240
Query: 241 GFLPASYIQCIQPLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEG 300
GFLPASYIQCIQPLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEG
Sbjct: 241 GFLPASYIQCIQPLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEG 300
Query: 301 MLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSS 360
MLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSS
Sbjct: 301 MLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSS 360
Query: 361 GAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARI 420
GAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARI
Sbjct: 361 GAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARI 420
Query: 421 GDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKS 480
GDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKS
Sbjct: 421 GDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKS 480
Query: 481 DELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVG 540
DELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVG
Sbjct: 481 DELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVG 540
Query: 541 GSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTA 600
GSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTA
Sbjct: 541 GSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTA 600
Query: 601 SQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQM 660
SQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQM
Sbjct: 601 SQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQM 660
Query: 661 CPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKK 720
CPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKK
Sbjct: 661 CPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKK 720
Query: 721 SGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRAGSCPIES 780
SGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRAGSCPIES
Sbjct: 721 SGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRAGSCPIES 780
Query: 781 EMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEA 840
EMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEA
Sbjct: 781 EMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEA 840
Query: 841 EIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF 882
EIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF
Sbjct: 841 EIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF 882
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 724 bits (1868), Expect = 0.0
Identities = 442/930 (47%), Positives = 543/930 (58%), Gaps = 137/930 (14%)
Query: 46 MDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGV 105
MDES+LLDLLEC VCLERLD +AKVLPCQHTFC+RCL IV SR+ELRCPECR LVG GV
Sbjct: 1 MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGV 60
Query: 106 DELPANILLVRLLDGIRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPV 165
+ELP+NILLVRLLDGI+QRP GGS G + L A +
Sbjct: 61 EELPSNILLVRLLDGIKQRPWKPGPGGGS-------GTNCTNALRSQSSTVANCS----- 108
Query: 166 FLSAAAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRR 225
S S+ G + S + P P LP KALY+YEGKEPGDLKF+KGDII+LRR
Sbjct: 109 --SKDLQSSQGGQQPRVQSWSPPVRGIP-QLPCAKALYNYEGKEPGDLKFSKGDIIILRR 165
Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDE 285
+VDE WYHGE++G GF P +++Q I+PLP PPQ KALYDFE+KDK+ DKDCL F KD+
Sbjct: 166 QVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDD 225
Query: 286 ILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDS 345
+LTV+RRVDENWAEGML DKIGIFP+ YVE N +AKQLIE DKP +A S +
Sbjct: 226 VLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKP---PVPGVDAGECSSA 282
Query: 346 GAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISA 405
A +S AP + D KKNTKKRHSFT+L++ ++SSQA+ +RHSMEIS
Sbjct: 283 AAQSSTAP--------------KHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISP 328
Query: 406 PVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGT------- 458
PVLISSS+P AAARI +L+ LSC+AP+Q S+ G T P + +G T
Sbjct: 329 PVLISSSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPSDVPY 388
Query: 459 --------PPKVQLPL-------------------------------------------N 467
PP PL +
Sbjct: 389 QAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPS 448
Query: 468 VYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSR-- 525
VY+A+Y Y P+K DELEL KGEM+ V E+CQDGWFKG S+ T GVFPGNYV PV+R
Sbjct: 449 VYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAV 508
Query: 526 -------VPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAH 578
VP AG V SP G G+G S + PA ++
Sbjct: 509 TNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNGVAGSPSVV--PAAVVS----- 561
Query: 579 AQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLP 638
A H SP L + Q T +QAR+ + T A A Q+RPTA V+P++ QN+ P
Sbjct: 562 AAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVA---AHNQERPTAAVTPIQVQNAAGLSP 618
Query: 639 AT-SLRPHSVVSPQHSHQPPVQMCPRPAI-------PLTSAASA-ITPPNVSAANLNGEA 689
A+ L HS+ SPQ + P AI PL AA+A +T P++++A+L E
Sbjct: 619 ASVGLSHHSLASPQPAPLMPGSATHTAAISISRASAPLACAAAAPLTSPSITSASLEAEP 678
Query: 690 GGGPIGVL--------STSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSRSPPS 741
G + VL S SS K KKEKK GLLKLL+GASTK+K R P
Sbjct: 679 SGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKKEKK-GLLKLLSGASTKRKPRVSPP 737
Query: 742 VSPTHDPQVAVDAL-LQGAVGPEVSSLSIHGRAGSCPIESE-------MQGAMGMEPLHR 793
SPT + ++ L LQGAVGPE+ HGRAGSCP++ + A+ + HR
Sbjct: 738 ASPTLEVELGSAELPLQGAVGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHR 797
Query: 794 KAGSLD--LNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVF 851
KA SLD + P RQA S+ + E + + ER+RVVVSYPPQSEAE+ELKEGDIVF
Sbjct: 798 KASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVF 857
Query: 852 VHKKREDGWYKGTLQRNGRTGLFPGSFVES 881
VHKKREDGW+KGTLQRNG+TGLFPGSFVE+
Sbjct: 858 VHKKREDGWFKGTLQRNGKTGLFPGSFVEN 887
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 361 bits (927), Expect = 1e-99
Identities = 258/755 (34%), Positives = 371/755 (49%), Gaps = 94/755 (12%)
Query: 46 MDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGV 105
MD+ +LLDLLEC VC E+LD TAKVLPCQHTFC+ CL+ + + ELRCPECR V +
Sbjct: 1 MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRVFKAHKELRCPECRTPVFSNI 60
Query: 106 DELPANILLVRLLDGIRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPV 165
+ LPAN+LLVRLLDG+R GQS+ G G + PG+
Sbjct: 61 EALPANLLLVRLLDGVRS------------------GQSS-------GRGGSFRRPGTMT 95
Query: 166 FLSAAAGSTAGSLRELATSRTAPAAK-NPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLR 224
T + + R P + + +P KAL +Y G+ PGDL+FNKGDII+LR
Sbjct: 96 LQDGRKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLR 155
Query: 225 RKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPPQGKALYDFEM--KDKDQDKDCLTFT 282
R++DE WY GE++G G PAS ++ I+ LP PP +ALY+F++ KDK +++DCLTF
Sbjct: 156 RQLDENWYQGEINGISGNFPASSVEVIKQLPQPPPLCRALYNFDLRGKDKSENQDCLTFL 215
Query: 283 KDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLP 342
KD+I+TV+ RVDENWAEG LGDK+GIFP+L+VE N +A+ L+E +K ++ + N SL
Sbjct: 216 KDDIITVISRVDENWAEGKLGDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTK-NLSLV 274
Query: 343 SDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSF-TALSVTHRSSQAASHRHSM 401
S SS G S +R ++ + S TAL+ +R + S RH +
Sbjct: 275 SS-------------SSRGNTSTLRRGPGSRRKVPGQFSITTALNTLNRMVHSPSGRHMV 321
Query: 402 EISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPK 461
EIS PVLISSS+P + + A + P+ V + P V S + +
Sbjct: 322 EISTPVLISSSNPSVITQPMEKADV----PSSCVGQVSTYHPAPVSPGHSTAVVSLPGSQ 377
Query: 462 VQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVT 521
L N+++AL++Y DEL+L KGE RVL KCQDGW +G SL TG G+FP NYV
Sbjct: 378 QHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVI 437
Query: 522 PVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLAT-------ATRPALPITT 574
P+ R + + G+ TT + S+SS + +RP +
Sbjct: 438 PIFRKTSSFP----------DSRSPGLYTTWTLSTSSVSSQGSISEGDPRQSRPFKSVFV 487
Query: 575 PQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSP 634
P A ++ G+ + S + S R S RP + P S
Sbjct: 488 PTAIVNPVRSTAGPGTLGQGSLRKGRSSMRKNGSL---------QRPLQSGIPTLVVGSL 538
Query: 635 SRLPATSLRPH--SVVSPQHSHQPP----VQMCPRPAIPLTSAASAITPPNVSAANLNGE 688
R P LRP PQ P V+M +PA+ A + I+ S A ++
Sbjct: 539 RRSPTMVLRPQQFQFYQPQGIPSSPSAVVVEMGSKPALTGEPALTCIS--RGSEARIHSA 596
Query: 689 AG------------GGPIGVLSTSSPTNTGCKLDEKKSE-KKEKKSGLLKLLAGASTKKK 735
A P+ S+P + K + ++ +K+ K+ + + TK
Sbjct: 597 ASSLIMEDKEIPIKSEPLPKPPASAPPSILVKPENSRNGIEKQVKTVRFQNYSPPPTKHY 656
Query: 736 SRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIH 770
+ P S P + ++GPE++ L H
Sbjct: 657 TSHPTSGKPEQPATLKASQPEAASLGPEMTVLFAH 691
Score = 41.2 bits (95), Expect = 0.004
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 14/97 (14%)
Query: 793 RKAGSLDLNFTSPSRQAPLSMAAIRPEP-KLLPRERY--------RVVVSYPPQSEAEIE 843
R+ G++ L SR P + A P +L+P R + + +Y Q+ ++
Sbjct: 89 RRPGTMTLQDGRKSRTNPRRLQA---SPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLR 145
Query: 844 LKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
+GDI+ + ++ ++ WY+G + NG +G FP S VE
Sbjct: 146 FNKGDIILLRRQLDENWYQGEI--NGISGNFPASSVE 180
Score = 40.0 bits (92), Expect = 0.010
Identities = 18/47 (38%), Positives = 28/47 (59%)
Query: 833 SYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFV 879
SY E++L++G+ V V K +DGW +G GR G+FP ++V
Sbjct: 390 SYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 139 bits (351), Expect = 9e-33
Identities = 108/351 (30%), Positives = 166/351 (47%), Gaps = 49/351 (13%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
+A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P
Sbjct: 821 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 880
Query: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLG--DKIG 307
+ G+A+ F Q + ++F K E +T+LR+VDENW EG + + G
Sbjct: 881 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 938
Query: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVS 364
IFP+ YV++ K ++ MD P +S PS S A+ +P P SG
Sbjct: 939 IFPITYVDVIKRPLVKNPVDYMDLPF--------SSSPSRS---ATASPQPWREESGQYE 987
Query: 365 ------AFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAA 418
A +R G K +KK + L + ++ + +++ P + R
Sbjct: 988 RKAERGAGERGPGGPKISKK----SCLKPSDVVRCLSTEQRLSDLNTP-----EESRPGK 1038
Query: 419 RIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGE----QGTPPKVQLPLNV--YLAL 472
+G S A T+ + A R S + + TP + Q ++ Y AL
Sbjct: 1039 PLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQAL 1098
Query: 473 YAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523
Y+Y PQ DELEL G++ V+EKC DGWF G S RT G FPGNYV P+
Sbjct: 1099 YSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
Score = 59.3 bits (142), Expect = 2e-08
Identities = 25/53 (47%), Positives = 40/53 (75%)
Query: 828 YRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Y+ + SY PQ++ E+EL++GDIV V +K +DGW+ GT +R + G FPG++V+
Sbjct: 1095 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1147
Score = 45.8 bits (107), Expect = 2e-04
Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E
Sbjct: 821 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 870
Score = 37.0 bits (84), Expect = 0.081
Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505
+P A ++ TP +V L +A + + E+ KGE +L + + W++G
Sbjct: 872 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 930
Query: 506 SLRTGVSGVFPGNYVTPVSR 525
T G+FP YV + R
Sbjct: 931 IPGTSRQGIFPITYVDVIKR 950
Score = 33.1 bits (74), Expect = 1.2
Identities = 10/43 (23%), Positives = 28/43 (65%)
Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+
Sbjct: 904 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 946
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 134 bits (338), Expect = 3e-31
Identities = 112/423 (26%), Positives = 178/423 (42%), Gaps = 73/423 (17%)
Query: 122 RQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTP------GSPVFLSAAAGSTA 175
+ P +P PPA P S++ A G A +P GSP FL
Sbjct: 301 KSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSP-FLGRRDFVYP 359
Query: 176 GSLRELATSRT--APAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYH 233
S R+ + S +PA + + + ++ + P +L KGDI+ + ++VD+ W
Sbjct: 360 SSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLE 419
Query: 234 GELHGTQGFLPASYIQCIQ----PLPHAPP------QGKALYDFEMKDKDQDKDCLTFTK 283
GE HG G PA+Y++ + P P PP G+A+ + K + + L+F K
Sbjct: 420 GEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVE--LSFRK 477
Query: 284 DEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASL 341
E + ++R+V+ENW EG + + GIFP YV+++ + + D P L
Sbjct: 478 GEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGP----------QL 527
Query: 342 PSDSGAVASVAPSPTLSSSGAVSAFQRRVD-GKKNTKKRHSFTALSVTHRSSQAASHRHS 400
P+ A+ + SS A+ + +D G + + +R F + + + +
Sbjct: 528 PTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGF-----SFPTQEPRPQTQN 582
Query: 401 MEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPP 460
+ P L S P +G +P
Sbjct: 583 LGTPGPALSHSRGPSHPLDLG----------------------------------TSSPN 608
Query: 461 KVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
Q+ Y A+Y Y+PQ DELEL +G+ V+++C DGWF G S RT G FPGNYV
Sbjct: 609 TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
Query: 521 TPV 523
PV
Sbjct: 669 APV 671
Score = 58.9 bits (141), Expect = 2e-08
Identities = 27/70 (38%), Positives = 41/70 (58%)
Query: 810 PLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNG 869
PL + P + YR + Y PQ+E E+EL+EGD V V ++ +DGW+ G +R
Sbjct: 599 PLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQ 658
Query: 870 RTGLFPGSFV 879
+ G FPG++V
Sbjct: 659 KFGTFPGNYV 668
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 9/89 (10%)
Query: 796 GSLDLNFTSPSRQAPLSMA----AIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVF 851
G D + S +R S A R E K R+ R+ + QS E+ L++GDIV+
Sbjct: 352 GRRDFVYPSSTRDPSASNGGGSPARREEKK---RKAARLKFDFQAQSPKELTLQKGDIVY 408
Query: 852 VHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
+HK+ + W +G + +GR G+FP ++VE
Sbjct: 409 IHKEVDKNWLEG--EHHGRLGIFPANYVE 435
Score = 48.1 bits (113), Expect = 4e-05
Identities = 47/185 (25%), Positives = 67/185 (36%), Gaps = 16/185 (8%)
Query: 459 PPKVQ-LPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPG 517
PP Q L +A Y +K EL KGE ++ K + W++G TG G+FP
Sbjct: 448 PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPA 507
Query: 518 NYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGS----------LSSLATATR 567
+YV VSR P + L + HP S S L + R
Sbjct: 508 SYV-QVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRR 566
Query: 568 PALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSP 627
T + Q P G L HS P+ + T++ + +Q P +
Sbjct: 567 TGFSFPTQEPRPQTQNLGTP-GPALSHSRGPSHP---LDLGTSSPNTSQIHWTPYRAMYQ 622
Query: 628 LRTQN 632
R QN
Sbjct: 623 YRPQN 627
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/93 (27%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 792 HRKAGSLDLNFTS--PSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIEL--KEG 847
H + G N+ P+ + P I+P P E V Y + + E+EL ++G
Sbjct: 423 HGRLGIFPANYVEVLPADEIP---KPIKP-PTYQVLEYGEAVAQYTFKGDLEVELSFRKG 478
Query: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
+ + + +K + WY+G + GR G+FP S+V+
Sbjct: 479 EHICLIRKVNENWYEGRITGTGRQGIFPASYVQ 511
Score = 33.5 bits (75), Expect = 0.89
Identities = 17/57 (29%), Positives = 28/57 (49%), Gaps = 4/57 (7%)
Query: 473 YAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNY--VTPVSRVP 527
+ ++ Q EL L KG++ + ++ W +G G G+FP NY V P +P
Sbjct: 389 FDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGE--HHGRLGIFPANYVEVLPADEIP 443
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 128 bits (321), Expect = 3e-29
Identities = 93/350 (26%), Positives = 152/350 (43%), Gaps = 64/350 (18%)
Query: 187 APAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPAS 246
+PA + + + ++ + P +L KGDI+ + ++VD+ W GE HG G PA+
Sbjct: 31 SPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPAN 90
Query: 247 YIQCIQ----PLPHAPP------QGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDEN 296
Y++ + P P PP G+A+ + K + + L+F K E + ++R+V+EN
Sbjct: 91 YVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVE--LSFRKGEHICLIRKVNEN 148
Query: 297 WAEGML--GDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPS 354
W EG + + GIFP YV+++ + + D P LP+ A+ +
Sbjct: 149 WYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGP----------QLPTSPRLTAAARSA 198
Query: 355 PTLSSSGAVSAFQRRVD-GKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSD 413
SS A+ + +D G + + +R F + + + ++ P L S
Sbjct: 199 RHPSSPSALRSPADPIDLGGQTSPRRTGF-----SFPTQEPRPQTQNLGTPGPALSHSRG 253
Query: 414 PRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALY 473
P +G +P Q+ Y A+Y
Sbjct: 254 PSHPLDLG----------------------------------TSSPNTSQIHWTPYRAMY 279
Query: 474 AYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523
Y+PQ DELEL +G+ V+++C DGWF G S RT G FPGNYV PV
Sbjct: 280 QYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
Score = 58.9 bits (141), Expect = 2e-08
Identities = 27/70 (38%), Positives = 41/70 (58%)
Query: 810 PLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNG 869
PL + P + YR + Y PQ+E E+EL+EGD V V ++ +DGW+ G +R
Sbjct: 257 PLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQ 316
Query: 870 RTGLFPGSFV 879
+ G FPG++V
Sbjct: 317 KFGTFPGNYV 326
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 9/89 (10%)
Query: 796 GSLDLNFTSPSRQAPLSMA----AIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVF 851
G D + S +R S A R E K R+ R+ + QS E+ L++GDIV+
Sbjct: 10 GRRDFVYPSSTRDPSASNGGGSPARREEKK---RKAARLKFDFQAQSPKELTLQKGDIVY 66
Query: 852 VHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
+HK+ + W +G + +GR G+FP ++VE
Sbjct: 67 IHKEVDKNWLEG--EHHGRLGIFPANYVE 93
Score = 48.1 bits (113), Expect = 4e-05
Identities = 47/185 (25%), Positives = 67/185 (36%), Gaps = 16/185 (8%)
Query: 459 PPKVQ-LPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPG 517
PP Q L +A Y +K EL KGE ++ K + W++G TG G+FP
Sbjct: 106 PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPA 165
Query: 518 NYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGS----------LSSLATATR 567
+YV VSR P + L + HP S S L + R
Sbjct: 166 SYV-QVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRR 224
Query: 568 PALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSP 627
T + Q P G L HS P+ + T++ + +Q P +
Sbjct: 225 TGFSFPTQEPRPQTQNLGTP-GPALSHSRGPSHP---LDLGTSSPNTSQIHWTPYRAMYQ 280
Query: 628 LRTQN 632
R QN
Sbjct: 281 YRPQN 285
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/93 (27%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 792 HRKAGSLDLNFTS--PSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIEL--KEG 847
H + G N+ P+ + P I+P P E V Y + + E+EL ++G
Sbjct: 81 HGRLGIFPANYVEVLPADEIP---KPIKP-PTYQVLEYGEAVAQYTFKGDLEVELSFRKG 136
Query: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
+ + + +K + WY+G + GR G+FP S+V+
Sbjct: 137 EHICLIRKVNENWYEGRITGTGRQGIFPASYVQ 169
Score = 34.3 bits (77), Expect = 0.52
Identities = 20/81 (24%), Positives = 37/81 (45%), Gaps = 3/81 (3%)
Query: 170 AAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDE 229
A + G L ++P PY +A+Y Y + +L+ +GD + + ++ D+
Sbjct: 247 ALSHSRGPSHPLDLGTSSPNTSQIHWTPY-RAMYQYRPQNEDELELREGDRVDVMQQCDD 305
Query: 230 QWYHGELHGTQ--GFLPASYI 248
W+ G TQ G P +Y+
Sbjct: 306 GWFVGVSRRTQKFGTFPGNYV 326
Score = 33.5 bits (75), Expect = 0.89
Identities = 17/57 (29%), Positives = 28/57 (49%), Gaps = 4/57 (7%)
Query: 473 YAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNY--VTPVSRVP 527
+ ++ Q EL L KG++ + ++ W +G G G+FP NY V P +P
Sbjct: 47 FDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGE--HHGRLGIFPANYVEVLPADEIP 101
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 92.4 bits (228), Expect = 2e-18
Identities = 84/274 (30%), Positives = 124/274 (45%), Gaps = 32/274 (11%)
Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321
+A +DF K Q L K +I+ + +++D+NW EG ++GIFP Y+EL A+
Sbjct: 650 RAKFDF----KAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 705
Query: 322 QLIEMDKPCPAAASSCNASLPS-----DSGAVASVAPSPTLSSSGAVSA--FQRRVDGKK 374
+ + K P ++ D+ S ++ V ++ R+ G
Sbjct: 706 KA-QPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG-- 762
Query: 375 NTKKRHSF--TALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSC-AAP 431
T ++ F T + V R + M++ SSS R+A L+H S A P
Sbjct: 763 -TSRQGIFPITYVDVIKRPL-VKNPVDYMDLP----FSSSPSRSATASPQLSHHSLRAGP 816
Query: 432 TQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNV--YLALYAYKPQKSDELELHKGE 489
S + P A R TP + Q ++ Y ALY+Y PQ DELEL G+
Sbjct: 817 DLTESEKSYVQPQAQQRRV-------TPDRSQTSQDLFSYQALYSYIPQNDDELELRDGD 869
Query: 490 MYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523
+ V+EKC DGWF G S RT G FPGNYV P+
Sbjct: 870 IVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 903
Score = 88.6 bits (218), Expect = 2e-17
Identities = 63/205 (30%), Positives = 101/205 (49%), Gaps = 21/205 (10%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
+A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P
Sbjct: 650 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 709
Query: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307
+ G+A+ F Q + ++F K E +T+LR+VDENW EG + + G
Sbjct: 710 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 767
Query: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAV- 363
IFP+ YV++ K ++ MD P ++ S + P S P T S V
Sbjct: 768 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQ 827
Query: 364 -SAFQRRV--DGKKNTKKRHSFTAL 385
A QRRV D + ++ S+ AL
Sbjct: 828 PQAQQRRVTPDRSQTSQDLFSYQAL 852
Score = 59.3 bits (142), Expect = 2e-08
Identities = 25/53 (47%), Positives = 40/53 (75%)
Query: 828 YRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Y+ + SY PQ++ E+EL++GDIV V +K +DGW+ GT +R + G FPG++V+
Sbjct: 849 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 901
Score = 45.8 bits (107), Expect = 2e-04
Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E
Sbjct: 650 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 699
Score = 41.2 bits (95), Expect = 0.004
Identities = 42/162 (25%), Positives = 59/162 (36%), Gaps = 27/162 (16%)
Query: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505
+P A ++ TP +V L +A + + E+ KGE +L + + W++G
Sbjct: 701 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 759
Query: 506 SLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMH-PGSGSLSSLAT 564
T G+FP YV + R PL K M P S S S AT
Sbjct: 760 IPGTSRQGIFPITYVDVIKR-----------------PLVKNPVDYMDLPFSSSPSRSAT 802
Query: 565 ATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARST 606
A +PQ A P + QP A Q R T
Sbjct: 803 A--------SPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVT 836
Score = 35.8 bits (81), Expect = 0.18
Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
+ALYSY + +L+ GDI+ + K D+ W+ G T+ G P +Y++
Sbjct: 850 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 901
Score = 33.1 bits (74), Expect = 1.2
Identities = 10/43 (23%), Positives = 28/43 (65%)
Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+
Sbjct: 733 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 775
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 90.9 bits (224), Expect = 5e-18
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%)
Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321
KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE
Sbjct: 261 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 310
Query: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381
+L +K PA P+ G + ++ V R+ D K+
Sbjct: 311 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 365
Query: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439
+ ++R + + V + + + A D + H + +SS+
Sbjct: 366 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 420
Query: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499
P GE + ALY Y P+ DELEL + ++ V+EKC D
Sbjct: 421 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 468
Query: 500 GWFKGASLRTGVSGVFPGNYV 520
GWF G S RT G FPGNYV
Sbjct: 469 GWFVGTSRRTKFFGTFPGNYV 489
Score = 89.7 bits (221), Expect = 1e-17
Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%)
Query: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183
R R + P PP R + QSA+ T G PGS L+ + S++ S A
Sbjct: 173 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 226
Query: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225
R +P + + L G KA+Y ++ + +L F KGD + + R
Sbjct: 227 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 286
Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272
K+D+ WY GE HG G P SY++ + P A P + A Y+F
Sbjct: 287 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 346
Query: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328
+ L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D
Sbjct: 347 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 402
Query: 329 PCPAAASS 336
P P + SS
Sbjct: 403 PIPHSYSS 410
Score = 54.7 bits (130), Expect = 4e-07
Identities = 22/55 (40%), Positives = 39/55 (70%)
Query: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+
Sbjct: 436 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
Score = 51.2 bits (121), Expect = 4e-06
Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%)
Query: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469
+SS P + +R D ++ S ST T + R+A +GTP K +LP
Sbjct: 215 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 261
Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526
A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP +
Sbjct: 262 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 318
Query: 527 PAGGAGPPRNNVVGGSPLAK 546
PP G +AK
Sbjct: 319 QPARPPPPAQPGEIGEAIAK 338
Score = 50.8 bits (120), Expect = 5e-06
Identities = 67/290 (23%), Positives = 109/290 (37%), Gaps = 49/290 (16%)
Query: 608 STAAHSAAQAQD-RPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAI 666
S +H AA+ Q RP +S + NSP+ S S V P H P + PR
Sbjct: 53 SAQSHPAAKTQTYRP---LSKSHSDNSPNAFKDAS----SPVPPPHVPPPVPPLRPRDRS 105
Query: 667 PLTSAASAITPPN--VSAANLNGEAGG------GPIGVLSTSSPTNTGCKLDEKKSEKKE 718
++ PP+ V E G +L P + ++ E+
Sbjct: 106 --STEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPM 163
Query: 719 KKSGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRA----G 774
+ + + +K+ +S P+V P +G + +S + GR
Sbjct: 164 SSASM-----ASDFRKRRKSEPAVGPPR------------GLGDQSASRTSPGRVDLPGS 206
Query: 775 SCPIESEMQGAMGMEPLHRK----AGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRV 830
S + + P K S T R AP PE + LP +
Sbjct: 207 STTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT-PEKEKLPA---KA 262
Query: 831 VVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
V + Q+ E+ K+GD V++ +K + WY+G + +GR G+FP S+VE
Sbjct: 263 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVE 310
Score = 48.5 bits (114), Expect = 3e-05
Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838
E E G +G+ P+ S T P + P RP P P E + Y +
Sbjct: 294 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 343
Query: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
+ +EL ++GD V + K+ + WY+G + R G+FP S+VE
Sbjct: 344 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 387
Score = 39.7 bits (91), Expect = 0.012
Identities = 21/76 (27%), Positives = 34/76 (44%)
Query: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518
PP + +A Y + + EL L KG+ +L++ W++G T G+FP +
Sbjct: 325 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 384
Query: 519 YVTPVSRVPAGGAGPP 534
YV V + G P
Sbjct: 385 YVEVVKKNTKGAEDYP 400
Score = 34.3 bits (77), Expect = 0.52
Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
+ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++
Sbjct: 439 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 90.9 bits (224), Expect = 5e-18
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%)
Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321
KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE
Sbjct: 773 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 822
Query: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381
+L +K PA P+ G + ++ V R+ D K+
Sbjct: 823 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 877
Query: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439
+ ++R + + V + + + A D + H + +SS+
Sbjct: 878 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 932
Query: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499
P GE + ALY Y P+ DELEL + ++ V+EKC D
Sbjct: 933 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 980
Query: 500 GWFKGASLRTGVSGVFPGNYV 520
GWF G S RT G FPGNYV
Sbjct: 981 GWFVGTSRRTKFFGTFPGNYV 1001
Score = 81.6 bits (200), Expect = 3e-15
Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 21/154 (13%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
KA+Y ++ + +L F KGD + + RK+D+ WY GE HG G P SY++ + P A P
Sbjct: 773 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 832
Query: 260 -------------QGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GD 304
+ A Y+F + L+ K + + +L+RVD+NW EG + +
Sbjct: 833 ARPPPPAQPGEIGEAIAKYNFNADTNVE----LSLRKGDRVILLKRVDQNWYEGKIPGTN 888
Query: 305 KIGIFPLLYVELNDSAKQLIE--MDKPCPAAASS 336
+ GIFP+ YVE+ + E D P P + SS
Sbjct: 889 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSS 922
Score = 54.7 bits (130), Expect = 4e-07
Identities = 22/55 (40%), Positives = 39/55 (70%)
Query: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+
Sbjct: 948 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
Score = 53.5 bits (127), Expect = 8e-07
Identities = 42/179 (23%), Positives = 74/179 (41%), Gaps = 47/179 (26%)
Query: 180 ELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGT 239
E A P P + A Y++ +L KGD ++L ++VD+ WY G++ GT
Sbjct: 828 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 887
Query: 240 --QGFLPASYIQCIQ------------PLPHA------------PPQG------------ 261
QG P SY++ ++ P+PH+ PQ
Sbjct: 888 NRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 947
Query: 262 ---KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDK--IGIFPLLYVE 315
+ALY++ +++D+ L + +++ V+ + D+ W G G FP YV+
Sbjct: 948 EPFQALYNYTPRNEDE----LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
Score = 52.0 bits (123), Expect = 2e-06
Identities = 46/144 (31%), Positives = 66/144 (45%), Gaps = 17/144 (11%)
Query: 414 PRAAA-RIGDLAHLSC-------AAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLP 465
PR+A+ + D A+ SC A ++ S ST T + R+A +GTP K +LP
Sbjct: 713 PRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLP 771
Query: 466 LNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TP 522
A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP
Sbjct: 772 AK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTP 826
Query: 523 VSRVPAGGAGPPRNNVVGGSPLAK 546
+ PP G +AK
Sbjct: 827 PEKAQPARPPPPAQPGEIGEAIAK 850
Score = 49.3 bits (116), Expect = 2e-05
Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 6/84 (7%)
Query: 797 SLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR 856
S T R AP PE + LP + V + Q+ E+ K+GD V++ +K
Sbjct: 745 SYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSFKKGDTVYILRKI 800
Query: 857 EDGWYKGTLQRNGRTGLFPGSFVE 880
+ WY+G + +GR G+FP S+VE
Sbjct: 801 DQNWYEG--EHHGRVGIFPISYVE 822
Score = 48.5 bits (114), Expect = 3e-05
Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838
E E G +G+ P+ S T P + P RP P P E + Y +
Sbjct: 806 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 855
Query: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
+ +EL ++GD V + K+ + WY+G + R G+FP S+VE
Sbjct: 856 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 899
Score = 39.7 bits (91), Expect = 0.012
Identities = 21/76 (27%), Positives = 34/76 (44%)
Query: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518
PP + +A Y + + EL L KG+ +L++ W++G T G+FP +
Sbjct: 837 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 896
Query: 519 YVTPVSRVPAGGAGPP 534
YV V + G P
Sbjct: 897 YVEVVKKNTKGAEDYP 912
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 90.9 bits (224), Expect = 5e-18
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%)
Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321
KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE
Sbjct: 593 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 642
Query: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381
+L +K PA P+ G + ++ V R+ D K+
Sbjct: 643 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 697
Query: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439
+ ++R + + V + + + A D + H + +SS+
Sbjct: 698 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 752
Query: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499
P GE + ALY Y P+ DELEL + ++ V+EKC D
Sbjct: 753 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 800
Query: 500 GWFKGASLRTGVSGVFPGNYV 520
GWF G S RT G FPGNYV
Sbjct: 801 GWFVGTSRRTKFFGTFPGNYV 821
Score = 89.7 bits (221), Expect = 1e-17
Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%)
Query: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183
R R + P PP R + QSA+ T G PGS L+ + S++ S A
Sbjct: 505 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 558
Query: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225
R +P + + L G KA+Y ++ + +L F KGD + + R
Sbjct: 559 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 618
Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272
K+D+ WY GE HG G P SY++ + P A P + A Y+F
Sbjct: 619 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 678
Query: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328
+ L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D
Sbjct: 679 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 734
Query: 329 PCPAAASS 336
P P + SS
Sbjct: 735 PIPHSYSS 742
Score = 54.7 bits (130), Expect = 4e-07
Identities = 22/55 (40%), Positives = 39/55 (70%)
Query: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+
Sbjct: 768 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822
Score = 52.8 bits (125), Expect = 1e-06
Identities = 62/276 (22%), Positives = 101/276 (36%), Gaps = 41/276 (14%)
Query: 613 SAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAA 672
S Q + P +P P R P +S R V S PP PR P S+
Sbjct: 400 SILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTG---SPSPP----PRSGAPTPSSR 452
Query: 673 SAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGAST 732
+ P GV + +S + ++ E+ + + +
Sbjct: 453 APALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSI---DRSLERPMSSASM-----ASDF 504
Query: 733 KKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRA----GSCPIESEMQGAMGM 788
+K+ +S P+V P +G + +S + GR S + +
Sbjct: 505 RKRRKSEPAVGPPR------------GLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPS 552
Query: 789 EPLHRK----AGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIEL 844
P K S T R AP PE + LP + V + Q+ E+
Sbjct: 553 SPSRAKDRESPRSYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSF 608
Query: 845 KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
K+GD V++ +K + WY+G + +GR G+FP S+VE
Sbjct: 609 KKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVE 642
Score = 51.2 bits (121), Expect = 4e-06
Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%)
Query: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469
+SS P + +R D ++ S ST T + R+A +GTP K +LP
Sbjct: 547 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 593
Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526
A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP +
Sbjct: 594 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 650
Query: 527 PAGGAGPPRNNVVGGSPLAK 546
PP G +AK
Sbjct: 651 QPARPPPPAQPGEIGEAIAK 670
Score = 48.5 bits (114), Expect = 3e-05
Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838
E E G +G+ P+ S T P + P RP P P E + Y +
Sbjct: 626 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 675
Query: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
+ +EL ++GD V + K+ + WY+G + R G+FP S+VE
Sbjct: 676 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 719
Score = 39.7 bits (91), Expect = 0.012
Identities = 21/76 (27%), Positives = 34/76 (44%)
Query: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518
PP + +A Y + + EL L KG+ +L++ W++G T G+FP +
Sbjct: 657 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 716
Query: 519 YVTPVSRVPAGGAGPP 534
YV V + G P
Sbjct: 717 YVEVVKKNTKGAEDYP 732
Score = 34.3 bits (77), Expect = 0.52
Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
+ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++
Sbjct: 771 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 90.9 bits (224), Expect = 5e-18
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%)
Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321
KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE
Sbjct: 430 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 479
Query: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381
+L +K PA P+ G + ++ V R+ D K+
Sbjct: 480 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 534
Query: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439
+ ++R + + V + + + A D + H + +SS+
Sbjct: 535 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 589
Query: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499
P GE + ALY Y P+ DELEL + ++ V+EKC D
Sbjct: 590 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 637
Query: 500 GWFKGASLRTGVSGVFPGNYV 520
GWF G S RT G FPGNYV
Sbjct: 638 GWFVGTSRRTKFFGTFPGNYV 658
Score = 89.7 bits (221), Expect = 1e-17
Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%)
Query: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183
R R + P PP R + QSA+ T G PGS L+ + S++ S A
Sbjct: 342 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 395
Query: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225
R +P + + L G KA+Y ++ + +L F KGD + + R
Sbjct: 396 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 455
Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272
K+D+ WY GE HG G P SY++ + P A P + A Y+F
Sbjct: 456 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 515
Query: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328
+ L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D
Sbjct: 516 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 571
Query: 329 PCPAAASS 336
P P + SS
Sbjct: 572 PIPHSYSS 579
Score = 54.7 bits (130), Expect = 4e-07
Identities = 22/55 (40%), Positives = 39/55 (70%)
Query: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+
Sbjct: 605 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 659
Score = 51.2 bits (121), Expect = 4e-06
Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%)
Query: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469
+SS P + +R D ++ S ST T + R+A +GTP K +LP
Sbjct: 384 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 430
Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526
A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP +
Sbjct: 431 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 487
Query: 527 PAGGAGPPRNNVVGGSPLAK 546
PP G +AK
Sbjct: 488 QPARPPPPAQPGEIGEAIAK 507
Score = 49.3 bits (116), Expect = 2e-05
Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 6/84 (7%)
Query: 797 SLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR 856
S T R AP PE + LP + V + Q+ E+ K+GD V++ +K
Sbjct: 402 SYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSFKKGDTVYILRKI 457
Query: 857 EDGWYKGTLQRNGRTGLFPGSFVE 880
+ WY+G + +GR G+FP S+VE
Sbjct: 458 DQNWYEG--EHHGRVGIFPISYVE 479
Score = 48.5 bits (114), Expect = 3e-05
Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838
E E G +G+ P+ S T P + P RP P P E + Y +
Sbjct: 463 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 512
Query: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
+ +EL ++GD V + K+ + WY+G + R G+FP S+VE
Sbjct: 513 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 556
Score = 39.7 bits (91), Expect = 0.012
Identities = 21/76 (27%), Positives = 34/76 (44%)
Query: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518
PP + +A Y + + EL L KG+ +L++ W++G T G+FP +
Sbjct: 494 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 553
Query: 519 YVTPVSRVPAGGAGPP 534
YV V + G P
Sbjct: 554 YVEVVKKNTKGAEDYP 569
Score = 34.3 bits (77), Expect = 0.52
Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
+ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++
Sbjct: 608 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 659
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 90.9 bits (224), Expect = 5e-18
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%)
Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321
KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE
Sbjct: 500 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 549
Query: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381
+L +K PA P+ G + ++ V R+ D K+
Sbjct: 550 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 604
Query: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439
+ ++R + + V + + + A D + H + +SS+
Sbjct: 605 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 659
Query: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499
P GE + ALY Y P+ DELEL + ++ V+EKC D
Sbjct: 660 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 707
Query: 500 GWFKGASLRTGVSGVFPGNYV 520
GWF G S RT G FPGNYV
Sbjct: 708 GWFVGTSRRTKFFGTFPGNYV 728
Score = 89.7 bits (221), Expect = 1e-17
Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%)
Query: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183
R R + P PP R + QSA+ T G PGS L+ + S++ S A
Sbjct: 412 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 465
Query: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225
R +P + + L G KA+Y ++ + +L F KGD + + R
Sbjct: 466 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 525
Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272
K+D+ WY GE HG G P SY++ + P A P + A Y+F
Sbjct: 526 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 585
Query: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328
+ L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D
Sbjct: 586 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 641
Query: 329 PCPAAASS 336
P P + SS
Sbjct: 642 PIPHSYSS 649
Score = 54.7 bits (130), Expect = 4e-07
Identities = 22/55 (40%), Positives = 39/55 (70%)
Query: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+
Sbjct: 675 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729
Score = 52.8 bits (125), Expect = 1e-06
Identities = 62/276 (22%), Positives = 101/276 (36%), Gaps = 41/276 (14%)
Query: 613 SAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAA 672
S Q + P +P P R P +S R V S PP PR P S+
Sbjct: 307 SILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTG---SPSPP----PRSGAPTPSSR 359
Query: 673 SAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGAST 732
+ P GV + +S + ++ E+ + + +
Sbjct: 360 APALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSI---DRSLERPMSSASM-----ASDF 411
Query: 733 KKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRA----GSCPIESEMQGAMGM 788
+K+ +S P+V P +G + +S + GR S + +
Sbjct: 412 RKRRKSEPAVGPPR------------GLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPS 459
Query: 789 EPLHRK----AGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIEL 844
P K S T R AP PE + LP + V + Q+ E+
Sbjct: 460 SPSRAKDRESPRSYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSF 515
Query: 845 KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
K+GD V++ +K + WY+G + +GR G+FP S+VE
Sbjct: 516 KKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVE 549
Score = 51.2 bits (121), Expect = 4e-06
Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%)
Query: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469
+SS P + +R D ++ S ST T + R+A +GTP K +LP
Sbjct: 454 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 500
Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526
A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP +
Sbjct: 501 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 557
Query: 527 PAGGAGPPRNNVVGGSPLAK 546
PP G +AK
Sbjct: 558 QPARPPPPAQPGEIGEAIAK 577
Score = 48.5 bits (114), Expect = 3e-05
Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838
E E G +G+ P+ S T P + P RP P P E + Y +
Sbjct: 533 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 582
Query: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
+ +EL ++GD V + K+ + WY+G + R G+FP S+VE
Sbjct: 583 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 626
Score = 39.7 bits (91), Expect = 0.012
Identities = 21/76 (27%), Positives = 34/76 (44%)
Query: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518
PP + +A Y + + EL L KG+ +L++ W++G T G+FP +
Sbjct: 564 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 623
Query: 519 YVTPVSRVPAGGAGPP 534
YV V + G P
Sbjct: 624 YVEVVKKNTKGAEDYP 639
Score = 34.3 bits (77), Expect = 0.52
Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
+ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++
Sbjct: 678 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 90.9 bits (224), Expect = 5e-18
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%)
Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321
KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE
Sbjct: 413 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 462
Query: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381
+L +K PA P+ G + ++ V R+ D K+
Sbjct: 463 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 517
Query: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439
+ ++R + + V + + + A D + H + +SS+
Sbjct: 518 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 572
Query: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499
P GE + ALY Y P+ DELEL + ++ V+EKC D
Sbjct: 573 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 620
Query: 500 GWFKGASLRTGVSGVFPGNYV 520
GWF G S RT G FPGNYV
Sbjct: 621 GWFVGTSRRTKFFGTFPGNYV 641
Score = 89.7 bits (221), Expect = 1e-17
Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%)
Query: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183
R R + P PP R + QSA+ T G PGS L+ + S++ S A
Sbjct: 325 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 378
Query: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225
R +P + + L G KA+Y ++ + +L F KGD + + R
Sbjct: 379 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 438
Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272
K+D+ WY GE HG G P SY++ + P A P + A Y+F
Sbjct: 439 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 498
Query: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328
+ L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D
Sbjct: 499 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 554
Query: 329 PCPAAASS 336
P P + SS
Sbjct: 555 PIPHSYSS 562
Score = 54.7 bits (130), Expect = 4e-07
Identities = 22/55 (40%), Positives = 39/55 (70%)
Query: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+
Sbjct: 588 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
Score = 51.2 bits (121), Expect = 4e-06
Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%)
Query: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469
+SS P + +R D ++ S ST T + R+A +GTP K +LP
Sbjct: 367 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 413
Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526
A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP +
Sbjct: 414 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 470
Query: 527 PAGGAGPPRNNVVGGSPLAK 546
PP G +AK
Sbjct: 471 QPARPPPPAQPGEIGEAIAK 490
Score = 50.8 bits (120), Expect = 5e-06
Identities = 67/290 (23%), Positives = 109/290 (37%), Gaps = 49/290 (16%)
Query: 608 STAAHSAAQAQD-RPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAI 666
S +H AA+ Q RP +S + NSP+ S S V P H P + PR
Sbjct: 205 SAQSHPAAKTQTYRP---LSKSHSDNSPNAFKDAS----SPVPPPHVPPPVPPLRPRDRS 257
Query: 667 PLTSAASAITPPN--VSAANLNGEAGG------GPIGVLSTSSPTNTGCKLDEKKSEKKE 718
++ PP+ V E G +L P + ++ E+
Sbjct: 258 --STEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPM 315
Query: 719 KKSGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRA----G 774
+ + + +K+ +S P+V P +G + +S + GR
Sbjct: 316 SSASM-----ASDFRKRRKSEPAVGPPR------------GLGDQSASRTSPGRVDLPGS 358
Query: 775 SCPIESEMQGAMGMEPLHRK----AGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRV 830
S + + P K S T R AP PE + LP +
Sbjct: 359 STTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT-PEKEKLPA---KA 414
Query: 831 VVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
V + Q+ E+ K+GD V++ +K + WY+G + +GR G+FP S+VE
Sbjct: 415 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVE 462
Score = 48.5 bits (114), Expect = 3e-05
Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838
E E G +G+ P+ S T P + P RP P P E + Y +
Sbjct: 446 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 495
Query: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
+ +EL ++GD V + K+ + WY+G + R G+FP S+VE
Sbjct: 496 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 539
Score = 39.7 bits (91), Expect = 0.012
Identities = 21/76 (27%), Positives = 34/76 (44%)
Query: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518
PP + +A Y + + EL L KG+ +L++ W++G T G+FP +
Sbjct: 477 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 536
Query: 519 YVTPVSRVPAGGAGPP 534
YV V + G P
Sbjct: 537 YVEVVKKNTKGAEDYP 552
Score = 34.3 bits (77), Expect = 0.52
Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
+ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++
Sbjct: 591 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 90.9 bits (224), Expect = 5e-18
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%)
Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321
KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE
Sbjct: 869 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 918
Query: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381
+L +K PA P+ G + ++ V R+ D K+
Sbjct: 919 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 973
Query: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439
+ ++R + + V + + + A D + H + +SS+
Sbjct: 974 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 1028
Query: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499
P GE + ALY Y P+ DELEL + ++ V+EKC D
Sbjct: 1029 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 1076
Query: 500 GWFKGASLRTGVSGVFPGNYV 520
GWF G S RT G FPGNYV
Sbjct: 1077 GWFVGTSRRTKFFGTFPGNYV 1097
Score = 81.6 bits (200), Expect = 3e-15
Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 21/154 (13%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
KA+Y ++ + +L F KGD + + RK+D+ WY GE HG G P SY++ + P A P
Sbjct: 869 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 928
Query: 260 -------------QGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GD 304
+ A Y+F + L+ K + + +L+RVD+NW EG + +
Sbjct: 929 ARPPPPAQPGEIGEAIAKYNFNADTNVE----LSLRKGDRVILLKRVDQNWYEGKIPGTN 984
Query: 305 KIGIFPLLYVELNDSAKQLIE--MDKPCPAAASS 336
+ GIFP+ YVE+ + E D P P + SS
Sbjct: 985 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSS 1018
Score = 54.7 bits (130), Expect = 4e-07
Identities = 22/55 (40%), Positives = 39/55 (70%)
Query: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+
Sbjct: 1044 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
Score = 53.5 bits (127), Expect = 8e-07
Identities = 42/179 (23%), Positives = 74/179 (41%), Gaps = 47/179 (26%)
Query: 180 ELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGT 239
E A P P + A Y++ +L KGD ++L ++VD+ WY G++ GT
Sbjct: 924 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 983
Query: 240 --QGFLPASYIQCIQ------------PLPHA------------PPQG------------ 261
QG P SY++ ++ P+PH+ PQ
Sbjct: 984 NRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 1043
Query: 262 ---KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDK--IGIFPLLYVE 315
+ALY++ +++D+ L + +++ V+ + D+ W G G FP YV+
Sbjct: 1044 EPFQALYNYTPRNEDE----LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
Score = 52.0 bits (123), Expect = 2e-06
Identities = 46/144 (31%), Positives = 66/144 (45%), Gaps = 17/144 (11%)
Query: 414 PRAAA-RIGDLAHLSC-------AAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLP 465
PR+A+ + D A+ SC A ++ S ST T + R+A +GTP K +LP
Sbjct: 809 PRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLP 867
Query: 466 LNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TP 522
A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP
Sbjct: 868 AK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTP 922
Query: 523 VSRVPAGGAGPPRNNVVGGSPLAK 546
+ PP G +AK
Sbjct: 923 PEKAQPARPPPPAQPGEIGEAIAK 946
Score = 49.3 bits (116), Expect = 2e-05
Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 6/84 (7%)
Query: 797 SLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR 856
S T R AP PE + LP + V + Q+ E+ K+GD V++ +K
Sbjct: 841 SYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSFKKGDTVYILRKI 896
Query: 857 EDGWYKGTLQRNGRTGLFPGSFVE 880
+ WY+G + +GR G+FP S+VE
Sbjct: 897 DQNWYEG--EHHGRVGIFPISYVE 918
Score = 48.5 bits (114), Expect = 3e-05
Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838
E E G +G+ P+ S T P + P RP P P E + Y +
Sbjct: 902 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 951
Query: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
+ +EL ++GD V + K+ + WY+G + R G+FP S+VE
Sbjct: 952 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 995
Score = 39.7 bits (91), Expect = 0.012
Identities = 21/76 (27%), Positives = 34/76 (44%)
Query: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518
PP + +A Y + + EL L KG+ +L++ W++G T G+FP +
Sbjct: 933 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 992
Query: 519 YVTPVSRVPAGGAGPP 534
YV V + G P
Sbjct: 993 YVEVVKKNTKGAEDYP 1008
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 90.9 bits (224), Expect = 5e-18
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%)
Query: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321
KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE
Sbjct: 435 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 484
Query: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381
+L +K PA P+ G + ++ V R+ D K+
Sbjct: 485 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 539
Query: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439
+ ++R + + V + + + A D + H + +SS+
Sbjct: 540 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 594
Query: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499
P GE + ALY Y P+ DELEL + ++ V+EKC D
Sbjct: 595 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 642
Query: 500 GWFKGASLRTGVSGVFPGNYV 520
GWF G S RT G FPGNYV
Sbjct: 643 GWFVGTSRRTKFFGTFPGNYV 663
Score = 89.7 bits (221), Expect = 1e-17
Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%)
Query: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183
R R + P PP R + QSA+ T G PGS L+ + S++ S A
Sbjct: 347 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 400
Query: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225
R +P + + L G KA+Y ++ + +L F KGD + + R
Sbjct: 401 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 460
Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272
K+D+ WY GE HG G P SY++ + P A P + A Y+F
Sbjct: 461 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 520
Query: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328
+ L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D
Sbjct: 521 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 576
Query: 329 PCPAAASS 336
P P + SS
Sbjct: 577 PIPHSYSS 584
Score = 54.7 bits (130), Expect = 4e-07
Identities = 22/55 (40%), Positives = 39/55 (70%)
Query: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+
Sbjct: 610 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 664
Score = 51.2 bits (121), Expect = 4e-06
Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%)
Query: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469
+SS P + +R D ++ S ST T + R+A +GTP K +LP
Sbjct: 389 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 435
Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526
A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP +
Sbjct: 436 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 492
Query: 527 PAGGAGPPRNNVVGGSPLAK 546
PP G +AK
Sbjct: 493 QPARPPPPAQPGEIGEAIAK 512
Score = 49.3 bits (116), Expect = 2e-05
Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 6/84 (7%)
Query: 797 SLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR 856
S T R AP PE + LP + V + Q+ E+ K+GD V++ +K
Sbjct: 407 SYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSFKKGDTVYILRKI 462
Query: 857 EDGWYKGTLQRNGRTGLFPGSFVE 880
+ WY+G + +GR G+FP S+VE
Sbjct: 463 DQNWYEG--EHHGRVGIFPISYVE 484
Score = 48.5 bits (114), Expect = 3e-05
Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838
E E G +G+ P+ S T P + P RP P P E + Y +
Sbjct: 468 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 517
Query: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
+ +EL ++GD V + K+ + WY+G + R G+FP S+VE
Sbjct: 518 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 561
Score = 39.7 bits (91), Expect = 0.012
Identities = 21/76 (27%), Positives = 34/76 (44%)
Query: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518
PP + +A Y + + EL L KG+ +L++ W++G T G+FP +
Sbjct: 499 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 558
Query: 519 YVTPVSRVPAGGAGPP 534
YV V + G P
Sbjct: 559 YVEVVKKNTKGAEDYP 574
Score = 34.3 bits (77), Expect = 0.52
Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
+ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++
Sbjct: 613 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 664
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 88.2 bits (217), Expect = 3e-17
Identities = 83/341 (24%), Positives = 132/341 (38%), Gaps = 71/341 (20%)
Query: 197 PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLP- 255
P+ L+ + ++ DL G+I+ L K+D WY G G PA+Y++ I +P
Sbjct: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 498
Query: 256 -----------HAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGD 304
H + + FE + KD L+F++ EI+ + V+E WA G +
Sbjct: 499 GGNGKRECVSSHCVKGSRCVARFEY--IGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 556
Query: 305 KIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLP-----SDSGAVASVAPSPTLSS 359
+ GIFPL +VE + D P + A+ + +P DSG+ + V P
Sbjct: 557 RTGIFPLNFVEPVE--------DYP-TSGANVLSTKVPLKTKKEDSGSNSQVNSLPA--- 604
Query: 360 SGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAAR 419
+ + HSFTA +S S + I +L R
Sbjct: 605 --------------EWCEALHSFTA-----ETSDDLSFKRGDRIQ--ILERLDSDWCRGR 643
Query: 420 IGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQK 479
+ D + A + + A S VP+ ALY ++ +
Sbjct: 644 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAK-----------------ALYDFRGEN 686
Query: 480 SDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
DEL G++ LE D W G + G SG+FP NY+
Sbjct: 687 EDELSFKAGDIITELESVDDDWMSGELM--GKSGIFPKNYI 725
Score = 73.2 bits (178), Expect = 1e-12
Identities = 43/126 (34%), Positives = 67/126 (53%), Gaps = 17/126 (13%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAP- 258
+AL+S+ + DL F +GD I + ++D W G L +G PA + ++P P
Sbjct: 608 EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVF---VRPCPAEAK 664
Query: 259 ------PQG---KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIF 309
P+G KALYDF +++D+ L+F +I+T L VD++W G L K GIF
Sbjct: 665 SMLAIVPKGRKAKALYDFRGENEDE----LSFKAGDIITELESVDDDWMSGELMGKSGIF 720
Query: 310 PLLYVE 315
P Y++
Sbjct: 721 PKNYIQ 726
Score = 57.0 bits (136), Expect = 8e-08
Identities = 92/436 (21%), Positives = 154/436 (35%), Gaps = 86/436 (19%)
Query: 115 VRLLDGIRQRPRAG-TSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGS 173
VR+ + RP G T P PP + P + P L+ S P S++
Sbjct: 281 VRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSA----TRRSNKKLPFNRSSSDMD 336
Query: 174 TAGSLRELATSRTAPAAK-----NPCLLPY---GKALYSYEGKEPGDLKFNKGDIIVLRR 225
LAT + ++ +P L P G LYS K+ +GD++V+ +
Sbjct: 337 LQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYS---------KYMRGDVLVMLK 387
Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPL-------PHAP-----------PQGKALYDF 267
+ + + + G + S ++ I PL P+ P P L+DF
Sbjct: 388 QTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDF 447
Query: 268 EMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMD 327
+ D L T EI+ +L ++D +W G ++IGIFP YV K +I+
Sbjct: 448 PAEQVDD----LNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYV------KVIID-- 495
Query: 328 KPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSV 387
+P S + S V+ F+ + K +
Sbjct: 496 -------------IPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILK 542
Query: 388 THRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDV-SSSAGSTPTAV 446
+ + + A R G + L+ P +D +S A T V
Sbjct: 543 EYVNEEWARGE-----------------VRGRTG-IFPLNFVEPVEDYPTSGANVLSTKV 584
Query: 447 PRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGAS 506
P LP AL+++ + SD+L +G+ ++LE+ W +G
Sbjct: 585 PLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGR- 643
Query: 507 LRTGVSGVFPGNYVTP 522
G+FP +V P
Sbjct: 644 -LQDREGIFPAVFVRP 658
Score = 53.9 bits (128), Expect = 6e-07
Identities = 28/69 (40%), Positives = 36/69 (52%), Gaps = 3/69 (4%)
Query: 187 APAAKNPCLLPYG---KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFL 243
A A ++P G KALY + G+ +L F GDII VD+ W GEL G G
Sbjct: 661 AEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIF 720
Query: 244 PASYIQCIQ 252
P +YIQ +Q
Sbjct: 721 PKNYIQFLQ 729
Score = 45.4 bits (106), Expect = 2e-04
Identities = 22/63 (34%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529
+ L+ + ++ D+L L GE+ +LEK W++G + R + G+FP NYV + +P G
Sbjct: 442 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG-NCRNQI-GIFPANYVKVIIDIPEG 499
Query: 530 GAG 532
G G
Sbjct: 500 GNG 502
Score = 40.4 bits (93), Expect = 0.007
Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 2/62 (3%)
Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529
+A + Y ++ DEL +GE+ + E + W +G G +G+FP N+V PV P
Sbjct: 518 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFVEPVEDYPTS 575
Query: 530 GA 531
GA
Sbjct: 576 GA 577
Score = 38.9 bits (89), Expect = 0.021
Identities = 23/90 (25%), Positives = 43/90 (47%), Gaps = 7/90 (7%)
Query: 791 LHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIV 850
L + G F P SM AI P+ + + + + + ++E E+ K GDI+
Sbjct: 644 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGR-----KAKALYDFRGENEDELSFKAGDII 698
Query: 851 FVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
+ +D W G L G++G+FP ++++
Sbjct: 699 TELESVDDDWMSGELM--GKSGIFPKNYIQ 726
Score = 37.0 bits (84), Expect = 0.081
Identities = 25/102 (24%), Positives = 41/102 (40%), Gaps = 18/102 (17%)
Query: 794 KAGSLDLNFTSPSRQAPLSMAAI----------------RPEPKLLPRERYRVVVSYPPQ 837
+ G LNF P P S A + + LP E + S+ +
Sbjct: 557 RTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAE 616
Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFV 879
+ ++ K GD + + ++ + W +G LQ R G+FP FV
Sbjct: 617 TSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFV 656
Score = 35.4 bits (80), Expect = 0.23
Identities = 16/47 (34%), Positives = 29/47 (61%), Gaps = 2/47 (4%)
Query: 834 YPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Y + + E+ EG+I+ + + + W +G ++ GRTG+FP +FVE
Sbjct: 523 YIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVE 567
Score = 35.0 bits (79), Expect = 0.31
Identities = 14/51 (27%), Positives = 31/51 (60%), Gaps = 2/51 (3%)
Query: 830 VVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
V+ +P + ++ L G+IV++ +K + WY+G + + G+FP ++V+
Sbjct: 443 VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQIGIFPANYVK 491
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 88.2 bits (217), Expect = 3e-17
Identities = 83/341 (24%), Positives = 132/341 (38%), Gaps = 71/341 (20%)
Query: 197 PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLP- 255
P+ L+ + ++ DL G+I+ L K+D WY G G PA+Y++ I +P
Sbjct: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 534
Query: 256 -----------HAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGD 304
H + + FE + KD L+F++ EI+ + V+E WA G +
Sbjct: 535 GGNGKRECVSSHCVKGSRCVARFEY--IGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 592
Query: 305 KIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLP-----SDSGAVASVAPSPTLSS 359
+ GIFPL +VE + D P + A+ + +P DSG+ + V P
Sbjct: 593 RTGIFPLNFVEPVE--------DYP-TSGANVLSTKVPLKTKKEDSGSNSQVNSLPA--- 640
Query: 360 SGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAAR 419
+ + HSFTA +S S + I +L R
Sbjct: 641 --------------EWCEALHSFTA-----ETSDDLSFKRGDRIQ--ILERLDSDWCRGR 679
Query: 420 IGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQK 479
+ D + A + + A S VP+ ALY ++ +
Sbjct: 680 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAK-----------------ALYDFRGEN 722
Query: 480 SDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
DEL G++ LE D W G + G SG+FP NY+
Sbjct: 723 EDELSFKAGDIITELESVDDDWMSGELM--GKSGIFPKNYI 761
Score = 73.2 bits (178), Expect = 1e-12
Identities = 43/126 (34%), Positives = 67/126 (53%), Gaps = 17/126 (13%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAP- 258
+AL+S+ + DL F +GD I + ++D W G L +G PA + ++P P
Sbjct: 644 EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVF---VRPCPAEAK 700
Query: 259 ------PQG---KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIF 309
P+G KALYDF +++D+ L+F +I+T L VD++W G L K GIF
Sbjct: 701 SMLAIVPKGRKAKALYDFRGENEDE----LSFKAGDIITELESVDDDWMSGELMGKSGIF 756
Query: 310 PLLYVE 315
P Y++
Sbjct: 757 PKNYIQ 762
Score = 57.0 bits (136), Expect = 8e-08
Identities = 92/436 (21%), Positives = 154/436 (35%), Gaps = 86/436 (19%)
Query: 115 VRLLDGIRQRPRAG-TSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGS 173
VR+ + RP G T P PP + P + P L+ S P S++
Sbjct: 317 VRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSA----TRRSNKKLPFNRSSSDMD 372
Query: 174 TAGSLRELATSRTAPAAK-----NPCLLPY---GKALYSYEGKEPGDLKFNKGDIIVLRR 225
LAT + ++ +P L P G LYS K+ +GD++V+ +
Sbjct: 373 LQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYS---------KYMRGDVLVMLK 423
Query: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPL-------PHAP-----------PQGKALYDF 267
+ + + + G + S ++ I PL P+ P P L+DF
Sbjct: 424 QTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDF 483
Query: 268 EMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMD 327
+ D L T EI+ +L ++D +W G ++IGIFP YV K +I+
Sbjct: 484 PAEQVDD----LNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYV------KVIID-- 531
Query: 328 KPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSV 387
+P S + S V+ F+ + K +
Sbjct: 532 -------------IPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILK 578
Query: 388 THRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDV-SSSAGSTPTAV 446
+ + + A R G + L+ P +D +S A T V
Sbjct: 579 EYVNEEWARGE-----------------VRGRTG-IFPLNFVEPVEDYPTSGANVLSTKV 620
Query: 447 PRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGAS 506
P LP AL+++ + SD+L +G+ ++LE+ W +G
Sbjct: 621 PLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGR- 679
Query: 507 LRTGVSGVFPGNYVTP 522
G+FP +V P
Sbjct: 680 -LQDREGIFPAVFVRP 694
Score = 53.9 bits (128), Expect = 6e-07
Identities = 28/69 (40%), Positives = 36/69 (52%), Gaps = 3/69 (4%)
Query: 187 APAAKNPCLLPYG---KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFL 243
A A ++P G KALY + G+ +L F GDII VD+ W GEL G G
Sbjct: 697 AEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIF 756
Query: 244 PASYIQCIQ 252
P +YIQ +Q
Sbjct: 757 PKNYIQFLQ 765
Score = 45.4 bits (106), Expect = 2e-04
Identities = 22/63 (34%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529
+ L+ + ++ D+L L GE+ +LEK W++G + R + G+FP NYV + +P G
Sbjct: 478 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG-NCRNQI-GIFPANYVKVIIDIPEG 535
Query: 530 GAG 532
G G
Sbjct: 536 GNG 538
Score = 40.4 bits (93), Expect = 0.007
Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 2/62 (3%)
Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529
+A + Y ++ DEL +GE+ + E + W +G G +G+FP N+V PV P
Sbjct: 554 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFVEPVEDYPTS 611
Query: 530 GA 531
GA
Sbjct: 612 GA 613
Score = 38.9 bits (89), Expect = 0.021
Identities = 23/90 (25%), Positives = 43/90 (47%), Gaps = 7/90 (7%)
Query: 791 LHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIV 850
L + G F P SM AI P+ + + + + + ++E E+ K GDI+
Sbjct: 680 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGR-----KAKALYDFRGENEDELSFKAGDII 734
Query: 851 FVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
+ +D W G L G++G+FP ++++
Sbjct: 735 TELESVDDDWMSGELM--GKSGIFPKNYIQ 762
Score = 37.0 bits (84), Expect = 0.081
Identities = 25/102 (24%), Positives = 41/102 (40%), Gaps = 18/102 (17%)
Query: 794 KAGSLDLNFTSPSRQAPLSMAAI----------------RPEPKLLPRERYRVVVSYPPQ 837
+ G LNF P P S A + + LP E + S+ +
Sbjct: 593 RTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAE 652
Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFV 879
+ ++ K GD + + ++ + W +G LQ R G+FP FV
Sbjct: 653 TSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFV 692
Score = 35.4 bits (80), Expect = 0.23
Identities = 16/47 (34%), Positives = 29/47 (61%), Gaps = 2/47 (4%)
Query: 834 YPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Y + + E+ EG+I+ + + + W +G ++ GRTG+FP +FVE
Sbjct: 559 YIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVE 603
Score = 35.0 bits (79), Expect = 0.31
Identities = 14/51 (27%), Positives = 31/51 (60%), Gaps = 2/51 (3%)
Query: 830 VVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
V+ +P + ++ L G+IV++ +K + WY+G + + G+FP ++V+
Sbjct: 479 VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQIGIFPANYVK 527
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 88.2 bits (217), Expect = 3e-17
Identities = 83/341 (24%), Positives = 132/341 (38%), Gaps = 71/341 (20%)
Query: 197 PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLP- 255
P+ L+ + ++ DL G+I+ L K+D WY G G PA+Y++ I +P
Sbjct: 498 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 557
Query: 256 -----------HAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGD 304
H + + FE + KD L+F++ EI+ + V+E WA G +
Sbjct: 558 GGNGKRECVSSHCVKGSRCVARFEY--IGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 615
Query: 305 KIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLP-----SDSGAVASVAPSPTLSS 359
+ GIFPL +VE + D P + A+ + +P DSG+ + V P
Sbjct: 616 RTGIFPLNFVEPVE--------DYP-TSGANVLSTKVPLKTKKEDSGSNSQVNSLPA--- 663
Query: 360 SGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAAR 419
+ + HSFTA +S S + I +L R
Sbjct: 664 --------------EWCEALHSFTA-----ETSDDLSFKRGDRIQ--ILERLDSDWCRGR 702
Query: 420 IGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQK 479
+ D + A + + A S VP+ ALY ++ +
Sbjct: 703 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAK-----------------ALYDFRGEN 745
Query: 480 SDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
DEL G++ LE D W G + G SG+FP NY+
Sbjct: 746 EDELSFKAGDIITELESVDDDWMSGELM--GKSGIFPKNYI 784
Score = 73.2 bits (178), Expect = 1e-12
Identities = 43/126 (34%), Positives = 67/126 (53%), Gaps = 17/126 (13%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAP- 258
+AL+S+ + DL F +GD I + ++D W G L +G PA + ++P P
Sbjct: 667 EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVF---VRPCPAEAK 723
Query: 259 ------PQG---KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIF 309
P+G KALYDF +++D+ L+F +I+T L VD++W G L K GIF
Sbjct: 724 SMLAIVPKGRKAKALYDFRGENEDE----LSFKAGDIITELESVDDDWMSGELMGKSGIF 779
Query: 310 PLLYVE 315
P Y++
Sbjct: 780 PKNYIQ 785
Score = 63.5 bits (153), Expect = 8e-10
Identities = 72/346 (20%), Positives = 126/346 (36%), Gaps = 64/346 (18%)
Query: 196 LPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPL- 254
+P+G A + PG+L +GD++V+ ++ + + + G + S ++ I PL
Sbjct: 417 VPHGIANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLD 476
Query: 255 ------PHAP-----------PQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENW 297
P+ P P L+DF + D L T EI+ +L ++D +W
Sbjct: 477 EHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDD----LNLTSGEIVYLLEKIDTDW 532
Query: 298 AEGMLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTL 357
G ++IGIFP YV K +I+ +P S +
Sbjct: 533 YRGNCRNQIGIFPANYV------KVIID---------------IPEGGNGKRECVSSHCV 571
Query: 358 SSSGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAA 417
S V+ F+ + K + + + + A
Sbjct: 572 KGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGE-----------------VR 614
Query: 418 ARIGDLAHLSCAAPTQDV-SSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYK 476
R G + L+ P +D +S A T VP LP AL+++
Sbjct: 615 GRTG-IFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFT 673
Query: 477 PQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTP 522
+ SD+L +G+ ++LE+ W +G G+FP +V P
Sbjct: 674 AETSDDLSFKRGDRIQILERLDSDWCRGR--LQDREGIFPAVFVRP 717
Score = 53.9 bits (128), Expect = 6e-07
Identities = 28/69 (40%), Positives = 36/69 (52%), Gaps = 3/69 (4%)
Query: 187 APAAKNPCLLPYG---KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFL 243
A A ++P G KALY + G+ +L F GDII VD+ W GEL G G
Sbjct: 720 AEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIF 779
Query: 244 PASYIQCIQ 252
P +YIQ +Q
Sbjct: 780 PKNYIQFLQ 788
Score = 45.4 bits (106), Expect = 2e-04
Identities = 22/63 (34%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529
+ L+ + ++ D+L L GE+ +LEK W++G + R + G+FP NYV + +P G
Sbjct: 501 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG-NCRNQI-GIFPANYVKVIIDIPEG 558
Query: 530 GAG 532
G G
Sbjct: 559 GNG 561
Score = 40.4 bits (93), Expect = 0.007
Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 2/62 (3%)
Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529
+A + Y ++ DEL +GE+ + E + W +G G +G+FP N+V PV P
Sbjct: 577 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFVEPVEDYPTS 634
Query: 530 GA 531
GA
Sbjct: 635 GA 636
Score = 38.9 bits (89), Expect = 0.021
Identities = 23/90 (25%), Positives = 43/90 (47%), Gaps = 7/90 (7%)
Query: 791 LHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIV 850
L + G F P SM AI P+ + + + + + ++E E+ K GDI+
Sbjct: 703 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGR-----KAKALYDFRGENEDELSFKAGDII 757
Query: 851 FVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
+ +D W G L G++G+FP ++++
Sbjct: 758 TELESVDDDWMSGELM--GKSGIFPKNYIQ 785
Score = 37.0 bits (84), Expect = 0.081
Identities = 25/102 (24%), Positives = 41/102 (40%), Gaps = 18/102 (17%)
Query: 794 KAGSLDLNFTSPSRQAPLSMAAI----------------RPEPKLLPRERYRVVVSYPPQ 837
+ G LNF P P S A + + LP E + S+ +
Sbjct: 616 RTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAE 675
Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFV 879
+ ++ K GD + + ++ + W +G LQ R G+FP FV
Sbjct: 676 TSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFV 715
Score = 35.4 bits (80), Expect = 0.23
Identities = 16/47 (34%), Positives = 29/47 (61%), Gaps = 2/47 (4%)
Query: 834 YPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Y + + E+ EG+I+ + + + W +G ++ GRTG+FP +FVE
Sbjct: 582 YIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVE 626
Score = 35.0 bits (79), Expect = 0.31
Identities = 14/51 (27%), Positives = 31/51 (60%), Gaps = 2/51 (3%)
Query: 830 VVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
V+ +P + ++ L G+IV++ +K + WY+G + + G+FP ++V+
Sbjct: 502 VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQIGIFPANYVK 550
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 87.8 bits (216), Expect = 4e-17
Identities = 52/172 (30%), Positives = 89/172 (51%), Gaps = 17/172 (9%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
+A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P
Sbjct: 799 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 858
Query: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307
+ G+A+ F Q + ++F K E +T+LR+VDENW EG + + G
Sbjct: 859 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 916
Query: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAASSCNASLPSDSGAVASVAPSPT 356
IFP+ YV++ K ++ MD P ++ S + P S + P+P+
Sbjct: 917 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLITPAPS 968
Score = 82.4 bits (202), Expect = 2e-15
Identities = 111/486 (22%), Positives = 184/486 (37%), Gaps = 98/486 (20%)
Query: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505
+P A ++ TP +V L +A + + E+ KGE +L + + W++G
Sbjct: 850 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 908
Query: 506 SLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMH-PGSGSLSSLAT 564
T G+FP YV + R PL K M P S S S AT
Sbjct: 909 IPGTSRQGIFPITYVDVIKR-----------------PLVKNPVDYMDLPFSSSPSRSAT 951
Query: 565 ATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTAT 624
A+ PQ + H P S L HS + + + + S R +
Sbjct: 952 AS--------PQ-FSSHSKLITPAPSSLPHSRRALSPEMHAVTSEWISLTVGVPGRRSLA 1002
Query: 625 VSPLRTQNSPSRLPATSL--RPHSVVSPQHSHQ-----PPVQMCPRP---------AIPL 668
++P LP S+ H +SP+ S P + RP A+P
Sbjct: 1003 LTPPLPP-----LPEASIYNTDHLALSPRASPSLSLSLPHLSWSDRPTPRSVASPLALPS 1057
Query: 669 TSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLA 728
++ P + ++ ++NG+ G +P++ G D ++ L+
Sbjct: 1058 PHKTYSLAPTSQASLHMNGDGG--------VHTPSS-GIHQDSFLQLPLGSSDSVISQLS 1108
Query: 729 GASTKKKSRSP-PSVSPTHDPQVAVDALLQGAVGPEVSSLSI------------------ 769
A + + R P S ++ + A +G GP++S S
Sbjct: 1109 DAFSSQSKRQPWREESGQYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSD 1168
Query: 770 -----HGRAGSCPIESEMQGA--------MGMEPLHRKAGSLDLNFTSPSRQAPLSMAAI 816
R G P+ S G+ G E RKA S+Q +
Sbjct: 1169 LNTPEESRPGK-PLGSAFPGSEAEQTERHRGGEQAGRKAAR-----RGGSQQPQAQQRRV 1222
Query: 817 RPEPKLLPRE--RYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLF 874
P+ ++ Y+ + SY PQ++ E+EL++GDIV V +K +DGW+ GT +R + G F
Sbjct: 1223 TPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTF 1282
Query: 875 PGSFVE 880
PG++V+
Sbjct: 1283 PGNYVK 1288
Score = 73.9 bits (180), Expect = 6e-13
Identities = 36/68 (52%), Positives = 44/68 (64%), Gaps = 2/68 (2%)
Query: 458 TPPKVQLPLNV--YLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVF 515
TP + Q ++ Y ALY+Y PQ DELEL G++ V+EKC DGWF G S RT G F
Sbjct: 1223 TPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTF 1282
Query: 516 PGNYVTPV 523
PGNYV P+
Sbjct: 1283 PGNYVKPL 1290
Score = 45.8 bits (107), Expect = 2e-04
Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E
Sbjct: 799 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 848
Score = 40.8 bits (94), Expect = 0.006
Identities = 36/129 (27%), Positives = 54/129 (41%), Gaps = 20/129 (15%)
Query: 130 SPGGSPPARPI----PGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELATSR 185
+P S P +P+ PG A T GG AG A GS + A R
Sbjct: 1171 TPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGRK----------AARRGGSQQPQAQQR 1220
Query: 186 TAPAAKNPC---LLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ-- 240
++ L Y +ALYSY + +L+ GDI+ + K D+ W+ G T+
Sbjct: 1221 RVTPDRSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQF 1279
Query: 241 GFLPASYIQ 249
G P +Y++
Sbjct: 1280 GTFPGNYVK 1288
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 83.6 bits (205), Expect = 8e-16
Identities = 55/181 (30%), Positives = 90/181 (49%), Gaps = 18/181 (9%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
+A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P
Sbjct: 505 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 564
Query: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307
+ G+A+ F Q + ++F K E +T+LR+VDENW EG + + G
Sbjct: 565 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 622
Query: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAAS-SCNASLPSDSGAVASVAPSPTLSSSGAV 363
IFP+ YV++ K ++ MD P ++ S S AS V P + +S
Sbjct: 623 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLF 682
Query: 364 S 364
S
Sbjct: 683 S 683
Score = 81.3 bits (199), Expect = 4e-15
Identities = 42/90 (46%), Positives = 53/90 (58%), Gaps = 2/90 (2%)
Query: 436 SSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNV--YLALYAYKPQKSDELELHKGEMYRV 493
SSS + TA P+ + TP + Q ++ Y ALY+Y PQ DELEL G++ V
Sbjct: 649 SSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 708
Query: 494 LEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523
+EKC DGWF G S RT G FPGNYV P+
Sbjct: 709 MEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
Score = 63.2 bits (152), Expect = 1e-09
Identities = 35/93 (37%), Positives = 57/93 (61%), Gaps = 10/93 (10%)
Query: 798 LDLNFTS-PSRQAPLSMAAIRPEPKLLPRER---------YRVVVSYPPQSEAEIELKEG 847
+DL F+S PSR A S + + + + +R Y+ + SY PQ++ E+EL++G
Sbjct: 644 MDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 703
Query: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
DIV V +K +DGW+ GT +R + G FPG++V+
Sbjct: 704 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
Score = 45.8 bits (107), Expect = 2e-04
Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E
Sbjct: 505 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 554
Score = 37.0 bits (84), Expect = 0.081
Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505
+P A ++ TP +V L +A + + E+ KGE +L + + W++G
Sbjct: 556 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 614
Query: 506 SLRTGVSGVFPGNYVTPVSR 525
T G+FP YV + R
Sbjct: 615 IPGTSRQGIFPITYVDVIKR 634
Score = 35.8 bits (81), Expect = 0.18
Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
+ALYSY + +L+ GDI+ + K D+ W+ G T+ G P +Y++
Sbjct: 685 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
Score = 33.1 bits (74), Expect = 1.2
Identities = 10/43 (23%), Positives = 28/43 (65%)
Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+
Sbjct: 588 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 630
Score = 32.7 bits (73), Expect = 1.5
Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 2/50 (4%)
Query: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
A + +K Q EL L KG++ + ++ W++G G G+FP Y+
Sbjct: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 553
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 83.6 bits (205), Expect = 8e-16
Identities = 55/181 (30%), Positives = 90/181 (49%), Gaps = 18/181 (9%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
+A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P
Sbjct: 546 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 605
Query: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307
+ G+A+ F Q + ++F K E +T+LR+VDENW EG + + G
Sbjct: 606 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 663
Query: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAAS-SCNASLPSDSGAVASVAPSPTLSSSGAV 363
IFP+ YV++ K ++ MD P ++ S S AS V P + +S
Sbjct: 664 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLF 723
Query: 364 S 364
S
Sbjct: 724 S 724
Score = 81.3 bits (199), Expect = 4e-15
Identities = 42/90 (46%), Positives = 53/90 (58%), Gaps = 2/90 (2%)
Query: 436 SSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNV--YLALYAYKPQKSDELELHKGEMYRV 493
SSS + TA P+ + TP + Q ++ Y ALY+Y PQ DELEL G++ V
Sbjct: 690 SSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 749
Query: 494 LEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523
+EKC DGWF G S RT G FPGNYV P+
Sbjct: 750 MEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
Score = 63.2 bits (152), Expect = 1e-09
Identities = 35/93 (37%), Positives = 57/93 (61%), Gaps = 10/93 (10%)
Query: 798 LDLNFTS-PSRQAPLSMAAIRPEPKLLPRER---------YRVVVSYPPQSEAEIELKEG 847
+DL F+S PSR A S + + + + +R Y+ + SY PQ++ E+EL++G
Sbjct: 685 MDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 744
Query: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
DIV V +K +DGW+ GT +R + G FPG++V+
Sbjct: 745 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
Score = 45.8 bits (107), Expect = 2e-04
Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E
Sbjct: 546 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 595
Score = 37.0 bits (84), Expect = 0.081
Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505
+P A ++ TP +V L +A + + E+ KGE +L + + W++G
Sbjct: 597 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 655
Query: 506 SLRTGVSGVFPGNYVTPVSR 525
T G+FP YV + R
Sbjct: 656 IPGTSRQGIFPITYVDVIKR 675
Score = 35.8 bits (81), Expect = 0.18
Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
+ALYSY + +L+ GDI+ + K D+ W+ G T+ G P +Y++
Sbjct: 726 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
Score = 33.1 bits (74), Expect = 1.2
Identities = 10/43 (23%), Positives = 28/43 (65%)
Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+
Sbjct: 629 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 671
Score = 32.7 bits (73), Expect = 1.5
Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 2/50 (4%)
Query: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
A + +K Q EL L KG++ + ++ W++G G G+FP Y+
Sbjct: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 594
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 83.6 bits (205), Expect = 8e-16
Identities = 55/181 (30%), Positives = 90/181 (49%), Gaps = 18/181 (9%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
+A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P
Sbjct: 581 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 640
Query: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307
+ G+A+ F Q + ++F K E +T+LR+VDENW EG + + G
Sbjct: 641 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 698
Query: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAAS-SCNASLPSDSGAVASVAPSPTLSSSGAV 363
IFP+ YV++ K ++ MD P ++ S S AS V P + +S
Sbjct: 699 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLF 758
Query: 364 S 364
S
Sbjct: 759 S 759
Score = 81.3 bits (199), Expect = 4e-15
Identities = 42/90 (46%), Positives = 53/90 (58%), Gaps = 2/90 (2%)
Query: 436 SSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNV--YLALYAYKPQKSDELELHKGEMYRV 493
SSS + TA P+ + TP + Q ++ Y ALY+Y PQ DELEL G++ V
Sbjct: 725 SSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 784
Query: 494 LEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523
+EKC DGWF G S RT G FPGNYV P+
Sbjct: 785 MEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
Score = 63.2 bits (152), Expect = 1e-09
Identities = 35/93 (37%), Positives = 57/93 (61%), Gaps = 10/93 (10%)
Query: 798 LDLNFTS-PSRQAPLSMAAIRPEPKLLPRER---------YRVVVSYPPQSEAEIELKEG 847
+DL F+S PSR A S + + + + +R Y+ + SY PQ++ E+EL++G
Sbjct: 720 MDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 779
Query: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
DIV V +K +DGW+ GT +R + G FPG++V+
Sbjct: 780 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 812
Score = 45.8 bits (107), Expect = 2e-04
Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E
Sbjct: 581 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 630
Score = 37.0 bits (84), Expect = 0.081
Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505
+P A ++ TP +V L +A + + E+ KGE +L + + W++G
Sbjct: 632 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 690
Query: 506 SLRTGVSGVFPGNYVTPVSR 525
T G+FP YV + R
Sbjct: 691 IPGTSRQGIFPITYVDVIKR 710
Score = 35.8 bits (81), Expect = 0.18
Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
+ALYSY + +L+ GDI+ + K D+ W+ G T+ G P +Y++
Sbjct: 761 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 812
Score = 33.1 bits (74), Expect = 1.2
Identities = 10/43 (23%), Positives = 28/43 (65%)
Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+
Sbjct: 664 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 706
Score = 32.7 bits (73), Expect = 1.5
Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 2/50 (4%)
Query: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
A + +K Q EL L KG++ + ++ W++G G G+FP Y+
Sbjct: 582 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 629
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 83.6 bits (205), Expect = 8e-16
Identities = 55/181 (30%), Positives = 90/181 (49%), Gaps = 18/181 (9%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
+A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P
Sbjct: 449 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 508
Query: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307
+ G+A+ F Q + ++F K E +T+LR+VDENW EG + + G
Sbjct: 509 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 566
Query: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAAS-SCNASLPSDSGAVASVAPSPTLSSSGAV 363
IFP+ YV++ K ++ MD P ++ S S AS V P + +S
Sbjct: 567 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLF 626
Query: 364 S 364
S
Sbjct: 627 S 627
Score = 81.3 bits (199), Expect = 4e-15
Identities = 42/90 (46%), Positives = 53/90 (58%), Gaps = 2/90 (2%)
Query: 436 SSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNV--YLALYAYKPQKSDELELHKGEMYRV 493
SSS + TA P+ + TP + Q ++ Y ALY+Y PQ DELEL G++ V
Sbjct: 593 SSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 652
Query: 494 LEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523
+EKC DGWF G S RT G FPGNYV P+
Sbjct: 653 MEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
Score = 63.2 bits (152), Expect = 1e-09
Identities = 35/93 (37%), Positives = 57/93 (61%), Gaps = 10/93 (10%)
Query: 798 LDLNFTS-PSRQAPLSMAAIRPEPKLLPRER---------YRVVVSYPPQSEAEIELKEG 847
+DL F+S PSR A S + + + + +R Y+ + SY PQ++ E+EL++G
Sbjct: 588 MDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 647
Query: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
DIV V +K +DGW+ GT +R + G FPG++V+
Sbjct: 648 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 680
Score = 45.8 bits (107), Expect = 2e-04
Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E
Sbjct: 449 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 498
Score = 37.0 bits (84), Expect = 0.081
Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505
+P A ++ TP +V L +A + + E+ KGE +L + + W++G
Sbjct: 500 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 558
Query: 506 SLRTGVSGVFPGNYVTPVSR 525
T G+FP YV + R
Sbjct: 559 IPGTSRQGIFPITYVDVIKR 578
Score = 35.8 bits (81), Expect = 0.18
Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
+ALYSY + +L+ GDI+ + K D+ W+ G T+ G P +Y++
Sbjct: 629 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 680
Score = 33.1 bits (74), Expect = 1.2
Identities = 10/43 (23%), Positives = 28/43 (65%)
Query: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+
Sbjct: 532 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 574
Score = 32.7 bits (73), Expect = 1.5
Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 2/50 (4%)
Query: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
A + +K Q EL L KG++ + ++ W++G G G+FP Y+
Sbjct: 450 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 497
>gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens]
Length = 368
Score = 76.3 bits (186), Expect = 1e-13
Identities = 46/142 (32%), Positives = 70/142 (49%), Gaps = 5/142 (3%)
Query: 115 VRLLDGIRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGST 174
V++LD + ++ + S P R + P G + G P + AA+ S
Sbjct: 230 VQILDELAEKLKRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSF 289
Query: 175 AGSLRELAT-SRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYH 233
S + + T SR+ P P KALY +E + G+L F++GD+I L ++DE WY
Sbjct: 290 RSSDKPIRTPSRSMPPLDQPSC----KALYDFEPENDGELGFHEGDVITLTNQIDENWYE 345
Query: 234 GELHGTQGFLPASYIQCIQPLP 255
G L G GF P SY++ + PLP
Sbjct: 346 GMLDGQSGFFPLSYVEVLVPLP 367
Score = 54.7 bits (130), Expect = 4e-07
Identities = 27/62 (43%), Positives = 39/62 (62%), Gaps = 4/62 (6%)
Query: 255 PHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYV 314
P P KALYDFE ++ + L F + +++T+ ++DENW EGML + G FPL YV
Sbjct: 305 PLDQPSCKALYDFEPENDGE----LGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360
Query: 315 EL 316
E+
Sbjct: 361 EV 362
Score = 43.1 bits (100), Expect = 0.001
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 10/99 (10%)
Query: 437 SSAGSTPTAVPRAASVSGEQG------TPPKVQLPLNV--YLALYAYKPQKSDELELHKG 488
S+ G T P+ A+ S + TP + PL+ ALY ++P+ EL H+G
Sbjct: 271 SNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEG 330
Query: 489 EMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVP 527
++ + + + W++G + G SG FP +YV + +P
Sbjct: 331 DVITLTNQIDENWYEG--MLDGQSGFFPLSYVEVLVPLP 367
Score = 42.4 bits (98), Expect = 0.002
Identities = 23/84 (27%), Positives = 43/84 (51%), Gaps = 13/84 (15%)
Query: 797 SLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR 856
S D +PSR P L + + + + P+++ E+ EGD++ + +
Sbjct: 291 SSDKPIRTPSRSMPP-----------LDQPSCKALYDFEPENDGELGFHEGDVITLTNQI 339
Query: 857 EDGWYKGTLQRNGRTGLFPGSFVE 880
++ WY+G L +G++G FP S+VE
Sbjct: 340 DENWYEGML--DGQSGFFPLSYVE 361
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 72.0 bits (175), Expect = 2e-12
Identities = 55/186 (29%), Positives = 86/186 (46%), Gaps = 35/186 (18%)
Query: 151 GGGGGAAGSTPGSPVFLSAAAGS-TAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKE 209
G G AG P + V L + GS TAG +T K P + + + SY
Sbjct: 1041 GTVGDKAGVFPSNYVRLKDSEGSGTAG--------KTGSLGKKPEI---AQVIASYTATG 1089
Query: 210 PGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ-----GFLPASYIQCIQP-----LPHAPP 259
P L G +I++R+K W+ GEL G+ PA+Y++ + P P PP
Sbjct: 1090 PEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPP 1149
Query: 260 QGKAL---------YDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFP 310
+ AL YD+ ++ D+ L F K +I+ VL + D +W +G + ++G+FP
Sbjct: 1150 KSTALAAVCQVIGMYDYTAQNDDE----LAFNKGQIINVLNKEDPDWWKGEVNGQVGLFP 1205
Query: 311 LLYVEL 316
YV+L
Sbjct: 1206 SNYVKL 1211
Score = 68.9 bits (167), Expect = 2e-11
Identities = 54/184 (29%), Positives = 86/184 (46%), Gaps = 44/184 (23%)
Query: 174 TAGSLRELA--TSRTAPAAKNPCLLPYGK--------ALYSYEGKEPGDLKFNKGDIIVL 223
+AG LR+ + T TA + +L G+ ALY + K+ L FNK D+I +
Sbjct: 883 SAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITV 942
Query: 224 RRKVDEQWYHGELHGTQGFLPASYIQCIQ-PL----------------------PHAPP- 259
+ D W+ GE+ G +G+ P SY++ I P+ P A P
Sbjct: 943 LEQQD-MWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPV 1001
Query: 260 ----QGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVE 315
+ A+Y +E ++ LTF + +++ V ++ D +W G +GDK G+FP YV
Sbjct: 1002 VSGEEFIAMYTYESSEQGD----LTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVR 1056
Query: 316 LNDS 319
L DS
Sbjct: 1057 LKDS 1060
Score = 54.7 bits (130), Expect = 4e-07
Identities = 44/184 (23%), Positives = 78/184 (42%), Gaps = 25/184 (13%)
Query: 167 LSAAAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRK 226
+ + + + SL+ +A+ P + A+Y+YE E GDL F +GD+I++ +K
Sbjct: 979 MDSGSSESPASLKRVASPAAKPVVSGEEFI----AMYTYESSEQGDLTFQQGDVILVTKK 1034
Query: 227 VDEQWYHGELHGTQGFLPASYIQC-----------IQPLPHAPPQGKALYDFEMKDKDQD 275
D W+ G + G P++Y++ L P + + + +Q
Sbjct: 1035 -DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQ- 1092
Query: 276 KDCLTFTKDEILTVLRRVDENWAEGML---GDK--IGIFPLLYVELNDSAKQLIEMDKPC 330
LT +++ + ++ W EG L G K IG FP YV+L I +P
Sbjct: 1093 ---LTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPP 1149
Query: 331 PAAA 334
+ A
Sbjct: 1150 KSTA 1153
Score = 50.8 bits (120), Expect = 5e-06
Identities = 83/365 (22%), Positives = 130/365 (35%), Gaps = 71/365 (19%)
Query: 198 YGKALYSYEGKEPGDLKFNKGDIIVLRRK-VDEQ------WYHGELHGTQGFLPASYIQC 250
Y +ALY +E + ++ GDI++++ + VDE W GEL G G+ PA+Y +
Sbjct: 744 YYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEK 803
Query: 251 IQ----PLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKI 306
I P P P + L T E T NWA D
Sbjct: 804 IPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPST----TPNNWA-----DFS 854
Query: 307 GIFPLLYVELNDSAKQLIEMDKP---CPAAASSCNASLPSDSGAVASVAPSPTLSSSGAV 363
+P E ++ +P P+A S + + A S +PSP L V
Sbjct: 855 STWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGS-SPSPVLGQGEKV 913
Query: 364 SAFQRRV--------DGKKNTKKRHSFTALSVTHR--SSQAASHRHSMEISAPVLISSSD 413
Q + D N K T L + + S LIS
Sbjct: 914 EGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPI 973
Query: 414 PRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAAS------VSGEQGTPPKVQLPLN 467
++ + + S + +P ++ R AS VSGE+
Sbjct: 974 RKSTS----------------MDSGSSESPASLKRVASPAAKPVVSGEE----------- 1006
Query: 468 VYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVP 527
++A+Y Y+ + +L +G++ V +K D W + +GVFP NYV
Sbjct: 1007 -FIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDK---AGVFPSNYVRLKDSEG 1062
Query: 528 AGGAG 532
+G AG
Sbjct: 1063 SGTAG 1067
Score = 47.8 bits (112), Expect = 5e-05
Identities = 77/318 (24%), Positives = 119/318 (37%), Gaps = 67/318 (21%)
Query: 262 KALYDFEMKDKDQ---DKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELND 318
+ALY FE + D+ + K E + + + W G L K G FP Y E
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE--- 802
Query: 319 SAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKK 378
++ E + P P + + S P+ A+ P+P +S S
Sbjct: 803 ---KIPENEVPAPVKPVTDSTSAPAPKLALRET-PAPLAVTSSEPST---------TPNN 849
Query: 379 RHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSS 438
F++ T + + + + P L S G L S P +++
Sbjct: 850 WADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPS-------AGQLRQRSAFTP----ATA 898
Query: 439 AGSTPTAV-PRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKC 497
GS+P+ V + V G Q ALY ++ +K + L +K ++ VLE+
Sbjct: 899 TGSSPSPVLGQGEKVEGLQAQ------------ALYPWRAKKDNHLNFNKNDVITVLEQ- 945
Query: 498 QDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSG 557
QD W+ G G G FP +YV +S GP R +T+M SG
Sbjct: 946 QDMWWFGEV--QGQKGWFPKSYVKLIS-------GPIRK------------STSM--DSG 982
Query: 558 SLSSLATATRPALPITTP 575
S S A+ R A P P
Sbjct: 983 SSESPASLKRVASPAAKP 1000
Score = 47.4 bits (111), Expect = 6e-05
Identities = 98/439 (22%), Positives = 158/439 (35%), Gaps = 76/439 (17%)
Query: 469 YLALYAYKPQKSDELELHKGEMYRVLEKCQD-------GWFKGASLRTGVSGVFPGNYVT 521
Y ALY ++ + DE+ + G++ V + D GW G L+ G +G FP NY
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWL-GGELK-GKTGWFPANYAE 802
Query: 522 PVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQH 581
+ P N V +P+ +T P LA PA P A
Sbjct: 803 KI----------PENEVP--APVKPVTDSTSAPAP----KLALRETPA-----PLAVTSS 841
Query: 582 PTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATV---SPLRTQNSPSRLP 638
++ P S PT++ + AAQ P+ TV LR +++ +
Sbjct: 842 EPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQ----PSLTVPSAGQLRQRSAFTPAT 897
Query: 639 ATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLS 698
AT P V+ Q +Q A A+ P N I VL
Sbjct: 898 ATGSSPSPVLG-QGEKVEGLQ------------AQALYPWRAKKDNHLNFNKNDVITVLE 944
Query: 699 TSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSR-SPPSVSPTHDPQVAVDALLQ 757
G E + +K +KL++G K S S S SP +VA A
Sbjct: 945 QQDMWWFG----EVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKP 1000
Query: 758 GAVGPEVSSLSIHGRA---------GSCPIESEMQGAMGMEPLHRKAGSLDLNFT----S 804
G E ++ + + G + ++ G + KAG N+ S
Sbjct: 1001 VVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDS 1060
Query: 805 PSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGT 864
++ +P++ +V+ SY ++ L G ++ + KK GW++G
Sbjct: 1061 EGSGTAGKTGSLGKKPEIA-----QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGE 1115
Query: 865 LQRNGR---TGLFPGSFVE 880
LQ G+ G FP ++V+
Sbjct: 1116 LQARGKKRQIGWFPANYVK 1134
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/51 (41%), Positives = 28/51 (54%), Gaps = 2/51 (3%)
Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
+ +Y Y Q DEL +KG++ VL K W+KG G G+FP NYV
Sbjct: 1161 IGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV--NGQVGLFPSNYV 1209
Score = 39.3 bits (90), Expect = 0.016
Identities = 17/47 (36%), Positives = 29/47 (61%), Gaps = 2/47 (4%)
Query: 834 YPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Y Q++ E+ +G I+ V K + W+KG + NG+ GLFP ++V+
Sbjct: 1166 YTAQNDDELAFNKGQIINVLNKEDPDWWKGEV--NGQVGLFPSNYVK 1210
Score = 36.6 bits (83), Expect = 0.11
Identities = 28/87 (32%), Positives = 41/87 (47%), Gaps = 13/87 (14%)
Query: 805 PSRQAPLSMAAIRP----EPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFV-------H 853
P+ QAP S A P + + YR + + +S EI ++ GDIV V
Sbjct: 718 PAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDES 777
Query: 854 KKREDGWYKGTLQRNGRTGLFPGSFVE 880
+ E GW G L+ G+TG FP ++ E
Sbjct: 778 QTGEPGWLGGELK--GKTGWFPANYAE 802
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 72.0 bits (175), Expect = 2e-12
Identities = 55/186 (29%), Positives = 86/186 (46%), Gaps = 35/186 (18%)
Query: 151 GGGGGAAGSTPGSPVFLSAAAGS-TAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKE 209
G G AG P + V L + GS TAG +T K P + + + SY
Sbjct: 1041 GTVGDKAGVFPSNYVRLKDSEGSGTAG--------KTGSLGKKPEI---AQVIASYTATG 1089
Query: 210 PGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ-----GFLPASYIQCIQP-----LPHAPP 259
P L G +I++R+K W+ GEL G+ PA+Y++ + P P PP
Sbjct: 1090 PEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPP 1149
Query: 260 QGKAL---------YDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFP 310
+ AL YD+ ++ D+ L F K +I+ VL + D +W +G + ++G+FP
Sbjct: 1150 KSTALAAVCQVIGMYDYTAQNDDE----LAFNKGQIINVLNKEDPDWWKGEVNGQVGLFP 1205
Query: 311 LLYVEL 316
YV+L
Sbjct: 1206 SNYVKL 1211
Score = 68.9 bits (167), Expect = 2e-11
Identities = 54/184 (29%), Positives = 86/184 (46%), Gaps = 44/184 (23%)
Query: 174 TAGSLRELA--TSRTAPAAKNPCLLPYGK--------ALYSYEGKEPGDLKFNKGDIIVL 223
+AG LR+ + T TA + +L G+ ALY + K+ L FNK D+I +
Sbjct: 883 SAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITV 942
Query: 224 RRKVDEQWYHGELHGTQGFLPASYIQCIQ-PL----------------------PHAPP- 259
+ D W+ GE+ G +G+ P SY++ I P+ P A P
Sbjct: 943 LEQQD-MWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPV 1001
Query: 260 ----QGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVE 315
+ A+Y +E ++ LTF + +++ V ++ D +W G +GDK G+FP YV
Sbjct: 1002 VSGEEFIAMYTYESSEQGD----LTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVR 1056
Query: 316 LNDS 319
L DS
Sbjct: 1057 LKDS 1060
Score = 54.7 bits (130), Expect = 4e-07
Identities = 44/184 (23%), Positives = 78/184 (42%), Gaps = 25/184 (13%)
Query: 167 LSAAAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRK 226
+ + + + SL+ +A+ P + A+Y+YE E GDL F +GD+I++ +K
Sbjct: 979 MDSGSSESPASLKRVASPAAKPVVSGEEFI----AMYTYESSEQGDLTFQQGDVILVTKK 1034
Query: 227 VDEQWYHGELHGTQGFLPASYIQC-----------IQPLPHAPPQGKALYDFEMKDKDQD 275
D W+ G + G P++Y++ L P + + + +Q
Sbjct: 1035 -DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQ- 1092
Query: 276 KDCLTFTKDEILTVLRRVDENWAEGML---GDK--IGIFPLLYVELNDSAKQLIEMDKPC 330
LT +++ + ++ W EG L G K IG FP YV+L I +P
Sbjct: 1093 ---LTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPP 1149
Query: 331 PAAA 334
+ A
Sbjct: 1150 KSTA 1153
Score = 50.8 bits (120), Expect = 5e-06
Identities = 83/365 (22%), Positives = 130/365 (35%), Gaps = 71/365 (19%)
Query: 198 YGKALYSYEGKEPGDLKFNKGDIIVLRRK-VDEQ------WYHGELHGTQGFLPASYIQC 250
Y +ALY +E + ++ GDI++++ + VDE W GEL G G+ PA+Y +
Sbjct: 744 YYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEK 803
Query: 251 IQ----PLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKI 306
I P P P + L T E T NWA D
Sbjct: 804 IPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPST----TPNNWA-----DFS 854
Query: 307 GIFPLLYVELNDSAKQLIEMDKP---CPAAASSCNASLPSDSGAVASVAPSPTLSSSGAV 363
+P E ++ +P P+A S + + A S +PSP L V
Sbjct: 855 STWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGS-SPSPVLGQGEKV 913
Query: 364 SAFQRRV--------DGKKNTKKRHSFTALSVTHR--SSQAASHRHSMEISAPVLISSSD 413
Q + D N K T L + + S LIS
Sbjct: 914 EGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPI 973
Query: 414 PRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAAS------VSGEQGTPPKVQLPLN 467
++ + + S + +P ++ R AS VSGE+
Sbjct: 974 RKSTS----------------MDSGSSESPASLKRVASPAAKPVVSGEE----------- 1006
Query: 468 VYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVP 527
++A+Y Y+ + +L +G++ V +K D W + +GVFP NYV
Sbjct: 1007 -FIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDK---AGVFPSNYVRLKDSEG 1062
Query: 528 AGGAG 532
+G AG
Sbjct: 1063 SGTAG 1067
Score = 47.8 bits (112), Expect = 5e-05
Identities = 77/318 (24%), Positives = 119/318 (37%), Gaps = 67/318 (21%)
Query: 262 KALYDFEMKDKDQ---DKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELND 318
+ALY FE + D+ + K E + + + W G L K G FP Y E
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE--- 802
Query: 319 SAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKK 378
++ E + P P + + S P+ A+ P+P +S S
Sbjct: 803 ---KIPENEVPAPVKPVTDSTSAPAPKLALRET-PAPLAVTSSEPST---------TPNN 849
Query: 379 RHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSS 438
F++ T + + + + P L S G L S P +++
Sbjct: 850 WADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPS-------AGQLRQRSAFTP----ATA 898
Query: 439 AGSTPTAV-PRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKC 497
GS+P+ V + V G Q ALY ++ +K + L +K ++ VLE+
Sbjct: 899 TGSSPSPVLGQGEKVEGLQAQ------------ALYPWRAKKDNHLNFNKNDVITVLEQ- 945
Query: 498 QDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSG 557
QD W+ G G G FP +YV +S GP R +T+M SG
Sbjct: 946 QDMWWFGEV--QGQKGWFPKSYVKLIS-------GPIRK------------STSM--DSG 982
Query: 558 SLSSLATATRPALPITTP 575
S S A+ R A P P
Sbjct: 983 SSESPASLKRVASPAAKP 1000
Score = 47.4 bits (111), Expect = 6e-05
Identities = 98/439 (22%), Positives = 158/439 (35%), Gaps = 76/439 (17%)
Query: 469 YLALYAYKPQKSDELELHKGEMYRVLEKCQD-------GWFKGASLRTGVSGVFPGNYVT 521
Y ALY ++ + DE+ + G++ V + D GW G L+ G +G FP NY
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWL-GGELK-GKTGWFPANYAE 802
Query: 522 PVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQH 581
+ P N V +P+ +T P LA PA P A
Sbjct: 803 KI----------PENEVP--APVKPVTDSTSAPAP----KLALRETPA-----PLAVTSS 841
Query: 582 PTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATV---SPLRTQNSPSRLP 638
++ P S PT++ + AAQ P+ TV LR +++ +
Sbjct: 842 EPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQ----PSLTVPSAGQLRQRSAFTPAT 897
Query: 639 ATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLS 698
AT P V+ Q +Q A A+ P N I VL
Sbjct: 898 ATGSSPSPVLG-QGEKVEGLQ------------AQALYPWRAKKDNHLNFNKNDVITVLE 944
Query: 699 TSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSR-SPPSVSPTHDPQVAVDALLQ 757
G E + +K +KL++G K S S S SP +VA A
Sbjct: 945 QQDMWWFG----EVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKP 1000
Query: 758 GAVGPEVSSLSIHGRA---------GSCPIESEMQGAMGMEPLHRKAGSLDLNFT----S 804
G E ++ + + G + ++ G + KAG N+ S
Sbjct: 1001 VVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDS 1060
Query: 805 PSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGT 864
++ +P++ +V+ SY ++ L G ++ + KK GW++G
Sbjct: 1061 EGSGTAGKTGSLGKKPEIA-----QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGE 1115
Query: 865 LQRNGR---TGLFPGSFVE 880
LQ G+ G FP ++V+
Sbjct: 1116 LQARGKKRQIGWFPANYVK 1134
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/51 (41%), Positives = 28/51 (54%), Gaps = 2/51 (3%)
Query: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
+ +Y Y Q DEL +KG++ VL K W+KG G G+FP NYV
Sbjct: 1161 IGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV--NGQVGLFPSNYV 1209
Score = 39.3 bits (90), Expect = 0.016
Identities = 17/47 (36%), Positives = 29/47 (61%), Gaps = 2/47 (4%)
Query: 834 YPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Y Q++ E+ +G I+ V K + W+KG + NG+ GLFP ++V+
Sbjct: 1166 YTAQNDDELAFNKGQIINVLNKEDPDWWKGEV--NGQVGLFPSNYVK 1210
Score = 36.6 bits (83), Expect = 0.11
Identities = 28/87 (32%), Positives = 41/87 (47%), Gaps = 13/87 (14%)
Query: 805 PSRQAPLSMAAIRP----EPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFV-------H 853
P+ QAP S A P + + YR + + +S EI ++ GDIV V
Sbjct: 718 PAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDES 777
Query: 854 KKREDGWYKGTLQRNGRTGLFPGSFVE 880
+ E GW G L+ G+TG FP ++ E
Sbjct: 778 QTGEPGWLGGELK--GKTGWFPANYAE 802
>gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]
Length = 352
Score = 68.6 bits (166), Expect = 3e-11
Identities = 28/60 (46%), Positives = 39/60 (65%)
Query: 197 PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPH 256
P +ALY +E + G+L F +GDII L ++DE WY G LHG GF P +Y++ + LPH
Sbjct: 293 PCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH 352
Score = 51.6 bits (122), Expect = 3e-06
Identities = 25/58 (43%), Positives = 38/58 (65%), Gaps = 4/58 (6%)
Query: 259 PQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVEL 316
P +ALYDFE +++ + L F + +I+T+ ++DENW EGML G FP+ YVE+
Sbjct: 293 PCCRALYDFEPENEGE----LGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEI 346
Score = 45.4 bits (106), Expect = 2e-04
Identities = 19/52 (36%), Positives = 34/52 (65%), Gaps = 2/52 (3%)
Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
R + + P++E E+ KEGDI+ + + ++ WY+G L +G +G FP ++VE
Sbjct: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGML--HGHSGFFPINYVE 345
Score = 42.4 bits (98), Expect = 0.002
Identities = 36/145 (24%), Positives = 64/145 (44%), Gaps = 23/145 (15%)
Query: 392 SQAASHRHSMEISAPVLI--------SSSDPRAAARIGDLAHLSCAAPTQDVSS-SAGST 442
+Q H+ +++I V + +SS PR + +S PT D + + G +
Sbjct: 221 AQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQ--PKPRMSLEFPTGDSTQPNGGLS 278
Query: 443 PTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWF 502
T P+ P VQ+ ALY ++P+ EL +G++ + + + W+
Sbjct: 279 HTGTPK----------PSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWY 328
Query: 503 KGASLRTGVSGVFPGNYVTPVSRVP 527
+G + G SG FP NYV + +P
Sbjct: 329 EG--MLHGHSGFFPINYVEILVALP 351
>gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens]
Length = 347
Score = 67.4 bits (163), Expect = 6e-11
Identities = 27/59 (45%), Positives = 38/59 (64%)
Query: 197 PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLP 255
P + LY +E + G+L F +GDII L ++DE WY G +HG GF P +Y++ I PLP
Sbjct: 288 PCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLP 346
Score = 51.2 bits (121), Expect = 4e-06
Identities = 24/63 (38%), Positives = 40/63 (63%), Gaps = 4/63 (6%)
Query: 254 LPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLY 313
+P P + LYDFE +++ + L F + +I+T+ ++DENW EGM+ + G FP+ Y
Sbjct: 283 IPMDQPCCRGLYDFEPENQGE----LGFKEGDIITLTNQIDENWYEGMIHGESGFFPINY 338
Query: 314 VEL 316
VE+
Sbjct: 339 VEV 341
Score = 42.4 bits (98), Expect = 0.002
Identities = 17/52 (32%), Positives = 34/52 (65%), Gaps = 2/52 (3%)
Query: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
R + + P+++ E+ KEGDI+ + + ++ WY+G + +G +G FP ++VE
Sbjct: 291 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMI--HGESGFFPINYVE 340
Score = 37.4 bits (85), Expect = 0.062
Identities = 17/56 (30%), Positives = 31/56 (55%), Gaps = 2/56 (3%)
Query: 472 LYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVP 527
LY ++P+ EL +G++ + + + W++G + G SG FP NYV + +P
Sbjct: 293 LYDFEPENQGELGFKEGDIITLTNQIDENWYEG--MIHGESGFFPINYVEVIVPLP 346
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 67.0 bits (162), Expect = 7e-11
Identities = 78/355 (21%), Positives = 133/355 (37%), Gaps = 76/355 (21%)
Query: 203 YSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQ------PLP- 255
+ Y+ + +L + G+II RK D W+ G+++G +G P ++++ I+ PL
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN 67
Query: 256 -------HAPPQGKALYDFE-------------------MKDKDQDKDCLTFTKDEILTV 289
H P G +L E Q+ D L +I+ V
Sbjct: 68 KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127
Query: 290 LRRVDENWAEGMLGDKIGIFPLLYV-ELNDSAKQL-IEMDKPCPAAASSCNASLPSDSGA 347
+ V+E W EG+L K G+FP ++ EL+ + +L I D+ +SL +G+
Sbjct: 128 VGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDE------QLSKSSLRETTGS 181
Query: 348 VASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPV 407
+ S + S GA K K + S+E+
Sbjct: 182 ESDGGDSSSTKSEGANGTVATAAIQPKKVKG----VGFGDIFKDKPIKLRPRSIEVENDF 237
Query: 408 LISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLN 467
L P + TA P ++ + T K +
Sbjct: 238 L----------------------PVEKTIGKKLPATTATPDSSKTEMDSRTKSK-----D 270
Query: 468 VYLALYAYKPQKSDELELHKGEMYRVLEK-CQD-GWFKGASLRTGVSGVFPGNYV 520
++ Y+ Q DEL + +G++ ++ K C D GW++G G GVFP N+V
Sbjct: 271 YCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGE--LNGRRGVFPDNFV 323
Score = 65.5 bits (158), Expect = 2e-10
Identities = 46/116 (39%), Positives = 65/116 (56%), Gaps = 7/116 (6%)
Query: 769 IHGRAGSCP--IESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRE 826
I+GR G P E++ M +PL KA L+ PS + LS I K R
Sbjct: 41 INGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEV-PSGNSLLSSETILRTNKRGERR 99
Query: 827 RYR--VVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
R R V SY PQ++ E+ELK GDI+ V + E+GW++G L NG+TG+FP +F++
Sbjct: 100 RRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVL--NGKTGMFPSNFIK 153
Score = 46.2 bits (108), Expect = 1e-04
Identities = 19/52 (36%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 473 YAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVS 524
++Y PQ DELEL G++ V+ + ++GW++G + G +G+FP N++ +S
Sbjct: 107 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEG--VLNGKTGMFPSNFIKELS 156
Score = 45.8 bits (107), Expect = 2e-04
Identities = 19/58 (32%), Positives = 34/58 (58%), Gaps = 2/58 (3%)
Query: 198 YGKALYSYEGKEPGDLKFNKGDIIVLRRK--VDEQWYHGELHGTQGFLPASYIQCIQP 253
Y K ++ YE + +L +GDI+ L K +D W+ GEL+G +G P ++++ + P
Sbjct: 271 YCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPP 328
Score = 45.1 bits (105), Expect = 3e-04
Identities = 25/78 (32%), Positives = 44/78 (56%), Gaps = 4/78 (5%)
Query: 805 PSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR--EDGWYK 862
P+ A + + + ++ +V+ Y Q++ E+ +KEGDIV + K + GW++
Sbjct: 249 PATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWE 308
Query: 863 GTLQRNGRTGLFPGSFVE 880
G L NGR G+FP +FV+
Sbjct: 309 GEL--NGRRGVFPDNFVK 324
Score = 41.2 bits (95), Expect = 0.004
Identities = 20/50 (40%), Positives = 30/50 (60%), Gaps = 2/50 (4%)
Query: 830 VVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFV 879
V Y Q + E+ + G+I+ +K + GW++G Q NGR GLFP +FV
Sbjct: 6 VEFDYQAQHDDELTISVGEIITNIRKEDGGWWEG--QINGRRGLFPDNFV 53
Score = 40.0 bits (92), Expect = 0.010
Identities = 23/89 (25%), Positives = 42/89 (47%), Gaps = 5/89 (5%)
Query: 161 PGSPVFLSAAAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDI 220
P P+ + S S L T++ + C + +SY + +L+ GDI
Sbjct: 70 PEKPLHEVPSGNSLLSSETILRTNKRGERRRRRC-----QVAFSYLPQNDDELELKVGDI 124
Query: 221 IVLRRKVDEQWYHGELHGTQGFLPASYIQ 249
I + +V+E W+ G L+G G P+++I+
Sbjct: 125 IEVVGEVEEGWWEGVLNGKTGMFPSNFIK 153
Score = 36.2 bits (82), Expect = 0.14
Identities = 28/91 (30%), Positives = 42/91 (46%), Gaps = 14/91 (15%)
Query: 258 PPQGKALYDFEMKDKD----------QDKDCLTFTKDEILTVLRR--VDENWAEGMLGDK 305
P K D K KD Q+ D LT + +I+T++ + +D W EG L +
Sbjct: 255 PDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGR 314
Query: 306 IGIFPLLYVEL--NDSAKQLIEMDKPCPAAA 334
G+FP +V+L D K+ KP P +A
Sbjct: 315 RGVFPDNFVKLLPPDFEKEGNRPKKPPPPSA 345
Score = 35.4 bits (80), Expect = 0.23
Identities = 17/53 (32%), Positives = 28/53 (52%), Gaps = 2/53 (3%)
Query: 473 YAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSR 525
+ Y+ Q DEL + GE+ + K GW++G G G+FP N+V + +
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQI--NGRRGLFPDNFVREIKK 58
>gi|119943102 CREB binding protein isoform b [Homo sapiens]
Length = 2404
Score = 63.9 bits (154), Expect = 6e-10
Identities = 105/439 (23%), Positives = 170/439 (38%), Gaps = 64/439 (14%)
Query: 414 PRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALY 473
PRAA+ + ++ ++ S P+ +P+ ++ G Q P
Sbjct: 703 PRAASPMNHSVQMNSMGSVPGMAIS----PSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQ 758
Query: 474 AYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNY---VTPVSRVPAGG 530
P S + + G+ Q G GA+L ++ + P PV++ P
Sbjct: 759 NQFPSSSGAMSVGMGQPPAQTGVSQ-GQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHP 817
Query: 531 AGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQHPTASPPTGS 590
PP + G L M P A T+P+ P+++ Q PT +P
Sbjct: 818 TPPPASTAAGMPSLQHTTPPGMTPPQP-----AAPTQPSTPVSSS---GQTPTPTP---- 865
Query: 591 CLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSP 650
+ P+A+Q +ST + A AAQAQ P P T ++P SV +P
Sbjct: 866 ----GSVPSATQTQSTPTVQA--AAQAQVTPQ---------------PQTPVQPPSVATP 904
Query: 651 QHSHQPPVQM-CPRPAIPLTSAASAI-----TPPNVSAANLNGEAGGGPIGVLSTSSPTN 704
Q S Q P + P PL+ AA++I TP +V++A N + G + VL + T
Sbjct: 905 QSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQ 964
Query: 705 TGCKLDEKKSEKKEKKSGLLKL-LAGASTKK------KSRSPPSVSPTHDPQVAVDALLQ 757
+ K E +S +++ L GAS K + +S P P+V V+
Sbjct: 965 AEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEV--- 1021
Query: 758 GAVGPEVSSLSIHGRAGSCPIESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIR 817
E S +G A S+ + + R+A L + RQ P S+ +
Sbjct: 1022 ----KEEEESSSNGTASQSTSPSQPRKKIFKPEELRQA--LMPTLEALYRQDPESLPFRQ 1075
Query: 818 P-EPKLLPRERYRVVVSYP 835
P +P+LL Y +V P
Sbjct: 1076 PVDPQLLGIPDYFDIVKNP 1094
Score = 32.0 bits (71), Expect = 2.6
Identities = 30/113 (26%), Positives = 46/113 (40%), Gaps = 11/113 (9%)
Query: 534 PRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQHPTASP-----PT 588
P+ +++ G P A + PG +SL+ R P+ +P+ +Q P +SP P
Sbjct: 2278 PQQHMLSGQPQASHL-----PGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQ 2332
Query: 589 GSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATS 641
S H + T S T A S Q + L N+PSR +S
Sbjct: 2333 PS-PHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSS 2384
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,054,407
Number of Sequences: 37866
Number of extensions: 2218825
Number of successful extensions: 16345
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 319
Number of HSP's successfully gapped in prelim test: 894
Number of HSP's that attempted gapping in prelim test: 12030
Number of HSP's gapped (non-prelim): 4585
length of query: 882
length of database: 18,247,518
effective HSP length: 111
effective length of query: 771
effective length of database: 14,044,392
effective search space: 10828226232
effective search space used: 10828226232
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.