Guide to the Human Genome
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Search of human proteins with 149999613

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|149999613 TBC1 domain family, member 3B [Homo sapiens]
         (549 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|149999613 TBC1 domain family, member 3B [Homo sapiens]            1152   0.0  
gi|90577185 TBC1 domain family member 3C [Homo sapiens]              1146   0.0  
gi|157502205 TBC1 domain family, member 3G [Homo sapiens]            1144   0.0  
gi|226693407 TBC1 domain family, member 3H [Homo sapiens]            1142   0.0  
gi|183583563 TBC1 domain family, member 3D [Homo sapiens]            1142   0.0  
gi|183583565 TBC1 domain family, member 3 [Homo sapiens]             1140   0.0  
gi|183583567 TBC1 domain family, member 3E [Homo sapiens]            1140   0.0  
gi|14149985 TBC1 domain family, member 3F [Homo sapiens]             1137   0.0  
gi|109638751 ubiquitin specific protease 6 [Homo sapiens]             841   0.0  
gi|239756926 PREDICTED: similar to TBC1 domain family, member 3 ...   491   e-139
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]              244   1e-64
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]            244   1e-64
gi|148235002 TBC1 domain family, member 26 [Homo sapiens]             236   4e-62
gi|239745813 PREDICTED: hypothetical protein XP_002343595 [Homo ...   186   5e-47
gi|239756790 PREDICTED: similar to hCG1991532 [Homo sapiens]          181   1e-45
gi|239756750 PREDICTED: similar to TBC1 domain family, member 28...   171   2e-42
gi|151108489 TBC1 domain family, member 28 [Homo sapiens]             171   2e-42
gi|239751314 PREDICTED: hypothetical protein XP_002347802 [Homo ...   154   2e-37
gi|239756746 PREDICTED: TBC1 domain family, member 27 [Homo sapi...   125   8e-29
gi|239751241 PREDICTED: TBC1 domain family, member 27 [Homo sapi...   125   1e-28
gi|239745731 PREDICTED: TBC1 domain family, member 27 [Homo sapi...   125   1e-28
gi|167614488 TBC1 domain family, member 10B [Homo sapiens]            104   2e-22
gi|38348348 TBC1 domain family, member 10C [Homo sapiens]             103   3e-22
gi|13994322 TBC1 domain family, member 10A [Homo sapiens]             103   4e-22
gi|68299759 ecotropic viral integration site 5 [Homo sapiens]          84   3e-16
gi|7661586 TBC1 domain family, member 29 [Homo sapiens]                84   4e-16
gi|229577000 ecotropic viral integration site 5-like isoform 1 [...    81   2e-15
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H...    81   2e-15
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]    81   3e-15
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]    81   3e-15

>gi|149999613 TBC1 domain family, member 3B [Homo sapiens]
          Length = 549

 Score = 1152 bits (2979), Expect = 0.0
 Identities = 549/549 (100%), Positives = 549/549 (100%)

Query: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60
           MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL
Sbjct: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60

Query: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120
           TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM
Sbjct: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120

Query: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY 180
           KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY
Sbjct: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY 180

Query: 181 NPEVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240
           NPEVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE
Sbjct: 181 NPEVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240

Query: 241 HVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300
           HVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI
Sbjct: 241 HVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300

Query: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP 360
           TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP
Sbjct: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP 360

Query: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420
           AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA
Sbjct: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420

Query: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480
           VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV
Sbjct: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480

Query: 481 RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQYAPTSGPCLCGLHL 540
           RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQYAPTSGPCLCGLHL
Sbjct: 481 RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQYAPTSGPCLCGLHL 540

Query: 541 ESSQFPPGF 549
           ESSQFPPGF
Sbjct: 541 ESSQFPPGF 549


>gi|90577185 TBC1 domain family member 3C [Homo sapiens]
          Length = 549

 Score = 1146 bits (2964), Expect = 0.0
 Identities = 547/549 (99%), Positives = 547/549 (99%)

Query: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60
           MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL
Sbjct: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60

Query: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120
           TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM
Sbjct: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120

Query: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY 180
           KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY
Sbjct: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY 180

Query: 181 NPEVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240
           NPEVGYCRDLSHIAALFLLY PEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE
Sbjct: 181 NPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240

Query: 241 HVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300
           HVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI
Sbjct: 241 HVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300

Query: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP 360
           TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP
Sbjct: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP 360

Query: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420
           AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA
Sbjct: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420

Query: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480
           VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV
Sbjct: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480

Query: 481 RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQYAPTSGPCLCGLHL 540
           RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQ APTSGPCLCGLHL
Sbjct: 481 RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHL 540

Query: 541 ESSQFPPGF 549
           ESSQFPPGF
Sbjct: 541 ESSQFPPGF 549


>gi|157502205 TBC1 domain family, member 3G [Homo sapiens]
          Length = 549

 Score = 1144 bits (2959), Expect = 0.0
 Identities = 546/549 (99%), Positives = 546/549 (99%)

Query: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60
           MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL
Sbjct: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60

Query: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120
           TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM
Sbjct: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120

Query: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY 180
           KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY
Sbjct: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY 180

Query: 181 NPEVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240
           NPEVGYCRDLSHIAALFLLY PEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE
Sbjct: 181 NPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240

Query: 241 HVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300
           HVVATSQ KTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI
Sbjct: 241 HVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300

Query: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP 360
           TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP
Sbjct: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP 360

Query: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420
           AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA
Sbjct: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420

Query: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480
           VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV
Sbjct: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480

Query: 481 RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQYAPTSGPCLCGLHL 540
           RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQ APTSGPCLCGLHL
Sbjct: 481 RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHL 540

Query: 541 ESSQFPPGF 549
           ESSQFPPGF
Sbjct: 541 ESSQFPPGF 549


>gi|226693407 TBC1 domain family, member 3H [Homo sapiens]
          Length = 549

 Score = 1142 bits (2955), Expect = 0.0
 Identities = 545/549 (99%), Positives = 546/549 (99%)

Query: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60
           MDVVEVAGSWWAQEREDIIMKYEKGH+AGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL
Sbjct: 1   MDVVEVAGSWWAQEREDIIMKYEKGHQAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60

Query: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120
           TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM
Sbjct: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120

Query: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY 180
           KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY
Sbjct: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY 180

Query: 181 NPEVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240
           NPEVGYCRDLSHIAALFLLY PEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE
Sbjct: 181 NPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240

Query: 241 HVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300
           HVVATSQ KTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI
Sbjct: 241 HVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300

Query: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP 360
           TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP
Sbjct: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP 360

Query: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420
           AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA
Sbjct: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420

Query: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480
           VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV
Sbjct: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480

Query: 481 RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQYAPTSGPCLCGLHL 540
           RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQ APTSGPCLCGLHL
Sbjct: 481 RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHL 540

Query: 541 ESSQFPPGF 549
           ESSQFPPGF
Sbjct: 541 ESSQFPPGF 549


>gi|183583563 TBC1 domain family, member 3D [Homo sapiens]
          Length = 549

 Score = 1142 bits (2954), Expect = 0.0
 Identities = 544/549 (99%), Positives = 546/549 (99%)

Query: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60
           MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL
Sbjct: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60

Query: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120
           TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM
Sbjct: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120

Query: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY 180
           KLKNPGRYQIMKEKGKRSSEHIQRIDRD+SGTLRKH+FFRDRYGTKQRELLHILLAYEEY
Sbjct: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEY 180

Query: 181 NPEVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240
           NPEVGYCRDLSHIAALFLLY PEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE
Sbjct: 181 NPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240

Query: 241 HVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300
           HVVATSQ KTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI
Sbjct: 241 HVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300

Query: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP 360
           TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP
Sbjct: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP 360

Query: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420
           AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA
Sbjct: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420

Query: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480
           VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV
Sbjct: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480

Query: 481 RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQYAPTSGPCLCGLHL 540
           RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQ APTSGPCLCGLHL
Sbjct: 481 RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHL 540

Query: 541 ESSQFPPGF 549
           ESSQFPPGF
Sbjct: 541 ESSQFPPGF 549


>gi|183583565 TBC1 domain family, member 3 [Homo sapiens]
          Length = 549

 Score = 1140 bits (2950), Expect = 0.0
 Identities = 543/549 (98%), Positives = 546/549 (99%)

Query: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60
           MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL
Sbjct: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60

Query: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120
           TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM
Sbjct: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120

Query: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY 180
           KLKNPGRYQIMKEKGKRSSEHIQRIDRD+SGTLRKH+FFRDRYGTKQRELLHILLAYEEY
Sbjct: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEY 180

Query: 181 NPEVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240
           NPEVGYCRDLSHIAALFLLY PEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE
Sbjct: 181 NPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240

Query: 241 HVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300
           HVVATSQ KTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI
Sbjct: 241 HVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300

Query: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP 360
           TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRK+GDLPPP
Sbjct: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKKGDLPPP 360

Query: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420
           AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA
Sbjct: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420

Query: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480
           VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV
Sbjct: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480

Query: 481 RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQYAPTSGPCLCGLHL 540
           RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQ APTSGPCLCGLHL
Sbjct: 481 RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHL 540

Query: 541 ESSQFPPGF 549
           ESSQFPPGF
Sbjct: 541 ESSQFPPGF 549


>gi|183583567 TBC1 domain family, member 3E [Homo sapiens]
          Length = 549

 Score = 1140 bits (2950), Expect = 0.0
 Identities = 543/549 (98%), Positives = 546/549 (99%)

Query: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60
           MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL
Sbjct: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60

Query: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120
           TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM
Sbjct: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120

Query: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY 180
           KLKNPGRYQIMKEKGKRSSEHIQRIDRD+SGTLRKH+FFRDRYGTKQRELLHILLAYEEY
Sbjct: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEY 180

Query: 181 NPEVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240
           NPEVGYCRDLSHIAALFLLY PEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE
Sbjct: 181 NPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240

Query: 241 HVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300
           HVVATSQ KTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI
Sbjct: 241 HVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300

Query: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP 360
           TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRK+GDLPPP
Sbjct: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKKGDLPPP 360

Query: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420
           AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA
Sbjct: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420

Query: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480
           VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV
Sbjct: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480

Query: 481 RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQYAPTSGPCLCGLHL 540
           RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQ APTSGPCLCGLHL
Sbjct: 481 RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHL 540

Query: 541 ESSQFPPGF 549
           ESSQFPPGF
Sbjct: 541 ESSQFPPGF 549


>gi|14149985 TBC1 domain family, member 3F [Homo sapiens]
          Length = 549

 Score = 1137 bits (2942), Expect = 0.0
 Identities = 541/549 (98%), Positives = 545/549 (99%)

Query: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60
           MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL
Sbjct: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60

Query: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120
           TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLN EEM
Sbjct: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEM 120

Query: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY 180
           KLKNPGRYQIMKEKGK+SSEHIQRIDRD+SGTLRKH+FFRDRYGTKQRELLHILLAYEEY
Sbjct: 121 KLKNPGRYQIMKEKGKKSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEY 180

Query: 181 NPEVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240
           NPEVGYCRDLSHIAALFLLY PEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE
Sbjct: 181 NPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240

Query: 241 HVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300
           HVVATSQ KTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI
Sbjct: 241 HVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300

Query: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP 360
           TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRK+GDLPPP
Sbjct: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKKGDLPPP 360

Query: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420
           AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA
Sbjct: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420

Query: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480
           VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV
Sbjct: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480

Query: 481 RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQYAPTSGPCLCGLHL 540
           RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQ APTSGPCLCGLHL
Sbjct: 481 RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHL 540

Query: 541 ESSQFPPGF 549
           ESSQFPPGF
Sbjct: 541 ESSQFPPGF 549


>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
          Length = 1406

 Score =  841 bits (2172), Expect = 0.0
 Identities = 405/500 (81%), Positives = 438/500 (87%), Gaps = 1/500 (0%)

Query: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60
           MD+VE A S  AQER+DI+MKY+KGHRAGLPEDKGP+P    N+++D  GI+HETELPP+
Sbjct: 1   MDMVENADSLQAQERKDILMKYDKGHRAGLPEDKGPEPV-GINSSIDRFGILHETELPPV 59

Query: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120
           TAREAK+IRRE++R SKW++MLG+WE YK S KLIDR YKG+PMNIRGP+WSVLLNI+E+
Sbjct: 60  TAREAKKIRREMTRTSKWMEMLGEWETYKHSSKLIDRVYKGIPMNIRGPVWSVLLNIQEI 119

Query: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEY 180
           KLKNPGRYQIMKE+GKRSSEHI  ID D+  TLR H+FFRDRYG KQREL +ILLAY EY
Sbjct: 120 KLKNPGRYQIMKERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRELFYILLAYSEY 179

Query: 181 NPEVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE 240
           NPEVGYCRDLSHI ALFLLY PEEDAFWALVQLLASERHSL GFHSPNGGTVQGLQDQQE
Sbjct: 180 NPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQE 239

Query: 241 HVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300
           HVV  SQ KTM HQDK+ LCGQC+ LGCL+R LIDGISLGLTLRLWDVYLVEGEQ LMPI
Sbjct: 240 HVVPKSQPKTMWHQDKEGLCGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPI 299

Query: 301 TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP 360
           T IA KVQQKRL KTSRCG WAR  N+F DTWA ++DTVLKHLRAS KKLTRKQGDLPPP
Sbjct: 300 TSIALKVQQKRLMKTSRCGLWARLRNQFFDTWAMNDDTVLKHLRASTKKLTRKQGDLPPP 359

Query: 361 AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA 420
           AK EQGS A RPVPASRGGKTLCKG RQAPPGPPA+F RPI SASPP A R STPCPGGA
Sbjct: 360 AKREQGSLAPRPVPASRGGKTLCKGYRQAPPGPPAQFQRPICSASPPWASRFSTPCPGGA 419

Query: 421 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV 480
           VREDTYPVGTQGVPS ALAQGGPQGSWRFL+W SMPRLPTDLD+ GPWF HYDF  SCWV
Sbjct: 420 VREDTYPVGTQGVPSLALAQGGPQGSWRFLEWKSMPRLPTDLDIGGPWFPHYDFEWSCWV 479

Query: 481 RAISQEDQLAPCWQAEHPAE 500
           RAISQEDQLA CWQAEH  E
Sbjct: 480 RAISQEDQLATCWQAEHCGE 499


>gi|239756926 PREDICTED: similar to TBC1 domain family, member 3
           [Homo sapiens]
          Length = 424

 Score =  491 bits (1264), Expect = e-139
 Identities = 229/240 (95%), Positives = 231/240 (96%)

Query: 310 KRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSA 369
           KRLTKTSRCGPWARF NRFVD WARD+DTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSA
Sbjct: 185 KRLTKTSRCGPWARFWNRFVDAWARDDDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSA 244

Query: 370 SRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVG 429
           SRPVPASRGGKTLCKGDRQAPPGPPARFP PIWSASPPRAPRSSTPCPGGAVREDTYPVG
Sbjct: 245 SRPVPASRGGKTLCKGDRQAPPGPPARFPWPIWSASPPRAPRSSTPCPGGAVREDTYPVG 304

Query: 430 TQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQL 489
           TQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDV  PWFR YDFRQSCWVRAISQEDQ 
Sbjct: 305 TQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVGDPWFRRYDFRQSCWVRAISQEDQP 364

Query: 490 APCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQYAPTSGPCLCGLHLESSQFPPGF 549
           A CWQAEHPAERVRSAF+APSTDSDQGTPFRARDEQQ APTSGPCLCGLHLESSQFPPGF
Sbjct: 365 ATCWQAEHPAERVRSAFSAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF 424



 Score =  311 bits (798), Expect = 8e-85
 Identities = 144/165 (87%), Positives = 157/165 (95%)

Query: 1   MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL 60
           MDVVEV GSWWAQEREDIIMKYEKGHRAGLPEDKGPKPF SYNNN+DH G+ HETELPPL
Sbjct: 1   MDVVEVVGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFGSYNNNIDHFGMQHETELPPL 60

Query: 61  TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM 120
           TARE KQIRREISRKSKWV MLG+W+ YK+SRKLIDRAY+G+PMNIRGPMWSVLLNIEE+
Sbjct: 61  TAREVKQIRREISRKSKWVKMLGEWDTYKNSRKLIDRAYQGIPMNIRGPMWSVLLNIEEI 120

Query: 121 KLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGT 165
           KLKNPGRYQIMKEKGKRSSEHIQ++D D+SGTLR+H+FFRDRYGT
Sbjct: 121 KLKNPGRYQIMKEKGKRSSEHIQQMDLDVSGTLRRHIFFRDRYGT 165


>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
          Length = 828

 Score =  244 bits (624), Expect = 1e-64
 Identities = 148/434 (34%), Positives = 216/434 (49%), Gaps = 25/434 (5%)

Query: 12  AQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRRE 71
           AQER +I+ KY++G      E      +  Y    D  G +HE ELP       +Q   E
Sbjct: 12  AQERAEIVAKYDRGREGAEIEPWEDADYLVYKVT-DRFGFLHEEELPDHNVAVERQKHLE 70

Query: 72  ISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
           I R +KW+ ML  WEKYK++ K   R YKG+P+ +RG +W++LL I +MK +    Y  +
Sbjct: 71  IERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKL 130

Query: 132 KEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
           K + +  S  I++ID D++ T R H+ FRDRYG KQ+ L H+L AY  YN EVGYC+ +S
Sbjct: 131 KHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMS 190

Query: 192 HIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQSKTM 251
            I AL L+Y  EEDAFWALV+L +  +H++ GF       +   Q+  E ++    SK  
Sbjct: 191 QITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLK 250

Query: 252 GHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKR 311
            H D +++      +    +  +D     L LR+WD+Y+ EGE+ L  ++    K+ +K 
Sbjct: 251 QHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKH 310

Query: 312 LTKTSRCGPWARFCNRFVDTWARD----EDTVLKHLRASMKKLTRKQGDLPPPAK----P 363
           L K S           F +T A+D    +D V++ L+ SM +L R + DLP P K    P
Sbjct: 311 LMKLS----MEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKEDEYP 366

Query: 364 EQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVRE 423
           ++      P   S G   L  G R    G P          SP  + R  +  P      
Sbjct: 367 KKPLGQLPPELQSWGVHHLSNGQRSV--GRP----------SPLASGRRESGAPHRRHEH 414

Query: 424 DTYPVGTQGVPSPA 437
             +P    G P  A
Sbjct: 415 SPHPQSRTGTPERA 428


>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
          Length = 845

 Score =  244 bits (624), Expect = 1e-64
 Identities = 148/434 (34%), Positives = 216/434 (49%), Gaps = 25/434 (5%)

Query: 12  AQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRRE 71
           AQER +I+ KY++G      E      +  Y    D  G +HE ELP       +Q   E
Sbjct: 29  AQERAEIVAKYDRGREGAEIEPWEDADYLVYKVT-DRFGFLHEEELPDHNVAVERQKHLE 87

Query: 72  ISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
           I R +KW+ ML  WEKYK++ K   R YKG+P+ +RG +W++LL I +MK +    Y  +
Sbjct: 88  IERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKL 147

Query: 132 KEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
           K + +  S  I++ID D++ T R H+ FRDRYG KQ+ L H+L AY  YN EVGYC+ +S
Sbjct: 148 KHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMS 207

Query: 192 HIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQSKTM 251
            I AL L+Y  EEDAFWALV+L +  +H++ GF       +   Q+  E ++    SK  
Sbjct: 208 QITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLK 267

Query: 252 GHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKR 311
            H D +++      +    +  +D     L LR+WD+Y+ EGE+ L  ++    K+ +K 
Sbjct: 268 QHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKH 327

Query: 312 LTKTSRCGPWARFCNRFVDTWARD----EDTVLKHLRASMKKLTRKQGDLPPPAK----P 363
           L K S           F +T A+D    +D V++ L+ SM +L R + DLP P K    P
Sbjct: 328 LMKLS----MEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKEDEYP 383

Query: 364 EQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVRE 423
           ++      P   S G   L  G R    G P          SP  + R  +  P      
Sbjct: 384 KKPLGQLPPELQSWGVHHLSNGQRSV--GRP----------SPLASGRRESGAPHRRHEH 431

Query: 424 DTYPVGTQGVPSPA 437
             +P    G P  A
Sbjct: 432 SPHPQSRTGTPERA 445


>gi|148235002 TBC1 domain family, member 26 [Homo sapiens]
          Length = 250

 Score =  236 bits (602), Expect = 4e-62
 Identities = 121/206 (58%), Positives = 147/206 (71%), Gaps = 5/206 (2%)

Query: 18  IIMKYEKGHRAGLPEDKGPKPF--RSYNNNVDHLGIVHETELPPLTAREAKQIRREISRK 75
           II KYE+GHRAG   D G +    R Y NN   LGIVHE ELP ++A E KQ R+E  R 
Sbjct: 19  IITKYEQGHRAGAAVDLGHEQVDVRKYTNN---LGIVHEMELPRVSALEVKQRRKESKRT 75

Query: 76  SKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKG 135
           +KW  ML DW KY+S++KL  R YK +P+ +RG  WS+LL+I+ +K +NPG+Y++MKEKG
Sbjct: 76  NKWQKMLADWTKYRSTKKLSQRVYKVIPLAVRGRAWSLLLDIDRIKSQNPGKYKVMKEKG 135

Query: 136 KRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAA 195
           KRSS  I  I  D+S TL+KHM F  R+G KQ+EL  IL+AY  YNPEVGY RDLS I A
Sbjct: 136 KRSSRIIHCIQLDVSHTLQKHMMFIQRFGVKQQELCDILVAYSAYNPEVGYHRDLSRITA 195

Query: 196 LFLLYFPEEDAFWALVQLLASERHSL 221
           + LL  PEEDAFWAL QLLA ERHSL
Sbjct: 196 ILLLCLPEEDAFWALTQLLAGERHSL 221


>gi|239745813 PREDICTED: hypothetical protein XP_002343595 [Homo
           sapiens]
          Length = 279

 Score =  186 bits (472), Expect = 5e-47
 Identities = 105/209 (50%), Positives = 122/209 (58%), Gaps = 22/209 (10%)

Query: 279 LGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDT 338
           +GL  R   +    G     PI  +      K L K SR G WARF ++F  TWA D D 
Sbjct: 79  VGLPRRRSGLVSRAGHSDAEPIPHVTQMKVGKHLMKASRSGLWARFQDQFPQTWALDSDA 138

Query: 339 VLKHLRASMKKLTRKQGDLPPPAKPEQGSSASRPVPASR-GGKTLCKGDRQAPPGPPARF 397
           VL+HL+AS+             +KP+QGSSA RP  AS  G KTLCKG RQAPPGP A F
Sbjct: 139 VLRHLQASVL------------SKPKQGSSAPRPELASPCGRKTLCKGSRQAPPGPQAHF 186

Query: 398 PRPIWSASPPRAPRSSTPCPGGAVREDTYPVG-TQGVPSPALAQGGPQGSWRFLQWNSMP 456
            + IWSASPP  P   TPCP          VG +QGVP  A AQGGP+ SWR+LQWNS+P
Sbjct: 187 QQCIWSASPPWVPLPFTPCP--------VLVGLSQGVPRLAPAQGGPRVSWRYLQWNSLP 238

Query: 457 RLPTDLDVEGPWFRHYDFRQSCWVRAISQ 485
           +LP D DV  PWF HYDF Q CW R  S+
Sbjct: 239 QLPMDSDVVSPWFPHYDFEQGCWARVPSK 267


>gi|239756790 PREDICTED: similar to hCG1991532 [Homo sapiens]
          Length = 167

 Score =  181 bits (460), Expect = 1e-45
 Identities = 97/174 (55%), Positives = 111/174 (63%), Gaps = 22/174 (12%)

Query: 314 KTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSASRPV 373
           K SR G WARF ++F  TWA D D VL+HL+AS+             +KP+QGSSA RP 
Sbjct: 2   KASRSGLWARFQDQFPQTWALDSDAVLRHLQASVL------------SKPKQGSSAPRPE 49

Query: 374 PASR-GGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVG-TQ 431
            AS  G KTLCKG RQAPPGP A F + IWSASPP  P   TPCP          VG +Q
Sbjct: 50  LASPCGRKTLCKGSRQAPPGPQAHFQQRIWSASPPWVPLPFTPCP--------VLVGLSQ 101

Query: 432 GVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQ 485
           GVP  A AQGGP+ SWR+LQWNS+P+LP D DV  PWF HYDF Q CW R  S+
Sbjct: 102 GVPRLAPAQGGPRVSWRYLQWNSLPQLPMDSDVVSPWFPHYDFEQGCWARVPSK 155


>gi|239756750 PREDICTED: similar to TBC1 domain family, member 28
           [Homo sapiens]
          Length = 234

 Score =  171 bits (432), Expect = 2e-42
 Identities = 89/167 (53%), Positives = 115/167 (68%), Gaps = 5/167 (2%)

Query: 18  IIMKYEKGHRAGLPEDKGPKPF--RSYNNNVDHLGIVHETELPPLTAREAKQIRREISRK 75
           II KYE+GHRAG   D G +    R Y NN   LGIVHE ELP ++A E KQ R+E  R 
Sbjct: 43  IITKYEQGHRAGAAVDLGHEQVDVRKYTNN---LGIVHEMELPHVSALEVKQRRKESKRT 99

Query: 76  SKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKG 135
           +KW  ML DW KY+S++KL  R  K +P+ +RG   S+LL+I+++K +NPG+Y++MKEKG
Sbjct: 100 NKWQKMLADWTKYRSTKKLSQRVCKVIPLAVRGRALSLLLDIDKIKSQNPGKYKVMKEKG 159

Query: 136 KRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNP 182
           KRSS  I  I  D+S TL+KHM F  R+G KQ+EL  IL+AY  YNP
Sbjct: 160 KRSSRIIHCIQLDVSHTLQKHMMFIQRFGVKQQELCDILVAYSAYNP 206


>gi|151108489 TBC1 domain family, member 28 [Homo sapiens]
          Length = 210

 Score =  171 bits (432), Expect = 2e-42
 Identities = 89/167 (53%), Positives = 115/167 (68%), Gaps = 5/167 (2%)

Query: 18  IIMKYEKGHRAGLPEDKGPKPF--RSYNNNVDHLGIVHETELPPLTAREAKQIRREISRK 75
           II KYE+GHRAG   D G +    R Y NN   LGIVHE ELP ++A E KQ R+E  R 
Sbjct: 19  IITKYEQGHRAGAAVDLGHEQVDVRKYTNN---LGIVHEMELPRVSALEVKQRRKESKRT 75

Query: 76  SKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKG 135
           +KW  ML DW KY+S++KL  R  K +P+ +RG   S+LL+I+++K +NPG+Y++MKEKG
Sbjct: 76  NKWQKMLADWTKYRSTKKLSQRVCKVIPLAVRGRALSLLLDIDKIKSQNPGKYKVMKEKG 135

Query: 136 KRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNP 182
           KRSS  I  I  D+S TL+KHM F  R+G KQ+EL  IL+AY  YNP
Sbjct: 136 KRSSRIIHCIQLDVSHTLQKHMMFIQRFGVKQQELCDILVAYSAYNP 182


>gi|239751314 PREDICTED: hypothetical protein XP_002347802 [Homo
           sapiens]
          Length = 179

 Score =  154 bits (389), Expect = 2e-37
 Identities = 93/190 (48%), Positives = 108/190 (56%), Gaps = 27/190 (14%)

Query: 300 ITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDE--DTVLKHLRASMKKLTRKQGDL 357
           + R AFKVQ+ + T    C  W    +      A+ +   TV   L +S           
Sbjct: 1   MARTAFKVQRSKST----CAQWGLGSSGVRPRLAQGQLPHTVPMFLCSS----------- 45

Query: 358 PPPAKPEQGSSASRPVPASR-GGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPC 416
           P  AKP+QGSSA RP  AS  G KTLCKG RQAPPGP A F + IWSASPP  P   TPC
Sbjct: 46  PEEAKPKQGSSAPRPELASPCGRKTLCKGSRQAPPGPQAHFQQCIWSASPPWVPLPFTPC 105

Query: 417 PGGAVREDTYPVG-TQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFR 475
           P          VG +QGVP  A AQGGP+ SWR+LQWNS+P+LP D DV  PWF HYDF 
Sbjct: 106 P--------VLVGLSQGVPRLAPAQGGPRVSWRYLQWNSLPQLPMDSDVVSPWFPHYDFE 157

Query: 476 QSCWVRAISQ 485
           Q CW R  S+
Sbjct: 158 QGCWARVPSK 167


>gi|239756746 PREDICTED: TBC1 domain family, member 27 [Homo
           sapiens]
          Length = 339

 Score =  125 bits (315), Expect = 8e-29
 Identities = 89/217 (41%), Positives = 119/217 (54%), Gaps = 22/217 (10%)

Query: 183 EVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHV 242
           EVGY RDLS   A+ LLY PEEDAFW  V   A+ R        PN   ++ L   QE V
Sbjct: 56  EVGYHRDLSRNTAV-LLYLPEEDAFW--VAGSAAGR--------PNTAQLRKLLSHQEQV 104

Query: 243 VATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITR 302
           +  S  K M    K+ LC + S L  L++  +DG S GLTLRLWDV ++EGEQ L  +  
Sbjct: 105 LHKSFPKIMRQLGKEGLCIEGSMLTRLLQCFLDGKSFGLTLRLWDVLILEGEQVLTAMAH 164

Query: 303 IAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAK 362
            +FK+ ++ L K S    W  F  R   +WA ++++VL++L+ SMK+LT+K  DLP P  
Sbjct: 165 ASFKIHREHLMKLSWSTVW-EFQERLSQSWALEDNSVLRNLQTSMKELTKKHWDLPSPES 223

Query: 363 PEQGSSASRPVPA----SRGGKTLC----KGDRQAPP 391
             Q  +A R   A    S+ GK  C     GD +A P
Sbjct: 224 LLQ--NAHRCTIAWGLQSKAGKNSCTSRASGDFRAHP 258


>gi|239751241 PREDICTED: TBC1 domain family, member 27 [Homo
           sapiens]
          Length = 617

 Score =  125 bits (314), Expect = 1e-28
 Identities = 86/215 (40%), Positives = 116/215 (53%), Gaps = 18/215 (8%)

Query: 183 EVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHV 242
           EVGY RDLS   A+ LLY PEEDAFW  V   A+ R        PN   ++ L   QE V
Sbjct: 186 EVGYHRDLSRNTAV-LLYLPEEDAFW--VAGSAAGR--------PNTAQLRKLLSHQEQV 234

Query: 243 VATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITR 302
           +  S  K M    K+ LC + S L  L++  +DG S GLTLRLWDV ++EGEQ L  +  
Sbjct: 235 LHKSFPKIMRQLGKEGLCIEGSMLTRLLQCFLDGKSFGLTLRLWDVLILEGEQVLTAMAH 294

Query: 303 IAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAK 362
            +FK+ ++ L K S    W  F  R   +WA ++++VL++L+ SMK+LT+K  DLP P  
Sbjct: 295 ASFKIHREHLMKLSWSTVW-EFQERLSQSWALEDNSVLRNLQTSMKELTKKHWDLPSPES 353

Query: 363 PEQGSSASRPV--PASRGGKTLC----KGDRQAPP 391
             Q +          S+ GK  C     GD +A P
Sbjct: 354 LLQNAHCCTIAWGLQSKAGKNSCTSRASGDFRAHP 388


>gi|239745731 PREDICTED: TBC1 domain family, member 27 [Homo
           sapiens]
          Length = 339

 Score =  125 bits (314), Expect = 1e-28
 Identities = 86/215 (40%), Positives = 116/215 (53%), Gaps = 18/215 (8%)

Query: 183 EVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHV 242
           EVGY RDLS   A+ LLY PEEDAFW  V   A+ R        PN   ++ L   QE V
Sbjct: 56  EVGYHRDLSRNTAV-LLYLPEEDAFW--VAGSAAGR--------PNTAQLRKLLSHQEQV 104

Query: 243 VATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITR 302
           +  S  K M    K+ LC + S L  L++  +DG S GLTLRLWDV ++EGEQ L  +  
Sbjct: 105 LHKSFPKIMRQLGKEGLCIEGSMLTRLLQCFLDGKSFGLTLRLWDVLILEGEQVLTAMAH 164

Query: 303 IAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAK 362
            +FK+ ++ L K S    W  F  R   +WA ++++VL++L+ SMK+LT+K  DLP P  
Sbjct: 165 ASFKIHREHLMKLSWSTVW-EFQERLSQSWALEDNSVLRNLQTSMKELTKKHWDLPSPES 223

Query: 363 PEQGSSASRPV--PASRGGKTLC----KGDRQAPP 391
             Q +          S+ GK  C     GD +A P
Sbjct: 224 LLQNAHCCTIAWGLQSKAGKNSCTSRASGDFRAHP 258


>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
          Length = 808

 Score =  104 bits (259), Expect = 2e-22
 Identities = 99/400 (24%), Positives = 167/400 (41%), Gaps = 40/400 (10%)

Query: 74  RKSKWVDMLGDWEKYKSSR--KLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
           R+ KW+DM  +W+K+ S R  K+  R  KG+P ++R   W  L N +E+  +NPG+++ +
Sbjct: 331 RELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEEL 390

Query: 132 KEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
            E+     + +  I++D+      H  F  R G  Q++L  IL AY  Y P+ GYC+  +
Sbjct: 391 -ERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQA 449

Query: 192 HIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQSKTM 251
            +AA+ L++ P E AFW LVQ+       L G++S     +Q   D +       ++  +
Sbjct: 450 PVAAVLLMHMPAEQAFWCLVQICDK---YLPGYYSAGLEAIQ--LDGEIFFALLRRASPL 504

Query: 252 GHQD--KKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQ 309
            H+   ++ +          + I    +     LR+WD++  EG + +  +  +  +   
Sbjct: 505 AHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTL 564

Query: 310 KRLTKTSRCGPWAR----------------FCNRFVDTWARDEDTVLKHLRASMKKLTRK 353
             + K   C                     F    V      E  + +   A +KK    
Sbjct: 565 GSVEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRET 624

Query: 354 QGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQ---APPGPPARFPRPIWSASPPRAP 410
           +G+L    +P +    SR +   R  +    G      + PG  +R  R    A  P  P
Sbjct: 625 RGEL--QYRPSRRLHGSRAIHEERRRQQPPLGPSSSLLSLPGLKSRGSRAAGGAPSPPPP 682

Query: 411 ---RSSTPCPGGAV-REDTYPVGTQGVPSPALAQGGPQGS 446
               S+ P PG  V  E  +P     +PSP      P GS
Sbjct: 683 VRRASAGPAPGPVVTAEGLHP----SLPSPT-GNSTPLGS 717


>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
          Length = 446

 Score =  103 bits (258), Expect = 3e-22
 Identities = 81/290 (27%), Positives = 126/290 (43%), Gaps = 24/290 (8%)

Query: 32  EDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSS 91
           E  GP P+R      D  G +  +   P        + R+  R+ KWV+M   WEK  S 
Sbjct: 27  ELSGPGPYRQ----ADRYGFIGGSSAEPGPGHPPADLIRQ--REMKWVEMTSHWEKTMSR 80

Query: 92  R--KLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDI 149
           R  K+  +  KG+P  +R   W +L      +  +PG YQ + E      + ++ I RD+
Sbjct: 81  RYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAE-APGDPQWMETIGRDL 139

Query: 150 SGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYFPEEDAFWA 209
                 H  F    G  Q+ LL +L AY  Y PE GYC+    +AA+ L++ P E+AFW 
Sbjct: 140 HRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWC 199

Query: 210 LVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQSKTMGHQDKKDLCGQCSPLGCL 269
           LVQ+       L G++ P+   V+        V      + + H  K        PL  L
Sbjct: 200 LVQIC---EVYLPGYYGPHMEAVR----LDAEVFMALLRRLLPHVHKHLQQVGVGPLLYL 252

Query: 270 ----IRILIDGISLGLTLRLWDVYLVEGEQAL----MPITRIAFKVQQKR 311
               + +    +     LR+WD +L EG + L    + + R+A    ++R
Sbjct: 253 PEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQR 302


>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
          Length = 508

 Score =  103 bits (257), Expect = 4e-22
 Identities = 71/241 (29%), Positives = 119/241 (49%), Gaps = 18/241 (7%)

Query: 74  RKSKWVDMLGDWEKY--KSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
           R+SKW+DML +W+K+  K  +K+  R  KG+P ++RG  W  L   +    +NPG++  +
Sbjct: 82  RESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDEL 141

Query: 132 KEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
            +      + +  I+RD+      H  F  R G  Q++L  +L AY  Y PE GYC+  +
Sbjct: 142 -DMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQA 200

Query: 192 HIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQS--- 248
            IAA+ L++ P E AFW LVQ+   E++ L G++S     ++ +Q   E + +  Q    
Sbjct: 201 PIAAVLLMHMPAEQAFWCLVQI--CEKY-LPGYYSEK---LEAIQLDGEILFSLLQKVSP 254

Query: 249 ---KTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAF 305
              K +  Q    L        C     +   S+   LR+WD++  EG + +  +  +  
Sbjct: 255 VAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSV---LRVWDMFFCEGVKIIFRVGLVLL 311

Query: 306 K 306
           K
Sbjct: 312 K 312


>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
          Length = 810

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 58/249 (23%), Positives = 113/249 (45%), Gaps = 9/249 (3%)

Query: 78  WVDMLGDWE--KYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKG 135
           W  ++ +WE  + K  +++ +  +KG+P + R  +W +L + + M +K+        E  
Sbjct: 138 WGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQ-----YSELL 192

Query: 136 KRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAA 195
           K +S   + I RDI+ T  +H FF+++    Q  L +++ AY   + EVGYC+  + I  
Sbjct: 193 KMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG 252

Query: 196 LFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQSKTMGHQD 255
           L L+  PEE+AF   V+L+   R  L+    P+   +     Q E ++     +   H  
Sbjct: 253 LLLMQMPEEEAFCVFVKLMQDYR--LRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQ 310

Query: 256 KKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKT 315
            +            + I +    L +  R++D+++ EG + +  +     ++ Q  L + 
Sbjct: 311 SQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQL 370

Query: 316 SRCGPWARF 324
              G    F
Sbjct: 371 DMEGMLQHF 379


>gi|7661586 TBC1 domain family, member 29 [Homo sapiens]
          Length = 150

 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 54/137 (39%), Positives = 75/137 (54%), Gaps = 10/137 (7%)

Query: 251 MGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQK 310
           MGH DK+ LC Q S    L+R+L DGISLGLT  LWD+YL+EGEQ LM IT IAFKVQ+ 
Sbjct: 1   MGHLDKEGLCTQGSSFSWLLRVLNDGISLGLTPCLWDMYLLEGEQMLMLITSIAFKVQRS 60

Query: 311 RLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSAS 370
              +T++   W     R +    R    + + L +S++ LT  +          +G S  
Sbjct: 61  LYEETNK-ETWGPATPRALKGTGRAR-PICESLHSSLQALTASES--------SRGPSLL 110

Query: 371 RPVPASRGGKTLCKGDR 387
           +  P   G + L +GD+
Sbjct: 111 QTPPRVPGQQALSRGDK 127


>gi|229577000 ecotropic viral integration site 5-like isoform 1
           [Homo sapiens]
          Length = 805

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 57/237 (24%), Positives = 109/237 (45%), Gaps = 9/237 (3%)

Query: 78  WVDMLGDWEKYKSSRK--LIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKG 135
           W  +  +WE+++  ++  L +   KG+P + R  +W +L +  +M +KN        E  
Sbjct: 90  WGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ-----YSELL 144

Query: 136 KRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAA 195
           K SS   + I RDI+ T  +H FF+ +    Q  L +++ AY   + EVGYC+  + I  
Sbjct: 145 KMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG 204

Query: 196 LFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQSKTMGHQD 255
           L L+  PEE+AF   V+L+  + + L+    P+   +     Q E+++         H  
Sbjct: 205 LLLMQMPEEEAFCVFVRLM--QEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFR 262

Query: 256 KKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRL 312
            +            + + +    L +  R++D+++ EG + +  +     +V Q  L
Sbjct: 263 SQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAEL 319


>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
           sapiens]
          Length = 794

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 57/237 (24%), Positives = 109/237 (45%), Gaps = 9/237 (3%)

Query: 78  WVDMLGDWEKYKSSRK--LIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKG 135
           W  +  +WE+++  ++  L +   KG+P + R  +W +L +  +M +KN        E  
Sbjct: 90  WGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ-----YSELL 144

Query: 136 KRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAA 195
           K SS   + I RDI+ T  +H FF+ +    Q  L +++ AY   + EVGYC+  + I  
Sbjct: 145 KMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG 204

Query: 196 LFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQSKTMGHQD 255
           L L+  PEE+AF   V+L+  + + L+    P+   +     Q E+++         H  
Sbjct: 205 LLLMQMPEEEAFCVFVRLM--QEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFR 262

Query: 256 KKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRL 312
            +            + + +    L +  R++D+++ EG + +  +     +V Q  L
Sbjct: 263 SQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAEL 319


>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
          Length = 963

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 57/254 (22%), Positives = 120/254 (47%), Gaps = 14/254 (5%)

Query: 70  REISRKSKWVDMLGDW--EKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKN--- 124
           +E+S   KW +        +   S +L +    G+P   R  +W   ++    K K+   
Sbjct: 629 QEVSTGVKWENYFASTVNREMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTE 688

Query: 125 PGRYQIMKEKG-KRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPE 183
           PG +Q + +K  ++ +   ++I+ D+  TL  +  +        ++L ++LLA+   NP+
Sbjct: 689 PGHFQTLLQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPD 748

Query: 184 VGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQ---E 240
           +GYC+ L+ + A+ LLY  +EDAFW LV ++  E    + +++    T+ G Q  Q    
Sbjct: 749 IGYCQGLNRLVAVALLYLEQEDAFWCLVTIV--EVFMPRDYYTK---TLLGSQVDQRVFR 803

Query: 241 HVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300
            +++    +  GH ++  +          + + +D +   +  ++WD +L EG + +   
Sbjct: 804 DLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRF 863

Query: 301 TRIAFKVQQKRLTK 314
               FK +++ + K
Sbjct: 864 ALALFKYKEEEILK 877


>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
          Length = 914

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 57/254 (22%), Positives = 120/254 (47%), Gaps = 14/254 (5%)

Query: 70  REISRKSKWVDMLGDW--EKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKN--- 124
           +E+S   KW +        +   S +L +    G+P   R  +W   ++    K K+   
Sbjct: 629 QEVSTGVKWENYFASTVNREMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTE 688

Query: 125 PGRYQIMKEKG-KRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPE 183
           PG +Q + +K  ++ +   ++I+ D+  TL  +  +        ++L ++LLA+   NP+
Sbjct: 689 PGHFQTLLQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPD 748

Query: 184 VGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQ---E 240
           +GYC+ L+ + A+ LLY  +EDAFW LV ++  E    + +++    T+ G Q  Q    
Sbjct: 749 IGYCQGLNRLVAVALLYLEQEDAFWCLVTIV--EVFMPRDYYTK---TLLGSQVDQRVFR 803

Query: 241 HVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300
            +++    +  GH ++  +          + + +D +   +  ++WD +L EG + +   
Sbjct: 804 DLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRF 863

Query: 301 TRIAFKVQQKRLTK 314
               FK +++ + K
Sbjct: 864 ALALFKYKEEEILK 877


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,686,815
Number of Sequences: 37866
Number of extensions: 1453630
Number of successful extensions: 8035
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 119
Number of HSP's successfully gapped in prelim test: 459
Number of HSP's that attempted gapping in prelim test: 6664
Number of HSP's gapped (non-prelim): 1532
length of query: 549
length of database: 18,247,518
effective HSP length: 107
effective length of query: 442
effective length of database: 14,195,856
effective search space: 6274568352
effective search space used: 6274568352
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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