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Search of human proteins with 149944548
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|149944548 neurobeachin-like 2 [Homo sapiens]
(2754 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|149944548 neurobeachin-like 2 [Homo sapiens] 5528 0.0
gi|224451124 neurobeachin-like 1 isoform 3 [Homo sapiens] 2304 0.0
gi|149944613 neurobeachin-like 1 isoform 1 [Homo sapiens] 1385 0.0
gi|154240744 neurobeachin-like 1 isoform 2 [Homo sapiens] 947 0.0
gi|62422577 neurobeachin [Homo sapiens] 468 e-131
gi|148233596 LPS-responsive vesicle trafficking, beach and ancho... 455 e-127
gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Ho... 395 e-109
gi|191252801 WDFY family member 4 [Homo sapiens] 334 6e-91
gi|31543297 neutral sphingomyelinase (N-SMase) activation associ... 304 7e-82
gi|221625547 neutral sphingomyelinase (N-SMase) activation assoc... 304 7e-82
gi|54292123 lysosomal trafficking regulator [Homo sapiens] 293 2e-78
gi|239756689 PREDICTED: WD repeat domain 81 [Homo sapiens] 107 2e-22
gi|239751186 PREDICTED: WD repeat domain 81 [Homo sapiens] 107 2e-22
gi|239745674 PREDICTED: WD repeat domain 81 [Homo sapiens] 107 2e-22
gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 56 4e-07
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap... 51 2e-05
gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens] 50 4e-05
gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens] 50 4e-05
gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens] 50 4e-05
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 50 4e-05
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 49 5e-05
gi|31657103 WD repeat domain 23 isoform 1 [Homo sapiens] 49 7e-05
gi|31657101 WD repeat domain 23 isoform 2 [Homo sapiens] 49 7e-05
gi|21536485 HIR histone cell cycle regulation defective homolog ... 49 7e-05
gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens] 49 9e-05
gi|22027541 programmed cell death 7 [Homo sapiens] 49 9e-05
gi|28872796 CCAAT/enhancer binding protein beta [Homo sapiens] 47 2e-04
gi|110556644 zinc finger protein, multitype 1 [Homo sapiens] 47 3e-04
gi|32189425 WD repeat domain 69 [Homo sapiens] 47 3e-04
gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens] 47 3e-04
>gi|149944548 neurobeachin-like 2 [Homo sapiens]
Length = 2754
Score = 5528 bits (14341), Expect = 0.0
Identities = 2754/2754 (100%), Positives = 2754/2754 (100%)
Query: 1 MAASERLYELWLLYYAQKDLGYLQQWLKAFVGAFKKSISLSSLEPRRPEEAGAEVPLLPL 60
MAASERLYELWLLYYAQKDLGYLQQWLKAFVGAFKKSISLSSLEPRRPEEAGAEVPLLPL
Sbjct: 1 MAASERLYELWLLYYAQKDLGYLQQWLKAFVGAFKKSISLSSLEPRRPEEAGAEVPLLPL 60
Query: 61 DELHVLAEQLHQADLEQALLLLKLFIILCRNLENIEAGRGQVLVPRVLALLTKLVAELKG 120
DELHVLAEQLHQADLEQALLLLKLFIILCRNLENIEAGRGQVLVPRVLALLTKLVAELKG
Sbjct: 61 DELHVLAEQLHQADLEQALLLLKLFIILCRNLENIEAGRGQVLVPRVLALLTKLVAELKG 120
Query: 121 CPPPQGRGTQLENVALHALLLCEGLFDPYQTWRRQRSGEVISSKEKSKYKFPPAALPQEF 180
CPPPQGRGTQLENVALHALLLCEGLFDPYQTWRRQRSGEVISSKEKSKYKFPPAALPQEF
Sbjct: 121 CPPPQGRGTQLENVALHALLLCEGLFDPYQTWRRQRSGEVISSKEKSKYKFPPAALPQEF 180
Query: 181 SAFFQESLQNADHLPPILLLRLIHLFCAVLAGGKENGQMAVSDGSVKGLLSVVRGWSRGP 240
SAFFQESLQNADHLPPILLLRLIHLFCAVLAGGKENGQMAVSDGSVKGLLSVVRGWSRGP
Sbjct: 181 SAFFQESLQNADHLPPILLLRLIHLFCAVLAGGKENGQMAVSDGSVKGLLSVVRGWSRGP 240
Query: 241 APDPCLVPLALEALVGAVHVLHASRAPPRGPELRALLESYFHVLNADWPAGLSSGPEEAL 300
APDPCLVPLALEALVGAVHVLHASRAPPRGPELRALLESYFHVLNADWPAGLSSGPEEAL
Sbjct: 241 APDPCLVPLALEALVGAVHVLHASRAPPRGPELRALLESYFHVLNADWPAGLSSGPEEAL 300
Query: 301 VTLRVSMLDAIPMMLACEDRPVLQATFLSNNCFEHLTRLIQNSKLYLQSRAPPEGDSDLA 360
VTLRVSMLDAIPMMLACEDRPVLQATFLSNNCFEHLTRLIQNSKLYLQSRAPPEGDSDLA
Sbjct: 301 VTLRVSMLDAIPMMLACEDRPVLQATFLSNNCFEHLTRLIQNSKLYLQSRAPPEGDSDLA 360
Query: 361 TRLLTEPDVQKVLDQDTDAIAVHVVRVLTCIMSDSPSAKEVFKERIGYPHLQEVLQSHGP 420
TRLLTEPDVQKVLDQDTDAIAVHVVRVLTCIMSDSPSAKEVFKERIGYPHLQEVLQSHGP
Sbjct: 361 TRLLTEPDVQKVLDQDTDAIAVHVVRVLTCIMSDSPSAKEVFKERIGYPHLQEVLQSHGP 420
Query: 421 PTHRLLQELLNMAVEGDHSMCPPPPIRNEQPVLVLAQWLPSLPTAELRLFLAQRLRWLCD 480
PTHRLLQELLNMAVEGDHSMCPPPPIRNEQPVLVLAQWLPSLPTAELRLFLAQRLRWLCD
Sbjct: 421 PTHRLLQELLNMAVEGDHSMCPPPPIRNEQPVLVLAQWLPSLPTAELRLFLAQRLRWLCD 480
Query: 481 SCPASRATCVQAGLVGCLLETLSTGLALEARCQEQLLALLQALGRVSIRPMELRHLLRPR 540
SCPASRATCVQAGLVGCLLETLSTGLALEARCQEQLLALLQALGRVSIRPMELRHLLRPR
Sbjct: 481 SCPASRATCVQAGLVGCLLETLSTGLALEARCQEQLLALLQALGRVSIRPMELRHLLRPR 540
Query: 541 PGLDSEPGGAEAGKARHAGAVIRTLSGMARHQGPARALRYFDLTPSMAGIMVPPVQRWPG 600
PGLDSEPGGAEAGKARHAGAVIRTLSGMARHQGPARALRYFDLTPSMAGIMVPPVQRWPG
Sbjct: 541 PGLDSEPGGAEAGKARHAGAVIRTLSGMARHQGPARALRYFDLTPSMAGIMVPPVQRWPG 600
Query: 601 PGFTFHAWLCLHPMDTAPTPAPTRPLQRKQLYSFFTSSGSGFEAFFTAAGTLVVAVCTRK 660
PGFTFHAWLCLHPMDTAPTPAPTRPLQRKQLYSFFTSSGSGFEAFFTAAGTLVVAVCTRK
Sbjct: 601 PGFTFHAWLCLHPMDTAPTPAPTRPLQRKQLYSFFTSSGSGFEAFFTAAGTLVVAVCTRK 660
Query: 661 EYLTMSLPEVSFADSAWHCVAIVHVPGRRPFSQNLVHVYKDGHLVKTAPLRCPSLSEPFS 720
EYLTMSLPEVSFADSAWHCVAIVHVPGRRPFSQNLVHVYKDGHLVKTAPLRCPSLSEPFS
Sbjct: 661 EYLTMSLPEVSFADSAWHCVAIVHVPGRRPFSQNLVHVYKDGHLVKTAPLRCPSLSEPFS 720
Query: 721 SCCIGSAGYRTTTTTTGLPTPPVPATLAYTHPALTRSQSVPASTGLGWGSGLVAPLQEGS 780
SCCIGSAGYRTTTTTTGLPTPPVPATLAYTHPALTRSQSVPASTGLGWGSGLVAPLQEGS
Sbjct: 721 SCCIGSAGYRTTTTTTGLPTPPVPATLAYTHPALTRSQSVPASTGLGWGSGLVAPLQEGS 780
Query: 781 IDSTLAGTQDTRWGSPTSLEGELGAVAIFHEALQATALRTLCTLGPNETAPFKPEGELHE 840
IDSTLAGTQDTRWGSPTSLEGELGAVAIFHEALQATALRTLCTLGPNETAPFKPEGELHE
Sbjct: 781 IDSTLAGTQDTRWGSPTSLEGELGAVAIFHEALQATALRTLCTLGPNETAPFKPEGELHE 840
Query: 841 LSTRLLLHYSPQACKNNICLDLSPSHGLDGRLTGHRVETWDVKDVVNCVGGMGALLPLLE 900
LSTRLLLHYSPQACKNNICLDLSPSHGLDGRLTGHRVETWDVKDVVNCVGGMGALLPLLE
Sbjct: 841 LSTRLLLHYSPQACKNNICLDLSPSHGLDGRLTGHRVETWDVKDVVNCVGGMGALLPLLE 900
Query: 901 RVAAQPKEAEAGPAETHDLVGPELTSGHNTQGLVLPLGKSSEERMERNAVAAFLLMLRNF 960
RVAAQPKEAEAGPAETHDLVGPELTSGHNTQGLVLPLGKSSEERMERNAVAAFLLMLRNF
Sbjct: 901 RVAAQPKEAEAGPAETHDLVGPELTSGHNTQGLVLPLGKSSEERMERNAVAAFLLMLRNF 960
Query: 961 LQGHMVNQESLVQCQGPAIIGALLRKVPSWAMDMNVLMSAQLLMEQVAAEGSGPLLYLLY 1020
LQGHMVNQESLVQCQGPAIIGALLRKVPSWAMDMNVLMSAQLLMEQVAAEGSGPLLYLLY
Sbjct: 961 LQGHMVNQESLVQCQGPAIIGALLRKVPSWAMDMNVLMSAQLLMEQVAAEGSGPLLYLLY 1020
Query: 1021 QHLLFNFHLWTLSDFAVRLGHIQYMSSIVREHRQKLRKKYGVQFILDALRTHYSPQRERP 1080
QHLLFNFHLWTLSDFAVRLGHIQYMSSIVREHRQKLRKKYGVQFILDALRTHYSPQRERP
Sbjct: 1021 QHLLFNFHLWTLSDFAVRLGHIQYMSSIVREHRQKLRKKYGVQFILDALRTHYSPQRERP 1080
Query: 1081 LAADDLRTVQTSLLGLAREFLVRSLSADDVQVTQTMLSFLAATGDDGQAVGALDLLLALL 1140
LAADDLRTVQTSLLGLAREFLVRSLSADDVQVTQTMLSFLAATGDDGQAVGALDLLLALL
Sbjct: 1081 LAADDLRTVQTSLLGLAREFLVRSLSADDVQVTQTMLSFLAATGDDGQAVGALDLLLALL 1140
Query: 1141 HGSLVQESLAVFLLEPGNLEVLLALLVRPGSLPLLPDRVCKILRRLQQNERLPERSRQRL 1200
HGSLVQESLAVFLLEPGNLEVLLALLVRPGSLPLLPDRVCKILRRLQQNERLPERSRQRL
Sbjct: 1141 HGSLVQESLAVFLLEPGNLEVLLALLVRPGSLPLLPDRVCKILRRLQQNERLPERSRQRL 1200
Query: 1201 RLRECGLQGLVACLPEGTVSPQLCQGLYKLFLGADCLNLSDLLAVVQLSLQADLSVRLDI 1260
RLRECGLQGLVACLPEGTVSPQLCQGLYKLFLGADCLNLSDLLAVVQLSLQADLSVRLDI
Sbjct: 1201 RLRECGLQGLVACLPEGTVSPQLCQGLYKLFLGADCLNLSDLLAVVQLSLQADLSVRLDI 1260
Query: 1261 CRQLFHLIYGQPDVVRLLARQAGWQDVLTRLYVLEAATAGSPPPSSPESPTSPKPAPPKP 1320
CRQLFHLIYGQPDVVRLLARQAGWQDVLTRLYVLEAATAGSPPPSSPESPTSPKPAPPKP
Sbjct: 1261 CRQLFHLIYGQPDVVRLLARQAGWQDVLTRLYVLEAATAGSPPPSSPESPTSPKPAPPKP 1320
Query: 1321 PTESPAEPSDVFLPSEAPCPDPDGFYHALSPFCTPFDLGLERSSVGSGNTAGGGGSSGTL 1380
PTESPAEPSDVFLPSEAPCPDPDGFYHALSPFCTPFDLGLERSSVGSGNTAGGGGSSGTL
Sbjct: 1321 PTESPAEPSDVFLPSEAPCPDPDGFYHALSPFCTPFDLGLERSSVGSGNTAGGGGSSGTL 1380
Query: 1381 TPASQPGTPSPLDGPRPFPAAPGRHSSSLSNVLEDGSLPEPTISGDDTSNTSNPQQTSEE 1440
TPASQPGTPSPLDGPRPFPAAPGRHSSSLSNVLEDGSLPEPTISGDDTSNTSNPQQTSEE
Sbjct: 1381 TPASQPGTPSPLDGPRPFPAAPGRHSSSLSNVLEDGSLPEPTISGDDTSNTSNPQQTSEE 1440
Query: 1441 ELCNLLTNVLFSVTWRGVEGSDEAAWRERGQVFSVLTQLGASATLVRPPDCIKRSLLEMM 1500
ELCNLLTNVLFSVTWRGVEGSDEAAWRERGQVFSVLTQLGASATLVRPPDCIKRSLLEMM
Sbjct: 1441 ELCNLLTNVLFSVTWRGVEGSDEAAWRERGQVFSVLTQLGASATLVRPPDCIKRSLLEMM 1500
Query: 1501 LESALTDIKEAPVGVLASLTQQALWLLRLLQDFLCAEGHGNQELWSEKLFEGVCSLLDRL 1560
LESALTDIKEAPVGVLASLTQQALWLLRLLQDFLCAEGHGNQELWSEKLFEGVCSLLDRL
Sbjct: 1501 LESALTDIKEAPVGVLASLTQQALWLLRLLQDFLCAEGHGNQELWSEKLFEGVCSLLDRL 1560
Query: 1561 GAWPHLANGTADLREMAQIGLRLVLGYILLEDPQLHAQAYVRLHMLLQTAVPARREEACY 1620
GAWPHLANGTADLREMAQIGLRLVLGYILLEDPQLHAQAYVRLHMLLQTAVPARREEACY
Sbjct: 1561 GAWPHLANGTADLREMAQIGLRLVLGYILLEDPQLHAQAYVRLHMLLQTAVPARREEACY 1620
Query: 1621 VLSKLEAALGRVLNTSSLESATDEAGSPLAAAAAAAAAERCSWLVPLVRTLLDRAYEPLG 1680
VLSKLEAALGRVLNTSSLESATDEAGSPLAAAAAAAAAERCSWLVPLVRTLLDRAYEPLG
Sbjct: 1621 VLSKLEAALGRVLNTSSLESATDEAGSPLAAAAAAAAAERCSWLVPLVRTLLDRAYEPLG 1680
Query: 1681 LQWGLPSLPPTNGSPTFFEDFQAFCATPEWRHFIDKQVQPTMSQFEMDTYAKSHDLMSGF 1740
LQWGLPSLPPTNGSPTFFEDFQAFCATPEWRHFIDKQVQPTMSQFEMDTYAKSHDLMSGF
Sbjct: 1681 LQWGLPSLPPTNGSPTFFEDFQAFCATPEWRHFIDKQVQPTMSQFEMDTYAKSHDLMSGF 1740
Query: 1741 WNACYDMLMSSGQRRQWERAQSRRAFQELVLEPAQRRARLEGLRYTAVLKQQATQHSMAL 1800
WNACYDMLMSSGQRRQWERAQSRRAFQELVLEPAQRRARLEGLRYTAVLKQQATQHSMAL
Sbjct: 1741 WNACYDMLMSSGQRRQWERAQSRRAFQELVLEPAQRRARLEGLRYTAVLKQQATQHSMAL 1800
Query: 1801 LHWGALWRQLASPCGAWALRDTPIPRWKLSSAETYSRMRLKLVPNHHFDPHLEASALRDN 1860
LHWGALWRQLASPCGAWALRDTPIPRWKLSSAETYSRMRLKLVPNHHFDPHLEASALRDN
Sbjct: 1801 LHWGALWRQLASPCGAWALRDTPIPRWKLSSAETYSRMRLKLVPNHHFDPHLEASALRDN 1860
Query: 1861 LGEVPLTPTEEASLPLAVTKEAKVSTPPELLQEDQLGEDELAELETPMEAAELDEQREKL 1920
LGEVPLTPTEEASLPLAVTKEAKVSTPPELLQEDQLGEDELAELETPMEAAELDEQREKL
Sbjct: 1861 LGEVPLTPTEEASLPLAVTKEAKVSTPPELLQEDQLGEDELAELETPMEAAELDEQREKL 1920
Query: 1921 VLSAECQLVTVVAVVPGLLEVTTQNVYFYDGSTERVETEEGIGYDFRRPLAQLREVHLRR 1980
VLSAECQLVTVVAVVPGLLEVTTQNVYFYDGSTERVETEEGIGYDFRRPLAQLREVHLRR
Sbjct: 1921 VLSAECQLVTVVAVVPGLLEVTTQNVYFYDGSTERVETEEGIGYDFRRPLAQLREVHLRR 1980
Query: 1981 FNLRRSALELFFIDQANYFLNFPCKVGTTPVSSPSQTPRPQPGPIPPHTQVRNQVYSWLL 2040
FNLRRSALELFFIDQANYFLNFPCKVGTTPVSSPSQTPRPQPGPIPPHTQVRNQVYSWLL
Sbjct: 1981 FNLRRSALELFFIDQANYFLNFPCKVGTTPVSSPSQTPRPQPGPIPPHTQVRNQVYSWLL 2040
Query: 2041 RLRPPSQGYLSSRSPQEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFP 2100
RLRPPSQGYLSSRSPQEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFP
Sbjct: 2041 RLRPPSQGYLSSRSPQEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFP 2100
Query: 2101 WVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGTHY 2160
WVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGTHY
Sbjct: 2101 WVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGTHY 2160
Query: 2161 SNAAGVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVKELIPEFF 2220
SNAAGVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVKELIPEFF
Sbjct: 2161 SNAAGVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVKELIPEFF 2220
Query: 2221 YFPDFLENQNGFDLGCLQLTNEKVGDVVLPPWASSPEDFIQQHRQALESEYVSAHLHEWI 2280
YFPDFLENQNGFDLGCLQLTNEKVGDVVLPPWASSPEDFIQQHRQALESEYVSAHLHEWI
Sbjct: 2221 YFPDFLENQNGFDLGCLQLTNEKVGDVVLPPWASSPEDFIQQHRQALESEYVSAHLHEWI 2280
Query: 2281 DLIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVTDERERKALEGIISNFGQTPCQLLKE 2340
DLIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVTDERERKALEGIISNFGQTPCQLLKE
Sbjct: 2281 DLIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVTDERERKALEGIISNFGQTPCQLLKE 2340
Query: 2341 PHPTRLSAEEAAHRLARLDTNSPSIFQHLDELKAFFAEVVSDGVPLVLALVPHRQPHSFI 2400
PHPTRLSAEEAAHRLARLDTNSPSIFQHLDELKAFFAEVVSDGVPLVLALVPHRQPHSFI
Sbjct: 2341 PHPTRLSAEEAAHRLARLDTNSPSIFQHLDELKAFFAEVVSDGVPLVLALVPHRQPHSFI 2400
Query: 2401 TQGSPDLLVTVSASGLLGTHSWLPYDRNISNYFSFSKDPTMGSHKTQRLLSGPWVPGSGV 2460
TQGSPDLLVTVSASGLLGTHSWLPYDRNISNYFSFSKDPTMGSHKTQRLLSGPWVPGSGV
Sbjct: 2401 TQGSPDLLVTVSASGLLGTHSWLPYDRNISNYFSFSKDPTMGSHKTQRLLSGPWVPGSGV 2460
Query: 2461 SGQALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISG 2520
SGQALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISG
Sbjct: 2461 SGQALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISG 2520
Query: 2521 SRDTTCMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVIIH 2580
SRDTTCMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVIIH
Sbjct: 2521 SRDTTCMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVIIH 2580
Query: 2581 TVRRGQFVAALRPLGATFPGPIFHLALGSEGQIVVQSSAWERPGAQVTYSLHLYSVNGKL 2640
TVRRGQFVAALRPLGATFPGPIFHLALGSEGQIVVQSSAWERPGAQVTYSLHLYSVNGKL
Sbjct: 2581 TVRRGQFVAALRPLGATFPGPIFHLALGSEGQIVVQSSAWERPGAQVTYSLHLYSVNGKL 2640
Query: 2641 RASLPLAEQPTALTVTEDFVLLGTAQCALHILQLNTLLPAAPPLPMKVAIRSVAVTKERS 2700
RASLPLAEQPTALTVTEDFVLLGTAQCALHILQLNTLLPAAPPLPMKVAIRSVAVTKERS
Sbjct: 2641 RASLPLAEQPTALTVTEDFVLLGTAQCALHILQLNTLLPAAPPLPMKVAIRSVAVTKERS 2700
Query: 2701 HVLVGLEDGKLIVVVAGQPSEVRSSQFARKLWRSSRRISQVSSGETEYNPTEAR 2754
HVLVGLEDGKLIVVVAGQPSEVRSSQFARKLWRSSRRISQVSSGETEYNPTEAR
Sbjct: 2701 HVLVGLEDGKLIVVVAGQPSEVRSSQFARKLWRSSRRISQVSSGETEYNPTEAR 2754
>gi|224451124 neurobeachin-like 1 isoform 3 [Homo sapiens]
Length = 2694
Score = 2304 bits (5970), Expect = 0.0
Identities = 1286/2829 (45%), Positives = 1785/2829 (63%), Gaps = 210/2829 (7%)
Query: 1 MAASERLYELWLLYYAQKDLGYLQQWLKAFVGAFKKSISLSSLE-PRRPEEAGAEVPLLP 59
MA+ ERL+ELW+LY +KD YL+ WL FV ++++ + + + P R ++ + LLP
Sbjct: 1 MASRERLFELWMLYCTKKDPDYLKLWLDTFVSSYEQFLDVDFEKLPTRVDDMPPGISLLP 60
Query: 60 LDELHVLAEQLHQA---------DLEQAL--LLLKLFIILCRNLENIEAGRGQVLVPRVL 108
+ L VL QL Q + +QAL LL+K FIILCRNL N+E + V+
Sbjct: 61 DNILQVLRIQLLQCVQKMADGLEEQQQALSILLVKFFIILCRNLSNVEEIGTCSYINYVI 120
Query: 109 ALLTKLVAELKGCPPPQGRGTQ--LENVALHALLLCEGLFDPYQTWRRQRSGEVISSKEK 166
+ T + +LK + Q +E +HAL CE L+DPY+ WR + SG ++S+ EK
Sbjct: 121 TMTTLYIQQLKSKKKEKEMADQTCIEEFVIHALAFCESLYDPYRNWRHRISGRILSTVEK 180
Query: 167 SKYKFPPAALPQEFSAFFQESLQNADHLPPILLLRLIHLFCAVLAGGKENGQMAVSDGSV 226
S+ K+ PA+L EF FF + Q ++HL L L+HLF A++AGG+ N A+S ++
Sbjct: 181 SRQKYKPASLTVEFVPFFYQCFQESEHLKESLKCCLLHLFGAIVAGGQRNALQAISPATM 240
Query: 227 KGLLSVVRGWSRGPAPDPCLV----PLALEALVGAVHVLHASRAPPRGPELRALLESYFH 282
+ L+ V+ DP V L L+ L VH+L +S + R E +LE+YF
Sbjct: 241 EVLMRVLADCDSWEDGDPEEVGRKAELTLKCLTEVVHILLSSNSDQRQVETSTILENYFK 300
Query: 283 VLNADWPA----GLSSGPEEALVTLRVSMLDAIPMMLACEDRPVLQATFLSNNCFEHLTR 338
+LN+D A S E + L++ ML+ I ML C DRPVLQA FL++NCFEHL R
Sbjct: 301 LLNSDHSALPNQRRSRQWENRFIALQIKMLNTITAMLDCTDRPVLQAIFLNSNCFEHLIR 360
Query: 339 LIQNSKLYLQSRAPPEGDSDLATRLLTEPDVQKVLDQDTDAIAVHVVRVLTCIMSDSPSA 398
L+QN K++ D +A+ ++ LT +M+ SP+A
Sbjct: 361 LLQNCKVF---------------------------QGQLDCLAISTIQALTAVMNKSPAA 393
Query: 399 KEVFKERIGYPHLQEVLQSHGPPTHRLLQELLNMAVEGDHSMCPPPPIRNEQPVLVLAQW 458
KEVFKERIGY H+ EVL+S G P LL+EL+NMAVEGDH+ I N QP+L+L QW
Sbjct: 394 KEVFKERIGYTHMLEVLKSLGQPPLELLKELMNMAVEGDHTSVGILGISNVQPLLLLIQW 453
Query: 459 LPSLPTAELRLFLAQRLRWLCDSCPASRATCVQAGLVGCLLETLSTGLALEARCQEQLLA 518
LP L + +L++F++ L+ +C SR TCV A + ++ETL +L C E L+A
Sbjct: 454 LPELQSHDLQIFISDWLKRICCINRQSRTTCVNANMGIRIIETLDLHSSLHQTCAENLIA 513
Query: 519 LLQALGRVSIRPMELRHLLRPRPGLDSEPGGAEAGKARHAGAVIRTLSGMARHQGPARAL 578
+ +LG S+ E+R LLR +SE + V R + MAR AL
Sbjct: 514 IHGSLGSQSVSSEEIRRLLRLLRVDESE------SVHPYVTPVTRAILTMARKLSLESAL 567
Query: 579 RYFDLTPSMAGIMVPPVQRWPGPGFTFHAWLCLHPMDTAPTPAPTRPLQRKQLYSFFTSS 638
+YF+L+ SMAGI VPP+Q+WPG F+F AW CL D + +RKQLYSFFT S
Sbjct: 568 QYFNLSHSMAGISVPPIQKWPGSAFSFSAWFCLD-QDQLTLGIANKGGKRKQLYSFFTGS 626
Query: 639 GSGFEAFFTAAGTLVVAVCTRKEYLTMSLPEVSFADSAWHCVAIVHVPGRRPFSQNLVHV 698
G GFEAF T +G LVVAVCT++EY T+ LP+ SF DS WH + +VH+PG+RPF Q+ V++
Sbjct: 627 GMGFEAFITHSGMLVVAVCTKREYATVMLPDHSFCDSLWHNITVVHMPGKRPFGQSFVYI 686
Query: 699 YKDGHLVKTAPLRCPSLSEPFSSCCIGSAGYRTTTTTTG-LPTPPVPATLAYTHPALTRS 757
Y +G +APLR P+++EPF+SCCIGSAG RTTT +P PP + + P T
Sbjct: 687 YDNGQQKVSAPLRFPAMNEPFTSCCIGSAGQRTTTPPPSQIPDPPFSSPIT---PHRTSF 743
Query: 758 QSVPASTGLGWGSGLVAPLQEGSIDSTL--AGTQDTRWGSPTSLEGELGAVAIFHEALQA 815
+ +S WG +++ + + L AGTQD+ WG PTSLEG+LG+V IF+E LQ
Sbjct: 744 GGILSSAS--WGG----TIEKSKLITKLISAGTQDSEWGCPTSLEGQLGSVIIFYEPLQP 797
Query: 816 TALRTLCTLGPNETAPFK-PEGELHELSTRLLLHYSPQACKNNICLDLSPSHGLDGRLTG 874
++ L GPN +P+K E ++ +L +LL+Y+ +ACKN+ICLDLS ++ L GRLTG
Sbjct: 798 PQVKALYLAGPNCLSPWKCQESDMADLPGNILLYYTAKACKNSICLDLS-TNCLHGRLTG 856
Query: 875 HRVETWDVKDVVNCVGGMGALLPLLERVAAQPKEAEAGPAETHDLVGPELTSGHNTQGLV 934
++V WD+KD++NC+GG+ L PLLE+++ E + P E ++ PE + LV
Sbjct: 857 NKVVNWDIKDIINCIGGLNVLFPLLEQIS-HFSEGQI-PEEKNESTVPESVTPVEGDWLV 914
Query: 935 LPLGKSSEERMERNAVAAFLLMLRNFLQGHMVNQESLVQCQGPAIIGALLRKVPSWAMDM 994
K+SE R+ERN VA F+L++++F+Q H +NQ +L+ G A +GALL+KVPS MD+
Sbjct: 915 WTSTKASESRLERNLVATFILIVKHFIQRHPINQGNLIHSHGVATLGALLQKVPSTLMDV 974
Query: 995 NVLMSAQLLMEQVAAEGSGPLLYLLYQHLLFNFHLWTLSDFAVRLGHIQYMSSIVREHRQ 1054
NVLM+ QLL+EQV+ E + LL +YQ+LLF+F +W DF R+GHIQY+S+I+++ R+
Sbjct: 975 NVLMAVQLLIEQVSLEKNMQLLQQMYQYLLFDFRIWNRGDFPFRIGHIQYLSTIIKDSRR 1034
Query: 1055 KLRKKYGVQFILDALRTHYSPQ-RERPLAADDLRTVQTSLLGLAREFLVRSLSADDVQVT 1113
RKKYGVQF+LD LR +Y + L+ DD+RT++TSL GL + FL + S +++Q
Sbjct: 1035 VFRKKYGVQFLLDTLRIYYGNGCKYNELSLDDIRTIRTSLYGLIKYFLCKGGSHEEIQ-- 1092
Query: 1114 QTMLSFLAATGDDGQAVGALDLLLALLHGSLVQESLAVFLLEPGNLEVLLALLVRPGSLP 1173
+++ ++AAT ++ Q G LD+L +LL S + L + L EPGN ++L ALL+
Sbjct: 1093 -SIMGYIAATNEEEQLFGILDVLFSLLRTSPTRGQLFLLLFEPGNADILYALLLNQKYSD 1151
Query: 1174 LLPDRVCKILRRLQQNERLPERSRQRLRLRECGLQGLVACLPEGTVSPQLCQGLYKLFLG 1233
L + + KI+ ++ + + ERS+Q +RLRE G GL L E V+ L + L +
Sbjct: 1152 RLREIIFKIMEQMLKCTNVYERSKQHIRLREVGYSGLGLLLNEALVNTSLIKNLTHQIIN 1211
Query: 1234 AD-CLNLSDLLAVVQLSLQADLSVRLDICRQLFHLIYGQPDVVRLLARQAGWQDVLTRLY 1292
D +N DLL+VV +S +A ++VR+ ICR++ ++ QPD +++Q GWQD L RL+
Sbjct: 1212 TDPVINFKDLLSVVYISHRAHINVRVAICRKVLQILQFQPDAAHQISQQVGWQDTLVRLF 1271
Query: 1293 V---------------------------LEAATAGSPPPSSPESPTSPKPAPPKPP---- 1321
+ E S + E TS A
Sbjct: 1272 LKAKFENGNTLHKHSRAVLMKDNDKNMSTEDTKKNSDEKTDEEKITSFASANVSSDQWSL 1331
Query: 1322 -------TESPAEPSDVFLPSEA-PCPDPDGFYHALSPFCTPFDLGLERSSVGSGNTAGG 1373
+ +P P D + + + + F+H+ P L L+ S + S +
Sbjct: 1332 EDRHSLDSNTPLFPEDSSVGELSFKSENQEEFWHS-----NPSHLSLDLSGIDSCEMS-- 1384
Query: 1374 GGSSGTLTPASQPGTPSPLDGPRPFPAAPGRHSSSLSNVLEDGSLPEPTISGDDTSNTSN 1433
SG+ P S P TPSP++ + F HS S++ D + D +
Sbjct: 1385 --DSGSQVPDSLPSTPSPVESTKSFSV----HSDRESSITND-------MGFSDDFSLLE 1431
Query: 1434 PQQTSEEELCNLLTNVLFSVTWRGVEGSDEAAWRERGQVFSVLTQLGASATLVRPPDCIK 1493
Q+ EEEL LLT++L V +G+E SD+ W ERGQVFS L++ G S+ L+RP D IK
Sbjct: 1432 SQERCEEELLQLLTHILNYVMCKGLEKSDDDTWIERGQVFSALSKPGISSELLRPSDEIK 1491
Query: 1494 RSLLEMMLESALTDIKEAPVGVLASLTQQALWLLRLLQDFLCAEGHGNQELWSEKLFEGV 1553
+LL+ MLE A+++ +EA + + + A L+ ++QDFL +EG N +W+EKL E +
Sbjct: 1492 LTLLQKMLEWAISENREAKTNPVTA--ENAFRLVLIIQDFLQSEGLVNSNMWTEKLLEDM 1549
Query: 1554 CSLLDRLGAWPHLANGTADLREMAQIGLRLVLGYILLEDPQLHAQAYVRLHMLLQTAVPA 1613
L D L + + +++QI ++L+LG+I + Q+ A A +L+ LLQT V
Sbjct: 1550 MLLFDCLSV---CYSESPVWVKLSQIQIQLLLGFIGRGNLQVCAMASAKLNTLLQTKVIE 1606
Query: 1614 RREEACYVLSKLEAALGRVLNTSSLESATDEAGSPLAAAAAAAAAERCSWLVPLVRTLLD 1673
++EACY+L KLE L + + + E S+L+PLVRTL+
Sbjct: 1607 NQDEACYILGKLEHVLSQSIKEQT---------------------EIYSFLIPLVRTLVS 1645
Query: 1674 RAYEPLGLQWGLPSLPPTNGSPTFFEDFQAFCATPEWRHFIDKQVQPTMSQFEMDTYAKS 1733
+ YE L + LPSLP TNGS +FFEDFQ +C + EW+ +I+K + P M Q+E T+
Sbjct: 1646 KIYELLFMNLHLPSLPFTNGSSSFFEDFQEYCNSNEWQVYIEKYIVPYMKQYEAHTFYDG 1705
Query: 1734 HDLMSGFWNACYDMLMSSGQRRQWERAQSRRAFQELVLEPAQRRARLEGLRYTAVLKQQA 1793
H+ M+ +W CY+ LM + +R E +S+ FQEL +EP R+AR E LRY +LKQ +
Sbjct: 1706 HENMALYWKDCYEALMVNMHKRDREGGESKLKFQELFVEPFNRKARQENLRYNNMLKQLS 1765
Query: 1794 TQHSMALLHWGALWRQLASPCGAWALRDTPIPRWKLSSAETYSRMRLKLVPNHHFDPHLE 1853
+Q L W A+ L G WA R WKL++ E YSRMRLKLVPN++F H E
Sbjct: 1766 SQQLATLRRWKAIQLYLTCERGPWAKRKQNPIHWKLANVENYSRMRLKLVPNYNFKTHEE 1825
Query: 1854 ASALRDNLGEVPLTPTEEASLPLAVTKEAKVSTPPELLQEDQLG---EDELAELETPMEA 1910
ASALRDNLG P+ + L L V K+ KVS + ED+L ED A + ++
Sbjct: 1826 ASALRDNLGIQHSQPSSDTLL-LEVVKQVKVSD----MVEDKLDLPEEDITARVN--VDE 1878
Query: 1911 AELDEQREKLVLSAECQLVTVVAVVPGLLEVTTQNVYFYDGSTERVETEEGIGYDFRRPL 1970
E +Q+EKLVL +C+L+T++ V+PG LE+TTQ++YFYDGS +E E+G+G+DF+ P
Sbjct: 1879 KEEQDQKEKLVLMEDCELITIIDVIPGRLEITTQHIYFYDGS---IEKEDGVGFDFKWPH 1935
Query: 1971 AQLREVHLRRFNLRRSALELFFIDQANYFLNFPCKVGTTPVSSPSQTPRPQPGPIPPHTQ 2030
+Q+RE+HLRR+NLRRSALE+F +DQ+NYFLNF +
Sbjct: 1936 SQIREIHLRRYNLRRSALEIFHVDQSNYFLNFK-------------------------KE 1970
Query: 2031 VRNQVYSWLLRLRPPSQGYLSSRSPQEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTY 2090
VRN++YS LL L P+ Y SRSPQE+ +ASGLTQKWV REISNF+YL+Q+NT+AGRTY
Sbjct: 1971 VRNKIYSRLLSLHSPNS-YYGSRSPQELFKASGLTQKWVNREISNFDYLIQINTMAGRTY 2029
Query: 2091 NDLSQYPVFPWVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGT 2150
NDL+QYPVFPW+LQDY S LDL+NPAVFRDLSKPIGVVN K+A+ +REKYE+FEDP GT
Sbjct: 2030 NDLAQYPVFPWILQDYTSEELDLNNPAVFRDLSKPIGVVNEKNAKAMREKYENFEDPMGT 2089
Query: 2151 IDKFHYGTHYSNAAGVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAWQARLESPA 2210
IDKFHYGTHYSN+AGVMHYLIRVEPFT+LH+QLQSGRFDC+DRQFHS+ A WQA +++P
Sbjct: 2090 IDKFHYGTHYSNSAGVMHYLIRVEPFTTLHIQLQSGRFDCADRQFHSIPATWQALMDNPY 2149
Query: 2211 DVKELIPEFFYFPDFLENQNGFDLGCLQLTNEKVGDVVLPPWASSPEDFIQQHRQALESE 2270
DVKELIPEFFYFP+FLENQN F+LG LQ++ E V DV+LP WA S EDFI +HR+ALESE
Sbjct: 2150 DVKELIPEFFYFPEFLENQNQFNLGRLQISKELVNDVILPKWAKSAEDFIYKHRKALESE 2209
Query: 2271 YVSAHLHEWIDLIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVTDERERKALEGIISNF 2330
YVSAHLHEWIDLIFGYKQRGPAA EALNVFYYC+YEGAVDLD +TDE+ERKALEG+I+NF
Sbjct: 2210 YVSAHLHEWIDLIFGYKQRGPAAVEALNVFYYCSYEGAVDLDALTDEKERKALEGMINNF 2269
Query: 2331 GQTPCQLLKEPHPTRLSAEEAAHRLARLDTNSPSIFQHLDELKAFFAEVVSDGVPLVLAL 2390
GQTPCQLLKEPHP RLSAEEA + ++DT++ ++FQHL ELK+FF E +SDG+PL+ A
Sbjct: 2270 GQTPCQLLKEPHPPRLSAEEAVQKPTKIDTSTLNLFQHLPELKSFFIEGISDGIPLLKAT 2329
Query: 2391 VPHRQPHSFITQGSPDLLVTVSASGLLGTHSWLPYDRNISNYFSFSKDPTMGSHKTQRLL 2450
+P Q SF++QGSP+LL+T+S + ++GTH WLPYDRNISNYF+F KD T+ + KTQR +
Sbjct: 2330 IPKNQYRSFMSQGSPELLITISMNYVIGTHGWLPYDRNISNYFTFIKDQTVTNPKTQRSI 2389
Query: 2451 SGPWVPGSGVSGQALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLAL 2510
+G + PG ++ + V+ D KLLFS G+WD S++V +L +GK++S + H+D+VTCLA
Sbjct: 2390 NGSFAPGLEITSKLFVVSHDAKLLFSAGYWDNSIQVMSLTKGKIISHIIRHMDIVTCLAT 2449
Query: 2511 DTCGIYLISGSRDTTCMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVS 2570
D CGI+LISGSRDTTCM+W++ QGG+ VGLA KP Q+LYGH V V ISTELDMAVS
Sbjct: 2450 DYCGIHLISGSRDTTCMIWQITQQGGVPVGLASKPFQILYGHTNEVLSVGISTELDMAVS 2509
Query: 2571 GSEDGTVIIHTVRRGQFVAALRP-----LGATFPGPIFHLALGSEGQIVVQSSAWERPGA 2625
GS DGTVIIHT+++GQ++ LRP L T P +LA+ EG IVV SS E+
Sbjct: 2510 GSRDGTVIIHTIQKGQYMRTLRPPCESSLFLTIP----NLAISWEGHIVVYSSTEEKTTL 2565
Query: 2626 QVTYSLHLYSVNGKLRASLPLAEQPTALTVTEDFVLLGTAQCALHILQLNTLLPAAPPLP 2685
+ +LHL+S+NGK S L EQ + + + + ++ G+ Q L I L++L + PL
Sbjct: 2566 KDKNALHLFSINGKYLGSQILKEQVSDICIIGEHIVTGSIQGFLSIRDLHSLNLSINPLA 2625
Query: 2686 MKVAIRSVAVTKERSHVLVGLEDGKLIVVVAGQPSEVRSSQFARKLWRSSRRISQVSSGE 2745
M++ I V VTKE SH+LVGLEDGKLIVV G+P+E+RS Q +RK W SS+R+SQ+S+GE
Sbjct: 2626 MRLPIHCVCVTKEYSHILVGLEDGKLIVVGVGKPAEMRSGQLSRKFWGSSKRLSQISAGE 2685
Query: 2746 TEYNPTEAR 2754
TEYN +++
Sbjct: 2686 TEYNTQDSK 2694
>gi|149944613 neurobeachin-like 1 isoform 1 [Homo sapiens]
Length = 1404
Score = 1385 bits (3585), Expect = 0.0
Identities = 733/1418 (51%), Positives = 973/1418 (68%), Gaps = 94/1418 (6%)
Query: 1345 FYHALSPFCTPFDLGLERSSVGSGNTAGGGGSSGTLTPASQPGTPSPLDGPRPFPAAPGR 1404
F+H+ P L L+ S + S + SG+ P S P TPSP++ + F
Sbjct: 73 FWHS-----NPSHLSLDLSGIDSCEMS----DSGSQVPDSLPSTPSPVESTKSFSV---- 119
Query: 1405 HSSSLSNVLEDGSLPEPTISGDDTSNTSNPQQTSEEELCNLLTNVLFSVTWRGVEGSDEA 1464
HS S++ D + D + Q+ EEEL LLT++L V +G+E SD+
Sbjct: 120 HSDRESSITND-------MGFSDDFSLLESQERCEEELLQLLTHILNYVMCKGLEKSDDD 172
Query: 1465 AWRERGQVFSVLTQLGASATLVRPPDCIKRSLLEMMLESALTDIKEAPVGVLASLTQQAL 1524
W ERGQVFS L++ G S+ L+RP D IK +LL+ MLE A+++ +EA + + + A
Sbjct: 173 TWIERGQVFSALSKPGISSELLRPSDEIKLTLLQKMLEWAISENREAKTNPVTA--ENAF 230
Query: 1525 WLLRLLQDFLCAEGHGNQELWSEKLFEGVCSLLDRLGAWPHLANGTADLREMAQIGLRLV 1584
L+ ++QDFL +EG N +W+EKL E + L D L + + +++QI ++L+
Sbjct: 231 RLVLIIQDFLQSEGLVNSNMWTEKLLEDMMLLFDCLSV---CYSESPVWVKLSQIQIQLL 287
Query: 1585 LGYILLEDPQLHAQAYVRLHMLLQTAVPARREEACYVLSKLEAALGRVLNTSSLESATDE 1644
LG+I + Q+ A A +L+ LLQT V ++EACY+L KLE L + + +
Sbjct: 288 LGFIGRGNLQVCAMASAKLNTLLQTKVIENQDEACYILGKLEHVLSQSIKEQT------- 340
Query: 1645 AGSPLAAAAAAAAAERCSWLVPLVRTLLDRAYEPLGLQWGLPSLPPTNGSPTFFEDFQAF 1704
E S+L+PLVRTL+ + YE L + LPSLP TNGS +FFEDFQ +
Sbjct: 341 --------------EIYSFLIPLVRTLVSKIYELLFMNLHLPSLPFTNGSSSFFEDFQEY 386
Query: 1705 CATPEWRHFIDKQVQPTMSQFEMDTYAKSHDLMSGFWNACYDMLMSSGQRRQWERAQSRR 1764
C + EW+ +I+K + P M Q+E T+ H+ M+ +W CY+ LM + +R E +S+
Sbjct: 387 CNSNEWQVYIEKYIVPYMKQYEAHTFYDGHENMALYWKDCYEALMVNMHKRDREGGESKL 446
Query: 1765 AFQELVLEPAQRRARLEGLRYTAVLKQQATQHSMALLHWGALWRQLASPCGAWALRDTPI 1824
FQEL +EP R+AR E LRY +LKQ ++Q L W A+ L G WA R
Sbjct: 447 KFQELFVEPFNRKARQENLRYNNMLKQLSSQQLATLRRWKAIQLYLTCERGPWAKRKQNP 506
Query: 1825 PRWKLSSAETYSRMRLKLVPNHHFDPHLEASALRDNLGEVPLTPTEEASLPLAVTKEAKV 1884
WKL++ E YSRMRLKLVPN++F H EASALRDNLG P+ + L L V K+ KV
Sbjct: 507 IHWKLANVENYSRMRLKLVPNYNFKTHEEASALRDNLGIQHSQPSSDTLL-LEVVKQVKV 565
Query: 1885 STPPELLQEDQLG---EDELAELETPMEAAELDEQREKLVLSAECQLVTVVAVVPGLLEV 1941
S + ED+L ED A + ++ E +Q+EKLVL +C+L+T++ V+PG LE+
Sbjct: 566 SD----MVEDKLDLPEEDITARVN--VDEKEEQDQKEKLVLMEDCELITIIDVIPGRLEI 619
Query: 1942 TTQNVYFYDGSTERVETEEGIGYDFRRPLAQLREVHLRRFNLRRSALELFFIDQANYFLN 2001
TTQ++YFYDGS +E E+G+G+DF+ P +Q+RE+HLRR+NLRRSALE+F +DQ+NYFLN
Sbjct: 620 TTQHIYFYDGS---IEKEDGVGFDFKWPHSQIREIHLRRYNLRRSALEIFHVDQSNYFLN 676
Query: 2002 FPCKVGTTPVSSPSQTPRPQPGPIPPHTQVRNQVYSWLLRLRPPSQGYLSSRSPQEMLRA 2061
F +VRN++YS LL L P+ Y SRSPQE+ +A
Sbjct: 677 FK-------------------------KEVRNKIYSRLLSLHSPNS-YYGSRSPQELFKA 710
Query: 2062 SGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSNPAVFRD 2121
SGLTQKWV REISNF+YL+Q+NT+AGRTYNDL+QYPVFPW+LQDY S LDL+NPAVFRD
Sbjct: 711 SGLTQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEELDLNNPAVFRD 770
Query: 2122 LSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGTHYSNAAGVMHYLIRVEPFTSLHV 2181
LSKPIGVVN K+A+ +REKYE+FEDP GTIDKFHYGTHYSN+AGVMHYLIRVEPFT+LH+
Sbjct: 771 LSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMHYLIRVEPFTTLHI 830
Query: 2182 QLQSGRFDCSDRQFHSVAAAWQARLESPADVKELIPEFFYFPDFLENQNGFDLGCLQLTN 2241
QLQSGRFDC+DRQFHS+ A WQA +++P DVKELIPEFFYFP+FLENQN F+LG LQ++
Sbjct: 831 QLQSGRFDCADRQFHSIPATWQALMDNPYDVKELIPEFFYFPEFLENQNQFNLGRLQISK 890
Query: 2242 EKVGDVVLPPWASSPEDFIQQHRQALESEYVSAHLHEWIDLIFGYKQRGPAAEEALNVFY 2301
E V DV+LP WA S EDFI +HR+ALESEYVSAHLHEWIDLIFGYKQRGPAA EALNVFY
Sbjct: 891 ELVNDVILPKWAKSAEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRGPAAVEALNVFY 950
Query: 2302 YCTYEGAVDLDHVTDERERKALEGIISNFGQTPCQLLKEPHPTRLSAEEAAHRLARLDTN 2361
YC+YEGAVDLD +TDE+ERKALEG+I+NFGQTPCQLLKEPHP RLSAEEA + ++DT+
Sbjct: 951 YCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQLLKEPHPPRLSAEEAVQKPTKIDTS 1010
Query: 2362 SPSIFQHLDELKAFFAEVVSDGVPLVLALVPHRQPHSFITQGSPDLLVTVSASGLLGTHS 2421
+ ++FQHL ELK+FF E +SDG+PL+ A +P Q SF++QGSP+LL+T+S + ++GTH
Sbjct: 1011 TLNLFQHLPELKSFFIEGISDGIPLLKATIPKNQYRSFMSQGSPELLITISMNYVIGTHG 1070
Query: 2422 WLPYDRNISNYFSFSKDPTMGSHKTQRLLSGPWVPGSGVSGQALAVAPDGKLLFSGGHWD 2481
WLPYDRNISNYF+F KD T+ + KTQR ++G + PG ++ + V+ D KLLFS G+WD
Sbjct: 1071 WLPYDRNISNYFTFIKDQTVTNPKTQRSINGSFAPGLEITSKLFVVSHDAKLLFSAGYWD 1130
Query: 2482 GSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWRLLHQGGLSVGL 2541
S++V +L +GK++S + H+D+VTCLA D CGI+LISGSRDTTCM+W++ QGG+ VGL
Sbjct: 1131 NSIQVMSLTKGKIISHIIRHMDIVTCLATDYCGIHLISGSRDTTCMIWQITQQGGVPVGL 1190
Query: 2542 APKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQFVAALRP-----LGA 2596
A KP Q+LYGH V V ISTELDMAVSGS DGTVIIHT+++GQ++ LRP L
Sbjct: 1191 ASKPFQILYGHTNEVLSVGISTELDMAVSGSRDGTVIIHTIQKGQYMRTLRPPCESSLFL 1250
Query: 2597 TFPGPIFHLALGSEGQIVVQSSAWERPGAQVTYSLHLYSVNGKLRASLPLAEQPTALTVT 2656
T P +LA+ EG IVV SS E+ + +LHL+S+NGK S L EQ + + +
Sbjct: 1251 TIP----NLAISWEGHIVVYSSTEEKTTLKDKNALHLFSINGKYLGSQILKEQVSDICII 1306
Query: 2657 EDFVLLGTAQCALHILQLNTLLPAAPPLPMKVAIRSVAVTKERSHVLVGLEDGKLIVVVA 2716
+ ++ G+ Q L I L++L + PL M++ I V VTKE SH+LVGLEDGKLIVV
Sbjct: 1307 GEHIVTGSIQGFLSIRDLHSLNLSINPLAMRLPIHCVCVTKEYSHILVGLEDGKLIVVGV 1366
Query: 2717 GQPSEVRSSQFARKLWRSSRRISQVSSGETEYNPTEAR 2754
G+P+E+RS Q +RK W SS+R+SQ+S+GETEYN +++
Sbjct: 1367 GKPAEMRSGQLSRKFWGSSKRLSQISAGETEYNTQDSK 1404
>gi|154240744 neurobeachin-like 1 isoform 2 [Homo sapiens]
Length = 1335
Score = 947 bits (2448), Expect = 0.0
Identities = 512/998 (51%), Positives = 670/998 (67%), Gaps = 85/998 (8%)
Query: 1345 FYHALSPFCTPFDLGLERSSVGSGNTAGGGGSSGTLTPASQPGTPSPLDGPRPFPAAPGR 1404
F+H+ P L L+ S + S + SG+ P S P TPSP++ + F
Sbjct: 73 FWHS-----NPSHLSLDLSGIDSCEMS----DSGSQVPDSLPSTPSPVESTKSFSV---- 119
Query: 1405 HSSSLSNVLEDGSLPEPTISGDDTSNTSNPQQTSEEELCNLLTNVLFSVTWRGVEGSDEA 1464
HS S++ D + D + Q+ EEEL LLT++L V +G+E SD+
Sbjct: 120 HSDRESSITND-------MGFSDDFSLLESQERCEEELLQLLTHILNYVMCKGLEKSDDD 172
Query: 1465 AWRERGQVFSVLTQLGASATLVRPPDCIKRSLLEMMLESALTDIKEAPVGVLASLTQQAL 1524
W ERGQVFS L++ G S+ L+RP D IK +LL+ MLE A+++ +EA + + + A
Sbjct: 173 TWIERGQVFSALSKPGISSELLRPSDEIKLTLLQKMLEWAISENREAKTNPVTA--ENAF 230
Query: 1525 WLLRLLQDFLCAEGHGNQELWSEKLFEGVCSLLDRLGAWPHLANGTADLREMAQIGLRLV 1584
L+ ++QDFL +EG N +W+EKL E + L D L + + +++QI ++L+
Sbjct: 231 RLVLIIQDFLQSEGLVNSNMWTEKLLEDMMLLFDCLSV---CYSESPVWVKLSQIQIQLL 287
Query: 1585 LGYILLEDPQLHAQAYVRLHMLLQTAVPARREEACYVLSKLEAALGRVLNTSSLESATDE 1644
LG+I + Q+ A A +L+ LLQT V ++EACY+L KLE L + + +
Sbjct: 288 LGFIGRGNLQVCAMASAKLNTLLQTKVIENQDEACYILGKLEHVLSQSIKEQT------- 340
Query: 1645 AGSPLAAAAAAAAAERCSWLVPLVRTLLDRAYEPLGLQWGLPSLPPTNGSPTFFEDFQAF 1704
E S+L+PLVRTL+ + YE L + LPSLP TNGS +FFEDFQ +
Sbjct: 341 --------------EIYSFLIPLVRTLVSKIYELLFMNLHLPSLPFTNGSSSFFEDFQEY 386
Query: 1705 CATPEWRHFIDKQVQPTMSQFEMDTYAKSHDLMSGFWNACYDMLMSSGQRRQWERAQSRR 1764
C + EW+ +I+K + P M Q+E T+ H+ M+ +W CY+ LM + +R E +S+
Sbjct: 387 CNSNEWQVYIEKYIVPYMKQYEAHTFYDGHENMALYWKDCYEALMVNMHKRDREGGESKL 446
Query: 1765 AFQELVLEPAQRRARLEGLRYTAVLKQQATQHSMALLHWGALWRQLASPCGAWALRDTPI 1824
FQEL +EP R+AR E LRY +LKQ ++Q L W A+ L G WA R
Sbjct: 447 KFQELFVEPFNRKARQENLRYNNMLKQLSSQQLATLRRWKAIQLYLTCERGPWAKRKQNP 506
Query: 1825 PRWKLSSAETYSRMRLKLVPNHHFDPHLEASALRDNLGEVPLTPTEEASLPLAVTKEAKV 1884
WKL++ E YSRMRLKLVPN++F H EASALRDNLG P+ + L L V K+ KV
Sbjct: 507 IHWKLANVENYSRMRLKLVPNYNFKTHEEASALRDNLGIQHSQPSSDTLL-LEVVKQVKV 565
Query: 1885 STPPELLQEDQLG---EDELAELETPMEAAELDEQREKLVLSAECQLVTVVAVVPGLLEV 1941
S + ED+L ED A + ++ E +Q+EKLVL +C+L+T++ V+PG LE+
Sbjct: 566 SD----MVEDKLDLPEEDITARVN--VDEKEEQDQKEKLVLMEDCELITIIDVIPGRLEI 619
Query: 1942 TTQNVYFYDGSTERVETEEGIGYDFRRPLAQLREVHLRRFNLRRSALELFFIDQANYFLN 2001
TTQ++YFYDGS +E E+G+G+DF+ P +Q+RE+HLRR+NLRRSALE+F +DQ+NYFLN
Sbjct: 620 TTQHIYFYDGS---IEKEDGVGFDFKWPHSQIREIHLRRYNLRRSALEIFHVDQSNYFLN 676
Query: 2002 FPCKVGTTPVSSPSQTPRPQPGPIPPHTQVRNQVYSWLLRLRPPSQGYLSSRSPQEMLRA 2061
F +VRN++YS LL L P+ Y SRSPQE+ +A
Sbjct: 677 FK-------------------------KEVRNKIYSRLLSLHSPNS-YYGSRSPQELFKA 710
Query: 2062 SGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSNPAVFRD 2121
SGLTQKWV REISNF+YL+Q+NT+AGRTYNDL+QYPVFPW+LQDY S LDL+NPAVFRD
Sbjct: 711 SGLTQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEELDLNNPAVFRD 770
Query: 2122 LSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGTHYSNAAGVMHYLIRVEPFTSLHV 2181
LSKPIGVVN K+A+ +REKYE+FEDP GTIDKFHYGTHYSN+AGVMHYLIRVEPFT+LH+
Sbjct: 771 LSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMHYLIRVEPFTTLHI 830
Query: 2182 QLQSGRFDCSDRQFHSVAAAWQARLESPADVKELIPEFFYFPDFLENQNGFDLGCLQLTN 2241
QLQSGRFDC+DRQFHS+ A WQA +++P DVKELIPEFFYFP+FLENQN F+LG LQ++
Sbjct: 831 QLQSGRFDCADRQFHSIPATWQALMDNPYDVKELIPEFFYFPEFLENQNQFNLGRLQISK 890
Query: 2242 EKVGDVVLPPWASSPEDFIQQHRQALESEYVSAHLHEWIDLIFGYKQRGPAAEEALNVFY 2301
E V DV+LP WA S EDFI +HR+ALESEYVSAHLHEWIDLIFGYKQRGPAA EALNVFY
Sbjct: 891 ELVNDVILPKWAKSAEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRGPAAVEALNVFY 950
Query: 2302 YCTYEGAVDLDHVTDERERKALEGIISNFGQTPCQLLK 2339
YC+YEGAVDLD +TDE+ERKALEG+I+NFGQTPCQLLK
Sbjct: 951 YCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQLLK 988
Score = 361 bits (926), Expect = 6e-99
Identities = 183/353 (51%), Positives = 250/353 (70%), Gaps = 9/353 (2%)
Query: 2407 LLVTVSASGLLGTHSWLPYDRNISNYFSFSKDPTMGSHKTQRLLSGPWVPGSGVSGQALA 2466
L +T+S + ++GTH WLPYDRNISNYF+F KD T+ + KTQR ++G + PG ++ +
Sbjct: 987 LKITISMNYVIGTHGWLPYDRNISNYFTFIKDQTVTNPKTQRSINGSFAPGLEITSKLFV 1046
Query: 2467 VAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTC 2526
V+ D KLLFS G+WD S++V +L +GK++S + H+D+VTCLA D CGI+LISGSRDTTC
Sbjct: 1047 VSHDAKLLFSAGYWDNSIQVMSLTKGKIISHIIRHMDIVTCLATDYCGIHLISGSRDTTC 1106
Query: 2527 MVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQ 2586
M+W++ QGG+ VGLA KP Q+LYGH V V ISTELDMAVSGS DGTVIIHT+++GQ
Sbjct: 1107 MIWQITQQGGVPVGLASKPFQILYGHTNEVLSVGISTELDMAVSGSRDGTVIIHTIQKGQ 1166
Query: 2587 FVAALRP-----LGATFPGPIFHLALGSEGQIVVQSSAWERPGAQVTYSLHLYSVNGKLR 2641
++ LRP L T P +LA+ EG IVV SS E+ + +LHL+S+NGK
Sbjct: 1167 YMRTLRPPCESSLFLTIP----NLAISWEGHIVVYSSTEEKTTLKDKNALHLFSINGKYL 1222
Query: 2642 ASLPLAEQPTALTVTEDFVLLGTAQCALHILQLNTLLPAAPPLPMKVAIRSVAVTKERSH 2701
S L EQ + + + + ++ G+ Q L I L++L + PL M++ I V VTKE SH
Sbjct: 1223 GSQILKEQVSDICIIGEHIVTGSIQGFLSIRDLHSLNLSINPLAMRLPIHCVCVTKEYSH 1282
Query: 2702 VLVGLEDGKLIVVVAGQPSEVRSSQFARKLWRSSRRISQVSSGETEYNPTEAR 2754
+LVGLEDGKLIVV G+P+E+RS Q +RK W SS+R+SQ+S+GETEYN +++
Sbjct: 1283 ILVGLEDGKLIVVGVGKPAEMRSGQLSRKFWGSSKRLSQISAGETEYNTQDSK 1335
>gi|62422577 neurobeachin [Homo sapiens]
Length = 2946
Score = 468 bits (1203), Expect = e-131
Identities = 308/868 (35%), Positives = 447/868 (51%), Gaps = 96/868 (11%)
Query: 1827 WKLSSAETYSRMRLKLVPNHHFDPHLEA--SALRDNLGEVPLTPTEEASLPLAVTKEAKV 1884
W+L E R R + V N H EA A + E + +++ A+ +
Sbjct: 2066 WRLDYWEDDLRRRRRFVRNAFGSTHAEALLKAAIEYGTEEDVVKSKKTFRSQAIVNQ--- 2122
Query: 1885 STPPELLQEDQLGEDELAELETPMEAAELDEQREKLVLSAECQLVTVVAVVPGLLEVTTQ 1944
+ EL+ E G+D+ L ++ E+D +VLS QL+ V V G L +TT
Sbjct: 2123 NAETELMLE---GDDDAVSL---LQEKEIDNLAGPVVLSTPAQLIAPVVVAKGTLSITTT 2176
Query: 1945 NVYFY----DGSTERVETE-----EGIGYDFRRPLAQLREVHLRRFNLRRSALELFFIDQ 1995
+YF D + ++++T+ EG+ + +++R V RR+ L+ +ALE+F ++
Sbjct: 2177 EIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWM--FSEIRAVFSRRYLLQNTALEVFMANR 2234
Query: 1996 ANYFLNFPCKVGTTPVSSPSQTPRPQPGPIPPHTQVRNQVYSWLLRLRPPSQGYLSSRSP 2055
+ NFP + V PR G Q R +S +P
Sbjct: 2235 TSVMFNFPDQATVKKVVY--SLPRVGVGTSYGLPQARR----------------ISLATP 2276
Query: 2056 QEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSN 2115
+++ ++S +TQ+W +REISNFEYLM LNTIAGRTYNDL+QYPVFPWVL +Y S LDL+
Sbjct: 2277 RQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTL 2336
Query: 2116 PAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGTHYSNAAGVMHYLIRVEP 2175
P FRDLSKPIG +NPK A E+YE++ED +HY THYS A + +L+R+EP
Sbjct: 2337 PGNFRDLSKPIGALNPKRAVFYAERYETWEDDQSP--PYHYNTHYSTATSTLSWLVRIEP 2394
Query: 2176 FTSLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVKELIPEFFYFPDFLENQNGFDLG 2235
FT+ + G+FD DR F SVA +W+ +DVKELIPEF+Y P+ N NG++LG
Sbjct: 2395 FTTFFLNANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLG 2454
Query: 2236 CLQLTNEKVGDVVLPPWASSPEDFIQQHRQALESEYVSAHLHEWIDLIFGYKQRGPAAEE 2295
+ V DV LPPWA PEDF++ +R ALESE+VS LH+WIDLIFGYKQRGP A
Sbjct: 2455 VRE-DEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVR 2513
Query: 2296 ALNVFYYCTYEGAVDLDHVTDERERKALEGIISNFGQTPCQLLKEPHPTRLSAEEAAHRL 2355
ALNVF+Y TYEG+V+LD +TD R+A+E I NFGQTP QLL EPHP R SA
Sbjct: 2514 ALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLC--- 2570
Query: 2356 ARLDTNSPSIFQHLDELKAFFAEVVSDGVPLVLALVPHRQPHSFITQGS-PDL----LVT 2410
L + F + + V +VL P P + + + P L +VT
Sbjct: 2571 ------------FLPQSPLMFKDQMQQDVIMVLKF-PSNSPVTHVAANTLPHLTIPAVVT 2617
Query: 2411 VSASGLLGTHSW---------LPYDRNISNYFSFSKDPTMGSHK--TQRLLSGPWVPGSG 2459
V+ S L + W Y + +++ DP + ++ +R ++
Sbjct: 2618 VTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQ 2677
Query: 2460 VSGQALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGI---- 2515
++ V D + + G WD S RV + GKL + H DVVTCLA I
Sbjct: 2678 INAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDC 2737
Query: 2516 YLISGSRDTTCMVWRLLHQGGL-----SVGLAPKPVQVLYGHGAAVSCVAISTELDMAVS 2570
Y++SGSRD T ++W + + + P P VL GH V CV++ EL + +S
Sbjct: 2738 YIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVIS 2797
Query: 2571 GSEDGTVIIHTVRRGQFVAALRPLGATFPGPIFHLALGSEGQIVVQSSAWERPGAQVTYS 2630
G+++G ++HT+ A P FP I ++ SEG ++ +ER
Sbjct: 2798 GAKEGPCLVHTITGDLLRALEGPENCLFPRLI---SVSSEGHCIIY---YERG------R 2845
Query: 2631 LHLYSVNGKLRASLPLAEQPTALTVTED 2658
+S+NGKL A + + + A+ ++ D
Sbjct: 2846 FSNFSINGKLLAQMEINDSTRAILLSSD 2873
Score = 63.5 bits (153), Expect = 3e-09
Identities = 61/243 (25%), Positives = 103/243 (42%), Gaps = 24/243 (9%)
Query: 488 TCVQAGLVGCLLETLSTGLALEARCQEQLLALLQALGRVSIRPMELRHLLRPRPGLDSEP 547
T + GL+ +L +S A++ + L+ +L L SI EL+ L G
Sbjct: 153 TSTEVGLIEQVLLKMS---AVDDMIADLLVDMLGVLASYSITVKELKLLFSMLRG----- 204
Query: 548 GGAEAGK-ARHAGAVIRTLSGMARHQGPARALRYFDLTPSMAGIMVPPVQRWP-GPGFTF 605
E+G RHA ++ L+ M + GP + S A I +PP+ +WP GFT
Sbjct: 205 ---ESGIWPRHAVKLLSVLNQMPQRHGPDTFFNFPGC--SAAAIALPPIAKWPYQNGFTL 259
Query: 606 HAWLCLHPMDTAPTPAPTRPLQRKQLYSFFTSSGSGFEAFFTAAGTLVVAVCTRKEYLTM 665
+ W + P++ + LY F TS G G+ A F L+V K
Sbjct: 260 NTWFRMDPLNNINVDK-----DKPYLYCFRTSKGVGYSAHF-VGNCLIVTSLKSKGKGFQ 313
Query: 666 SLPEVSFADSAWHCVAIVHVPGRRPFSQNLVHVYKDGHLVKTAPLRC-PSLSEPFSSCCI 724
+ F W+ ++IVH+ R + + + Y +G LV + + ++ + C +
Sbjct: 314 HCVKYDFQPRKWYMISIVHIYNR--WRNSEIRCYVNGQLVSYGDMAWHVNTNDSYDKCFL 371
Query: 725 GSA 727
GS+
Sbjct: 372 GSS 374
Score = 61.2 bits (147), Expect = 1e-08
Identities = 86/383 (22%), Positives = 148/383 (38%), Gaps = 80/383 (20%)
Query: 801 GELGAVAIFHEALQATALRTLCTLGP--NETAPFKPEGELH------------ELSTRLL 846
G+LGAV +F EAL + + LGP T FK E ++H +L++ +
Sbjct: 385 GQLGAVYVFSEALNPAQIFAIHQLGPGYKSTFKFKSESDIHLAEHHKQVLYDGKLASSIA 444
Query: 847 LHYSPQACKNNICLDLSPSHGLDGRL-TGHRVETWDVKDVV--------NCVGGMGALLP 897
Y+ +A +CL+ SP + + H + DVK +V + +GG+ L P
Sbjct: 445 FTYNAKATDAQLCLESSPKENASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGIQVLFP 504
Query: 898 LLERVAAQPKEAEAGPAETHDLVGPELTSGHNTQGLVLPLGKSSEERMERNAVAAFLLML 957
L + L + ++ ++E A L L
Sbjct: 505 LFAQ---------------------------------LDNRQLNDSQVETTVCATLLAFL 531
Query: 958 RNFLQGHMVNQESLVQCQGPAIIGALLRKVPSWAMDMNVLMSAQLLMEQVAAEGSG-PLL 1016
L+ + QE ++ +G +IG LL K + VL + + G PLL
Sbjct: 532 VELLKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLSHGAPLL 591
Query: 1017 YLLYQHLLFNFHLWTLSDFAVRLGHIQYMSSI---VREHRQKLRKKYGVQFILDALRTHY 1073
L H+LFN +W + V+L Y+S+ +R+ V ++ L+ +Y
Sbjct: 592 KQLCDHILFNPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYY 651
Query: 1074 ------SPQRERPLAADDLRTVQTSLLGLAREFLV----------RSLSADDVQVTQTML 1117
P D R Q ++ L R F++ R + D++ Q++L
Sbjct: 652 WVINPADSSGITPKGLDGPRPSQKEIISL-RAFMLLFLKQLILKDRGVKEDEL---QSIL 707
Query: 1118 SFLAATGDDGQAVGALDLLLALL 1140
++L +D L LL+AL+
Sbjct: 708 NYLLTMHEDENIHDVLQLLVALM 730
>gi|148233596 LPS-responsive vesicle trafficking, beach and anchor
containing [Homo sapiens]
Length = 2863
Score = 455 bits (1171), Expect = e-127
Identities = 318/949 (33%), Positives = 481/949 (50%), Gaps = 117/949 (12%)
Query: 1815 GAW--ALRDTPIPRWKLSSAETYSRMRLKLVPNHHFDPHLEASALRDNLGEVPLTPTEEA 1872
GAW + P+ W+L E R R + V N H EA+ L+ + V + E
Sbjct: 1966 GAWGNSAVSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEAT-LKTAVEHVCIFKLREN 2024
Query: 1873 SLPLAVTKEAKVSTPPELLQEDQLG----EDELA-----ELETPMEAAELDEQREKLVLS 1923
S T E ++ + ++ LG E+E+ + + ++ +L+ + LS
Sbjct: 2025 S---KATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGPVSLS 2081
Query: 1924 AECQLVTVVAVVPGLLEVTTQNVYFY----DGSTERVETE-----EGIGYDFRRPLAQLR 1974
QLV VV G L VT+ +YF D + ++++ + EG+ + ++R
Sbjct: 2082 TPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWL--FTEIR 2139
Query: 1975 EVHLRRFNLRRSALELFFIDQANYFLNFPCKVGTTPVSSPSQTPRPQPGPIPPHTQVRNQ 2034
+ RR+ L+ +ALE+F ++ NFP V + PR G Q R
Sbjct: 2140 SIFSRRYLLQNTALEIFMANRVAVMFNFPDPATVKKVVN--YLPRVGVGTSFGLPQTRR- 2196
Query: 2035 VYSWLLRLRPPSQGYLSSRSPQEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLS 2094
+S SP+++ +AS +TQ+W REISNFEYLM LNTIAGR+YNDL+
Sbjct: 2197 ---------------ISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLN 2241
Query: 2095 QYPVFPWVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKF 2154
QYPVFPWV+ +Y S LDL+ P FRDLSKPIG +NPK A E+YES+ED + KF
Sbjct: 2242 QYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQ--VPKF 2299
Query: 2155 HYGTHYSNAAGVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVKE 2214
HYGTHYS A+ V+ +L+R+EPFT+ + LQ G+FD +DR F S++ AW+ +D+KE
Sbjct: 2300 HYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKE 2359
Query: 2215 LIPEFFYFPDFLENQNGFDLGCLQLTNEKVGDVVLPPWASSPEDFIQQHRQALESEYVSA 2274
LIPEF+Y P+ N N ++LG + V DV LPPWA + E+F+ +R ALESE+VS
Sbjct: 2360 LIPEFYYLPEMFVNFNNYNLGVMD-DGTVVSDVELPPWAKTSEEFVHINRLALESEFVSC 2418
Query: 2275 HLHEWIDLIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVTDERERKALEGIISNFGQTP 2334
LH+WIDLIFGYKQ+GP A ALNVFYY TYEGAV+L+ +TD R+A+E I +FGQTP
Sbjct: 2419 QLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTP 2478
Query: 2335 CQLLKEPHPTRLSAEEAAHRLARLDTNSPSIFQHLDELKAFFAEVVSDGVPLVLALVPHR 2394
QLL EPHP R SA + + F + V +VL P
Sbjct: 2479 SQLLIEPHPPRGSAMQVS--------------------PLMFTDKAQQDVIMVLKF-PSN 2517
Query: 2395 QPHSFITQGS-PDL----LVTVSASGLLGTHSW--LPYDRNISN----YFSFSKDPTMGS 2443
P + + + P L ++TV+A+ L + W LP + DP + S
Sbjct: 2518 SPVTHVAANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIAS 2577
Query: 2444 H--KTQRLLSGPWVPGSGVSGQALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCH 2501
+ +R ++ V Q + D + + G WD S RV + G+L+ + H
Sbjct: 2578 NTGMHRRQITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGH 2637
Query: 2502 LDVVTCLALDTCGI----YLISGSRDTTCMVWRLLHQGGLSVGLAPKPVQ-------VLY 2550
DVVTCLA I Y++SGSRD T ++W + G G+ P +L
Sbjct: 2638 WDVVTCLARSESYIGGNCYILSGSRDATLLLW---YWNGKCSGIGDNPGSETAAPRAILT 2694
Query: 2551 GHGAAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQFVAALRPLGATFPGPIFHLALGSE 2610
GH V+C A+ EL + +SGS++G +IH++ G + G E
Sbjct: 2695 GHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMN----------------GDLLRTLEGPE 2738
Query: 2611 GQIVVQSSAWERPGAQVTYSLH----LYSVNGKLRASLPLAEQPTALTVTED--FVLLGT 2664
+ + R G V + + +SVNGKL+A++ + A+ ++ D ++L G
Sbjct: 2739 NCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGG 2798
Query: 2665 AQCALHILQLNTLLPAAPPLPMKVAIRSVAVTKERSHVLVGLEDGKLIV 2713
+ + + Q++ L IR++A++ ++ ++ G+ G +++
Sbjct: 2799 DRGVVVVRQVSDLKQLFAYPGCDAGIRAMALSYDQRCIISGMASGSIVL 2847
Score = 87.8 bits (216), Expect = 1e-16
Identities = 154/693 (22%), Positives = 249/693 (35%), Gaps = 157/693 (22%)
Query: 489 CVQAGLVGCLLETLSTGLALEARCQEQLLALLQALGRVSIRPMELRHLLRPRPGLDSEPG 548
C + GLV +L + ++ + L+ +L L ++ EL+ S+
Sbjct: 128 CTEVGLVEKVLGKIEK---VDNMIADLLVDMLGVLASYNLTVRELKLFF-------SKLQ 177
Query: 549 GAEAGKARHAGAVIRTLSGMARHQGPARALRYFDLTPSMAGIMVPPVQRWPGP-GFTFHA 607
G + HAG ++ L M + GP + S A I +PP+ +WP GFTFH
Sbjct: 178 GDKGRWPPHAGKLLSVLKHMPQKYGPDAFFNFPG--KSAAAIALPPIAKWPYQNGFTFHT 235
Query: 608 WLCLHPMDTAPTPAPTRPLQRKQLYSFFTSSGSGFEAFFTAAGTLVVAVCTRKEYLTMSL 667
WL + P++ + LY F TS G G+ A F G L+V K
Sbjct: 236 WLRMDPVNNINVDK-----DKPYLYCFRTSKGLGYSAHFVG-GCLIVTSIKSKGKGFQHC 289
Query: 668 PEVSFADSAWHCVAIVHVPGRRPFSQNLVHVYKDGHLVKTAPLRCPSLSEPFSSCCIGSA 727
+ F W+ V I VH+Y K + LRC E + S
Sbjct: 290 VKFDFKPQKWYMVTI-------------VHIYNRW---KNSELRCYVNGE------LASY 327
Query: 728 GYRTTTTTTGLPTPPVPATLAYTHPALTRSQSVPASTGLGWGSGLVAPLQEGSIDSTLAG 787
G T T + D G
Sbjct: 328 GEITWFVNTS-----------------------------------------DTFDKCFLG 346
Query: 788 TQDTRWGSPTSLEGELGAVAIFHEALQATALRTLCTLGPNE--TAPFKPEGELH------ 839
+ +T + G++ AV +F EAL A + + LG T FK E +L
Sbjct: 347 SSETADANRVFC-GQMTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHK 405
Query: 840 ------ELSTRLLLHYSPQACKNNICLDLSPSHGLDGRL-TGHRVETWDVKDVV------ 886
+LS+ + Y+P+A +CL+ SP + + H + DVK V+
Sbjct: 406 LLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQS 465
Query: 887 --NCVGGMGALLPLLERVAAQPKEAEAGPAETHDLVGPELTSGHNTQGLVLPLGKSSEER 944
+ +GG+ L PL + L + +
Sbjct: 466 AMHSIGGVQVLFPLFAQ---------------------------------LDYRQYLSDE 492
Query: 945 MERNAVAAFLLMLRNFLQGHMVNQESLVQCQGPAIIGALLRKVPSWAMDMNVLMSAQLLM 1004
++ + L + L+ + QE ++ C+G +IG L K + VL
Sbjct: 493 IDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHVSRAVLELCLAFS 552
Query: 1005 EQVAAEGSG-PLLYLLYQHLLFNFHLWTLSDFAVRLGHIQYMSSI---VREHRQKLRKKY 1060
+ ++ +G PLL L H+L N +W + V+L Y+S+ +R+
Sbjct: 553 KYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVG 612
Query: 1061 GVQFILDALRTHY---SPQRE---RPLAADDLRTVQTSLLGLAREFL---VRSLSADDVQ 1111
V I+ L+ +Y +PQ P D R Q +L L R FL ++ L D
Sbjct: 613 TVLLIMHTLKYYYWAVNPQDRSGITPKGLDGPRPNQKEMLSL-RAFLLMFIKQLVMKDSG 671
Query: 1112 V----TQTMLSFLAATGDDGQAVGALDLLLALL 1140
V Q +L++L +D + L LL+AL+
Sbjct: 672 VKEDELQAILNYLLTMHEDDNLMDVLQLLVALM 704
>gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 3526
Score = 395 bits (1014), Expect = e-109
Identities = 265/732 (36%), Positives = 371/732 (50%), Gaps = 121/732 (16%)
Query: 1893 EDQLGEDELAELETPMEAA---ELDEQREKLVLSAECQLVTVVAVVPGLLEVTTQNVYFY 1949
+DQ+ E E E + A L E+ EK+ C V + GLL ++ Y
Sbjct: 2506 QDQIAEGSSIEEEEKTDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLLLFGKEHFYVI 2565
Query: 1950 DG----STERVETEEGIGYDFRRPLA---------------------QLREVHLRRFNLR 1984
DG +T + E + + P+ ++EVH RR+ L+
Sbjct: 2566 DGFTMTATREIRDIETLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVHKRRYLLQ 2625
Query: 1985 RSALELFFIDQANYFLNFPCKVGTTPVSSPSQTPRPQPGPIPPHTQVRNQVYSWLLRLRP 2044
A+E+F D NY L F Q G +RN+VY L + P
Sbjct: 2626 PIAVEVFSGDGRNYLLAF------------------QKG-------IRNKVYQRFLAVVP 2660
Query: 2045 P----SQGYLSSRSPQEMLRASGL----------TQKWVQREISNFEYLMQLNTIAGRTY 2090
S+ R + + SGL TQ+W + EISNF+YLM LNT+AGR+Y
Sbjct: 2661 SLTDSSESVSGQRPNTSVEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSY 2720
Query: 2091 NDLSQYPVFPWVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGT 2150
NDL QYPVFPW+L DY S +DL+NP FR+L+KP+G + +++Y+ +EDP G
Sbjct: 2721 NDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGE 2780
Query: 2151 IDKFHYGTHYSNAAGVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAW-QARLESP 2209
+HYGTHYS+A V YL+R+EPFT + ++LQ G FD +DR FHSV AW A +
Sbjct: 2781 TPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNM 2840
Query: 2210 ADVKELIPEFFYFPDFLENQNGFDLGCLQLTNEKVGDVVLPPWA-SSPEDFIQQHRQALE 2268
ADVKELIPEFFY P+FL N N FDLGC Q K+GDV+LPPWA P +FI+ HR+ALE
Sbjct: 2841 ADVKELIPEFFYLPEFLFNSNNFDLGCKQ-NGTKLGDVILPPWAKGDPREFIRVHREALE 2899
Query: 2269 SEYVSAHLHEWIDLIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVTDERERKALEGIIS 2328
+YVSAHLHEWIDLIFGYKQ+GPAA EA+NVF++ YEG VD+ ++ D + A G I+
Sbjct: 2900 CDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFIN 2959
Query: 2329 NFGQTPCQLLKEPHP-----TRLSAEEAAHRLARLDTNSPSIFQHLDELKAFFAEVVSDG 2383
NFGQ P QL K+PHP +RL+ + A + T+ F HLD L+
Sbjct: 2960 NFGQIPKQLFKKPHPPKRVRSRLNGDNAGISVLPGSTSDKIFFHHLDNLR---------- 3009
Query: 2384 VPLVLALVPHRQPHSFITQGSPDLLVTVSASGLLGTHSWLPYDRNISNYFSFSK-DPTMG 2442
P + + ++P I +L V + +L +W N + + ++ +G
Sbjct: 3010 -PSLTPVKELKEPVGQIVCTDKGIL-AVEQNKVLIPPTW-----NKTFAWGYADLSCRLG 3062
Query: 2443 SHKTQRLLS-----GPWVPGSGVSGQAL-AVAPDGKLLFSGGH------WDGSLRVTALP 2490
++++ + ++ W GQ L A+ P+ KL+ +GG W+
Sbjct: 3063 TYESDKAMTVYECLSEW-------GQILCAICPNPKLVITGGTSTVVCVWEMGTSKEKAK 3115
Query: 2491 RGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWRLLHQGGLSVGLAPKPVQVLY 2550
L L H D VTC ++SGSRD TC++W L L+ L
Sbjct: 3116 TVTLKQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLT---------QLR 3166
Query: 2551 GHGAAVSCVAIS 2562
GH A VS + I+
Sbjct: 3167 GHRAPVSALCIN 3178
Score = 40.0 bits (92), Expect = 0.032
Identities = 46/185 (24%), Positives = 72/185 (38%), Gaps = 26/185 (14%)
Query: 2460 VSGQALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGI---- 2515
V + + P F+ G+ D S R+ K ++ C + L C I
Sbjct: 3035 VEQNKVLIPPTWNKTFAWGYADLSCRLGTYESDKAMTVYECLSEWGQIL----CAICPNP 3090
Query: 2516 -YLISGSRDTTCMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSED 2574
+I+G T VW + + + K Q L GH V+C S + VSGS D
Sbjct: 3091 KLVITGGTSTVVCVWEMGTSKEKAKTVTLK--QALLGHTDTVTCATASLAYHIIVSGSRD 3148
Query: 2575 GTVIIHTVRRGQFVAALRPLGATFPGPIFHLALGS-EGQIVVQSSAWERPGAQVTYSLHL 2633
T II + + F+ LR A P+ L + G IV + + +H+
Sbjct: 3149 RTCIIWDLNKLSFLTQLRGHRA----PVSALCINELTGDIVSCAGTY----------IHV 3194
Query: 2634 YSVNG 2638
+S+NG
Sbjct: 3195 WSING 3199
>gi|191252801 WDFY family member 4 [Homo sapiens]
Length = 3184
Score = 334 bits (857), Expect = 6e-91
Identities = 312/1088 (28%), Positives = 468/1088 (43%), Gaps = 167/1088 (15%)
Query: 1710 WRHFIDKQVQPTMSQFEMDTYAKSHDLMSGFWNACYDMLMSSGQRRQWERAQSRRAFQEL 1769
W+H++ + + S+ + +H W+ M RQ + + +
Sbjct: 2171 WQHYLASEKKSLASRSNV-----AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVS 2225
Query: 1770 VLEPAQRRAR-LEGLRYTAVLKQQATQHSMALLHWGALWRQLASPCGAWALRDT--PIPR 1826
+E +RR + L Y ++++ + A W + QL G W+ + P
Sbjct: 2226 CIENYRRRGQELYASLYKDHVQRRKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSP 2285
Query: 1827 WKLSSAETYSRMRLKLVPNHHFDP-----HLEASALRDNLGEVPLTPTEEASLPLAVTKE 1881
W+L E +RMR ++ + H E+ D++ + +E +L A +
Sbjct: 2286 WELDWREGPARMRKRIKRLSPLEALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEP 2345
Query: 1882 AKVSTPPELLQ-----EDQLGEDELAELETPMEAAELDEQREKLVLSAECQLVTVVA--V 1934
+V L + L ++ EL + L E +K ++ + LV V V
Sbjct: 2346 DEVGVDCTQLTFFPALHESLHSEDFLELCRERQVI-LQELLDKEKVTQKFSLVIVQGHLV 2404
Query: 1935 VPGLLEVTTQNVYFYDGSTERVETEEGIGYDFRRPL------------------------ 1970
G+L Q+ Y + T + G Y R L
Sbjct: 2405 SEGVLLFGHQHFYICENFTL---SPTGDVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQ 2461
Query: 1971 ----AQLREVHLRRFNLRRSALELFFIDQANYFLNFPCKVGTTPVSSPSQTPRPQPGPIP 2026
A +RE+ RF L+ ALE+FF + + FL F
Sbjct: 2462 CHSYADMRELRQARFLLQDIALEIFFHNGYSKFLVF------------------------ 2497
Query: 2027 PHTQVRNQVYSWLLRLRPPSQGYLSSRSPQEMLRASG----LTQKWVQREISNFEYLMQL 2082
+ R++ + +P +G +S + R G + QKW +R+ISNFEYLM L
Sbjct: 2498 -YNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDISNFEYLMYL 2556
Query: 2083 NTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKHAQLVREKYE 2142
NT AGRT ND QYPVFPWVL DY S TL+L+NP +FRDLSKP+G + ++++
Sbjct: 2557 NTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFK 2616
Query: 2143 SFEDPAGTID-KFHYGTHYSNAAGVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAA 2201
E G + + HY THYS+A V YL+R+ PFT LQ G FD +DR FHSV +
Sbjct: 2617 EVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADRMFHSVKST 2676
Query: 2202 WQ-ARLESPADVKELIPEFFYFPDFLENQNGFDLGCLQLTNEKVGDVVLPPWASS-PEDF 2259
W+ A E+ +DV+EL PEFFY P+FL N NG + GC+Q +GDV LPPWA P F
Sbjct: 2677 WESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQ-DGTVLGDVQLPPWADGDPRKF 2735
Query: 2260 IQQHRQALESEYVSAHLHEWIDLIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVTDERE 2319
I HR+ALES++VSA+LH WIDLIFGYKQ+GPAA +A+N+F+ Y +DL +TD
Sbjct: 2736 ISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLI 2795
Query: 2320 RKALEGIISNFGQTPCQLLKEPHPTRLSAEEAAHRLARLDTNSPSIFQHLDELKAFFAEV 2379
+ + G +SNFGQ P QL +PHP R +A + L D ++P
Sbjct: 2796 KSTILGFVSNFGQVPKQLFTKPHPARTAAGKP---LPGKDVSTP---------------- 2836
Query: 2380 VSDGVPLVLALVPHRQPHSFITQGSPDLLVTV-----------SASGLLG-----THSWL 2423
++L H QP + Q VTV S G +G + L
Sbjct: 2837 --------VSLPGHPQPFFYSLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTIL 2888
Query: 2424 PYDRN-------ISNYFSFSKDP---TMGSHKTQRLLSGPWVPGSGVSGQAL-AVAPDGK 2472
+RN + FS+ D +GS+ + ++L G+ L AV P
Sbjct: 2889 AVERNKVLLPPLWNRTFSWGFDDFSCCLGSYGSDKVLM--TFENLAAWGRCLCAVCPSPT 2946
Query: 2473 LLFSGGH------WDGSLRVTALPRGKLLSQ-LSCHLDVVTCLALDTCGIYLISGSRDTT 2525
+ + G W+ S+ PRG L Q L H VTCLA L+SGS+D T
Sbjct: 2947 TIVTSGTSTVVCVWELSM-TKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCT 3005
Query: 2526 CMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVS--GSEDGTVIIHTVR 2583
C++W L H V L H +S + IS VS G+ ++
Sbjct: 3006 CILWDLDHL---------THVTRLPAHREGISAITISDVSGTIVSCAGAHLSLWNVNGQP 3056
Query: 2584 RGQFVAALRPLGATFPGPIFHLALGSEGQIVVQSSAWERPGAQVTYSLHLYSVNGKLRAS 2643
A P GA + QI++ S T + + SV G+
Sbjct: 3057 LASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVWKTEDVKM-SVPGRPAGE 3115
Query: 2644 LPLAEQPTALTVTEDFVLLGTAQCALHILQLNTLLPAAPPLPMKVAIRSVAVTKERSHVL 2703
P A+ P+ + L + + + I P A+ ++AV++ + +L
Sbjct: 3116 EPPAQPPSPRGHKWEKNLALSRELDVSIAL------TGKPSKTSPAVTALAVSRNHTKLL 3169
Query: 2704 VGLEDGKL 2711
VG E G++
Sbjct: 3170 VGDERGRI 3177
>gi|31543297 neutral sphingomyelinase (N-SMase) activation associated
factor isoform 1 [Homo sapiens]
Length = 917
Score = 304 bits (779), Expect = 7e-82
Identities = 226/709 (31%), Positives = 345/709 (48%), Gaps = 102/709 (14%)
Query: 1894 DQLGEDEL---AELETPMEAAELDEQR-----EKLVLSAECQLVTVVAVVPGLLEVTTQN 1945
D+LG+ A L++ + D+ R EKL + + ++VT + PG + +T N
Sbjct: 160 DKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKAEMVTPLVTNPGHVCITDTN 219
Query: 1946 VYFYDGSTERVETEEGIGYDFRRPLAQL-----REVHLRRFNLRRSALELFFIDQ---AN 1997
+YF + GY +P+ Q+ R ++ RR L LE+F + ++
Sbjct: 220 LYFQPLN----------GYP--KPVVQITLQDVRRIYKRRHGLMPLGLEVFCTEDDLCSD 267
Query: 1998 YFLNFPCKVGTTPVSSPSQTPRPQPGPIPPHTQVRNQVYSWLLRLRPPSQGYLSSRSPQE 2057
+L F Q R+ +Y ++ YL +
Sbjct: 268 IYLKFY------------------------EPQDRDDLYFYIAT-------YLEHHVAEH 296
Query: 2058 MLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSNPA 2117
A +W + +SN++YL+ LN +A R+ NDLSQYPVFPW++ DY S LDLSNP
Sbjct: 297 T--AESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPG 354
Query: 2118 VFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGTHYSNAAGVMHYLIRVEPFT 2177
FRDLSKP+G +N + + + +Y+ +P KF YG+HYS+ V+ YL+R+ P
Sbjct: 355 TFRDLSKPVGALNKERLERLLTRYQEMPEP-----KFMYGSHYSSPGYVLFYLVRIAPEY 409
Query: 2178 SLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVKELIPEFFYFP-DFLENQNGFDLGC 2236
L LQ+GRFD +DR F+S+A W+ L+ D KELIPEF+ FL N DLG
Sbjct: 410 MLC--LQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYGDDVSFLVNSLKLDLGK 467
Query: 2237 LQLTNEKVGDVVLPPWASSPEDFIQQHRQALESEYVSAHLHEWIDLIFGYKQRGPAAEEA 2296
Q + V DV LPPWASSPEDF+Q+ + ALES YVS HLHEWIDLIFGYKQ+G A A
Sbjct: 468 RQ-GGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQKGSDAVGA 526
Query: 2297 LNVFYYCTYEGAVDLDHVTDERERKALEGIISNFGQTPCQLLKEPHPTRLS------AEE 2350
NVF+ TYEG VDL+ + D E+ A+ I FGQTP QL PHP R++ ++
Sbjct: 527 HNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRITPKFKSLSQT 586
Query: 2351 AAHRLARLDTNSPSIFQHLDELKAFFAEVVSDGVPLVLALVPHRQPHSFITQGSPDLLVT 2410
+++ + D+ F+ L E ++ ++ L L H + H G +T
Sbjct: 587 SSYNASMADSPGEESFEDLTE----ESKTLAWNNITKLQLHEHYKIHKEAVTG-----IT 637
Query: 2411 VSASGLLGTHSWLPYDRNISNYFSFSKDPTMGSHKTQRLLSGPWVPGSGVSGQALAVAPD 2470
VS RN S+ F+ S+D T+ + + + S ++ + + P
Sbjct: 638 VS--------------RNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPG 683
Query: 2471 GKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWR 2530
+ + WD ++ ++ G+ L H D V+ + +Y S S D+T VW
Sbjct: 684 DATVITSS-WDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLY--SASWDSTVKVWS 740
Query: 2531 LLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVII 2579
+ + H +V ++++ + VSG+++GTV I
Sbjct: 741 GVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNI 789
Score = 42.7 bits (99), Expect = 0.005
Identities = 32/113 (28%), Positives = 54/113 (47%), Gaps = 13/113 (11%)
Query: 2466 AVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTT 2525
A +PD + + S G DG L V + G L+S ++ + C D G ++SGS+
Sbjct: 812 AFSPDSRHVLSTGT-DGCLNVIDVQTGMLISSMTSD-EPQRCFVWD--GNSVLSGSQSGE 867
Query: 2526 CMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVI 2578
+VW LL K + + GH AV+C+ ++ + ++G ED +I
Sbjct: 868 LLVWDLL---------GAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQII 911
>gi|221625547 neutral sphingomyelinase (N-SMase) activation associated
factor isoform 2 [Homo sapiens]
Length = 948
Score = 304 bits (779), Expect = 7e-82
Identities = 226/709 (31%), Positives = 345/709 (48%), Gaps = 102/709 (14%)
Query: 1894 DQLGEDEL---AELETPMEAAELDEQR-----EKLVLSAECQLVTVVAVVPGLLEVTTQN 1945
D+LG+ A L++ + D+ R EKL + + ++VT + PG + +T N
Sbjct: 191 DKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKAEMVTPLVTNPGHVCITDTN 250
Query: 1946 VYFYDGSTERVETEEGIGYDFRRPLAQL-----REVHLRRFNLRRSALELFFIDQ---AN 1997
+YF + GY +P+ Q+ R ++ RR L LE+F + ++
Sbjct: 251 LYFQPLN----------GYP--KPVVQITLQDVRRIYKRRHGLMPLGLEVFCTEDDLCSD 298
Query: 1998 YFLNFPCKVGTTPVSSPSQTPRPQPGPIPPHTQVRNQVYSWLLRLRPPSQGYLSSRSPQE 2057
+L F Q R+ +Y ++ YL +
Sbjct: 299 IYLKFY------------------------EPQDRDDLYFYIAT-------YLEHHVAEH 327
Query: 2058 MLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSNPA 2117
A +W + +SN++YL+ LN +A R+ NDLSQYPVFPW++ DY S LDLSNP
Sbjct: 328 T--AESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPG 385
Query: 2118 VFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGTHYSNAAGVMHYLIRVEPFT 2177
FRDLSKP+G +N + + + +Y+ +P KF YG+HYS+ V+ YL+R+ P
Sbjct: 386 TFRDLSKPVGALNKERLERLLTRYQEMPEP-----KFMYGSHYSSPGYVLFYLVRIAPEY 440
Query: 2178 SLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVKELIPEFFYFP-DFLENQNGFDLGC 2236
L LQ+GRFD +DR F+S+A W+ L+ D KELIPEF+ FL N DLG
Sbjct: 441 MLC--LQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYGDDVSFLVNSLKLDLGK 498
Query: 2237 LQLTNEKVGDVVLPPWASSPEDFIQQHRQALESEYVSAHLHEWIDLIFGYKQRGPAAEEA 2296
Q + V DV LPPWASSPEDF+Q+ + ALES YVS HLHEWIDLIFGYKQ+G A A
Sbjct: 499 RQ-GGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQKGSDAVGA 557
Query: 2297 LNVFYYCTYEGAVDLDHVTDERERKALEGIISNFGQTPCQLLKEPHPTRLS------AEE 2350
NVF+ TYEG VDL+ + D E+ A+ I FGQTP QL PHP R++ ++
Sbjct: 558 HNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRITPKFKSLSQT 617
Query: 2351 AAHRLARLDTNSPSIFQHLDELKAFFAEVVSDGVPLVLALVPHRQPHSFITQGSPDLLVT 2410
+++ + D+ F+ L E ++ ++ L L H + H G +T
Sbjct: 618 SSYNASMADSPGEESFEDLTE----ESKTLAWNNITKLQLHEHYKIHKEAVTG-----IT 668
Query: 2411 VSASGLLGTHSWLPYDRNISNYFSFSKDPTMGSHKTQRLLSGPWVPGSGVSGQALAVAPD 2470
VS RN S+ F+ S+D T+ + + + S ++ + + P
Sbjct: 669 VS--------------RNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPG 714
Query: 2471 GKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWR 2530
+ + WD ++ ++ G+ L H D V+ + +Y S S D+T VW
Sbjct: 715 DATVITSS-WDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLY--SASWDSTVKVWS 771
Query: 2531 LLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVII 2579
+ + H +V ++++ + VSG+++GTV I
Sbjct: 772 GVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNI 820
Score = 42.7 bits (99), Expect = 0.005
Identities = 32/113 (28%), Positives = 54/113 (47%), Gaps = 13/113 (11%)
Query: 2466 AVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTT 2525
A +PD + + S G DG L V + G L+S ++ + C D G ++SGS+
Sbjct: 843 AFSPDSRHVLSTGT-DGCLNVIDVQTGMLISSMTSD-EPQRCFVWD--GNSVLSGSQSGE 898
Query: 2526 CMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVI 2578
+VW LL K + + GH AV+C+ ++ + ++G ED +I
Sbjct: 899 LLVWDLL---------GAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQII 942
>gi|54292123 lysosomal trafficking regulator [Homo sapiens]
Length = 3801
Score = 293 bits (750), Expect = 2e-78
Identities = 285/981 (29%), Positives = 433/981 (44%), Gaps = 164/981 (16%)
Query: 1732 KSHDLMSGFWNACYDMLMSSGQRRQWERAQSR-RAFQELVLEPAQRRARLEGLRYTAVLK 1790
K ++ G A + +++ Q+ ++R S+ + ++ + Q + +G V++
Sbjct: 2848 KKYETEEGVNKAAWQKTVNNNQQSLFQRLDSKSKDISKIAADITQAVSLSQGNERKKVIQ 2907
Query: 1791 QQATQHSMALL---HWGALWRQLASPCGAWALRDTPIPRWKLSSAETYSRMRLKL----- 1842
+ + L HW L +QL W W+L E +R R +L
Sbjct: 2908 HIRGMYKVDLSASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCYL 2967
Query: 1843 -VPNHHFDPHLEASALRDNLGEVPLTPTEEASLPLAVTKEAKVSTPPELLQEDQLGEDEL 1901
+PN + LRD E V P L ED+
Sbjct: 2968 TIPNKYL--------LRDRQ-----------------KSEDVVKPPLSYLFEDKTHSSFS 3002
Query: 1902 AELETPMEAAELDEQREKLVLSAECQLVTVVAVVPGLLEVTTQNVYFY-DGSTERVETEE 1960
+ ++ + E + ++ C V G L + +YF D +++ VE+
Sbjct: 3003 STVKDKAAS-------ESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVESSS 3055
Query: 1961 GIGY----DFRRPLAQLREVHLRRFNLRRSALELFFIDQANYFLNFPCKVGTTPVSSPSQ 2016
G F +++EVH R + LR +A+E+F + L F
Sbjct: 3056 LQGELEPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFD------------- 3102
Query: 2017 TPRPQPGPIPPHTQVRNQVYSWLLRLRPPSQGYLSSRSPQEMLRASGLTQKWVQREISNF 2076
+T+VR+ VY +L P+ E + LT W +I+NF
Sbjct: 3103 -----------NTKVRDDVYHNILTNNLPNL--------LEYGNITALTNLWYTGQITNF 3143
Query: 2077 EYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKHAQL 2136
EYL LN AGR++NDL QYPVFP++L DYVS TLDL++ ++R+LSKPI V +
Sbjct: 3144 EYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYRNLSKPIAVQYKEKEDR 3203
Query: 2137 VREKYESFE----------DPAGTIDKFHYGTHYSNAAGVMHYLIRVEPFTSLHVQLQSG 2186
+ Y+ E DP + +HYG+HYSN+ V+H+L+R+ PFT + + Q
Sbjct: 3204 YVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMFLAYQDQ 3263
Query: 2187 RFDCSDRQFHSVAAAWQ-ARLESPADVKELIPEFFYFPDFLENQNGFDLGCLQLTNEKVG 2245
FD DR FHS W+ + ES DVKELIPEFFY P+FL N+ GFD G Q E+V
Sbjct: 3264 SFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQ-NGERVN 3322
Query: 2246 DVVLPPWA-SSPEDFIQQHRQALESEYVSAHLHEWIDLIFGYKQRGPAAEEALNVFYYCT 2304
V LPPWA + P FI HRQALES+YVS ++ +WIDL+FGYKQ+G A+ +A+NVF+ T
Sbjct: 3323 HVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINVFHPAT 3382
Query: 2305 YEGAVDLDHVTDERERKALEGIISNFGQTPCQLLKEPHPTRLSAE--------------- 2349
Y G +D+ V D +R+ALE +I +GQTP QL H +R A+
Sbjct: 3383 YFG-MDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGAKLNIEGELPAAVGLLV 3441
Query: 2350 EAAHRLAR---LDTNSPSIFQHLDELK-AFFAEVVSDGVPLVLALVPHRQ--------PH 2397
+ A R R + PS + LK + S VP+V PH + P
Sbjct: 3442 QFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPT 3501
Query: 2398 SFITQGSPDLLVTVSASGLLGTHSWLPYDRNISNYFSFSKDPTMGSHKTQRLLSGPWVPG 2457
I S + + ++ S G S D S S+ + K+++ S P V
Sbjct: 3502 RAICGLSRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYADNILRLKSKQ--SEPPVNF 3559
Query: 2458 SGVSGQ----ALAVAPDGKLLFSGGHWD----GSLRVTALPRGKLLSQLSCHL----DVV 2505
S Q + A PD LF+G + R T+ ++ + HL + +
Sbjct: 3560 IQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLYGHTEEI 3619
Query: 2506 TCLALDTCGIYLISGSRDTTCMVW---RLLHQGGLSVGLAPKPVQVLYGHGAAVSCVA-- 2560
T L + LIS SRD TC++W RL + VQ L GH + V+ V+
Sbjct: 3620 TSLFVCKPYSILISVSRDGTCIIWDLNRLCY------------VQSLAGHKSPVTAVSAS 3667
Query: 2561 -----ISTELDMAVSGSE------DGTVIIHTVRRGQFVAALRPLGATFPGPIFHLALGS 2609
I+T D A GS+ +G ++ H V + + ++ I +A G
Sbjct: 3668 ETSGDIATVCDSAGGGSDLRLWTVNGDLVGH-VHCREIICSVAFSNQPEGVSINVIAGGL 3726
Query: 2610 EGQIVVQSSAWE-RPGAQVTY 2629
E IV S W+ +P ++T+
Sbjct: 3727 ENGIVRLWSTWDLKPVREITF 3747
>gi|239756689 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 1941
Score = 107 bits (267), Expect = 2e-22
Identities = 97/310 (31%), Positives = 131/310 (42%), Gaps = 68/310 (21%)
Query: 2056 QEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSN 2115
QE LR+ L WV ISNF YLMQLN +AGR D + +PV PWV+ D+ +P
Sbjct: 342 QEELRS--LVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV-DFTTPH----- 393
Query: 2116 PAVFRDLSKPIGVVNPKHAQL------VREKYESFEDPAGTIDKFHYGTHYSNAAGVMHY 2169
FRDL K +N QL R+ + + AG + H H S+ + Y
Sbjct: 394 -GRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVA--GGAGGGEPPHVPHHISDVLSDITY 450
Query: 2170 LIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVK--------ELIPEFFY 2221
+ T V C V A W+ E PA ++ E IPEF+
Sbjct: 451 YVYKARRTPRSVL-------CGH-----VRAQWEPH-EYPASMERMQNWTPDECIPEFYT 497
Query: 2222 FPDFLENQNGFDLGCLQLTNEKVGDVVLPPWASSPEDFIQQHRQALESEYVSAHLHEWID 2281
P + + + D+ +P W SS ++F+ HR LES VS LH WID
Sbjct: 498 DPSIFRS-----------IHPDMPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWID 546
Query: 2282 LIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVTDERERKALEGIISNFGQTPCQLLKEP 2341
L FGYK +G A + NV H+ D A G++ QL +P
Sbjct: 547 LTFGYKLQGKEAVKEKNVCL-----------HLVDAHTHLASYGVV--------QLFDQP 587
Query: 2342 HPTRLSAEEA 2351
HP RL+ A
Sbjct: 588 HPQRLAGAPA 597
Score = 32.7 bits (73), Expect = 5.1
Identities = 57/236 (24%), Positives = 84/236 (35%), Gaps = 38/236 (16%)
Query: 2452 GPWVPGSGVSGQALAVAPDGKLL----------FSGG---HWDGSLRVTALPRGKLLSQL 2498
GP P SGV G L D L SG +W + V+ Q+
Sbjct: 1580 GPLGPISGVGGGGLGSGSDDNALKQELPRSVHGLSGNWLAYWQYEIGVSQQDAHFHFHQI 1639
Query: 2499 SC-----HLDVVTCLALDTCGIYLISGSRDTTCMVWRLLHQGGLSVGLAPKPVQVLYGHG 2553
H V C+A + + +SGS+D T +W L + G + AP+ V H
Sbjct: 1640 RLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGDGTSETAPRLVYT--QHR 1697
Query: 2554 AAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQFVAALRPLG--------ATFPGPIFHL 2605
+V V VS DG V + G+ + + PL A P P +
Sbjct: 1698 KSVFFVGQLEAPQHVVSC--DGAVHVWDPFTGKTLRTVEPLDSRVPLTAVAVMPAPHTSI 1755
Query: 2606 ALGSEGQIVVQSSAWERPGAQVTYSLHLYSVNGKLRASL--PLAEQPTALTVTEDF 2659
+ S ++ +PG Q H + + G L L LA P+ +V F
Sbjct: 1756 TMASSDS-TLRFVDCRKPGLQ-----HEFRLGGGLNPGLVRALAISPSGRSVVAGF 1805
>gi|239751186 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 2240
Score = 107 bits (267), Expect = 2e-22
Identities = 97/310 (31%), Positives = 131/310 (42%), Gaps = 68/310 (21%)
Query: 2056 QEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSN 2115
QE LR+ L WV ISNF YLMQLN +AGR D + +PV PWV+ D+ +P
Sbjct: 641 QEELRS--LVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV-DFTTPH----- 692
Query: 2116 PAVFRDLSKPIGVVNPKHAQL------VREKYESFEDPAGTIDKFHYGTHYSNAAGVMHY 2169
FRDL K +N QL R+ + + AG + H H S+ + Y
Sbjct: 693 -GRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVA--GGAGGGEPPHVPHHISDVLSDITY 749
Query: 2170 LIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVK--------ELIPEFFY 2221
+ T V C V A W+ E PA ++ E IPEF+
Sbjct: 750 YVYKARRTPRSVL-------CGH-----VRAQWEPH-EYPASMERMQNWTPDECIPEFYT 796
Query: 2222 FPDFLENQNGFDLGCLQLTNEKVGDVVLPPWASSPEDFIQQHRQALESEYVSAHLHEWID 2281
P + + + D+ +P W SS ++F+ HR LES VS LH WID
Sbjct: 797 DPSIFRS-----------IHPDMPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWID 845
Query: 2282 LIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVTDERERKALEGIISNFGQTPCQLLKEP 2341
L FGYK +G A + NV H+ D A G++ QL +P
Sbjct: 846 LTFGYKLQGKEAVKEKNVCL-----------HLVDAHTHLASYGVV--------QLFDQP 886
Query: 2342 HPTRLSAEEA 2351
HP RL+ A
Sbjct: 887 HPQRLAGAPA 896
Score = 32.7 bits (73), Expect = 5.1
Identities = 57/236 (24%), Positives = 84/236 (35%), Gaps = 38/236 (16%)
Query: 2452 GPWVPGSGVSGQALAVAPDGKLL----------FSGG---HWDGSLRVTALPRGKLLSQL 2498
GP P SGV G L D L SG +W + V+ Q+
Sbjct: 1879 GPLGPISGVGGGGLGSGSDDNALKQELPRSVHGLSGNWLAYWQYEIGVSQQDAHFHFHQI 1938
Query: 2499 SC-----HLDVVTCLALDTCGIYLISGSRDTTCMVWRLLHQGGLSVGLAPKPVQVLYGHG 2553
H V C+A + + +SGS+D T +W L + G + AP+ V H
Sbjct: 1939 RLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGDGTSETAPRLVYT--QHR 1996
Query: 2554 AAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQFVAALRPLG--------ATFPGPIFHL 2605
+V V VS DG V + G+ + + PL A P P +
Sbjct: 1997 KSVFFVGQLEAPQHVVSC--DGAVHVWDPFTGKTLRTVEPLDSRVPLTAVAVMPAPHTSI 2054
Query: 2606 ALGSEGQIVVQSSAWERPGAQVTYSLHLYSVNGKLRASL--PLAEQPTALTVTEDF 2659
+ S ++ +PG Q H + + G L L LA P+ +V F
Sbjct: 2055 TMASSDS-TLRFVDCRKPGLQ-----HEFRLGGGLNPGLVRALAISPSGRSVVAGF 2104
>gi|239745674 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 1941
Score = 107 bits (267), Expect = 2e-22
Identities = 97/310 (31%), Positives = 131/310 (42%), Gaps = 68/310 (21%)
Query: 2056 QEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSN 2115
QE LR+ L WV ISNF YLMQLN +AGR D + +PV PWV+ D+ +P
Sbjct: 342 QEELRS--LVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV-DFTTPH----- 393
Query: 2116 PAVFRDLSKPIGVVNPKHAQL------VREKYESFEDPAGTIDKFHYGTHYSNAAGVMHY 2169
FRDL K +N QL R+ + + AG + H H S+ + Y
Sbjct: 394 -GRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVA--GGAGGGEPPHVPHHISDVLSDITY 450
Query: 2170 LIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVK--------ELIPEFFY 2221
+ T V C V A W+ E PA ++ E IPEF+
Sbjct: 451 YVYKARRTPRSVL-------CGH-----VRAQWEPH-EYPASMERMQNWTPDECIPEFYT 497
Query: 2222 FPDFLENQNGFDLGCLQLTNEKVGDVVLPPWASSPEDFIQQHRQALESEYVSAHLHEWID 2281
P + + + D+ +P W SS ++F+ HR LES VS LH WID
Sbjct: 498 DPSIFRS-----------IHPDMPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWID 546
Query: 2282 LIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVTDERERKALEGIISNFGQTPCQLLKEP 2341
L FGYK +G A + NV H+ D A G++ QL +P
Sbjct: 547 LTFGYKLQGKEAVKEKNVCL-----------HLVDAHTHLASYGVV--------QLFDQP 587
Query: 2342 HPTRLSAEEA 2351
HP RL+ A
Sbjct: 588 HPQRLAGAPA 597
Score = 32.7 bits (73), Expect = 5.1
Identities = 57/236 (24%), Positives = 84/236 (35%), Gaps = 38/236 (16%)
Query: 2452 GPWVPGSGVSGQALAVAPDGKLL----------FSGG---HWDGSLRVTALPRGKLLSQL 2498
GP P SGV G L D L SG +W + V+ Q+
Sbjct: 1580 GPLGPISGVGGGGLGSGSDDNALKQELPRSVHGLSGNWLAYWQYEIGVSQQDAHFHFHQI 1639
Query: 2499 SC-----HLDVVTCLALDTCGIYLISGSRDTTCMVWRLLHQGGLSVGLAPKPVQVLYGHG 2553
H V C+A + + +SGS+D T +W L + G + AP+ V H
Sbjct: 1640 RLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGDGTSETAPRLVYT--QHR 1697
Query: 2554 AAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQFVAALRPLG--------ATFPGPIFHL 2605
+V V VS DG V + G+ + + PL A P P +
Sbjct: 1698 KSVFFVGQLEAPQHVVSC--DGAVHVWDPFTGKTLRTVEPLDSRVPLTAVAVMPAPHTSI 1755
Query: 2606 ALGSEGQIVVQSSAWERPGAQVTYSLHLYSVNGKLRASL--PLAEQPTALTVTEDF 2659
+ S ++ +PG Q H + + G L L LA P+ +V F
Sbjct: 1756 TMASSDS-TLRFVDCRKPGLQ-----HEFRLGGGLNPGLVRALAISPSGRSVVAGF 1805
>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
Length = 404
Score = 56.2 bits (134), Expect = 4e-07
Identities = 38/112 (33%), Positives = 57/112 (50%), Gaps = 9/112 (8%)
Query: 2473 LLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCG-IYLISGSRDTTCMVWRL 2531
L+ + G DG +++ + G LL LS H DVV L+ G + L+S SRD T +W L
Sbjct: 124 LVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDL 183
Query: 2532 LHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVIIHTVR 2583
G K +QVL GH V C +IS + M S + + +V + ++R
Sbjct: 184 NKHG--------KQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMR 227
>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sapiens]
Length = 2161
Score = 50.8 bits (120), Expect = 2e-05
Identities = 37/106 (34%), Positives = 50/106 (47%), Gaps = 13/106 (12%)
Query: 1300 GSPPPSSPESPTSPKPAPPKPPTESPAEPSDVFLPS---EAPCPDPDGFYHALSPFCTPF 1356
G PP SP SP SP+P P +P+E + + +P+ +AP G + T
Sbjct: 1125 GLPPAPSPTSPASPQPPPA---VAAPSEKNSIPIPTIIIKAPSTSSSG--RSSQGSSTEA 1179
Query: 1357 DLGLERSSVGSGNTAGGGGSSGTLTPASQPGTPSPLDGPRPFPAAP 1402
+ + G G GGGGSS + PA P PSP P P PA+P
Sbjct: 1180 EPPTQPEPTGGG---GGGGSSPSPAPAMSPVPPSP--SPVPTPASP 1220
Score = 39.7 bits (91), Expect = 0.042
Identities = 40/136 (29%), Positives = 52/136 (38%), Gaps = 16/136 (11%)
Query: 1302 PPP-------SSPESPTSPKPAPPKPPTESPAEPSDVFLPSEAPCPDPDGFYHALSPFCT 1354
PPP PESP +P P P P T +PA P P P + + T
Sbjct: 1568 PPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPVPPPAVAAAPPT--LDSTASSLT 1625
Query: 1355 PFDLGLERSSVGSGNTAGGGGSSGTLTPASQPGTPSPLDGPRPFPAAPGRHSSSLSNVLE 1414
+D E +++ G +A G PA P P+P P+P P P S + V
Sbjct: 1626 SYD--SEVATLTQGASAAPGDPHPPGPPA--PAAPAPA-APQPGPDPPPGTDSGIEEVDS 1680
Query: 1415 DGSLPEP--TISGDDT 1428
S P TIS T
Sbjct: 1681 RSSSDHPLETISSAST 1696
Score = 37.7 bits (86), Expect = 0.16
Identities = 26/84 (30%), Positives = 34/84 (40%), Gaps = 8/84 (9%)
Query: 1296 AATAGSPPPSSPESPTSPKPAPPKP-PTESPAEPSDVFLPSEAPCPDPDGFYHALSPFCT 1354
+A G P P P +P +P PA P+P P P S + D H L +
Sbjct: 1639 SAAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEVDSRSSSD-----HPLETISS 1693
Query: 1355 PFDLGLERSSVGSGNTAGGGGSSG 1378
L S G +AGGGG +G
Sbjct: 1694 AST--LSSLSAEGGGSAGGGGGAG 1715
Score = 35.0 bits (79), Expect = 1.0
Identities = 35/124 (28%), Positives = 46/124 (37%), Gaps = 13/124 (10%)
Query: 1298 TAGSPPPSSPESPTSPKPAPPKPPTESPAEPSD--------VFLPSEAPCPD-PDGFYHA 1348
T+G PPS + P P P+P + SP P + LP AP D DG +
Sbjct: 1505 TSGRGPPSE-DGPGVPPPSPRRSVPPSPTSPRASEENGLPLLVLPPPAPSVDVEDGEFLF 1563
Query: 1349 LSPFCTPFDLGLERSSVGSGNTAGGGGSSGTLTPASQPGTPSPLDGPRPFPAAPGRHSSS 1408
+ P P + S T G L P TP P P AAP S+
Sbjct: 1564 VEPLPPPLEFSNSFEKPESPLTP---GPPHPLPDTPAPATPLPPVPPPAVAAAPPTLDST 1620
Query: 1409 LSNV 1412
S++
Sbjct: 1621 ASSL 1624
Score = 33.5 bits (75), Expect = 3.0
Identities = 34/116 (29%), Positives = 41/116 (35%), Gaps = 36/116 (31%)
Query: 1304 PSSPESPTSPKPAPPKPPTESPAEPSDVFLPSEAPCPDPDGFYHALSPFCTPFDLGLERS 1363
P S + P P +PP+PP +P PS S P P G PF+ G
Sbjct: 915 PGSEDIPPPPTTSPPEPPYSTPPVPSS----SGRLTPSPRG---------GPFNPG---- 957
Query: 1364 SVGSGNTAGGGGSSGTLTPASQPGTPSPLDGPRPFPAAPGRHSSSLSNVLEDGSLP 1419
SG PAS +P+ DGP P G SL G LP
Sbjct: 958 -------------SGGPLPAS---SPASFDGPSPPDTRVGSREKSL---YHSGPLP 994
Score = 33.5 bits (75), Expect = 3.0
Identities = 34/125 (27%), Positives = 47/125 (37%), Gaps = 19/125 (15%)
Query: 1295 EAATAGSPPPSSPESP-------TSPKPAPPKPPTESPAEPSDVFLPSEAPCPDPDGFYH 1347
+ ++ + PP+ PE +SP PAP P P PS V P+ P
Sbjct: 1173 QGSSTEAEPPTQPEPTGGGGGGGSSPSPAPAMSPV--PPSPSPVPTPASPSGP------- 1223
Query: 1348 ALSPFCTPFDLGLERSSVGSGNTAGGGGSSGTLTPASQPGTPSPLDGPRPFPAAPG---R 1404
A F + F L ++ G TL ++ G DG AAPG R
Sbjct: 1224 ATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPGPRLR 1283
Query: 1405 HSSSL 1409
HS S+
Sbjct: 1284 HSKSI 1288
>gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens]
Length = 919
Score = 49.7 bits (117), Expect = 4e-05
Identities = 40/128 (31%), Positives = 63/128 (49%), Gaps = 16/128 (12%)
Query: 2471 GKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLI-SGSRDTTCMVW 2529
G +L S G D ++ T RG+ L LS H + LAL T ++I SGS+D T W
Sbjct: 724 GAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI--LALYTWSGWMIASGSQDKTVRFW 781
Query: 2530 RLLHQGGLSVGLAPKPVQVL----YGHGAAVSCVAISTELDMAVSGSEDGTVIIHTVRRG 2585
L P V+V+ +G G+AV+ VA+ + +G ED + +++ +R G
Sbjct: 782 DLR---------VPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGG 832
Query: 2586 QFVAALRP 2593
+ V + P
Sbjct: 833 RMVQSYHP 840
Score = 35.4 bits (80), Expect = 0.78
Identities = 36/125 (28%), Positives = 56/125 (44%), Gaps = 6/125 (4%)
Query: 2457 GSGVSGQALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIY 2516
G+G + ++AV P G+LL +G D S + + G+++ H V + Y
Sbjct: 798 GTGSAVASVAVDPSGRLLATGQE-DSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHY 856
Query: 2517 LISGSRDTTCMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGT 2576
L++GS D V L QG L+ L P+ V+ H V T+ +S S D T
Sbjct: 857 LLTGSYDMKIKVTDL--QGDLTKQL---PIMVVGEHKDKVIQCRWHTQDLSFLSSSADRT 911
Query: 2577 VIIHT 2581
V + T
Sbjct: 912 VTLWT 916
>gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens]
Length = 927
Score = 49.7 bits (117), Expect = 4e-05
Identities = 40/128 (31%), Positives = 63/128 (49%), Gaps = 16/128 (12%)
Query: 2471 GKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLI-SGSRDTTCMVW 2529
G +L S G D ++ T RG+ L LS H + LAL T ++I SGS+D T W
Sbjct: 732 GAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI--LALYTWSGWMIASGSQDKTVRFW 789
Query: 2530 RLLHQGGLSVGLAPKPVQVL----YGHGAAVSCVAISTELDMAVSGSEDGTVIIHTVRRG 2585
L P V+V+ +G G+AV+ VA+ + +G ED + +++ +R G
Sbjct: 790 DLR---------VPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGG 840
Query: 2586 QFVAALRP 2593
+ V + P
Sbjct: 841 RMVQSYHP 848
Score = 35.4 bits (80), Expect = 0.78
Identities = 36/125 (28%), Positives = 56/125 (44%), Gaps = 6/125 (4%)
Query: 2457 GSGVSGQALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIY 2516
G+G + ++AV P G+LL +G D S + + G+++ H V + Y
Sbjct: 806 GTGSAVASVAVDPSGRLLATGQE-DSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHY 864
Query: 2517 LISGSRDTTCMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGT 2576
L++GS D V L QG L+ L P+ V+ H V T+ +S S D T
Sbjct: 865 LLTGSYDMKIKVTDL--QGDLTKQL---PIMVVGEHKDKVIQCRWHTQDLSFLSSSADRT 919
Query: 2577 VIIHT 2581
V + T
Sbjct: 920 VTLWT 924
>gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens]
Length = 920
Score = 49.7 bits (117), Expect = 4e-05
Identities = 40/128 (31%), Positives = 63/128 (49%), Gaps = 16/128 (12%)
Query: 2471 GKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLI-SGSRDTTCMVW 2529
G +L S G D ++ T RG+ L LS H + LAL T ++I SGS+D T W
Sbjct: 725 GAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI--LALYTWSGWMIASGSQDKTVRFW 782
Query: 2530 RLLHQGGLSVGLAPKPVQVL----YGHGAAVSCVAISTELDMAVSGSEDGTVIIHTVRRG 2585
L P V+V+ +G G+AV+ VA+ + +G ED + +++ +R G
Sbjct: 783 DLR---------VPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGG 833
Query: 2586 QFVAALRP 2593
+ V + P
Sbjct: 834 RMVQSYHP 841
Score = 35.4 bits (80), Expect = 0.78
Identities = 36/125 (28%), Positives = 56/125 (44%), Gaps = 6/125 (4%)
Query: 2457 GSGVSGQALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIY 2516
G+G + ++AV P G+LL +G D S + + G+++ H V + Y
Sbjct: 799 GTGSAVASVAVDPSGRLLATGQE-DSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHY 857
Query: 2517 LISGSRDTTCMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGT 2576
L++GS D V L QG L+ L P+ V+ H V T+ +S S D T
Sbjct: 858 LLTGSYDMKIKVTDL--QGDLTKQL---PIMVVGEHKDKVIQCRWHTQDLSFLSSSADRT 912
Query: 2577 VIIHT 2581
V + T
Sbjct: 913 VTLWT 917
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 49.7 bits (117), Expect = 4e-05
Identities = 48/159 (30%), Positives = 74/159 (46%), Gaps = 20/159 (12%)
Query: 2421 SWLPYDRNISNYFSFSK----DPTMGSHKTQRLLSG--PWVPGSGVSGQALAVAPDGKLL 2474
SW P R +++ + DP+ G + R L+G W+ +G+S + L P+ + +
Sbjct: 163 SWSPDGRKLASGCKNGQILLWDPSTGK-QVGRTLAGHSKWI--TGLSWEPLHANPECRYV 219
Query: 2475 FSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWRLLHQ 2534
S DGS+R+ G+ L+ H VTCL G+ L S S+D T VWR H
Sbjct: 220 ASSSK-DGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVWR-AHD 276
Query: 2535 GGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSE 2573
G L + L GHG V+ +A+ST+ + E
Sbjct: 277 GVL--------CRTLQGHGHWVNTMALSTDYALRTGAFE 307
Score = 38.5 bits (88), Expect = 0.092
Identities = 27/103 (26%), Positives = 51/103 (49%), Gaps = 12/103 (11%)
Query: 2517 LISGSRDTTCMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGT 2576
L+SGS D T +W S KP+ + GH A ++ V S + + S S D +
Sbjct: 344 LVSGSDDFTLFLW--------SPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKS 395
Query: 2577 VIIHTVRRGQFVAALRPLGATFPGPIFHLALGSEGQIVVQSSA 2619
+ + R G+++A+LR A ++ +A ++ +++V S+
Sbjct: 396 IKLWDGRTGKYLASLRGHVAA----VYQIAWSADSRLLVSGSS 434
Score = 37.0 bits (84), Expect = 0.27
Identities = 31/107 (28%), Positives = 47/107 (43%), Gaps = 10/107 (9%)
Query: 2468 APDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCM 2527
+PD +++ S +D S+++ GK L+ L H+ V +A L+SGS D+T
Sbjct: 381 SPDSRIVASAS-FDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLK 439
Query: 2528 VWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSED 2574
VW + A K L GH V V S + SG +D
Sbjct: 440 VWDV---------KAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKD 477
Score = 34.3 bits (77), Expect = 1.7
Identities = 29/105 (27%), Positives = 45/105 (42%), Gaps = 3/105 (2%)
Query: 2426 DRNISNYFSFSKDPTMGSHKTQRLLSGPWVPGSGVSGQALAVAPDGKLLFSGGHWDGSLR 2485
D I SF K + +T + L+ + G + +A + D +LL SG D +L+
Sbjct: 383 DSRIVASASFDKSIKLWDGRTGKYLAS--LRGHVAAVYQIAWSADSRLLVSGSS-DSTLK 439
Query: 2486 VTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWR 2530
V + KL L H D V + G + SG +D +WR
Sbjct: 440 VWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Score = 33.9 bits (76), Expect = 2.3
Identities = 30/104 (28%), Positives = 43/104 (41%), Gaps = 11/104 (10%)
Query: 2485 RVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWRLLHQGGLSVGLAPK 2544
RV A+ R S L H + V +A G YL SGS DTT W L +
Sbjct: 99 RVRAVTR--CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTE---------T 147
Query: 2545 PVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQFV 2588
P GH V ++ S + SG ++G +++ G+ V
Sbjct: 148 PHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQV 191
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 49.3 bits (116), Expect = 5e-05
Identities = 35/113 (30%), Positives = 56/113 (49%), Gaps = 10/113 (8%)
Query: 2465 LAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDT 2524
L +PDG L + G+ DGS+R+ +L G+ + H +T L D G L SGS+DT
Sbjct: 71 LCPSPDG-LHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDT 129
Query: 2525 TCMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTV 2577
+VW ++++ GL L GH A++ E ++ V+ +D V
Sbjct: 130 DIIVWDVINESGL---------YRLKGHKDAITQALFLREKNLLVTSGKDTMV 173
>gi|31657103 WD repeat domain 23 isoform 1 [Homo sapiens]
Length = 546
Score = 48.9 bits (115), Expect = 7e-05
Identities = 36/124 (29%), Positives = 57/124 (45%), Gaps = 10/124 (8%)
Query: 2464 ALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLAL-DTCGIYLISGSR 2522
++AV+ DG+ + G + DG L V + + Q+ H D V +A D L SG
Sbjct: 270 SIAVSSDGREVLGGAN-DGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGD 328
Query: 2523 DTTCMVW--RLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVIIH 2580
D C VW R + + PKPV L GH ++ + + +S S+D T+ +
Sbjct: 329 DAICKVWDRRTMREDD------PKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLW 382
Query: 2581 TVRR 2584
+RR
Sbjct: 383 DIRR 386
>gi|31657101 WD repeat domain 23 isoform 2 [Homo sapiens]
Length = 520
Score = 48.9 bits (115), Expect = 7e-05
Identities = 36/124 (29%), Positives = 57/124 (45%), Gaps = 10/124 (8%)
Query: 2464 ALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLAL-DTCGIYLISGSR 2522
++AV+ DG+ + G + DG L V + + Q+ H D V +A D L SG
Sbjct: 244 SIAVSSDGREVLGGAN-DGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGD 302
Query: 2523 DTTCMVW--RLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVIIH 2580
D C VW R + + PKPV L GH ++ + + +S S+D T+ +
Sbjct: 303 DAICKVWDRRTMREDD------PKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLW 356
Query: 2581 TVRR 2584
+RR
Sbjct: 357 DIRR 360
>gi|21536485 HIR histone cell cycle regulation defective homolog A
[Homo sapiens]
Length = 1017
Score = 48.9 bits (115), Expect = 7e-05
Identities = 47/170 (27%), Positives = 66/170 (38%), Gaps = 25/170 (14%)
Query: 2448 RLLSGPWVPGSGVSGQALAVAPDGKLLFSGGHWDGSLRVTALPRG--------------K 2493
+LL WV +G ++ + PDG +GG S +V K
Sbjct: 2 KLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPK 61
Query: 2494 LLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWRLLHQGGLSVGLAP---------- 2543
+L Q+ HL V C+ G+YL SG D MVW+ G S
Sbjct: 62 MLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQW 121
Query: 2544 KPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVII-HTVRRGQFVAALR 2592
+ V +L H V VA S S S D TV+I + V+ + +A LR
Sbjct: 122 RCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLR 171
>gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens]
Length = 919
Score = 48.5 bits (114), Expect = 9e-05
Identities = 66/272 (24%), Positives = 110/272 (40%), Gaps = 45/272 (16%)
Query: 2407 LLVTVSASGLLGTHSWLPYDRNISNYFSFSKDP-------------TMGSHKTQRLLSGP 2453
LLVT ASG+ H LP + N+ + S S G +LL
Sbjct: 302 LLVTGFASGIFHLHE-LP-EFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWE 359
Query: 2454 WVPGSGVSGQ--------ALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVV 2505
W S V Q ALA +PDG+ + +GG DG ++V G + H V
Sbjct: 360 WQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGD-DGKVKVWNTLSGFCFVTFTEHSSGV 418
Query: 2506 TCLALDTCGIYLISGSRDTTCMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTEL 2565
T + G +++ S D T + L +P+P Q SCVA+
Sbjct: 419 TGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQ--------FSCVAVDASG 470
Query: 2566 DMAVSGSEDG-TVIIHTVRRGQFVAALRPLGATFPGPIFHLALGSEGQIVVQSSAWERPG 2624
++ +G++D + + +++ G+ + L + GPI L + + V+ S++W++
Sbjct: 471 EIVSAGAQDSFEIFVWSMQTGRLLDVL----SGHEGPISGLCF-NPMKSVLASASWDK-- 523
Query: 2625 AQVTYSLHLYSVNGKLRASLPLAEQPTALTVT 2656
++ L+ + R LA AL VT
Sbjct: 524 -----TVRLWDMFDSWRTKETLALTSDALAVT 550
>gi|22027541 programmed cell death 7 [Homo sapiens]
Length = 485
Score = 48.5 bits (114), Expect = 9e-05
Identities = 38/101 (37%), Positives = 44/101 (43%), Gaps = 15/101 (14%)
Query: 1300 GSPPPSSPESPTSPKPAPPKPPTESPAEPSDVFLPSEAPCPD-PDGFYHALSPFCTPFDL 1358
G PPP P P +P PP PP SPA P P P P F A +PF P L
Sbjct: 13 GPPPPQPP--PPAPFGCPP-PPLPSPAFP--------PPLPQRPGPFPGASAPFLQP-PL 60
Query: 1359 GLERSSVGSGNTAGGGGSSGTLTPASQPGTPSPLDGPRPFP 1399
L+ + S + GGG +G P P P P RPFP
Sbjct: 61 ALQPRA--SAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFP 99
>gi|28872796 CCAAT/enhancer binding protein beta [Homo sapiens]
Length = 345
Score = 47.4 bits (111), Expect = 2e-04
Identities = 33/93 (35%), Positives = 39/93 (41%), Gaps = 10/93 (10%)
Query: 1309 SPTSPKPAPPKPPTESPAEP----SDVFLPSEAPCPDPDGFYHALSPFCTPFDLGLERSS 1364
+P P P PP PP E AEP +D EA P A P+ LG +
Sbjct: 158 APLHPPPPPPPPPAELKAEPGFEPADCKRKEEAGAPGGGAGMAAGFPYALRAYLGYQAVP 217
Query: 1365 VGSGNTAGGGGSSGTLTPASQPGTPSPLDGPRP 1397
GS GS T + +S PGTPSP D P
Sbjct: 218 SGSS------GSLSTSSSSSPPGTPSPADAKAP 244
>gi|110556644 zinc finger protein, multitype 1 [Homo sapiens]
Length = 1006
Score = 47.0 bits (110), Expect = 3e-04
Identities = 42/122 (34%), Positives = 49/122 (40%), Gaps = 35/122 (28%)
Query: 1297 ATAGSPPPSSPESPTSPKPAPPKPPTESPAEPSDV--------FLPSEAPCPDPDGFYHA 1348
A+ PPP P +P P P P PP SPA P + AP P P G HA
Sbjct: 707 ASRHDPPPRRPAAPPGP-PGPAAPPAPSPAAPVRTRRRRKLYELHAAGAPPPPPPG--HA 763
Query: 1349 LSPFCTPFDLGLERSSVGSGNTAGGGGSSGTLTPASQPGTPSPLDGP--------RPFPA 1400
+P E GSG+ +G G L PA PG + DGP RP P
Sbjct: 764 PAP---------ESPRPGSGSGSGPG-----LAPARSPGPAA--DGPIDLSKKPRRPLPG 807
Query: 1401 AP 1402
AP
Sbjct: 808 AP 809
Score = 33.5 bits (75), Expect = 3.0
Identities = 21/55 (38%), Positives = 29/55 (52%), Gaps = 6/55 (10%)
Query: 1290 RLYVLEAATAGSPPPSSPESPTSPKPAPPKPPTESPAEPSDVFLPSEAPCPDPDG 1344
+LY L AA G+PPP P +P P P+P + S + P P+ +P P DG
Sbjct: 745 KLYELHAA--GAPPPPPPGH--APAPESPRPGSGSGSGPG--LAPARSPGPAADG 793
Score = 33.1 bits (74), Expect = 3.9
Identities = 17/44 (38%), Positives = 20/44 (45%), Gaps = 1/44 (2%)
Query: 1302 PPPSSPESPTSPKPAPPKPPTESPAEPSDVFLPSE-APCPDPDG 1344
PPP P SP + A P PP V PS+ P P P+G
Sbjct: 928 PPPGPPPSPAAAPEAVPPPPAPPSYSDKGVQTPSKGTPAPLPNG 971
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 46.6 bits (109), Expect = 3e-04
Identities = 30/114 (26%), Positives = 53/114 (46%), Gaps = 9/114 (7%)
Query: 2478 GHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWRLLHQGGL 2537
G +D + ++ ++ GK H + CL+ + + +GS DTT +W + Q G
Sbjct: 153 GSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI--QNG- 209
Query: 2538 SVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQFVAAL 2591
+ V L GH A + ++ +T D ++GS D TV++ G+ V L
Sbjct: 210 ------EEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNIL 257
Score = 43.1 bits (100), Expect = 0.004
Identities = 31/118 (26%), Positives = 55/118 (46%), Gaps = 9/118 (7%)
Query: 2474 LFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWRLLH 2533
L + G D + ++ + G+ + L H + L+ +T G +I+GS D T +VW
Sbjct: 191 LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW---- 246
Query: 2534 QGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQFVAAL 2591
G + V +L GH A +S + + + + ++GS D T + G+ VA L
Sbjct: 247 --DADTG---RKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATL 299
Score = 40.4 bits (93), Expect = 0.024
Identities = 28/106 (26%), Positives = 55/106 (51%), Gaps = 10/106 (9%)
Query: 2471 GKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWR 2530
GKL+ + DG+ R+ + K +++L H ++ ++ + G +L++GS D T +W
Sbjct: 315 GKLIATASA-DGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
Query: 2531 LLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGT 2576
Q G + +QVL GH + A + + ++ ++GS+D T
Sbjct: 374 A--QTG-------QCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNT 410
Score = 39.3 bits (90), Expect = 0.054
Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 1/62 (1%)
Query: 2469 PDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMV 2528
P G L +G D + R+ G+ L L H D + A + G +I+GS+D TC +
Sbjct: 355 PQGNHLLTGSS-DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRI 413
Query: 2529 WR 2530
WR
Sbjct: 414 WR 415
Score = 37.0 bits (84), Expect = 0.27
Identities = 34/141 (24%), Positives = 59/141 (41%), Gaps = 13/141 (9%)
Query: 2478 GHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWRLLHQGGL 2537
G D + ++ GK ++ L+ H D + D G + + S D T ++ +
Sbjct: 279 GSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATR--- 335
Query: 2538 SVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQFVAALRPLGAT 2597
K + L GH +S ++ + + + ++GS D T I + GQ + L G T
Sbjct: 336 ------KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLE--GHT 387
Query: 2598 FPGPIFHLALGSEGQIVVQSS 2618
IF A +G IV+ S
Sbjct: 388 --DEIFSCAFNYKGNIVITGS 406
Score = 36.6 bits (83), Expect = 0.35
Identities = 35/145 (24%), Positives = 58/145 (40%), Gaps = 12/145 (8%)
Query: 2494 LLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWRLLHQGGLSVGLAPKPVQVLYGHG 2553
L L H+ +T +AL+ G I+GS D TC +W + + + L GH
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDT---------ASGEELNTLEGHR 134
Query: 2554 AAVSCVAISTEL-DMAVSGSEDGTVIIHTVRRGQFVAALRPLGATFPGPIFH--LALGSE 2610
V +A + D +GS D T + +V G+ R A F+ L +
Sbjct: 135 NVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVAT 194
Query: 2611 GQIVVQSSAWERPGAQVTYSLHLYS 2635
G + + W+ + Y+L +S
Sbjct: 195 GSMDTTAKLWDIQNGEEVYTLRGHS 219
>gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]
Length = 797
Score = 46.6 bits (109), Expect = 3e-04
Identities = 22/53 (41%), Positives = 31/53 (58%)
Query: 2479 HWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWRL 2531
H D ++ GK++ + HLD VT LA+D GIYL+SGS D + +W L
Sbjct: 700 HEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNL 752
Score = 34.3 bits (77), Expect = 1.7
Identities = 24/82 (29%), Positives = 33/82 (40%), Gaps = 2/82 (2%)
Query: 2498 LSCHLDVVTCLALDTCGIYLISGSRDTTCMVWRLLH--QGGLSVGLAPKPVQVLYGHGAA 2555
L H D V LA L++ S D T +W L S L +P+ H
Sbjct: 476 LRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGP 535
Query: 2556 VSCVAISTELDMAVSGSEDGTV 2577
V +AIS+ + SG D T+
Sbjct: 536 VLSLAISSNGEQCFSGGIDATI 557
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 117,082,124
Number of Sequences: 37866
Number of extensions: 6093092
Number of successful extensions: 43202
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 165
Number of HSP's successfully gapped in prelim test: 666
Number of HSP's that attempted gapping in prelim test: 31726
Number of HSP's gapped (non-prelim): 8835
length of query: 2754
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2634
effective length of database: 13,703,598
effective search space: 36095277132
effective search space used: 36095277132
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.