Search of human proteins with 148886752

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148886752 immunoglobulin superfamily, member 9B [Homo
sapiens]
         (1349 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens]    2771   0.0  
gi|205277425 immunoglobulin superfamily, member 9 isoform a [Hom...   760   0.0  
gi|205277423 immunoglobulin superfamily, member 9 isoform b [Hom...   733   0.0  
gi|118572606 hemicentin 1 [Homo sapiens]                              165   3e-40
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...   155   2e-37
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor...   155   2e-37
gi|19743806 roundabout 1 isoform b [Homo sapiens]                     154   6e-37
gi|4506569 roundabout 1 isoform a [Homo sapiens]                      154   6e-37
gi|83281200 protogenin [Homo sapiens]                                 153   9e-37
gi|7657361 contactin 6 [Homo sapiens]                                 152   2e-36
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]        152   2e-36
gi|224994173 roundabout 1 isoform d [Homo sapiens]                    151   5e-36
gi|224994171 roundabout 1 isoform c [Homo sapiens]                    151   5e-36
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ...   151   5e-36
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ...   151   5e-36
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   150   8e-36
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   150   8e-36
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   150   8e-36
gi|157311649 neogenin homolog 1 [Homo sapiens]                        149   2e-35
gi|81158224 neuronal cell adhesion molecule isoform B precursor ...   146   2e-34
gi|75709184 contactin 3 [Homo sapiens]                                144   4e-34
gi|28373122 contactin 4 isoform a precursor [Homo sapiens]            144   6e-34
gi|81158226 neuronal cell adhesion molecule isoform A precursor ...   143   1e-33
gi|110431348 deleted in colorectal carcinoma [Homo sapiens]           143   1e-33
gi|109150416 peroxidasin [Homo sapiens]                               140   6e-33
gi|126517478 peroxidasin homolog-like [Homo sapiens]                  138   3e-32
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]           137   5e-32
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]            137   5e-32
gi|7657359 contactin 5 isoform long [Homo sapiens]                    137   7e-32
gi|28373129 contactin 5 isoform short [Homo sapiens]                  137   7e-32

>gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens]
          Length = 1349

 Score = 2771 bits (7183), Expect = 0.0
 Identities = 1349/1349 (100%), Positives = 1349/1349 (100%)

Query: 1    MIWYVATFIASVIGTRGLAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVV 60
            MIWYVATFIASVIGTRGLAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVV
Sbjct: 1    MIWYVATFIASVIGTRGLAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVV 60

Query: 61   EWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQ 120
            EWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQ
Sbjct: 61   EWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQ 120

Query: 121  QYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLL 180
            QYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLL
Sbjct: 121  QYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLL 180

Query: 181  GASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITV 240
            GASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITV
Sbjct: 181  GASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITV 240

Query: 241  NISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGK 300
            NISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGK
Sbjct: 241  NISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGK 300

Query: 301  YTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWN 360
            YTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWN
Sbjct: 301  YTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWN 360

Query: 361  KDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPP 420
            KDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPP
Sbjct: 361  KDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPP 420

Query: 421  YFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSK 480
            YFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSK
Sbjct: 421  YFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSK 480

Query: 481  EDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQT 540
            EDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQT
Sbjct: 481  EDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQT 540

Query: 541  FSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVN 600
            FSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVN
Sbjct: 541  FSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVN 600

Query: 601  TLAFPITTPEPLVLVTPPRCLIANRTQQGVLLSWLPPANHSFPIDRYIMEFRVAERWELL 660
            TLAFPITTPEPLVLVTPPRCLIANRTQQGVLLSWLPPANHSFPIDRYIMEFRVAERWELL
Sbjct: 601  TLAFPITTPEPLVLVTPPRCLIANRTQQGVLLSWLPPANHSFPIDRYIMEFRVAERWELL 660

Query: 661  DDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSSTDIFPQPDLTEDGLA 720
            DDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSSTDIFPQPDLTEDGLA
Sbjct: 661  DDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSSTDIFPQPDLTEDGLA 720

Query: 721  RPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSG 780
            RPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSG
Sbjct: 721  RPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSG 780

Query: 781  KVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLYKKTKRAISSKKYSVAKAEAE 840
            KVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLYKKTKRAISSKKYSVAKAEAE
Sbjct: 781  KVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLYKKTKRAISSKKYSVAKAEAE 840

Query: 841  AEATTPIELISRGPDGRFVMDPAEMEPSLKSRRIEGFPFAEETDMYPEFRQSDEENEDPL 900
            AEATTPIELISRGPDGRFVMDPAEMEPSLKSRRIEGFPFAEETDMYPEFRQSDEENEDPL
Sbjct: 841  AEATTPIELISRGPDGRFVMDPAEMEPSLKSRRIEGFPFAEETDMYPEFRQSDEENEDPL 900

Query: 901  VPTSVAALKSQLTPLSSSQESYLPPPAYSPRFQPRGLEGPGGLEGRLQATGQARPPAPRP 960
            VPTSVAALKSQLTPLSSSQESYLPPPAYSPRFQPRGLEGPGGLEGRLQATGQARPPAPRP
Sbjct: 901  VPTSVAALKSQLTPLSSSQESYLPPPAYSPRFQPRGLEGPGGLEGRLQATGQARPPAPRP 960

Query: 961  FHHGQYYGYLSSSSPGEVEPPPFYVPEVGSPLSSVMSSPPLPTEGPFGHPTIPEENGENA 1020
            FHHGQYYGYLSSSSPGEVEPPPFYVPEVGSPLSSVMSSPPLPTEGPFGHPTIPEENGENA
Sbjct: 961  FHHGQYYGYLSSSSPGEVEPPPFYVPEVGSPLSSVMSSPPLPTEGPFGHPTIPEENGENA 1020

Query: 1021 SNSTLPLTQTPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLPPCDVPESLQPKAGLPRGL 1080
            SNSTLPLTQTPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLPPCDVPESLQPKAGLPRGL
Sbjct: 1021 SNSTLPLTQTPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLPPCDVPESLQPKAGLPRGL 1080

Query: 1081 PPTSLQVPAAYPGILSLEAPKGWAGKSPGRGPVPAPPAAKWQDRPMQPLVSQGQLRHTSQ 1140
            PPTSLQVPAAYPGILSLEAPKGWAGKSPGRGPVPAPPAAKWQDRPMQPLVSQGQLRHTSQ
Sbjct: 1081 PPTSLQVPAAYPGILSLEAPKGWAGKSPGRGPVPAPPAAKWQDRPMQPLVSQGQLRHTSQ 1140

Query: 1141 GMGIPVLPYPEPAEPGAHGGPSTFGLDTRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSR 1200
            GMGIPVLPYPEPAEPGAHGGPSTFGLDTRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSR
Sbjct: 1141 GMGIPVLPYPEPAEPGAHGGPSTFGLDTRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSR 1200

Query: 1201 LSPLTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSTGSPSQ 1260
            LSPLTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSTGSPSQ
Sbjct: 1201 LSPLTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSTGSPSQ 1260

Query: 1261 SSRSGSPSYRPAMGFTTLATGYPSPPPGPAPAGPGDSLDVFGQTPSPRRTGEELLRPETP 1320
            SSRSGSPSYRPAMGFTTLATGYPSPPPGPAPAGPGDSLDVFGQTPSPRRTGEELLRPETP
Sbjct: 1261 SSRSGSPSYRPAMGFTTLATGYPSPPPGPAPAGPGDSLDVFGQTPSPRRTGEELLRPETP 1320

Query: 1321 PPTLPTSGKLQRDRPAPATSPPERALSKL 1349
            PPTLPTSGKLQRDRPAPATSPPERALSKL
Sbjct: 1321 PPTLPTSGKLQRDRPAPATSPPERALSKL 1349


>gi|205277425 immunoglobulin superfamily, member 9 isoform a [Homo
            sapiens]
          Length = 1179

 Score =  760 bits (1963), Expect = 0.0
 Identities = 443/1026 (43%), Positives = 578/1026 (56%), Gaps = 69/1026 (6%)

Query: 1    MIWYVATFIASVIGTRGLAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVV 60
            M+W +   + S++ ++G    G    + E   V  RAGESVVL CD++ P  G+PP +V+
Sbjct: 1    MVWCLGLAVLSLVISQGADGRG----KPEVVSVVGRAGESVVLGCDLLPPA-GRPPLHVI 55

Query: 61   EWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQ 120
            EW +FG  +PIFI+FG Y P +DP+Y GR  L   ASL++E +R EDQGWYEC+V  LDQ
Sbjct: 56   EWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQ 115

Query: 121  QY--DTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGT 178
                D F NGSWVHLT+N+PP F ETPP  +E +E   +T+ C A G+P P VTW   G 
Sbjct: 116  HIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGK 175

Query: 179  LLG-ASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPEN 237
             LG   G+ QV +G+L +  V R   G YTC+A S +G A H T LLV GPP IV PP+N
Sbjct: 176  DLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKN 235

Query: 238  ITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPED 297
             TVN SQD  L C AEAYP NLTY+W+  + NV+  + L+ RVRIL+DG+L +   +P+D
Sbjct: 236  STVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDD 295

Query: 298  SGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVV 357
            +G YTCVPSN L   PSASAYLTV YPA+V  MPP   +P+G+ G IRCPV A PP   V
Sbjct: 296  AGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFV 355

Query: 358  KWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLK 417
             W KDG+ LQ++K  GW+   +GS+ I    E+ALG Y+C PYN+LGT G S   R++LK
Sbjct: 356  SWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLK 415

Query: 418  DPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRA 477
             PP F   P  EY QE GRELLIPC+A GDP PV++W KVG+  + +     + SL  R 
Sbjct: 416  APPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRP 475

Query: 478  LSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGY 537
            L+KE HG WEC A+N V  +  ST++ V+GTSPH   +V V      ANVSWEPG+DGGY
Sbjct: 476  LTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGY 535

Query: 538  EQTFSVW----MKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAF 593
             Q FSVW     KR     HDW+SL VP G + LLV  L+P T YQFSVLAQNKLG+  F
Sbjct: 536  LQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPF 595

Query: 594  SEVVTVNTLAFPITTPEPLVLVT-------PPRCLIANRTQQGVLLSWLPPANHSFPIDR 646
            SE+V       P T   P +  T       PPR L+A RT +GVLL W PP      +D 
Sbjct: 596  SEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDG 655

Query: 647  YIMEFRV-AERWELLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSS 705
            Y++E R  ++ WE+LD  + GTE E     L +D  YEFR++A     +S+PSN A VS+
Sbjct: 656  YVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVST 715

Query: 706  T--DIFPQPDLTEDGLARPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKK--- 760
            +  +++P        L +PVLAG+V  +CFL  A+L S LA C +N++R  + +RK+   
Sbjct: 716  SGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQ 775

Query: 761  DPPLSITHCRKSLESPLSSGKVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLY 820
            DPPL  +   KS  +P + G  SP+S+  L+        QG P              SL 
Sbjct: 776  DPPLIFSPTGKS-AAPSALGSGSPDSVAKLKL-------QGSPVP------------SLR 815

Query: 821  KKTKRAISSKKYSVAKAEAEAEATTPIELISRGPDGRFVMDPAEMEPSLKSRRIEGFPFA 880
            +       +   S       +    P+E I RGPDGRFVM P    P  +S R +  P  
Sbjct: 816  QSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRT 875

Query: 881  EETDMYPEFRQSDEENEDPLVPTSVAALKSQLTPLSSSQESYLPPPAYSPRFQPRGLEGP 940
                +   F  S         P  +      ++P++       PPPA      P  L GP
Sbjct: 876  PAQRLARSFDCSSSSPSGAPQPLCI----EDISPVA-------PPPA----APPSPLPGP 920

Query: 941  GGLEGRLQATGQARPPAPRPFHHGQYYGYLSSSSPGEVEPPPFYVPEVGSPLSSVMSSPP 1000
            G L   L        P  R  +    +  L   SP     PP Y+     P SS + SP 
Sbjct: 921  GPLLQYLSL------PFFREMNVDGDWPPLEEPSPA---APPDYMDTRRCPTSSFLRSPE 971

Query: 1001 LPTEGP 1006
             P   P
Sbjct: 972  TPPVSP 977



 Score = 35.4 bits (80), Expect = 0.37
 Identities = 81/314 (25%), Positives = 105/314 (33%), Gaps = 56/314 (17%)

Query: 970  LSSSSPGEVEPPPFYVPEVGSPLSSVMSSPPLPTEGPFGHPTIPEENGENASNSTLPLTQ 1029
            L S SP  V         V S   S++   P  T  P  HP  P   G       LPL  
Sbjct: 793  LGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSP--HPDPPSSRGP------LPLEP 844

Query: 1030 TPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLPPCDVPESLQPKAGLPRGLPPTSLQVPA 1089
               G     P GR  F  G    P +  P +    +  E   P   L R    +S   P+
Sbjct: 845  ICRG-----PDGR--FVMG----PTVAAPQERSGREQAEPRTPAQRLARSFDCSSSS-PS 892

Query: 1090 AYPGILSLEAPKGWAGKSPGRGPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGMGIPVLPY 1149
              P  L +E        SP   P  APP+      P+   +S    R  +     P L  
Sbjct: 893  GAPQPLCIE------DISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEE 946

Query: 1150 PEPAEPGAHGGPSTFGLDTR------WYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSP 1203
            P PA P  +       +DTR      +      P  SPR+      SL   V+     + 
Sbjct: 947  PSPAAPPDY-------MDTRRCPTSSFLRSPETPPVSPRE------SLPGAVVGAGATAE 993

Query: 1204 LTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSTGSPSQSSR 1263
               + L+  T       R R  PGLL  A    +T Q     S  R S      PS +  
Sbjct: 994  PPYTALADWT------LRERLLPGLLPAAPRGSLTSQ-----SSGRGSASFLRPPSTAPS 1042

Query: 1264 SGSPSYRPAMGFTT 1277
            +G     PA G T+
Sbjct: 1043 AGGSYLSPAPGDTS 1056



 Score = 33.1 bits (74), Expect = 1.9
 Identities = 77/307 (25%), Positives = 107/307 (34%), Gaps = 50/307 (16%)

Query: 1061 LPPCDVPESLQPKAGL-----PRGL-----PPTSLQVPAAYPGILSLEAPKGWAGKSPGR 1110
            LPP ++P  L P  GL     PRG+     PP    VP    G + LE  +G  G     
Sbjct: 615  LPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPE--LVPKRLDGYV-LEGRQGSQG----- 666

Query: 1111 GPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGMGIPVLPYPEPAEPGAHGGPSTFGLD--- 1167
              V  P  A  +   + P    G ++       +        ++P      ST GL+   
Sbjct: 667  WEVLDPAVAGTETELLVP----GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYP 722

Query: 1168 TRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSPLTQSPLSSRTGSPELAARARPRPG 1227
            +R   P   P+P           L   VL    +S L    L+ R  +     R R  P 
Sbjct: 723  SRTQLPGLLPQPVLAGVVGGVCFLGVAVL----VSILAGCLLNRRRAARRRRKRLRQDPP 778

Query: 1228 LL-----QQAEMSEITLQPPAAVSFSRKSTPSTGSPSQSSRSGSPSYRPAMGFTTLATGY 1282
            L+     + A  S +    P +V+  +       S  QS   G P+  P        + +
Sbjct: 779  LIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTP--------SPH 830

Query: 1283 PSPPP--GPAPAGP----GDSLDVFGQTPS--PRRTGEELLRPETPPPTLPTSGKLQRDR 1334
            P PP   GP P  P     D   V G T +    R+G E   P TP   L  S       
Sbjct: 831  PDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSS 890

Query: 1335 PAPATSP 1341
            P+ A  P
Sbjct: 891  PSGAPQP 897


>gi|205277423 immunoglobulin superfamily, member 9 isoform b [Homo
            sapiens]
          Length = 1163

 Score =  733 bits (1891), Expect = 0.0
 Identities = 437/1026 (42%), Positives = 568/1026 (55%), Gaps = 85/1026 (8%)

Query: 1    MIWYVATFIASVIGTRGLAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVV 60
            M+W +   + S++ ++G    G    + E   V  RAGESVVL CD++ P  G+PP +V+
Sbjct: 1    MVWCLGLAVLSLVISQGADGRG----KPEVVSVVGRAGESVVLGCDLLPPA-GRPPLHVI 55

Query: 61   EWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQ 120
            EW +FG  +PIFI+FG Y P +DP+Y GR  L   ASL++E +R EDQGWYEC+V  LDQ
Sbjct: 56   EWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQ 115

Query: 121  QY--DTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGT 178
                D F NGSWVHLT+N+PP F ETPP  +E +E   +T+ C A G+P P VTW   G 
Sbjct: 116  HIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGK 175

Query: 179  LLG-ASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPEN 237
             LG   G+ QV +G+L +  V R   G YTC+A S +G A H T LLV GPP IV PP+N
Sbjct: 176  DLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKN 235

Query: 238  ITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPED 297
             TVN SQD  L C AEAYP NLTY+W+  + NV+  + L+ RVRIL+DG+L +   +P+D
Sbjct: 236  STVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDD 295

Query: 298  SGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVV 357
            +G YTCVPSN L   PSASAYLTV      L MP          G IRCPV A PP   V
Sbjct: 296  AGCYTCVPSNGLLHPPSASAYLTV------LCMP----------GVIRCPVRANPPLLFV 339

Query: 358  KWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLK 417
             W KDG+ LQ++K  GW+   +GS+ I    E+ALG Y+C PYN+LGT G S   R++LK
Sbjct: 340  SWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLK 399

Query: 418  DPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRA 477
             PP F   P  EY QE GRELLIPC+A GDP PV++W KVG+  + +     + SL  R 
Sbjct: 400  APPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRP 459

Query: 478  LSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGY 537
            L+KE HG WEC A+N V  +  ST++ V+GTSPH   +V V      ANVSWEPG+DGGY
Sbjct: 460  LTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGY 519

Query: 538  EQTFSVW----MKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAF 593
             Q FSVW     KR     HDW+SL VP G + LLV  L+P T YQFSVLAQNKLG+  F
Sbjct: 520  LQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPF 579

Query: 594  SEVVTVNTLAFPITTPEPLVLVT-------PPRCLIANRTQQGVLLSWLPPANHSFPIDR 646
            SE+V       P T   P +  T       PPR L+A RT +GVLL W PP      +D 
Sbjct: 580  SEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDG 639

Query: 647  YIMEFRV-AERWELLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSS 705
            Y++E R  ++ WE+LD  + GTE E     L +D  YEFR++A     +S+PSN A VS+
Sbjct: 640  YVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVST 699

Query: 706  T--DIFPQPDLTEDGLARPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKK--- 760
            +  +++P        L +PVLAG+V  +CFL  A+L S LA C +N++R  + +RK+   
Sbjct: 700  SGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQ 759

Query: 761  DPPLSITHCRKSLESPLSSGKVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLY 820
            DPPL  +   KS  +P + G  SP+S+  L+        QG P              SL 
Sbjct: 760  DPPLIFSPTGKS-AAPSALGSGSPDSVAKLKL-------QGSPVP------------SLR 799

Query: 821  KKTKRAISSKKYSVAKAEAEAEATTPIELISRGPDGRFVMDPAEMEPSLKSRRIEGFPFA 880
            +       +   S       +    P+E I RGPDGRFVM P    P  +S R +  P  
Sbjct: 800  QSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRT 859

Query: 881  EETDMYPEFRQSDEENEDPLVPTSVAALKSQLTPLSSSQESYLPPPAYSPRFQPRGLEGP 940
                +   F  S         P  +      ++P++       PPPA      P  L GP
Sbjct: 860  PAQRLARSFDCSSSSPSGAPQPLCI----EDISPVA-------PPPA----APPSPLPGP 904

Query: 941  GGLEGRLQATGQARPPAPRPFHHGQYYGYLSSSSPGEVEPPPFYVPEVGSPLSSVMSSPP 1000
            G L   L        P  R  +    +  L   SP     PP Y+     P SS + SP 
Sbjct: 905  GPLLQYLSL------PFFREMNVDGDWPPLEEPSPA---APPDYMDTRRCPTSSFLRSPE 955

Query: 1001 LPTEGP 1006
             P   P
Sbjct: 956  TPPVSP 961



 Score = 35.4 bits (80), Expect = 0.37
 Identities = 81/314 (25%), Positives = 105/314 (33%), Gaps = 56/314 (17%)

Query: 970  LSSSSPGEVEPPPFYVPEVGSPLSSVMSSPPLPTEGPFGHPTIPEENGENASNSTLPLTQ 1029
            L S SP  V         V S   S++   P  T  P  HP  P   G       LPL  
Sbjct: 777  LGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSP--HPDPPSSRGP------LPLEP 828

Query: 1030 TPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLPPCDVPESLQPKAGLPRGLPPTSLQVPA 1089
               G     P GR  F  G    P +  P +    +  E   P   L R    +S   P+
Sbjct: 829  ICRG-----PDGR--FVMG----PTVAAPQERSGREQAEPRTPAQRLARSFDCSSSS-PS 876

Query: 1090 AYPGILSLEAPKGWAGKSPGRGPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGMGIPVLPY 1149
              P  L +E        SP   P  APP+      P+   +S    R  +     P L  
Sbjct: 877  GAPQPLCIE------DISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEE 930

Query: 1150 PEPAEPGAHGGPSTFGLDTR------WYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSP 1203
            P PA P  +       +DTR      +      P  SPR+      SL   V+     + 
Sbjct: 931  PSPAAPPDY-------MDTRRCPTSSFLRSPETPPVSPRE------SLPGAVVGAGATAE 977

Query: 1204 LTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSTGSPSQSSR 1263
               + L+  T       R R  PGLL  A    +T Q     S  R S      PS +  
Sbjct: 978  PPYTALADWT------LRERLLPGLLPAAPRGSLTSQ-----SSGRGSASFLRPPSTAPS 1026

Query: 1264 SGSPSYRPAMGFTT 1277
            +G     PA G T+
Sbjct: 1027 AGGSYLSPAPGDTS 1040



 Score = 33.1 bits (74), Expect = 1.9
 Identities = 77/307 (25%), Positives = 107/307 (34%), Gaps = 50/307 (16%)

Query: 1061 LPPCDVPESLQPKAGL-----PRGL-----PPTSLQVPAAYPGILSLEAPKGWAGKSPGR 1110
            LPP ++P  L P  GL     PRG+     PP    VP    G + LE  +G  G     
Sbjct: 599  LPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPE--LVPKRLDGYV-LEGRQGSQG----- 650

Query: 1111 GPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGMGIPVLPYPEPAEPGAHGGPSTFGLD--- 1167
              V  P  A  +   + P    G ++       +        ++P      ST GL+   
Sbjct: 651  WEVLDPAVAGTETELLVP----GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYP 706

Query: 1168 TRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSPLTQSPLSSRTGSPELAARARPRPG 1227
            +R   P   P+P           L   VL    +S L    L+ R  +     R R  P 
Sbjct: 707  SRTQLPGLLPQPVLAGVVGGVCFLGVAVL----VSILAGCLLNRRRAARRRRKRLRQDPP 762

Query: 1228 LL-----QQAEMSEITLQPPAAVSFSRKSTPSTGSPSQSSRSGSPSYRPAMGFTTLATGY 1282
            L+     + A  S +    P +V+  +       S  QS   G P+  P        + +
Sbjct: 763  LIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTP--------SPH 814

Query: 1283 PSPPP--GPAPAGP----GDSLDVFGQTPS--PRRTGEELLRPETPPPTLPTSGKLQRDR 1334
            P PP   GP P  P     D   V G T +    R+G E   P TP   L  S       
Sbjct: 815  PDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSS 874

Query: 1335 PAPATSP 1341
            P+ A  P
Sbjct: 875  PSGAPQP 881


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  165 bits (417), Expect = 3e-40
 Identities = 138/474 (29%), Positives = 204/474 (43%), Gaps = 49/474 (10%)

Query: 31   EFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRA 90
            E+V A   + + L C+      G PPP +  W K G  I   I               R 
Sbjct: 4087 EYVIA-VDKPITLSCEA----DGLPPPDIT-WHKDGRAIVESI---------------RQ 4125

Query: 91   SLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIE 150
             +    SL++  V+  D G Y C    +     T        LT++ PP    T   Y  
Sbjct: 4126 RVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTS-----TKLTVHVPPRIRSTEGHYT- 4179

Query: 151  AKEGGSITMTCTAFGNPKPIVTWLKEGTLLG-ASGKYQVSD-GSLTVTSVSREDRGAYTC 208
              E     + C A G P P + W K+  LL    GKY     G L + +V  ED G YTC
Sbjct: 4180 VNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTC 4239

Query: 209  RAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYP-GNLTYTWYWQD 267
             A +  GE  HT  L V   P     P ++++N  +   L+C+A   P   LT+T     
Sbjct: 4240 VANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWT----- 4294

Query: 268  ENVYFQNDLKLRVRILIDG--TLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPA 325
                F N++       ++G   L+I RV  EDSG Y C   NS+G   +       + P 
Sbjct: 4295 ----FNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPV 4350

Query: 326  RVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIE 385
               + P     P+G +  + C V  +P  T+ +WN+ G  +++   +    + +GS+ I 
Sbjct: 4351 FKGDYPSNWIEPLGGNAILNCEVKGDPTPTI-QWNRKGVDIEISHRI--RQLGNGSLAIY 4407

Query: 386  EATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAA 445
                E  G YTCV  N  G + +S    L L+ PP  T+ P  E    AG ++++ C A 
Sbjct: 4408 GTVNEDAGDYTCVATNEAGVVERSMS--LTLQSPPIITLEPV-ETVINAGGKIILNCQAT 4464

Query: 446  GDPFPVITWRKVGKPSR--SKHSALPSGSLQFRALSKEDHGEWECVATNVVTSI 497
            G+P P ITW + G       + + L + SL      KED  E+ECVA N++ S+
Sbjct: 4465 GEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSV 4518



 Score =  151 bits (381), Expect = 5e-36
 Identities = 138/484 (28%), Positives = 207/484 (42%), Gaps = 40/484 (8%)

Query: 29   EPEFVTARAGE-SVVLRCDVIHP--VTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPE 85
            EP  +  +  E  V+L   ++ P   TG P P++  W K G+             +V+  
Sbjct: 3986 EPPVIQPQPSELHVILNNPILLPCEATGTPSPFIT-WQKEGI-------------NVNTS 4031

Query: 86   YAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETP 145
                A L     L++ +   ED G Y C       Q         + L +  PP  +   
Sbjct: 4032 GRNHAVL-PSGGLQISRAVREDAGTYMCVA-----QNPAGTALGKIKLNVQVPPVISPHL 4085

Query: 146  PQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQV-SDGSLTVTSVSREDRG 204
             +Y+ A +   IT++C A G P P +TW K+G  +  S + +V S GSL +  V   D G
Sbjct: 4086 KEYVIAVDK-PITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAG 4144

Query: 205  AYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWY 264
             YTC A ++ G +  +T L V  PP I S   + TVN +  A+L C A+  P   T    
Sbjct: 4145 HYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIP---TPAIN 4201

Query: 265  WQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
            W+ +NV   N L  +      G LI+  V  EDSG YTCV +N+ G   + +  LTV   
Sbjct: 4202 WKKDNVLLAN-LLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGED-THTVSLTVHVL 4259

Query: 325  ARVLNMPPVIYVPVGIHGYIRCPVDAEP-PATVVKWNKDGRPLQVEKNLGWTLMEDGSIR 383
                 +P  + +  G    + C     P P     +N +  P   +   G        + 
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNG-----HSELV 4314

Query: 384  IEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCA 443
            IE  ++E  GTY C   N++G +   A   + +K+PP F       + +  G   ++ C 
Sbjct: 4315 IERVSKEDSGTYVCTAENSVGFV--KAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCE 4372

Query: 444  AAGDPFPVITWRKVGKPSRSKH--SALPSGSLQFRALSKEDHGEWECVATNVVTSITAST 501
              GDP P I W + G      H    L +GSL       ED G++ CVATN    +  S 
Sbjct: 4373 VKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSM 4432

Query: 502  HLTV 505
             LT+
Sbjct: 4433 SLTL 4436



 Score =  145 bits (365), Expect = 3e-34
 Identities = 126/457 (27%), Positives = 194/457 (42%), Gaps = 42/457 (9%)

Query: 91   SLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIE 150
            ++    SL +E+V+ +D G Y C    +        N     + ++  PT  +   Q + 
Sbjct: 938  TVRSDGSLHIERVQLQDGGEYTCVASNVAGT-----NNKTTSVVVHVLPTI-QHGQQILS 991

Query: 151  AKEGGSITMTCTAFGNPKPIVTWLKEGTLLG-ASGKYQV-SDGSLTVTSVSREDRGAYTC 208
              EG  +T+ C A GNPKP V W K+G L+  +S K+   +DGSL V S   E+ G Y C
Sbjct: 992  TIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVC 1051

Query: 209  RAYSIQGEAVHTTHLLVQGPPFIV--------SPPENITVNISQDALLTCRAEAYPGNLT 260
             A +  G A     L V   P +           P  I+V   ++  L C  ++ P  + 
Sbjct: 1052 TATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI- 1110

Query: 261  YTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLT 320
             TW  + + +   +    R   L  G++ I   +  DSG Y CV +N  G    A   L 
Sbjct: 1111 ITWAKETQLI---SPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQA-VKLN 1166

Query: 321  VQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDG 380
            V  P ++   P  + V VG    I C      P  V+ W+K G  + V+         DG
Sbjct: 1167 VHVPPKIQRGPKHLKVQVGQRVDIPCNAQG-TPLPVITWSKGGSTMLVDGE-HHVSNPDG 1224

Query: 381  SIRIEEATEEALGTYTCVPYNTLG------TMGQSAPARLVLKDPPYFTVLPGWEYRQEA 434
            ++ I++AT    G YTCV  N  G      T+    P  +   +PPY T        + A
Sbjct: 1225 TLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTF----QERVA 1280

Query: 435  GRELLIPCAAAGDPFPVITWRKVGKPSRSKH---SALPSGS-LQFRALSKEDHGEWECVA 490
             + +  PC A G P P I W   G+    +    S L  G+ L   +++  D+GE+ CVA
Sbjct: 1281 NQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVA 1340

Query: 491  TNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANV 527
             N   +     +L V     H P  ++ +  +T  +V
Sbjct: 1341 VNEAGTTERKYNLKV-----HVPPVIKDKEQVTNVSV 1372



 Score =  142 bits (359), Expect = 2e-33
 Identities = 132/511 (25%), Positives = 215/511 (42%), Gaps = 49/511 (9%)

Query: 27   REEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEY 86
            +++P  ++  AGE V L C+V       PPP ++ W K                 +   +
Sbjct: 1083 QDKPVEISVLAGEEVTLPCEV----KSLPPP-IITWAK--------------ETQLISPF 1123

Query: 87   AGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPP 146
            + R +     S+++ + R+ D G Y C    +            V L ++ PP   +  P
Sbjct: 1124 SPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQA-----VKLNVHVPPKI-QRGP 1177

Query: 147  QYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVS--DGSLTVTSVSREDRG 204
            ++++ + G  + + C A G P P++TW K G+ +   G++ VS  DG+L++   +  D G
Sbjct: 1178 KHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAG 1237

Query: 205  AYTCRAYSIQGEAVHTTHLLVQGPPFI--VSPPENITVN---ISQDALLTCRAEAYPGNL 259
             YTC A +I G       L VQ PP +  + PP N T      +Q     C A+  P   
Sbjct: 1238 IYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTP-KP 1296

Query: 260  TYTWYWQDENVYFQNDLKLRVRILIDGT-LIIFRVKPEDSGKYTCVPSNSLGRSPSASAY 318
            T  W      +      +  + IL DGT L+I  V P D+G+Y CV  N  G +      
Sbjct: 1297 TIKWLHNGREL---TGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAG-TTERKYN 1352

Query: 319  LTVQYPARVLNMPPVIYVPVGIHGY--IRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTL 376
            L V  P  + +   V  V V ++    + C V+   P+ ++ W KD   +QV ++     
Sbjct: 1353 LKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEG-TPSPIIMWYKDN--VQVTESSTIQT 1409

Query: 377  MEDGSI-RIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAG 435
            + +G I ++  AT E  G Y+C   N  GT  +     +++      T  P  E      
Sbjct: 1410 VNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPN-EVSVVLN 1468

Query: 436  RELLIPCAAAGDPFPVITWRKVGKP---SRSKHSALPSGS-LQFRALSKEDHGEWECVAT 491
            R++ + C   G PFP I W K GKP          L  G  L  +   + D G ++C  +
Sbjct: 1469 RDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVS 1528

Query: 492  NVVTSITASTHLTVIGTSPHAPGSVRVQVSM 522
            N          LT+        G+V   +S+
Sbjct: 1529 NAAGKQAKDIKLTIYIPPSIKGGNVTTDISV 1559



 Score =  142 bits (359), Expect = 2e-33
 Identities = 135/491 (27%), Positives = 205/491 (41%), Gaps = 66/491 (13%)

Query: 30   PEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGR 89
            P  +    G+S+ L C+V     G PPP  V W K G P+               +  G 
Sbjct: 2299 PTEIIVTRGKSISLECEV----QGIPPP-TVTWMKDGHPLI--------------KAKGV 2339

Query: 90   ASLHDKASLRLEQVRSEDQGWYECKVL----MLDQQYDTFHNGSWVHLTINAPPTF--TE 143
              L +   L+L+ +   D G Y C  +    M D++YD         L+++APP+     
Sbjct: 2340 EILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYD---------LSVHAPPSIIGNH 2390

Query: 144  TPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGS--LTVTSVSRE 201
              P+ I   E  S+++TC A G P P +TW K+G  +  S   ++  G   L +   + E
Sbjct: 2391 RSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTME 2450

Query: 202  DRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPP--ENITVNISQDALLTCRAEAYPGNL 259
            D G YTC   +  GE      L V  PP IV     E++ V   Q   LTC      GN 
Sbjct: 2451 DAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVT---GNP 2507

Query: 260  TYTWYWQDENVYFQNDLKLRVRILIDGT--LIIFRVKPEDSGKYTCVPSNSLGRSPSASA 317
                 W  +    Q D       +I G   L I  V+   +G+YTC+ S+  G   S S 
Sbjct: 2508 VPEITWHKDGQPLQED---EAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHK-SRSF 2563

Query: 318  YLTVQYPARVLNM-----PPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNL 372
             L V     +  +     P  + V +     + C   + PPAT+  W KDG PL+  +N+
Sbjct: 2564 SLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATIT-WFKDGTPLESNRNI 2622

Query: 373  GWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGW---- 428
               L    +++I  A E+  G Y+CV  N  G M +    ++ +  PP       W    
Sbjct: 2623 R-ILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYI--PPIINKGDLWGPGL 2679

Query: 429  ---EYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSK---HSALPSGSLQFRALSKED 482
               E + +    L + C A   P   ++W K G+P +S    + A    +LQ +     D
Sbjct: 2680 SPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISD 2739

Query: 483  HGEWECVATNV 493
             G + CVA+N+
Sbjct: 2740 TGRYTCVASNI 2750



 Score =  142 bits (359), Expect = 2e-33
 Identities = 128/451 (28%), Positives = 185/451 (41%), Gaps = 41/451 (9%)

Query: 89   RASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQY 148
            R S+ +   L ++     D G Y C   M      T      + L ++ PP+    P   
Sbjct: 3759 RYSILENGFLHIQSAHVTDTGRYLC---MATNAAGTDRRR--IDLQVHVPPSIAPGPTN- 3812

Query: 149  IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQ----VSDGSLTVTSVSREDRG 204
            +        T+ C A G PKP + W K G LL           +S GSL + S S +D  
Sbjct: 3813 MTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTA 3872

Query: 205  AYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWY 264
             Y C   +  G+   T  L VQ PP I   P +  V     A++TC A   P    + W 
Sbjct: 3873 TYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIH-WT 3931

Query: 265  WQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
                 +  + D     RIL  G + I   +   +G+YTCV  N+ G   SA  ++T+   
Sbjct: 3932 KNGIRLLPRGD---GYRILSSGAIEILATQLNHAGRYTCVARNAAG---SAHRHVTLH-- 3983

Query: 325  ARVLNMPPVIY-VPVGIHGYIRCPV-----DAEPPATVVKWNKDGRPLQVEKNLGWTLME 378
               ++ PPVI   P  +H  +  P+         P+  + W K+G  +         ++ 
Sbjct: 3984 ---VHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNT-SGRNHAVLP 4039

Query: 379  DGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGW-EYRQEAGRE 437
             G ++I  A  E  GTY CV  N  GT       +L ++ PP   + P   EY     + 
Sbjct: 4040 SGGLQISRAVREDAGTYMCVAQNPAGT--ALGKIKLNVQVPP--VISPHLKEYVIAVDKP 4095

Query: 438  LLIPCAAAGDPFPVITWRKVGKP--SRSKHSALPSGSLQFRALSKEDHGEWECVATNVVT 495
            + + C A G P P ITW K G+      +   L SGSLQ   +   D G + C+A NV  
Sbjct: 4096 ITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAG 4155

Query: 496  SITASTHLTVIGTSPHAPGSVRVQVSMTTAN 526
            S + ST LTV     H P  +R      T N
Sbjct: 4156 SSSTSTKLTV-----HVPPRIRSTEGHYTVN 4181



 Score =  136 bits (342), Expect = 2e-31
 Identities = 151/599 (25%), Positives = 234/599 (39%), Gaps = 49/599 (8%)

Query: 28   EEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYA 87
            E    V  R G SV L C+     +   PP V+ W+K G  I           HV+    
Sbjct: 3064 ESLSVVNVREGTSVSLECE-----SNAVPPPVITWYKNGRMIT-------ESTHVE---- 3107

Query: 88   GRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQ 147
                L D   L +++    D G Y C+ + +  + D        HL +  PP+      +
Sbjct: 3108 ---ILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNF-----HLNVYVPPSIEGPERE 3159

Query: 148  YIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQV---SDGS-LTVTSVSREDR 203
             I       +T+TC A G P P + WLK    +  S   +V   S GS L +      D 
Sbjct: 3160 VIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDS 3219

Query: 204  GAYTCRAYSIQGEAVHTTHLLVQGPPFIVSP--PENITVNISQDALLTCRAEAYPGNLTY 261
            G YTC A +++G+A     L +Q PP +     P +++V + ++  L C A   P  L  
Sbjct: 3220 GNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLI- 3278

Query: 262  TWYWQDENVYFQNDLKLRVRILIDG-TLIIFRVKPEDSGKYTCVPSNSLG---RSPSASA 317
               W  +     +    R+R+  +G TL I+     D+GKYTCV +N  G   R  + + 
Sbjct: 3279 --QWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNV 3336

Query: 318  YLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLM 377
            Y+T            ++ + V     I C     PP   + W K+G PL +  ++   L+
Sbjct: 3337 YVTPTIRGNKDEAEKLMTL-VDTSINIECRATGTPPPQ-INWLKNGLPLPLSSHI--RLL 3392

Query: 378  EDGS-IRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGR 436
              G  IRI  A    +  YTCV  N  G   +    + V   P     +   E     G 
Sbjct: 3393 AAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQ-VFAPPNMDNSMGTEEITVLKGS 3451

Query: 437  ELLIPCAAAGDPFPVITWRKVGKP-SRSKHSALPSGS--LQFRALSKEDHGEWECVATNV 493
               + C   G P P + W + G+P     H  + +    LQ      ED G++ C+A+N 
Sbjct: 3452 STSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNE 3511

Query: 494  VTSITASTHLTVIGTSPHAPGS-VRVQVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFGP 552
               ++    L V+   PH  GS    ++S+   N         G       WMK  +  P
Sbjct: 3512 AGEVSKHFILKVL-EPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLP 3570

Query: 553  HDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEP 611
                 +    G   L + T + E   +++ LA +  G      +V V+       T EP
Sbjct: 3571 QT-DQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEP 3628



 Score =  135 bits (341), Expect = 2e-31
 Identities = 140/502 (27%), Positives = 203/502 (40%), Gaps = 71/502 (14%)

Query: 25   GLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDP 84
            G    PE ++     SV L C+     +G P P +  WFK G P+ +             
Sbjct: 2388 GNHRSPENISVVEKNSVSLTCEA----SGIPLPSIT-WFKDGWPVSLSNSVRI------- 2435

Query: 85   EYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFT-E 143
                   L     LRL Q   ED G Y C V     +           L++  PP    E
Sbjct: 2436 -------LSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFG-----LSVLVPPHIVGE 2483

Query: 144  TPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGS--LTVTSVSRE 201
               + ++ KE  S+T+TC   GNP P +TW K+G  L     + +  G   L +T+V   
Sbjct: 2484 NTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVP 2543

Query: 202  DRGAYTCRAYSIQGEAVHTTHLLVQGPPFIV-----SPPENITVNISQDALLTCRAEAYP 256
              G YTC A S  G    +  L V   P I        PE++TV ++    L C A +YP
Sbjct: 2544 HTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYP 2603

Query: 257  GNLTYTWYWQDENVYFQNDLKLRVRILIDG-TLIIFRVKPEDSGKYTCVPSNSLGRSPSA 315
               T TW+     +    +    +RIL  G TL I   + +++G+Y+CV +N  G     
Sbjct: 2604 -PATITWFKDGTPL----ESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGE--MI 2656

Query: 316  SAYLTVQYPARVLN---------MPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPL 366
              Y    Y   ++N          P  + + V     + C   A P A+ + W KDG+PL
Sbjct: 2657 KHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSAS-LSWYKDGQPL 2715

Query: 367  QVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLP 426
            + + ++        +++I+EA     G YTCV  N  G         + ++ PP F  L 
Sbjct: 2716 KSDDHVN-IAANGHTLQIKEAQISDTGRYTCVASNIAGE--DELDFDVNIQVPPSFQKL- 2771

Query: 427  GWEY-------RQEAGRELLIP------CAAAGDPFPVITWRKVGKP--SRSKHSALPSG 471
             WE        R    ++++I       C     P P +TW K G P  S  K   LP G
Sbjct: 2772 -WEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGG 2830

Query: 472  S-LQFRALSKEDHGEWECVATN 492
              LQ      ED G + CVA N
Sbjct: 2831 RVLQIPRAKVEDAGRYTCVAVN 2852



 Score =  135 bits (339), Expect = 3e-31
 Identities = 146/592 (24%), Positives = 232/592 (39%), Gaps = 51/592 (8%)

Query: 28   EEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYA 87
            EE E ++      + L C      +G P P +  W K G P+P              +  
Sbjct: 3533 EEHEEISVIVNNPLELTCIA----SGIPAPKMT-WMKDGRPLP--------------QTD 3573

Query: 88   GRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETP-P 146
               +L     LR+   + ED G Y C         D  +      + ++ PP    T  P
Sbjct: 3574 QVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYL-----VRVHVPPNIAGTDEP 3628

Query: 147  QYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGS--LTVTSVSREDRG 204
            + I       +T+ C +   P P++TWL+ G  L A+ + ++  G   L + +    D  
Sbjct: 3629 RDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTA 3688

Query: 205  AYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWY 264
             YTC A +I G+      L V  PP I   P+++ + +++  +L C AE  P   T    
Sbjct: 3689 NYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVP---TPRIT 3745

Query: 265  WQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
            W+ +      +   R  IL +G L I      D+G+Y C+ +N+ G +      L V  P
Sbjct: 3746 WRKDGAVLAGN-HARYSILENGFLHIQSAHVTDTGRYLCMATNAAG-TDRRRIDLQVHVP 3803

Query: 325  ARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNL-GWTLMEDGSIR 383
              +   P  + V V +   + C     P  + + W K+G  L V++N   + L+  GS+ 
Sbjct: 3804 PSIAPGPTNMTVIVNVQTTLACEATGIPKPS-INWRKNGHLLNVDQNQNSYRLLSSGSLV 3862

Query: 384  IEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCA 443
            I   + +   TY C   N  G         L ++ PP     P  ++        +I C 
Sbjct: 3863 IISPSVDDTATYECTVTN--GAGDDKRTVDLTVQVPPSIADEP-TDFLVTKHAPAVITCT 3919

Query: 444  AAGDPFPVITWRKVG---KPSRSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITAS 500
            A+G PFP I W K G    P    +  L SG+++  A      G + CVA N   S  A 
Sbjct: 3920 ASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGS--AH 3977

Query: 501  THLTVIGTSPHAPGSVRVQVS---MTTANVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLS 557
             H+T+     H P  ++ Q S   +   N    P    G    F  W K          +
Sbjct: 3978 RHVTL---HVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRN 4034

Query: 558  LPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTP 609
              V P    L +     E A  +  +AQN  GT+     + +N    P+ +P
Sbjct: 4035 HAVLPS-GGLQISRAVREDAGTYMCVAQNPAGTALGK--IKLNVQVPPVISP 4083



 Score =  133 bits (334), Expect = 1e-30
 Identities = 127/500 (25%), Positives = 206/500 (41%), Gaps = 61/500 (12%)

Query: 38   GESVVLRCDVIHPVTGQPPPYVVEWFKFGV---PIPIFIKFGYYPPHVDPEYAGRASLHD 94
            G+  V+ C      +G PPP V +WFK  +   P    I        +DP          
Sbjct: 716  GDITVMECKT----SGIPPPQV-KWFKGDLELRPSTFLI--------IDPLLG------- 755

Query: 95   KASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEG 154
               L++++ +  D G Y C  +      +       + L + +PP F + P   +  + G
Sbjct: 756  --LLKIQETQDLDAGDYTCVAIN-----EAGRATGKITLDVGSPPVFIQEPAD-VSMEIG 807

Query: 155  GSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSD------GSLTVTSVSREDRGAYTC 208
             ++T+ C   G P+P + W +   +   S  + VS       G+L + ++   D+G Y C
Sbjct: 808  SNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYIC 867

Query: 209  RAYSIQGEAVHTTHLLVQG--PPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQ 266
             A +  G+    T + V G   P I   P    V   Q   L C   A  GN      W 
Sbjct: 868  EAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLA--GNPIPERRWI 925

Query: 267  DENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPAR 326
              +     +  + VR   DG+L I RV+ +D G+YTCV SN  G +   ++ +    P  
Sbjct: 926  KNSAMLLQNPYITVRS--DGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPT- 982

Query: 327  VLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEE 386
            + +   ++    GI   + C     P  +V+ W+K G  +    +  ++   DGS+ +  
Sbjct: 983  IQHGQQILSTIEGIPVTLPCKASGNPKPSVI-WSKKGELIST-SSAKFSAGADGSLYVVS 1040

Query: 387  ATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGW------EYRQEAGRELLI 440
               E  G Y C   NT G   +     + ++ P  F    G       E    AG E+ +
Sbjct: 1041 PGGEESGEYVCTATNTAGYAKRKVQLTVYVR-PRVFGDQRGLSQDKPVEISVLAGEEVTL 1099

Query: 441  PCAAAGDPFPVITWRK---VGKPSRSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSI 497
            PC     P P+ITW K   +  P   +H+ LPSGS++       D G + CVATN+  ++
Sbjct: 1100 PCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNV 1159

Query: 498  TASTHLTVIGTSPHAPGSVR 517
            T +  L V     H P  ++
Sbjct: 1160 TQAVKLNV-----HVPPKIQ 1174



 Score =  122 bits (305), Expect = 3e-27
 Identities = 120/433 (27%), Positives = 179/433 (41%), Gaps = 39/433 (9%)

Query: 92  LHDKASLRLE--QVRSEDQGWYECKVLML--DQQYDTFHNGSWVHLTINAPPTFTETPPQ 147
           L + AS+ L+  +V   D+G+YEC  +      +  TF + S     I  P   T TP  
Sbjct: 476 LKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTP-- 533

Query: 148 YIEAKEGGSITMTCTAFGNPKPIVTWL---KEGTLLGASGKYQVSDGSLTVTSVSREDRG 204
                 G    +TC         +TW    ++  L   +    +++ SL + SV   D G
Sbjct: 534 ------GERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAG 587

Query: 205 AYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWY 264
            Y C   S  G +  +  L VQ PP +   P+N +     +  + C A  YP      W 
Sbjct: 588 EYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYP-KPKIAWT 646

Query: 265 WQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
             D  +   +    R R+  DGTL I    P+D+G Y C+ SNS G     S    ++ P
Sbjct: 647 VNDMFIVGSH----RYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAP 702

Query: 325 ARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMED---GS 381
            +++ +   + V +G    + C     PP   VKW K      +E      L+ D   G 
Sbjct: 703 -KLMVVQSELLVALGDITVMECKTSGIPPPQ-VKWFKG----DLELRPSTFLIIDPLLGL 756

Query: 382 IRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIP 441
           ++I+E  +   G YTCV  N  G    +    L +  PP F   P  +   E G  + +P
Sbjct: 757 LKIQETQDLDAGDYTCVAINEAGR--ATGKITLDVGSPPVFIQEPA-DVSMEIGSNVTLP 813

Query: 442 CAAAGDPFPVITWRKV------GKP-SRSKHSALPSGSLQFRALSKEDHGEWECVATNVV 494
           C   G P P I WR++       +P S S  S L +G+L    L   D G + C A N  
Sbjct: 814 CYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQF 873

Query: 495 TSITASTHLTVIG 507
             I + T +TV G
Sbjct: 874 GKIQSETTVTVTG 886



 Score =  120 bits (302), Expect = 7e-27
 Identities = 128/496 (25%), Positives = 206/496 (41%), Gaps = 64/496 (12%)

Query: 30  PEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGR 89
           P  VT   GE  VL C +I  V      Y + W +    + +           +P    R
Sbjct: 526 PNNVTVTPGERAVLTCLIISAVD-----YNLTWQRNDRDVRL----------AEP---AR 567

Query: 90  ASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYI 149
                  SL L+ V+  D G Y C V       +   + + V LT+  PP  T  P    
Sbjct: 568 IRTLANLSLELKSVKFNDAGEYHCMV-----SSEGGSSAASVFLTVQEPPKVTVMPKN-- 620

Query: 150 EAKEGGS-ITMTCTAFGNPKPIVTWLKEGTLLGASGKYQV-SDGSLTVTSVSREDRGAYT 207
           ++  GGS +++ C+A G PKP + W      +  S +Y++ SDG+L + + + +D G Y 
Sbjct: 621 QSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYG 680

Query: 208 CRAYSIQG-EAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQ 266
           C A +  G +  ++T   ++ P  +V   E + V +    ++ C+    P          
Sbjct: 681 CLASNSAGTDKQNSTLRYIEAPKLMVVQSE-LLVALGDITVMECKTSGIP---------P 730

Query: 267 DENVYFQNDLKLR--VRILID---GTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTV 321
            +  +F+ DL+LR    ++ID   G L I   +  D+G YTCV  N  GR+ +    L V
Sbjct: 731 PQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRA-TGKITLDV 789

Query: 322 QYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNK------DGRPLQVEKNLGWT 375
             P   +  P  + + +G +  + C V   P  T +KW +        RP  V      +
Sbjct: 790 GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPT-IKWRRLDNMPIFSRPFSVS---SIS 845

Query: 376 LMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAG 435
            +  G++ I        GTY C   N  G +       +     P   + P      E G
Sbjct: 846 QLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIE-G 904

Query: 436 RELLIPCA-AAGDPFPVITWRK-----VGKPSRSKHSALPSGSLQFRALSKEDHGEWECV 489
           ++L +PC   AG+P P   W K     +  P  +  S    GSL    +  +D GE+ CV
Sbjct: 905 QQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRS---DGSLHIERVQLQDGGEYTCV 961

Query: 490 ATNVVTSITASTHLTV 505
           A+NV  +   +T + V
Sbjct: 962 ASNVAGTNNKTTSVVV 977



 Score =  116 bits (291), Expect = 1e-25
 Identities = 111/429 (25%), Positives = 181/429 (42%), Gaps = 32/429 (7%)

Query: 100  LEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITM 159
            +E  +  D G Y+C  +      + F++     L ++  P+ + +    +       + +
Sbjct: 1978 IESAQISDAGIYKCVAINSAGATELFYS-----LQVHVAPSISGSN-NMVAVVVNNPVRL 2031

Query: 160  TCTAFGNPKPIVTWLKEGTLLGA-SGKYQVSDGS--LTVTSVSREDRGAYTCRAYSIQGE 216
             C A G P P +TWLK+G+ + + S   QV  G   L +TS    D G YTC A +  GE
Sbjct: 2032 ECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGE 2091

Query: 217  AVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDL 276
                  L V  PP I+   +N++V ISQ   L C+++A P   T TW      +  +  L
Sbjct: 2092 KQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPP-TLTWLKDGHPLLKKPGL 2150

Query: 277  KLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYV 336
             +         L I   + +D+G+YTC  +N  G++   +  + +  P  +     +  +
Sbjct: 2151 SISEN---RSVLKIEDAQVQDTGRYTCEATNVAGKT-EKNYNVNIWVPPNIGGSDELTQL 2206

Query: 337  PVGIHG---YIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDG---SIRIEEATEE 390
             V I G    + C     PP  ++ W K G P+  +      ++  G    I I E ++ 
Sbjct: 2207 TV-IEGNLISLLCESSGIPPPNLI-WKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDA 2264

Query: 391  ALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFP 450
            AL  Y+CV  N  GT  +    ++ ++     +     E     G+ + + C   G P P
Sbjct: 2265 AL--YSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPP 2322

Query: 451  VITWRKVGKP--SRSKHSALPSGS-LQFRALSKEDHGEWECVATNVVTSITASTHLTVIG 507
             +TW K G P         L  G  LQ + +   D G + CVA NV         L+V  
Sbjct: 2323 TVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSV-- 2380

Query: 508  TSPHAPGSV 516
               HAP S+
Sbjct: 2381 ---HAPPSI 2386



 Score =  116 bits (290), Expect = 2e-25
 Identities = 134/487 (27%), Positives = 195/487 (40%), Gaps = 53/487 (10%)

Query: 25   GLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDP 84
            G  +E   +T   G  + L C+     +G PPP ++ W K G P+               
Sbjct: 2198 GGSDELTQLTVIEGNLISLLCES----SGIPPPNLI-WKKKGSPVLT------------- 2239

Query: 85   EYAGRAS-LHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTE 143
            +  GR   L     L++      D   Y C    +       +N     L +   PT T 
Sbjct: 2240 DSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYN-----LQVYIRPTITN 2294

Query: 144  TP--PQYIEAKEGGSITMTCTAFGNPKPIVTWLKEG-TLLGASGKYQVSDGS-LTVTSVS 199
            +   P  I    G SI++ C   G P P VTW+K+G  L+ A G   + +G  L + ++ 
Sbjct: 2295 SGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIH 2354

Query: 200  REDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVS---PPENITVNISQDALLTCRAEAYP 256
              D G Y C A ++ G       L V  PP I+     PENI+V       LTC A   P
Sbjct: 2355 VSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIP 2414

Query: 257  GNLTYTWYWQDENVYFQNDLKLRVRILIDGTLI-IFRVKPEDSGKYTCVPSNSLGRSPSA 315
               + TW+     V   N     VRIL  G ++ + +   ED+G+YTCV  N+ G     
Sbjct: 2415 -LPSITWFKDGWPVSLSNS----VRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKI 2469

Query: 316  SAYLTVQYPARVL--NMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLG 373
               L+V  P  ++  N    + V       + C V    P   + W+KDG+PLQ E    
Sbjct: 2470 FG-LSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGN-PVPEITWHKDGQPLQ-EDEAH 2526

Query: 374  WTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQE 433
              +     ++I        G YTC+  +  G   +S     V   P    V  G +   E
Sbjct: 2527 HIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLN-VFVSPTIAGV--GSDGNPE 2583

Query: 434  AGRELL-----IPCAAAGDPFPVITWRKVGKPSRSKHS--ALPSG-SLQFRALSKEDHGE 485
                +L     + C A   P   ITW K G P  S  +   LP G +LQ     +++ G 
Sbjct: 2584 DVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGR 2643

Query: 486  WECVATN 492
            + CVATN
Sbjct: 2644 YSCVATN 2650



 Score =  115 bits (287), Expect = 4e-25
 Identities = 131/501 (26%), Positives = 203/501 (40%), Gaps = 59/501 (11%)

Query: 26   LREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPE 85
            ++  P+ +  + G+ V + C+      G P P V+ W K G  +            VD E
Sbjct: 1173 IQRGPKHLKVQVGQRVDIPCNA----QGTPLP-VITWSKGGSTML-----------VDGE 1216

Query: 86   YAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETP 145
            +    S  D  +L ++Q    D G Y C    +    +T      + L +  PPT  +  
Sbjct: 1217 H--HVSNPD-GTLSIDQATPSDAGIYTCVATNIAGTDETE-----ITLHVQEPPTVEDLE 1268

Query: 146  PQYI----EAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGAS--GKYQVSDGSLTV-TSV 198
            P Y     E      I   C A G PKP + WL  G  L     G   + DG+L V  SV
Sbjct: 1269 PPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASV 1328

Query: 199  SREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPE--NITVNISQDALLTCRAEAYP 256
            +  D G Y C A +  G      +L V  PP I    +  N++V ++Q   L C  E  P
Sbjct: 1329 TPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTP 1388

Query: 257  GNLTYTWYWQDENVYFQNDLKLRVRILIDGTLI-IFRVKPEDSGKYTCVPSNSLGRSPSA 315
              +     W  +NV  Q      ++ + +G ++ +FR  PED+G+Y+C   N  G S   
Sbjct: 1389 SPIIM---WYKDNV--QVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKY 1443

Query: 316  SAYLTVQYPARVL--NMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQV-EKNL 372
               + V  P  ++  N P  + V +     + C V   P   +  W KDG+PL + + N+
Sbjct: 1444 FN-IDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDI-HWFKDGKPLFLGDPNV 1501

Query: 373  GWTLMEDGSI-RIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYR 431
               L++ G +  ++ A     G Y C   N  G   Q+   +L +  PP    + G    
Sbjct: 1502 --ELLDRGQVLHLKNARRNDKGRYQCTVSNAAGK--QAKDIKLTIYIPPS---IKGGNVT 1554

Query: 432  QEAG----RELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSK---EDHG 484
             +        + + C   G P P ITW K G+P  S   AL     Q+  + +    D  
Sbjct: 1555 TDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSA 1614

Query: 485  EWECVATNVVTSITASTHLTV 505
             + C   NV  +   S H+ V
Sbjct: 1615 TYTCHVANVAGTAEKSFHVDV 1635



 Score =  111 bits (277), Expect = 5e-24
 Identities = 124/482 (25%), Positives = 197/482 (40%), Gaps = 54/482 (11%)

Query: 34   TARAGES--VVLRCDV-IHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRA 90
            T R GE+  V++   + ++  T   PP  + W+K G P+    K    P        GR 
Sbjct: 2780 TGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILP-------GGRV 2832

Query: 91   SLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTF---TETPPQ 147
                   L++ + + ED G Y C V + +   D+        + +  PP         P+
Sbjct: 2833 -------LQIPRAKVEDAGRYTC-VAVNEAGEDSLQ----YDVRVLVPPIIKGANSDLPE 2880

Query: 148  YIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQ-VSDGS-LTVTSVSREDRGA 205
             +      S  + C + G+P P  +W K+G  L     ++ +S+G  L + +    D G 
Sbjct: 2881 EVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGR 2940

Query: 206  YTCRAYSIQGEAVHTTHLLVQGPPFIVSPP-ENITVNISQDALLTCRAEAYPGNLTYTWY 264
            Y C A +  G A    +L V  PP ++ P  EN+TV ++    LTC    +P     +W 
Sbjct: 2941 YVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPP-DLSWL 2999

Query: 265  WQDENVYFQNDLKLRVRILI---DGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTV 321
              ++ +      KL    LI     TL I R K  D G+YTC+  N  G S    + LTV
Sbjct: 3000 KNEQPI------KLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFS-LTV 3052

Query: 322  QYPARVLNMP----PVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLM 377
              P  + +       V+ V  G    + C  +A PP  V+ W K+GR   + ++    ++
Sbjct: 3053 YVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPP-PVITWYKNGR--MITESTHVEIL 3109

Query: 378  EDGS-IRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGR 436
             DG  + I++A     G Y C   N  G   ++    + +  PP           +    
Sbjct: 3110 ADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYV--PPSIEGPEREVIVETISN 3167

Query: 437  ELLIPCAAAGDPFPVITWRKVGKPSRSKHS----ALPSGS-LQFRALSKEDHGEWECVAT 491
             + + C A G P P I W K  K   +  S     L  GS LQ       D G + C+A+
Sbjct: 3168 PVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIAS 3227

Query: 492  NV 493
            N+
Sbjct: 3228 NM 3229



 Score =  110 bits (275), Expect = 9e-24
 Identities = 112/422 (26%), Positives = 178/422 (42%), Gaps = 32/422 (7%)

Query: 98   LRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAK-EGGS 156
            L++ +   ED G Y C  +  +   +T  +   + L ++ PP+  +      E       
Sbjct: 1883 LQIAKTLLEDAGRYTC--VATNAAGETQQH---IQLHVHEPPSLEDAGKMLNETVLVSNP 1937

Query: 157  ITMTCTAFGNPKPIVTWLKEGTLL-GASGKYQVSDGSLT-VTSVSREDRGAYTCRAYSIQ 214
            + + C A GNP P++TW K+  LL G++    ++ G +  + S    D G Y C A +  
Sbjct: 1938 VQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSA 1997

Query: 215  GEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENV-YFQ 273
            G       L V   P I      + V ++    L C A   P   + TW      V  F 
Sbjct: 1998 GATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAP-SLTWLKDGSPVSSFS 2056

Query: 274  NDLKLRVRILIDGTLI-IFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPP 332
            N L    ++L  G ++ +   +  D+G+YTCV  N+ G        L V  P  ++    
Sbjct: 2057 NGL----QVLSGGRILALTSAQISDTGRYTCVAVNAAGEK-QRDIDLRVYVPPNIMGEEQ 2111

Query: 333  VIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSI-RIEEATEEA 391
             + V +     + C  DA PP T+  W KDG PL   K  G ++ E+ S+ +IE+A  + 
Sbjct: 2112 NVSVLISQAVELLCQSDAIPPPTLT-WLKDGHPLL--KKPGLSISENRSVLKIEDAQVQD 2168

Query: 392  LGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEA---GRELLIPCAAAGDP 448
             G YTC   N  G   ++    + +  PP   +    E  Q     G  + + C ++G P
Sbjct: 2169 TGRYTCEATNVAGKTEKNYNVNIWV--PP--NIGGSDELTQLTVIEGNLISLLCESSGIP 2224

Query: 449  FPVITWRKVGKP----SRSKHSALPSG-SLQFRALSKEDHGEWECVATNVVTSITASTHL 503
             P + W+K G P    S  +   L  G  LQ     K D   + CVA+NV  +     +L
Sbjct: 2225 PPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNL 2284

Query: 504  TV 505
             V
Sbjct: 2285 QV 2286



 Score =  109 bits (273), Expect = 2e-23
 Identities = 112/475 (23%), Positives = 195/475 (41%), Gaps = 35/475 (7%)

Query: 29   EPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAG 88
            EP + T         R +   P  G P P  ++W   G  +      G  P        G
Sbjct: 1268 EPPYNTTFQERVANQRIEFPCPAKGTPKP-TIKWLHNGRELT-----GREP--------G 1313

Query: 89   RASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQY 148
             + L D   L +  V   D G Y C  +      +  +N     L ++ PP   +     
Sbjct: 1314 ISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYN-----LKVHVPPVIKDKEQVT 1368

Query: 149  IEAKEGGSIT-MTCTAFGNPKPIVTWLKEGTLLGASGKYQ-VSDGS-LTVTSVSREDRGA 205
              +     +T + C   G P PI+ W K+   +  S   Q V++G  L +   + ED G 
Sbjct: 1369 NVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGR 1428

Query: 206  YTCRAYSIQGEAVHTTHLLVQGPPFIVSP--PENITVNISQDALLTCRAEAYPGNLTYTW 263
            Y+C+A +I G +    ++ V  PP I+    P  ++V +++D  L C+ +  P       
Sbjct: 1429 YSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTP--FPDIH 1486

Query: 264  YWQDENVYFQNDLKLRVRILIDGTLIIFR-VKPEDSGKYTCVPSNSLGRSPSASAYLTVQ 322
            +++D    F  D    V +L  G ++  +  +  D G+Y C  SN+ G+  +    LT+ 
Sbjct: 1487 WFKDGKPLFLGDPN--VELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQ-AKDIKLTIY 1543

Query: 323  YPARVLNMPPVIYVPVGIHGYIRCPVDAEP-PATVVKWNKDGRPLQVEKNLGWTLMEDGS 381
             P  +        + V I+  I+   +    P   + W KDG+P+ +  +    + +   
Sbjct: 1544 IPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPI-MSSSQALYIDKGQY 1602

Query: 382  IRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIP 441
            + I  A      TYTC   N  GT  +S    + +       +      +      L + 
Sbjct: 1603 LHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLE 1662

Query: 442  CAAAGDPFPVITWRKVGKPSRSKHSA-LPSGSLQFRALSKE--DHGEWECVATNV 493
            C AAG+P P++TW K G P ++  +  + +G  +   +S +  D G++ CVAT+V
Sbjct: 1663 CKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSV 1717



 Score =  109 bits (272), Expect = 2e-23
 Identities = 110/405 (27%), Positives = 165/405 (40%), Gaps = 35/405 (8%)

Query: 142  TETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQ--VSDGSLTVTSVS 199
            ++  P  I    G  +T+ C     P PI+TW KE  L+         +  GS+ +T   
Sbjct: 1082 SQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETR 1141

Query: 200  REDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNL 259
              D G Y C A +I G       L V  PP I   P+++ V + Q   + C A+  P  +
Sbjct: 1142 TSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPV 1201

Query: 260  TYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYL 319
              TW      +    +  +      DGTL I +  P D+G YTCV +N  G +      L
Sbjct: 1202 -ITWSKGGSTMLVDGEHHVSNP---DGTLSIDQATPSDAGIYTCVATNIAG-TDETEITL 1256

Query: 320  TVQYPARVLNMPP---VIYVPVGIHGYIRCPVDAE-PPATVVKWNKDGRPLQVEKNLGWT 375
             VQ P  V ++ P     +     +  I  P  A+  P   +KW  +GR L   +  G +
Sbjct: 1257 HVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGREL-TGREPGIS 1315

Query: 376  LMEDGSIR-IEEATEEALGTYTCVPYNTLGTMGQSAPARL----VLKDPPYFTVLPGWEY 430
            ++EDG++  I   T    G Y CV  N  GT  +    ++    V+KD    T       
Sbjct: 1316 ILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVT-----NV 1370

Query: 431  RQEAGRELLIPCAAAGDPFPVITWRK--VGKPSRSKHSALPSGSL--QFRALSKEDHGEW 486
                 +   + C   G P P+I W K  V     S    + +G +   FRA + ED G +
Sbjct: 1371 SVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRA-TPEDAGRY 1429

Query: 487  ECVATNVV------TSITASTHLTVIGTSPHAPGSVRVQVSMTTA 525
             C A N+        +I      T+IGT  + P  V V ++   A
Sbjct: 1430 SCKAINIAGTSQKYFNIDVLVPPTIIGT--NFPNEVSVVLNRDVA 1472



 Score =  108 bits (269), Expect = 5e-23
 Identities = 138/564 (24%), Positives = 216/564 (38%), Gaps = 89/564 (15%)

Query: 7    TFIASVIGTRGLAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFG 66
            +F  +V  +  +A  G+ G    PE VT        L C+         PP  + WFK G
Sbjct: 2562 SFSLNVFVSPTIAGVGSDG---NPEDVTVILNSPTSLVCEAY-----SYPPATITWFKDG 2613

Query: 67   VPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFH 126
             P+         P        GR       +L++   + ++ G Y C          T  
Sbjct: 2614 TPLESNRNIRILP-------GGR-------TLQILNAQEDNAGRYSCVA--------TNE 2651

Query: 127  NGSWV---HLTINAPPTFTE-------TPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKE 176
             G  +    + +  PP   +         P+ ++ K   ++T+ C A+  P   ++W K+
Sbjct: 2652 AGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKD 2711

Query: 177  GTLLGASGKYQVSDG--SLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVS- 233
            G  L +     ++    +L +      D G YTC A +I GE      + +Q PP     
Sbjct: 2712 GQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKL 2771

Query: 234  -----------PPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRI 282
                         E   V I+    L C   A P   T TWY +D +    +D   +V I
Sbjct: 2772 WEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPP-TLTWY-KDGHPLTSSD---KVLI 2826

Query: 283  LIDGTLI-IFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVL----------NMP 331
            L  G ++ I R K ED+G+YTCV  N  G         ++QY  RVL          ++P
Sbjct: 2827 LPGGRVLQIPRAKVEDAGRYTCVAVNEAGED-------SLQYDVRVLVPPIIKGANSDLP 2879

Query: 332  PVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEA 391
              + V V     I C + +  PA    W KDG+PL +E +    L     ++I       
Sbjct: 2880 EEVTVLVNKSALIEC-LSSGSPAPRNSWQKDGQPL-LEDDHHKFLSNGRILQILNTQITD 2937

Query: 392  LGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPV 451
            +G Y CV  NT G+  +     L +  PP                 + + C  +G P P 
Sbjct: 2938 IGRYVCVAENTAGSAKKYF--NLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPD 2995

Query: 452  ITWRKVGKPSRSKHSAL--PSG-SLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGT 508
            ++W K  +P +   + L  P G +LQ       D GE+ C+A N          LTV   
Sbjct: 2996 LSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTV--- 3052

Query: 509  SPHAPGSVRVQVSMTTANVSWEPG 532
              + P S++   S + + V+   G
Sbjct: 3053 --YVPPSIKDHDSESLSVVNVREG 3074



 Score =  106 bits (264), Expect = 2e-22
 Identities = 107/384 (27%), Positives = 167/384 (43%), Gaps = 24/384 (6%)

Query: 171 VTWLKEGTLLGASGKYQVSDG-SLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPP 229
           +++++ G  LG     + S   +L +  V+  D G Y C A S  G     T   V  PP
Sbjct: 461 LSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPP 520

Query: 230 FIVSPPENITVNISQDALLTCR-AEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTL 288
            ++  P N+TV   + A+LTC    A   NL  TW   D +V        R+R L + +L
Sbjct: 521 PVIQVPNNVTVTPGERAVLTCLIISAVDYNL--TWQRNDRDVRLAE--PARIRTLANLSL 576

Query: 289 IIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPV 348
            +  VK  D+G+Y C+ S S G S +AS +LTVQ P +V  MP       G    I C  
Sbjct: 577 ELKSVKFNDAGEYHCMVS-SEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSA 635

Query: 349 DAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQ 408
              P   +  W  +   + +  +  + +  DG++ I+ A  +  G Y C+  N+ GT  Q
Sbjct: 636 TGYPKPKIA-WTVN--DMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQ 692

Query: 409 SAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVG---KPSRSKH 465
           ++  R +  + P   V+   E     G   ++ C  +G P P + W K     +PS    
Sbjct: 693 NSTLRYI--EAPKLMVVQS-ELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLI 749

Query: 466 SALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSP---HAPGSVRVQVSM 522
                G L+ +     D G++ CVA N     T    L V G+ P     P  V +++  
Sbjct: 750 IDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDV-GSPPVFIQEPADVSMEIG- 807

Query: 523 TTANVSWEPGYDGGYEQTFSVWMK 546
             +NV+  P Y  GY +    W +
Sbjct: 808 --SNVTL-PCYVQGYPEPTIKWRR 828



 Score =  101 bits (251), Expect = 6e-21
 Identities = 117/470 (24%), Positives = 185/470 (39%), Gaps = 77/470 (16%)

Query: 53   GQPPPYVVEWFKFGVPI-----PIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSED 107
            G P P  + W+K G PI      ++I  G Y                   L + + +  D
Sbjct: 1573 GLPMP-AITWYKDGQPIMSSSQALYIDKGQY-------------------LHIPRAQVSD 1612

Query: 108  QGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTET--PPQYIEAKEGGSITMTCTAFG 165
               Y C V  +    +        H+ +  PP        P   +     S+T+ C A G
Sbjct: 1613 SATYTCHVANVAGTAEKSF-----HVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAG 1667

Query: 166  NPKPIVTWLKEGTLLGASGKYQVSDG--SLTVTSVSREDRGAYTCRAYSIQGEAVHTTHL 223
            NP PI+TWLK+G  + A+   ++  G   L + S    DRG Y C A S+ GE      +
Sbjct: 1668 NPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEV 1727

Query: 224  LVQGPPFIVSPPEN--ITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVR 281
             V  PP I    E     V ++    L C     P   T  W    + +    D +   +
Sbjct: 1728 DVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPP-TIMWLKDGQLI----DERDGFK 1782

Query: 282  ILIDG-TLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLN-----MPPVIY 335
            IL++G  L+I + +  ++G Y C+ +N+ G        +TV  P  + +        V Y
Sbjct: 1783 ILLNGRKLVIAQAQVSNTGLYRCMAANTAG-DHKKEFEVTVHVPPTIKSSGLSERVVVKY 1841

Query: 336  VPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTY 395
             PV     ++C  +  P  ++  W KD +P+   +           ++I +   E  G Y
Sbjct: 1842 KPVA----LQCIANGIPNPSIT-WLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRY 1896

Query: 396  TCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGREL----------LIPCAAA 445
            TCV  N  G   Q    +L + +PP           ++AG+ L           + C AA
Sbjct: 1897 TCVATNAAGETQQH--IQLHVHEPPSL---------EDAGKMLNETVLVSNPVQLECKAA 1945

Query: 446  GDPFPVITWRKVGK--PSRSKHSALPSGS-LQFRALSKEDHGEWECVATN 492
            G+P PVITW K  +     +  + L  G  +   +    D G ++CVA N
Sbjct: 1946 GNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAIN 1995



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 78/285 (27%), Positives = 122/285 (42%), Gaps = 34/285 (11%)

Query: 28   EEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYA 87
            E P  V+   GE + L C      TG P P +   F   +           P H D    
Sbjct: 4264 ELPGDVSLNKGEQLRLSCKA----TGIPLPKLTWTFNNNI----------IPAHFD---- 4305

Query: 88   GRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFT-ETPP 146
               S++  + L +E+V  ED G Y C     +          +V+  +  PP F  + P 
Sbjct: 4306 ---SVNGHSELVIERVSKEDSGTYVCTA---ENSVGFVKAIGFVY--VKEPPVFKGDYPS 4357

Query: 147  QYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKY-QVSDGSLTVTSVSREDRGA 205
             +IE   GG+  + C   G+P P + W ++G  +  S +  Q+ +GSL +     ED G 
Sbjct: 4358 NWIEPL-GGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGD 4416

Query: 206  YTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYW 265
            YTC A +  G    +  L +Q PP I   P    +N     +L C+A   P   T TW  
Sbjct: 4417 YTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEP-QPTITWSR 4475

Query: 266  QDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLG 310
            Q  ++ + +    RV +L + +L I   + ED+ ++ CV  N +G
Sbjct: 4476 QGHSISWDD----RVNVLSNNSLYIADAQKEDTSEFECVARNLMG 4516



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 48/190 (25%), Positives = 80/190 (42%), Gaps = 27/190 (14%)

Query: 38   GESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKAS 97
            G + +L C+V     G P P  ++W + GV I               E + R       S
Sbjct: 4364 GGNAILNCEV----KGDPTP-TIQWNRKGVDI---------------EISHRIRQLGNGS 4403

Query: 98   LRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSI 157
            L +    +ED G Y C   +   +         + LT+ +PP  T  P + +    GG I
Sbjct: 4404 LAIYGTVNEDAGDYTC---VATNEAGVVERS--MSLTLQSPPIITLEPVETV-INAGGKI 4457

Query: 158  TMTCTAFGNPKPIVTWLKEGTLLGASGKYQV-SDGSLTVTSVSREDRGAYTCRAYSIQGE 216
             + C A G P+P +TW ++G  +    +  V S+ SL +    +ED   + C A ++ G 
Sbjct: 4458 ILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGS 4517

Query: 217  AVHTTHLLVQ 226
             +    ++VQ
Sbjct: 4518 VLVRVPVIVQ 4527


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2a [Homo sapiens]
          Length = 1394

 Score =  155 bits (392), Expect = 2e-37
 Identities = 162/608 (26%), Positives = 256/608 (42%), Gaps = 52/608 (8%)

Query: 138 PPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGA------SGKYQVSDG 191
           PP   E P   I +K G   T+ C A G P P + W K+G  +        S +  +  G
Sbjct: 46  PPRIVEHPSDVIVSK-GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 104

Query: 192 SLTVTSV-----SREDRGAYTCRAYSIQGEAVH---TTHLLVQGPPFIVSPPENITVNIS 243
           SL    +     S+ D G+Y C A +  GEAV    +  + +    F  +P + + V   
Sbjct: 105 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTD-VVVAAG 163

Query: 244 QDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTC 303
           + A+L C+     G+   T YW+ + V   +D + R+ I   G L+I   +  D+G YTC
Sbjct: 164 EPAILECQPPR--GHPEPTIYWKKDKVRI-DDKEERISIR-GGKLMISNTRKSDAGMYTC 219

Query: 304 VPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDG 363
           V +N +G   S  A LTV      L  P    V        RC V  +P  T V+W KD 
Sbjct: 220 VGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPT-VRWKKDD 278

Query: 364 RPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFT 423
             L   +   + + +D ++RI++      GTY C+  N +G M   A A L ++ PP F 
Sbjct: 279 ADLPRGR---YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKM--EASATLTVRAPPQFV 333

Query: 424 VLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPS----------RSKHSALPSGSL 473
           V P  +   + GR +  PC   G+P P + W+K G  +           S+ S  P+G L
Sbjct: 334 VRPRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDL 392

Query: 474 QFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQ----VSMTTANVSW 529
               + + D G + C A  V  SI A   L V       P  + +Q     ++     + 
Sbjct: 393 TITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTAL 452

Query: 530 EPGYDGGYEQTFSVWMKRA-QFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKL 588
                 G       W+K    F   D  +     G   L +  L       ++ +A +  
Sbjct: 453 LKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGT--LQIKNLRISDTGTYTCVATSSS 510

Query: 589 GTSAFSEVVTVNTLAFPITTPEPLV-LVTPP-RCLIANRTQQGVLLSWLPPANHSFPIDR 646
           G +++S V+ V      I+    L  L  PP +  + + T+  V LSW P    + P   
Sbjct: 511 GETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASA 570

Query: 647 YIMEF---RVAERWELLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAG- 702
           YI+E     V+  W+ + + +  T   +  + L  +T Y F V A+    +S+PS ++  
Sbjct: 571 YIIEAFSQSVSNSWQTVANHVKTT--LYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDP 628

Query: 703 VSSTDIFP 710
           V + DI P
Sbjct: 629 VRTQDISP 636



 Score =  120 bits (301), Expect = 9e-27
 Identities = 177/738 (23%), Positives = 276/738 (37%), Gaps = 91/738 (12%)

Query: 28  EEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYA 87
           E P  V    GE   L C       G+P P  +EW+K G  +             D   +
Sbjct: 51  EHPSDVIVSKGEPTTLNCKA----EGRPTP-TIEWYKDGERVET---------DKDDPRS 96

Query: 88  GRASLHDKASLRLEQVRSE----DQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTE 143
            R  L   +   L  V       D+G Y C  +  +   +     + + + +     F +
Sbjct: 97  HRMLLPSGSLFFLRIVHGRRSKPDEGSYVC--VARNYLGEAVSRNASLEVAL-LRDDFRQ 153

Query: 144 TPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLG-ASGKYQVSDGSLTVTSVSRED 202
            P   + A    +I       G+P+P + W K+   +     +  +  G L +++  + D
Sbjct: 154 NPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSD 213

Query: 203 RGAYTCRAYSIQGEA-VHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTY 261
            G YTC   ++ GE       L V   P  +  P N  V   +     C+ +  P   T 
Sbjct: 214 AGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDP-QPTV 272

Query: 262 TWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTV 321
            W   D ++      + R  I  D TL I +    D G Y C+  N +G+   ASA LTV
Sbjct: 273 RWKKDDADLP-----RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKM-EASATLTV 326

Query: 322 QYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGR-----PLQVEK-NLGWT 375
           + P + +  P    V  G      C     P   V  W K+G      P Q ++ N   +
Sbjct: 327 RAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVF-WQKEGSQNLLFPNQPQQPNSRCS 385

Query: 376 LMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARL--VLKDPPYFTVLPGWEYRQE 433
           +   G + I        G Y C      G++   A   +  VL D P   +L G   +  
Sbjct: 386 VSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTL 445

Query: 434 A-GRELLIPCAAAGDPFPVITWRKVG--KPSRSKHSAL-PSGSLQFRALSKEDHGEWECV 489
           A     L+ C A GDP PVI+W K G   P R   + +   G+LQ + L   D G + CV
Sbjct: 446 AVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCV 505

Query: 490 ATNV--VTSITASTHLTVIGTS----------PHAPGSVRV-QVSMTTANVSWEPGYDGG 536
           AT+    TS +A   +T  G +          P  P   +V  V+  +  +SW+PG  G 
Sbjct: 506 ATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGT 565

Query: 537 YEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEV 596
              +  +    +Q   + W ++      +   V  L P T Y F V A N  G S  S  
Sbjct: 566 LPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPS-- 623

Query: 597 VTVNTLAFPITTPEPLVLVTPPRCLIANRTQQGVLLSWLPPANH-----------SFPID 645
                   P++ P     ++PP   + +R  Q  L   L   ++           ++ +D
Sbjct: 624 --------PMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVD 675

Query: 646 R---YIMEFRVAER----------WELLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQD 692
           R   +I  +RV  R          W+ LD  +P TE      +L +   YE +V     +
Sbjct: 676 RQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVP-TERSAVLVNLKKGVTYEIKVRPYFNE 734

Query: 693 LISEPSNIAGVSSTDIFP 710
                S    V +T+  P
Sbjct: 735 FQGMDSESKTVRTTEEAP 752



 Score =  101 bits (251), Expect = 6e-21
 Identities = 122/498 (24%), Positives = 195/498 (39%), Gaps = 58/498 (11%)

Query: 27  REEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEY 86
           R+ P  V   AGE  +L C    P  G P P  + W K  V I               + 
Sbjct: 152 RQNPTDVVVAAGEPAILEC---QPPRGHPEP-TIYWKKDKVRI--------------DDK 193

Query: 87  AGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPP 146
             R S+     L +   R  D G Y C    +  + D+        LT+   PTF   P 
Sbjct: 194 EERISIRG-GKLMISNTRKSDAGMYTCVGTNMVGERDS----DPAELTVFERPTFLRRPI 248

Query: 147 QYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDG-SLTVTSVSREDRGA 205
             +  +E  ++   C   G+P+P V W K+   L   G+Y + D  +L +      D G 
Sbjct: 249 NQVVLEE-EAVEFRCQVQGDPQPTVRWKKDDADL-PRGRYDIKDDYTLRIKKTMSTDEGT 306

Query: 206 YTCRAYSIQGEAVHTTHLLVQGPP-FIVSPPENITVNISQDALLTCRAEAYPGNLTYTWY 264
           Y C A +  G+   +  L V+ PP F+V P + I   ++Q   +T   E   GN     +
Sbjct: 307 YMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI---VAQGRTVTFPCET-KGNPQPAVF 362

Query: 265 WQDE---NVYFQNDLK---LRVRILIDGTLIIFRVKPEDSGKYTC----VPSNSLGRSP- 313
           WQ E   N+ F N  +    R  +   G L I  ++  D+G Y C    V  + L ++  
Sbjct: 363 WQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQL 422

Query: 314 SASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLG 373
             +  LT + P  +L  P    + V     ++C    + P  V+ W K+G      ++  
Sbjct: 423 EVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGD-PLPVISWLKEGFTFP-GRDPR 480

Query: 374 WTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQE 433
            T+ E G+++I+       GTYTCV  ++ G    SA   +        T+   ++    
Sbjct: 481 ATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGA---TISKNYDLSDL 537

Query: 434 AGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSKEDHGEWECVATNV 493
            G                ++W+  G P       LP+ +    A S+     W+ VA +V
Sbjct: 538 PGPPSKPQVTDVTKNSVTLSWQP-GTP-----GTLPASAYIIEAFSQSVSNSWQTVANHV 591

Query: 494 VTSITASTHLTVIGTSPH 511
            T++      TV G  P+
Sbjct: 592 KTTL-----YTVRGLRPN 604



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 51/195 (26%), Positives = 79/195 (40%), Gaps = 12/195 (6%)

Query: 26  LREEPEFVTARAGESVVLRCDVIHP--VTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVD 83
           +R  P+FV     + V     V  P    G P P V  W K G    +F       P+  
Sbjct: 326 VRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVF-WQKEGSQNLLF-------PNQP 377

Query: 84  PEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTE 143
            +   R S+     L +  ++  D G+Y C+ L +              +  + PP    
Sbjct: 378 QQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIIL 437

Query: 144 TPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEG-TLLGASGKYQVSD-GSLTVTSVSRE 201
             P        G+  + C A G+P P+++WLKEG T  G   +  + + G+L + ++   
Sbjct: 438 QGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRIS 497

Query: 202 DRGAYTCRAYSIQGE 216
           D G YTC A S  GE
Sbjct: 498 DTGTYTCVATSSSGE 512



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 49/190 (25%), Positives = 79/190 (41%), Gaps = 27/190 (14%)

Query: 323 YPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKN---LGWTLMED 379
           +P R++  P  + V  G    + C  +  P  T ++W KDG  ++ +K+       L+  
Sbjct: 45  FPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPT-IEWYKDGERVETDKDDPRSHRMLLPS 103

Query: 380 GS---IRIEEA--TEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQE- 433
           GS   +RI     ++   G+Y CV  N LG          V ++      L   ++RQ  
Sbjct: 104 GSLFFLRIVHGRRSKPDEGSYVCVARNYLG--------EAVSRNASLEVALLRDDFRQNP 155

Query: 434 ------AGRELLIPC-AAAGDPFPVITWR--KVGKPSRSKHSALPSGSLQFRALSKEDHG 484
                 AG   ++ C    G P P I W+  KV    + +  ++  G L      K D G
Sbjct: 156 TDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAG 215

Query: 485 EWECVATNVV 494
            + CV TN+V
Sbjct: 216 MYTCVGTNMV 225


>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2b [Homo sapiens]
          Length = 1378

 Score =  155 bits (392), Expect = 2e-37
 Identities = 162/608 (26%), Positives = 256/608 (42%), Gaps = 52/608 (8%)

Query: 138 PPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGA------SGKYQVSDG 191
           PP   E P   I +K G   T+ C A G P P + W K+G  +        S +  +  G
Sbjct: 30  PPRIVEHPSDVIVSK-GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 88

Query: 192 SLTVTSV-----SREDRGAYTCRAYSIQGEAVH---TTHLLVQGPPFIVSPPENITVNIS 243
           SL    +     S+ D G+Y C A +  GEAV    +  + +    F  +P + + V   
Sbjct: 89  SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTD-VVVAAG 147

Query: 244 QDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTC 303
           + A+L C+     G+   T YW+ + V   +D + R+ I   G L+I   +  D+G YTC
Sbjct: 148 EPAILECQPPR--GHPEPTIYWKKDKVRI-DDKEERISIR-GGKLMISNTRKSDAGMYTC 203

Query: 304 VPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDG 363
           V +N +G   S  A LTV      L  P    V        RC V  +P  T V+W KD 
Sbjct: 204 VGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPT-VRWKKDD 262

Query: 364 RPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFT 423
             L   +   + + +D ++RI++      GTY C+  N +G M   A A L ++ PP F 
Sbjct: 263 ADLPRGR---YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKM--EASATLTVRAPPQFV 317

Query: 424 VLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPS----------RSKHSALPSGSL 473
           V P  +   + GR +  PC   G+P P + W+K G  +           S+ S  P+G L
Sbjct: 318 VRPRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDL 376

Query: 474 QFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQ----VSMTTANVSW 529
               + + D G + C A  V  SI A   L V       P  + +Q     ++     + 
Sbjct: 377 TITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTAL 436

Query: 530 EPGYDGGYEQTFSVWMKRA-QFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKL 588
                 G       W+K    F   D  +     G   L +  L       ++ +A +  
Sbjct: 437 LKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGT--LQIKNLRISDTGTYTCVATSSS 494

Query: 589 GTSAFSEVVTVNTLAFPITTPEPLV-LVTPP-RCLIANRTQQGVLLSWLPPANHSFPIDR 646
           G +++S V+ V      I+    L  L  PP +  + + T+  V LSW P    + P   
Sbjct: 495 GETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASA 554

Query: 647 YIMEF---RVAERWELLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAG- 702
           YI+E     V+  W+ + + +  T   +  + L  +T Y F V A+    +S+PS ++  
Sbjct: 555 YIIEAFSQSVSNSWQTVANHVKTT--LYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDP 612

Query: 703 VSSTDIFP 710
           V + DI P
Sbjct: 613 VRTQDISP 620



 Score =  120 bits (301), Expect = 9e-27
 Identities = 177/738 (23%), Positives = 276/738 (37%), Gaps = 91/738 (12%)

Query: 28  EEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYA 87
           E P  V    GE   L C       G+P P  +EW+K G  +             D   +
Sbjct: 35  EHPSDVIVSKGEPTTLNCKA----EGRPTP-TIEWYKDGERVET---------DKDDPRS 80

Query: 88  GRASLHDKASLRLEQVRSE----DQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTE 143
            R  L   +   L  V       D+G Y C  +  +   +     + + + +     F +
Sbjct: 81  HRMLLPSGSLFFLRIVHGRRSKPDEGSYVC--VARNYLGEAVSRNASLEVAL-LRDDFRQ 137

Query: 144 TPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLG-ASGKYQVSDGSLTVTSVSRED 202
            P   + A    +I       G+P+P + W K+   +     +  +  G L +++  + D
Sbjct: 138 NPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSD 197

Query: 203 RGAYTCRAYSIQGEA-VHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTY 261
            G YTC   ++ GE       L V   P  +  P N  V   +     C+ +  P   T 
Sbjct: 198 AGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDP-QPTV 256

Query: 262 TWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTV 321
            W   D ++      + R  I  D TL I +    D G Y C+  N +G+   ASA LTV
Sbjct: 257 RWKKDDADLP-----RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKM-EASATLTV 310

Query: 322 QYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGR-----PLQVEK-NLGWT 375
           + P + +  P    V  G      C     P   V  W K+G      P Q ++ N   +
Sbjct: 311 RAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVF-WQKEGSQNLLFPNQPQQPNSRCS 369

Query: 376 LMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARL--VLKDPPYFTVLPGWEYRQE 433
           +   G + I        G Y C      G++   A   +  VL D P   +L G   +  
Sbjct: 370 VSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTL 429

Query: 434 A-GRELLIPCAAAGDPFPVITWRKVG--KPSRSKHSAL-PSGSLQFRALSKEDHGEWECV 489
           A     L+ C A GDP PVI+W K G   P R   + +   G+LQ + L   D G + CV
Sbjct: 430 AVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCV 489

Query: 490 ATNV--VTSITASTHLTVIGTS----------PHAPGSVRV-QVSMTTANVSWEPGYDGG 536
           AT+    TS +A   +T  G +          P  P   +V  V+  +  +SW+PG  G 
Sbjct: 490 ATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGT 549

Query: 537 YEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEV 596
              +  +    +Q   + W ++      +   V  L P T Y F V A N  G S  S  
Sbjct: 550 LPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPS-- 607

Query: 597 VTVNTLAFPITTPEPLVLVTPPRCLIANRTQQGVLLSWLPPANH-----------SFPID 645
                   P++ P     ++PP   + +R  Q  L   L   ++           ++ +D
Sbjct: 608 --------PMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVD 659

Query: 646 R---YIMEFRVAER----------WELLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQD 692
           R   +I  +RV  R          W+ LD  +P TE      +L +   YE +V     +
Sbjct: 660 RQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVP-TERSAVLVNLKKGVTYEIKVRPYFNE 718

Query: 693 LISEPSNIAGVSSTDIFP 710
                S    V +T+  P
Sbjct: 719 FQGMDSESKTVRTTEEAP 736



 Score =  101 bits (251), Expect = 6e-21
 Identities = 122/498 (24%), Positives = 195/498 (39%), Gaps = 58/498 (11%)

Query: 27  REEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEY 86
           R+ P  V   AGE  +L C    P  G P P  + W K  V I               + 
Sbjct: 136 RQNPTDVVVAAGEPAILEC---QPPRGHPEP-TIYWKKDKVRI--------------DDK 177

Query: 87  AGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPP 146
             R S+     L +   R  D G Y C    +  + D+        LT+   PTF   P 
Sbjct: 178 EERISIRG-GKLMISNTRKSDAGMYTCVGTNMVGERDS----DPAELTVFERPTFLRRPI 232

Query: 147 QYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDG-SLTVTSVSREDRGA 205
             +  +E  ++   C   G+P+P V W K+   L   G+Y + D  +L +      D G 
Sbjct: 233 NQVVLEE-EAVEFRCQVQGDPQPTVRWKKDDADL-PRGRYDIKDDYTLRIKKTMSTDEGT 290

Query: 206 YTCRAYSIQGEAVHTTHLLVQGPP-FIVSPPENITVNISQDALLTCRAEAYPGNLTYTWY 264
           Y C A +  G+   +  L V+ PP F+V P + I   ++Q   +T   E   GN     +
Sbjct: 291 YMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI---VAQGRTVTFPCET-KGNPQPAVF 346

Query: 265 WQDE---NVYFQNDLK---LRVRILIDGTLIIFRVKPEDSGKYTC----VPSNSLGRSP- 313
           WQ E   N+ F N  +    R  +   G L I  ++  D+G Y C    V  + L ++  
Sbjct: 347 WQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQL 406

Query: 314 SASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLG 373
             +  LT + P  +L  P    + V     ++C    + P  V+ W K+G      ++  
Sbjct: 407 EVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGD-PLPVISWLKEGFTFP-GRDPR 464

Query: 374 WTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQE 433
            T+ E G+++I+       GTYTCV  ++ G    SA   +        T+   ++    
Sbjct: 465 ATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGA---TISKNYDLSDL 521

Query: 434 AGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSKEDHGEWECVATNV 493
            G                ++W+  G P       LP+ +    A S+     W+ VA +V
Sbjct: 522 PGPPSKPQVTDVTKNSVTLSWQP-GTP-----GTLPASAYIIEAFSQSVSNSWQTVANHV 575

Query: 494 VTSITASTHLTVIGTSPH 511
            T++      TV G  P+
Sbjct: 576 KTTL-----YTVRGLRPN 588



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 51/195 (26%), Positives = 79/195 (40%), Gaps = 12/195 (6%)

Query: 26  LREEPEFVTARAGESVVLRCDVIHP--VTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVD 83
           +R  P+FV     + V     V  P    G P P V  W K G    +F       P+  
Sbjct: 310 VRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVF-WQKEGSQNLLF-------PNQP 361

Query: 84  PEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTE 143
            +   R S+     L +  ++  D G+Y C+ L +              +  + PP    
Sbjct: 362 QQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIIL 421

Query: 144 TPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEG-TLLGASGKYQVSD-GSLTVTSVSRE 201
             P        G+  + C A G+P P+++WLKEG T  G   +  + + G+L + ++   
Sbjct: 422 QGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRIS 481

Query: 202 DRGAYTCRAYSIQGE 216
           D G YTC A S  GE
Sbjct: 482 DTGTYTCVATSSSGE 496



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 49/190 (25%), Positives = 79/190 (41%), Gaps = 27/190 (14%)

Query: 323 YPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKN---LGWTLMED 379
           +P R++  P  + V  G    + C  +  P  T ++W KDG  ++ +K+       L+  
Sbjct: 29  FPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPT-IEWYKDGERVETDKDDPRSHRMLLPS 87

Query: 380 GS---IRIEEA--TEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQE- 433
           GS   +RI     ++   G+Y CV  N LG          V ++      L   ++RQ  
Sbjct: 88  GSLFFLRIVHGRRSKPDEGSYVCVARNYLG--------EAVSRNASLEVALLRDDFRQNP 139

Query: 434 ------AGRELLIPC-AAAGDPFPVITWR--KVGKPSRSKHSALPSGSLQFRALSKEDHG 484
                 AG   ++ C    G P P I W+  KV    + +  ++  G L      K D G
Sbjct: 140 TDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAG 199

Query: 485 EWECVATNVV 494
            + CV TN+V
Sbjct: 200 MYTCVGTNMV 209


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score =  154 bits (389), Expect = 6e-37
 Identities = 157/624 (25%), Positives = 248/624 (39%), Gaps = 82/624 (13%)

Query: 138 PPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGA------SGKYQVSDG 191
           PP   E P   I +K G   T+ C A G P P + W K G  +        S +  +  G
Sbjct: 28  PPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 192 SLTVTSV-----SREDRGAYTCRAYSIQGEAVH---TTHLLVQGPPFIVSPPENITVNIS 243
           SL    +     SR D G Y C A +  GEAV    +  + +    F  +P + + V + 
Sbjct: 87  SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD-VMVAVG 145

Query: 244 QDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTC 303
           + A++ C+        T +W  +D +     D ++ +R    G L+I   +  D+GKY C
Sbjct: 146 EPAVMECQPPRGHPEPTISWK-KDGSPLDDKDERITIR---GGKLMITYTRKSDAGKYVC 201

Query: 304 VPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDG 363
           V +N +G   S  A LTV      +  P  + V V      +C    +P  TV +W KD 
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTV-RWRKDD 260

Query: 364 RPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFT 423
             L   +   + + +D +++I + T   +G+YTCV  N +G     A A L +++PP+F 
Sbjct: 261 GELPKSR---YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA--EASATLTVQEPPHFV 315

Query: 424 VLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGK----------PSRSKHSALPSGSL 473
           V P  +     GR +   C A G+P P I WR+ G            S S+ S   +G L
Sbjct: 316 VKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 374

Query: 474 QFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQ--VSMTTA------ 525
               + + D G + C   NV  SI    +L V       P  V  Q  V+ T A      
Sbjct: 375 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 434

Query: 526 -----------NVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEP 574
                       + W    DG    T    +K+ + G               L +   + 
Sbjct: 435 LSCVATGSPVPTILWRK--DGVLVSTQDSRIKQLENGV--------------LQIRYAKL 478

Query: 575 ETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEP----LVLVTPPRCLIANRTQQGV 630
               +++ +A    G + +S  + V     P+  P P    L+   P +  + + ++  V
Sbjct: 479 GDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTV 538

Query: 631 LLSWLPPANHSFPIDRYIME---FRVAERWELLDDGIPGTEGEFFAKDLSQDTWYEFRVL 687
            LSW P  N       YI+E         W+ + + +         K L  +  Y F V 
Sbjct: 539 TLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAI--KGLKPNAIYLFLVR 596

Query: 688 AVMQDLISEPSNIAG-VSSTDIFP 710
           A     IS+PS I+  V + D+ P
Sbjct: 597 AANAYGISDPSQISDPVKTQDVLP 620



 Score = 97.4 bits (241), Expect = 8e-20
 Identities = 153/668 (22%), Positives = 237/668 (35%), Gaps = 96/668 (14%)

Query: 27  REEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEY 86
           R+ P  V    GE  V+ C    P  G P P  + W K G P+               + 
Sbjct: 134 RQNPSDVMVAVGEPAVMECQ---PPRGHPEP-TISWKKDGSPLD--------------DK 175

Query: 87  AGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPP 146
             R ++     L +   R  D G Y C    +  + ++        LT+   P+F + P 
Sbjct: 176 DERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERES----EVAELTVLERPSFVKRPS 230

Query: 147 QYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQV-SDGSLTVTSVSREDRGA 205
             +      S    C A G+P P V W K+   L  S +Y++  D +L +  V+  D G+
Sbjct: 231 N-LAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGS 288

Query: 206 YTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYW 265
           YTC A ++ G+A  +  L VQ PP  V  P +  V + +     C A    GN     +W
Sbjct: 289 YTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEA---TGNPQPAIFW 345

Query: 266 QDEN------VYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYL 319
           + E        Y       R  +   G L I  V+  D G Y C   N  G S    AYL
Sbjct: 346 RREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG-SIITKAYL 404

Query: 320 TV-----QYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGW 374
            V       P  V+   PV         ++   V    P   + W KDG  L   ++   
Sbjct: 405 EVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG-VLVSTQDSRI 463

Query: 375 TLMEDGSIRIEEATEEALGTYTCV-------------------------PYNTLGTMGQS 409
             +E+G ++I  A     G YTC+                         P  T   +  S
Sbjct: 464 KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPS 523

Query: 410 APARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSAL- 468
           AP++  + D    TV   W+    +G         A       +W+ V +  +++ SA+ 
Sbjct: 524 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIK 583

Query: 469 ---PSGSLQF--RALSKEDHGEWECVATNVVTSITASTHLTV--------IGTSP---HA 512
              P+    F  RA +     +   ++  V T     T   V        +G +    H 
Sbjct: 584 GLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHN 643

Query: 513 PGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMK--RAQFGPHDWLSLPV-PPGPSWLLV 569
           P      +S ++  V W       Y Q + +  +   A  G  DWL   V  P  + +++
Sbjct: 644 P----TVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVI 699

Query: 570 DTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEPLVLVTPPRCLIANRTQQG 629
             L     Y+            A SE+    TL    + P   V V+       +     
Sbjct: 700 PDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSK-----NDGNGTA 754

Query: 630 VLLSWLPP 637
           +L+SW PP
Sbjct: 755 ILVSWQPP 762



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 59/229 (25%), Positives = 92/229 (40%), Gaps = 20/229 (8%)

Query: 26  LREEPEFVT------ARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYP 79
           ++E P FV          G +V  +C+     TG P P +  W + G      + F Y P
Sbjct: 308 VQEPPHFVVKPRDQVVALGRTVTFQCEA----TGNPQPAIF-WRREGSQN---LLFSYQP 359

Query: 80  PHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPP 139
           P    + + R S+     L +  V+  D G+Y C+ L +     T        +  + PP
Sbjct: 360 P----QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 415

Query: 140 TFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKY--QVSDGSLTVTS 197
                 P        G+  ++C A G+P P + W K+G L+        Q+ +G L +  
Sbjct: 416 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 475

Query: 198 VSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDA 246
               D G YTC A +  GEA  + ++ VQ     V PP     N+   A
Sbjct: 476 AKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSA 524



 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 51/194 (26%), Positives = 82/194 (42%), Gaps = 17/194 (8%)

Query: 314 SASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKN-- 371
           S S      +P R++  P  + V  G    + C  +  P  T ++W K G  ++ +K+  
Sbjct: 18  SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT-IEWYKGGERVETDKDDP 76

Query: 372 -LGWTLMEDGS---IRIEEATEEA--LGTYTCVPYNTLG-TMGQSAPARL-VLKDPPYFT 423
                L+  GS   +RI    +     G Y CV  N LG  +  +A   + +L+D   F 
Sbjct: 77  RSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD--FR 134

Query: 424 VLPGWEYRQEAGRELLIPC-AAAGDPFPVITWRKVGKP--SRSKHSALPSGSLQFRALSK 480
             P  +     G   ++ C    G P P I+W+K G P   + +   +  G L      K
Sbjct: 135 QNPS-DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRK 193

Query: 481 EDHGEWECVATNVV 494
            D G++ CV TN+V
Sbjct: 194 SDAGKYVCVGTNMV 207


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score =  154 bits (389), Expect = 6e-37
 Identities = 157/624 (25%), Positives = 248/624 (39%), Gaps = 82/624 (13%)

Query: 138 PPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGA------SGKYQVSDG 191
           PP   E P   I +K G   T+ C A G P P + W K G  +        S +  +  G
Sbjct: 67  PPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 125

Query: 192 SLTVTSV-----SREDRGAYTCRAYSIQGEAVH---TTHLLVQGPPFIVSPPENITVNIS 243
           SL    +     SR D G Y C A +  GEAV    +  + +    F  +P + + V + 
Sbjct: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD-VMVAVG 184

Query: 244 QDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTC 303
           + A++ C+        T +W  +D +     D ++ +R    G L+I   +  D+GKY C
Sbjct: 185 EPAVMECQPPRGHPEPTISWK-KDGSPLDDKDERITIR---GGKLMITYTRKSDAGKYVC 240

Query: 304 VPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDG 363
           V +N +G   S  A LTV      +  P  + V V      +C    +P  TV +W KD 
Sbjct: 241 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTV-RWRKDD 299

Query: 364 RPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFT 423
             L   +   + + +D +++I + T   +G+YTCV  N +G     A A L +++PP+F 
Sbjct: 300 GELPKSR---YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA--EASATLTVQEPPHFV 354

Query: 424 VLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGK----------PSRSKHSALPSGSL 473
           V P  +     GR +   C A G+P P I WR+ G            S S+ S   +G L
Sbjct: 355 VKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 413

Query: 474 QFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQ--VSMTTA------ 525
               + + D G + C   NV  SI    +L V       P  V  Q  V+ T A      
Sbjct: 414 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 473

Query: 526 -----------NVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEP 574
                       + W    DG    T    +K+ + G               L +   + 
Sbjct: 474 LSCVATGSPVPTILWRK--DGVLVSTQDSRIKQLENGV--------------LQIRYAKL 517

Query: 575 ETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEP----LVLVTPPRCLIANRTQQGV 630
               +++ +A    G + +S  + V     P+  P P    L+   P +  + + ++  V
Sbjct: 518 GDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTV 577

Query: 631 LLSWLPPANHSFPIDRYIME---FRVAERWELLDDGIPGTEGEFFAKDLSQDTWYEFRVL 687
            LSW P  N       YI+E         W+ + + +         K L  +  Y F V 
Sbjct: 578 TLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAI--KGLKPNAIYLFLVR 635

Query: 688 AVMQDLISEPSNIAG-VSSTDIFP 710
           A     IS+PS I+  V + D+ P
Sbjct: 636 AANAYGISDPSQISDPVKTQDVLP 659



 Score = 97.4 bits (241), Expect = 8e-20
 Identities = 153/668 (22%), Positives = 237/668 (35%), Gaps = 96/668 (14%)

Query: 27  REEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEY 86
           R+ P  V    GE  V+ C    P  G P P  + W K G P+               + 
Sbjct: 173 RQNPSDVMVAVGEPAVMECQ---PPRGHPEP-TISWKKDGSPLD--------------DK 214

Query: 87  AGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPP 146
             R ++     L +   R  D G Y C    +  + ++        LT+   P+F + P 
Sbjct: 215 DERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERES----EVAELTVLERPSFVKRPS 269

Query: 147 QYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQV-SDGSLTVTSVSREDRGA 205
             +      S    C A G+P P V W K+   L  S +Y++  D +L +  V+  D G+
Sbjct: 270 N-LAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGS 327

Query: 206 YTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYW 265
           YTC A ++ G+A  +  L VQ PP  V  P +  V + +     C A    GN     +W
Sbjct: 328 YTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEA---TGNPQPAIFW 384

Query: 266 QDEN------VYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYL 319
           + E        Y       R  +   G L I  V+  D G Y C   N  G S    AYL
Sbjct: 385 RREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG-SIITKAYL 443

Query: 320 TV-----QYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGW 374
            V       P  V+   PV         ++   V    P   + W KDG  L   ++   
Sbjct: 444 EVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG-VLVSTQDSRI 502

Query: 375 TLMEDGSIRIEEATEEALGTYTCV-------------------------PYNTLGTMGQS 409
             +E+G ++I  A     G YTC+                         P  T   +  S
Sbjct: 503 KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPS 562

Query: 410 APARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSAL- 468
           AP++  + D    TV   W+    +G         A       +W+ V +  +++ SA+ 
Sbjct: 563 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIK 622

Query: 469 ---PSGSLQF--RALSKEDHGEWECVATNVVTSITASTHLTV--------IGTSP---HA 512
              P+    F  RA +     +   ++  V T     T   V        +G +    H 
Sbjct: 623 GLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHN 682

Query: 513 PGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMK--RAQFGPHDWLSLPV-PPGPSWLLV 569
           P      +S ++  V W       Y Q + +  +   A  G  DWL   V  P  + +++
Sbjct: 683 P----TVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVI 738

Query: 570 DTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEPLVLVTPPRCLIANRTQQG 629
             L     Y+            A SE+    TL    + P   V V+       +     
Sbjct: 739 PDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSK-----NDGNGTA 793

Query: 630 VLLSWLPP 637
           +L+SW PP
Sbjct: 794 ILVSWQPP 801



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 59/229 (25%), Positives = 92/229 (40%), Gaps = 20/229 (8%)

Query: 26  LREEPEFVT------ARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYP 79
           ++E P FV          G +V  +C+     TG P P +  W + G      + F Y P
Sbjct: 347 VQEPPHFVVKPRDQVVALGRTVTFQCEA----TGNPQPAIF-WRREGSQN---LLFSYQP 398

Query: 80  PHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPP 139
           P    + + R S+     L +  V+  D G+Y C+ L +     T        +  + PP
Sbjct: 399 P----QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 454

Query: 140 TFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKY--QVSDGSLTVTS 197
                 P        G+  ++C A G+P P + W K+G L+        Q+ +G L +  
Sbjct: 455 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 514

Query: 198 VSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDA 246
               D G YTC A +  GEA  + ++ VQ     V PP     N+   A
Sbjct: 515 AKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSA 563



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 19/201 (9%)

Query: 307 NSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPL 366
           NSLG +   S      +P R++  P  + V  G    + C  +  P  T ++W K G  +
Sbjct: 52  NSLGYT--GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT-IEWYKGGERV 108

Query: 367 QVEKN---LGWTLMEDGS---IRIEEATEEA--LGTYTCVPYNTLG-TMGQSAPARL-VL 416
           + +K+       L+  GS   +RI    +     G Y CV  N LG  +  +A   + +L
Sbjct: 109 ETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL 168

Query: 417 KDPPYFTVLPGWEYRQEAGRELLIPC-AAAGDPFPVITWRKVGKP--SRSKHSALPSGSL 473
           +D   F   P  +     G   ++ C    G P P I+W+K G P   + +   +  G L
Sbjct: 169 RDD--FRQNPS-DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKL 225

Query: 474 QFRALSKEDHGEWECVATNVV 494
                 K D G++ CV TN+V
Sbjct: 226 MITYTRKSDAGKYVCVGTNMV 246


>gi|83281200 protogenin [Homo sapiens]
          Length = 1150

 Score =  153 bits (387), Expect = 9e-37
 Identities = 153/577 (26%), Positives = 252/577 (43%), Gaps = 42/577 (7%)

Query: 146 PQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQV-SDGSLTVTSVS----- 199
           PQ +       + + C A G     VTWLK G  +  + + +V S+GSL ++ V      
Sbjct: 45  PQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGE 104

Query: 200 REDRGAYTCRAYSIQGEAV-HTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGN 258
           + D G Y C A +  G  +    HL +         P +  V+    A   C+  ++P  
Sbjct: 105 QSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISSHPPA 164

Query: 259 LTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAY 318
           +  TW +    +    D   R+  L  G L I+ V   DSG Y C+ +    R  S  A 
Sbjct: 165 VI-TWEFNRTTLPMTMD---RITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEAS 220

Query: 319 LTVQYPARV---LNMPPVIYVPVGIHGYIRCPVDAEPPAT-----VVKWNK-DGRPLQVE 369
           LTV  PA+     + P +I  P  I   +   V  E  AT     ++ W++ D + + V 
Sbjct: 221 LTV-IPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDV- 278

Query: 370 KNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQS-APARLVLKDPPYFTVLPGW 428
                 ++ +G++ I +   +  G Y C    T GT   + A A L +  PP F   P  
Sbjct: 279 --FNTRVLGNGNLMISDVRLQHAGVYVCRA-TTPGTRNFTVAMATLTVLAPPSFVEWPES 335

Query: 429 EYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSK-HSALPSGSLQFRALSKEDHGEWE 487
             R  AG    + C A G P P ++W K G+   S     + +  L    +  ED   ++
Sbjct: 336 LTRPRAGTARFV-CQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQ 394

Query: 488 CVATNVVTSITASTHLTVIGTS--PHAPGSVRVQVSMTTANV-SWE-PGYDGGYEQTFSV 543
           C+A N   SI +   LTV+ +   P AP +V  +   ++A + +WE P Y+      +SV
Sbjct: 395 CMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSV 454

Query: 544 WMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLA 603
              +A+   ++   + +    +  ++D LEP + Y F ++A   +G S  S+ VT NTL 
Sbjct: 455 HYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLE 514

Query: 604 FPITTPEPLVLVTPPRCLIANRTQQGVLLSWLP-PANH-SFPIDRYIMEFRVAERWELLD 661
                    V + PP   + +R+   +L+SWLP PA +    +  Y + FR++    +  
Sbjct: 515 D--------VPLRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQV 566

Query: 662 DGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPS 698
             +PGT  E+  + L  D+ Y  R+ A  +  + E S
Sbjct: 567 LELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESS 603



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 99/404 (24%), Positives = 159/404 (39%), Gaps = 43/404 (10%)

Query: 28  EEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYA 87
           +EP+ VT    + VVL C     V     P  V W K G  +            ++    
Sbjct: 43  KEPQDVTVTRKDPVVLDCQAHGEV-----PIKVTWLKNGAKMS-------ENKRIEVLSN 90

Query: 88  GRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQ 147
           G   + +    R EQ    D+G+Y+C  +    +Y    +    HL ++    F E  P 
Sbjct: 91  GSLYISEVEGRRGEQ---SDEGFYQCLAM---NKYGAILSQK-AHLALSTISAF-EVQPI 142

Query: 148 YIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGK--YQVSDGSLTVTSVSREDRGA 205
             E  EGG     C    +P  ++TW    T L  +      +  G L +  VS+ D G 
Sbjct: 143 STEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGN 202

Query: 206 YTCRAYSIQGEAVHTTHLLVQGP---------PFIVSPPENITVNISQDALLTCRAEAYP 256
           Y C A ++          L   P         P I++ P+NIT ++ Q  +L C A   P
Sbjct: 203 YRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNP 262

Query: 257 GNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRS-PSA 315
             +  +W   D     ++      R+L +G L+I  V+ + +G Y C  +    R+   A
Sbjct: 263 KPI-ISWSRLDH----KSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVA 317

Query: 316 SAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEP-PATVVKWNKDGRPLQVEKNLGW 374
            A LTV  P   +  P  +  P    G  R    AE  P+  + W K+GR +    + G 
Sbjct: 318 MATLTVLAPPSFVEWPESLTRPRA--GTARFVCQAEGIPSPKMSWLKNGRKIH---SNGR 372

Query: 375 TLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKD 418
             M +  + I +   E    Y C+  N+ G++   A   +V+ +
Sbjct: 373 IKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSE 416



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 55/221 (24%), Positives = 91/221 (41%), Gaps = 27/221 (12%)

Query: 30  PEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFG-VPIPIFIKFGYYPPHVDPEYAG 88
           P+ +T    ++VVL C      TG P P ++ W +     I +F                
Sbjct: 241 PQNITTSLHQTVVLEC----MATGNPKP-IISWSRLDHKSIDVF---------------- 279

Query: 89  RASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQY 148
              +    +L +  VR +  G Y C+      +  T    +   LT+ APP+F E P + 
Sbjct: 280 NTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTV---AMATLTVLAPPSFVEWP-ES 335

Query: 149 IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSREDRGAYTC 208
           +     G+    C A G P P ++WLK G  + ++G+ ++ +  L +  +  ED   Y C
Sbjct: 336 LTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQC 395

Query: 209 RAYSIQGEAVHTTHLLVQGPPFIVSPPENI-TVNISQDALL 248
            A + QG  +    L V       S P N+    +S  A+L
Sbjct: 396 MAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAIL 436



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 30/91 (32%), Positives = 42/91 (46%), Gaps = 7/91 (7%)

Query: 567 LLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEPLVLVTPPRCLIANRT 626
           +LV  LEP T Y+F+V       +S +S VV  +TL      P   V VT    LI + T
Sbjct: 780 MLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVT----LIEDDT 835

Query: 627 QQGVLLSWLPPANHSFPIDRYIMEFRVAERW 657
               L+SW PP      + RY + +   + W
Sbjct: 836 ---ALVSWKPPDGPETVVTRYTILYASRKAW 863


>gi|7657361 contactin 6 [Homo sapiens]
          Length = 1028

 Score =  152 bits (385), Expect = 2e-36
 Identities = 157/590 (26%), Positives = 242/590 (41%), Gaps = 60/590 (10%)

Query: 33  VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
           V+ R G+ VVL C         PPP+      FG  +     F   P +V  +     S 
Sbjct: 132 VSVREGQGVVLLCG--------PPPH------FG-DLSYAWTFNDNPLYVQEDNRRFVS- 175

Query: 93  HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQY---- 148
            +  +L + +V   D G Y C +   + Q      G    L         E  P+     
Sbjct: 176 QETGNLYIAKVEPSDVGNYTCFITNKEAQRSV--QGPPTPLVQRTDGVMGEYEPKIEVRF 233

Query: 149 ---IEAKEGGSITMTCTAFGNPKPIVTWLK-EGTLLGASGKYQVSDGSLTVTSVSREDRG 204
              I+A +  S+ + C A GNP P ++W + +G+ L    KY  S   L + +  +ED G
Sbjct: 234 PETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEG 293

Query: 205 AYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWY 264
            Y C A +++G  +    L+   PP      +N  ++I  + L  C+A   P N  YTW 
Sbjct: 294 FYECIASNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKP-NPWYTWL 352

Query: 265 WQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
              E +  +  +++      +GTLII  +   DSG Y C   N   +   A+A L V   
Sbjct: 353 KNGERLNPEERIQIE-----NGTLIITMLNVSDSGVYQCAAENKY-QIIYANAELRVLAS 406

Query: 325 ARVLNMPPV---IYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGS 381
           A   +  PV    +V VG    I C  +A P A +  W +    L+  K +   L+EDGS
Sbjct: 407 APDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAI-SWKRGTETLRQSKRI--FLLEDGS 463

Query: 382 IRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIP 441
           ++I   T    G+YTC+  N  GT   +    L++K+    TV P  +     G  +++P
Sbjct: 464 LKIYNITRSDAGSYTCIATNQFGTAKNTGS--LIVKERTVITVPPS-KMDVTVGESIVLP 520

Query: 442 CAAAGDPF--PVITW--------RKVGKPSRSKHSALPSGSLQFRALSKEDHGEWECVAT 491
           C  + DP    V  W         K G     +      G L  R +     G++ C   
Sbjct: 521 CQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQ 580

Query: 492 NVVTSITASTHLTVIGTSPHAPGSVRVQ-VSMTTANVSWEPGYDGGYEQTFSVWMKRAQF 550
             + S++A   + V G  P  P  V+V+ +S TT+ +SW  G D            R  F
Sbjct: 581 TTLESLSAVADIIVRGP-PGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPF 639

Query: 551 GPHDWLSLPVPP----GPSW-LLVDTLEPETAYQFSVLAQNKLGTSAFSE 595
               W ++   P    G ++   V  L P   Y+F V+A N +G    SE
Sbjct: 640 SV-GWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSE 688



 Score =  108 bits (269), Expect = 5e-23
 Identities = 105/402 (26%), Positives = 169/402 (42%), Gaps = 48/402 (11%)

Query: 30  PEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKF-GVPIPIFIKFGYYPPHVDPEYAG 88
           PE + A    SV L C  +    G P P +  W +  G P+P  +K+             
Sbjct: 234 PETIQAAKDSSVKLECFAL----GNPVPDI-SWRRLDGSPLPGKVKYS------------ 276

Query: 89  RASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQY 148
                 +A L +   + ED+G+YEC    L  +     N +   L   APP + E   Q 
Sbjct: 277 ----KSQAILEIPNFQQEDEGFYECIASNLRGR-----NLAKGQLIFYAPPEW-EQKIQN 326

Query: 149 IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSREDRGAYTC 208
                  ++   C A G P P  TWLK G  L    + Q+ +G+L +T ++  D G Y C
Sbjct: 327 THLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEERIQIENGTLIITMLNVSDSGVYQC 386

Query: 209 RA---YSIQGEAVHTTHLLVQGPPFIVSPPENIT-VNISQDALLTCRAEAYPGNLTYTWY 264
            A   Y I   A     +L   P F  SP +  + V +  D ++ C+  A+P     +W 
Sbjct: 387 AAENKYQII-YANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFP-RAAISWK 444

Query: 265 WQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
              E +        R+ +L DG+L I+ +   D+G YTC+ +N  G + +  + +  +  
Sbjct: 445 RGTETLRQSK----RIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKE-- 498

Query: 325 ARVLNMPP-VIYVPVGIHGYIRCPVDAEPPATVV-KWNKDGRPLQVEKNLGWTLM----E 378
             V+ +PP  + V VG    + C V  +P   VV  W  +G  + ++K +          
Sbjct: 499 RTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGES 558

Query: 379 DGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPP 420
            G + I        G Y C    TL ++  SA A ++++ PP
Sbjct: 559 VGDLMIRNIQLHHSGKYLCTVQTTLESL--SAVADIIVRGPP 598



 Score =  102 bits (253), Expect = 3e-21
 Identities = 104/409 (25%), Positives = 163/409 (39%), Gaps = 63/409 (15%)

Query: 139 PTFTETPPQYIEAKE--GGSITMTCTAFGNPKPIVTWLKEGTLLG--ASGKYQVSDGSLT 194
           P FT+ P   I   +     + + C A G P P   W + GT +    S  Y++  GSL 
Sbjct: 26  PIFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDGGSLA 85

Query: 195 VTSV-SREDRGAYTCRAYSIQGEAVHTTHLLVQG--PPFIVSPPENITVNISQDALLTCR 251
           + S  + +D G Y C A ++ G  +     L       F       ++V   Q  +L C 
Sbjct: 86  INSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCG 145

Query: 252 AEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGR 311
              + G+L+Y W + D  +Y Q D + R      G L I +V+P D G YTC  +N    
Sbjct: 146 PPPHFGDLSYAWTFNDNPLYVQEDNR-RFVSQETGNLYIAKVEPSDVGNYTCFITNK--- 201

Query: 312 SPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATV--------------- 356
                A  +VQ P       P++    G+ G     ++   P T+               
Sbjct: 202 ----EAQRSVQGPP-----TPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFAL 252

Query: 357 ------VKWNK-DGRPL--QVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMG 407
                 + W + DG PL  +V+ +    ++E     I    +E  G Y C+  N  G   
Sbjct: 253 GNPVPDISWRRLDGSPLPGKVKYSKSQAILE-----IPNFQQEDEGFYECIASNLRG--- 304

Query: 408 QSAPARLVLKDPPYFTVLPGWEYRQEAGR-----ELLIPCAAAGDPFPVITWRKVG-KPS 461
                R + K    F   P WE + +         LL  C A+G P P  TW K G + +
Sbjct: 305 -----RNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLN 359

Query: 462 RSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSP 510
             +   + +G+L    L+  D G ++C A N    I A+  L V+ ++P
Sbjct: 360 PEERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAP 408


>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
          Length = 1215

 Score =  152 bits (384), Expect = 2e-36
 Identities = 152/524 (29%), Positives = 208/524 (39%), Gaps = 50/524 (9%)

Query: 63  FKFGVPIPIFIKFGYYP-PHVDPEYAGRASLHD-------KASLRLEQVRSEDQGWYECK 114
           F  GV + +      YP PH+      +A   D       + +L ++ V  ED G Y C+
Sbjct: 502 FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQ 561

Query: 115 VLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWL 174
                   +   +   V L    PP+ +      + A  G    + C A G P P V W 
Sbjct: 562 ATN-----EVGTDQETVTLYYTDPPSVSAVNAVVLVAV-GEEAVLVCEASGVPPPRVIWY 615

Query: 175 KEGT--LLGASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIV 232
           + G   +L   G    S G L + +    D G YTCRA +  G+A     L V   P + 
Sbjct: 616 RGGLEMILAPEGS---SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLT 672

Query: 233 SPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKL------RVRILIDG 286
             P ++TV + + ALL CRA   P   T TW   D        L+L      R R    G
Sbjct: 673 ELPRDVTVELGRSALLACRATGRPPP-TVTWRRGDGQPL---GLRLGAGRGSRSRQPDSG 728

Query: 287 TLIIFRVKPEDSGKYTCVPSNSLGR-SPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIR 345
            L    V PED   Y C   N  G+    A   +T   P ++ +  P + V  G    + 
Sbjct: 729 VLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLP 788

Query: 346 CPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGT 405
           C V A  P     W KDGRPL        ++  DGS+ ++ A +E  G Y+CV  NT G+
Sbjct: 789 CIVLAGRPLPERHWLKDGRPLPPGSR--HSIRADGSLHLDRALQEHAGRYSCVATNTAGS 846

Query: 406 MGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSK- 464
             Q     LV++ PP            E G    +PC A+G P P ITW K      S+ 
Sbjct: 847 --QHRDVELVVQVPPRIHPTATHHITNE-GVPASLPCVASGVPAPTITWTKETNALTSRG 903

Query: 465 --HSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSP--HAPGSVRVQV 520
             ++    G+L     S +D G + C ATN V   +    L+V  T P  H  GS     
Sbjct: 904 PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV-NTKPRIHMNGS----- 957

Query: 521 SMTTANVSWEPGYDGGYEQTFSVWMKRAQFGPHDWL--SLPVPP 562
               ANV  +     G E T     K +      W   S PVPP
Sbjct: 958 --RNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPP 999



 Score =  147 bits (370), Expect = 9e-35
 Identities = 137/505 (27%), Positives = 212/505 (41%), Gaps = 56/505 (11%)

Query: 33   VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
            V    GE  VL C+     +G PPP V+ W++ G+ + +            PE  G +S 
Sbjct: 590  VLVAVGEEAVLVCEA----SGVPPPRVI-WYRGGLEMILA-----------PE--GSSS- 630

Query: 93   HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAK 152
                 LR+   +  D G Y C+ +      +     + + L +   P  TE P   +  +
Sbjct: 631  ---GKLRIPAAQERDAGTYTCRAVN-----ELGDASAEIQLAVGHAPQLTELPRD-VTVE 681

Query: 153  EGGSITMTCTAFGNPKPIVTWLKE-----GTLLGA---SGKYQVSDGSLTVTSVSREDRG 204
             G S  + C A G P P VTW +      G  LGA   S   Q   G L   SV+ ED+ 
Sbjct: 682  LGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQA 741

Query: 205  AYTCRAYSIQGEAVHTTHLLVQG--PPFIVSPPENITVNISQDALLTCRAEAYPGNLTYT 262
             Y C A ++ G+      L+V G  PP I S    + V   Q   L C   A  G     
Sbjct: 742  PYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLA--GRPLPE 799

Query: 263  WYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQ 322
             +W  +        +  +R   DG+L + R   E +G+Y+CV +N+ G S      L VQ
Sbjct: 800  RHWLKDGRPLPPGSRHSIRA--DGSLHLDRALQEHAGRYSCVATNTAG-SQHRDVELVVQ 856

Query: 323  YPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSI 382
             P R+           G+   + C V +  PA  + W K+   L   +   + + ++G++
Sbjct: 857  VPPRIHPTATHHITNEGVPASLPC-VASGVPAPTITWTKETNAL-TSRGPHYNVSKEGTL 914

Query: 383  RIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPG------WEYRQEAGR 436
             I + + +  G Y C   NT+G   Q    RL +   P   +          +   +AG 
Sbjct: 915  LIAQPSAQDAGAYVCTATNTVGFSSQEM--RLSVNTKPRIHMNGSRNANVPLQVTAKAGE 972

Query: 437  ELLIPCAAAGDPFPVITWRKVGKPS---RSKHSALPSGSLQFRALSKEDHGEWECVATNV 493
            E+ + C A G P P++TW K  +P     +++  LPSGSL+   +   D G +EC A+N 
Sbjct: 973  EVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNP 1032

Query: 494  VTSITASTHLTVIGTSPHAPGSVRV 518
              S +    L V G +   P S+ V
Sbjct: 1033 AGSASHRYVLGVQGRTSWQPQSLPV 1057



 Score =  146 bits (369), Expect = 1e-34
 Identities = 139/478 (29%), Positives = 204/478 (42%), Gaps = 57/478 (11%)

Query: 142 TETPPQYIEAKE-----GGSITMTCTAFGNPKPIVTWLKEGTLLGAS-GKY-QVSDGSLT 194
           T+ PPQ + A       G +  ++C   G     +TW+++  +L AS G+  Q++D SL 
Sbjct: 397 TDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLE 456

Query: 195 VTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEA 254
           ++ +   D G Y C A +  G    +  LLV+  P +     +   +   +  ++C A  
Sbjct: 457 ISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASG 516

Query: 255 YPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPS 314
           YP   T    W  E+   Q D   R+ +   GTLII  V PED+G Y+C  +N +G    
Sbjct: 517 YP---TPHISWSRESQALQED--SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQE 571

Query: 315 ASAYLTVQY--PARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNL 372
               +T+ Y  P  V  +  V+ V VG    + C     PP  V+ W + G    +E  L
Sbjct: 572 T---VTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVI-WYRGG----LEMIL 623

Query: 373 GWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQ 432
                  G +RI  A E   GTYTC   N LG    SA  +L +   P  T LP  +   
Sbjct: 624 APEGSSSGKLRIPAAQERDAGTYTCRAVNELG--DASAEIQLAVGHAPQLTELPR-DVTV 680

Query: 433 EAGRELLIPCAAAGDPFPVITWRK-----------VGKPSRSKHSALPSGSLQFRALSKE 481
           E GR  L+ C A G P P +TWR+            G+ SRS+     SG L F +++ E
Sbjct: 681 ELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQP--DSGVLFFESVAPE 738

Query: 482 DHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQTF 541
           D   + C A NV   + A   L V G   HAP   ++  S  T  V      +G      
Sbjct: 739 DQAPYVCEARNVFGKVQAEARLIVTG---HAP--PQIASSAPTVRV-----LEGQPVSLP 788

Query: 542 SVWMKRAQFGPHDWL--SLPVPPG-------PSWLLVDTLEPETAYQFSVLAQNKLGT 590
            + +         WL    P+PPG          L +D    E A ++S +A N  G+
Sbjct: 789 CIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGS 846



 Score =  103 bits (257), Expect = 1e-21
 Identities = 93/337 (27%), Positives = 144/337 (42%), Gaps = 20/337 (5%)

Query: 180 LGASGKYQVS-DGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENI 238
           LG    +Q S + S  +   S+ + G Y C A S  G       ++V  PP  + P  N+
Sbjct: 350 LGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNV 409

Query: 239 TVNISQDALLTCR--AEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPE 296
           TV+  + A+L+CR   EA P NLT+   W+            RV  L D +L I  + P 
Sbjct: 410 TVSPGETAVLSCRVLGEA-PYNLTWVRDWR-----VLPASTGRVAQLADLSLEISGIIPT 463

Query: 297 DSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATV 356
           D G+Y CV SN+ G +  AS +L V+   +V       +   G+   + C      P   
Sbjct: 464 DGGRYQCVASNANGVT-RASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY-PTPH 521

Query: 357 VKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVL 416
           + W+++ + LQ +  +   +   G++ I+    E  G Y+C   N +GT        L  
Sbjct: 522 ISWSRESQALQEDSRI--HVDAQGTLIIQGVAPEDAGNYSCQATNEVGT--DQETVTLYY 577

Query: 417 KDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFR 476
            DPP  + +         G E ++ C A+G P P + W + G           SG L+  
Sbjct: 578 TDPPSVSAVNA-VVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIP 636

Query: 477 ALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAP 513
           A  + D G + C A N +   +A   L V     HAP
Sbjct: 637 AAQERDAGTYTCRAVNELGDASAEIQLAV----GHAP 669



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 33/85 (38%), Positives = 40/85 (47%), Gaps = 21/85 (24%)

Query: 30   PEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPI-PIFIKFGYYPPHVDPEYAG 88
            P  VTA+AGE V L C+      G PPP +V W K   P+ PI  ++G  P         
Sbjct: 963  PLQVTAKAGEEVTLDCE----AKGSPPP-LVTWTKDSRPVPPITNRYGLLP--------- 1008

Query: 89   RASLHDKASLRLEQVRSEDQGWYEC 113
                    SLRL QV+  D G YEC
Sbjct: 1009 ------SGSLRLAQVQVGDSGHYEC 1027


>gi|224994173 roundabout 1 isoform d [Homo sapiens]
          Length = 1551

 Score =  151 bits (381), Expect = 5e-36
 Identities = 157/625 (25%), Positives = 247/625 (39%), Gaps = 81/625 (12%)

Query: 138 PPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGA------SGKYQVSDG 191
           PP   E P   I +K G   T+ C A G P P + W K G  +        S +  +  G
Sbjct: 28  PPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 192 SLTVTSV-----SREDRGAYTCRAYSIQGEAVH---TTHLLVQGPPFIVSPPENITVNIS 243
           SL    +     SR D G Y C A +  GEAV    +  + +    F  +P + + V + 
Sbjct: 87  SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD-VMVAVG 145

Query: 244 QDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTC 303
           + A++ C+        T +W  +D +     D ++ +R    G L+I   +  D+GKY C
Sbjct: 146 EPAVMECQPPRGHPEPTISWK-KDGSPLDDKDERITIR---GGKLMITYTRKSDAGKYVC 201

Query: 304 VPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDG 363
           V +N +G   S  A LTV      +  P  + V V      +C    +P  TV +W KD 
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTV-RWRKDD 260

Query: 364 RPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARL-VLKDPPYF 422
             L   +   + + +D +++I + T   +G+YTCV  N +G    SA   + V  +PP+F
Sbjct: 261 GELPKSR---YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317

Query: 423 TVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGK----------PSRSKHSALPSGS 472
            V P  +     GR +   C A G+P P I WR+ G            S S+ S   +G 
Sbjct: 318 VVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 376

Query: 473 LQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQ--VSMTTA----- 525
           L    + + D G + C   NV  SI    +L V       P  V  Q  V+ T A     
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436

Query: 526 ------------NVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLE 573
                        + W    DG    T    +K+ + G               L +   +
Sbjct: 437 VLSCVATGSPVPTILWRK--DGVLVSTQDSRIKQLENGV--------------LQIRYAK 480

Query: 574 PETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEP----LVLVTPPRCLIANRTQQG 629
                +++ +A    G + +S  + V     P+  P P    L+   P +  + + ++  
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540

Query: 630 VLLSWLPPANHSFPIDRYIME---FRVAERWELLDDGIPGTEGEFFAKDLSQDTWYEFRV 686
           V LSW P  N       YI+E         W+ + + +         K L  +  Y F V
Sbjct: 541 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAI--KGLKPNAIYLFLV 598

Query: 687 LAVMQDLISEPSNIAG-VSSTDIFP 710
            A     IS+PS I+  V + D+ P
Sbjct: 599 RAANAYGISDPSQISDPVKTQDVLP 623



 Score = 94.4 bits (233), Expect = 7e-19
 Identities = 84/311 (27%), Positives = 135/311 (43%), Gaps = 46/311 (14%)

Query: 28  EEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYA 87
           + P  +     +S   +C+      G P P  V W K    +P                 
Sbjct: 227 KRPSNLAVTVDDSAEFKCEA----RGDPVP-TVRWRKDDGELP----------------K 265

Query: 88  GRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINA-PPTFTETPP 146
            R  + D  +L++ +V + D G Y C   + +         + + + + + PP F   P 
Sbjct: 266 SRYEIRDDHTLKIRKVTAGDMGSYTC---VAENMVGKAEASATLTVQVGSEPPHFVVKPR 322

Query: 147 QYIEAKEGGSITMTCTAFGNPKPIVTWLKEGT--LL------GASGKYQVSD-GSLTVTS 197
             + A  G ++T  C A GNP+P + W +EG+  LL       +S ++ VS  G LT+T+
Sbjct: 323 DQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 381

Query: 198 VSREDRGAYTCRAYSIQGEAVHTTHLLV------QGPPFIVSPPENITVNISQDALLTCR 251
           V R D G Y C+  ++ G  +   +L V      + PP I   P N TV +    +L+C 
Sbjct: 382 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCV 441

Query: 252 AEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGR 311
           A   P     T  W+ + V        R++ L +G L I   K  D+G+YTC+ S   G 
Sbjct: 442 ATGSP---VPTILWRKDGVLVSTQ-DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 497

Query: 312 SPSASAYLTVQ 322
           + + SAY+ VQ
Sbjct: 498 A-TWSAYIEVQ 507



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 60/227 (26%), Positives = 91/227 (40%), Gaps = 20/227 (8%)

Query: 28  EEPEFVT------ARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPH 81
           E P FV          G +V  +C+     TG P P +  W + G      + F Y PP 
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEA----TGNPQPAIF-WRREGSQN---LLFSYQPP- 363

Query: 82  VDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTF 141
              + + R S+     L +  V+  D G+Y C+ L +     T        +  + PP  
Sbjct: 364 ---QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420

Query: 142 TETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGA--SGKYQVSDGSLTVTSVS 199
               P        G+  ++C A G+P P + W K+G L+    S   Q+ +G L +    
Sbjct: 421 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480

Query: 200 REDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDA 246
             D G YTC A +  GEA  + ++ VQ     V PP     N+   A
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSA 527



 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 51/194 (26%), Positives = 82/194 (42%), Gaps = 17/194 (8%)

Query: 314 SASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKN-- 371
           S S      +P R++  P  + V  G    + C  +  P  T ++W K G  ++ +K+  
Sbjct: 18  SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT-IEWYKGGERVETDKDDP 76

Query: 372 -LGWTLMEDGS---IRIEEATEEA--LGTYTCVPYNTLG-TMGQSAPARL-VLKDPPYFT 423
                L+  GS   +RI    +     G Y CV  N LG  +  +A   + +L+D   F 
Sbjct: 77  RSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD--FR 134

Query: 424 VLPGWEYRQEAGRELLIPC-AAAGDPFPVITWRKVGKP--SRSKHSALPSGSLQFRALSK 480
             P  +     G   ++ C    G P P I+W+K G P   + +   +  G L      K
Sbjct: 135 QNPS-DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRK 193

Query: 481 EDHGEWECVATNVV 494
            D G++ CV TN+V
Sbjct: 194 SDAGKYVCVGTNMV 207


>gi|224994171 roundabout 1 isoform c [Homo sapiens]
          Length = 1606

 Score =  151 bits (381), Expect = 5e-36
 Identities = 157/625 (25%), Positives = 247/625 (39%), Gaps = 81/625 (12%)

Query: 138 PPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGA------SGKYQVSDG 191
           PP   E P   I +K G   T+ C A G P P + W K G  +        S +  +  G
Sbjct: 28  PPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 192 SLTVTSV-----SREDRGAYTCRAYSIQGEAVH---TTHLLVQGPPFIVSPPENITVNIS 243
           SL    +     SR D G Y C A +  GEAV    +  + +    F  +P + + V + 
Sbjct: 87  SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD-VMVAVG 145

Query: 244 QDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTC 303
           + A++ C+        T +W  +D +     D ++ +R    G L+I   +  D+GKY C
Sbjct: 146 EPAVMECQPPRGHPEPTISWK-KDGSPLDDKDERITIR---GGKLMITYTRKSDAGKYVC 201

Query: 304 VPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDG 363
           V +N +G   S  A LTV      +  P  + V V      +C    +P  TV +W KD 
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTV-RWRKDD 260

Query: 364 RPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARL-VLKDPPYF 422
             L   +   + + +D +++I + T   +G+YTCV  N +G    SA   + V  +PP+F
Sbjct: 261 GELPKSR---YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317

Query: 423 TVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGK----------PSRSKHSALPSGS 472
            V P  +     GR +   C A G+P P I WR+ G            S S+ S   +G 
Sbjct: 318 VVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 376

Query: 473 LQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQ--VSMTTA----- 525
           L    + + D G + C   NV  SI    +L V       P  V  Q  V+ T A     
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436

Query: 526 ------------NVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLE 573
                        + W    DG    T    +K+ + G               L +   +
Sbjct: 437 VLSCVATGSPVPTILWRK--DGVLVSTQDSRIKQLENGV--------------LQIRYAK 480

Query: 574 PETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEP----LVLVTPPRCLIANRTQQG 629
                +++ +A    G + +S  + V     P+  P P    L+   P +  + + ++  
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540

Query: 630 VLLSWLPPANHSFPIDRYIME---FRVAERWELLDDGIPGTEGEFFAKDLSQDTWYEFRV 686
           V LSW P  N       YI+E         W+ + + +         K L  +  Y F V
Sbjct: 541 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAI--KGLKPNAIYLFLV 598

Query: 687 LAVMQDLISEPSNIAG-VSSTDIFP 710
            A     IS+PS I+  V + D+ P
Sbjct: 599 RAANAYGISDPSQISDPVKTQDVLP 623



 Score = 94.4 bits (233), Expect = 7e-19
 Identities = 84/311 (27%), Positives = 135/311 (43%), Gaps = 46/311 (14%)

Query: 28  EEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYA 87
           + P  +     +S   +C+      G P P  V W K    +P                 
Sbjct: 227 KRPSNLAVTVDDSAEFKCEA----RGDPVP-TVRWRKDDGELP----------------K 265

Query: 88  GRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINA-PPTFTETPP 146
            R  + D  +L++ +V + D G Y C   + +         + + + + + PP F   P 
Sbjct: 266 SRYEIRDDHTLKIRKVTAGDMGSYTC---VAENMVGKAEASATLTVQVGSEPPHFVVKPR 322

Query: 147 QYIEAKEGGSITMTCTAFGNPKPIVTWLKEGT--LL------GASGKYQVSD-GSLTVTS 197
             + A  G ++T  C A GNP+P + W +EG+  LL       +S ++ VS  G LT+T+
Sbjct: 323 DQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 381

Query: 198 VSREDRGAYTCRAYSIQGEAVHTTHLLV------QGPPFIVSPPENITVNISQDALLTCR 251
           V R D G Y C+  ++ G  +   +L V      + PP I   P N TV +    +L+C 
Sbjct: 382 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCV 441

Query: 252 AEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGR 311
           A   P     T  W+ + V        R++ L +G L I   K  D+G+YTC+ S   G 
Sbjct: 442 ATGSP---VPTILWRKDGVLVSTQ-DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 497

Query: 312 SPSASAYLTVQ 322
           + + SAY+ VQ
Sbjct: 498 A-TWSAYIEVQ 507



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 60/227 (26%), Positives = 91/227 (40%), Gaps = 20/227 (8%)

Query: 28  EEPEFVT------ARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPH 81
           E P FV          G +V  +C+     TG P P +  W + G      + F Y PP 
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEA----TGNPQPAIF-WRREGSQN---LLFSYQPP- 363

Query: 82  VDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTF 141
              + + R S+     L +  V+  D G+Y C+ L +     T        +  + PP  
Sbjct: 364 ---QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420

Query: 142 TETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGA--SGKYQVSDGSLTVTSVS 199
               P        G+  ++C A G+P P + W K+G L+    S   Q+ +G L +    
Sbjct: 421 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480

Query: 200 REDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDA 246
             D G YTC A +  GEA  + ++ VQ     V PP     N+   A
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSA 527



 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 51/194 (26%), Positives = 82/194 (42%), Gaps = 17/194 (8%)

Query: 314 SASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKN-- 371
           S S      +P R++  P  + V  G    + C  +  P  T ++W K G  ++ +K+  
Sbjct: 18  SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT-IEWYKGGERVETDKDDP 76

Query: 372 -LGWTLMEDGS---IRIEEATEEA--LGTYTCVPYNTLG-TMGQSAPARL-VLKDPPYFT 423
                L+  GS   +RI    +     G Y CV  N LG  +  +A   + +L+D   F 
Sbjct: 77  RSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD--FR 134

Query: 424 VLPGWEYRQEAGRELLIPC-AAAGDPFPVITWRKVGKP--SRSKHSALPSGSLQFRALSK 480
             P  +     G   ++ C    G P P I+W+K G P   + +   +  G L      K
Sbjct: 135 QNPS-DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRK 193

Query: 481 EDHGEWECVATNVV 494
            D G++ CV TN+V
Sbjct: 194 SDAGKYVCVGTNMV 207


>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
           sapiens]
          Length = 1562

 Score =  151 bits (381), Expect = 5e-36
 Identities = 157/625 (25%), Positives = 247/625 (39%), Gaps = 81/625 (12%)

Query: 138 PPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGA------SGKYQVSDG 191
           PP   E P   I +K G   T+ C A G P P + W K G  +        S +  +  G
Sbjct: 28  PPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 192 SLTVTSV-----SREDRGAYTCRAYSIQGEAVH---TTHLLVQGPPFIVSPPENITVNIS 243
           SL    +     SR D G Y C A +  GEAV    +  + +    F  +P + + V + 
Sbjct: 87  SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD-VMVAVG 145

Query: 244 QDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTC 303
           + A++ C+        T +W  +D +     D ++ +R    G L+I   +  D+GKY C
Sbjct: 146 EPAVMECQPPRGHPEPTISWK-KDGSPLDDKDERITIR---GGKLMITYTRKSDAGKYVC 201

Query: 304 VPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDG 363
           V +N +G   S  A LTV      +  P  + V V      +C    +P  TV +W KD 
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTV-RWRKDD 260

Query: 364 RPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARL-VLKDPPYF 422
             L   +   + + +D +++I + T   +G+YTCV  N +G    SA   + V  +PP+F
Sbjct: 261 GELPKSR---YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317

Query: 423 TVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGK----------PSRSKHSALPSGS 472
            V P  +     GR +   C A G+P P I WR+ G            S S+ S   +G 
Sbjct: 318 VVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 376

Query: 473 LQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQ--VSMTTA----- 525
           L    + + D G + C   NV  SI    +L V       P  V  Q  V+ T A     
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436

Query: 526 ------------NVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLE 573
                        + W    DG    T    +K+ + G               L +   +
Sbjct: 437 VLSCVATGSPVPTILWRK--DGVLVSTQDSRIKQLENGV--------------LQIRYAK 480

Query: 574 PETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEP----LVLVTPPRCLIANRTQQG 629
                +++ +A    G + +S  + V     P+  P P    L+   P +  + + ++  
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540

Query: 630 VLLSWLPPANHSFPIDRYIME---FRVAERWELLDDGIPGTEGEFFAKDLSQDTWYEFRV 686
           V LSW P  N       YI+E         W+ + + +         K L  +  Y F V
Sbjct: 541 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAI--KGLKPNAIYLFLV 598

Query: 687 LAVMQDLISEPSNIAG-VSSTDIFP 710
            A     IS+PS I+  V + D+ P
Sbjct: 599 RAANAYGISDPSQISDPVKTQDVLP 623



 Score = 94.4 bits (233), Expect = 7e-19
 Identities = 84/311 (27%), Positives = 135/311 (43%), Gaps = 46/311 (14%)

Query: 28  EEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYA 87
           + P  +     +S   +C+      G P P  V W K    +P                 
Sbjct: 227 KRPSNLAVTVDDSAEFKCEA----RGDPVP-TVRWRKDDGELP----------------K 265

Query: 88  GRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINA-PPTFTETPP 146
            R  + D  +L++ +V + D G Y C   + +         + + + + + PP F   P 
Sbjct: 266 SRYEIRDDHTLKIRKVTAGDMGSYTC---VAENMVGKAEASATLTVQVGSEPPHFVVKPR 322

Query: 147 QYIEAKEGGSITMTCTAFGNPKPIVTWLKEGT--LL------GASGKYQVSD-GSLTVTS 197
             + A  G ++T  C A GNP+P + W +EG+  LL       +S ++ VS  G LT+T+
Sbjct: 323 DQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 381

Query: 198 VSREDRGAYTCRAYSIQGEAVHTTHLLV------QGPPFIVSPPENITVNISQDALLTCR 251
           V R D G Y C+  ++ G  +   +L V      + PP I   P N TV +    +L+C 
Sbjct: 382 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCV 441

Query: 252 AEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGR 311
           A   P     T  W+ + V        R++ L +G L I   K  D+G+YTC+ S   G 
Sbjct: 442 ATGSP---VPTILWRKDGVLVSTQ-DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 497

Query: 312 SPSASAYLTVQ 322
           + + SAY+ VQ
Sbjct: 498 A-TWSAYIEVQ 507



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 60/227 (26%), Positives = 91/227 (40%), Gaps = 20/227 (8%)

Query: 28  EEPEFVT------ARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPH 81
           E P FV          G +V  +C+     TG P P +  W + G      + F Y PP 
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEA----TGNPQPAIF-WRREGSQN---LLFSYQPP- 363

Query: 82  VDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTF 141
              + + R S+     L +  V+  D G+Y C+ L +     T        +  + PP  
Sbjct: 364 ---QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420

Query: 142 TETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGA--SGKYQVSDGSLTVTSVS 199
               P        G+  ++C A G+P P + W K+G L+    S   Q+ +G L +    
Sbjct: 421 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480

Query: 200 REDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDA 246
             D G YTC A +  GEA  + ++ VQ     V PP     N+   A
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSA 527



 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 51/194 (26%), Positives = 82/194 (42%), Gaps = 17/194 (8%)

Query: 314 SASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKN-- 371
           S S      +P R++  P  + V  G    + C  +  P  T ++W K G  ++ +K+  
Sbjct: 18  SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT-IEWYKGGERVETDKDDP 76

Query: 372 -LGWTLMEDGS---IRIEEATEEA--LGTYTCVPYNTLG-TMGQSAPARL-VLKDPPYFT 423
                L+  GS   +RI    +     G Y CV  N LG  +  +A   + +L+D   F 
Sbjct: 77  RSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD--FR 134

Query: 424 VLPGWEYRQEAGRELLIPC-AAAGDPFPVITWRKVGKP--SRSKHSALPSGSLQFRALSK 480
             P  +     G   ++ C    G P P I+W+K G P   + +   +  G L      K
Sbjct: 135 QNPS-DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRK 193

Query: 481 EDHGEWECVATNVV 494
            D G++ CV TN+V
Sbjct: 194 SDAGKYVCVGTNMV 207


>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
           sapiens]
          Length = 1615

 Score =  151 bits (381), Expect = 5e-36
 Identities = 157/625 (25%), Positives = 247/625 (39%), Gaps = 81/625 (12%)

Query: 138 PPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGA------SGKYQVSDG 191
           PP   E P   I +K G   T+ C A G P P + W K G  +        S +  +  G
Sbjct: 28  PPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 192 SLTVTSV-----SREDRGAYTCRAYSIQGEAVH---TTHLLVQGPPFIVSPPENITVNIS 243
           SL    +     SR D G Y C A +  GEAV    +  + +    F  +P + + V + 
Sbjct: 87  SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD-VMVAVG 145

Query: 244 QDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTC 303
           + A++ C+        T +W  +D +     D ++ +R    G L+I   +  D+GKY C
Sbjct: 146 EPAVMECQPPRGHPEPTISWK-KDGSPLDDKDERITIR---GGKLMITYTRKSDAGKYVC 201

Query: 304 VPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDG 363
           V +N +G   S  A LTV      +  P  + V V      +C    +P  TV +W KD 
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTV-RWRKDD 260

Query: 364 RPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARL-VLKDPPYF 422
             L   +   + + +D +++I + T   +G+YTCV  N +G    SA   + V  +PP+F
Sbjct: 261 GELPKSR---YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317

Query: 423 TVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGK----------PSRSKHSALPSGS 472
            V P  +     GR +   C A G+P P I WR+ G            S S+ S   +G 
Sbjct: 318 VVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 376

Query: 473 LQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQ--VSMTTA----- 525
           L    + + D G + C   NV  SI    +L V       P  V  Q  V+ T A     
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436

Query: 526 ------------NVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLE 573
                        + W    DG    T    +K+ + G               L +   +
Sbjct: 437 VLSCVATGSPVPTILWRK--DGVLVSTQDSRIKQLENGV--------------LQIRYAK 480

Query: 574 PETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEP----LVLVTPPRCLIANRTQQG 629
                +++ +A    G + +S  + V     P+  P P    L+   P +  + + ++  
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540

Query: 630 VLLSWLPPANHSFPIDRYIME---FRVAERWELLDDGIPGTEGEFFAKDLSQDTWYEFRV 686
           V LSW P  N       YI+E         W+ + + +         K L  +  Y F V
Sbjct: 541 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAI--KGLKPNAIYLFLV 598

Query: 687 LAVMQDLISEPSNIAG-VSSTDIFP 710
            A     IS+PS I+  V + D+ P
Sbjct: 599 RAANAYGISDPSQISDPVKTQDVLP 623



 Score = 94.4 bits (233), Expect = 7e-19
 Identities = 84/311 (27%), Positives = 135/311 (43%), Gaps = 46/311 (14%)

Query: 28  EEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYA 87
           + P  +     +S   +C+      G P P  V W K    +P                 
Sbjct: 227 KRPSNLAVTVDDSAEFKCEA----RGDPVP-TVRWRKDDGELP----------------K 265

Query: 88  GRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINA-PPTFTETPP 146
            R  + D  +L++ +V + D G Y C   + +         + + + + + PP F   P 
Sbjct: 266 SRYEIRDDHTLKIRKVTAGDMGSYTC---VAENMVGKAEASATLTVQVGSEPPHFVVKPR 322

Query: 147 QYIEAKEGGSITMTCTAFGNPKPIVTWLKEGT--LL------GASGKYQVSD-GSLTVTS 197
             + A  G ++T  C A GNP+P + W +EG+  LL       +S ++ VS  G LT+T+
Sbjct: 323 DQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 381

Query: 198 VSREDRGAYTCRAYSIQGEAVHTTHLLV------QGPPFIVSPPENITVNISQDALLTCR 251
           V R D G Y C+  ++ G  +   +L V      + PP I   P N TV +    +L+C 
Sbjct: 382 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCV 441

Query: 252 AEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGR 311
           A   P     T  W+ + V        R++ L +G L I   K  D+G+YTC+ S   G 
Sbjct: 442 ATGSP---VPTILWRKDGVLVSTQ-DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 497

Query: 312 SPSASAYLTVQ 322
           + + SAY+ VQ
Sbjct: 498 A-TWSAYIEVQ 507



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 60/227 (26%), Positives = 91/227 (40%), Gaps = 20/227 (8%)

Query: 28  EEPEFVT------ARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPH 81
           E P FV          G +V  +C+     TG P P +  W + G      + F Y PP 
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEA----TGNPQPAIF-WRREGSQN---LLFSYQPP- 363

Query: 82  VDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTF 141
              + + R S+     L +  V+  D G+Y C+ L +     T        +  + PP  
Sbjct: 364 ---QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420

Query: 142 TETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGA--SGKYQVSDGSLTVTSVS 199
               P        G+  ++C A G+P P + W K+G L+    S   Q+ +G L +    
Sbjct: 421 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480

Query: 200 REDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDA 246
             D G YTC A +  GEA  + ++ VQ     V PP     N+   A
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSA 527



 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 51/194 (26%), Positives = 82/194 (42%), Gaps = 17/194 (8%)

Query: 314 SASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKN-- 371
           S S      +P R++  P  + V  G    + C  +  P  T ++W K G  ++ +K+  
Sbjct: 18  SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT-IEWYKGGERVETDKDDP 76

Query: 372 -LGWTLMEDGS---IRIEEATEEA--LGTYTCVPYNTLG-TMGQSAPARL-VLKDPPYFT 423
                L+  GS   +RI    +     G Y CV  N LG  +  +A   + +L+D   F 
Sbjct: 77  RSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD--FR 134

Query: 424 VLPGWEYRQEAGRELLIPC-AAAGDPFPVITWRKVGKP--SRSKHSALPSGSLQFRALSK 480
             P  +     G   ++ C    G P P I+W+K G P   + +   +  G L      K
Sbjct: 135 QNPS-DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRK 193

Query: 481 EDHGEWECVATNVV 494
            D G++ CV TN+V
Sbjct: 194 SDAGKYVCVGTNMV 207


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  150 bits (379), Expect = 8e-36
 Identities = 139/507 (27%), Positives = 206/507 (40%), Gaps = 50/507 (9%)

Query: 18   LAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGY 77
            L  + +  ++  P  V A A E V+L C+     +G P P  + W K G+ +   +    
Sbjct: 2751 LTVQASPVVKPLPSVVRAVAEEEVLLPCEA----SGIPRP-TITWQKEGLNVATGVSTQV 2805

Query: 78   YPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINA 137
             P                  LR+     ED G Y C       +           L +  
Sbjct: 2806 LPG---------------GQLRIAHASPEDAGNYLCIA-----KNSAGSAMGKTRLVVQV 2845

Query: 138  PPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGT-LLGASGKYQVS-DGSLTV 195
            PP      P  +   EG    + C A G+P+P +TW K+G  + GA GK+ +   G L V
Sbjct: 2846 PPVIENGLPD-LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLV 2904

Query: 196  TSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAY 255
             ++  +D G YTC A +  G A    HL +   P   + P + ++ +     L C A   
Sbjct: 2905 KNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGS 2964

Query: 256  PGNLTYTWYWQD----ENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGR 311
            P      W   D    E V  Q+            TL    V  EDSG Y C   N +GR
Sbjct: 2965 P-TPRIGWTVNDRPVTEGVSEQDG---------GSTLQRAAVSREDSGTYVCWAENRVGR 3014

Query: 312  SPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKN 371
            + + S     + P         +  PVG    + C V  + P   + W KDG PL+   +
Sbjct: 3015 TQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD-PVPDIHWIKDGLPLR-GSH 3072

Query: 372  LGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYR 431
            L   L ++GS+ I     +  G Y C+  N +G         LVL+  P F V P  +  
Sbjct: 3073 LRHQL-QNGSLTIHRTERDDAGRYQCLAENEMGV--AKKVVILVLQSAPVFQVEP-QDMT 3128

Query: 432  QEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKH--SALPSGSLQFRALSKEDHGEWECV 489
              +G ++ + C A G+P P I W + G+P R+      LP GSL    +   D G ++CV
Sbjct: 3129 VRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCV 3188

Query: 490  ATNVVTSITASTHLTVIGTSPHAPGSV 516
            A N++ S TA   L V G    + GS+
Sbjct: 3189 AHNLLGSATARAFLVVRGEPQGSWGSM 3215



 Score =  148 bits (374), Expect = 3e-35
 Identities = 156/589 (26%), Positives = 238/589 (40%), Gaps = 48/589 (8%)

Query: 30   PEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGR 89
            P FV   A   +VL C V      +P P +  W + G+ +           H      GR
Sbjct: 2397 PRFVVGLAPGQLVLECSV----EAEPAPKIT-WHRDGIVLQ-------EDAHTQFPERGR 2444

Query: 90   ASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYI 149
                    L+L+ + + D G Y C       +           + I+  PT    PP  +
Sbjct: 2445 F-------LQLQALSTADSGDYSCTA-----RNAAGSTSVAFRVEIHTVPTIRSGPPA-V 2491

Query: 150  EAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGA-SGKYQV-SDGSLTVTSVSREDRGAYT 207
                  +  + C A G P P+V+W K+   L   S ++++  +GSL +  V  +D G Y 
Sbjct: 2492 NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL 2551

Query: 208  CRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQD 267
            C A +  G       L V  PP I   P N+T+     ALL C A   P  L    +W+D
Sbjct: 2552 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVV--WWKD 2609

Query: 268  ENVYFQNDLKLR---VRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
                 + D +L+    R+L    L++    P+DS ++ CV SN +G +      +TV  P
Sbjct: 2610 GQ---KLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEA-HRLYQVTVHVP 2665

Query: 325  ARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRI 384
              + +      V +     + C      PA  V W+K G  L   +  G+ +   G++ I
Sbjct: 2666 PTIADDQTDFTVTMMAPVVLTCH-STGIPAPTVSWSKAGAQLGA-RGSGYRVSPSGALEI 2723

Query: 385  EEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAA 444
             +A     G YTC   N+ G   +     L ++  P    LP    R  A  E+L+PC A
Sbjct: 2724 GQALPIHAGRYTCSARNSAGVAHKH--VFLTVQASPVVKPLPS-VVRAVAEEEVLLPCEA 2780

Query: 445  AGDPFPVITWRKVGKPSRSKHS--ALPSGSLQFRALSKEDHGEWECVATNVVTSITASTH 502
            +G P P ITW+K G    +  S   LP G L+    S ED G + C+A N   S    T 
Sbjct: 2781 SGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTR 2840

Query: 503  LTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPP 562
            L V    P    +    +S T  + ++ P    G  +    W K  Q          + P
Sbjct: 2841 LVV--QVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQP 2898

Query: 563  GPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEP 611
                LLV  LE + A  ++  A+N +G +     +T+  L  P+ T  P
Sbjct: 2899 SGE-LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI--LVLPVFTTLP 2944



 Score =  138 bits (347), Expect = 4e-32
 Identities = 122/412 (29%), Positives = 174/412 (42%), Gaps = 35/412 (8%)

Query: 98   LRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVH--LTINAPPTF---TETPPQYIEAK 152
            L++  VR+E+ G Y CK               W+H  L +  PP     TE   + +   
Sbjct: 1615 LQIPLVRAENAGRYSCKA-------SNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVN 1667

Query: 153  EGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQV-SDGS-LTVTSVSREDRGAYTCRA 210
               ++++ C A GNP P ++WL+ G     S + QV  DG  L V++    D  +Y C A
Sbjct: 1668 ASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVA 1727

Query: 211  YSIQGEAVHTTHLLVQGPPFIVS-PPENITVNISQDALLTCRAEAYPGNLTYTWYWQDEN 269
             +  G A     L VQ PP I     E +T  ++    L C   A+P N   TWY   + 
Sbjct: 1728 ENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHP-NPEVTWYKDSQA 1786

Query: 270  VYFQNDLKLRVRILIDG--TLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARV 327
            +    ++      L+ G  TL + R +  DSG YTC   N+ GR       L+V  P   
Sbjct: 1787 LSLGEEV-----FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL-VQLSVLVPPAF 1840

Query: 328  LNMP----PVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIR 383
               P      + V VG    + C  DA P  TV  W KDG+PL + +     L     + 
Sbjct: 1841 RQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVT-WYKDGQPLVLAQRT-QALRGGQRLE 1898

Query: 384  IEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCA 443
            I+EA     G Y+C   N  G   ++    L ++ PP F         Q AG  L++ C 
Sbjct: 1899 IQEAQVSDKGLYSCKVSNVAGEAVRT--FTLTVQVPPTFENPKTETVSQVAGSPLVLTCD 1956

Query: 444  AAGDPFPVITWRKVGKP--SRSKHSALP-SGSLQFRALSKEDHGEWECVATN 492
             +G P P +TW K   P  S + H  +   G LQ   L     G + CVA N
Sbjct: 1957 VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN 2008



 Score =  136 bits (343), Expect = 1e-31
 Identities = 138/511 (27%), Positives = 208/511 (40%), Gaps = 69/511 (13%)

Query: 27   REEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEY 86
            R   + V  R G+  VL C+     T   P   V W+K G P+ +  +            
Sbjct: 1845 RGPQDAVLVRVGDKAVLSCE-----TDALPEPTVTWYKDGQPLVLAQR------------ 1887

Query: 87   AGRASLHDKASLRLEQVRSEDQGWYECKVL-MLDQQYDTFHNGSWVHLTINAPPTFTETP 145
                +L     L +++ +  D+G Y CKV  +  +   TF       LT+  PPTF    
Sbjct: 1888 --TQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFT------LTVQVPPTFENPK 1939

Query: 146  PQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQV--SDGSLTVTSVSREDR 203
             + +    G  + +TC   G P P VTWLK+   + +S  + V    G L ++ +     
Sbjct: 1940 TETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQA 1999

Query: 204  GAYTCRAYSIQGEAVHTTHLLVQGPPFIVSP--PENITVNISQDALLTCRAEAYPGNLTY 261
            G YTC A + Q EA     + V   P I S        V   Q+  L C A+  P     
Sbjct: 2000 GTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQP---PP 2056

Query: 262  TWYWQDENVYFQNDLKLRVRILID-GTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLT 320
               W  +      D+   +R  +D G+L++  ++  D+G YTCV  N  G          
Sbjct: 2057 DVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARL----- 2111

Query: 321  VQYPARVLNMPPVIYVPVGIHGYI----------RCPVDAEPPATVVKWNKDGRPLQVEK 370
              +   VL +PP I       G +           CPV   PP   V W KDG PL + +
Sbjct: 2112 --HTVNVL-VPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIH-VSWLKDGLPLPLSQ 2167

Query: 371  NLGWTLMEDG--SIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGW 428
                TL+     ++RI +      G +TCV  +  G   ++    L ++ PP   VL   
Sbjct: 2168 R---TLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRN--FTLQVQVPP---VLEPV 2219

Query: 429  EYRQEA----GRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSKEDHG 484
            E++ +     G  + +PC A G P P+++W K G+P  S+ S     SLQ  A+   D G
Sbjct: 2220 EFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQ-SLEQGPSLQLEAVGAGDSG 2278

Query: 485  EWECVATNVVTSITASTHLTVIGTSPHAPGS 515
             + CVA +          LTV+   PH   S
Sbjct: 2279 TYSCVAVSEAGEARRHFQLTVM-EPPHIEDS 2308



 Score =  134 bits (338), Expect = 5e-31
 Identities = 156/612 (25%), Positives = 252/612 (41%), Gaps = 88/612 (14%)

Query: 33   VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
            + +R GE V + C    PV G PP +V  W K G+P+P+               + R  L
Sbjct: 2132 LVSRPGELVTMVC----PVRGSPPIHV-SWLKDGLPLPL---------------SQRTLL 2171

Query: 93   HDKA-SLRLEQVRSEDQGWYECKVL----MLDQQYDTFHNGSWVHLTINAPPTFTETPPQ 147
            H    +LR+ +V+  D G + C       + D+ +          L +  PP       Q
Sbjct: 2172 HGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFT---------LQVQVPPVLEPVEFQ 2222

Query: 148  Y-IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSREDRGAY 206
              +    G  + + C A G P P+V+W+K+G  L +    Q    SL + +V   D G Y
Sbjct: 2223 NDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQ--GPSLQLEAVGAGDSGTY 2280

Query: 207  TCRAYSIQGEAVHTTHLLVQGPPFI--VSPPENITVNISQDALLTCRAEAYPGNLTYTWY 264
            +C A S  GEA     L V  PP I     P  +++       L C A+  P     TW+
Sbjct: 2281 SCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTP-QPNITWH 2339

Query: 265  WQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
               + +    +     R+L          +  D+G YTC+  +  G +   S  + VQ P
Sbjct: 2340 KDGQALTRLENNSRATRVL----------RVRDAGLYTCLAESPAG-AIEKSFRVRVQAP 2388

Query: 325  ARVLNMPPVIYVPVGI---HGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGS 381
              ++      +V VG+      + C V+AE PA  + W++DG  LQ + +  +   E G 
Sbjct: 2389 PNIVGPRGPRFV-VGLAPGQLVLECSVEAE-PAPKITWHRDGIVLQEDAHTQFP--ERGR 2444

Query: 382  -IRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLI 440
             ++++  +    G Y+C   N  G+   S   R+ +   P     P         +  L+
Sbjct: 2445 FLQLQALSTADSGDYSCTARNAAGS--TSVAFRVEIHTVPTIRSGPP-AVNVSVNQTALL 2501

Query: 441  PCAAAGDPFPVITWRKVG---KPSRSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSI 497
            PC A G P P+++WRK      P   +   LP GSL+ + +  +D G + C+A+N   S 
Sbjct: 2502 PCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSD 2561

Query: 498  TASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMK-------RAQF 550
                 L V+     AP      +++T    +  P    G  +   VW K       R Q 
Sbjct: 2562 RQGRDLRVLEPPAIAPSP--SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQ 2619

Query: 551  GPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVN---TLA---- 603
            G +  L        + LL+    P+ + QF  +  N++G +     VTV+   T+A    
Sbjct: 2620 GAYRLLP------SNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQT 2673

Query: 604  -FPITTPEPLVL 614
             F +T   P+VL
Sbjct: 2674 DFTVTMMAPVVL 2685



 Score =  119 bits (299), Expect = 2e-26
 Identities = 152/603 (25%), Positives = 239/603 (39%), Gaps = 83/603 (13%)

Query: 33   VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
            +TA     + L C+ +    G PPP  + WF+   P+          P  D        +
Sbjct: 1171 ITAALHSPLTLLCEAM----GIPPP-AIRWFRGEEPVS---------PGEDTYLLAGGWM 1216

Query: 93   HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTF-TETPPQYIEA 151
                 L++ Q + +D G Y C  L  ++  +   N S   + +  PP+   E   + I+ 
Sbjct: 1217 -----LKMTQTQEQDSGLYSC--LASNEAGEARRNFS---VEVLVPPSIENEDLEEVIKV 1266

Query: 152  KEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVS-DG-SLTVTSVSREDRGAYTCR 209
             +G +  + C   G+P+P +TW K+G  L     + +S DG  L V   +    G Y+C 
Sbjct: 1267 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 1326

Query: 210  AYSIQGEAVHTTHLLVQGPPFIV-----SPPENITVNISQDALLTCRAEAYPG-NLTYTW 263
            A +  GE      L V   P I+     S  E +TV ++    L C A A+P  N+T   
Sbjct: 1327 AANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNIT--- 1383

Query: 264  YWQDENVYFQNDLKLRVRILIDGT--LIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTV 321
             W  +   F+    ++   L+ GT  L I   + ED+G+YTCV +N LG +   + ++ V
Sbjct: 1384 -WMKDGAPFEASRNIQ---LLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVK-NYHVEV 1438

Query: 322  QYPARVLNMPPV-------IYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGW 374
              P  +    P+       +   V     + C   A PP T ++W KDG+P+     L  
Sbjct: 1439 LIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPT-IRWYKDGQPVTPSSRL-Q 1496

Query: 375  TLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGW------ 428
             L E   ++I+       G Y CV  N  G   Q     ++++ PP F  +  +      
Sbjct: 1497 VLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD--FNVLIQVPPMFQKVGDFSAAFEI 1554

Query: 429  ------------EYRQ-EAGRELLIPCAAAGDPFPVITWRKVGKP--SRSKHSALPSGS- 472
                        EYR+        + C     P P +TW +  +P  +  + S L  G  
Sbjct: 1555 LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRV 1614

Query: 473  LQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTAN----VS 528
            LQ   +  E+ G + C A+N V        L V+ T P   G     V   T N    VS
Sbjct: 1615 LQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL-TPPVILGDTEELVEEVTVNASSTVS 1673

Query: 529  WEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKL 588
             +    G    T S       F P     L V      L V T E   A  +  +A+N+ 
Sbjct: 1674 LQCPALGNPVPTISWLQNGLPFSPSP--RLQVLEDGQVLQVSTAEVADAASYMCVAENQA 1731

Query: 589  GTS 591
            G++
Sbjct: 1732 GSA 1734



 Score =  119 bits (298), Expect = 2e-26
 Identities = 140/576 (24%), Positives = 238/576 (41%), Gaps = 55/576 (9%)

Query: 33   VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
            V+  A ESV L C      +   PP V+ W+K G P+             +P      S 
Sbjct: 889  VSVVANESVALECQ-----SHAMPPPVLSWWKDGRPL-------------EPRPGVHLSA 930

Query: 93   HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAK 152
             DKA L++++    D G Y C+ L    + +  +N     L +   P F       +  +
Sbjct: 931  -DKALLQVDRADVWDAGHYTCEALNQAGRSEKHYN-----LNVWVAPVFPLRESHTLTVR 984

Query: 153  EGGSITMTCTAFGNPKPIVTWLKEGTLL---GASGKYQVSDGSLTVTSVSR-EDRGAYTC 208
            EG   +++C   G P P ++W K+G  L   GA  ++  + G L     ++    G YTC
Sbjct: 985  EGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTC 1044

Query: 209  RAYSIQGEAVHTTHLLVQGPPFIVSPPENIT-VNISQD--ALLTCRAEAYPGNLTYTWYW 265
               ++ G +     L V  PP I  P E  T V++ QD  A L C A   P   T TW  
Sbjct: 1045 ECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP-TVTWER 1103

Query: 266  QDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPA 325
              + V  +  L+L+ +     +L + R +   +G+Y+CV  N  GR+        +  P 
Sbjct: 1104 DGQPVGAELGLQLQNQ---GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPE 1160

Query: 326  RVLNMPPVIYVPVGIHGYIRCPVDA---EPPATVVKWNKDGRPLQVEKNLGWTLMEDGSI 382
             + ++ P+  +   +H  +    +A    PPA  ++W +   P+   ++  + L     +
Sbjct: 1161 LIGDLDPLTNITAALHSPLTLLCEAMGIPPPA--IRWFRGEEPVSPGEDT-YLLAGGWML 1217

Query: 383  RIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWE-YRQEAGRELLIP 441
            ++ +  E+  G Y+C+  N  G   ++    +++  PP        E  +   G+   + 
Sbjct: 1218 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLDGQTAHLM 1275

Query: 442  CAAAGDPFPVITWRKVGKP--SRSKHSALPSG-SLQFRALSKEDHGEWECVATNVVTSIT 498
            C   G P P +TW K G+P      H   P G  LQ    +    G + C+A N V   T
Sbjct: 1276 CNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKT 1335

Query: 499  ASTHLTVIGTSP----HAPGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFGPHD 554
                L+V+  +P     A  S   +V++T  N          +      WMK     P +
Sbjct: 1336 KHFQLSVL-LAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDG--APFE 1392

Query: 555  -WLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLG 589
               ++ + PG   L +   + E A Q++ +  N+LG
Sbjct: 1393 ASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1428



 Score =  119 bits (298), Expect = 2e-26
 Identities = 126/479 (26%), Positives = 192/479 (40%), Gaps = 52/479 (10%)

Query: 31   EFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRA 90
            E VTA    SV L CDV       P P V  W+K    + +  +    P           
Sbjct: 1754 EQVTAILNSSVSLPCDV----HAHPNPEVT-WYKDSQALSLGEEVFLLP----------- 1797

Query: 91   SLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETP--PQ- 147
                  +L+L + R  D G Y C+ L          +   V L++  PP F + P  PQ 
Sbjct: 1798 ---GTHTLQLGRARLSDSGMYTCEALNA-----AGRDQKLVQLSVLVPPAFRQAPRGPQD 1849

Query: 148  YIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGS--LTVTSVSREDRGA 205
             +  + G    ++C     P+P VTW K+G  L  + + Q   G   L +      D+G 
Sbjct: 1850 AVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGL 1909

Query: 206  YTCRAYSIQGEAVHTTHLLVQGPPFIVSP-PENITVNISQDALLTCRAEAYPGNLTYTWY 264
            Y+C+  ++ GEAV T  L VQ PP   +P  E ++       +LTC     P   T TW 
Sbjct: 1910 YSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAP-TVTWL 1968

Query: 265  WQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
                 V       +   +   G L + R++P  +G YTCV  N+   +        +  P
Sbjct: 1969 KDRMPV---ESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAP 2025

Query: 325  -ARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTL---MEDG 380
              R   +    +V  G    + C  D +PP  V  W KDG PL   +++G  L   ++ G
Sbjct: 2026 RIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVA-WLKDGSPL--GQDMGPHLRFYLDGG 2082

Query: 381  SIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWE----YRQEAGR 436
            S+ ++       G YTCV +N  G   +     +++  PP  T+  G +         G 
Sbjct: 2083 SLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV--PP--TIKQGADGSGTLVSRPGE 2138

Query: 437  ELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGS---LQFRALSKEDHGEWECVATN 492
             + + C   G P   ++W K G P       L  GS   L+   +   D G + CVA +
Sbjct: 2139 LVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAAS 2197



 Score =  118 bits (295), Expect = 4e-26
 Identities = 130/497 (26%), Positives = 187/497 (37%), Gaps = 44/497 (8%)

Query: 40   SVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLR 99
            SV L C      +G PPP V  WFK   P+                + G     D   LR
Sbjct: 711  SVTLEC----LASGVPPPDV-SWFKGHQPVS--------------SWMGVTVSVDGRVLR 751

Query: 100  LEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITM 159
            +EQ +  D G Y C    +    +  +      L +N PP  T  P           + +
Sbjct: 752  IEQAQLSDAGSYRCVASNVAGSTELRYG-----LRVNVPPRITLPPSLPGPVLVNTPVRL 806

Query: 160  TCTAFGNPKPIVTWLKEGTLLGASGK--YQVSDGS--LTVTSVSREDRGAYTCRAYSIQG 215
            TC A G P P + WLK+G  +  +G    QV  G   LT+ S    D G Y+C A S  G
Sbjct: 807  TCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG 866

Query: 216  EAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQND 275
            E      L V  PP I+    N++V  ++   L C++ A P  +  +W W+D       +
Sbjct: 867  EDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSW-WKDGRPL---E 921

Query: 276  LKLRVRILIDGTLI-IFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVI 334
             +  V +  D  L+ + R    D+G YTC   N  GRS           P   L     +
Sbjct: 922  PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTL 981

Query: 335  YVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVE-KNLGWTLMEDGSIRIEEATEEALG 393
             V  G    + C      P   + W KDG+PL  E   L         + + +A     G
Sbjct: 982  TVREGHPTSLSCECRG-VPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEG 1040

Query: 394  TYTCVPYNTLGTMGQSAPARLVLKDPPYFT--VLPGWEYRQEAGRELLIPCAAAGDPFPV 451
            TYTC   N +G   Q    +L +  PP       P  +          + C A G P P 
Sbjct: 1041 TYTCECSNVVGNSSQD--LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT 1098

Query: 452  ITWRKVGKPSRSK---HSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGT 508
            +TW + G+P  ++          SL          G + CVA N+         L+V+  
Sbjct: 1099 VTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL-V 1157

Query: 509  SPHAPGSVRVQVSMTTA 525
             P   G +    ++T A
Sbjct: 1158 PPELIGDLDPLTNITAA 1174



 Score =  116 bits (290), Expect = 2e-25
 Identities = 163/647 (25%), Positives = 240/647 (37%), Gaps = 80/647 (12%)

Query: 33  VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
           V   AG  V L+C      +G P P V EW K   P+   +  G   PH+  +  G+   
Sbjct: 227 VLGLAGADVELQCWT----SGVPTPQV-EWTKDRQPV---LPGG---PHLQVQEDGQV-- 273

Query: 93  HDKASLRLEQVRSEDQGWYECKVLM-LDQQYDTFHNGSWVHLTINAPPT-FTETPPQYIE 150
                LR+      D+G Y+C       QQ   F       L ++APPT +       + 
Sbjct: 274 -----LRITGSHVGDEGRYQCVAFSPAGQQARDFQ------LRVHAPPTIWGSNETGEVA 322

Query: 151 AKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGS--LTVTSVSREDRGAYTC 208
             E   + + C A G P P +TW K+G LL  S K   + G   L +      D G YTC
Sbjct: 323 VMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTC 382

Query: 209 RAYSIQGEAVHTTHLLVQGPPFIVSP---PENITVNISQDALLTCRAEAYPGNLTYTWYW 265
           +A +  G A   T L V  PP I      P  +     +   L C A  +P   T +W+ 
Sbjct: 383 KASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP-TLSWHH 441

Query: 266 QDENVYFQNDLKLRVRILIDGTLIIFRVKPE-DSGKYTCVPSNSLGRSPSASAYLTVQYP 324
           +   V   N+ +L      DG+++      E  SG Y+CV S     SP+  A L  QY 
Sbjct: 442 EGLPVAESNESRLET----DGSVLRLESPGEASSGLYSCVAS-----SPAGEAVL--QYS 490

Query: 325 ARVLNMPPVIYVPVGIHGY-------IRCPVDAE-PPATVVKWNKDGRPLQVEKNLGWTL 376
             V  +PP + V  G+          +  P  A   P   ++W ++GRP   E+  G  +
Sbjct: 491 VEV-QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP--AEELAGVQV 547

Query: 377 MEDGS-IRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAG 435
              G+ + I+    +  G + C   N  GT G      +  +  P    +P  +Y     
Sbjct: 548 ASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXE 607

Query: 436 RELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSG----------------SLQFRALS 479
                P  AA DP     W    KP   +    P                   LQ   + 
Sbjct: 608 HHSSFP--AACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVD 665

Query: 480 KEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQ 539
             D G + C ATN+         L V+      PG V   V +  A+V+ E    G    
Sbjct: 666 LRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAV-LENASVTLECLASGVPPP 724

Query: 540 TFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTV 599
             S W K  Q     W+ + V      L ++  +   A  +  +A N  G++     + V
Sbjct: 725 DVS-WFKGHQ-PVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRV 782

Query: 600 NT---LAFPITTPEPLVLVTPPRCLIANRTQQGVLLSWLPPANHSFP 643
           N    +  P + P P+++ TP R            L WL   N   P
Sbjct: 783 NVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSP 829



 Score =  107 bits (266), Expect = 1e-22
 Identities = 130/512 (25%), Positives = 199/512 (38%), Gaps = 42/512 (8%)

Query: 33  VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVD-PEYAGRAS 91
           V+  AG+S+ L CD      G P P +V W K    + + + +  Y   +   +  G   
Sbjct: 106 VSGMAGQSLTLECDA----NGFPVPEIV-WLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 160

Query: 92  LHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPP----- 146
           L +  SL   +++    G    +     Q    +  G         P  F+   P     
Sbjct: 161 LDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLG 220

Query: 147 ----QYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKY-QVSDGS--LTVTSVS 199
               Q +    G  + + C   G P P V W K+   +   G + QV +    L +T   
Sbjct: 221 AGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSH 280

Query: 200 REDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDAL--LTCRAEAYP- 256
             D G Y C A+S  G+      L V  PP I    E   V + +D L  L C A   P 
Sbjct: 281 VGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPT 340

Query: 257 GNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSAS 316
            N+T    W  +        K+ V       L + R +  D+G YTC  SN++G +  A+
Sbjct: 341 PNIT----WFKDGALLPTSTKV-VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKAT 395

Query: 317 AYLTVQYPARVL---NMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLG 373
             L V  P  +      P V+    G    + C     P  T + W+ +G P+  E N  
Sbjct: 396 R-LDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPT-LSWHHEGLPV-AESNES 452

Query: 374 WTLMEDGSI-RIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPG-WEYR 431
             L  DGS+ R+E   E + G Y+CV  +  G         + +  PP   V  G  +  
Sbjct: 453 -RLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV--PPQLLVAEGLGQVT 509

Query: 432 QEAGRELLIPCAAAGDPFPVITWRKVGKPSR---SKHSALPSGSLQFRALSKEDHGEWEC 488
              G+ L +PC A+G P P I W + G+P+        A    +L    +  +  G + C
Sbjct: 510 TIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFAC 569

Query: 489 VATNVVTSITASTHLTVIGTSPHAPGSVRVQV 520
            ATN   +  A   ++V G    APG + V +
Sbjct: 570 QATNEAGTAGAEVEVSVHG--EWAPGVLEVPI 599



 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 113/478 (23%), Positives = 182/478 (38%), Gaps = 49/478 (10%)

Query: 33  VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
           VT   G+ + L C      +G P P  ++W + G P                E AG    
Sbjct: 508 VTTIVGQPLELPCQA----SGSPVP-TIQWLQNGRPAE--------------ELAGVQVA 548

Query: 93  HDKASLRLEQVRSEDQGWYECKVL----MLDQQYDTFHNGSWVHLTINAPPTFTETPPQY 148
               +L ++ V  +  G + C+          + +   +G W    +  P        ++
Sbjct: 549 SQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEH 608

Query: 149 IEAKEGGSITMTCTAFG-NPKP--IVTWLKEGTLLGASGKYQVSDG---SLTVTSVSRED 202
             +            +G +PKP  +  W   G+L G      V+      L +  V   D
Sbjct: 609 HSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRD 668

Query: 203 RGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYT 262
            G YTC A ++ GE+     L V  PP I   P N  V  +    L C A   P     +
Sbjct: 669 EGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPP-DVS 727

Query: 263 WYWQDENVYFQNDLKLRVRILIDGTLI-IFRVKPEDSGKYTCVPSNSLGRSPSASAYLTV 321
           W+   + V       + V + +DG ++ I + +  D+G Y CV SN  G S      L V
Sbjct: 728 WFKGHQPV----SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG-STELRYGLRV 782

Query: 322 QYPARVLNMPPVIYVPVGIHGYIRCPVDAE-PPATVVKWNKDGRPLQVEKNLGWTLMEDG 380
             P R+  +PP +  PV ++  +R   +A   P+  + W KDG P+      G  +   G
Sbjct: 783 NVPPRI-TLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGG 841

Query: 381 SI-RIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQE--AGRE 437
            +  +  A     G Y+CV  + +G   Q    ++ +  PP    + G E      A   
Sbjct: 842 RVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHM--PP---SILGEELNVSVVANES 896

Query: 438 LLIPCAAAGDPFPVITWRKVGKPSRSK---HSALPSGSLQFRALSKEDHGEWECVATN 492
           + + C +   P PV++W K G+P   +   H +     LQ       D G + C A N
Sbjct: 897 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALN 954



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 109/409 (26%), Positives = 156/409 (38%), Gaps = 66/409 (16%)

Query: 149 IEAKEGGSITMT-------CTAFGNPKPIVTWLKEGT---LLGASGKYQVSDGSLTVTSV 198
           +E K  G + +T       C   G PKP VTW K  +   L G  G   + +GSL + SV
Sbjct: 5   LEIKGLGDVALTVGLEAGGCGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASV 64

Query: 199 SREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSP--PENITVNISQDALLTCRAEAYP 256
           S  D G Y C+A +  G       L+V  PP I       N++    Q   L C A  +P
Sbjct: 65  SPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFP 124

Query: 257 -----------------GNLTYTW--YWQDENVYFQNDLKLRVRILIDGTLIIF-RVKPE 296
                            G   Y W   W     +         R+L +G  + F R++P 
Sbjct: 125 VPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGH---------RLLDEGQSLHFPRIQPG 175

Query: 297 DSGKYTCVPSNSLGRSPSASAYLT--VQYPARVLNMPPVIYVPVG------IHGYIRCPV 348
            SG+       S        A L    Q+P      PP     +G      + G     V
Sbjct: 176 RSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADV 235

Query: 349 DAE-----PPATVVKWNKDGRPLQVEKNLGWTLMEDGSI-RIEEATEEALGTYTCVPYNT 402
           + +      P   V+W KD +P+ +       + EDG + RI  +     G Y CV ++ 
Sbjct: 236 ELQCWTSGVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP 294

Query: 403 LGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRE---LLIPCAAAGDPFPVITWRKVGK 459
            G   Q+   +L +  PP  T+    E  + A  E   + + C A G P P ITW K G 
Sbjct: 295 AGQ--QARDFQLRVHAPP--TIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGA 350

Query: 460 --PSRSKHSALPSG-SLQFRALSKEDHGEWECVATNVVTSITASTHLTV 505
             P+ +K      G  LQ       D G + C A+N V +   +T L V
Sbjct: 351 LLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 399



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 41/120 (34%), Positives = 52/120 (43%), Gaps = 20/120 (16%)

Query: 442 CAAAGDPFPVITWRKVGKPSRSKH-----SALPSGSLQFRALSKEDHGEWECVATNVVTS 496
           C   G P P +TWRK G  S   H     + L  GSL   ++S  D G++EC ATN V S
Sbjct: 24  CGTHGTPKPQVTWRK-GPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 82

Query: 497 ITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYD-------GGYEQTFSVWMKRAQ 549
            +    L V     + P S+R       ANVS   G          G+     VW+K AQ
Sbjct: 83  TSRRAKLVV-----YVPPSIR--EDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQ 135



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 26/89 (29%), Positives = 39/89 (43%), Gaps = 6/89 (6%)

Query: 94  DKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQY-IEAK 152
           ++ SL L  V   D G YEC+        +         L +  PP+  E   +  +   
Sbjct: 55  EEGSLFLASVSPADSGDYECQATN-----EVGSTSRRAKLVVYVPPSIREDGRKANVSGM 109

Query: 153 EGGSITMTCTAFGNPKPIVTWLKEGTLLG 181
            G S+T+ C A G P P + WLK+  L+G
Sbjct: 110 AGQSLTLECDANGFPVPEIVWLKDAQLVG 138


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  150 bits (379), Expect = 8e-36
 Identities = 139/507 (27%), Positives = 206/507 (40%), Gaps = 50/507 (9%)

Query: 18   LAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGY 77
            L  + +  ++  P  V A A E V+L C+     +G P P  + W K G+ +   +    
Sbjct: 3942 LTVQASPVVKPLPSVVRAVAEEEVLLPCEA----SGIPRP-TITWQKEGLNVATGVSTQV 3996

Query: 78   YPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINA 137
             P                  LR+     ED G Y C       +           L +  
Sbjct: 3997 LPG---------------GQLRIAHASPEDAGNYLCIA-----KNSAGSAMGKTRLVVQV 4036

Query: 138  PPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGT-LLGASGKYQVS-DGSLTV 195
            PP      P  +   EG    + C A G+P+P +TW K+G  + GA GK+ +   G L V
Sbjct: 4037 PPVIENGLPD-LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLV 4095

Query: 196  TSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAY 255
             ++  +D G YTC A +  G A    HL +   P   + P + ++ +     L C A   
Sbjct: 4096 KNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGS 4155

Query: 256  PGNLTYTWYWQD----ENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGR 311
            P      W   D    E V  Q+            TL    V  EDSG Y C   N +GR
Sbjct: 4156 P-TPRIGWTVNDRPVTEGVSEQDG---------GSTLQRAAVSREDSGTYVCWAENRVGR 4205

Query: 312  SPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKN 371
            + + S     + P         +  PVG    + C V  + P   + W KDG PL+   +
Sbjct: 4206 TQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD-PVPDIHWIKDGLPLR-GSH 4263

Query: 372  LGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYR 431
            L   L ++GS+ I     +  G Y C+  N +G         LVL+  P F V P  +  
Sbjct: 4264 LRHQL-QNGSLTIHRTERDDAGRYQCLAENEMGV--AKKVVILVLQSAPVFQVEP-QDMT 4319

Query: 432  QEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKH--SALPSGSLQFRALSKEDHGEWECV 489
              +G ++ + C A G+P P I W + G+P R+      LP GSL    +   D G ++CV
Sbjct: 4320 VRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCV 4379

Query: 490  ATNVVTSITASTHLTVIGTSPHAPGSV 516
            A N++ S TA   L V G    + GS+
Sbjct: 4380 AHNLLGSATARAFLVVRGEPQGSWGSM 4406



 Score =  148 bits (374), Expect = 3e-35
 Identities = 134/463 (28%), Positives = 188/463 (40%), Gaps = 38/463 (8%)

Query: 63   FKFGVPIPIFIKFGYYP-PHVDPEYAGRASLHD-------KASLRLEQVRSEDQGWYECK 114
            F  GV + +      YP PH+      +A   D       + +L ++ V  ED G Y C+
Sbjct: 619  FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQ 678

Query: 115  VLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWL 174
                    +   +   V L    PP+ +      + A  G    + C A G P P V W 
Sbjct: 679  ATN-----EVGTDQETVTLYYTDPPSVSAVNAVVLVAV-GEEAVLVCEASGVPPPRVIWY 732

Query: 175  KEGT--LLGASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIV 232
            + G   +L   G    S G L + +    D G YTCRA +  G+A     L V   P + 
Sbjct: 733  RGGLEMILAPEGS---SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLT 789

Query: 233  SPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKL------RVRILIDG 286
              P ++TV + + ALL CRA   P   T TW   D        L+L      R R    G
Sbjct: 790  ELPRDVTVELGRSALLACRATGRPPP-TVTWRRGDGQPL---GLRLGAGRGSRSRQPDSG 845

Query: 287  TLIIFRVKPEDSGKYTCVPSNSLGR-SPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIR 345
             L    V PED   Y C   N  G+    A   +T   P ++ +  P + V  G    + 
Sbjct: 846  VLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLP 905

Query: 346  CPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGT 405
            C V A  P     W KDGRPL        ++  DGS+ ++ A +E  G Y+CV  NT G+
Sbjct: 906  CIVLAGRPLPERHWLKDGRPLPPGSR--HSIRADGSLHLDRALQEHAGRYSCVATNTAGS 963

Query: 406  MGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSK- 464
              Q     LV++ PP            E G    +PC A+G P P ITW K      S+ 
Sbjct: 964  --QHRDVELVVQVPPRIHPTATHHITNE-GVPASLPCVASGVPAPTITWTKETNALTSRG 1020

Query: 465  --HSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTV 505
              ++    G+L     S +D G + C ATN V   +    L+V
Sbjct: 1021 PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 1063



 Score =  148 bits (374), Expect = 3e-35
 Identities = 156/589 (26%), Positives = 238/589 (40%), Gaps = 48/589 (8%)

Query: 30   PEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGR 89
            P FV   A   +VL C V      +P P +  W + G+ +           H      GR
Sbjct: 3588 PRFVVGLAPGQLVLECSV----EAEPAPKIT-WHRDGIVLQ-------EDAHTQFPERGR 3635

Query: 90   ASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYI 149
                    L+L+ + + D G Y C       +           + I+  PT    PP  +
Sbjct: 3636 F-------LQLQALSTADSGDYSCTA-----RNAAGSTSVAFRVEIHTVPTIRSGPPA-V 3682

Query: 150  EAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGA-SGKYQV-SDGSLTVTSVSREDRGAYT 207
                  +  + C A G P P+V+W K+   L   S ++++  +GSL +  V  +D G Y 
Sbjct: 3683 NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL 3742

Query: 208  CRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQD 267
            C A +  G       L V  PP I   P N+T+     ALL C A   P  L    +W+D
Sbjct: 3743 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVV--WWKD 3800

Query: 268  ENVYFQNDLKLR---VRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
                 + D +L+    R+L    L++    P+DS ++ CV SN +G +      +TV  P
Sbjct: 3801 GQ---KLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEA-HRLYQVTVHVP 3856

Query: 325  ARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRI 384
              + +      V +     + C      PA  V W+K G  L   +  G+ +   G++ I
Sbjct: 3857 PTIADDQTDFTVTMMAPVVLTCH-STGIPAPTVSWSKAGAQLGA-RGSGYRVSPSGALEI 3914

Query: 385  EEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAA 444
             +A     G YTC   N+ G   +     L ++  P    LP    R  A  E+L+PC A
Sbjct: 3915 GQALPIHAGRYTCSARNSAGVAHKH--VFLTVQASPVVKPLPS-VVRAVAEEEVLLPCEA 3971

Query: 445  AGDPFPVITWRKVGKPSRSKHS--ALPSGSLQFRALSKEDHGEWECVATNVVTSITASTH 502
            +G P P ITW+K G    +  S   LP G L+    S ED G + C+A N   S    T 
Sbjct: 3972 SGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTR 4031

Query: 503  LTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPP 562
            L V    P    +    +S T  + ++ P    G  +    W K  Q          + P
Sbjct: 4032 LVV--QVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQP 4089

Query: 563  GPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEP 611
                LLV  LE + A  ++  A+N +G +     +T+  L  P+ T  P
Sbjct: 4090 SGE-LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI--LVLPVFTTLP 4135



 Score =  146 bits (369), Expect = 1e-34
 Identities = 139/478 (29%), Positives = 204/478 (42%), Gaps = 57/478 (11%)

Query: 142 TETPPQYIEAKE-----GGSITMTCTAFGNPKPIVTWLKEGTLLGAS-GKY-QVSDGSLT 194
           T+ PPQ + A       G +  ++C   G     +TW+++  +L AS G+  Q++D SL 
Sbjct: 514 TDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLE 573

Query: 195 VTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEA 254
           ++ +   D G Y C A +  G    +  LLV+  P +     +   +   +  ++C A  
Sbjct: 574 ISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASG 633

Query: 255 YPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPS 314
           YP   T    W  E+   Q D   R+ +   GTLII  V PED+G Y+C  +N +G    
Sbjct: 634 YP---TPHISWSRESQALQEDS--RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQE 688

Query: 315 ASAYLTVQY--PARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNL 372
               +T+ Y  P  V  +  V+ V VG    + C     PP  V+ W + G    +E  L
Sbjct: 689 T---VTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVI-WYRGG----LEMIL 740

Query: 373 GWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQ 432
                  G +RI  A E   GTYTC   N LG    SA  +L +   P  T LP  +   
Sbjct: 741 APEGSSSGKLRIPAAQERDAGTYTCRAVNELGDA--SAEIQLAVGHAPQLTELPR-DVTV 797

Query: 433 EAGRELLIPCAAAGDPFPVITWRK-----------VGKPSRSKHSALPSGSLQFRALSKE 481
           E GR  L+ C A G P P +TWR+            G+ SRS+     SG L F +++ E
Sbjct: 798 ELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQP--DSGVLFFESVAPE 855

Query: 482 DHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQTF 541
           D   + C A NV   + A   L V G   HAP   ++  S  T  V      +G      
Sbjct: 856 DQAPYVCEARNVFGKVQAEARLIVTG---HAP--PQIASSAPTVRV-----LEGQPVSLP 905

Query: 542 SVWMKRAQFGPHDWL--SLPVPPG-------PSWLLVDTLEPETAYQFSVLAQNKLGT 590
            + +         WL    P+PPG          L +D    E A ++S +A N  G+
Sbjct: 906 CIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGS 963



 Score =  146 bits (369), Expect = 1e-34
 Identities = 168/599 (28%), Positives = 229/599 (38%), Gaps = 106/599 (17%)

Query: 18   LAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGY 77
            LA   A  L E P  VT   G S +L C      TG+PPP V   ++ G   P+ ++ G 
Sbjct: 780  LAVGHAPQLTELPRDVTVELGRSALLACRA----TGRPPPTVT--WRRGDGQPLGLRLG- 832

Query: 78   YPPHVDPEYAGRASLH---DKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLT 134
                     AGR S     D   L  E V  EDQ  Y C+   +   +      + + +T
Sbjct: 833  ---------AGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNV---FGKVQAEARLIVT 880

Query: 135  INAPPTFTETPPQYIEAKEGGSITMTCTAF-GNPKPIVTWLKEGTLLGASGKYQV-SDGS 192
             +APP    + P  +   EG  +++ C    G P P   WLK+G  L    ++ + +DGS
Sbjct: 881  GHAPPQIASSAPT-VRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS 939

Query: 193  LTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRA 252
            L +    +E  G Y+C A +  G       L+VQ PP I     +   N    A L C A
Sbjct: 940  LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVA 999

Query: 253  EAYPGNLTYTWYW---------------------------QDENVYF----------QND 275
               P   T TW                             QD   Y             +
Sbjct: 1000 SGVPAP-TITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQE 1058

Query: 276  LKLRVR-------------ILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQ 322
            ++L V              +L  G+L + +V+  DSG Y C  SN  G S S    L VQ
Sbjct: 1059 MRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAG-SASHRYVLGVQ 1117

Query: 323  YPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSI 382
             P +V   P V+ V VG    + C  +  P    + W+KDG  LQ            GS+
Sbjct: 1118 VPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQ-LSWSKDGVVLQGRG-------PQGSV 1169

Query: 383  RIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPC 442
                      G Y C   N+ G        R VL+ P +          + AG    +PC
Sbjct: 1170 HFAAIRTSDAGRYRCEASNSAGVDAWEVELR-VLEPPHWGADETSGLLERVAGENASLPC 1228

Query: 443  AAAGDPFPVITWRKVGKPSRSKH-----SALPSGSLQFRALSKEDHGEWECVATNVVTSI 497
             A G P P +TWRK G  S   H     + L  GSL   ++S  D G++EC ATN V S 
Sbjct: 1229 PARGTPKPQVTWRK-GPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 1287

Query: 498  TASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYD-------GGYEQTFSVWMKRAQ 549
            +    L V     + P S+R       ANVS   G          G+     VW+K AQ
Sbjct: 1288 SRRAKLVV-----YVPPSIR--EDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQ 1339



 Score =  138 bits (347), Expect = 4e-32
 Identities = 122/412 (29%), Positives = 174/412 (42%), Gaps = 35/412 (8%)

Query: 98   LRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVH--LTINAPPTF---TETPPQYIEAK 152
            L++  VR+E+ G Y CK               W+H  L +  PP     TE   + +   
Sbjct: 2806 LQIPLVRAENAGRYSCKA-------SNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVN 2858

Query: 153  EGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQV-SDGS-LTVTSVSREDRGAYTCRA 210
               ++++ C A GNP P ++WL+ G     S + QV  DG  L V++    D  +Y C A
Sbjct: 2859 ASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVA 2918

Query: 211  YSIQGEAVHTTHLLVQGPPFIVS-PPENITVNISQDALLTCRAEAYPGNLTYTWYWQDEN 269
             +  G A     L VQ PP I     E +T  ++    L C   A+P N   TWY   + 
Sbjct: 2919 ENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHP-NPEVTWYKDSQA 2977

Query: 270  VYFQNDLKLRVRILIDG--TLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARV 327
            +    ++      L+ G  TL + R +  DSG YTC   N+ GR       L+V  P   
Sbjct: 2978 LSLGEEV-----FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL-VQLSVLVPPAF 3031

Query: 328  LNMP----PVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIR 383
               P      + V VG    + C  DA P  TV  W KDG+PL + +     L     + 
Sbjct: 3032 RQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVT-WYKDGQPLVLAQRT-QALRGGQRLE 3089

Query: 384  IEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCA 443
            I+EA     G Y+C   N  G   ++    L ++ PP F         Q AG  L++ C 
Sbjct: 3090 IQEAQVSDKGLYSCKVSNVAGEAVRT--FTLTVQVPPTFENPKTETVSQVAGSPLVLTCD 3147

Query: 444  AAGDPFPVITWRKVGKP--SRSKHSALP-SGSLQFRALSKEDHGEWECVATN 492
             +G P P +TW K   P  S + H  +   G LQ   L     G + CVA N
Sbjct: 3148 VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN 3199



 Score =  136 bits (343), Expect = 1e-31
 Identities = 138/511 (27%), Positives = 208/511 (40%), Gaps = 69/511 (13%)

Query: 27   REEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEY 86
            R   + V  R G+  VL C+     T   P   V W+K G P+ +  +            
Sbjct: 3036 RGPQDAVLVRVGDKAVLSCE-----TDALPEPTVTWYKDGQPLVLAQR------------ 3078

Query: 87   AGRASLHDKASLRLEQVRSEDQGWYECKVL-MLDQQYDTFHNGSWVHLTINAPPTFTETP 145
                +L     L +++ +  D+G Y CKV  +  +   TF       LT+  PPTF    
Sbjct: 3079 --TQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFT------LTVQVPPTFENPK 3130

Query: 146  PQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQV--SDGSLTVTSVSREDR 203
             + +    G  + +TC   G P P VTWLK+   + +S  + V    G L ++ +     
Sbjct: 3131 TETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQA 3190

Query: 204  GAYTCRAYSIQGEAVHTTHLLVQGPPFIVSP--PENITVNISQDALLTCRAEAYPGNLTY 261
            G YTC A + Q EA     + V   P I S        V   Q+  L C A+  P     
Sbjct: 3191 GTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQP---PP 3247

Query: 262  TWYWQDENVYFQNDLKLRVRILID-GTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLT 320
               W  +      D+   +R  +D G+L++  ++  D+G YTCV  N  G          
Sbjct: 3248 DVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARL----- 3302

Query: 321  VQYPARVLNMPPVIYVPVGIHGYI----------RCPVDAEPPATVVKWNKDGRPLQVEK 370
              +   VL +PP I       G +           CPV   PP   V W KDG PL + +
Sbjct: 3303 --HTVNVL-VPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIH-VSWLKDGLPLPLSQ 3358

Query: 371  NLGWTLMEDG--SIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGW 428
                TL+     ++RI +      G +TCV  +  G   ++    L ++ PP   VL   
Sbjct: 3359 R---TLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRN--FTLQVQVPP---VLEPV 3410

Query: 429  EYRQEA----GRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSKEDHG 484
            E++ +     G  + +PC A G P P+++W K G+P  S+ S     SLQ  A+   D G
Sbjct: 3411 EFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQ-SLEQGPSLQLEAVGAGDSG 3469

Query: 485  EWECVATNVVTSITASTHLTVIGTSPHAPGS 515
             + CVA +          LTV+   PH   S
Sbjct: 3470 TYSCVAVSEAGEARRHFQLTVM-EPPHIEDS 3499



 Score =  134 bits (338), Expect = 5e-31
 Identities = 156/612 (25%), Positives = 252/612 (41%), Gaps = 88/612 (14%)

Query: 33   VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
            + +R GE V + C    PV G PP +V  W K G+P+P+               + R  L
Sbjct: 3323 LVSRPGELVTMVC----PVRGSPPIHV-SWLKDGLPLPL---------------SQRTLL 3362

Query: 93   HDKA-SLRLEQVRSEDQGWYECKVL----MLDQQYDTFHNGSWVHLTINAPPTFTETPPQ 147
            H    +LR+ +V+  D G + C       + D+ +          L +  PP       Q
Sbjct: 3363 HGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFT---------LQVQVPPVLEPVEFQ 3413

Query: 148  Y-IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSREDRGAY 206
              +    G  + + C A G P P+V+W+K+G  L +    Q    SL + +V   D G Y
Sbjct: 3414 NDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQ--GPSLQLEAVGAGDSGTY 3471

Query: 207  TCRAYSIQGEAVHTTHLLVQGPPFI--VSPPENITVNISQDALLTCRAEAYPGNLTYTWY 264
            +C A S  GEA     L V  PP I     P  +++       L C A+  P     TW+
Sbjct: 3472 SCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTP-QPNITWH 3530

Query: 265  WQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
               + +    +     R+L          +  D+G YTC+  +  G +   S  + VQ P
Sbjct: 3531 KDGQALTRLENNSRATRVL----------RVRDAGLYTCLAESPAG-AIEKSFRVRVQAP 3579

Query: 325  ARVLNMPPVIYVPVGI---HGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGS 381
              ++      +V VG+      + C V+AE PA  + W++DG  LQ + +  +   E G 
Sbjct: 3580 PNIVGPRGPRFV-VGLAPGQLVLECSVEAE-PAPKITWHRDGIVLQEDAHTQFP--ERGR 3635

Query: 382  -IRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLI 440
             ++++  +    G Y+C   N  G+   S   R+ +   P     P         +  L+
Sbjct: 3636 FLQLQALSTADSGDYSCTARNAAGS--TSVAFRVEIHTVPTIRSGPP-AVNVSVNQTALL 3692

Query: 441  PCAAAGDPFPVITWRKVG---KPSRSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSI 497
            PC A G P P+++WRK      P   +   LP GSL+ + +  +D G + C+A+N   S 
Sbjct: 3693 PCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSD 3752

Query: 498  TASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMK-------RAQF 550
                 L V+     AP      +++T    +  P    G  +   VW K       R Q 
Sbjct: 3753 RQGRDLRVLEPPAIAPSP--SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQ 3810

Query: 551  GPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVN---TLA---- 603
            G +  L        + LL+    P+ + QF  +  N++G +     VTV+   T+A    
Sbjct: 3811 GAYRLLP------SNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQT 3864

Query: 604  -FPITTPEPLVL 614
             F +T   P+VL
Sbjct: 3865 DFTVTMMAPVVL 3876



 Score =  124 bits (310), Expect = 8e-28
 Identities = 134/504 (26%), Positives = 204/504 (40%), Gaps = 39/504 (7%)

Query: 33   VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVD-PEYAGRAS 91
            V+  AG+S+ L CD      G P P +V W K    + + + +  Y   +   +  G   
Sbjct: 1310 VSGMAGQSLTLECDA----NGFPVPEIV-WLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 1364

Query: 92   LHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTET-PPQYIE 150
            L +  SL   +++  D G Y C+    + Q  T       HL +  PP+       Q + 
Sbjct: 1365 LDEGQSLHFPRIQEGDSGLYSCRA---ENQAGTAQRD--FHLLVLTPPSVLGAGAAQEVL 1419

Query: 151  AKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKY-QVSDGS--LTVTSVSREDRGAYT 207
               G  + + C   G P P V W K+   +   G + QV +    L +T     D G Y 
Sbjct: 1420 GLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQ 1479

Query: 208  CRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDAL--LTCRAEAYP-GNLTYTWY 264
            C A+S  G+      L V  PP I    E   V + +D L  L C A   P  N+T    
Sbjct: 1480 CVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT---- 1535

Query: 265  WQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
            W  +        K+ V       L + R +  D+G YTC  SN++G +  A+  L V  P
Sbjct: 1536 WFKDGALLPTSTKV-VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATR-LDVYVP 1593

Query: 325  ARVL---NMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGS 381
              +      P V+    G    + C     P  T + W+ +G P+  E N    L  DGS
Sbjct: 1594 PTIEGAGGRPYVVKAVAGRPVALECVARGHPSPT-LSWHHEGLPV-AESNES-RLETDGS 1650

Query: 382  I-RIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPG-WEYRQEAGRELL 439
            + R+E   E + G Y+CV  +  G         + +  PP   V  G  +     G+ L 
Sbjct: 1651 VLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV--PPQLLVAEGLGQVTTIVGQPLE 1708

Query: 440  IPCAAAGDPFPVITWRKVGKPSR---SKHSALPSGSLQFRALSKEDHGEWECVATNVVTS 496
            +PC A+G P P I W + G+P+        A    +L    +  +  G + C ATN   +
Sbjct: 1709 LPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGT 1768

Query: 497  ITASTHLTVIGTSPHAPGSVRVQV 520
              A   ++V G    APG + V +
Sbjct: 1769 AGAEVEVSVHG--EWAPGVLEVPI 1790



 Score =  119 bits (299), Expect = 2e-26
 Identities = 140/576 (24%), Positives = 237/576 (41%), Gaps = 55/576 (9%)

Query: 33   VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
            V+  A ESV L C      +   PP V+ W+K G P+             +P      S 
Sbjct: 2080 VSVVANESVALECQ-----SHAMPPPVLSWWKDGRPL-------------EPRPGVHLSA 2121

Query: 93   HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAK 152
             DKA L++++    D G Y C+ L         H+    +L +   P F       +  +
Sbjct: 2122 -DKALLQVDRADVWDAGHYTCEALN-----QAGHSEKHYNLNVWVAPVFPLRESHTLTVR 2175

Query: 153  EGGSITMTCTAFGNPKPIVTWLKEGTLL---GASGKYQVSDGSLTVTSVSR-EDRGAYTC 208
            EG   +++C   G P P ++W K+G  L   GA  ++  + G L     ++    G YTC
Sbjct: 2176 EGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTC 2235

Query: 209  RAYSIQGEAVHTTHLLVQGPPFIVSPPENIT-VNISQD--ALLTCRAEAYPGNLTYTWYW 265
               ++ G +     L V  PP I  P E  T V++ QD  A L C A   P   T TW  
Sbjct: 2236 ECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP-TVTWER 2294

Query: 266  QDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPA 325
              + V  +  L+L+ +     +L + R +   +G+Y+CV  N  GR+        +  P 
Sbjct: 2295 DGQPVGAELGLQLQNQ---GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPE 2351

Query: 326  RVLNMPPVIYVPVGIHGYIRCPVDA---EPPATVVKWNKDGRPLQVEKNLGWTLMEDGSI 382
             + ++ P+  +   +H  +    +A    PPA  ++W +   P+   ++  + L     +
Sbjct: 2352 LIGDLDPLTNITAALHSPLTLLCEAMGIPPPA--IRWFRGEEPVSPGEDT-YLLAGGWML 2408

Query: 383  RIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWE-YRQEAGRELLIP 441
            ++ +  E+  G Y+C+  N  G   ++    +++  PP        E  +   G+   + 
Sbjct: 2409 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLDGQTAHLM 2466

Query: 442  CAAAGDPFPVITWRKVGKP--SRSKHSALPSG-SLQFRALSKEDHGEWECVATNVVTSIT 498
            C   G P P +TW K G+P      H   P G  LQ    +    G + C+A N V   T
Sbjct: 2467 CNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKT 2526

Query: 499  ASTHLTVIGTSP----HAPGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFGPHD 554
                L+V+  +P     A  S   +V++T  N          +      WMK     P +
Sbjct: 2527 KHFQLSVL-LAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDG--APFE 2583

Query: 555  -WLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLG 589
               ++ + PG   L +   + E A Q++ +  N+LG
Sbjct: 2584 ASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 2619



 Score =  119 bits (299), Expect = 2e-26
 Identities = 152/603 (25%), Positives = 239/603 (39%), Gaps = 83/603 (13%)

Query: 33   VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
            +TA     + L C+ +    G PPP  + WF+   P+          P  D        +
Sbjct: 2362 ITAALHSPLTLLCEAM----GIPPP-AIRWFRGEEPVS---------PGEDTYLLAGGWM 2407

Query: 93   HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTF-TETPPQYIEA 151
                 L++ Q + +D G Y C  L  ++  +   N S   + +  PP+   E   + I+ 
Sbjct: 2408 -----LKMTQTQEQDSGLYSC--LASNEAGEARRNFS---VEVLVPPSIENEDLEEVIKV 2457

Query: 152  KEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVS-DG-SLTVTSVSREDRGAYTCR 209
             +G +  + C   G+P+P +TW K+G  L     + +S DG  L V   +    G Y+C 
Sbjct: 2458 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 2517

Query: 210  AYSIQGEAVHTTHLLVQGPPFIV-----SPPENITVNISQDALLTCRAEAYPG-NLTYTW 263
            A +  GE      L V   P I+     S  E +TV ++    L C A A+P  N+T   
Sbjct: 2518 AANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNIT--- 2574

Query: 264  YWQDENVYFQNDLKLRVRILIDGT--LIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTV 321
             W  +   F+    ++   L+ GT  L I   + ED+G+YTCV +N LG +   + ++ V
Sbjct: 2575 -WMKDGAPFEASRNIQ---LLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVK-NYHVEV 2629

Query: 322  QYPARVLNMPPV-------IYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGW 374
              P  +    P+       +   V     + C   A PP T ++W KDG+P+     L  
Sbjct: 2630 LIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPT-IRWYKDGQPVTPSSRL-Q 2687

Query: 375  TLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGW------ 428
             L E   ++I+       G Y CV  N  G   Q     ++++ PP F  +  +      
Sbjct: 2688 VLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD--FNVLIQVPPMFQKVGDFSAAFEI 2745

Query: 429  ------------EYRQ-EAGRELLIPCAAAGDPFPVITWRKVGKP--SRSKHSALPSGS- 472
                        EYR+        + C     P P +TW +  +P  +  + S L  G  
Sbjct: 2746 LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRV 2805

Query: 473  LQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTAN----VS 528
            LQ   +  E+ G + C A+N V        L V+ T P   G     V   T N    VS
Sbjct: 2806 LQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL-TPPVILGDTEELVEEVTVNASSTVS 2864

Query: 529  WEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKL 588
             +    G    T S       F P     L V      L V T E   A  +  +A+N+ 
Sbjct: 2865 LQCPALGNPVPTISWLQNGLPFSPSP--RLQVLEDGQVLQVSTAEVADAASYMCVAENQA 2922

Query: 589  GTS 591
            G++
Sbjct: 2923 GSA 2925



 Score =  119 bits (298), Expect = 2e-26
 Identities = 126/479 (26%), Positives = 192/479 (40%), Gaps = 52/479 (10%)

Query: 31   EFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRA 90
            E VTA    SV L CDV       P P V  W+K    + +  +    P           
Sbjct: 2945 EQVTAILNSSVSLPCDV----HAHPNPEVT-WYKDSQALSLGEEVFLLP----------- 2988

Query: 91   SLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETP--PQ- 147
                  +L+L + R  D G Y C+ L          +   V L++  PP F + P  PQ 
Sbjct: 2989 ---GTHTLQLGRARLSDSGMYTCEALNA-----AGRDQKLVQLSVLVPPAFRQAPRGPQD 3040

Query: 148  YIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGS--LTVTSVSREDRGA 205
             +  + G    ++C     P+P VTW K+G  L  + + Q   G   L +      D+G 
Sbjct: 3041 AVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGL 3100

Query: 206  YTCRAYSIQGEAVHTTHLLVQGPPFIVSP-PENITVNISQDALLTCRAEAYPGNLTYTWY 264
            Y+C+  ++ GEAV T  L VQ PP   +P  E ++       +LTC     P   T TW 
Sbjct: 3101 YSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAP-TVTWL 3159

Query: 265  WQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
                 V       +   +   G L + R++P  +G YTCV  N+   +        +  P
Sbjct: 3160 KDRMPV---ESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAP 3216

Query: 325  -ARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTL---MEDG 380
              R   +    +V  G    + C  D +PP  V  W KDG PL   +++G  L   ++ G
Sbjct: 3217 RIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVA-WLKDGSPL--GQDMGPHLRFYLDGG 3273

Query: 381  SIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWE----YRQEAGR 436
            S+ ++       G YTCV +N  G   +     +++  PP  T+  G +         G 
Sbjct: 3274 SLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV--PP--TIKQGADGSGTLVSRPGE 3329

Query: 437  ELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGS---LQFRALSKEDHGEWECVATN 492
             + + C   G P   ++W K G P       L  GS   L+   +   D G + CVA +
Sbjct: 3330 LVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAAS 3388



 Score =  116 bits (290), Expect = 2e-25
 Identities = 163/647 (25%), Positives = 240/647 (37%), Gaps = 80/647 (12%)

Query: 33   VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
            V   AG  V L+C      +G P P V EW K   P+   +  G   PH+  +  G+   
Sbjct: 1418 VLGLAGADVELQCWT----SGVPTPQV-EWTKDRQPV---LPGG---PHLQVQEDGQV-- 1464

Query: 93   HDKASLRLEQVRSEDQGWYECKVLM-LDQQYDTFHNGSWVHLTINAPPT-FTETPPQYIE 150
                 LR+      D+G Y+C       QQ   F       L ++APPT +       + 
Sbjct: 1465 -----LRITGSHVGDEGRYQCVAFSPAGQQARDFQ------LRVHAPPTIWGSNETGEVA 1513

Query: 151  AKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGS--LTVTSVSREDRGAYTC 208
              E   + + C A G P P +TW K+G LL  S K   + G   L +      D G YTC
Sbjct: 1514 VMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTC 1573

Query: 209  RAYSIQGEAVHTTHLLVQGPPFIVSP---PENITVNISQDALLTCRAEAYPGNLTYTWYW 265
            +A +  G A   T L V  PP I      P  +     +   L C A  +P   T +W+ 
Sbjct: 1574 KASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP-TLSWHH 1632

Query: 266  QDENVYFQNDLKLRVRILIDGTLIIFRVKPE-DSGKYTCVPSNSLGRSPSASAYLTVQYP 324
            +   V   N+ +L      DG+++      E  SG Y+CV S     SP+  A L  QY 
Sbjct: 1633 EGLPVAESNESRLET----DGSVLRLESPGEASSGLYSCVAS-----SPAGEAVL--QYS 1681

Query: 325  ARVLNMPPVIYVPVGIHGY-------IRCPVDAE-PPATVVKWNKDGRPLQVEKNLGWTL 376
              V  +PP + V  G+          +  P  A   P   ++W ++GRP   E+  G  +
Sbjct: 1682 VEV-QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP--AEELAGVQV 1738

Query: 377  MEDGS-IRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAG 435
               G+ + I+    +  G + C   N  GT G      +  +  P    +P  +Y     
Sbjct: 1739 ASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXE 1798

Query: 436  RELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSG----------------SLQFRALS 479
                 P  AA DP     W    KP   +    P                   LQ   + 
Sbjct: 1799 HHSSFP--AACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVD 1856

Query: 480  KEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQ 539
              D G + C ATN+         L V+      PG V   V +  A+V+ E    G    
Sbjct: 1857 LRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAV-LENASVTLECLASGVPPP 1915

Query: 540  TFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTV 599
              S W K  Q     W+ + V      L ++  +   A  +  +A N  G++     + V
Sbjct: 1916 DVS-WFKGHQ-PVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRV 1973

Query: 600  NT---LAFPITTPEPLVLVTPPRCLIANRTQQGVLLSWLPPANHSFP 643
            N    +  P + P P+++ TP R            L WL   N   P
Sbjct: 1974 NVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSP 2020



 Score =  116 bits (290), Expect = 2e-25
 Identities = 129/497 (25%), Positives = 186/497 (37%), Gaps = 44/497 (8%)

Query: 40   SVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLR 99
            SV L C      +G PPP V  WFK   P+                + G     D   LR
Sbjct: 1902 SVTLEC----LASGVPPPDV-SWFKGHQPVS--------------SWMGVTVSVDGRVLR 1942

Query: 100  LEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITM 159
            +EQ +  D G Y C    +    +  +      L +N PP  T  P           + +
Sbjct: 1943 IEQAQLSDAGSYRCVASNVAGSTELRYG-----LRVNVPPRITLPPSLPGPVLVNTPVRL 1997

Query: 160  TCTAFGNPKPIVTWLKEGTLLGASGK--YQVSDGS--LTVTSVSREDRGAYTCRAYSIQG 215
            TC A G P P + WLK+G  +  +G    QV  G   LT+ S    D G Y+C A S  G
Sbjct: 1998 TCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG 2057

Query: 216  EAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQND 275
            E      L V  PP I+    N++V  ++   L C++ A P  +  +W W+D       +
Sbjct: 2058 EDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSW-WKDGRPL---E 2112

Query: 276  LKLRVRILIDGTLI-IFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVI 334
             +  V +  D  L+ + R    D+G YTC   N  G S           P   L     +
Sbjct: 2113 PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTL 2172

Query: 335  YVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVE-KNLGWTLMEDGSIRIEEATEEALG 393
             V  G    + C      P   + W KDG+PL  E   L         + + +A     G
Sbjct: 2173 TVREGHPTSLSCECRG-VPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEG 2231

Query: 394  TYTCVPYNTLGTMGQSAPARLVLKDPPYFT--VLPGWEYRQEAGRELLIPCAAAGDPFPV 451
            TYTC   N +G   Q    +L +  PP       P  +          + C A G P P 
Sbjct: 2232 TYTCECSNVVGNSSQD--LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT 2289

Query: 452  ITWRKVGKPSRSK---HSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGT 508
            +TW + G+P  ++          SL          G + CVA N+         L+V+  
Sbjct: 2290 VTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL-V 2348

Query: 509  SPHAPGSVRVQVSMTTA 525
             P   G +    ++T A
Sbjct: 2349 PPELIGDLDPLTNITAA 2365



 Score =  103 bits (258), Expect = 9e-22
 Identities = 121/453 (26%), Positives = 180/453 (39%), Gaps = 65/453 (14%)

Query: 97   SLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVH---LTINAPPTFTETPPQYIEAKE 153
            SLRL QV+  D G YEC          +   GS  H   L +  PP   +  P+ ++   
Sbjct: 1083 SLRLAQVQVGDSGHYECTA--------SNPAGSASHRYVLGVQVPPQ-VQPGPRVLKVLV 1133

Query: 154  GGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSREDRGAYTCRAYSI 213
            G ++ + C A GNP+P ++W K+G +L   G      GS+   ++   D G Y C A + 
Sbjct: 1134 GEALDLNCVAEGNPEPQLSWSKDGVVLQGRG----PQGSVHFAAIRTSDAGRYRCEASNS 1189

Query: 214  QGEAVHTTHLLVQGPPFIVSPPENITVN--ISQDALLTCRAEAYP-GNLTYTWYWQDENV 270
             G       L V  PP   +   +  +     ++A L C A   P   +T+      E +
Sbjct: 1190 AGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPL 1249

Query: 271  YFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNM 330
            + Q      V +L +G+L +  V P DSG Y C  +N +G S S  A L V  P  +   
Sbjct: 1250 HGQPG----VAVLEEGSLFLASVSPADSGDYECQATNEVG-STSRRAKLVVYVPPSIRED 1304

Query: 331  PPVIYVPVGIHGY---IRCPVDAEPPATVVKWNKDGRPLQVEK-------NLGW------ 374
                 V  G+ G    + C  +  P   +V W KD + + V         +LGW      
Sbjct: 1305 GRKANVS-GMAGQSLTLECDANGFPVPEIV-WLKDAQLVGVPLGWAGYGWDLGWGQVGGH 1362

Query: 375  TLMEDG-SIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQE 433
             L+++G S+      E   G Y+C   N  GT  Q     LVL  P         E    
Sbjct: 1363 RLLDEGQSLHFPRIQEGDSGLYSCRAENQAGT-AQRDFHLLVLTPPSVLGAGAAQEVLGL 1421

Query: 434  AGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGS----------LQFRALSKEDH 483
            AG ++ + C  +G P P + W K  +P       LP G           L+       D 
Sbjct: 1422 AGADVELQCWTSGVPTPQVEWTKDRQP------VLPGGPHLQVQEDGQVLRITGSHVGDE 1475

Query: 484  GEWECVATNVVTSITASTHLTVIGTSPHAPGSV 516
            G ++CVA +          L V     HAP ++
Sbjct: 1476 GRYQCVAFSPAGQQARDFQLRV-----HAPPTI 1503



 Score =  103 bits (257), Expect = 1e-21
 Identities = 93/337 (27%), Positives = 144/337 (42%), Gaps = 20/337 (5%)

Query: 180 LGASGKYQVS-DGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENI 238
           LG    +Q S + S  +   S+ + G Y C A S  G       ++V  PP  + P  N+
Sbjct: 467 LGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNV 526

Query: 239 TVNISQDALLTCR--AEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPE 296
           TV+  + A+L+CR   EA P NLT+   W+            RV  L D +L I  + P 
Sbjct: 527 TVSPGETAVLSCRVLGEA-PYNLTWVRDWR-----VLPASTGRVAQLADLSLEISGIIPT 580

Query: 297 DSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATV 356
           D G+Y CV SN+ G +  AS +L V+   +V       +   G+   + C      P   
Sbjct: 581 DGGRYQCVASNANGVT-RASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY-PTPH 638

Query: 357 VKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVL 416
           + W+++ + LQ +  +   +   G++ I+    E  G Y+C   N +GT        L  
Sbjct: 639 ISWSRESQALQEDSRI--HVDAQGTLIIQGVAPEDAGNYSCQATNEVGT--DQETVTLYY 694

Query: 417 KDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFR 476
            DPP  + +         G E ++ C A+G P P + W + G           SG L+  
Sbjct: 695 TDPPSVSAVNA-VVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIP 753

Query: 477 ALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAP 513
           A  + D G + C A N +   +A   L V     HAP
Sbjct: 754 AAQERDAGTYTCRAVNELGDASAEIQLAV----GHAP 786



 Score =  102 bits (255), Expect = 2e-21
 Identities = 145/583 (24%), Positives = 201/583 (34%), Gaps = 144/583 (24%)

Query: 38   GESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKAS 97
            G+ V L C V+    G+P P    W K G P+P                  R S+    S
Sbjct: 899  GQPVSLPCIVL---AGRPLPER-HWLKDGRPLPP---------------GSRHSIRADGS 939

Query: 98   LRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSI 157
            L L++   E  G Y C   +      + H    V L +  PP    T   +I   EG   
Sbjct: 940  LHLDRALQEHAGRYSC---VATNTAGSQHRD--VELVVQVPPRIHPTATHHI-TNEGVPA 993

Query: 158  TMTCTAFGNPKPIVTWLKE----------------GTLLGASGKYQ-------------- 187
            ++ C A G P P +TW KE                GTLL A    Q              
Sbjct: 994  SLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVG 1053

Query: 188  -------------------------VSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTH 222
                                     +  GSL +  V   D G Y C A +  G A H   
Sbjct: 1054 FSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYV 1113

Query: 223  LLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRI 282
            L VQ PP +   P  + V + +   L C AE   GN      W  + V  Q         
Sbjct: 1114 LGVQVPPQVQPGPRVLKVLVGEALDLNCVAE---GNPEPQLSWSKDGVVLQGRGP----- 1165

Query: 283  LIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMP--------PVI 334
               G++    ++  D+G+Y C  SNS G      A+   +   RVL  P         ++
Sbjct: 1166 --QGSVHFAAIRTSDAGRYRCEASNSAG----VDAW---EVELRVLEPPHWGADETSGLL 1216

Query: 335  YVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGT 394
                G +  + CP    P   V  W K      +    G  ++E+GS+ +   +    G 
Sbjct: 1217 ERVAGENASLPCPARGTPKPQVT-WRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGD 1275

Query: 395  YTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQE---------AGRELLIPCAAA 445
            Y C   N +G+   S  A+LV+  PP          R++         AG+ L + C A 
Sbjct: 1276 YECQATNEVGS--TSRRAKLVVYVPP--------SIREDGRKANVSGMAGQSLTLECDAN 1325

Query: 446  GDPFPVITWRK----VGKP-------------SRSKHSALPSG-SLQFRALSKEDHGEWE 487
            G P P I W K    VG P                 H  L  G SL F  + + D G + 
Sbjct: 1326 GFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYS 1385

Query: 488  CVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWE 530
            C A N   +     HL V+ T P   G+   Q  +  A    E
Sbjct: 1386 CRAENQAGTAQRDFHLLVL-TPPSVLGAGAAQEVLGLAGADVE 1427



 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 121/483 (25%), Positives = 183/483 (37%), Gaps = 58/483 (12%)

Query: 37   AGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKA 96
            AGE+  L C    P  G P P V  W K     P+         H  P  A    + ++ 
Sbjct: 1220 AGENASLPC----PARGTPKPQVT-WRKGPSSEPL---------HGQPGVA----VLEEG 1261

Query: 97   SLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQ-YIEAKEGG 155
            SL L  V   D G YEC+        +         L +  PP+  E   +  +    G 
Sbjct: 1262 SLFLASVSPADSGDYECQA-----TNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQ 1316

Query: 156  SITMTCTAFGNPKPIVTWLKEGTLLG----------------ASGKYQVSDG-SLTVTSV 198
            S+T+ C A G P P + WLK+  L+G                  G   + +G SL    +
Sbjct: 1317 SLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRI 1376

Query: 199  SREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIV--SPPENITVNISQDALLTCRAEAYP 256
               D G Y+CRA +  G A    HLLV  PP ++     + +      D  L C     P
Sbjct: 1377 QEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVP 1436

Query: 257  GNLTYTWYWQDENVYFQNDLKLRVRILIDGTLI-IFRVKPEDSGKYTCVPSNSLGRSPSA 315
                   + +D          L+V+   DG ++ I      D G+Y CV  +  G+  + 
Sbjct: 1437 --TPQVEWTKDRQPVLPGGPHLQVQ--EDGQVLRITGSHVGDEGRYQCVAFSPAGQQ-AR 1491

Query: 316  SAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAE-PPATVVKWNKDGRPLQVEKNLGW 374
               L V  P  +        V V     ++   +A   P   + W KDG  L     + +
Sbjct: 1492 DFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVY 1551

Query: 375  TLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEY--RQ 432
            T      +++  A     G YTC   N +G   ++   RL +  PP      G  Y  + 
Sbjct: 1552 T-RGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKA--TRLDVYVPPTIEGAGGRPYVVKA 1608

Query: 433  EAGRELLIPCAAAGDPFPVITWRKVGKP-SRSKHSALPSGS--LQFRALSKEDHGEWECV 489
             AGR + + C A G P P ++W   G P + S  S L +    L+  +  +   G + CV
Sbjct: 1609 VAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCV 1668

Query: 490  ATN 492
            A++
Sbjct: 1669 ASS 1671



 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 113/478 (23%), Positives = 182/478 (38%), Gaps = 49/478 (10%)

Query: 33   VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
            VT   G+ + L C      +G P P  ++W + G P                E AG    
Sbjct: 1699 VTTIVGQPLELPCQA----SGSPVP-TIQWLQNGRPAE--------------ELAGVQVA 1739

Query: 93   HDKASLRLEQVRSEDQGWYECKVL----MLDQQYDTFHNGSWVHLTINAPPTFTETPPQY 148
                +L ++ V  +  G + C+          + +   +G W    +  P        ++
Sbjct: 1740 SQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEH 1799

Query: 149  IEAKEGGSITMTCTAFG-NPKP--IVTWLKEGTLLGASGKYQVSDG---SLTVTSVSRED 202
              +            +G +PKP  +  W   G+L G      V+      L +  V   D
Sbjct: 1800 HSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRD 1859

Query: 203  RGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYT 262
             G YTC A ++ GE+     L V  PP I   P N  V  +    L C A   P     +
Sbjct: 1860 EGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPP-DVS 1918

Query: 263  WYWQDENVYFQNDLKLRVRILIDGTLI-IFRVKPEDSGKYTCVPSNSLGRSPSASAYLTV 321
            W+   + V       + V + +DG ++ I + +  D+G Y CV SN  G S      L V
Sbjct: 1919 WFKGHQPV----SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG-STELRYGLRV 1973

Query: 322  QYPARVLNMPPVIYVPVGIHGYIRCPVDAE-PPATVVKWNKDGRPLQVEKNLGWTLMEDG 380
              P R+  +PP +  PV ++  +R   +A   P+  + W KDG P+      G  +   G
Sbjct: 1974 NVPPRI-TLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGG 2032

Query: 381  SI-RIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQE--AGRE 437
             +  +  A     G Y+CV  + +G   Q    ++ +  PP    + G E      A   
Sbjct: 2033 RVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHM--PP---SILGEELNVSVVANES 2087

Query: 438  LLIPCAAAGDPFPVITWRKVGKPSRSK---HSALPSGSLQFRALSKEDHGEWECVATN 492
            + + C +   P PV++W K G+P   +   H +     LQ       D G + C A N
Sbjct: 2088 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALN 2145


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  150 bits (379), Expect = 8e-36
 Identities = 139/507 (27%), Positives = 206/507 (40%), Gaps = 50/507 (9%)

Query: 18   LAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGY 77
            L  + +  ++  P  V A A E V+L C+     +G P P  + W K G+ +   +    
Sbjct: 2660 LTVQASPVVKPLPSVVRAVAEEEVLLPCEA----SGIPRP-TITWQKEGLNVATGVSTQV 2714

Query: 78   YPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINA 137
             P                  LR+     ED G Y C       +           L +  
Sbjct: 2715 LPG---------------GQLRIAHASPEDAGNYLCIA-----KNSAGSAMGKTRLVVQV 2754

Query: 138  PPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGT-LLGASGKYQVS-DGSLTV 195
            PP      P  +   EG    + C A G+P+P +TW K+G  + GA GK+ +   G L V
Sbjct: 2755 PPVIENGLPD-LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLV 2813

Query: 196  TSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAY 255
             ++  +D G YTC A +  G A    HL +   P   + P + ++ +     L C A   
Sbjct: 2814 KNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGS 2873

Query: 256  PGNLTYTWYWQD----ENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGR 311
            P      W   D    E V  Q+            TL    V  EDSG Y C   N +GR
Sbjct: 2874 P-TPRIGWTVNDRPVTEGVSEQDG---------GSTLQRAAVSREDSGTYVCWAENRVGR 2923

Query: 312  SPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKN 371
            + + S     + P         +  PVG    + C V  + P   + W KDG PL+   +
Sbjct: 2924 TQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD-PVPDIHWIKDGLPLR-GSH 2981

Query: 372  LGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYR 431
            L   L ++GS+ I     +  G Y C+  N +G         LVL+  P F V P  +  
Sbjct: 2982 LRHQL-QNGSLTIRRTERDDAGRYQCLAENEMGV--AKKVVILVLQSAPVFQVEP-QDMT 3037

Query: 432  QEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKH--SALPSGSLQFRALSKEDHGEWECV 489
              +G ++ + C A G+P P I W + G+P R+      LP GSL    +   D G ++CV
Sbjct: 3038 VRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCV 3097

Query: 490  ATNVVTSITASTHLTVIGTSPHAPGSV 516
            A N++ S TA   L V G    + GS+
Sbjct: 3098 AHNLLGSATARAFLVVRGEPQGSWGSM 3124



 Score =  148 bits (374), Expect = 3e-35
 Identities = 156/589 (26%), Positives = 238/589 (40%), Gaps = 48/589 (8%)

Query: 30   PEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGR 89
            P FV   A   +VL C V      +P P +  W + G+ +           H      GR
Sbjct: 2306 PRFVVGLAPGQLVLECSV----EAEPAPKIT-WHRDGIVLQ-------EDAHTQFPERGR 2353

Query: 90   ASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYI 149
                    L+L+ + + D G Y C       +           + I+  PT    PP  +
Sbjct: 2354 F-------LQLQALSTADSGDYSCTA-----RNAAGSTSVAFRVEIHTVPTIRSGPPA-V 2400

Query: 150  EAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGA-SGKYQV-SDGSLTVTSVSREDRGAYT 207
                  +  + C A G P P+V+W K+   L   S ++++  +GSL +  V  +D G Y 
Sbjct: 2401 NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL 2460

Query: 208  CRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQD 267
            C A +  G       L V  PP I   P N+T+     ALL C A   P  L    +W+D
Sbjct: 2461 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVV--WWKD 2518

Query: 268  ENVYFQNDLKLR---VRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
                 + D +L+    R+L    L++    P+DS ++ CV SN +G +      +TV  P
Sbjct: 2519 GQ---KLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEA-HRLYQVTVHVP 2574

Query: 325  ARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRI 384
              + +      V +     + C      PA  V W+K G  L   +  G+ +   G++ I
Sbjct: 2575 PTIADDQTDFTVTMMAPVVLTCH-STGIPAPTVSWSKAGAQLGA-RGSGYRVSPSGALEI 2632

Query: 385  EEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAA 444
             +A     G YTC   N+ G   +     L ++  P    LP    R  A  E+L+PC A
Sbjct: 2633 GQALPIHAGRYTCSARNSAGVAHKH--VFLTVQASPVVKPLPS-VVRAVAEEEVLLPCEA 2689

Query: 445  AGDPFPVITWRKVGKPSRSKHS--ALPSGSLQFRALSKEDHGEWECVATNVVTSITASTH 502
            +G P P ITW+K G    +  S   LP G L+    S ED G + C+A N   S    T 
Sbjct: 2690 SGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTR 2749

Query: 503  LTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPP 562
            L V    P    +    +S T  + ++ P    G  +    W K  Q          + P
Sbjct: 2750 LVV--QVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQP 2807

Query: 563  GPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEP 611
                LLV  LE + A  ++  A+N +G +     +T+  L  P+ T  P
Sbjct: 2808 SGE-LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI--LVLPVFTTLP 2853



 Score =  138 bits (347), Expect = 4e-32
 Identities = 122/412 (29%), Positives = 174/412 (42%), Gaps = 35/412 (8%)

Query: 98   LRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVH--LTINAPPTF---TETPPQYIEAK 152
            L++  VR+E+ G Y CK               W+H  L +  PP     TE   + +   
Sbjct: 1524 LQIPLVRAENAGRYSCKA-------SNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVN 1576

Query: 153  EGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQV-SDGS-LTVTSVSREDRGAYTCRA 210
               ++++ C A GNP P ++WL+ G     S + QV  DG  L V++    D  +Y C A
Sbjct: 1577 ASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVA 1636

Query: 211  YSIQGEAVHTTHLLVQGPPFIVS-PPENITVNISQDALLTCRAEAYPGNLTYTWYWQDEN 269
             +  G A     L VQ PP I     E +T  ++    L C   A+P N   TWY   + 
Sbjct: 1637 ENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHP-NPEVTWYKDSQA 1695

Query: 270  VYFQNDLKLRVRILIDG--TLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARV 327
            +    ++      L+ G  TL + R +  DSG YTC   N+ GR       L+V  P   
Sbjct: 1696 LSLGEEV-----FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL-VQLSVLVPPAF 1749

Query: 328  LNMP----PVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIR 383
               P      + V VG    + C  DA P  TV  W KDG+PL + +     L     + 
Sbjct: 1750 RQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVT-WYKDGQPLVLAQRT-QALRGGQRLE 1807

Query: 384  IEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCA 443
            I+EA     G Y+C   N  G   ++    L ++ PP F         Q AG  L++ C 
Sbjct: 1808 IQEAQVSDKGLYSCKVSNVAGEAVRT--FTLTVQVPPTFENPKTETVSQVAGSPLVLTCD 1865

Query: 444  AAGDPFPVITWRKVGKP--SRSKHSALP-SGSLQFRALSKEDHGEWECVATN 492
             +G P P +TW K   P  S + H  +   G LQ   L     G + CVA N
Sbjct: 1866 VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN 1917



 Score =  136 bits (343), Expect = 1e-31
 Identities = 138/511 (27%), Positives = 208/511 (40%), Gaps = 69/511 (13%)

Query: 27   REEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEY 86
            R   + V  R G+  VL C+     T   P   V W+K G P+ +  +            
Sbjct: 1754 RGPQDAVLVRVGDKAVLSCE-----TDALPEPTVTWYKDGQPLVLAQR------------ 1796

Query: 87   AGRASLHDKASLRLEQVRSEDQGWYECKVL-MLDQQYDTFHNGSWVHLTINAPPTFTETP 145
                +L     L +++ +  D+G Y CKV  +  +   TF       LT+  PPTF    
Sbjct: 1797 --TQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFT------LTVQVPPTFENPK 1848

Query: 146  PQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQV--SDGSLTVTSVSREDR 203
             + +    G  + +TC   G P P VTWLK+   + +S  + V    G L ++ +     
Sbjct: 1849 TETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQA 1908

Query: 204  GAYTCRAYSIQGEAVHTTHLLVQGPPFIVSP--PENITVNISQDALLTCRAEAYPGNLTY 261
            G YTC A + Q EA     + V   P I S        V   Q+  L C A+  P     
Sbjct: 1909 GTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQP---PP 1965

Query: 262  TWYWQDENVYFQNDLKLRVRILID-GTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLT 320
               W  +      D+   +R  +D G+L++  ++  D+G YTCV  N  G          
Sbjct: 1966 DVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARL----- 2020

Query: 321  VQYPARVLNMPPVIYVPVGIHGYI----------RCPVDAEPPATVVKWNKDGRPLQVEK 370
              +   VL +PP I       G +           CPV   PP   V W KDG PL + +
Sbjct: 2021 --HTVNVL-VPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIH-VSWLKDGLPLPLSQ 2076

Query: 371  NLGWTLMEDG--SIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGW 428
                TL+     ++RI +      G +TCV  +  G   ++    L ++ PP   VL   
Sbjct: 2077 R---TLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRN--FTLQVQVPP---VLEPV 2128

Query: 429  EYRQEA----GRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSKEDHG 484
            E++ +     G  + +PC A G P P+++W K G+P  S+ S     SLQ  A+   D G
Sbjct: 2129 EFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQ-SLEQGPSLQLEAVGAGDSG 2187

Query: 485  EWECVATNVVTSITASTHLTVIGTSPHAPGS 515
             + CVA +          LTV+   PH   S
Sbjct: 2188 TYSCVAVSEAGEARRHFQLTVM-EPPHIEDS 2217



 Score =  134 bits (338), Expect = 5e-31
 Identities = 156/612 (25%), Positives = 252/612 (41%), Gaps = 88/612 (14%)

Query: 33   VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
            + +R GE V + C    PV G PP +V  W K G+P+P+               + R  L
Sbjct: 2041 LVSRPGELVTMVC----PVRGSPPIHV-SWLKDGLPLPL---------------SQRTLL 2080

Query: 93   HDKA-SLRLEQVRSEDQGWYECKVL----MLDQQYDTFHNGSWVHLTINAPPTFTETPPQ 147
            H    +LR+ +V+  D G + C       + D+ +          L +  PP       Q
Sbjct: 2081 HGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFT---------LQVQVPPVLEPVEFQ 2131

Query: 148  Y-IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSREDRGAY 206
              +    G  + + C A G P P+V+W+K+G  L +    Q    SL + +V   D G Y
Sbjct: 2132 NDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQ--GPSLQLEAVGAGDSGTY 2189

Query: 207  TCRAYSIQGEAVHTTHLLVQGPPFI--VSPPENITVNISQDALLTCRAEAYPGNLTYTWY 264
            +C A S  GEA     L V  PP I     P  +++       L C A+  P     TW+
Sbjct: 2190 SCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTP-QPNITWH 2248

Query: 265  WQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
               + +    +     R+L          +  D+G YTC+  +  G +   S  + VQ P
Sbjct: 2249 KDGQALTRLENNSRATRVL----------RVRDAGLYTCLAESPAG-AIEKSFRVRVQAP 2297

Query: 325  ARVLNMPPVIYVPVGI---HGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGS 381
              ++      +V VG+      + C V+AE PA  + W++DG  LQ + +  +   E G 
Sbjct: 2298 PNIVGPRGPRFV-VGLAPGQLVLECSVEAE-PAPKITWHRDGIVLQEDAHTQFP--ERGR 2353

Query: 382  -IRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLI 440
             ++++  +    G Y+C   N  G+   S   R+ +   P     P         +  L+
Sbjct: 2354 FLQLQALSTADSGDYSCTARNAAGS--TSVAFRVEIHTVPTIRSGPP-AVNVSVNQTALL 2410

Query: 441  PCAAAGDPFPVITWRKVG---KPSRSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSI 497
            PC A G P P+++WRK      P   +   LP GSL+ + +  +D G + C+A+N   S 
Sbjct: 2411 PCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSD 2470

Query: 498  TASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMK-------RAQF 550
                 L V+     AP      +++T    +  P    G  +   VW K       R Q 
Sbjct: 2471 RQGRDLRVLEPPAIAPSP--SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQ 2528

Query: 551  GPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVN---TLA---- 603
            G +  L        + LL+    P+ + QF  +  N++G +     VTV+   T+A    
Sbjct: 2529 GAYRLLP------SNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQT 2582

Query: 604  -FPITTPEPLVL 614
             F +T   P+VL
Sbjct: 2583 DFTVTMMAPVVL 2594



 Score =  124 bits (310), Expect = 8e-28
 Identities = 134/504 (26%), Positives = 204/504 (40%), Gaps = 39/504 (7%)

Query: 33  VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVD-PEYAGRAS 91
           V+  AG+S+ L CD      G P P +V W K    + + + +  Y   +   +  G   
Sbjct: 28  VSGMAGQSLTLECDA----NGFPVPEIV-WLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 82

Query: 92  LHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTET-PPQYIE 150
           L +  SL   +++  D G Y C+    + Q  T       HL +  PP+       Q + 
Sbjct: 83  LDEGQSLHFPRIQEGDSGLYSCRA---ENQAGTAQRD--FHLLVLTPPSVLGAGAAQEVL 137

Query: 151 AKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKY-QVSDGS--LTVTSVSREDRGAYT 207
              G  + + C   G P P V W K+   +   G + QV +    L +T     D G Y 
Sbjct: 138 GLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQ 197

Query: 208 CRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDAL--LTCRAEAYP-GNLTYTWY 264
           C A+S  G+      L V  PP I    E   V + +D L  L C A   P  N+T    
Sbjct: 198 CVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT---- 253

Query: 265 WQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
           W  +        K+ V       L + R +  D+G YTC  SN++G +  A+  L V  P
Sbjct: 254 WFKDGALLPTSTKV-VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATR-LDVYVP 311

Query: 325 ARVL---NMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGS 381
             +      P V+    G    + C     P  T + W+ +G P+  E N    L  DGS
Sbjct: 312 PTIEGAGGRPYVVKAVAGRPVALECVARGHPSPT-LSWHHEGLPV-AESNES-RLETDGS 368

Query: 382 I-RIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPG-WEYRQEAGRELL 439
           + R+E   E + G Y+CV  +  G         + +  PP   V  G  +     G+ L 
Sbjct: 369 VLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV--PPQLLVAEGLGQVTTIVGQPLE 426

Query: 440 IPCAAAGDPFPVITWRKVGKPSR---SKHSALPSGSLQFRALSKEDHGEWECVATNVVTS 496
           +PC A+G P P I W + G+P+        A    +L    +  +  G + C ATN   +
Sbjct: 427 LPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGT 486

Query: 497 ITASTHLTVIGTSPHAPGSVRVQV 520
             A   ++V G    APG + V +
Sbjct: 487 AGAEVEVSVHG--EWAPGVLEVPI 508



 Score =  119 bits (299), Expect = 2e-26
 Identities = 152/603 (25%), Positives = 239/603 (39%), Gaps = 83/603 (13%)

Query: 33   VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
            +TA     + L C+ +    G PPP  + WF+   P+          P  D        +
Sbjct: 1080 ITAALHSPLTLLCEAM----GIPPP-AIRWFRGEEPVS---------PGEDTYLLAGGWM 1125

Query: 93   HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTF-TETPPQYIEA 151
                 L++ Q + +D G Y C  L  ++  +   N S   + +  PP+   E   + I+ 
Sbjct: 1126 -----LKMTQTQEQDSGLYSC--LASNEAGEARRNFS---VEVLVPPSIENEDLEEVIKV 1175

Query: 152  KEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVS-DG-SLTVTSVSREDRGAYTCR 209
             +G +  + C   G+P+P +TW K+G  L     + +S DG  L V   +    G Y+C 
Sbjct: 1176 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 1235

Query: 210  AYSIQGEAVHTTHLLVQGPPFIV-----SPPENITVNISQDALLTCRAEAYPG-NLTYTW 263
            A +  GE      L V   P I+     S  E +TV ++    L C A A+P  N+T   
Sbjct: 1236 AANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNIT--- 1292

Query: 264  YWQDENVYFQNDLKLRVRILIDGT--LIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTV 321
             W  +   F+    ++   L+ GT  L I   + ED+G+YTCV +N LG +   + ++ V
Sbjct: 1293 -WMKDGAPFEASRNIQ---LLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVK-NYHVEV 1347

Query: 322  QYPARVLNMPPV-------IYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGW 374
              P  +    P+       +   V     + C   A PP T ++W KDG+P+     L  
Sbjct: 1348 LIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPT-IRWYKDGQPVTPSSRL-Q 1405

Query: 375  TLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGW------ 428
             L E   ++I+       G Y CV  N  G   Q     ++++ PP F  +  +      
Sbjct: 1406 VLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD--FNVLIQVPPMFQKVGDFSAAFEI 1463

Query: 429  ------------EYRQ-EAGRELLIPCAAAGDPFPVITWRKVGKP--SRSKHSALPSGS- 472
                        EYR+        + C     P P +TW +  +P  +  + S L  G  
Sbjct: 1464 LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRV 1523

Query: 473  LQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTAN----VS 528
            LQ   +  E+ G + C A+N V        L V+ T P   G     V   T N    VS
Sbjct: 1524 LQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL-TPPVILGDTEELVEEVTVNASSTVS 1582

Query: 529  WEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKL 588
             +    G    T S       F P     L V      L V T E   A  +  +A+N+ 
Sbjct: 1583 LQCPALGNPVPTISWLQNGLPFSPSP--RLQVLEDGQVLQVSTAEVADAASYMCVAENQA 1640

Query: 589  GTS 591
            G++
Sbjct: 1641 GSA 1643



 Score =  119 bits (298), Expect = 2e-26
 Identities = 126/479 (26%), Positives = 192/479 (40%), Gaps = 52/479 (10%)

Query: 31   EFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRA 90
            E VTA    SV L CDV       P P V  W+K    + +  +    P           
Sbjct: 1663 EQVTAILNSSVSLPCDV----HAHPNPEVT-WYKDSQALSLGEEVFLLP----------- 1706

Query: 91   SLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETP--PQ- 147
                  +L+L + R  D G Y C+ L          +   V L++  PP F + P  PQ 
Sbjct: 1707 ---GTHTLQLGRARLSDSGMYTCEALNA-----AGRDQKLVQLSVLVPPAFRQAPRGPQD 1758

Query: 148  YIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGS--LTVTSVSREDRGA 205
             +  + G    ++C     P+P VTW K+G  L  + + Q   G   L +      D+G 
Sbjct: 1759 AVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGL 1818

Query: 206  YTCRAYSIQGEAVHTTHLLVQGPPFIVSP-PENITVNISQDALLTCRAEAYPGNLTYTWY 264
            Y+C+  ++ GEAV T  L VQ PP   +P  E ++       +LTC     P   T TW 
Sbjct: 1819 YSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAP-TVTWL 1877

Query: 265  WQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
                 V       +   +   G L + R++P  +G YTCV  N+   +        +  P
Sbjct: 1878 KDRMPV---ESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAP 1934

Query: 325  -ARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTL---MEDG 380
              R   +    +V  G    + C  D +PP  V  W KDG PL   +++G  L   ++ G
Sbjct: 1935 RIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVA-WLKDGSPL--GQDMGPHLRFYLDGG 1991

Query: 381  SIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWE----YRQEAGR 436
            S+ ++       G YTCV +N  G   +     +++  PP  T+  G +         G 
Sbjct: 1992 SLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV--PP--TIKQGADGSGTLVSRPGE 2047

Query: 437  ELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGS---LQFRALSKEDHGEWECVATN 492
             + + C   G P   ++W K G P       L  GS   L+   +   D G + CVA +
Sbjct: 2048 LVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAAS 2106



 Score =  119 bits (297), Expect = 3e-26
 Identities = 140/576 (24%), Positives = 236/576 (40%), Gaps = 55/576 (9%)

Query: 33   VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
            V+  A ESV L C      +   PP V+ W+K G P+             +P      S 
Sbjct: 798  VSVVANESVALECQ-----SHAMPPPVLSWWKDGRPL-------------EPRPGVHLSA 839

Query: 93   HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAK 152
             DKA L++++    D G Y C+ L         H+    +L +   P F       +  +
Sbjct: 840  -DKALLQVDRADVWDAGHYTCEALN-----QAGHSEKHYNLNVWVAPVFPLRESHTLTVR 893

Query: 153  EGGSITMTCTAFGNPKPIVTWLKEGTLL---GASGKYQVSDGSLTVTSVSR-EDRGAYTC 208
            EG    ++C   G P P ++W K+G  L   GA  ++  + G L     ++    G YTC
Sbjct: 894  EGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTC 953

Query: 209  RAYSIQGEAVHTTHLLVQGPPFIVSPPENIT-VNISQD--ALLTCRAEAYPGNLTYTWYW 265
               ++ G +     L V  PP I  P E  T V++ QD  A L C A   P   T TW  
Sbjct: 954  ECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP-TVTWER 1012

Query: 266  QDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPA 325
              + V  +  L+L+ +     +L + R +   +G+Y+CV  N  GR+        +  P 
Sbjct: 1013 DGQPVGAELGLQLQNQ---GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPE 1069

Query: 326  RVLNMPPVIYVPVGIHGYIRCPVDA---EPPATVVKWNKDGRPLQVEKNLGWTLMEDGSI 382
             + ++ P+  +   +H  +    +A    PPA  ++W +   P+   ++  + L     +
Sbjct: 1070 LIGDLDPLTNITAALHSPLTLLCEAMGIPPPA--IRWFRGEEPVSPGEDT-YLLAGGWML 1126

Query: 383  RIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWE-YRQEAGRELLIP 441
            ++ +  E+  G Y+C+  N  G   ++    +++  PP        E  +   G+   + 
Sbjct: 1127 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLDGQTAHLM 1184

Query: 442  CAAAGDPFPVITWRKVGKP--SRSKHSALPSG-SLQFRALSKEDHGEWECVATNVVTSIT 498
            C   G P P +TW K G+P      H   P G  LQ    +    G + C+A N V   T
Sbjct: 1185 CNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKT 1244

Query: 499  ASTHLTVIGTSP----HAPGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFGPHD 554
                L+V+  +P     A  S   +V++T  N          +      WMK     P +
Sbjct: 1245 KHFQLSVL-LAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDG--APFE 1301

Query: 555  -WLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLG 589
               ++ + PG   L +   + E A Q++ +  N+LG
Sbjct: 1302 ASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1337



 Score =  116 bits (290), Expect = 2e-25
 Identities = 129/497 (25%), Positives = 186/497 (37%), Gaps = 44/497 (8%)

Query: 40   SVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLR 99
            SV L C      +G PPP V  WFK   P+                + G     D   LR
Sbjct: 620  SVTLEC----LASGVPPPDV-SWFKGHQPVS--------------SWMGVTVSVDGRVLR 660

Query: 100  LEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITM 159
            +EQ +  D G Y C    +    +  +      L +N PP  T  P           + +
Sbjct: 661  IEQAQLSDAGSYRCVASNVAGSTELRYG-----LRVNVPPRITLPPSLPGPVLVNTPVRL 715

Query: 160  TCTAFGNPKPIVTWLKEGTLLGASGK--YQVSDGS--LTVTSVSREDRGAYTCRAYSIQG 215
            TC A G P P + WLK+G  +  +G    QV  G   LT+ S    D G Y+C A S  G
Sbjct: 716  TCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG 775

Query: 216  EAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQND 275
            E      L V  PP I+    N++V  ++   L C++ A P  +  +W W+D       +
Sbjct: 776  EDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSW-WKDGRPL---E 830

Query: 276  LKLRVRILIDGTLI-IFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVI 334
             +  V +  D  L+ + R    D+G YTC   N  G S           P   L     +
Sbjct: 831  PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTL 890

Query: 335  YVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVE-KNLGWTLMEDGSIRIEEATEEALG 393
             V  G    + C      P   + W KDG+PL  E   L         + + +A     G
Sbjct: 891  TVREGHPTRLSCECRG-VPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEG 949

Query: 394  TYTCVPYNTLGTMGQSAPARLVLKDPPYFT--VLPGWEYRQEAGRELLIPCAAAGDPFPV 451
            TYTC   N +G   Q    +L +  PP       P  +          + C A G P P 
Sbjct: 950  TYTCECSNVVGNSSQD--LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT 1007

Query: 452  ITWRKVGKPSRSK---HSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGT 508
            +TW + G+P  ++          SL          G + CVA N+         L+V+  
Sbjct: 1008 VTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL-V 1066

Query: 509  SPHAPGSVRVQVSMTTA 525
             P   G +    ++T A
Sbjct: 1067 PPELIGDLDPLTNITAA 1083



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 148/588 (25%), Positives = 222/588 (37%), Gaps = 87/588 (14%)

Query: 53  GQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYE 112
           G P P +  WFK G  +P   K  Y          GR        L+L + +S D G Y 
Sbjct: 246 GVPTPNIT-WFKDGALLPTSTKVVY-------TRGGR-------QLQLGRAQSSDAGVYT 290

Query: 113 CKVLMLDQQYDTFHNGSWVHLTINAPPTFTETP--PQYIEAKEGGSITMTCTAFGNPKPI 170
           CK        +         L +  PPT       P  ++A  G  + + C A G+P P 
Sbjct: 291 CKASNAVGAAEKA-----TRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPT 345

Query: 171 VTWLKEGTLLGASGKYQV-SDGS-LTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGP 228
           ++W  EG  +  S + ++ +DGS L + S      G Y+C A S  GEAV    + VQ P
Sbjct: 346 LSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVP 405

Query: 229 P--FIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDG 286
           P   +      +T  + Q   L C+A   P   T  W    +N     +L   V++   G
Sbjct: 406 PQLLVAEGLGQVTTIVGQPLELPCQASGSPVP-TIQWL---QNGRPAEEL-AGVQVASQG 460

Query: 287 -TLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPV-----GI 340
            TL I  V+ + SG + C  +N  G     +A   V+        P V+ VP+     G 
Sbjct: 461 TTLHIDHVELDHSGLFACQATNEAG-----TAGAEVEVSVHGEWAPGVLEVPIGQYHWGX 515

Query: 341 HGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGS-----------------IR 383
             +   P   +PP     W    +P  VE   GW     GS                 ++
Sbjct: 516 EHHSSFPAACDPPVH-RGWGAHPKPPLVE---GW--CSPGSLWGEPTGIPVAYSLPPPLQ 569

Query: 384 IEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQE-AGRELLIPC 442
           IE+      G YTC   N  G   +    ++++  PP   + PG   +       + + C
Sbjct: 570 IEKVDLRDEGIYTCAATNLAGESKREVALKVLV--PP--NIEPGPVNKAVLENASVTLEC 625

Query: 443 AAAGDPFPVITWRKVGKPSRSKHSALPSGS---LQFRALSKEDHGEWECVATNVVTSITA 499
            A+G P P ++W K  +P  S      S     L+       D G + CVA+NV  S   
Sbjct: 626 LASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 685

Query: 500 STHLTV-----IGTSPHAPGSVRVQVSM-TTANVSWEPGYDGGYEQTFSVWMKRAQ-FGP 552
              L V     I   P  PG V V   +  T N +  P           +W+K      P
Sbjct: 686 RYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAP-------SPTLMWLKDGNPVSP 738

Query: 553 HDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVN 600
                L V PG   L + +     + ++S +A + +G      V+ V+
Sbjct: 739 AGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVH 786



 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 113/478 (23%), Positives = 182/478 (38%), Gaps = 49/478 (10%)

Query: 33  VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
           VT   G+ + L C      +G P P  ++W + G P                E AG    
Sbjct: 417 VTTIVGQPLELPCQA----SGSPVP-TIQWLQNGRPAE--------------ELAGVQVA 457

Query: 93  HDKASLRLEQVRSEDQGWYECKVL----MLDQQYDTFHNGSWVHLTINAPPTFTETPPQY 148
               +L ++ V  +  G + C+          + +   +G W    +  P        ++
Sbjct: 458 SQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEH 517

Query: 149 IEAKEGGSITMTCTAFG-NPKP--IVTWLKEGTLLGASGKYQVSDG---SLTVTSVSRED 202
             +            +G +PKP  +  W   G+L G      V+      L +  V   D
Sbjct: 518 HSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRD 577

Query: 203 RGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYT 262
            G YTC A ++ GE+     L V  PP I   P N  V  +    L C A   P     +
Sbjct: 578 EGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPP-DVS 636

Query: 263 WYWQDENVYFQNDLKLRVRILIDGTLI-IFRVKPEDSGKYTCVPSNSLGRSPSASAYLTV 321
           W+   + V       + V + +DG ++ I + +  D+G Y CV SN  G S      L V
Sbjct: 637 WFKGHQPV----SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG-STELRYGLRV 691

Query: 322 QYPARVLNMPPVIYVPVGIHGYIRCPVDAE-PPATVVKWNKDGRPLQVEKNLGWTLMEDG 380
             P R+  +PP +  PV ++  +R   +A   P+  + W KDG P+      G  +   G
Sbjct: 692 NVPPRI-TLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGG 750

Query: 381 SI-RIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQE--AGRE 437
            +  +  A     G Y+CV  + +G   Q    ++ +  PP    + G E      A   
Sbjct: 751 RVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHM--PP---SILGEELNVSVVANES 805

Query: 438 LLIPCAAAGDPFPVITWRKVGKPSRSK---HSALPSGSLQFRALSKEDHGEWECVATN 492
           + + C +   P PV++W K G+P   +   H +     LQ       D G + C A N
Sbjct: 806 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALN 863



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 95/382 (24%), Positives = 149/382 (39%), Gaps = 35/382 (9%)

Query: 138 PPTFTETPPQY-IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLG--------------- 181
           PP+  E   +  +    G S+T+ C A G P P + WLK+  L+G               
Sbjct: 16  PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 75

Query: 182 -ASGKYQVSDG-SLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIV--SPPEN 237
              G   + +G SL    +   D G Y+CRA +  G A    HLLV  PP ++     + 
Sbjct: 76  QVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQE 135

Query: 238 ITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLI-IFRVKPE 296
           +      D  L C     P       + +D          L+V+   DG ++ I      
Sbjct: 136 VLGLAGADVELQCWTSGVP--TPQVEWTKDRQPVLPGGPHLQVQ--EDGQVLRITGSHVG 191

Query: 297 DSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAE-PPAT 355
           D G+Y CV  +  G+  +    L V  P  +        V V     ++   +A   P  
Sbjct: 192 DEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP 250

Query: 356 VVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLV 415
            + W KDG  L     + +T      +++  A     G YTC   N +G   ++   RL 
Sbjct: 251 NITWFKDGALLPTSTKVVYT-RGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKA--TRLD 307

Query: 416 LKDPPYFTVLPGWEY--RQEAGRELLIPCAAAGDPFPVITWRKVGKP-SRSKHSALPSGS 472
           +  PP      G  Y  +  AGR + + C A G P P ++W   G P + S  S L +  
Sbjct: 308 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDG 367

Query: 473 --LQFRALSKEDHGEWECVATN 492
             L+  +  +   G + CVA++
Sbjct: 368 SVLRLESPGEASSGLYSCVASS 389


>gi|157311649 neogenin homolog 1 [Homo sapiens]
          Length = 1461

 Score =  149 bits (375), Expect = 2e-35
 Identities = 149/564 (26%), Positives = 228/564 (40%), Gaps = 48/564 (8%)

Query: 154 GGSITMTCTAFGNPKPIVTWLKEGTLLGASG---KYQVSDGSLTVTSV-----SREDRGA 205
           G S+ + C+A+  P P + W K+GT L       +  + DGSL +++V     ++ D G 
Sbjct: 67  GSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGY 126

Query: 206 YTCRAY--SIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTW 263
           Y C A   S+      T  L+V G P   S PE  +V    +A+L C   A    + +  
Sbjct: 127 YQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNA--DLVPFVR 184

Query: 264 YWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQY 323
           + Q+      +D   RV  L  G L+I      D G Y CV  +      S    L V  
Sbjct: 185 WEQNRQPLLLDD---RVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLP 241

Query: 324 PARV------LNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLM 377
              V      L  P  +   +G    + C     P  T+ KW K+   L  E +    L+
Sbjct: 242 DPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTI-KWMKNEEALDTESSERLVLL 300

Query: 378 EDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRE 437
             GS+ I + TE+  GTY C+  N  G     A A L ++  P F   P   Y  E+  +
Sbjct: 301 AGGSLEISDVTEDDAGTYFCIADN--GNETIEAQAELTVQAQPEFLKQPTNIYAHES-MD 357

Query: 438 LLIPCAAAGDPFPVITWRKVGK---PSRSKHSALPSGSLQFRALSKEDHGEWECVATNVV 494
           ++  C   G P P + W K G    PS      +   +LQ   L K D G ++C+A N V
Sbjct: 358 IVFECEVTGKPTPTVKWVKNGDMVIPS-DYFKIVKEHNLQVLGLVKSDEGFYQCIAENDV 416

Query: 495 TSITASTHLTVI-------GTSPHAPGSVRVQ-VSMTTANVSWE-PGYD-GGYEQTFSVW 544
            +  A   L ++       G  P AP  V    VS     ++W  P  D  G   T+SV+
Sbjct: 417 GNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVF 476

Query: 545 MKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAF 604
             +      + +     PG   + +  L P T Y F V+AQNK G+   S  + V     
Sbjct: 477 YTKEGIA-RERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVE---- 531

Query: 605 PITTPEPLVLVTPPRCLIANRTQQGVLLSWLPPANHSFPIDRYIMEFRVAERWELLDDGI 664
             T PE  +    P       +   + ++W  P + +  I  Y + +   E+    +  +
Sbjct: 532 --TQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYY--MEKGTDKEQDV 587

Query: 665 PGTEGEFFAKDLSQDTWYEFRVLA 688
             +   +    L + T Y FRV+A
Sbjct: 588 DVSSHSYTINGLKKYTEYSFRVVA 611



 Score =  109 bits (273), Expect = 2e-23
 Identities = 176/762 (23%), Positives = 289/762 (37%), Gaps = 122/762 (16%)

Query: 29  EPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAG 88
           EP    +  G SV+L C        +P P + EW K G  + +                 
Sbjct: 58  EPVDTLSVRGSSVILNCSAY----SEPSPKI-EWKKDGTFLNLVSD-------------D 99

Query: 89  RASLHDKASLRLEQV-----RSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTE 143
           R  L    SL +  V        D+G+Y+C   +  +   T  + +   L +   P FT 
Sbjct: 100 RRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATV--ESLGTIISRT-AKLIVAGLPRFTS 156

Query: 144 TP-PQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGT-LLGASGKYQVSDGSLTVTSVSRE 201
            P P  + A  G +  + C    +  P V W +    LL      ++  G L +++ +  
Sbjct: 157 QPEPSSVYA--GNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEG 214

Query: 202 DRGAYTCRAYSIQGEAVHT--THLLVQGPPFIVSP------PENITVNISQDALLTCRAE 253
           D G Y C   S  G   ++    L V   P ++S       P  +   I QD +L C A 
Sbjct: 215 DGGLYRCVVES-GGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVAS 273

Query: 254 AYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSP 313
             P   T T  W         +   R+ +L  G+L I  V  +D+G Y C+  N    + 
Sbjct: 274 GLP---TPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNG-NETI 329

Query: 314 SASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLG 373
            A A LTVQ     L  P  IY    +     C V  +P  TV KW K+G    V  +  
Sbjct: 330 EAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTV-KWVKNGD--MVIPSDY 386

Query: 374 WTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFT-VLPGWEYRQ 432
           + ++++ ++++    +   G Y C+  N +G   Q+    ++L+  P  T  LP      
Sbjct: 387 FKIVKEHNLQVLGLVKSDEGFYQCIAENDVGN-AQAGAQLIILEHAPATTGPLPS----- 440

Query: 433 EAGRELLIPCAAAGDPFPVITWRKV-------------------------------GKPS 461
            A R+++   +     F  +TWR                                 G+  
Sbjct: 441 -APRDVV--ASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ 497

Query: 462 RSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVS 521
            +  + +P+    FR +++  HG  E  A      +   T   V    P AP       S
Sbjct: 498 VTIQNLMPATVYIFRVMAQNKHGSGESSAP-----LRVETQPEVQLPGP-APNLRAYAAS 551

Query: 522 MTTANVSWEPGYDGGYE-QTFSVW-MKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQ 579
            T+  V+WE    G  E Q + ++ M++      D     V        ++ L+  T Y 
Sbjct: 552 PTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQD-----VDVSSHSYTINGLKKYTEYS 606

Query: 580 FSVLAQNKLGTSAFSEVVTVNTLA-FPITTPEPLVLVTPPRCLIANRTQQGVLLSWLP-- 636
           F V+A NK G    +  V V TL+  P   P+ L L          R  + +++ W P  
Sbjct: 607 FRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEV--------RNSKSIMIHWQPPA 658

Query: 637 PANHSFPIDRYIMEFRVAER-WELLDDGIPGTEGEFFAKDLSQDTWYEFRVLAV------ 689
           PA  +  I  Y + +R A R  ++ +  + GT+     + L + T Y FRV A+      
Sbjct: 659 PATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTG 718

Query: 690 -MQDLISEPSNIAGVSSTDIFPQPDLTEDGLARPVLAGIVAT 730
              D +S  +  + +  T +   P++      RP++  IV +
Sbjct: 719 PATDWLSAETFESDLDETRV---PEVPSSLHVRPLVTSIVVS 757



 Score = 77.8 bits (190), Expect = 7e-14
 Identities = 157/736 (21%), Positives = 270/736 (36%), Gaps = 133/736 (18%)

Query: 28  EEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYA 87
           ++P  +    G+ VVL C      +G P P  ++W K                 +D E +
Sbjct: 253 KQPSPLVRVIGQDVVLPC----VASGLPTP-TIKWMK-------------NEEALDTESS 294

Query: 88  GRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQ 147
            R  L    SL +  V  +D G Y C   + D   +T    +   LT+ A P F + P  
Sbjct: 295 ERLVLLAGGSLEISDVTEDDAGTYFC---IADNGNETIE--AQAELTVQAQPEFLKQPTN 349

Query: 148 YIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQ-VSDGSLTVTSVSREDRGAY 206
            I A E   I   C   G P P V W+K G ++  S  ++ V + +L V  + + D G Y
Sbjct: 350 -IYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFY 408

Query: 207 TCRAYSIQGEAVHTTHLLV-------QGPPFIVSPPENITVNISQDALL-----TCRAEA 254
            C A +  G A     L++        GP  + S P ++  ++     +     T  ++ 
Sbjct: 409 QCIAENDVGNAQAGAQLIILEHAPATTGP--LPSAPRDVVASLVSTRFIKLTWRTPASDP 466

Query: 255 YPGNLTYTWYW--------QDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPS 306
           +  NLTY+ ++        + EN     ++++ ++ L+  T+ IFRV  ++         
Sbjct: 467 HGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQN--------K 518

Query: 307 NSLGRSPSASAYLT---VQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDG 363
           +  G S +     T   VQ P    N+      P  I      PV         K     
Sbjct: 519 HGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYME 578

Query: 364 RPLQVEKNL----------GWTLMEDGSIRIEEATEEALGTYT-CVPYNTLGTMGQSAPA 412
           +    E+++          G     + S R+    +   G  T  V   TL  +  +AP 
Sbjct: 579 KGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQ 638

Query: 413 RLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGS 472
            L L+     +++  W+    A +   I           I +RK  + S      L SG+
Sbjct: 639 NLSLEVRNSKSIMIHWQPPAPATQNGQITGYK-------IRYRKASRKS-DVTETLVSGT 690

Query: 473 LQFRALSKEDHG-EWEC-VATNVVTSITASTHLTVIGT---------SPHAPGSVRVQVS 521
              + +   D G E+   VA   +     +T      T          P  P S+ V+  
Sbjct: 691 QLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPL 750

Query: 522 MTTANVSWEPGYD-----GGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPET 576
           +T+  VSW P  +      GY   + +    AQ       ++ V     +  ++ L+P +
Sbjct: 751 VTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQ-------TIKVDYKQRYYTIENLDPSS 803

Query: 577 AYQFSVLAQNKLGTS--AFSEVVT-------------VNTLAFPITTPEPLVLVTPPRCL 621
            Y  ++ A N +G     +   VT             +N    P+  P+P  ++ P    
Sbjct: 804 HYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPV--PDPTPMMPPVGVQ 861

Query: 622 IANRTQQGVLLSWLPPANHSFPIDRYIMEFR-VAERWELLDDGIP---------GTEGEF 671
            +  +   + ++W   A++S P  + I + R    RW+     IP          T   +
Sbjct: 862 ASILSHDTIRITW---ADNSLPKHQKITDSRYYTVRWK---TNIPANTKYKNANATTLSY 915

Query: 672 FAKDLSQDTWYEFRVL 687
               L  +T YEF V+
Sbjct: 916 LVTGLKPNTLYEFSVM 931



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 41/128 (32%), Positives = 59/128 (46%), Gaps = 16/128 (12%)

Query: 404 GTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGK---- 459
           G+  QS  A +    P YF V P  +     G  +++ C+A  +P P I W+K G     
Sbjct: 37  GSAPQSPGASIRTFTPFYFLVEPV-DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNL 95

Query: 460 PSRSKHSALPSGSLQFRAL-----SKEDHGEWECVAT--NVVTSITASTHLTVIG----T 508
            S  +   LP GSL    +     +K D G ++CVAT  ++ T I+ +  L V G    T
Sbjct: 96  VSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFT 155

Query: 509 SPHAPGSV 516
           S   P SV
Sbjct: 156 SQPEPSSV 163



 Score = 38.5 bits (88), Expect = 0.044
 Identities = 31/124 (25%), Positives = 55/124 (44%), Gaps = 8/124 (6%)

Query: 568  LVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEPLVLVTPPRCLIANRTQ 627
            LV  L+P T Y+FSV+      +S +S      T     T+P   V V     +      
Sbjct: 916  LVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTV-----VSKEGKP 970

Query: 628  QGVLLSWLPPANHSFPIDRYIMEFRVAERWELLD---DGIPGTEGEFFAKDLSQDTWYEF 684
            + ++++W PP+  +  I  YI+ +      E+ D   + + G       ++L+ DT Y F
Sbjct: 971  KTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYF 1030

Query: 685  RVLA 688
            ++ A
Sbjct: 1031 KIQA 1034



 Score = 31.6 bits (70), Expect = 5.4
 Identities = 31/112 (27%), Positives = 45/112 (40%), Gaps = 8/112 (7%)

Query: 496  SITA-STHLTVIGTSPHAPGSVRV---QVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFG 551
            S+TA  T   ++ TSP  P  V V   +    T  V+W+P  +   + T  +        
Sbjct: 942  SMTAHGTTFELVPTSP--PKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVN 999

Query: 552  P--HDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNT 601
               HDW+  PV        +  L  +T Y F + A+N  G    SE V   T
Sbjct: 1000 AEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRT 1051


>gi|81158224 neuronal cell adhesion molecule isoform B precursor
           [Homo sapiens]
          Length = 1183

 Score =  146 bits (368), Expect = 2e-34
 Identities = 152/597 (25%), Positives = 244/597 (40%), Gaps = 49/597 (8%)

Query: 27  REEPEFVTARAGESVVLRCDVIHPVTGQPPPYVV------------EWFKFGVPIPIFIK 74
           +E+ E +T ++G+S+VL C    P  G PPP +             E    G+   ++  
Sbjct: 143 KEKLEPITLQSGQSLVLPC---RPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFS 199

Query: 75  FGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGS----- 129
               P     +Y   A  +   +++ +Q  S        KV+ +D+  DT          
Sbjct: 200 -NVLPEDTREDYICYARFNHTQTIQQKQPIS-------VKVISVDELNDTIAANLSDTEF 251

Query: 130 -WVHLTINAPPTFTETPPQYIEAKE---GGSITMTCTAFGNPKPIVTWLKEGTLLGASGK 185
                +   PPTF  TP      KE   G  +++ C A G P PI+ W KE  +L  +  
Sbjct: 252 YGAKSSRERPPTFL-TPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRT 310

Query: 186 -YQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQ 244
            Y+  + +L +  VS  D G Y C A +  G   HT  + V+  P+ ++ P+N+ ++  +
Sbjct: 311 VYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGE 370

Query: 245 DALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIF-RVKPEDSGKYTC 303
           D  L CRA   P     +W      +    D   R    IDG  IIF  V+   S  Y C
Sbjct: 371 DGTLICRANGNP-KPRISWLTNGVPIEIAPDDPSR---KIDGDTIIFSNVQERSSAVYQC 426

Query: 304 VPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDG 363
             SN  G   + +    +  P R+L     +Y  +     +        P   ++W K  
Sbjct: 427 NASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGA 486

Query: 364 RPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFT 423
           +   + +++ + L E+G++ I  A +++ GTYTCV  N LG         L +KDP +  
Sbjct: 487 KGSALHEDI-YVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNE--VHLEIKDPTWIV 543

Query: 424 VLPGWEYRQEAGRELLIPCAAAGDPFPVIT--WRKVGKPSRS-KHSALPSGSLQFRALSK 480
             P +   Q  G  +   C    D    +T  W K  +   S +   +    L    +S 
Sbjct: 544 KQPEYAVVQR-GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSD 602

Query: 481 EDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSM-TTANVSWEPGYDGGYEQ 539
           +D G + CVA   + S++AS  L+V+   P+ P  + +   +  +  +SW PG D     
Sbjct: 603 DDSGTYTCVANTTLDSVSASAVLSVVDV-PNPPFDLELTDQLDKSVQLSWTPGDDNNSPI 661

Query: 540 T-FSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSE 595
           T F +  + A   P  W       G        L P   Y F V+A N +G S  SE
Sbjct: 662 TKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSE 718



 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 185/802 (23%), Positives = 285/802 (35%), Gaps = 148/802 (18%)

Query: 30   PEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGR 89
            P+ +    GE   L C       G P P +  W   GVPI I            P+   R
Sbjct: 361  PQNLVLSPGEDGTLICRA----NGNPKPRI-SWLTNGVPIEIA-----------PDDPSR 404

Query: 90   ASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYI 149
                D  ++    V+      Y+C       +Y      ++V++    P   T     Y 
Sbjct: 405  KI--DGDTIIFSNVQERSSAVYQCNA---SNEYGYLLANAFVNVLAEPPRILTPANTLY- 458

Query: 150  EAKEGGSITMTCTAFGNPKPIVTWLK--EGTLLGASGKYQVSDGSLTVTSVSREDRGAYT 207
            +        + C  FG+P P + W K  +G+ L         +G+L +    ++  G YT
Sbjct: 459  QVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYT 518

Query: 208  CRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQD 267
            C A +  G A +  HL ++ P +IV  PE   V         C+ + +   L+ T  W  
Sbjct: 519  CVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVK-HDHTLSLTVLWLK 577

Query: 268  ENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARV 327
            +N    +D +  V       L++  V  +DSG YTCV + +L  S SASA L+V      
Sbjct: 578  DNRELPSDERFTVD---KDHLVVADVSDDDSGTYTCVANTTLD-SVSASAVLSV------ 627

Query: 328  LNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGS------ 381
                  + VP              PP  +   ++  + +Q    L WT  +D +      
Sbjct: 628  ------VDVP-------------NPPFDLELTDQLDKSVQ----LSWTPGDDNNSPITKF 664

Query: 382  -IRIEEATE---------EALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYR 431
             I  E+A           E  GT T         +  S     V             +Y 
Sbjct: 665  IIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYL 724

Query: 432  QEAGRELLIPCAAAG---DPFP-VITWRKVGKPSRSKHSALPSGSLQFRALSKEDHGEW- 486
             +A      P A  G   +P   VITW    KP     S  P    +     K+   EW 
Sbjct: 725  TKASEPDKNPTAVEGLGSEPDNLVITW----KPLNGFESNGPGLQYKVSWRQKDGDDEWT 780

Query: 487  ECVATNVVTSITASTHLTV-----------IGTSPH---------------APGSVRVQV 520
              V  NV   I + T   V           +G +P                APG+VRV V
Sbjct: 781  SVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNV 840

Query: 521  -SMTTANVSWEP---GYDGGYEQTFSVWMKRAQFGPH------DWLSLPVPPGPSWLLVD 570
             + T A V W+P       G+ Q + ++  + Q          +   L      +  ++ 
Sbjct: 841  VNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLP 900

Query: 571  TLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEPLVLVTPPRCLIANRTQQGV 630
             LEP + Y  +V   N  G    S     NT     + P  L +V P        T   +
Sbjct: 901  GLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNP--------TLDSL 952

Query: 631  LLSWLPPANHSFPIDRYIMEFR----VAERWELLDDGIPGTEGEFFAKDLSQDTWYEFRV 686
             L W PP++ +  +  Y ++++      E   L+D  IP  +  +  K+L+  T Y+F  
Sbjct: 953  TLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYF 1012

Query: 687  LAVMQDLISEPSNIAGVSSTDI-----FPQPDLTEDGLARPVLAGIVATICFLAAAILFS 741
             A  Q      S I   + T +       Q D+   G         +  +C +A  IL  
Sbjct: 1013 YA--QTSAGSGSQITEEAVTTVDEAMASRQVDIATQG-------WFIGLMCAVALLILI- 1062

Query: 742  TLAACFV--NKQRKRKLKRKKD 761
             L  CF+  NK  K  +K K+D
Sbjct: 1063 LLIVCFIRRNKGGKYPVKEKED 1084



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 120/573 (20%), Positives = 213/573 (37%), Gaps = 69/573 (12%)

Query: 131 VHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVS- 189
           V L +  PPT T+  P+        +I + C A G P P  +W + GT         V+ 
Sbjct: 32  VPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTM 91

Query: 190 ---DGSLTVTSVSRED----RGAYTCRAYSIQGEAVHTTHLL--VQGPPFIVSPPENITV 240
               G+L +  +S        G Y C A + +G AV    ++   + P +     E IT+
Sbjct: 92  KPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITL 151

Query: 241 NISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGK 300
              Q  +L CR     G      +W D N + +     RV   ++G L    V PED+ +
Sbjct: 152 QSGQSLVLPCRPPI--GLPPPIIFWMD-NSFQRLPQSERVSQGLNGDLYFSNVLPEDTRE 208

Query: 301 -YTC--------------------VPSNSLGRSPSASAYLTVQYPAR-VLNMPPVIYVPV 338
            Y C                    +  + L  + +A+   T  Y A+     PP    P 
Sbjct: 209 DYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPE 268

Query: 339 G-------IHGYI---RCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEAT 388
           G       + G +    C  +  P   +    +DG    + KN       + +++I   +
Sbjct: 269 GNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDG---MLPKNRTVYKNFEKTLQIIHVS 325

Query: 389 EEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDP 448
           E   G Y C+  N LG +  +   R  +K  PY+   P        G +  + C A G+P
Sbjct: 326 EADSGNYQCIAKNALGAIHHTISVR--VKAAPYWITAP-QNLVLSPGEDGTLICRANGNP 382

Query: 449 FPVITWRKVGKPSR----SKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLT 504
            P I+W   G P           +   ++ F  + +     ++C A+N    + A+  + 
Sbjct: 383 KPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVN 442

Query: 505 VIGTSPH--APGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPP 562
           V+   P    P +   QV +       +  + G    T   W K A+ G      + V  
Sbjct: 443 VLAEPPRILTPANTLYQV-IANRPALLDCAFFGSPLPTIE-WFKGAK-GSALHEDIYVLH 499

Query: 563 GPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEPLVL----VTPP 618
               L +   + ++   ++ +A+NKLG +     + +    + +  PE  V+    +   
Sbjct: 500 ENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSF 559

Query: 619 RCLIANRTQQGVLLSWLP-----PANHSFPIDR 646
            C + +     + + WL      P++  F +D+
Sbjct: 560 ECKVKHDHTLSLTVLWLKDNRELPSDERFTVDK 592


>gi|75709184 contactin 3 [Homo sapiens]
          Length = 1028

 Score =  144 bits (364), Expect = 4e-34
 Identities = 148/584 (25%), Positives = 236/584 (40%), Gaps = 60/584 (10%)

Query: 33  VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
           V+ R G+ VVL C         PPP+  E     +       F  YP  V+ E + R   
Sbjct: 132 VSVREGQGVVLLCG--------PPPHSGELSYAWI-------FNEYPSFVE-EDSRRFVS 175

Query: 93  HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQY---- 148
            +   L + +V   D G Y C V  +         GS   L + +     E  P+     
Sbjct: 176 QETGHLYISKVEPSDVGNYTCVVTSMVTNARVL--GSPTPLVLRSDGVMGEYEPKIEVQF 233

Query: 149 ---IEAKEGGSITMTCTAFGNPKPIVTWLK-EGTLLGASGKYQVSDGSLTVTSVSREDRG 204
              + A +G ++ + C A GNP P + W + +G    +  K +   G L + +  +ED G
Sbjct: 234 PETLPAAKGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAG 293

Query: 205 AYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWY 264
           +Y C A + +G+ V    L     P  V   +++ + +       CRA   P   +Y W 
Sbjct: 294 SYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKP-KPSYRWL 352

Query: 265 WQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
                +  +   ++      +G L I  +   DSG + C+  N  G   S SA L V   
Sbjct: 353 KNGAALVLEERTQIE-----NGALTISNLSVTDSGMFQCIAENKHGLVYS-SAELKVVAS 406

Query: 325 ARVLNMPPV---IYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGS 381
           A   +  P+   + V VG    + C   A P A +  W K    +Q  + +  +L+ DG 
Sbjct: 407 APDFSKNPMKKLVQVQVGSLVSLDCKPRASPRA-LSSWKKGDVSVQEHERI--SLLNDGG 463

Query: 382 IRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIP 441
           ++I   T+   GTYTC+  N  G    +    LV+ +P   T+ P        G  +++P
Sbjct: 464 LKIANVTKADAGTYTCMAENQFGKA--NGTTHLVVTEPTRITLAPS-NMDVSVGESVILP 520

Query: 442 CAAAGDPFP--VITWRKVGKPSRSKHSAL--------PSGSLQFRALSKEDHGEWECVAT 491
           C    DP    + TW   G  +  K             SG L  R +  +  G++ C+  
Sbjct: 521 CQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQ 580

Query: 492 NVVTSITASTHLTVIGTSPHAPGSVRV-QVSMTTANVSWEPGYDGGYEQTFSVWMKRAQF 550
             V S++++  L V G SP  P +V+V +++ TTA +SW+ G D            R  F
Sbjct: 581 TGVDSVSSAADLIVRG-SPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPF 639

Query: 551 GPHDWLSLPVPPG-----PSWLLVDTLEPETAYQFSVLAQNKLG 589
               W ++   P           V  L P   Y+F V+A NK+G
Sbjct: 640 SV-GWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIG 682



 Score =  102 bits (254), Expect = 2e-21
 Identities = 125/503 (24%), Positives = 194/503 (38%), Gaps = 69/503 (13%)

Query: 30  PEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGR 89
           PE + A  G +V L C  +    G P P +      G+P    IK   +           
Sbjct: 234 PETLPAAKGSTVKLECFAL----GNPIPQINWRRSDGLPFSSKIKLRKF----------- 278

Query: 90  ASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYI 149
                   L +   + ED G YEC       +     N +   LT  A P + +     +
Sbjct: 279 -----SGVLEIPNFQQEDAGSYECIA-----ENSRGKNVARGRLTYYAKPHWVQLIKD-V 327

Query: 150 EAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSREDRGAYTCR 209
           E     S+   C A G PKP   WLK G  L    + Q+ +G+LT++++S  D G + C 
Sbjct: 328 EIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQIENGALTISNLSVTDSGMFQCI 387

Query: 210 AYSIQGEAVHTTHLLV--QGPPFIVSPPEN-ITVNISQDALLTCRAEAYPGNLTYTWYWQ 266
           A +  G    +  L V    P F  +P +  + V +     L C+  A P  L+    W+
Sbjct: 388 AENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALS---SWK 444

Query: 267 DENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPAR 326
             +V  Q     R+ +L DG L I  V   D+G YTC+  N  G++ + + +L V  P R
Sbjct: 445 KGDVSVQE--HERISLLNDGGLKIANVTKADAGTYTCMAENQFGKA-NGTTHLVVTEPTR 501

Query: 327 VLNMPPVIYVPVGIHGYIRCPVDAEPPATVV-KWNKDGRPLQVEKN------LGWTLMED 379
           +   P  + V VG    + C V  +P   ++  W  +G     +K+      +G +    
Sbjct: 502 ITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGS--SS 559

Query: 380 GSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELL 439
           G + I     +  G Y C+     G    S+ A L+++  P              G    
Sbjct: 560 GDLMIRNIQLKHSGKYVCMVQT--GVDSVSSAADLIVRGSP--------------GPPEN 603

Query: 440 IPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITA 499
           +      D    ++W    K  +  HS + S S+Q R         W+ V T V   I  
Sbjct: 604 VKVDEITDTTAQLSW----KEGKDNHSPVISYSIQARTPFSVG---WQTV-TTVPEVIDG 655

Query: 500 STH-LTVIGTSPHAPGSVRVQVS 521
            TH  TV+  +P      RV  S
Sbjct: 656 KTHTATVVELNPWVEYEFRVVAS 678



 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 101/403 (25%), Positives = 160/403 (39%), Gaps = 51/403 (12%)

Query: 139 PTFTETPPQYI--EAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGAS--GKYQVSDGSLT 194
           P F + P   I     E   IT+ C A GNP P   W   G+ +  S   +Y+++ G+L 
Sbjct: 26  PVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLV 85

Query: 195 VTSVSRE-DRGAYTCRAYSIQGEAVHTTHLL--VQGPPFIVSPPENITVNISQDALLTCR 251
           V + +R  D G Y C A +  G  V     L       F       ++V   Q  +L C 
Sbjct: 86  VINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLCG 145

Query: 252 AEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGR 311
              + G L+Y W + +   + + D + R      G L I +V+P D G YTCV ++ +  
Sbjct: 146 PPPHSGELSYAWIFNEYPSFVEEDSR-RFVSQETGHLYISKVEPSDVGNYTCVVTSMVTN 204

Query: 312 SPSASAYLTVQYPARVLNMP-PVIYVPVGIHGYIRCPVDAEPPATV-------------- 356
                        ARVL  P P++    G+ G     ++ + P T+              
Sbjct: 205 -------------ARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFA 251

Query: 357 -------VKWNK-DGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQ 408
                  + W + DG P   +  L       G + I    +E  G+Y C+  N+ G    
Sbjct: 252 LGNPIPQINWRRSDGLPFSSKIKL---RKFSGVLEIPNFQQEDAGSYECIAENSRGK--N 306

Query: 409 SAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKP-SRSKHSA 467
            A  RL     P++  L   +        L   C A+G P P   W K G      + + 
Sbjct: 307 VARGRLTYYAKPHWVQLIK-DVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQ 365

Query: 468 LPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSP 510
           + +G+L    LS  D G ++C+A N    + +S  L V+ ++P
Sbjct: 366 IENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAP 408



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 97/382 (25%), Positives = 148/382 (38%), Gaps = 24/382 (6%)

Query: 223 LLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRI 282
           LL+QGP FI  P  +I    S+D  +T   EA  GN +  + WQ         ++ R ++
Sbjct: 21  LLLQGPVFIKEPSNSIFPVGSEDKKITLHCEAR-GNPSPHYRWQLNGSDIDMSMEHRYKL 79

Query: 283 LIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARV-LNMPPVIYVPVGIH 341
                ++I   +  D+G Y C  +NSLG   S  A L   Y       M   + V  G  
Sbjct: 80  NGGNLVVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQG 139

Query: 342 GYIRCPVDAEPPATVVKWNKDGRPLQVEK-NLGWTLMEDGSIRIEEATEEALGTYTCVPY 400
             + C            W  +  P  VE+ +  +   E G + I +     +G YTCV  
Sbjct: 140 VVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVT 199

Query: 401 NTL-GTMGQSAPARLVLKDPPYFTVLPGWEYRQEA----------GRELLIPCAAAGDPF 449
           + +       +P  LVL+      V+  +E + E           G  + + C A G+P 
Sbjct: 200 SMVTNARVLGSPTPLVLRSD---GVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPI 256

Query: 450 PVITWRKV-GKPSRSKHSALP-SGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIG 507
           P I WR+  G P  SK      SG L+     +ED G +EC+A N      A   LT   
Sbjct: 257 PQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYY- 315

Query: 508 TSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWL 567
             PH    ++        ++ WE    G  + ++  W+K    G    L          L
Sbjct: 316 AKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYR-WLKN---GAALVLEERTQIENGAL 371

Query: 568 LVDTLEPETAYQFSVLAQNKLG 589
            +  L    +  F  +A+NK G
Sbjct: 372 TISNLSVTDSGMFQCIAENKHG 393


>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
          Length = 1026

 Score =  144 bits (363), Expect = 6e-34
 Identities = 162/628 (25%), Positives = 251/628 (39%), Gaps = 65/628 (10%)

Query: 33  VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
           V+ R G+ +VL C         PPP+  E     +       F  YP + D     R   
Sbjct: 132 VSVRRGQGMVLLCG--------PPPHSGELSYAWI-------FNEYPSYQDNR---RFVS 173

Query: 93  HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINA-----PPTFTETPPQ 147
            +  +L + +V   D G Y C V      +      + + L  +       P      P+
Sbjct: 174 QETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPE 233

Query: 148 YIEAKEGGSITMTCTAFGNPKPIVTWLK-EGTLLGASGKYQVSDGSLTVTSVSREDRGAY 206
            +   +G ++ + C A GNP P + W + +G  +    +   S+G L + +  +ED G Y
Sbjct: 234 TVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLY 293

Query: 207 TCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQ 266
            C A + +G+ V    L     P  +    +I V + ++    C+A   P   TY W   
Sbjct: 294 ECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRP-KPTYKWLKN 352

Query: 267 DENVYFQNDLKLRVRILID-GTLIIFRVKPEDSGKYTCVPSNSLGR--SPSASAYLTVQY 323
            E       L  R RI I+ GTL I  V   D+G Y C+  N  G   S +  + + V  
Sbjct: 353 GE------PLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGP 406

Query: 324 PARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIR 383
                 +  V  V VG    I C   A P   V  W K GR + +++N   T+ EDG++R
Sbjct: 407 DFSRTLLKRVTLVKVGGEVVIECKPKASPKP-VYTWKK-GRDI-LKENERITISEDGNLR 463

Query: 384 IEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCA 443
           I   T+   G+YTC+  N  GT   S+   LV+KDP    V P        G  +++PC 
Sbjct: 464 IINVTKSDAGSYTCIATNHFGTA--SSTGNLVVKDPTRVMVPPS-SMDVTVGESIVLPCQ 520

Query: 444 AAGDPFP--VITWR---------KVGKPSRSKHSALPSGSLQFRALSKEDHGEWECVATN 492
              D     V TW          + G           +G L  R +  +  G++ C+   
Sbjct: 521 VTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQT 580

Query: 493 VVTSITASTHLTVIGTSPHAPGSVRV-QVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFG 551
            V  ++A+  L V G  P  P +V + +++ TTA +SW PG D     T  V   R  F 
Sbjct: 581 SVDRLSAAADLIVRGP-PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFS 639

Query: 552 PHDWLSLPVPP----GPSW-LLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPI 606
              W ++   P    G ++   V  L P   Y+F  +A N +G    S            
Sbjct: 640 V-GWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKR------ 692

Query: 607 TTPEPLVLVTPPRCLIANRTQQGVLLSW 634
            T E L  VTP        ++  ++++W
Sbjct: 693 RTEEALPEVTPANVSGGGGSKSELVITW 720



 Score =  108 bits (270), Expect = 3e-23
 Identities = 125/493 (25%), Positives = 197/493 (39%), Gaps = 70/493 (14%)

Query: 30  PEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGR 89
           PE V    G +V L C  +    G P P ++     G PI                 A +
Sbjct: 232 PETVPTAKGATVKLECFAL----GNPVPTIIWRRADGKPI-----------------ARK 270

Query: 90  ASLH-DKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQY 148
           A  H     L +   + ED G YEC       +     N +   LT  A P + +     
Sbjct: 271 ARRHKSNGILEIPNFQQEDAGLYECVA-----ENSRGKNVARGQLTFYAQPNWIQKINDI 325

Query: 149 IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSREDRGAYTC 208
             A E  ++   C A G PKP   WLK G  L    + Q+  G+L +T V+  D G Y C
Sbjct: 326 HVAMEE-NVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQC 384

Query: 209 RAYSIQGEAVHTTHL--LVQGPPFIVSPPENIT-VNISQDALLTCRAEAYPGNLTYTWYW 265
            A +  G       L  +  GP F  +  + +T V +  + ++ C+ +A P    YTW  
Sbjct: 385 LAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASP-KPVYTWK- 442

Query: 266 QDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPA 325
           +  ++  +N+   R+ I  DG L I  V   D+G YTC+ +N  G + S++  L V+ P 
Sbjct: 443 KGRDILKENE---RITISEDGNLRIINVTKSDAGSYTCIATNHFG-TASSTGNLVVKDPT 498

Query: 326 RVLNMPPVIYVPVGIHGYIRCPVDAEPPATVV-KWNKDGRPLQVEKN------LGWTLME 378
           RV+  P  + V VG    + C V  +    +V  W+ +G  +  +++      +G     
Sbjct: 499 RVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQ-DS 557

Query: 379 DGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGREL 438
            G + I     +  G Y C+   ++  +  SA A L+++ PP              G   
Sbjct: 558 AGDLMIRNIQLKHAGKYVCMVQTSVDRL--SAAADLIVRGPP--------------GPPE 601

Query: 439 LIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSIT 498
            +      D    ++WR    P    HS +    +Q R         W+ V+T V   I 
Sbjct: 602 AVTIDEITDTTAQLSWR----PGPDNHSPITMYVIQARTPFSVG---WQAVST-VPELID 653

Query: 499 ASTH-LTVIGTSP 510
             T   TV+G +P
Sbjct: 654 GKTFTATVVGLNP 666



 Score =  100 bits (250), Expect = 7e-21
 Identities = 96/399 (24%), Positives = 156/399 (39%), Gaps = 36/399 (9%)

Query: 134 TINAPPTFTE-TPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLL--GASGKYQVSD 190
           T++ P    E +P  +    E   + + C   GNPKP + W   GT +  G   +Y V +
Sbjct: 22  TLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVE 81

Query: 191 GSLTVTSVSR-EDRGAYTCRAYSIQGEAVHTTHLL--VQGPPFIVSPPENITVNISQDAL 247
           GSL + + ++ +D G Y C A +  G  V     L       F       ++V   Q  +
Sbjct: 82  GSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMV 141

Query: 248 LTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSN 307
           L C    + G L+Y W + +   Y  N    R      G L I +V+  D G YTCV +N
Sbjct: 142 LLCGPPPHSGELSYAWIFNEYPSYQDN---RRFVSQETGNLYIAKVEKSDVGNYTCVVTN 198

Query: 308 SLGR----SPSASAYL-----TVQYPARV-LNMPPVIYVPVGIHGYIRCPVDAEPPATVV 357
           ++       P     L       +Y  ++ +  P  +    G    + C     P  T++
Sbjct: 199 TVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTII 258

Query: 358 KWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLK 417
               DG+P+  +         +G + I    +E  G Y CV  N+ G        + V +
Sbjct: 259 WRRADGKPIARKAR---RHKSNGILEIPNFQQEDAGLYECVAENSRG--------KNVAR 307

Query: 418 DPPYFTVLPGW-----EYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSK-HSALPSG 471
               F   P W     +        +   C A G P P   W K G+P  ++    +  G
Sbjct: 308 GQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQG 367

Query: 472 SLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSP 510
           +L    ++  D G ++C+A N    I ++  L+VI   P
Sbjct: 368 TLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGP 406



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 156/699 (22%), Positives = 260/699 (37%), Gaps = 95/699 (13%)

Query: 39  ESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASL 98
           + V L C+V     G P P++  W   G  +   + F Y             S+ + + L
Sbjct: 44  KKVKLNCEV----KGNPKPHI-RWKLNGTDVDTGMDFRY-------------SVVEGSLL 85

Query: 99  RLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSIT 158
                +++D G Y+C        + T  +     L       F       +  + G  + 
Sbjct: 86  INNPNKTQDAGTYQCTAT---NSFGTIVSRE-AKLQFAYLDNFKTRTRSTVSVRRGQGMV 141

Query: 159 MTCTAFGNPKPIVTWLKEGTLLGASGKYQVS-------DGSLTVTSVSREDRGAYTCRAY 211
           + C     P P    L    +      YQ +        G+L +  V + D G YTC   
Sbjct: 142 LLC----GPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVT 197

Query: 212 SIQGEAVHTTHLLVQGPP-----------------FIVSPPENITVNISQDALLTCRAEA 254
           +        T+  V GPP                   V  PE +         L C A  
Sbjct: 198 NT------VTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALG 251

Query: 255 YPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPS 314
            P   T  W   D     +   K R R   +G L I   + ED+G Y CV  NS G++  
Sbjct: 252 NPVP-TIIWRRADGKPIAR---KAR-RHKSNGILEIPNFQQEDAGLYECVAENSRGKNV- 305

Query: 315 ASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGW 374
           A   LT       +     I+V +  + +  C  +  P  T  KW K+G PL     +  
Sbjct: 306 ARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTY-KWLKNGEPLLTRDRIQ- 363

Query: 375 TLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEA 434
             +E G++ I        G Y C+  N  G +  +A   ++   P +   L       + 
Sbjct: 364 --IEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKV 421

Query: 435 GRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALP---SGSLQFRALSKEDHGEWECVAT 491
           G E++I C     P PV TW+K G+    ++  +     G+L+   ++K D G + C+AT
Sbjct: 422 GGEVVIECKPKASPKPVYTWKK-GRDILKENERITISEDGNLRIINVTKSDAGSYTCIAT 480

Query: 492 NVVTSITASTHLTVIGTSPHA--PGSVRVQVS---MTTANVSWEPGYDGGYEQTFSVWMK 546
           N   + +++ +L V   +     P S+ V V    +    V+ +   D  +  +F+  + 
Sbjct: 481 NHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLI 540

Query: 547 RAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGT-SAFSEVVTVNTLAFP 605
                   +  +        L++  ++ + A ++  + Q  +   SA ++++        
Sbjct: 541 DFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGP---- 596

Query: 606 ITTPEPLVLVTPPRCLIANRTQQGVLLSWLP-PANHSFPIDRYIMEFRV--AERWELLDD 662
              P P   VT     I   T     LSW P P NHS PI  Y+++ R   +  W+ +  
Sbjct: 597 ---PGPPEAVT-----IDEITDTTAQLSWRPGPDNHS-PITMYVIQARTPFSVGWQAVST 647

Query: 663 GIPGTEGE-FFAKDLSQDTW--YEFRVLAVMQDLISEPS 698
                +G+ F A  +  + W  YEFR +A     I EPS
Sbjct: 648 VPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPS 686



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 83/339 (24%), Positives = 128/339 (37%), Gaps = 21/339 (6%)

Query: 225 VQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILI 284
           + GP FI  P   +    S++  +    E   GN      W+         +  R  ++ 
Sbjct: 23  LHGPIFIQEPSPVMFPLDSEEKKVKLNCEV-KGNPKPHIRWKLNGTDVDTGMDFRYSVVE 81

Query: 285 DGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARV-LNMPPVIYVPVGIHGY 343
              LI    K +D+G Y C  +NS G   S  A L   Y           + V  G    
Sbjct: 82  GSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMV 141

Query: 344 IRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTL 403
           + C            W  +  P   + N  +   E G++ I +  +  +G YTCV  NT+
Sbjct: 142 LLCGPPPHSGELSYAWIFNEYP-SYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTV 200

Query: 404 -GTMGQSAPARLVLKDPPYFTVLPGWEYRQEA----------GRELLIPCAAAGDPFPVI 452
                   P  L+L++     V+  +E + E           G  + + C A G+P P I
Sbjct: 201 TNHKVLGPPTPLILRND---GVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTI 257

Query: 453 TWRKV-GKP-SRSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSP 510
            WR+  GKP +R       +G L+     +ED G +ECVA N      A   LT      
Sbjct: 258 IWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPN 317

Query: 511 HAPGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMKRAQ 549
                  + V+M   NV WE   +G  + T+  W+K  +
Sbjct: 318 WIQKINDIHVAM-EENVFWECKANGRPKPTYK-WLKNGE 354


>gi|81158226 neuronal cell adhesion molecule isoform A precursor
           [Homo sapiens]
          Length = 1304

 Score =  143 bits (361), Expect = 1e-33
 Identities = 152/606 (25%), Positives = 245/606 (40%), Gaps = 57/606 (9%)

Query: 27  REEPEFVTARAGESVVLRCDVIHPVTGQPPPYVV------------EWFKFGVPIPIFIK 74
           +E+ E +T ++G+S+VL C    P  G PPP +             E    G+   ++  
Sbjct: 149 KEKLEPITLQSGQSLVLPC---RPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFS 205

Query: 75  FGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGS----- 129
               P     +Y   A  +   +++ +Q  S        KV+ +D+  DT          
Sbjct: 206 -NVLPEDTREDYICYARFNHTQTIQQKQPIS-------VKVISVDELNDTIAANLSDTEF 257

Query: 130 -WVHLTINAPPTFTETPPQYIEAKE---GGSITMTCTAFGNPKPIVTWLKEGTLLGASGK 185
                +   PPTF  TP      KE   G  +++ C A G P PI+ W KE  +L  +  
Sbjct: 258 YGAKSSRERPPTFL-TPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRT 316

Query: 186 -YQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQ 244
            Y+  + +L +  VS  D G Y C A +  G   HT  + V+  P+ ++ P+N+ ++  +
Sbjct: 317 VYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGE 376

Query: 245 DALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIF-RVKPEDSGKYTC 303
           D  L CRA   P     +W      +    D   R    IDG  IIF  V+   S  Y C
Sbjct: 377 DGTLICRANGNP-KPRISWLTNGVPIEIAPDDPSR---KIDGDTIIFSNVQERSSAVYQC 432

Query: 304 VPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDG 363
             SN  G   + +    +  P R+L     +Y  +     +        P   ++W K  
Sbjct: 433 NASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGA 492

Query: 364 RPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFT 423
           +   + +++ + L E+G++ I  A +++ GTYTCV  N LG         L +KDP +  
Sbjct: 493 KGSALHEDI-YVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNE--VHLEIKDPTWIV 549

Query: 424 VLPGWEYRQEAGRELLIPCAAAGDPFPVIT--WRKVGKPSRS-KHSALPSGSLQFRALSK 480
             P +   Q  G  +   C    D    +T  W K  +   S +   +    L    +S 
Sbjct: 550 KQPEYAVVQR-GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSD 608

Query: 481 EDHGEWECVATNVVTSITASTHLTVIGTS---------PHAPGSVRVQVSM-TTANVSWE 530
           +D G + CVA   + S++AS  L+V+  +         P+ P  + +   +  +  +SW 
Sbjct: 609 DDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWT 668

Query: 531 PGYDGGYEQT-FSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLG 589
           PG D     T F +  + A   P  W       G        L P   Y F V+A N +G
Sbjct: 669 PGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIG 728

Query: 590 TSAFSE 595
            S  SE
Sbjct: 729 KSLPSE 734



 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 167/718 (23%), Positives = 257/718 (35%), Gaps = 121/718 (16%)

Query: 30   PEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGR 89
            P+ +    GE   L C       G P P +  W   GVPI I            P+   R
Sbjct: 367  PQNLVLSPGEDGTLICRA----NGNPKPRI-SWLTNGVPIEIA-----------PDDPSR 410

Query: 90   ASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYI 149
                D  ++    V+      Y+C       +Y      ++V++    P   T     Y 
Sbjct: 411  KI--DGDTIIFSNVQERSSAVYQCNA---SNEYGYLLANAFVNVLAEPPRILTPANTLY- 464

Query: 150  EAKEGGSITMTCTAFGNPKPIVTWLK--EGTLLGASGKYQVSDGSLTVTSVSREDRGAYT 207
            +        + C  FG+P P + W K  +G+ L         +G+L +    ++  G YT
Sbjct: 465  QVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYT 524

Query: 208  CRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQD 267
            C A +  G A +  HL ++ P +IV  PE   V         C+ + +   L+ T  W  
Sbjct: 525  CVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVK-HDHTLSLTVLWLK 583

Query: 268  ENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARV 327
            +N    +D +  V       L++  V  +DSG YTCV + +L  S SASA L+V  P   
Sbjct: 584  DNRELPSDERFTVD---KDHLVVADVSDDDSGTYTCVANTTLD-SVSASAVLSVVAPTPT 639

Query: 328  LNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGS------ 381
                PV  VP              PP  +   ++  + +Q    L WT  +D +      
Sbjct: 640  --PAPVYDVP-------------NPPFDLELTDQLDKSVQ----LSWTPGDDNNSPITKF 680

Query: 382  -IRIEEATE---------EALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYR 431
             I  E+A           E  GT T         +  S     V             +Y 
Sbjct: 681  IIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYL 740

Query: 432  QEAGRELLIPCAAAG---DPFP-VITWRKVGKPSRSKHSALPSGSLQFRALSKEDHGEW- 486
             +A      P A  G   +P   VITW    KP     S  P    +     K+   EW 
Sbjct: 741  TKASEPDKNPTAVEGLGSEPDNLVITW----KPLNGFESNGPGLQYKVSWRQKDGDDEWT 796

Query: 487  ECVATNVVTSITASTHLTV-----------IGTSPH---------------APGSVRVQV 520
              V  NV   I + T   V           +G +P                APG+VRV V
Sbjct: 797  SVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNV 856

Query: 521  -SMTTANVSWEP---GYDGGYEQTFSVWMKRAQFGPH------DWLSLPVPPGPSWLLVD 570
             + T A V W+P       G+ Q + ++  + Q          +   L      +  ++ 
Sbjct: 857  VNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLP 916

Query: 571  TLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEPLVLVTPPRCLIANRTQQGV 630
             LEP + Y  +V   N  G    S     NT     + P  L +V P        T   +
Sbjct: 917  GLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNP--------TLDSL 968

Query: 631  LLSWLPPANHSFPIDRYIMEFR----VAERWELLDDGIPGTEGEFFAKDLSQDTWYEF 684
             L W PP++ +  +  Y ++++      E   L+D  IP  +  +  K+L+  T Y+F
Sbjct: 969  TLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKF 1026



 Score = 70.9 bits (172), Expect = 8e-12
 Identities = 118/566 (20%), Positives = 210/566 (37%), Gaps = 69/566 (12%)

Query: 138 PPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVS----DGSL 193
           PPT T+  P+        +I + C A G P P  +W + GT         V+     G+L
Sbjct: 45  PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTL 104

Query: 194 TVTSVSRED----RGAYTCRAYSIQGEAVHTTHLL--VQGPPFIVSPPENITVNISQDAL 247
            +  +S        G Y C A + +G AV    ++   + P +     E IT+   Q  +
Sbjct: 105 IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLV 164

Query: 248 LTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGK-YTC--- 303
           L CR     G      +W D N + +     RV   ++G L    V PED+ + Y C   
Sbjct: 165 LPCRPPI--GLPPPIIFWMD-NSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYAR 221

Query: 304 -----------------VPSNSLGRSPSASAYLTVQYPAR-VLNMPPVIYVPVG------ 339
                            +  + L  + +A+   T  Y A+     PP    P G      
Sbjct: 222 FNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKE 281

Query: 340 -IHGYI---RCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTY 395
            + G +    C  +  P   +    +DG    + KN       + +++I   +E   G Y
Sbjct: 282 ELRGNVLSLECIAEGLPTPIIYWAKEDG---MLPKNRTVYKNFEKTLQIIHVSEADSGNY 338

Query: 396 TCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWR 455
            C+  N LG +  +   R  +K  PY+   P        G +  + C A G+P P I+W 
Sbjct: 339 QCIAKNALGAIHHTISVR--VKAAPYWITAP-QNLVLSPGEDGTLICRANGNPKPRISWL 395

Query: 456 KVGKPSR----SKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPH 511
             G P           +   ++ F  + +     ++C A+N    + A+  + V+   P 
Sbjct: 396 TNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPR 455

Query: 512 --APGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLV 569
              P +   QV +       +  + G    T   W K A+ G      + V      L +
Sbjct: 456 ILTPANTLYQV-IANRPALLDCAFFGSPLPTIE-WFKGAK-GSALHEDIYVLHENGTLEI 512

Query: 570 DTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEPLVL----VTPPRCLIANR 625
              + ++   ++ +A+NKLG +     + +    + +  PE  V+    +    C + + 
Sbjct: 513 PVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHD 572

Query: 626 TQQGVLLSWLP-----PANHSFPIDR 646
               + + WL      P++  F +D+
Sbjct: 573 HTLSLTVLWLKDNRELPSDERFTVDK 598


>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
          Length = 1447

 Score =  143 bits (360), Expect = 1e-33
 Identities = 152/571 (26%), Positives = 233/571 (40%), Gaps = 60/571 (10%)

Query: 154 GGSITMTCTAFGNPK-PIVTWLKEGTLLGAS---GKYQVSDGSLTVTSV-----SREDRG 204
           GG++ + C+A  +   P++ W K+G  L       K Q+S+GSL + ++      + D G
Sbjct: 54  GGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEG 113

Query: 205 AYTCRAYSIQGEAV--HTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYT 262
            Y C A      ++   T  + V GP   +S  E++T  +    LL C     P     T
Sbjct: 114 LYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEP---MPT 170

Query: 263 WYWQDENVYFQNDLK-----LRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASA 317
            +WQ      Q DL       RV +L  G L I R++P D G Y C   N         A
Sbjct: 171 IHWQKN----QQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEA 226

Query: 318 YLTVQYPARV------LNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKN 371
            + +     +      L  P  +    G    + C V   PP +   W +    +Q+ ++
Sbjct: 227 EVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFT-WLRGEEVIQL-RS 284

Query: 372 LGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYR 431
             ++L+   ++ I   T++  G YTCV   T      SA A L +  PP+F   P   Y 
Sbjct: 285 KKYSLLGGSNLLISNVTDDDSGMYTCVV--TYKNENISASAELTVLVPPWFLNHPSNLYA 342

Query: 432 QEAGRELLIPCAAAGDPFPVITWRKVGKPS-RSKHSALPSGS-LQFRALSKEDHGEWECV 489
            E+  ++   C  +G P P + W K G     S +  +  GS L+   + K D G ++CV
Sbjct: 343 YES-MDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCV 401

Query: 490 ATNVVTSITASTHLTV-------IGTSPHAPGSV-RVQVSMTTANVSWEPGYDG-GYEQT 540
           A N   +   S  L V           P AP  V  V VS     +SW P  +  G  QT
Sbjct: 402 AENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQT 461

Query: 541 FSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVN 600
           F+V+  R        L+    PG   L V  L+PE  Y F V+A N+ G    S+ + V 
Sbjct: 462 FTVFFSREGDNRERALNT-TQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKV- 519

Query: 601 TLAFPITTPEPLVLVTPPRCLIANRTQQGVLLSWLPPANHSFPIDRYIM---EFRVAERW 657
                 T PE  V          + +   +L++W PPA  + P+  Y +   E    +  
Sbjct: 520 -----ATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQ 574

Query: 658 ELLDDGIPGTEGEFFAKDLSQDTWYEFRVLA 688
            +  DG+      +  + L + T Y  R LA
Sbjct: 575 NIEVDGL-----SYKLEGLKKFTEYSLRFLA 600



 Score =  103 bits (257), Expect = 1e-21
 Identities = 171/686 (24%), Positives = 262/686 (38%), Gaps = 99/686 (14%)

Query: 15  TRGLAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFG---VPIPI 71
           T  +A  G      + E VTA  G++V+L+C+VI    G+P P  + W K      PIP 
Sbjct: 131 TAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVI----GEPMP-TIHWQKNQQDLTPIP- 184

Query: 72  FIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWV 131
                            R  +    +L++ +++  D G Y C      +   +   G+  
Sbjct: 185 --------------GDSRVVVLPSGALQISRLQPGDIGIYRCSA----RNPASSRTGNEA 226

Query: 132 HLTINAPP-----TFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLK-EGTLLGASGK 185
            + I + P      +    P  + A EG    + C   G P P  TWL+ E  +   S K
Sbjct: 227 EVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKK 286

Query: 186 YQVSDGS-LTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQ 244
           Y +  GS L +++V+ +D G YTC           +  L V  PP+ ++ P N+    S 
Sbjct: 287 YSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESM 346

Query: 245 DALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCV 304
           D    C     P   T  W  ++ +V   +D     +I+    L I  V   D G Y CV
Sbjct: 347 DIEFECTVSGKPVP-TVNW-MKNGDVVIPSDY---FQIVGGSNLRILGVVKSDEGFYQCV 401

Query: 305 PSNSLGRSPSASAYLTVQYPA----RVLNMPPVIYVPVGIHG-YIRCPVDAEPPAT---- 355
             N  G +   SA L V  PA     VL   P   VPV +   ++R  +   PPA     
Sbjct: 402 AENEAGNA-QTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVR--LSWRPPAEAKGN 458

Query: 356 ----VVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAP 411
                V ++++G     E+ L  T      + +     EA+ T+  V YN  G    S P
Sbjct: 459 IQTFTVFFSREGD--NRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQP 516

Query: 412 ARLVLKDPPYFTVLPGWEYRQEAG---RELLI---PCAAAGDPFP----VITWRKVGKPS 461
            ++  +  P   V    E  Q        +LI   P A A  P        T    GK  
Sbjct: 517 IKVATQ--PELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQ 574

Query: 462 RSKHSAL----------PSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPH 511
             +   L             SL+F A ++   G    V+T+ +T +T    L+ + ++P 
Sbjct: 575 NIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPG----VSTDDITVVT----LSDVPSAPP 626

Query: 512 APGSVRVQVSMTTANVSWEP---GYDGGYEQTFSV-WMKRAQFGPHDWLSLPVPPGPSWL 567
              S+ V V+  +  VSW P   G   G+   + +   K  + G  + L     P   W 
Sbjct: 627 QNVSLEV-VNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLE----PNNLWY 681

Query: 568 LVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEPLVLVTPPRCLIANRTQ 627
           L   LE  + Y F V A    GT   S   T  T   P    +   +   P  L      
Sbjct: 682 LFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAET---PENDLDESQVPDQPSSLHVRPQT 738

Query: 628 QGVLLSWLPPANHSFPIDRYIMEFRV 653
             +++SW PP N +  +  YI+ + V
Sbjct: 739 NCIIMSWTPPLNPNIVVRGYIIGYGV 764



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 50/187 (26%), Positives = 78/187 (41%), Gaps = 15/187 (8%)

Query: 326 RVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIE 385
           R L+ P       G +  + C  +++    V+KW KDG  L +  +     + +GS+ I+
Sbjct: 41  RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQ 100

Query: 386 EATEEA-----LGTYTCVPYNTLGTMGQ--SAPARLVLKDPPYFTVLPGWEYRQEAGREL 438
                       G Y C    +LG  G   S  A++ +  P  F +          G  +
Sbjct: 101 NILHSRHHKPDEGLYQCEA--SLGDSGSIISRTAKVAVAGPLRF-LSQTESVTAFMGDTV 157

Query: 439 LIPCAAAGDPFPVITWRKVGK-----PSRSKHSALPSGSLQFRALSKEDHGEWECVATNV 493
           L+ C   G+P P I W+K  +     P  S+   LPSG+LQ   L   D G + C A N 
Sbjct: 158 LLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNP 217

Query: 494 VTSITAS 500
            +S T +
Sbjct: 218 ASSRTGN 224



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 34/121 (28%), Positives = 55/121 (45%), Gaps = 10/121 (8%)

Query: 572  LEPETAYQFSVLAQNKLGTSAFSEVVTVNTL-AFPITTPEPLVLVTPPRCLIANRTQQGV 630
            L+P T Y+FSV+      +S +S      T  A P + P+ L ++T           + V
Sbjct: 910  LKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVIT------REGKPRAV 963

Query: 631  LLSWLPPANHSFPIDRYIMEFRVAERWELLD---DGIPGTEGEFFAKDLSQDTWYEFRVL 687
            ++SW PP   +  I  YI+ + + +   + D   + I G        DL+ DT Y FR+ 
Sbjct: 964  IVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQ 1023

Query: 688  A 688
            A
Sbjct: 1024 A 1024


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score =  140 bits (354), Expect = 6e-33
 Identities = 106/370 (28%), Positives = 161/370 (43%), Gaps = 20/370 (5%)

Query: 146 PQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVS---DGSLTVTSVSRED 202
           PQ  +   G ++  TC A GNPKP + WL+    L      +++   DG+L + +    D
Sbjct: 252 PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETD 311

Query: 203 RGAYTCRAYSIQGEAVHTTHLLVQ-----GPPFIVSPPENITVNISQDALLTCRAEAYPG 257
           +G Y C A ++ GE V T  + ++       P  V  P+N  V + +   L C A  +P 
Sbjct: 312 QGIYQCMAKNVAGE-VKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPP 370

Query: 258 NLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASA 317
               +W   D        +  RV I   G L I  V   DSG+Y C  +N++  S  A+A
Sbjct: 371 P-RISWTRGDRTPL---PVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNID-SVHATA 425

Query: 318 YLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLM 377
           ++ VQ   +    P    V  G     +C     PP  V+ W K G  L V++     ++
Sbjct: 426 FIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPP-PVIAWTKGGSQLSVDRR--HLVL 482

Query: 378 EDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRE 437
             G++RI        G Y C   N +G+    A   +  +  P F  +P  +   E G  
Sbjct: 483 SSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPS-DTTVEVGAN 541

Query: 438 LLIPCAAAGDPFPVITWRKVG--KPSRSKHSALPSGSLQFRALSKEDHGEWECVATNVVT 495
           + +PC++ G+P P ITW K G       K    P G L    +   D G +ECVA N + 
Sbjct: 542 VQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIG 601

Query: 496 SITASTHLTV 505
           S + S  L+V
Sbjct: 602 SASVSMVLSV 611



 Score =  114 bits (285), Expect = 6e-25
 Identities = 107/383 (27%), Positives = 161/383 (42%), Gaps = 27/383 (7%)

Query: 229 PFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTL 288
           P I S P++  V        TCRAE   GN      W   N         R+ +L DGTL
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAE---GNPKPEIIWLRNNNELSMKTDSRLNLLDDGTL 302

Query: 289 IIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQY---PAR--VLNMPPVIYVPVGIHGY 343
           +I   +  D G Y C+  N  G   +    +T++Y   PAR   +  P    V VG    
Sbjct: 303 MIQNTQETDQGIYQCMAKNVAGEVKTQE--VTLRYFGSPARPTFVIQPQNTEVLVGESVT 360

Query: 344 IRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTL 403
           + C     PP  +     D  PL V+  +  T    G + I+   +   G Y C   N +
Sbjct: 361 LECSATGHPPPRISWTRGDRTPLPVDPRVNIT--PSGGLYIQNVVQGDSGEYACSATNNI 418

Query: 404 GTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSR- 462
            ++   A A ++++  P FTV P      E G+ +   C A G+P PVI W K G     
Sbjct: 419 DSV--HATAFIIVQALPQFTVTPQDRVVIE-GQTVDFQCEAKGNPPPVIAWTKGGSQLSV 475

Query: 463 -SKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLT----VIGTSPHAPGSVR 517
             +H  L SG+L+   ++  D G++EC A N++ S     HLT    V       P    
Sbjct: 476 DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535

Query: 518 VQVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETA 577
           V+V    ANV   P    G  +    W K              P G  +L ++ + P  A
Sbjct: 536 VEVG---ANVQL-PCSSQGEPEPAITWNKDGVQVTESGKFHISPEG--FLTINDVGPADA 589

Query: 578 YQFSVLAQNKLGTSAFSEVVTVN 600
            ++  +A+N +G+++ S V++VN
Sbjct: 590 GRYECVARNTIGSASVSMVLSVN 612



 Score =  107 bits (267), Expect = 8e-23
 Identities = 102/389 (26%), Positives = 165/389 (42%), Gaps = 35/389 (8%)

Query: 26  LREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPE 85
           +  EP+     +G +V   C       G P P ++ W +    + +             +
Sbjct: 248 ITSEPQDADVTSGNTVYFTCRA----EGNPKPEII-WLRNNNELSM-------------K 289

Query: 86  YAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETP 145
              R +L D  +L ++  +  DQG Y+C    +  +  T    +  +    A PTF    
Sbjct: 290 TDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKT-QEVTLRYFGSPARPTFV-IQ 347

Query: 146 PQYIEAKEGGSITMTCTAFGNPKPIVTWLK-EGTLLGASGKYQVS-DGSLTVTSVSREDR 203
           PQ  E   G S+T+ C+A G+P P ++W + + T L    +  ++  G L + +V + D 
Sbjct: 348 PQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDS 407

Query: 204 GAYTCRAYSIQGEAVHTTHLLVQG-PPFIVSPPENITVNISQDALLTCRAEAYPGNLTYT 262
           G Y C A +       T  ++VQ  P F V+P + + +   Q     C A+   GN    
Sbjct: 408 GEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIE-GQTVDFQCEAK---GNPPPV 463

Query: 263 WYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQ 322
             W       Q  +  R  +L  GTL I  V   D G+Y C   N +G S    A+LTVQ
Sbjct: 464 IAWTKGG--SQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIG-SQKVVAHLTVQ 520

Query: 323 YPARVL--NMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDG 380
                +  ++P    V VG +  + C    EP   +  WNKDG  +QV ++  + +  +G
Sbjct: 521 PRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAIT-WNKDG--VQVTESGKFHISPEG 577

Query: 381 SIRIEEATEEALGTYTCVPYNTLGTMGQS 409
            + I +      G Y CV  NT+G+   S
Sbjct: 578 FLTINDVGPADAGRYECVARNTIGSASVS 606



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 60/235 (25%), Positives = 96/235 (40%), Gaps = 36/235 (15%)

Query: 9   IASVIGTRGLAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVP 68
           I SV  T  +  +        P+      G++V  +C+      G PPP V+ W K G  
Sbjct: 418 IDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEA----KGNPPP-VIAWTKGGSQ 472

Query: 69  IPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNG 128
           + +                 R  +    +LR+  V   DQG YEC+ + +          
Sbjct: 473 LSV---------------DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVV--- 514

Query: 129 SWVHLTIN--APPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKY 186
              HLT+     P F   P      + G ++ + C++ G P+P +TW K+G  +  SGK+
Sbjct: 515 --AHLTVQPRVTPVFASIPSD-TTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKF 571

Query: 187 QVS-DGSLTVTSVSREDRGAYTCRAYSIQGEA-------VHTTHLLVQGPPFIVS 233
            +S +G LT+  V   D G Y C A +  G A       V+   +   G PF+ +
Sbjct: 572 HISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVAT 626


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score =  138 bits (348), Expect = 3e-32
 Identities = 113/390 (28%), Positives = 167/390 (42%), Gaps = 22/390 (5%)

Query: 146 PQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVS---DGSLTVTSVSRED 202
           PQ +E   G ++  TC A GNPKP + W+     L      +++   DG+L + +    D
Sbjct: 240 PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESD 299

Query: 203 RGAYTCRAYSIQGEAVHTTHLL----VQGPPFIVSPPENITVNISQDALLTCRAEAYPGN 258
           +G Y C A +  GEA   + +L    +   P  V  P++  V I     L C A  +P  
Sbjct: 300 QGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHP 359

Query: 259 LTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAY 318
           L  TW  +D  +    +L     +     L +  +   D G++TC  +NS G +  A+A 
Sbjct: 360 LI-TWT-RDNGL----ELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHG-TVQAAAN 412

Query: 319 LTVQYPARVLNMPPVIYVPVGIHGYI-RCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLM 377
           + VQ P +   + P   V +  H     C  D  PP  +V W K G  L VE     T++
Sbjct: 413 IIVQAPPQ-FTVTPKDQVVLEEHAVEWLCEADGNPPPVIV-WTKTGGQLPVEGQ--HTVL 468

Query: 378 EDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRE 437
             G++RI+ A +   G Y C   ++LG    S    +  K    FT LP  +   E G+ 
Sbjct: 469 SSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQ-DTSVEVGKN 527

Query: 438 LLIPCAAAGDPFPVITWRKVGK--PSRSKHSALPSGSLQFRALSKEDHGEWECVATNVVT 495
           + I C A G+P P+ITW K G       K      G+L        D G +ECVA N   
Sbjct: 528 INISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587

Query: 496 SITASTHLTVIGTSPHAPGSVRVQVSMTTA 525
               +  LTV        G   V+ S+  A
Sbjct: 588 LAVTNMFLTVTAIQGRQAGDDFVESSILDA 617



 Score =  115 bits (288), Expect = 3e-25
 Identities = 100/379 (26%), Positives = 167/379 (44%), Gaps = 33/379 (8%)

Query: 29  EPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAG 88
           EP+ V   +G +V   C       G P P ++ W              +    +D E   
Sbjct: 239 EPQDVEVPSGNTVYFTCRA----EGNPKPEII-WI-------------HNNHSLDLEDDT 280

Query: 89  RASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQY 148
           R ++ D  +L +   R  DQG Y+C       +  T  +    + ++ A P+F    PQ 
Sbjct: 281 RLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKT-QSAMLRYSSLPAKPSFV-IQPQD 338

Query: 149 IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSREDRGAYTC 208
            E   G S T+ C A G+P P++TW ++  L     ++  +   L + ++++ D G +TC
Sbjct: 339 TEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTC 398

Query: 209 RAYSIQGEAVHTTHLLVQGPP-FIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQD 267
            A +  G      +++VQ PP F V+P + + +       L C A+   GN      W  
Sbjct: 399 HANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWL-CEAD---GNPPPVIVWTK 454

Query: 268 ENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARV 327
                Q  ++ +  +L  GTL I R    D G+Y C   +SLG     S  LTV+  A  
Sbjct: 455 TG--GQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLG-VKKVSVQLTVKPKALA 511

Query: 328 L--NMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIE 385
           +   +P    V VG +  I C    E P  ++ WNK+G  +Q+ ++  + + ++G++ I 
Sbjct: 512 VFTQLPQDTSVEVGKNINISCHAQGE-PQPIITWNKEG--VQITESGKFHVDDEGTLTIY 568

Query: 386 EATEEALGTYTCVPYNTLG 404
           +A     G Y CV  N+ G
Sbjct: 569 DAGFPDQGRYECVARNSFG 587



 Score =  105 bits (263), Expect = 2e-22
 Identities = 83/284 (29%), Positives = 131/284 (46%), Gaps = 19/284 (6%)

Query: 229 PFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTL 288
           P I   P+++ V        TCRAE  P      W   + ++  ++D +L V    DGTL
Sbjct: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNP-KPEIIWIHNNHSLDLEDDTRLNV--FDDGTL 290

Query: 289 IIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTV-QYPAR--VLNMPPVIYVPVGIHGYIR 345
           +I   +  D G Y C+  NS G + + SA L     PA+   +  P    V +G    + 
Sbjct: 291 MIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLE 350

Query: 346 CPVDAEPPATVVKWNKD-GRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLG 404
           C      P  ++ W +D G  L   +++         + ++  T+   G +TC   N+ G
Sbjct: 351 CMATGH-PHPLITWTRDNGLELDGSRHVA----TSSGLYLQNITQRDHGRFTCHANNSHG 405

Query: 405 TMGQSAPARLVLKDPPYFTVLPGWE-YRQEAGRELLIPCAAAGDPFPVITWRKVG--KPS 461
           T+   A A ++++ PP FTV P  +   +E   E L  C A G+P PVI W K G   P 
Sbjct: 406 TV--QAAANIIVQAPPQFTVTPKDQVVLEEHAVEWL--CEADGNPPPVIVWTKTGGQLPV 461

Query: 462 RSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTV 505
             +H+ L SG+L+    ++ D G++EC A + +     S  LTV
Sbjct: 462 EGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV 505


>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
          Length = 1174

 Score =  137 bits (346), Expect = 5e-32
 Identities = 123/453 (27%), Positives = 192/453 (42%), Gaps = 32/453 (7%)

Query: 154 GGSITMTCTAFGNPKPIVTWLKEG-TLLGASGKYQVSDGSLTVTSVSREDRGAYTCRAYS 212
           G  + + C A G P P + W K+G  L     K++  + +L +T+VS ED G Y C A +
Sbjct: 272 GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 331

Query: 213 IQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYF 272
             G   HT  + V+  P+ +  P+N+ +   +D  L CRA    GN   T  W       
Sbjct: 332 KMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN---GNPKPTVQWMVNGEPL 388

Query: 273 QNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPP 332
           Q+      R +   T+I    +      Y C  SN  G       YL       VL++PP
Sbjct: 389 QSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHG-------YLLANAFVSVLDVPP 441

Query: 333 VIYVP----VGIHGYIRCPVDAE---PPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIE 385
            +  P    + +  Y R  +D      P   ++W K+G+   ++    + + E+GS+ I+
Sbjct: 442 RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGG-NYHVYENGSLEIK 500

Query: 386 EATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAA 445
              +E  G YTCV  N LG        RL +KDP     +P  +  +  G  + + C   
Sbjct: 501 MIRKEDQGIYTCVATNILGKAENQ--VRLEVKDPTRIYRMPEDQVARR-GTTVQLECRVK 557

Query: 446 GDPFPVIT--WRKVGKP----SRSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITA 499
            DP   +T  W K  +P    +R K       SL    +++ D G + CVA+  +    A
Sbjct: 558 HDPSLKLTVSWLKDDEPLYIGNRMKKE---DDSLTIFGVAERDQGSYTCVASTELDQDLA 614

Query: 500 STHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQT-FSVWMKRAQFGPHDWLSL 558
             +LTV+G            ++  +  ++W PG       T + V  +  QF P  W   
Sbjct: 615 KAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDH 674

Query: 559 PVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTS 591
              PG     V  L P   YQF V+A N++G+S
Sbjct: 675 SKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSS 707



 Score = 88.6 bits (218), Expect = 4e-17
 Identities = 92/347 (26%), Positives = 141/347 (40%), Gaps = 25/347 (7%)

Query: 59  VVEWFKFGVPIPIFIKFGYYPPHVD-PEYAGRASLHDKASLRLEQVRSEDQGWYECKVLM 117
           ++E    GVP P      +Y    D P    +    +KA LR+  V  ED G Y C  L 
Sbjct: 276 LLECIASGVPTP---DIAWYKKGGDLPSDKAKFENFNKA-LRITNVSEEDSGEYFC--LA 329

Query: 118 LDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEG 177
            ++     H    + + + A P + + P   I A  G    + C A GNPKP V W+  G
Sbjct: 330 SNKMGSIRHT---ISVRVKAAPYWLDEPKNLILAP-GEDGRLVCRANGNPKPTVQWMVNG 385

Query: 178 TLLGA---SGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHL-LVQGPPFIVS 233
             L +   +   +V+  ++         R  Y C   +  G  +    + ++  PP ++S
Sbjct: 386 EPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS 445

Query: 234 PPEN-ITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFR 292
           P    I V +     L C     P   T  W+   +             +  +G+L I  
Sbjct: 446 PRNQLIRVILYNRTRLDCPFFGSP-IPTLRWFKNGQGSNLDGG---NYHVYENGSLEIKM 501

Query: 293 VKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEP 352
           ++ ED G YTCV +N LG++ +    L V+ P R+  MP       G    + C V  +P
Sbjct: 502 IRKEDQGIYTCVATNILGKAEN-QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDP 560

Query: 353 PATV-VKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCV 398
              + V W KD  PL +   +     ED S+ I    E   G+YTCV
Sbjct: 561 SLKLTVSWLKDDEPLYIGNRM---KKEDDSLTIFGVAERDQGSYTCV 604



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 97/432 (22%), Positives = 161/432 (37%), Gaps = 69/432 (15%)

Query: 131 VHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVS- 189
           + + +  PPT T+   +        +I + C A GNP P   W +       +   +VS 
Sbjct: 27  IPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 86

Query: 190 ---DGSLTVTSVS----REDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENI-TVN 241
               G+L +   S     E  G Y C A +  G A+ +  + +Q     + P EN+  V 
Sbjct: 87  RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTAL-SNRIRLQVSKSPLWPKENLDPVV 145

Query: 242 ISQDALLTCRAEAYPGNLTYTWYW---------QDENV--------YFQN--------DL 276
           + + A LT +    PG  +   +W         QD+ V        YF N        D 
Sbjct: 146 VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 205

Query: 277 KLRVRILIDGTLIIFRVKPEDSGKYTCVPSN--SLGRSPS-------ASAYLTVQYPARV 327
               R     T  I +  P      T  P N  SL   P        A    +  YP   
Sbjct: 206 SCNARFHFTHT--IQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGT 263

Query: 328 LNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEA 387
            +   V+    G+   + C + +  P   + W K G  L  +K        + ++RI   
Sbjct: 264 ASSQMVLR---GMDLLLEC-IASGVPTPDIAWYKKGGDLPSDKAKFENF--NKALRITNV 317

Query: 388 TEEALGTYTCVPYNTLGTMGQSAPARLV-----LKDPPYFTVLPGWEYRQEAGRELLIPC 442
           +EE  G Y C+  N +G++  +   R+      L +P    + PG     E GR   + C
Sbjct: 318 SEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPG-----EDGR---LVC 369

Query: 443 AAAGDPFPVITWRKVGKPSRS----KHSALPSGSLQFRALSKEDHGEWECVATNVVTSIT 498
            A G+P P + W   G+P +S     +  +   ++ FR         ++C  +N    + 
Sbjct: 370 RANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLL 429

Query: 499 ASTHLTVIGTSP 510
           A+  ++V+   P
Sbjct: 430 ANAFVSVLDVPP 441


>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
          Length = 1169

 Score =  137 bits (346), Expect = 5e-32
 Identities = 123/453 (27%), Positives = 192/453 (42%), Gaps = 32/453 (7%)

Query: 154 GGSITMTCTAFGNPKPIVTWLKEG-TLLGASGKYQVSDGSLTVTSVSREDRGAYTCRAYS 212
           G  + + C A G P P + W K+G  L     K++  + +L +T+VS ED G Y C A +
Sbjct: 272 GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 331

Query: 213 IQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYF 272
             G   HT  + V+  P+ +  P+N+ +   +D  L CRA    GN   T  W       
Sbjct: 332 KMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN---GNPKPTVQWMVNGEPL 388

Query: 273 QNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPP 332
           Q+      R +   T+I    +      Y C  SN  G       YL       VL++PP
Sbjct: 389 QSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHG-------YLLANAFVSVLDVPP 441

Query: 333 VIYVP----VGIHGYIRCPVDAE---PPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIE 385
            +  P    + +  Y R  +D      P   ++W K+G+   ++    + + E+GS+ I+
Sbjct: 442 RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGG-NYHVYENGSLEIK 500

Query: 386 EATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAA 445
              +E  G YTCV  N LG        RL +KDP     +P  +  +  G  + + C   
Sbjct: 501 MIRKEDQGIYTCVATNILGKAENQ--VRLEVKDPTRIYRMPEDQVARR-GTTVQLECRVK 557

Query: 446 GDPFPVIT--WRKVGKP----SRSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITA 499
            DP   +T  W K  +P    +R K       SL    +++ D G + CVA+  +    A
Sbjct: 558 HDPSLKLTVSWLKDDEPLYIGNRMKKE---DDSLTIFGVAERDQGSYTCVASTELDQDLA 614

Query: 500 STHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQT-FSVWMKRAQFGPHDWLSL 558
             +LTV+G            ++  +  ++W PG       T + V  +  QF P  W   
Sbjct: 615 KAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDH 674

Query: 559 PVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTS 591
              PG     V  L P   YQF V+A N++G+S
Sbjct: 675 SKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSS 707



 Score = 88.6 bits (218), Expect = 4e-17
 Identities = 92/347 (26%), Positives = 141/347 (40%), Gaps = 25/347 (7%)

Query: 59  VVEWFKFGVPIPIFIKFGYYPPHVD-PEYAGRASLHDKASLRLEQVRSEDQGWYECKVLM 117
           ++E    GVP P      +Y    D P    +    +KA LR+  V  ED G Y C  L 
Sbjct: 276 LLECIASGVPTP---DIAWYKKGGDLPSDKAKFENFNKA-LRITNVSEEDSGEYFC--LA 329

Query: 118 LDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEG 177
            ++     H    + + + A P + + P   I A  G    + C A GNPKP V W+  G
Sbjct: 330 SNKMGSIRHT---ISVRVKAAPYWLDEPKNLILAP-GEDGRLVCRANGNPKPTVQWMVNG 385

Query: 178 TLLGA---SGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHL-LVQGPPFIVS 233
             L +   +   +V+  ++         R  Y C   +  G  +    + ++  PP ++S
Sbjct: 386 EPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS 445

Query: 234 PPEN-ITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFR 292
           P    I V +     L C     P   T  W+   +             +  +G+L I  
Sbjct: 446 PRNQLIRVILYNRTRLDCPFFGSP-IPTLRWFKNGQGSNLDGG---NYHVYENGSLEIKM 501

Query: 293 VKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEP 352
           ++ ED G YTCV +N LG++ +    L V+ P R+  MP       G    + C V  +P
Sbjct: 502 IRKEDQGIYTCVATNILGKAEN-QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDP 560

Query: 353 PATV-VKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCV 398
              + V W KD  PL +   +     ED S+ I    E   G+YTCV
Sbjct: 561 SLKLTVSWLKDDEPLYIGNRM---KKEDDSLTIFGVAERDQGSYTCV 604



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 97/432 (22%), Positives = 161/432 (37%), Gaps = 69/432 (15%)

Query: 131 VHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVS- 189
           + + +  PPT T+   +        +I + C A GNP P   W +       +   +VS 
Sbjct: 27  IPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 86

Query: 190 ---DGSLTVTSVS----REDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENI-TVN 241
               G+L +   S     E  G Y C A +  G A+ +  + +Q     + P EN+  V 
Sbjct: 87  RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTAL-SNRIRLQVSKSPLWPKENLDPVV 145

Query: 242 ISQDALLTCRAEAYPGNLTYTWYW---------QDENV--------YFQN--------DL 276
           + + A LT +    PG  +   +W         QD+ V        YF N        D 
Sbjct: 146 VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 205

Query: 277 KLRVRILIDGTLIIFRVKPEDSGKYTCVPSN--SLGRSPS-------ASAYLTVQYPARV 327
               R     T  I +  P      T  P N  SL   P        A    +  YP   
Sbjct: 206 SCNARFHFTHT--IQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGT 263

Query: 328 LNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEA 387
            +   V+    G+   + C + +  P   + W K G  L  +K        + ++RI   
Sbjct: 264 ASSQMVLR---GMDLLLEC-IASGVPTPDIAWYKKGGDLPSDKAKFENF--NKALRITNV 317

Query: 388 TEEALGTYTCVPYNTLGTMGQSAPARLV-----LKDPPYFTVLPGWEYRQEAGRELLIPC 442
           +EE  G Y C+  N +G++  +   R+      L +P    + PG     E GR   + C
Sbjct: 318 SEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPG-----EDGR---LVC 369

Query: 443 AAAGDPFPVITWRKVGKPSRS----KHSALPSGSLQFRALSKEDHGEWECVATNVVTSIT 498
            A G+P P + W   G+P +S     +  +   ++ FR         ++C  +N    + 
Sbjct: 370 RANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLL 429

Query: 499 ASTHLTVIGTSP 510
           A+  ++V+   P
Sbjct: 430 ANAFVSVLDVPP 441


>gi|7657359 contactin 5 isoform long [Homo sapiens]
          Length = 1100

 Score =  137 bits (345), Expect = 7e-32
 Identities = 156/611 (25%), Positives = 241/611 (39%), Gaps = 72/611 (11%)

Query: 33  VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
           V+ R G+ VVL C         PPP+  E     V       F  +P  V  E + R   
Sbjct: 205 VSVREGQGVVLMCS--------PPPHSPEIIYSWV-------FNEFPSFV-AEDSRRFIS 248

Query: 93  HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVH----LTINAPPTFTETPPQY 148
            +  +L + +V++ D G Y C V       +T  N   +     LT+       E  P+ 
Sbjct: 249 QETGNLYISKVQTSDVGSYICLVK------NTVTNARVLSPPTPLTLRNDGVMGEYEPKI 302

Query: 149 -------IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSRE 201
                  + A +G ++ M C A GNP P +TW+K    + +  + + S   L + +V  +
Sbjct: 303 EVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLD 362

Query: 202 DRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTY 261
           D G Y CRA + +G+      L V   P  V    +  ++        C+A   P   TY
Sbjct: 363 DAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKP-RPTY 421

Query: 262 TWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGR-SPSASAYLT 320
            W      +  Q+ ++     +++G L+I  V   D+G Y C+  N  G    SA   + 
Sbjct: 422 RWLKNGVPLSPQSRVE-----MVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKIL 476

Query: 321 VQYPARVLN-MPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMED 379
              P   LN +   I V       I C     P  T + W K  R ++  K +   ++ D
Sbjct: 477 ASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPT-ISWKKGDRAVRENKRI--AILPD 533

Query: 380 GSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELL 439
           GS+RI  A++   G Y C   N  G+      A L +K+P    + P        G  ++
Sbjct: 534 GSLRILNASKSDEGKYVCRGENVFGS--AEIIASLSVKEPTRIELTPK-RTELTVGESIV 590

Query: 440 IPCAAAGDPFPVIT--WRKVGKP---------SRSKHSALPSGSLQFRALSKEDHGEWEC 488
           + C A  D    +T  W   G+P           S  +   S  L  R +     G + C
Sbjct: 591 LNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGC 650

Query: 489 VATNVVTSITASTHLTVIGTSPHAPGSVRV-QVSMTTANVSWEPGYDGGYEQTFSVWMKR 547
                  S++    L V G  P  PG V V +++ +TA +SW P  D     +      R
Sbjct: 651 RVQTTADSVSDEAELLVRG-PPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQAR 709

Query: 548 AQFGPHDWLSLPVPPG------PSWLLVDTLEPETAYQFSVLAQNKLGT---SAFSEVVT 598
           + F    W ++   P        S + VD L P   Y+F V+A N +GT   S  S ++ 
Sbjct: 710 SPFS-LGWQTVKTVPEIITGDMESAMAVD-LNPWVEYEFRVVATNPIGTGDPSTPSRMIR 767

Query: 599 VNTLAFPITTP 609
            N  A P T P
Sbjct: 768 TNE-AVPKTAP 777



 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 160/715 (22%), Positives = 270/715 (37%), Gaps = 101/715 (14%)

Query: 28  EEPE---FVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDP 84
           +EP+   F T    + V L C+V     G P P    W + G  I             D 
Sbjct: 103 QEPDDIIFPTDSDEKKVALNCEV----RGNPVPSY-RWLRNGTEI-------------DL 144

Query: 85  EYAGRASLHDKASLRLEQVRSEDQGWYEC-------KVLMLDQQYDTFHNGSWVHLTINA 137
           E   R SL D   +      ++D G Y+C        +L  +      + G++   T +A
Sbjct: 145 ESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSA 204

Query: 138 PPTFTETPPQYIEAKEGGSITMTCTAFGN-PKPIVTWL--KEGTLLGASGKYQVSD--GS 192
                      +  +EG  + + C+   + P+ I +W+  +  + +    +  +S   G+
Sbjct: 205 -----------VSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGN 253

Query: 193 LTVTSVSREDRGAYTCRAYSIQGEA---VHTTHLLVQGP--------------PFIVSPP 235
           L ++ V   D G+Y C   +    A      T L ++                PF V+  
Sbjct: 254 LYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA 313

Query: 236 ENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKP 295
           +  TV +   AL         GN   T  W   N Y  +  +LR        L I  V+ 
Sbjct: 314 KGTTVKMECFAL---------GNPVPTITWMKVNGYIPSKARLRKS---QAVLEIPNVQL 361

Query: 296 EDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPAT 355
           +D+G Y C   NS G++          YP  V  +     +  G      C    +P  T
Sbjct: 362 DDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDT-QLDSGSPLRWECKATGKPRPT 420

Query: 356 VVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLV 415
             +W K+G PL  +  +    M +G + I    +   G Y C+  N  G +  SA  +++
Sbjct: 421 Y-RWLKNGVPLSPQSRVE---MVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKIL 476

Query: 416 LKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKH--SALPSGSL 473
              P +              +E++I C   G P P I+W+K  +  R     + LP GSL
Sbjct: 477 ASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSL 536

Query: 474 QFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANV-SWEPG 532
           +    SK D G++ C   NV  S      L+V   +       R ++++  + V + +  
Sbjct: 537 RILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAI 596

Query: 533 YDGGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSA 592
           +D   + TF  W  + Q         P+         +++  + A    ++ +N L   A
Sbjct: 597 HDASLDVTF-YWTLKGQ---------PIDFEEEGGHFESIRAQ-ASSADLMIRNILLMHA 645

Query: 593 FSEVVTVNTLAFPITTPEPLVLVTPPR----CLIANRTQQGVLLSWLPPANHSFPIDRYI 648
                 V T A  ++    L++  PP      ++   T+    LSW P A++  PI  Y 
Sbjct: 646 GRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYN 705

Query: 649 MEFR--VAERWE---LLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPS 698
           ++ R   +  W+    + + I G      A DL+    YEFRV+A       +PS
Sbjct: 706 LQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPS 760



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 89/396 (22%), Positives = 162/396 (40%), Gaps = 28/396 (7%)

Query: 134 TINAPPTFTETPPQYIEAKEGGS--ITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVS-- 189
           +++  P F + P   I   +     + + C   GNP P   WL+ GT +     Y+ S  
Sbjct: 94  SVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI 153

Query: 190 DGSLTVTSVSR-EDRGAYTCRAYSIQGEAV--HTTHLLVQGPPFIVSPPENITVNISQDA 246
           DG+  +++ S  +D G Y C A +  G  +    T        F       ++V   Q  
Sbjct: 154 DGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGV 213

Query: 247 LLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPS 306
           +L C    +   + Y+W + +   +   D + R      G L I +V+  D G Y C+  
Sbjct: 214 VLMCSPPPHSPEIIYSWVFNEFPSFVAEDSR-RFISQETGNLYISKVQTSDVGSYICLVK 272

Query: 307 NSL--GRSPSASAYLTV-------QYPARV-LNMPPVIYVPVGIHGYIRCPVDAEPPATV 356
           N++   R  S    LT+       +Y  ++ ++ P  +    G    + C     P  T+
Sbjct: 273 NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTI 332

Query: 357 VKWNKDGR-PLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLV 415
                +G  P +        ++E  ++++++A     G Y C   N+ G    S   +L 
Sbjct: 333 TWMKVNGYIPSKARLRKSQAVLEIPNVQLDDA-----GIYECRAENSRGK--NSFRGQLQ 385

Query: 416 LKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKP-SRSKHSALPSGSLQ 474
           +   P++      + + ++G  L   C A G P P   W K G P S      + +G L 
Sbjct: 386 VYTYPHWVEKLN-DTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLM 444

Query: 475 FRALSKEDHGEWECVATNVVTSITASTHLTVIGTSP 510
              +++ D G ++C+A N   +I AS  L ++ ++P
Sbjct: 445 IHNVNQSDAGMYQCLAENKYGAIYASAELKILASAP 480


>gi|28373129 contactin 5 isoform short [Homo sapiens]
          Length = 1026

 Score =  137 bits (345), Expect = 7e-32
 Identities = 156/611 (25%), Positives = 241/611 (39%), Gaps = 72/611 (11%)

Query: 33  VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
           V+ R G+ VVL C         PPP+  E     V       F  +P  V  E + R   
Sbjct: 131 VSVREGQGVVLMCS--------PPPHSPEIIYSWV-------FNEFPSFV-AEDSRRFIS 174

Query: 93  HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVH----LTINAPPTFTETPPQY 148
            +  +L + +V++ D G Y C V       +T  N   +     LT+       E  P+ 
Sbjct: 175 QETGNLYISKVQTSDVGSYICLVK------NTVTNARVLSPPTPLTLRNDGVMGEYEPKI 228

Query: 149 -------IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSRE 201
                  + A +G ++ M C A GNP P +TW+K    + +  + + S   L + +V  +
Sbjct: 229 EVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLD 288

Query: 202 DRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTY 261
           D G Y CRA + +G+      L V   P  V    +  ++        C+A   P   TY
Sbjct: 289 DAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKP-RPTY 347

Query: 262 TWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGR-SPSASAYLT 320
            W      +  Q+ ++     +++G L+I  V   D+G Y C+  N  G    SA   + 
Sbjct: 348 RWLKNGVPLSPQSRVE-----MVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKIL 402

Query: 321 VQYPARVLN-MPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMED 379
              P   LN +   I V       I C     P  T + W K  R ++  K +   ++ D
Sbjct: 403 ASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPT-ISWKKGDRAVRENKRI--AILPD 459

Query: 380 GSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELL 439
           GS+RI  A++   G Y C   N  G+      A L +K+P    + P        G  ++
Sbjct: 460 GSLRILNASKSDEGKYVCRGENVFGS--AEIIASLSVKEPTRIELTPK-RTELTVGESIV 516

Query: 440 IPCAAAGDPFPVIT--WRKVGKP---------SRSKHSALPSGSLQFRALSKEDHGEWEC 488
           + C A  D    +T  W   G+P           S  +   S  L  R +     G + C
Sbjct: 517 LNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGC 576

Query: 489 VATNVVTSITASTHLTVIGTSPHAPGSVRV-QVSMTTANVSWEPGYDGGYEQTFSVWMKR 547
                  S++    L V G  P  PG V V +++ +TA +SW P  D     +      R
Sbjct: 577 RVQTTADSVSDEAELLVRG-PPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQAR 635

Query: 548 AQFGPHDWLSLPVPPG------PSWLLVDTLEPETAYQFSVLAQNKLGT---SAFSEVVT 598
           + F    W ++   P        S + VD L P   Y+F V+A N +GT   S  S ++ 
Sbjct: 636 SPFS-LGWQTVKTVPEIITGDMESAMAVD-LNPWVEYEFRVVATNPIGTGDPSTPSRMIR 693

Query: 599 VNTLAFPITTP 609
            N  A P T P
Sbjct: 694 TNE-AVPKTAP 703



 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 160/715 (22%), Positives = 270/715 (37%), Gaps = 101/715 (14%)

Query: 28  EEPE---FVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDP 84
           +EP+   F T    + V L C+V     G P P    W + G  I             D 
Sbjct: 29  QEPDDIIFPTDSDEKKVALNCEV----RGNPVPSY-RWLRNGTEI-------------DL 70

Query: 85  EYAGRASLHDKASLRLEQVRSEDQGWYEC-------KVLMLDQQYDTFHNGSWVHLTINA 137
           E   R SL D   +      ++D G Y+C        +L  +      + G++   T +A
Sbjct: 71  ESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSA 130

Query: 138 PPTFTETPPQYIEAKEGGSITMTCTAFGN-PKPIVTWL--KEGTLLGASGKYQVSD--GS 192
                      +  +EG  + + C+   + P+ I +W+  +  + +    +  +S   G+
Sbjct: 131 -----------VSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGN 179

Query: 193 LTVTSVSREDRGAYTCRAYSIQGEA---VHTTHLLVQGP--------------PFIVSPP 235
           L ++ V   D G+Y C   +    A      T L ++                PF V+  
Sbjct: 180 LYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA 239

Query: 236 ENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKP 295
           +  TV +   AL         GN   T  W   N Y  +  +LR        L I  V+ 
Sbjct: 240 KGTTVKMECFAL---------GNPVPTITWMKVNGYIPSKARLRKS---QAVLEIPNVQL 287

Query: 296 EDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPAT 355
           +D+G Y C   NS G++          YP  V  +     +  G      C    +P  T
Sbjct: 288 DDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDT-QLDSGSPLRWECKATGKPRPT 346

Query: 356 VVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLV 415
             +W K+G PL  +  +    M +G + I    +   G Y C+  N  G +  SA  +++
Sbjct: 347 Y-RWLKNGVPLSPQSRVE---MVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKIL 402

Query: 416 LKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKH--SALPSGSL 473
              P +              +E++I C   G P P I+W+K  +  R     + LP GSL
Sbjct: 403 ASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSL 462

Query: 474 QFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANV-SWEPG 532
           +    SK D G++ C   NV  S      L+V   +       R ++++  + V + +  
Sbjct: 463 RILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAI 522

Query: 533 YDGGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSA 592
           +D   + TF  W  + Q         P+         +++  + A    ++ +N L   A
Sbjct: 523 HDASLDVTF-YWTLKGQ---------PIDFEEEGGHFESIRAQ-ASSADLMIRNILLMHA 571

Query: 593 FSEVVTVNTLAFPITTPEPLVLVTPPR----CLIANRTQQGVLLSWLPPANHSFPIDRYI 648
                 V T A  ++    L++  PP      ++   T+    LSW P A++  PI  Y 
Sbjct: 572 GRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYN 631

Query: 649 MEFR--VAERWE---LLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPS 698
           ++ R   +  W+    + + I G      A DL+    YEFRV+A       +PS
Sbjct: 632 LQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPS 686



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 89/396 (22%), Positives = 162/396 (40%), Gaps = 28/396 (7%)

Query: 134 TINAPPTFTETPPQYIEAKEGGS--ITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVS-- 189
           +++  P F + P   I   +     + + C   GNP P   WL+ GT +     Y+ S  
Sbjct: 20  SVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI 79

Query: 190 DGSLTVTSVSR-EDRGAYTCRAYSIQGEAV--HTTHLLVQGPPFIVSPPENITVNISQDA 246
           DG+  +++ S  +D G Y C A +  G  +    T        F       ++V   Q  
Sbjct: 80  DGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGV 139

Query: 247 LLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPS 306
           +L C    +   + Y+W + +   +   D + R      G L I +V+  D G Y C+  
Sbjct: 140 VLMCSPPPHSPEIIYSWVFNEFPSFVAEDSR-RFISQETGNLYISKVQTSDVGSYICLVK 198

Query: 307 NSL--GRSPSASAYLTV-------QYPARV-LNMPPVIYVPVGIHGYIRCPVDAEPPATV 356
           N++   R  S    LT+       +Y  ++ ++ P  +    G    + C     P  T+
Sbjct: 199 NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTI 258

Query: 357 VKWNKDGR-PLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLV 415
                +G  P +        ++E  ++++++A     G Y C   N+ G    S   +L 
Sbjct: 259 TWMKVNGYIPSKARLRKSQAVLEIPNVQLDDA-----GIYECRAENSRGK--NSFRGQLQ 311

Query: 416 LKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKP-SRSKHSALPSGSLQ 474
           +   P++      + + ++G  L   C A G P P   W K G P S      + +G L 
Sbjct: 312 VYTYPHWVEKLN-DTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLM 370

Query: 475 FRALSKEDHGEWECVATNVVTSITASTHLTVIGTSP 510
              +++ D G ++C+A N   +I AS  L ++ ++P
Sbjct: 371 IHNVNQSDAGMYQCLAENKYGAIYASAELKILASAP 406


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.134    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 68,336,932
Number of Sequences: 37866
Number of extensions: 4313633
Number of successful extensions: 29357
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 293
Number of HSP's successfully gapped in prelim test: 1546
Number of HSP's that attempted gapping in prelim test: 15144
Number of HSP's gapped (non-prelim): 9315
length of query: 1349
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1235
effective length of database: 13,930,794
effective search space: 17204530590
effective search space used: 17204530590
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.