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Search of human proteins with 148806928
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148806928 hypothetical protein LOC57482 [Homo sapiens]
(1233 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148806928 hypothetical protein LOC57482 [Homo sapiens] 2462 0.0
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 121 5e-27
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 119 2e-26
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 117 9e-26
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 114 7e-25
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 114 7e-25
gi|148746195 trichohyalin [Homo sapiens] 113 1e-24
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 110 8e-24
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 108 3e-23
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 107 5e-23
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 107 9e-23
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 107 9e-23
gi|116256464 hypothetical protein LOC343990 [Homo sapiens] 97 1e-19
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 94 8e-19
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 93 2e-18
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 92 2e-18
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 92 4e-18
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 92 4e-18
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 92 4e-18
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 92 4e-18
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 89 3e-17
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 89 3e-17
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 87 1e-16
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 87 1e-16
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 86 2e-16
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 86 2e-16
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 86 2e-16
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 86 3e-16
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 85 4e-16
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 85 4e-16
>gi|148806928 hypothetical protein LOC57482 [Homo sapiens]
Length = 1233
Score = 2462 bits (6380), Expect = 0.0
Identities = 1233/1233 (100%), Positives = 1233/1233 (100%)
Query: 1 MGTRAFSHDSIFIPDGGAESEQTVQAMSQDNILGKVKTLQQQLGKNIKFGQRSPNAIPMN 60
MGTRAFSHDSIFIPDGGAESEQTVQAMSQDNILGKVKTLQQQLGKNIKFGQRSPNAIPMN
Sbjct: 1 MGTRAFSHDSIFIPDGGAESEQTVQAMSQDNILGKVKTLQQQLGKNIKFGQRSPNAIPMN 60
Query: 61 KANSGEASLEEDLFLTSPMEIVTQQDIVLSDAENKSSDTPSSLSPLNLPGAGSEMEEKVA 120
KANSGEASLEEDLFLTSPMEIVTQQDIVLSDAENKSSDTPSSLSPLNLPGAGSEMEEKVA
Sbjct: 61 KANSGEASLEEDLFLTSPMEIVTQQDIVLSDAENKSSDTPSSLSPLNLPGAGSEMEEKVA 120
Query: 121 PVKPSRPKRHFSSAGTIESVNLDAIPLAIARLDNSAAKHKLAVKPKKQRVSKKHRRLAQD 180
PVKPSRPKRHFSSAGTIESVNLDAIPLAIARLDNSAAKHKLAVKPKKQRVSKKHRRLAQD
Sbjct: 121 PVKPSRPKRHFSSAGTIESVNLDAIPLAIARLDNSAAKHKLAVKPKKQRVSKKHRRLAQD 180
Query: 181 PQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKA 240
PQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKA
Sbjct: 181 PQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKA 240
Query: 241 EAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGW 300
EAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGW
Sbjct: 241 EAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGW 300
Query: 301 EDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKR 360
EDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKR
Sbjct: 301 EDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKR 360
Query: 361 QEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLS 420
QEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLS
Sbjct: 361 QEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLS 420
Query: 421 ELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPE 480
ELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPE
Sbjct: 421 ELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPE 480
Query: 481 EKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQTMPRPYTFQ 540
EKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQTMPRPYTFQ
Sbjct: 481 EKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQTMPRPYTFQ 540
Query: 541 VSSGGKQILFPKVNLSPVTPAKDTGLTAAPQEPKAPKASPVQHALPSSLSVPHTAILVTG 600
VSSGGKQILFPKVNLSPVTPAKDTGLTAAPQEPKAPKASPVQHALPSSLSVPHTAILVTG
Sbjct: 541 VSSGGKQILFPKVNLSPVTPAKDTGLTAAPQEPKAPKASPVQHALPSSLSVPHTAILVTG 600
Query: 601 AQLCGPAVNLSQIKDTACKSLLGLEEKKHAEAPAGENPPRGPGDARAGSGKAKPRQESPS 660
AQLCGPAVNLSQIKDTACKSLLGLEEKKHAEAPAGENPPRGPGDARAGSGKAKPRQESPS
Sbjct: 601 AQLCGPAVNLSQIKDTACKSLLGLEEKKHAEAPAGENPPRGPGDARAGSGKAKPRQESPS 660
Query: 661 SASALAEWASIRSRILKNAESDPRSSERDQLRPGDESTPRGRCDSRGNQRKTPPVNAKFS 720
SASALAEWASIRSRILKNAESDPRSSERDQLRPGDESTPRGRCDSRGNQRKTPPVNAKFS
Sbjct: 661 SASALAEWASIRSRILKNAESDPRSSERDQLRPGDESTPRGRCDSRGNQRKTPPVNAKFS 720
Query: 721 IMPAWQKFSDGGTETSKQSTEAESIRKRPMLGPSEETAPQPPPAGVRELGKGPEKSEMHR 780
IMPAWQKFSDGGTETSKQSTEAESIRKRPMLGPSEETAPQPPPAGVRELGKGPEKSEMHR
Sbjct: 721 IMPAWQKFSDGGTETSKQSTEAESIRKRPMLGPSEETAPQPPPAGVRELGKGPEKSEMHR 780
Query: 781 EPADTTEGCKFAKDLPSFLVPSLPYPPQKVVAHTEFTTSSDSETANGIAKPDPVMPGGEE 840
EPADTTEGCKFAKDLPSFLVPSLPYPPQKVVAHTEFTTSSDSETANGIAKPDPVMPGGEE
Sbjct: 781 EPADTTEGCKFAKDLPSFLVPSLPYPPQKVVAHTEFTTSSDSETANGIAKPDPVMPGGEE 840
Query: 841 KASPFGIKLRRTNYSLRFNCDQQAEQKKKKRHSSTGDSADAGPPAAGSARGEKEMEGVAL 900
KASPFGIKLRRTNYSLRFNCDQQAEQKKKKRHSSTGDSADAGPPAAGSARGEKEMEGVAL
Sbjct: 841 KASPFGIKLRRTNYSLRFNCDQQAEQKKKKRHSSTGDSADAGPPAAGSARGEKEMEGVAL 900
Query: 901 KHGPSLPQERKQAPSTRRDSAEPSSSRSVPVAHPGPPPASSQTPAPEHDKAANKMPLAQK 960
KHGPSLPQERKQAPSTRRDSAEPSSSRSVPVAHPGPPPASSQTPAPEHDKAANKMPLAQK
Sbjct: 901 KHGPSLPQERKQAPSTRRDSAEPSSSRSVPVAHPGPPPASSQTPAPEHDKAANKMPLAQK 960
Query: 961 PALAPKPTSQTPPASPLSKLSRPYLVELLSRRAGRPDPEPSEPSKEDQESSDRRPPSPPG 1020
PALAPKPTSQTPPASPLSKLSRPYLVELLSRRAGRPDPEPSEPSKEDQESSDRRPPSPPG
Sbjct: 961 PALAPKPTSQTPPASPLSKLSRPYLVELLSRRAGRPDPEPSEPSKEDQESSDRRPPSPPG 1020
Query: 1021 PEERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTE 1080
PEERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTE
Sbjct: 1021 PEERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTE 1080
Query: 1081 KVETAQPLWITLALQKQKGFREQQATREERKQAREAKQAEKLSKENVSVSVQPGSSSVSR 1140
KVETAQPLWITLALQKQKGFREQQATREERKQAREAKQAEKLSKENVSVSVQPGSSSVSR
Sbjct: 1081 KVETAQPLWITLALQKQKGFREQQATREERKQAREAKQAEKLSKENVSVSVQPGSSSVSR 1140
Query: 1141 AGSLHKSTALPEEKRPETAVSRLERREQLKKANTLPTSVTVEISDSAPPAPLVKEVTKRF 1200
AGSLHKSTALPEEKRPETAVSRLERREQLKKANTLPTSVTVEISDSAPPAPLVKEVTKRF
Sbjct: 1141 AGSLHKSTALPEEKRPETAVSRLERREQLKKANTLPTSVTVEISDSAPPAPLVKEVTKRF 1200
Query: 1201 STPDAAPVSTEPAWLALAKRKAKAWSDCPQIIK 1233
STPDAAPVSTEPAWLALAKRKAKAWSDCPQIIK
Sbjct: 1201 STPDAAPVSTEPAWLALAKRKAKAWSDCPQIIK 1233
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 121 bits (303), Expect = 5e-27
Identities = 91/339 (26%), Positives = 172/339 (50%), Gaps = 21/339 (6%)
Query: 209 EEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQ--RLQALERRLWEENRR 266
E+E + EE+ RRQE RE E + + Q+ E E+++L EQ ++Q E ++WE+ +
Sbjct: 266 EQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEK 325
Query: 267 QELLEEEGEGQEPPL-EAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQA 325
EE+ QE L E E+ RE++Q+ D E R E+ ERL +EER R Q
Sbjct: 326 MREQEEKMWRQEERLWEQEKQMREQEQKM------RDQEERMWEQDERLREKEERMREQE 379
Query: 326 QAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEA 385
+ +E + EE+ E ++ EEE E+ ++ +++E WE+ E++E + Q PE
Sbjct: 380 KMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ-EEKEWQQQRLPEQ 438
Query: 386 LEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQ-----LSELLNDFEERL-EDQERLKPE 439
E+ E + E+E+ E+EE E+ GQ E + + E+++ E +E+++ +
Sbjct: 439 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 498
Query: 440 GQREHSEEPGICEEQ---NPEAERRREQQ--GRSGDFQGADRPGPEEKREEGDTEPLLKQ 494
Q+ +E + E+ + ER REQ+ + + ++ E++++ D E +++
Sbjct: 499 EQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMRE 558
Query: 495 EGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQTM 533
E + + + +E EQ K++E + ++ + M
Sbjct: 559 EERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKM 597
Score = 114 bits (286), Expect = 4e-25
Identities = 105/395 (26%), Positives = 190/395 (48%), Gaps = 36/395 (9%)
Query: 168 QRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQED- 226
+R+ +K R+ + ++ E + + E + EEE + EE+ ++QE+
Sbjct: 366 ERLREKEERMRE----QEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEEN 421
Query: 227 YWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPL----- 281
W + E + ++Q+ +++ E++++Q E ++WE+ + +EE GQE +
Sbjct: 422 MWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR-DQEEMWGQEKKMWRQEK 480
Query: 282 ----EAERAPREEQQRSLEAPGWEDAER--------REREER----ERLEAEEERRRLQA 325
E + +EE+ R E W+ ER RE+EER +++ +EE+ R +
Sbjct: 481 MREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEK 540
Query: 326 QAQAEERRR--LEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEE-LEQQEAEVQGP 382
+ Q +E++ EE R EER R+ E++ R EE+ R++EE+ + EE + +QE ++
Sbjct: 541 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQ 600
Query: 383 PEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQE---RLKPE 439
E ++E E EE+ +EEE+ E+ + E + + EE++ +QE R + E
Sbjct: 601 EEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEE 660
Query: 440 GQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVE 499
RE E+ EE+ E E + + Q Q G EEK G E + QE +
Sbjct: 661 KMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKM-WGQEEKMWGQEEKM- 718
Query: 500 AAQPPVERKEAAALEQGRKVEELRWQEVDERQTMP 534
Q + KE +Q K++E R E +ER + P
Sbjct: 719 WGQEEMREKEERIRDQKEKMQE-RLPEHEERCSEP 752
Score = 97.8 bits (242), Expect = 6e-20
Identities = 88/374 (23%), Positives = 175/374 (46%), Gaps = 36/374 (9%)
Query: 166 KKQRVSKKHRRLAQDPQHEQGGL-ESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQ 224
K +R K+ R ++ + ++ L E + +Q E + E+E + EE+ RQ
Sbjct: 277 KMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQ 336
Query: 225 EDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAE 284
E+ E E + + Q EQ+++ E R+WE++ R EE QE E E
Sbjct: 337 EERLWEQEKQMREQ-----------EQKMRDQEERMWEQDERLREKEERMREQEKMWEQE 385
Query: 285 RAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARL-EE 343
+EE++ + E RE+ E+++ +EE Q + + +++R E+ +L E+
Sbjct: 386 EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ 445
Query: 344 RRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGE 403
+ QE+EE +E K +++EE G E+ ++ +++ + + E E R E++ +
Sbjct: 446 EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ 505
Query: 404 EEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQR--------EHSEEPGICEEQN 455
EE W + E L + EER+ +Q+++ + ++ E ++ EE+
Sbjct: 506 EERM-------W--EQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKM 556
Query: 456 PEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQ 515
E ER RE++ + + + R E+ +E+ E + +QE + + ++ +E EQ
Sbjct: 557 REEERMREREKKMREEEEMMREQEEKMQEQ--EEKMREQEEKMWEQEEKMQEQEEKMWEQ 614
Query: 516 GRKVEELRWQEVDE 529
EE W++ +E
Sbjct: 615 ----EEKMWEQEEE 624
Score = 87.4 bits (215), Expect = 7e-17
Identities = 83/357 (23%), Positives = 162/357 (45%), Gaps = 47/357 (13%)
Query: 206 TWHEEEPN---PLDSEEERRRQEDYWREL-EAKCKRQKAEAAEKRRLEEQRLQALERRLW 261
TWH++ L E + E Y + + K++ AE EK RL E ++ +
Sbjct: 152 TWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVK 211
Query: 262 EENRRQE------------LLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERRERE 309
E R+ E L+EE QE L + E++ R E W ER +
Sbjct: 212 ELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQ----EKKIRKQEEKMWRQEERLREQ 267
Query: 310 ERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGW 369
E + E EE+ RR +E+R E++ L E+ ++ E+ + E+ ++ +E+E + W
Sbjct: 268 EGKMREQEEKMRR-------QEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMW 320
Query: 370 EE---LEQQEAEVQGPPEALEETGEGRRGAE------EEDLGEEEEEGQAHLEDWRGQLS 420
E+ + +QE ++ E L E + R E EE + E++E + E R Q
Sbjct: 321 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQ-- 378
Query: 421 ELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPE 480
E + + EE+++++ER++ E +++ EE EQ + +++ E + + + PE
Sbjct: 379 EKMWEQEEKMQEEERIR-EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPE 437
Query: 481 EKREEGDTEPLLKQEGPVEAAQPPV--------ERKEAAALEQGRKVEELRWQEVDE 529
+K + + E + +QE + + + + K+ E+ R+ E+ W++ ++
Sbjct: 438 QKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 494
Score = 77.8 bits (190), Expect = 6e-14
Identities = 54/232 (23%), Positives = 112/232 (48%), Gaps = 12/232 (5%)
Query: 158 KHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDS 217
+ ++ + K + +K R + + E+ + + + E + EEE +
Sbjct: 520 EERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQ 579
Query: 218 EEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQ 277
EE+ + QE+ RE E K Q+ EK + +E+++ E ++WE+ ++ E+E
Sbjct: 580 EEKMQEQEEKMREQEEKMWEQE----EKMQEQEEKMWEQEEKMWEQEEEDKMQEQE---- 631
Query: 278 EPPLEAERAPREEQQRSLE-APGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLE 336
E E E +E++++ E + E + RE+ E+++ +EE+ R Q + + ++
Sbjct: 632 EMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMR 691
Query: 337 EDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEE 388
E EE+ R +EE+ EE +EE+ G EE+ ++E ++ E ++E
Sbjct: 692 EQ---EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQE 740
Score = 73.9 bits (180), Expect = 9e-13
Identities = 64/248 (25%), Positives = 115/248 (46%), Gaps = 37/248 (14%)
Query: 168 QRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEP-----NPLDSEEERR 222
+R+ +K R+ + + Q + R ++ ++K TW +EE + E++ R
Sbjct: 514 ERLREKEERMREQKKMWQQEEKMR---EEKKTQEQEKKTWDQEEKMREEERMREREKKMR 570
Query: 223 RQEDYWRELEAKCKRQKA---EAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEP 279
+E+ RE E K + Q+ E EK +E+++Q E ++WE+ + EEE + QE
Sbjct: 571 EEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQ 630
Query: 280 PLEAERAPREEQQRSLEAPGWEDAER------REREERERLEAEEERRRLQA---QAQAE 330
E +EE+ + E WE E+ + RE+ E+++ +EE+ R Q Q Q E
Sbjct: 631 --EEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEE 688
Query: 331 ERRRLEEDARLEERRRQEEEEGRCAEE---------------LKRQEEEEAEGWEELEQQ 375
+ R EE R +E + +EE +E ++ Q+E+ E E E++
Sbjct: 689 KMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEER 748
Query: 376 EAEVQGPP 383
+E PP
Sbjct: 749 CSEPCLPP 756
Score = 59.3 bits (142), Expect = 2e-08
Identities = 46/202 (22%), Positives = 100/202 (49%), Gaps = 19/202 (9%)
Query: 166 KKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQE 225
+++R+ ++ +++ ++ + + E ++ E+K W +EE E+ ++E
Sbjct: 558 EEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEK-MWEQEEKMQEQEEKMWEQEE 616
Query: 226 DYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAER 285
W E E + K Q+ E E +E+++Q E ++WE+ + EE+ QE ++ +
Sbjct: 617 KMW-EQEEEDKMQEQE--EMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQE 673
Query: 286 APREEQQRSLEAPGWEDAER------REREER-----ERLEAEEERRRLQAQAQAEERRR 334
EQ+ ++ G E+ R R +EE+ E++ +EE+ Q + + +E R
Sbjct: 674 EKMREQEEKMQ--GQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERI 731
Query: 335 LEEDARLEERRRQEEEEGRCAE 356
++ +++ER + EE RC+E
Sbjct: 732 RDQKEKMQERLPEHEE--RCSE 751
Score = 51.2 bits (121), Expect = 6e-06
Identities = 78/343 (22%), Positives = 140/343 (40%), Gaps = 49/343 (14%)
Query: 216 DSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALER-RLWEENRRQELLEEEG 274
+ + + QE RE+EA+ + +K LE + + R +E+ E + G
Sbjct: 72 EKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESKDLAG 131
Query: 275 EGQEPPLEAERAPREEQQRSLEAPG-WEDAERREREE----RERLEAEEERRRLQAQAQA 329
L E QR+L A W R EE R+ L E R + +
Sbjct: 132 R-----LHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELK 186
Query: 330 EERRRLEEDARLEERRRQEEEEGRCAEELKRQEEE-------------EAEGW---EELE 373
++ L+E RL E + E + +ELKR+ E + E W EEL
Sbjct: 187 KKNAELQEKLRLAESEKSEIQLN--VKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELR 244
Query: 374 QQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSEL------LNDFE 427
+QE +++ E + +EE L E+E + + E R Q L L + E
Sbjct: 245 EQEKKIRKQEEKMWR--------QEERLREQEGKMREQEEKMRRQEKRLREQEKELREQE 296
Query: 428 ERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGD 487
+ L +Q++L+ + ++ +E + E++ E+ REQ+ + ++ +R +EK+
Sbjct: 297 KELREQKKLREQEEQMQEQEEKMWEQE----EKMREQEEKM--WRQEERLWEQEKQMREQ 350
Query: 488 TEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDER 530
+ + QE + + KE EQ + E+ + +ER
Sbjct: 351 EQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEER 393
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 119 bits (298), Expect = 2e-26
Identities = 91/345 (26%), Positives = 179/345 (51%), Gaps = 26/345 (7%)
Query: 209 EEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQ--RLQALERRLWEENRR 266
E+E + EE+ RQE RE E + + Q+ E E++ L EQ ++Q E ++WE+ +
Sbjct: 304 EQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEK 363
Query: 267 QELLEEEGEGQEPPL-EAERAPREEQQ--RSLEAPGWEDAER-REREER--------ERL 314
EE+ QE L E E+ RE++Q R E WE ER RE+EER E++
Sbjct: 364 MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQV 423
Query: 315 EAEEERRRLQAQAQA--EERRRLEEDARLEER-RRQEEEEGRCAEELKRQEEEEAEGWEE 371
E E +++Q Q + ++ +++E+ R+ ER ++ EEE E+ ++ +++E WE+
Sbjct: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 483
Query: 372 LEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLE 431
E++E + Q PE E+ E + E+E+ E+EE E+ GQ ++ E+ E
Sbjct: 484 -EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ-EKMRE 541
Query: 432 DQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGD----FQGADRPGPEEKREEGD 487
++++ + ++ +E + +++ ++ +EQ+ ++ D + +R EK+ +
Sbjct: 542 QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 601
Query: 488 TEPLLKQEGPVEAAQPPVERKEAAALEQGRKV---EELRWQEVDE 529
E + +QE ++ + ++ +E EQ K+ EE W++ ++
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEK 646
Score = 112 bits (280), Expect = 2e-24
Identities = 87/366 (23%), Positives = 181/366 (49%), Gaps = 33/366 (9%)
Query: 166 KKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQE 225
KK + +K R ++ E+ + R +K EEE E+ ++++E
Sbjct: 430 KKMQEQEKKTRDQEEKMQEEERIRER-----------EKKMREEEETMREQEEKMQKQEE 478
Query: 226 DYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAER 285
+ W + E + ++Q+ +++ E++++Q E ++WE+ + +EE GQE ++
Sbjct: 479 NMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR-DQEEMWGQE-----KK 532
Query: 286 APREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERR 345
R+E+ R E WE E + R++ +++ +EER + Q Q ++ EE R EER
Sbjct: 533 MWRQEKMREQEDQMWEQ-EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERM 591
Query: 346 RQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEE 405
R+ E++ R EE+ R++EE+ + EE Q++ E E + E + +EE + E+E
Sbjct: 592 REREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 651
Query: 406 EE--GQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRRE 463
E+ Q L + + +L E E++++QE+++ + ++ +E E++ E E++
Sbjct: 652 EKMWEQQRLPEQKEKLWE-----HEKMQEQEKMQEQEEKIWEQEK--MEKKTQEQEKKTW 704
Query: 464 QQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKV---E 520
Q + + + EK+ + E + +QE ++ + ++ +E EQ K+ E
Sbjct: 705 DQEKMREEESMRE---REKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQE 761
Query: 521 ELRWQE 526
E W++
Sbjct: 762 EKMWEQ 767
Score = 104 bits (259), Expect = 6e-22
Identities = 92/337 (27%), Positives = 170/337 (50%), Gaps = 30/337 (8%)
Query: 218 EEERRRQEDYWRELEAKCKRQKAEA---AEKRRLEEQRLQALERRLWEENRRQELLEEEG 274
+EE RQE+ RE E K ++Q+ + E+ R +E +++ E ++W + +R E+E
Sbjct: 271 QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKEL 330
Query: 275 EGQEPPLEAERAPRE--EQQRSLEAPGWEDAER-REREER-----ERLEAEEERRRLQAQ 326
QE L ++ RE EQ + E WE E+ RE+EE+ ERL +E++ R Q Q
Sbjct: 331 REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 390
Query: 327 AQAEERRRL-EEDARL---EERRRQEE----EEGRCAEELKRQEEE-EAEGWEELEQQEA 377
++ R+ E+D RL EER R++E + + EE K QE+E + EE Q+E
Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE 450
Query: 378 EVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLK 437
++ + + E E R EE+ +EE + ++W+ Q L + +E+L +QE+++
Sbjct: 451 RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ---RLPEQKEKLWEQEKMQ 507
Query: 438 PEGQREHSEEPGICEEQ---NPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQ 494
+ ++ +E I +++ E + R+++ R + D+ +E++ + + Q
Sbjct: 508 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE----DQMWEQEEKMRDQEQKMWDQ 563
Query: 495 EGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQ 531
E +E E+K E+ R+ E +R +E R+
Sbjct: 564 EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMRE 600
Score = 102 bits (254), Expect = 2e-21
Identities = 96/401 (23%), Positives = 188/401 (46%), Gaps = 45/401 (11%)
Query: 166 KKQRVSKKHRRLAQDP----QHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEER 221
++QR+ ++ +L + Q E+ + DQ G++K W +E+ + E++
Sbjct: 489 QQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR--EQEDQM 546
Query: 222 RRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPL 281
QE+ R+ E K Q+ +K + +E++ E ++ EE R +E ++ E +E
Sbjct: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 606
Query: 282 EAERAPREEQQRSLEAPG--WEDAERREREERERLEAEE-----ERRRLQAQAQAEERRR 334
E E +E++++ E WE E+ + +E + E EE E + + Q E++ +
Sbjct: 607 EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEK 666
Query: 335 LEEDARLEERRRQEEEEGRCAEELKRQ---EEEEAEGWEELEQQEAEVQGPPEALEETGE 391
L E +++E+ + +E+E + E+ K + +E+E + W++ + +E E E
Sbjct: 667 LWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRERE------- 719
Query: 392 GRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQR--------- 442
++ EEE++ E+EE E+ + E + + EE++ +QE E QR
Sbjct: 720 -KKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 778
Query: 443 EH---SEEPGICEEQNPEAERRREQQGRSGDFQGADRP--GPEEK---REE---GDTEPL 491
EH E+ I E++ ++ + +G+ +G + G EEK +EE G E +
Sbjct: 779 EHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKM 838
Query: 492 LKQEGPVEAAQPPVERKEAAALEQGRKVEE-LRWQEVDERQ 531
QE + + +E K E+ R+ EE +R QE R+
Sbjct: 839 WGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMRE 879
Score = 100 bits (248), Expect = 1e-20
Identities = 88/333 (26%), Positives = 155/333 (46%), Gaps = 36/333 (10%)
Query: 202 EDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLW 261
++K TW +EE + EE R +E RE E + Q+ EK + +E+++Q E ++W
Sbjct: 574 QEKKTWDQEEK--MREEERMREREKKMREEEEMMREQE----EKMQEQEEKMQEQEEKMW 627
Query: 262 EENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPG--WEDAERREREERERLEA--- 316
E+ + + EE+ QE + + EQQR E WE + +E+E+ + E
Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687
Query: 317 EEERRRLQAQAQA-----EERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEA----- 366
E+E+ + Q Q +E+ R EE R E++ +EEEE +E K QE+EE
Sbjct: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 747
Query: 367 -EGWE------ELEQQEAEVQGPPEALEETGEGRRGAE-------EEDLGEEEEEGQAHL 412
E WE E E++ E Q PE E+ E + E EE + ++EE+ +
Sbjct: 748 EEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQE 807
Query: 413 EDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQ 472
E RGQ ++ E+ +E++ + ++ +E + ++ E+ + Q+ + + Q
Sbjct: 808 EKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMRE-Q 866
Query: 473 GADRPGPEEKREEGDTEPLLKQEGPVEAAQPPV 505
G EEK E + + ++E PP+
Sbjct: 867 EEKMRGQEEKMREQEEKMRGQEEKIYCVGSPPI 899
Score = 98.6 bits (244), Expect = 3e-20
Identities = 80/360 (22%), Positives = 173/360 (48%), Gaps = 32/360 (8%)
Query: 202 EDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRL-------EEQRLQ 254
+++ W ++E + EE R QE W ++E + +K + EK+ EE+R++
Sbjct: 395 QEERMWEQDE-RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
Query: 255 ALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPG--WEDAERREREER- 311
E+++ EE EE+ + QE + + +QQR E WE + +E+EE+
Sbjct: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
Query: 312 ----ERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQE----E 363
E++ +EE + + +E+ R +ED E+ + ++E + ++ +R E E
Sbjct: 514 WEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQE 573
Query: 364 EEAEGW---------EELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLED 414
+E + W E + ++E +++ E + E E + E+E+ +E+EE E+
Sbjct: 574 QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE--KMQEQEEKMQEQEEKMWEQEE 631
Query: 415 WRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICE-EQNPEAERRREQQGRSGDFQG 473
+ E + + EE++ +QE E QR ++ + E E+ E E+ +EQ+ + + +
Sbjct: 632 KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEK 691
Query: 474 ADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQTM 533
++ E++++ D E +++E + + + +E EQ K++E + ++ + M
Sbjct: 692 MEKKTQEQEKKTWDQEK-MREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEM 750
Score = 98.2 bits (243), Expect = 4e-20
Identities = 78/311 (25%), Positives = 152/311 (48%), Gaps = 14/311 (4%)
Query: 158 KHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDS 217
+ ++ + KK R ++ R ++ EQ +Q E + E+E +
Sbjct: 588 EERMREREKKMREEEEMMREQEEKMQEQ----EEKMQEQEEKMWEQEEKMQEQEEKMWEQ 643
Query: 218 EEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQ-RLQALERRLWEENRRQELLEEEGEG 276
EE+ QE+ E + + QK + E +++EQ ++Q E ++WE QE +E++ +
Sbjct: 644 EEKMWEQEEKMWE-QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWE----QEKMEKKTQE 698
Query: 277 QEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRL- 335
QE + REE+ + E RE+ E+++ +EE+ + Q + E+ ++
Sbjct: 699 QEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMW 758
Query: 336 EEDARLEERRRQEEEEGRCAEELKRQEEEEA-EGWEELEQQEAEVQGPPEALEETGEGRR 394
E++ ++ E++R E++ + E K QE+E+ E E++ QE +++G E + E R
Sbjct: 759 EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR 818
Query: 395 GAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQ 454
G EE+ G+EE+ + W GQ ++ EE++E++ + + E RE E+ EE+
Sbjct: 819 GQEEKMWGQEEKMWGQEEKMW-GQEEKMWGQ-EEKMEEKMQGQEEKMREQEEKMRGQEEK 876
Query: 455 NPEAERRREQQ 465
E E + Q
Sbjct: 877 MREQEEKMRGQ 887
Score = 97.8 bits (242), Expect = 6e-20
Identities = 100/449 (22%), Positives = 200/449 (44%), Gaps = 55/449 (12%)
Query: 108 LPGAGSEMEEKVAPVKPSRPKRHFSSAGTIESVNLDAIPLAIARLDNSAAKHKLAVKPKK 167
LP A SE E VK + K + + V + + + R + + + ++ ++
Sbjct: 234 LPLAESEKSEIQLNVKELKRKLERAKF-LLPQVQTNTLQEEMWRQEEELREQEKKIRKQE 292
Query: 168 QRVSKKHRRLAQDP-----QHEQGGLESRPCLDQNGHPGE------DKPTWHEEEPNPLD 216
+++ ++ RL + Q E+ + + +Q E ++ E+E +
Sbjct: 293 EKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQE 352
Query: 217 SEEERRRQEDYWRELEAKCKRQKA---EAAEKRRLEEQRLQALERRLWEENRRQELLEEE 273
EE+ QE+ RE E K RQ+ E ++ R +EQ+++ E R+WE++ R EE
Sbjct: 353 QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEER 412
Query: 274 GEGQEPPLEA-------------ERAPREEQQRSLEAPGWEDAERREREERERLEAEEER 320
QE E E+ R+++++ E + E++ REE E + +EE+
Sbjct: 413 MREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEK 472
Query: 321 RRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQ 380
+ Q + E+ + + RL E++ + E+ E+++ QEE+ E E++ QE
Sbjct: 473 MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ----EKMQEQEEKIWEQEEKIRDQE---- 524
Query: 381 GPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEG 440
E G+ ++ +E + E+ ED + E + D E+++ DQE +
Sbjct: 525 ------EMWGQEKKMWRQEKMREQ--------EDQMWEQEEKMRDQEQKMWDQEERMEKK 570
Query: 441 QREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEA 500
+E ++ EE+ E ER RE++ + + + R E+ +E+ E + +QE +
Sbjct: 571 TQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ--EEKMQEQEEKMWE 628
Query: 501 AQPPVERKEAAALEQGRKV---EELRWQE 526
+ ++ +E EQ K+ EE W++
Sbjct: 629 QEEKMQEQEEKMWEQEEKMWEQEEKMWEQ 657
Score = 79.3 bits (194), Expect = 2e-14
Identities = 81/351 (23%), Positives = 162/351 (46%), Gaps = 48/351 (13%)
Query: 213 NPLDSEEERRRQEDYWRELEAKCKRQKAEAAE--------KRRLEEQRL---QALERRLW 261
N + +EE +++ EL+ K ++E +E KR+LE + Q L
Sbjct: 216 NTITNEELKKKNA----ELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ 271
Query: 262 EENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERR 321
EE RQE EE QE + R E+ R E ++ + RE+E E++ +E+R
Sbjct: 272 EEMWRQE---EELREQEKKI---RKQEEKMWRQEERLREQEGKMREQE--EKMWRQEKRL 323
Query: 322 RLQAQAQAEERRRLEEDARLEERRRQ-EEEEGRCAEELKRQEEEEAEGW---EELEQQEA 377
R Q + E+ + L E L E+ Q +E+E + E+ ++ E+E + W E L +QE
Sbjct: 324 REQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 383
Query: 378 EVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWR-----------GQLSELLNDF 426
+++ + + + E R ++E L E+EE + + W + + D
Sbjct: 384 QMREQEQKMRDQ-EERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQ 442
Query: 427 EERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEG 486
EE+++++ER++ E +++ EE EQ + +++ E + + + PE+K +
Sbjct: 443 EEKMQEEERIR-EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW 501
Query: 487 DTEPLLKQEGPVEAAQPPV--------ERKEAAALEQGRKVEELRWQEVDE 529
+ E + +QE + + + + K+ E+ R+ E+ W++ ++
Sbjct: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 552
Score = 78.6 bits (192), Expect = 3e-14
Identities = 62/236 (26%), Positives = 114/236 (48%), Gaps = 23/236 (9%)
Query: 181 PQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERR-------RQEDYWRELEA 233
P+ ++ E +Q +++ W +E+ E+E++ R+E+ RE E
Sbjct: 661 PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK 720
Query: 234 KCKRQKA---EAAEKRRLEEQRLQALERRLWEENRRQ-ELLEEEGEGQEPPLEAERAPRE 289
K + ++ E EK + +E+++Q E +WE+ + E E+ E Q P + E+
Sbjct: 721 KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 780
Query: 290 EQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEE 349
E+ + E WE E+ R++ E++ +EE+ R Q E+ R EE +E + +
Sbjct: 781 EKMQEQEKI-WEQEEKM-RDQEEKMRGQEEKMR----GQEEKMRGQEEKMWGQEEKMWGQ 834
Query: 350 EEGRCAEELK-----RQEEEEAEGWEE-LEQQEAEVQGPPEALEETGEGRRGAEEE 399
EE +E K + EE+ +G EE + +QE +++G E + E E RG EE+
Sbjct: 835 EEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
Score = 72.4 bits (176), Expect = 2e-12
Identities = 79/327 (24%), Positives = 150/327 (45%), Gaps = 36/327 (11%)
Query: 229 RELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPR 288
R L A R K L ++R AL L+ R + EE + + L+ E+ P
Sbjct: 183 RALSAVSTRHKKADRYIEELTKER-DALSLELY----RNTITNEELKKKNAELQ-EKLPL 236
Query: 289 EEQQRSLEAPGWEDAERREREERERLE-AEEERRRLQAQAQAEERRRLEEDARLEER--R 345
E ++S + + +E + +LE A+ ++Q EE R EE+ R +E+ R
Sbjct: 237 AESEKS-------EIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIR 289
Query: 346 RQEEEEGRCAEELKRQE----EEEAEGWEE---LEQQEAEVQGPPEALEETGEGRRGAEE 398
+QEE+ R E L+ QE E+E + W + L +QE E++ + L E E R +E
Sbjct: 290 KQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELRE--QE 347
Query: 399 EDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEE----- 453
E + E+EE+ E R Q ++ E E +++++ + Q+ +E + E+
Sbjct: 348 EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLR 407
Query: 454 QNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAAL 513
+ E R +E+ + ++ E++++ D E +++E + + + +E
Sbjct: 408 EKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMR 467
Query: 514 EQGRKV---EELRWQEVD---ERQTMP 534
EQ K+ EE W++ + ++Q +P
Sbjct: 468 EQEEKMQKQEENMWEQEEKEWQQQRLP 494
Score = 50.4 bits (119), Expect = 1e-05
Identities = 41/191 (21%), Positives = 83/191 (43%), Gaps = 15/191 (7%)
Query: 164 KPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRR 223
+ KK R ++ R ++ EQ +Q E + E+E + + +
Sbjct: 718 REKKMREEEEMMREQEEKMQEQ----EEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQ 773
Query: 224 QEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEA 283
+E W + + + + E EK R +E++++ E ++ + + EE+ GQE +
Sbjct: 774 KEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWG 833
Query: 284 ERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEE 343
+ EE+ E W E+ E E+++ +EE+ R Q + + ++ E EE
Sbjct: 834 Q----EEKMWGQEEKMWGQEEKME----EKMQGQEEKMREQEEKMRGQEEKMREQ---EE 882
Query: 344 RRRQEEEEGRC 354
+ R +EE+ C
Sbjct: 883 KMRGQEEKIYC 893
Score = 33.5 bits (75), Expect = 1.3
Identities = 36/179 (20%), Positives = 75/179 (41%), Gaps = 11/179 (6%)
Query: 999 EPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPE 1058
E E +E +E + EE+ ++ ++ E E+ LP Q+EK + +
Sbjct: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPE-QKEKLWEHEK 672
Query: 1059 AGRKEKPMLQSRHSLDGSKLTEKV-ETAQPLWITLALQKQKGFREQQAT-REERKQAREA 1116
+EK Q + K+ +K E + W +++++ RE++ REE + RE
Sbjct: 673 MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMRE- 731
Query: 1117 KQAEKLSKENVSVSVQ------PGSSSVSRAGSLHKSTALPEEKRPETAVSRLERREQL 1169
Q EK+ ++ + Q + + + LPE+K +++ +E++
Sbjct: 732 -QEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKI 789
Score = 30.8 bits (68), Expect = 8.3
Identities = 25/107 (23%), Positives = 51/107 (47%), Gaps = 8/107 (7%)
Query: 1023 ERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKV 1082
ER+ + R+EEE E++ Q+EK + E +++ +Q + + +
Sbjct: 593 EREKKMREEEEMMREQEEKMQE----QEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMW 648
Query: 1083 ETAQPLWITLAL--QKQKGFREQQATREERKQAREAK--QAEKLSKE 1125
E + +W L QK+K + ++ +E+ Q +E K + EK+ K+
Sbjct: 649 EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKK 695
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 117 bits (292), Expect = 9e-26
Identities = 117/376 (31%), Positives = 169/376 (44%), Gaps = 27/376 (7%)
Query: 168 QRVSKKHRRLAQDPQ-HEQGGLESRPCLDQNGHPGEDKPTWHE--EEPNPLDSEEERRRQ 224
+R + + LA+ + ++ G E + GH E E EE + EEE R+
Sbjct: 687 ERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDRE 746
Query: 225 EDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAE 284
E+ +E E K + + E +R EE + ER EE +E ++GEG+E E
Sbjct: 747 EEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEE--GDQGEGEEEETEG- 803
Query: 285 RAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEER 344
R +E+ +E E+ + EE E E EEE + + EE E+ E +
Sbjct: 804 RGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEE------EGEGEEEEGEGEEEEGEGK 857
Query: 345 RRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGE- 403
+E EEG EE EE E EG EE + E E +G E EE GEG EEE GE
Sbjct: 858 GEEEGEEGEGEEE---GEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGE--GEEEGEGEG 912
Query: 404 EEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRRE 463
EEEEG+ E+ G+ E + EE + E + EG+ E E G EE E E E
Sbjct: 913 EEEEGEGKGEE-EGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGE 971
Query: 464 QQGRSGDFQGADRPG-----PEEKREEGDTEPLLKQEGPVEAAQP---PVERKEAAALEQ 515
+G G+ +G + G EE EEG+ E ++EG E + VE + +
Sbjct: 972 GEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGE 1031
Query: 516 GRKVEELRWQEVDERQ 531
G EE +E +ER+
Sbjct: 1032 GEGEEEEGEEEGEERE 1047
Score = 109 bits (273), Expect = 1e-23
Identities = 109/364 (29%), Positives = 162/364 (44%), Gaps = 33/364 (9%)
Query: 166 KKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQE 225
++Q+ ++ + ++ + E+GG E ++G E++ EEE + +EE +E
Sbjct: 710 QEQKEREQGHQKERNQEMEEGGEE------EHGEGEEEEGDREEEEEKEGEGKEEGEGEE 763
Query: 226 DYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAER 285
+ + +R+K E A K E+ E E R E EE GE + +E +
Sbjct: 764 VEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGK 823
Query: 286 APREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERR 345
REE++ E G E+ E EE E EEE + + + EE EE E
Sbjct: 824 GEREEEEE--EGEGEEEEGEGEEEEGE---GEEEEGEGKGEEEGEEGEGEEEGEEGEGEG 878
Query: 346 RQEEEEGRCAEELK---RQEEEEAEGWEELEQQ--EAEVQGPPEALEETGEGRRGAEEED 400
+EE EG EE + +EE E EG EE E + E E +G E E GEG G EEE
Sbjct: 879 EEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGE-GEEEEG 937
Query: 401 LGEEEE---EGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPE 457
GE E+ EG+ +W G+ E + EE E + EG+ E EE G E + E
Sbjct: 938 EGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGE---EGEGEGEEEEGEGEGEEEE 994
Query: 458 AERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGR 517
E E++G G EE EG+ E + EG VE + E +E E+G
Sbjct: 995 GEEEGEEEGE----------GEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGE 1044
Query: 518 KVEE 521
+ E+
Sbjct: 1045 EREK 1048
Score = 106 bits (265), Expect = 1e-22
Identities = 107/355 (30%), Positives = 159/355 (44%), Gaps = 32/355 (9%)
Query: 179 QDPQHEQGGLESRPCLDQNGHPGE-DKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKR 237
QD + E+G E + PGE +K +EE D EE+ +++ + + E +
Sbjct: 670 QDEEREKG--EKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEM 727
Query: 238 QKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEA 297
++ E EE EE R+E E+EGEG+E E E E ++ E
Sbjct: 728 EEGGEEEHGEGEE-----------EEGDREEEEEKEGEGKEEG-EGEEVEGEREKEEGER 775
Query: 298 PGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEE---RRRQEEEEGRC 354
E A + E+ E E + E E + + + +E E +EE R +EEEEG
Sbjct: 776 KKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEG 835
Query: 355 AEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEE-EGQAHLE 413
EE EEEE EG E++E E +G E E GE G E E GEEEE EG+ E
Sbjct: 836 EEEEGEGEEEEGEG----EEEEGEGKGEEEGEEGEGE-EEGEEGEGEGEEEEGEGEGEEE 890
Query: 414 -DWRGQLSELLNDFEERLE---DQERLKPEGQREHSEEPGICEEQNPEAE---RRREQQG 466
+ G+ E + EE E ++E + +G+ E E G EE+ E E E +
Sbjct: 891 GEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEE 950
Query: 467 RSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEE 521
G+++G + G E EEG+ E + EG E + E +E E+G + E
Sbjct: 951 EEGEWEGEEEEGEGEGEEEGEGEG-EEGEGEGEEEEGEGEGEEEEGEEEGEEEGE 1004
Score = 103 bits (258), Expect = 8e-22
Identities = 88/274 (32%), Positives = 135/274 (49%), Gaps = 21/274 (7%)
Query: 219 EERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQE 278
EE ++W++ E R+K E +K R E +R E+ L E ++E + +GE QE
Sbjct: 660 EEGSSGAEHWQDEE----REKGE-KDKGRGEMERPGEGEKELAE---KEEWKKRDGEEQE 711
Query: 279 PPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEE---RRRL 335
E E+ ++E+ + +E G E+ E EE +R E EE+ + + + EE R
Sbjct: 712 QK-EREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREK 770
Query: 336 EEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRG 395
EE R +E R +EE+G + EEEE EG E +++ EV+G E G+G R
Sbjct: 771 EEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEG---GEVEEGKGERE 827
Query: 396 AEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQN 455
EEE+ EEEEG+ E+ G+ E E ++E + EG+ E E G EE+
Sbjct: 828 EEEEEGEGEEEEGEGEEEEGEGEEEE-----GEGKGEEEGEEGEGEEEGEEGEGEGEEEE 882
Query: 456 PEAERRREQQGRSGDFQGADRPGPEEKREEGDTE 489
E E E +G G+ + + G EE EG+ E
Sbjct: 883 GEGEGEEEGEG-EGEEEEGEGEGEEEGEGEGEEE 915
Score = 100 bits (249), Expect = 9e-21
Identities = 102/377 (27%), Positives = 161/377 (42%), Gaps = 21/377 (5%)
Query: 164 KPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRR 223
+ K++ KK R ++ + E+ G + ++ GE+K E E ++ + R
Sbjct: 768 REKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGERE 827
Query: 224 QEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEA 283
+E+ E E + + + E E EE+ E E +E E EGEG+E E
Sbjct: 828 EEE--EEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEG 885
Query: 284 E---RAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDAR 340
E E ++ E G E+ E EE + EEE + + + EE ED
Sbjct: 886 EGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGE 945
Query: 341 LEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEE-E 399
E + E EG EE + + EEE EG E +E E +G E E GE G EE E
Sbjct: 946 GEGEEEEGEWEGE-EEEGEGEGEEEGEG----EGEEGEGEGEEEEGEGEGEEEEGEEEGE 1000
Query: 400 DLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAE 459
+ GE EEEG+ E+ E + E +E +E + EG+ E EE G E+ E E
Sbjct: 1001 EEGEGEEEGEGEGEE------EEEGEVEGEVEGEEG-EGEGEEEEGEEEGEEREKEGEGE 1053
Query: 460 RRREQQGRSGDFQGADRPGPEEKREEGDTE---PLLKQEGPVEAAQPPVERKEAAALEQG 516
R + + +G + EE+ E D E + K +G V+ + +K++ QG
Sbjct: 1054 ENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQG 1113
Query: 517 RKVEELRWQEVDERQTM 533
E+ V ++ +
Sbjct: 1114 NGKEQRSKMPVQSKRLL 1130
Score = 99.8 bits (247), Expect = 1e-20
Identities = 99/320 (30%), Positives = 147/320 (45%), Gaps = 28/320 (8%)
Query: 207 WHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRR 266
W +EE + ++ R E R E + + + E +KR EEQ + ER + R
Sbjct: 669 WQDEEREKGEKDKGRGEME---RPGEGEKELAEKEEWKKRDGEEQEQK--EREQGHQKER 723
Query: 267 QELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERRERE---ERERLEAEEERRRL 323
+ +EE GE + E E REE++ E G E+ E E E E+E E ++E R
Sbjct: 724 NQEMEEGGEEEHGEGEEEEGDREEEEEK-EGEGKEEGEGEEVEGEREKEEGERKKEERAG 782
Query: 324 QAQAQAEERRRLEEDARLEERRRQEEEE------GRCAEELKRQEEEEAEGWEELEQQEA 377
+ + EE + E + E R +E+EE G E +EEEE EG E E+ E
Sbjct: 783 KEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEG 842
Query: 378 EVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLK 437
E + E EE GEG +G EE + GE EEEG E+ G+ E + E E + +
Sbjct: 843 E-EEEGEGEEEEGEG-KGEEEGEEGEGEEEG----EEGEGEGEEEEGEGEGEEEGEGEGE 896
Query: 438 PEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKRE-EGDTEPLLKQEG 496
E EE G E + E E + E++G G+ +G + G E + EG+ E ++EG
Sbjct: 897 EEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGE---EEEG 953
Query: 497 PVEAAQPPVERKEAAALEQG 516
E + E E E+G
Sbjct: 954 EWEGEE---EEGEGEGEEEG 970
Score = 90.1 bits (222), Expect = 1e-17
Identities = 92/315 (29%), Positives = 138/315 (43%), Gaps = 58/315 (18%)
Query: 230 ELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLE----------EEGEGQEP 279
E+E +++ AE ++ +EEQ ++A E + R+E E E EG+
Sbjct: 583 EVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAK 642
Query: 280 PL-EAERAPREEQQRSLEAPGWEDAERREREERERLE----------------------- 315
+ EAE P + E G AE + EERE+ E
Sbjct: 643 SVGEAEDGPEGRGDGTCEE-GSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEE 701
Query: 316 -----AEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEE--EEAEG 368
EE+ ++ + Q +ER + E+ EE EEEEG EE +++ E EE EG
Sbjct: 702 WKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEG 761
Query: 369 --------WEELEQQEAEVQGPPEALEETGEGRRGAEE--EDLGEEEEEG----QAHLED 414
EE E+++ E G E EE G+ G EE E GEE+EEG +E+
Sbjct: 762 EEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEE 821
Query: 415 WRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGA 474
+G+ E + E E+ E + EG+ E E G EE+ E E E++G G+ +G
Sbjct: 822 GKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGE--GEEEGEEGEGEGE 879
Query: 475 DRPGPEEKREEGDTE 489
+ G E EEG+ E
Sbjct: 880 EEEGEGEGEEEGEGE 894
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 114 bits (284), Expect = 7e-25
Identities = 108/425 (25%), Positives = 201/425 (47%), Gaps = 26/425 (6%)
Query: 114 EMEEKVAPVKPSRPKRHFSSAGTIESVNLDAIPLAIARLDNSAAKHKLAVKPKKQRVSKK 173
E++ K+ K P++ + L ++ A+L +++L + +Q+ K
Sbjct: 246 ELKRKLERAKLLLPQQQLQAEADHLGKELQSVS---AKLQAQVEENELWNRLNQQQEEKM 302
Query: 174 HRRLAQDPQHEQGGLESRPCL-DQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELE 232
R+ + + E+ E + +Q E + +E + EE+ RRQE+ E E
Sbjct: 303 WRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 362
Query: 233 AKCKRQKA---EAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPRE 289
K +RQ+ E EK R +E+ + E ++ E + E+ E +E E E+ +
Sbjct: 363 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 422
Query: 290 EQQRSLEAPGWEDAER-REREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQE 348
E+++ EA W E+ RE+EE+ R E E++ R + + +E+ R EE + +E ++
Sbjct: 423 EKRQEQEAKMWRQEEKIREQEEKIR-EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ 481
Query: 349 EEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEG 408
EE+ EE+ RQ+E+ E E++ +QE +V E + E E R +EE + +EE+
Sbjct: 482 EEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIR-EQEEKMWRQEEKI 540
Query: 409 QAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRS 468
+ E WR EE++ +QE++ E +R+ E+ +E E+ REQ+ +
Sbjct: 541 REQEEMWRE---------EEKMHEQEKIWEEEKRQEQEDKMWRQE-----EKIREQEEKV 586
Query: 469 GDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVD 528
+ R EEKR+E + E + KQE + + ++ +E EQ K+ E +
Sbjct: 587 WRQEEKIRE-QEEKRQEQE-EKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQE 644
Query: 529 ERQTM 533
+ + M
Sbjct: 645 QEEKM 649
Score = 105 bits (262), Expect = 3e-22
Identities = 94/362 (25%), Positives = 175/362 (48%), Gaps = 19/362 (5%)
Query: 176 RLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKC 235
R ++ HEQ + + Q ++ E+E EE+ R QE+ RE E K
Sbjct: 394 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM 453
Query: 236 KRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSL 295
RQ+ + E+ ++ E+ + + +W + + EE +E E E R+++++
Sbjct: 454 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVW 513
Query: 296 -EAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRC 354
+ + E + RE+ E++ +EE+ R Q + EE + E++ EE +RQE+E
Sbjct: 514 RQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQE---- 569
Query: 355 AEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLED 414
+++ RQEE+ E E++ +QE +++ E +E E + +EE + E+EE+ Q E
Sbjct: 570 -DKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQ-EEKMWKQEEKIREQEEKIQEQEEK 627
Query: 415 WRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNP----EAERRREQQGRSGD 470
R Q E + + EE ++QE E + + E+ +EQ + E+ REQ+ + +
Sbjct: 628 IREQ-EEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIRE 686
Query: 471 FQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRW-QEVDE 529
+ R E +E+ E + +QE + + ++ +E E+ R+ EE W QEV
Sbjct: 687 QEEKIREQEEMMQEQ--EEKMWEQEEKMCEQEEKMQEQE----EKMRRQEEKMWEQEVRL 740
Query: 530 RQ 531
RQ
Sbjct: 741 RQ 742
Score = 102 bits (253), Expect = 3e-21
Identities = 97/377 (25%), Positives = 179/377 (47%), Gaps = 34/377 (9%)
Query: 166 KKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQE 225
K + + +K + + E+ E +Q ++ W +EE E+ R +++
Sbjct: 392 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK 451
Query: 226 DYWRELEAKCKRQKAEAAEKRRLEEQRLQALER-----RLWEENRRQELLEEEGEGQEPP 280
WR+ E +++K EKR+ +E+ + E+ +W + + EE+ QE
Sbjct: 452 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEK 511
Query: 281 L---EAERAPREEQQRSLEAPGWEDAER-REREERERLEAEEERRRLQAQAQAEERRRLE 336
+ E + +EE+ R E W E+ RE+EE R EEE+ Q + EE+R+ +
Sbjct: 512 VWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR---EEEKMHEQEKIWEEEKRQEQ 568
Query: 337 EDA--RLEER-RRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGR 393
ED R EE+ R QEE+ R E+++ QEE+ E E++ +QE +++ E ++E
Sbjct: 569 EDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQE----- 623
Query: 394 RGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEE 453
+EE + E+EE+ + E+ + E + + EE++ +QE E +E E EE
Sbjct: 624 ---QEEKIREQEEKIREQ-EEMTQEQEEKMGEQEEKMCEQE----EKMQEQEETMWRQEE 675
Query: 454 QNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAAL 513
+ E E++ +Q Q EEK E + E + +QE ++ + + R+E
Sbjct: 676 KIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE-EKMCEQEEKMQEQEEKMRRQEEKMW 734
Query: 514 EQGRKVEELRWQEVDER 530
EQ E+R ++ +E+
Sbjct: 735 EQ-----EVRLRQQEEK 746
Score = 99.0 bits (245), Expect = 2e-20
Identities = 87/334 (26%), Positives = 163/334 (48%), Gaps = 47/334 (14%)
Query: 202 EDKPTWHEEEP----NPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQ--RLQA 255
++K W +EE + EE+R+ QE+ WR+ E K Q+ +K ++ EQ +++
Sbjct: 449 QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ-EEKIHEQEEIWRQKEKMHEQEEKIRK 507
Query: 256 LERRLWEENRRQELLEEEGEGQEPPL--------EAERAPREEQQRSLEAPGWEDAERRE 307
E ++W + + EE+ QE + E E REE++ + WE+ +R+E
Sbjct: 508 QEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQE 567
Query: 308 REERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAE 367
+E++ + E+ R Q E+ R EE R +E +RQE+EE ++ +QEE+ E
Sbjct: 568 QEDKMWRQEEKIRE------QEEKVWRQEEKIREQEEKRQEQEE-----KMWKQEEKIRE 616
Query: 368 GWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFE 427
E++++QE +++ E + E E + +EE +GE+EE+ E+ + E + E
Sbjct: 617 QEEKIQEQEEKIREQEEKIREQEEMTQ-EQEEKMGEQEEK-MCEQEEKMQEQEETMWRQE 674
Query: 428 ERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGD 487
E++ +QE+ E + + E+ + +EQ E+ EQ EEK E +
Sbjct: 675 EKIREQEKKIREQEEKIREQEEMMQEQE---EKMWEQ---------------EEKMCEQE 716
Query: 488 TEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEE 521
E + +QE + + + +E +Q K++E
Sbjct: 717 -EKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 94.4 bits (233), Expect = 6e-19
Identities = 85/358 (23%), Positives = 169/358 (47%), Gaps = 36/358 (10%)
Query: 202 EDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLW 261
E + +E + EE+ RRQE+ E E K + + + E+ ++ EQ E+R
Sbjct: 360 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE----EKRQE 415
Query: 262 EENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAER----------REREER 311
EE R++ +E E + E + +EE+ R E W E+ +R+E+
Sbjct: 416 EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQ 475
Query: 312 ERLEAEEER--------RRLQAQAQAEERRRLEEDA--RLEERRRQEEEEGRCAEE-LKR 360
E + +EE+ R+ + + EE+ R +E+ R EE+ R++EE+ R EE + R
Sbjct: 476 EEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWR 535
Query: 361 QEE---EEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRG 417
QEE E+ E W E E+ + + E + E + +EE + E+EE+ E R
Sbjct: 536 QEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIRE 595
Query: 418 QLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQ---NPEAERRREQQGRSGDFQGA 474
Q + E+ + +E+++ + ++ +E I E++ + E +EQ+ + G+ +
Sbjct: 596 QEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQE-- 653
Query: 475 DRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQG---RKVEELRWQEVDE 529
++ +E++ + E + +QE + + + +E EQ ++ EE W++ ++
Sbjct: 654 EKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK 711
Score = 93.6 bits (231), Expect = 1e-18
Identities = 72/249 (28%), Positives = 126/249 (50%), Gaps = 25/249 (10%)
Query: 202 EDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLW 261
E + E+E EE+ R QE+ WRE E +++K EKR+ +E ++ E ++
Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIR 580
Query: 262 EENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERR 321
E+ EE+ QE + + R+EQ+ + W+ E + RE+ E+++ +EE+
Sbjct: 581 EQ-------EEKVWRQEEKIREQEEKRQEQEEKM----WKQ-EEKIREQEEKIQEQEEKI 628
Query: 322 RLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGW---EELEQQEAE 378
R Q E+ R EE + +E + E+EE C +E K QE+EE W E++ +QE +
Sbjct: 629 R----EQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM-WRQEEKIREQEKK 683
Query: 379 VQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQE---R 435
++ E + E E + E+E+ E+EE E+ + E + EE++ +QE R
Sbjct: 684 IREQEEKIREQEEMMQ--EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLR 741
Query: 436 LKPEGQREH 444
+ E +EH
Sbjct: 742 QQEEKMQEH 750
Score = 72.0 bits (175), Expect = 3e-12
Identities = 75/302 (24%), Positives = 139/302 (46%), Gaps = 37/302 (12%)
Query: 232 EAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQ 291
+ + K + A+ EK +L E ++ + E R+ E + Q+ EA+ +E Q
Sbjct: 216 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 275
Query: 292 QRSLEAPGWEDAERREREERERLEAEEE----RRRLQAQAQAEERRRLEEDARLEERRRQ 347
S + A+ E E RL ++E R+ + Q E+ + EE R +E + +
Sbjct: 276 SVSAKL----QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 331
Query: 348 EEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEE 407
E+E E+++RQEE E E++ +QE E + E E R +E++ E+EE
Sbjct: 332 EQE-----EKMRRQEEMMWEKEEKMRRQE-------EMMWEKEEKMR--RQEEMMWEKEE 377
Query: 408 GQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGR 467
E+ + E + + EE++ +QE+++ + EE+ E E+ REQ+ R
Sbjct: 378 KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ------------EEKRQEEEKIREQEKR 425
Query: 468 SGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEV 527
Q A EEK E + E + +QE + + + +E E+ R+ +E W++
Sbjct: 426 QE--QEAKMWRQEEKIREQE-EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 482
Query: 528 DE 529
++
Sbjct: 483 EK 484
Score = 52.8 bits (125), Expect = 2e-06
Identities = 87/380 (22%), Positives = 147/380 (38%), Gaps = 78/380 (20%)
Query: 216 DSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGE 275
+ + + QE RELEA+ + +K L+ + E ++L+ +
Sbjct: 110 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 169
Query: 276 GQEPPLEAERAPREEQQRSLEAPGWEDAERRERE---ERERLEAEEERRRLQAQAQAEER 332
+ E E+A S A + A+R E ER+ L E R + + E+
Sbjct: 170 SWKFAGELEQA------LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKN 223
Query: 333 RRLEEDARLEERRRQEEEEGRCAEELKRQEE----------------------------- 363
+L+E +L E + E + +ELKR+ E
Sbjct: 224 AKLQEKLQLVESEKSEIQLN--VKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKL 281
Query: 364 ----EEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQL 419
EE E W L QQ+ E E + E + +EE + E+EE+ + E R Q
Sbjct: 282 QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ- 340
Query: 420 SELLNDFEERLEDQERL---KPEGQR---------------------EHSEEPGICEEQN 455
E++ + EE++ QE + K E R E E+ EE+
Sbjct: 341 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 400
Query: 456 PEAERRREQQGRSGDFQGADRPGPEEKREEGDT------EPLLKQEGPVEAAQPPVERKE 509
E E+ REQ+ + Q ++ +EKR+E + E + +QE + + + R+E
Sbjct: 401 HEQEKIREQEEKR---QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQE 457
Query: 510 AAALEQGRKVEELRWQEVDE 529
EQ + EE + QE +E
Sbjct: 458 EKIHEQEKIREEEKRQEQEE 477
Score = 42.4 bits (98), Expect = 0.003
Identities = 36/199 (18%), Positives = 83/199 (41%), Gaps = 46/199 (23%)
Query: 163 VKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERR 222
++ ++++V ++ ++ + + Q E ++ E+K E+E + EE+ R
Sbjct: 579 IREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKI--QEQEEKIREQEEKIR 636
Query: 223 RQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRR---------------- 266
QE+ +E E K Q+ + E +E+++Q E +W + +
Sbjct: 637 EQEEMTQEQEEKMGEQEEKMCE----QEEKMQEQEETMWRQEEKIREQEKKIREQEEKIR 692
Query: 267 --QELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQ 324
+E+++E+ E WE E+ +E + E EE+ RR +
Sbjct: 693 EQEEMMQEQEEKM----------------------WEQEEKMCEQEEKMQEQEEKMRRQE 730
Query: 325 AQAQAEERRRLEEDARLEE 343
+ +E R +++ +++E
Sbjct: 731 EKMWEQEVRLRQQEEKMQE 749
Score = 35.8 bits (81), Expect = 0.26
Identities = 33/173 (19%), Positives = 75/173 (43%), Gaps = 3/173 (1%)
Query: 1002 EPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPEAGR 1061
E +E +E R+ EE++ ++ ++ + E+ Q+EK + E R
Sbjct: 577 EKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIR 636
Query: 1062 KEKPMLQSRHSLDG---SKLTEKVETAQPLWITLALQKQKGFREQQATREERKQAREAKQ 1118
+++ M Q + G K+ E+ E Q T+ Q++K +++ RE+ ++ RE ++
Sbjct: 637 EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEE 696
Query: 1119 AEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPETAVSRLERREQLKK 1171
+ +E + + + + EEK E V ++ E++++
Sbjct: 697 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 35.0 bits (79), Expect = 0.44
Identities = 35/172 (20%), Positives = 73/172 (42%), Gaps = 13/172 (7%)
Query: 1007 DQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPEAGRKEKPM 1066
+QE R+ +E K ++++E+ E K Q+EK + E R+E+ M
Sbjct: 500 EQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWR------QEEKIREQEEMWREEEKM 553
Query: 1067 LQSRHSLDGSKLTEKVETAQPLWITLALQKQKGFREQQATREERKQAREA-----KQAEK 1121
+ + K E+ + + Q++K +R+++ RE+ ++ +E KQ EK
Sbjct: 554 HEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEK 613
Query: 1122 LSKENVSVSVQPGS--SSVSRAGSLHKSTALPEEKRPETAVSRLERREQLKK 1171
+ ++ + Q + + T EEK E E+ E++++
Sbjct: 614 IREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 665
Score = 33.1 bits (74), Expect = 1.7
Identities = 27/147 (18%), Positives = 67/147 (45%), Gaps = 4/147 (2%)
Query: 1022 EERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEK 1081
+E K ++++E+ E+K +QEK + + +E+ Q + ++ +
Sbjct: 435 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQ 494
Query: 1082 VETAQPLWITLALQKQKGFREQQATREERKQAREAKQAEKLSKENVSVSVQPGSSSVSRA 1141
E + Q++K +R+++ RE+ ++ RE Q EK+ ++ + Q
Sbjct: 495 KEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE--QEEKMWRQEEKIREQ--EEMWREE 550
Query: 1142 GSLHKSTALPEEKRPETAVSRLERREQ 1168
+H+ + EE++ + ++ R+E+
Sbjct: 551 EKMHEQEKIWEEEKRQEQEDKMWRQEE 577
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 114 bits (284), Expect = 7e-25
Identities = 104/341 (30%), Positives = 178/341 (52%), Gaps = 32/341 (9%)
Query: 218 EEERRRQEDYWRELEAKCKRQKA---EAAEKRRLEEQRLQALERRLWEEN---RRQELLE 271
EE+ RQE+ +E E K + Q+ E EK R +E++++ E +WE+ RRQE +
Sbjct: 299 EEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM 358
Query: 272 EEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREER----ERLEAEEERRRLQAQA 327
E E + LE +EE+ R LE E + RE+EE+ E++ +E+R+ +A+
Sbjct: 359 WEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 418
Query: 328 --QAEERRRLEEDARLEERR--RQEE---EEGRCAEELKRQEEEEAEGWEELEQQEAEVQ 380
Q E+ R EE R +E++ RQEE E+ + EE KRQE+EE EE +++ E+
Sbjct: 419 WRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIW 478
Query: 381 GPPEALEETGEGRRGAE-----EEDLGEEEEEGQAHLED-WRGQLSELLNDFEERLEDQE 434
E + E + R+ E EE + ++EE+ + E WR + E + + EE++ +QE
Sbjct: 479 RQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQE--EKIREQEEKIREQE 536
Query: 435 ---RLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPL 491
R + E +E E+ G EE+ E E+ R Q+ + + + R E+ RE+ E +
Sbjct: 537 EKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQ--EEKI 594
Query: 492 LKQEGPVEAAQPPVERKEAAALEQGRKV--EELRWQEVDER 530
+QE + + ++ +E EQ K+ +E + QE +E+
Sbjct: 595 WEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 635
Score = 101 bits (251), Expect = 5e-21
Identities = 102/369 (27%), Positives = 172/369 (46%), Gaps = 70/369 (18%)
Query: 202 EDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLW 261
E + E+E + EE+ RRQE+ E E K +RQ+ EK E++++ LE +W
Sbjct: 318 EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK----EEKMRRLEEMMW 373
Query: 262 EENRRQELLEEE-------GEGQEPPLEAERAPREEQQRSLEAPGWEDAER-REREER-- 311
E+ + LEE+ E +E E E+ +E+++ EA W E+ RE+EE+
Sbjct: 374 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 433
Query: 312 ----------ERLEAEEERRRLQAQAQAEERRRLEEDARLEER--------------RRQ 347
E++ +E+ R + + + EE R EE R +E R+Q
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQ 493
Query: 348 EEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEE------EDL 401
EE+ R E++ QEE+ E E++ +QE +++ E + E E R EE E +
Sbjct: 494 EEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKM 553
Query: 402 GEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERR 461
GE+EE+ Q E R Q E + + EE++ +Q+ E RE E+ EE+ E E
Sbjct: 554 GEQEEKMQEQ-EKMRRQ-EEKIREQEEKIREQK----EKIREQEEKIWEQEEKIREQEEM 607
Query: 462 REQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEE 521
++Q EEK E + E + +QE ++ + + R+E EQ E
Sbjct: 608 MQEQ--------------EEKMWEQE-EKMCEQEEKMQEQEEKMRRQEEKMWEQ-----E 647
Query: 522 LRWQEVDER 530
+R ++ +E+
Sbjct: 648 VRLRQQEEK 656
Score = 98.2 bits (243), Expect = 4e-20
Identities = 70/285 (24%), Positives = 138/285 (48%), Gaps = 16/285 (5%)
Query: 176 RLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKC 235
R ++ HEQ + + Q ++ E+E EE+ R QE+ RE E K
Sbjct: 380 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM 439
Query: 236 KRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSL 295
RQ+ + E+ ++ E+ + + +W + + EE +E E E+ ++E++
Sbjct: 440 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWR 499
Query: 296 EAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARL----EERRRQEEEE 351
+ D E + RE+ E++ +EE+ R Q + E+ ++ E + EE+ ++EE+
Sbjct: 500 QEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEK 559
Query: 352 GRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAH 411
+ E+++RQEE+ E E++ +Q+ +++ E + E E R E+E++ +E+EE
Sbjct: 560 MQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIR--EQEEMMQEQEEKMWE 617
Query: 412 LEDWRGQLSELLNDFEERLEDQE----------RLKPEGQREHSE 446
E+ + E + + EE++ QE R + E +EH E
Sbjct: 618 QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
Score = 93.6 bits (231), Expect = 1e-18
Identities = 79/346 (22%), Positives = 172/346 (49%), Gaps = 34/346 (9%)
Query: 215 LDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEG 274
L ++ + + +EL++ + +A+ E+ L + Q E ++W + + + EE+
Sbjct: 258 LPQQQLQAEADHLGKELQSVSAKLQAQV-EENELWNRLNQQQEEKMWRQEEKIQEWEEKI 316
Query: 275 EGQEPPL---EAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQA-QAE 330
+ QE + E + +EE+ R E WE E+ R+E E EE+ RRL+ + E
Sbjct: 317 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKE 376
Query: 331 ERRRLEEDARLEERRRQEEEEGRCAE----ELKRQEEEEAEGW---EELEQQEAEVQGPP 383
E+ R E+ E+ + +E+EE R E E ++++E+EA+ W E++ +QE +++
Sbjct: 377 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 436
Query: 384 EAL----------EETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQ 433
+ + E+ E + E+E++ +EE+ + E WR + E +++ E+ + +
Sbjct: 437 KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK--EKMHEQEKIRKQE 494
Query: 434 ERLKPEGQREHSEEPGICEEQNP---EAERRREQQGRSGDFQGADRPGPEEKREE----G 486
E++ + ++ H +E I E++ + E+ REQ+ + + + R E +E+ G
Sbjct: 495 EKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMG 554
Query: 487 DTEPLLKQEGPVEAAQPPVERKEAAALEQGRKV---EELRWQEVDE 529
+ E ++++ + + + +E EQ K+ EE W++ ++
Sbjct: 555 EQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEK 600
Score = 90.1 bits (222), Expect = 1e-17
Identities = 71/253 (28%), Positives = 132/253 (52%), Gaps = 30/253 (11%)
Query: 202 EDKPTWHEEEP----NPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQ-RLQAL 256
++K W +EE + EE+R+ QE+ WR+ E K + Q+ +K ++ EQ +++
Sbjct: 435 QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ-EEKIREQEEIWRQKEKMHEQEKIRKQ 493
Query: 257 ERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEA 316
E ++W + + EE+ QE E+ R+E++ + E + RE+ E++
Sbjct: 494 EEKVWRQEEKMHDQEEKIREQE-----EKMWRQEEKI-------REQEEKIREQEEKIRE 541
Query: 317 EEERRRLQAQAQAEERRRLEEDARL---EERRRQEEEEGRCAEELKRQEEEEAEGWEELE 373
+EE + Q + E+ +++E ++ EE+ R++EE+ R +E R++EE+ WE
Sbjct: 542 QEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKI--WE--- 596
Query: 374 QQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQ 433
QE +++ E ++E E + +EE + E+EE+ Q E R Q E + + E RL Q
Sbjct: 597 -QEEKIREQEEMMQEQ-EEKMWEQEEKMCEQEEKMQEQEEKMRRQ-EEKMWEQEVRLRQQ 653
Query: 434 ERLKPEGQREHSE 446
E K + +EH E
Sbjct: 654 EE-KMQEHQEHLE 665
Score = 75.1 bits (183), Expect = 4e-13
Identities = 58/222 (26%), Positives = 110/222 (49%), Gaps = 11/222 (4%)
Query: 158 KHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDS 217
+ K+ + K+Q + R+ + + E+ + +Q +++ W +EE
Sbjct: 449 QEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQE 508
Query: 218 EEERRRQEDYWRELEAKCKRQKA---EAAEKRRLEEQRLQALERRLWEENRRQELLEEEG 274
E+ R ++E WR+ E K + Q+ E EK R +E+ +Q E ++ E+ + + E+
Sbjct: 509 EKIREQEEKMWRQ-EEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMR 567
Query: 275 EGQEPPLEAERAPREEQQ--RSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEER 332
+E E E RE+++ R E WE E + RE+ E ++ +EE+ Q + E+
Sbjct: 568 RQEEKIREQEEKIREQKEKIREQEEKIWEQ-EEKIREQEEMMQEQEEKMWEQEEKMCEQE 626
Query: 333 RRLEEDARLEERRRQEEEEGRCAE-ELKRQEEEEAEGWEELE 373
+++E EE+ R++EE+ E L++QEE+ E E LE
Sbjct: 627 EKMQEQ---EEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 66.2 bits (160), Expect = 2e-10
Identities = 76/309 (24%), Positives = 143/309 (46%), Gaps = 32/309 (10%)
Query: 232 EAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQ 291
+ + K + A+ EK +L E ++ + E R+ E + Q+ EA+ +E Q
Sbjct: 216 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 275
Query: 292 QRSLEAPGWEDAERREREERERLEAEEE----RRRLQAQAQAEERRRLEEDARLEERRRQ 347
S + A+ E E RL ++E R+ + Q E+ + EE R +E + +
Sbjct: 276 SVSAKL----QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 331
Query: 348 EEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEE 407
E+E E+++RQEE E E++ +QE E + E E R EE + E+EE
Sbjct: 332 EQE-----EKMRRQEEMMWEKEEKMRRQE-------EMMWEKEEKMRRLEE--MMWEKEE 377
Query: 408 GQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSE------EPGICEEQNPEAERR 461
LE+ + E + + EE+ +++E+++ + +R+ E E I E++ E+
Sbjct: 378 KIRELEE-KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 436
Query: 462 REQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAA-ALEQGRKVE 520
++ + ++ EEKR+E E + +QE + + +KE E+ RK E
Sbjct: 437 KKMWRQEEKIHEQEKIREEEKRQE--QEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQE 494
Query: 521 ELRWQEVDE 529
E W++ ++
Sbjct: 495 EKVWRQEEK 503
Score = 58.2 bits (139), Expect = 5e-08
Identities = 87/366 (23%), Positives = 147/366 (40%), Gaps = 64/366 (17%)
Query: 216 DSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGE 275
+ + + QE RELEA+ + +K L+ + E ++L+ +
Sbjct: 110 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 169
Query: 276 GQEPPLEAERAPREEQQRSLEAPGWEDAERRERE---ERERLEAEEERRRLQAQAQAEER 332
+ E E+A S A + A+R E ER+ L E R + + E+
Sbjct: 170 SWKFAGELEQA------LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKN 223
Query: 333 RRLEEDARLEERRRQEEEEGRCAEELKRQEE----------------------------- 363
+L+E +L E + E + +ELKR+ E
Sbjct: 224 AKLQEKLQLVESEKSEIQLN--VKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKL 281
Query: 364 ----EEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQL 419
EE E W L QQ+ E E + E + +EE + E+EE+ + E R Q
Sbjct: 282 QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ- 340
Query: 420 SELLNDFEERLEDQERL---KPEGQR-------EHSEEPGICEEQNPEAERRREQQGRSG 469
E++ + EE++ QE + K E R E E+ EE+ E E+ REQ+ +
Sbjct: 341 EEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKR- 399
Query: 470 DFQGADRPGPEEKREEGDT------EPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELR 523
Q ++ +EKR+E + E + +QE + + + R+E EQ + EE +
Sbjct: 400 --QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK 457
Query: 524 WQEVDE 529
QE +E
Sbjct: 458 RQEQEE 463
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 113 bits (283), Expect = 1e-24
Identities = 115/415 (27%), Positives = 197/415 (47%), Gaps = 59/415 (14%)
Query: 166 KKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQE 225
++Q++ ++ + +HEQ E R +Q E++ W + E E+ERR+Q+
Sbjct: 421 REQQLRREQEEERHEQKHEQERREQRLKREQ-----EERRDWLKREEETERHEQERRKQQ 475
Query: 226 ----------DYWRELEAKCKRQKAEAAE---KRRLEEQRLQALERRLWEENRRQELLEE 272
+ W +LE + +R++ E E +R EE+R Q L+R+ EE +Q L E
Sbjct: 476 LKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE 535
Query: 273 EGEGQEPPLEAERAPREEQQRSLEAPGWEDAERRERE-ERER-LEAEEERR--------- 321
+ +E E+ + E+++ LE E +RE+E R++ L+ EEERR
Sbjct: 536 QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE 595
Query: 322 -RLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEEL--EQQEAE 378
RL+ + + EE RLE++ R E+R ++EE E ++L + EE+E ++L EQQE
Sbjct: 596 ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERR 655
Query: 379 VQG-PPEALEETGEGRRGAE------EEDLGEEEEEG-----QAHLEDWRGQLSELLNDF 426
Q E EE E R E E++L EEE+E ++ + W+ QL +
Sbjct: 656 EQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR 715
Query: 427 EERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEG 486
+ ++ + R K EGQR E+ E RRRE + + + + A R EE++
Sbjct: 716 QSKVYSRPR-KQEGQRRRQEQ--------EEKRRRRESELQWQEEERAHRQQQEEEQRRD 766
Query: 487 DTEPLLKQEGPVE-----AAQPPV-ERKEAAALEQGRKVEELRWQEVDERQTMPR 535
T +E +A+PP+ E++E + R+ E R+ +E + R
Sbjct: 767 FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR 821
Score = 111 bits (277), Expect = 5e-24
Identities = 120/430 (27%), Positives = 188/430 (43%), Gaps = 44/430 (10%)
Query: 116 EEKVAPVKPSRPKRHFSSAGTIESVNLDAIPLAIARLDNSAAKHKLAVKPKKQRVSKKHR 175
EEK+ +P R + + L+ L R + + +L + + +R ++ R
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQLRK--LERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314
Query: 176 RLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKC 235
R Q+ + EQ E + E L E+E RR++ RE E +
Sbjct: 315 REQQEERREQQ---------------ERREQQEERREQQLRREQEERREQQLRREQEEER 359
Query: 236 KRQ--KAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQR 293
+ Q + E E+RR ++ R + RR + R Q+L E+ +E L E+ R EQQ
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419
Query: 294 SLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGR 353
E + R + EER + E+ERR + + + EERR + R EE R E+E R
Sbjct: 420 RRE----QQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK--REEETERHEQE--R 471
Query: 354 CAEELKR-QEEEEAEGW------EELEQQEAEVQGPPEALEETGEGR--RGAEEEDLGEE 404
++LKR QEEE E W E EQQE Q EE E R R EEE L +
Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR 531
Query: 405 EEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGIC---EEQNPEAERR 461
Q + + +LL EE+ +QER + +RE E EE+ + +
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLK 591
Query: 462 REQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEE 521
REQ+ R Q R E +E E LK+E P E + + + E ++ R+ ++
Sbjct: 592 REQEERLE--QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEE---QEERRQQQ 646
Query: 522 LRWQEVDERQ 531
LR ++ + R+
Sbjct: 647 LRREQQERRE 656
Score = 110 bits (276), Expect = 6e-24
Identities = 111/414 (26%), Positives = 184/414 (44%), Gaps = 52/414 (12%)
Query: 164 KPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRR 223
+ +++R +K ++L Q + G + + ++ +EE L E E+RR
Sbjct: 953 RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRR 1012
Query: 224 QEDYWRELEAKCKRQKAEAA------EKRRLEEQRLQALERRLWEENRRQELLEEEGEGQ 277
++++ R+ K + Q+ E EKRRL+E+ Q E ++ Q L EE +
Sbjct: 1013 RQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRR 1072
Query: 278 EPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAE------EERRRLQAQAQAEE 331
LE + EE Q+ E E+ E+R R+ERER E EE + L+ + +
Sbjct: 1073 RQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR 1132
Query: 332 RRRLEEDARLEERRRQEEE-------EGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPE 384
R+ LE R EE +QEEE E R +EL+RQ EE EEL+Q+E ++ +
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE----EELQQEEEQLLREEQ 1188
Query: 385 ALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQL-------------------SELLND 425
R+ EEE+L ++ + + ED R L N+
Sbjct: 1189 EKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENE 1248
Query: 426 FEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKRE- 484
+LED + + Q++ G +E++ E ERRR QQ R F ++ EE++E
Sbjct: 1249 QFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQ-RDRHFPEEEQLEREEQKEA 1307
Query: 485 ------EGDTEPLLKQEGPVEAAQPPVERK--EAAALEQGRKVEELRWQEVDER 530
+ + LL++E + + +RK E L Q R+ + LR QE D +
Sbjct: 1308 KRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRK 1361
Score = 108 bits (271), Expect = 2e-23
Identities = 111/405 (27%), Positives = 187/405 (46%), Gaps = 53/405 (13%)
Query: 166 KKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEER---R 222
++Q S K + P EQ L R L+ E+K E + + EEE R
Sbjct: 190 EEQLQSCKGHETEEFPDEEQ--LRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWR 247
Query: 223 RQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLE 282
++E R+ E K + ++ + + + EE++L+ LER +E RR E QE +
Sbjct: 248 KRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLER---QELRR--------ERQEEEQQ 296
Query: 283 AERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEER-----RRLEE 337
+R RE+Q R + + + RE++ER E +EERR Q + + EER RR +E
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356
Query: 338 DARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQ--------GPPEALEET 389
+ R E++ R+E+EE R ++L+R+++ E EQQ Q + L
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 416
Query: 390 GEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLE-----------DQERLKP 438
+ RR + EEE Q H ++ R Q L + EER + +QER K
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQ--RLKREQEERRDWLKREEETERHEQERRKQ 474
Query: 439 EGQREHSEEP-----GICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEG-----DT 488
+ +R+ EE + EE+ E + RREQQ R + ++ ++ EE +
Sbjct: 475 QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRS 534
Query: 489 EPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQTM 533
E L++E E + ++R+E LEQ R+ + L+ ++ + R +
Sbjct: 535 EQQLRRE-QEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578
Score = 108 bits (271), Expect = 2e-23
Identities = 114/387 (29%), Positives = 186/387 (48%), Gaps = 44/387 (11%)
Query: 164 KPKKQRVSKKHR-RLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERR 222
+ ++QR +K R +L ++ + + L ++P L + +++ EEE E E+R
Sbjct: 864 RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR--KEQQLLQEEEEELQREEREKR 921
Query: 223 RQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPP-- 280
R+++ R+ + + Q+ E R E+R + R + ++++ + EE+ G+EP
Sbjct: 922 RRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR 981
Query: 281 --LEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEER--RRLE 336
E E+ REE++ E E R ERE+R R E E + R+ Q EE+ R
Sbjct: 982 RRQEREKKYREEEELQQEE---EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREER 1038
Query: 337 EDARLEERRRQ--EEEEGRCAEELKRQEEEEAEGWEELEQQ---EAEVQGPPE-ALEETG 390
E RL+ER RQ EEEE + EE EE E +ELE+Q E E+Q E L E
Sbjct: 1039 EKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEP 1098
Query: 391 EGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGI 450
E RR E E EEEE Q E +LL R E ++R + E +R++ EE +
Sbjct: 1099 EKRRRQERERQCREEEELQQEEE-------QLL-----REEREKRRRQELERQYREEEEV 1146
Query: 451 CEEQ----NPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVE 506
+E+ E E+RR Q+ +R EE+ + + E LL++E E + E
Sbjct: 1147 QQEEEQLLREEPEKRRRQE--------LERQYREEEELQQEEEQLLREE--QEKRRQERE 1196
Query: 507 RKEAAALEQGRKVEELRWQEVDERQTM 533
R+ E R+ + R+++ D+R +
Sbjct: 1197 RQYREEEELQRQKRKQRYRDEDQRSDL 1223
Score = 103 bits (256), Expect = 1e-21
Identities = 99/381 (25%), Positives = 173/381 (45%), Gaps = 51/381 (13%)
Query: 167 KQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQED 226
++R + R+L ++P + + R ++ GE++ E+ L+ + +RR E+
Sbjct: 119 QRRFEPRDRQLEEEPGQRRR--QKRQEQERELAEGEEQ----SEKQERLEQRDRQRRDEE 172
Query: 227 YWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEEN------RRQELLEEEGEGQEPP 280
WR+ RQ+ + E+RR EE++LQ+ + EE RR+ELLE +G+E
Sbjct: 173 LWRQ------RQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEK 226
Query: 281 LEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDAR 340
+ R ++ + E W E R+E E+L+ EE +R+ + Q + E+ R+LE
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286
Query: 341 LEERRRQEEEEGRCAEE--LKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEE 398
ER+ +E+++ R E L+R++EEE EQQE E R E
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERR-----EQQE--------------ERREQQER 327
Query: 399 EDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEA 458
+ EE E Q E + +L + EE +Q+ L+ E + E E+ + E
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQ-LRREQEEERREQ-----QLRREQ 381
Query: 459 ERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQ----PPVERKEAAALE 514
+ RREQQ R Q R + ++ E L++E + Q E + E
Sbjct: 382 QLRREQQLRRE--QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439
Query: 515 QGRKVEELRWQEVDERQTMPR 535
Q R+ + L+ ++ + R + R
Sbjct: 440 QERREQRLKREQEERRDWLKR 460
Score = 102 bits (254), Expect = 2e-21
Identities = 116/396 (29%), Positives = 186/396 (46%), Gaps = 47/396 (11%)
Query: 167 KQRVSKKHRRLAQDPQHEQGGLESRPCLD--QNGHPGEDKPTWHEEEPNPLDSEEERRRQ 224
++ ++ RR ++ + E LE L + +++ +E+ S+E+RR Q
Sbjct: 813 EEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ 872
Query: 225 EDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAE 284
+ W +LE + KR++ K L+EQ L+ ++ L EE +EL EE E + E E
Sbjct: 873 KWRW-QLEEERKRRRHTLYAKPALQEQ-LRKEQQLLQEE--EEELQREEREKRRRQ-EQE 927
Query: 285 RAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEER 344
R REE+Q E E R ERE+R R E E + R+ + Q EE+ EE E+R
Sbjct: 928 RQYREEEQLQQEE---EQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEP---EKR 981
Query: 345 RRQEEEEGRCAEELKRQEEEE----------AEGWEELEQQEAEVQGPPE-ALEETGEGR 393
RRQE E+ EE +QEEE+ + WE +++ E+Q E L E E R
Sbjct: 982 RRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041
Query: 394 RGAEEEDLGEEEEEGQAHLEDWRGQ---------------LSELLNDFEERL---EDQER 435
R E E EEEE Q E G+ E L EE+L E ++R
Sbjct: 1042 RLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKR 1101
Query: 436 LKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQE 495
+ E +R+ EE + +E+ RE++ R Q +R EE+ + + E LL++E
Sbjct: 1102 RRQERERQCREEEELQQEEEQLLREEREKRRR----QELERQYREEEEVQQEEEQLLREE 1157
Query: 496 GPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQ 531
P + + +ER+ E ++ E+L +E ++R+
Sbjct: 1158 -PEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192
Score = 100 bits (248), Expect = 1e-20
Identities = 112/415 (26%), Positives = 185/415 (44%), Gaps = 54/415 (13%)
Query: 158 KHKLAVKPKKQRVSKKHRRLAQDPQHE--QGGLESRPCLDQNGHPGEDKPTWHEEEPNPL 215
+H L KP Q +K ++L Q+ + E + E R +Q E++ EEE
Sbjct: 886 RHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLR 945
Query: 216 DSEEER-RRQEDYW----RELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELL 270
+ E+R R++ + ++L+ K ++ E EKRR +E+ + E ++ Q L
Sbjct: 946 EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLR 1005
Query: 271 EEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEE----------- 319
EE + + E + ++E Q+ E E+ E+R +ERER EEE
Sbjct: 1006 EEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065
Query: 320 -------RRRLQAQAQAEERRRLEEDARLE---ERRRQEEEEGRCAEELKRQEEEE---A 366
R+ L+ Q + EE + EE+ L E+RR++E E +C EE + Q+EEE
Sbjct: 1066 EERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLR 1125
Query: 367 EGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLE-DWRGQLSELLND 425
E E+ +QE E Q E EE + EEE L EE E + E + + + E L
Sbjct: 1126 EEREKRRRQELERQYREE--EEVQQ-----EEEQLLREEPEKRRRQELERQYREEEELQQ 1178
Query: 426 FEERL--EDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPE--- 480
EE+L E+QE+ + E +R++ EE E Q + ++R + + D + P E
Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEE---ELQRQKRKQRYRDEDQRSDLKWQWEPEKENAV 1235
Query: 481 -------EKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVD 528
+ RE L + +Q ++ E+ R+ E RWQ+ D
Sbjct: 1236 RDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRD 1290
Score = 97.4 bits (241), Expect = 7e-20
Identities = 98/326 (30%), Positives = 160/326 (49%), Gaps = 29/326 (8%)
Query: 215 LDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQ-ELLEEE 273
L E++ RR++ RE E + QK E ++RR + + + ERR W + + E E+E
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHE--QERREQRLKREQEERRDWLKREEETERHEQE 470
Query: 274 GEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERR 333
Q+ + E RE + E E ERRE ++L E+E RR Q + EE
Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERRE----QQLRREQEERREQRLKRQEEEE 526
Query: 334 RLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGR 393
RL++ R E++ R+E+EE R E+L ++EEE + LEQ+ E + L+ E R
Sbjct: 527 RLQQRLRSEQQLRREQEERR--EQLLKREEE-----KRLEQERRE-----QRLKREQEER 574
Query: 394 RGAEEEDLGEEEEEGQAHLEDWRGQLSE--LLNDFEERLEDQERLKPEGQREHSEEPGIC 451
R ++ L EEE Q L+ + + E L + ERLE +ER + +RE EE
Sbjct: 575 R---DQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQ 631
Query: 452 E-EQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEA 510
+ ++ E E RR+QQ R + ++ E+ EE + L ++ Q E ++
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691
Query: 511 AALEQGR-KVEELRWQ---EVDERQT 532
A E+ + ++ + +WQ E D RQ+
Sbjct: 692 QARERIKSRIPKWQWQLESEADARQS 717
Score = 97.4 bits (241), Expect = 7e-20
Identities = 111/422 (26%), Positives = 192/422 (45%), Gaps = 66/422 (15%)
Query: 167 KQRVSKKHRRLAQDPQHEQGGLESRPCL----------DQNGHPGEDKPTWHEEEPNPLD 216
K R+ K +L + Q + SRP ++ E + W EEE
Sbjct: 698 KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQ 757
Query: 217 SEEERRRQEDYWR-ELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGE 275
+EE +R++ W+ + E K +R + + + L EQR + L R + R Q L EE E
Sbjct: 758 QQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQL-RAEERQQREQRFLPEEEE 816
Query: 276 GQEPPLEAERAPREEQQRSLEAPGWEDAERRER-----EERERLEAEEERRRLQAQAQAE 330
++ +R RE++ + LE E +RRER EE + L+ ++ERRR Q Q + +
Sbjct: 817 KEQR--RRQRREREKELQFLEEE--EQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ 872
Query: 331 ERR-RLEEDAR-----------LEERRR-------QEEEEGRCAEELKRQEEEEAEGWEE 371
+ R +LEE+ + L+E+ R +EEEE + E KR+ +E+ + E
Sbjct: 873 KWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYRE 932
Query: 372 LEQQEAEVQGPPEALEETGEGRR---------------GAEEEDLGEEEEEGQAHLEDWR 416
EQ + E + + L E E RR EE+ LGEE E+ + + +
Sbjct: 933 EEQLQQEEE---QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK 989
Query: 417 GQLSELLNDFEERL---EDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQG 473
+ E L EE+L E ++R + E +R++ ++ + +E+ RE++ Q
Sbjct: 990 YREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR----RLQE 1045
Query: 474 ADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQTM 533
+R EE+ + + E LL +E Q +ER+ E ++ E+L +E ++R+
Sbjct: 1046 RERQYREEEELQQEEEQLLGEERETRRRQ-ELERQYRKEEELQQEEEQLLREEPEKRRRQ 1104
Query: 534 PR 535
R
Sbjct: 1105 ER 1106
Score = 96.7 bits (239), Expect = 1e-19
Identities = 98/399 (24%), Positives = 181/399 (45%), Gaps = 25/399 (6%)
Query: 153 DNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEP 212
+ S + +L + +++R + R+ + + E+ E GH E+ P +
Sbjct: 153 EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212
Query: 213 NPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEEN--RRQELL 270
L + R+E + E + + + E ++ R E L+ E +L EE R++EL
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272
Query: 271 EEEGEGQE---PPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQA 327
EEE + ++ L ER E+QQ+ L + + R ++E ER E +EERR Q +
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLR----REQQLRRKQEEERREQQEERREQQERR 328
Query: 328 QAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALE 387
+ +E RR E+ R E+ R+E++ R EE +R+++ E EE +Q+ + +
Sbjct: 329 EQQEERR-EQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387
Query: 388 ETGEGRRGAEEEDLGEEEE---EGQAHLEDWRGQLSELLNDFEERLEDQ--------ERL 436
+ ++ E+ L E++ E Q E + +L + EE +Q +RL
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447
Query: 437 KPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADR---PGPEEKREEGD-TEPLL 492
K E + E + E ERR++Q R + + +R EE+RE+ + E L
Sbjct: 448 KREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL 507
Query: 493 KQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQ 531
++E Q ++E L+Q + E+ +E +ER+
Sbjct: 508 RREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERR 546
Score = 93.2 bits (230), Expect = 1e-18
Identities = 90/335 (26%), Positives = 152/335 (45%), Gaps = 41/335 (12%)
Query: 230 ELEAKCKRQKAEAAEKRRLEEQR-LQALERRLWEE------NRRQELLEEEGEGQEPPLE 282
E A+C +++ ++R+ E+QR + +R+L EE +RQE E EG+E +
Sbjct: 98 EKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEK 157
Query: 283 AERAPREEQQRSLEAPGWEDAERREREERERLEAEEER---------------RRLQAQA 327
ER + ++QR E W +R+E +ERE AEEE+ +L+ +
Sbjct: 158 QERLEQRDRQRRDEEL-WR--QRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 328 QAEERRRLEEDARLEERRRQ-------EEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQ 380
E RR+ E+ + + R RQ EE+E R E + R+EEE+ + E Q+E
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE---- 270
Query: 381 GPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEG 440
L+E E R E ++L E +E + + R + EER E QE + +
Sbjct: 271 -----LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325
Query: 441 QREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEA 500
+R +E ++ E E RREQQ R + ++EE E L++E +
Sbjct: 326 ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR 385
Query: 501 AQPPVERKEAAALEQGRKVEELRWQEVDERQTMPR 535
Q ++ +Q R+ ++LR ++ R+ R
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 420
Score = 92.0 bits (227), Expect = 3e-18
Identities = 100/347 (28%), Positives = 164/347 (47%), Gaps = 40/347 (11%)
Query: 216 DSEEERRRQEDYWRELEAKCKRQK-------------AEAAEKRRLEEQRLQALERRLWE 262
+ EEERR QE E E +R K A+A + + R Q +RR E
Sbjct: 675 EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE 734
Query: 263 ENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEA-----E 317
+ ++ E E + QE A R +EE+QR W+ E+ ER R+RL A E
Sbjct: 735 QEEKRRRRESELQWQEEE-RAHRQQQEEEQRRDFTWQWQAEEKSER-GRQRLSARPPLRE 792
Query: 318 EERRRLQA-QAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQE 376
+ R+L+A + Q E+R L E+ E+RRRQ E + + L +EEE+ + E +Q +
Sbjct: 793 QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFL--EEEEQLQRRERAQQLQ 850
Query: 377 AEVQGPPEALE--ETGEGRRGAEEEDLGEEEEEGQAH-------LEDWRGQLSELLNDFE 427
E G E E + E RR + EEE + + H L++ + +LL + E
Sbjct: 851 EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE 910
Query: 428 ERLEDQERLK---PEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKRE 484
E L+ +ER K E +R++ EE + +E+ RE++ R Q +R ++K+
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR----QERERQYRKDKKL 966
Query: 485 EGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQ 531
+ E LL +E P + + E+K E ++ E+L +E ++R+
Sbjct: 967 QQKEEQLLGEE-PEKRRRQEREKKYREEEELQQEEEQLLREEREKRR 1012
Score = 91.7 bits (226), Expect = 4e-18
Identities = 100/389 (25%), Positives = 184/389 (47%), Gaps = 35/389 (8%)
Query: 166 KKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQE 225
++Q +K + Q + ++ + R D+ E + + E + + E++ RRQE
Sbjct: 1384 RRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQE 1443
Query: 226 DYWRELEAKCKRQKAEAAEKRRLEEQRLQALE-RRLWEENRRQELLEEEGEGQEPPLEAE 284
+ LE + ++ + E K R EEQ LQ E ++L + R ++ LEEE + + E +
Sbjct: 1444 RERKFLEEE-QQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ--ERD 1500
Query: 285 RAPREEQQRSLEAPG--WEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLE 342
R RE++ RS E E+ ++ R++R+R +EE++ + + + R+ + R E
Sbjct: 1501 RKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE 1560
Query: 343 ERRRQEEEEGRCA----------EELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEG 392
E+ RQE EE + + EE K + +E+ + E EQQ +G + +E
Sbjct: 1561 EQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE--RD 1618
Query: 393 RRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICE 452
R+ E+E L +E EE Q H ++ + E R E +++L+ + R+ EE + +
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQL-RRQEREQQLRHDRDRKFREEEQLLQ 1677
Query: 453 EQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERK--EA 510
E + RR+E+ + + + R E++ + + L +QE +ERK E
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQE---------LERKFREE 1728
Query: 511 AALEQGRKVEELRWQE-----VDERQTMP 534
L Q + E+LR QE ++E Q P
Sbjct: 1729 EQLRQETEQEQLRRQERYRKILEEEQLRP 1757
Score = 91.3 bits (225), Expect = 5e-18
Identities = 115/385 (29%), Positives = 179/385 (46%), Gaps = 46/385 (11%)
Query: 164 KPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRR 223
K ++Q + +++R + Q E+ L +Q E + + EEE ++R R
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLRE----EQEKRRQERERQYREEEELQRQKRKQRYR 1215
Query: 224 QEDYWRELEAKCKRQKAEAAE------KRRLEEQRLQALERRLWEENRRQELLEEEGEGQ 277
ED +L+ + + +K A K R EQ Q + +L + +Q+L GE Q
Sbjct: 1216 DEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQ 1275
Query: 278 EPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAE-EERRRLQAQAQAEERRRLE 336
E E ER R QQR P E ER E++E +R + + +E ++L + + E+RRR E
Sbjct: 1276 ERDREQER--RRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQE 1333
Query: 337 EDA--RLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRR 394
D R EE+ QE EE + L+RQE + EEL QE QG + LEE RR
Sbjct: 1334 TDRKFREEEQLLQEREE----QPLRRQERDRKFREEELRHQE---QG-RKFLEEEQRLRR 1385
Query: 395 GAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQ 454
E +EE+ Q ++ QL + D + R E+Q+ + E R+ EE E+Q
Sbjct: 1386 QERERKFLKEEQ--QLRCQEREQQLRQ-DRDRKFREEEQQLSRQERDRKFREE----EQQ 1438
Query: 455 NPEAERRR-----EQQGRSGDFQGADRPGPEEKR--EEGDTEPLLKQEGPVEAAQPPVER 507
ER R EQQ R Q R EE++ +E + + L +QE + + E
Sbjct: 1439 VRRQERERKFLEEEQQLR----QERHRKFREEEQLLQEREEQQLHRQERDRKFLE---EE 1491
Query: 508 KEAAALEQGRKV--EELRWQEVDER 530
++ E+ RK +ELR QE + +
Sbjct: 1492 QQLRRQERDRKFREQELRSQEPERK 1516
Score = 91.3 bits (225), Expect = 5e-18
Identities = 100/391 (25%), Positives = 181/391 (46%), Gaps = 35/391 (8%)
Query: 167 KQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQED 226
+ R ++ +L Q+ + +Q + R D+ E K E+E ++ E++ RRQE
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSRQER---DRKFRLEEQKVRRQEQERKFMEDEQQLRRQEG 1609
Query: 227 YWRELEAKCKRQKAEAAEKRRLEEQRLQALE-RRLWEENRRQELLEEEGE----GQEPPL 281
++ + E K R +EQ LQ E ++L + R ++ LEEE + +E L
Sbjct: 1610 Q--------QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661
Query: 282 EAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARL 341
+R + ++ L G E RR+ +R+ E E++ RR Q ER+ L+E+ +L
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRR-----QERERKFLQEEQQL 1716
Query: 342 -----EERRRQEEE--EGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRR 394
E + R+EE+ + E+L+RQE + LE+++ + + L R+
Sbjct: 1717 RRQELERKFREEEQLRQETEQEQLRRQERYR----KILEEEQLRPEREEQQLRRQERDRK 1772
Query: 395 GAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQER-LKPEGQREHSEEPGICEE 453
EEE L +E EE Q ++ + E +ER E Q R + +G+ EE EE
Sbjct: 1773 FREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEE 1832
Query: 454 QNPEAERRREQQGRSGD-FQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAA 512
Q + R++Q R+ + F ++ EE+ + E +QE + + + R++
Sbjct: 1833 QEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEE 1892
Query: 513 LEQGRKVEELRWQEVDERQTMPRPYTFQVSS 543
++ R+V E++ QE + P T Q +S
Sbjct: 1893 -QRHRQVGEIKSQEGKGHGRLLEPGTHQFAS 1922
Score = 90.9 bits (224), Expect = 7e-18
Identities = 99/324 (30%), Positives = 153/324 (47%), Gaps = 54/324 (16%)
Query: 236 KRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSL 295
+ ++A K L + R Q ++R +E RQ LEEE P + R R+EQ+R L
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQ--LEEE------PGQRRRQKRQEQEREL 148
Query: 296 EAPGWEDAERRER-EERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRC 354
A G E +E++ER E+R+R +EE R +R+ +E E RR EEE+ +
Sbjct: 149 -AEGEEQSEKQERLEQRDRQRRDEELWR--------QRQEWQE----REERRAEEEQLQS 195
Query: 355 A-----------EELKRQE--EEEAEGWEELEQQEAEVQGPPEALEETGEGRR-----GA 396
E+L+R+E E +G EE +QQ E Q EE E R+
Sbjct: 196 CKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRK 255
Query: 397 EEEDLGEEEEEGQAHLEDWRGQL-----SELLNDFEERLEDQERLKPEGQREHSEEPGIC 451
EEE L EEE + Q L++ QL EL + +E + Q+RL+ E Q +E
Sbjct: 256 EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE---- 311
Query: 452 EEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAA 511
EE+ + E RREQQ R + Q R + +E E L++E E + + R++
Sbjct: 312 EERREQQEERREQQERR-EQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ-- 368
Query: 512 ALEQGRKVEELRWQEVDERQTMPR 535
E+ R+ ++LR ++ R+ R
Sbjct: 369 --EEERREQQLRREQQLRREQQLR 390
Score = 88.6 bits (218), Expect = 3e-17
Identities = 107/397 (26%), Positives = 179/397 (45%), Gaps = 45/397 (11%)
Query: 166 KKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDS-------- 217
++ R S++ ++L ++ + E+ R + + E++ E E PL
Sbjct: 1309 RRDRKSQEEKQLLREEREEK-----RRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR 1363
Query: 218 EEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQ 277
EEE R QE + LE + + ++ E K EEQ+L+ ER R EE E Q
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREE-EQQ 1422
Query: 278 EPPLEAERAPREEQQ---RSLEAPGWEDAERREREERERLEAEE-----ERRRLQAQAQA 329
E +R REE+Q R + + E++ R+ER R EE ER Q Q
Sbjct: 1423 LSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE 1482
Query: 330 EERRRLEEDARLEERRRQEEEEGRCAEELKRQE------EEEAEGWEELEQQEAEVQGPP 383
+R+ LEE+ +L RRQE + +EL+ QE EEE + + Q++ +
Sbjct: 1483 RDRKFLEEEQQL---RRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQ 1539
Query: 384 EALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQRE 443
+E G+ RR + EEE+ Q E QLS D + RLE+Q+ + E +R+
Sbjct: 1540 LRRQERGQQRRQDRDRKFREEEQLRQEREEQ---QLSRQERDRKFRLEEQKVRRQEQERK 1596
Query: 444 HSEEPGICEEQNPEAERR--REQQGRSGDFQGADRPGPEEKREEGD-----TEPLLKQEG 496
E+ Q + + R R+++ R + +R + R+E D EP L+++
Sbjct: 1597 FMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQE 1656
Query: 497 PVEAAQPPVERK---EAAALEQGRKVEELRWQEVDER 530
+ + +RK E L++G + ++LR QE D +
Sbjct: 1657 REQQLRHDRDRKFREEEQLLQEGEE-QQLRRQERDRK 1692
Score = 87.0 bits (214), Expect = 1e-16
Identities = 101/377 (26%), Positives = 167/377 (44%), Gaps = 44/377 (11%)
Query: 151 RLDNSAAKHKLAVKPKKQRVSKKHRRLAQDPQH---EQGGLESRPCLDQNGHPGEDKPTW 207
+L K ++ +K R ++ R+ +D Q ++G + R D+ ED+
Sbjct: 1571 QLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFR--EDEQLL 1628
Query: 208 HEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAA------EKRRLEEQRLQ-ALERRL 260
E E L +E R+ + E E + +RQ+ E K R EEQ LQ E++L
Sbjct: 1629 QEREEQQLHRQERDRK----FLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQL 1684
Query: 261 WEENRRQELLEEEGEGQEPPLEAERAPREEQQR--SLEAPGWEDAERREREERERLEAEE 318
+ R ++ EEE + + E + E+Q R LE E+ + R+ E+E+L +E
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE 1744
Query: 319 ------ERRRLQAQAQAEERRRLEEDA--RLEERRRQEEEEGRCAEELKRQEEEEAEGWE 370
E +L+ + + ++ RR E D R EE+ RQE EE ++L+ QE + E
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREE----QQLRSQESDRKFREE 1800
Query: 371 ELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSE--LLNDFEE 428
E +QE E Q + + +G+ EEE L EE+E + E R +E +
Sbjct: 1801 EQLRQEREEQ---QLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKS 1857
Query: 429 RLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDT 488
R E+QE + E Q+ E E++ +++ EQ+ R E K +EG
Sbjct: 1858 RREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVG---------EIKSQEGKG 1908
Query: 489 EPLLKQEGPVEAAQPPV 505
L + G + A PV
Sbjct: 1909 HGRLLEPGTHQFASVPV 1925
Score = 85.1 bits (209), Expect = 4e-16
Identities = 87/331 (26%), Positives = 154/331 (46%), Gaps = 35/331 (10%)
Query: 209 EEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQE 268
E E L+ E++ RQ+ + L+ + + ++ E ++RR + R E +L +E Q+
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ 1571
Query: 269 LLEEEGEGQEPPLEAERAPREEQQRS-------LEAPGWEDAERREREERERLEAE--EE 319
L +E + ++ LE ++ R+EQ+R L + R+ER+ + R + + +E
Sbjct: 1572 LSRQERD-RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQE 1630
Query: 320 RRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEV 379
R Q Q +R+ LEE+ +L RR++ E++ R + K +EEE+ +E E+Q+
Sbjct: 1631 REEQQLHRQERDRKFLEEEPQL--RRQEREQQLRHDRDRKFREEEQL--LQEGEEQQLRR 1686
Query: 380 QGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPE 439
Q E EE+ L +E E + E+ + + EL F E + ++ + E
Sbjct: 1687 QERDRKFRE--------EEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738
Query: 440 GQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEK--REEGDTEPLLKQEGP 497
R I EE+ ER +Q R Q DR EE+ R+E + + L QE
Sbjct: 1739 QLRRQERYRKILEEEQLRPEREEQQLRR----QERDRKFREEEQLRQEREEQQLRSQESD 1794
Query: 498 VEAAQPPVERKEAAALEQGRKVEELRWQEVD 528
+ +E L Q R+ ++LR Q+ D
Sbjct: 1795 RKF-------REEEQLRQEREEQQLRPQQRD 1818
Score = 70.9 bits (172), Expect = 7e-12
Identities = 80/281 (28%), Positives = 131/281 (46%), Gaps = 35/281 (12%)
Query: 276 GQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEE--ERRRLQAQAQAEERR 333
GQ L+ E+ R + + SL ++ ++R E R+R EE +RRR + Q Q E
Sbjct: 90 GQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELA 149
Query: 334 RLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQG---------PPE 384
EE + +ER Q + + R EEL RQ +E E EE +E ++Q P E
Sbjct: 150 EGEEQSEKQERLEQRDRQRR-DEELWRQRQEWQER-EERRAEEEQLQSCKGHETEEFPDE 207
Query: 385 ALEETGE----GRRGAEEEDLGEEEEEGQAHLE----DWRGQLSELLNDFEERLEDQERL 436
E R+G EE+ E + + E +WR + +L EE+L+++E
Sbjct: 208 EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWR-KRETVLRKEEEKLQEEE-- 264
Query: 437 KPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEE----KREEGDTEPLL 492
P+ QRE EE EEQ + ER+ ++ R + Q R E+ K+EE E
Sbjct: 265 -PQRQRELQEE----EEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE 319
Query: 493 KQEGPVEAAQPPVERKEAAAL--EQGRKVEELRWQEVDERQ 531
++ E + ER+E ++ R+ ++LR ++ +ER+
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERR 360
Score = 40.4 bits (93), Expect = 0.011
Identities = 43/185 (23%), Positives = 75/185 (40%), Gaps = 8/185 (4%)
Query: 992 RAGRPDPEPSEPSKEDQESSDRR-PPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQ 1050
+ R D + S QE RR P EE GQ+R ++ + ER+ A + +Q
Sbjct: 99 KRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQ 158
Query: 1051 EKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQKGFREQQATREE- 1109
E+ Q R E+ Q + + + E+ + L + ++ E+Q R E
Sbjct: 159 ERLEQRDRQRRDEELWRQRQ---EWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 1110 ---RKQAREAKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPETAVSRLERR 1166
R++ RE KQ ++ +++ + R L K +E+ P+ E
Sbjct: 216 LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275
Query: 1167 EQLKK 1171
EQL+K
Sbjct: 276 EQLRK 280
Score = 40.4 bits (93), Expect = 0.011
Identities = 73/349 (20%), Positives = 126/349 (36%), Gaps = 53/349 (15%)
Query: 851 RTNYSLRFNCDQQAEQKKKKRHSSTGDSADAGPPAAGSARGEKEMEGVALKHGPSLPQER 910
R L+ +++ EQ+ K+ + + E+E LK S QE
Sbjct: 585 RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLK---SEEQEE 641
Query: 911 KQAPSTRRDSAEPSSSRSVPVAHPGPPPASSQTPAPEHDKAANKMPLAQKPALAPKPTSQ 970
++ RR+ E R + Q EH++ + LA++ + ++
Sbjct: 642 RRQQQLRREQQERREQR---LKREEEEERLEQRLKREHEEERREQELAEEE----QEQAR 694
Query: 971 TPPASPLSKLSRPYLVELLSRRA---GRPDPEPSEPSKEDQESSDRRPPSP-PGPEERKG 1026
S + K E +R++ RP + + +++QE RR S EE +
Sbjct: 695 ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERA 754
Query: 1027 QKRDEEEE-----------------ATERKPASPPL----------PATQQEKPSQTPEA 1059
++ +EEE +R A PPL QQ + PE
Sbjct: 755 HRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEE 814
Query: 1060 GRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQK-GFREQQATREERKQAREAKQ 1118
KE+ Q R + E+ E Q LQ+++ G +E Q R ++Q R+ K
Sbjct: 815 EEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874
Query: 1119 AEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPETAVSRLERRE 1167
+L +E R +L+ AL E+ R E + + E E
Sbjct: 875 RWQLEEER-----------KRRRHTLYAKPALQEQLRKEQQLLQEEEEE 912
Score = 37.0 bits (84), Expect = 0.12
Identities = 45/171 (26%), Positives = 76/171 (44%), Gaps = 8/171 (4%)
Query: 1005 KEDQESSDRRPPS-PPGPEERKGQ--KRDEEEEATERKPAS-PPLPATQQEKPSQTPEAG 1060
+E +E +RR EER+ Q KR EEEE +++ S L Q+E+ Q +
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK-- 551
Query: 1061 RKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQKGFREQQATREERKQAREAKQAE 1120
R+E+ L+ K ++ Q L ++Q+ REQ+ E+R + E ++ E
Sbjct: 552 REEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLE 611
Query: 1121 KLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPETAVSRLERREQLKK 1171
+ +E ++ R L KS E ++ + + ERREQ K
Sbjct: 612 Q--EERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Score = 36.6 bits (83), Expect = 0.15
Identities = 51/213 (23%), Positives = 87/213 (40%), Gaps = 42/213 (19%)
Query: 979 KLSRPYLVELLSRRAGRPDPEPSEPSKEDQ-------------ESSDRRPPSPPGPEERK 1025
+L R L+EL RR GR + + ++D+ E+ R+ EE +
Sbjct: 209 QLRRRELLEL--RRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266
Query: 1026 GQKRDEEEEATERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETA 1085
Q+ +EEE RK L +QE+ Q R++ +L K E
Sbjct: 267 RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQ-------------QLRRKQEEE 313
Query: 1086 QPLWITLALQKQKGFREQQATREERKQAREAKQAEKLSKENVSVSVQPGSSSVSRAGSLH 1145
+ ++Q+ REQQ RE++++ RE +Q + +E ++ R L
Sbjct: 314 R-------REQQEERREQQERREQQEERRE-QQLRREQEERREQQLRREQEEERREQQLR 365
Query: 1146 KSTALPEEKRPETAVSR---LERREQLKKANTL 1175
+ EE+R E + R L R +QL++ L
Sbjct: 366 RE---QEEERREQQLRREQQLRREQQLRREQQL 395
Score = 34.7 bits (78), Expect = 0.58
Identities = 30/129 (23%), Positives = 58/129 (44%), Gaps = 12/129 (9%)
Query: 1002 EPSKEDQESSDRRPPSPPGPEERKGQKRDEE-----------EEATERKPASPPLPATQQ 1050
E ++++E R P +ER+ Q R+EE EE +R+ ++
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143
Query: 1051 EKPSQTPEAGRKEKPMLQSRHSLDGS-KLTEKVETAQPLWITLALQKQKGFREQQATREE 1109
E+ Q E +E+P + R L+ + E+++ + + +K++ RE+Q EE
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEE 1203
Query: 1110 RKQAREAKQ 1118
Q ++ KQ
Sbjct: 1204 ELQRQKRKQ 1212
Score = 34.7 bits (78), Expect = 0.58
Identities = 35/143 (24%), Positives = 61/143 (42%), Gaps = 18/143 (12%)
Query: 998 PEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPA------SPPLPATQQE 1051
PE + +E+Q+ + RR +E K R+E EE R+ L ++E
Sbjct: 1294 PEEEQLEREEQKEAKRRDRK---SQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE 1350
Query: 1052 KPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQKGF--REQQATREE 1109
+P + E RK + + RH G K E+ + + ++++ F EQQ +E
Sbjct: 1351 QPLRRQERDRKFREE-ELRHQEQGRKFLEEEQRLR------RQERERKFLKEEQQLRCQE 1403
Query: 1110 RKQAREAKQAEKLSKENVSVSVQ 1132
R+Q + K +E +S Q
Sbjct: 1404 REQQLRQDRDRKFREEEQQLSRQ 1426
Score = 34.3 bits (77), Expect = 0.75
Identities = 28/124 (22%), Positives = 56/124 (45%), Gaps = 16/124 (12%)
Query: 1002 EPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPEAGR 1061
E + +QE ++ E R+ + EEEE E QQE+ Q +
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE-----------QQERREQQLRREQ 511
Query: 1062 KEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQKGFREQQATREERKQAREAKQAEK 1121
+E+ + + + +L +++ + Q L ++Q+ REQ REE K+ + ++ ++
Sbjct: 512 EERREQRLKRQEEEERLQQRLRSEQQL-----RREQEERREQLLKREEEKRLEQERREQR 566
Query: 1122 LSKE 1125
L +E
Sbjct: 567 LKRE 570
Score = 33.5 bits (75), Expect = 1.3
Identities = 32/151 (21%), Positives = 67/151 (44%), Gaps = 15/151 (9%)
Query: 1027 QKRDEEEEATERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQ 1086
++R EEE+ +R L Q+E+ + E R+++ + + +L + E +
Sbjct: 288 RERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR 347
Query: 1087 PLWITLALQKQKGFREQQATREERKQARE--AKQAEKLSKENVSVSVQPGSSSVSRAGSL 1144
L ++++ REQQ RE+ ++ RE ++ ++L +E + R L
Sbjct: 348 EQ--QLRREQEEERREQQLRREQEEERREQQLRREQQLRRE----------QQLRREQQL 395
Query: 1145 HKSTALPEEKRPETAVSRLERREQLKKANTL 1175
+ L E++ +L R +QL++ L
Sbjct: 396 RREQQLRREQQLRRE-QQLRREQQLRREQQL 425
Score = 33.1 bits (74), Expect = 1.7
Identities = 27/147 (18%), Positives = 64/147 (43%)
Query: 1022 EERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEK 1081
+ER+ ++ +EE+ + + + P +Q + + E RK + Q + ++ ++
Sbjct: 181 QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQE 240
Query: 1082 VETAQPLWITLALQKQKGFREQQATREERKQAREAKQAEKLSKENVSVSVQPGSSSVSRA 1141
E + L+K++ +++ + +R+ E +Q KL ++ + Q R
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL 300
Query: 1142 GSLHKSTALPEEKRPETAVSRLERREQ 1168
+ EE+R E R E++E+
Sbjct: 301 RREQQLRRKQEEERREQQEERREQQER 327
Score = 33.1 bits (74), Expect = 1.7
Identities = 35/186 (18%), Positives = 81/186 (43%), Gaps = 16/186 (8%)
Query: 995 RPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQEKPS 1054
+ + E E +E +E +RR E R+ Q R E+EE E++ ++++
Sbjct: 309 KQEEERREQQEERREQQERREQQE---ERREQQLRREQEERREQQLRREQEEERREQQLR 365
Query: 1055 QTPEAGRKEKPMLQSRHSLDGSKLT--------EKVETAQPLWITLALQKQKGFR-EQQA 1105
+ E R+E+ + + + +L +++ Q L L++++ R EQQ
Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 425
Query: 1106 TREERKQAREAKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPETAVSRLER 1165
RE+ ++ E K ++ ++ + + + R + T E++R + + R +
Sbjct: 426 RREQEEERHEQKHEQERREQRLKREQEERRDWLKR----EEETERHEQERRKQQLKRDQE 481
Query: 1166 REQLKK 1171
E+ ++
Sbjct: 482 EERRER 487
Score = 32.0 bits (71), Expect = 3.7
Identities = 25/135 (18%), Positives = 59/135 (43%), Gaps = 4/135 (2%)
Query: 991 RRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQ 1050
RR + + + +E QE + E R+ Q R E+EE + ++
Sbjct: 314 RREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR 373
Query: 1051 EKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQKGFREQQATREER 1110
E+ + + R+E+ + + + + +++ Q L L++++ R +Q R E+
Sbjct: 374 EQQLRREQQLRREQQLRREQQ----LRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 429
Query: 1111 KQAREAKQAEKLSKE 1125
++ R ++ E+ +E
Sbjct: 430 EEERHEQKHEQERRE 444
Score = 32.0 bits (71), Expect = 3.7
Identities = 34/148 (22%), Positives = 61/148 (41%), Gaps = 19/148 (12%)
Query: 987 ELLSRRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQ--KRDEEEEATERKPASPP 1044
+LL R + + + +E +RR EER+ Q KR++EE +R
Sbjct: 548 QLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEV 607
Query: 1045 LPATQQEKPSQT-----PEAGRKEKPM------------LQSRHSLDGSKLTEKVETAQP 1087
Q+E+ Q PE R+++ + L+ + ++ E +
Sbjct: 608 ERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEER 667
Query: 1088 LWITLALQKQKGFREQQATREERKQARE 1115
L L + ++ REQ+ EE++QARE
Sbjct: 668 LEQRLKREHEEERREQELAEEEQEQARE 695
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 110 bits (275), Expect = 8e-24
Identities = 95/394 (24%), Positives = 191/394 (48%), Gaps = 18/394 (4%)
Query: 152 LDNSAAKHKLAVKPKKQRVSKKHRRLAQDPQ-HEQGGL---ESRPCLDQNGHPGEDKPTW 207
++ ++ +L +K K+++ L Q+ Q EQ G + +Q G E +
Sbjct: 23 VETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 82
Query: 208 HEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKR-RLEEQRLQALERRLWEENRR 266
E+E + E + R QE RE E + + Q+ + E+ ++ EQ Q E+ +
Sbjct: 83 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 142
Query: 267 QELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQ 326
++ E+EG+ +E E + +E Q R E E + +E + E E + + Q
Sbjct: 143 GQVREQEGQVREQ--EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQ 200
Query: 327 AQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEAL 386
+E + E++ E+ ++QEE+ G E++++QEE+ E E++++QE +VQ E +
Sbjct: 201 MGEQEEQMGEQE---EQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQM 257
Query: 387 EETGEGRRGAEEEDLGEEE----EEGQAHLEDWRGQLSELLNDFEERLEDQE---RLKPE 439
+ E R EE+ +EE ++ Q E+ G+ E + + EE++ +QE R + E
Sbjct: 258 RKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEE 317
Query: 440 GQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVE 499
RE E+ G EEQ E + + +Q + ++ ++ G +E++ + E + KQE +
Sbjct: 318 QMREQEEQMGKQEEQMWEQKEQMWEQ-KEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMR 376
Query: 500 AAQPPVERKEAAALEQGRKVEELRWQEVDERQTM 533
+ + ++E +Q ++ E + Q ++++ M
Sbjct: 377 KQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQM 410
Score = 102 bits (253), Expect = 3e-21
Identities = 87/331 (26%), Positives = 157/331 (47%), Gaps = 31/331 (9%)
Query: 195 DQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKR-RLEEQRL 253
+Q G E + E+E + E + R QE RE E + + Q+ + E+ ++ EQ
Sbjct: 126 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 185
Query: 254 QALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERER 313
Q R QE E EGQ E + +EEQ + E E E+ ++E +
Sbjct: 186 QV---------REQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQM 236
Query: 314 LEAEE--ERRRLQAQAQAEERRRLEEDAR-LEERRRQEEEEGRCAEELKRQEEEEAEGWE 370
E EE +++ Q Q Q E+ R+ EE R EE+ R++EE+ +E QEE+ E E
Sbjct: 237 GEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEE 296
Query: 371 ELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERL 430
++ +QE +++ E + E E R +EE +G++EE+ E Q ++ E+
Sbjct: 297 QMREQEEQMREQEEQMREQEEQMR-EQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMG 355
Query: 431 EDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEP 490
E +E+++ + ++ +E + +++ E R++E+Q R + Q E+K + G+ +
Sbjct: 356 EQEEQMQKQEEQVRKQEEQMRKQE--EQMRKQEEQMRKQEEQMG-----EQKEQMGEQKE 408
Query: 491 LLKQEGPVEAAQPPVERKEAAALEQGRKVEE 521
++++ E + EQ RK EE
Sbjct: 409 QMREQ----------EEQMGEQKEQMRKQEE 429
Score = 95.5 bits (236), Expect = 3e-19
Identities = 61/250 (24%), Positives = 132/250 (52%), Gaps = 13/250 (5%)
Query: 195 DQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQ 254
+Q G GE + E+E + EE+ ++QE+ E E + ++Q+ + E+ +++ +
Sbjct: 189 EQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEE 248
Query: 255 ALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERL 314
++++ E+ R+QE E E Q E + ++EQ E G ++ + RE+EE+ R
Sbjct: 249 QVQKQE-EQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMRE 307
Query: 315 EAEEERRRLQAQAQAEERRRLEEDARLEERR----------RQEEEEGRCAEELKRQEEE 364
+ E+ R + + + EE+ +E+ E++ +QEE+ G E++++QEE+
Sbjct: 308 QEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQ 367
Query: 365 EAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLN 424
+ E++ +QE +++ E + + E + G ++E +GE++E+ E+ G+ E +
Sbjct: 368 VRKQEEQMRKQEEQMRKQEEQMRKQEE-QMGEQKEQMGEQKEQ-MREQEEQMGEQKEQMR 425
Query: 425 DFEERLEDQE 434
EE + +Q+
Sbjct: 426 KQEEHMGEQK 435
Score = 94.0 bits (232), Expect = 8e-19
Identities = 70/253 (27%), Positives = 131/253 (51%), Gaps = 15/253 (5%)
Query: 195 DQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQ 254
+Q G GE + E+E EE+ QE+ R+ E Q E E+ + +E+++Q
Sbjct: 196 EQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQE----EQMGEQEEQVQKQEEQVQ 251
Query: 255 ALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERL 314
E E+ R+QE E E Q E + ++EQ E G ++ + RE+EE+ R
Sbjct: 252 KQE----EQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMR- 306
Query: 315 EAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQ 374
E EE+ R + Q + +E + +++ ++ E++ Q E+ E++ +QEE+ E E++++
Sbjct: 307 EQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQ---KEQMWKQEEQMGEQEEQMQK 363
Query: 375 QEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQE 434
QE +V+ E + + E R EE+ +EE+ G+ ++ G+ E + + EE++ +Q+
Sbjct: 364 QEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQ--KEQMGEQKEQMREQEEQMGEQK 421
Query: 435 RLKPEGQREHSEE 447
+ Q EH E
Sbjct: 422 E-QMRKQEEHMGE 433
Score = 93.2 bits (230), Expect = 1e-18
Identities = 62/225 (27%), Positives = 113/225 (50%), Gaps = 6/225 (2%)
Query: 182 QHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAE 241
Q EQ G + Q GE + ++E EE+ R+QE+ RE E + + Q+ +
Sbjct: 218 QEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQ 277
Query: 242 AAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWE 301
+++ EQ Q E+ E+ R QE E E Q E + +EEQ E WE
Sbjct: 278 MLKQKEQTEQEEQTGEQE--EQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWE 335
Query: 302 DAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQ 361
E+ ++ + + EE+ + Q Q +E + +++ E+ R+QEE+ + E++++Q
Sbjct: 336 QKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQE---EQMRKQEEQMRKQEEQMRKQ 392
Query: 362 EEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEE 406
EE+ E E++ +Q+ +++ E + E E R +EE +GE++E
Sbjct: 393 EEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMR-KQEEHMGEQKE 436
Score = 91.3 bits (225), Expect = 5e-18
Identities = 67/288 (23%), Positives = 132/288 (45%), Gaps = 12/288 (4%)
Query: 195 DQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRL---EEQ 251
+Q G E + E+E + E + R QE RE E + Q+ + E+ +E+
Sbjct: 154 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEE 213
Query: 252 RLQALERRLWEEN---RRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERRER 308
++Q E ++ E+ R+QE E E Q E + +EEQ R E E E+
Sbjct: 214 QMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMRE 273
Query: 309 EERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEG 368
+E + L+ +E+ + + + EE+ R +E+ E+ + E+E + E+ ++ ++E +
Sbjct: 274 QEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQM 333
Query: 369 WEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEE 428
WE+ EQ + + + E+ GE +E+ +++EE E+ + E + EE
Sbjct: 334 WEQKEQMWEQKEQMWKQEEQMGE------QEEQMQKQEEQVRKQEEQMRKQEEQMRKQEE 387
Query: 429 RLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADR 476
++ QE E + + E+ EQ + ++EQ + + G +
Sbjct: 388 QMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQK 435
Score = 84.7 bits (208), Expect = 5e-16
Identities = 59/231 (25%), Positives = 123/231 (53%), Gaps = 16/231 (6%)
Query: 182 QHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAE 241
Q EQ G + Q GE + ++E + EE+ ++QE+ ++ E + ++Q+
Sbjct: 204 QEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQE-- 261
Query: 242 AAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWE 301
E+ R +E++++ E ++ ++ + E E+ GE +E E E RE++++ E
Sbjct: 262 --EQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQ---- 315
Query: 302 DAERREREERERLEAEEER---RRLQAQAQAEERRRLEEDARLEERRRQEEEE--GRCAE 356
E + RE+ E++ +EE+ ++ Q Q E+ + EE +E + Q++EE + E
Sbjct: 316 --EEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEE 373
Query: 357 ELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEE 407
++++QEE+ + E++ +QE ++ E + E E R +EE +GE++E+
Sbjct: 374 QMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMR-EQEEQMGEQKEQ 423
Score = 73.2 bits (178), Expect = 1e-12
Identities = 51/205 (24%), Positives = 104/205 (50%), Gaps = 14/205 (6%)
Query: 163 VKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERR 222
V+ ++++V K+ ++ + Q EQ + +Q + K +EE + EE+ R
Sbjct: 243 VQKQEEQVQKQEEQMRK--QEEQMREQEEQMREQEEQMLKQKEQTEQEEQTG-EQEEQMR 299
Query: 223 RQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLE 282
QE+ RE E + + Q+ E+ R +E+++ E ++WE+ + +E+ QE
Sbjct: 300 EQEEQMREQEEQMREQE----EQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQE---- 351
Query: 283 AERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLE 342
E+ +E+Q + E + R++ E++ +EE+ R Q + E++ ++ E + E
Sbjct: 352 -EQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGE--QKE 408
Query: 343 ERRRQEEEEGRCAEELKRQEEEEAE 367
+ R QEE+ G E++++QEE E
Sbjct: 409 QMREQEEQMGEQKEQMRKQEEHMGE 433
Score = 72.0 bits (175), Expect = 3e-12
Identities = 83/351 (23%), Positives = 156/351 (44%), Gaps = 62/351 (17%)
Query: 241 EAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGW 300
E EK ++ LQ +E E + L+ + E + PL E RE++ + E G
Sbjct: 8 ELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQ 67
Query: 301 ---EDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEER----RRQE----E 349
++ + RE+E + R E E + R + Q + +E + E++ ++ E+ R QE E
Sbjct: 68 VREQEGQVREQEGQVR-EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 126
Query: 350 EEGRCAE---ELKRQEEEEAEGWEELEQQEAEV-QGPPEALEETG--------------- 390
+EG+ E +++ QE + E ++ +QE +V + + E+ G
Sbjct: 127 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 186
Query: 391 -----------EGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERL--------- 430
EG+ G +EE +GE+EE+ Q E+ G+ E + EE++
Sbjct: 187 VREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQ-EEQMGEQEEQMRKQEEQMGEQEEQVQK 245
Query: 431 --------EDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEK 482
E+Q R + E RE E+ EEQ + + + EQ+ ++G+ + R E+
Sbjct: 246 QEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQM 305
Query: 483 REEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQTM 533
RE+ E + +QE + + + ++E EQ ++ E + Q + + M
Sbjct: 306 REQ--EEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQM 354
Score = 59.7 bits (143), Expect = 2e-08
Identities = 64/295 (21%), Positives = 140/295 (47%), Gaps = 21/295 (7%)
Query: 267 QELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQ 326
+EL E+ E QE E + E+ + L ++ +R+ ++ L E + R + Q
Sbjct: 7 EELKEKNAELQE---ELQLVETEKSEIQLHI---KELKRKLETDKIPLPQEGQVREQEGQ 60
Query: 327 AQAEERRRLEEDARLEERR---RQEEEEGRCAE-ELKRQEEEEAEGWEELEQQEAEVQGP 382
+ +E + E++ ++ E+ R++E + R E +++ QE + E ++ +QE +V+
Sbjct: 61 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 120
Query: 383 PEALEETGEGRRGAEEEDLGEEE---EEGQAHLEDWRGQLSE---LLNDFEERLEDQERL 436
+ E EG+ +E + E+E E + + + GQ+ E + + E ++ +QE
Sbjct: 121 EGQVREQ-EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 179
Query: 437 KPEGQREHSEEPGICEEQNPEAERRREQQGRSGD--FQGADRPGPEEKREEGDTEPLLKQ 494
E + + E+ G EQ + + EQ G + + ++ G +E++ E + +Q
Sbjct: 180 VREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQ 239
Query: 495 EGPVEAAQPPVERKEAAALEQGRKV--EELRWQEVDERQTMPRPYTFQVSSGGKQ 547
E V+ + V+++E +Q ++ +E + +E +E+ + T Q G+Q
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQ 294
Score = 36.6 bits (83), Expect = 0.15
Identities = 36/180 (20%), Positives = 74/180 (41%), Gaps = 11/180 (6%)
Query: 999 EPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPE 1058
+ E QE R +E + K+ E+ E E+ Q+E+ + E
Sbjct: 251 QKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEE 310
Query: 1059 AGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQKGFR--EQQATREERKQARE- 1115
R+++ ++ + G + + E + +W QK++ ++ EQ +EE+ Q +E
Sbjct: 311 QMREQEEQMREQEEQMGKQEEQMWEQKEQMW----EQKEQMWKQEEQMGEQEEQMQKQEE 366
Query: 1116 --AKQAEKLSKENVSVSVQPGS--SSVSRAGSLHKSTALPEEKRPETAVSRLERREQLKK 1171
KQ E++ K+ + Q + G + +E+ E E++EQ++K
Sbjct: 367 QVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRK 426
Score = 33.9 bits (76), Expect = 0.98
Identities = 25/127 (19%), Positives = 59/127 (46%), Gaps = 13/127 (10%)
Query: 999 EPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPE 1058
+ E +QE R+ G +E + QK++E+ + E + + +++ Q +
Sbjct: 216 QKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQ-----MRKQEEQMREQEEQ 270
Query: 1059 AGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQKGFREQQATREERKQAREAKQ 1118
+E+ ML+ + + + T + E + Q+++ +++ RE+ +Q RE Q
Sbjct: 271 MREQEEQMLKQKEQTEQEEQTGEQEEQ------MREQEEQMREQEEQMREQEEQMRE--Q 322
Query: 1119 AEKLSKE 1125
E++ K+
Sbjct: 323 EEQMGKQ 329
Score = 30.8 bits (68), Expect = 8.3
Identities = 25/126 (19%), Positives = 56/126 (44%), Gaps = 13/126 (10%)
Query: 1006 EDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPEAGRKEKP 1065
E +E + EE+ G++ ++ + E+ Q+E+ + E RK++
Sbjct: 203 EQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEE 262
Query: 1066 MLQSR----HSLDGSKLTEKVETAQPLWITLALQKQKGFREQQATREERKQAREAKQAEK 1121
++ + + L +K +T Q ++Q G +E+Q RE+ +Q RE ++ +
Sbjct: 263 QMREQEEQMREQEEQMLKQKEQTEQ--------EEQTGEQEEQ-MREQEEQMREQEEQMR 313
Query: 1122 LSKENV 1127
+E +
Sbjct: 314 EQEEQM 319
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 108 bits (270), Expect = 3e-23
Identities = 207/981 (21%), Positives = 359/981 (36%), Gaps = 122/981 (12%)
Query: 242 AAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWE 301
A R E+++LQAL R + LE LE E A +QQ A G
Sbjct: 90 AVATSRSEKEQLQALNDRFAGYIDKVRQLEAHNRS----LEGEAAALRQQQAGRSAMG-- 143
Query: 302 DAERREREERE------RLEAEEERRRLQAQAQAEE----RRRLEEDARLEE-------- 343
E ERE RE RL A + RL+ + E+ R+RL+++AR E
Sbjct: 144 --ELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARA 201
Query: 344 --RRRQEEEEGRCAEELKRQEEEEAEGW------EELEQQEAEVQGPPEALEETGEGRRG 395
R QE E R + K Q +E G+ EE+ + ++QG A + R
Sbjct: 202 LARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRD 261
Query: 396 AEEEDLGEEEEEGQAHLEDWRGQLS----ELLNDFEERLEDQERLKPEGQREHSEEPGIC 451
A + D+ E +A LE Q + E +RL + ++ + R EE
Sbjct: 262 ALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEI--- 318
Query: 452 EEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAA 511
E RR+ Q R+ + + +R+ + E + + + + Q +++ +A
Sbjct: 319 ------TEYRRQLQARTTELEALKSTKDSLERQRSELED--RHQADIASYQEAIQQLDAE 370
Query: 512 ALEQGRKVEELRWQEVDERQTMPRPYTFQVSSGGKQILFP--KVNLSPVTPAKDTGLTAA 569
L + + +E + + ++++ K + ++ P+ + GL
Sbjct: 371 -LRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKI 429
Query: 570 PQEPKAPKASPVQHALPSSLSVPHTAILVTGAQLCGPAVNLSQIKDTACKSLLGLEEK-- 627
P K + S T I+ + +++ ++ K G EE+
Sbjct: 430 PSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGG 489
Query: 628 KHAEAPAGENPPRGPGDARAGSGKAK-----------------PRQESPSSASALAEWAS 670
+ EA GE + P A S + + P +E S + +
Sbjct: 490 EEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEK 549
Query: 671 IRSRILKNAESDP--RSSERDQLRPGDESTPRGRCDSRGNQRKTPPVNAKFSIMPAWQKF 728
+S + A+S P +S E+++ + E + S + P AK +K
Sbjct: 550 AKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSP-----EKA 604
Query: 729 SDGGTETSKQSTEAESIRKRPMLGPSEETAPQPPPAGVRELGKGPEKSEM-HREPADTTE 787
E +K EA+S K P+E +P+ + +E K PEK++ +E A + E
Sbjct: 605 KSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE 664
Query: 788 GCKFAKDLPSFLVPSLPYPPQKVVAHTEFTTSSDSETANGIAKPDPVMPGGEEKASPFGI 847
K + P + E S E A K P EE SP
Sbjct: 665 KAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKS--PVKEEAKSPEKA 722
Query: 848 KL-----RRTNYSLRFNCDQQAEQKKKKRHSSTGDSADAGPPAAGSARGEKEMEGVALKH 902
K +T + ++A+ +K + + D P A + E+ A
Sbjct: 723 KSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE-----ARSP 777
Query: 903 GPSLPQERKQAPSTRRDSAEPSSSRSVPVAHPGPPPASSQTPAPEHDKAANK---MPLAQ 959
P++ K S E + S P+ P + P E K+ K P
Sbjct: 778 ADKFPEKAKSPVKEEVKSPEKAKS---PLKEDAKAP-EKEIPKKEEVKSPVKEEEKPQEV 833
Query: 960 KPALAPKPTSQTP-PASPLSKLSRPYLVELLSRRAGRPDPEPSEPSKEDQESSDRRPPSP 1018
K PK + PA+P ++ + S++ P E +P E+++ P
Sbjct: 834 KVKEPPKKAEEEKAPATPKTEEKKD------SKKEEAPKKEAPKPKVEEKKEPAVEKPKE 887
Query: 1019 PGPEERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKL 1078
E +K + D+++ T K A + + KP + E +KE +++ + SK
Sbjct: 888 SKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAK---EPSKP 944
Query: 1079 TEKVETAQPLWITLALQKQKGFREQQATREERKQAREAKQAEKLSKENVSVSVQPGSSSV 1138
EK E A ++K +E++A + E K EAK E ++ ++S +P
Sbjct: 945 AEKKEAAP---------EKKDTKEEKAKKPEEKPKTEAKAKE----DDKTLSKEPSKPKA 991
Query: 1139 SRAGSLHKSTALPEEKRPETA 1159
+A ST + K PE A
Sbjct: 992 EKAEK-SSSTDQKDSKPPEKA 1011
Score = 88.2 bits (217), Expect = 4e-17
Identities = 190/899 (21%), Positives = 342/899 (38%), Gaps = 135/899 (15%)
Query: 218 EEERRRQEDYWRELEAKCKRQKAEAAEKRRLE-EQRLQALERRLWEENRRQELLEEEGE- 275
+E R+R+E E A+ + A+ AE R++ +++ QAL+ R + EE GE
Sbjct: 187 DEARQREE---AEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQ--EEVGEL 241
Query: 276 -GQEPPLEAERAPREEQQR-SLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERR 333
GQ A +A + + R +L+ D RE R +LE +Q+ Q+EE
Sbjct: 242 LGQIQGSGAAQAQMQAETRDALKC----DVTSALREIRAQLEGHA----VQSTLQSEEWF 293
Query: 334 RLEEDARLEERRRQEEEEGRCAEE----LKRQEEEEAEGWEELEQQEAEVQGPPEALEET 389
R+ D RL E + + R A+E +RQ + E L+ + ++ LE+
Sbjct: 294 RVRLD-RLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDR 352
Query: 390 GEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSE---LLN----------DFEERLEDQE-- 434
+ + +E + + + E + + QL E LLN + + LE +E
Sbjct: 353 HQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECR 412
Query: 435 ------------------------RLKPEGQ----REHSEEPGICEEQNPEA----ERRR 462
++K E + + +E I EEQ E E
Sbjct: 413 IGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTE 472
Query: 463 EQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEEL 522
E++ + + +G + G EE+ EG E + P E A P + ++ E+ + E
Sbjct: 473 EEEKEAKEEEGKEEEGGEEEEAEGGEEET--KSPPAEEAASPEKEAKSPVKEEAKSPAEA 530
Query: 523 RWQEVDERQTMPRPYTFQVSSGGKQILFPKVNLSPVTPAKDTGLTAAPQEPKAPKA---- 578
+ E +E ++ +V S K +PAK+ +P E K+P+
Sbjct: 531 KSPEKEEAKSPA-----EVKSPEKA----------KSPAKEEA--KSPPEAKSPEKEEAK 573
Query: 579 SPVQHALPSSLSVPHTAILVTGAQLCGPAVNLSQIKDTACKSLLGLEE--KKHAEAPAGE 636
SP + P P + A+ P S +K+ A KS + K+ A++PA
Sbjct: 574 SPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEA-KSPAEAKSPVKEEAKSPAEV 632
Query: 637 NPPRGPGDARAGSGKAKPRQESPSSASALAEWASIRSRILKNAESDPRSSERDQLRPGDE 696
P K+ + +SP E A + +++ +S E+ + E
Sbjct: 633 KSPEKAKSPTKEEAKSPEKAKSPEK-----EEAKSPEKAKSPVKAEAKSPEKAKSPVKAE 687
Query: 697 STPRGRCDSRGNQRKTPPVNAKFSIMPAWQKFSDGGTETSKQSTEAESIRKRPMLGPSEE 756
+ + S + P AK + E +K +A+S K P +
Sbjct: 688 AKSPEKAKSPVKEEAKSPEKAKSPVK-----------EEAKSPEKAKSPVKEEAKTPEKA 736
Query: 757 TAPQPPPAGVRELGKGPEKSEMH--REPADTTEGCKFAKDLPSFLVPSLPYPPQKVVAHT 814
+P A E K PEK++ + P T + A+ P ++ V
Sbjct: 737 KSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSP 796
Query: 815 EFTTSSDSETANGIAKPDPVMPGGEEKASPFGIKLRRTNYSLRFNCDQQAEQKKKKRHSS 874
E S E A P+ +P EE SP + + ++ ++AE++K
Sbjct: 797 EKAKSPLKEDAKA---PEKEIPKKEEVKSPVKEEEKPQEVKVK-EPPKKAEEEKAPATPK 852
Query: 875 TGDSADAGPPAAGSARGEKEMEGVALKHGPSLPQERKQAPSTRRDSAEPSSSRSVPVAHP 934
T + D+ A K V K P++ + ++ +++ AE + VP
Sbjct: 853 TEEKKDSKKEEAPKKEAPKPK--VEEKKEPAVEKPKESKVEAKKEEAE--DKKKVPTPEK 908
Query: 935 GPPPASSQTPAPEHDKAANKMPLAQKPALAPKPTSQTPPASPLSKLSRPYLVELLSRRAG 994
P ++ E K K +A+K K + PA K + P + +A
Sbjct: 909 EAP---AKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAE--KKEAAPEKKDTKEEKAK 963
Query: 995 RPDPEPSEPSK--EDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQE 1051
+P+ +P +K ED ++ + P P ++ E+ +T++K + PP AT+ +
Sbjct: 964 KPEEKPKTEAKAKEDDKTLSKEPSKPKA-------EKAEKSSSTDQKDSKPPEKATEDK 1015
Score = 58.5 bits (140), Expect = 4e-08
Identities = 140/694 (20%), Positives = 252/694 (36%), Gaps = 159/694 (22%)
Query: 202 EDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLW 261
E + T E +++EE ++E+ E ++AE E EE + E
Sbjct: 463 ETQVTEEVTEEEEKEAKEEEGKEEEGGEE-------EEAEGGE----EETKSPPAEEAAS 511
Query: 262 EENRRQELLEEE----GEGQEPPLEAERAPRE-EQQRSLEAPGWEDA----ERREREERE 312
E + ++EE E + P E ++P E + ++P E+A E + E+ E
Sbjct: 512 PEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEE 571
Query: 313 RLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQE-EEEGRCAEELKRQEEEEAEGWEE 371
E + +A++ A+E + +A+ E+ + +EE + E K +EEA
Sbjct: 572 AKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEA----- 626
Query: 372 LEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLE 431
+ AEV+ P +A T E + E+ E+EE +
Sbjct: 627 --KSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE-------------------K 665
Query: 432 DQERLKPEGQR-EHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEP 490
+ +K E + E ++ P E ++PE + ++ + E K E P
Sbjct: 666 AKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSP 725
Query: 491 LLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQTMPRPYTFQVSSGGKQILF 550
+ ++ E A+ PV ++EA + E+ + E+ + +V +
Sbjct: 726 VKEEAKTPEKAKSPV-KEEAKSPEKAKSPEKAKTLDVKSPEAK----------------- 767
Query: 551 PKVNLSPVTPAKDTGLTAAPQEPKAPKASPVQHALPSSLSVPHTAILVTGAQLCGPAVNL 610
TPAK+ + A + P+ K SPV+ + S P
Sbjct: 768 --------TPAKEEARSPADKFPEKAK-SPVKEEVKS------------------PEKAK 800
Query: 611 SQIKDTACKSLLGLEEKKHAEAPAGENPPRGPGDARAGSGKAKPRQESPSSASALAEWAS 670
S +K+ A + +K+ ++P E + KP++ AE
Sbjct: 801 SPLKEDAKAPEKEIPKKEEVKSPVKE--------------EEKPQEVKVKEPPKKAE--- 843
Query: 671 IRSRILKNAESDPRSSERDQLRPGDESTPRGRCDSRGNQRKTPPVNAKFSIMPAWQKFSD 730
+ A + P++ E+ + E P+ ++ P + PA +K +
Sbjct: 844 -----EEKAPATPKTEEKKDSK--KEEAPK---------KEAPKPKVEEKKEPAVEKPKE 887
Query: 731 GGTETSKQSTEAESIRKRPMLGPSEETAPQPPPAGVRELGKGPEKSEMHREPADTTEGCK 790
E K+ EAE +K P P +E P V+E K EK+E+ ++ D +
Sbjct: 888 SKVEAKKE--EAEDKKKVPT--PEKEA---PAKVEVKEDAKPKEKTEVAKKEPDDAK--- 937
Query: 791 FAKDLPSFLVPSLPYPPQKVVAHTEFTTSSDSETANGIAKPDPVMPGGEEKASPFGIKLR 850
AK+ PS P A + +T AK P E KA L
Sbjct: 938 -AKE------PSKP-------AEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLS 983
Query: 851 RTNYSLRFNCDQQAEQKKKKRHSSTGDSADAGPP 884
+ + + +K SS+ D D+ PP
Sbjct: 984 K---------EPSKPKAEKAEKSSSTDQKDSKPP 1008
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 107 bits (268), Expect = 5e-23
Identities = 111/420 (26%), Positives = 201/420 (47%), Gaps = 45/420 (10%)
Query: 145 IPLAIARLDNSAAKHKLAVKPKKQRVSKKH--RRLAQDPQHEQGGLESRPCLDQNGHPGE 202
I L + L + KL + ++ + H + L Q +E ++ E
Sbjct: 301 IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQE 360
Query: 203 DKPTWHEEEP------NPLDSEEERRRQEDYWRELEAKCKRQKA---EAAEKRRLE---- 249
+K W +EE + EE+ R QE+ RE E K +RQ+ E EK R +
Sbjct: 361 EK-MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM 419
Query: 250 ---EQRLQALERRLWEENRRQELLEEE-------GEGQEPPLEAERAPREEQQRSLEAPG 299
E++++ E +WE+ + LEE+ E +E E E+ +E+++ EA
Sbjct: 420 WEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 479
Query: 300 WEDAER-REREER-----ERLEAEEERRRLQAQAQAEERRRLEEDA-RLEERRRQEEEEG 352
W E+ RE+EE+ E++ +EE+ Q + + EE+R+ +E+ R EE+ R++EE
Sbjct: 480 WRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIW 539
Query: 353 RCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHL 412
R E++ QEE+ + E++ +QE ++ E + E E + +EE + E+EE+ +
Sbjct: 540 RQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQ-EEKVWRQEEKIREQEEKIREQE 598
Query: 413 EDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQ 472
E R Q E+ + EE++ +QE E + + E+ E+ + E+ REQ+ + + +
Sbjct: 599 EKIREQ-EEMTQEQEEKMGEQEEKMCEQEEKMQEQE---EKMRRQEEKIREQEKKIREQE 654
Query: 473 GADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRW-QEVDERQ 531
R E +E+ E + +QE + + ++ +E E+ R+ EE W QEV RQ
Sbjct: 655 EKIREQEEMMQEQ--EEKMWEQEEKMCEQEEKMQEQE----EKMRRQEEKMWEQEVRLRQ 708
Score = 97.8 bits (242), Expect = 6e-20
Identities = 95/349 (27%), Positives = 163/349 (46%), Gaps = 50/349 (14%)
Query: 202 EDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLW 261
E + E+E + EE+ RRQE+ E E K +RQ+ EK E++++ E +W
Sbjct: 379 EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK----EEKMRRQEEMMW 434
Query: 262 EENRRQELLEEE-------GEGQEPPLEAERAPREEQQRSLEAPGWEDAER-REREER-- 311
E+ + LEE+ E +E E E+ +E+++ EA W E+ RE+EE+
Sbjct: 435 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 494
Query: 312 ---ERLEAEEERRRLQAQAQAEERRRLEEDA-RLEERRRQEEEEGRCAEELKRQEE---- 363
E++ +EE+ Q + + EE+R+ +E+ R EE+ R++EE R E++ QEE
Sbjct: 495 EQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRK 554
Query: 364 EEAEGW----------EELEQQEAEVQGPPEALEETGEGRRGAEE-------------ED 400
+E + W E++ +QE +V E + E E R EE E
Sbjct: 555 QEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEK 614
Query: 401 LGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNP---E 457
+GE+EE+ E+ + E + EE++ +QE+ E + + E+ + +EQ E
Sbjct: 615 MGEQEEK-MCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 673
Query: 458 AERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVE 506
E + +Q Q EEK E + L +QE ++ Q +E
Sbjct: 674 QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVR-LRQQEEKMQEHQEHLE 721
Score = 76.3 bits (186), Expect = 2e-13
Identities = 55/213 (25%), Positives = 111/213 (52%), Gaps = 15/213 (7%)
Query: 202 EDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEA---AEKRRLEEQRLQALER 258
E + W +EE + +EE RQ++ E E K ++Q+ + EK +E++++ E
Sbjct: 521 EQEEMWRQEEK--IREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEE 578
Query: 259 RLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEE 318
++W + + EE+ QE + + +EQ+ + + E + E+ E+++ +E
Sbjct: 579 KVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMG-----EQEEKMCEQEEKMQEQE 633
Query: 319 ERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEE-LKRQEEEEAEGWEELEQQEA 377
E+ R Q + E+ +++ E EE+ R++EE + EE + QEE+ E E++++QE
Sbjct: 634 EKMRRQEEKIREQEKKIREQ---EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 690
Query: 378 EVQGPPEALEETGEGRRGAEEEDLGEEEEEGQA 410
+++ E + E E R +EE + E +E +A
Sbjct: 691 KMRRQEEKMWEQ-EVRLRQQEEKMQEHQEHLEA 722
Score = 66.2 bits (160), Expect = 2e-10
Identities = 75/310 (24%), Positives = 143/310 (46%), Gaps = 33/310 (10%)
Query: 232 EAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQ 291
+ + K + A+ EK +L E ++ + E R+ E + Q+ EA+ +E Q
Sbjct: 277 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 336
Query: 292 QRSLEAPGWEDAERREREERERLEAEEE----RRRLQAQAQAEERRRLEEDARLEERRRQ 347
S + A+ E E RL ++E R+ + Q E+ + EE R +E + +
Sbjct: 337 SVSAKL----QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 392
Query: 348 EEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEE 407
E+E E+++RQEE E E++ +QE E + E E R +E++ E+EE
Sbjct: 393 EQE-----EKMRRQEEMMWEKEEKMRRQE-------EMMWEKEEKMR--RQEEMMWEKEE 438
Query: 408 GQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSE------EPGICEEQNPEAERR 461
LE+ + E + + EE+ +++E+++ + +R+ E E I E++ E+
Sbjct: 439 KIRELEE-KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 497
Query: 462 REQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEA--AALEQGRKV 519
+ + ++ EEKR+E E + +QE + + +KE E+ RK
Sbjct: 498 EKMWRQEEKIHEQEKIREEEKRQE--QEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQ 555
Query: 520 EELRWQEVDE 529
EE W++ ++
Sbjct: 556 EEKMWRQEEK 565
Score = 58.2 bits (139), Expect = 5e-08
Identities = 87/366 (23%), Positives = 147/366 (40%), Gaps = 64/366 (17%)
Query: 216 DSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGE 275
+ + + QE RELEA+ + +K L+ + E ++L+ +
Sbjct: 171 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 230
Query: 276 GQEPPLEAERAPREEQQRSLEAPGWEDAERRERE---ERERLEAEEERRRLQAQAQAEER 332
+ E E+A S A + A+R E ER+ L E R + + E+
Sbjct: 231 SWKFAGELEQA------LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKN 284
Query: 333 RRLEEDARLEERRRQEEEEGRCAEELKRQEE----------------------------- 363
+L+E +L E + E + +ELKR+ E
Sbjct: 285 AKLQEKLQLVESEKSEIQLN--VKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKL 342
Query: 364 ----EEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQL 419
EE E W L QQ+ E E + E + +EE + E+EE+ + E R Q
Sbjct: 343 QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ- 401
Query: 420 SELLNDFEERLEDQERL---KPEGQR-------EHSEEPGICEEQNPEAERRREQQGRSG 469
E++ + EE++ QE + K E R E E+ EE+ E E+ REQ+ +
Sbjct: 402 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKR- 460
Query: 470 DFQGADRPGPEEKREEGDT------EPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELR 523
Q ++ +EKR+E + E + +QE + + + R+E EQ + EE +
Sbjct: 461 --QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEK 518
Query: 524 WQEVDE 529
QE +E
Sbjct: 519 RQEQEE 524
Score = 54.7 bits (130), Expect = 5e-07
Identities = 47/197 (23%), Positives = 92/197 (46%), Gaps = 23/197 (11%)
Query: 158 KHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDS 217
K K+ + +K R ++ ++ H+Q +Q + E+E +
Sbjct: 542 KEKIHEQEEKIRKQEEKMWRQEEKMHDQ----EEKIREQEEKVWRQEEKIREQEEKIREQ 597
Query: 218 EEERRRQEDYWRELEAKCKRQK---AEAAEKRRLEEQRLQALERRLWEENRRQELLEEEG 274
EE+ R QE+ +E E K Q+ E EK + +E++++ E ++ E+ ++ + E+E
Sbjct: 598 EEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKK--IREQEE 655
Query: 275 EGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRR 334
+ +E +EE + E WE E + E+ E+++ +EE+ R Q + E+ R
Sbjct: 656 KIRE---------QEEMMQEQEEKMWEQ-EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVR 705
Query: 335 LEEDARLEERRRQEEEE 351
L R +E + QE +E
Sbjct: 706 L----RQQEEKMQEHQE 718
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 107 bits (266), Expect = 9e-23
Identities = 104/423 (24%), Positives = 185/423 (43%), Gaps = 37/423 (8%)
Query: 164 KPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPT-WHEEEPNPLDSEEERR 222
K ++++ ++ R + ++ Q E ++ G G D+ T E D+E+ER
Sbjct: 103 KERERQTDRERDRQREKERNRQKERERET--EREGERGRDRQTDGQRERERQRDAEKERE 160
Query: 223 RQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLE 282
RQ D R+ + + RQK EK R E + ER+ +EN+ ++ E G +E E
Sbjct: 161 RQTDRERQRQTERNRQKEREREKNRQERRER---ERQREKENKTEDRHSERGRERERERE 217
Query: 283 AERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLE 342
E ++Q E +R+ + ERER + E R + + + ++ R E D +
Sbjct: 218 TETETERKRQTDRER------DRQRKTEREREKQAERERASERETERDKERERERDRDRD 271
Query: 343 ERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLG 402
RRQ+E E + + +R+ E + E + E+Q + + E R E E
Sbjct: 272 RDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQR 331
Query: 403 EEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKP---EGQREHSEEPGICEEQNPEAE 459
E E + + E R + +E+ D+ER + EG+R+ E E++ ++
Sbjct: 332 ETERDREKERERKRKRQTEM---------DRERNRQTGREGRRQAERERERERERDRQSA 382
Query: 460 RRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKV 519
R RE++ R D DR E++ E D + + E E + +R+ E+GR+
Sbjct: 383 REREERERDRD---RDRQKERERQTEKDRDGQRETEKQREREK---DRESERGRERGRER 436
Query: 520 EELRWQEVD-ERQT------MPRPYTFQVSSGGKQILFPKVNLSPVTPAKDTGLTAAPQE 572
E+ + +E D ERQT + T V+ + V P P + ++P++
Sbjct: 437 EKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPED 496
Query: 573 PKA 575
PKA
Sbjct: 497 PKA 499
Score = 84.7 bits (208), Expect = 5e-16
Identities = 92/369 (24%), Positives = 151/369 (40%), Gaps = 23/369 (6%)
Query: 171 SKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRE 230
S + R L Q + G R + E + T E D + ERRR++D R+
Sbjct: 36 SPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERET-----DRKRERRREKDRHRK 90
Query: 231 LEAKCKRQKAEAAEK-RRLEEQRLQALERRLWEENRRQELLEEEGE--------GQEPPL 281
+ +RQ+ E+ R+ + +R + E+ + R+ E EGE GQ
Sbjct: 91 RDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRER- 149
Query: 282 EAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARL 341
E +R +E++R + ER ++ERER + +ERR + Q + E + R
Sbjct: 150 ERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERG 209
Query: 342 EERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDL 401
ER R+ E E E KRQ + E + + E+ E E Q E E R E +
Sbjct: 210 RERERERETETET--ERKRQTDRERDRQRKTER-EREKQAERERASERETERDKERERER 266
Query: 402 GEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERR 461
+ + + E R + E E + + + + +RE E E+ E ER
Sbjct: 267 DRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERE 326
Query: 462 REQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEE 521
RE+Q + + +R +++ E D E +Q G Q ER+ E+ R +
Sbjct: 327 RERQRETERDREKERERKRKRQTEMDRE-RNRQTGREGRRQAERERER----ERERDRQS 381
Query: 522 LRWQEVDER 530
R +E ER
Sbjct: 382 AREREERER 390
Score = 76.6 bits (187), Expect = 1e-13
Identities = 82/319 (25%), Positives = 132/319 (41%), Gaps = 31/319 (9%)
Query: 218 EEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQ 277
+ ER RQ++ R E + ++ + +RR E+ R + +R + R++
Sbjct: 53 DRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREK--------- 103
Query: 278 EPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEE 337
E ER E+ R E ER ++ERER E R Q + R +
Sbjct: 104 ----ERERQTDRERDRQREK------ERNRQKERERETEREGERGRDRQTDGQRERERQR 153
Query: 338 DARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAE 397
DA +ER RQ + E + E RQ+E E E E++E E Q E E RG E
Sbjct: 154 DAE-KERERQTDRERQRQTERNRQKEREREK-NRQERRERERQREKENKTEDRHSERGRE 211
Query: 398 EEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPE 457
E E E E + R + ++ D + + E + + E +R E +E+ E
Sbjct: 212 RERERETETETE------RKRQTDRERDRQRKTEREREKQAERERASERETERDKERERE 265
Query: 458 AERRREQQGRSGDFQ-GADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQG 516
+R R++ R + + DR ++R E D E K+E E + ER E+
Sbjct: 266 RDRDRDRDRRQKERERQTDR--KRQRRTERDRETERKRERQRERERER-ERNRKRERERE 322
Query: 517 RKVEELRWQEVDERQTMPR 535
R+ E R +E + + R
Sbjct: 323 RERERERQRETERDREKER 341
Score = 68.9 bits (167), Expect = 3e-11
Identities = 73/262 (27%), Positives = 115/262 (43%), Gaps = 28/262 (10%)
Query: 294 SLEAPGWEDAERR----------EREERER-LEAEEERRRLQAQAQAE-----------E 331
S PG +++ RR + ++RER + E ERRR + Q + E +
Sbjct: 27 SRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKD 86
Query: 332 RRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGE 391
R R + R +R R++E E + E RQ E+E +E E +E E +G +T +
Sbjct: 87 RHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERE-RETEREGERGRDRQT-D 144
Query: 392 GRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQRE-HSEEPGI 450
G+R E + E+E E Q E R + E QER + E QRE ++
Sbjct: 145 GQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDR 204
Query: 451 CEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEA 510
E+ E ER RE + + + DR +++ E + E KQ A++ ER +
Sbjct: 205 HSERGRERERERETETETERKRQTDRERDRQRKTERERE---KQAERERASERETERDKE 261
Query: 511 AALEQGRKVEELRWQEVDERQT 532
E+ R + R Q+ ERQT
Sbjct: 262 RERERDRDRDRDRRQKERERQT 283
Score = 35.0 bits (79), Expect = 0.44
Identities = 32/135 (23%), Positives = 52/135 (38%), Gaps = 8/135 (5%)
Query: 987 ELLSRRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLP 1046
E S R D E D++ DRR +RK Q+R E + TERK
Sbjct: 249 ERASERETERDKERERERDRDRDR-DRRQKERERQTDRKRQRRTERDRETERK------- 300
Query: 1047 ATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQKGFREQQAT 1106
+Q + + E RK + + + + TE+ + + R +Q
Sbjct: 301 RERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTG 360
Query: 1107 REERKQAREAKQAEK 1121
RE R+QA ++ E+
Sbjct: 361 REGRRQAERERERER 375
Score = 34.3 bits (77), Expect = 0.75
Identities = 37/170 (21%), Positives = 71/170 (41%), Gaps = 8/170 (4%)
Query: 991 RRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQ 1050
R R + E ++ Q DR G E R+ +R+ E E + + A ++
Sbjct: 331 RETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQS-----ARER 385
Query: 1051 EKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQKGFREQQATRE-- 1108
E+ + + R+++ Q+ DG + TEK + + +++ RE+Q RE
Sbjct: 386 EERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERD 445
Query: 1109 -ERKQAREAKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPE 1157
ER+ R+A + K S V+ + S V ++ + + + PE
Sbjct: 446 RERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPE 495
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 107 bits (266), Expect = 9e-23
Identities = 90/334 (26%), Positives = 169/334 (50%), Gaps = 34/334 (10%)
Query: 215 LDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEG 274
L ++ + + +EL++ + +A+ E+ L + Q E ++W + + + EE+
Sbjct: 246 LPQQQLQAEADHLGKELQSVSAKLQAQV-EENELWNRLNQQQEEKMWRQEEKIQEREEKI 304
Query: 275 EGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRR 334
+ QE + + EE+ R E WE E+ R+E E EE+ R L EE+
Sbjct: 305 QEQEEKIREQ----EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL------EEKMH 354
Query: 335 LEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGW---EELEQQEAEVQGPPEALEETGE 391
+E R +E +RQEEE+ R E ++++E+EA+ W E++ +QE +++ E ++E E
Sbjct: 355 EQEKIREQEEKRQEEEKIR---EQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQ-E 410
Query: 392 GRRGAEEEDLGEEEEEGQAHLEDWRGQLSEL------LNDFEERLEDQERLKPEGQREHS 445
+ G +EE + E+EEE Q E R Q ++ + + EE++ +QE + E + +
Sbjct: 411 EKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMG 470
Query: 446 EEPG-ICEEQ---NPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAA 501
E+ G +CE++ + E+ R Q+ + + + R E+ RE+ E + +QE +
Sbjct: 471 EQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ--EEMMQEQEEKMWEQ 528
Query: 502 QPPVERKEAAALEQGRKV----EELRWQEVDERQ 531
+ + +E EQ K+ E++R QEV RQ
Sbjct: 529 EEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQ 562
Score = 102 bits (255), Expect = 2e-21
Identities = 92/354 (25%), Positives = 168/354 (47%), Gaps = 25/354 (7%)
Query: 145 IPLAIARLDNSAAKHKLAVKPKKQRVSKKH--RRLAQDPQHEQGGLESRPCLDQNGHPGE 202
I L + L + KL + ++ + H + L Q +E ++ E
Sbjct: 228 IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQE 287
Query: 203 DKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWE 262
+K W +EE + EE+ + QE+ RE E K +RQ+ EK E++++ E +WE
Sbjct: 288 EK-MWRQEEKIQ-EREEKIQEQEEKIREQEEKMRRQEEMMWEK----EEKMRRQEEMMWE 341
Query: 263 ENRRQELLEEE-------GEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLE 315
+ + LEE+ E +E E E+ +E+++ EA W E + RE+ E++
Sbjct: 342 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ-EEKIREQEEKIR 400
Query: 316 AEEERRRLQAQAQAEERRRL----EEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEE 371
+EE + Q + E+ ++ EE EE+ R++EE+ R E+ R++EE+ EE
Sbjct: 401 EQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 460
Query: 372 LEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLE 431
+ Q++ E G E E + +EE + +EE+ + + R Q E + + EE ++
Sbjct: 461 MMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQ-EEKIREQEEMMQ 519
Query: 432 DQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREE 485
+QE E + + E+ +EQ E RR+E++ R + + + EEK +E
Sbjct: 520 EQEEKMWEQEEKMCEQEEKMQEQE-EKMRRQEEKMREQEVRLRQQ---EEKMQE 569
Score = 96.3 bits (238), Expect = 2e-19
Identities = 91/327 (27%), Positives = 161/327 (49%), Gaps = 41/327 (12%)
Query: 211 EPNPLDSEEERRRQEDYWRELEAKCKRQKA--EAAEKRRLEEQRLQALERRLWEEN---R 265
E N L + ++++E WR+ E +R++ E EK R +E++++ E +WE+ R
Sbjct: 274 EENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMR 333
Query: 266 RQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQA 325
RQE + E E + LE E+ +E+ R E E+ + RE+E+R+ EA+ R
Sbjct: 334 RQEEMMWEKEEKIRELE-EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR----- 387
Query: 326 QAQAEERRRLEEDARLEERRRQEEEE--GRCAEELKRQEEEEAEGWEELEQQEAEVQGPP 383
Q E+ R EE R +E QE+EE G E++ QEEE E E++ +QE +++
Sbjct: 388 --QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQE 445
Query: 384 EALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQRE 443
+ + E E R E+E++ +E+EE E + + + EE++ QE E +++
Sbjct: 446 KKIREQEEKIR--EQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKK 503
Query: 444 HSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQP 503
E+ EE+ E E ++Q EEK E + E + +QE ++ +
Sbjct: 504 IREQ----EEKIREQEEMMQEQ--------------EEKMWEQE-EKMCEQEEKMQEQEE 544
Query: 504 PVERKEAAALEQGRKVEELRWQEVDER 530
+ R+E EQ E+R ++ +E+
Sbjct: 545 KMRRQEEKMREQ-----EVRLRQQEEK 566
Score = 82.4 bits (202), Expect = 2e-15
Identities = 63/211 (29%), Positives = 112/211 (53%), Gaps = 25/211 (11%)
Query: 218 EEERRRQEDYWRELEAKCKRQKA---EAAEKRRLEEQRLQALERRLWEENRRQELLEEEG 274
EEE+ R+++ +E EAK RQ+ E EK R +E+ +Q E ++ E+ + EEE
Sbjct: 368 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEM 427
Query: 275 EGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEER----------RRLQ 324
+ QE + + EQ++ + + E + RE+ E ++ +EE+ + +
Sbjct: 428 QEQEEKMRRQEEKIREQEKKIR-----EQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAK 482
Query: 325 AQAQAEERRRLEEDARLEERR-RQEEEEGRCAEELKRQEEEEAEGWEELE---QQEAEVQ 380
Q Q E+ RR EE R +E++ R++EE+ R EE+ +++EE+ WE+ E +QE ++Q
Sbjct: 483 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM--WEQEEKMCEQEEKMQ 540
Query: 381 GPPEALEETGEGRRGAEEEDLGEEEEEGQAH 411
E + E R +E L ++EE+ Q H
Sbjct: 541 EQEEKMRRQEEKMR-EQEVRLRQQEEKMQEH 570
Score = 63.9 bits (154), Expect = 9e-10
Identities = 81/343 (23%), Positives = 149/343 (43%), Gaps = 39/343 (11%)
Query: 216 DSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGE 275
+ + + QE RELEA+ + + +K L+ + E ++L+ +
Sbjct: 98 EQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 157
Query: 276 GQEPPLEAERAPREEQQRSLEAPGWEDAERRERE---ERERLEAEEERRRLQAQAQAEER 332
+ E E+A S A + A+R E ER+ L E R + + E+
Sbjct: 158 SWKFAGELEQA------LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKN 211
Query: 333 RRLEEDARLEERRRQEEEEGRCAEELKR----------QEEEEAEG---WEELEQQEAEV 379
+L+E +L E + E + +ELKR Q++ +AE +EL+ A++
Sbjct: 212 AKLQEKLQLVESEKSEIQLN--VKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKL 269
Query: 380 QGPPE------ALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQ 433
Q E L + E + +EE + E EE+ Q E R Q ++ E E +
Sbjct: 270 QAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKE 329
Query: 434 ERLKPEGQREHSEEPGI--CEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPL 491
E+++ + + +E I EE+ E E+ REQ+ + Q ++ +EKR+E + + +
Sbjct: 330 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKR---QEEEKIREQEKRQEQEAK-M 385
Query: 492 LKQEGPVEAAQPPVERKEAAALEQGRKV---EELRWQEVDERQ 531
+QE + + + +E EQ K+ EE W++ +E Q
Sbjct: 386 WRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQ 428
Score = 35.0 bits (79), Expect = 0.44
Identities = 37/176 (21%), Positives = 77/176 (43%), Gaps = 16/176 (9%)
Query: 999 EPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPE 1058
E E +E +E + E+R+ +++ E+E + + A Q+EK + E
Sbjct: 341 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM---WRQEEKIREQEE 397
Query: 1059 AGRKEKPMLQSRHSLDGS---KLTEKVETAQPLWITLALQKQKGFREQQATREERKQARE 1115
R+++ M+Q + G K+ E+ E Q Q++K R+++ RE+ K+
Sbjct: 398 KIREQEEMMQEQEEKMGEQEEKMWEQEEEMQE-------QEEKMRRQEEKIREQEKK--- 447
Query: 1116 AKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPETAVSRLERREQLKK 1171
++ E+ +E + + + G + + A +E+ + + REQ KK
Sbjct: 448 IREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKK 503
>gi|116256464 hypothetical protein LOC343990 [Homo sapiens]
Length = 962
Score = 96.7 bits (239), Expect = 1e-19
Identities = 188/783 (24%), Positives = 274/783 (34%), Gaps = 126/783 (16%)
Query: 1 MGTRAFSHDSIFIPDGGAESEQTVQAMSQDNILGKVKTLQQQLGKNIKFG-QRSPNAIPM 59
+G+RA SHDSIFIP+ G ++ + V+ SQ+N+ ++K LQ ++ N+K G P +P
Sbjct: 86 LGSRALSHDSIFIPESGQDATRPVRVFSQENVCDRIKALQLKIQCNVKMGPPPPPGGLPA 145
Query: 60 NKANSGEASLEEDLFLTSPMEIVTQQDIVLSDAENKSSDTPSSLSPLNLPGAGSEMEEKV 119
+ S E+D SP E+ D+ S +P +S + S + +
Sbjct: 146 KRGEDAGMSSEDDGLPRSPPEMSLLHDVGPGTTIKVSVVSPDHVSDSTVSARIS--DNSL 203
Query: 120 APVKPSRPKRHFSSAGTIESVNLDAIPLAIARLDNSAAKHKLAVKPKKQRVSKKHRRLAQ 179
APV SS LDNSAAKHKL VKP+ QR S K RRL+
Sbjct: 204 APVADFSYPAESSSC-----------------LDNSAAKHKLQVKPRNQR-SSKMRRLSS 245
Query: 180 DPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQK 239
Q E L C + E+KP E P S ++ D E
Sbjct: 246 RAQSE--SLSDLTCTPEE-EENEEKPLL-EVSPEERPSSGQQDVAPDRGPEPGPPAPLPP 301
Query: 240 AEAAEKRRLEEQRLQALERRLWE----------ENRRQELLEEEGEGQ---EPPLEAERA 286
A RR Q AL + E EL E E EPP E
Sbjct: 302 PGGARARRARLQHSSALTASVEEGGVPGEDPSSRPATPELAEPESAPTLRVEPPSPPEGP 361
Query: 287 PRE----EQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLE 342
P +Q P A ++ E E+ + E D
Sbjct: 362 PNPGPDGGKQDGEAPPAGPCAPATDKAEEVVCAPEDVASPFPTAIPEGDTTPPETDP--- 418
Query: 343 ERRRQEEEEGRCAEELKRQEEEEAEGWEE-LEQQEAEVQGP---PEALEETGEGR-RGAE 397
E + +R +EAE L +E GP PE ET R G E
Sbjct: 419 ---AATSEAPSARDGPERSVPKEAEPTPPVLPDEEKGPPGPAPEPEREAETEPERGAGTE 475
Query: 398 EEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREH---SEEPGICEEQ 454
E +G E A S L + E P E PG + +
Sbjct: 476 PERIGTEPSTAPAPSPP--APKSCLKHRPAAASEGPAASPPLAAAESPPVEPGPGSLDAE 533
Query: 455 NPEAERRREQQGRSGDFQGADRPGPEEKREEGDTE----------------------PLL 492
ER + ++ + GA+R PE K E G E PL
Sbjct: 534 AAAPERPKAERAEAPP-AGAERAAPERKAERGGAELRGAKKFSVSSCRARPRPGVSRPLE 592
Query: 493 KQEGPVEAAQP-PVERKEAAALEQGRKVEELRWQEVDERQTMPRPYTFQVSSGGKQILFP 551
+ G + A+ PV R EAA +D+ Q +P P G +++
Sbjct: 593 RASGRLPLARSGPVWRSEAA---------------LDDLQGLPEPQ--HAKPGPRKLAER 635
Query: 552 KVNLSPVTPAKDTGLTAAPQE-----------PKAPKASPVQHALPSSLSVPHTAILV-- 598
S A G +PQE P A + +P + P + + T++ +
Sbjct: 636 GPQDSGDRAASPAGPRKSPQEAAAAPGTREPCPAAQEPAPSEDRNPFPVKLRSTSLSLKY 695
Query: 599 ---TGAQLCGPAVNLSQIKDTACKSLLGLEEKKHAEAPAGENP----PRGPGDARAGSGK 651
++ G ++++ ++L EEK P G P R P D G GK
Sbjct: 696 RDGASQEVKGVKRYSAEVRLERSLTVLPKEEK----CPLGTAPALRGTRAPSD--QGKGK 749
Query: 652 AKPRQESPSSASALAEWASIRSRILKNAESDPRSSERDQLRPGDESTPRGRCDSRGNQRK 711
A+P E SS L ++S L + + P + ++ + T R RG ++
Sbjct: 750 ARP-PEPLSSKPPLPRKPLLQSFTLPHQPAPPDAGPGEREPRKEPRTAEKRPLRRGAEKS 808
Query: 712 TPP 714
PP
Sbjct: 809 LPP 811
Score = 83.2 bits (204), Expect = 1e-15
Identities = 151/637 (23%), Positives = 238/637 (37%), Gaps = 85/637 (13%)
Query: 635 GENPPRGPGDARAGSGKAKPRQESPSSASALAEWASIRSRILKNAESDPRS-SERDQLRP 693
GE PP GP + KA+ +P ++ A I E+DP + SE R
Sbjct: 373 GEAPPAGP--CAPATDKAEEVVCAPEDVASPFPTA-IPEGDTTPPETDPAATSEAPSARD 429
Query: 694 GDE-STPRGRCDSRGNQRKTPPVNAKFSIMPAWQKFSDGGTETSKQSTEAESIR----KR 748
G E S P+ TPPV +P +K G ++ E E R +
Sbjct: 430 GPERSVPK-------EAEPTPPV------LPDEEKGPPGPAPEPEREAETEPERGAGTEP 476
Query: 749 PMLGPSEETAPQPPPAGVRELGKGPEKSEMHREPADTTEGCKFAKDLPSFLVPSLPYPPQ 808
+G TAP P P KS + PA +EG + L + P + P
Sbjct: 477 ERIGTEPSTAPAPSPPA--------PKSCLKHRPAAASEGPAASPPLAAAESPPVEPGPG 528
Query: 809 KVVAHTEFTTSSDSETANGIAKPDPVMPGGEEKASPF------GIKLRRTNYSLRFNCDQ 862
+ A +E A P G E+A+P G +LR +C
Sbjct: 529 SLDAEAAAPERPKAERAEA-------PPAGAERAAPERKAERGGAELRGAKKFSVSSCRA 581
Query: 863 QAE---QKKKKRHSSTGDSADAGPPAAGSARGEKEMEGVA----LKHGPSLPQERKQAPS 915
+ + +R S A +GP A + +++G+ K GP ER S
Sbjct: 582 RPRPGVSRPLERASGRLPLARSGPVWRSEAALD-DLQGLPEPQHAKPGPRKLAERGPQDS 640
Query: 916 TRRDSAEPSSSRSVP---VAHPGP--PPASSQTPAPEHDKAANKMPLAQKPALAPKPTSQ 970
R +A P+ R P A PG P ++Q PAP D+ P K
Sbjct: 641 GDR-AASPAGPRKSPQEAAAAPGTREPCPAAQEPAPSEDRN----PFPVKLRSTSLSLKY 695
Query: 971 TPPASPLSKLSRPYLVELLSRRAGRPDPEPSE------------PSKEDQESSDRRPPSP 1018
AS K + Y E+ R+ P+ + + DQ RPP P
Sbjct: 696 RDGASQEVKGVKRYSAEVRLERSLTVLPKEEKCPLGTAPALRGTRAPSDQGKGKARPPEP 755
Query: 1019 PGPEERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKL 1078
+ +K + +PA PP + +P + P K + SL +
Sbjct: 756 LSSKPPLPRKPLLQSFTLPHQPA-PPDAGPGEREPRKEPRTAEKRPLRRGAEKSLPPAAT 814
Query: 1079 TEKVE-TAQPLWITLALQKQKGFREQQATREERKQAREAKQAEKLSKENVSVSV-QPGSS 1136
+ P WIT+ QK++G +Q +E++ AR K S+ V + G
Sbjct: 815 GPGADGQPAPPWITVTRQKRRGTLDQPPNQEDKPGARTLK-----SEPGKQAKVPERGQE 869
Query: 1137 SVSRAGSLHKSTALPEEKRPETAVSRLERREQLKKANTLPTSVTVEISDSAPPAPLVKEV 1196
V +A + + L +P AV R ++ +L L +++ + A A ++++
Sbjct: 870 PVKQADFVRSKSFLITPVKP--AVDR-KQGAKLNFKEGLQRGISLSHQNLAQSAVMMEKE 926
Query: 1197 TKRFSTPDAAPVSTEPAWLALAKRKAKAWSDCPQIIK 1233
+ A +P+W+ LA++K++AWSD PQIIK
Sbjct: 927 LHQLKRASYASTD-QPSWMELARKKSQAWSDMPQIIK 962
Score = 34.7 bits (78), Expect = 0.58
Identities = 43/193 (22%), Positives = 70/193 (36%), Gaps = 21/193 (10%)
Query: 873 SSTGDSADAGPPAAGSARGEKEMEGVALKHGPSLPQERKQAPSTRRDSAEPSSSRSVPVA 932
+S AD PA S+ ++ A KH + +++ RR S+ S +
Sbjct: 201 NSLAPVADFSYPAESSSC----LDNSAAKHKLQVKPRNQRSSKMRRLSSRAQSESLSDLT 256
Query: 933 HPGPPPASSQTP----APEHDKAANKMPLAQKPALAPKPTSQTPPASPL----SKLSRPY 984
+ + P +PE ++ + +A P P + PP ++L
Sbjct: 257 CTPEEEENEEKPLLEVSPEERPSSGQQDVAPDRGPEPGPPAPLPPPGGARARRARLQHSS 316
Query: 985 LVELLSRRAGRPDPEPSE----PSKEDQESSDR---RPPSPPGPEERKGQKRDEEEEATE 1037
+ G P +PS P + ES+ PPSPP G D ++ E
Sbjct: 317 ALTASVEEGGVPGEDPSSRPATPELAEPESAPTLRVEPPSPPEGPPNPGP--DGGKQDGE 374
Query: 1038 RKPASPPLPATQQ 1050
PA P PAT +
Sbjct: 375 APPAGPCAPATDK 387
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 94.0 bits (232), Expect = 8e-19
Identities = 96/410 (23%), Positives = 174/410 (42%), Gaps = 37/410 (9%)
Query: 205 PTWHEEEPNPLDSEEERR----RQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRL 260
P +E+ N ++ EE++R R+ +R+ K + +K + EK R E ++ ERR
Sbjct: 257 PLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKK-EKERQEIEK----ERR- 310
Query: 261 WEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERER-LEAEEE 319
E R+ E E +E E ER +E++R E D +R + +R+R E + +
Sbjct: 311 --ERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRD 368
Query: 320 RRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELE-QQEAE 378
R R ++ + ++R R E +R ER R+ E E E +R+ E E E E E ++E +
Sbjct: 369 RDRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKD 428
Query: 379 VQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKP 438
+ E EE RR E + L E+E Q L++W + + ++E+ E +E +
Sbjct: 429 KKRDREEDEEDAYERRKLERK-LREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRR 487
Query: 439 EGQREHSEEPGICEEQNPEAERRREQQG---------RSGDFQGADRPGPEEKREEGDTE 489
E +E E+ + + + + +G R + + +R EK E +
Sbjct: 488 EMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIR 547
Query: 490 PLLKQEG------PVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQTMPRPYTFQVSS 543
L EG ++ + ER+ ++Q + EE ++ ++ + P +
Sbjct: 548 QRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEP 607
Query: 544 GGKQILFPKVNLSPVTPAKDTGLTAAPQEPKAPKASPVQHALPSSLSVPH 593
K L P L P++ A + P P P + +PH
Sbjct: 608 EQKPCLKP--TLRPISSAPSVSSASGNATPNTPGDES-----PCGIIIPH 650
Score = 84.0 bits (206), Expect = 8e-16
Identities = 100/403 (24%), Positives = 169/403 (41%), Gaps = 44/403 (10%)
Query: 209 EEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALER-RLWEENRRQ 267
EEE + E + +E RE E + +R++ E +R E +R + ER R E +R +
Sbjct: 292 EEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDR 351
Query: 268 ELLEEEGEGQEPPLEAERAPR------EEQQRSLEAPGWEDAERREREERERLEAEEERR 321
+ +E ++ + +R +++ RS E + ER ERER ER
Sbjct: 352 DRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERER-----ERE 406
Query: 322 RLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQG 381
R + + + ER R E R ++++R EE+ A E ++ E +L ++EA Q
Sbjct: 407 REREREREREREREREREREKDKKRDREEDEEDAYERRKLE-------RKLREKEAAYQ- 458
Query: 382 PPEALE--ETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLED------- 432
E L+ E E ++ E E E EEE + + +L E L D+++ +D
Sbjct: 459 --ERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGS 516
Query: 433 --QERLKP-EGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTE 489
Q+RL+ E + E E E++ E R+R +G P E +R E + E
Sbjct: 517 ALQKRLRDREKEMEADERDRKREKEELEEIRQRLLA------EGHPDPDAELQRMEQEAE 570
Query: 490 PLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQTMPRPYTFQVSSGGKQIL 549
++ P +P E +E E+ K EE +E + Q T + S +
Sbjct: 571 ---RRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVS 627
Query: 550 FPKVNLSPVTPAKDTGL-TAAPQEPKAPKASPVQHALPSSLSV 591
N +P TP ++ P E + P +H LS+
Sbjct: 628 SASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSL 670
Score = 36.6 bits (83), Expect = 0.15
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 12/67 (17%)
Query: 994 GRPDPEPSEPSKEDQESSDRRPPS---PPGPEERKGQKRDEEEEATERKPASPPLPATQQ 1050
G PDP+ +E + +QE+ RR P P EE + +K+++EE+ E P ++
Sbjct: 554 GHPDPD-AELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREE--------PMEEE 604
Query: 1051 EKPSQTP 1057
E+P Q P
Sbjct: 605 EEPEQKP 611
Score = 34.3 bits (77), Expect = 0.75
Identities = 51/246 (20%), Positives = 93/246 (37%), Gaps = 36/246 (14%)
Query: 991 RRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRD---EEEEATERKPASPPL-- 1045
R R E +E + +R E K +KRD +EE+A ER+ L
Sbjct: 393 REREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLRE 452
Query: 1046 -PATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITL------------ 1092
A QE+ RK+ + + + E + A+ L L
Sbjct: 453 KEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKY 512
Query: 1093 ----ALQKQKGFREQQATREERKQAREAKQAEKLSKENVSVSVQPGSSSVSRAGSLHKST 1148
ALQK+ RE++ +ER + RE ++ E++ + ++ + + R +
Sbjct: 513 YRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERR 572
Query: 1149 ALPEEKR-PETAVSRLERREQLKKANTLPTSVTVEISDSAPPAPLVKEVTKRFSTPDAAP 1207
P+ K+ PE+ E++E+ +K +E + P +K P P
Sbjct: 573 RQPQIKQEPESEEEEEEKQEKEEKREE-----PMEEEEEPEQKPCLK--------PTLRP 619
Query: 1208 VSTEPA 1213
+S+ P+
Sbjct: 620 ISSAPS 625
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 92.8 bits (229), Expect = 2e-18
Identities = 99/408 (24%), Positives = 178/408 (43%), Gaps = 38/408 (9%)
Query: 144 AIPLAIARLDNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGED 203
++ L R+ N A+++ K +K S++ R ++ + + D + ED
Sbjct: 129 SLSLPSRRMQNDTAENETTEKEEKSE-SRQERYEIEETETVTKSYQKNDWRDAEENKKED 187
Query: 204 KPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAE--------AAEKRRLEEQRLQA 255
K EEE P + E E + + + ++E+ + EE+R Q
Sbjct: 188 KEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQG 247
Query: 256 LERRLWEENRRQELLEEEGEGQEPPLEAERAPR--EEQQRSL--EAPGWEDAERREREER 311
+ E +E +E E + LEAE R EQ + + E E E+ +ER
Sbjct: 248 SDEISHHEKMEEED-KERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQER 306
Query: 312 ERLEAEE-ERRRLQAQAQAEERRRLEEDAR--LEERRRQEEEEGRCAEELKRQEEEEAEG 368
ER EAEE ER R + + AEER+R++E+ + EER+R +EEE R AEE +R +EEE
Sbjct: 307 ERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA 366
Query: 369 WEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEE 428
EE ++ AE + + E+ + ++ + E + +G+ + G+ E
Sbjct: 367 AEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKW------VNE 420
Query: 429 RLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDT 488
+ +++L+ ++ EE G +A+R + Q+ + P K+EE
Sbjct: 421 KKAQEDKLQTAVLKKQGEEKG----TKVQAKREKLQEDK-----------PTFKKEEIKD 465
Query: 489 EPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQTMPRP 536
E + K + P E + ++RK+ + + E + + T RP
Sbjct: 466 EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRP 513
Score = 89.0 bits (219), Expect = 3e-17
Identities = 97/422 (22%), Positives = 186/422 (44%), Gaps = 34/422 (8%)
Query: 138 ESVNLDAIPLAIARLDNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQN 197
E + L+A +A R D+ + A + +++R ++ R Q+ + + QN
Sbjct: 16 EEMRLEAERIAYQRNDDDEEE---AARERRRRARQERLRQKQEEESLGQVTDQVEVNAQN 72
Query: 198 GHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRR-----LEEQR 252
P E+ T ++ ++E E R E + KR + EA E+++ + +
Sbjct: 73 SVPDEEAKTTTTN--TQVEGDDEAAFLERLARREERRQKRLQ-EALERQKEFDPTITDAS 129
Query: 253 LQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERE 312
L RR+ + E E+E + + E E +S + W DAE ++E++E
Sbjct: 130 LSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKE 189
Query: 313 RLEAEEERRRL------QAQAQAEERRRLEEDARL----------EERRRQEEEEGRCAE 356
+ E EEE+ + Q + EE+ ++ + E +QEEE + ++
Sbjct: 190 KEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSD 249
Query: 357 ELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWR 416
E+ E+ E E E E + A ++ + + ++ A+E E EE+ A + R
Sbjct: 250 EISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERR 309
Query: 417 -GQLSELLNDFEER-LEDQERLKPEGQREHSEEPGICEEQNPEAERR---REQQGRSGDF 471
+ E + + E+R E+++R+K E +R E I EE+ AE R +E++ R+ +
Sbjct: 310 EAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 369
Query: 472 QGADRPGPEEKREEGDTEPLLKQEGPVEAAQ-PPVERKEAAALEQGRKVEELRWQEVDER 530
+ R EEK + + + + E A Q ++ ++ +G+ V E + QE D+
Sbjct: 370 RQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQE-DKL 428
Query: 531 QT 532
QT
Sbjct: 429 QT 430
Score = 74.3 bits (181), Expect = 7e-13
Identities = 89/371 (23%), Positives = 158/371 (42%), Gaps = 59/371 (15%)
Query: 216 DSEEERRRQEDYWRELEA-KCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQEL----- 269
+ E RRQ+ LEA + Q+ + E+ E+R +A + RL ++ + L
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
Query: 270 -LEEEGEGQEPPLEAERAPREEQ-QRSLEAPGWEDAERREREERERLEAEEER------- 320
+E + P EA+ Q + EA E RRE ++RL+ ER
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Query: 321 ----------RRLQAQAQAEERRRLEEDARLEERRRQEEE-----------EGRCAEELK 359
RR+Q E EE + + R + EE + R AEE K
Sbjct: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184
Query: 360 RQEEEEAEGWEE------LEQQEAEV---QGPPEALEET-----GEGRRGAEEEDLGEEE 405
++++E+ E EE + + + EV + E+ EET G+ +EE EE
Sbjct: 185 KEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEER 244
Query: 406 EEGQ---AHLEDWRGQLSELLNDFEERL--EDQERLKPEGQREHSEEPGICEEQNPEAER 460
E+G +H E + E RL E++ER+K E ++ ++E E + A +
Sbjct: 245 EQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQ 304
Query: 461 RREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVE 520
RE++ + + +R EEKR + + + ++E + ++ +E A E+ ++++
Sbjct: 305 ERERR----EAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK 360
Query: 521 ELRWQEVDERQ 531
E + +ERQ
Sbjct: 361 EEEKRAAEERQ 371
Score = 67.4 bits (163), Expect = 8e-11
Identities = 66/327 (20%), Positives = 152/327 (46%), Gaps = 37/327 (11%)
Query: 153 DNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEP 212
+ AA+ + +K +++R +++ +R+ ++ ++ E + ++ E++ EE
Sbjct: 321 EKRAAEERQRIKEEEKRAAEERQRIKEE--EKRAAEERQRIKEEEKRAAEERQRARAEEE 378
Query: 213 NPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQAL---ERRLWEENRRQEL 269
EE++R ++LE K K E K EQ+++ E++ E+ + +
Sbjct: 379 EKAKVEEQKRN-----KQLEEK-KHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAV 432
Query: 270 LEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAE-RREREERERLEAEEERRRLQAQAQ 328
L+++GE + ++A+R +E + + + +D + ++++E +E +++ +R++ + +
Sbjct: 433 LKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVK 492
Query: 329 AEERR------------------RLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWE 370
++ R D + E Q E R E +R+ E E+E +E
Sbjct: 493 SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE 552
Query: 371 ELEQQEAEVQGPPEALEETGEGRRGA-EEEDLGEEEEEGQAHLEDWRGQLSELLNDFEER 429
+L+Q++ E E L++ E RR EEE+ ++EE L + E +E
Sbjct: 553 KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLRE-----EEEKRRLKEE 607
Query: 430 LEDQERLKPEGQREHSEEPGICEEQNP 456
+E + R + +R+ E G+ +++ P
Sbjct: 608 IE-RRRAEAAEKRQKMPEDGLSDDKKP 633
Score = 46.6 bits (109), Expect = 1e-04
Identities = 58/238 (24%), Positives = 101/238 (42%), Gaps = 40/238 (16%)
Query: 301 EDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKR 360
+D ERR R++ E RL+A+ A +R +E+ ERRR+ + E L++
Sbjct: 2 DDFERRRELRRQK----REEMRLEAERIAYQRNDDDEEEAARERRRRARQ-----ERLRQ 52
Query: 361 QEEEEAEGWEELEQQEAEVQG--PPEALEETGEGRR--GAEE----EDLGEEEEEGQAHL 412
++EEE+ G + +Q E Q P E + T + G +E E L EE Q L
Sbjct: 53 KQEEESLG-QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRL 111
Query: 413 EDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRRE--------- 463
+ + E +F+ + D P + ++ E+ ++E R+E
Sbjct: 112 Q----EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET 167
Query: 464 --QQGRSGDFQGADRPGPEEKREEGDTEPLLKQ----EGPVEAAQPPVERKEAAALEQ 515
+ + D++ A+ E+K +E + E K+ E VE VE K + E+
Sbjct: 168 VTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVM---VEEKTTESQEE 222
Score = 39.3 bits (90), Expect = 0.023
Identities = 57/292 (19%), Positives = 112/292 (38%), Gaps = 25/292 (8%)
Query: 861 DQQAEQKKKKRHSSTGDSADAGPPAAGSARGEKEMEGVALKHGPSLPQERKQAPSTRRDS 920
+++ E+++K + S G++ + ++E ++LK+G +E KQ + S
Sbjct: 189 EKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGS 248
Query: 921 AEPSSSRSVPVAHPGPPPASS---QTPAPEHDKAANKMPLAQKPALAPKPTSQTPPASPL 977
E S + A + E KA +A + A
Sbjct: 249 DEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERER 308
Query: 978 SKLSRPYLVELLSRRAGRPDPEPSEPSKEDQESSDR-RPPSPPGPEERKGQKRDEEEEAT 1036
+ + +RA E K E R + EER+ K +E+ A
Sbjct: 309 REAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE 368
Query: 1037 ERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLD-----GSKLTEKVE-------T 1084
ER+ A A ++EK E ++ K + + +H++ G K+ +K+E
Sbjct: 369 ERQRAR----AEEEEKAKV--EEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKK 422
Query: 1085 AQPLWITLALQKQKGFR---EQQATREERKQAREAKQAEKLSKENVSVSVQP 1133
AQ + A+ K++G + QA RE+ ++ + + E++ E + +P
Sbjct: 423 AQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
Score = 33.5 bits (75), Expect = 1.3
Identities = 39/185 (21%), Positives = 73/185 (39%), Gaps = 16/185 (8%)
Query: 988 LLSRRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPA 1047
++S + G+ E + +E ++ SD EE K +R E E A + A
Sbjct: 225 VMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDK--ERAEAERARLEAEERERIKA 282
Query: 1048 TQQEK-PSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQKGFREQQAT 1106
Q +K + +EK Q R + + E ++++ E+Q
Sbjct: 283 EQDKKIADERARIEAEEKAAAQERERREAEERERMRE-----------EEKRAAEERQRI 331
Query: 1107 REERKQAREAKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPETAVSRLERR 1166
+EE K+A E +Q K ++ + Q RA + EE++ + V +R
Sbjct: 332 KEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAK--VEEQKRN 389
Query: 1167 EQLKK 1171
+QL++
Sbjct: 390 KQLEE 394
Score = 32.7 bits (73), Expect = 2.2
Identities = 46/217 (21%), Positives = 82/217 (37%), Gaps = 16/217 (7%)
Query: 992 RAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQE 1051
R R + E +E + + +D R E +K K EEEE E KP + Q E
Sbjct: 156 RQERYEIEETETVTKSYQKNDWRDAE----ENKKEDKEKEEEE--EEKPKRGSIGENQVE 209
Query: 1052 KPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQKGFREQQATREERK 1111
+ +E+ ++ S + S K E + +K E+ R E +
Sbjct: 210 VMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEK-MEEEDKERAEAE 268
Query: 1112 QAR---------EAKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPETAVSR 1162
+AR +A+Q +K++ E + + +++ R + E+ A R
Sbjct: 269 RARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEER 328
Query: 1163 LERREQLKKANTLPTSVTVEISDSAPPAPLVKEVTKR 1199
+E+ K+A + E +A +KE KR
Sbjct: 329 QRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 365
Score = 31.6 bits (70), Expect = 4.9
Identities = 33/158 (20%), Positives = 66/158 (41%), Gaps = 11/158 (6%)
Query: 1002 EPSKEDQESSDRRPPSPPGPEERKGQKRD------EEEEATERKPASPPLPATQQEKPSQ 1055
EP +E + DR+ G E K Q + + E T +P T++ + +
Sbjct: 473 EPKEEVKSFMDRKK----GFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAP 528
Query: 1056 TPEAGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQKGFREQQATREERKQARE 1115
EAG++ + + + R + + + + Q + L K+K E++ EE +Q R+
Sbjct: 529 QVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR-EERRKVLEEEEQRRK 587
Query: 1116 AKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEE 1153
++A++ +E RA + K +PE+
Sbjct: 588 QEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 625
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 92.4 bits (228), Expect = 2e-18
Identities = 220/1113 (19%), Positives = 394/1113 (35%), Gaps = 205/1113 (18%)
Query: 152 LDNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEE 211
+ N+ + ++ +P +V + L P L HP D+
Sbjct: 370 VSNTKSSSQIPAQPSVAKVPYGKGPSFNQERGTSSHLPPPPKLLAQQHPPPDRQAV-PGR 428
Query: 212 PNPLDSEEERRRQEDYWRELEAKCKRQKA--EAAEKRRLEEQRLQALERRLWEENRRQEL 269
P P S+++ +++ W++ + A E A KRR EE+R +R+ + + L
Sbjct: 429 PGPFPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRL 488
Query: 270 LEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQA 329
E+ G LE + +P E ++R E + E + +E+ER + E+ R Q + +
Sbjct: 489 DEKLG-----ILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEK 543
Query: 330 EERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQ-EAEVQGPPEALEE 388
E + E+ +E+ R+QE+E +EL+RQ+E+E E + EQ+ E E++ E LEE
Sbjct: 544 ELEKEQEKQREMEKERKQEKE-----KELERQKEKEKELQKMKEQEKECELEKEREKLEE 598
Query: 389 TGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEP 448
E R E + ++E E + E E+ + + R E
Sbjct: 599 KIEPREPNLEPMVEKQESENSCNKE-----------------EEPVFTRQDSNRSEKEAT 641
Query: 449 GICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERK 508
+ E PE+ + SG F+ + P P +R
Sbjct: 642 PVVHETEPESGSQPRPAVLSGYFKQFQKSLP-----------------------PRFQR- 677
Query: 509 EAAALEQGRKVEELRWQEVDERQTMPRPYTFQVSSGGKQILFPKVNLSPVTPAKDTGLTA 568
Q ++++ +WQ+ ++ +P+ Q SS +
Sbjct: 678 ------QQEQMKQQQWQQQQQQGVLPQTVPSQPSS-----------------------ST 708
Query: 569 APQEPKAPKASPVQHALPSSLSVPHTAILVTGAQLCGPAVNLSQIKDTACKSLLGLEEKK 628
P P P P+Q PH L + P + Q ++ +
Sbjct: 709 VPPPPHRPLYQPMQ---------PHPQHLASMG--FDPRWLMMQSY---------MDPRM 748
Query: 629 HAEAPAGENPPRGPGDARAGSGKAKPRQESPSSASALAEWASIRSRILKNAESDPR---- 684
+ PA + PP PG + + E ++S E + +R + S+PR
Sbjct: 749 MSGRPAMDIPPIHPGMIPPKPLMRRDQMEGSPNSSESFEHIARSARDHAISLSEPRMLWG 808
Query: 685 SSERDQLRPGDESTPRG-------RCDSRGNQRKTPPVNAKFSIMPAWQKFSDGGTETSK 737
S P +TP+ R ++ +Q + + A +S+
Sbjct: 809 SDPYPHAEPQQATTPKATEEPEDVRSEAALDQEQ---ITAAYSV---------------- 849
Query: 738 QSTEAESIRKRPMLGPSEETAPQPPPAGVRELGKGPEKSEMHREPADTTEGCKFAKDLPS 797
+ + E+ K + S E Q + L + E H A+ C A D
Sbjct: 850 EHNQLEAHPKADFIRESSEAQVQ------KFLSRSVEDVRPHHTDANNQSACFEAPD--- 900
Query: 798 FLVPSLPYPPQKVVAHTEFTTS---SDSETANGIAKPDPVMPGGEEKASPFGIKLRRTNY 854
+L P ++ ++ E S S S +N KPD E+++ P + T+
Sbjct: 901 --QKTLSAPQEERISAVESQPSRKRSVSHGSNHTQKPD------EQRSEPSAGIPKVTSR 952
Query: 855 SLRFNCDQQAEQKKKKRHSSTGDSADAGP-------------PAAGSARGEKEMEGVALK 901
+ + ++K K+ S P P S R E+ + +
Sbjct: 953 CIDSKEPIERPEEKPKKEGFIRSSEGPKPEKVYKSKSETRWGPRPSSNRREEVNDRPVRR 1012
Query: 902 HGP-------SLPQERKQAPSTRRDSAEPSSSRSV-------------PVAHPGPP-PAS 940
GP + +ER+Q + AE + + V P P PP P
Sbjct: 1013 SGPIKKPVLRDMKEEREQRKEKEGEKAEKVTEKVVVKPEKTEKKDLPPPPPPPQPPAPIQ 1072
Query: 941 SQTPAPEHDKAANKMPLAQKPALAPKPTSQT-PPASPLSKLSRPYLVELLSRR-----AG 994
Q+ P A K P + LA KP+ T P P+S + V+ ++++
Sbjct: 1073 PQSVPPPIQPEAEKFPSTETATLAQKPSQDTEKPLEPVSTVQVEPAVKTVNQQTMAAPVV 1132
Query: 995 RPDPEPSEPSKEDQESSDRRPPSPPG-PEERKGQKRDEEEEATERKPASPPLPATQQEKP 1053
+ + +P + +D RP S P +E R +EA ER P +
Sbjct: 1133 KEEKQPEKVISKDLVIERPRPDSRPAVKKESTLPPRTYWKEARERDWF--PDQGYRGRGR 1190
Query: 1054 SQTPEAGRKEKPMLQSR------HSLDGSKLTEKVETAQPLWITLALQKQKGFREQQATR 1107
+ GR + R H+ D + + A+ + Q+++ +++
Sbjct: 1191 GEYYSRGRSYRGSYGGRGRGGRGHTRDYPQYRDNKPRAEHIPSGPLRQREESETRSESSD 1250
Query: 1108 EERKQAREAKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPETAVSRLERRE 1167
E R ++ + ++ S+S+ G L K PE K+P S +
Sbjct: 1251 FEVVPKRRRQRGSETDTDSEIHESASDKDSLSK-GKLPKREERPENKKPVKPHSSFKPDN 1309
Query: 1168 QLKKANTLPTSVTVEISDSAPPAPLVK-EVTKR 1199
++ N L V D A P L K E T+R
Sbjct: 1310 HVRIDNRLLEKPYVRDDDKAKPGFLPKGEPTRR 1342
Score = 44.7 bits (104), Expect = 6e-04
Identities = 127/682 (18%), Positives = 230/682 (33%), Gaps = 117/682 (17%)
Query: 625 EEKKHAEAPAGENPPRGPGDARAGSGKAKPRQESPSSASALAEWASIRSRILKNAESDPR 684
++++H E E PP P A + P +S +S + I+ E
Sbjct: 87 KQEQHEEEKTPEVPPAQPKPGVAAPPEVAPAPKSWASNKQGGQGDGIQVNSQFQQEFPSL 146
Query: 685 SSERDQLRPGDESTPRGRCDSRGNQRKTPPVNAKFSIMPAWQKFSDGGTETSKQSTEAES 744
+ DQ + E+ D+ G P N + W+ DGG S+ +
Sbjct: 147 QAAGDQEKKEKETND----DNYGPGPSLRPPN-----VACWR---DGGKAAGSPSSSDQD 194
Query: 745 IRKRPMLGPSEETAPQPPPAGV-----RELGKGPEKSEMHREPADTTEGCKFAKDLPSFL 799
K P G E TA + + + GP +++++ + A ++ +P ++
Sbjct: 195 -EKLP--GQDESTAGTSEQNDILKVVEKRIACGPPQAKLNGQQAALAS--QYRAMMPPYM 249
Query: 800 V---PSLPYPPQKVVAHTEFTTSSDSETANGIAKPDPVMPGGEEKASPFGIKLRRTNYSL 856
P + YPP + F S SET G+ P E P +
Sbjct: 250 FQQYPRMTYPP--LHGPMRFPPSL-SETNKGLRGRGPPPSWASEPERPSILSASELKELD 306
Query: 857 RF-NCDQQAEQ---------------------KKKKRHSSTGDSADAGPPAAGSARGEKE 894
+F N D +A++ ++ +S D G A+ + +KE
Sbjct: 307 KFDNLDAEADEGWAGAQMEVDYTEQLNFSDDDEQGSNSPKENNSEDQGSKASENNENKKE 366
Query: 895 MEGVA------------------LKHGPSLPQERKQA------PSTRRDSAEPSSSRSVP 930
+ V+ GPS QER + P P ++VP
Sbjct: 367 TDEVSNTKSSSQIPAQPSVAKVPYGKGPSFNQERGTSSHLPPPPKLLAQQHPPPDRQAVP 426
Query: 931 VAHPGPPPASSQTPAPEHDKAANKMPLAQKPALAPKPTSQTPPASP-LSKLSRPYLVELL 989
PGP P+ Q + + ++ A + + + + + E L
Sbjct: 427 -GRPGPFPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKL 485
Query: 990 SRRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQ 1049
R + +PS E+ +R +ER+ +K E+E+ ER+ Q
Sbjct: 486 KRLDEKLGILEKQPSPEEIRERERE-------KEREREKELEKEQEQEREKEREKDRERQ 538
Query: 1050 QEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQKGFREQQATREE 1109
QEK + + K++ M + R +L + E + L +K+ +++ EE
Sbjct: 539 QEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEE 598
Query: 1110 RKQAREAK---QAEKLSKEN------------------------VSVSVQPGSSSVSRAG 1142
+ + RE EK EN V +P S S R
Sbjct: 599 KIEPREPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSEKEATPVVHETEPESGSQPRPA 658
Query: 1143 SL-----HKSTALPEEKRPETAVSRLERREQLKKANTLPTSVTVEISDSAPPAPLVKEVT 1197
L +LP + + + ++ +Q ++ LP +V + S S P P + +
Sbjct: 659 VLSGYFKQFQKSLPPRFQRQQEQMKQQQWQQQQQQGVLPQTVPSQPSSSTVPPPPHRPLY 718
Query: 1198 KRFS--TPDAAPVSTEPAWLAL 1217
+ A + +P WL +
Sbjct: 719 QPMQPHPQHLASMGFDPRWLMM 740
Score = 44.7 bits (104), Expect = 6e-04
Identities = 49/179 (27%), Positives = 66/179 (36%), Gaps = 32/179 (17%)
Query: 920 SAEPSSSRSVPVAHPGPPP--ASSQTPAPEHDKAANKMP-----LAQKPALAPKPTSQTP 972
SA +S S P + P P P AS TPA A+ +P LA A P P + +P
Sbjct: 1824 SAAAITSSSAPASAPAPTPILASVSTPASVTILASASIPILASALASTSAPTPAPAASSP 1883
Query: 973 PA----SPLSKLSRPYL-VELLSRRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQ 1027
A +P S P V L A P P P+ S + P+PP P + + Q
Sbjct: 1884 AAPVITAPTIPASAPTASVPLAPASASAPAPAPTPVSAPN--------PAPPAPAQTQAQ 1935
Query: 1028 KRDEEEEATERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQ 1086
KP PL T Q P P Q+ + D + ++T Q
Sbjct: 1936 ---------THKPVQNPLQTTSQSSKQPPPSI---RLPSAQTPNGTDYVASGKSIQTPQ 1982
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sapiens]
Length = 1293
Score = 91.7 bits (226), Expect = 4e-18
Identities = 96/295 (32%), Positives = 146/295 (49%), Gaps = 36/295 (12%)
Query: 209 EEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQE 268
E E EEER+RQE+ R+ E +RQ+ E ++R EE L RR EE R++
Sbjct: 737 EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEE-----LARRKQEEALRRQ 791
Query: 269 LLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEE----ERRRLQ 324
E+E + E ER +EE R LE E+ ERR++EE R + EE R +
Sbjct: 792 -REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEE 850
Query: 325 AQAQAEERR-RLEED-ARL---EERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEV 379
AQ + EE R R+EE+ ARL EE R+++E E + +EL RQ +++ E L+QQ+ +
Sbjct: 851 AQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQ 910
Query: 380 QGPPEALEETGE-GRRG-------------AEEEDLGEEEEEGQAHLEDWRGQLSELLND 425
Q L + G++ AE + L EEE E Q E+ R Q EL+
Sbjct: 911 QLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKL-EEERERQLR-EEQRRQQRELMKA 968
Query: 426 FEERLEDQERLKPEGQREHSEEPG----ICEEQNPEAERRREQQGRSGDFQGADR 476
+++ + Q++ K G S+ G + E Q EA + ++QQ + Q +R
Sbjct: 969 LQQQ-QQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNR 1022
Score = 87.4 bits (215), Expect = 7e-17
Identities = 72/201 (35%), Positives = 103/201 (51%), Gaps = 14/201 (6%)
Query: 238 QKAEAAEKRRLEEQRLQALER--RLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSL 295
Q+ E A+ +LE++R +A R R EE +RQE L + E E R +EE+++
Sbjct: 721 QQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQE------EILRRQQEEERKRR 774
Query: 296 EAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCA 355
E E+ RR++EE R + E+E L+ Q + EER++ EE R E RR+EEEE R
Sbjct: 775 EE---EELARRKQEEALRRQREQEIA-LRRQREEEERQQQEEALRRLEERRREEEERRKQ 830
Query: 356 EELKRQEEEEAEGW--EELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLE 413
EEL R++EEEA W EE E Q + EE R EE E E + Q L
Sbjct: 831 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELM 890
Query: 414 DWRGQLSELLNDFEERLEDQE 434
R Q E L +++ + Q+
Sbjct: 891 RQRQQQQEALRRLQQQQQQQQ 911
Score = 76.6 bits (187), Expect = 1e-13
Identities = 81/285 (28%), Positives = 121/285 (42%), Gaps = 26/285 (9%)
Query: 260 LWE--ENRRQELLEEEGEGQEPPLEAER-APREEQQRSLEAPGWEDAERREREERERLEA 316
+WE Q + E G + PL+ P EQ + LE E+ RE R +
Sbjct: 685 IWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKR 744
Query: 317 EEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEE--LKRQEEEEAEGWEELEQ 374
EEE R+ Q + + ++ L E +RR+EEE R +E L+RQ E+E + E+
Sbjct: 745 EEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREE 804
Query: 375 QEAEVQGPPEALEETGEGRRGAEE----EDL-----------GEEEEEGQAHLEDWRGQL 419
+E + Q EAL E RR EE E+L EEEE Q LE+ R ++
Sbjct: 805 EERQQQ--EEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRM 862
Query: 420 SELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGP 479
E R E++ER + E + + +E +Q EA RR +QQ + P
Sbjct: 863 EE--EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSS 920
Query: 480 EEKREEGDTEPLLKQE--GPVEAAQPPVERKEAAALEQGRKVEEL 522
++ +T Q E + ER+ EQ R+ EL
Sbjct: 921 STWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQREL 965
Score = 61.6 bits (148), Expect = 4e-09
Identities = 90/389 (23%), Positives = 152/389 (39%), Gaps = 89/389 (22%)
Query: 79 MEIVTQQDIVLSDAENKSSDTPSSLSPLNLPGAGSEMEEKVAPVKPSRPKRHFSSAGTIE 138
+ ++ QQ L + + PS +++P GS E ++P+ + G++
Sbjct: 650 LALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWE-----LQPTASQPTVWEGGSVW 704
Query: 139 SVNLDAI-PLAIARLDNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQN 197
+ LD P K K A +++R ++ + ++ + Q L +
Sbjct: 705 DLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILR 764
Query: 198 GHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALE 257
E++ EEE EE RRQ RE E +RQ+ E E+R+ +E+ L+ LE
Sbjct: 765 RQQEEERKRREEEELARRKQEEALRRQ----REQEIALRRQREE--EERQQQEEALRRLE 818
Query: 258 --RRLWEENRRQE--LLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERER 313
RR EE R+QE L ++E E + E E A R ++ L R E EER+R
Sbjct: 819 ERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKR 878
Query: 314 LEAEEER---------------RRLQAQAQAE---------------------------- 330
E E +R RRLQ Q Q +
Sbjct: 879 KELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATL 938
Query: 331 ---ERRRLEEDARL---EERRRQEEEEGRCAEELKRQEEEEAEGW--------------- 369
E ++LEE+ EE+RRQ+ E + ++ ++Q++++ GW
Sbjct: 939 SLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLE 998
Query: 370 ---------EELEQQEAEVQGPPEALEET 389
++ +QQ+ + Q P A T
Sbjct: 999 IQQEEARQMQKQQQQQQQHQQPNRARNNT 1027
Score = 38.9 bits (89), Expect = 0.031
Identities = 62/267 (23%), Positives = 99/267 (37%), Gaps = 27/267 (10%)
Query: 236 KRQKAEAAEKRRLEEQRLQALERRLWEEN------RRQELLEEEGEGQEPPLEAERAPRE 289
+ Q E RR E+ + + R +EE R+ E + E E R RE
Sbjct: 157 RSQSWEERGDRRFEKPGRKDVGRPNFEEGGPTSVGRKHEFIRSESENW-------RIFRE 209
Query: 290 EQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEE 349
EQ E GW A R ER R + R + E RRR E D R R +E
Sbjct: 210 EQNGEDEDGGWRLAGSRRDGERWRPHSPGWREHM------ERRRRFEFDF----RDRDDE 259
Query: 350 EEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQ 409
R +++ + E ++AE + + ++E + EE+E
Sbjct: 260 RGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDF 319
Query: 410 AHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGI-CEEQNPEAERRREQQGRS 468
+++ + EE E + K EG E ++ G+ E+ P+ + G
Sbjct: 320 RPVDEGEECSDSEGSHNEEAKEPDKTNKKEG--EKTDRVGVEASEETPQTSSSSARPGTP 377
Query: 469 GDFQGADRPGPEEKREEGDTEPLLKQE 495
D Q + E+++E TE K E
Sbjct: 378 SDHQ-SQEASQFERKDEPKTEQTEKAE 403
Score = 35.8 bits (81), Expect = 0.26
Identities = 44/189 (23%), Positives = 83/189 (43%), Gaps = 13/189 (6%)
Query: 995 RPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQEKPS 1054
+ + E ++ ++E++E+ R + EE + R EEEE +RK +
Sbjct: 836 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEER-KRKELEVQRQKELMRQRQ 894
Query: 1055 QTPEAGRKEKPMLQSRHSLDGSKLT-------EKVETAQPLWITLAL---QKQKGFREQQ 1104
Q EA R+ + Q + L KL + TA TL+L QK + RE+Q
Sbjct: 895 QQQEALRRLQQQ-QQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQ 953
Query: 1105 ATREERKQAREAKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPETAVSRLE 1164
E+R+Q RE +A + ++ + G +VS+ KS +++ + +
Sbjct: 954 LREEQRRQQRELMKALQQQQQQQQQKLS-GWGNVSKPSGTTKSLLEIQQEEARQMQKQQQ 1012
Query: 1165 RREQLKKAN 1173
+++Q ++ N
Sbjct: 1013 QQQQHQQPN 1021
Score = 35.0 bits (79), Expect = 0.44
Identities = 53/254 (20%), Positives = 101/254 (39%), Gaps = 27/254 (10%)
Query: 923 PSSSRSVPVAHPGP----PPASSQTPAPEHDKAANKMPLAQKPALAPKPTSQTPPASPLS 978
PS +RSV V G P +SQ P + +PL T+ P L
Sbjct: 671 PSVTRSVSVPDTGSIWELQPTASQ-PTVWEGGSVWDLPL--------DTTTPGPALEQLQ 721
Query: 979 KLSRPYLVEL-LSRRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATE 1037
+L + +L RR + E ++ QE R+ ++ + +KR EEEE
Sbjct: 722 QLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELAR 781
Query: 1038 RKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQ 1097
RK +QE + + + ++ L+ + E+ Q +
Sbjct: 782 RKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ----------E 831
Query: 1098 KGFREQQATREERKQAREAKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPE 1157
+ R+Q+ E K ARE ++A++ +EN + ++ ++ + K L +++ E
Sbjct: 832 ELLRKQE--EEAAKWAREEEEAQRRLEEN-RLRMEEEAARLRHEEEERKRKELEVQRQKE 888
Query: 1158 TAVSRLERREQLKK 1171
R +++E L++
Sbjct: 889 LMRQRQQQQEALRR 902
Score = 34.3 bits (77), Expect = 0.75
Identities = 56/272 (20%), Positives = 102/272 (37%), Gaps = 30/272 (11%)
Query: 216 DSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGE 275
D+EEE + L K K QK E++ ++ + + E E E +E +
Sbjct: 286 DAEEEMGTFDSSGAFLSLK-KVQKEPIPEEQEMDFRPVDEGEECSDSEGSHNEEAKEPDK 344
Query: 276 GQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRL 335
+ E E+ R + S E P + R + E + + + + E+ +
Sbjct: 345 TNKK--EGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKA 402
Query: 336 EEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGP----PEALEETGE 391
EE+ R+ E A+ R +E A+ + L Q ++ P P +
Sbjct: 403 EEETRM--------ENSLPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPVPNPSP 454
Query: 392 GRRGAEEEDLG----------EEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQ 441
R E +G ++EEG HLE Q +++ ++ D ERL + Q
Sbjct: 455 TLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQ---QAEKMVAYLQDSALDDERLASKLQ 511
Query: 442 REHSEEPGICEEQNPEAERRREQQGRSGDFQG 473
++ G+ EA ++ + G+ QG
Sbjct: 512 EHRAK--GVSIPLMHEAMQKWYYKDPQGEIQG 541
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 91.7 bits (226), Expect = 4e-18
Identities = 96/295 (32%), Positives = 146/295 (49%), Gaps = 36/295 (12%)
Query: 209 EEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQE 268
E E EEER+RQE+ R+ E +RQ+ E ++R EE L RR EE R++
Sbjct: 764 EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEE-----LARRKQEEALRRQ 818
Query: 269 LLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEE----ERRRLQ 324
E+E + E ER +EE R LE E+ ERR++EE R + EE R +
Sbjct: 819 -REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEE 877
Query: 325 AQAQAEERR-RLEED-ARL---EERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEV 379
AQ + EE R R+EE+ ARL EE R+++E E + +EL RQ +++ E L+QQ+ +
Sbjct: 878 AQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQ 937
Query: 380 QGPPEALEETGE-GRRG-------------AEEEDLGEEEEEGQAHLEDWRGQLSELLND 425
Q L + G++ AE + L EEE E Q E+ R Q EL+
Sbjct: 938 QLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKL-EEERERQLR-EEQRRQQRELMKA 995
Query: 426 FEERLEDQERLKPEGQREHSEEPG----ICEEQNPEAERRREQQGRSGDFQGADR 476
+++ + Q++ K G S+ G + E Q EA + ++QQ + Q +R
Sbjct: 996 LQQQ-QQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNR 1049
Score = 87.4 bits (215), Expect = 7e-17
Identities = 72/201 (35%), Positives = 103/201 (51%), Gaps = 14/201 (6%)
Query: 238 QKAEAAEKRRLEEQRLQALER--RLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSL 295
Q+ E A+ +LE++R +A R R EE +RQE L + E E R +EE+++
Sbjct: 748 QQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQE------EILRRQQEEERKRR 801
Query: 296 EAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCA 355
E E+ RR++EE R + E+E L+ Q + EER++ EE R E RR+EEEE R
Sbjct: 802 EE---EELARRKQEEALRRQREQEIA-LRRQREEEERQQQEEALRRLEERRREEEERRKQ 857
Query: 356 EELKRQEEEEAEGW--EELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLE 413
EEL R++EEEA W EE E Q + EE R EE E E + Q L
Sbjct: 858 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELM 917
Query: 414 DWRGQLSELLNDFEERLEDQE 434
R Q E L +++ + Q+
Sbjct: 918 RQRQQQQEALRRLQQQQQQQQ 938
Score = 76.6 bits (187), Expect = 1e-13
Identities = 81/285 (28%), Positives = 121/285 (42%), Gaps = 26/285 (9%)
Query: 260 LWE--ENRRQELLEEEGEGQEPPLEAER-APREEQQRSLEAPGWEDAERREREERERLEA 316
+WE Q + E G + PL+ P EQ + LE E+ RE R +
Sbjct: 712 IWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKR 771
Query: 317 EEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEE--LKRQEEEEAEGWEELEQ 374
EEE R+ Q + + ++ L E +RR+EEE R +E L+RQ E+E + E+
Sbjct: 772 EEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREE 831
Query: 375 QEAEVQGPPEALEETGEGRRGAEE----EDL-----------GEEEEEGQAHLEDWRGQL 419
+E + Q EAL E RR EE E+L EEEE Q LE+ R ++
Sbjct: 832 EERQQQ--EEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRM 889
Query: 420 SELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGP 479
E R E++ER + E + + +E +Q EA RR +QQ + P
Sbjct: 890 EE--EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSS 947
Query: 480 EEKREEGDTEPLLKQE--GPVEAAQPPVERKEAAALEQGRKVEEL 522
++ +T Q E + ER+ EQ R+ EL
Sbjct: 948 STWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQREL 992
Score = 61.6 bits (148), Expect = 4e-09
Identities = 90/389 (23%), Positives = 152/389 (39%), Gaps = 89/389 (22%)
Query: 79 MEIVTQQDIVLSDAENKSSDTPSSLSPLNLPGAGSEMEEKVAPVKPSRPKRHFSSAGTIE 138
+ ++ QQ L + + PS +++P GS E ++P+ + G++
Sbjct: 677 LALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWE-----LQPTASQPTVWEGGSVW 731
Query: 139 SVNLDAI-PLAIARLDNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQN 197
+ LD P K K A +++R ++ + ++ + Q L +
Sbjct: 732 DLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILR 791
Query: 198 GHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALE 257
E++ EEE EE RRQ RE E +RQ+ E E+R+ +E+ L+ LE
Sbjct: 792 RQQEEERKRREEEELARRKQEEALRRQ----REQEIALRRQREE--EERQQQEEALRRLE 845
Query: 258 --RRLWEENRRQE--LLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERER 313
RR EE R+QE L ++E E + E E A R ++ L R E EER+R
Sbjct: 846 ERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKR 905
Query: 314 LEAEEER---------------RRLQAQAQAE---------------------------- 330
E E +R RRLQ Q Q +
Sbjct: 906 KELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATL 965
Query: 331 ---ERRRLEEDARL---EERRRQEEEEGRCAEELKRQEEEEAEGW--------------- 369
E ++LEE+ EE+RRQ+ E + ++ ++Q++++ GW
Sbjct: 966 SLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLE 1025
Query: 370 ---------EELEQQEAEVQGPPEALEET 389
++ +QQ+ + Q P A T
Sbjct: 1026 IQQEEARQMQKQQQQQQQHQQPNRARNNT 1054
Score = 45.1 bits (105), Expect = 4e-04
Identities = 54/231 (23%), Positives = 87/231 (37%), Gaps = 14/231 (6%)
Query: 265 RRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQ 324
R+ E + E E R REEQ E GW A R ER R + + R
Sbjct: 214 RKHEFIRSESENW-------RIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSAG 266
Query: 325 AQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPE 384
+ E RRR E D R R +E R +++ + E ++AE +
Sbjct: 267 WREHMERRRRFEFDF----RDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTF 322
Query: 385 ALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREH 444
+ ++E + EE+E +++ + EE E + K EG E
Sbjct: 323 DSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHNEEAKEPDKTNKKEG--EK 380
Query: 445 SEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQE 495
++ G+ E+ P+ + G D Q + E+++E TE K E
Sbjct: 381 TDRVGVASEETPQTSSSSARPGTPSDHQ-SQEASQFERKDEPKTEQTEKAE 430
Score = 35.8 bits (81), Expect = 0.26
Identities = 44/189 (23%), Positives = 83/189 (43%), Gaps = 13/189 (6%)
Query: 995 RPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQEKPS 1054
+ + E ++ ++E++E+ R + EE + R EEEE +RK +
Sbjct: 863 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEER-KRKELEVQRQKELMRQRQ 921
Query: 1055 QTPEAGRKEKPMLQSRHSLDGSKLT-------EKVETAQPLWITLAL---QKQKGFREQQ 1104
Q EA R+ + Q + L KL + TA TL+L QK + RE+Q
Sbjct: 922 QQQEALRRLQQQ-QQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQ 980
Query: 1105 ATREERKQAREAKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPETAVSRLE 1164
E+R+Q RE +A + ++ + G +VS+ KS +++ + +
Sbjct: 981 LREEQRRQQRELMKALQQQQQQQQQKLS-GWGNVSKPSGTTKSLLEIQQEEARQMQKQQQ 1039
Query: 1165 RREQLKKAN 1173
+++Q ++ N
Sbjct: 1040 QQQQHQQPN 1048
Score = 35.0 bits (79), Expect = 0.44
Identities = 53/254 (20%), Positives = 101/254 (39%), Gaps = 27/254 (10%)
Query: 923 PSSSRSVPVAHPGP----PPASSQTPAPEHDKAANKMPLAQKPALAPKPTSQTPPASPLS 978
PS +RSV V G P +SQ P + +PL T+ P L
Sbjct: 698 PSVTRSVSVPDTGSIWELQPTASQ-PTVWEGGSVWDLPL--------DTTTPGPALEQLQ 748
Query: 979 KLSRPYLVEL-LSRRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATE 1037
+L + +L RR + E ++ QE R+ ++ + +KR EEEE
Sbjct: 749 QLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELAR 808
Query: 1038 RKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQ 1097
RK +QE + + + ++ L+ + E+ Q +
Sbjct: 809 RKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ----------E 858
Query: 1098 KGFREQQATREERKQAREAKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPE 1157
+ R+Q+ E K ARE ++A++ +EN + ++ ++ + K L +++ E
Sbjct: 859 ELLRKQE--EEAAKWAREEEEAQRRLEEN-RLRMEEEAARLRHEEEERKRKELEVQRQKE 915
Query: 1158 TAVSRLERREQLKK 1171
R +++E L++
Sbjct: 916 LMRQRQQQQEALRR 929
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 91.7 bits (226), Expect = 4e-18
Identities = 96/295 (32%), Positives = 146/295 (49%), Gaps = 36/295 (12%)
Query: 209 EEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQE 268
E E EEER+RQE+ R+ E +RQ+ E ++R EE L RR EE R++
Sbjct: 743 EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEE-----LARRKQEEALRRQ 797
Query: 269 LLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEE----ERRRLQ 324
E+E + E ER +EE R LE E+ ERR++EE R + EE R +
Sbjct: 798 -REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEE 856
Query: 325 AQAQAEERR-RLEED-ARL---EERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEV 379
AQ + EE R R+EE+ ARL EE R+++E E + +EL RQ +++ E L+QQ+ +
Sbjct: 857 AQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQ 916
Query: 380 QGPPEALEETGE-GRRG-------------AEEEDLGEEEEEGQAHLEDWRGQLSELLND 425
Q L + G++ AE + L EEE E Q E+ R Q EL+
Sbjct: 917 QLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKL-EEERERQLR-EEQRRQQRELMKA 974
Query: 426 FEERLEDQERLKPEGQREHSEEPG----ICEEQNPEAERRREQQGRSGDFQGADR 476
+++ + Q++ K G S+ G + E Q EA + ++QQ + Q +R
Sbjct: 975 LQQQ-QQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNR 1028
Score = 87.4 bits (215), Expect = 7e-17
Identities = 72/201 (35%), Positives = 103/201 (51%), Gaps = 14/201 (6%)
Query: 238 QKAEAAEKRRLEEQRLQALER--RLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSL 295
Q+ E A+ +LE++R +A R R EE +RQE L + E E R +EE+++
Sbjct: 727 QQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQE------EILRRQQEEERKRR 780
Query: 296 EAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCA 355
E E+ RR++EE R + E+E L+ Q + EER++ EE R E RR+EEEE R
Sbjct: 781 EE---EELARRKQEEALRRQREQEIA-LRRQREEEERQQQEEALRRLEERRREEEERRKQ 836
Query: 356 EELKRQEEEEAEGW--EELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLE 413
EEL R++EEEA W EE E Q + EE R EE E E + Q L
Sbjct: 837 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELM 896
Query: 414 DWRGQLSELLNDFEERLEDQE 434
R Q E L +++ + Q+
Sbjct: 897 RQRQQQQEALRRLQQQQQQQQ 917
Score = 76.6 bits (187), Expect = 1e-13
Identities = 81/285 (28%), Positives = 121/285 (42%), Gaps = 26/285 (9%)
Query: 260 LWE--ENRRQELLEEEGEGQEPPLEAER-APREEQQRSLEAPGWEDAERREREERERLEA 316
+WE Q + E G + PL+ P EQ + LE E+ RE R +
Sbjct: 691 IWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKR 750
Query: 317 EEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEE--LKRQEEEEAEGWEELEQ 374
EEE R+ Q + + ++ L E +RR+EEE R +E L+RQ E+E + E+
Sbjct: 751 EEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREE 810
Query: 375 QEAEVQGPPEALEETGEGRRGAEE----EDL-----------GEEEEEGQAHLEDWRGQL 419
+E + Q EAL E RR EE E+L EEEE Q LE+ R ++
Sbjct: 811 EERQQQ--EEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRM 868
Query: 420 SELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGP 479
E R E++ER + E + + +E +Q EA RR +QQ + P
Sbjct: 869 EE--EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSS 926
Query: 480 EEKREEGDTEPLLKQE--GPVEAAQPPVERKEAAALEQGRKVEEL 522
++ +T Q E + ER+ EQ R+ EL
Sbjct: 927 STWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQREL 971
Score = 61.6 bits (148), Expect = 4e-09
Identities = 90/389 (23%), Positives = 152/389 (39%), Gaps = 89/389 (22%)
Query: 79 MEIVTQQDIVLSDAENKSSDTPSSLSPLNLPGAGSEMEEKVAPVKPSRPKRHFSSAGTIE 138
+ ++ QQ L + + PS +++P GS E ++P+ + G++
Sbjct: 656 LALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWE-----LQPTASQPTVWEGGSVW 710
Query: 139 SVNLDAI-PLAIARLDNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQN 197
+ LD P K K A +++R ++ + ++ + Q L +
Sbjct: 711 DLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILR 770
Query: 198 GHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALE 257
E++ EEE EE RRQ RE E +RQ+ E E+R+ +E+ L+ LE
Sbjct: 771 RQQEEERKRREEEELARRKQEEALRRQ----REQEIALRRQREE--EERQQQEEALRRLE 824
Query: 258 --RRLWEENRRQE--LLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERER 313
RR EE R+QE L ++E E + E E A R ++ L R E EER+R
Sbjct: 825 ERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKR 884
Query: 314 LEAEEER---------------RRLQAQAQAE---------------------------- 330
E E +R RRLQ Q Q +
Sbjct: 885 KELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATL 944
Query: 331 ---ERRRLEEDARL---EERRRQEEEEGRCAEELKRQEEEEAEGW--------------- 369
E ++LEE+ EE+RRQ+ E + ++ ++Q++++ GW
Sbjct: 945 SLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLE 1004
Query: 370 ---------EELEQQEAEVQGPPEALEET 389
++ +QQ+ + Q P A T
Sbjct: 1005 IQQEEARQMQKQQQQQQQHQQPNRARNNT 1033
Score = 42.7 bits (99), Expect = 0.002
Identities = 62/267 (23%), Positives = 100/267 (37%), Gaps = 21/267 (7%)
Query: 236 KRQKAEAAEKRRLEEQRLQALERRLWEEN------RRQELLEEEGEGQEPPLEAERAPRE 289
+ Q E RR E+ + + R +EE R+ E + E E R RE
Sbjct: 157 RSQSWEERGDRRFEKPGRKDVGRPNFEEGGPTSVGRKHEFIRSESENW-------RIFRE 209
Query: 290 EQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEE 349
EQ E GW A R ER R + + R + E RRR E D R R +E
Sbjct: 210 EQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSAGWREHMERRRRFEFDF----RDRDDE 265
Query: 350 EEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQ 409
R +++ + E ++AE + + ++E + EE+E
Sbjct: 266 RGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDF 325
Query: 410 AHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGI-CEEQNPEAERRREQQGRS 468
+++ + EE E + K EG E ++ G+ E+ P+ + G
Sbjct: 326 RPVDEGEECSDSEGSHNEEAKEPDKTNKKEG--EKTDRVGVEASEETPQTSSSSARPGTP 383
Query: 469 GDFQGADRPGPEEKREEGDTEPLLKQE 495
D Q + E+++E TE K E
Sbjct: 384 SDHQ-SQEASQFERKDEPKTEQTEKAE 409
Score = 35.8 bits (81), Expect = 0.26
Identities = 44/189 (23%), Positives = 83/189 (43%), Gaps = 13/189 (6%)
Query: 995 RPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQEKPS 1054
+ + E ++ ++E++E+ R + EE + R EEEE +RK +
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEER-KRKELEVQRQKELMRQRQ 900
Query: 1055 QTPEAGRKEKPMLQSRHSLDGSKLT-------EKVETAQPLWITLAL---QKQKGFREQQ 1104
Q EA R+ + Q + L KL + TA TL+L QK + RE+Q
Sbjct: 901 QQQEALRRLQQQ-QQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQ 959
Query: 1105 ATREERKQAREAKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPETAVSRLE 1164
E+R+Q RE +A + ++ + G +VS+ KS +++ + +
Sbjct: 960 LREEQRRQQRELMKALQQQQQQQQQKLS-GWGNVSKPSGTTKSLLEIQQEEARQMQKQQQ 1018
Query: 1165 RREQLKKAN 1173
+++Q ++ N
Sbjct: 1019 QQQQHQQPN 1027
Score = 35.0 bits (79), Expect = 0.44
Identities = 53/254 (20%), Positives = 101/254 (39%), Gaps = 27/254 (10%)
Query: 923 PSSSRSVPVAHPGP----PPASSQTPAPEHDKAANKMPLAQKPALAPKPTSQTPPASPLS 978
PS +RSV V G P +SQ P + +PL T+ P L
Sbjct: 677 PSVTRSVSVPDTGSIWELQPTASQ-PTVWEGGSVWDLPL--------DTTTPGPALEQLQ 727
Query: 979 KLSRPYLVEL-LSRRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATE 1037
+L + +L RR + E ++ QE R+ ++ + +KR EEEE
Sbjct: 728 QLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELAR 787
Query: 1038 RKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQ 1097
RK +QE + + + ++ L+ + E+ Q +
Sbjct: 788 RKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ----------E 837
Query: 1098 KGFREQQATREERKQAREAKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPE 1157
+ R+Q+ E K ARE ++A++ +EN + ++ ++ + K L +++ E
Sbjct: 838 ELLRKQE--EEAAKWAREEEEAQRRLEEN-RLRMEEEAARLRHEEEERKRKELEVQRQKE 894
Query: 1158 TAVSRLERREQLKK 1171
R +++E L++
Sbjct: 895 LMRQRQQQQEALRR 908
Score = 34.3 bits (77), Expect = 0.75
Identities = 56/272 (20%), Positives = 102/272 (37%), Gaps = 30/272 (11%)
Query: 216 DSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGE 275
D+EEE + L K K QK E++ ++ + + E E E +E +
Sbjct: 292 DAEEEMGTFDSSGAFLSLK-KVQKEPIPEEQEMDFRPVDEGEECSDSEGSHNEEAKEPDK 350
Query: 276 GQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRL 335
+ E E+ R + S E P + R + E + + + + E+ +
Sbjct: 351 TNKK--EGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKA 408
Query: 336 EEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGP----PEALEETGE 391
EE+ R+ E A+ R +E A+ + L Q ++ P P +
Sbjct: 409 EEETRM--------ENSLPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPVPNPSP 460
Query: 392 GRRGAEEEDLG----------EEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQ 441
R E +G ++EEG HLE Q +++ ++ D ERL + Q
Sbjct: 461 TLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQ---QAEKMVAYLQDSALDDERLASKLQ 517
Query: 442 REHSEEPGICEEQNPEAERRREQQGRSGDFQG 473
++ G+ EA ++ + G+ QG
Sbjct: 518 EHRAK--GVSIPLMHEAMQKWYYKDPQGEIQG 547
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 91.7 bits (226), Expect = 4e-18
Identities = 96/295 (32%), Positives = 146/295 (49%), Gaps = 36/295 (12%)
Query: 209 EEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQE 268
E E EEER+RQE+ R+ E +RQ+ E ++R EE L RR EE R++
Sbjct: 743 EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEE-----LARRKQEEALRRQ 797
Query: 269 LLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEE----ERRRLQ 324
E+E + E ER +EE R LE E+ ERR++EE R + EE R +
Sbjct: 798 -REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEE 856
Query: 325 AQAQAEERR-RLEED-ARL---EERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEV 379
AQ + EE R R+EE+ ARL EE R+++E E + +EL RQ +++ E L+QQ+ +
Sbjct: 857 AQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQ 916
Query: 380 QGPPEALEETGE-GRRG-------------AEEEDLGEEEEEGQAHLEDWRGQLSELLND 425
Q L + G++ AE + L EEE E Q E+ R Q EL+
Sbjct: 917 QLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKL-EEERERQLR-EEQRRQQRELMKA 974
Query: 426 FEERLEDQERLKPEGQREHSEEPG----ICEEQNPEAERRREQQGRSGDFQGADR 476
+++ + Q++ K G S+ G + E Q EA + ++QQ + Q +R
Sbjct: 975 LQQQ-QQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNR 1028
Score = 87.4 bits (215), Expect = 7e-17
Identities = 72/201 (35%), Positives = 103/201 (51%), Gaps = 14/201 (6%)
Query: 238 QKAEAAEKRRLEEQRLQALER--RLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSL 295
Q+ E A+ +LE++R +A R R EE +RQE L + E E R +EE+++
Sbjct: 727 QQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQE------EILRRQQEEERKRR 780
Query: 296 EAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCA 355
E E+ RR++EE R + E+E L+ Q + EER++ EE R E RR+EEEE R
Sbjct: 781 EE---EELARRKQEEALRRQREQEIA-LRRQREEEERQQQEEALRRLEERRREEEERRKQ 836
Query: 356 EELKRQEEEEAEGW--EELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLE 413
EEL R++EEEA W EE E Q + EE R EE E E + Q L
Sbjct: 837 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELM 896
Query: 414 DWRGQLSELLNDFEERLEDQE 434
R Q E L +++ + Q+
Sbjct: 897 RQRQQQQEALRRLQQQQQQQQ 917
Score = 76.6 bits (187), Expect = 1e-13
Identities = 81/285 (28%), Positives = 121/285 (42%), Gaps = 26/285 (9%)
Query: 260 LWE--ENRRQELLEEEGEGQEPPLEAER-APREEQQRSLEAPGWEDAERREREERERLEA 316
+WE Q + E G + PL+ P EQ + LE E+ RE R +
Sbjct: 691 IWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKR 750
Query: 317 EEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEE--LKRQEEEEAEGWEELEQ 374
EEE R+ Q + + ++ L E +RR+EEE R +E L+RQ E+E + E+
Sbjct: 751 EEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREE 810
Query: 375 QEAEVQGPPEALEETGEGRRGAEE----EDL-----------GEEEEEGQAHLEDWRGQL 419
+E + Q EAL E RR EE E+L EEEE Q LE+ R ++
Sbjct: 811 EERQQQ--EEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRM 868
Query: 420 SELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGP 479
E R E++ER + E + + +E +Q EA RR +QQ + P
Sbjct: 869 EE--EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSS 926
Query: 480 EEKREEGDTEPLLKQE--GPVEAAQPPVERKEAAALEQGRKVEEL 522
++ +T Q E + ER+ EQ R+ EL
Sbjct: 927 STWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQREL 971
Score = 61.6 bits (148), Expect = 4e-09
Identities = 90/389 (23%), Positives = 152/389 (39%), Gaps = 89/389 (22%)
Query: 79 MEIVTQQDIVLSDAENKSSDTPSSLSPLNLPGAGSEMEEKVAPVKPSRPKRHFSSAGTIE 138
+ ++ QQ L + + PS +++P GS E ++P+ + G++
Sbjct: 656 LALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWE-----LQPTASQPTVWEGGSVW 710
Query: 139 SVNLDAI-PLAIARLDNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQN 197
+ LD P K K A +++R ++ + ++ + Q L +
Sbjct: 711 DLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILR 770
Query: 198 GHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALE 257
E++ EEE EE RRQ RE E +RQ+ E E+R+ +E+ L+ LE
Sbjct: 771 RQQEEERKRREEEELARRKQEEALRRQ----REQEIALRRQREE--EERQQQEEALRRLE 824
Query: 258 --RRLWEENRRQE--LLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERER 313
RR EE R+QE L ++E E + E E A R ++ L R E EER+R
Sbjct: 825 ERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKR 884
Query: 314 LEAEEER---------------RRLQAQAQAE---------------------------- 330
E E +R RRLQ Q Q +
Sbjct: 885 KELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATL 944
Query: 331 ---ERRRLEEDARL---EERRRQEEEEGRCAEELKRQEEEEAEGW--------------- 369
E ++LEE+ EE+RRQ+ E + ++ ++Q++++ GW
Sbjct: 945 SLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLE 1004
Query: 370 ---------EELEQQEAEVQGPPEALEET 389
++ +QQ+ + Q P A T
Sbjct: 1005 IQQEEARQMQKQQQQQQQHQQPNRARNNT 1033
Score = 42.7 bits (99), Expect = 0.002
Identities = 62/267 (23%), Positives = 100/267 (37%), Gaps = 21/267 (7%)
Query: 236 KRQKAEAAEKRRLEEQRLQALERRLWEEN------RRQELLEEEGEGQEPPLEAERAPRE 289
+ Q E RR E+ + + R +EE R+ E + E E R RE
Sbjct: 157 RSQSWEERGDRRFEKPGRKDVGRPNFEEGGPTSVGRKHEFIRSESENW-------RIFRE 209
Query: 290 EQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEE 349
EQ E GW A R ER R + + R + E RRR E D R R +E
Sbjct: 210 EQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSAGWREHMERRRRFEFDF----RDRDDE 265
Query: 350 EEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQ 409
R +++ + E ++AE + + ++E + EE+E
Sbjct: 266 RGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDF 325
Query: 410 AHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGI-CEEQNPEAERRREQQGRS 468
+++ + EE E + K EG E ++ G+ E+ P+ + G
Sbjct: 326 RPVDEGEECSDSEGSHNEEAKEPDKTNKKEG--EKTDRVGVEASEETPQTSSSSARPGTP 383
Query: 469 GDFQGADRPGPEEKREEGDTEPLLKQE 495
D Q + E+++E TE K E
Sbjct: 384 SDHQ-SQEASQFERKDEPKTEQTEKAE 409
Score = 35.8 bits (81), Expect = 0.26
Identities = 44/189 (23%), Positives = 83/189 (43%), Gaps = 13/189 (6%)
Query: 995 RPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQEKPS 1054
+ + E ++ ++E++E+ R + EE + R EEEE +RK +
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEER-KRKELEVQRQKELMRQRQ 900
Query: 1055 QTPEAGRKEKPMLQSRHSLDGSKLT-------EKVETAQPLWITLAL---QKQKGFREQQ 1104
Q EA R+ + Q + L KL + TA TL+L QK + RE+Q
Sbjct: 901 QQQEALRRLQQQ-QQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQ 959
Query: 1105 ATREERKQAREAKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPETAVSRLE 1164
E+R+Q RE +A + ++ + G +VS+ KS +++ + +
Sbjct: 960 LREEQRRQQRELMKALQQQQQQQQQKLS-GWGNVSKPSGTTKSLLEIQQEEARQMQKQQQ 1018
Query: 1165 RREQLKKAN 1173
+++Q ++ N
Sbjct: 1019 QQQQHQQPN 1027
Score = 35.0 bits (79), Expect = 0.44
Identities = 53/254 (20%), Positives = 101/254 (39%), Gaps = 27/254 (10%)
Query: 923 PSSSRSVPVAHPGP----PPASSQTPAPEHDKAANKMPLAQKPALAPKPTSQTPPASPLS 978
PS +RSV V G P +SQ P + +PL T+ P L
Sbjct: 677 PSVTRSVSVPDTGSIWELQPTASQ-PTVWEGGSVWDLPL--------DTTTPGPALEQLQ 727
Query: 979 KLSRPYLVEL-LSRRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATE 1037
+L + +L RR + E ++ QE R+ ++ + +KR EEEE
Sbjct: 728 QLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELAR 787
Query: 1038 RKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQ 1097
RK +QE + + + ++ L+ + E+ Q +
Sbjct: 788 RKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ----------E 837
Query: 1098 KGFREQQATREERKQAREAKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRPE 1157
+ R+Q+ E K ARE ++A++ +EN + ++ ++ + K L +++ E
Sbjct: 838 ELLRKQE--EEAAKWAREEEEAQRRLEEN-RLRMEEEAARLRHEEEERKRKELEVQRQKE 894
Query: 1158 TAVSRLERREQLKK 1171
R +++E L++
Sbjct: 895 LMRQRQQQQEALRR 908
Score = 34.3 bits (77), Expect = 0.75
Identities = 56/272 (20%), Positives = 102/272 (37%), Gaps = 30/272 (11%)
Query: 216 DSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGE 275
D+EEE + L K K QK E++ ++ + + E E E +E +
Sbjct: 292 DAEEEMGTFDSSGAFLSLK-KVQKEPIPEEQEMDFRPVDEGEECSDSEGSHNEEAKEPDK 350
Query: 276 GQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRL 335
+ E E+ R + S E P + R + E + + + + E+ +
Sbjct: 351 TNKK--EGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKA 408
Query: 336 EEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGP----PEALEETGE 391
EE+ R+ E A+ R +E A+ + L Q ++ P P +
Sbjct: 409 EEETRM--------ENSLPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPVPNPSP 460
Query: 392 GRRGAEEEDLG----------EEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQ 441
R E +G ++EEG HLE Q +++ ++ D ERL + Q
Sbjct: 461 TLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQ---QAEKMVAYLQDSALDDERLASKLQ 517
Query: 442 REHSEEPGICEEQNPEAERRREQQGRSGDFQG 473
++ G+ EA ++ + G+ QG
Sbjct: 518 EHRAK--GVSIPLMHEAMQKWYYKDPQGEIQG 547
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 89.0 bits (219), Expect = 3e-17
Identities = 68/264 (25%), Positives = 137/264 (51%), Gaps = 14/264 (5%)
Query: 211 EPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELL 270
E N L + ++++E WR+ E K + Q+ + E +E +++ E ++W + +
Sbjct: 283 EENELWNLLNQQQEEKMWRQ-EEKIQEQEEKMCE----QELKIREQEEKMWRQEEKMHEQ 337
Query: 271 EEEGEGQEPPL---EAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQA 327
EE+ QE + E + +EE+ R E W E+ ++ + E EEE R + +
Sbjct: 338 EEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKI 397
Query: 328 QAEERRRLEEDARLEERRRQEEEEGR-CAEELKRQEEEEAEGWEELEQQEAEVQGPPEAL 386
+ +E +R E+ R E++ R+++E+ R EE+ RQEE+ E E ++ QE +++ E +
Sbjct: 398 REQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKM 457
Query: 387 EETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSE 446
+E E + EE+ +EE+ + + WR + +LL E+ E +E++ + ++ +
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQE--KLLKQEEKIWEQEEKMWRQEEKMWEQ 515
Query: 447 EPGICEEQNP---EAERRREQQGR 467
E + E++ + E+ REQ+ R
Sbjct: 516 EEKMQEQEEKMQRQEEKMREQEVR 539
Score = 86.7 bits (213), Expect = 1e-16
Identities = 119/527 (22%), Positives = 225/527 (42%), Gaps = 56/527 (10%)
Query: 13 IPDGGAESEQTVQAMSQ--DNILGKVKTLQQQLG-KNIKFGQRSPNAIPMNKANSGEAS- 68
+PD A + V + + D + K Q+++ KN F +R P + A
Sbjct: 110 LPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQK 169
Query: 69 ------LEEDLFLTSPMEIVTQQDIVLSDAENKSSDT-PSSLSPLNLPGAGSEMEEKVAP 121
LEE L + + T + + + + S + ++++ L +E++EK+
Sbjct: 170 RPENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLELYRNTITDEELKEKNAELQEKLRL 229
Query: 122 VKPSRPKRHFSSAGTIESVNLDAIPLAIARLDNSA---AKHKLAVKPKKQRVSKKHR--R 176
V+ + + + + + L +L A K +V K Q +++
Sbjct: 230 VESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWN 289
Query: 177 LAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCK 236
L Q E+ + +Q E + E+E EE+ QE+ RE E K
Sbjct: 290 LLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMW 349
Query: 237 RQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLE 296
RQ+ EK R +E++++ E ++W + + +E+ + QE + + EQ+ +
Sbjct: 350 RQE----EKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQ 405
Query: 297 APGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAE 356
W E++ RE+ E++ +EE E R+ E+ LEE + +EE+ R E
Sbjct: 406 EKMWRQ-EKKMREQDEKIREQEE----------EMWRQEEKIRELEEMMQDQEEKLREVE 454
Query: 357 ELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWR 416
E K QEEEE ++++QE ++Q E ++E E + +E+ L +EE+ + + WR
Sbjct: 455 E-KMQEEEE-----KMQEQEEKIQRQEEKIQEQ-EEKTWRQEKLLKQEEKIWEQEEKMWR 507
Query: 417 GQLSELLNDFEERLEDQERLKPEGQREHSEEPGI--------CEEQNPEAERRREQQGRS 468
+ E + + EE++++QE K + Q E E + +EQ + E+ G+
Sbjct: 508 QE--EKMWEQEEKMQEQEE-KMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKL 564
Query: 469 GDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQ 515
G Q A+ G + P L Q ++ +EA +L+Q
Sbjct: 565 G--QKAELLGGAGRESGSQRLPTL-----TPILQVELKSQEAQSLQQ 604
Score = 82.0 bits (201), Expect = 3e-15
Identities = 74/308 (24%), Positives = 151/308 (49%), Gaps = 17/308 (5%)
Query: 236 KRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSL 295
++Q A++ E Q + A + EEN LL ++ E + E + +EE+
Sbjct: 257 QQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQ 316
Query: 296 EAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCA 355
E E E+ R+E + E EE+ R + + +E + E++ ++ E QEE+ R
Sbjct: 317 ELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIRE---QEEKMWRQE 373
Query: 356 EELKRQEEEEAEGWEELEQQEAEVQGPPEALEET---GEGRRGAEEEDLGEEEEEGQAHL 412
E+++ Q+E+ E EE+ +QE +++ E +E E + ++E + E+EEE
Sbjct: 374 EKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQE 433
Query: 413 EDWRGQLSELLNDFEERL-EDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDF 471
E R +L E++ D EE+L E +E+++ E ++ +E I ++ E+ + +
Sbjct: 434 EKIR-ELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLL 492
Query: 472 QGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKV---------EEL 522
+ ++ +E++ E + +QE ++ + ++R+E EQ ++ +E+
Sbjct: 493 KQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEV 552
Query: 523 RWQEVDER 530
R QE++ER
Sbjct: 553 RLQELEER 560
Score = 63.5 bits (153), Expect = 1e-09
Identities = 71/296 (23%), Positives = 134/296 (45%), Gaps = 45/296 (15%)
Query: 248 LEEQRLQALERRLWEENR--RQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAER 305
LE R + L E+N +++L E E E L + R+ ++ L P ++
Sbjct: 204 LELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLP-----QQ 258
Query: 306 REREERERLEAEEERRRLQAQAQAEER-------RRLEEDARLEERRRQEEEEGRCAEEL 358
+ + E +RL E + + QAQ EE ++ EE +E + QE+EE C +EL
Sbjct: 259 QLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQEL 318
Query: 359 KRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLED-WRG 417
K +E+EE ++ +QE ++ E + E E + +EE + E+EE+ + E WR
Sbjct: 319 KIREQEE-----KMWRQEEKMHEQEEKIREQ-EDKMWRQEEKIREQEEKIREQEEKMWRQ 372
Query: 418 QLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRP 477
+ E + + +E++++QE EE + E+ REQ+ + ++
Sbjct: 373 E--EKIREQDEKIQEQE-----------------EEMWRQEEKIREQEEKR-----QEKM 408
Query: 478 GPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQTM 533
+EK+ E + +QE + + + E +Q K+ E+ + +E + M
Sbjct: 409 WRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKM 464
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 89.0 bits (219), Expect = 3e-17
Identities = 68/264 (25%), Positives = 137/264 (51%), Gaps = 14/264 (5%)
Query: 211 EPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELL 270
E N L + ++++E WR+ E K + Q+ + E +E +++ E ++W + +
Sbjct: 283 EENELWNLLNQQQEEKMWRQ-EEKIQEQEEKMCE----QELKIREQEEKMWRQEEKMHEQ 337
Query: 271 EEEGEGQEPPL---EAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQA 327
EE+ QE + E + +EE+ R E W E+ ++ + E EEE R + +
Sbjct: 338 EEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKI 397
Query: 328 QAEERRRLEEDARLEERRRQEEEEGR-CAEELKRQEEEEAEGWEELEQQEAEVQGPPEAL 386
+ +E +R E+ R E++ R+++E+ R EE+ RQEE+ E E ++ QE +++ E +
Sbjct: 398 REQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKM 457
Query: 387 EETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSE 446
+E E + EE+ +EE+ + + WR + +LL E+ E +E++ + ++ +
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQE--KLLKQEEKIWEQEEKMWRQEEKMWEQ 515
Query: 447 EPGICEEQNP---EAERRREQQGR 467
E + E++ + E+ REQ+ R
Sbjct: 516 EEKMQEQEEKMQRQEEKMREQEVR 539
Score = 86.3 bits (212), Expect = 2e-16
Identities = 109/482 (22%), Positives = 209/482 (43%), Gaps = 50/482 (10%)
Query: 47 IKFGQRSPNAIPMNKANSGEASLEEDLFLTSPMEIVTQQDIVLSDAENKSSDTPSSLSPL 106
++ G+ + P N + + + + +E +T++ LS +++ T L
Sbjct: 160 LRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRNTITDEELKEK 219
Query: 107 NLPGAGSEMEEKVAPVKPSRPKRHFSSAGTIESVNLDAIPLAIARLDNSA---AKHKLAV 163
N +E++EK+ V+ + + + + + L +L A K +V
Sbjct: 220 N-----AELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSV 274
Query: 164 KPKKQRVSKKHR--RLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEER 221
K Q +++ L Q E+ + +Q E + E+E EE+
Sbjct: 275 SAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKM 334
Query: 222 RRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPL 281
QE+ RE E K RQ+ EK R +E++++ E ++W + + +E+ + QE +
Sbjct: 335 HEQEEKIREQEDKMWRQE----EKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEM 390
Query: 282 EAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARL 341
+ EQ+ + W E++ RE+ E++ +EE E R+ E+ L
Sbjct: 391 WRQEEKIREQEEKRQEKMWRQ-EKKMREQDEKIREQEE----------EMWRQEEKIREL 439
Query: 342 EERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDL 401
EE + +EE+ R EE K QEEEE ++++QE ++Q E ++E E + +E+ L
Sbjct: 440 EEMMQDQEEKLREVEE-KMQEEEE-----KMQEQEEKIQRQEEKIQEQ-EEKTWRQEKLL 492
Query: 402 GEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGI--------CEE 453
+EE+ + + WR + E + + EE++++QE K + Q E E + +E
Sbjct: 493 KQEEKIWEQEEKMWRQE--EKMWEQEEKMQEQEE-KMQRQEEKMREQEVRLWQQEEKMQE 549
Query: 454 QNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAAL 513
Q + E+ G+ G Q A+ G + P L Q ++ +EA +L
Sbjct: 550 QEVRLQELEERLGKLG--QKAELLGGAGRESGSQRLPTL-----TPILQVELKSQEAQSL 602
Query: 514 EQ 515
+Q
Sbjct: 603 QQ 604
Score = 82.0 bits (201), Expect = 3e-15
Identities = 74/308 (24%), Positives = 151/308 (49%), Gaps = 17/308 (5%)
Query: 236 KRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSL 295
++Q A++ E Q + A + EEN LL ++ E + E + +EE+
Sbjct: 257 QQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQ 316
Query: 296 EAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCA 355
E E E+ R+E + E EE+ R + + +E + E++ ++ E QEE+ R
Sbjct: 317 ELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIRE---QEEKMWRQE 373
Query: 356 EELKRQEEEEAEGWEELEQQEAEVQGPPEALEET---GEGRRGAEEEDLGEEEEEGQAHL 412
E+++ Q+E+ E EE+ +QE +++ E +E E + ++E + E+EEE
Sbjct: 374 EKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQE 433
Query: 413 EDWRGQLSELLNDFEERL-EDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDF 471
E R +L E++ D EE+L E +E+++ E ++ +E I ++ E+ + +
Sbjct: 434 EKIR-ELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLL 492
Query: 472 QGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKV---------EEL 522
+ ++ +E++ E + +QE ++ + ++R+E EQ ++ +E+
Sbjct: 493 KQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEV 552
Query: 523 RWQEVDER 530
R QE++ER
Sbjct: 553 RLQELEER 560
Score = 63.5 bits (153), Expect = 1e-09
Identities = 71/296 (23%), Positives = 134/296 (45%), Gaps = 45/296 (15%)
Query: 248 LEEQRLQALERRLWEENR--RQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAER 305
LE R + L E+N +++L E E E L + R+ ++ L P ++
Sbjct: 204 LELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLP-----QQ 258
Query: 306 REREERERLEAEEERRRLQAQAQAEER-------RRLEEDARLEERRRQEEEEGRCAEEL 358
+ + E +RL E + + QAQ EE ++ EE +E + QE+EE C +EL
Sbjct: 259 QLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQEL 318
Query: 359 KRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLED-WRG 417
K +E+EE ++ +QE ++ E + E E + +EE + E+EE+ + E WR
Sbjct: 319 KIREQEE-----KMWRQEEKMHEQEEKIREQ-EDKMWRQEEKIREQEEKIREQEEKMWRQ 372
Query: 418 QLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRP 477
+ E + + +E++++QE EE + E+ REQ+ + ++
Sbjct: 373 E--EKIREQDEKIQEQE-----------------EEMWRQEEKIREQEEKR-----QEKM 408
Query: 478 GPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQTM 533
+EK+ E + +QE + + + E +Q K+ E+ + +E + M
Sbjct: 409 WRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKM 464
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 86.7 bits (213), Expect = 1e-16
Identities = 91/382 (23%), Positives = 160/382 (41%), Gaps = 54/382 (14%)
Query: 201 GEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRL 260
GE+ + + P + +E+ ++D R+ + + + AE + R++E+ ER
Sbjct: 43 GEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEK-----ER-- 95
Query: 261 WEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEER 320
E RR+ EE+ + + E ER R E R + RRER+ E+LE + ER
Sbjct: 96 -EHERRKRHREEQDKARR---EWERQKRREMAR--------EHSRRERDRLEQLERKRER 143
Query: 321 RRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQ 380
R + Q E+R + E + R EERR++ E + + E+ ++ + + +
Sbjct: 144 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 203
Query: 381 GPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEG 440
PP E G+GR+ +EE + E +LL+D ++ + D ER K
Sbjct: 204 -PPRERFELGDGRKPVKEEKMEER----------------DLLSDLQD-ISDSER-KTSS 244
Query: 441 QREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEA 500
S E G E+ E E E++G + + + EE+ EE + E E E
Sbjct: 245 AESSSAESGSGSEEEEEEEEEEEEEGSTSE----ESEEEEEEEEEEEEETGSNSEEASEQ 300
Query: 501 AQPPVERKEAAALEQGRKVEELRWQEVDERQTMPRPYTFQVSSGGKQILFPKVNLSPVTP 560
+ V +E + E+ +E + + F SG + +V TP
Sbjct: 301 SAEEVSEEEMSEDEE---------RENENHLLVVPESRFDRDSGESEEAEEEVGEG--TP 349
Query: 561 AKDTGLTAAPQEPKAPKASPVQ 582
+ + LT P +P SP++
Sbjct: 350 -QSSALTEGDYVPDSPALSPIE 370
Score = 72.8 bits (177), Expect = 2e-12
Identities = 78/314 (24%), Positives = 133/314 (42%), Gaps = 31/314 (9%)
Query: 153 DNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPG-EDKPTWHEEE 211
D LA+KP +Q K+ +D + ++ + H ++K HE
Sbjct: 41 DRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERR 100
Query: 212 PNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEE-QRLQALERRLWEENRRQ-EL 269
+ +++ RR+ W + + ++ E+ RLE+ +R + ER++ E+ + Q E
Sbjct: 101 KRHREEQDKARRE---WERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQ 157
Query: 270 LEEEGEGQEPPLEAE---------RAPREEQQRSLEAPGWEDAERREREERERLEAEEER 320
E E +E E E R RE+ ++A W + R RER E + R
Sbjct: 158 KERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW--SRSPPRPPRERFELGDGR 215
Query: 321 RRLQAQAQAEERRRLEEDARLEERRRQ-------EEEEGRCAEELKRQEEEEAEGWEELE 373
+ ++ + + EER L + + + R+ E G +EE + +EEEE E E
Sbjct: 216 KPVK-EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE 274
Query: 374 QQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQ 433
+ E E + E EETG A E+ E EE + E+ R + LL E R +
Sbjct: 275 ESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEE-RENENHLLVVPESRFD-- 331
Query: 434 ERLKPEGQREHSEE 447
+ G+ E +EE
Sbjct: 332 ---RDSGESEEAEE 342
Score = 33.5 bits (75), Expect = 1.3
Identities = 44/220 (20%), Positives = 91/220 (41%), Gaps = 16/220 (7%)
Query: 982 RPYLVELLSRRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATER--- 1038
R + +E+ R + + E E+ +S +PP +E+ ++DE+ + R
Sbjct: 20 RDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRS 79
Query: 1039 KPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTE------KVETAQPLWITL 1092
A A +EK + R + ++R + K E + E + +
Sbjct: 80 HSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLER 139
Query: 1093 ALQKQKGFREQQATREERKQAR---EAKQAEKLSKENVSV---SVQPGSSSVSRAGSLHK 1146
++++ REQQ + E+K+ E ++ E+ ++ VS +++ S +A +
Sbjct: 140 KRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSR 199
Query: 1147 STALPEEKRPETAVSRLERREQLKKANTLPTSVTVEISDS 1186
S P +R E R +E+ + L + + +ISDS
Sbjct: 200 SPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQ-DISDS 238
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 86.7 bits (213), Expect = 1e-16
Identities = 91/382 (23%), Positives = 160/382 (41%), Gaps = 54/382 (14%)
Query: 201 GEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRL 260
GE+ + + P + +E+ ++D R+ + + + AE + R++E+ ER
Sbjct: 77 GEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEK-----ER-- 129
Query: 261 WEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEER 320
E RR+ EE+ + + E ER R E R + RRER+ E+LE + ER
Sbjct: 130 -EHERRKRHREEQDKARR---EWERQKRREMAR--------EHSRRERDRLEQLERKRER 177
Query: 321 RRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQ 380
R + Q E+R + E + R EERR++ E + + E+ ++ + + +
Sbjct: 178 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 237
Query: 381 GPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEG 440
PP E G+GR+ +EE + E +LL+D ++ + D ER K
Sbjct: 238 -PPRERFELGDGRKPVKEEKMEER----------------DLLSDLQD-ISDSER-KTSS 278
Query: 441 QREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEA 500
S E G E+ E E E++G + + + EE+ EE + E E E
Sbjct: 279 AESSSAESGSGSEEEEEEEEEEEEEGSTSE----ESEEEEEEEEEEEEETGSNSEEASEQ 334
Query: 501 AQPPVERKEAAALEQGRKVEELRWQEVDERQTMPRPYTFQVSSGGKQILFPKVNLSPVTP 560
+ V +E + E+ +E + + F SG + +V TP
Sbjct: 335 SAEEVSEEEMSEDEE---------RENENHLLVVPESRFDRDSGESEEAEEEVGEG--TP 383
Query: 561 AKDTGLTAAPQEPKAPKASPVQ 582
+ + LT P +P SP++
Sbjct: 384 -QSSALTEGDYVPDSPALSPIE 404
Score = 72.8 bits (177), Expect = 2e-12
Identities = 78/314 (24%), Positives = 133/314 (42%), Gaps = 31/314 (9%)
Query: 153 DNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPG-EDKPTWHEEE 211
D LA+KP +Q K+ +D + ++ + H ++K HE
Sbjct: 75 DRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERR 134
Query: 212 PNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEE-QRLQALERRLWEENRRQ-EL 269
+ +++ RR+ W + + ++ E+ RLE+ +R + ER++ E+ + Q E
Sbjct: 135 KRHREEQDKARRE---WERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQ 191
Query: 270 LEEEGEGQEPPLEAE---------RAPREEQQRSLEAPGWEDAERREREERERLEAEEER 320
E E +E E E R RE+ ++A W + R RER E + R
Sbjct: 192 KERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW--SRSPPRPPRERFELGDGR 249
Query: 321 RRLQAQAQAEERRRLEEDARLEERRRQ-------EEEEGRCAEELKRQEEEEAEGWEELE 373
+ ++ + + EER L + + + R+ E G +EE + +EEEE E E
Sbjct: 250 KPVK-EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE 308
Query: 374 QQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQ 433
+ E E + E EETG A E+ E EE + E+ R + LL E R +
Sbjct: 309 ESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEE-RENENHLLVVPESRFD-- 365
Query: 434 ERLKPEGQREHSEE 447
+ G+ E +EE
Sbjct: 366 ---RDSGESEEAEE 376
Score = 33.5 bits (75), Expect = 1.3
Identities = 44/220 (20%), Positives = 91/220 (41%), Gaps = 16/220 (7%)
Query: 982 RPYLVELLSRRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATER--- 1038
R + +E+ R + + E E+ +S +PP +E+ ++DE+ + R
Sbjct: 54 RDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRS 113
Query: 1039 KPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTE------KVETAQPLWITL 1092
A A +EK + R + ++R + K E + E + +
Sbjct: 114 HSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLER 173
Query: 1093 ALQKQKGFREQQATREERKQAR---EAKQAEKLSKENVSV---SVQPGSSSVSRAGSLHK 1146
++++ REQQ + E+K+ E ++ E+ ++ VS +++ S +A +
Sbjct: 174 KRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSR 233
Query: 1147 STALPEEKRPETAVSRLERREQLKKANTLPTSVTVEISDS 1186
S P +R E R +E+ + L + + +ISDS
Sbjct: 234 SPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQ-DISDS 272
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 86.3 bits (212), Expect = 2e-16
Identities = 133/573 (23%), Positives = 219/573 (38%), Gaps = 78/573 (13%)
Query: 153 DNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEP 212
+ SA + + + +S++ Q HE L+ + PG+ E P
Sbjct: 1780 ETSAGSELGEAEQEGEGISERGETGGQGSGHEDN-LQGEAAAGGDQDPGQSDGAEGIEAP 1838
Query: 213 NPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEE 272
++E E + + + EA+ Q+AE + E+ E E+ E E
Sbjct: 1839 ---EAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEA 1895
Query: 273 EGEGQEPPLEAERAPREEQQ-----RSLEAPGWEDAERREREERERLEAEEERRRLQAQA 327
E E Q P E AP E++ S+EA E + E E E EAEE + + Q
Sbjct: 1896 EWEVQ-PESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQT 1954
Query: 328 QAE----ERRRLEEDAR--------LEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQ 375
Q E E + EE+A+ LE +E EG E + E EAEG E Q
Sbjct: 1955 QPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEG----EMQ 2010
Query: 376 EAEVQGPPE--------------ALEETGEGRR---GAEEEDLGEEEEEGQAHLEDWRGQ 418
EAE + PE A E GE ++ A+ E G E E + ++ G+
Sbjct: 2011 EAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGE 2070
Query: 419 LSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRP- 477
+ E + ED + + EG+ + E G+ E E E ++ + + + +G +P
Sbjct: 2071 VQEAEGEAHPESEDVDAQEAEGEAQ-PESEGV-EAPEAEGEAQKAEGIEAPETEGEAQPE 2128
Query: 478 --GPEEKREEGDTEPLLKQEGPVEA------AQPPVERKEAAALEQGRKVEELRWQEVDE 529
G E EG+ +P + EG VEA AQP E EA E+ + EL E E
Sbjct: 2129 SEGIEAPEAEGEAQP--ESEG-VEAQDAEGEAQPESEGIEAQEAEEEAQ-PELEGVEAPE 2184
Query: 530 RQTMPRPYTFQVSSGGKQILFPKVNLSPVTPAKDTGLTAAPQEPKAPKASPVQHALPSSL 589
+ +P + + + + P + +E P+ V+
Sbjct: 2185 AEGEAQPESEGIEAPEAE--------GEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGE 2236
Query: 590 SVPHTAILVTGAQLCGPAVNLSQIKDTACKSLLGLEEKKHAEAPAGENPPRGPGDARAGS 649
+ P + G + P V+L + EE + +P E+ P P +
Sbjct: 2237 AQPESEGETQGEKKGSPQVSLGDGQS---------EEASESSSPVPEDRPTPPPSPGGDT 2287
Query: 650 GKAKPRQESPSSASALAEWASIRSRILKNAESD 682
+P ++ S+S + W + K++E+D
Sbjct: 2288 PHQRPGSQTGPSSSRASSWGNCWQ---KDSEND 2317
Score = 62.0 bits (149), Expect = 3e-09
Identities = 227/1123 (20%), Positives = 372/1123 (33%), Gaps = 164/1123 (14%)
Query: 14 PDGGAESEQTVQAMSQDNILGKVKTLQQQLGK-NIKFGQRSPNAIPMNKANSGEASLEED 72
P+GG + E + + ++ + + Q+L + + G+ S P+ + +G AS +
Sbjct: 1381 PEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAE 1440
Query: 73 LFLTSPMEIVTQQDIVLSDAENKSSD--TPSSLSP-LNLPGAGSEMEEKVAPVKPSRPKR 129
E T+ LS+ + +S+ + S L P L P + M ++ +P++
Sbjct: 1441 PCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAA 1500
Query: 130 HFSSAGTIESVNLDAIPLAIARLDNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLE 189
SS+ S LD P+ ++ L K LA H A + GL+
Sbjct: 1501 ERSSSVAC-SAALDCDPIWVSVLLKKTEKAFLA-----------HLASAVAELRARWGLQ 1548
Query: 190 SRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELE---AKCKRQKAEAAEKR 246
LDQ L + +R Q+ REL+ + R E +
Sbjct: 1549 DNDLLDQMAAE--------------LQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREA 1594
Query: 247 RLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERR 306
E LQ +RR R E PL +L + E+AE
Sbjct: 1595 LTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGE 1654
Query: 307 EREERERLEAEEERRRLQAQAQAEERRRLEEDARLEE---RRRQEEEEGRCAEELKRQEE 363
E E ++ R ++E L++ R+R E +G AE +
Sbjct: 1655 EFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTH 1714
Query: 364 EEAEGWEELEQQEAEV-----QGPPEALEETGEG-RRGAEEEDLGEEEEEGQAHLEDWRG 417
+ ++ E + QGP E GEG +R ++D E EG A ++ G
Sbjct: 1715 TDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREG 1774
Query: 418 QLSELLNDFEERLEDQERLKPEGQREHSEE--PGICEEQNPEAERRREQQGRSGDFQGAD 475
+ L + E+ + EG E E G E N + E G GA+
Sbjct: 1775 KTHNSETSAGSELGEAEQ-EGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAE 1833
Query: 476 RPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQTMPR 535
G E EG+ +P + EG VEA + + +EA +G E E E + +
Sbjct: 1834 --GIEAPEAEGEAQP--ESEG-VEAPEAEGDAQEA----EGEAQPESEDVEAPEAEGEAQ 1884
Query: 536 PYTFQVSSGGKQILFPKVNLSPVTPAKDTGLTAAPQEPKAPKASPVQHALPSSLSVPHTA 595
P + V TP + + + +AP+A + A P + SV A
Sbjct: 1885 PESEDVE----------------TPEAEWEVQPESEGAEAPEAE--KEAQPETESVE--A 1924
Query: 596 ILVTGAQLCGPAVNLSQIKDTACKSLLGLEEKKHAEAPAGENPPRGPGDARAGSGKAKPR 655
+ G E + AEA E A+ G+ +P
Sbjct: 1925 LETEGEDE---------------------PESEGAEAQEAEEA------AQEAEGQTQPE 1957
Query: 656 QESPSSASALAEWASIRSRILKNAESDPRSSERD---QLRPGDESTPRGRCDSRGNQRKT 712
E S A E A S ++ E + + E + Q D P + + + +
Sbjct: 1958 SEVIESQEAEEE-AQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEA 2016
Query: 713 PPVNAKFSIMPAWQKFSDGGTETSKQSTEAESIRKRPMLGPSEETAPQPPPAGVRELGKG 772
P + P + E Q TE ++ QP GV
Sbjct: 2017 QPESDGVEAQPKSEGEEAQEVEGETQKTEGDA---------------QPESDGVEAPEAE 2061
Query: 773 PEKSEMHREPADTT-EGCKFAKDLPSFLVPSLPYPPQKVVAHTEFTTSSDSETANGIAKP 831
E E E + E ++D+ + P + V E +++ A GI P
Sbjct: 2062 EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPE--AEGEAQKAEGIEAP 2119
Query: 832 DPVMPGGEEKASPFGIKLRRTNYSLRFNCDQQAEQKKKKRHSSTGDSADAGPPAAGSARG 891
+ GE + GI+ + Q E + + + G+ A P + G
Sbjct: 2120 ETE---GEAQPESEGIEAPEAEG------EAQPESEGVEAQDAEGE---AQPESEGIEAQ 2167
Query: 892 EKEMEGVALKHGPSLPQERKQA-PSTRRDSAEPSSSRSVPVAHPGPPPASSQTPAPEHDK 950
E E E G P+ +A P + A + + P P + + PE +
Sbjct: 2168 EAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEG 2227
Query: 951 AANKMPLAQKPALAPKPTSQTPPASPLSKLSRPYLVELLSRRAGRPDPEPSEPSKEDQES 1010
+ + T SP L E + P+ P+ P ++
Sbjct: 2228 VETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDT 2287
Query: 1011 SDRRPPSPPGPEERKGQ------KRDEEEEATERKPASPPLPAT---------------- 1048
+RP S GP + ++D E + SP +T
Sbjct: 2288 PHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPES 2347
Query: 1049 ----QQEKP--SQTPEAGRKEKPMLQSRHSLDGSKLTEKVETA 1085
Q+E P S+TPE G E LQ +L TE V A
Sbjct: 2348 STSEQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAVGRA 2390
Score = 53.9 bits (128), Expect = 9e-07
Identities = 66/243 (27%), Positives = 107/243 (44%), Gaps = 15/243 (6%)
Query: 235 CKRQKAEAAEKRRLEEQRLQALERRLWEENRRQEL-LEEEGEGQEPPLEAERAPREEQQR 293
C + EA +R EEQR + +L E ++E+ LEE EG E E A + E+ +
Sbjct: 1269 CATNEDEA--ERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETK 1326
Query: 294 SLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGR 353
+ E E + E +E E +EE +L+ + EE +LEE ++ E G
Sbjct: 1327 TEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEE-VKEGPEGGL 1385
Query: 354 CAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQ--AH 411
E L+ +EE +E V G E E + +G++E+D +EEE G+ A
Sbjct: 1386 QGEALEEGLKEEG------LPEEGSVHG-QELSEASSPDGKGSQEDDPVQEEEAGRASAS 1438
Query: 412 LEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDF 471
E + +E + L + + E Q EPG+ E+ P A ++ ++
Sbjct: 1439 AEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGL--EKPPGATMMGQEHTQAQPT 1496
Query: 472 QGA 474
QGA
Sbjct: 1497 QGA 1499
Score = 44.3 bits (103), Expect = 7e-04
Identities = 77/320 (24%), Positives = 119/320 (37%), Gaps = 40/320 (12%)
Query: 108 LPGAGSE-MEEKVAPVKPSRPKRHFSSAGTIESVNLDAIPLAIARLDNSAAKH--KLAVK 164
LP GS M E P S S G+ ES ++P A +D + +L +K
Sbjct: 1181 LPDLGSHAMTENFTPTSSSGVDISSGSGGSGES----SVPCA---MDGTLVTQGTELPLK 1233
Query: 165 PKKQRVSKKHRRLAQDPQHEQGG-----LESRPCLDQNGHPGEDKPTWHEEEPNPLDSEE 219
QR + D +++Q L +R C ++ + + + L+
Sbjct: 1234 TSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLA 1293
Query: 220 ERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERR----LWEEN-RRQELLEEEG 274
E QE+ E + E E L+E+ +Q E + L EE + +E E EG
Sbjct: 1294 ENTVQEEVQLE-------ETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEG 1346
Query: 275 EGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRR 334
EGQ+ E Q +E G E + EE +LE +E Q +A E
Sbjct: 1347 EGQQ--------EEEAQLEEIEETGGEGLQ----EEGVQLEEVKEGPEGGLQGEALEEGL 1394
Query: 335 LEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQG-PPEALEETGEGR 393
EE E +E + + K +E++ EE + A + P E EE E
Sbjct: 1395 KEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPP 1454
Query: 394 RGAEEEDLGEEEEEGQAHLE 413
E D E + + LE
Sbjct: 1455 SHLSETDPSASERQSGSQLE 1474
Score = 40.0 bits (92), Expect = 0.014
Identities = 69/304 (22%), Positives = 115/304 (37%), Gaps = 39/304 (12%)
Query: 874 STGDSADAGPPAAGSARGEKE------MEGVALK-HGPSLPQ-ERKQAPSTRRDSAEPSS 925
S G P A G A+ E E EG A + G + P+ E +AP ++ S
Sbjct: 1829 SDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESE 1888
Query: 926 SRSVPVAHPGPPPASSQTPAPEHDKAA---NKMPLAQKPALAPKPTSQTPPASPLSKL-- 980
P A P S APE +K A + A + +P S+ A +
Sbjct: 1889 DVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQ 1948
Query: 981 -----SRPYLVELLSRRA---GRPDPEPSEPSKEDQESSDRRPPSPPGPE-----ERKGQ 1027
++P + S+ A +P+ E E + + E+ + + P E E +G+
Sbjct: 1949 EAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGE 2008
Query: 1028 KRDEEEEA------TERKPASPPLPA------TQQEKPSQTPEAGRKEKPMLQSRHSLDG 1075
++ EEEA E +P S A TQ+ + PE+ E P +
Sbjct: 2009 MQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAE 2068
Query: 1076 SKLTEKVETAQPLWITLALQKQKGFREQQATREERKQAR-EAKQAEKLSKENVSVSVQPG 1134
++ E A P + Q+ +G + ++ E +A EA++AE + QP
Sbjct: 2069 GEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPE 2128
Query: 1135 SSSV 1138
S +
Sbjct: 2129 SEGI 2132
Score = 34.7 bits (78), Expect = 0.58
Identities = 57/253 (22%), Positives = 90/253 (35%), Gaps = 44/253 (17%)
Query: 451 CEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEG-PVEAAQPPVERKE 509
C EAER E+Q S + + +E+ + +T+ + EG EA Q + E
Sbjct: 1269 CATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTE 1328
Query: 510 AAALEQGRKVEELRWQEVDERQTMPRPYTFQVSSGGKQILFPKVNLSPVTPAKDTGLTAA 569
E+G ++EE + E + +Q +GG+ + V L V + GL
Sbjct: 1329 EGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGL--- 1385
Query: 570 PQEPKAPKASPVQHALPSSLSVPHTAILVTGAQLCGPAVNLSQIKDTACKSLLGLEEKKH 629
+ +A + + LP SV +E
Sbjct: 1386 --QGEALEEGLKEEGLPEEGSVHG-------------------------------QELSE 1412
Query: 630 AEAPAGENPPRGPGDARAGSGKAKPRQESPSSASALAEWASIRSRILKNAESDPRSSER- 688
A +P G+ +G+A E P A E S + +E+DP +SER
Sbjct: 1413 ASSPDGKGSQEDDPVQEEEAGRASASAE-PCPAEGTEEPTEPPSHL---SETDPSASERQ 1468
Query: 689 --DQLRPGDESTP 699
QL PG E P
Sbjct: 1469 SGSQLEPGLEKPP 1481
Score = 30.8 bits (68), Expect = 8.3
Identities = 32/141 (22%), Positives = 51/141 (36%), Gaps = 15/141 (10%)
Query: 983 PYLVELLSRRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPAS 1042
P E R + +P P+E ++E E + P ER Q + E E+ P +
Sbjct: 1426 PVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASER--QSGSQLEPGLEKPPGA 1483
Query: 1043 PPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQK-QKGFR 1101
+ QE P G E+ S P+W+++ L+K +K F
Sbjct: 1484 TMM---GQEHTQAQPTQGAAER---------SSSVACSAALDCDPIWVSVLLKKTEKAFL 1531
Query: 1102 EQQATREERKQAREAKQAEKL 1122
A+ +AR Q L
Sbjct: 1532 AHLASAVAELRARWGLQDNDL 1552
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 85.9 bits (211), Expect = 2e-16
Identities = 78/269 (28%), Positives = 136/269 (50%), Gaps = 26/269 (9%)
Query: 218 EEERRRQEDYWRELEAK-CKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEG 276
E+ER+R E+ R+ EA+ +RQK E ++RRLEE +L+ E RL + + +E +E+ E
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKR-EERLRKVLQARERVEQMKEE 594
Query: 277 QEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQA-------QA 329
++ +E + A +E+ + + + +++ +++E E RR+ + +A Q
Sbjct: 595 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 654
Query: 330 EERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEET 389
EE RR +E L++++ +E+E R A E KR E+ + E E++E E + +E
Sbjct: 655 EEERRHQE--LLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 712
Query: 390 GEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPG 449
E R E++ E+E QA E +ER E RL+ E + EE
Sbjct: 713 REQERQLAEQERRREQERLQAERE------------LQER-EKALRLQKEQLQRELEEKK 759
Query: 450 ICEEQNPEAER--RREQQGRSGDFQGADR 476
EEQ AER + EQ+ ++ + GA +
Sbjct: 760 KKEEQQRLAERQLQEEQEKKAKEAAGASK 788
Score = 81.6 bits (200), Expect = 4e-15
Identities = 79/261 (30%), Positives = 133/261 (50%), Gaps = 30/261 (11%)
Query: 151 RLDNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHEQGG-----LESRPCLDQNGHPGEDKP 205
RL+N K + A + ++Q+V + RR ++ + ++ L++R ++Q E+K
Sbjct: 541 RLENLRRKEE-AEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK---EEKK 596
Query: 206 TWHEEEPNPLDSEEERRRQEDYWRE-LEAKCKRQKAEAAEKRRLEEQRLQALE--RRLWE 262
E++ +D + E+ ++E E + K +K E E RR +E+ + L ++ E
Sbjct: 597 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 656
Query: 263 ENRRQELLEEEGEGQEPPL-EAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERR 321
E R QELL+++ E ++ L +A A R +QR E + ERRE+E RE+ E+ERR
Sbjct: 657 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER---REQERREQERREQERREQERR 713
Query: 322 RLQAQAQAEERRRLEEDARLEERRRQEEEEG---------RCAEELKRQEEE----EAEG 368
+ Q AE+ RR E++ ER QE E+ R EE K++EE+ E +
Sbjct: 714 EQERQL-AEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQL 772
Query: 369 WEELEQQEAEVQGPPEALEET 389
EE E++ E G +AL T
Sbjct: 773 QEEQEKKAKEAAGASKALNVT 793
Score = 75.5 bits (184), Expect = 3e-13
Identities = 73/227 (32%), Positives = 115/227 (50%), Gaps = 33/227 (14%)
Query: 173 KHRRLAQDPQHEQGGLESRPCLDQNGHPGED--KPTWHEEEPNPLDSEEERRRQEDYWRE 230
K RLA++ ++ + ++ E+ + W ++E EEERR QE ++
Sbjct: 614 KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE------EEERRHQELLQKK 667
Query: 231 LEAKCKRQKAEAAEKRRLEEQRLQAL--ERRLWEENRRQELLEEEGEGQEPPLEAERAPR 288
E + +R + +AAE +RL EQR Q + R +E R QE E+E QE L AE+ R
Sbjct: 668 KEEEQERLR-KAAEAKRLAEQREQERREQERREQERREQERREQERREQERQL-AEQERR 725
Query: 289 EEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQE 348
EQ+R L+A + E +ERE+ RL+ E Q Q + EE+++ EE RL ER+ QE
Sbjct: 726 REQER-LQA----ERELQEREKALRLQKE------QLQRELEEKKKKEEQQRLAERQLQE 774
Query: 349 EEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPP-EALEETGEGRR 394
E+E ++ +EA G + +VQ P + + T +G R
Sbjct: 775 EQE---------KKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHR 812
Score = 67.0 bits (162), Expect = 1e-10
Identities = 67/245 (27%), Positives = 120/245 (48%), Gaps = 36/245 (14%)
Query: 306 REREERERLEAEEERRRLQAQAQAEERRRLEEDARL--EERRRQEEEEGRCAEELKRQEE 363
+ER+ E L +EE +L+ Q E++RR E+ +L EER R+ + E++K +++
Sbjct: 537 KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKK 596
Query: 364 EEAE-------------GWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLG----EEEE 406
++ E E L +++A+ + + +EE E RR EEE ++EE
Sbjct: 597 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV-EARRKQEEEARRLRWLQQEE 655
Query: 407 EGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQG 466
E + H ELL +E E+QERL+ + + E EQ + RREQ+
Sbjct: 656 EERRH--------QELLQKKKE--EEQERLRKAAEAKRLAEQ---REQERREQERREQER 702
Query: 467 RSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQE 526
R + + +R E++R+ + E +QE ++A + ER++A L++ + EL ++
Sbjct: 703 REQERREQER--REQERQLAEQERRREQE-RLQAERELQEREKALRLQKEQLQRELEEKK 759
Query: 527 VDERQ 531
E Q
Sbjct: 760 KKEEQ 764
Score = 45.1 bits (105), Expect = 4e-04
Identities = 114/549 (20%), Positives = 198/549 (36%), Gaps = 71/549 (12%)
Query: 642 PGDARAGSGKAKPRQESPSSASALAEWASIRSRILKNAESDPRSSERDQLRPGDESTPRG 701
P +R S + +PSS S A S + K R+S R + +E G
Sbjct: 293 PTGSRTDSQSVRHSPIAPSSPSPQV-LAQKYSLVAKQESVVRRASRRLAKKTAEEPAASG 351
Query: 702 R--CDSR-------------GNQRKTPPVNAKFSIMPAWQKFSDGGTETSKQSTEAESIR 746
R C S G+++K PP A+ + A + + S + E
Sbjct: 352 RIICHSYLERLLNVEVPQKVGSEQKEPPEEAE-PVAAAEPEVPENNGNNSWPHNDTEIAN 410
Query: 747 KRPMLGPSEETAPQPPPAGVRELGKGPEKSEMHREPADTTEGCKFAKDLPSFL------- 799
P P+ ++P+ P AG +E ++++ REP + + K S L
Sbjct: 411 STPNPKPAA-SSPETPSAGQQEAKT--DQADGPREPPQSARRKRSYKQAVSELDEEQHLE 467
Query: 800 ----------VPSLPYPPQKVVAHTE---FTTSSDSETANGIAKPDPVMPGGEEKASPFG 846
PS P P KVV T + + P VM ++ +P
Sbjct: 468 DEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTP-- 525
Query: 847 IKLRRTNYSLRFNCDQQAEQKKKKRHSSTGDSADAGPPAAGSARGEKE--MEGVALKHGP 904
LR + +K+++R + +A +K +E V LK
Sbjct: 526 ---------LRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKR-- 574
Query: 905 SLPQERKQAPSTRRDSAEPSSSRSVPVAHPGPPPASSQTPAPEHDKAANKMPLAQKPALA 964
+ER + R+ E +T + ++ A + A+K A A
Sbjct: 575 ---EERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEK--AKKKAAA 629
Query: 965 PKPTSQTPPASPLSKLSRPYLVELLSRRAGRPDPEPSEPSKEDQESSDRRPPSPPG-PEE 1023
K + R L L R E + KE+++ R+ E+
Sbjct: 630 KKMEEVEARRKQEEEARR--LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQ 687
Query: 1024 RKGQKRDEEEEATERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVE 1083
R+ ++R++E ER+ ++++ + R+E+ LQ+ L + EK
Sbjct: 688 REQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAEREL---QEREKAL 744
Query: 1084 TAQPLWITLALQKQKGFREQQATRE---ERKQAREAKQAEKLSKE-NVSVSVQ-PGSSSV 1138
Q + L+++K EQQ E + +Q ++AK+A SK NV+V VQ P +S
Sbjct: 745 RLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSY 804
Query: 1139 SRAGSLHKS 1147
H++
Sbjct: 805 QMTPQGHRA 813
Score = 39.7 bits (91), Expect = 0.018
Identities = 98/480 (20%), Positives = 167/480 (34%), Gaps = 72/480 (15%)
Query: 729 SDGGTETSKQSTEAESIRKRPMLGPSEETAPQPPPAGVRELGKGPEKSEMHREPADTTEG 788
S G + ++ST +S K +L ++ P + G G +S A + G
Sbjct: 208 SQGIPTSDEESTPKKS--KARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPG 265
Query: 789 CKFAKDLPSFLVPSLPYPPQKV--VAHTEFTTSSDSETANGIAKPDPVMPGGEEKASPFG 846
+D P+F P P+ + + + F+T + S T + + P+ P SP
Sbjct: 266 ---PRDSPAF--PDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSP---SP-- 315
Query: 847 IKLRRTNYSLRFNCDQQAEQKKKKRHSSTGDSADAG-----------------PPAAGSA 889
++ YSL + + ++ T + A P GS
Sbjct: 316 -QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSE 374
Query: 890 RGE--KEMEGVALKHGPSLPQERKQAPSTRRDSAEPSSSRSVPVAHPGPPPASSQTPAPE 947
+ E +E E VA + P +++ P + + + P P PA+S P
Sbjct: 375 QKEPPEEAEPVAAAE--------PEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPS 426
Query: 948 HDKAANKMPLAQKPALAPKPTSQTPPASPLSKLSRPYLVELLSRRAGRPDPEPSEPSKED 1007
+ K A P + PP S K S V L D E P
Sbjct: 427 AGQQEAKTDQADGP--------REPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRS-- 476
Query: 1008 QESSDRRPPSPPGPEERKGQKRDEEEEATERK-----PASPPLPATQQEKPSQTP-EAGR 1061
+ PS P P + + +R P S P + TP
Sbjct: 477 ------KTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDP 530
Query: 1062 KEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQKGFREQQATREER-KQAREAKQAE 1120
K + + R L+ L K E Q + K++ E + REER ++ +A++
Sbjct: 531 KCSFVEKERQRLE--NLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERV 588
Query: 1121 KLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEK-RPETAVSRLE----RREQLKKANTL 1175
+ KE ++ + + K L EEK + + A ++E RR+Q ++A L
Sbjct: 589 EQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 648
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 85.9 bits (211), Expect = 2e-16
Identities = 78/269 (28%), Positives = 136/269 (50%), Gaps = 26/269 (9%)
Query: 218 EEERRRQEDYWRELEAK-CKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEG 276
E+ER+R E+ R+ EA+ +RQK E ++RRLEE +L+ E RL + + +E +E+ E
Sbjct: 532 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKR-EERLRKVLQARERVEQMKEE 590
Query: 277 QEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQA-------QA 329
++ +E + A +E+ + + + +++ +++E E RR+ + +A Q
Sbjct: 591 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 650
Query: 330 EERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEET 389
EE RR +E L++++ +E+E R A E KR E+ + E E++E E + +E
Sbjct: 651 EEERRHQE--LLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 708
Query: 390 GEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPG 449
E R E++ E+E QA E +ER E RL+ E + EE
Sbjct: 709 REQERQLAEQERRREQERLQAERE------------LQER-EKALRLQKEQLQRELEEKK 755
Query: 450 ICEEQNPEAER--RREQQGRSGDFQGADR 476
EEQ AER + EQ+ ++ + GA +
Sbjct: 756 KKEEQQRLAERQLQEEQEKKAKEAAGASK 784
Score = 81.6 bits (200), Expect = 4e-15
Identities = 79/261 (30%), Positives = 133/261 (50%), Gaps = 30/261 (11%)
Query: 151 RLDNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHEQGG-----LESRPCLDQNGHPGEDKP 205
RL+N K + A + ++Q+V + RR ++ + ++ L++R ++Q E+K
Sbjct: 537 RLENLRRKEE-AEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK---EEKK 592
Query: 206 TWHEEEPNPLDSEEERRRQEDYWRE-LEAKCKRQKAEAAEKRRLEEQRLQALE--RRLWE 262
E++ +D + E+ ++E E + K +K E E RR +E+ + L ++ E
Sbjct: 593 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 652
Query: 263 ENRRQELLEEEGEGQEPPL-EAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERR 321
E R QELL+++ E ++ L +A A R +QR E + ERRE+E RE+ E+ERR
Sbjct: 653 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER---REQERREQERREQERREQERR 709
Query: 322 RLQAQAQAEERRRLEEDARLEERRRQEEEEG---------RCAEELKRQEEE----EAEG 368
+ Q AE+ RR E++ ER QE E+ R EE K++EE+ E +
Sbjct: 710 EQERQL-AEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQL 768
Query: 369 WEELEQQEAEVQGPPEALEET 389
EE E++ E G +AL T
Sbjct: 769 QEEQEKKAKEAAGASKALNVT 789
Score = 77.8 bits (190), Expect = 6e-14
Identities = 71/277 (25%), Positives = 132/277 (47%), Gaps = 32/277 (11%)
Query: 236 KRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPR------- 288
KR + + E QRL+ L R+ E R++ +EE+ + ++ +R R
Sbjct: 521 KRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQA 580
Query: 289 --------EEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQ--AQAEERRRLEED 338
EE+++ +E + E+ E+ + ERL E+ +++ A+ + E RR+ EE+
Sbjct: 581 RERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE 640
Query: 339 ARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEE 398
AR +QEEEE R E L++++EEE +E ++ AE + E E+ E R
Sbjct: 641 ARRLRWLQQEEEERRHQELLQKKKEEE----QERLRKAAEAKRLAEQREQ--ERREQERR 694
Query: 399 EDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEA 458
E E+E + + QL+E +ER +QERL+ E + + E+ +++ +
Sbjct: 695 EQERREQERREQERREQERQLAE-----QERRREQERLQAERELQEREKALRLQKEQLQR 749
Query: 459 E----RRREQQGRSGDFQGADRPGPEEKREEGDTEPL 491
E +++E+Q R + Q + + K G ++ L
Sbjct: 750 ELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKAL 786
Score = 75.5 bits (184), Expect = 3e-13
Identities = 73/227 (32%), Positives = 115/227 (50%), Gaps = 33/227 (14%)
Query: 173 KHRRLAQDPQHEQGGLESRPCLDQNGHPGED--KPTWHEEEPNPLDSEEERRRQEDYWRE 230
K RLA++ ++ + ++ E+ + W ++E EEERR QE ++
Sbjct: 610 KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE------EEERRHQELLQKK 663
Query: 231 LEAKCKRQKAEAAEKRRLEEQRLQAL--ERRLWEENRRQELLEEEGEGQEPPLEAERAPR 288
E + +R + +AAE +RL EQR Q + R +E R QE E+E QE L AE+ R
Sbjct: 664 KEEEQERLR-KAAEAKRLAEQREQERREQERREQERREQERREQERREQERQL-AEQERR 721
Query: 289 EEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQE 348
EQ+R L+A + E +ERE+ RL+ E Q Q + EE+++ EE RL ER+ QE
Sbjct: 722 REQER-LQA----ERELQEREKALRLQKE------QLQRELEEKKKKEEQQRLAERQLQE 770
Query: 349 EEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPP-EALEETGEGRR 394
E+E ++ +EA G + +VQ P + + T +G R
Sbjct: 771 EQE---------KKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHR 808
Score = 72.8 bits (177), Expect = 2e-12
Identities = 101/420 (24%), Positives = 178/420 (42%), Gaps = 55/420 (13%)
Query: 149 IARLDNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQ---NGHPGEDKP 205
+ RL N K+ + K+ + A+ E G S P D N P KP
Sbjct: 359 LERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNP-KP 417
Query: 206 TWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKA------EAAEKRRLEEQRLQALERR 259
E +E + Q D RE +R+++ E E++ LE++ LQ +
Sbjct: 418 AASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK 477
Query: 260 LWEEN-------RRQELLEEEGEGQEPPLEAERAPREEQQRSLE--APGWEDAERREREE 310
R + + + APR + ++ P D + +ER+
Sbjct: 478 TPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQR 537
Query: 311 RERLEAEEERRRLQAQAQAEERRRLEEDARL--EERRRQEEEEGRCAEELKRQEEEEAE- 367
E L +EE +L+ Q E++RR E+ +L EER R+ + E++K +++++ E
Sbjct: 538 LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQ 597
Query: 368 ------------GWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLG----EEEEEGQAH 411
E L +++A+ + + +EE E RR EEE ++EEE + H
Sbjct: 598 KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV-EARRKQEEEARRLRWLQQEEEERRH 656
Query: 412 LEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDF 471
ELL +E E+QERL+ + + E EQ + RREQ+ R +
Sbjct: 657 --------QELLQKKKE--EEQERLRKAAEAKRLAEQ---REQERREQERREQERREQER 703
Query: 472 QGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDERQ 531
+ +R E++R+ + E +QE ++A + ER++A L++ + EL ++ E Q
Sbjct: 704 REQER--REQERQLAEQERRREQE-RLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 760
Score = 48.1 bits (113), Expect = 5e-05
Identities = 112/547 (20%), Positives = 196/547 (35%), Gaps = 71/547 (12%)
Query: 642 PGDARAGSGKAKPRQESPSSASALAEWASIRSRILKNAESDPRSSERDQLRPGDESTPRG 701
P +R S + +PSS S A S + K R+S R + +E G
Sbjct: 293 PTGSRTDSQSVRHSPIAPSSPSPQV-LAQKYSLVAKQESVVRRASRRLAKKTAEEPAASG 351
Query: 702 R--CDSR-------------GNQRKTPPVNAKFSIMPAWQKFSDGGTETSKQSTEAESIR 746
R C S G+++K PP A+ + A + + S + E
Sbjct: 352 RIICHSYLERLLNVEVPQKVGSEQKEPPEEAE-PVAAAEPEVPENNGNNSWPHNDTEIAN 410
Query: 747 KRPMLGPSEETAPQPPPAGVRELGKGPEKSEMHREPADTTEGCKFAKDLPSFL------- 799
P P+ ++P+ P AG +E ++++ REP + + K S L
Sbjct: 411 STPNPKPAA-SSPETPSAGQQEAKT--DQADGPREPPQSARRKRSYKQAVSELDEEQHLE 467
Query: 800 ----------VPSLPYPPQKVVAHTE---FTTSSDSETANGIAKPDPVMPGGEEKASPFG 846
PS P P KVV T + + P VM ++ +P
Sbjct: 468 DEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLR 527
Query: 847 IKLRRTNYSLRFNCDQQAEQKKKKRHSSTGDSADAGPPAAGSARGEKEMEGVALKHGPSL 906
+ + N ++ E ++ +R D + +E V LK
Sbjct: 528 MDPKEKERQRLENLRRKEEAEQLRRQKVEEDK-------------RRRLEEVKLKR---- 570
Query: 907 PQERKQAPSTRRDSAEPSSSRSVPVAHPGPPPASSQTPAPEHDKAANKMPLAQKPALAPK 966
+ER + R+ E +T + ++ A + A+K A A K
Sbjct: 571 -EERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEK--AKKKAAAKK 627
Query: 967 PTSQTPPASPLSKLSRPYLVELLSRRAGRPDPEPSEPSKEDQESSDRRPPSPPG-PEERK 1025
+ R L L R E + KE+++ R+ E+R+
Sbjct: 628 MEEVEARRKQEEEARR--LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE 685
Query: 1026 GQKRDEEEEATERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETA 1085
++R++E ER+ ++++ + R+E+ LQ+ L + EK
Sbjct: 686 QERREQERREQERREQERREQERREQERQLAEQERRREQERLQAEREL---QEREKALRL 742
Query: 1086 QPLWITLALQKQKGFREQQATRE---ERKQAREAKQAEKLSKE-NVSVSVQ-PGSSSVSR 1140
Q + L+++K EQQ E + +Q ++AK+A SK NV+V VQ P +S
Sbjct: 743 QKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQM 802
Query: 1141 AGSLHKS 1147
H++
Sbjct: 803 TPQGHRA 809
Score = 43.5 bits (101), Expect = 0.001
Identities = 104/521 (19%), Positives = 185/521 (35%), Gaps = 102/521 (19%)
Query: 729 SDGGTETSKQSTEAESIRKRPMLGPSEETAPQPPPAGVRELGKGPEKSEMHREPADTTEG 788
S G + ++ST +S K +L ++ P + G G +S A + G
Sbjct: 208 SQGIPTSDEESTPKKS--KARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPG 265
Query: 789 CKFAKDLPSFLVPSLPYPPQKV--VAHTEFTTSSDSETANGIAKPDPVMPGGEEKASPFG 846
+D P+F P P+ + + + F+T + S T + + P+ P SP
Sbjct: 266 ---PRDSPAF--PDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSP---SP-- 315
Query: 847 IKLRRTNYSLRFNCDQQAEQKKKKRHSSTGDSADAG-----------------PPAAGSA 889
++ YSL + + ++ T + A P GS
Sbjct: 316 -QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSE 374
Query: 890 RGE--KEMEGVALKHGPSLPQERKQAPSTRRDSAEPSSSRSVPVAHPGPPPASSQTPAPE 947
+ E +E E VA + P +++ P + + + P P PA+S P
Sbjct: 375 QKEPPEEAEPVAAAE--------PEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPS 426
Query: 948 HDKAANKMPLAQKPALAPK----------------------------PTSQTPPA-SPLS 978
+ K A P P+ P S+TP + P S
Sbjct: 427 AGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPAS 486
Query: 979 KLSRPYLVELLSRRAGRPDPEP-SEPSKEDQESSDRRPPSPPGPEERKGQ-----KRDEE 1032
K+ RP L + + + P S P + R P P+E++ Q +R EE
Sbjct: 487 KVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEE 546
Query: 1033 EEATERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSK-------------LT 1079
E R+ +E + E RK +LQ+R ++ K +
Sbjct: 547 AEQLRRQKVEEDKRRRLEEVKLKREERLRK---VLQARERVEQMKEEKKKQIEQKFAQID 603
Query: 1080 EKVETAQPLWITLALQKQKG----FREQQATREERKQAR-----EAKQAEKLSKENVSVS 1130
EK E A+ + K+K E +A R++ ++AR + ++ E+ +E +
Sbjct: 604 EKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKK 663
Query: 1131 VQPGSSSVSRAGSLHKSTALPEEKRPETAVSRLERREQLKK 1171
+ + +A + E++R E ERREQ ++
Sbjct: 664 KEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR 704
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 85.5 bits (210), Expect = 3e-16
Identities = 112/390 (28%), Positives = 171/390 (43%), Gaps = 56/390 (14%)
Query: 132 SSAGTIESVNLDAIPLAIARLDNSAAKHKLAVKPKKQRVSKKHRRLAQDPQHE-----QG 186
+S+ T+E + LA+A LD+S+A + + ++ R ++ +HE +
Sbjct: 79 ASSTTLEDLESQYQELAVA-LDSSSA----IISQLTENINSLVRTSKEEKKHEIHLVQKL 133
Query: 187 GLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEE--RRRQEDYWRELEAKCKRQKA---- 240
G +Q P +P + L E R+ E R+L+A+ + +
Sbjct: 134 GRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLL 193
Query: 241 ---------EAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPL-EAERAPREE 290
E E+ R +E+RL+ E RL E+ R EE QE L E E RE
Sbjct: 194 NRRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLREH 253
Query: 291 QQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRL-EEDARL--EERRRQ 347
++R E E R E+ ERL +EER Q + E+ RL E++ RL +E R +
Sbjct: 254 EERLCE------QEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLR 307
Query: 348 EEEEGRC-AEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEE 406
E+EE C EE R++EE E+L QE ++ + LE+ RR E+E L E E
Sbjct: 308 EQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQE---RRQEEQERLLERE- 363
Query: 407 EGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQG 466
LL + EE LE QERL+ + +R +E E+ E ER E
Sbjct: 364 --------------RLLEEVEELLE-QERLRQQDERLWQQETLQELERLRELERMLELGW 408
Query: 467 RSGDFQGAD-RPGPEEKREEGDTEPLLKQE 495
+ Q A+ R G EE E + L+Q+
Sbjct: 409 EALYEQRAEPRSGFEELNNENKSTLQLEQQ 438
Score = 79.3 bits (194), Expect = 2e-14
Identities = 90/290 (31%), Positives = 136/290 (46%), Gaps = 29/290 (10%)
Query: 244 EKRRLEEQRLQALERRLWE-ENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWED 302
E+++ E +Q L R L++ +N+ E L E +E + ++ LE+ G
Sbjct: 121 EEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVG--- 177
Query: 303 AERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEE-LKRQ 361
+L+AE E ++ + + RL E EER R++EE R EE L Q
Sbjct: 178 ---------RQLQAEVENNQMLSLLNRRQEERLREQ---EERLREQEERLREQEERLCEQ 225
Query: 362 EEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSE 421
EE E E L +QE + E L E E R E+E+ E+EE E+ + E
Sbjct: 226 EERLREQEERLREQEERLCEQEERLREHEE--RLCEQEERLCEQEERLREQEERLHEQEE 283
Query: 422 LLNDFEERL-EDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPE 480
L + EERL E +ERL + +R +E +CE++ ER REQ+ R + + PG E
Sbjct: 284 RLCEQEERLREQEERLCEQEERLREQEERLCEQE----ERLREQEERLCEQE--KLPGQE 337
Query: 481 EKREEGDTEPLLKQEGPVEAAQPPVERKEAAALEQGRKVEELRWQEVDER 530
EE E LL+QE E + +ER E E +E+ R ++ DER
Sbjct: 338 RLLEE--VEKLLEQERRQEEQERLLER-ERLLEEVEELLEQERLRQQDER 384
Score = 73.9 bits (180), Expect = 9e-13
Identities = 82/288 (28%), Positives = 128/288 (44%), Gaps = 38/288 (13%)
Query: 166 KKQRVSKKHRRLAQDPQH--EQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRR 223
+++R+ ++ RL + + EQ E R C E + E+E + EE
Sbjct: 197 QEERLREQEERLREQEERLREQ---EERLC--------EQEERLREQEERLREQEERLCE 245
Query: 224 QEDYWRELEAK-CKRQK--AEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPP 280
QE+ RE E + C++++ E E+ R +E+RL E RL E+ R E +E
Sbjct: 246 QEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLR------EQEERL 299
Query: 281 LEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDAR 340
E E RE+++R E+ ERL +EER Q + +ER E +
Sbjct: 300 CEQEERLREQEERLC-------------EQEERLREQEERLCEQEKLPGQERLLEEVEKL 346
Query: 341 LEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEED 400
LE+ RRQEE+E E +E EE E L QQ+ E E L+E R +
Sbjct: 347 LEQERRQEEQERLLERERLLEEVEELLEQERLRQQD-ERLWQQETLQELERLRELERMLE 405
Query: 401 LGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEP 448
LG E Q + R EL N+ + L+ ++++K + +EEP
Sbjct: 406 LGWEALYEQR--AEPRSGFEELNNENKSTLQLEQQVKELKKSGGAEEP 451
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 85.1 bits (209), Expect = 4e-16
Identities = 70/309 (22%), Positives = 129/309 (41%), Gaps = 39/309 (12%)
Query: 201 GEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRL 260
GE+ + + P + +E+ ++D R+ + + AE + R++E+
Sbjct: 77 GEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHARVKER--------- 127
Query: 261 WEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEER 320
E RR+ EE+ + + E ER R E R + RRER+ E+LE + ER
Sbjct: 128 -EHERRKRHREEQDKARR---EWERQKRREMAR--------EHSRRERDRLEQLERKRER 175
Query: 321 RRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQ 380
R + Q E+R + E + R EERR++ E + + E+ ++ + + +
Sbjct: 176 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 235
Query: 381 GPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEG 440
PP E G+GR+ +EE + E +LL+D ++ + D ER
Sbjct: 236 -PPRERFELGDGRKPVKEEKMEER----------------DLLSDLQD-ISDSERKTSSA 277
Query: 441 QREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEA 500
+ +E EE+ E E E+ S + + + EE+ E G ++ E
Sbjct: 278 ESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV 337
Query: 501 AQPPVERKE 509
++ + E
Sbjct: 338 SEEEMSEDE 346
Score = 74.7 bits (182), Expect = 5e-13
Identities = 77/291 (26%), Positives = 124/291 (42%), Gaps = 42/291 (14%)
Query: 153 DNSAAKHKLAVKPKKQ--RVSKKHRRLAQDPQHE--------QGGLESRPCLDQNGHPGE 202
D LA+KP +Q R K H R + + + +GG +R + + H
Sbjct: 75 DRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHAR--VKEREHERR 132
Query: 203 DKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWE 262
+ H EE + E ER+++ + RE ++ +R + E E++R E++++ ++ E
Sbjct: 133 KR---HREEQDKARREWERQKRREMARE-HSRRERDRLEQLERKRERERKMREQQKEQRE 188
Query: 263 ENRRQELLEEEGEGQEPPLEAE---RAPREEQQRSLEAPGWEDAERREREERERL----- 314
+ R+ EE + +E E R RE+ ++A W + R ER L
Sbjct: 189 QKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRK 248
Query: 315 ----EAEEERRRL---------QAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQ 361
E EER L + + + E E + EE +EEEE EE
Sbjct: 249 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE---EEEGSTS 305
Query: 362 EEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHL 412
EE E E EE E++E EA E++ E +EEE +EE E + HL
Sbjct: 306 EESEEEEEEEEEEEEETGSNSEEASEQSAE--EVSEEEMSEDEERENENHL 354
Score = 63.9 bits (154), Expect = 9e-10
Identities = 61/256 (23%), Positives = 102/256 (39%), Gaps = 28/256 (10%)
Query: 164 KPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRR 223
K +++ +K R +A++ + R L+Q E + E++ + +E RR
Sbjct: 141 KARREWERQKRREMAREHSRRE-----RDRLEQLERKRERERKMREQQKEQREQKERERR 195
Query: 224 QEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLE--EEGEGQEPPL 281
E+ +E EA+ + +A R + E ++ W + + E E G+G++P
Sbjct: 196 AEERRKEREAR----REVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVK 251
Query: 282 EAERAPRE---------EQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEER 332
E + R+ + +R + AE E E E EEE ++EE
Sbjct: 252 EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE 311
Query: 333 RRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEG 392
EE +EEE G +EE Q EE E E +E E + + E+
Sbjct: 312 E--------EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFD 363
Query: 393 RRGAEEEDLGEEEEEG 408
R E E+ EE EG
Sbjct: 364 RDSGESEEAEEEVGEG 379
Score = 39.7 bits (91), Expect = 0.018
Identities = 48/222 (21%), Positives = 93/222 (41%), Gaps = 34/222 (15%)
Query: 342 EERRRQEEEEGRCAEELKRQEEEEAEGWEELEQ-------QEAEVQGPPEALEETGEGRR 394
E++RR+E+EE + LK ++ +++ + LE+ E ++ P E++ E R
Sbjct: 19 EKKRRKEQEEKAEIKRLKNSDDRDSKR-DSLEEGELRDHCMEITIRNSPYRREDSMED-R 76
Query: 395 GAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPG----I 450
G E++ L + + + E +D++R + HS E G +
Sbjct: 77 GEEDDSLAIKPPQQMSRKEK------------VHHRKDEKRKEKCRHHSHSAEGGKHARV 124
Query: 451 CEEQNPEAERRREQQG---RSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVER 507
E ++ +R RE+Q R + Q E R E D L+++ E ++
Sbjct: 125 KEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQK 184
Query: 508 KEAAALEQGRKVEELRWQEVDERQ------TMPRPYTFQVSS 543
++ E+ R+ EE R + R+ TM Y+ +V +
Sbjct: 185 EQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKA 226
Score = 31.6 bits (70), Expect = 4.9
Identities = 45/226 (19%), Positives = 93/226 (41%), Gaps = 30/226 (13%)
Query: 982 RPYLVELLSRRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEE----RKGQKRDEE----- 1032
R + +E+ R + + E E+ +S +PP +E RK +KR E+
Sbjct: 54 RDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHS 113
Query: 1033 ------EEATERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQ 1086
+ A ++ ++E+ E R+++ + HS E++E +
Sbjct: 114 HSAEGGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKR 173
Query: 1087 PLWITLALQKQKGFREQQATREERKQAR---EAKQAEKLSKENVSV---SVQPGSSSVSR 1140
++++ REQQ + E+K+ E ++ E+ ++ VS +++ S +
Sbjct: 174 --------ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVK 225
Query: 1141 AGSLHKSTALPEEKRPETAVSRLERREQLKKANTLPTSVTVEISDS 1186
A +S P +R E R +E+ + L + + +ISDS
Sbjct: 226 ASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQ-DISDS 270
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 85.1 bits (209), Expect = 4e-16
Identities = 91/369 (24%), Positives = 153/369 (41%), Gaps = 48/369 (13%)
Query: 216 DSEEERRRQEDYWRELEAKCKRQKAEAAE-KRRLEEQRLQALERRLWEENRRQELLEEEG 274
DS E+R ++D L K +Q + + R +E+R + R+ E+ R E +
Sbjct: 71 DSMEDRGEEDD---SLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR 127
Query: 275 EGQEPPL-EAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERR 333
E Q+ E ER R E R + RRER+ E+LE + ER R + Q E+R
Sbjct: 128 EEQDKARREWERQKRREMAR--------EHSRRERDRLEQLERKRERERKMREQQKEQRE 179
Query: 334 RLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGR 393
+ E + R EERR++ E + + E+ ++ + + + PP E G+GR
Sbjct: 180 QKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR-PPRERFELGDGR 238
Query: 394 RGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEE 453
+ +EE + E +LL+D ++ + D ER K S E G E
Sbjct: 239 KPVKEEKMEER----------------DLLSDLQD-ISDSER-KTSSAESSSAESGSGSE 280
Query: 454 QNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAAAL 513
+ E E E++G + + + EE+ EE + E E E + V +E +
Sbjct: 281 EEEEEEEEEEEEGSTSE----ESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED 336
Query: 514 EQGRKVEELRWQEVDERQTMPRPYTFQVSSGGKQILFPKVNLSPVTPAKDTGLTAAPQEP 573
E+ +E + + F SG + +V TP + + LT P
Sbjct: 337 EE---------RENENHLLVVPESRFDRDSGESEEAEEEVGEG--TP-QSSALTEGDYVP 384
Query: 574 KAPKASPVQ 582
+P SP++
Sbjct: 385 DSPALSPIE 393
Score = 79.3 bits (194), Expect = 2e-14
Identities = 85/357 (23%), Positives = 149/357 (41%), Gaps = 52/357 (14%)
Query: 201 GEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRL 260
GE+ + + P + +E+ ++D R+ + + ++ E +RR + Q RR
Sbjct: 77 GEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARRE 136
Query: 261 WEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEER 320
WE +R+E+ E + LE RE +++ E + E+RE++ERER AEE R
Sbjct: 137 WERQKRREMAREHSRRERDRLEQLERKRERERKMRE----QQKEQREQKERER-RAEERR 191
Query: 321 RRLQAQAQAEERRRLEEDARLEE--------------RRRQEEEEGRC-AEELKRQEEEE 365
+ +A+ + R + ++ R R E +GR +E K +E +
Sbjct: 192 KEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDL 251
Query: 366 AEGWEELEQQEAEVQGPPEALEETGEGRRGAEEEDL-----------GEEEEEGQAHLED 414
+++ E + + E+G G EEE+ EEEEE + E+
Sbjct: 252 LSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEE 311
Query: 415 WRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGA 474
G SE ++ +E + + +RE+ + PE+ R+ SG+ + A
Sbjct: 312 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVV----PESRFDRD----SGESEEA 363
Query: 475 DRPGPEEKREEGDTEPLLKQEG---PVEAAQPPVERKE-----AAALEQGRKVEELR 523
EE+ EG + EG P A P+E K+ AL+ R VEE +
Sbjct: 364 -----EEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQ 415
Score = 63.9 bits (154), Expect = 9e-10
Identities = 61/256 (23%), Positives = 102/256 (39%), Gaps = 28/256 (10%)
Query: 164 KPKKQRVSKKHRRLAQDPQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRR 223
K +++ +K R +A++ + R L+Q E + E++ + +E RR
Sbjct: 132 KARREWERQKRREMAREHSRRE-----RDRLEQLERKRERERKMREQQKEQREQKERERR 186
Query: 224 QEDYWRELEAKCKRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLE--EEGEGQEPPL 281
E+ +E EA+ + +A R + E ++ W + + E E G+G++P
Sbjct: 187 AEERRKEREAR----REVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVK 242
Query: 282 EAERAPRE---------EQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEER 332
E + R+ + +R + AE E E E EEE ++EE
Sbjct: 243 EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE 302
Query: 333 RRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEG 392
EE +EEE G +EE Q EE E E +E E + + E+
Sbjct: 303 E--------EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFD 354
Query: 393 RRGAEEEDLGEEEEEG 408
R E E+ EE EG
Sbjct: 355 RDSGESEEAEEEVGEG 370
Score = 43.5 bits (101), Expect = 0.001
Identities = 49/212 (23%), Positives = 95/212 (44%), Gaps = 23/212 (10%)
Query: 342 EERRRQEEEEGRCAEELKRQEEEEAEGWEELEQ-------QEAEVQGPPEALEETGEGRR 394
E++RR+E+EE + LK ++ +++ + LE+ E ++ P E++ E R
Sbjct: 19 EKKRRKEQEEKAEIKRLKNSDDRDSKR-DSLEEGELRDHCMEITIRNSPYRREDSMED-R 76
Query: 395 GAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPGICEEQ 454
G E++ L + + + E + E+R E + E +REH EEQ
Sbjct: 77 GEEDDSLAIKPPQQMSRKEKVHHRKD------EKRKEKKHARVKEKEREHERRKRHREEQ 130
Query: 455 NPEAERRREQQGR---SGDFQGADRPGPEEKREEGDTEPLLKQEGPVEAAQPPVERKEAA 511
+ +A R E+Q R + + +R E+ + + E ++++ + Q ER+
Sbjct: 131 D-KARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERR--- 186
Query: 512 ALEQGRKVEELRWQEVDERQTMPRPYTFQVSS 543
E+ RK E R + +TM Y+ +V +
Sbjct: 187 -AEERRKEREARREVSAHHRTMREDYSDKVKA 217
Score = 37.7 bits (86), Expect = 0.068
Identities = 46/217 (21%), Positives = 94/217 (43%), Gaps = 21/217 (9%)
Query: 982 RPYLVELLSRRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEE----RKGQKRDEEEEA-- 1035
R + +E+ R + + E E+ +S +PP +E RK +KR E++ A
Sbjct: 54 RDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARV 113
Query: 1036 TERKPASPPLPATQQEKPSQTPEAGRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQ 1095
E++ ++E+ E R+++ + HS E++E + +
Sbjct: 114 KEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKR--------E 165
Query: 1096 KQKGFREQQATREERKQAR---EAKQAEKLSKENVSV---SVQPGSSSVSRAGSLHKSTA 1149
+++ REQQ + E+K+ E ++ E+ ++ VS +++ S +A +S
Sbjct: 166 RERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPP 225
Query: 1150 LPEEKRPETAVSRLERREQLKKANTLPTSVTVEISDS 1186
P +R E R +E+ + L + + +ISDS
Sbjct: 226 RPPRERFELGDGRKPVKEEKMEERDLLSDLQ-DISDS 261
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.125 0.351
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,950,455
Number of Sequences: 37866
Number of extensions: 3820947
Number of successful extensions: 67502
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 844
Number of HSP's successfully gapped in prelim test: 2619
Number of HSP's that attempted gapping in prelim test: 19119
Number of HSP's gapped (non-prelim): 21264
length of query: 1233
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1119
effective length of database: 13,930,794
effective search space: 15588558486
effective search space used: 15588558486
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.