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Search of human proteins with 148596949
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
(699 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 1341 0.0
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 149 1e-35
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 149 1e-35
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 149 1e-35
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 149 1e-35
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 144 3e-34
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 141 2e-33
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 141 2e-33
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 112 1e-24
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 105 1e-22
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 105 1e-22
gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 105 1e-22
gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 105 1e-22
gi|55741677 SET domain containing 1A [Homo sapiens] 105 1e-22
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ... 100 4e-21
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 98 3e-20
gi|104526627 triadin [Homo sapiens] 96 1e-19
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 95 3e-19
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 95 3e-19
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens] 94 4e-19
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 94 6e-19
gi|163965366 nascent polypeptide-associated complex alpha subuni... 89 1e-17
gi|125656165 THO complex 2 [Homo sapiens] 89 2e-17
gi|150170670 piccolo isoform 2 [Homo sapiens] 87 7e-17
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 87 7e-17
gi|150378539 piccolo isoform 1 [Homo sapiens] 87 7e-17
gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens] 86 9e-17
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 86 2e-16
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 86 2e-16
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 85 2e-16
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 1341 bits (3470), Expect = 0.0
Identities = 699/699 (100%), Positives = 699/699 (100%)
Query: 1 MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKS 60
MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKS
Sbjct: 1 MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKS 60
Query: 61 AKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAA 120
AKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAA
Sbjct: 61 AKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAA 120
Query: 121 AKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPP 180
AKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPP
Sbjct: 121 AKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPP 180
Query: 181 KNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK 240
KNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK
Sbjct: 181 KNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK 240
Query: 241 KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPP 300
KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPP
Sbjct: 241 KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPP 300
Query: 301 KKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAE 360
KKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAE
Sbjct: 301 KKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAE 360
Query: 361 SSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRK 420
SSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRK
Sbjct: 361 SSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRK 420
Query: 421 ADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEE 480
ADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEE
Sbjct: 421 ADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEE 480
Query: 481 EEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPR 540
EEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPR
Sbjct: 481 EEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPR 540
Query: 541 PQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQA 600
PQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQA
Sbjct: 541 PQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQA 600
Query: 601 KKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQ 660
KKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQ
Sbjct: 601 KKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQ 660
Query: 661 VLKFTKGKSFRHEKTKKKRGSYRGGSISVQVNSIKFDSE 699
VLKFTKGKSFRHEKTKKKRGSYRGGSISVQVNSIKFDSE
Sbjct: 661 VLKFTKGKSFRHEKTKKKRGSYRGGSISVQVNSIKFDSE 699
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 149 bits (375), Expect = 1e-35
Identities = 209/798 (26%), Positives = 297/798 (37%), Gaps = 169/798 (21%)
Query: 1 MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKS 60
MA+A RR +L PL+ L A + + +G A +LLDIY+ W ++
Sbjct: 1 MAEARKRR----ELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQT 56
Query: 61 AKVPERKLQANGPVAKKAKKKASSS--DSEDSSEEEEEVQGPPAK--------------- 103
+++ RK +A A +AKK S + +SSEEEEE + AK
Sbjct: 57 SEL-GRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGA 115
Query: 104 --------KAAVPAKRVG-----LP---PGKAAAKASESSSSEESSDDDDEEDQKKQPVQ 147
KA ++ G +P GK A S +S++ + +
Sbjct: 116 DLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175
Query: 148 KGVKPQAKAAKAPPK-KAKSSDSDSD--SSSEDEPPKNQKPKITPVTVKAQT-------- 196
+G P AA P A +DS S+ SSS DE KP + P VKA +
Sbjct: 176 EGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPA 235
Query: 197 -KAPPKPAR---AAPKIANG------KAASSSSSSSSSSSSDDSEEE------------- 233
KA P P + P++ G +A S SS +SEEE
Sbjct: 236 RKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASE 295
Query: 234 -----KAAATPKKTVPKKQVVAKAPVKA--------ATTPTRKSSSSEDSSSDEEEE--- 277
+AA+ P K P K P KA A P S SS + SSD EEE
Sbjct: 296 KILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355
Query: 278 QKKPMKNK-PGPYSSVPPPSAP---PPKKSLGTQPPKK---AVEKQQPVESSEDSSDESD 330
K ++ K G S V SAP P+K PP K AV K Q + EDS S+
Sbjct: 356 AKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSE 415
Query: 331 SSSEEEKKP-----------------PTKAVVSKATTKPPP------------AKKAAES 361
S EE+ P P K K PP K+ +S
Sbjct: 416 ESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDS 475
Query: 362 SSDSSDSDSSED-----DEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKL 416
S S +SDS + + A KP G K+ KPA T + A P P G
Sbjct: 476 RSSSEESDSDREALAAMNAAQVKPLG--KSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT 533
Query: 417 LTRKA-----DSSSSEEESSSSEEEKTKKMVATTKPKATAK----AALSLPAKQAPQGS- 466
+ + DS SS EESS S + + VA + K+ S PAK PQ +
Sbjct: 534 PSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
Query: 467 -------------RDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGK 513
SS+ S S++ EE + +A + KP P A KK
Sbjct: 594 PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL----KIPQTKACPKKTN 649
Query: 514 AESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKA 573
+S + + K SP +P G + A++ +++ S + EEEK
Sbjct: 650 TTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES-DSEEEKTGL 708
Query: 574 AVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEI 633
AV V ++ S+ K Q K A P + T P + + P + E
Sbjct: 709 AVTVGQAKSVGKGLQ---VKAASVPVKGSLGQGTAPVLPGK-------TGPTVTQVKAEK 758
Query: 634 EVDSRVADNSFDAKRGAA 651
+ DS ++ D++ AA
Sbjct: 759 QEDSESSEEESDSEEAAA 776
Score = 138 bits (348), Expect = 2e-32
Identities = 176/677 (25%), Positives = 244/677 (36%), Gaps = 161/677 (23%)
Query: 67 KLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASES 126
K AN K +K A S + E EE + +VPA PG +A ++S
Sbjct: 146 KTVANLLSGKSPRKSAEPSANTTLVSETEE-------EGSVPAFGAAAKPGMVSAGQADS 198
Query: 127 SSSEESSDDDDEEDQ-----------------KKQPVQKG---------VKPQAKAAKAP 160
SS + SS D+ + + K+ P +K V PQ K P
Sbjct: 199 SSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALP 258
Query: 161 P-KKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTK--------APPK--PARAAPKI 209
P K+AK + +S+SS E + + P T VKA K AP K P + A
Sbjct: 259 PAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPA 318
Query: 210 ANGKAASSSS----------SSSSSSSSDDSEEEK-------------------AAATPK 240
GKA + +S S SSS S DSEEE AA+ P
Sbjct: 319 PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA 378
Query: 241 KTVPKKQVVAKAPVKAATTPTR---------KSSSSEDSSSDEEEEQKKPMKNKPGPYSS 291
K P+K P K + SSSE+S S+EE + K +
Sbjct: 379 KESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438
Query: 292 VPPPSAPPPKKSLGTQPPKKA------VEKQQPVESSEDSSDESDSSSEE---------- 335
P+ P+K PP+K V+ + E S SS+ESDS E
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
Query: 336 --EKKPPTKAV-------------------VSKATTKPPPAKKAAESSSDSSDSDSSEDD 374
K P K V AT K +S S S +S S D
Sbjct: 499 PLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG 558
Query: 375 EAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVG--GGQKLLTRKADSSSSEEESSS 432
E P+ A + S + P PA P Q G Q + D+S S EESS
Sbjct: 559 EVPTAVAPAQEKSLGN--ILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 433 SEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKK 492
S + + + A AA + PA + PQ + ++S++ + A +K
Sbjct: 617 SADSE--------EAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK 668
Query: 493 KPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEE----------KLKGKGSP--- 539
A A S PA A + + +SSSS++S EEE+ K GKG
Sbjct: 669 --AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKA 726
Query: 540 ----------RPQAPKANGTSALTAQNGKAAK-----NSEEEEEEKKKAAVVVSKSGSLK 584
+ AP G + T KA K +SEEE + ++ AA S+K
Sbjct: 727 ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVK 786
Query: 585 KRKQNEAAKEAETPQAK 601
K + A P AK
Sbjct: 787 KTQAKANPAAARAPSAK 803
Score = 138 bits (348), Expect = 2e-32
Identities = 184/662 (27%), Positives = 254/662 (38%), Gaps = 173/662 (26%)
Query: 73 PVAKKAKKKASSSDS-EDSSEEEEEVQGPP------------AKKAAVPAK------RVG 113
P AK+AKK S+S E+ SE EEE + A+ PAK
Sbjct: 258 PPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATP 317
Query: 114 LPPGKAAAKASES----------SSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKK 163
PPGKA A AS++ SSSEESSD ++E P AKA
Sbjct: 318 APPGKAGAVASQTKAGKPEEDSESSSEESSDSEEET------------PAAKALLQAKAS 365
Query: 164 AKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSS 223
K+S + S+ E P+ + AP P + P +A +A S S
Sbjct: 366 GKTSQVGAASAPAKESPR-------------KGAAPAPPGKTGPAVAKAQAGKREEDSQS 412
Query: 224 SSSSDDSEEEKAA-ATPKKTVPKKQVVAKAPVK------AATTPTRKS------------ 264
SS DSEEE A A P P+ + A AP K AA P RK+
Sbjct: 413 SSEESDSEEEAPAQAKPSGKAPQVRA-ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQ 471
Query: 265 -----SSSEDSSSDEEE------EQKKPMKN----KPGPYSSVPP---PSAPPPKKSLGT 306
SSSE+S SD E Q KP+ KP + P + P P +G
Sbjct: 472 EEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGP 531
Query: 307 QPPKKAVEKQQPVESSEDSSDESDSSSEEE--------------------------KKPP 340
P V K + E SE SS+ES SS+ E K PP
Sbjct: 532 ATPSAQVGKWE--EDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPP 589
Query: 341 TKA---VVSKATTKPPPAKKAAESSSDSSDSDSSED--DEAPSKPA-------------G 382
KA V KP +++E SSDS+DS+ + A +KPA
Sbjct: 590 QKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTN 649
Query: 383 TTKNSSNKPA-VTTKSP-----AVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEE 436
TT ++ P V T++P A PA + GG Q R A+ SSS EES S EEE
Sbjct: 650 TTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ----RPAEDSSSSEESDS-EEE 704
Query: 437 KTKKMVATTKPKATAKA------------------ALSLPAKQAP---QGSRDSSSDSDS 475
KT V + K+ K A LP K P Q + DS+S
Sbjct: 705 KTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSES 764
Query: 476 SSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKG 535
S E + E+ + S + K V A + PA+A+ A+ + S+ + + K +
Sbjct: 765 SEEESDSEEAAASPAQVKTS-VKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRS 823
Query: 536 KGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEA 595
+P P N ++ G A+ S + A + S +++++ +EA
Sbjct: 824 PSKVKP--PVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881
Query: 596 ET 597
ET
Sbjct: 882 ET 883
Score = 128 bits (322), Expect = 2e-29
Identities = 193/776 (24%), Positives = 271/776 (34%), Gaps = 167/776 (21%)
Query: 61 AKVPERKLQANGPVA---KKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPG 117
AK P +K GPVA K K +S SE+SS+ + + P A AA + +P
Sbjct: 585 AKGPPQKA---GPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT 641
Query: 118 KAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPP-------------KKA 164
KA K + +++S K PV+ G + KA A + A
Sbjct: 642 KACPKKTNTTASA-----------KVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA 690
Query: 165 KSSDSDSDSSSEDEPP-------------KNQKPKITPVTVKA---QTKAPPKPARAAPK 208
+ S S +S SE+E K + K V VK Q AP P + P
Sbjct: 691 EDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPT 750
Query: 209 IANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSE 268
+ KA S SS SD E + A K +V K Q AKA AA P+ K + S
Sbjct: 751 VTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQ--AKANPAAARAPSAKGTISA 808
Query: 269 DS---SSDEEEEQKKPMKNKP---GPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESS 322
++ + +Q+ P K KP P +S P S+G A + P E S
Sbjct: 809 PGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDS 868
Query: 323 EDSSDESDSSSEEEK----KP------------PTKAVVSKATTKPPPAKK----AAESS 362
S +ESDS E E KP P K K PP K A
Sbjct: 869 GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK 928
Query: 363 SDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKAD 422
D S S S E D PA T KP + P PA P RKA
Sbjct: 929 QDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKAR 988
Query: 423 SSSSEEESSSSEEEKTKKMVAT------------TKPKATAKAALSLPAKQAPQGSRDSS 470
+S S SSSSE E + AT T P A + A A S++SS
Sbjct: 989 ASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGA-SSSKESS 1047
Query: 471 SDSDSSSSEEEEEKT-------------SKSAVKKKPQKVAGGAAPSKPASAKKGKAESS 517
SD E + S S K K+ P + K ++
Sbjct: 1048 RISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDD 1107
Query: 518 NSSSSDDSSEEEEEKLKGKGS--------PRPQ-------------------APKAN--- 547
+ SSD SS EE+ +G+ P P AP +
Sbjct: 1108 SEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLS 1167
Query: 548 --GTSALTAQNGKAAK---------------------NSEEEEEEKKKAAVVVSKSGSLK 584
T LT N +A+K + ++E + ++ A ++ K+G +
Sbjct: 1168 GYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKE 1227
Query: 585 ------KRKQNEAAKEAETPQAKKIKLQTPNT----FPKRKKGEKRASSPFRRVREEEIE 634
+K + K A PQA + LQ+ T E + + +V E +E
Sbjct: 1228 AASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLE 1287
Query: 635 VD-SRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGSISV 689
+ +V D + ++ R W R ++ K KKK G+ GG SV
Sbjct: 1288 QERKKVVDTTKESSRKG---WESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASV 1340
Score = 113 bits (282), Expect = 7e-25
Identities = 164/657 (24%), Positives = 262/657 (39%), Gaps = 105/657 (15%)
Query: 60 SAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPP--G 117
+A+ P K + P K A+ + S+ + V+ P + + V A+ P G
Sbjct: 796 AARAPSAKGTISAP--GKVVTAAAQAKQRSPSKVKPPVRNP--QNSTVLARGPASVPSVG 851
Query: 118 KAAAKASE--------SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAK---- 165
KA A A++ S SSEE SD ++E + Q G Q +AA AP K++
Sbjct: 852 KAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGA 911
Query: 166 ---------------SSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPP--------KP 202
DS SSSE+ + P AQ PP P
Sbjct: 912 APTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPA---AVTSAQVIKPPLIFVDPNRSP 968
Query: 203 ARAAPKIANGKAASS------SSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAP--- 253
A A A +AAS+ S S++ SSSS+ +E+ AT T + V P
Sbjct: 969 AGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAH 1028
Query: 254 --VKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVP---PPSAPPPKKSLGTQP 308
+ + SSS E S + ++Q+ P ++P P S K
Sbjct: 1029 PRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLR 1088
Query: 309 PKKAVEKQQPV---ESSEDSSDESDSSS--EEEKKPPTKAVVSKATTKPPPAKKAAESSS 363
K E QQ ESS+DS D SDSSS EE+ + P A + P P++ E+
Sbjct: 1089 KPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSR--TETLV 1146
Query: 364 DSSDSDSSEDDE-APSKPA-------GTTKNSSNKPAVTTK---SPAVKPAAAPKQPVGG 412
+ + ++SSEDD APS+ G T +S T K SP+V A K G
Sbjct: 1147 EETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDG 1206
Query: 413 GQKLLTRKA-----DSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSR 467
Q+ ++A + +E +S + +K++K + AL Q G
Sbjct: 1207 KQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQP 1266
Query: 468 DSSSDSDSSSS---------EEEEEK---TSKSAVKK----KPQKVAGGAAPSK-PASAK 510
+++ +S E+E +K T+K + +K + +K++G ++ P S K
Sbjct: 1267 WPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKK 1326
Query: 511 KGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEK 570
K K + + S E+ KGK + + + AK+ EEE +K
Sbjct: 1327 KKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQK 1386
Query: 571 KKAAVV---VSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNT----FPKRKKGEKR 620
V S S K++K+++ K+ + + KK K + +T P +KK +K+
Sbjct: 1387 GMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKK 1443
Score = 63.9 bits (154), Expect = 5e-10
Identities = 73/300 (24%), Positives = 121/300 (40%), Gaps = 50/300 (16%)
Query: 355 AKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQ 414
AKK S S+ S E++EA ++ A T P + + + +V A P
Sbjct: 73 AKKTRVSDPISTSESSEEEEEAEAETAKAT------PRLASTNSSVLGADLP-------- 118
Query: 415 KLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSD 474
SS +E + +E EK K + AT K +L + ++P+ S + S+++
Sbjct: 119 ----------SSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
Query: 475 SSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKG--KAESSNSSSSDDSSEEEEEK 532
S EEE G+ P+ A+AK G A ++SSS D SS +E
Sbjct: 169 LVSETEEE-----------------GSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211
Query: 533 LKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAA 592
++GK S +P KA+ S + KAA + + + K G+L K+ A
Sbjct: 212 VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQV-----KGGALPPAKR--AK 264
Query: 593 KEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAG 652
K E ++ + ++ P + + +AS +VR + A G AG
Sbjct: 265 KPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAG 324
Score = 54.3 bits (129), Expect = 4e-07
Identities = 82/377 (21%), Positives = 143/377 (37%), Gaps = 81/377 (21%)
Query: 58 LKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEE----EEEVQGPPAKKAAVPAKRVG 113
L+ K+PE V + K SS DSEDSS+ EE+ +GP K+A VG
Sbjct: 1087 LRKPKLPE--------VQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL--VG 1136
Query: 114 LPPGKAAAKASESSSSEESSDDD---DEEDQKKQPVQKGVKP-QAKAAKAPPKKAKSSDS 169
P + E+++ ESS+DD + + G+ P ++A+KA PK S
Sbjct: 1137 PTPSRTETLVEETAA--ESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSV 1194
Query: 170 DSDSSSEDEPPKNQKPK-------ITPVT--VKAQTKAPPKPARAAPKIANGKAASS--- 217
S +++D+P Q+ K ++P T +A + P+ +R K A AS+
Sbjct: 1195 SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLAL 1254
Query: 218 ----------------------------------------SSSSSSSSSSDDSEEEK--- 234
++ SS +S + K
Sbjct: 1255 QSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSG 1314
Query: 235 ---AAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSS 291
AA TP+ KK++ A +A+ +P + S++S+ + ++ K G S
Sbjct: 1315 DQPAARTPRSK-KKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGS 1373
Query: 292 VPPPSAPPPK--KSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKAT 349
P + K +GT + E + + D +E+KK KA +
Sbjct: 1374 QGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSE 1433
Query: 350 TKPPPAKKAAESSSDSS 366
+ KK + +++ +
Sbjct: 1434 SPSQKKKKKKKKTAEQT 1450
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 149 bits (375), Expect = 1e-35
Identities = 209/798 (26%), Positives = 297/798 (37%), Gaps = 169/798 (21%)
Query: 1 MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKS 60
MA+A RR +L PL+ L A + + +G A +LLDIY+ W ++
Sbjct: 1 MAEARKRR----ELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQT 56
Query: 61 AKVPERKLQANGPVAKKAKKKASSS--DSEDSSEEEEEVQGPPAK--------------- 103
+++ RK +A A +AKK S + +SSEEEEE + AK
Sbjct: 57 SEL-GRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGA 115
Query: 104 --------KAAVPAKRVG-----LP---PGKAAAKASESSSSEESSDDDDEEDQKKQPVQ 147
KA ++ G +P GK A S +S++ + +
Sbjct: 116 DLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175
Query: 148 KGVKPQAKAAKAPPK-KAKSSDSDSD--SSSEDEPPKNQKPKITPVTVKAQT-------- 196
+G P AA P A +DS S+ SSS DE KP + P VKA +
Sbjct: 176 EGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPA 235
Query: 197 -KAPPKPAR---AAPKIANG------KAASSSSSSSSSSSSDDSEEE------------- 233
KA P P + P++ G +A S SS +SEEE
Sbjct: 236 RKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASE 295
Query: 234 -----KAAATPKKTVPKKQVVAKAPVKA--------ATTPTRKSSSSEDSSSDEEEE--- 277
+AA+ P K P K P KA A P S SS + SSD EEE
Sbjct: 296 KILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355
Query: 278 QKKPMKNK-PGPYSSVPPPSAP---PPKKSLGTQPPKK---AVEKQQPVESSEDSSDESD 330
K ++ K G S V SAP P+K PP K AV K Q + EDS S+
Sbjct: 356 AKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSE 415
Query: 331 SSSEEEKKP-----------------PTKAVVSKATTKPPP------------AKKAAES 361
S EE+ P P K K PP K+ +S
Sbjct: 416 ESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDS 475
Query: 362 SSDSSDSDSSED-----DEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKL 416
S S +SDS + + A KP G K+ KPA T + A P P G
Sbjct: 476 RSSSEESDSDREALAAMNAAQVKPLG--KSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT 533
Query: 417 LTRKA-----DSSSSEEESSSSEEEKTKKMVATTKPKATAK----AALSLPAKQAPQGS- 466
+ + DS SS EESS S + + VA + K+ S PAK PQ +
Sbjct: 534 PSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
Query: 467 -------------RDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGK 513
SS+ S S++ EE + +A + KP P A KK
Sbjct: 594 PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL----KIPQTKACPKKTN 649
Query: 514 AESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKA 573
+S + + K SP +P G + A++ +++ S + EEEK
Sbjct: 650 TTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES-DSEEEKTGL 708
Query: 574 AVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEI 633
AV V ++ S+ K Q K A P + T P + + P + E
Sbjct: 709 AVTVGQAKSVGKGLQ---VKAASVPVKGSLGQGTAPVLPGK-------TGPTVTQVKAEK 758
Query: 634 EVDSRVADNSFDAKRGAA 651
+ DS ++ D++ AA
Sbjct: 759 QEDSESSEEESDSEEAAA 776
Score = 143 bits (360), Expect = 6e-34
Identities = 200/753 (26%), Positives = 277/753 (36%), Gaps = 196/753 (26%)
Query: 73 PVAKKAKKKASSSDS-EDSSEEEEEVQGPP------------AKKAAVPAK------RVG 113
P AK+AKK S+S E+ SE EEE + A+ PAK
Sbjct: 258 PPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATP 317
Query: 114 LPPGKAAAKASES----------SSSEESSDDDDEEDQKKQPVQKGVK------------ 151
PPGKA A AS++ SSSEESSD ++E K +Q
Sbjct: 318 APPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAP 377
Query: 152 ----PQAKAAKAPPKKA--------------KSSDSDSDSSSEDEPPKNQKPKITPVTVK 193
P+ AA APP K S S +S SE+E P KP V+
Sbjct: 378 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVR 437
Query: 194 AQT----KAPPKPARAAPKIANGKAASS----SSSSSSSSSSDDSEEEKAAATPKKTVPK 245
A + ++P K A AP G AA+ S SSS++S+ ++ A
Sbjct: 438 AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQV 497
Query: 246 KQVVAKAPVKAATT-------------PTRKSSSSEDSSSD---EEEEQKKPMKNKPGPY 289
K + VK A+T P K + S+ EE+ + ++
Sbjct: 498 KPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSD 557
Query: 290 SSVPPPSAPPPKKSLGT------------QPPKKA------VEKQQPVESSEDSSDESDS 331
VP AP +KSLG PP+KA V+ ++P+++SE S + SDS
Sbjct: 558 GEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS 617
Query: 332 SSEEE--------------KKPPTKAVVSKATT----KPPPAK----------------- 356
+ EE K P TKA K T K P +
Sbjct: 618 ADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAG 677
Query: 357 ----------KAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPA--- 403
+ AE SS S +SDS E+ + G K+ V S VK +
Sbjct: 678 SSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737
Query: 404 -AAPKQPVGGGQKLLTRKA----DSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLP 458
AP P G + KA DS SSEEES S E + V T+ K AKA +
Sbjct: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKA--NPA 795
Query: 459 AKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVK---KKPQK-----------VAGGAAPS 504
A +AP S+ ++ + ++ S S VK + PQ + G A +
Sbjct: 796 AARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 855
Query: 505 KPASAKKGKAESSNSSSSDDSSEEEEEKL-----------------KGKGSPR----PQA 543
A A+ G E S SS + SEEE E L K SPR P
Sbjct: 856 TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP 915
Query: 544 PKANGTSALTAQNGK---AAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQA 600
P G SA AQ GK + +SEE + + + A V S + + P A
Sbjct: 916 PGKTGPSA--AQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAA 973
Query: 601 KKIKLQTPNTFPKRKKGEKRASSPFRRVREEEI 633
+ Q +T K + E A S +E++
Sbjct: 974 TPAQAQAASTPRKARASESTARSSSSESEDEDV 1006
Score = 138 bits (348), Expect = 2e-32
Identities = 176/677 (25%), Positives = 244/677 (36%), Gaps = 161/677 (23%)
Query: 67 KLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASES 126
K AN K +K A S + E EE + +VPA PG +A ++S
Sbjct: 146 KTVANLLSGKSPRKSAEPSANTTLVSETEE-------EGSVPAFGAAAKPGMVSAGQADS 198
Query: 127 SSSEESSDDDDEEDQ-----------------KKQPVQKG---------VKPQAKAAKAP 160
SS + SS D+ + + K+ P +K V PQ K P
Sbjct: 199 SSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALP 258
Query: 161 P-KKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTK--------APPK--PARAAPKI 209
P K+AK + +S+SS E + + P T VKA K AP K P + A
Sbjct: 259 PAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPA 318
Query: 210 ANGKAASSSS----------SSSSSSSSDDSEEEK-------------------AAATPK 240
GKA + +S S SSS S DSEEE AA+ P
Sbjct: 319 PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA 378
Query: 241 KTVPKKQVVAKAPVKAATTPTR---------KSSSSEDSSSDEEEEQKKPMKNKPGPYSS 291
K P+K P K + SSSE+S S+EE + K +
Sbjct: 379 KESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438
Query: 292 VPPPSAPPPKKSLGTQPPKKA------VEKQQPVESSEDSSDESDSSSEE---------- 335
P+ P+K PP+K V+ + E S SS+ESDS E
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
Query: 336 --EKKPPTKAV-------------------VSKATTKPPPAKKAAESSSDSSDSDSSEDD 374
K P K V AT K +S S S +S S D
Sbjct: 499 PLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG 558
Query: 375 EAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVG--GGQKLLTRKADSSSSEEESSS 432
E P+ A + S + P PA P Q G Q + D+S S EESS
Sbjct: 559 EVPTAVAPAQEKSLGN--ILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 433 SEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKK 492
S + + + A AA + PA + PQ + ++S++ + A +K
Sbjct: 617 SADSE--------EAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK 668
Query: 493 KPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEE----------KLKGKGSP--- 539
A A S PA A + + +SSSS++S EEE+ K GKG
Sbjct: 669 --AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKA 726
Query: 540 ----------RPQAPKANGTSALTAQNGKAAK-----NSEEEEEEKKKAAVVVSKSGSLK 584
+ AP G + T KA K +SEEE + ++ AA S+K
Sbjct: 727 ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVK 786
Query: 585 KRKQNEAAKEAETPQAK 601
K + A P AK
Sbjct: 787 KTQAKANPAAARAPSAK 803
Score = 123 bits (309), Expect = 5e-28
Identities = 161/624 (25%), Positives = 253/624 (40%), Gaps = 90/624 (14%)
Query: 79 KKKASSSDSEDSSEEEEEV--QGPPAKK------AAVPAKR------VGLPPGKA----- 119
++ + SS+ E SEEE E Q P+ K A PAK PPGK
Sbjct: 865 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 924
Query: 120 -AAKASESSSSEESSDDDDEE-----------------DQKKQPVQKGVKPQAKAAKAPP 161
A K +S SS E SD D E D + P P A + P
Sbjct: 925 QAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP 984
Query: 162 KKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSS 221
+KA++S+S + SSS + ++ P +T +T P A P+IA + + +SSS
Sbjct: 985 RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPT-AHPRIAPKASMAGASSS 1043
Query: 222 SSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKP 281
SS D ++++ AT V KK A P+ A +SE +
Sbjct: 1044 KESSRISDGKKQEGPATQ---VSKKNP-ASLPLTQAALKVLAQKASEAQPPVARTQPSSG 1099
Query: 282 MKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPV---ESSEDSSDESDSSS--EEE 336
+ + G + P S K K E QQ ESS+DS D SDSSS EE+
Sbjct: 1100 VDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEED 1159
Query: 337 KKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDE-APSKPA-------GTTKNSS 388
+ P A S T P P++ E+ + + ++SSEDD APS+ G T +S
Sbjct: 1160 GEGPQGAK-SAHTLGPTPSR--TETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANS 1216
Query: 389 NKPAVTTK---SPAVKPAAAPKQPVGGGQKLLTRKA-----DSSSSEEESSSSEEEKTKK 440
T K SP+V A K G Q+ ++A + +E +S + +K++K
Sbjct: 1217 QASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRK 1276
Query: 441 MVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSS---------EEEEEK---TSKS 488
+ AL Q G +++ +S E+E +K T+K
Sbjct: 1277 PKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKE 1336
Query: 489 AVKK----KPQKVAGGAAPSK-PASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQA 543
+ +K + +K++G ++ P S KK K + + S E+ KGK +
Sbjct: 1337 SSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKAS 1396
Query: 544 PKANGTSALTAQNGKAAKNSEEEEEEKKKAAVV---VSKSGSLKKRKQNEAAKEAETPQA 600
+ + AK+ EEE +K V S S K++K+++ K+ + +
Sbjct: 1397 GDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKE 1456
Query: 601 KKIKLQTPNT----FPKRKKGEKR 620
KK K + +T P +KK +K+
Sbjct: 1457 KKKKAKKASTKDSESPSQKKKKKK 1480
Score = 105 bits (261), Expect = 2e-22
Identities = 174/711 (24%), Positives = 271/711 (38%), Gaps = 142/711 (19%)
Query: 60 SAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPP--G 117
+A+ P K + P K A+ + S+ + V+ P + + V A+ P G
Sbjct: 796 AARAPSAKGTISAP--GKVVTAAAQAKQRSPSKVKPPVRNP--QNSTVLARGPASVPSVG 851
Query: 118 KAAAKASE--------SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAK---- 165
KA A A++ S SSEE SD ++E + Q G Q +AA AP K++
Sbjct: 852 KAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGA 911
Query: 166 ---------------SSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPP--------KP 202
DS SSSE+ + P AQ PP P
Sbjct: 912 APTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPA---AVTSAQVIKPPLIFVDPNRSP 968
Query: 203 ARAAPKIANGKAASS------SSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKA 256
A A A +AAS+ S S++ SSSS+ +E+ AT T + V P
Sbjct: 969 AGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMP--T 1026
Query: 257 ATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVP---PPSAPPPKKSLGTQPPKKAV 313
A +S +SS +E + K + GP + V P S P + +L +KA
Sbjct: 1027 AHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVL-AQKAS 1085
Query: 314 EKQQPVESSEDSSD-ESDSSSEEEKKPPTKAVVSKATTK--------PPPAKKAAESSSD 364
E Q PV ++ SS +S + P + +V +K T K A KA ESS D
Sbjct: 1086 EAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDD 1145
Query: 365 SSDS--DSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQP---VGGGQKLLTR 419
S DS SS +E P G + P + V+ AA V Q LL+
Sbjct: 1146 SEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSG 1205
Query: 420 KADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSE 479
+ S +S+ AT K ++ + +L AK P G +++
Sbjct: 1206 YMTPGLTPANSQASK--------ATPKLDSSPSVSSTLAAKDDPDGKQEA---------- 1247
Query: 480 EEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSP 539
KPQ+ AG +P K G E+++ ++ S + + KG G+P
Sbjct: 1248 -------------KPQQAAGMLSP------KTGGKEAASGTTPQKSRKPK----KGAGNP 1284
Query: 540 RPQ--APKANGTSALTAQ---------NGKAAKNSEEEEEEKKKAAVVVSKSGSLK---- 584
+ A ++N T L Q K E E+++K V +K S K
Sbjct: 1285 QASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWES 1344
Query: 585 -KRKQNEAAKEAETPQAKK-------------IKLQTPNTFPKRKKGEKRASSPFRRVRE 630
KRK + A TP++KK + + +T K K +AS + +
Sbjct: 1345 RKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKG 1404
Query: 631 EEIEVDSRVADNSFDAKRGAAG--DWGERANQVLKFTKGKSFRHEKTKKKR 679
+ D + + G + G+++N K K KS + +K K+K+
Sbjct: 1405 KGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKK 1455
Score = 63.9 bits (154), Expect = 5e-10
Identities = 73/300 (24%), Positives = 121/300 (40%), Gaps = 50/300 (16%)
Query: 355 AKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQ 414
AKK S S+ S E++EA ++ A T P + + + +V A P
Sbjct: 73 AKKTRVSDPISTSESSEEEEEAEAETAKAT------PRLASTNSSVLGADLP-------- 118
Query: 415 KLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSD 474
SS +E + +E EK K + AT K +L + ++P+ S + S+++
Sbjct: 119 ----------SSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
Query: 475 SSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKG--KAESSNSSSSDDSSEEEEEK 532
S EEE G+ P+ A+AK G A ++SSS D SS +E
Sbjct: 169 LVSETEEE-----------------GSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211
Query: 533 LKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAA 592
++GK S +P KA+ S + KAA + + + K G+L K+ A
Sbjct: 212 VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQV-----KGGALPPAKR--AK 264
Query: 593 KEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAG 652
K E ++ + ++ P + + +AS +VR + A G AG
Sbjct: 265 KPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAG 324
Score = 53.9 bits (128), Expect = 5e-07
Identities = 81/377 (21%), Positives = 143/377 (37%), Gaps = 82/377 (21%)
Query: 58 LKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEE----EEEVQGPPAKKAAVPAKRVG 113
L+ K+PE V + K SS DSEDSS+ EE+ +GP K+A +G
Sbjct: 1125 LRKPKLPE--------VQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSA---HTLG 1173
Query: 114 LPPGKAAAKASESSSSEESSDDD---DEEDQKKQPVQKGVKP-QAKAAKAPPKKAKSSDS 169
P + E+++ ESS+DD + + G+ P ++A+KA PK S
Sbjct: 1174 PTPSRTETLVEETAA--ESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSV 1231
Query: 170 DSDSSSEDEPPKNQKPK-------ITPVT--VKAQTKAPPKPARAAPKIANGKAASS--- 217
S +++D+P Q+ K ++P T +A + P+ +R K A AS+
Sbjct: 1232 SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLAL 1291
Query: 218 ----------------------------------------SSSSSSSSSSDDSEEEK--- 234
++ SS +S + K
Sbjct: 1292 QSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSG 1351
Query: 235 ---AAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSS 291
AA TP+ KK++ A +A+ +P + S++S+ + ++ K G S
Sbjct: 1352 DQPAARTPRSK-KKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGS 1410
Query: 292 VPPPSAPPPK--KSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKAT 349
P + K +GT + E + + D +E+KK KA +
Sbjct: 1411 QGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSE 1470
Query: 350 TKPPPAKKAAESSSDSS 366
+ KK + +++ +
Sbjct: 1471 SPSQKKKKKKKKTAEQT 1487
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 149 bits (375), Expect = 1e-35
Identities = 209/798 (26%), Positives = 297/798 (37%), Gaps = 169/798 (21%)
Query: 1 MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKS 60
MA+A RR +L PL+ L A + + +G A +LLDIY+ W ++
Sbjct: 1 MAEARKRR----ELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQT 56
Query: 61 AKVPERKLQANGPVAKKAKKKASSS--DSEDSSEEEEEVQGPPAK--------------- 103
+++ RK +A A +AKK S + +SSEEEEE + AK
Sbjct: 57 SEL-GRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGA 115
Query: 104 --------KAAVPAKRVG-----LP---PGKAAAKASESSSSEESSDDDDEEDQKKQPVQ 147
KA ++ G +P GK A S +S++ + +
Sbjct: 116 DLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175
Query: 148 KGVKPQAKAAKAPPK-KAKSSDSDSD--SSSEDEPPKNQKPKITPVTVKAQT-------- 196
+G P AA P A +DS S+ SSS DE KP + P VKA +
Sbjct: 176 EGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPA 235
Query: 197 -KAPPKPAR---AAPKIANG------KAASSSSSSSSSSSSDDSEEE------------- 233
KA P P + P++ G +A S SS +SEEE
Sbjct: 236 RKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASE 295
Query: 234 -----KAAATPKKTVPKKQVVAKAPVKA--------ATTPTRKSSSSEDSSSDEEEE--- 277
+AA+ P K P K P KA A P S SS + SSD EEE
Sbjct: 296 KILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355
Query: 278 QKKPMKNK-PGPYSSVPPPSAP---PPKKSLGTQPPKK---AVEKQQPVESSEDSSDESD 330
K ++ K G S V SAP P+K PP K AV K Q + EDS S+
Sbjct: 356 AKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSE 415
Query: 331 SSSEEEKKP-----------------PTKAVVSKATTKPPP------------AKKAAES 361
S EE+ P P K K PP K+ +S
Sbjct: 416 ESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDS 475
Query: 362 SSDSSDSDSSED-----DEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKL 416
S S +SDS + + A KP G K+ KPA T + A P P G
Sbjct: 476 RSSSEESDSDREALAAMNAAQVKPLG--KSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT 533
Query: 417 LTRKA-----DSSSSEEESSSSEEEKTKKMVATTKPKATAK----AALSLPAKQAPQGS- 466
+ + DS SS EESS S + + VA + K+ S PAK PQ +
Sbjct: 534 PSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
Query: 467 -------------RDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGK 513
SS+ S S++ EE + +A + KP P A KK
Sbjct: 594 PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL----KIPQTKACPKKTN 649
Query: 514 AESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKA 573
+S + + K SP +P G + A++ +++ S + EEEK
Sbjct: 650 TTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES-DSEEEKTGL 708
Query: 574 AVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEI 633
AV V ++ S+ K Q K A P + T P + + P + E
Sbjct: 709 AVTVGQAKSVGKGLQ---VKAASVPVKGSLGQGTAPVLPGK-------TGPTVTQVKAEK 758
Query: 634 EVDSRVADNSFDAKRGAA 651
+ DS ++ D++ AA
Sbjct: 759 QEDSESSEEESDSEEAAA 776
Score = 138 bits (348), Expect = 2e-32
Identities = 176/677 (25%), Positives = 244/677 (36%), Gaps = 161/677 (23%)
Query: 67 KLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASES 126
K AN K +K A S + E EE + +VPA PG +A ++S
Sbjct: 146 KTVANLLSGKSPRKSAEPSANTTLVSETEE-------EGSVPAFGAAAKPGMVSAGQADS 198
Query: 127 SSSEESSDDDDEEDQ-----------------KKQPVQKG---------VKPQAKAAKAP 160
SS + SS D+ + + K+ P +K V PQ K P
Sbjct: 199 SSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALP 258
Query: 161 P-KKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTK--------APPK--PARAAPKI 209
P K+AK + +S+SS E + + P T VKA K AP K P + A
Sbjct: 259 PAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPA 318
Query: 210 ANGKAASSSS----------SSSSSSSSDDSEEEK-------------------AAATPK 240
GKA + +S S SSS S DSEEE AA+ P
Sbjct: 319 PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA 378
Query: 241 KTVPKKQVVAKAPVKAATTPTR---------KSSSSEDSSSDEEEEQKKPMKNKPGPYSS 291
K P+K P K + SSSE+S S+EE + K +
Sbjct: 379 KESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438
Query: 292 VPPPSAPPPKKSLGTQPPKKA------VEKQQPVESSEDSSDESDSSSEE---------- 335
P+ P+K PP+K V+ + E S SS+ESDS E
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
Query: 336 --EKKPPTKAV-------------------VSKATTKPPPAKKAAESSSDSSDSDSSEDD 374
K P K V AT K +S S S +S S D
Sbjct: 499 PLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG 558
Query: 375 EAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVG--GGQKLLTRKADSSSSEEESSS 432
E P+ A + S + P PA P Q G Q + D+S S EESS
Sbjct: 559 EVPTAVAPAQEKSLGN--ILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 433 SEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKK 492
S + + + A AA + PA + PQ + ++S++ + A +K
Sbjct: 617 SADSE--------EAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK 668
Query: 493 KPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEE----------KLKGKGSP--- 539
A A S PA A + + +SSSS++S EEE+ K GKG
Sbjct: 669 --AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKA 726
Query: 540 ----------RPQAPKANGTSALTAQNGKAAK-----NSEEEEEEKKKAAVVVSKSGSLK 584
+ AP G + T KA K +SEEE + ++ AA S+K
Sbjct: 727 ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVK 786
Query: 585 KRKQNEAAKEAETPQAK 601
K + A P AK
Sbjct: 787 KTQAKANPAAARAPSAK 803
Score = 138 bits (348), Expect = 2e-32
Identities = 184/662 (27%), Positives = 254/662 (38%), Gaps = 173/662 (26%)
Query: 73 PVAKKAKKKASSSDS-EDSSEEEEEVQGPP------------AKKAAVPAK------RVG 113
P AK+AKK S+S E+ SE EEE + A+ PAK
Sbjct: 258 PPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATP 317
Query: 114 LPPGKAAAKASES----------SSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKK 163
PPGKA A AS++ SSSEESSD ++E P AKA
Sbjct: 318 APPGKAGAVASQTKAGKPEEDSESSSEESSDSEEET------------PAAKALLQAKAS 365
Query: 164 AKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSS 223
K+S + S+ E P+ + AP P + P +A +A S S
Sbjct: 366 GKTSQVGAASAPAKESPR-------------KGAAPAPPGKTGPAVAKAQAGKREEDSQS 412
Query: 224 SSSSDDSEEEKAA-ATPKKTVPKKQVVAKAPVK------AATTPTRKS------------ 264
SS DSEEE A A P P+ + A AP K AA P RK+
Sbjct: 413 SSEESDSEEEAPAQAKPSGKAPQVRA-ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQ 471
Query: 265 -----SSSEDSSSDEEE------EQKKPMKN----KPGPYSSVPP---PSAPPPKKSLGT 306
SSSE+S SD E Q KP+ KP + P + P P +G
Sbjct: 472 EEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGP 531
Query: 307 QPPKKAVEKQQPVESSEDSSDESDSSSEEE--------------------------KKPP 340
P V K + E SE SS+ES SS+ E K PP
Sbjct: 532 ATPSAQVGKWE--EDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPP 589
Query: 341 TKA---VVSKATTKPPPAKKAAESSSDSSDSDSSED--DEAPSKPA-------------G 382
KA V KP +++E SSDS+DS+ + A +KPA
Sbjct: 590 QKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTN 649
Query: 383 TTKNSSNKPA-VTTKSP-----AVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEE 436
TT ++ P V T++P A PA + GG Q R A+ SSS EES S EEE
Sbjct: 650 TTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ----RPAEDSSSSEESDS-EEE 704
Query: 437 KTKKMVATTKPKATAKA------------------ALSLPAKQAP---QGSRDSSSDSDS 475
KT V + K+ K A LP K P Q + DS+S
Sbjct: 705 KTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSES 764
Query: 476 SSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKG 535
S E + E+ + S + K V A + PA+A+ A+ + S+ + + K +
Sbjct: 765 SEEESDSEEAAASPAQVKTS-VKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRS 823
Query: 536 KGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEA 595
+P P N ++ G A+ S + A + S +++++ +EA
Sbjct: 824 PSKVKP--PVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881
Query: 596 ET 597
ET
Sbjct: 882 ET 883
Score = 131 bits (329), Expect = 2e-30
Identities = 161/591 (27%), Positives = 215/591 (36%), Gaps = 104/591 (17%)
Query: 61 AKVPERKLQANGPVA---KKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPG 117
AK P +K GPVA K K +S SE+SS+ + + P A AA + +P
Sbjct: 585 AKGPPQKA---GPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT 641
Query: 118 KAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPP-------------KKA 164
KA K + +++S K PV+ G + KA A + A
Sbjct: 642 KACPKKTNTTASA-----------KVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA 690
Query: 165 KSSDSDSDSSSEDEPP-------------KNQKPKITPVTVKA---QTKAPPKPARAAPK 208
+ S S +S SE+E K + K V VK Q AP P + P
Sbjct: 691 EDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPT 750
Query: 209 IANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSE 268
+ KA S SS SD E + A K +V K Q AKA AA P+ K + S
Sbjct: 751 VTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQ--AKANPAAARAPSAKGTISA 808
Query: 269 DS---SSDEEEEQKKPMKNKP---GPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESS 322
++ + +Q+ P K KP P +S P S+G A + P E S
Sbjct: 809 PGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDS 868
Query: 323 EDSSDESDSSSEEEK----KP------------PTKAVVSKATTKPPPAKK----AAESS 362
S +ESDS E E KP P K K PP K A
Sbjct: 869 GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK 928
Query: 363 SDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKAD 422
D S S S E D PA T KP + P PA P RKA
Sbjct: 929 QDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKAR 988
Query: 423 SSSSEEESSSSEEEKTKKMVAT------------TKPKATAKAALSLPAKQAPQGSRDSS 470
+S S SSSSE E + AT T P A + A A S++SS
Sbjct: 989 ASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGA-SSSKESS 1047
Query: 471 SDSDSSSSEEEEEKT-------------SKSAVKKKPQKVAGGAAP--SKPASAKKGKAE 515
SD E + S S K K+ P + A + +
Sbjct: 1048 RISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDD 1107
Query: 516 SSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEE 566
S +SS S SEE+ E +G S P + T L + AA++SE++
Sbjct: 1108 SEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEET--AAESSEDD 1156
Score = 111 bits (278), Expect = 2e-24
Identities = 166/657 (25%), Positives = 263/657 (40%), Gaps = 106/657 (16%)
Query: 60 SAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPP--G 117
+A+ P K + P K A+ + S+ + V+ P + + V A+ P G
Sbjct: 796 AARAPSAKGTISAP--GKVVTAAAQAKQRSPSKVKPPVRNP--QNSTVLARGPASVPSVG 851
Query: 118 KAAAKASE--------SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAK---- 165
KA A A++ S SSEE SD ++E + Q G Q +AA AP K++
Sbjct: 852 KAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGA 911
Query: 166 ---------------SSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPP--------KP 202
DS SSSE+ + P AQ PP P
Sbjct: 912 APTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPA---AVTSAQVIKPPLIFVDPNRSP 968
Query: 203 ARAAPKIANGKAASS------SSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAP--- 253
A A A +AAS+ S S++ SSSS+ +E+ AT T + V P
Sbjct: 969 AGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAH 1028
Query: 254 --VKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVP---PPSAPPPKKSLGTQP 308
+ + SSS E S + ++Q+ P ++P P S K
Sbjct: 1029 PRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLR 1088
Query: 309 PKKAVEKQQPV---ESSEDSSDESDSSS--EEEKKPPTKAVVSKATTKPPPAKKAAESSS 363
K E QQ ESS+DS D SDSSS EE+ + P A S T P P++ E+
Sbjct: 1089 KPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAK-SAHTLGPTPSR--TETLV 1145
Query: 364 DSSDSDSSEDDE-APSKPA-------GTTKNSSNKPAVTTK---SPAVKPAAAPKQPVGG 412
+ + ++SSEDD APS+ G T +S T K SP+V A K G
Sbjct: 1146 EETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDG 1205
Query: 413 GQKLLTRKA-----DSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSR 467
Q+ ++A + +E +S + +K++K + AL Q G
Sbjct: 1206 KQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQP 1265
Query: 468 DSSSDSDSSSS---------EEEEEK---TSKSAVKK----KPQKVAGGAAPSK-PASAK 510
+++ +S E+E +K T+K + +K + +K++G ++ P S K
Sbjct: 1266 WPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKK 1325
Query: 511 KGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEK 570
K K + + S E+ KGK + + + AK+ EEE +K
Sbjct: 1326 KKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQK 1385
Query: 571 KKAAVV---VSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNT----FPKRKKGEKR 620
V S S K++K+++ K+ + + KK K + +T P +KK +K+
Sbjct: 1386 GMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKK 1442
Score = 111 bits (278), Expect = 2e-24
Identities = 148/599 (24%), Positives = 231/599 (38%), Gaps = 99/599 (16%)
Query: 79 KKKASSSDSEDSSEEEEEV--QGPPAKK------AAVPAKR------VGLPPGKA----- 119
++ + SS+ E SEEE E Q P+ K A PAK PPGK
Sbjct: 865 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 924
Query: 120 -AAKASESSSSEESSDDDDEE-----------------DQKKQPVQKGVKPQAKAAKAPP 161
A K +S SS E SD D E D + P P A + P
Sbjct: 925 QAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP 984
Query: 162 KKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSS 221
+KA++S+S + SSS + ++ P +T +T P A P+IA + + +SSS
Sbjct: 985 RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPT-AHPRIAPKASMAGASSS 1043
Query: 222 SSSSSSDDSEEEKAAAT---------PKKTVPKKQVVAKAP--VKAATTPTRKSSSSEDS 270
SS D ++++ AT P + V AK ++ P + ++
Sbjct: 1044 KESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPE 1103
Query: 271 SSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPK-KAVEKQQPVESSEDSSDES 329
SSD+ E+ + G P +LG P + + + ++ ESSED
Sbjct: 1104 SSDDSEDSSD---SSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAP 1160
Query: 330 DSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKP--------- 380
S P + +K P ++ S S + + D + +KP
Sbjct: 1161 SQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSP 1220
Query: 381 --------AGTTKNSSNKPAVTTKSPAVKPAAAPK---QPVGGGQKLLTRKADSSSSEEE 429
+GTT S KP +P A Q + G L +S +
Sbjct: 1221 KTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKV 1280
Query: 430 SSSSEEEKTKKMVATTKPKA-----TAKAALS--LPAKQAPQGSRD----SSSDSDSSSS 478
+ E++ KK+V TTK + + K LS PA + P+ + + ++S S
Sbjct: 1281 LTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVS 1340
Query: 479 EEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGS 538
E+ TSK K K K +G KKGK + + D E EEE KG G+
Sbjct: 1341 PEKTSTTSKG--KAKRDKASGDV------KEKKGKGSLGSQGAKD---EPEEELQKGMGT 1389
Query: 539 PRPQAPKANGTSALTAQNGKAAKNSEEEEEEK---KKAAVVVSKSGSLKKRKQNEAAKE 594
++N S + K +E++E+K KKA+ S+S S KK+K+ + E
Sbjct: 1390 VEG-GDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAE 1447
Score = 68.6 bits (166), Expect = 2e-11
Identities = 94/461 (20%), Positives = 167/461 (36%), Gaps = 77/461 (16%)
Query: 70 ANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKA-----AVPA--------------- 109
A+ +A KA +SS E S + + Q PA + +PA
Sbjct: 1027 AHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNK 1086
Query: 110 -KRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSD 168
++ LP + A KA ESS E S D ++ +G K P + +
Sbjct: 1087 LRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVE 1146
Query: 169 SDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSD 228
+ SSED+ + ++ T A + ++A PK+ SS S SS+ ++ D
Sbjct: 1147 ETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKL-----DSSPSVSSTLAAKD 1201
Query: 229 DSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGP 288
D + ++ A P +AA + K+ E +S ++ +KP K P
Sbjct: 1202 DPDGKQEA---------------KPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNP 1246
Query: 289 YSSVPPPSAPPPKKSLGTQPPKKAVEKQQPV------------ESSEDSSDESDSSSEEE 336
+S + + LG P + Q V + D++ ES E
Sbjct: 1247 QASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWES 1306
Query: 337 KK-------PPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSN 389
+K P + SK K + S S S +S+ K +G K
Sbjct: 1307 RKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKG 1366
Query: 390 KPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKA 449
K ++ ++ +P ++ +G D S+ + + + +K KK + K
Sbjct: 1367 KGSLGSQGAKDEPEEELQKGMG-----TVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKK 1421
Query: 450 TAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAV 490
AK A + S+S S +++++KT++ V
Sbjct: 1422 KAKKAST------------KDSESPSQKKKKKKKKTAEQTV 1450
Score = 63.9 bits (154), Expect = 5e-10
Identities = 73/300 (24%), Positives = 121/300 (40%), Gaps = 50/300 (16%)
Query: 355 AKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQ 414
AKK S S+ S E++EA ++ A T P + + + +V A P
Sbjct: 73 AKKTRVSDPISTSESSEEEEEAEAETAKAT------PRLASTNSSVLGADLP-------- 118
Query: 415 KLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSD 474
SS +E + +E EK K + AT K +L + ++P+ S + S+++
Sbjct: 119 ----------SSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
Query: 475 SSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKG--KAESSNSSSSDDSSEEEEEK 532
S EEE G+ P+ A+AK G A ++SSS D SS +E
Sbjct: 169 LVSETEEE-----------------GSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211
Query: 533 LKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAA 592
++GK S +P KA+ S + KAA + + + K G+L K+ A
Sbjct: 212 VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQV-----KGGALPPAKR--AK 264
Query: 593 KEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAG 652
K E ++ + ++ P + + +AS +VR + A G AG
Sbjct: 265 KPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAG 324
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 149 bits (375), Expect = 1e-35
Identities = 209/798 (26%), Positives = 297/798 (37%), Gaps = 169/798 (21%)
Query: 1 MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKS 60
MA+A RR +L PL+ L A + + +G A +LLDIY+ W ++
Sbjct: 1 MAEARKRR----ELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQT 56
Query: 61 AKVPERKLQANGPVAKKAKKKASSS--DSEDSSEEEEEVQGPPAK--------------- 103
+++ RK +A A +AKK S + +SSEEEEE + AK
Sbjct: 57 SEL-GRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGA 115
Query: 104 --------KAAVPAKRVG-----LP---PGKAAAKASESSSSEESSDDDDEEDQKKQPVQ 147
KA ++ G +P GK A S +S++ + +
Sbjct: 116 DLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175
Query: 148 KGVKPQAKAAKAPPK-KAKSSDSDSD--SSSEDEPPKNQKPKITPVTVKAQT-------- 196
+G P AA P A +DS S+ SSS DE KP + P VKA +
Sbjct: 176 EGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPA 235
Query: 197 -KAPPKPAR---AAPKIANG------KAASSSSSSSSSSSSDDSEEE------------- 233
KA P P + P++ G +A S SS +SEEE
Sbjct: 236 RKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASE 295
Query: 234 -----KAAATPKKTVPKKQVVAKAPVKA--------ATTPTRKSSSSEDSSSDEEEE--- 277
+AA+ P K P K P KA A P S SS + SSD EEE
Sbjct: 296 KILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355
Query: 278 QKKPMKNK-PGPYSSVPPPSAP---PPKKSLGTQPPKK---AVEKQQPVESSEDSSDESD 330
K ++ K G S V SAP P+K PP K AV K Q + EDS S+
Sbjct: 356 AKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSE 415
Query: 331 SSSEEEKKP-----------------PTKAVVSKATTKPPP------------AKKAAES 361
S EE+ P P K K PP K+ +S
Sbjct: 416 ESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDS 475
Query: 362 SSDSSDSDSSED-----DEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKL 416
S S +SDS + + A KP G K+ KPA T + A P P G
Sbjct: 476 RSSSEESDSDREALAAMNAAQVKPLG--KSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT 533
Query: 417 LTRKA-----DSSSSEEESSSSEEEKTKKMVATTKPKATAK----AALSLPAKQAPQGS- 466
+ + DS SS EESS S + + VA + K+ S PAK PQ +
Sbjct: 534 PSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
Query: 467 -------------RDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGK 513
SS+ S S++ EE + +A + KP P A KK
Sbjct: 594 PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL----KIPQTKACPKKTN 649
Query: 514 AESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKA 573
+S + + K SP +P G + A++ +++ S + EEEK
Sbjct: 650 TTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES-DSEEEKTGL 708
Query: 574 AVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEI 633
AV V ++ S+ K Q K A P + T P + + P + E
Sbjct: 709 AVTVGQAKSVGKGLQ---VKAASVPVKGSLGQGTAPVLPGK-------TGPTVTQVKAEK 758
Query: 634 EVDSRVADNSFDAKRGAA 651
+ DS ++ D++ AA
Sbjct: 759 QEDSESSEEESDSEEAAA 776
Score = 139 bits (351), Expect = 7e-33
Identities = 191/698 (27%), Positives = 260/698 (37%), Gaps = 196/698 (28%)
Query: 73 PVAKKAKKKASSSDS-EDSSEEEEEVQGPP------------AKKAAVPAK------RVG 113
P AK+AKK S+S E+ SE EEE + A+ PAK
Sbjct: 258 PPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATP 317
Query: 114 LPPGKAAAKASES----------SSSEESSDDDDEEDQKKQPVQKGVK------------ 151
PPGKA A AS++ SSSEESSD ++E K +Q
Sbjct: 318 APPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAP 377
Query: 152 ----PQAKAAKAPPKKA--------------KSSDSDSDSSSEDEPPKNQKPKITPVTVK 193
P+ AA APP K S S +S SE+E P KP V+
Sbjct: 378 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVR 437
Query: 194 AQT----KAPPKPARAAPKIANGKAASS----SSSSSSSSSSDDSEEEKAAATPKKTVPK 245
A + ++P K A AP G AA+ S SSS++S+ ++ A
Sbjct: 438 AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQV 497
Query: 246 KQVVAKAPVKAATT-------------PTRKSSSSEDSSSD---EEEEQKKPMKNKPGPY 289
K + VK A+T P K + S+ EE+ + ++
Sbjct: 498 KPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSD 557
Query: 290 SSVPPPSAPPPKKSLGT------------QPPKKA------VEKQQPVESSEDSSDESDS 331
VP AP +KSLG PP+KA V+ ++P+++SE S + SDS
Sbjct: 558 GEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS 617
Query: 332 SSEEE--------------KKPPTKAVVSKATT----KPPPAK----------------- 356
+ EE K P TKA K T K P +
Sbjct: 618 ADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAG 677
Query: 357 ----------KAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPA--- 403
+ AE SS S +SDS E+ + G K+ V S VK +
Sbjct: 678 SSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737
Query: 404 -AAPKQPVGGGQKLLTRKA----DSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLP 458
AP P G + KA DS SSEEES S E + V T+ K AKA +
Sbjct: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKA--NPA 795
Query: 459 AKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVK---KKPQK-----------VAGGAAPS 504
A +AP S+ ++ + ++ S S VK + PQ + G A +
Sbjct: 796 AARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 855
Query: 505 KPASAKKGKAESSNSSSSDDSSEEEEEKL-----------------KGKGSPR----PQA 543
A A+ G E S SS + SEEE E L K SPR P
Sbjct: 856 TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP 915
Query: 544 PKANGTSALTAQNGK---AAKNSEEEEEEKKKAAVVVS 578
P G SA AQ GK + +SEE + + + A V S
Sbjct: 916 PGKTGPSA--AQAGKQDDSGSSSEESDSDGEAPAAVTS 951
Score = 138 bits (348), Expect = 2e-32
Identities = 176/677 (25%), Positives = 244/677 (36%), Gaps = 161/677 (23%)
Query: 67 KLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASES 126
K AN K +K A S + E EE + +VPA PG +A ++S
Sbjct: 146 KTVANLLSGKSPRKSAEPSANTTLVSETEE-------EGSVPAFGAAAKPGMVSAGQADS 198
Query: 127 SSSEESSDDDDEEDQ-----------------KKQPVQKG---------VKPQAKAAKAP 160
SS + SS D+ + + K+ P +K V PQ K P
Sbjct: 199 SSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALP 258
Query: 161 P-KKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTK--------APPK--PARAAPKI 209
P K+AK + +S+SS E + + P T VKA K AP K P + A
Sbjct: 259 PAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPA 318
Query: 210 ANGKAASSSS----------SSSSSSSSDDSEEEK-------------------AAATPK 240
GKA + +S S SSS S DSEEE AA+ P
Sbjct: 319 PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA 378
Query: 241 KTVPKKQVVAKAPVKAATTPTR---------KSSSSEDSSSDEEEEQKKPMKNKPGPYSS 291
K P+K P K + SSSE+S S+EE + K +
Sbjct: 379 KESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438
Query: 292 VPPPSAPPPKKSLGTQPPKKA------VEKQQPVESSEDSSDESDSSSEE---------- 335
P+ P+K PP+K V+ + E S SS+ESDS E
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
Query: 336 --EKKPPTKAV-------------------VSKATTKPPPAKKAAESSSDSSDSDSSEDD 374
K P K V AT K +S S S +S S D
Sbjct: 499 PLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG 558
Query: 375 EAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVG--GGQKLLTRKADSSSSEEESSS 432
E P+ A + S + P PA P Q G Q + D+S S EESS
Sbjct: 559 EVPTAVAPAQEKSLGN--ILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 433 SEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKK 492
S + + + A AA + PA + PQ + ++S++ + A +K
Sbjct: 617 SADSE--------EAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK 668
Query: 493 KPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEE----------KLKGKGSP--- 539
A A S PA A + + +SSSS++S EEE+ K GKG
Sbjct: 669 --AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKA 726
Query: 540 ----------RPQAPKANGTSALTAQNGKAAK-----NSEEEEEEKKKAAVVVSKSGSLK 584
+ AP G + T KA K +SEEE + ++ AA S+K
Sbjct: 727 ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVK 786
Query: 585 KRKQNEAAKEAETPQAK 601
K + A P AK
Sbjct: 787 KTQAKANPAAARAPSAK 803
Score = 99.8 bits (247), Expect = 8e-21
Identities = 130/501 (25%), Positives = 175/501 (34%), Gaps = 132/501 (26%)
Query: 60 SAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVG------ 113
+A P RK GP A + + DS SSEE + + A A K +G
Sbjct: 451 AAPAPPRK---TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVK 507
Query: 114 ----------------LPPGKAAAKA-----------SESSSSEESSDDDDEEDQKKQPV 146
+PPGK SESSS E S D E P
Sbjct: 508 PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA 567
Query: 147 QKG-------VKPQAKAAKAPPKKA----------------KSSDSDSDSSSEDEPPKNQ 183
Q+ KP + AK PP+KA +SS+ SDS+ +E P
Sbjct: 568 QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAM 627
Query: 184 K----------------PKITPVTVKAQ-------TKAPPK------PARAAPKIANGKA 214
PK T T A+ T+AP K PA ++P +A G
Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687
Query: 215 ASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKA-PVKAATTPTR----------- 262
+ SSSS S DSEEEK TV + + V K VKAA+ P +
Sbjct: 688 RPAEDSSSSEES--DSEEEKTGLAV--TVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVL 743
Query: 263 -----------KSSSSEDSSSDEEEEQKKPMKNKPGPYSSV---------PPPSAPPPKK 302
K+ EDS S EEE + P + P + P K
Sbjct: 744 PGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAK 803
Query: 303 SLGTQPPK----KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKA 358
+ P K A KQ+ + +S+ + P + V KA A+
Sbjct: 804 GTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTG 863
Query: 359 AESSSDSSDSDSSEDDEAPS----KPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQ 414
E S SS+ +S ++EA + KP+G T A +SP A P G
Sbjct: 864 PEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSA 923
Query: 415 KLLTRKADSSSSEEESSSSEE 435
++ DS SS EES S E
Sbjct: 924 AQAGKQDDSGSSSEESDSDGE 944
Score = 63.9 bits (154), Expect = 5e-10
Identities = 73/300 (24%), Positives = 121/300 (40%), Gaps = 50/300 (16%)
Query: 355 AKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQ 414
AKK S S+ S E++EA ++ A T P + + + +V A P
Sbjct: 73 AKKTRVSDPISTSESSEEEEEAEAETAKAT------PRLASTNSSVLGADLP-------- 118
Query: 415 KLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSD 474
SS +E + +E EK K + AT K +L + ++P+ S + S+++
Sbjct: 119 ----------SSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
Query: 475 SSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKG--KAESSNSSSSDDSSEEEEEK 532
S EEE G+ P+ A+AK G A ++SSS D SS +E
Sbjct: 169 LVSETEEE-----------------GSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211
Query: 533 LKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAA 592
++GK S +P KA+ S + KAA + + + K G+L K+ A
Sbjct: 212 VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQV-----KGGALPPAKR--AK 264
Query: 593 KEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAG 652
K E ++ + ++ P + + +AS +VR + A G AG
Sbjct: 265 KPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAG 324
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 144 bits (363), Expect = 3e-34
Identities = 146/594 (24%), Positives = 240/594 (40%), Gaps = 73/594 (12%)
Query: 59 KSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEE-EEEVQGPPAKKAAVPAKRVGLPPG 117
+ +V E + AK+ + K E+ +E EEE + PPA++AA P K P
Sbjct: 462 EETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVK 521
Query: 118 KAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSED 177
+ A +E+ S E+ ++ K P + VK KA ++AKS
Sbjct: 522 EEAKSPAEAKSPEK--------EEAKSPAE--VKSPEKAKSPAKEEAKS----------- 560
Query: 178 EPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAA 237
PP+ + P+ A+ K+P K A + A A + S + S ++++ A
Sbjct: 561 -PPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAK 619
Query: 238 TPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNK-PGPYSSVPPPS 296
+P K K K+P KA + ++ S E + S E+EE K P K K P + P
Sbjct: 620 SPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK 679
Query: 297 APPPKKSLGTQPPK---------KAVEK-QQPVESSEDSSDESDSSSEEEKKPPTKA--V 344
A P K+ P K K+ EK + PV+ S +++ S +EE K P KA
Sbjct: 680 AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739
Query: 345 VSKATTKPPPAK----------KAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVT 394
V + P AK K+ E+ + + + S D+ P K K P
Sbjct: 740 VKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPE-K 798
Query: 395 TKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTK---KMVATTKPKATA 451
KSP + A AP +K + +K + S +E +E K K K K AT
Sbjct: 799 AKSPLKEDAKAP-------EKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATP 851
Query: 452 KAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGG---AAPSKPAS 508
K +K+ +++ E EK +S V+ K ++ P K A
Sbjct: 852 KTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAP 911
Query: 509 AKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEE 568
AK E + + +++E + K K +P A+ +AA ++ +E
Sbjct: 912 AKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKP------------AEKKEAAPEKKDTKE 959
Query: 569 EKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRAS 622
EK K K+ + K +KE P+A+K + ++ +T K K ++A+
Sbjct: 960 EKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAE-KSSSTDQKDSKPPEKAT 1012
Score = 142 bits (358), Expect = 1e-33
Identities = 137/525 (26%), Positives = 224/525 (42%), Gaps = 47/525 (8%)
Query: 61 AKVPERKLQANGPVAKKAKKKASSSDSEDS-------SEEEEEVQGPPAKKAAVPAKRVG 113
AK PE++ +A P K+ +KA S E++ S E+EE + P K+ AK
Sbjct: 530 AKSPEKE-EAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKS-- 586
Query: 114 LPPGKAAAKA-SESSSSEESSDDDDEEDQKKQPVQKGVKPQAK--AAKAPPKKAKSSDSD 170
P K AK+ +E+ S E++ EE + + VK +AK A P+KAKS +
Sbjct: 587 --PAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKE 644
Query: 171 SDSSSEDEPPKNQKPKITPVTVKAQTKAPPK-PARAAPKIANGKAASSSSSSSSSSSSDD 229
S E ++ +P K+ KA K P +A + KA + S + S ++
Sbjct: 645 EAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPV---KAEAKSPEKAKSPVKEE 701
Query: 230 SEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPY 289
++ + A +P K K AK+PVK K+ S + E+ K P K K
Sbjct: 702 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKT--- 758
Query: 290 SSVPPPSAPPPKKSLGTQPPKKAVEK-QQPVESSEDSSDESDSSSEEEKKPPTKAVVSKA 348
V P A P K P K EK + PV+ S +++ S +E+ K P K + K
Sbjct: 759 LDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKE 818
Query: 349 TTKPP-PAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPK 407
K P ++ + +E+++AP+ P K S K K APK
Sbjct: 819 EVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKE-------APK 871
Query: 408 QPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSR 467
V ++ K S E + EE + KK V T + +A AK + AK +
Sbjct: 872 PKVEEKKEPAVEKPKESKVE---AKKEEAEDKKKVPTPEKEAPAKVEVKEDAK-----PK 923
Query: 468 DSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSE 527
+ + + + + ++ SK A KK+ AAP K K+ KA+ ++
Sbjct: 924 EKTEVAKKEPDDAKAKEPSKPAEKKE-------AAPEK-KDTKEEKAKKPEEKPKTEAKA 975
Query: 528 EEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKK 572
+E++K K +P+A KA +S+ ++ K + + E++ K K
Sbjct: 976 KEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 101 bits (251), Expect = 3e-21
Identities = 119/474 (25%), Positives = 178/474 (37%), Gaps = 23/474 (4%)
Query: 181 KNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK 240
K++K + +T+ + K A + + EE K+ +
Sbjct: 449 KSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEE 508
Query: 241 KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNK-PGPYSSVPPPSAP- 298
P+K+ AK+PVK ++ S E + E K P K K P + PP A
Sbjct: 509 AASPEKE--AKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKS 566
Query: 299 PPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPP---PA 355
P K+ + K+ EK + E S S E+ K P + S A K P A
Sbjct: 567 PEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEA 626
Query: 356 KKAAE-SSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAP---KQPVG 411
K AE S + + S + E+ ++P K K + P KSP A +P K PV
Sbjct: 627 KSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE-KAKSPVKAEAKSPEKAKSPVK 685
Query: 412 GGQKLLTRKADSSSSEEESSSSEEEKTKKMVATT--KPKATAKAALSLPAKQAPQGSRDS 469
K KA S EE S + + K A + K K+ K P K ++
Sbjct: 686 AEAK-SPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEA 744
Query: 470 SSDSDSSSSEEEEEKTSKSAVKKKPQK-VAGGAAPSKPASAKKGKAESSNSSSSDDSSEE 528
S + S E+ + KS K P K A A P AK E S S +
Sbjct: 745 KSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK 804
Query: 529 EEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQ 588
E+ K K P+ + K+ Q K + ++ EEEK A + KK +
Sbjct: 805 EDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEE----KKDSK 860
Query: 589 NEAAKEAETPQAKKIKLQTPNT-FPKRKKGE--KRASSPFRRVREEEIEVDSRV 639
E A + E P+ K + + P PK K E K + ++V E E ++V
Sbjct: 861 KEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKV 914
Score = 92.8 bits (229), Expect = 1e-18
Identities = 85/309 (27%), Positives = 130/309 (42%), Gaps = 39/309 (12%)
Query: 59 KSAKVPER-----KLQANGPVAKKAKKKASSSD---SEDSSEEEEEVQGPPAK---KAAV 107
+ AK PE+ K +A P K+ +KA + D E + +EE + P K KA
Sbjct: 728 EEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKS 787
Query: 108 PAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSS 167
P K P KA + E + + E EE K PV++ KPQ K PPKKA+
Sbjct: 788 PVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEE--VKSPVKEEEKPQEVKVKEPPKKAEEE 845
Query: 168 DS-------DSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSS 220
+ + S ++E PK + PK P + + A KP + + +A
Sbjct: 846 KAPATPKTEEKKDSKKEEAPKKEAPK--PKVEEKKEPAVEKPKESKVEAKKEEAEDKKKV 903
Query: 221 SSSSSSSDDSEEEKAAATPK-KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQK 279
+ + E K A PK KT K+ A K + P K ++ + +EE+ K
Sbjct: 904 PTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAK 963
Query: 280 KPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKP 339
KP + KP + A K+L +P K EK +++S S+ +++ KP
Sbjct: 964 KP-EEKPKTEA-----KAKEDDKTLSKEPSKPKAEK----------AEKSSSTDQKDSKP 1007
Query: 340 PTKAVVSKA 348
P KA KA
Sbjct: 1008 PEKATEDKA 1016
Score = 91.7 bits (226), Expect = 2e-18
Identities = 106/468 (22%), Positives = 189/468 (40%), Gaps = 45/468 (9%)
Query: 240 KKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPP 299
K+TV ++ + V T + + E+ +EE +++ + S P A
Sbjct: 452 KETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAAS 511
Query: 300 PKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSE----EEKKPPTKAVVSKATTKPPPA 355
P+K P K+ E + P E+ +E+ S +E E+ K P K P
Sbjct: 512 PEKE-AKSPVKE--EAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPE 568
Query: 356 KKAAESSSD-----------SSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAA 404
K+ A+S ++ ++ S + ++P K K + PA KSP + A
Sbjct: 569 KEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPA-EAKSPVKEEAK 627
Query: 405 APKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQ 464
+P + V +K + + + S E++ S E+E+ K + K K+ KA P K
Sbjct: 628 SPAE-VKSPEKAKSPTKEEAKSPEKAKSPEKEEAK---SPEKAKSPVKAEAKSPEKAKSP 683
Query: 465 GSRDSSSDSDSSSSEEEEEKT---SKSAVKKKPQKVAGGAAPSKPASAKKGKAES---SN 518
++ S + S +EE K+ +KS VK++ + +P K + KA+S
Sbjct: 684 VKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEE 743
Query: 519 SSSSDDSSEEEEEKLKGKGSPRPQAP-KANGTSALTAQNGKAAKNSEEEEEEKKKAAVVV 577
+ S + + E+ K SP + P K S KA +EE + +KA +
Sbjct: 744 AKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPL 803
Query: 578 SKSGSL------KKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREE 631
+ KK + KE E PQ K+K PK+ + EK ++P + E
Sbjct: 804 KEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEP-----PKKAEEEKAPATP----KTE 854
Query: 632 EIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKR 679
E + + +A + + E A + K +K ++ + E KK+
Sbjct: 855 EKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKK 902
Score = 90.1 bits (222), Expect = 6e-18
Identities = 82/351 (23%), Positives = 156/351 (44%), Gaps = 22/351 (6%)
Query: 286 PGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSE-------DSSDESDSSSEEEKK 338
P P+S P P S+ T K+ EK + VE SE + ++E+ + E ++
Sbjct: 417 PIPFSL---PEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEE 473
Query: 339 PPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSP 398
+A + + ++ AE + + S +E+ +P K A + K KSP
Sbjct: 474 EEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSP 533
Query: 399 AVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLP 458
+ A +P + V +K + + + S E+ S E+E+ K P+ P
Sbjct: 534 EKEEAKSPAE-VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKS-----P 587
Query: 459 AKQAPQGSRDSSSDSDSSSSEEEEEKT---SKSAVKKKPQKVAGGAAPSKPASAKKGKAE 515
AK+ + ++ S + S +EE K+ +KS VK++ + A +P K S K +A+
Sbjct: 588 AKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAK 647
Query: 516 SSNSSSSDDSSEEEE-EKLKGKGSPRPQAP-KANGTSALTAQNGKAAKNS-EEEEEEKKK 572
S + S + E + EK K ++P KA A++ + AK+ +EE + +K
Sbjct: 648 SPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEK 707
Query: 573 AAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASS 623
A V + ++ ++ +EA+TP+ K ++ P++ K ++A +
Sbjct: 708 AKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKT 758
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 141 bits (355), Expect = 2e-33
Identities = 192/737 (26%), Positives = 279/737 (37%), Gaps = 124/737 (16%)
Query: 1 MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKS 60
MA+A RR +L PL+ L A + + +G A +LLDIY+ W ++
Sbjct: 1 MAEARKRR----ELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQT 56
Query: 61 AKVPERKLQANGPVAKKAKKKASSS--DSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGK 118
+++ RK +A A +AKK S + +SSEEEEE + AK A G
Sbjct: 57 SEL-GRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGA 115
Query: 119 AAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDE 178
+ + + E+ + P + K+P K A+ S + + S +E
Sbjct: 116 DLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175
Query: 179 PPKNQKPKITPVTVKAQTKAPPKPARAAP-KIANGKAASSSSSSSSSSSSDDSE------ 231
+ P A A P ++ G+A SSS +SSSS D E
Sbjct: 176 ----------------EGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEK 219
Query: 232 --EEKAAATPKKTVPKKQVVAKAPVKA--------ATTPTRKSSSSEDSSSDEEEE---Q 278
+ +AA+ P K P K P KA A P S SS + SSD EEE
Sbjct: 220 ILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAA 279
Query: 279 KKPMKNK-PGPYSSVPPPSAP---PPKKSLGTQPPKK---AVEKQQPVESSEDSSDESDS 331
K ++ K G S V SAP P+K PP K AV K Q + EDS S+
Sbjct: 280 KALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEE 339
Query: 332 SSEEEKKP-----------------PTKAVVSKATTKPPP------------AKKAAESS 362
S EE+ P P K K PP K+ +S
Sbjct: 340 SDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR 399
Query: 363 SDSSDSDSSED-----DEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLL 417
S S +SDS + + A KP G K+ KPA T + A P P G
Sbjct: 400 SSSEESDSDREALAAMNAAQVKPLG--KSPQVKPASTMGMGPLGKGAGPVPPGKVGPATP 457
Query: 418 TRKA-----DSSSSEEESSSSEEEKTKKMVATTKPKATAK----AALSLPAKQAPQGS-- 466
+ + DS SS EESS S + + VA + K+ S PAK PQ +
Sbjct: 458 SAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGP 517
Query: 467 ------------RDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKA 514
SS+ S S++ EE + +A + KP P A KK
Sbjct: 518 VAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL----KIPQTKACPKKTNT 573
Query: 515 ESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAA 574
+S + + K SP +P G + A++ +++ S + EEEK A
Sbjct: 574 TASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES-DSEEEKTGLA 632
Query: 575 VVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIE 634
V V ++ S+ K Q K A P + T P + + P + E +
Sbjct: 633 VTVGQAKSVGKGLQ---VKAASVPVKGSLGQGTAPVLPGK-------TGPTVTQVKAEKQ 682
Query: 635 VDSRVADNSFDAKRGAA 651
DS ++ D++ AA
Sbjct: 683 EDSESSEEESDSEEAAA 699
Score = 140 bits (353), Expect = 4e-33
Identities = 202/765 (26%), Positives = 282/765 (36%), Gaps = 193/765 (25%)
Query: 58 LKSAKVPERKLQANGPVAKKAKKKA----SSSDSEDSSEEEEEVQGPPAKK------AAV 107
L S E + A G AK A SSS+ SS +E +V+ ++K A+
Sbjct: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASA 228
Query: 108 PAK------RVGLPPGKAAAKASES----------SSSEESSDDDDEEDQKKQPVQKGVK 151
PAK PPGKA A AS++ SSSEESSD ++E K +Q
Sbjct: 229 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 288
Query: 152 ----------------PQAKAAKAPPKKA--------------KSSDSDSDSSSEDEPPK 181
P+ AA APP K S S +S SE+E P
Sbjct: 289 GKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 348
Query: 182 NQKPKITPVTVKAQT----KAPPKPARAAPKIANGKAASS----SSSSSSSSSSDDSEEE 233
KP V+A + ++P K A AP G AA+ S SSS++S+ +
Sbjct: 349 QAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSD 408
Query: 234 KAAATPKKTVPKKQVVAKAPVKAATT-------------PTRKSSSSEDSSSD---EEEE 277
+ A K + VK A+T P K + S+ EE+
Sbjct: 409 REALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDS 468
Query: 278 QKKPMKNKPGPYSSVPPPSAPPPKKSLGT------------QPPKKA------VEKQQPV 319
+ ++ VP AP +KSLG PP+KA V+ ++P+
Sbjct: 469 ESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPM 528
Query: 320 ESSEDSSDESDSSSEEE--------------KKPPTKAVVSKATT----KPPPAK----- 356
++SE S + SDS+ EE K P TKA K T K P +
Sbjct: 529 DNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQA 588
Query: 357 ----------------------KAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVT 394
+ AE SS S +SDS E+ + G K+ V
Sbjct: 589 PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVK 648
Query: 395 TKSPAVKPA----AAPKQPVGGGQKLLTRKA----DSSSSEEESSSSEEEKTKKMVATTK 446
S VK + AP P G + KA DS SSEEES S E + V T+
Sbjct: 649 AASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSV 708
Query: 447 PKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVK---KKPQK------- 496
K AKA + A +AP S+ ++ + ++ S S VK + PQ
Sbjct: 709 KKTQAKA--NPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARG 766
Query: 497 ----VAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKL-----------------KG 535
+ G A + A A+ G E S SS + SEEE E L
Sbjct: 767 PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 826
Query: 536 KGSPR----PQAPKANGTSALTAQNGK---AAKNSEEEEEEKKKAAVVVSKSGSLKKRKQ 588
K SPR P P G SA AQ GK + +SEE + + + A V S
Sbjct: 827 KESPRKGAAPTPPGKTGPSA--AQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIF 884
Query: 589 NEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEI 633
+ + P A + Q +T K + E A S +E++
Sbjct: 885 VDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDV 929
Score = 125 bits (313), Expect = 2e-28
Identities = 159/624 (25%), Positives = 252/624 (40%), Gaps = 89/624 (14%)
Query: 79 KKKASSSDSEDSSEEEEEV--QGPPAKK------AAVPAKR------VGLPPGKA----- 119
++ + SS+ E SEEE E Q P+ K A PAK PPGK
Sbjct: 788 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 847
Query: 120 -AAKASESSSSEESSDDDDEE-----------------DQKKQPVQKGVKPQAKAAKAPP 161
A K +S SS E SD D E D + P P A + P
Sbjct: 848 QAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP 907
Query: 162 KKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSS 221
+KA++S+S + SSS + ++ P +T +T P A P+IA + + +SSS
Sbjct: 908 RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPT-AHPRIAPKASMAGASSS 966
Query: 222 SSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKP 281
SS D ++++ AT V KK A P+ A +SE +
Sbjct: 967 KESSRISDGKKQEGPATQ---VSKKNP-ASLPLTQAALKVLAQKASEAQPPVARTQPSSG 1022
Query: 282 MKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPV---ESSEDSSDESDSSS--EEE 336
+ + G + P S K K E QQ ESS+DS D SDSSS EE+
Sbjct: 1023 VDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEED 1082
Query: 337 KKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDE-APSKPA-------GTTKNSS 388
+ P A + P P++ E+ + + ++SSEDD APS+ G T +S
Sbjct: 1083 GEGPQGAKSAHTLVGPTPSR--TETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANS 1140
Query: 389 NKPAVTTK---SPAVKPAAAPKQPVGGGQKLLTRKA-----DSSSSEEESSSSEEEKTKK 440
T K SP+V A K G Q+ ++A + +E +S + +K++K
Sbjct: 1141 QASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRK 1200
Query: 441 MVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSS---------EEEEEK---TSKS 488
+ AL Q G +++ +S E+E +K T+K
Sbjct: 1201 PKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKE 1260
Query: 489 AVKK----KPQKVAGGAAPSK-PASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQA 543
+ +K + +K++G ++ P S KK K + + S E+ KGK +
Sbjct: 1261 SSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKAS 1320
Query: 544 PKANGTSALTAQNGKAAKNSEEEEEEKKKAAVV---VSKSGSLKKRKQNEAAKEAETPQA 600
+ + AK+ EEE +K V S S K++K+++ K+ + +
Sbjct: 1321 GDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKE 1380
Query: 601 KKIKLQTPNT----FPKRKKGEKR 620
KK K + +T P +KK +K+
Sbjct: 1381 KKKKAKKASTKDSESPSQKKKKKK 1404
Score = 104 bits (259), Expect = 3e-22
Identities = 169/699 (24%), Positives = 262/699 (37%), Gaps = 169/699 (24%)
Query: 60 SAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPP--G 117
+A+ P K + P K A+ + S+ + V+ P + + V A+ P G
Sbjct: 719 AARAPSAKGTISAP--GKVVTAAAQAKQRSPSKVKPPVRNP--QNSTVLARGPASVPSVG 774
Query: 118 KAAAKASE--------SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAK---- 165
KA A A++ S SSEE SD ++E + Q G Q +AA AP K++
Sbjct: 775 KAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGA 834
Query: 166 ---------------SSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPP--------KP 202
DS SSSE+ + P AQ PP P
Sbjct: 835 APTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPA---AVTSAQVIKPPLIFVDPNRSP 891
Query: 203 ARAAPKIANGKAASS------SSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPV-- 254
A A A +AAS+ S S++ SSSS+ +E+ AT T + V P
Sbjct: 892 AGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAH 951
Query: 255 -----KAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYS-----------------SV 292
KA+ S S S +++E +K P S +
Sbjct: 952 PRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQ 1011
Query: 293 PPPSAPPPK----KSLGTQP------------------PKKAVEKQQPV---ESSEDSSD 327
PP + P ++GT P K E QQ ESS+DS D
Sbjct: 1012 PPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSED 1071
Query: 328 ESDSS--SEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDD-EAPSK----- 379
SDSS SEE+ + P A + P P++ E+ + + ++SSEDD APS+
Sbjct: 1072 SSDSSSGSEEDGEGPQGAKSAHTLVGPTPSR--TETLVEETAAESSEDDVVAPSQSLLSG 1129
Query: 380 --PAGTTKNSSNKPAVTTK---SPAVKPAAAPKQPVGGGQKLLTRKA------DSSSSEE 428
G T +S T K SP+V A K G Q+ ++A + E
Sbjct: 1130 YMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEA 1189
Query: 429 ESSSSEEEKTKKMVATTKPKATAKA---------------------------ALSLPAKQ 461
S ++ ++ K P+A+ A L+ +Q
Sbjct: 1190 ASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQ 1249
Query: 462 APQGSRDSSSDSDSSSSEEEEEKTS------KSAVKKKPQKVAGGAAPSKPASAKKGKAE 515
+ D++ +S E + K S ++ KK +K+ G S +K
Sbjct: 1250 ERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTT 1309
Query: 516 SSNSSSSDDSSEEEEEKLKGKGS---------PRPQAPKANGTSALTAQNGKAAKNSEEE 566
S + D +S + +EK KGKGS P + K GT Q+ +K +++
Sbjct: 1310 SKGKAKRDKASGDVKEK-KGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKK 1368
Query: 567 EEEKKKAAVVVSKSGSLKKRKQNEAA-KEAETPQAKKIK 604
+++KK K KK+K +A+ K++E+P KK K
Sbjct: 1369 SDKRKK-----DKEKKEKKKKAKKASTKDSESPSQKKKK 1402
Score = 54.3 bits (129), Expect = 4e-07
Identities = 82/377 (21%), Positives = 143/377 (37%), Gaps = 81/377 (21%)
Query: 58 LKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEE----EEEVQGPPAKKAAVPAKRVG 113
L+ K+PE V + K SS DSEDSS+ EE+ +GP K+A VG
Sbjct: 1048 LRKPKLPE--------VQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL--VG 1097
Query: 114 LPPGKAAAKASESSSSEESSDDD---DEEDQKKQPVQKGVKP-QAKAAKAPPKKAKSSDS 169
P + E+++ ESS+DD + + G+ P ++A+KA PK S
Sbjct: 1098 PTPSRTETLVEETAA--ESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSV 1155
Query: 170 DSDSSSEDEPPKNQKPK-------ITPVT--VKAQTKAPPKPARAAPKIANGKAASS--- 217
S +++D+P Q+ K ++P T +A + P+ +R K A AS+
Sbjct: 1156 SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLAL 1215
Query: 218 ----------------------------------------SSSSSSSSSSDDSEEEK--- 234
++ SS +S + K
Sbjct: 1216 QSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSG 1275
Query: 235 ---AAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSS 291
AA TP+ KK++ A +A+ +P + S++S+ + ++ K G S
Sbjct: 1276 DQPAARTPRSK-KKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGS 1334
Query: 292 VPPPSAPPPK--KSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKAT 349
P + K +GT + E + + D +E+KK KA +
Sbjct: 1335 QGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSE 1394
Query: 350 TKPPPAKKAAESSSDSS 366
+ KK + +++ +
Sbjct: 1395 SPSQKKKKKKKKTAEQT 1411
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 141 bits (355), Expect = 2e-33
Identities = 192/737 (26%), Positives = 279/737 (37%), Gaps = 124/737 (16%)
Query: 1 MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKS 60
MA+A RR +L PL+ L A + + +G A +LLDIY+ W ++
Sbjct: 1 MAEARKRR----ELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQT 56
Query: 61 AKVPERKLQANGPVAKKAKKKASSS--DSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGK 118
+++ RK +A A +AKK S + +SSEEEEE + AK A G
Sbjct: 57 SEL-GRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGA 115
Query: 119 AAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDE 178
+ + + E+ + P + K+P K A+ S + + S +E
Sbjct: 116 DLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175
Query: 179 PPKNQKPKITPVTVKAQTKAPPKPARAAP-KIANGKAASSSSSSSSSSSSDDSE------ 231
+ P A A P ++ G+A SSS +SSSS D E
Sbjct: 176 ----------------EGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEK 219
Query: 232 --EEKAAATPKKTVPKKQVVAKAPVKA--------ATTPTRKSSSSEDSSSDEEEE---Q 278
+ +AA+ P K P K P KA A P S SS + SSD EEE
Sbjct: 220 ILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAA 279
Query: 279 KKPMKNK-PGPYSSVPPPSAP---PPKKSLGTQPPKK---AVEKQQPVESSEDSSDESDS 331
K ++ K G S V SAP P+K PP K AV K Q + EDS S+
Sbjct: 280 KALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEE 339
Query: 332 SSEEEKKP-----------------PTKAVVSKATTKPPP------------AKKAAESS 362
S EE+ P P K K PP K+ +S
Sbjct: 340 SDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR 399
Query: 363 SDSSDSDSSED-----DEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLL 417
S S +SDS + + A KP G K+ KPA T + A P P G
Sbjct: 400 SSSEESDSDREALAAMNAAQVKPLG--KSPQVKPASTMGMGPLGKGAGPVPPGKVGPATP 457
Query: 418 TRKA-----DSSSSEEESSSSEEEKTKKMVATTKPKATAK----AALSLPAKQAPQGS-- 466
+ + DS SS EESS S + + VA + K+ S PAK PQ +
Sbjct: 458 SAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGP 517
Query: 467 ------------RDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKA 514
SS+ S S++ EE + +A + KP P A KK
Sbjct: 518 VAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL----KIPQTKACPKKTNT 573
Query: 515 ESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAA 574
+S + + K SP +P G + A++ +++ S + EEEK A
Sbjct: 574 TASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES-DSEEEKTGLA 632
Query: 575 VVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIE 634
V V ++ S+ K Q K A P + T P + + P + E +
Sbjct: 633 VTVGQAKSVGKGLQ---VKAASVPVKGSLGQGTAPVLPGK-------TGPTVTQVKAEKQ 682
Query: 635 VDSRVADNSFDAKRGAA 651
DS ++ D++ AA
Sbjct: 683 EDSESSEEESDSEEAAA 699
Score = 140 bits (353), Expect = 4e-33
Identities = 202/765 (26%), Positives = 282/765 (36%), Gaps = 193/765 (25%)
Query: 58 LKSAKVPERKLQANGPVAKKAKKKA----SSSDSEDSSEEEEEVQGPPAKK------AAV 107
L S E + A G AK A SSS+ SS +E +V+ ++K A+
Sbjct: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASA 228
Query: 108 PAK------RVGLPPGKAAAKASES----------SSSEESSDDDDEEDQKKQPVQKGVK 151
PAK PPGKA A AS++ SSSEESSD ++E K +Q
Sbjct: 229 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 288
Query: 152 ----------------PQAKAAKAPPKKA--------------KSSDSDSDSSSEDEPPK 181
P+ AA APP K S S +S SE+E P
Sbjct: 289 GKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 348
Query: 182 NQKPKITPVTVKAQT----KAPPKPARAAPKIANGKAASS----SSSSSSSSSSDDSEEE 233
KP V+A + ++P K A AP G AA+ S SSS++S+ +
Sbjct: 349 QAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSD 408
Query: 234 KAAATPKKTVPKKQVVAKAPVKAATT-------------PTRKSSSSEDSSSD---EEEE 277
+ A K + VK A+T P K + S+ EE+
Sbjct: 409 REALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDS 468
Query: 278 QKKPMKNKPGPYSSVPPPSAPPPKKSLGT------------QPPKKA------VEKQQPV 319
+ ++ VP AP +KSLG PP+KA V+ ++P+
Sbjct: 469 ESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPM 528
Query: 320 ESSEDSSDESDSSSEEE--------------KKPPTKAVVSKATT----KPPPAK----- 356
++SE S + SDS+ EE K P TKA K T K P +
Sbjct: 529 DNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQA 588
Query: 357 ----------------------KAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVT 394
+ AE SS S +SDS E+ + G K+ V
Sbjct: 589 PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVK 648
Query: 395 TKSPAVKPA----AAPKQPVGGGQKLLTRKA----DSSSSEEESSSSEEEKTKKMVATTK 446
S VK + AP P G + KA DS SSEEES S E + V T+
Sbjct: 649 AASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSV 708
Query: 447 PKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVK---KKPQK------- 496
K AKA + A +AP S+ ++ + ++ S S VK + PQ
Sbjct: 709 KKTQAKA--NPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARG 766
Query: 497 ----VAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKL-----------------KG 535
+ G A + A A+ G E S SS + SEEE E L
Sbjct: 767 PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 826
Query: 536 KGSPR----PQAPKANGTSALTAQNGK---AAKNSEEEEEEKKKAAVVVSKSGSLKKRKQ 588
K SPR P P G SA AQ GK + +SEE + + + A V S
Sbjct: 827 KESPRKGAAPTPPGKTGPSA--AQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIF 884
Query: 589 NEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEI 633
+ + P A + Q +T K + E A S +E++
Sbjct: 885 VDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDV 929
Score = 123 bits (309), Expect = 5e-28
Identities = 161/624 (25%), Positives = 253/624 (40%), Gaps = 90/624 (14%)
Query: 79 KKKASSSDSEDSSEEEEEV--QGPPAKK------AAVPAKR------VGLPPGKA----- 119
++ + SS+ E SEEE E Q P+ K A PAK PPGK
Sbjct: 788 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 847
Query: 120 -AAKASESSSSEESSDDDDEE-----------------DQKKQPVQKGVKPQAKAAKAPP 161
A K +S SS E SD D E D + P P A + P
Sbjct: 848 QAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP 907
Query: 162 KKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSS 221
+KA++S+S + SSS + ++ P +T +T P A P+IA + + +SSS
Sbjct: 908 RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPT-AHPRIAPKASMAGASSS 966
Query: 222 SSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKP 281
SS D ++++ AT V KK A P+ A +SE +
Sbjct: 967 KESSRISDGKKQEGPATQ---VSKKNP-ASLPLTQAALKVLAQKASEAQPPVARTQPSSG 1022
Query: 282 MKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPV---ESSEDSSDESDSSS--EEE 336
+ + G + P S K K E QQ ESS+DS D SDSSS EE+
Sbjct: 1023 VDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEED 1082
Query: 337 KKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDE-APSKPA-------GTTKNSS 388
+ P A S T P P++ E+ + + ++SSEDD APS+ G T +S
Sbjct: 1083 GEGPQGAK-SAHTLGPTPSR--TETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANS 1139
Query: 389 NKPAVTTK---SPAVKPAAAPKQPVGGGQKLLTRKA-----DSSSSEEESSSSEEEKTKK 440
T K SP+V A K G Q+ ++A + +E +S + +K++K
Sbjct: 1140 QASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRK 1199
Query: 441 MVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSS---------EEEEEK---TSKS 488
+ AL Q G +++ +S E+E +K T+K
Sbjct: 1200 PKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKE 1259
Query: 489 AVKK----KPQKVAGGAAPSK-PASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQA 543
+ +K + +K++G ++ P S KK K + + S E+ KGK +
Sbjct: 1260 SSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKAS 1319
Query: 544 PKANGTSALTAQNGKAAKNSEEEEEEKKKAAVV---VSKSGSLKKRKQNEAAKEAETPQA 600
+ + AK+ EEE +K V S S K++K+++ K+ + +
Sbjct: 1320 GDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKE 1379
Query: 601 KKIKLQTPNT----FPKRKKGEKR 620
KK K + +T P +KK +K+
Sbjct: 1380 KKKKAKKASTKDSESPSQKKKKKK 1403
Score = 105 bits (261), Expect = 2e-22
Identities = 174/711 (24%), Positives = 271/711 (38%), Gaps = 142/711 (19%)
Query: 60 SAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPP--G 117
+A+ P K + P K A+ + S+ + V+ P + + V A+ P G
Sbjct: 719 AARAPSAKGTISAP--GKVVTAAAQAKQRSPSKVKPPVRNP--QNSTVLARGPASVPSVG 774
Query: 118 KAAAKASE--------SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAK---- 165
KA A A++ S SSEE SD ++E + Q G Q +AA AP K++
Sbjct: 775 KAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGA 834
Query: 166 ---------------SSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPP--------KP 202
DS SSSE+ + P AQ PP P
Sbjct: 835 APTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPA---AVTSAQVIKPPLIFVDPNRSP 891
Query: 203 ARAAPKIANGKAASS------SSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKA 256
A A A +AAS+ S S++ SSSS+ +E+ AT T + V P
Sbjct: 892 AGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMP--T 949
Query: 257 ATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVP---PPSAPPPKKSLGTQPPKKAV 313
A +S +SS +E + K + GP + V P S P + +L +KA
Sbjct: 950 AHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVL-AQKAS 1008
Query: 314 EKQQPVESSEDSSD-ESDSSSEEEKKPPTKAVVSKATTK--------PPPAKKAAESSSD 364
E Q PV ++ SS +S + P + +V +K T K A KA ESS D
Sbjct: 1009 EAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDD 1068
Query: 365 SSDS--DSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQP---VGGGQKLLTR 419
S DS SS +E P G + P + V+ AA V Q LL+
Sbjct: 1069 SEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSG 1128
Query: 420 KADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSE 479
+ S +S+ AT K ++ + +L AK P G +++
Sbjct: 1129 YMTPGLTPANSQASK--------ATPKLDSSPSVSSTLAAKDDPDGKQEA---------- 1170
Query: 480 EEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSP 539
KPQ+ AG +P K G E+++ ++ S + + KG G+P
Sbjct: 1171 -------------KPQQAAGMLSP------KTGGKEAASGTTPQKSRKPK----KGAGNP 1207
Query: 540 RPQ--APKANGTSALTAQ---------NGKAAKNSEEEEEEKKKAAVVVSKSGSLK---- 584
+ A ++N T L Q K E E+++K V +K S K
Sbjct: 1208 QASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWES 1267
Query: 585 -KRKQNEAAKEAETPQAKK-------------IKLQTPNTFPKRKKGEKRASSPFRRVRE 630
KRK + A TP++KK + + +T K K +AS + +
Sbjct: 1268 RKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKG 1327
Query: 631 EEIEVDSRVADNSFDAKRGAAG--DWGERANQVLKFTKGKSFRHEKTKKKR 679
+ D + + G + G+++N K K KS + +K K+K+
Sbjct: 1328 KGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKK 1378
Score = 53.9 bits (128), Expect = 5e-07
Identities = 81/377 (21%), Positives = 143/377 (37%), Gaps = 82/377 (21%)
Query: 58 LKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEE----EEEVQGPPAKKAAVPAKRVG 113
L+ K+PE V + K SS DSEDSS+ EE+ +GP K+A +G
Sbjct: 1048 LRKPKLPE--------VQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSA---HTLG 1096
Query: 114 LPPGKAAAKASESSSSEESSDDD---DEEDQKKQPVQKGVKP-QAKAAKAPPKKAKSSDS 169
P + E+++ ESS+DD + + G+ P ++A+KA PK S
Sbjct: 1097 PTPSRTETLVEETAA--ESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSV 1154
Query: 170 DSDSSSEDEPPKNQKPK-------ITPVT--VKAQTKAPPKPARAAPKIANGKAASS--- 217
S +++D+P Q+ K ++P T +A + P+ +R K A AS+
Sbjct: 1155 SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLAL 1214
Query: 218 ----------------------------------------SSSSSSSSSSDDSEEEK--- 234
++ SS +S + K
Sbjct: 1215 QSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSG 1274
Query: 235 ---AAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSS 291
AA TP+ KK++ A +A+ +P + S++S+ + ++ K G S
Sbjct: 1275 DQPAARTPRSK-KKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGS 1333
Query: 292 VPPPSAPPPK--KSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKAT 349
P + K +GT + E + + D +E+KK KA +
Sbjct: 1334 QGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSE 1393
Query: 350 TKPPPAKKAAESSSDSS 366
+ KK + +++ +
Sbjct: 1394 SPSQKKKKKKKKTAEQT 1410
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 112 bits (280), Expect = 1e-24
Identities = 98/481 (20%), Positives = 190/481 (39%), Gaps = 21/481 (4%)
Query: 70 ANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSS 129
+N + + + SS+S DSS+ + G + + ++ +S+SS S
Sbjct: 821 SNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSS-------NRSDSSNSSDSSDSSDS 873
Query: 130 EESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITP 189
SSD D D + + ++ + SSDS + S S D + + +
Sbjct: 874 SNSSDSSDSSDSNESSNSSDSSDSSNSSDSD-----SSDSSNSSDSSDSSNSSDSSESSN 928
Query: 190 VTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVV 249
+ + + + ++ + ++ SS+SS SS+SSD S+ + ++
Sbjct: 929 SSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDS 988
Query: 250 AKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPP 309
+ + + ++ + SS S DSS + N +S + S +
Sbjct: 989 SDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDS 1048
Query: 310 KKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSD 369
+ + +S DSSD SDSS + + + S ++ + +++SS S SD
Sbjct: 1049 SDSSDSS----NSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSD 1104
Query: 370 SSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEE 429
SS D + S + + +SSN + S + + + + +DSS S +
Sbjct: 1105 SS--DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDS 1162
Query: 430 SSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSA 489
S SS+ + ++ ++ ++ S + + S DSS SDSS S + + + S
Sbjct: 1163 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSS-DSSDSSDSSDSSDSSDSSDSS- 1220
Query: 490 VKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGT 549
+ + S +S ++SSNSS S DSS+ + Q+ NG
Sbjct: 1221 -DSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGN 1279
Query: 550 S 550
+
Sbjct: 1280 N 1280
Score = 111 bits (277), Expect = 3e-24
Identities = 112/593 (18%), Positives = 231/593 (38%), Gaps = 29/593 (4%)
Query: 24 DNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKAS 83
D+ S ++ + ++ + D+N+SS D + + +N + + +
Sbjct: 553 DSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSD 612
Query: 84 SSDSEDSSEE-------EEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDD 136
SSDS DSS+ E + +K + + ++ +S SS+S +SSD
Sbjct: 613 SSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSS 672
Query: 137 DEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDS----DSDSS-SEDEPPKNQKPKITPVT 191
D D + ++ + ++SSDS DSDSS S D N + +
Sbjct: 673 DSSDSSSSSDSSNSSDSSDSSDSS-NSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNS 731
Query: 192 VKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAK 251
+ + + + +N +S SS SS+SS S DS + ++ +
Sbjct: 732 SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSND---- 787
Query: 252 APVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKK 311
+ ++ + SS+S DSS+ + + SS S+ S +
Sbjct: 788 ---SSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDS 844
Query: 312 AVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSS 371
+ S + SD S+SS + + + S ++ + +++SS S+ SDS
Sbjct: 845 SDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSD 904
Query: 372 EDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESS 431
D + S + + NSS+ + S + + + +DSS+S + S+
Sbjct: 905 SSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSN 964
Query: 432 SSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSS-------SSEEEEEK 484
SS+ + ++ ++ + S + + S DSS+ SDSS SS +
Sbjct: 965 SSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSD--SSDSSNSSDSSDSSDSSDSSNSSDSS 1022
Query: 485 TSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAP 544
S + + ++ S +S ++SSNSS S DSS+ + S +
Sbjct: 1023 NSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1082
Query: 545 KANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAET 597
+++ +S + + + + + + ++ S S ++++ +++
Sbjct: 1083 ESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1135
Score = 111 bits (277), Expect = 3e-24
Identities = 99/525 (18%), Positives = 205/525 (39%), Gaps = 5/525 (0%)
Query: 78 AKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDD 137
+ + SSDS DSS+ + + + + ++ +S+SS S +SS+ D
Sbjct: 695 SSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSD 754
Query: 138 EEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTK 197
D + ++ + S +DS +SS+ N +
Sbjct: 755 SSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSD 814
Query: 198 APPKPARAAPKIANGKAASSSSSSSSSS-SSDDSEEEKAAATPKKTVPKKQVVAKAPVKA 256
+ + + +N +S SS+SS SS SSD S+ + ++ + + + +
Sbjct: 815 SSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSS 874
Query: 257 ATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQ 316
++ + SS S +SS+ + + SS S+ S ++ +
Sbjct: 875 NSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSN 934
Query: 317 QPVES-SEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAES-SSDSSDSDSSED- 373
S S DSSD SDSS+ + + + S ++ + + S SSDSSDS S D
Sbjct: 935 SSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDS 994
Query: 374 -DEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSS 432
D + S + + +SS+ + S + + + + +DSS S + S S
Sbjct: 995 SDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDS 1054
Query: 433 SEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKK 492
S + ++ ++ ++ S + ++ S S+S S SS+ + S +
Sbjct: 1055 SNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1114
Query: 493 KPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSAL 552
+ ++ S +S ++SSNSS S DSSE + S + ++ +S
Sbjct: 1115 SDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDS 1174
Query: 553 TAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAET 597
+ + + + + + ++ S S ++++ +++
Sbjct: 1175 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1219
Score = 108 bits (271), Expect = 1e-23
Identities = 98/551 (17%), Positives = 212/551 (38%), Gaps = 19/551 (3%)
Query: 75 AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSD 134
+ + + SSDS +SS+ + + ++ + ++ +S SS S SSD
Sbjct: 749 SSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSD 808
Query: 135 DDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKA 194
D D + + + S SDSS + + + + + +
Sbjct: 809 SSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSS 868
Query: 195 QTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPV 254
+ + ++ + ++++SS SS SS+SSD + + ++ +++
Sbjct: 869 DSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSN 928
Query: 255 KAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVE 314
+ + + SS+S DSS + N +S + S + +
Sbjct: 929 SSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSS-- 986
Query: 315 KQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSED- 373
S DSSD SDSS + + S ++ + +++SS+ S SDSS+
Sbjct: 987 ------DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSS 1040
Query: 374 DEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSS 433
D + S + + +SSN + S + + + + +DSS+S + S SS
Sbjct: 1041 DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSS 1100
Query: 434 EEEKTKKMVATTKPKATAKAALSLPAKQAPQGS--RDSSSDSDSSSSEEEEEKTSKSAVK 491
+ + ++ ++ ++ S + + S DSS+ SDSS S E + + S
Sbjct: 1101 DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSD-- 1158
Query: 492 KKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSA 551
+ ++ S +S ++SSNSS S DSS+ + S + ++ +S
Sbjct: 1159 ------SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1212
Query: 552 LTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTF 611
+ + + + + + +++ S S ++++ +++ + ++
Sbjct: 1213 SSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQ 1272
Query: 612 PKRKKGEKRAS 622
K G S
Sbjct: 1273 SKSGNGNNNGS 1283
Score = 107 bits (268), Expect = 3e-23
Identities = 118/617 (19%), Positives = 229/617 (37%), Gaps = 46/617 (7%)
Query: 44 DANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKK--KASSSDSEDSSEEEEEVQGPP 101
DAN+ S + S S E K NG +K A+ S+SD+ +S G
Sbjct: 476 DANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGND 535
Query: 102 AKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDD--------DEEDQKKQPVQKGVKPQ 153
+ K ++ +S SS S +SSD D D +
Sbjct: 536 DNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDS 595
Query: 154 AKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGK 213
+ ++ + S SDS SS+ K+ K + + +K+ + ++ N
Sbjct: 596 SDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSD 655
Query: 214 AASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSD 273
++ SS+SS+SS SSD S+ ++++ + + ++ + S SS+ S SD
Sbjct: 656 SSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDS----SDSSDSSNSSESSDSSDSSDSD 711
Query: 274 EEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVES----SEDSSDES 329
+ N SS S+ S + + S S DSSD S
Sbjct: 712 SSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 771
Query: 330 DSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSN 389
DSS + + + S ++ + +++SS+ S SDSS+ ++ S + + NSS+
Sbjct: 772 DSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSD 831
Query: 390 KPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKA 449
+ S + + + G + ++DSS+S + S SS+ + ++
Sbjct: 832 SSDSSNSSDSSDSSDSSD----GSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNE 887
Query: 450 TAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASA 509
++ ++ S DSS+ SDS SS+ S + S + +
Sbjct: 888 SSNSS----------DSSDSSNSSDSDSSDSSNSSDSSDS--------------SNSSDS 923
Query: 510 KKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEE 569
+ S NS+SSD S+ + + + ++ +++ + + ++ +S+
Sbjct: 924 SESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSS 983
Query: 570 KKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVR 629
+ S S + + ++ + N+ + SS
Sbjct: 984 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSS 1043
Query: 630 EEEIEVDSRVADNSFDA 646
+ DS + NS D+
Sbjct: 1044 DSSDSSDSSDSSNSSDS 1060
Score = 106 bits (264), Expect = 8e-23
Identities = 94/526 (17%), Positives = 206/526 (39%), Gaps = 19/526 (3%)
Query: 78 AKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDD- 136
+ ++SSDS DSS+ + + ++ + ++ +SESS S +SSD D
Sbjct: 659 SSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSD------SSDSSNSSESSDSSDSSDSDS 712
Query: 137 -DEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQ 195
D D + + + SSDS S+S D + + + +
Sbjct: 713 SDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 772
Query: 196 TKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVK 255
+ + ++ + ++ SS SS+SS SS+ S+ ++ + + +
Sbjct: 773 SSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDS 832
Query: 256 AATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEK 315
+ ++ + SS S DSS + + + SS S+ S + + +
Sbjct: 833 SDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSS 892
Query: 316 QQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDE 375
S+ SD SDSS+ + + + S ++ +++SS+ S SDSS+
Sbjct: 893 DSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSN 952
Query: 376 APSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEE 435
+ + ++S+ + + S + + + + +DSS+S + S SS+
Sbjct: 953 SSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1012
Query: 436 EKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKS----AVK 491
+ ++ ++ ++ S S DSS SDSS S + + ++ S +
Sbjct: 1013 SDSSNSSDSSNSSDSSNSSDS-------SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1065
Query: 492 KKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSA 551
+ ++ S +S ++SSNSS S DSS+ + S + ++ +S
Sbjct: 1066 SSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD 1125
Query: 552 LTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAET 597
+ + + + + ++ S S ++++ +++
Sbjct: 1126 SSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDS 1171
Score = 106 bits (264), Expect = 8e-23
Identities = 96/460 (20%), Positives = 184/460 (40%), Gaps = 17/460 (3%)
Query: 66 RKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASE 125
R +N + + ++SSDS DSS+ E + ++ + ++ +S+
Sbjct: 858 RSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSS-DSSD 916
Query: 126 SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKP 185
SS+S +SS+ + D + ++ + S+ SDS +SS+ +
Sbjct: 917 SSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDS 976
Query: 186 KITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPK 245
+ + + + + + +N +S SS SS SS+S DS ++ +
Sbjct: 977 SDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDS 1036
Query: 246 KQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLG 305
+ ++ + S+SS+ S S + + + SS S+ S
Sbjct: 1037 SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDS 1096
Query: 306 TQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDS 365
+ + S DSSD SDSS+ + + + S ++ + ++ESS S
Sbjct: 1097 SDSSDSSDSSDS--SDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSS 1154
Query: 366 SDSDSSED-DEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSS 424
SDSS+ D + S + + +SSN + S + + + + +DSS
Sbjct: 1155 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS------------SDSSDSS 1202
Query: 425 SSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEK 484
S + S SS+ + ++ ++ + S + + S DSS+ SDSS S + +
Sbjct: 1203 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSS-DSSNSSDSSDSSDSSDS 1261
Query: 485 TSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDD 524
TS S + Q +G + S + SN S+SDD
Sbjct: 1262 TSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSDD 1301
Score = 103 bits (257), Expect = 5e-22
Identities = 126/638 (19%), Positives = 227/638 (35%), Gaps = 67/638 (10%)
Query: 26 QLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKV--PERKLQANGPVAKKAKKKAS 83
Q SE NK + T D+N+ D Y F KS + P ++NG ++ +
Sbjct: 428 QKSEPGNKVGHSN--TGSDSNSDGY-DSYDFDDKSMQGDDPNSSDESNGNDDANSESDNN 484
Query: 84 SSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKK 143
SS D+S +E K S+S +E+ D +
Sbjct: 485 SSSRGDASYNSDE--------------------SKDNGNGSDSKGAEDDDSDSTSDTNNS 524
Query: 144 QPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPA 203
G K+ K KS SDSDSS N + +
Sbjct: 525 DSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSS----NSSDSSDSSDSDSSDSNSSSDS 580
Query: 204 RAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRK 263
++ ++ + S SS SS+SS S DS + ++ + K +K+ ++ + ++
Sbjct: 581 DSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKS 640
Query: 264 SSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSE 323
SS +SS + N S + S + +S
Sbjct: 641 DSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSS-------------NSS 687
Query: 324 DSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGT 383
DSSD SDSS+ E + + S ++ SSDSS+S+SS+ D + S +
Sbjct: 688 DSSDSSDSSNSSESSDSSDSSDSDSS-----------DSSDSSNSNSSDSDSSNSSDSSD 736
Query: 384 TKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVA 443
+ NSS+ + S + + + + +DSS S + S SS+ +
Sbjct: 737 SSNSSDSSDSSDSSNSSDSSDSSDS---------SNSSDSSDSSDSSDSSDSSNSSDSND 787
Query: 444 TTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAP 503
++ ++ ++ S + + S DSS SDS SS + S + + ++
Sbjct: 788 SSNSSDSSDSSNSSDSSNSSDSS-DSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSD 846
Query: 504 SKPA--SAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAK 561
S S +++SSNSS S DSS+ S ++ +N + + + N +
Sbjct: 847 SSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNES--SNSSDSSDSSNSSDSD 904
Query: 562 NSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRA 621
+S+ + S S N + ++ + N+ +
Sbjct: 905 SSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSN 964
Query: 622 SSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERAN 659
SS + S +D+S + + D + +N
Sbjct: 965 SSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSN 1002
Score = 79.0 bits (193), Expect = 1e-14
Identities = 78/422 (18%), Positives = 166/422 (39%), Gaps = 14/422 (3%)
Query: 24 DNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKAS 83
D+ S ++ + ++ ++ D++ SS S S+ E ++ + + +
Sbjct: 884 DSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSD 943
Query: 84 SSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKK 143
SSDS DSS + + ++ + ++ +S+SS S +SSD D D
Sbjct: 944 SSDSSDSSNSSDSSNSSDSSNSS-DSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSN 1002
Query: 144 QPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPA 203
+ ++ + + SSDS + S S D + + + + + +
Sbjct: 1003 SSDSSDSSDSSDSSNSSDS-SNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSS 1061
Query: 204 RAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRK 263
++ + ++ SS SS SS SSD S+ ++ + + + + + ++ +
Sbjct: 1062 DSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDS--SDSSDSSDSSDSSD 1119
Query: 264 SSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSE 323
SS+S DSS + N S + S + + + +SS
Sbjct: 1120 SSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSN 1179
Query: 324 --------DSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAES--SSDSSDSDSSED 373
DSSD SDSS + + + S ++ + +++S SSDS++S S D
Sbjct: 1180 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSD 1239
Query: 374 DEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSS 433
S + ++ +S + + + S + + + + G +DS S+ S+S
Sbjct: 1240 SSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTS 1299
Query: 434 EE 435
++
Sbjct: 1300 DD 1301
Score = 68.2 bits (165), Expect = 3e-11
Identities = 93/518 (17%), Positives = 187/518 (36%), Gaps = 43/518 (8%)
Query: 117 GKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSE 176
G + ++ E S DD+DEE + K Q SS + S E
Sbjct: 244 GSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKE 303
Query: 177 DEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAA 236
P+ ++ V +K+ A P+ NG + + S E
Sbjct: 304 YYDPEGKEDPHNEVDGDKTSKSEENSA-GIPE-DNGSQRIEDTQKLNHRESKRVENRITK 361
Query: 237 ATPKKTVPKKQ---VVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVP 293
+ V K Q + K P T++ + D+ + K V
Sbjct: 362 ESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVV 421
Query: 294 PPSAPPPKKSLGTQP-------------------PKKAVEKQQPVESSE-----DSSDES 329
P K G + K+++ P S E D++ ES
Sbjct: 422 NIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSES 481
Query: 330 DSSSEEEKKPPTKAVVSKATTKPPPAKKA----AESSSDSSDSDS-----SEDDEAPSKP 380
D++S + SK +K A ++S+SD+++SDS + +D+
Sbjct: 482 DNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSD 541
Query: 381 AGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKK 440
+G K+ S+ + S + + + +DS SS+ +SS S + +
Sbjct: 542 SGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNS----SSDSDSSDSDSSDSSDSDSSD 597
Query: 441 MVATTKPKATAKAALSLPAKQAPQGSRDSS-SDSDSSSSEEEEEKTSKSAVKKKPQKVAG 499
++ ++ ++ S + + DSS S+SDSS S+ + + + ++ +
Sbjct: 598 SSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSS 657
Query: 500 GAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKA 559
++ S +S ++SS+SSSS DSS + S ++ ++ +S + +
Sbjct: 658 DSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSD 717
Query: 560 AKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAET 597
+ NS + + ++ S S ++++ +++
Sbjct: 718 SSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDS 755
Score = 30.4 bits (67), Expect = 5.8
Identities = 41/235 (17%), Positives = 88/235 (37%), Gaps = 14/235 (5%)
Query: 465 GSRDSSSDSDS--SSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSS 522
GS +S+ + D +S E TS+ + ++ A P + + ++S+ S S
Sbjct: 188 GSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPS 247
Query: 523 DDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGS 582
+ ++E+E+ +G G + G ++ N K + + +E+ +++ +
Sbjct: 248 GNGADEDED--EGSGDDEDEEA---GNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSK 302
Query: 583 LKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADN 642
+ + E K K + + G +R + E V++R+
Sbjct: 303 EYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKE 362
Query: 643 SFDAKRGAAGDWG------ERANQVLKFTKGKSFRHEKTKKKRGSYRG-GSISVQ 690
S G + D G N+ + GK ++ K + G G G++ Q
Sbjct: 363 SETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQ 417
Score = 29.6 bits (65), Expect = 9.9
Identities = 41/228 (17%), Positives = 72/228 (31%), Gaps = 17/228 (7%)
Query: 320 ESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSK 379
E + + + + + E E P T + P+ A+ D D ED+EA
Sbjct: 212 EITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGADEDEDEGSGDD-EDEEA--- 267
Query: 380 PAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTK 439
G K+SSN Q G + +S S+E +E
Sbjct: 268 --GNGKDSSNNSK-----------GQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPH 314
Query: 440 KMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAG 499
V K + + + +P Q D+ + S E T +S +
Sbjct: 315 NEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDK 374
Query: 500 GAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKAN 547
G P+S + + + + + + GKG+ + Q N
Sbjct: 375 GIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVN 422
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 105 bits (263), Expect = 1e-22
Identities = 133/593 (22%), Positives = 214/593 (36%), Gaps = 71/593 (11%)
Query: 73 PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAV----PAKRVGLPPGKAAAKASESSS 128
P K+ A ++ E + +E K A PA P K ++
Sbjct: 262 PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT 321
Query: 129 SEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKIT 188
+E + +E P+ A AP K A ++ + ++ EP + +
Sbjct: 322 PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS 381
Query: 189 PVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSS--SDDSEEEKAAATPKK---TV 243
P T K + P ++AP A +++ S+ ++ S + +E A TPK+ T
Sbjct: 382 PTTPK---EPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTT 438
Query: 244 PKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPG-PYSSVPPPSAPP-PK 301
PKK A TTP + ++ KKP P P + P +AP PK
Sbjct: 439 PKKPAPTTPKEPAPTTPKEPAPTTT----------KKPAPTTPKEPAPTTPKETAPTTPK 488
Query: 302 KSLGTQPPKKAVEKQQ------PVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPP- 354
K T P K A + P E + + +E ++ EE P T + T K P
Sbjct: 489 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP 548
Query: 355 -AKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTT-KSPAVKPAA--APKQPV 410
K ++ + ++ + AP+ P GT + +PA TT K PA K A K+P
Sbjct: 549 TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 608
Query: 411 G---GGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAP---- 463
T K + ++ +E + + T K A T PK TA L PA P
Sbjct: 609 STTCDKPAPTTPKGTAPTTPKEPAPT----TPKEPAPTTPKGTAPTTLKEPAPTTPKKPA 664
Query: 464 ---------QGSRDSSSDSDSSSSEEEEEKTSKS----AVKKKP------------QKVA 498
+G ++SD + ++ +E T+ KKP +V+
Sbjct: 665 PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVS 724
Query: 499 GGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGK 558
+P + K ES+ S++ + + E K G P + P A T K
Sbjct: 725 TPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 784
Query: 559 AAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTF 611
+ E AA ++K + K E+ A T Q Q F
Sbjct: 785 TTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPF 837
Score = 103 bits (256), Expect = 7e-22
Identities = 113/567 (19%), Positives = 210/567 (37%), Gaps = 45/567 (7%)
Query: 67 KLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASES 126
K+ P+ + +S S+++S + K+ K+ + A E+
Sbjct: 117 KITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKET 176
Query: 127 SSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPK 186
S E++S D K KP KA A ++ + ++ EP +
Sbjct: 177 QSIEKTSAKDLAPTSKVL-----AKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKE 231
Query: 187 ITPVTVKAQTKAPPKPA----RAAPKIANGKAASSSSSSSSSSSSD---DSEEEKAAATP 239
TP T+K+ P +PA ++AP A +++ + ++ + + +E A T
Sbjct: 232 PTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 291
Query: 240 KK--TVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSA 297
K T PK+ A TTP + ++ + ++ P +P P ++ P+
Sbjct: 292 KSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP-TTPKEPAP 350
Query: 298 PPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKK 357
PKK T P + A P E + ++ E ++ +E P T T +P P
Sbjct: 351 TAPKKPAPTTPKEPA--PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT 408
Query: 358 AAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTT-KSPAVKPAAAPKQPVGGGQKL 416
+ ++ S ++ + AP+ P + KPA TT K PA PK+P
Sbjct: 409 KSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA---PTTPKEPA----PT 461
Query: 417 LTRKADSSSSEEESSSSEEE---KTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDS 473
T+K ++ +E + ++ +E T K + T P+ A PA P+ ++ +
Sbjct: 462 TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE 521
Query: 474 DSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPA---------SAKKGKAESSNSSSSDD 524
+ ++ EE T+ A K P +PA + K A ++ ++
Sbjct: 522 PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPT 581
Query: 525 SSEEEEEKLKGKGSPRPQAPKAN--------GTSALTAQNGKAAKNSEEEEEEKKKAAVV 576
+ +E K +P+ AP A T G A +E K
Sbjct: 582 TLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAP 641
Query: 577 VSKSGSLKKRKQNEAAKEAETPQAKKI 603
+ G+ + A + P K++
Sbjct: 642 TTPKGTAPTTLKEPAPTTPKKPAPKEL 668
Score = 70.5 bits (171), Expect = 5e-12
Identities = 84/416 (20%), Positives = 145/416 (34%), Gaps = 47/416 (11%)
Query: 75 AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSD 134
A ++ + + E+ + E P KAA P P K ++ +E +
Sbjct: 507 APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP--NTPKEPAPTTPKEPAPTTPKEPAP 564
Query: 135 DDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKA 194
+E P KG P AP K + + ++ EP K P T K
Sbjct: 565 TTPKETAPTTP--KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG 622
Query: 195 QTKAPPK------PARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAAT---------- 238
PK P AP G A ++ + ++ + +E A T
Sbjct: 623 TAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD 682
Query: 239 -PKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKP------GPYSS 291
P T PK+ A TTP + + ++ ++ E P K P S
Sbjct: 683 KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES 742
Query: 292 VPPPSAPPPKKSLGTQPPKKAVE--------KQQPVESSEDSSDESDSSSEEEKKPPTKA 343
P SA P K+L P + V K + +++D + E D + E
Sbjct: 743 TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 802
Query: 344 VVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAV--- 400
+ + T ++ +++ + + ++ D P K T K ++ P VTT +
Sbjct: 803 MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKIT-TLKTTTLAPKVTTTKKTITTT 861
Query: 401 ----KP--AAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKAT 450
KP A PK + + + + ++ +S+++ KT M KPK T
Sbjct: 862 EIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKT--MPRVRKPKTT 915
Score = 56.6 bits (135), Expect = 8e-08
Identities = 65/306 (21%), Positives = 108/306 (35%), Gaps = 28/306 (9%)
Query: 260 PTRKSSSSEDSSSDEEEEQKKPMKNKP-----------GPYSSVPPPSAPPPKKSLGTQP 308
P +S +E + + +KKP P G + P ++ + T P
Sbjct: 57 PDYESFCAEVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSP 116
Query: 309 PKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDS 368
+ P S +SD S +S K T TT + E ++ + ++
Sbjct: 117 KITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKET 176
Query: 369 DS----SEDDEAP-----SKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTR 419
S S D AP +KP + ++ PA+TT P PK+P K T
Sbjct: 177 QSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTT--PKEPTPTTPKEPASTTPKEPTP 234
Query: 420 KADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSE 479
S+ ++ E T A T PK A PA P+ +++ + ++
Sbjct: 235 TTIKSA---PTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 291
Query: 480 EEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSP 539
+ T K P+K A P +PA E + ++ + + +E P
Sbjct: 292 KSAPTTPKEPAPTTPKKPA-PTTPKEPAPTT--PKEPTPTTPKEPAPTTKEPAPTTPKEP 348
Query: 540 RPQAPK 545
P APK
Sbjct: 349 APTAPK 354
Score = 45.8 bits (107), Expect = 1e-04
Identities = 58/320 (18%), Positives = 113/320 (35%), Gaps = 24/320 (7%)
Query: 101 PAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEE----DQKKQPVQKGVKPQAKA 156
PA K P G P + K + ++ E + E +K P P +
Sbjct: 663 PAPKELAPTTTKG-PTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTS 721
Query: 157 AKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAAS 216
+ P K + S E P + +P T KA +P +P + K +
Sbjct: 722 EVSTPTTTKEPTTIHKSPDESTPELSAEP-----TPKALENSPKEPG-----VPTTKTPA 771
Query: 217 SSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEE 276
++ ++++ D + E TP+ T ++ + T K +++ +
Sbjct: 772 ATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTT 831
Query: 277 EQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEE 336
+ P K +++ P K T+ K E +P +D + S +++ +
Sbjct: 832 QDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKP----KDRATNSKATTPKP 887
Query: 337 KKP---PTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAV 393
+KP P K +K P +K + + + + + S+ A ++ +P
Sbjct: 888 QKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQ 947
Query: 394 TTKSPAVKPAAAPKQPVGGG 413
T S V+ PK GG
Sbjct: 948 TPNSKLVE--VNPKSEDAGG 965
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 105 bits (263), Expect = 1e-22
Identities = 133/593 (22%), Positives = 214/593 (36%), Gaps = 71/593 (11%)
Query: 73 PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAV----PAKRVGLPPGKAAAKASESSS 128
P K+ A ++ E + +E K A PA P K ++
Sbjct: 303 PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT 362
Query: 129 SEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKIT 188
+E + +E P+ A AP K A ++ + ++ EP + +
Sbjct: 363 PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS 422
Query: 189 PVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSS--SDDSEEEKAAATPKK---TV 243
P T K + P ++AP A +++ S+ ++ S + +E A TPK+ T
Sbjct: 423 PTTPK---EPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTT 479
Query: 244 PKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPG-PYSSVPPPSAPP-PK 301
PKK A TTP + ++ KKP P P + P +AP PK
Sbjct: 480 PKKPAPTTPKEPAPTTPKEPAPTTT----------KKPAPTTPKEPAPTTPKETAPTTPK 529
Query: 302 KSLGTQPPKKAVEKQQ------PVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPP- 354
K T P K A + P E + + +E ++ EE P T + T K P
Sbjct: 530 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP 589
Query: 355 -AKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTT-KSPAVKPAA--APKQPV 410
K ++ + ++ + AP+ P GT + +PA TT K PA K A K+P
Sbjct: 590 TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 649
Query: 411 G---GGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAP---- 463
T K + ++ +E + + T K A T PK TA L PA P
Sbjct: 650 STTCDKPAPTTPKGTAPTTPKEPAPT----TPKEPAPTTPKGTAPTTLKEPAPTTPKKPA 705
Query: 464 ---------QGSRDSSSDSDSSSSEEEEEKTSKS----AVKKKP------------QKVA 498
+G ++SD + ++ +E T+ KKP +V+
Sbjct: 706 PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVS 765
Query: 499 GGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGK 558
+P + K ES+ S++ + + E K G P + P A T K
Sbjct: 766 TPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 825
Query: 559 AAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTF 611
+ E AA ++K + K E+ A T Q Q F
Sbjct: 826 TTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPF 878
Score = 103 bits (256), Expect = 7e-22
Identities = 113/567 (19%), Positives = 210/567 (37%), Gaps = 45/567 (7%)
Query: 67 KLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASES 126
K+ P+ + +S S+++S + K+ K+ + A E+
Sbjct: 158 KITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKET 217
Query: 127 SSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPK 186
S E++S D K KP KA A ++ + ++ EP +
Sbjct: 218 QSIEKTSAKDLAPTSKVL-----AKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKE 272
Query: 187 ITPVTVKAQTKAPPKPA----RAAPKIANGKAASSSSSSSSSSSSD---DSEEEKAAATP 239
TP T+K+ P +PA ++AP A +++ + ++ + + +E A T
Sbjct: 273 PTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 332
Query: 240 KK--TVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSA 297
K T PK+ A TTP + ++ + ++ P +P P ++ P+
Sbjct: 333 KSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP-TTPKEPAP 391
Query: 298 PPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKK 357
PKK T P + A P E + ++ E ++ +E P T T +P P
Sbjct: 392 TAPKKPAPTTPKEPA--PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT 449
Query: 358 AAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTT-KSPAVKPAAAPKQPVGGGQKL 416
+ ++ S ++ + AP+ P + KPA TT K PA PK+P
Sbjct: 450 KSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA---PTTPKEPA----PT 502
Query: 417 LTRKADSSSSEEESSSSEEE---KTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDS 473
T+K ++ +E + ++ +E T K + T P+ A PA P+ ++ +
Sbjct: 503 TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE 562
Query: 474 DSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPA---------SAKKGKAESSNSSSSDD 524
+ ++ EE T+ A K P +PA + K A ++ ++
Sbjct: 563 PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPT 622
Query: 525 SSEEEEEKLKGKGSPRPQAPKAN--------GTSALTAQNGKAAKNSEEEEEEKKKAAVV 576
+ +E K +P+ AP A T G A +E K
Sbjct: 623 TLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAP 682
Query: 577 VSKSGSLKKRKQNEAAKEAETPQAKKI 603
+ G+ + A + P K++
Sbjct: 683 TTPKGTAPTTLKEPAPTTPKKPAPKEL 709
Score = 70.5 bits (171), Expect = 5e-12
Identities = 84/416 (20%), Positives = 145/416 (34%), Gaps = 47/416 (11%)
Query: 75 AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSD 134
A ++ + + E+ + E P KAA P P K ++ +E +
Sbjct: 548 APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP--NTPKEPAPTTPKEPAPTTPKEPAP 605
Query: 135 DDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKA 194
+E P KG P AP K + + ++ EP K P T K
Sbjct: 606 TTPKETAPTTP--KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG 663
Query: 195 QTKAPPK------PARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAAT---------- 238
PK P AP G A ++ + ++ + +E A T
Sbjct: 664 TAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD 723
Query: 239 -PKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKP------GPYSS 291
P T PK+ A TTP + + ++ ++ E P K P S
Sbjct: 724 KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES 783
Query: 292 VPPPSAPPPKKSLGTQPPKKAVE--------KQQPVESSEDSSDESDSSSEEEKKPPTKA 343
P SA P K+L P + V K + +++D + E D + E
Sbjct: 784 TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 843
Query: 344 VVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAV--- 400
+ + T ++ +++ + + ++ D P K T K ++ P VTT +
Sbjct: 844 MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKIT-TLKTTTLAPKVTTTKKTITTT 902
Query: 401 ----KP--AAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKAT 450
KP A PK + + + + ++ +S+++ KT M KPK T
Sbjct: 903 EIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKT--MPRVRKPKTT 956
Score = 56.6 bits (135), Expect = 8e-08
Identities = 65/306 (21%), Positives = 108/306 (35%), Gaps = 28/306 (9%)
Query: 260 PTRKSSSSEDSSSDEEEEQKKPMKNKP-----------GPYSSVPPPSAPPPKKSLGTQP 308
P +S +E + + +KKP P G + P ++ + T P
Sbjct: 98 PDYESFCAEVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSP 157
Query: 309 PKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDS 368
+ P S +SD S +S K T TT + E ++ + ++
Sbjct: 158 KITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKET 217
Query: 369 DS----SEDDEAP-----SKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTR 419
S S D AP +KP + ++ PA+TT P PK+P K T
Sbjct: 218 QSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTT--PKEPTPTTPKEPASTTPKEPTP 275
Query: 420 KADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSE 479
S+ ++ E T A T PK A PA P+ +++ + ++
Sbjct: 276 TTIKSA---PTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 332
Query: 480 EEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSP 539
+ T K P+K A P +PA E + ++ + + +E P
Sbjct: 333 KSAPTTPKEPAPTTPKKPA-PTTPKEPAPTT--PKEPTPTTPKEPAPTTKEPAPTTPKEP 389
Query: 540 RPQAPK 545
P APK
Sbjct: 390 APTAPK 395
Score = 45.8 bits (107), Expect = 1e-04
Identities = 58/320 (18%), Positives = 113/320 (35%), Gaps = 24/320 (7%)
Query: 101 PAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEE----DQKKQPVQKGVKPQAKA 156
PA K P G P + K + ++ E + E +K P P +
Sbjct: 704 PAPKELAPTTTKG-PTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTS 762
Query: 157 AKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAAS 216
+ P K + S E P + +P T KA +P +P + K +
Sbjct: 763 EVSTPTTTKEPTTIHKSPDESTPELSAEP-----TPKALENSPKEPG-----VPTTKTPA 812
Query: 217 SSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEE 276
++ ++++ D + E TP+ T ++ + T K +++ +
Sbjct: 813 ATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTT 872
Query: 277 EQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEE 336
+ P K +++ P K T+ K E +P +D + S +++ +
Sbjct: 873 QDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKP----KDRATNSKATTPKP 928
Query: 337 KKP---PTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAV 393
+KP P K +K P +K + + + + + S+ A ++ +P
Sbjct: 929 QKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQ 988
Query: 394 TTKSPAVKPAAAPKQPVGGG 413
T S V+ PK GG
Sbjct: 989 TPNSKLVE--VNPKSEDAGG 1006
>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
Length = 1363
Score = 105 bits (263), Expect = 1e-22
Identities = 133/593 (22%), Positives = 214/593 (36%), Gaps = 71/593 (11%)
Query: 73 PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAV----PAKRVGLPPGKAAAKASESSS 128
P K+ A ++ E + +E K A PA P K ++
Sbjct: 355 PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT 414
Query: 129 SEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKIT 188
+E + +E P+ A AP K A ++ + ++ EP + +
Sbjct: 415 PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS 474
Query: 189 PVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSS--SDDSEEEKAAATPKK---TV 243
P T K + P ++AP A +++ S+ ++ S + +E A TPK+ T
Sbjct: 475 PTTPK---EPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTT 531
Query: 244 PKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPG-PYSSVPPPSAPP-PK 301
PKK A TTP + ++ KKP P P + P +AP PK
Sbjct: 532 PKKPAPTTPKEPAPTTPKEPAPTTT----------KKPAPTTPKEPAPTTPKETAPTTPK 581
Query: 302 KSLGTQPPKKAVEKQQ------PVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPP- 354
K T P K A + P E + + +E ++ EE P T + T K P
Sbjct: 582 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP 641
Query: 355 -AKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTT-KSPAVKPAA--APKQPV 410
K ++ + ++ + AP+ P GT + +PA TT K PA K A K+P
Sbjct: 642 TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 701
Query: 411 G---GGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAP---- 463
T K + ++ +E + + T K A T PK TA L PA P
Sbjct: 702 STTCDKPAPTTPKGTAPTTPKEPAPT----TPKEPAPTTPKGTAPTTLKEPAPTTPKKPA 757
Query: 464 ---------QGSRDSSSDSDSSSSEEEEEKTSKS----AVKKKP------------QKVA 498
+G ++SD + ++ +E T+ KKP +V+
Sbjct: 758 PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVS 817
Query: 499 GGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGK 558
+P + K ES+ S++ + + E K G P + P A T K
Sbjct: 818 TPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 877
Query: 559 AAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTF 611
+ E AA ++K + K E+ A T Q Q F
Sbjct: 878 TTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPF 930
Score = 103 bits (256), Expect = 7e-22
Identities = 113/567 (19%), Positives = 210/567 (37%), Gaps = 45/567 (7%)
Query: 67 KLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASES 126
K+ P+ + +S S+++S + K+ K+ + A E+
Sbjct: 210 KITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKET 269
Query: 127 SSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPK 186
S E++S D K KP KA A ++ + ++ EP +
Sbjct: 270 QSIEKTSAKDLAPTSKVL-----AKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKE 324
Query: 187 ITPVTVKAQTKAPPKPA----RAAPKIANGKAASSSSSSSSSSSSD---DSEEEKAAATP 239
TP T+K+ P +PA ++AP A +++ + ++ + + +E A T
Sbjct: 325 PTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 384
Query: 240 KK--TVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSA 297
K T PK+ A TTP + ++ + ++ P +P P ++ P+
Sbjct: 385 KSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP-TTPKEPAP 443
Query: 298 PPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKK 357
PKK T P + A P E + ++ E ++ +E P T T +P P
Sbjct: 444 TAPKKPAPTTPKEPA--PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT 501
Query: 358 AAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTT-KSPAVKPAAAPKQPVGGGQKL 416
+ ++ S ++ + AP+ P + KPA TT K PA PK+P
Sbjct: 502 KSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA---PTTPKEPA----PT 554
Query: 417 LTRKADSSSSEEESSSSEEE---KTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDS 473
T+K ++ +E + ++ +E T K + T P+ A PA P+ ++ +
Sbjct: 555 TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE 614
Query: 474 DSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPA---------SAKKGKAESSNSSSSDD 524
+ ++ EE T+ A K P +PA + K A ++ ++
Sbjct: 615 PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPT 674
Query: 525 SSEEEEEKLKGKGSPRPQAPKAN--------GTSALTAQNGKAAKNSEEEEEEKKKAAVV 576
+ +E K +P+ AP A T G A +E K
Sbjct: 675 TLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAP 734
Query: 577 VSKSGSLKKRKQNEAAKEAETPQAKKI 603
+ G+ + A + P K++
Sbjct: 735 TTPKGTAPTTLKEPAPTTPKKPAPKEL 761
Score = 79.0 bits (193), Expect = 1e-14
Identities = 113/510 (22%), Positives = 183/510 (35%), Gaps = 74/510 (14%)
Query: 164 AKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPA--RAAPKIA----------- 210
A+ + S SS+ PP P T+K+ TK PKP + K+
Sbjct: 64 AEVHNPTSPPSSKKAPP----PSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSV 119
Query: 211 --NGKAASSSSSSSSSS------SSDDS------------EEEKAAATPKKTVPKKQVVA 250
N +++SSSSSSSSSS SS +S ++ K T KK PK VV
Sbjct: 120 SENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVD 179
Query: 251 KAPVK------AATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSL 304
+A TTP ++ S+ + KP+ +P S+PP S + SL
Sbjct: 180 EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRP----SLPPNSDTSKETSL 235
Query: 305 GTQPPKKAVEKQQPVESSEDSSD--ESDSSSEEEKK---------PPTKAVVSKATTKPP 353
K+ + + S+D E +S++E + PT V++K T K
Sbjct: 236 TVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAE 295
Query: 354 PAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPA-VKPAAAPKQPVGG 412
K ++ + ++ + A + P T + T K PA +AP P
Sbjct: 296 TTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEP 355
Query: 413 GQKLLTRKADSSSSEEESSSSEE---------EKTKKMVATTKPKATAKAALSLPAKQAP 463
A ++ E ++++E T K A T PK A PA P
Sbjct: 356 APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTP 415
Query: 464 QGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSD 523
+ ++ + +++E T K P+K A P +PA + + +
Sbjct: 416 KEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA-PTTPKEPAPTTPKEPAPTTTKEPS 474
Query: 524 DSSEEEEEKLKGKGSP---RPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSK- 579
++ +E K +P + AP ++ T + E K+ A K
Sbjct: 475 PTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKK 534
Query: 580 -SGSLKKRKQNEAAKEAETPQAKKIKLQTP 608
+ + K KE KK TP
Sbjct: 535 PAPTTPKEPAPTTPKEPAPTTTKKPAPTTP 564
Score = 79.0 bits (193), Expect = 1e-14
Identities = 112/530 (21%), Positives = 184/530 (34%), Gaps = 94/530 (17%)
Query: 73 PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAA---------VPAKRVGLPPGKAAAKA 123
P +KKA + +S + S+ + PP KK V +++ +
Sbjct: 73 PSSKKAPPPSGASQTIKSTTKRSPK--PPNKKKTKKVIESEEITEEHSVSENQESSSSSS 130
Query: 124 SESSSS------EESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKA------------- 164
S SSSS + + E QKK V+ K + K P
Sbjct: 131 SSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDF 190
Query: 165 KSSDSDSDSSSEDE-------------------PPKNQKPKITPVTVKAQTKAPPKPARA 205
K + D+ ++ ++ PP + K T +TV +T K
Sbjct: 191 KVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTT 250
Query: 206 APKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK---KTVPKKQVVAKAPVKAATTPTR 262
K + ++S+ + S + + + A T K K PK + K P A TTP
Sbjct: 251 TNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP--ALTTPKE 308
Query: 263 KSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESS 322
+ ++ + ++ P K P + P AP KS T P E +
Sbjct: 309 PTPTTPKEPASTTPKEPTPTTIKSAP--TTPKEPAPTTTKSAPTTPK----------EPA 356
Query: 323 EDSSDESDSSSEEEKKPPTKAVVSKATTK-PPPAKKAAESSSDSSDSDSSEDDEAPSKPA 381
++ E ++ +E P T + TTK P K ++ + ++ + AP+ P
Sbjct: 357 PTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPK 416
Query: 382 GTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKM 441
T + +PA TTK PA PK+P K T K
Sbjct: 417 EPTPTTPKEPAPTTKEPA---PTTPKEPAPTAPK-----------------KPAPTTPKE 456
Query: 442 VATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSA--VKKKPQ---- 495
A T PK A P+ P+ +++ S ++++E T+KSA K+P
Sbjct: 457 PAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT 516
Query: 496 KVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPK 545
K P +PA K + ++ +E K P P PK
Sbjct: 517 KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK-KPAPTTPK 565
Score = 70.5 bits (171), Expect = 5e-12
Identities = 84/416 (20%), Positives = 145/416 (34%), Gaps = 47/416 (11%)
Query: 75 AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSD 134
A ++ + + E+ + E P KAA P P K ++ +E +
Sbjct: 600 APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP--NTPKEPAPTTPKEPAPTTPKEPAP 657
Query: 135 DDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKA 194
+E P KG P AP K + + ++ EP K P T K
Sbjct: 658 TTPKETAPTTP--KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG 715
Query: 195 QTKAPPK------PARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAAT---------- 238
PK P AP G A ++ + ++ + +E A T
Sbjct: 716 TAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD 775
Query: 239 -PKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKP------GPYSS 291
P T PK+ A TTP + + ++ ++ E P K P S
Sbjct: 776 KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES 835
Query: 292 VPPPSAPPPKKSLGTQPPKKAVE--------KQQPVESSEDSSDESDSSSEEEKKPPTKA 343
P SA P K+L P + V K + +++D + E D + E
Sbjct: 836 TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 895
Query: 344 VVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAV--- 400
+ + T ++ +++ + + ++ D P K T K ++ P VTT +
Sbjct: 896 MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKIT-TLKTTTLAPKVTTTKKTITTT 954
Query: 401 ----KP--AAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKAT 450
KP A PK + + + + ++ +S+++ KT M KPK T
Sbjct: 955 EIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKT--MPRVRKPKTT 1008
Score = 45.8 bits (107), Expect = 1e-04
Identities = 58/320 (18%), Positives = 113/320 (35%), Gaps = 24/320 (7%)
Query: 101 PAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEE----DQKKQPVQKGVKPQAKA 156
PA K P G P + K + ++ E + E +K P P +
Sbjct: 756 PAPKELAPTTTKG-PTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTS 814
Query: 157 AKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAAS 216
+ P K + S E P + +P T KA +P +P + K +
Sbjct: 815 EVSTPTTTKEPTTIHKSPDESTPELSAEP-----TPKALENSPKEPG-----VPTTKTPA 864
Query: 217 SSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEE 276
++ ++++ D + E TP+ T ++ + T K +++ +
Sbjct: 865 ATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTT 924
Query: 277 EQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEE 336
+ P K +++ P K T+ K E +P +D + S +++ +
Sbjct: 925 QDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKP----KDRATNSKATTPKP 980
Query: 337 KKP---PTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAV 393
+KP P K +K P +K + + + + + S+ A ++ +P
Sbjct: 981 QKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQ 1040
Query: 394 TTKSPAVKPAAAPKQPVGGG 413
T S V+ PK GG
Sbjct: 1041 TPNSKLVE--VNPKSEDAGG 1058
>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
Length = 1404
Score = 105 bits (263), Expect = 1e-22
Identities = 133/593 (22%), Positives = 214/593 (36%), Gaps = 71/593 (11%)
Query: 73 PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAV----PAKRVGLPPGKAAAKASESSS 128
P K+ A ++ E + +E K A PA P K ++
Sbjct: 396 PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT 455
Query: 129 SEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKIT 188
+E + +E P+ A AP K A ++ + ++ EP + +
Sbjct: 456 PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS 515
Query: 189 PVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSS--SDDSEEEKAAATPKK---TV 243
P T K + P ++AP A +++ S+ ++ S + +E A TPK+ T
Sbjct: 516 PTTPK---EPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTT 572
Query: 244 PKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPG-PYSSVPPPSAPP-PK 301
PKK A TTP + ++ KKP P P + P +AP PK
Sbjct: 573 PKKPAPTTPKEPAPTTPKEPAPTTT----------KKPAPTTPKEPAPTTPKETAPTTPK 622
Query: 302 KSLGTQPPKKAVEKQQ------PVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPP- 354
K T P K A + P E + + +E ++ EE P T + T K P
Sbjct: 623 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP 682
Query: 355 -AKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTT-KSPAVKPAA--APKQPV 410
K ++ + ++ + AP+ P GT + +PA TT K PA K A K+P
Sbjct: 683 TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 742
Query: 411 G---GGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAP---- 463
T K + ++ +E + + T K A T PK TA L PA P
Sbjct: 743 STTCDKPAPTTPKGTAPTTPKEPAPT----TPKEPAPTTPKGTAPTTLKEPAPTTPKKPA 798
Query: 464 ---------QGSRDSSSDSDSSSSEEEEEKTSKS----AVKKKP------------QKVA 498
+G ++SD + ++ +E T+ KKP +V+
Sbjct: 799 PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVS 858
Query: 499 GGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGK 558
+P + K ES+ S++ + + E K G P + P A T K
Sbjct: 859 TPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 918
Query: 559 AAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTF 611
+ E AA ++K + K E+ A T Q Q F
Sbjct: 919 TTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPF 971
Score = 103 bits (256), Expect = 7e-22
Identities = 113/567 (19%), Positives = 210/567 (37%), Gaps = 45/567 (7%)
Query: 67 KLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASES 126
K+ P+ + +S S+++S + K+ K+ + A E+
Sbjct: 251 KITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKET 310
Query: 127 SSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPK 186
S E++S D K KP KA A ++ + ++ EP +
Sbjct: 311 QSIEKTSAKDLAPTSKVL-----AKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKE 365
Query: 187 ITPVTVKAQTKAPPKPA----RAAPKIANGKAASSSSSSSSSSSSD---DSEEEKAAATP 239
TP T+K+ P +PA ++AP A +++ + ++ + + +E A T
Sbjct: 366 PTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 425
Query: 240 KK--TVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSA 297
K T PK+ A TTP + ++ + ++ P +P P ++ P+
Sbjct: 426 KSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP-TTPKEPAP 484
Query: 298 PPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKK 357
PKK T P + A P E + ++ E ++ +E P T T +P P
Sbjct: 485 TAPKKPAPTTPKEPA--PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT 542
Query: 358 AAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTT-KSPAVKPAAAPKQPVGGGQKL 416
+ ++ S ++ + AP+ P + KPA TT K PA PK+P
Sbjct: 543 KSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA---PTTPKEPA----PT 595
Query: 417 LTRKADSSSSEEESSSSEEE---KTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDS 473
T+K ++ +E + ++ +E T K + T P+ A PA P+ ++ +
Sbjct: 596 TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE 655
Query: 474 DSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPA---------SAKKGKAESSNSSSSDD 524
+ ++ EE T+ A K P +PA + K A ++ ++
Sbjct: 656 PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPT 715
Query: 525 SSEEEEEKLKGKGSPRPQAPKAN--------GTSALTAQNGKAAKNSEEEEEEKKKAAVV 576
+ +E K +P+ AP A T G A +E K
Sbjct: 716 TLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAP 775
Query: 577 VSKSGSLKKRKQNEAAKEAETPQAKKI 603
+ G+ + A + P K++
Sbjct: 776 TTPKGTAPTTLKEPAPTTPKKPAPKEL 802
Score = 79.0 bits (193), Expect = 1e-14
Identities = 113/510 (22%), Positives = 183/510 (35%), Gaps = 74/510 (14%)
Query: 164 AKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPA--RAAPKIA----------- 210
A+ + S SS+ PP P T+K+ TK PKP + K+
Sbjct: 105 AEVHNPTSPPSSKKAPP----PSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSV 160
Query: 211 --NGKAASSSSSSSSSS------SSDDS------------EEEKAAATPKKTVPKKQVVA 250
N +++SSSSSSSSSS SS +S ++ K T KK PK VV
Sbjct: 161 SENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVD 220
Query: 251 KAPVK------AATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSL 304
+A TTP ++ S+ + KP+ +P S+PP S + SL
Sbjct: 221 EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRP----SLPPNSDTSKETSL 276
Query: 305 GTQPPKKAVEKQQPVESSEDSSD--ESDSSSEEEKK---------PPTKAVVSKATTKPP 353
K+ + + S+D E +S++E + PT V++K T K
Sbjct: 277 TVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAE 336
Query: 354 PAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPA-VKPAAAPKQPVGG 412
K ++ + ++ + A + P T + T K PA +AP P
Sbjct: 337 TTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEP 396
Query: 413 GQKLLTRKADSSSSEEESSSSEE---------EKTKKMVATTKPKATAKAALSLPAKQAP 463
A ++ E ++++E T K A T PK A PA P
Sbjct: 397 APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTP 456
Query: 464 QGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSD 523
+ ++ + +++E T K P+K A P +PA + + +
Sbjct: 457 KEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA-PTTPKEPAPTTPKEPAPTTTKEPS 515
Query: 524 DSSEEEEEKLKGKGSP---RPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSK- 579
++ +E K +P + AP ++ T + E K+ A K
Sbjct: 516 PTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKK 575
Query: 580 -SGSLKKRKQNEAAKEAETPQAKKIKLQTP 608
+ + K KE KK TP
Sbjct: 576 PAPTTPKEPAPTTPKEPAPTTTKKPAPTTP 605
Score = 79.0 bits (193), Expect = 1e-14
Identities = 112/530 (21%), Positives = 184/530 (34%), Gaps = 94/530 (17%)
Query: 73 PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAA---------VPAKRVGLPPGKAAAKA 123
P +KKA + +S + S+ + PP KK V +++ +
Sbjct: 114 PSSKKAPPPSGASQTIKSTTKRSPK--PPNKKKTKKVIESEEITEEHSVSENQESSSSSS 171
Query: 124 SESSSS------EESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKA------------- 164
S SSSS + + E QKK V+ K + K P
Sbjct: 172 SSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDF 231
Query: 165 KSSDSDSDSSSEDE-------------------PPKNQKPKITPVTVKAQTKAPPKPARA 205
K + D+ ++ ++ PP + K T +TV +T K
Sbjct: 232 KVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTT 291
Query: 206 APKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK---KTVPKKQVVAKAPVKAATTPTR 262
K + ++S+ + S + + + A T K K PK + K P A TTP
Sbjct: 292 TNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP--ALTTPKE 349
Query: 263 KSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESS 322
+ ++ + ++ P K P + P AP KS T P E +
Sbjct: 350 PTPTTPKEPASTTPKEPTPTTIKSAP--TTPKEPAPTTTKSAPTTPK----------EPA 397
Query: 323 EDSSDESDSSSEEEKKPPTKAVVSKATTK-PPPAKKAAESSSDSSDSDSSEDDEAPSKPA 381
++ E ++ +E P T + TTK P K ++ + ++ + AP+ P
Sbjct: 398 PTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPK 457
Query: 382 GTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKM 441
T + +PA TTK PA PK+P K T K
Sbjct: 458 EPTPTTPKEPAPTTKEPA---PTTPKEPAPTAPK-----------------KPAPTTPKE 497
Query: 442 VATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSA--VKKKPQ---- 495
A T PK A P+ P+ +++ S ++++E T+KSA K+P
Sbjct: 498 PAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT 557
Query: 496 KVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPK 545
K P +PA K + ++ +E K P P PK
Sbjct: 558 KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK-KPAPTTPK 606
Score = 70.5 bits (171), Expect = 5e-12
Identities = 84/416 (20%), Positives = 145/416 (34%), Gaps = 47/416 (11%)
Query: 75 AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSD 134
A ++ + + E+ + E P KAA P P K ++ +E +
Sbjct: 641 APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP--NTPKEPAPTTPKEPAPTTPKEPAP 698
Query: 135 DDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKA 194
+E P KG P AP K + + ++ EP K P T K
Sbjct: 699 TTPKETAPTTP--KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG 756
Query: 195 QTKAPPK------PARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAAT---------- 238
PK P AP G A ++ + ++ + +E A T
Sbjct: 757 TAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD 816
Query: 239 -PKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKP------GPYSS 291
P T PK+ A TTP + + ++ ++ E P K P S
Sbjct: 817 KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES 876
Query: 292 VPPPSAPPPKKSLGTQPPKKAVE--------KQQPVESSEDSSDESDSSSEEEKKPPTKA 343
P SA P K+L P + V K + +++D + E D + E
Sbjct: 877 TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 936
Query: 344 VVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAV--- 400
+ + T ++ +++ + + ++ D P K T K ++ P VTT +
Sbjct: 937 MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKIT-TLKTTTLAPKVTTTKKTITTT 995
Query: 401 ----KP--AAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKAT 450
KP A PK + + + + ++ +S+++ KT M KPK T
Sbjct: 996 EIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKT--MPRVRKPKTT 1049
Score = 45.8 bits (107), Expect = 1e-04
Identities = 58/320 (18%), Positives = 113/320 (35%), Gaps = 24/320 (7%)
Query: 101 PAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEE----DQKKQPVQKGVKPQAKA 156
PA K P G P + K + ++ E + E +K P P +
Sbjct: 797 PAPKELAPTTTKG-PTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTS 855
Query: 157 AKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAAS 216
+ P K + S E P + +P T KA +P +P + K +
Sbjct: 856 EVSTPTTTKEPTTIHKSPDESTPELSAEP-----TPKALENSPKEPG-----VPTTKTPA 905
Query: 217 SSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEE 276
++ ++++ D + E TP+ T ++ + T K +++ +
Sbjct: 906 ATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTT 965
Query: 277 EQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEE 336
+ P K +++ P K T+ K E +P +D + S +++ +
Sbjct: 966 QDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKP----KDRATNSKATTPKP 1021
Query: 337 KKP---PTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAV 393
+KP P K +K P +K + + + + + S+ A ++ +P
Sbjct: 1022 QKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQ 1081
Query: 394 TTKSPAVKPAAAPKQPVGGG 413
T S V+ PK GG
Sbjct: 1082 TPNSKLVE--VNPKSEDAGG 1099
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 105 bits (262), Expect = 1e-22
Identities = 143/593 (24%), Positives = 233/593 (39%), Gaps = 82/593 (13%)
Query: 34 FAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEE 93
+AK+ G T +A A + L S KV ++ +++ + + S+ ED +
Sbjct: 866 WAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDP 925
Query: 94 EEEVQ-GPPAKKAAVPAKRV---GLPPGKA----AAKASESSSSEESSDDDDEEDQKKQP 145
E+E + G P + P KR G GK A + +S+ESS + DEED ++
Sbjct: 926 EQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDE 985
Query: 146 VQKGVKPQAKAAKAPPKKAKSSDSDSDSSSE-----DEPPKNQKPKITPVTVKAQTKAPP 200
+ + K + + D +SDSSS+ D +N T +++ +
Sbjct: 986 EDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDS------TSDSESSSSS 1039
Query: 201 KPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKA-ATT 259
+ ++ ++ ++SSSSSSS SSS D+ EEE+ AA P + P ++V P
Sbjct: 1040 SSSSSS---SSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPV 1096
Query: 260 PTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAP--PPKKSLGTQPPKKAVEKQQ 317
P R + S ++E +P GP + PPSAP PP+ G PP A
Sbjct: 1097 PERVAGSPVTPLPEQEASPARP----AGP-TEESPPSAPLRPPEPPAG--PPAPA----- 1144
Query: 318 PVESSEDSSDESDSSSEEEKKPPTK--AVVSKATTKPPPAKKAAESSSDSSDSDSSEDDE 375
DE SS PP K VS + + PA + ++ + +
Sbjct: 1145 ------PRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRK 1198
Query: 376 APSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEE 435
AP T +N A KS + + + GG +L + EEE+ E
Sbjct: 1199 APRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRL--------TEEEEA----E 1246
Query: 436 EKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEK----------T 485
T+ +A A A LPA A + DS+++ + +E E+
Sbjct: 1247 PGTEVDLAVLADLALTPARRGLPALPAVE-------DSEATETSDEAERPRPLLSHILLE 1299
Query: 486 SKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPK 545
A+ KP A P +P A + SS +D+ E E + P+PQ +
Sbjct: 1300 HNYALAVKPTPPAPALRPPEPVPA----PAALFSSPADEVLEAPEVVVAEAEEPKPQQLQ 1355
Query: 546 ANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETP 598
+ + EEEEEE ++ G+L++R A+ P
Sbjct: 1356 QQREEG----EEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPP 1404
Score = 78.6 bits (192), Expect = 2e-14
Identities = 105/472 (22%), Positives = 174/472 (36%), Gaps = 48/472 (10%)
Query: 66 RKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASE 125
RK A ++A +++SS E+ EE+EE + ++ AV + + S+
Sbjct: 956 RKSFALDSEGEEASQESSSEKDEEDDEEDEEDED---REEAVDTTKKETEVSDGEDEESD 1012
Query: 126 SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDE------- 178
SSS D D E+ + + ++ + + SS S S+SSSEDE
Sbjct: 1013 SSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPA 1072
Query: 179 ------PPKNQKPKIT--PVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDS 230
PP + P T PV V + P P+ A + + S S+
Sbjct: 1073 ALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLR 1132
Query: 231 EEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKS-----SSSEDSSSDEEEEQKKPMKNK 285
E A P P+ +P+ P ++ S+ E + E P
Sbjct: 1133 PPEPPAG-PPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKF 1191
Query: 286 PGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDS----SSEEEKKPPT 341
PGP S P ++L ++ K P E S + + EEE +P T
Sbjct: 1192 PGPASRKAPRGVERTIRNLPLD--HASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGT 1249
Query: 342 K---AVVSKATTKPP----PAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVT 394
+ AV++ P PA A E DS +++S++ E P +P + + A+
Sbjct: 1250 EVDLAVLADLALTPARRGLPALPAVE---DSEATETSDEAERP-RPLLSHILLEHNYALA 1305
Query: 395 TKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAA 454
K PA P +PV L + AD E +E E+ KP+ +
Sbjct: 1306 VKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEE-------PKPQQLQQQR 1358
Query: 455 LSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKP 506
+ +G + SDSSSS + E + +++ ++ P P
Sbjct: 1359 EEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPPPPPP 1410
Score = 55.5 bits (132), Expect = 2e-07
Identities = 72/380 (18%), Positives = 127/380 (33%), Gaps = 12/380 (3%)
Query: 62 KVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAA 121
K K Q +G + A+ + SS + G P ++ +
Sbjct: 198 KALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPC-SQDTSFSSSRQDT 256
Query: 122 KASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPK 181
+S + +SS + P + + K +S +S D+ S
Sbjct: 257 PSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSA 316
Query: 182 NQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDS----EEEKAAA 237
+ + A T A + ++ +++ ++SSSSSSS SSD + E
Sbjct: 317 SSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRY 376
Query: 238 TPKKTVPKKQVVAKAPVKA--ATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPP 295
+ P ++ + P A A + S S E + +P P S PPP
Sbjct: 377 QRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRP-PASEAPPP 435
Query: 296 SAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPA 355
P P G P E+ + + + E + A S ++
Sbjct: 436 EPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEML 495
Query: 356 KKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPK----QPVG 411
K S SD+ E++E S G S P+ + P P A P G
Sbjct: 496 LKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTG 555
Query: 412 GGQKLLTRKADSSSSEEESS 431
G+ TR++ ++ + ++S
Sbjct: 556 SGEPGATRESPKANGQNQAS 575
Score = 48.5 bits (114), Expect = 2e-05
Identities = 80/388 (20%), Positives = 148/388 (38%), Gaps = 35/388 (9%)
Query: 253 PVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKP--GPYSSVPPPSAPPPKKSLGTQPPK 310
P+ A P+ S E EE + K P G V K + +
Sbjct: 753 PMAAEPLPSSSVSGEEARLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNR 812
Query: 311 KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAE----SSSDSS 366
K VE + + D+ S EE+ KP A +A + K E S D +
Sbjct: 813 KMVENV-----AFGAFDQWWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWA 867
Query: 367 DSDSSEDDEAPSKPAGTTKNSSNKPA--VTTKSPA-VKPAAAPKQPVGGGQKLLTRKADS 423
S + EA + +G + + P+ V K P+ + A+ K+P R +
Sbjct: 868 KSGGTTGIEAFAFGSGL-RGALRLPSFKVKRKEPSEISEASEEKRP---------RPSTP 917
Query: 424 SSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDS---DSSSSEE 480
+ +E+ E+E + TKP + K + DS + +SSS ++
Sbjct: 918 AEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKD 977
Query: 481 EEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSS----DDSSEEEEEKLKGK 536
EE+ + + + V K G+ E S+SSS DS E + +
Sbjct: 978 EEDDEEDEEDEDREEAV---DTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSE 1034
Query: 537 GSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAE 596
S + ++ +S+ ++ + ++++S E+EEE+++ A + S S ++ A E
Sbjct: 1035 SSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPA-PVE 1093
Query: 597 TPQAKKIKLQTPNTFPKRKKGEKRASSP 624
P +++ P+++ R + P
Sbjct: 1094 VPVPERVAGSPVTPLPEQEASPARPAGP 1121
Score = 38.9 bits (89), Expect = 0.016
Identities = 52/256 (20%), Positives = 92/256 (35%), Gaps = 25/256 (9%)
Query: 73 PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVG----------LPPGKAAA- 121
P KK +K S S E E PP K PA R LP A+
Sbjct: 1159 PPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLV 1218
Query: 122 -----KASESSSSEESSDDDDEEDQKKQP-VQKGVKPQAKAAKAPPKK---AKSSDSDSD 172
+ S S E+++ +P + + A A P ++ A + DS+
Sbjct: 1219 KSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSE 1278
Query: 173 SSSEDEPPKNQKPKITPVTVK-----AQTKAPPKPARAAPKIANGKAASSSSSSSSSSSS 227
++ + + +P ++ + ++ A PP PA P+ AA SS + +
Sbjct: 1279 ATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEA 1338
Query: 228 DDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPG 287
+ +A + + +++ + + + SS SSSD E ++
Sbjct: 1339 PEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHA 1398
Query: 288 PYSSVPPPSAPPPKKS 303
PPP PPP ++
Sbjct: 1399 RRRRPPPPPPPPPPRA 1414
Score = 35.4 bits (80), Expect = 0.18
Identities = 62/327 (18%), Positives = 108/327 (33%), Gaps = 50/327 (15%)
Query: 291 SVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATT 350
S P + P K+L EK Q ++ ++++ SS + P
Sbjct: 187 SYTPQTVPTGGKALS--------EKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPG 238
Query: 351 KPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTT----KSPAVKPAAAP 406
P + SS D+ SS P GT S + S + P
Sbjct: 239 NGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKP 298
Query: 407 KQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGS 466
++ Q +R+ S+SS ++S+ + ATT A++ A+ S S
Sbjct: 299 RRSENSYQDAFSRRHFSASSASTTASTA------IAATTAATASSSASSS---------S 343
Query: 467 RDSSSDSDSSSSEEEEEKTS-------------KSAVKKKPQKVAGGAAPSKPASAKKGK 513
SSS S SSSS + + + P++ P P + +
Sbjct: 344 LSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAE 403
Query: 514 ----AESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEE 569
+ +S +++ + +P P+ P+ G G + E EE
Sbjct: 404 RFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGG------GGGGGGPSPEREEVR 457
Query: 570 KKKAAVVVSKSGSLKKRKQNEAAKEAE 596
++SGS NE+ A+
Sbjct: 458 TSPRPASPARSGSPAPETTNESVPFAQ 484
>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
homolog 2 [Homo sapiens]
Length = 1210
Score = 100 bits (250), Expect = 4e-21
Identities = 136/582 (23%), Positives = 229/582 (39%), Gaps = 110/582 (18%)
Query: 85 SDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQ 144
SDSEDS + E+ P +A P+ LP A+A +S S+ SE +SD D D + +
Sbjct: 430 SDSEDS--DSEQTPEKPPSSSAPPSAPQSLPEPVASAHSS-SAESESTSDSDSSSDSESE 486
Query: 145 PVQKGVKPQAKAAKAPPKKAKSSDSDSDS-----SSEDEPPKNQKPKITP-VTVKAQTKA 198
+ SSDS+ + + E EPP K ++ +T +Q A
Sbjct: 487 -------------------SSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAA 527
Query: 199 PPKPARAAP---KIANGKAASSSSSSSSSSSSDDSEEEKAAATPK--------------- 240
PP+ R+ + K +S S++S S S D + ++ P+
Sbjct: 528 PPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQK 587
Query: 241 ----KTVPKKQVVA----KAPVKAATTPTRKSSSSED--------SSSDEEEEQKKPMKN 284
+ P++Q V K PVKA+ ++S + S D+ + K +K
Sbjct: 588 SPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKT 647
Query: 285 KPGP---YSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPT 341
K P S+ P P+ PP + KK + P S S E + E++ P
Sbjct: 648 KGRPRAAASNEPKPAVPPSSE-------KKKHKSSLPAPSKALSGPEPAKDNVEDRTPEH 700
Query: 342 KAVVSKATTKPPPAKKAAESSSDSSDS----DSSEDDEAPSKPAGTTKNSSNKPAVTTKS 397
A+V ++ PP + +S + + S D P T S + +S
Sbjct: 701 FALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQS 760
Query: 398 PAVKPA----AAPKQPVGGGQKLLTRKADSS--------SSEEESSSSEEEKTKKMVATT 445
VK + QP G G + RKA+ SSE+ SS S + KK
Sbjct: 761 LMVKITLDLLSRIPQPPGKGSR--QRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEA 818
Query: 446 KPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSE--EEEEKTSKSAVKKKPQKVAGGAAP 503
+ K + L + Q S SSS +SS ++ ++SK + P + P
Sbjct: 819 ERDCDNK-KIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKP 877
Query: 504 SKPASAKK-----------GKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPK------A 546
+KPA + K+ SS S+ DSS ++ +++GKGS K A
Sbjct: 878 AKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTA 937
Query: 547 NGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQ 588
N + NG + + + +K++A + + ++ +K++ +
Sbjct: 938 NPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAE 979
Score = 84.0 bits (206), Expect = 4e-16
Identities = 148/654 (22%), Positives = 239/654 (36%), Gaps = 103/654 (15%)
Query: 75 AKKAKKKASSSDSEDSSEEE----EEVQGPPAKKAAVPAKRVGLP----PGKAAAKASES 126
AK K K S E + E EE+ P + P P K +S
Sbjct: 333 AKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDS 392
Query: 127 SSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPK 186
+ + + D + + + + + + S DSDS+ + E +PP + P
Sbjct: 393 QHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPE-KPPSSSAPP 451
Query: 187 ITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSS-------SSSSSDDSEEEKAAATP 239
P ++ P+P +A + A S S+S S S SSS DSEE + TP
Sbjct: 452 SAPQSL-------PEPVASAH---SSSAESESTSDSDSSSDSESESSSSDSEENEPLETP 501
Query: 240 -----KKTVPKKQV---VAKAPVKAA-------TTPTRK---SSSSEDSSSDEEEEQKKP 281
T K Q+ + K AA T P R+ S S DS++ +E + K
Sbjct: 502 APEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKD 561
Query: 282 MKNKPGPYSSVPPPSA----------------PPPKKSLGTQPPKKAVEKQQPVESSEDS 325
K + PP A PP ++++GT+ PKK V+ S
Sbjct: 562 PPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSL 621
Query: 326 SDE----------SDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDE 375
E D +S+++ K TK A + P K A SS+ SS
Sbjct: 622 QGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEP--KPAVPPSSEKKKHKSSL--P 677
Query: 376 APSKP-AGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSE 434
APSK +G N T + A+ P + P G T + +E S +
Sbjct: 678 APSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKD 737
Query: 435 -------EEKTKKMVATTKPKATAKAALSLP-AKQAPQ----GSRDSSSD------SDSS 476
+ K + T P + ++L + PQ GSR ++
Sbjct: 738 RLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKH 797
Query: 477 SSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSS-DDSSEEEEEKLKG 535
SSE+ +S KK+ + K K+ K++SS+SSSS +SS+ + +
Sbjct: 798 SSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSS 857
Query: 536 KGSPRPQAPKANGTSALTAQNGKAAKNSEEE-----EEEKKKAAVVVS--KSGSLKKRKQ 588
+ S + P +S+ A K S E ++ K A+ S K S+ K+++
Sbjct: 858 QSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRR 917
Query: 589 NEAAKEAETPQAKKIKLQTPNTF--PKRKKGEKRASSPFRRVREEEIEVDSRVA 640
E + + K T N F P G + P + +++ ++ R A
Sbjct: 918 VEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREA 971
Score = 83.2 bits (204), Expect = 8e-16
Identities = 106/459 (23%), Positives = 186/459 (40%), Gaps = 70/459 (15%)
Query: 163 KAKSSDSDSDSSSEDEPPKNQKPKI----TPVTVKAQTKAPPKPARAAPKIANGKAASSS 218
K S ++S + PK+ K+ TP PP P + + A
Sbjct: 229 KVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQ 288
Query: 219 SSSSSSSSSDDSEEEKAAATPKKTVPK-------KQVVAKAPVKAATTPTRKSSSS-EDS 270
++ D ++ + + K +P+ ++ K P KA T + S S E +
Sbjct: 289 KPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQT 348
Query: 271 SSDE----EEEQKKPMKNKPGPYSSVPPPSAPPPKK----SLGTQPPKKAVEKQQPVESS 322
S+E EE K+ + P P +++ PS P K + +Q + Q+ ++S
Sbjct: 349 YSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTS 408
Query: 323 EDS------------------SDESDSSSEEE-KKPP-TKAVVSKATTKPPPAKKAAESS 362
+ SD DS SE+ +KPP + A S + P P A SS
Sbjct: 409 SKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSS 468
Query: 363 SDS---SDSDSSEDDEAPSKPAGTTKNS-------SNKPAVTTK-------SPAVKPAAA 405
++S SDSDSS D E+ S + + +N +P T K + +PAA
Sbjct: 469 AESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAP 528
Query: 406 PKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQG 465
P+ P + R +S S + ++S E ++K PK+++KA + P +AP
Sbjct: 529 PEGP--RSTEPPRRHPESKGSSDSATSQEHSESK----DPPPKSSSKAPRAPP--EAPHP 580
Query: 466 SRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESS-NSSSSDD 524
+ S S + ++E ++ K+P+K +A + ++ +G+ E S D
Sbjct: 581 GKRSCQKSPA----QQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRD 636
Query: 525 SSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNS 563
+ +++ K+K KG PR A + + K K+S
Sbjct: 637 QTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSS 675
Score = 60.1 bits (144), Expect = 7e-09
Identities = 110/511 (21%), Positives = 188/511 (36%), Gaps = 70/511 (13%)
Query: 73 PVAKKAKKKASS-------SDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASE 125
P ++K K K+S S E + + E+ P A VP PP + +
Sbjct: 665 PSSEKKKHKSSLPAPSKALSGPEPAKDNVED--RTPEHFALVPLTESQGPPHSGSGSRTS 722
Query: 126 SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKP 185
+D +D+ P+ + K + PP ++ D S P +
Sbjct: 723 GCRQAVVVQEDSRKDRLPLPL-RDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGS 781
Query: 186 KITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPK 245
+ KA+ K PP A K ++ K +S SSS + ++E + KK +
Sbjct: 782 RQR----KAEDKQPP----AGKKHSSEKRSSDSSSKLAKKRKGEAERD---CDNKKIRLE 830
Query: 246 KQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLG 305
K++ KS SS SSS +E + KP ++P SS PPP S
Sbjct: 831 KEI--------------KSQSSSSSSSHKESSKTKP--SRPSSQSS-KKEMLPPPPVSSS 873
Query: 306 TQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDS 365
+Q P K K+ E+ D S+S + K ++ P + + S S
Sbjct: 874 SQKPAKPALKRSRREADTCGQDPPKSASSTKSN-------HKDSSIPKQRRVEGKGSRSS 926
Query: 366 SDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSS 425
S+ S D A P + N ++KP P VK KQ L R+A
Sbjct: 927 SEHKGSSGDTANPFPVPSLPNGNSKPG----KPQVK---FDKQQA----DLHMREAKKMK 975
Query: 426 SEEESSSSEEEKTKKM-----------VATTKPKATAKAALSLPAKQAPQGSRDSSSDSD 474
+ E + K K +AT ++K+A S+ ++ S S
Sbjct: 976 QKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSF 1035
Query: 475 SSSSEEEEEKTSKSAVKKKPQKVAGGA--APSKPASAKKGKAESSNSSSSDDSSEEEEEK 532
S ++ +EK + + + Q + A K + K + + + SS ++
Sbjct: 1036 SDATAPTQEKIF-AVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPC 1094
Query: 533 LKGKGSPRPQAPKANGTSALTAQNGKAAKNS 563
+ G+P P +P + S++ +Q+ + S
Sbjct: 1095 IASTGTPSPLSPMPSPASSVGSQSSAGSVGS 1125
Score = 57.0 bits (136), Expect = 6e-08
Identities = 124/582 (21%), Positives = 190/582 (32%), Gaps = 140/582 (24%)
Query: 60 SAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKA 119
S+K P +A P + +K + Q PP ++ VG K
Sbjct: 567 SSKAPRAPPEAPHPGKRSCQKSPAQ-------------QEPPQRQT------VGTKQPKK 607
Query: 120 AAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEP 179
KAS + S S + E G+ P D +S+D+P
Sbjct: 608 PVKASARAGSRTSLQGERE---------PGLLPY---------------GSRDQTSKDKP 643
Query: 180 PKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATP 239
K + +A PKPA +S + S + S + +++ TP
Sbjct: 644 KVKTKGR-----PRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTP 698
Query: 240 KKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDE----EEEQKKPMKNKP-------GP 288
+ A P+ + P S S S + +E+ +K P P
Sbjct: 699 EH-------FALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSP 751
Query: 289 YSSVPPPSAPPPKKSLG-----TQPP------KKAVEKQQPVESSEDSSD-ESDSSSEEE 336
PPP + K +L QPP +KA +KQ P S SDSSS+
Sbjct: 752 LRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLA 811
Query: 337 KKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTK 396
KK +A K K+ SS SS S PS+P+ + P
Sbjct: 812 KKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVS 871
Query: 397 SPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALS 456
S + KPA K R+AD+ + S+S + K S
Sbjct: 872 SSSQKPAKP-------ALKRSRREADTCGQDPPKSASSTKSNHK-------------DSS 911
Query: 457 LPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKP-ASAKKGKAE 515
+P ++ +G SS SS + PS P ++K GK +
Sbjct: 912 IPKQRRVEGKGSRSSSEHKGSSGDTANPF---------------PVPSLPNGNSKPGKPQ 956
Query: 516 SSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAK-------------N 562
D E +K+K K +T + GKA K
Sbjct: 957 VKFDKQQADLHMREAKKMKQK------------AELMTDRVGKAFKYLEAVLSFIECGIA 1004
Query: 563 SEEEEEEKKKAAVVVSKSGSLKKRKQN-EAAKEAETPQAKKI 603
+E E + K A V S++ L K + ++ +A P +KI
Sbjct: 1005 TESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKI 1046
Score = 53.1 bits (126), Expect = 8e-07
Identities = 94/476 (19%), Positives = 160/476 (33%), Gaps = 56/476 (11%)
Query: 180 PKNQKPKITPV-TVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAAT 238
PK +P+ P+ ++ A++ PP + + + SS D + A+
Sbjct: 133 PKMAQPRTEPMPSLHAKSCGPPD----SQHLTQDRLGQEGFGSSHHKKGDRRADGDHCAS 188
Query: 239 PKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAP 298
+ P++++ + + P S++ + + K + S
Sbjct: 189 VTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKV--------HGSSNNSKGY 240
Query: 299 PPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKA 358
P KS PK K E+ +DS + PP+ S A + P A
Sbjct: 241 CPAKS-----PKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVR 295
Query: 359 AESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLT 418
D + S+S E KP K PA K P
Sbjct: 296 PMDGQDQAPSESPE-----LKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMP--------- 341
Query: 419 RKADSSSSEEESSSSE----EEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSD 474
S S E++ S+E EE K+M + P TA + P+ P + DS
Sbjct: 342 -----SQSVEQTYSNEVHCVEEILKEMTHSWPPPLTA---IHTPSTAEPSKFPFPTKDSQ 393
Query: 475 SSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLK 534
SS + +K ++ K G ++ + + S S+DS E+ +
Sbjct: 394 HVSSVTQNQKQYDTSSKTHSNSQQGTSSMLE---------DDLQLSDSEDSDSEQTPEKP 444
Query: 535 GKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKE 594
S P AP++ +A + A S + + + S S S + A E
Sbjct: 445 PSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPE 504
Query: 595 AETPQAKKIKLQ---TPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAK 647
E P K +L T + P R++ P RR E + DS + ++K
Sbjct: 505 PEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESK 560
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 97.8 bits (242), Expect = 3e-20
Identities = 116/545 (21%), Positives = 203/545 (37%), Gaps = 59/545 (10%)
Query: 64 PERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKA 123
P R ++ PV ++ + AS S S SS + PP K P KR PP K +
Sbjct: 335 PPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRS-RSPPKK----PPKRTSSPPRKTRRLS 389
Query: 124 SESSSSEES------SDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSED 177
+S + + P Q +++ + +P + + + +
Sbjct: 390 PSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRE 449
Query: 178 EPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAA 237
P KP+ ++ + K A + + + SSS S SS SE+E+
Sbjct: 450 SPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDER--- 506
Query: 238 TPKKTVPKKQVVAK----APVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVP 293
PK++ K V + +P ++A+ RK P + S P
Sbjct: 507 -PKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAP 565
Query: 294 PP-----SAPPPKKSLGTQPPKKAVEKQQ----PVESSEDSSDESDSSSEEEKKPPTKAV 344
PP PPP++ + PP++ + P++ S + PP +
Sbjct: 566 PPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKR-- 623
Query: 345 VSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSS-NKPAVTTKSPAV--- 400
+A+ PPP ++ + S S +PS + K SS ++ +SP
Sbjct: 624 --RASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKR 681
Query: 401 -KPAAAPKQP-VGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLP 458
P+ P+ P + R A SS +S S +++ T +PK KAA P
Sbjct: 682 HSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAA--SP 739
Query: 459 AKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSN 518
+ Q+ + R SSS S S S E +K + Q + +P+ P KK K+ + +
Sbjct: 740 SPQSVR--RVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVP--VKKAKSPTPS 795
Query: 519 SSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVS 578
S +S +E K K K + K K ++ ++ KK+ AV +
Sbjct: 796 PSPPRNSDQEGGGKKKKKKKDKKH---------------KKDKKHKKHKKHKKEKAVAAA 840
Query: 579 KSGSL 583
+ ++
Sbjct: 841 AAAAV 845
Score = 89.4 bits (220), Expect = 1e-17
Identities = 110/491 (22%), Positives = 189/491 (38%), Gaps = 77/491 (15%)
Query: 60 SAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKA 119
S KV + K G +++ A + SE EE+ G A +V +R +
Sbjct: 436 SGKVTKHK----GTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRR------QY 485
Query: 120 AAKASESSSSEESSDDDDEEDQKKQPVQKGV-------KPQAKAAKAPPKKAKSSDSDSD 172
+ +SSS SS ++E K+ V+ G P A+ +P K+ K +
Sbjct: 486 RRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGR 545
Query: 173 SSSEDEPP---KNQKPKITPVTVKAQTKAPP---------------KPARAAPKIANGKA 214
PP + + P P + +T PP P R +P I +
Sbjct: 546 RRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYS 605
Query: 215 ASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSS--- 271
S ++S + + + P PK++V P K ++P K S SS
Sbjct: 606 PSPPPKRRTASPPPPPKRRASPSPP----PKRRVSHSPPPKQRSSPVTKRRSPSLSSKHR 661
Query: 272 -----SDEEEEQKKPMKNK---PGPYSSVPPPSA-PPPKKSLGTQPPKKAVEKQQPVESS 322
S E + P NK P P P S+ PPP + + P++ +Q P S+
Sbjct: 662 KGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQR---RQSPSPST 718
Query: 323 EDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDS-SDSDSSEDDEAPSKPA 381
S + P K + A+ P ++ + S S S S +++ AP P
Sbjct: 719 RPIRRVS-------RTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPV 771
Query: 382 GTTKNSSN-KPAVTTKSPAVKPAAAPKQP-----VGGGQKLLTRKADSSSSEEESSSSEE 435
+ S+N PAV K A P +P P GGG+K +K +++ ++
Sbjct: 772 QSQSPSTNWSPAVPVKK-AKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKK 830
Query: 436 EKTKKMV-----ATTKPKATAKAALSLPAKQ---APQGSRDSSSDSDSSSSEEEEEKTSK 487
K +K V A P A A A +L ++ AP+ +++ S+++ + + E+ K
Sbjct: 831 HKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVAAPEPKKETESEAEDNLDDLEKHLREK 890
Query: 488 SAVKKKPQKVA 498
+ + +V+
Sbjct: 891 ALRSMRKAQVS 901
Score = 87.0 bits (214), Expect = 5e-17
Identities = 103/448 (22%), Positives = 178/448 (39%), Gaps = 53/448 (11%)
Query: 127 SSSEESSDDDDEEDQK-----KQPVQKGVKPQAKAAKAPPKKAKSSD-----SDSDSSSE 176
+S ++ +D D+ D++ ++ ++ P+ + +++P + +SS S S S
Sbjct: 142 ASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSP 201
Query: 177 DEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSS-------------SSSS 223
K++ P P K +T P+P+ + + +A S+S S
Sbjct: 202 RHRTKSRSPSPAP-EKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPS 260
Query: 224 SSSSDDSEEEKAAATPK-KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPM 282
+ E+EK P+ ++ K + ++ + T P R+ S S S ++
Sbjct: 261 PEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYS---PRRRPSP 317
Query: 283 KNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTK 342
+ +P P PP PPP + ++ P + + S SS S S KKPP
Sbjct: 318 RRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPP-- 375
Query: 343 AVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKP 402
K T+ PP +K S +S P+ P T++S P + ++ +
Sbjct: 376 ----KRTSSPP--RKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPT-PQQSNRTRKSRV 428
Query: 403 AAAPKQPVGGGQKLL-TRKADSSS-----SEEESSSSEEEKTKKMVATTKPKATAKAALS 456
+ +P + G K T K +S S + E S SEE+K KM A +
Sbjct: 429 SVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQ-------- 480
Query: 457 LPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAES 516
+Q + ++ SSSDS SSSS E+E+ +S VK +PS+ AS K +
Sbjct: 481 -QRRQYRRQNQQSSSDSGSSSS-SEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQK 538
Query: 517 SNSSSSDDSSEEEEEKLKGKGSPRPQAP 544
S + + SP P P
Sbjct: 539 ETSPRGRRRRSPSPPPTRRRRSPSPAPP 566
Score = 81.3 bits (199), Expect = 3e-15
Identities = 121/625 (19%), Positives = 238/625 (38%), Gaps = 91/625 (14%)
Query: 61 AKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAA 120
++ P + ++ P KK+ + E S + +E P ++A + + +P +
Sbjct: 198 SRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKE----PSVQEATSTSDILKVPKPEPI 253
Query: 121 AKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAP----PKKAKSSDSDSDSSSE 176
+ E S + S + ++E + + + +++P P++ S S S S
Sbjct: 254 PEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRR 313
Query: 177 DEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAA 236
P+ ++P T + PP+ R+ + + +S+S S SSSSSS ++
Sbjct: 314 RPSPR-RRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSS----SSRSR 368
Query: 237 ATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPS 296
+ PKK P K ++P RK+ S+S +++P P ++ PP +
Sbjct: 369 SPPKK-----------PPKRTSSPPRKTRRLSPSASPPRR------RHRPSPPATPPPKT 411
Query: 297 --APPPKKSLGTQPPKKAVE---------KQQPVESSEDSSD-----ESDSSSEEEKKPP 340
+P P++S T+ + +V K + E E S + + S EE K
Sbjct: 412 RHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGG 471
Query: 341 TKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAV 400
A + ++ +SSSDS S SSED+ + + ++S +
Sbjct: 472 KMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASP 531
Query: 401 KPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAK 460
P K+ G++ R++ S S + T P + P +
Sbjct: 532 SPRKRQKETSPRGRR---RRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRR 588
Query: 461 QAPQGSRDSSS-DSDSSSSEEEEEKTS--------KSAVKKKPQKVAGGAAPSK------ 505
++P R S S S + +T+ +++ P++ + P K
Sbjct: 589 RSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPV 648
Query: 506 -----PASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAA 560
P+ + K + SS S S+ ++ + K + SPRP+AP+ + + + ++
Sbjct: 649 TKRRSPSLSSKHRKGSSPSRSTREARSPQPNK-RHSPSPRPRAPQTSSSPPPVRRGASSS 707
Query: 561 KNSEEEEEEKKKAAVVVSKSGSLKKRKQ--------------NEAAKEAETPQAKK---- 602
+ + VS++ KK K+ + + + P AKK
Sbjct: 708 PQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAP 767
Query: 603 ---IKLQTPNTFPKRKKGEKRASSP 624
++ Q+P+T K+A SP
Sbjct: 768 PSPVQSQSPSTNWSPAVPVKKAKSP 792
Score = 71.2 bits (173), Expect = 3e-12
Identities = 89/430 (20%), Positives = 168/430 (39%), Gaps = 35/430 (8%)
Query: 223 SSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPM 282
+S D +++K K++ +K+ +++P + + +S S SS E+K+
Sbjct: 142 ASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKS----RSPSPRRRSSPVRRERKRSH 197
Query: 283 KNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQP-VESSEDSSDESDSSSEEEKKPPT 341
P + PS P KK + P+ +V+ ++P V+ + +SD E P
Sbjct: 198 SRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPK 257
Query: 342 KAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTK---SP 398
+ K + K +K S S S S +PS ++ S + + + SP
Sbjct: 258 EPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSP 317
Query: 399 AVKPAAAPKQPVGG---------GQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKA 449
+P+ + P + + R+ SS+S SSSS + PK
Sbjct: 318 RRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKR 377
Query: 450 TA----KAALSLPAKQAPQGSRDSSSDSDS------SSSEEEEEKTSKSAVKKKPQKVAG 499
T+ K P+ P+ S + S + ++ +T KS V P + +G
Sbjct: 378 TSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSG 437
Query: 500 GAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKA 559
K + K+ + + SE EE+K GK + + Q+
Sbjct: 438 KVTKHK-GTEKRESPSPAPKPRKVELSESEEDK-GGKMAAADSVQQRRQYRRQNQQSSSD 495
Query: 560 AKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEK 619
+ +S E+E+ K + V K+G + +R+++ ++ A K+ K T P+ ++
Sbjct: 496 SGSSSSSEDERPKRSHV--KNGEVGRRRRHSPSRSASPSPRKRQK----ETSPRGRRRRS 549
Query: 620 RASSPFRRVR 629
+ P RR R
Sbjct: 550 PSPPPTRRRR 559
Score = 34.3 bits (77), Expect = 0.40
Identities = 21/70 (30%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 564 EEEEEEKKKAAVVVSKSGSLKKR---KQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKR 620
E ++EE K+ + K S+KK+ K +E E+ + K+ + ++P R +R
Sbjct: 125 ELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRR 184
Query: 621 ASSPFRRVRE 630
SSP RR R+
Sbjct: 185 RSSPVRRERK 194
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 95.5 bits (236), Expect = 1e-19
Identities = 131/587 (22%), Positives = 223/587 (37%), Gaps = 71/587 (12%)
Query: 83 SSSDSEDSSEEEE----EVQGPPAKKAAV---PAKRVGLPPGKAAAKAS--ESSSSEESS 133
SS D ED +E+ E+ PP +K + ++ P K K + E +E
Sbjct: 115 SSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKV 174
Query: 134 DDDDEEDQK---KQPVQKGVKPQAKAAKAPPKKAKSSD-SDSDSSSEDEPPKNQKPKITP 189
+ ++ ++K K+ ++K KP+ K KKAK+++ S+ + E + K +K K T
Sbjct: 175 REKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTA 234
Query: 190 VTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVV 249
VK K P KP K KAA S + + K +
Sbjct: 235 AKVKEVQKTPSKPKEKEDK---EKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIP 291
Query: 250 AKAPVKAATTPTRKSSSSEDSSSDEEEEQKK-PMKNKPGPYSSVPPPSAPPPKKSLGTQP 308
P + A+ PT S + E+ ++++ +KK + K + S + +
Sbjct: 292 PPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKE 351
Query: 309 PKKAVE-KQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPP--------PAKKAA 359
P KA E KQ V+ + ++ + D E+ KK A V + K PAK
Sbjct: 352 PGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPK 411
Query: 360 ESSSDSSDSDSSEDDE--------------APSKPAGTTKNSSNKPAVTTKSPAVKPAAA 405
+ S SD E P K T + + KS
Sbjct: 412 KEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILK 471
Query: 406 PKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQG 465
K+P+ G ++ K +S E+E + ++EK K KPK L K+ +
Sbjct: 472 DKEPIKGKEE----KVPASLKEKEPETKKDEKMSKAGKEVKPKPP-----QLQGKKEEKP 522
Query: 466 SRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDS 525
++ + SE+ + KP+K P + K+ KA + ++
Sbjct: 523 EPQIKKEAKPAISEKVQIHKQDIV---KPEKTVSHGKPEEKV-LKQVKAVTIEKTAKPKP 578
Query: 526 SEEEEEKLKGKGSPRPQAPKAN--GTSALTAQNGKAAKNSEEEEEEKKKAAV-------V 576
+++ E + + S + PK GTS +T K K E+E K+KA + V
Sbjct: 579 TKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKK--KTEISEKESKEKADMKHLREEKV 636
Query: 577 VSKSGSLKKRKQNEAAKEA-------ETPQAKKIKLQTPNTFPKRKK 616
++ SL+ +A K A + P +KK K T + P ++K
Sbjct: 637 STRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQK 683
Score = 73.2 bits (178), Expect = 8e-13
Identities = 95/425 (22%), Positives = 157/425 (36%), Gaps = 81/425 (19%)
Query: 76 KKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKA--------------AA 121
KKA+KK +S E +E+E+++ K+ A+ ++ PGKA AA
Sbjct: 317 KKAEKKVTS---ETKKKEKEDIKKKSEKETAIDVEKK--EPGKASETKQGTVKIAAQAAA 371
Query: 122 KASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPK 181
K E + + E +Q K Q+ + + AK+ PKK S SD ++ E
Sbjct: 372 KKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKS-PKKEHSVPSDKQVKAKTE--- 427
Query: 182 NQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSD----DSEEEKAAA 237
K +I V++K P K K + S +SS D +EEK A
Sbjct: 428 RAKEEIGAVSIK--KAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPA 485
Query: 238 TPKKTVP---KKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPP 294
+ K+ P K + ++KA + P + E+ + +++ KP ++
Sbjct: 486 SLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISE--------- 536
Query: 295 PSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPP 354
K + KQ V+ + S EE+ KAV + T KP P
Sbjct: 537 ---------------KVQIHKQDIVKPEK---TVSHGKPEEKVLKQVKAVTIEKTAKPKP 578
Query: 355 AKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQ 414
KKA + + + P + T++ K ++ K
Sbjct: 579 TKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKES---------------- 622
Query: 415 KLLTRKADSSSSEEESSSSEEEKTK--KMVATTKPKATAKAALSLPA-KQAPQGSRDSSS 471
KAD EE S+ +E + + KP +K +PA K+A +G+ D S
Sbjct: 623 ---KEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSP 679
Query: 472 DSDSS 476
S
Sbjct: 680 TKQKS 684
Score = 59.3 bits (142), Expect = 1e-08
Identities = 78/357 (21%), Positives = 133/357 (37%), Gaps = 30/357 (8%)
Query: 332 SSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKP 391
SSE+E+ K PP +K E D ++ + + +K K +
Sbjct: 115 SSEDEEDDDGDEDTDKGEIDEPPLRKK-EIHKDKTEKQEKPERKIQTKVTHKEKEKGKEK 173
Query: 392 AVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATA 451
+ P K A K+ + +K T+ + +++ EEKTKK V K +
Sbjct: 174 VREKEKPEKK--ATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVK 231
Query: 452 KAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQ-----KVAGGAAPSKP 506
+ A + Q D + ++ + E+K + + + G +P+ P
Sbjct: 232 QTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIP 291
Query: 507 ASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEE 566
+A S + +S E+E EK K + + K K+ K + +
Sbjct: 292 PPLPTEQA-SRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDI----KKKSEKETAID 346
Query: 567 EEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKR------ 620
E+K+ +K G++K Q A K+ + +KK K PK KK EK+
Sbjct: 347 VEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEP 406
Query: 621 ASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKK 677
A SP +E + D +V + AK A + K GK + EKT K
Sbjct: 407 AKSP---KKEHSVPSDKQVKAKTERAKEEIG------AVSIKKAVPGK--KEEKTTK 452
Score = 56.2 bits (134), Expect = 1e-07
Identities = 66/310 (21%), Positives = 117/310 (37%), Gaps = 29/310 (9%)
Query: 75 AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSE--ES 132
+KK KK A + +E++E PAK P K +P K +E + E
Sbjct: 380 SKKTKKPAEVEQPKGKKQEKKEKHVEPAKS---PKKEHSVPSDKQVKAKTERAKEEIGAV 436
Query: 133 SDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTV 192
S +K++ K V+ + + K+ + D + E++ P + K K
Sbjct: 437 SIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEK------ 490
Query: 193 KAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKA 252
+ +TK K ++A ++ K +E K A + K + K+ +V
Sbjct: 491 EPETKKDEKMSKAGKEV-KPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPE 549
Query: 253 PVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKS-LGTQPPKK 311
+ P K + + E+ + KP K P PK + GT +
Sbjct: 550 KTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTE 609
Query: 312 AVEKQQPVESSEDSSDESDSSSEEEKKPPTK---------------AVVSKATTKPPPAK 356
+ +K+ + S ++S +++D E+K T+ A VSK P +K
Sbjct: 610 SGKKKTEI-SEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASK 668
Query: 357 KAAESSSDSS 366
KA E + D S
Sbjct: 669 KAKEGTEDVS 678
>gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
Length = 671
Score = 94.7 bits (234), Expect = 3e-19
Identities = 135/588 (22%), Positives = 211/588 (35%), Gaps = 119/588 (20%)
Query: 73 PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEES 132
P K K + + +E E+Q P + P P + ++A E++ ++ S
Sbjct: 60 PYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPP-----PVSSSDSEAPEANPADGS 114
Query: 133 SDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTV 192
D+D+ED +GV SDSDSD SS++ K + P +
Sbjct: 115 DADEDDED-------RGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVS 167
Query: 193 KAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVP----KKQV 248
K KA +A+ + + + SSS S +S D + E+KAA + P KK+
Sbjct: 168 KRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKK 227
Query: 249 VAKA-------------PVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPP 295
A P A + SSSS SSSD + KKP + + +P P
Sbjct: 228 APSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKP 287
Query: 296 SAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPA 355
PK +PP + SS+ SDE D SE +++ + +A +
Sbjct: 288 RGRKPKPE---RPPSSS--------SSDSDSDEVDRISEWKRRDEARRRELEARRRREQE 336
Query: 356 KK----------------------AAESSSDSSDSDSSEDDEAPSKPAG----------- 382
++ AE S S D +D+ P K G
Sbjct: 337 EELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSS 396
Query: 383 -----------TTKNSSNKPAVTTKSPAVKPA-------AAPKQPVGGGQKLLTRKADSS 424
K S+ KP ++ PA KP KQ + TRK
Sbjct: 397 SDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEG 456
Query: 425 SS-----EEESSSSEEEKTKKM---------VATTKPKATAKAALSLPAKQAPQGSRDSS 470
S E++ S EEK +K+ V + K A L Q +
Sbjct: 457 FSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKN 516
Query: 471 SDSDSSSSEEEEEKTSKSAVKKKPQ-------KVAG----GAAPSKPASAKKGKAESSNS 519
+D ++ + K +K ++K + +V G A +K KAE +
Sbjct: 517 TDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLA 576
Query: 520 SSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEE 567
E +EK + K S AP NG + T+Q G++A++ E EE
Sbjct: 577 GEELAGEEAPQEKAEDKPSTDLSAP-VNGEA--TSQKGESAEDKEHEE 621
Score = 89.4 bits (220), Expect = 1e-17
Identities = 119/534 (22%), Positives = 204/534 (38%), Gaps = 70/534 (13%)
Query: 66 RKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASE 125
RK ++ A + + +S+S SE+ + P KKAAV A R G G+ KA
Sbjct: 171 RKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPS 230
Query: 126 SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKP 185
+S S+ +D D + + P A A A + SS SDSD S + +PP+ +KP
Sbjct: 231 ASDSDSKADSDGAKPE----------PVAMARSASSSSSSSSSSDSDVSVK-KPPRGRKP 279
Query: 186 KITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSS-------SSSDDSEEEKAAAT 238
P+ PKP PK ++SSS S S D++ + A
Sbjct: 280 AEKPL---------PKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEAR 330
Query: 239 PKKTVPKKQVVAKAPVKAATTPTRKSS-------SSEDSSSDEEEEQKKPMKNKPGPYSS 291
++ ++ + K R+ + S SS DE E +P+K +
Sbjct: 331 RRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRG 390
Query: 292 VPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTK 351
PPS+ P+ +E++ + + S ++ + + +K K K
Sbjct: 391 RGPPSS-------SDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAK 443
Query: 352 PPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTK-NSSNKPAVTTKSPAVKPAAAPKQPV 410
P ++ + S S E + PS K +S K A+ SP VK + +
Sbjct: 444 PVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEEL 503
Query: 411 GGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSS 470
G Q +S +K +VAT K KA + K A +R S
Sbjct: 504 GTLQ---------------VTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKS 548
Query: 471 SDSDSSSSEEEEEKTSKSAVKKKP-------QKVAGGAAPSKPASAKKGKAESS--NSSS 521
E +K +K+ ++K+ +++AG AP + A K S+ N +
Sbjct: 549 --RVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEA 606
Query: 522 SDDSSEEEEEKLKGKGSPRPQAPKANGTSAL--TAQNGKAAKNSEEEEEEKKKA 573
+ E E+K +G + P+ + L + + G + +E+++A
Sbjct: 607 TSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERA 660
Score = 51.6 bits (122), Expect = 2e-06
Identities = 71/318 (22%), Positives = 132/318 (41%), Gaps = 39/318 (12%)
Query: 353 PPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGG 412
P A +A SSDS++ E + A A AVT AV AA +
Sbjct: 88 PHASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVT----AVTATAASDR---- 139
Query: 413 GQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSD 472
++DS S + +S + KT + + +A ++ A +P S +
Sbjct: 140 ------MESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSP-----SEEE 188
Query: 473 SDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEK 532
+ SSS E EKTS P+K A AP + + K ++ ++S SD ++ + K
Sbjct: 189 NSESSS--ESEKTSDQDF--TPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAK 244
Query: 533 LKGKGSPRPQAPKANGTSALTAQNGKAAKNS-EEEEEEKKKAAVVVSKSGSLK---KRKQ 588
P P A + +S+ ++ + + S ++ +K A + K K +R
Sbjct: 245 ------PEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPP 298
Query: 589 NEAAKEAETPQAKKIKLQTPNTFPKRKKGEKR----ASSPFRRVREEEIEVDSRVADNS- 643
+ ++ ++++ + +I +R++ E R RR+RE+E E R + +
Sbjct: 299 SSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERAD 358
Query: 644 -FDAKRGAAGDWGERANQ 660
+A+RG+ G G+ +
Sbjct: 359 RGEAERGSGGSSGDELRE 376
>gi|14249158 hepatoma-derived growth factor-related protein 2
isoform 2 [Homo sapiens]
Length = 670
Score = 94.7 bits (234), Expect = 3e-19
Identities = 135/588 (22%), Positives = 211/588 (35%), Gaps = 119/588 (20%)
Query: 73 PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEES 132
P K K + + +E E+Q P + P P + ++A E++ ++ S
Sbjct: 60 PYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPP-----PVSSSDSEAPEANPADGS 114
Query: 133 SDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTV 192
D+D+ED +GV SDSDSD SS++ K + P +
Sbjct: 115 DADEDDED-------RGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVS 167
Query: 193 KAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVP----KKQV 248
K KA +A+ + + + SSS S +S D + E+KAA + P KK+
Sbjct: 168 KRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKK 227
Query: 249 VAKA-------------PVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPP 295
A P A + SSSS SSSD + KKP + + +P P
Sbjct: 228 APSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKP 287
Query: 296 SAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPA 355
PK +PP + SS+ SDE D SE +++ + +A +
Sbjct: 288 RGRKPKPE---RPPSSS--------SSDSDSDEVDRISEWKRRDEARRRELEARRRREQE 336
Query: 356 KK----------------------AAESSSDSSDSDSSEDDEAPSKPAG----------- 382
++ AE S S D +D+ P K G
Sbjct: 337 EELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSS 396
Query: 383 -----------TTKNSSNKPAVTTKSPAVKPA-------AAPKQPVGGGQKLLTRKADSS 424
K S+ KP ++ PA KP KQ + TRK
Sbjct: 397 SDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEG 456
Query: 425 SS-----EEESSSSEEEKTKKM---------VATTKPKATAKAALSLPAKQAPQGSRDSS 470
S E++ S EEK +K+ V + K A L Q +
Sbjct: 457 FSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKN 516
Query: 471 SDSDSSSSEEEEEKTSKSAVKKKPQ-------KVAG----GAAPSKPASAKKGKAESSNS 519
+D ++ + K +K ++K + +V G A +K KAE +
Sbjct: 517 TDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLA 576
Query: 520 SSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEE 567
E +EK + K S AP NG + T+Q G++A++ E EE
Sbjct: 577 GEELAGEEAPQEKAEDKPSTDLSAP-VNGEA--TSQKGESAEDKEHEE 621
Score = 89.0 bits (219), Expect = 1e-17
Identities = 119/533 (22%), Positives = 203/533 (38%), Gaps = 69/533 (12%)
Query: 66 RKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASE 125
RK ++ A + + +S+S SE+ + P KKAAV A R G G+ KA
Sbjct: 171 RKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPS 230
Query: 126 SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKP 185
+S S+ +D D + + P A A A + SS SDSD S + +PP+ +KP
Sbjct: 231 ASDSDSKADSDGAKPE----------PVAMARSASSSSSSSSSSDSDVSVK-KPPRGRKP 279
Query: 186 KITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSS-------SSSDDSEEEKAAAT 238
P+ PKP PK ++SSS S S D++ + A
Sbjct: 280 AEKPL---------PKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEAR 330
Query: 239 PKKTVPKKQVVAKAPVKAATTPTRKSS-------SSEDSSSDEEEEQKKPMKNKPGPYSS 291
++ ++ + K R+ + S SS DE E +P+K +
Sbjct: 331 RRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRG 390
Query: 292 VPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTK 351
PPS+ P+ +E++ + + S ++ + + +K K K
Sbjct: 391 RGPPSS-------SDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAK 443
Query: 352 PPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTK-NSSNKPAVTTKSPAVKPAAAPKQPV 410
P ++ + S S E + PS K +S K A+ SP VK + +
Sbjct: 444 PVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEEL 503
Query: 411 GGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSS 470
G Q +S +K +VAT K KA + K A +R S
Sbjct: 504 GTLQ---------------VTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKS 548
Query: 471 SDSDSSSSEEEEEKTSKSAVKKKP-------QKVAGGAAPSKPASAKKGKAESS--NSSS 521
E +K +K+ ++K+ +++AG AP + A K S+ N +
Sbjct: 549 --RVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEA 606
Query: 522 SDDSSEEEEEKLKGKGSPRPQAPKANGTSAL-TAQNGKAAKNSEEEEEEKKKA 573
+ E E+K +G + P+ + L + G + +E+++A
Sbjct: 607 TSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDVREGPDLDRPGSDRQERERA 659
Score = 51.6 bits (122), Expect = 2e-06
Identities = 71/318 (22%), Positives = 132/318 (41%), Gaps = 39/318 (12%)
Query: 353 PPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGG 412
P A +A SSDS++ E + A A AVT AV AA +
Sbjct: 88 PHASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVT----AVTATAASDR---- 139
Query: 413 GQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSD 472
++DS S + +S + KT + + +A ++ A +P S +
Sbjct: 140 ------MESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSP-----SEEE 188
Query: 473 SDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEK 532
+ SSS E EKTS P+K A AP + + K ++ ++S SD ++ + K
Sbjct: 189 NSESSS--ESEKTSDQDF--TPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAK 244
Query: 533 LKGKGSPRPQAPKANGTSALTAQNGKAAKNS-EEEEEEKKKAAVVVSKSGSLK---KRKQ 588
P P A + +S+ ++ + + S ++ +K A + K K +R
Sbjct: 245 ------PEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPP 298
Query: 589 NEAAKEAETPQAKKIKLQTPNTFPKRKKGEKR----ASSPFRRVREEEIEVDSRVADNS- 643
+ ++ ++++ + +I +R++ E R RR+RE+E E R + +
Sbjct: 299 SSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERAD 358
Query: 644 -FDAKRGAAGDWGERANQ 660
+A+RG+ G G+ +
Sbjct: 359 RGEAERGSGGSSGDELRE 376
>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
Length = 3664
Score = 94.0 bits (232), Expect = 4e-19
Identities = 142/651 (21%), Positives = 238/651 (36%), Gaps = 72/651 (11%)
Query: 79 KKKASSSDSE--------DSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSE 130
KKK +DSE D EEE+E Q A + + + + + E
Sbjct: 1496 KKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFE-----QDSKRLQHLERKE 1550
Query: 131 ESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPV 190
E SD KQ +G + + P S + + E K+QKPK V
Sbjct: 1551 EDSDFISGRIYGKQ-TSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPK--EV 1607
Query: 191 TVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAA---ATPKKTVPKKQ 247
+ T+ PK +AP+ + + + S S + E +A T KTV
Sbjct: 1608 EKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPL 1667
Query: 248 VVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQ 307
V + V+ AT +SE + + E+ ++ + P A + S G Q
Sbjct: 1668 VTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQ 1727
Query: 308 PPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSD 367
PP ++ + P + S ES+ E + P K+ P + ++++D+
Sbjct: 1728 PP--YLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEP 1785
Query: 368 SDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGG-----QKLLTRKAD 422
+ + + AP +++ P V K + K PV +K +TRK++
Sbjct: 1786 DANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSE 1845
Query: 423 ---------SSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAP---------Q 464
S+S E+ E K + T + A L P P +
Sbjct: 1846 RIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVR 1905
Query: 465 GSRDSSSDSDSSSSEE---EEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSS 521
+ D ++ S + E+ + ++ ++++ Q+ A A P+ P + K
Sbjct: 1906 SVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAA--AVPTTPRRGRPPKTRRRADEE 1963
Query: 522 SDDSSEEEEEKLK---GKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVS 578
++ ++E E LK G SPR Q A G GK KN + + + +A V
Sbjct: 1964 EENEAKEPAETLKPPEGWRSPRSQKTAAGG-----GPQGKKGKNEPKVDATRPEATTEVG 2018
Query: 579 KSGSLKKRKQNEAAKEAETPQAKK-------IKLQTPNTFP-----KRKKGEKRASSPFR 626
+K+ A E E +K P T P K+ EK + S
Sbjct: 2019 PQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRG 2078
Query: 627 RVREEEIEVDSRVADNSFDA---KRGAAGDWGERANQVLKFTKGKSFRHEK 674
R R + VD + + DA RGAA GER + V+ + KS +K
Sbjct: 2079 RSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQK 2129
Score = 61.6 bits (148), Expect = 2e-09
Identities = 131/651 (20%), Positives = 230/651 (35%), Gaps = 107/651 (16%)
Query: 61 AKVPERKLQANGPVAKK----------AKKKASSS-DSEDSSEEEEEVQGPPAKKAAVP- 108
+K ++ +AN P A+K A +KA ++ +S+ + E+ EV P A K P
Sbjct: 1760 SKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPN 1819
Query: 109 -AKRVGLPPGKAAAKASESSSSEESSDDDDEE----DQKKQPVQKGVKPQAKAAKAPPKK 163
+KR P AA E + +S D E+ + + QK ++ + +A K
Sbjct: 1820 KSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTA 1879
Query: 164 AKSSDSDSDSSSEDEP-PKNQKPKITPVTVKA---QTKAPPKPARAAPKIANGKAASSSS 219
+K+S +D + P + ++ + V + ++P K P++ +
Sbjct: 1880 SKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQ 1939
Query: 220 SSSSSSSSD------------DSEEEKAAATPKKTV--------PKKQVVAKA------- 252
+++ ++ D EEE A P +T+ P+ Q A
Sbjct: 1940 EAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKK 1999
Query: 253 ----PVKAATTPTR----------KSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAP 298
P AT P K SS E +++EE ++ K PP +AP
Sbjct: 2000 GKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAP 2059
Query: 299 PPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKA 358
P K + K+ +S + D+S S + A P A
Sbjct: 2060 VEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVD-----------AAVSPRGAAAQ 2108
Query: 359 AESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLT 418
A + S E E+P K G + + P K P + +A Q L
Sbjct: 2109 AGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQ--LA 2166
Query: 419 RKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSS 478
++ + + E + E P+ A PA QA + ++ S +
Sbjct: 2167 KQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDI 2226
Query: 479 EEEEEK-------TSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEE 531
E E +S +P A PS ++G S ++ E
Sbjct: 2227 SGEPENFPAPPPYPGESQTDLQPPAGAQALQPS-----EEGMETDEAVSGILETEAATES 2281
Query: 532 KLKGKGSPRPQA-----PKANGTSALTAQNGKAAKNSEEEE---EEKKKAAVVVSKSGSL 583
+P P A +A G S+ T+ + AK S+E E K K ++ S
Sbjct: 2282 SRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTR--SR 2339
Query: 584 KKRKQNE---AAKEAETPQAKKIKLQTPNT-------FPKRKKGEKRASSP 624
+KR N+ A E+ P++ + + ++P P+ + EK++ P
Sbjct: 2340 RKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKP 2390
Score = 60.8 bits (146), Expect = 4e-09
Identities = 106/466 (22%), Positives = 167/466 (35%), Gaps = 77/466 (16%)
Query: 92 EEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVK 151
E + ++Q PPA A+ G+ +A + E+ ++ ESS + PV
Sbjct: 2242 ESQTDLQ-PPAGAQALQPSEEGMETDEAVSGILETEAATESS---------RPPVNA--- 2288
Query: 152 PQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIAN 211
P A K+A+ + S++ S P+ + K VT+ + K K R+ K
Sbjct: 2289 PDPSAGPTDTKEARGNSSETSHSV----PEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNT 2344
Query: 212 GKAASSSSSSSSSSSSDDSEEEKAAAT------PKKTVPKKQVVA--KAPVKAATTPTRK 263
K + S S+ E AA P+ +KQ P ++ T+ K
Sbjct: 2345 NKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSK 2404
Query: 264 SSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSE 323
S+E+SS + E++ P K +SVPP PPP + +A + + S+
Sbjct: 2405 IPSTENSSQEISVEERTPTK------ASVPP-DLPPPPQPAPVDEEPQARFRVHSIIESD 2457
Query: 324 DSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGT 383
+ SD S PT V+ A PP A S P+K
Sbjct: 2458 PVTPPSDPSI----PIPTLPSVTAAKLSPPVA------------SGGIPHQSPPTKVTEW 2501
Query: 384 TKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEK----TK 439
A +T SPA+ P D+ +S+ ++SSS K K
Sbjct: 2502 ITRQEEPRAQSTPSPALPP-------------------DTKASDVDTSSSTLRKILMDPK 2542
Query: 440 KMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEK---TSKSAVKKKPQK 496
+ AT+ + A++ P AP DS EE+ T+ S ++
Sbjct: 2543 YVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVL 2602
Query: 497 VAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQ 542
VA P A K + S S D ++ L P PQ
Sbjct: 2603 VAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITL---AKPAPQ 2645
Score = 48.5 bits (114), Expect = 2e-05
Identities = 90/449 (20%), Positives = 169/449 (37%), Gaps = 45/449 (10%)
Query: 259 TPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQP 318
+P S +E SD E ++ G SS+ PP KS +E+
Sbjct: 736 SPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKS--------RLERYTK 787
Query: 319 VESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAK-KAAESSSDSSDSD-SSEDDEA 376
E ++ E E++ K V K T K K SS SS++D +E +++
Sbjct: 788 NEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQENEREQS 847
Query: 377 PSKPAGTTKNS---SNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTR------KADSSSSE 427
P KP K S ++K + + P + K++ KA +
Sbjct: 848 PEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDT 907
Query: 428 EESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSK 487
+SS+ ++ K V+ T+P + + L + P+ + SS E EK +
Sbjct: 908 VKSSALDQ---KLQVSQTEPAKSDLSKLESVRMKVPK-------EKGLSSHVEVVEKEGR 957
Query: 488 SAVKK--KPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPK 545
+K KP++ A G + +K +A + S+ +E+++ ++K K SP + +
Sbjct: 958 LKARKHLKPEQPADGVS---AVDLEKLEARKRRFADSNLKAEKQKPEVK-KSSPEMEDAR 1013
Query: 546 ANGTSALTAQNGKAAKNSEEEEEEKK-KAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIK 604
+ + E E E K + ++ +S +K + N A + + I
Sbjct: 1014 VLSKKQPDVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASIS 1073
Query: 605 L---QTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQV 661
+ P++ + + GE S V +E++ + + D G V
Sbjct: 1074 VGSGSRPSSDLQARLGELAGES----VENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDV 1129
Query: 662 LKFTKGKSFRHEKTKKKRGSYRGGSISVQ 690
K S R E ++K G + S++ +
Sbjct: 1130 RK--NYCSLRDETPERKSGQEKSHSVNTE 1156
Score = 38.5 bits (88), Expect = 0.021
Identities = 34/123 (27%), Positives = 55/123 (44%), Gaps = 16/123 (13%)
Query: 158 KAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPP-----KPARAAPKIANG 212
+ P + + S S S SS+ +NQ P+ T++P + ++ I++
Sbjct: 231 RRPERNYQHSRSRSPHSSQS---RNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSS 287
Query: 213 KAASSSSSSSSSSSSDDS--EEEKAAATPKKT------VPKKQVVAKAPVKAATTPTRKS 264
+ SS SS SSSSSSDDS ++AA P T + K + +K P R +
Sbjct: 288 SSTSSDSSDSSSSSSDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRST 347
Query: 265 SSS 267
+S
Sbjct: 348 DTS 350
Score = 37.7 bits (86), Expect = 0.036
Identities = 22/90 (24%), Positives = 40/90 (44%)
Query: 311 KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDS 370
+ V ++P + + S S SS+ + P + + P+ + S S SSDS S
Sbjct: 226 REVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSIS 285
Query: 371 SEDDEAPSKPAGTTKNSSNKPAVTTKSPAV 400
S + ++ +S + PA + +S AV
Sbjct: 286 SSSSTSSDSSDSSSSSSDDSPARSVQSAAV 315
Score = 32.7 bits (73), Expect = 1.2
Identities = 30/120 (25%), Positives = 49/120 (40%), Gaps = 8/120 (6%)
Query: 486 SKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSD---DSSEEEEEKLKGKGSPRPQ 542
S + + PQ++A A S+P + G S SSSSD SS + S
Sbjct: 247 SSQSRNQSPQRLASQA--SRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSSSSDD 304
Query: 543 APKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKK 602
+P + SA +S E++E +K + V +L R + + K+ + KK
Sbjct: 305 SPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQ---NLPVRSTDTSLKDGLFHEFKK 361
Score = 32.7 bits (73), Expect = 1.2
Identities = 129/697 (18%), Positives = 233/697 (33%), Gaps = 153/697 (21%)
Query: 42 QQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASSSDSED-----------S 90
+Q A+ S +D+ + + + L+A +K + K SS + ED S
Sbjct: 967 EQPADGVSAVDLEKLEARKRRFADSNLKAE---KQKPEVKKSSPEMEDARVLSKKQPDVS 1023
Query: 91 SEE-----EEEVQGPPAKKAAVP--AKRVGLP---------PGKAAAKASESSSSEESSD 134
S E E E + P +K + +K++ L + A S S S SSD
Sbjct: 1024 SREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRPSSD 1083
Query: 135 ------------DDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDS--SSEDEPP 180
+++E Q K+P+ KPQ K + + + + S DE P
Sbjct: 1084 LQARLGELAGESVENQEVQSKKPIPS--KPQLKQLQVLDDQGPEREDVRKNYCSLRDETP 1141
Query: 181 KNQKPKITPVTVKAQ---------TKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSE 231
+ + + +V + T++ K + + + + S S D E
Sbjct: 1142 ERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVDE 1201
Query: 232 EEKAAATPKKTVPKKQVVAKAPVKA-----------ATTPTRKSSSSEDSSSDEEEEQKK 280
E+ + + P + V +P T R SS S D E
Sbjct: 1202 YERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGGS 1261
Query: 281 PMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQP-----VESSEDSSDESDSSSEE 335
P + P +P + L + K EK P V + DSS E
Sbjct: 1262 PSVRHGSFHEDEDPIGSP---RLLSVKGSPKVDEKVLPYSNITVREESLKFNPYDSSRRE 1318
Query: 336 EKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSS-------------------EDDEA 376
+ K +S ++ + ++ D+ D S E E
Sbjct: 1319 QMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSVRDLEPGEV 1378
Query: 377 PSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEE 436
PS ++ S+ P + + + + LL + D +E SS E
Sbjct: 1379 PSDSDEDGEHKSHSPRASALYESSRLSF-----------LLRDREDKLRERDERLSSSLE 1427
Query: 437 KTK------KMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAV 490
+ K T KA + A SL SSS ++ S + + + +
Sbjct: 1428 RNKFYSFALDKTITPDTKALLERAKSL-----------SSSREENWSFLDWDSRFANFRN 1476
Query: 491 KKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTS 550
K +KV P KK K + + DD E+ +E+ + + + S
Sbjct: 1477 NKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQER---QELFASRFLHS 1533
Query: 551 ALTAQNGKAAKNSEEEEEE----------KKKAAVVVSKSGSL----------------- 583
++ Q+ K ++ E +EE+ K+ + S + S+
Sbjct: 1534 SIFEQDSKRLQHLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRM 1593
Query: 584 --KKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGE 618
K++++++ KE E + + +TP + P+ K E
Sbjct: 1594 QQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSE 1630
Score = 30.4 bits (67), Expect = 5.8
Identities = 17/54 (31%), Positives = 23/54 (42%)
Query: 299 PPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKP 352
P + G+ ++ SS SSD SDSSS P ++V S A P
Sbjct: 265 PTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSSSSDDSPARSVQSAAVPAP 318
Score = 30.0 bits (66), Expect = 7.6
Identities = 28/125 (22%), Positives = 52/125 (41%), Gaps = 9/125 (7%)
Query: 305 GTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSD 364
G +P + + S S ++S + PT++ + + + SSS
Sbjct: 230 GRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSS 289
Query: 365 S----SDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVG-GGQKLLTR 419
+ SDS SS D++P++ + S+ PA T++ + P++ G Q L R
Sbjct: 290 TSSDSSDSSSSSSDDSPAR----SVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVR 345
Query: 420 KADSS 424
D+S
Sbjct: 346 STDTS 350
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 93.6 bits (231), Expect = 6e-19
Identities = 121/543 (22%), Positives = 219/543 (40%), Gaps = 55/543 (10%)
Query: 103 KKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVK--PQAKAAKAP 160
++ A AK+ P K + ESSSS + ++ +KK ++ P+ + K+
Sbjct: 154 QRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSS 213
Query: 161 PKKAKSSDSDSDSSSEDEP-PKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSS 219
KK S+S+S P PK+++ ++++ P +R A + +A S+S
Sbjct: 214 KKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHR---STSADSAS 270
Query: 220 SSSSSSSSDDSEEEK------AAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSS-- 271
SS +S S S K A +P ++ + TT T++ SS E ++
Sbjct: 271 SSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQ 330
Query: 272 -SDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESD 330
S E++ K K K S PS P + S G +PP + S +
Sbjct: 331 PSSPYEDKDKDKKEK-----SATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPL-ATT 384
Query: 331 SSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNK 390
S+E PP++A S + PP K+ E SS S+SS P+K ++++S+
Sbjct: 385 PLSQEPVNPPSEA--SPTRDRSPP--KSPEKLPQSSSSESSPPSPQPTK---VSRHASSS 437
Query: 391 PAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKAT 450
P +SP KPA AP + + SSS ++ S K K + T +
Sbjct: 438 P----ESP--KPAPAPG----------SHREISSSPTSKNRSHGRAKRDKSHSHTPSRRM 481
Query: 451 AKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVK----KKPQKVAGGAAPSKP 506
++ AK+ SR + + S S + + S+SA + + PQ+ +P +P
Sbjct: 482 GRSRSPATAKRGRSRSR-TPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRP 540
Query: 507 ASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEE 566
++ + S S +G R + P G S A + S
Sbjct: 541 GWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRS---RSRTPARRRSRSR 597
Query: 567 EEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFR 626
++++ S++ + + R ++ + ++ ++ + P R+ G R+ +P R
Sbjct: 598 TPTRRRSR---SRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPAR 654
Query: 627 RVR 629
R R
Sbjct: 655 RGR 657
Score = 91.7 bits (226), Expect = 2e-18
Identities = 120/577 (20%), Positives = 218/577 (37%), Gaps = 64/577 (11%)
Query: 79 KKKASSSDSEDSSEEEEEVQGPPAKK----AAVPAKRVGLPPGKAAAKASESSSSEESSD 134
+K SS+ SS + V P+++ A+ P + GLP + ++ S S SS D
Sbjct: 1392 EKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLP--RTPSRRSRSGSSPGLRD 1449
Query: 135 DDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKA 194
P + + + K P+ S+ DSS E PK P T +
Sbjct: 1450 GSGT------PSRHSLSGSSPGMKDIPRTPSRGRSECDSSPE--------PKALPQTPRP 1495
Query: 195 QTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPV 254
++++P P N K + S S SS D ++ A TP + + V
Sbjct: 1496 RSRSPSSPE------LNNKCLTPQRERSGSESSVD--QKTVARTPLGQRSRSGSSQELDV 1547
Query: 255 KAATTPTRKSSSSEDSSSDEEEEQKKPM--KNKPGPYSSVPPPSAPPPKKS-LGTQPPKK 311
K + +P +S S DSS D + + + P+ +++ G V S P++S G+ P K
Sbjct: 1548 KPSASPQERSES--DSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVK 1605
Query: 312 AVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSS 371
+ P +S S S E K P + + + +K S SS ++SS
Sbjct: 1606 DKPRAAP-------RAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESS 1658
Query: 372 EDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESS 431
+ S+ A SS +P +++P P++ LTRKA S +S
Sbjct: 1659 PEHPPKSRTARRGSRSSPEPKTKSRTP-------PRRRSSRSSPELTRKARLSRRSRSAS 1711
Query: 432 SSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVK 491
SS E +++ T P+ ++S P + + SR S +SS + +
Sbjct: 1712 SSPETRSR-----TPPRHRRSPSVSSP--EPAEKSRSSRRRRSASSPRTKTTSRRGRSPS 1764
Query: 492 KKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGK-------GS---PRP 541
KP+ + + S+ + + + SS S + + + + GS R
Sbjct: 1765 PKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRS 1824
Query: 542 QAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAK 601
A + + ++ + G++ + + + + K + + TP
Sbjct: 1825 PARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLIS 1884
Query: 602 KIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSR 638
+ + ++ + R++ R S RR R V R
Sbjct: 1885 RRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRR 1921
Score = 89.0 bits (219), Expect = 1e-17
Identities = 110/502 (21%), Positives = 203/502 (40%), Gaps = 66/502 (13%)
Query: 213 KAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAAT--TPTRKSSSSEDS 270
K S+ SS SSS EKA + +++ +PV A TP+R+ SSS S
Sbjct: 1372 KEQSTRSSGHSSSELSPDAVEKAGMSSNQSI-------SSPVLDAVPRTPSRERSSSASS 1424
Query: 271 SSDEEEEQKKPMK-NKPGPYSSVPPPSAPPPKKSL-GTQPPKKAVEKQQPVESSEDSSDE 328
++ + P + ++ G + S P + SL G+ P K + + + E
Sbjct: 1425 PEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPR-----TPSRGRSE 1479
Query: 329 SDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSK-PAGTTKNS 387
DSS E + P T S++ + P K + S S+SS D + ++ P G S
Sbjct: 1480 CDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRS 1539
Query: 388 SNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKP 447
+ + VKP+A+P++ +++S SS + + + ++ + + P
Sbjct: 1540 GSSQELD-----VKPSASPQE-----------RSESDSSPDSKAKTRTPLRQRSRSGSSP 1583
Query: 448 KATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAP--SK 505
+ +K+ LS P+ SR SS S S +P+ A A P S+
Sbjct: 1584 EVDSKSRLS------PRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSR 1637
Query: 506 PASAKKGKAESSNSSSSDDSSEEE---------------EEKLKGKGSPRPQAPKANGTS 550
S+ KG+ S SSS +SS E E K K + PR ++ +++
Sbjct: 1638 SGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPEL 1697
Query: 551 ALTAQNGKAAKNSEEEEEEKKKA------AVVVSKSGSLKKRKQNEAAKEAETPQAKKIK 604
A+ + ++++ E + + + VS +K + + + A +P+ K
Sbjct: 1698 TRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTS 1757
Query: 605 LQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKF 664
+ + PK +G +R+ S RR + R + ++R ++V +
Sbjct: 1758 RRGRSPSPK-PRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQR---SRSRSRVTRR 1813
Query: 665 TKGKSFRHEKTKKKRGSYRGGS 686
+G S H ++ ++ S R S
Sbjct: 1814 RRGGSGYHSRSPARQESSRTSS 1835
Score = 77.0 bits (188), Expect = 5e-14
Identities = 122/571 (21%), Positives = 208/571 (36%), Gaps = 44/571 (7%)
Query: 1 MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKS 60
M+ AG+ + P+ L LR + +A++ A+ A A+A + + L
Sbjct: 2199 MSAAGLAARMSQVPAPVPLMSLRTAPAANLASRIPAASAAAMNLASARTPAIPTAVNLAD 2258
Query: 61 AKVPERKLQAN--GPVAKKAKKKASSSDSEDSSEEEEEVQGP--PAKKAAVPAKRVGLPP 116
++ P N P A + +D + + G PA AA+ G PP
Sbjct: 2259 SRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTPP 2318
Query: 117 GKAAAKASESSSSEESSDD--DDEEDQKKQPVQ-KGVKPQAKAAKAPPKKAKSSDSDSDS 173
A +S + +S + PV G + A A A A+ + + S +
Sbjct: 2319 TAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGA 2378
Query: 174 S-SEDEPPKNQKPKIT-----PVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSS 227
+ + P + +++ P+ +A+++ PP A + ++ + +A S SS + S
Sbjct: 2379 NLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPS-APSQSRMTSERAPSPSSRMGQAPSQ 2437
Query: 228 DDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKS---SSSEDSSSDEEEEQKKPMKN 284
S A P+ VP + A TTP S SS +++ M +
Sbjct: 2438 --SLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLS 2495
Query: 285 KPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAV 344
P P VP P S G Q P A+ QP + SS S SSS
Sbjct: 2496 VPAP--GVPHSDVGEPPASTGAQQPS-ALAALQPAKERRSSSSSSSSSSSS--------- 2543
Query: 345 VSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSK----PAGTTKNSSNKPAVTTKSPAV 400
S +++ + + SSSDS S E K P K + + +PA
Sbjct: 2544 -SSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAK 2602
Query: 401 KPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLP-- 458
+ + + + SSSS SSSS + +++ P +LP
Sbjct: 2603 RKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKP 2662
Query: 459 --AKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAES 516
K+ P G R S S S + S S V+++ + +S+++G
Sbjct: 2663 ASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERG---- 2718
Query: 517 SNSSSSDDSSEEEEEKLKGKGSPRPQAPKAN 547
S DS ++ + SPRP +++
Sbjct: 2719 SRRGQRGDSRSPSHKRRRETPSPRPMRHRSS 2749
Score = 75.9 bits (185), Expect = 1e-13
Identities = 116/600 (19%), Positives = 210/600 (35%), Gaps = 87/600 (14%)
Query: 61 AKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKR---VGLPPG 117
++ P+R+ ++ +K K + S S +S P KK+ + ++R + P
Sbjct: 715 SRTPQRRGRSGSSSERKNKSRTSQRRSRSNSS-------PEMKKSRISSRRSRSLSSPRS 767
Query: 118 KAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKA-AKAPPKKAKSSDSDSDSSSE 176
KA ++ S S SS ++ Q + Q KA ++ PP++++SS S
Sbjct: 768 KAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKS 827
Query: 177 DEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKA- 235
P + +P K ++ PP+ AN ++ + S SS D + +
Sbjct: 828 KTPSRQSHSSSSPHP-KVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTP 886
Query: 236 --------------AATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEE-EEQKK 280
++TP + P + + VKA +P ++S S S S +
Sbjct: 887 SRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTT 946
Query: 281 PMKNKP-GPYSSVP-------------------PPSAPPPKKSLGTQPPKKAVEKQQPVE 320
P +++ P S+V P PP + G+ P V+ Q P
Sbjct: 947 PRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPG 1006
Query: 321 SSEDSS-----DESDSSSEEEKKPPTKAVVSKATTKPPPAKK--AAESSSDSSDSDSSED 373
S S E S + P + ++ + + PP + S S +S D
Sbjct: 1007 PSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPD 1066
Query: 374 DEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSS 433
+ + ++ S P++ +KS P GG R SS E +S S
Sbjct: 1067 HRSDTSSPEVRQSHSESPSLQSKSQT--------SPKGG------RSRSSSPVTELASRS 1112
Query: 434 EEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKK 493
+ + A+ L + +P+ SR SDS S + + +S ++
Sbjct: 1113 ---------PIRQDRGEFSASPMLKSGMSPEQSR-FQSDSSSYPTVDSNSLLGQSRLETA 1162
Query: 494 PQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALT 553
K P + A+A + + S E K P+ G+S T
Sbjct: 1163 ESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPET 1222
Query: 554 AQNGKAAKNSEEEEE--------EKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKL 605
+ A S ++EE E+ ++ S LK+ + E + + L
Sbjct: 1223 KEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSL 1282
Score = 75.1 bits (183), Expect = 2e-13
Identities = 108/504 (21%), Positives = 186/504 (36%), Gaps = 65/504 (12%)
Query: 167 SDSDSDSSSED--------EPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSS 218
SDS D SS D + P + PK + ++ + P P + K + S
Sbjct: 142 SDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSE 201
Query: 219 SSS-------SSSSSSDDSEEEKAAATPKKTVPK---KQVVAKAPVKAATTPTRKS---- 264
SSS SS SE E + PK K K +TTP KS
Sbjct: 202 SSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAH 261
Query: 265 -SSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPP---KKSLGTQPPKKAVEKQQPVE 320
S+S DS+S + + + +++ +P P ++ G P +
Sbjct: 262 RSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRP 321
Query: 321 SSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDS--SEDDEAPS 378
SS +++ + SS E+K K K+ T+P P+ + + + + +E
Sbjct: 322 SSPETATKQPSSPYEDKDKDKK---EKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSP 378
Query: 379 KPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKT 438
+P TT S +++ + + PK P K SSS E S S +
Sbjct: 379 QPLATTPLSQEPVNPPSEASPTRDRSPPKSP---------EKLPQSSSSESSPPSPQPTK 429
Query: 439 KKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVA 498
A++ P++ A AP R+ SS S + K KS P +
Sbjct: 430 VSRHASSSPESPKPA-------PAPGSHREISSSPTSKNRSHGRAKRDKSH-SHTPSRRM 481
Query: 499 GGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSP---RPQAPKANGTSALTAQ 555
G + PA+AK+G++ S + S + + + + R ++P+ G S +
Sbjct: 482 GRS--RSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQR 539
Query: 556 NGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEA-------ETPQAKKIKLQTP 608
G + + + + A S S S R ++ + A TP ++ + +TP
Sbjct: 540 PGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTP 599
Query: 609 NTFPKR-----KKGEKRASSPFRR 627
R ++G R+ +P RR
Sbjct: 600 TRRRSRSRTPARRGRSRSRTPARR 623
Score = 74.7 bits (182), Expect = 3e-13
Identities = 94/422 (22%), Positives = 149/422 (35%), Gaps = 69/422 (16%)
Query: 73 PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEES 132
P+ +A+ + S S E P ++ P++ + LPP + ++ S+
Sbjct: 2400 PLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSL-LPPAQDQPRSPVPSAFS-- 2456
Query: 133 SDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTV 192
DQ + + + + + A ++ S D + P P
Sbjct: 2457 -------DQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEP 2509
Query: 193 KAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKA 252
A T A A AA + A + +SSSSSSSSSSSS S
Sbjct: 2510 PASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSS------------------ 2551
Query: 253 PVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKA 312
SSSS SSS + E P++ + VP P+ P + +PP+
Sbjct: 2552 -----------SSSSSGSSSSDSEGSSLPVQPEVA-LKRVPSPTPAPKEAVREGRPPEPT 2599
Query: 313 VEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSE 372
K++ SS SS S SSS SSS SS S SS
Sbjct: 2600 PAKRKRRSSSSSSSSSSSSSS---------------------------SSSSSSSSSSSS 2632
Query: 373 DDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSS 432
+ S + ++ +SS PA KPA+ K P G + RK S + S S
Sbjct: 2633 SSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLS 2692
Query: 433 SEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKK 492
+ ++ P+ ++ +++ +G DS S S E + + +
Sbjct: 2693 YSPVERRRPSPQPSPRDQQSSSSERGSRRGQRG--DSRSPSHKRRRETPSPRPMRHRSSR 2750
Query: 493 KP 494
P
Sbjct: 2751 SP 2752
Score = 71.2 bits (173), Expect = 3e-12
Identities = 93/567 (16%), Positives = 202/567 (35%), Gaps = 18/567 (3%)
Query: 69 QANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSS 128
++ P + + K + E S E Q A+ R G S+S
Sbjct: 1496 RSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSG---SSQELDVKPSAS 1552
Query: 129 SEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKIT 188
+E S+ D D K + + ++ ++++ +P +KS S S S P KP+
Sbjct: 1553 PQERSESDSSPDSKAK-TRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAA 1611
Query: 189 PVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSD-DSEEEKAAATPKKTVPKKQ 247
P ++ + + P+P AP+ ++ S SSS S + S E + P K+ ++
Sbjct: 1612 P-RAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARR 1670
Query: 248 VVAKAP---VKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSL 304
+P K+ T P R+SS S + + ++ P + P P ++S
Sbjct: 1671 GSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTP--PRHRRSP 1728
Query: 305 GTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKP---PTKAVVSKATTKPPPAKKAAES 361
P+ A + + SS + ++S + P P S++ ++ +
Sbjct: 1729 SVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRR 1788
Query: 362 SSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKA 421
S +S + + T+ ++SPA + ++ G+ +R
Sbjct: 1789 DRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGR---SRTP 1845
Query: 422 DSSSSEEESSSSEEE-KTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEE 480
+S S +S K + A+ +++ L +++ + S S S
Sbjct: 1846 PTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTS 1905
Query: 481 EEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPR 540
+ S+S ++ + P + + ++ S + + + + P
Sbjct: 1906 VTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPV 1965
Query: 541 PQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQA 600
+ + TS +T + ++ + + + + V + + + TP A
Sbjct: 1966 TRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPA 2025
Query: 601 KKIKLQTPNTFPKRKKGEKRASSPFRR 627
+ + ++ RK+ R+ RR
Sbjct: 2026 IRRRSRSRTPLLPRKRSRSRSPLAIRR 2052
Score = 68.9 bits (167), Expect = 1e-11
Identities = 120/585 (20%), Positives = 217/585 (37%), Gaps = 85/585 (14%)
Query: 59 KSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGK 118
KS P R ++ P K+ K K S S SS +V+ G PP +
Sbjct: 807 KSRTPPRRSRSSSSPPPKQ-KSKTPSRQSHSSSSPHPKVKS-------------GTPPRQ 852
Query: 119 AAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAA--KAPPKKAKSSDSDSDSSSE 176
+ + +++ ++ V PQ ++ +P + KS S S
Sbjct: 853 GSITSPQAN-------------------EQSVTPQRRSCFESSPDPELKSRTPSRHSCSG 893
Query: 177 DEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAA 236
PP+ VK+ T P+R++ KA S S S SS S +
Sbjct: 894 SSPPR----------VKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTS 943
Query: 237 ATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPS 296
T + + + + SSS D+ E ++ PY V +
Sbjct: 944 RTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQT 1003
Query: 297 APPPKKSLGTQPPKKAVEKQQPVESSEDS----SDESDSSSEEEKKPPTKAVVSKATTKP 352
P P S P + K V+S S + S+ E ++ K ++
Sbjct: 1004 PPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQT 1063
Query: 353 PPAKKAAESSSD----SSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKP----AA 404
P ++ SS + S+S S + S G +++SS + ++SP + +A
Sbjct: 1064 SPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSA 1123
Query: 405 APKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQ 464
+P G + ++DSSS S+S +++ A +K K ++LP ++
Sbjct: 1124 SPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEK------MALPPQEDAT 1177
Query: 465 GSRDSSSDSDSSSSEEEEEKTS---KSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSS 521
S D S ++ ++S K ++ P++ +G A S P + ++ A +SS
Sbjct: 1178 ASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSG--AGSSPETKEQNSA--LPTSS 1233
Query: 522 SDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSG 581
D+ E EK S P + S+ + + S E EE+ ++ + +S
Sbjct: 1234 QDEELMEVVEK-----SEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQS- 1287
Query: 582 SLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFR 626
Q++A+ EA + P+ P+ K + ++SP R
Sbjct: 1288 ------QSQASLEAVEVPSMASSWGGPHFSPEHK---ELSNSPLR 1323
Score = 63.5 bits (153), Expect = 6e-10
Identities = 102/486 (20%), Positives = 175/486 (36%), Gaps = 113/486 (23%)
Query: 264 SSSSEDSSSDEEE----EQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPV 319
S S D SS + + E K+P P PYS V ++S ++ P KQ+
Sbjct: 142 SDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLV--------RESSSSRSP---TPKQKKK 190
Query: 320 ESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSK 379
+ +D S+SSS ++ KK+++ S+S+S +
Sbjct: 191 KKKKDRGRRSESSSPRRER-----------------KKSSKKKKHRSESESKKRKHRSPT 233
Query: 380 PAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTK 439
P K+ K +S + P APK +R+A S+S + +SSS+ +++
Sbjct: 234 PKSKRKSKDKK---RKRSRSTTP--APK----------SRRAHRSTSADSASSSDTSRSR 278
Query: 440 KMVATTKPKATAKAALS-------------------LPAKQAPQGSRDSSSDSDSSSSEE 480
A K TA A S + Q P ++ S ++
Sbjct: 279 SRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDK 338
Query: 481 EEEKTSKSAVKKKPQKVAGGAAPSKPA---------------------SAKKGKAESSNS 519
+++K KSA + P P PA S + S S
Sbjct: 339 DKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEAS 398
Query: 520 SSSDDSSEEEEEKLKGKGS-----PRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAA 574
+ D S + EKL S P PQ K + ++ + ++ K A E
Sbjct: 399 PTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHRE------ 452
Query: 575 VVVSKSGSLKKRKQNEAAKE---AETPQAKKIKLQTPNTFPK--------RKKGEKRASS 623
+S S + K R A ++ + TP + + ++P T + K+G R+ S
Sbjct: 453 --ISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRS 510
Query: 624 P-FRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSY 682
P +RR R + SR ++ W R+ + + +S R ++ + +
Sbjct: 511 PQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGW-SRSRNTQRRGRSRSARRGRSHSRSPAT 569
Query: 683 RGGSIS 688
RG S S
Sbjct: 570 RGRSRS 575
Score = 62.8 bits (151), Expect = 1e-09
Identities = 119/567 (20%), Positives = 202/567 (35%), Gaps = 60/567 (10%)
Query: 100 PPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKA 159
PP+ AA A R+ P + ++ + + + P +A+
Sbjct: 2196 PPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLAS--------RIPAASAAAMNLASART 2247
Query: 160 P--PKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVK-AQTKAPPKPA-----RAAPKIAN 211
P P +DS + +++ + + + P V A + P PA P
Sbjct: 2248 PAIPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALA 2307
Query: 212 GKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSS 271
+ + S + ++++ S A V + A APV A + T + + +
Sbjct: 2308 ALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLT 2367
Query: 272 SDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPP--KKAVEKQQPVESSEDSSDES 329
S + P + S P SA + S T PP +A + P S+ S
Sbjct: 2368 S----ARMAPALSGANLTSPRVPLSAYE-RVSGRTSPPLLDRARSRTPPSAPSQ-----S 2417
Query: 330 DSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKP-AGTTKNSS 388
+SE P ++ + + + PPA+ S S+ SD S A + P AG+ SS
Sbjct: 2418 RMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSS 2477
Query: 389 NKPAVTTKS------------PAVKPAAAPKQPVGGG----------QKLLTRKADSSSS 426
A TT S P V + + P G Q R++ SSSS
Sbjct: 2478 GAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSS 2537
Query: 427 EEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTS 486
SSSS + +++ ++ SLP + R S + E
Sbjct: 2538 SSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPE 2597
Query: 487 KSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKA 546
+ K+K + + ++ S +S+ + SS+SSSS SS SP P P
Sbjct: 2598 PTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS-SSSSSPSPAKP-- 2654
Query: 547 NGTSAL-TAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKL 605
G AL + K E +K + S SL + + +PQ
Sbjct: 2655 -GPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSL---SYSPVERRRPSPQPSPRDQ 2710
Query: 606 QTPNTFPKRKKGEKRAS-SPFRRVREE 631
Q+ ++ ++G++ S SP + R E
Sbjct: 2711 QSSSSERGSRRGQRGDSRSPSHKRRRE 2737
Score = 58.5 bits (140), Expect = 2e-08
Identities = 65/293 (22%), Positives = 110/293 (37%), Gaps = 28/293 (9%)
Query: 357 KAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKL 416
+AA SDS SS D + ++ A KP + + + PKQ +K
Sbjct: 136 RAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKD 195
Query: 417 LTRKADSSSSEEESSSSEEEK----------------TKKMVATTKPKATAKAALSLPAK 460
R+++SSS E S ++K T K +K K ++ + PA
Sbjct: 196 RGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAP 255
Query: 461 QAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAE---SS 517
++ + R +S+DS SSS + S+SA K G +PS PAS ++G+ + S
Sbjct: 256 KSRRAHRSTSADSASSS--DTSRSRSRSAAAKTHTTALAGRSPS-PASGRRGEGDAPFSE 312
Query: 518 NSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVV 577
++S E K SP K + T + ++S E +
Sbjct: 313 PGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAE 372
Query: 578 SKSGSLKKRKQNEAAKEAETPQAK------KIKLQTPNTFPKRKKGEKRASSP 624
GS + ++E P ++ + ++P P+ E SP
Sbjct: 373 RHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSP 425
Score = 57.8 bits (138), Expect = 3e-08
Identities = 122/621 (19%), Positives = 226/621 (36%), Gaps = 79/621 (12%)
Query: 69 QANGPVAKKAKKKASSSDSEDSSEEEEEVQGP-PAKKAAVPAKRVGLPPGKAAAKASESS 127
Q + P K K K S + S E GP P + A+R G P A
Sbjct: 330 QPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQE 389
Query: 128 SSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKI 187
S+ D+ + + + + +PP + S SSS P++ KP
Sbjct: 390 PVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSS----PESPKPAP 445
Query: 188 TPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQ 247
P + + + +P R+ + K+ S + S S + ++ + + +
Sbjct: 446 APGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGH 505
Query: 248 VVAKAPV----------KAATTPTRKSSSSED-----SSSDEEEEQKKPMKNKPGPYSSV 292
+++P + +P R+ S S S + + + + G S
Sbjct: 506 SRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSR 565
Query: 293 PPP------SAPPPK--KSLGTQPPKKAVEKQQPVESSEDS-----SDESDSSSEEEKKP 339
P S P + +S P ++ + P S S S + ++
Sbjct: 566 SPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRS 625
Query: 340 PTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPA-----VT 394
T++ V + + PA+++ S S + P++ ++ S PA
Sbjct: 626 RTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRG---RSRSRTPARRSGRSR 682
Query: 395 TKSPAVKPAAAPKQPVGG--GQKLLTRKADSSSSEEE----SSSSEEEKTKKMVA----- 443
+++PA + + + P G + L R+ S S + S SS E K K +
Sbjct: 683 SRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSR 742
Query: 444 ------TTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKT------SKSAVK 491
K + +++ + SL + ++ SR S S S SS ++K+ S+S
Sbjct: 743 SNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSS 802
Query: 492 KKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRP---QAPKANG 548
+ K S+ +S+ K +S S SS K+K PR +P+AN
Sbjct: 803 QPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANE 862
Query: 549 TSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQN-----EAAKEAETPQAKKI 603
S +T Q ++ S + E K + S SGS R ++ ++ + +PQ K
Sbjct: 863 QS-VTPQR-RSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVK 920
Query: 604 KLQTPNTFPKRKKGEKRASSP 624
+ +P R++ +SSP
Sbjct: 921 AIISP-----RQRSHSGSSSP 936
Score = 39.7 bits (91), Expect = 0.010
Identities = 37/182 (20%), Positives = 76/182 (41%), Gaps = 8/182 (4%)
Query: 472 DSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEE 531
+ D + +EE + AV + Q A ++ + + A + S D SS + +
Sbjct: 100 EKDVNPGGKEETPGQRPAVTETHQL----AELNEKKNERLRAAFGISDSYVDGSSFDPQR 155
Query: 532 KLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEA 591
+ + P P+ PK ++ + ++++++K + S S +++K ++
Sbjct: 156 RAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKK 215
Query: 592 AKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAA 651
K ++KK K ++P KRK +K+ +R R SR A S A ++
Sbjct: 216 KKHRSESESKKRKHRSPTPKSKRKSKDKKR----KRSRSTTPAPKSRRAHRSTSADSASS 271
Query: 652 GD 653
D
Sbjct: 272 SD 273
Score = 36.2 bits (82), Expect = 0.11
Identities = 58/347 (16%), Positives = 123/347 (35%), Gaps = 35/347 (10%)
Query: 61 AKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAA 120
++V R+ +G ++ ++ SS S S + PP + ++ P ++
Sbjct: 1808 SRVTRRRRGGSGYHSRSPARQESSRTS--SRRRRGRSRTPPTSRKRSRSRTSPAPWKRSR 1865
Query: 121 AKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPP 180
++AS ++ S + P+ + +++ + ++++S S + S
Sbjct: 1866 SRASPATHRRSRS---------RTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRS----- 1911
Query: 181 KNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK 240
+ + +PV+ + P R + S S + + S T +
Sbjct: 1912 ---RSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRR 1968
Query: 241 KTVPKKQVVAKAPVKAATTP-TRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPP 299
++ + + + ++ T+P TR+ S S S + + S PP+
Sbjct: 1969 RSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRR 2028
Query: 300 PKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAA 359
+S P+K + P+ S + P A ++ T+ PPA +
Sbjct: 2029 RSRSRTPLLPRKRSRSRSPLAIRRRS----------RSRTPRTARGKRSLTRSPPAIRRR 2078
Query: 360 ESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAP 406
+S SSD S + PA + S P V S + + P
Sbjct: 2079 SASGSSSDRSRS-----ATPPATRNHSGSRTPPVALNSSRMSCFSRP 2120
Score = 33.5 bits (75), Expect = 0.69
Identities = 96/542 (17%), Positives = 183/542 (33%), Gaps = 67/542 (12%)
Query: 59 KSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGK 118
++ V R+ ++ P ++ S S + + + PP + ++ + +
Sbjct: 1926 RTPPVTRRRSRSRTPTTRRR----SRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRR 1981
Query: 119 AAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDE 178
+ ++ S + S ++ + V + ++ PP + S S +
Sbjct: 1982 SRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLL---- 2037
Query: 179 PPKNQKPKITPVTVKAQTKA-PPKPAR-------AAPKIANGKAASSSSSSSSSSSSDDS 230
P+ + +P+ ++ ++++ P+ AR + P I A+ SSS S S++ +
Sbjct: 2038 -PRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPAT 2096
Query: 231 EEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSS--------SEDSSSDEEEEQKKPM 282
+ TP + ++ + + TP + S S + ++ M
Sbjct: 2097 RNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQAGGSM 2156
Query: 283 KNKPGP------YSSVPPPSAPP------PKKSLGTQPPKKAVE--------KQQPVESS 322
+ PGP +SVP A SLGT P ++ Q P
Sbjct: 2157 MDGPGPRIPDHQRTSVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVP 2216
Query: 323 EDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDS--------SDSDSSEDD 374
S + +++ + P A + PA A + +DS + S
Sbjct: 2217 LMSLRTAPAANLASRIPAASAAAMNLASARTPAIPTAVNLADSRTPAAAAAMNLASPRTA 2276
Query: 375 EAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSE 434
APS + PAV A A G G SSS ++ +S
Sbjct: 2277 VAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASA 2336
Query: 435 EEKTKKMVATTKP-------KATAKAALSL-PAKQAP--QGSRDSSSDSDSSSSEEEEEK 484
+ T P A A A SL A+ AP G+ +S S+ E +
Sbjct: 2337 NLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGR 2396
Query: 485 TSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAP 544
TS + + + PS P+ ++ + + SS + + + PR P
Sbjct: 2397 TSPPLLDRARSR----TPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVP 2452
Query: 545 KA 546
A
Sbjct: 2453 SA 2454
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 89.4 bits (220), Expect = 1e-17
Identities = 133/595 (22%), Positives = 197/595 (33%), Gaps = 60/595 (10%)
Query: 72 GPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKA-AVPAKRVGLPPGKAAAKASESSSSE 130
G +A K A ++ + + + PP K A PA P G A + + + +
Sbjct: 1138 GGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTT 1197
Query: 131 ESSDDDDEEDQKKQPVQKGV---------KPQAKAAKAPPKKAKSSDSDSDSSSED---- 177
++ + P KG P+ A PK A ++ + + S +
Sbjct: 1198 PAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPAT 1257
Query: 178 EPPKNQK--PKITPVTVKAQTKAPP-----KPARAAPKIANGKAASS---------SSSS 221
PPK P TP ++K PP PA P G A+S +++
Sbjct: 1258 PPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATP 1317
Query: 222 SSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKP 281
S S + K A TP P P ATTP+ K + SS +
Sbjct: 1318 PSPKGSPGTPPPKGAPTPPAVTPPSP--KGTPTLPATTPSSKGGPTTPSSKEGPTPPAAT 1375
Query: 282 MKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPT 341
+K GP + P P P S P AV P ++ + + E P+
Sbjct: 1376 PSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAP------ATPVTREGAATPS 1429
Query: 342 KAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVK 401
K ++ P KKA +S+ + P+ PA T + PA + +
Sbjct: 1430 KGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSS 1489
Query: 402 PAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKAT-----AKAALS 456
P AP P G L SS E ++ S AT K T K AL
Sbjct: 1490 PKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALI 1549
Query: 457 LPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSK----PASAKKG 512
PA P + + + + K + S P G +P + PA
Sbjct: 1550 PPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPS 1609
Query: 513 KAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKK 572
E+ + S E KG +P APK TS + + K
Sbjct: 1610 PKEAPTPPAVTPPSPE-----KGPATP---APKGTPTSPPVTPSSLKDSPTSPASVTCKM 1661
Query: 573 AAVVVSKSGSLKKRKQNEAAKE---AETPQAKKIKLQTPNTFPKRKKGEKRASSP 624
A V S L +K A KE A P++ I P+ KK A+SP
Sbjct: 1662 GATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSS--ATSP 1714
Score = 77.4 bits (189), Expect = 4e-14
Identities = 117/549 (21%), Positives = 176/549 (32%), Gaps = 51/549 (9%)
Query: 95 EEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQA 154
++V G A P V P + + S +S++ S P+ V PQ
Sbjct: 749 KKVDGISHTSALAP---VASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQT 805
Query: 155 KAAKAPPKKAKSSDSDSDSSSEDEP---------PKN----QKPKITPVTVKAQT----K 197
K PP K S+ D+ + P P+N Q K +P T + T K
Sbjct: 806 KR---PPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPK 862
Query: 198 APPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAA 257
P P+ P G + + S + +E A K P + + +P KA
Sbjct: 863 GAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKAR 922
Query: 258 TTPTRKS-SSSEDSSSDEEEEQKKPMKNKPGPYSSVP-----PPSAPPPKKSLGTQPPKK 311
TP K +S P K GP + P PP+A PP G P
Sbjct: 923 ATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSP 982
Query: 312 AVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKK-----------AAE 360
P ++ S + ++ K PT V+ + K PA A
Sbjct: 983 KGAPTPP--AATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATP 1040
Query: 361 SSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTT-KSPAVKPAAAPKQPVGGGQKLLTR 419
S S + + AP+ PA T + PA + K PAA P P GG
Sbjct: 1041 PSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPA----- 1095
Query: 420 KADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSE 479
S ++ K +AT K + P +P+G + + ++
Sbjct: 1096 -TPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPP--SPKGGLATPPPKGAPTTP 1152
Query: 480 EEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSP 539
+ K + P K A + P S K G A S + + G +P
Sbjct: 1153 AATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATP 1212
Query: 540 RPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQ 599
P+ + + G A S + A K G + A TP
Sbjct: 1213 SPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPP 1272
Query: 600 AKKIKLQTP 608
+ K L TP
Sbjct: 1273 SLKGGLATP 1281
Score = 75.5 bits (184), Expect = 2e-13
Identities = 118/537 (21%), Positives = 186/537 (34%), Gaps = 74/537 (13%)
Query: 105 AAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKA 164
AA P+K PP ++ ++ K P V P + PK+
Sbjct: 1425 AATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQV 1484
Query: 165 KSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSS 224
+S SS + P P P T+ A + PK A P A +++ S
Sbjct: 1485 ATS------SSPKKAPATPAPMGAP-TLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKK 1537
Query: 225 SSSDDSEEEKAAATPKKTVP--KKQVVAKAPVKAATTPTRKSSSSEDS--------SSDE 274
+ + + +E A P TVP KK P +A TP+ K +SS + +
Sbjct: 1538 TPATLAPKE-ALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSP 1596
Query: 275 EEEQKKPMKNKPGPYSSVPPPSAPPPKKSLG-TQPPKKAVEKQQPVESSEDSSDESDSSS 333
+E P P P + PP+ PP G P K PV S + +S
Sbjct: 1597 KELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPAS 1656
Query: 334 EEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDE---APSKPAGTTKNSS-N 389
K T SK PAKK + + + + E AP++ TK SS
Sbjct: 1657 VTCKMGATVPQASKGL----PAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSAT 1712
Query: 390 KPAVT--------TKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKM 441
P + +K P A AP PV + D+S S + + E K
Sbjct: 1713 SPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTP 1772
Query: 442 VATT-------KPKATAKAA-----LSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSA 489
+ KP++ + +A +SLP +P + SS E SK
Sbjct: 1773 LTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPL 1832
Query: 490 VKKK---------PQKVAGGAA----------------PSKPASAKKGKAESSNSSSSDD 524
P+ ++GG P SAK+ +++ S ++
Sbjct: 1833 APADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTES 1892
Query: 525 SSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSG 581
S+E +L+ + S QA A A+ + + ++ +KKA +SK G
Sbjct: 1893 DSDESVPELEEQDS--TQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLG 1947
Score = 72.0 bits (175), Expect = 2e-12
Identities = 118/571 (20%), Positives = 175/571 (30%), Gaps = 49/571 (8%)
Query: 74 VAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLP----------PGKAAAKA 123
+ + KKA ++ + +G P AA P G P P A +
Sbjct: 913 MTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPS 972
Query: 124 SESSSSEESSDDDDEEDQKKQPVQKG--VKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPK 181
+ + S P KG P K A PP S S +++
Sbjct: 973 PKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGA 1032
Query: 182 NQKPKITPVTVKAQTKAPP-------KPARAAPKIANGKAASSSSSSSSSSSSDDSEEEK 234
+ P TP + K A P PA P G A S + + ++ +
Sbjct: 1033 STPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKG 1092
Query: 235 AAATPK-KTVPKKQVVA-KAPVKAATTPTRKSSSSEDSSSDEEEE---QKKPMKNKPGPY 289
ATP K P +P TP K + + +++ + P K P
Sbjct: 1093 GPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAP--- 1149
Query: 290 SSVPPPSAPPPKKSLGTQPPK-----KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAV 344
+ P + P PK L T PPK A P S + ++ P K
Sbjct: 1150 -TTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGG 1208
Query: 345 VSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAA 404
++ + K P AA S + AP+ PA T + PA A P A
Sbjct: 1209 LATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPA 1268
Query: 405 APKQPVGGGQKLLTRKADSSSS--EEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQA 462
A + GG K + + S + A T P AT + P
Sbjct: 1269 ATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPP 1328
Query: 463 PQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPA---SAKKGKAESSNS 519
P+G+ + + S + + K P + P+ PA S K G A + S
Sbjct: 1329 PKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPS 1388
Query: 520 --------SSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKK 571
S D + L K +P A A T G + KK
Sbjct: 1389 PKRGPAIPSPKGDPTSPAVIPLSPKKAP---ATPVTREGAATPSKGDLTPPAVTPVSLKK 1445
Query: 572 KAAVVVSKSGSLKKRKQNEAAKEAETPQAKK 602
A K G + + A TP + K
Sbjct: 1446 APATSAPKGGPATPSSKGDPTLPAVTPPSPK 1476
Score = 63.5 bits (153), Expect = 6e-10
Identities = 111/491 (22%), Positives = 162/491 (32%), Gaps = 58/491 (11%)
Query: 161 PKKAKSSDSDSDSSSEDEPPKN---QKPKITPVTVKAQTKAPP-KPARAAPKIANGKAAS 216
PK+ + DS + +++ + P V+V QTK PP K A P G +S
Sbjct: 767 PKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSS 826
Query: 217 SSSSSSSS-----SSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSS 271
S +S S S ++ A T T P + AP +A TP +
Sbjct: 827 PVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPK---GAPTPSAVTPLSPKGVT---- 879
Query: 272 SDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDS 331
P K P P + P PK+ T PK+A P S SS +
Sbjct: 880 --------LPPKETPTP----SVVNLPFPKEGPATPAPKQA-----PALSMTSSSPKKAR 922
Query: 332 SSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKP 391
++ P K + + + K P AA S + AP+ PA T + P
Sbjct: 923 AT-----PAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGP 977
Query: 392 AV-TTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESS--SSEEEKTKKMVATTKPK 448
A + K PAA P P GG + A + + S S A+T P
Sbjct: 978 ATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPA 1037
Query: 449 ATAKAALSLP-AKQAPQGSRDSSSDSDSSSSEEEEEKTSKSA----VKKKPQKVAGGAAP 503
AT + P A P+G+ + + + S + K A P G A P
Sbjct: 1038 ATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATP 1097
Query: 504 S----------KPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALT 553
S P S K G A + + + G +P P+ +
Sbjct: 1098 SPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPP 1157
Query: 554 AQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPK 613
+ G A + A K G + A TP + K L TP+ PK
Sbjct: 1158 SPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPS--PK 1215
Query: 614 RKKGEKRASSP 624
A+ P
Sbjct: 1216 GAPTTPAATPP 1226
Score = 36.6 bits (83), Expect = 0.081
Identities = 46/217 (21%), Positives = 84/217 (38%), Gaps = 20/217 (9%)
Query: 59 KSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGK 118
KSA +P A PV K K + SDS++S E EE A +
Sbjct: 1866 KSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEE 1925
Query: 119 AAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAK------SSDSDSD 172
+KA +S S E+ +K + G++ + +K+K +
Sbjct: 1926 PVSKAKQSRS---------EKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYK 1976
Query: 173 SSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEE 232
S + D + KI ++ +AQ A K K+ ++ ++ + + ++SEE
Sbjct: 1977 SPASDTYIVFGEAKIEDLSQQAQLAAAEK-----FKVQGEAVSNIQENTQTPTVQEESEE 2031
Query: 233 EKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSED 269
E+ T + + V+++A V A ++S D
Sbjct: 2032 EEVDETGVEVKDIELVMSQANVSRAKAVRALKNNSND 2068
Score = 34.3 bits (77), Expect = 0.40
Identities = 90/402 (22%), Positives = 136/402 (33%), Gaps = 66/402 (16%)
Query: 200 PKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKK---------QVVA 250
P AAP A S SS S+ AA PK+ ++
Sbjct: 446 PCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIPV 505
Query: 251 KAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPK 310
P+ SS +++ Q P + P+S P + KK P
Sbjct: 506 SPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFS--PAQAGLTTKKDPTVLPLV 563
Query: 311 KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSD------ 364
+A K P S +S SSS E P + K+ +P P K A S +
Sbjct: 564 QAAPKNSP-------SFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNS 616
Query: 365 -----SSDSDSSEDDEAP------------------SKPAGT--TKNSSNKPAVTTKSPA 399
+DS + D P + PAG T TT SP
Sbjct: 617 SASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPF 676
Query: 400 VK--PAAAPK-QPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTK-----PKATA 451
++ + APK PV G L T ++SE + + T +AT PK+
Sbjct: 677 LEGTVSLAPKNHPVKEG-TLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVP 735
Query: 452 KAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKK 511
SLP P G++ S +S+ S+ K+ P + +G +A +
Sbjct: 736 SP--SLPPAGTPPGTKKVDGISHTSAL-----APVASSPKECPTEDSGASATASSKGTLT 788
Query: 512 GKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALT 553
A+S + S + + K KGS P P N +S ++
Sbjct: 789 YLADSPSPLGVSVSPQTKRPPTK-KGSAGPDTPIGNLSSPVS 829
Score = 32.7 bits (73), Expect = 1.2
Identities = 91/417 (21%), Positives = 130/417 (31%), Gaps = 77/417 (18%)
Query: 151 KPQAKAAKAPPKKAKSSDSDSDSSSEDEPPK-NQKPKITPVTVKAQTKAPPKPARAAPKI 209
+PQA+ A P A S + PP + P+ P++ Q P P+ A
Sbjct: 18 QPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIA--- 74
Query: 210 ANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSED 269
+ SSS ++ + E P P A A PT K + S
Sbjct: 75 STPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPMIAPTLKGTPSSS 134
Query: 270 SSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDES 329
+ P+ SV SA PP +L T PP AV + V + S
Sbjct: 135 A----------PLALVALAPHSVQKSSAFPP--NLLTSPPSVAVAESGSVITLSAPIAPS 182
Query: 330 DSSSEEEKKPPTKAVVSKATTKPP----------------------------PAKKAAES 361
+ + K P K T PP P A +
Sbjct: 183 EPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIA 242
Query: 362 SSDSSDSDSSEDDEAP------------SKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQP 409
S D+ S +P S PA + ++ + P VT+ P P P
Sbjct: 243 SPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPDFP 302
Query: 410 VGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDS 469
+ G L S S + ++ T P +ALS P + S D
Sbjct: 303 ISLGSHLAPLHQSSFGSVQ------------LLGQTGP-----SALSDPTVKTI--SVDH 343
Query: 470 SSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSS 526
SS S S+ S + P VA A P S KG + S+ + S S
Sbjct: 344 SSTGASYPSQRSVIPPLPSRNEVVPATVA--AFPVVAPSVDKGPSTISSITCSPSGS 398
Score = 32.7 bits (73), Expect = 1.2
Identities = 43/211 (20%), Positives = 70/211 (33%), Gaps = 20/211 (9%)
Query: 70 ANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSS 129
A P+ K + ++ +D+S + PP KA+ P + ES+S
Sbjct: 1734 APAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAF---EKVLPKPESASV 1790
Query: 130 EESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDE-----PPKN-- 182
+ PV Q +P +S + EDE PP+
Sbjct: 1791 SAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPIS 1850
Query: 183 -----QKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAA 237
Q + T K+ P P+ P N K + + S S S + ++ A
Sbjct: 1851 GGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQAT 1910
Query: 238 TPKKTVPKKQVVAKAPVKAATTPTRKSSSSE 268
T + + + + PV A K S SE
Sbjct: 1911 TQQAQLAAAAEIDEEPVSKA-----KQSRSE 1936
>gi|125656165 THO complex 2 [Homo sapiens]
Length = 1593
Score = 88.6 bits (218), Expect = 2e-17
Identities = 86/415 (20%), Positives = 160/415 (38%), Gaps = 17/415 (4%)
Query: 92 EEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVK 151
E E + PP + A + PG + +S S+S+ +E D+ ++ Q GVK
Sbjct: 1183 ENEFHHKDPPPRNAVASVQN---GPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVK 1239
Query: 152 PQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIAN 211
KA+ PK SS+ +S S+S +N K K + + K P A +
Sbjct: 1240 AVNKASSTTPK-GNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKD 1298
Query: 212 GKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSS 271
GK + + +++E + +K KK+ AK T P +S S+++
Sbjct: 1299 GKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQERE 1358
Query: 272 SDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAV---EKQQPVESSEDSSDE 328
++E +++ + + +V P SL + P+ + E++Q +
Sbjct: 1359 REKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSP 1418
Query: 329 SDSSSEEEKKPPTKAVVSK--ATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKN 386
S SS+ ++ K +K PPP K+ E D D D S + +
Sbjct: 1419 SHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDR 1478
Query: 387 SSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTK 446
K + V P ++ G +++ S E + ++++ K ++ K
Sbjct: 1479 KERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGK 1538
Query: 447 PKATAKAALSLPAKQAPQGSRDSSSDSD--------SSSSEEEEEKTSKSAVKKK 493
K + K + G ++S D + SS +EE+K KS+ K +
Sbjct: 1539 EKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
Score = 80.9 bits (198), Expect = 4e-15
Identities = 94/426 (22%), Positives = 177/426 (41%), Gaps = 24/426 (5%)
Query: 181 KNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK 240
K++K + P PP+ A A+ + G SSSS S+S S + S EE
Sbjct: 1174 KSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEE-----TD 1228
Query: 241 KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDE----EEEQKKPMKNKPGPYSSVPPPS 296
K+ + Q KA KA++T + +SS+ +S S+ +E K+ K K P +
Sbjct: 1229 KSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPAT 1288
Query: 297 APPPK---KSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPP 353
P + K +P ++ K + +++ + +SD E+ KK KA K T P
Sbjct: 1289 TPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKK-EEKAKDEKFKTTVP 1347
Query: 354 PAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAV--TTKSPAVKPAAAPKQPVG 411
A+ + + S E D A + K V + KSP + +
Sbjct: 1348 NAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQ 1407
Query: 412 GGQKLLTRKADSSSSEEESSSSE-EEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSS 470
+K+ T + S SS + S E +E + K+ P +K+ K+ SR+ S
Sbjct: 1408 KRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERS 1467
Query: 471 SDSDSSSSEEEEEKT---SKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSE 527
+ + ++ +E+ S + + P + K K+ES S + +
Sbjct: 1468 REREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKD 1527
Query: 528 EEEEKLKGKGSPR-PQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKR 586
+E+ K K G + + K+ +++ K +++ +E+ E+K+K SG +++
Sbjct: 1528 KEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKR----DSSGGKEEK 1583
Query: 587 KQNEAA 592
K ++++
Sbjct: 1584 KHHKSS 1589
Score = 76.6 bits (187), Expect = 7e-14
Identities = 101/408 (24%), Positives = 163/408 (39%), Gaps = 51/408 (12%)
Query: 308 PPKKAVEKQQ------PVESSEDSSDESDSSSEEE--KKPPTKAVVSKATTKPPPAKKAA 359
PP+ AV Q P SS S+ +SD SS EE K KA K
Sbjct: 1192 PPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKG 1251
Query: 360 ESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAA---------PKQ-- 408
SS+ +S S+S++ + K G K K K+PA P A PK+
Sbjct: 1252 NSSNGNSGSNSNKAVKENDKEKGKEKEKEKKE----KTPATTPEARVLGKDGKEKPKEER 1307
Query: 409 PVGGGQKLLTRKADSSSSEEESSSSEEEKTK-KMVATTKPKATAKAALSLPAKQAPQGSR 467
P + T++ S +E+ +EEK K + TT P A +K+ ++ P R
Sbjct: 1308 PNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRER 1367
Query: 468 DSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAES----SNSSSSD 523
D + + S + + EKT S K P V P K+ K ++ S+SS+
Sbjct: 1368 DIAKEMKSKENVKGGEKTPVSGSLKSP--VPRSDIPEPEREQKRRKIDTHPSPSHSSTVK 1425
Query: 524 DS---SEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKS 580
DS +E KL +P P K+ K+ + S E E++ +K
Sbjct: 1426 DSLIELKESSAKLYINHTP-PPLSKSKEREMDKKDLDKSRERSREREKKDEK-------- 1476
Query: 581 GSLKKRKQNEAAKEAETPQ--AKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSR 638
K+RK++ + + E P K+ K + + K E SP+ +++E +
Sbjct: 1477 -DRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKE-----K 1530
Query: 639 VADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGS 686
S ++G+ E+ +++ K K RH+K K ++ R S
Sbjct: 1531 NKSKSSGKEKGSDSFKSEKMDKISSGGK-KESRHDKEKIEKKEKRDSS 1577
Score = 57.4 bits (137), Expect = 4e-08
Identities = 80/399 (20%), Positives = 145/399 (36%), Gaps = 61/399 (15%)
Query: 59 KSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGK 118
K++ + +NG + K +D E E+E+E KK PA P +
Sbjct: 1243 KASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKE------KKEKTPAT---TPEAR 1293
Query: 119 AAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQ---AKAAKAPPKKAKSSDSDSDSSS 175
K + EE + D++ + K+ K K + K KA +K K++ +++S S
Sbjct: 1294 VLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKS 1353
Query: 176 EDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKA 235
E + ++P ++ + K ++ + G+ S S S
Sbjct: 1354 TQEREREKEP--------SRERDIAKEMKSKENVKGGEKTPVSGSLKS------------ 1393
Query: 236 AATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPP 295
P+ +P+ + K K T P+ SS+ S E +E + P
Sbjct: 1394 -PVPRSDIPEPEREQKRR-KIDTHPSPSHSSTVKDSLIELKESSAKLYINHTP------- 1444
Query: 296 SAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESD--------SSSEEEKKPPTKAVVSK 347
PP KS + KK ++K + + DE D S+++ E P +
Sbjct: 1445 --PPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKE 1502
Query: 348 ATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPK 407
+K +ES +S + + ++ SK +G K S + K K
Sbjct: 1503 ENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSD----------SFKSEKMDK 1552
Query: 408 QPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTK 446
GG ++ K E+ SS +E+ K ++ K
Sbjct: 1553 ISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDK 1591
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 86.7 bits (213), Expect = 7e-17
Identities = 127/565 (22%), Positives = 216/565 (38%), Gaps = 78/565 (13%)
Query: 87 SEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPV 146
S+ S EE ++ AAV ++ GLP G A+ES S E D P
Sbjct: 46 SQLSEEERRQI-------AAVMSRAQGLPKGSVPPAAAESPSMHRK----QELDSSHPPK 94
Query: 147 QKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQ-----KPKITPVTVKAQTKAPPK 201
Q G +P A P +KS +D+ S + P ++ K + +K + K+
Sbjct: 95 QSG-RPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMM 153
Query: 202 PARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQV-----VAKAPV-K 255
P + A +S + + DSE + T K+ V +K+ + K P+ +
Sbjct: 154 PGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQ 213
Query: 256 AATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPP---PKKSLGTQPPKKA 312
P K ++ K +P S PP + P P ++ T K
Sbjct: 214 QPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLP 273
Query: 313 VEKQQPVESSEDSSDESDSSSEEEKKP----PTKAVVSKATTKPPPAKKAAESSSDSSDS 368
+++ ++S + ++D E KP P+K + + T PPA++ S +
Sbjct: 274 LQR----DASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPA 329
Query: 369 DSSEDDEAPSKPAGTTKNSSNKPAV---------TTKSPA--VKPAAAPKQPVGG----- 412
+ P++P+G TK + +P TTK PA + PA P Q G
Sbjct: 330 ------KPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSS 383
Query: 413 ---GQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDS 469
G K L + + + + T++ V T KP A + L PAK AP ++
Sbjct: 384 EQPGPKALAQPPGVGKTPAQQPGPAKPPTQQ-VGTPKPLA-QQPGLQSPAK-APGPTKTP 440
Query: 470 SSDSDSSSSEEEEEKTSKSAVK-----KKPQKVAGGAAPSK----PASAKKGKAESSNSS 520
++ K++ + K P ++ G A P PA + S+
Sbjct: 441 VQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPP 500
Query: 521 SSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAA----VV 576
S S + + G P PQ P G++ +Q +AK S ++ K +A
Sbjct: 501 SQQPGSTKPPPQQPGPAKPSPQQP---GSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKP 557
Query: 577 VSKSGSLKKRKQNEAAKEAETPQAK 601
VS++GS K + + A+ P ++
Sbjct: 558 VSQTGSGKPLQPPTVSPSAKQPPSQ 582
Score = 73.9 bits (180), Expect = 5e-13
Identities = 128/605 (21%), Positives = 227/605 (37%), Gaps = 90/605 (14%)
Query: 73 PVAKKAKKKASSSDSEDSSEE---------EEEVQGPPAKKAAVPAKRVGLPPGKAAAKA 123
P KK +A +S E+ + EE+++G A K K+ P K
Sbjct: 1243 PEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQ---PQTKMEGLP 1299
Query: 124 SESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQ 183
S + S DD + K+QP Q + + +K + D SD+SS +P Q
Sbjct: 1300 SGTPQSLPKEDDKTTKTIKEQP-QPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQ 1358
Query: 184 KPKITPVTVKAQTKAPPKPARAAPK----IANGKAASSSSSSSSSSSSDDSEE------- 232
T + + + + P I G S S SS SS D +
Sbjct: 1359 GLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLS 1418
Query: 233 --EKAAAT------PKKTVPKKQVVAKAPVKAATTP----TRKSSSSEDSSSDEEEEQKK 280
E A+T KKT P +V + P T T + + SE+ + +EE+K
Sbjct: 1419 ILEAQASTLADEKSEKKTQPH-EVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKD 1477
Query: 281 PMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPP 340
K S PS+ K+ ++ +++P +S E+SS+ +S + K+
Sbjct: 1478 TFKKD----SQQDIPSSKDHKEK--SEFVDDITTRREPYDSVEESSESENSPVPQRKRRT 1531
Query: 341 TKAVVSKATTKPPPAKKAAESS----------SDSSDSDSSEDDEAPSKPAGTTKNSSNK 390
+ S K ++ + E S D+ SEDDE +N +
Sbjct: 1532 SVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEF-------IRNQLKE 1584
Query: 391 PAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESS------------------- 431
+ +T+S + + G + LTRK+ +S E+
Sbjct: 1585 ISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELK 1644
Query: 432 --SSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSA 489
++ ++++++V T + L + A + S +SS S +EE E +S
Sbjct: 1645 YRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESL 1704
Query: 490 VKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQA-PKANG 548
+ G + S AS+ ++ SS D+ S+ KG+ + +A + +G
Sbjct: 1705 TDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHG 1764
Query: 549 TSALTAQNGKAAKNSEEEEE-----EKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKI 603
T ++ + EEEE EK++ + S KK K++ K+ Q ++
Sbjct: 1765 PLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSSKKSKKD---KDELRAQRRRE 1821
Query: 604 KLQTP 608
+ +TP
Sbjct: 1822 RPKTP 1826
Score = 70.9 bits (172), Expect = 4e-12
Identities = 135/594 (22%), Positives = 206/594 (34%), Gaps = 88/594 (14%)
Query: 69 QANGPVAKKAKKKASSSDSEDSSEEEEEVQGP-----PAKK---AAVPAKRVGLPPGKAA 120
Q GP A++ S S + + Q P PA++ A P ++VG P A
Sbjct: 364 QPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQ 423
Query: 121 AKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPP 180
+S + K PVQ Q K P ++A + + + +PP
Sbjct: 424 QPGLQSPAKAPGPT--------KTPVQ-----QPGPGKIPAQQAGPGKTSAQQTGPTKPP 470
Query: 181 KNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK 240
+Q P P Q P KP P + K S S+ + + P
Sbjct: 471 -SQLPG--PAKPPPQQPGPAKPPPQQP--GSAKPPSQQPGSTKPPPQQPGPAKPSPQQPG 525
Query: 241 KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPP 300
T P Q A A K S+ + + + KP++ S+ PPS P
Sbjct: 526 STKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLP 585
Query: 301 K--------KSLGTQPPKKA-----VEKQQPVESSEDSSDESDSSSEEE-------KKPP 340
K L P+KA E Q V S + + +E K
Sbjct: 586 KTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRA 645
Query: 341 TKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDE--APSKPAGTTKNSSNKPAVTTKSP 398
++ + P P K A ++ S+ S SS + +P K A ++ S P P
Sbjct: 646 LGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPP 705
Query: 399 AVK-------PAAAPKQP--VGGGQKLLTRKADSSSSEEESSSSEEEKTK--KMV----- 442
VK P+A KQP K K S SE++ + ++K K KMV
Sbjct: 706 LVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTD 765
Query: 443 ------ATTKPK-ATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQ 495
ATTKP ++K K P DS+ S S E+ S +P
Sbjct: 766 LVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRP- 824
Query: 496 KVAGGAAPSKPASAKKGKAESSNSSSSDD-SSEEEEEKLKGKGSPRPQA-------PKAN 547
A+ SK S +ES D +EE +K + K SP+P A P
Sbjct: 825 -----ASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPP 879
Query: 548 GTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAK 601
G Q + S + +E+ ++ ++ GS+ +++ ET K
Sbjct: 880 GPRPTAGQTVPTPQQSPKPQEQSRRFSL---NLGSITDAPKSQPTTPQETVTGK 930
Score = 69.7 bits (169), Expect = 9e-12
Identities = 114/569 (20%), Positives = 199/569 (34%), Gaps = 47/569 (8%)
Query: 71 NGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSE 130
+GP A + A S + Q PPA ++P K+ P AA+ E + +
Sbjct: 958 SGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAP---AAEKLEPKAEQ 1014
Query: 131 ESSDDDDEEDQKKQPVQ--KGVKPQAKAAKAPPKKAKSSDSDS---------DSSSEDEP 179
+ E ++K P++ K + + + A P K KS +S + S+D P
Sbjct: 1015 APTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPP 1074
Query: 180 PKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATP 239
N T + P +I + + + S D + A +
Sbjct: 1075 NFNT---CTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSG 1131
Query: 240 KKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPP 299
K P + K A P K ++ E E+ K K PP
Sbjct: 1132 PKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTT 1191
Query: 300 PKKSLGTQPPK---KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAK 356
+K ++ K A+++++P+ + E + EEKKP + KP P
Sbjct: 1192 DQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEE------KKPTPED 1245
Query: 357 KAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKL 416
K + +S + + D S+ V ++ APK G Q
Sbjct: 1246 KKLLPEAKTSAPEEQKHDLLKSQ-------------VQIAEEKLEGRVAPKTVQEGKQPQ 1292
Query: 417 LTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSS 476
+ S + + +++ TK + +P TAK P K+ + D SD+ SS
Sbjct: 1293 TKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTE-KEDDKSDTSSS 1351
Query: 477 SSEEEEEKTSKSAVKKKPQKVAGGAAPSK-PASAK---KGKAESSNSSSSDDSSEEEEEK 532
+ + S + + G PS P K KG + S S S SS + K
Sbjct: 1352 QQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAK 1411
Query: 533 LKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAA 592
L+ S +A ++ ++ K + E E+ K S S +L+ E
Sbjct: 1412 LE---STVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEI 1468
Query: 593 KEAETPQAKKIKLQTPNTFPKRKKGEKRA 621
KE++ + K + P K ++++
Sbjct: 1469 KESQEERKDTFKKDSQQDIPSSKDHKEKS 1497
Score = 68.2 bits (165), Expect = 3e-11
Identities = 144/665 (21%), Positives = 233/665 (35%), Gaps = 113/665 (16%)
Query: 61 AKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAA 120
AK P +++ P+A++ S ++ + VQ P K +PA++ G PGK +
Sbjct: 408 AKPPTQQVGTPKPLAQQP---GLQSPAKAPGPTKTPVQQPGPGK--IPAQQAG--PGKTS 460
Query: 121 AKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPP 180
A+ + + K P Q G AK PP++ S+ S +PP
Sbjct: 461 AQQTGPTKPPSQLPGP----AKPPPQQPG------PAKPPPQQPGSAKPPSQQPGSTKPP 510
Query: 181 KNQKPKITPVTVKAQTKAPP-------KPARAAPKIANGKAASSSSSSSSSSS------- 226
Q P + + PP KP+ P A A S+ S + S
Sbjct: 511 PQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPP 570
Query: 227 --SDDSEEEKAAATPKKTVP---KKQVVAKAPVKA--------ATTPTRKSSSSEDSSSD 273
S +++ + PK P +++ P KA TT + +
Sbjct: 571 TVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLT 630
Query: 274 EEEEQ---KKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQP----VESSEDSS 326
E +E MK G P PS+P PK AV K P +D++
Sbjct: 631 EVKEWLCLNCQMKRALGG-DLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAA 689
Query: 327 DESD-SSSEEEKKPPT-------KAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAP- 377
+ D S + E KKPP S +PP A ++ + S SE D+AP
Sbjct: 690 PKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPV 749
Query: 378 --SKPAG-----------TTKNSSNKPAV-----------TTKSPAVKPAAAPKQ---PV 410
KP ++ +++ KP + T P +A P Q P
Sbjct: 750 ADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPT 809
Query: 411 GG-----GQKLLTRKADSSSSEEESSSSEEEKTKKMVATTK-----PKATAKAALSLPAK 460
G K + R A S S E K +K V + KA K + AK
Sbjct: 810 GEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAK 869
Query: 461 QAPQGS------RDSSSDS--DSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKG 512
P+GS R ++ + S + +E++ + ++ A + P+ P G
Sbjct: 870 PMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTG 929
Query: 513 KAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKK 572
K +S +S + G P P + G A S+ + +
Sbjct: 930 KLFGFGASIFSQAS----NLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQ 985
Query: 573 AAVVVSKSGSLKKRKQNEAAK--EAETPQAKKIK-LQTPNTFPKRKKGEKRASSPFRRVR 629
A +KS +KK + AA+ E + QA +K +T P K + + P + V
Sbjct: 986 APPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVL 1045
Query: 630 EEEIE 634
++E
Sbjct: 1046 PTKLE 1050
Score = 65.1 bits (157), Expect = 2e-10
Identities = 122/631 (19%), Positives = 214/631 (33%), Gaps = 82/631 (12%)
Query: 59 KSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGK 118
KS+ P++ K+ KA ++ + G P+ KA P + L
Sbjct: 674 KSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPA 733
Query: 119 AAAKASESSSSEESSDDDDEEDQKKQ-------------------PVQKGVKPQAKAAKA 159
+ S S +++ DD+ Q K P K V+ QA+
Sbjct: 734 PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSK-VQSQAEEKTT 792
Query: 160 PPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSS 219
PP K +DS S+ PP + K++P +KA P+PA + I++ +S S
Sbjct: 793 PPLK-----TDSAKPSQSFPPTGE--KVSPF----DSKAIPRPASDSKIISHPGPSSESK 841
Query: 220 SSSSSSSSDDSEEEKAAATPKKTVPKKQVVAK-APVKAATTPTRKSSSSEDSSSDEEEEQ 278
EE K A T P + + K +P PT + S + +EQ
Sbjct: 842 GQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQ 901
Query: 279 KKPMKNKPGPYSSVPPPSAPPPKKSL---------------------------GTQPPKK 311
+ G + P P++++ +Q
Sbjct: 902 SRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPG 961
Query: 312 AVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSS 371
A KQ P S +S S+ + P K++ K TK P A+K + + +
Sbjct: 962 APMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRT 1021
Query: 372 EDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESS 431
E ++ P P +K+ + +P AV P K P L + + S++ +
Sbjct: 1022 ETEKKP-PPIKDSKSLTAEP-----QKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPN 1075
Query: 432 SSEEEKTKKMVA-----TTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTS 486
+ + K V P T Q + D K S
Sbjct: 1076 FNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKAS 1135
Query: 487 KSAV--KKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAP 544
V + QK A P + KK + E + + +E K P
Sbjct: 1136 PMPVPTESSSQKT---AVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTD 1192
Query: 545 KANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAE-TPQAKKI 603
+ S L A + + EEKK ++ + ++ ++ +E + TP+ KK+
Sbjct: 1193 QKQEESKLEKDKASALQEKKPLPEEKK----LIPEEEKIRSEEKKPLLEEKKPTPEDKKL 1248
Query: 604 KLQTPNTFPKRKKGEKRASSPFRRVREEEIE 634
+ + P+ +K + S ++ EE++E
Sbjct: 1249 LPEAKTSAPEEQKHDLLKSQV--QIAEEKLE 1277
Score = 58.2 bits (139), Expect = 3e-08
Identities = 109/586 (18%), Positives = 206/586 (35%), Gaps = 92/586 (15%)
Query: 63 VPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAK 122
+P K+Q+ +A++K + DS++ + K + +K + P +
Sbjct: 778 IPSSKVQS------QAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKII 831
Query: 123 ASESSSSEESSDDDDEEDQKKQPVQKG---------VKPQAKAAKAPPKKAKSSDSDSDS 173
+ SSE + QKK+ +K KP K + PP ++ +
Sbjct: 832 SHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPT 891
Query: 174 SSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAA-------SSSSSSSSSSS 226
+ P+ Q + + + + + T AP + GK S +S+ S++
Sbjct: 892 PQQSPKPQEQSRRFS-LNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAG 950
Query: 227 SDDSEEEKAAATPKKTVPK-----------KQVVAKAPVKAATTPTRKSSSSEDSSSDEE 275
+ P K P K P A + P +K + + + E
Sbjct: 951 QPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEP 1010
Query: 276 EEQKKPM------KNKPGPYSSVPPPSAPPPKKSLGTQPPKK-AVEKQQPVESSEDSSDE 328
+ ++ P + KP P +A P K L T+ K E P+ +E +
Sbjct: 1011 KAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGS 1070
Query: 329 SDSSSEEEKKPPTKAVVSKATTKPPP----------AKKAAESSSDSSDSDSSEDDEAPS 378
D + V + P P + + D + APS
Sbjct: 1071 KDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPS 1130
Query: 379 KPAGT-----TKNSSNKPAVTTKSPAVKPAAAPKQPV-GGGQKLL--------------- 417
P + T++SS K AV P VK +Q V +K++
Sbjct: 1131 GPKASPMPVPTESSSQKTAV---PPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPP 1187
Query: 418 ----TRKADSSSSEEESSSSEEEK-----TKKMVATTKPKATAKAALSLPAKQAPQGSRD 468
+K + S E++ +S+ +EK KK++ + + + L K+ +
Sbjct: 1188 MVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKK 1247
Query: 469 SSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSN-SSSSDDSSE 527
++ +S+ EE++ KS V+ +K+ G AP K+ + + S + S
Sbjct: 1248 LLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLP 1307
Query: 528 EEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKA 573
+E++K +PQ P TA+ + E+ E+E K+
Sbjct: 1308 KEDDKTTKTIKEQPQPP-------CTAKPDQVEPGKEKTEKEDDKS 1346
Score = 42.7 bits (99), Expect = 0.001
Identities = 66/305 (21%), Positives = 116/305 (38%), Gaps = 28/305 (9%)
Query: 313 VEKQQPVESSEDSSDESDSSSEEEKKPPT----KAVVSKATTKPPPAKKAAESSSDSSDS 368
V +++ + S D+S ++D ++E PT KA V K A K S SS +
Sbjct: 3458 VSRRRRTKKSVDTSVQTDDEDQDEWDMPTRSRRKARVGKYGDSMTEADKTKPLSKVSSIA 3517
Query: 369 -DSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADS-SSS 426
+ + ++P GT + S + V K +K +AP++ GG +ADS + S
Sbjct: 3518 VQTVAEISVQTEPVGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTEADSDTQS 3577
Query: 427 EEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTS 486
+ S++ K KK + ++ + AP + S S S K
Sbjct: 3578 PQYLSATSPPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPK-SPKVLYSPISPLSPGKAL 3636
Query: 487 KSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKA 546
+SA + + +P K K + S + + + P+P +P A
Sbjct: 3637 ESAFVPYEKPLPDDISPQKVLHPDMAKVPPA-------SPKTAKMMQRSMSDPKPLSPTA 3689
Query: 547 NGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQ 606
+ +S Q E K + ++ SG+ KK K + P ++I
Sbjct: 3690 DESSRAPFQ---------YTEGYTTKGSQTMTSSGAQKKVK-----RTLPNPPPEEISTG 3735
Query: 607 TPNTF 611
T +TF
Sbjct: 3736 TQSTF 3740
Score = 42.0 bits (97), Expect = 0.002
Identities = 81/327 (24%), Positives = 119/327 (36%), Gaps = 37/327 (11%)
Query: 88 EDSSEEEEEVQGPPA-----KKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQK 142
EDS E P + ++ +V R P G+A+A S S+ +S + K
Sbjct: 2221 EDSEEISSSTYFPGSIIDYPEEISVSLDRTAPPDGRASADHIVISLSDMASSIIESVVPK 2280
Query: 143 KQ-PVQKGVKPQAKAA-KAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKA-- 198
+ PV V + K P KKAK + E +++K T + ++
Sbjct: 2281 PEGPVADTVSTDLLISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETVF 2340
Query: 199 --PPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKA 256
PP A P S++ +S + +EK A+ P V+ P K
Sbjct: 2341 DHPPSSVIALPM-------KEQLSTTYFTSGETFGQEKPASQLPSGSPS---VSSLPAKP 2390
Query: 257 ATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQ 316
P +SSS + S+ P P P PPP PPP T PKK +
Sbjct: 2391 R--PFFRSSSLDISAQPPPPPPPPPPPPPPPP--PPPPPPLPPPTSPKPTILPKKKLTVA 2446
Query: 317 QPVESSEDSSD-----ESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSS 371
PV ++ D E+ + P T+ TT PPP + SS S +
Sbjct: 2447 SPVTTATPLFDAVTTLETTAVLRSNGLPVTRI----CTTAPPPV--PPKPSSIPSGLVFT 2500
Query: 372 EDDEAPSKPAGTTKNSSNKPAVTTKSP 398
E PSKP K + TT+ P
Sbjct: 2501 HRPE-PSKPPIAPKPVIPQLPTTTQKP 2526
Score = 38.5 bits (88), Expect = 0.021
Identities = 52/219 (23%), Positives = 87/219 (39%), Gaps = 30/219 (13%)
Query: 101 PAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAP 160
P+ +A V AK V + +A + + S + D + Q Q + P+ K P
Sbjct: 3537 PSIRARVDAK-VEIIKHISAPEKTYKGGSLGCQTEADSDTQSPQYLSATSPPKDKKRPTP 3595
Query: 161 PKKAKSSDSDSDSSSE--DEPPKNQKPKITPVTVKAQTKA---------PPKPARAAP-K 208
+ SS +DS+ + PPK+ K +P++ + KA P P +P K
Sbjct: 3596 LEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQK 3655
Query: 209 IANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSE 268
+ + A +S ++ +++ + PK P ++AP + T K S +
Sbjct: 3656 VLHPDMAKVPPASPKTAKM----MQRSMSDPKPLSPTADESSRAPFQYTEGYTTKGSQTM 3711
Query: 269 DSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQ 307
SS QKK + P P PP + S GTQ
Sbjct: 3712 TSSG----AQKKVKRTLPNP---------PPEEISTGTQ 3737
Score = 36.2 bits (82), Expect = 0.11
Identities = 51/236 (21%), Positives = 82/236 (34%), Gaps = 17/236 (7%)
Query: 118 KAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSED 177
K + E E S D ED+ + + + P S D DSDSS
Sbjct: 1688 KTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSS--- 1744
Query: 178 EPPKNQKPKITPVTVKAQTKAPPKP-ARAAPKIANGKAASSSSSSSSSSSSDDSEEE--- 233
P ++K + K Q KA +P P I + + + E
Sbjct: 1745 --PSHKKGES-----KQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQ 1797
Query: 234 --KAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSS 291
+ +++ K K ++ A+ + TP S ED+S EE Q M+ S
Sbjct: 1798 QQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCS 1857
Query: 292 VPPPSAPPPKKSLGTQPPK-KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVS 346
PS + P K V+K + ++ +D S +K+ KA+ S
Sbjct: 1858 EYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQKALKS 1913
Score = 30.4 bits (67), Expect = 5.8
Identities = 61/296 (20%), Positives = 103/296 (34%), Gaps = 31/296 (10%)
Query: 170 DSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDD 229
D D++ + ++ K + V QT + P + KA S + +
Sbjct: 3449 DEDATDRSYVSRRRRTKKS-VDTSVQTDDEDQDEWDMPTRSRRKARVGKYGDSMTEADKT 3507
Query: 230 SEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPY 289
K ++ +TV + V + PV TP+ ++ D+ + + P K G
Sbjct: 3508 KPLSKVSSIAVQTVAEISVQTE-PVGTIRTPSIRARV--DAKVEIIKHISAPEKTYKGGS 3564
Query: 290 ---SSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVS 346
+ P+ T PPK ++ P+E S +DS+ + PP V
Sbjct: 3565 LGCQTEADSDTQSPQYLSATSPPKDK-KRPTPLEIGYSSHLRADSTVQLAPSPPKSPKVL 3623
Query: 347 KATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAP 406
+ P KA ES+ + DD +P K P + PA A
Sbjct: 3624 YSPISPLSPGKALESAFVPYEK-PLPDDISPQKVL--------HPDMAKVPPASPKTAKM 3674
Query: 407 KQPVGGGQKLLTRKADSSS--------------SEEESSSSEEEKTKKMVATTKPK 448
Q K L+ AD SS S+ +SS ++K K+ + P+
Sbjct: 3675 MQRSMSDPKPLSPTADESSRAPFQYTEGYTTKGSQTMTSSGAQKKVKRTLPNPPPE 3730
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 86.7 bits (213), Expect = 7e-17
Identities = 115/551 (20%), Positives = 197/551 (35%), Gaps = 74/551 (13%)
Query: 96 EVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAK 155
+V P K+ + + K AAK S S + S ++ E K V+K K ++K
Sbjct: 524 QVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESK 583
Query: 156 AAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAA 215
K S +E E P ++P V + KP A K
Sbjct: 584 EKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVK---- 639
Query: 216 SSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEE 275
+ +D +EEK PKK V KK+ K P+K P ++ E ++
Sbjct: 640 -----KETKVKPEDKKEEKEK--PKKEVAKKE--DKTPIKKEEKPKKEEVKKEVKKEIKK 690
Query: 276 EEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEE 335
EE+K+P KK + + P K V+K+ E ++ E +E
Sbjct: 691 EEKKEP-------------------KKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKE 731
Query: 336 EKKPPTKAVVSKATTKPPPAKK--AAESSSDSSDSDSSEDDEAPSKP-----------AG 382
KK P A K++T AKK A + + +D A KP G
Sbjct: 732 IKKLPKDA--KKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEG 789
Query: 383 TTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMV 442
+ T + A AAA +G ++L ++ SS E+ + EE K +++
Sbjct: 790 KAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVD 849
Query: 443 AT--TKPK---------------------ATAKAALSLPAKQAPQGSRDSSSDSDSSSSE 479
T KP+ + PA+ +G + + + +
Sbjct: 850 VTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTP 909
Query: 480 EEEEKTSKSAVK--KKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKG 537
EE E K V +K + G S + KAE+ + ++ EE K
Sbjct: 910 EELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKH 969
Query: 538 SPR--PQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEA 595
SP ++ KA + + + A + EE+ +A S ++ + + A++A
Sbjct: 970 SPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDA 1029
Query: 596 ETPQAKKIKLQ 606
+ + K++
Sbjct: 1030 REEEYEPEKME 1040
Score = 69.3 bits (168), Expect = 1e-11
Identities = 126/611 (20%), Positives = 243/611 (39%), Gaps = 85/611 (13%)
Query: 61 AKVPERKLQANGPVAKKAK--KKASSSDSEDSSEEEEEVQGPPAKKA-AVPAKRVGLPPG 117
A+V E++ P A K K KK + ED EE+E+ + AKK P K+ P
Sbjct: 618 AEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKK 677
Query: 118 KAAAKASESSSSEESSDDDDEEDQKKQP---VQKGVKPQ-----AKAAKAPPKKAKSSDS 169
+ K + +E + +E +K+ P V+K VK + K K P K+ K
Sbjct: 678 EEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPK 737
Query: 170 DSDSS----SEDEPPKNQKPKI--TPVTVKAQTKAPPKPARAAPKI----ANGKAA---S 216
D+ S SE + P KPK+ +VK + A KP + KI GKAA +
Sbjct: 738 DAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKP-KEKGKIKVIKKEGKAAEAVA 796
Query: 217 SSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAP---------VKAATTPTRKSSSS 267
++ + +++++ + AA P K + ++ + +P +KA K
Sbjct: 797 AAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKP 856
Query: 268 EDSSSDEEEEQK-----------KPMKNKPGPYSS--------------VPPPSAPPPKK 302
+ ++EE+ K K + GP S P P +
Sbjct: 857 QLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVE 916
Query: 303 SLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTK-----AVVSKATTKPPPAKK 357
G +K ++ E S ++ D + + EE + P + VS + P ++
Sbjct: 917 KQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEE 976
Query: 358 AAESSSD----------SSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPK 407
+A++ +D +S D +E+D + G + S + K+ +
Sbjct: 977 SAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEP 1036
Query: 408 QPVGGGQKLL--TRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQG 465
+ + ++ KA + EE TK++ A + + + A S+ + P G
Sbjct: 1037 EKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGR---EPASSIHDETLPGG 1093
Query: 466 SRDSSSDSDSSSSEEE-EEKTSKSAVKKKPQKVAGGAAPSKPASAKKG-KAESSNSSSSD 523
S ++ SD + E++ EE T+ S + +++ P S + ++ +N+ ++
Sbjct: 1094 SESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETE 1153
Query: 524 DSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNG--KAAKNSEEEEEEKKKAAVVVSKSG 581
S+E K + S Q + + + +T NG + +K + ++ +A +S
Sbjct: 1154 SPSQEFVNITKYESSLYSQ--EYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPS 1211
Query: 582 SLKKRKQNEAA 592
S+++ K + +A
Sbjct: 1212 SMEEDKFSRSA 1222
Score = 58.2 bits (139), Expect = 3e-08
Identities = 127/631 (20%), Positives = 250/631 (39%), Gaps = 81/631 (12%)
Query: 79 KKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDE 138
++KA + ++E+ E+ EE A K + P + +A A E S S DD E
Sbjct: 943 EEKAETEEAEEPEEDGEEHVCVSASKHS-PTEDEESAKAEADAYIREKRESVASGDDRAE 1001
Query: 139 EDQKKQPVQKGVKPQ-------------AKAAKAPPKKAKSSD---SDSDSSSEDEPPKN 182
ED + ++KG Q A+ + P+K ++ D + D ++E +
Sbjct: 1002 EDMD-EAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEE 1060
Query: 183 QKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKT 242
Q +T T + ++P + ++ S S +++S + + + E+ AT T
Sbjct: 1061 QYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYT 1120
Query: 243 VPKKQVVAK-APVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPP--SAPP 299
++ ++ P+ +TP + S++++++E E + N SS+ S P
Sbjct: 1121 QSTIEISSEPTPMDEMSTP--RDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPA 1178
Query: 300 PKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAA 359
L + + + +S S SS EE K A+ ++ A
Sbjct: 1179 DVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVK-----A 1233
Query: 360 ESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSP----AVKPAAAPKQPVGGGQK 415
++ D DS S+ E S P+ + S + P+ K+P +V + P + +
Sbjct: 1234 STTLDIKDSISAVSSEKVS-PSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEA 1292
Query: 416 LLTRKADSSSSE--EESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDS 473
+ + + E EE +S E+KT ++V+ ++ + +A P Q+P + S +
Sbjct: 1293 EVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQ--SVTGSAGHTPYYQSPTDEKSSHLPT 1350
Query: 474 DS-------------SSSEEEEEKTSKSAV------KKKPQKVAGGAAPSKPASAKKGKA 514
+ S +++E E+ S S + + P + S P +
Sbjct: 1351 EVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAY 1410
Query: 515 ES----SNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSE-----E 565
ES + +S + EEK +GSP +P + TS Q+ + K+++ E
Sbjct: 1411 ESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKE 1470
Query: 566 EEEEKKKAAVVVSKSG----SLKKRKQNEAA-KEAETPQAKKIKLQTPNTFPKRKKGEKR 620
+ ++KK V + S +L +RK + + + + Q K T + + +K
Sbjct: 1471 DFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKS 1530
Query: 621 ASSPFRRVREEEIEVDSRVADNSFDAKRGAA 651
A+ VD VA++++ G A
Sbjct: 1531 AT-----------PVDEGVAEDTYSHMEGVA 1550
Score = 57.0 bits (136), Expect = 6e-08
Identities = 63/271 (23%), Positives = 109/271 (40%), Gaps = 12/271 (4%)
Query: 314 EKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKK-AAESSSDSSDSDSSE 372
EK+ P E+ +D D SS E K P T+ +S + P P + A+E ++ S+ ++
Sbjct: 2069 EKKSPSEARQDV-DLCLVSSCEYKHPKTE--LSPSFINPNPLEWFASEEPTEESEKPLTQ 2125
Query: 373 DDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSS-SSEEESS 431
AP P G + T P+ ++ + AD++ SE+ES
Sbjct: 2126 SGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESE 2185
Query: 432 SSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVK 491
+ +KT P A + +P+ S D ++ + E+ K K +K
Sbjct: 2186 TIPTDKTVTYKHMDPPPAPVQ-----DRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLK 2240
Query: 492 KKPQKVAGGAAPSKPASAKK--GKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGT 549
+K + G + KK GK++ +S +E +K+ SP+ +
Sbjct: 2241 EKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAA 2300
Query: 550 SALTAQNGKAAKNSEEEEEEKKKAAVVVSKS 580
T KAA+ E+++E K A SKS
Sbjct: 2301 KPTTTPEVKAARGEEKDKETKNAANASASKS 2331
Score = 56.2 bits (134), Expect = 1e-07
Identities = 101/501 (20%), Positives = 176/501 (35%), Gaps = 40/501 (7%)
Query: 78 AKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDD 137
A KAS +E EE+ QG P + + V + E S++ + +D
Sbjct: 1416 ADDKASGRGAESPFEEKSGKQGSPDQVSPVSE----MTSTSLYQDKQEGKSTDFAPIKED 1471
Query: 138 EEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTK 197
+KK + + Q A K S + D S ++ K I+ TV ++
Sbjct: 1472 FGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSA 1531
Query: 198 APPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAA 257
P A ++ + +S S++S ++SS T P +P
Sbjct: 1532 TPVDEGVAEDTYSHMEGVASVSTASVATSSFPEP------TTDDVSPSLHAEVGSPHSTE 1585
Query: 258 TTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQ 317
+ S + ++ +E E + P P S PP +P KS ++ +
Sbjct: 1586 VDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSM 1645
Query: 318 PVESSEDSSDES---DSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDD 374
+E ++S ++S D S + P A V T P + S SD DS S
Sbjct: 1646 SIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGP--TEVDYSPSDMQDSSLSHKI 1703
Query: 375 EAPSKPAGTTKNSSNKPAVTTK---SPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESS 431
+P+ T N ++ ++ SP+ A P Q +S +E +
Sbjct: 1704 PPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQ--------------IASPLQEDT 1749
Query: 432 SSEEEKTKKMVATTKPKATAKAALSLPA-KQAPQGSRDSSSDSDSSSSEEEEEKTSKSAV 490
S+ + M + T++ SL K +P+ + +SS S SAV
Sbjct: 1750 LSDVAPPRDM--SLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPTFSDSTSAV 1807
Query: 491 KKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEE---EEKLKGKGSPRPQAPKAN 547
K+K ++P P A + +S D+ + L G + K
Sbjct: 1808 KEKTATCHSSSSP--PIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGKTP 1865
Query: 548 GTSALTAQNGKAAKNSEEEEE 568
G + Q + S +EE+
Sbjct: 1866 GDFSYAYQKPEETTRSPDEED 1886
Score = 41.6 bits (96), Expect = 0.003
Identities = 64/294 (21%), Positives = 100/294 (34%), Gaps = 61/294 (20%)
Query: 158 KAPPKKAKSSDSDSDSSSEDEPPKNQKPK--ITPVTVKAQTKAPPKPARAAPKIANGKAA 215
K+P + + D SS E + PK + I P ++ P P +G A
Sbjct: 2071 KSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAP 2130
Query: 216 SSSSSSSSSSSSDDSEEEKAAATPKKTVPKK---QVVAKAPVKAATTPTRKSSSSEDSSS 272
D+ TP +V + Q + P + P S + D++
Sbjct: 2131 PPPGGKQQGRQCDE--------TPPTSVSESAPSQTDSDVPPETEECP----SITADANI 2178
Query: 273 DEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPK----------------KAVEKQ 316
D E+E + +K Y + PP AP +S + P KA++K
Sbjct: 2179 DSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKD 2238
Query: 317 QPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEA 376
++ SS KK K+ A+ KP K++++ S + E E
Sbjct: 2239 LKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEK 2298
Query: 377 PSKPAGT--------------TKNSSNKPA--------------VTTKSPAVKP 402
+KP T TKN++N A TTKS AV P
Sbjct: 2299 AAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVPP 2352
Score = 35.8 bits (81), Expect = 0.14
Identities = 49/216 (22%), Positives = 79/216 (36%), Gaps = 20/216 (9%)
Query: 77 KAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDD 136
KA KK ++ + P KK+ +K + P A K S S +S
Sbjct: 2233 KALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASP-- 2290
Query: 137 DEEDQKKQPVQKGVKP----QAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTV 192
+KK+ V+K KP + KAA+ K ++ ++ + S+S+ P T T
Sbjct: 2291 ----KKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTK-TT 2345
Query: 193 KAQTKAPPKPARA----APKIANGKAAS-SSSSSSSSSSSDDSEEEKAAATPKKTVPKKQ 247
K+ P P P +N K SS S + AA P + V
Sbjct: 2346 KSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGNDPAAEEPSRAVLDAL 2405
Query: 248 VVAKAP----VKAATTPTRKSSSSEDSSSDEEEEQK 279
+ KA ++ PT S + + E+Q+
Sbjct: 2406 LEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQ 2441
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 86.7 bits (213), Expect = 7e-17
Identities = 127/565 (22%), Positives = 216/565 (38%), Gaps = 78/565 (13%)
Query: 87 SEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPV 146
S+ S EE ++ AAV ++ GLP G A+ES S E D P
Sbjct: 46 SQLSEEERRQI-------AAVMSRAQGLPKGSVPPAAAESPSMHRK----QELDSSHPPK 94
Query: 147 QKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQ-----KPKITPVTVKAQTKAPPK 201
Q G +P A P +KS +D+ S + P ++ K + +K + K+
Sbjct: 95 QSG-RPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMM 153
Query: 202 PARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQV-----VAKAPV-K 255
P + A +S + + DSE + T K+ V +K+ + K P+ +
Sbjct: 154 PGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQ 213
Query: 256 AATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPP---PKKSLGTQPPKKA 312
P K ++ K +P S PP + P P ++ T K
Sbjct: 214 QPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLP 273
Query: 313 VEKQQPVESSEDSSDESDSSSEEEKKP----PTKAVVSKATTKPPPAKKAAESSSDSSDS 368
+++ ++S + ++D E KP P+K + + T PPA++ S +
Sbjct: 274 LQR----DASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPA 329
Query: 369 DSSEDDEAPSKPAGTTKNSSNKPAV---------TTKSPA--VKPAAAPKQPVGG----- 412
+ P++P+G TK + +P TTK PA + PA P Q G
Sbjct: 330 ------KPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSS 383
Query: 413 ---GQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDS 469
G K L + + + + T++ V T KP A + L PAK AP ++
Sbjct: 384 EQPGPKALAQPPGVGKTPAQQPGPAKPPTQQ-VGTPKPLA-QQPGLQSPAK-APGPTKTP 440
Query: 470 SSDSDSSSSEEEEEKTSKSAVK-----KKPQKVAGGAAPSK----PASAKKGKAESSNSS 520
++ K++ + K P ++ G A P PA + S+
Sbjct: 441 VQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPP 500
Query: 521 SSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAA----VV 576
S S + + G P PQ P G++ +Q +AK S ++ K +A
Sbjct: 501 SQQPGSTKPPPQQPGPAKPSPQQP---GSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKP 557
Query: 577 VSKSGSLKKRKQNEAAKEAETPQAK 601
VS++GS K + + A+ P ++
Sbjct: 558 VSQTGSGKPLQPPTVSPSAKQPPSQ 582
Score = 73.9 bits (180), Expect = 5e-13
Identities = 128/605 (21%), Positives = 227/605 (37%), Gaps = 90/605 (14%)
Query: 73 PVAKKAKKKASSSDSEDSSEE---------EEEVQGPPAKKAAVPAKRVGLPPGKAAAKA 123
P KK +A +S E+ + EE+++G A K K+ P K
Sbjct: 1243 PEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQ---PQTKMEGLP 1299
Query: 124 SESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQ 183
S + S DD + K+QP Q + + +K + D SD+SS +P Q
Sbjct: 1300 SGTPQSLPKEDDKTTKTIKEQP-QPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQ 1358
Query: 184 KPKITPVTVKAQTKAPPKPARAAPK----IANGKAASSSSSSSSSSSSDDSEE------- 232
T + + + + P I G S S SS SS D +
Sbjct: 1359 GLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLS 1418
Query: 233 --EKAAAT------PKKTVPKKQVVAKAPVKAATTP----TRKSSSSEDSSSDEEEEQKK 280
E A+T KKT P +V + P T T + + SE+ + +EE+K
Sbjct: 1419 ILEAQASTLADEKSEKKTQPH-EVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKD 1477
Query: 281 PMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPP 340
K S PS+ K+ ++ +++P +S E+SS+ +S + K+
Sbjct: 1478 TFKKD----SQQDIPSSKDHKEK--SEFVDDITTRREPYDSVEESSESENSPVPQRKRRT 1531
Query: 341 TKAVVSKATTKPPPAKKAAESS----------SDSSDSDSSEDDEAPSKPAGTTKNSSNK 390
+ S K ++ + E S D+ SEDDE +N +
Sbjct: 1532 SVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEF-------IRNQLKE 1584
Query: 391 PAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESS------------------- 431
+ +T+S + + G + LTRK+ +S E+
Sbjct: 1585 ISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELK 1644
Query: 432 --SSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSA 489
++ ++++++V T + L + A + S +SS S +EE E +S
Sbjct: 1645 YRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESL 1704
Query: 490 VKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQA-PKANG 548
+ G + S AS+ ++ SS D+ S+ KG+ + +A + +G
Sbjct: 1705 TDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHG 1764
Query: 549 TSALTAQNGKAAKNSEEEEE-----EKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKI 603
T ++ + EEEE EK++ + S KK K++ K+ Q ++
Sbjct: 1765 PLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSSKKSKKD---KDELRAQRRRE 1821
Query: 604 KLQTP 608
+ +TP
Sbjct: 1822 RPKTP 1826
Score = 70.9 bits (172), Expect = 4e-12
Identities = 135/594 (22%), Positives = 206/594 (34%), Gaps = 88/594 (14%)
Query: 69 QANGPVAKKAKKKASSSDSEDSSEEEEEVQGP-----PAKK---AAVPAKRVGLPPGKAA 120
Q GP A++ S S + + Q P PA++ A P ++VG P A
Sbjct: 364 QPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQ 423
Query: 121 AKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPP 180
+S + K PVQ Q K P ++A + + + +PP
Sbjct: 424 QPGLQSPAKAPGPT--------KTPVQ-----QPGPGKIPAQQAGPGKTSAQQTGPTKPP 470
Query: 181 KNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK 240
+Q P P Q P KP P + K S S+ + + P
Sbjct: 471 -SQLPG--PAKPPPQQPGPAKPPPQQP--GSAKPPSQQPGSTKPPPQQPGPAKPSPQQPG 525
Query: 241 KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPP 300
T P Q A A K S+ + + + KP++ S+ PPS P
Sbjct: 526 STKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLP 585
Query: 301 K--------KSLGTQPPKKA-----VEKQQPVESSEDSSDESDSSSEEE-------KKPP 340
K L P+KA E Q V S + + +E K
Sbjct: 586 KTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRA 645
Query: 341 TKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDE--APSKPAGTTKNSSNKPAVTTKSP 398
++ + P P K A ++ S+ S SS + +P K A ++ S P P
Sbjct: 646 LGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPP 705
Query: 399 AVK-------PAAAPKQP--VGGGQKLLTRKADSSSSEEESSSSEEEKTK--KMV----- 442
VK P+A KQP K K S SE++ + ++K K KMV
Sbjct: 706 LVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTD 765
Query: 443 ------ATTKPK-ATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQ 495
ATTKP ++K K P DS+ S S E+ S +P
Sbjct: 766 LVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRP- 824
Query: 496 KVAGGAAPSKPASAKKGKAESSNSSSSDD-SSEEEEEKLKGKGSPRPQA-------PKAN 547
A+ SK S +ES D +EE +K + K SP+P A P
Sbjct: 825 -----ASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPP 879
Query: 548 GTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAK 601
G Q + S + +E+ ++ ++ GS+ +++ ET K
Sbjct: 880 GPRPTAGQTVPTPQQSPKPQEQSRRFSL---NLGSITDAPKSQPTTPQETVTGK 930
Score = 69.7 bits (169), Expect = 9e-12
Identities = 114/569 (20%), Positives = 199/569 (34%), Gaps = 47/569 (8%)
Query: 71 NGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSE 130
+GP A + A S + Q PPA ++P K+ P AA+ E + +
Sbjct: 958 SGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAP---AAEKLEPKAEQ 1014
Query: 131 ESSDDDDEEDQKKQPVQ--KGVKPQAKAAKAPPKKAKSSDSDS---------DSSSEDEP 179
+ E ++K P++ K + + + A P K KS +S + S+D P
Sbjct: 1015 APTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPP 1074
Query: 180 PKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATP 239
N T + P +I + + + S D + A +
Sbjct: 1075 NFNT---CTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSG 1131
Query: 240 KKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPP 299
K P + K A P K ++ E E+ K K PP
Sbjct: 1132 PKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTT 1191
Query: 300 PKKSLGTQPPK---KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAK 356
+K ++ K A+++++P+ + E + EEKKP + KP P
Sbjct: 1192 DQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEE------KKPTPED 1245
Query: 357 KAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKL 416
K + +S + + D S+ V ++ APK G Q
Sbjct: 1246 KKLLPEAKTSAPEEQKHDLLKSQ-------------VQIAEEKLEGRVAPKTVQEGKQPQ 1292
Query: 417 LTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSS 476
+ S + + +++ TK + +P TAK P K+ + D SD+ SS
Sbjct: 1293 TKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTE-KEDDKSDTSSS 1351
Query: 477 SSEEEEEKTSKSAVKKKPQKVAGGAAPSK-PASAK---KGKAESSNSSSSDDSSEEEEEK 532
+ + S + + G PS P K KG + S S S SS + K
Sbjct: 1352 QQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAK 1411
Query: 533 LKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAA 592
L+ S +A ++ ++ K + E E+ K S S +L+ E
Sbjct: 1412 LE---STVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEI 1468
Query: 593 KEAETPQAKKIKLQTPNTFPKRKKGEKRA 621
KE++ + K + P K ++++
Sbjct: 1469 KESQEERKDTFKKDSQQDIPSSKDHKEKS 1497
Score = 68.2 bits (165), Expect = 3e-11
Identities = 144/665 (21%), Positives = 233/665 (35%), Gaps = 113/665 (16%)
Query: 61 AKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAA 120
AK P +++ P+A++ S ++ + VQ P K +PA++ G PGK +
Sbjct: 408 AKPPTQQVGTPKPLAQQP---GLQSPAKAPGPTKTPVQQPGPGK--IPAQQAG--PGKTS 460
Query: 121 AKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPP 180
A+ + + K P Q G AK PP++ S+ S +PP
Sbjct: 461 AQQTGPTKPPSQLPGP----AKPPPQQPG------PAKPPPQQPGSAKPPSQQPGSTKPP 510
Query: 181 KNQKPKITPVTVKAQTKAPP-------KPARAAPKIANGKAASSSSSSSSSSS------- 226
Q P + + PP KP+ P A A S+ S + S
Sbjct: 511 PQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPP 570
Query: 227 --SDDSEEEKAAATPKKTVP---KKQVVAKAPVKA--------ATTPTRKSSSSEDSSSD 273
S +++ + PK P +++ P KA TT + +
Sbjct: 571 TVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLT 630
Query: 274 EEEEQ---KKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQP----VESSEDSS 326
E +E MK G P PS+P PK AV K P +D++
Sbjct: 631 EVKEWLCLNCQMKRALGG-DLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAA 689
Query: 327 DESD-SSSEEEKKPPT-------KAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAP- 377
+ D S + E KKPP S +PP A ++ + S SE D+AP
Sbjct: 690 PKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPV 749
Query: 378 --SKPAG-----------TTKNSSNKPAV-----------TTKSPAVKPAAAPKQ---PV 410
KP ++ +++ KP + T P +A P Q P
Sbjct: 750 ADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPT 809
Query: 411 GG-----GQKLLTRKADSSSSEEESSSSEEEKTKKMVATTK-----PKATAKAALSLPAK 460
G K + R A S S E K +K V + KA K + AK
Sbjct: 810 GEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAK 869
Query: 461 QAPQGS------RDSSSDS--DSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKG 512
P+GS R ++ + S + +E++ + ++ A + P+ P G
Sbjct: 870 PMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTG 929
Query: 513 KAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKK 572
K +S +S + G P P + G A S+ + +
Sbjct: 930 KLFGFGASIFSQAS----NLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQ 985
Query: 573 AAVVVSKSGSLKKRKQNEAAK--EAETPQAKKIK-LQTPNTFPKRKKGEKRASSPFRRVR 629
A +KS +KK + AA+ E + QA +K +T P K + + P + V
Sbjct: 986 APPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVL 1045
Query: 630 EEEIE 634
++E
Sbjct: 1046 PTKLE 1050
Score = 65.1 bits (157), Expect = 2e-10
Identities = 122/631 (19%), Positives = 214/631 (33%), Gaps = 82/631 (12%)
Query: 59 KSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGK 118
KS+ P++ K+ KA ++ + G P+ KA P + L
Sbjct: 674 KSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPA 733
Query: 119 AAAKASESSSSEESSDDDDEEDQKKQ-------------------PVQKGVKPQAKAAKA 159
+ S S +++ DD+ Q K P K V+ QA+
Sbjct: 734 PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSK-VQSQAEEKTT 792
Query: 160 PPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSS 219
PP K +DS S+ PP + K++P +KA P+PA + I++ +S S
Sbjct: 793 PPLK-----TDSAKPSQSFPPTGE--KVSPF----DSKAIPRPASDSKIISHPGPSSESK 841
Query: 220 SSSSSSSSDDSEEEKAAATPKKTVPKKQVVAK-APVKAATTPTRKSSSSEDSSSDEEEEQ 278
EE K A T P + + K +P PT + S + +EQ
Sbjct: 842 GQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQ 901
Query: 279 KKPMKNKPGPYSSVPPPSAPPPKKSL---------------------------GTQPPKK 311
+ G + P P++++ +Q
Sbjct: 902 SRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPG 961
Query: 312 AVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSS 371
A KQ P S +S S+ + P K++ K TK P A+K + + +
Sbjct: 962 APMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRT 1021
Query: 372 EDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESS 431
E ++ P P +K+ + +P AV P K P L + + S++ +
Sbjct: 1022 ETEKKP-PPIKDSKSLTAEP-----QKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPN 1075
Query: 432 SSEEEKTKKMVA-----TTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTS 486
+ + K V P T Q + D K S
Sbjct: 1076 FNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKAS 1135
Query: 487 KSAV--KKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAP 544
V + QK A P + KK + E + + +E K P
Sbjct: 1136 PMPVPTESSSQKT---AVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTD 1192
Query: 545 KANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAE-TPQAKKI 603
+ S L A + + EEKK ++ + ++ ++ +E + TP+ KK+
Sbjct: 1193 QKQEESKLEKDKASALQEKKPLPEEKK----LIPEEEKIRSEEKKPLLEEKKPTPEDKKL 1248
Query: 604 KLQTPNTFPKRKKGEKRASSPFRRVREEEIE 634
+ + P+ +K + S ++ EE++E
Sbjct: 1249 LPEAKTSAPEEQKHDLLKSQV--QIAEEKLE 1277
Score = 58.2 bits (139), Expect = 3e-08
Identities = 109/586 (18%), Positives = 206/586 (35%), Gaps = 92/586 (15%)
Query: 63 VPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAK 122
+P K+Q+ +A++K + DS++ + K + +K + P +
Sbjct: 778 IPSSKVQS------QAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKII 831
Query: 123 ASESSSSEESSDDDDEEDQKKQPVQKG---------VKPQAKAAKAPPKKAKSSDSDSDS 173
+ SSE + QKK+ +K KP K + PP ++ +
Sbjct: 832 SHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPT 891
Query: 174 SSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAA-------SSSSSSSSSSS 226
+ P+ Q + + + + + T AP + GK S +S+ S++
Sbjct: 892 PQQSPKPQEQSRRFS-LNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAG 950
Query: 227 SDDSEEEKAAATPKKTVPK-----------KQVVAKAPVKAATTPTRKSSSSEDSSSDEE 275
+ P K P K P A + P +K + + + E
Sbjct: 951 QPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEP 1010
Query: 276 EEQKKPM------KNKPGPYSSVPPPSAPPPKKSLGTQPPKK-AVEKQQPVESSEDSSDE 328
+ ++ P + KP P +A P K L T+ K E P+ +E +
Sbjct: 1011 KAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGS 1070
Query: 329 SDSSSEEEKKPPTKAVVSKATTKPPP----------AKKAAESSSDSSDSDSSEDDEAPS 378
D + V + P P + + D + APS
Sbjct: 1071 KDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPS 1130
Query: 379 KPAGT-----TKNSSNKPAVTTKSPAVKPAAAPKQPV-GGGQKLL--------------- 417
P + T++SS K AV P VK +Q V +K++
Sbjct: 1131 GPKASPMPVPTESSSQKTAV---PPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPP 1187
Query: 418 ----TRKADSSSSEEESSSSEEEK-----TKKMVATTKPKATAKAALSLPAKQAPQGSRD 468
+K + S E++ +S+ +EK KK++ + + + L K+ +
Sbjct: 1188 MVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKK 1247
Query: 469 SSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSN-SSSSDDSSE 527
++ +S+ EE++ KS V+ +K+ G AP K+ + + S + S
Sbjct: 1248 LLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLP 1307
Query: 528 EEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKA 573
+E++K +PQ P TA+ + E+ E+E K+
Sbjct: 1308 KEDDKTTKTIKEQPQPP-------CTAKPDQVEPGKEKTEKEDDKS 1346
Score = 42.7 bits (99), Expect = 0.001
Identities = 66/305 (21%), Positives = 116/305 (38%), Gaps = 28/305 (9%)
Query: 313 VEKQQPVESSEDSSDESDSSSEEEKKPPT----KAVVSKATTKPPPAKKAAESSSDSSDS 368
V +++ + S D+S ++D ++E PT KA V K A K S SS +
Sbjct: 3458 VSRRRRTKKSVDTSVQTDDEDQDEWDMPTRSRRKARVGKYGDSMTEADKTKPLSKVSSIA 3517
Query: 369 -DSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADS-SSS 426
+ + ++P GT + S + V K +K +AP++ GG +ADS + S
Sbjct: 3518 VQTVAEISVQTEPVGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTEADSDTQS 3577
Query: 427 EEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTS 486
+ S++ K KK + ++ + AP + S S S K
Sbjct: 3578 PQYLSATSPPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPK-SPKVLYSPISPLSPGKAL 3636
Query: 487 KSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKA 546
+SA + + +P K K + S + + + P+P +P A
Sbjct: 3637 ESAFVPYEKPLPDDISPQKVLHPDMAKVPPA-------SPKTAKMMQRSMSDPKPLSPTA 3689
Query: 547 NGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQ 606
+ +S Q E K + ++ SG+ KK K + P ++I
Sbjct: 3690 DESSRAPFQ---------YTEGYTTKGSQTMTSSGAQKKVK-----RTLPNPPPEEISTG 3735
Query: 607 TPNTF 611
T +TF
Sbjct: 3736 TQSTF 3740
Score = 42.0 bits (97), Expect = 0.002
Identities = 81/327 (24%), Positives = 119/327 (36%), Gaps = 37/327 (11%)
Query: 88 EDSSEEEEEVQGPPA-----KKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQK 142
EDS E P + ++ +V R P G+A+A S S+ +S + K
Sbjct: 2221 EDSEEISSSTYFPGSIIDYPEEISVSLDRTAPPDGRASADHIVISLSDMASSIIESVVPK 2280
Query: 143 KQ-PVQKGVKPQAKAA-KAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKA-- 198
+ PV V + K P KKAK + E +++K T + ++
Sbjct: 2281 PEGPVADTVSTDLLISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETVF 2340
Query: 199 --PPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKA 256
PP A P S++ +S + +EK A+ P V+ P K
Sbjct: 2341 DHPPSSVIALPM-------KEQLSTTYFTSGETFGQEKPASQLPSGSPS---VSSLPAKP 2390
Query: 257 ATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQ 316
P +SSS + S+ P P P PPP PPP T PKK +
Sbjct: 2391 R--PFFRSSSLDISAQPPPPPPPPPPPPPPPP--PPPPPPLPPPTSPKPTILPKKKLTVA 2446
Query: 317 QPVESSEDSSD-----ESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSS 371
PV ++ D E+ + P T+ TT PPP + SS S +
Sbjct: 2447 SPVTTATPLFDAVTTLETTAVLRSNGLPVTRI----CTTAPPPV--PPKPSSIPSGLVFT 2500
Query: 372 EDDEAPSKPAGTTKNSSNKPAVTTKSP 398
E PSKP K + TT+ P
Sbjct: 2501 HRPE-PSKPPIAPKPVIPQLPTTTQKP 2526
Score = 38.5 bits (88), Expect = 0.021
Identities = 52/219 (23%), Positives = 87/219 (39%), Gaps = 30/219 (13%)
Query: 101 PAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAP 160
P+ +A V AK V + +A + + S + D + Q Q + P+ K P
Sbjct: 3537 PSIRARVDAK-VEIIKHISAPEKTYKGGSLGCQTEADSDTQSPQYLSATSPPKDKKRPTP 3595
Query: 161 PKKAKSSDSDSDSSSE--DEPPKNQKPKITPVTVKAQTKA---------PPKPARAAP-K 208
+ SS +DS+ + PPK+ K +P++ + KA P P +P K
Sbjct: 3596 LEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQK 3655
Query: 209 IANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSE 268
+ + A +S ++ +++ + PK P ++AP + T K S +
Sbjct: 3656 VLHPDMAKVPPASPKTAKM----MQRSMSDPKPLSPTADESSRAPFQYTEGYTTKGSQTM 3711
Query: 269 DSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQ 307
SS QKK + P P PP + S GTQ
Sbjct: 3712 TSSG----AQKKVKRTLPNP---------PPEEISTGTQ 3737
Score = 36.2 bits (82), Expect = 0.11
Identities = 51/236 (21%), Positives = 82/236 (34%), Gaps = 17/236 (7%)
Query: 118 KAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSED 177
K + E E S D ED+ + + + P S D DSDSS
Sbjct: 1688 KTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSS--- 1744
Query: 178 EPPKNQKPKITPVTVKAQTKAPPKP-ARAAPKIANGKAASSSSSSSSSSSSDDSEEE--- 233
P ++K + K Q KA +P P I + + + E
Sbjct: 1745 --PSHKKGES-----KQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQ 1797
Query: 234 --KAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSS 291
+ +++ K K ++ A+ + TP S ED+S EE Q M+ S
Sbjct: 1798 QQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCS 1857
Query: 292 VPPPSAPPPKKSLGTQPPK-KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVS 346
PS + P K V+K + ++ +D S +K+ KA+ S
Sbjct: 1858 EYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQKALKS 1913
Score = 30.4 bits (67), Expect = 5.8
Identities = 61/296 (20%), Positives = 103/296 (34%), Gaps = 31/296 (10%)
Query: 170 DSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDD 229
D D++ + ++ K + V QT + P + KA S + +
Sbjct: 3449 DEDATDRSYVSRRRRTKKS-VDTSVQTDDEDQDEWDMPTRSRRKARVGKYGDSMTEADKT 3507
Query: 230 SEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPY 289
K ++ +TV + V + PV TP+ ++ D+ + + P K G
Sbjct: 3508 KPLSKVSSIAVQTVAEISVQTE-PVGTIRTPSIRARV--DAKVEIIKHISAPEKTYKGGS 3564
Query: 290 ---SSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVS 346
+ P+ T PPK ++ P+E S +DS+ + PP V
Sbjct: 3565 LGCQTEADSDTQSPQYLSATSPPKDK-KRPTPLEIGYSSHLRADSTVQLAPSPPKSPKVL 3623
Query: 347 KATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAP 406
+ P KA ES+ + DD +P K P + PA A
Sbjct: 3624 YSPISPLSPGKALESAFVPYEK-PLPDDISPQKVL--------HPDMAKVPPASPKTAKM 3674
Query: 407 KQPVGGGQKLLTRKADSSS--------------SEEESSSSEEEKTKKMVATTKPK 448
Q K L+ AD SS S+ +SS ++K K+ + P+
Sbjct: 3675 MQRSMSDPKPLSPTADESSRAPFQYTEGYTTKGSQTMTSSGAQKKVKRTLPNPPPE 3730
>gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]
Length = 953
Score = 86.3 bits (212), Expect = 9e-17
Identities = 118/523 (22%), Positives = 201/523 (38%), Gaps = 64/523 (12%)
Query: 75 AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSD 134
AK+ +K D + E E+E +G P ++ P R PP K A A+ + + +
Sbjct: 458 AKRDEKDRQHRDRDREKEREKE-KGKPKPRSPQPPSRQAEPPKKEA--ATTGPQVKRADE 514
Query: 135 DDDEEDQKKQPVQK-GVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVK 193
D + K P +K GV A+ K + SS S S+SS +
Sbjct: 515 WKDPWRRSKSPKKKLGVSVSPSRARRRRKTSASSASASNSSRSSS--------------R 560
Query: 194 AQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAP 253
+ + + +R+ + ++ + SS SS SS S S +++P + +P
Sbjct: 561 SSSYSGSGSSRSRSRSSSYSSYSSRSSRHSSFSGSRSRSRSFSSSP----------SPSP 610
Query: 254 VKAATTPT--RKSSSSEDSSSDEEEEQKKPMKNKPGPYSS-----VPPPSAP-PPKKSLG 305
+ P+ K + E+ KKP P ++ VP P+ P P+++
Sbjct: 611 TPSPHRPSIRTKGEPAPPPGKAGEKSVKKPAPPPAPPQATKTTAPVPEPTKPGDPREARR 670
Query: 306 TQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDS 365
+ P + +++ + S S S S S + + + VS + +A SSS S
Sbjct: 671 KERPARTPPRRRTLSGSGSGSGSSYSGSSSRSRSLSVSSVSSVS--------SATSSSSS 722
Query: 366 SDSDSSEDDEAP-SKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSS 424
+ S SED A + P + + S PA T K K G K RK DSS
Sbjct: 723 AHSVDSEDMYADLASPVSSASSRSPAPAQTRKEKG-------KSKKEDGVKEEKRKRDSS 775
Query: 425 SSEEESS-------SSEEEKTKKMVATTKPK-----ATAKAALSLPAKQAPQGSRDSSSD 472
+ +S+ SS++ T + +P+ A + L+L K A +GSR
Sbjct: 776 TQPPKSAKPPAGGKSSQQPSTPQQAPPGQPQQGTFVAHKEIKLTLLNKAADKGSRKRYEP 835
Query: 473 SDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEK 532
SD K ++ + + G P ++ S ++ D + +
Sbjct: 836 SDKDRQSPPPAKRPNTSPDRGSRDRKSGGRLGSPKPERQRGQNSKAPAAPADRKRQLSPQ 895
Query: 533 LKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAV 575
K KA+ A + ++GKA+ S EE K+ AV
Sbjct: 896 SKSSSKVTSVPGKASDPGAASTKSGKASTLSRREELLKQLKAV 938
Score = 71.2 bits (173), Expect = 3e-12
Identities = 79/367 (21%), Positives = 138/367 (37%), Gaps = 23/367 (6%)
Query: 262 RKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPP-SAPPPKKSLGTQPP--KKAVEKQQP 318
R + D E+E++K K KP P S PP A PPKK T P K+A E + P
Sbjct: 460 RDEKDRQHRDRDREKEREKE-KGKPKPRSPQPPSRQAEPPKKEAATTGPQVKRADEWKDP 518
Query: 319 VESSEDSSDE---SDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDE 375
S+ + S S S ++ T A + A+ + +++ S S S
Sbjct: 519 WRRSKSPKKKLGVSVSPSRARRRRKTSASSASASNSSRSSSRSSSYSGSGSSRSRSRSSS 578
Query: 376 APSKPAGTTKNSS-----NKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEES 430
S + ++++SS ++ + SP+ P +P +P + K + + ++
Sbjct: 579 YSSYSSRSSRHSSFSGSRSRSRSFSSSPSPSPTPSPHRPS------IRTKGEPAPPPGKA 632
Query: 431 SSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAV 490
E+ KK P K +P P R++ + + +T +
Sbjct: 633 G---EKSVKKPAPPPAPPQATKTTAPVPEPTKPGDPREARR-KERPARTPPRRRTLSGSG 688
Query: 491 KKKPQKVAGGAAPSKPASAKK-GKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGT 549
+G ++ S+ S S+ SSSS S + E+ SP A +
Sbjct: 689 SGSGSSYSGSSSRSRSLSVSSVSSVSSATSSSSSAHSVDSEDMYADLASPVSSASSRSPA 748
Query: 550 SALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPN 609
A T + +K + +EEK+K S K +++++ TPQ
Sbjct: 749 PAQTRKEKGKSKKEDGVKEEKRKRDSSTQPPKSAKPPAGGKSSQQPSTPQQAPPGQPQQG 808
Query: 610 TFPKRKK 616
TF K+
Sbjct: 809 TFVAHKE 815
Score = 47.0 bits (110), Expect = 6e-05
Identities = 114/598 (19%), Positives = 204/598 (34%), Gaps = 113/598 (18%)
Query: 61 AKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAA 120
A+ PER + P ++ + S D S ++++ G + + + +
Sbjct: 4 AESPER--DPHSPEDEEQPQGLSDDDILRDSGSDQDLDGAGVRASDLEDEE--------- 52
Query: 121 AKASESSSSEESSDDDDEEDQKKQPVQKG----VKPQAKAAKAPPKKAKSSDSDSDSSSE 176
A+ S EE + DEED+ +P + V ++ + P + + + + D +S+
Sbjct: 53 -SAARGPSQEEEDNHSDEEDRASEPKSQDQDSEVNELSRGPTSSPCEEEGDEGEEDRTSD 111
Query: 177 --DEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEK 234
DE + ++ + + P +PA A + KA + + +EEK
Sbjct: 112 LRDEASSVTR-ELDEHELDYDEEVPEEPAPAVQEDEAEKAGA------------EDDEEK 158
Query: 235 AAATPKKT--VPKKQVVAKAPVKAATTPTRKSSSSE------DSSSDEEEEQKKP----- 281
TP++ + V K ++AA ++ E D EE E K P
Sbjct: 159 GEGTPREEGKAGVQSVGEKESLEAAKEKKKEDDDGEIDDGEIDDDDLEEGEVKDPSDRKV 218
Query: 282 ---------MK----------------NKPGPYSSV------PPPSAPPPKKSLGTQPPK 310
MK N G YS + PP APP LG P
Sbjct: 219 RPRPTCRFFMKGNCTWGMNCRFIHPGVNDKGNYSLITKADPFPPNGAPP----LGPHPLM 274
Query: 311 KAVEKQQPVESS---EDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSD 367
A PV + S+ E K V+ KAT + E +
Sbjct: 275 PANPWGGPVVDEILPPPPPEPPTESAWERGLRHAKEVLKKATIRKEQEPDFEEKRFTVT- 333
Query: 368 SDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSE 427
ED+ K ++ +++ + ++P A P E
Sbjct: 334 --IGEDEREFDKENEVFRDWNSRIPRDVRDTVLEPYADPYYDY--------------EIE 377
Query: 428 EESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSK 487
+ E + T+P + ++ Q R+ + D + E+ +
Sbjct: 378 RFWRGGQYENFRVQYTETEPYHNYRERERERERENRQRERERERERDRERERRQRERERE 437
Query: 488 SAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPR-PQAP-- 544
++ ++ + ++ K + + D E+E EK KGK PR PQ P
Sbjct: 438 REHERDKER----QRRKEEWERERAKRDEKDRQHRDRDREKEREKEKGKPKPRSPQPPSR 493
Query: 545 KANGTSALTAQNGKAAKNSEE-------EEEEKKKAAVVVSKSGSLKKRKQNEAAKEA 595
+A A G K ++E + KKK V VS S + ++RK + ++ A
Sbjct: 494 QAEPPKKEAATTGPQVKRADEWKDPWRRSKSPKKKLGVSVSPSRARRRRKTSASSASA 551
Score = 42.4 bits (98), Expect = 0.001
Identities = 63/299 (21%), Positives = 104/299 (34%), Gaps = 27/299 (9%)
Query: 60 SAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKA 119
+A VPE + A++ ++ A + + G ++ ++ + + +
Sbjct: 653 TAPVPEPTKPGDPREARRKERPARTPPRRRTLSGSGSGSGSSYSGSSSRSRSLSVSSVSS 712
Query: 120 AAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDS------DS 173
+ A+ SSSS S D +D PV A+ +K KS D
Sbjct: 713 VSSATSSSSSAHSVDSEDMYADLASPVSSASSRSPAPAQTRKEKGKSKKEDGVKEEKRKR 772
Query: 174 SSEDEPPKNQKP----KITPVTVKAQTKAPPKPAR---AAPKIANGKAASSSSSSSSSSS 226
S +PPK+ KP K + Q P +P + A K + ++ S
Sbjct: 773 DSSTQPPKSAKPPAGGKSSQQPSTPQQAPPGQPQQGTFVAHKEIKLTLLNKAADKGSRKR 832
Query: 227 SDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKP 286
+ S++++ + P AK P + +R S S + E Q+ P
Sbjct: 833 YEPSDKDRQSPPP----------AKRPNTSPDRGSRDRKSGGRLGSPKPERQRGQNSKAP 882
Query: 287 GPYSSVPPPSAPPPKKSLG-TQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAV 344
+ +P K S T P KA P +S S S S EE KAV
Sbjct: 883 AAPADRKRQLSPQSKSSSKVTSVPGKA---SDPGAASTKSGKASTLSRREELLKQLKAV 938
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 85.5 bits (210), Expect = 2e-16
Identities = 131/628 (20%), Positives = 234/628 (37%), Gaps = 95/628 (15%)
Query: 27 LSEVANKFAKA--TGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASS 84
LS++A KF K + T +D S K + ++ V K ++ SS
Sbjct: 923 LSDIAEKFLKKDQSDETSEDDKKQSK--------KGTEEKKKPSDFKKKVIKMEQQYESS 974
Query: 85 SDSEDSSEEEEEVQGPPA-------------KKAAVPAKRVGLPPGKAAAKASESSSSEE 131
SD + E EE+ P KK+ + + + A +S+ +
Sbjct: 975 SDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGD 1034
Query: 132 SSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPK-ITPV 190
S D +++ K + K K+ K+ S SD++ S E N K + +
Sbjct: 1035 SCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRI 1094
Query: 191 TVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVA 250
++ + K R +I +G SSSS + SS D+ ++++ ++ KK V K+
Sbjct: 1095 ELRERRNLSSK--RNTKEIQSG----SSSSDAEESSEDNKKKKQRTSSKKKAVIVKE--K 1146
Query: 251 KAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKS---LGTQ 307
K +T +++ + SSSD E++ + + + P + S
Sbjct: 1147 KRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQS 1206
Query: 308 PPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSD 367
+A+ K PV + +D D++D + KK + + + SSD
Sbjct: 1207 SGDEALSKSVPV-TVDDDDDDNDPENRIAKKMLLEEIKANL----------------SSD 1249
Query: 368 SDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSE 427
D S DDE T K + P V + + R +
Sbjct: 1250 EDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTV 1309
Query: 428 EESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSS---SEEEEEK 484
+ S EE+KTK PK + K + + S DS S SE E+E+
Sbjct: 1310 SDGESGEEKKTK-------PKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQ 1362
Query: 485 TSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAP 544
++ KK + + + ++ K + +SS + +SEEEEE+ + +
Sbjct: 1363 RPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEE-------- 1414
Query: 545 KANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIK 604
+ EEEEEE+++ SKS ++K + K+ K++
Sbjct: 1415 ----------------EEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKD------DKLR 1452
Query: 605 LQTPNTFPKRKKGEKRASSPFRRVREEE 632
+T N + ++ KR + R RE E
Sbjct: 1453 TETQNALKEEEERRKRIA---ERERERE 1477
Score = 81.6 bits (200), Expect = 2e-15
Identities = 146/625 (23%), Positives = 238/625 (38%), Gaps = 92/625 (14%)
Query: 65 ERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKAS 124
+ K + + PV KK K+ +SSDS + + ++ P +K++ + A K
Sbjct: 648 KEKQKLSVPVRKKDKR--NSSDSAIDNPKPNKL--PKSKQSETVDQNSDSDEMLAILKEV 703
Query: 125 ESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQK 184
S SSD D E +K QA +K KSS S SD ++ K +
Sbjct: 704 SRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTK----KGKS 759
Query: 185 PKITPVT-VKAQTKAPPK-----------------PARAAPK-IANGKAASSSS------ 219
K + ++ K QT++ AR K I N K SS
Sbjct: 760 AKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSK 819
Query: 220 -----------SSSSSSSSDDSE---EEKAAATPKKTVPKKQVV--------AKAPVKAA 257
+S SSDD+E E + ++ + TV K + K A+
Sbjct: 820 KGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASAS 879
Query: 258 TTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQ 317
T K S E S + E + K K + + +K ++K Q
Sbjct: 880 TDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIA----EKFLKKDQ 935
Query: 318 PVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAP 377
E+SED +S +EE+KKP S K ++ ESSSD ++ E +E
Sbjct: 936 SDETSEDDKKQSKKGTEEKKKP------SDFKKKVIKMEQQYESSSDGTEK-LPEREEIC 988
Query: 378 SKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEK 437
P G + + KS ++ + K+ L+ A+ S+ + +S S E+K
Sbjct: 989 HFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDE------LSDYAEKSTGKGDSCDSSEDK 1042
Query: 438 TKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKV 497
K A + K K L K + + SSSD++ S +E+ +S +K+ +
Sbjct: 1043 KSKNGAYGREKKRCK----LLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELR- 1097
Query: 498 AGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNG 557
+ S+K+ E + SSS D+ E E+ K K R + K A+ +
Sbjct: 1098 -----ERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKK--QRTSSKK----KAVIVKEK 1146
Query: 558 KAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKG 617
K +NS ++K+A + S S ++ QN + + Q KIK T N G
Sbjct: 1147 K--RNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQ--KIKPVTENLVLSSHTG 1202
Query: 618 EKRASSPFRRVREEEIEVDSRVADN 642
++S + + VD DN
Sbjct: 1203 FCQSSGDEALSKSVPVTVDDDDDDN 1227
Score = 79.3 bits (194), Expect = 1e-14
Identities = 149/692 (21%), Positives = 267/692 (38%), Gaps = 94/692 (13%)
Query: 25 NQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASS 84
+Q S+ A ++ ++SS DI + + K QA K K+K+S+
Sbjct: 688 DQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSST 747
Query: 85 SDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQ 144
S S+ +++ G AK + + K+ + ESS+ D E
Sbjct: 748 SGSDFDTKK-----GKSAKSSIISKKK--------------RQTQSESSNYDSE------ 782
Query: 145 PVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPAR 204
++K +K +K A K + ++ SSEDE K+ K K K +
Sbjct: 783 -LEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDE--KHSK--------KGMDNQGHKNLK 831
Query: 205 AAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKS 264
+ + ++ A + SS+ +++ + +PKKQ + A+T K
Sbjct: 832 TSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQAS-----ASTDGVDKL 886
Query: 265 SSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSED 324
S E S + E + K K + + +K ++K Q E+SED
Sbjct: 887 SGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIA----EKFLKKDQSDETSED 942
Query: 325 SSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTT 384
+S +EE+KKP S K ++ ESSSD ++ E +E P G
Sbjct: 943 DKKQSKKGTEEKKKP------SDFKKKVIKMEQQYESSSDGTEK-LPEREEICHFPKGIK 995
Query: 385 KNSSNKPAVTTKSPAVKPAAAPKQP-VGGGQKLLTRKADSSSSEEESSSSE-----EEKT 438
+ + KS ++ + K+ + + T K DS S E+ S E+K
Sbjct: 996 QIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKR 1055
Query: 439 KKMVATTKPKA-------TAKAAL---------------------SLPAKQAPQGSRDSS 470
K++ + K T K ++ +L +K+ + + S
Sbjct: 1056 CKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGS 1115
Query: 471 SDSDSS-SSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEE 529
S SD+ SSE+ ++K +++ KKK V S S K+ +A+ ++SSSSD E++
Sbjct: 1116 SSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSD--IEDD 1173
Query: 530 EEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQN 589
++ G+GS Q K T L + S +E K V V +N
Sbjct: 1174 DQNSIGEGSSDEQKIKP-VTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDD-DNDPEN 1231
Query: 590 EAAKE--AETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAK 647
AK+ E +A + ++ + ++G+KR +E + +++ D++
Sbjct: 1232 RIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSE 1291
Query: 648 RGAAGDWGER-ANQVLKFTKGKSFRHEKTKKK 678
+ R L + G+S +KTK K
Sbjct: 1292 ESKKPRYRHRLLRHKLTVSDGESGEEKKTKPK 1323
Score = 48.1 bits (113), Expect = 3e-05
Identities = 113/595 (18%), Positives = 222/595 (37%), Gaps = 87/595 (14%)
Query: 138 EEDQKKQPV--QKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQ 195
++++KK V +K K ++ PKK S+ + + +D + + + V
Sbjct: 254 QQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALIV--- 310
Query: 196 TKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVA----- 250
P + + A K+ A +SS + D+ E +A ++ K V+A
Sbjct: 311 ---PKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIKKA 367
Query: 251 --------KAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSS--VPPPSAPPP 300
+ +A ++ ++ E D + E K KP + A
Sbjct: 368 HLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLS 427
Query: 301 KKSLGTQPPKKAV--EKQQPVESSEDSSDESDSSSEEEKKPPTKA------VVSKATTKP 352
+K + ++ + V E+Q+ +S+ +SD E + +P + +VS ++ P
Sbjct: 428 RKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVP 487
Query: 353 PPAKKAAESSSDSSDS-----DSSEDDEAPSKPAGTTKNSSNKP----------AVTTKS 397
+ E++ + S D S E + + N S+K A TK
Sbjct: 488 EDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKE 547
Query: 398 PAVK--PAAAPKQPVGG-----------GQKL--LTRKADSSSSEEESSSSEE--EKTKK 440
VK P + P+ G G K L K + +E+S +E E
Sbjct: 548 LYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVS 607
Query: 441 MVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSA-VKKKPQKVAG 499
++ + + P ++ P + +S+SD +E +EK S V+KK ++ +
Sbjct: 608 LLLEESDLRRSPRVKTTPLRR-PTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSS 666
Query: 500 GAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKA 559
+A P K K++ S + + S+E LK + + + +S+ +
Sbjct: 667 DSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILK-------EVSRMSHSSSSDTDINEI 719
Query: 560 AKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEK 619
N + + K +A +KRK + + + +T + K K + K+K+ +
Sbjct: 720 HTNHKTLYDLKTQAG---KDDKGKRKRKSSTSGSDFDTKKGKSAK---SSIISKKKRQTQ 773
Query: 620 RASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEK 674
SS + E+EI+ S++ GAA +R F + +H K
Sbjct: 774 SESSNYDSELEKEIKSMSKI---------GAARTTKKRIPNTKDFDSSEDEKHSK 819
Score = 29.6 bits (65), Expect = 9.9
Identities = 20/85 (23%), Positives = 39/85 (45%), Gaps = 1/85 (1%)
Query: 350 TKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQP 409
T PP +++ S S S+ D SK GT+ + +K + +++S KP+ K
Sbjct: 32 TSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKR-KPSIVTKYV 90
Query: 410 VGGGQKLLTRKADSSSSEEESSSSE 434
+K L + + + E+S ++
Sbjct: 91 ESDDEKPLDDETVNEDASNENSEND 115
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 85.5 bits (210), Expect = 2e-16
Identities = 131/628 (20%), Positives = 234/628 (37%), Gaps = 95/628 (15%)
Query: 27 LSEVANKFAKA--TGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASS 84
LS++A KF K + T +D S K + ++ V K ++ SS
Sbjct: 961 LSDIAEKFLKKDQSDETSEDDKKQSK--------KGTEEKKKPSDFKKKVIKMEQQYESS 1012
Query: 85 SDSEDSSEEEEEVQGPPA-------------KKAAVPAKRVGLPPGKAAAKASESSSSEE 131
SD + E EE+ P KK+ + + + A +S+ +
Sbjct: 1013 SDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGD 1072
Query: 132 SSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPK-ITPV 190
S D +++ K + K K+ K+ S SD++ S E N K + +
Sbjct: 1073 SCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRI 1132
Query: 191 TVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVA 250
++ + K R +I +G SSSS + SS D+ ++++ ++ KK V K+
Sbjct: 1133 ELRERRNLSSK--RNTKEIQSG----SSSSDAEESSEDNKKKKQRTSSKKKAVIVKE--K 1184
Query: 251 KAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKS---LGTQ 307
K +T +++ + SSSD E++ + + + P + S
Sbjct: 1185 KRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQS 1244
Query: 308 PPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSD 367
+A+ K PV + +D D++D + KK + + + SSD
Sbjct: 1245 SGDEALSKSVPV-TVDDDDDDNDPENRIAKKMLLEEIKANL----------------SSD 1287
Query: 368 SDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSE 427
D S DDE T K + P V + + R +
Sbjct: 1288 EDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTV 1347
Query: 428 EESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSS---SEEEEEK 484
+ S EE+KTK PK + K + + S DS S SE E+E+
Sbjct: 1348 SDGESGEEKKTK-------PKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQ 1400
Query: 485 TSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAP 544
++ KK + + + ++ K + +SS + +SEEEEE+ + +
Sbjct: 1401 RPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEE-------- 1452
Query: 545 KANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIK 604
+ EEEEEE+++ SKS ++K + K+ K++
Sbjct: 1453 ----------------EEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKD------DKLR 1490
Query: 605 LQTPNTFPKRKKGEKRASSPFRRVREEE 632
+T N + ++ KR + R RE E
Sbjct: 1491 TETQNALKEEEERRKRIA---ERERERE 1515
Score = 81.6 bits (200), Expect = 2e-15
Identities = 146/625 (23%), Positives = 238/625 (38%), Gaps = 92/625 (14%)
Query: 65 ERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKAS 124
+ K + + PV KK K+ +SSDS + + ++ P +K++ + A K
Sbjct: 686 KEKQKLSVPVRKKDKR--NSSDSAIDNPKPNKL--PKSKQSETVDQNSDSDEMLAILKEV 741
Query: 125 ESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQK 184
S SSD D E +K QA +K KSS S SD ++ K +
Sbjct: 742 SRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTK----KGKS 797
Query: 185 PKITPVT-VKAQTKAPPK-----------------PARAAPK-IANGKAASSSS------ 219
K + ++ K QT++ AR K I N K SS
Sbjct: 798 AKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSK 857
Query: 220 -----------SSSSSSSSDDSE---EEKAAATPKKTVPKKQVV--------AKAPVKAA 257
+S SSDD+E E + ++ + TV K + K A+
Sbjct: 858 KGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASAS 917
Query: 258 TTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQ 317
T K S E S + E + K K + + +K ++K Q
Sbjct: 918 TDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIA----EKFLKKDQ 973
Query: 318 PVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAP 377
E+SED +S +EE+KKP S K ++ ESSSD ++ E +E
Sbjct: 974 SDETSEDDKKQSKKGTEEKKKP------SDFKKKVIKMEQQYESSSDGTEK-LPEREEIC 1026
Query: 378 SKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEK 437
P G + + KS ++ + K+ L+ A+ S+ + +S S E+K
Sbjct: 1027 HFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDE------LSDYAEKSTGKGDSCDSSEDK 1080
Query: 438 TKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKV 497
K A + K K L K + + SSSD++ S +E+ +S +K+ +
Sbjct: 1081 KSKNGAYGREKKRCK----LLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELR- 1135
Query: 498 AGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNG 557
+ S+K+ E + SSS D+ E E+ K K R + K A+ +
Sbjct: 1136 -----ERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKK--QRTSSKK----KAVIVKEK 1184
Query: 558 KAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKG 617
K +NS ++K+A + S S ++ QN + + Q KIK T N G
Sbjct: 1185 K--RNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQ--KIKPVTENLVLSSHTG 1240
Query: 618 EKRASSPFRRVREEEIEVDSRVADN 642
++S + + VD DN
Sbjct: 1241 FCQSSGDEALSKSVPVTVDDDDDDN 1265
Score = 79.3 bits (194), Expect = 1e-14
Identities = 149/692 (21%), Positives = 267/692 (38%), Gaps = 94/692 (13%)
Query: 25 NQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASS 84
+Q S+ A ++ ++SS DI + + K QA K K+K+S+
Sbjct: 726 DQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSST 785
Query: 85 SDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQ 144
S S+ +++ G AK + + K+ + ESS+ D E
Sbjct: 786 SGSDFDTKK-----GKSAKSSIISKKK--------------RQTQSESSNYDSE------ 820
Query: 145 PVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPAR 204
++K +K +K A K + ++ SSEDE K+ K K K +
Sbjct: 821 -LEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDE--KHSK--------KGMDNQGHKNLK 869
Query: 205 AAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKS 264
+ + ++ A + SS+ +++ + +PKKQ + A+T K
Sbjct: 870 TSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQAS-----ASTDGVDKL 924
Query: 265 SSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSED 324
S E S + E + K K + + +K ++K Q E+SED
Sbjct: 925 SGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIA----EKFLKKDQSDETSED 980
Query: 325 SSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTT 384
+S +EE+KKP S K ++ ESSSD ++ E +E P G
Sbjct: 981 DKKQSKKGTEEKKKP------SDFKKKVIKMEQQYESSSDGTEK-LPEREEICHFPKGIK 1033
Query: 385 KNSSNKPAVTTKSPAVKPAAAPKQP-VGGGQKLLTRKADSSSSEEESSSSE-----EEKT 438
+ + KS ++ + K+ + + T K DS S E+ S E+K
Sbjct: 1034 QIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKR 1093
Query: 439 KKMVATTKPKA-------TAKAAL---------------------SLPAKQAPQGSRDSS 470
K++ + K T K ++ +L +K+ + + S
Sbjct: 1094 CKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGS 1153
Query: 471 SDSDSS-SSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEE 529
S SD+ SSE+ ++K +++ KKK V S S K+ +A+ ++SSSSD E++
Sbjct: 1154 SSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSD--IEDD 1211
Query: 530 EEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQN 589
++ G+GS Q K T L + S +E K V V +N
Sbjct: 1212 DQNSIGEGSSDEQKIKP-VTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDD-DNDPEN 1269
Query: 590 EAAKE--AETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAK 647
AK+ E +A + ++ + ++G+KR +E + +++ D++
Sbjct: 1270 RIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSE 1329
Query: 648 RGAAGDWGER-ANQVLKFTKGKSFRHEKTKKK 678
+ R L + G+S +KTK K
Sbjct: 1330 ESKKPRYRHRLLRHKLTVSDGESGEEKKTKPK 1361
Score = 48.1 bits (113), Expect = 3e-05
Identities = 113/595 (18%), Positives = 222/595 (37%), Gaps = 87/595 (14%)
Query: 138 EEDQKKQPV--QKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQ 195
++++KK V +K K ++ PKK S+ + + +D + + + V
Sbjct: 292 QQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALIV--- 348
Query: 196 TKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVA----- 250
P + + A K+ A +SS + D+ E +A ++ K V+A
Sbjct: 349 ---PKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIKKA 405
Query: 251 --------KAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSS--VPPPSAPPP 300
+ +A ++ ++ E D + E K KP + A
Sbjct: 406 HLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLS 465
Query: 301 KKSLGTQPPKKAV--EKQQPVESSEDSSDESDSSSEEEKKPPTKA------VVSKATTKP 352
+K + ++ + V E+Q+ +S+ +SD E + +P + +VS ++ P
Sbjct: 466 RKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVP 525
Query: 353 PPAKKAAESSSDSSDS-----DSSEDDEAPSKPAGTTKNSSNKP----------AVTTKS 397
+ E++ + S D S E + + N S+K A TK
Sbjct: 526 EDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKE 585
Query: 398 PAVK--PAAAPKQPVGG-----------GQKL--LTRKADSSSSEEESSSSEE--EKTKK 440
VK P + P+ G G K L K + +E+S +E E
Sbjct: 586 LYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVS 645
Query: 441 MVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSA-VKKKPQKVAG 499
++ + + P ++ P + +S+SD +E +EK S V+KK ++ +
Sbjct: 646 LLLEESDLRRSPRVKTTPLRR-PTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSS 704
Query: 500 GAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKA 559
+A P K K++ S + + S+E LK + + + +S+ +
Sbjct: 705 DSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILK-------EVSRMSHSSSSDTDINEI 757
Query: 560 AKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEK 619
N + + K +A +KRK + + + +T + K K + K+K+ +
Sbjct: 758 HTNHKTLYDLKTQAG---KDDKGKRKRKSSTSGSDFDTKKGKSAK---SSIISKKKRQTQ 811
Query: 620 RASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEK 674
SS + E+EI+ S++ GAA +R F + +H K
Sbjct: 812 SESSNYDSELEKEIKSMSKI---------GAARTTKKRIPNTKDFDSSEDEKHSK 857
Score = 29.6 bits (65), Expect = 9.9
Identities = 20/85 (23%), Positives = 39/85 (45%), Gaps = 1/85 (1%)
Query: 350 TKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQP 409
T PP +++ S S S+ D SK GT+ + +K + +++S KP+ K
Sbjct: 32 TSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKR-KPSIVTKYV 90
Query: 410 VGGGQKLLTRKADSSSSEEESSSSE 434
+K L + + + E+S ++
Sbjct: 91 ESDDEKPLDDETVNEDASNENSEND 115
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 85.1 bits (209), Expect = 2e-16
Identities = 126/543 (23%), Positives = 198/543 (36%), Gaps = 99/543 (18%)
Query: 73 PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEE- 131
P AK+ +K S E + P AK K G AA E + ++E
Sbjct: 2298 PSAKRRSRKTSKDTGEGKDGGTAGSEEPGAKARGRGRKPSAKAKGDRAATLEEGNPTDEV 2357
Query: 132 -----SSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEP-PKNQKP 185
+ + KK P + V +AKA KA P + S + +S P P + P
Sbjct: 2358 PSTPLALEPSSTPGSKKSPPEP-VDKRAKAPKARPAPPQPSPAPPAFTSCPAPEPFAELP 2416
Query: 186 KIT------PVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATP 239
P+ T+ PK ARAA EE A P
Sbjct: 2417 APATSLAPAPLITMPATRPKPKKARAA-------------------------EESGAKGP 2451
Query: 240 KKTVPKKQVVAKAPVKAATTPTRKSSSS-----EDSSSDEEEEQKKPMK-NKPGPYSSVP 293
++ + +++ K + T+P K + ED + +E K + P +
Sbjct: 2452 RRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYPPAAGSS 2511
Query: 294 PPSAPPPKKS---LGTQP-PKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKAT 349
P AP PK + L +P P E +S + + E D + E E + + S +
Sbjct: 2512 EPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSS- 2570
Query: 350 TKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQP 409
SSS SS +E +E K + + S A PA++
Sbjct: 2571 -----------SSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSS-- 2617
Query: 410 VGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDS 469
+ SSSS SSSS + +++ +++ ++ S + + S S
Sbjct: 2618 -----------SSSSSSSSSSSSSSSSSS----SSSSSSSSSSSSSSSSSSSSSSSSSSS 2662
Query: 470 SSDSDSSSSEEEEEKTSKSAVKKKPQKVAG----GAAPSKPASAKKGKAESSNSSSSDDS 525
SS S SSSS +E+ + S + P AG A P+K A+ + GKA S S
Sbjct: 2663 SSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPSAQAALPTK-ATKQAGKARPSAHSPG--- 2718
Query: 526 SEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKK 585
K +P+PQAP T L + AK+ KK+ V + + L K
Sbjct: 2719 --------KKTPAPQPQAPPPQPTQPLQPKAQAGAKS-----RPKKREGVHLPTTKELAK 2765
Query: 586 RKQ 588
R++
Sbjct: 2766 RQR 2768
Score = 76.6 bits (187), Expect = 7e-14
Identities = 100/453 (22%), Positives = 161/453 (35%), Gaps = 41/453 (9%)
Query: 116 PGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSS 175
P A S S ++S D E K +P AKA K + + D ++
Sbjct: 2291 PSPALLVPSAKRRSRKTSKDTGEG--KDGGTAGSEEPGAKARGRGRKPSAKAKGDRAATL 2348
Query: 176 EDEPPKNQKPK----ITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSE 231
E+ P ++ P + P + K+PP+P K + A S + + +
Sbjct: 2349 EEGNPTDEVPSTPLALEPSSTPGSKKSPPEPVDKRAKAPKARPAPPQPSPAPPAFTSCPA 2408
Query: 232 EEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSS 291
E A P + AP T P + KP K + S
Sbjct: 2409 PEPFAELPAPAT------SLAPAPLITMPATRP---------------KPKKARAAEESG 2447
Query: 292 VPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTK 351
P P + L + + V + ++ E D + ++P K+++S +
Sbjct: 2448 AKGPRRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEP--KSLLSLGSYP 2505
Query: 352 PPPAKKAAESSSDSSDSDSSEDDEAPSKPA-GTTKNSSNKPAVTTKSPAVKPAAAPKQPV 410
P AA SS + + D + +P G T S P K+ A + A +
Sbjct: 2506 P-----AAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESS 2560
Query: 411 GGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSS 470
+ + SSSS + EEE K +A S ++ A S SS
Sbjct: 2561 SSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAAS--SRAASPASSSSS 2618
Query: 471 SDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEE 530
S S SSSS +S S+ + ++ S +S+ + SS+SSSS + E+
Sbjct: 2619 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSS 2678
Query: 531 EKLKGKGSPRPQAPKANGTSALTAQNGKAAKNS 563
+ +P P A G SA A KA K +
Sbjct: 2679 CSSDDEAAPAPTA----GPSAQAALPTKATKQA 2707
Score = 62.4 bits (150), Expect = 1e-09
Identities = 110/484 (22%), Positives = 168/484 (34%), Gaps = 92/484 (19%)
Query: 35 AKATG---ATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKK-KASSSDSEDS 90
AKA G AT ++ N + + L+ + P K PV K+AK KA + + S
Sbjct: 2338 AKAKGDRAATLEEGNPTDEVPSTPLALEPSSTPGSKKSPPEPVDKRAKAPKARPAPPQPS 2397
Query: 91 SEEEEEVQGP-PAKKAAVPAKRVGLPPG------------KAAAKASESSSSEESSDDDD 137
P P A +PA L P K A A ES + ++
Sbjct: 2398 PAPPAFTSCPAPEPFAELPAPATSLAPAPLITMPATRPKPKKARAAEESGAKGPRRPGEE 2457
Query: 138 EEDQKKQPVQKGVKPQAKAAKAP--------------PKKAKSSDSDSDSSSEDEPPKNQ 183
E K + P++K AK PK S S ++ EP K
Sbjct: 2458 AELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYPPAAGSSEP-KAP 2516
Query: 184 KPKIT----------------------PVTVKAQTKAPPKPARAAPKIANGKAASSSSSS 221
PK T P +A+ + ++ + ++SSSSSS
Sbjct: 2517 WPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSS 2576
Query: 222 SSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKP 281
S S + + E +K T + A A +P SSSS SSS
Sbjct: 2577 SGSETEGEEEGDKNGDGGCGTGGRN---CSAASSRAASPASSSSSSSSSSSSSSSSSSSS 2633
Query: 282 MKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPT 341
+ SS S+ S + SS SS S S+++E+ +
Sbjct: 2634 SSSSSSSSSSSSSSSSSSSSSSSSSS------------SSSSSSSSSSSSTTDEDSSCSS 2681
Query: 342 KAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVK 401
+ A T P A+ A + + +K AG + S++ P K+PA +
Sbjct: 2682 DDEAAPAPTAGPSAQAALPTKA--------------TKQAGKARPSAHSPG--KKTPAPQ 2725
Query: 402 PAAAPKQPVGGGQKLLTRKADSSSSEEES----SSSEEEKTKKMVATTKPKATAKAALSL 457
P A P QP Q A S + E ++ E K +++ + + K A L
Sbjct: 2726 PQAPPPQPTQPLQPKAQAGAKSRPKKREGVHLPTTKELAKRQRLPSV---ENRPKIAAFL 2782
Query: 458 PAKQ 461
PA+Q
Sbjct: 2783 PARQ 2786
Score = 62.0 bits (149), Expect = 2e-09
Identities = 98/472 (20%), Positives = 164/472 (34%), Gaps = 66/472 (13%)
Query: 186 KITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPK 245
++ P K Q A P PA P S+ S +S D+ E K T P
Sbjct: 2278 RLLPPDYKIQC-AEPSPALLVP----------SAKRRSRKTSKDTGEGKDGGTAGSEEPG 2326
Query: 246 KQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLG 305
+ + RK S+ E+ P P ++ P S P KKS
Sbjct: 2327 AKARGRG---------RKPSAKAKGDRAATLEEGNPTDEVPSTPLALEPSSTPGSKKSPP 2377
Query: 306 TQPPKKA-VEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPP------PAKKA 358
K+A K +P + + +S + P + + AT+ P PA +
Sbjct: 2378 EPVDKRAKAPKARPAPPQPSPAPPAFTSCPAPE--PFAELPAPATSLAPAPLITMPATRP 2435
Query: 359 AESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLT 418
+ +++ ++ P + A ++ + KS K A ++ G G
Sbjct: 2436 KPKKARAAEESGAKGPRRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEP 2495
Query: 419 RKADSSSSEEESSSSEEEKTKKMVATT-----------------KPKATAKAALSLPAKQ 461
+ S S ++ S E K AT PK+ KA +
Sbjct: 2496 KSLLSLGSYPPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAE 2555
Query: 462 APQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGG---------AAPSK---PASA 509
+ S SSS S SSSS + ++ + GG AA S+ PAS+
Sbjct: 2556 ESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASS 2615
Query: 510 KKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEE 569
+ SS+SSSS SS S + ++ +S+ ++ + ++ +S +E
Sbjct: 2616 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDE 2675
Query: 570 KK------KAAVVVSKSGSLKKRKQNEAAKEA--ETPQAKKIKLQTPNTFPK 613
+AA + S + +A K+A P A +TP P+
Sbjct: 2676 DSSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQ 2727
Score = 60.5 bits (145), Expect = 5e-09
Identities = 159/729 (21%), Positives = 268/729 (36%), Gaps = 150/729 (20%)
Query: 45 ANASSLLDI----YSFWLKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEV--- 97
A SSL D+ F ++ A+V + + + K +++ DSED EE
Sbjct: 1468 AMKSSLEDMDALELDFRMRLAEVQRQYKEKQRELVKLQRRR----DSEDRREEPHRSLAR 1523
Query: 98 QGPPAKKAAVPAKRVGLPP---GKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQA 154
+GP + A PP GK+ + + SS + DD E + KG + +
Sbjct: 1524 RGPGRPRKRTHAPSALSPPRKRGKSGHSSGKLSSKSLLTSDDYELGAGIRKRHKGSEEEH 1583
Query: 155 KA----AKAPPKKAKSSDSDSDS-------------SSEDEPPKNQKPKITPVTVKAQTK 197
A KA + + ++ S +S+ E ++ K +T + + K
Sbjct: 1584 DALIGMGKARGRNQTWDEHEASSDFISQLKIKKKKMASDQEQLASKLDKALSLTKQDKLK 1643
Query: 198 APPKPARAA------------------PKIANGKAASSSSSSSSSSSSDDSEEEKAAATP 239
+P K + +A + + A + S SS + + ++AA T
Sbjct: 1644 SPFKFSDSAGGKSKTSGGCGRYLTPYDSLLGKNRKALAKGLGLSLKSSREGKHKRAAKTR 1703
Query: 240 KKTVPKKQVVAKAPVKAATTP--TRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPS- 296
K V K A+ K+A +P + SS S ++ S+E+EE K GP SS PS
Sbjct: 1704 KMEVGFK---ARGQPKSAHSPFASEVSSYSYNTDSEEDEEFLKDEWPAQGPSSSKLTPSL 1760
Query: 297 -----APPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTK 351
A K + G + K+ + + ++ +S +K P ++ +A +
Sbjct: 1761 LCSMVAKNSKAAGGPKLTKRGLAAPRTLKPKPATS----------RKQPFCLLLREAEAR 1810
Query: 352 PPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVG 411
++SS +S D D S ++E + +S G
Sbjct: 1811 ----SSFSDSSEESFDQDESSEEEDEEEELEEEDEAS----------------------G 1844
Query: 412 GGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSS 471
GG +L R+ S EES + A+ P T +LS+ +A Q +R
Sbjct: 1845 GGYRLGARERALSPGLEESGLG---LLARFAASALPSPTVGPSLSVVQLEAKQKAR-KKE 1900
Query: 472 DSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSK------PASAKKGKAESSNSSSSDDS 525
+ S E E S+S VK + + AG P K P+ A SS D
Sbjct: 1901 ERQSLLGTEFEYTDSESEVKVRKRSPAGLLRPKKGLGEPGPSLAAPTPGARGPDPSSPDK 1960
Query: 526 SE------EEEEKLKGKGSPRPQA-PKANGTSALTAQNGK--------AAKNSEEEEEEK 570
++ + KL+G P +A P+A+ T + + AA +
Sbjct: 1961 AKLAVEKGRKARKLRGPKEPGFEAGPEASDDDLWTRRRSERIFLHDASAAAPAPVSTAPA 2020
Query: 571 KKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVRE 630
K + +K G L RK AK+ + P+ KK K K+ A P R
Sbjct: 2021 TKTSRC-AKGGPLSPRKDAGRAKDRKDPRKKK----------KGKEAGPGAGLPPPRAPA 2069
Query: 631 EEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGSISVQ 690
E + A + AKR +K K+ E K+ RG +GG++S
Sbjct: 2070 LPSEARAPHASSLTAAKR----------------SKAKAKGKEVKKENRG--KGGAVSKL 2111
Query: 691 VNSIKFDSE 699
+ S+ + +
Sbjct: 2112 MESMAAEED 2120
Score = 60.1 bits (144), Expect = 7e-09
Identities = 120/557 (21%), Positives = 198/557 (35%), Gaps = 75/557 (13%)
Query: 29 EVANKFAKATGATQQDANAS--SLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASSSD 86
++A+K KA T+QD S D K++ R L + K +K +
Sbjct: 1625 QLASKLDKALSLTKQDKLKSPFKFSDSAGGKSKTSGGCGRYLTPYDSLLGKNRKALAKGL 1684
Query: 87 --SEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQ 144
S SS E + + +K V K G P + ASE SS ++D +++E+ K
Sbjct: 1685 GLSLKSSREGKHKRAAKTRKMEVGFKARGQPKSAHSPFASEVSSYSYNTDSEEDEEFLKD 1744
Query: 145 PVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQK----PKITPVTVKAQTKAPP 200
P + SS + S KN K PK+T + A P
Sbjct: 1745 EW--------------PAQGPSSSKLTPSLLCSMVAKNSKAAGGPKLTKRGLAAPRTLKP 1790
Query: 201 KPARAAPK-----IANGKAASSSSSSSS-------SSSSDDSEEE--------------- 233
KPA + + + +A SS S SS SS +D EEE
Sbjct: 1791 KPATSRKQPFCLLLREAEARSSFSDSSEESFDQDESSEEEDEEEELEEEDEASGGGYRLG 1850
Query: 234 --KAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSS----EDSSSDEEEEQKKPMKNKPG 287
+ A +P ++A+ A +PT S S E ++E+++ +
Sbjct: 1851 ARERALSPGLEESGLGLLARFAASALPSPTVGPSLSVVQLEAKQKARKKEERQSLLGTEF 1910
Query: 288 PYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSK 347
Y+ + G PKK + + P ++ S +K K
Sbjct: 1911 EYTDSESEVKVRKRSPAGLLRPKKGLGEPGPSLAAPTPGARGPDPSSPDKAKLAVEKGRK 1970
Query: 348 ATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPK 407
A P + E+ ++SD D S+ S+ PA + +PA K + K
Sbjct: 1971 ARKLRGPKEPGFEAGPEASDDDLWT--RRRSERIFLHDASAAAPAPVSTAPATKTSRCAK 2028
Query: 408 QPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSR 467
GG L+ + D+ +++ +++K K+ A LP +AP
Sbjct: 2029 ----GGP--LSPRKDAGRAKDRKDPRKKKKGKE----------AGPGAGLPPPRAPALPS 2072
Query: 468 DSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSE 527
++ + SS + + K + K + G A SK + AE + D S
Sbjct: 2073 EARAPHASSLTAAKRSKAKAKGKEVKKENRGKGGAVSKLMESM--AAEEDFEPNQDSSFS 2130
Query: 528 EEEEKLKGKGSPRPQAP 544
E+E +G RP P
Sbjct: 2131 EDEHLPRGGAVERPLTP 2147
Score = 39.3 bits (90), Expect = 0.013
Identities = 87/426 (20%), Positives = 143/426 (33%), Gaps = 58/426 (13%)
Query: 244 PKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKS 303
P ++ P A P+ K S + S E K G + P A +
Sbjct: 2282 PDYKIQCAEPSPALLVPSAKRRSRKTSKDTGE--------GKDGGTAGSEEPGAKA--RG 2331
Query: 304 LGTQPPKKAVEKQQPVESSEDSSDE--------SDSSSEEEKKPPTKAVVSKATTKPPPA 355
G +P KA + + +DE SS+ KK P + V +A K P A
Sbjct: 2332 RGRKPSAKAKGDRAATLEEGNPTDEVPSTPLALEPSSTPGSKKSPPEPVDKRA--KAPKA 2389
Query: 356 KKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAP--KQPVGGG 413
+ A S P+ PA T+ + +P +PA A AP P
Sbjct: 2390 RPAPPQPS-------------PAPPAFTSCPAP-EPFAELPAPATSLAPAPLITMPATRP 2435
Query: 414 QKLLTRKADSSSSEEESSSSEEEKTKKMV---ATTKPKAT-AKAALSLPAK------QAP 463
+ R A+ S ++ EE + + T PK+ AK AL L Q P
Sbjct: 2436 KPKKARAAEESGAKGPRRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEP 2495
Query: 464 QGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGA---------APSKPASAKKG-- 512
+ S ++ S E + K+ Q+ G +P K + + G
Sbjct: 2496 KSLLSLGSYPPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAE 2555
Query: 513 KAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSAL-TAQNGKAAKNSEEEEEEKK 571
++ESS+SSSS SS G + + NG T +A +S
Sbjct: 2556 ESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASS 2615
Query: 572 KAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREE 631
++ S S S + ++ + + + + ++ +SS +E
Sbjct: 2616 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDE 2675
Query: 632 EIEVDS 637
+ S
Sbjct: 2676 DSSCSS 2681
Score = 33.5 bits (75), Expect = 0.69
Identities = 34/145 (23%), Positives = 58/145 (40%), Gaps = 9/145 (6%)
Query: 28 SEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASSSDS 87
S A+ + ++ ++ +++SS S S+ ++ + + +SSS S
Sbjct: 2607 SRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2666
Query: 88 EDSSEEEEEVQGPPAKKAAVPAKRVG-----LPPGKAAAKASESSSSEESSDDDDEEDQK 142
SS +E + A PA G P KA +A ++ S S Q
Sbjct: 2667 SSSSSTTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQP 2726
Query: 143 KQPVQKGVKP-QAKA---AKAPPKK 163
+ P + +P Q KA AK+ PKK
Sbjct: 2727 QAPPPQPTQPLQPKAQAGAKSRPKK 2751
Score = 31.2 bits (69), Expect = 3.4
Identities = 22/97 (22%), Positives = 43/97 (44%), Gaps = 2/97 (2%)
Query: 257 ATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQ 316
A +P +S ++ + QK +KP Y+ PS+ P + PP + ++
Sbjct: 989 AVSPPPSPRASPVAALKAKVIQKLEDVSKPPAYAYPATPSSHPTSPPPASPPPTPGITRK 1048
Query: 317 QPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPP 353
+ E+ E+ ++ D E+E P +A+ S + P
Sbjct: 1049 E--EAPENVVEKKDLELEKEAPSPFQALFSDIPPRYP 1083
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.293 0.112 0.286
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,759,144
Number of Sequences: 37866
Number of extensions: 1754614
Number of successful extensions: 51652
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1028
Number of HSP's successfully gapped in prelim test: 2622
Number of HSP's that attempted gapping in prelim test: 13628
Number of HSP's gapped (non-prelim): 18606
length of query: 699
length of database: 18,247,518
effective HSP length: 109
effective length of query: 590
effective length of database: 14,120,124
effective search space: 8330873160
effective search space used: 8330873160
T: 11
A: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 44 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.