Search of human proteins with 148529011

Search of human proteins with 148529011

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148529011 coronin, actin binding protein, 2B [Homo sapiens]
         (480 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148529011 coronin, actin binding protein, 2B [Homo sapiens]        986   0.0  
gi|209529711 coronin, actin binding protein, 2A [Homo sapiens]        670   0.0  
gi|16554585 coronin, actin binding protein, 2A [Homo sapiens]         670   0.0  
gi|7656991 coronin, actin binding protein, 1C isoform 1 [Homo sa...   417   e-117
gi|109627650 coronin 6 [Homo sapiens]                                 410   e-114
gi|5902134 coronin, actin binding protein, 1A [Homo sapiens]          408   e-114
gi|65787364 coronin, actin binding protein, 1B [Homo sapiens]         405   e-113
gi|14149734 coronin, actin binding protein, 1B [Homo sapiens]         405   e-113
gi|168229161 coronin 7 [Homo sapiens]                                 209   3e-54
gi|16554629 WD repeat domain 5 [Homo sapiens]                          80   5e-15
gi|16554627 WD repeat domain 5 [Homo sapiens]                          80   5e-15
gi|23199987 WD repeat domain 5B [Homo sapiens]                         74   2e-13
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    70   3e-12
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]             67   3e-11
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa...    67   5e-11
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa...    67   5e-11
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi...    67   5e-11
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          66   8e-11
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          66   8e-11
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]          66   8e-11
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]            66   8e-11
gi|19913367 transducin beta-like 1Y [Homo sapiens]                     65   1e-10
gi|19913365 transducin beta-like 1Y [Homo sapiens]                     65   1e-10
gi|15150805 transducin beta-like 1Y [Homo sapiens]                     65   1e-10
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ...    65   1e-10
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ...    65   1e-10
gi|32189425 WD repeat domain 69 [Homo sapiens]                         63   5e-10
gi|7706657 cell division cycle 40 homolog [Homo sapiens]               62   9e-10
gi|4757988 WD repeat domain 39 [Homo sapiens]                          61   2e-09
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...    60   3e-09

>gi|148529011 coronin, actin binding protein, 2B [Homo sapiens]
          Length = 480

 Score =  986 bits (2549), Expect = 0.0
 Identities = 480/480 (100%), Positives = 480/480 (100%)

Query: 1   MTVTKMSWRPQYRSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESA 60
           MTVTKMSWRPQYRSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESA
Sbjct: 1   MTVTKMSWRPQYRSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESA 60

Query: 61  GGGSFLVIPLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEG 120
           GGGSFLVIPLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEG
Sbjct: 61  GGGSFLVIPLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEG 120

Query: 121 GLKRNMTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHT 180
           GLKRNMTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHT
Sbjct: 121 GLKRNMTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHT 180

Query: 181 DVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTT 240
           DVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTT
Sbjct: 181 DVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTT 240

Query: 241 GVSRWNTRQIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEI 300
           GVSRWNTRQIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEI
Sbjct: 241 GVSRWNTRQIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEI 300

Query: 301 STEKPYLSYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRR 360
           STEKPYLSYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRR
Sbjct: 301 STEKPYLSYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRR 360

Query: 361 SDSYQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLKEGYKKSSKMVFKAPIKEKKSVV 420
           SDSYQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLKEGYKKSSKMVFKAPIKEKKSVV
Sbjct: 361 SDSYQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLKEGYKKSSKMVFKAPIKEKKSVV 420

Query: 421 VNGIDLLENVPPRTENELLRMFFRQQDEIRRLKEELAQKDIRIRQLQLELKNLRNSPKNC 480
           VNGIDLLENVPPRTENELLRMFFRQQDEIRRLKEELAQKDIRIRQLQLELKNLRNSPKNC
Sbjct: 421 VNGIDLLENVPPRTENELLRMFFRQQDEIRRLKEELAQKDIRIRQLQLELKNLRNSPKNC 480


>gi|209529711 coronin, actin binding protein, 2A [Homo sapiens]
          Length = 525

 Score =  670 bits (1729), Expect = 0.0
 Identities = 319/519 (61%), Positives = 403/519 (77%), Gaps = 50/519 (9%)

Query: 6   MSWRPQYRSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESAGGGSF 65
           MSW PQYRSSKFR+V+GK A++E+C+D +PIT++VHDNHFCAVN  F+A+VTE AGGG+F
Sbjct: 1   MSWHPQYRSSKFRHVFGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAF 60

Query: 66  LVIPLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRN 125
           LVIPL QTG+++P+YPKVCGH+GNVLD+KWNPF D  IASCSED +++IW IP+  L RN
Sbjct: 61  LVIPLHQTGKLDPHYPKVCGHRGNVLDVKWNPFDDFEIASCSEDATIKIWSIPKQLLTRN 120

Query: 126 MTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGE-----PVKMIDCHT 180
           +T    EL GH+RRVGLVEWHPT  NILFSAGYDYKV+IWNLD  E     P+  I CH 
Sbjct: 121 LTAYRKELVGHARRVGLVEWHPTAANILFSAGYDYKVMIWNLDTKESVITSPMSTISCHQ 180

Query: 181 DVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTT 240
           DVIL MSFNT+GSLL TTCKD+K+RVI+PR+G VLQEA+ K HR ++V+FLGN+K+L++T
Sbjct: 181 DVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEASYKGHRASKVLFLGNLKKLMST 240

Query: 241 GVSRWNTRQIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEI 300
           G SRWN RQ+ALWDQ++LS+PL+EE++DG SG+LFPFYDADT MLY+ GKGDGNIRYYE+
Sbjct: 241 GTSRWNNRQVALWDQDNLSVPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEV 300

Query: 301 STEKPYLSYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRR 360
           S +KP+LSYL E+RS  PQKG+GVMPK GLDVS+CE+FRFYKL+T K LIEPISMIVPRR
Sbjct: 301 SADKPHLSYLTEYRSYNPQKGIGVMPKRGLDVSSCEIFRFYKLITTKSLIEPISMIVPRR 360

Query: 361 SDSYQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLK---------------------- 398
           S+SYQEDIYP T G +P+LT  EWL G+NRDP+L+SL+                      
Sbjct: 361 SESYQEDIYPPTAGAQPSLTAQEWLSGMNRDPILVSLRPGSELLRPHPLPAERPIFNSMA 420

Query: 399 ----------------EGYKKSSKMVFKAP-------IKEKKSVVVNGIDLLENVPPRTE 435
                           +G++ SS +  K P       ++EKK+ + NG D+ E  PP+TE
Sbjct: 421 PASPRLLNQTEKLAAEDGWRSSSLLEEKMPRWAAEHRLEEKKTWLTNGFDVFECPPPKTE 480

Query: 436 NELLRMFFRQQDEIRRLKEELAQKDIRIRQLQLELKNLR 474
           NELL+MF+RQQ+EIRRL+E L Q++++ +QL+LE+KNLR
Sbjct: 481 NELLQMFYRQQEEIRRLRELLTQREVQAKQLELEIKNLR 519


>gi|16554585 coronin, actin binding protein, 2A [Homo sapiens]
          Length = 525

 Score =  670 bits (1729), Expect = 0.0
 Identities = 319/519 (61%), Positives = 403/519 (77%), Gaps = 50/519 (9%)

Query: 6   MSWRPQYRSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESAGGGSF 65
           MSW PQYRSSKFR+V+GK A++E+C+D +PIT++VHDNHFCAVN  F+A+VTE AGGG+F
Sbjct: 1   MSWHPQYRSSKFRHVFGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAF 60

Query: 66  LVIPLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRN 125
           LVIPL QTG+++P+YPKVCGH+GNVLD+KWNPF D  IASCSED +++IW IP+  L RN
Sbjct: 61  LVIPLHQTGKLDPHYPKVCGHRGNVLDVKWNPFDDFEIASCSEDATIKIWSIPKQLLTRN 120

Query: 126 MTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGE-----PVKMIDCHT 180
           +T    EL GH+RRVGLVEWHPT  NILFSAGYDYKV+IWNLD  E     P+  I CH 
Sbjct: 121 LTAYRKELVGHARRVGLVEWHPTAANILFSAGYDYKVMIWNLDTKESVITSPMSTISCHQ 180

Query: 181 DVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTT 240
           DVIL MSFNT+GSLL TTCKD+K+RVI+PR+G VLQEA+ K HR ++V+FLGN+K+L++T
Sbjct: 181 DVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEASYKGHRASKVLFLGNLKKLMST 240

Query: 241 GVSRWNTRQIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEI 300
           G SRWN RQ+ALWDQ++LS+PL+EE++DG SG+LFPFYDADT MLY+ GKGDGNIRYYE+
Sbjct: 241 GTSRWNNRQVALWDQDNLSVPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEV 300

Query: 301 STEKPYLSYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRR 360
           S +KP+LSYL E+RS  PQKG+GVMPK GLDVS+CE+FRFYKL+T K LIEPISMIVPRR
Sbjct: 301 SADKPHLSYLTEYRSYNPQKGIGVMPKRGLDVSSCEIFRFYKLITTKSLIEPISMIVPRR 360

Query: 361 SDSYQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLK---------------------- 398
           S+SYQEDIYP T G +P+LT  EWL G+NRDP+L+SL+                      
Sbjct: 361 SESYQEDIYPPTAGAQPSLTAQEWLSGMNRDPILVSLRPGSELLRPHPLPAERPIFNSMA 420

Query: 399 ----------------EGYKKSSKMVFKAP-------IKEKKSVVVNGIDLLENVPPRTE 435
                           +G++ SS +  K P       ++EKK+ + NG D+ E  PP+TE
Sbjct: 421 PASPRLLNQTEKLAAEDGWRSSSLLEEKMPRWAAEHRLEEKKTWLTNGFDVFECPPPKTE 480

Query: 436 NELLRMFFRQQDEIRRLKEELAQKDIRIRQLQLELKNLR 474
           NELL+MF+RQQ+EIRRL+E L Q++++ +QL+LE+KNLR
Sbjct: 481 NELLQMFYRQQEEIRRLRELLTQREVQAKQLELEIKNLR 519


>gi|7656991 coronin, actin binding protein, 1C isoform 1 [Homo
           sapiens]
          Length = 474

 Score =  417 bits (1073), Expect = e-117
 Identities = 215/472 (45%), Positives = 307/472 (65%), Gaps = 16/472 (3%)

Query: 13  RSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESAGGGSFLVIPLEQ 72
           R SKFR+V+G+    + C+D I +++   D+ FCAVN RF+AI+ E++GGG+FLV+PL +
Sbjct: 6   RQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHK 65

Query: 73  TGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLE 132
           TGRI+ +YP VCGH G VLDI W P  D +IAS SED +V +W+IPE GL  ++TE ++ 
Sbjct: 66  TGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVI 125

Query: 133 LHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEP-VKMIDCHTDVILCMSFNTD 191
           L GHS+RVG+V WHPT  N+L SAG D  ++IWN+  GE  + + D H+D+I  +S+N +
Sbjct: 126 LEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWNRN 185

Query: 192 GSLLTTTCKDKKLRVIEPRSGRVLQEANCKNH---RVNRVVFLGNMKRLLTTGVSRWNTR 248
           GSL+ T  KDKK+RVI+PR   ++ E   K H   R  R +FL +   + TTG SR + R
Sbjct: 186 GSLICTASKDKKVRVIDPRKQEIVAEKE-KAHEGARPMRAIFLAD-GNVFTTGFSRMSER 243

Query: 249 QIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTEKPYLS 308
           Q+ALW+ +++  P+   E+D  +G+L PFYD DT ++YL GKGD +IRY+EI+ E PY+ 
Sbjct: 244 QLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVH 303

Query: 309 YLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRRSDSYQEDI 368
           YL  F S  PQ+G+G MPK GLDV+ CE+ RF+KL   K   EPI M VPR+SD +Q+D+
Sbjct: 304 YLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERK--CEPIIMTVPRKSDLFQDDL 361

Query: 369 YPMTPGTEPALTPDEWLGGINRDPVLMSLKEGY---KKSSKMVFKAPIKEKKSVVVNGID 425
           YP T G E AL  +EW  G N DP+L+SLK GY   K     V K  I + K       D
Sbjct: 362 YPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKCD 421

Query: 426 LLENVPPRTENELLRMFFRQQD----EIRRLKEELAQKDIRIRQLQLELKNL 473
           L+ ++P +T +        + D    EI+ +K+ +  +D RI +L+ ++  +
Sbjct: 422 LI-SIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKLEQQMAKI 472


>gi|109627650 coronin 6 [Homo sapiens]
          Length = 472

 Score =  410 bits (1054), Expect = e-114
 Identities = 211/468 (45%), Positives = 298/468 (63%), Gaps = 17/468 (3%)

Query: 13  RSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESAGGGSFLVIPLEQ 72
           R SKFR+V+G+ A  +  ++ I ++K   D+ FCAVN +FLAI+ E+ GGG+F+V+PL +
Sbjct: 7   RQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAK 66

Query: 73  TGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLE 132
           TGR++ NYP V GH   VLDI W P  DN+IAS S+DT++ +W+IP+    RN+TE ++ 
Sbjct: 67  TGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIIT 126

Query: 133 LHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEP-VKMIDCHTDVILCMSFNTD 191
           L GHS+RVG++ WHPT  N+L SAG D  ++IWN+  GE  + + D H DVI  + +N++
Sbjct: 127 LEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLDDMHPDVIHSVCWNSN 186

Query: 192 GSLLTTTCKDKKLRVIEPRSGRVLQE--ANCKNHRVNRVVFLGNMKRLLTTGVSRWNTRQ 249
           GSLL TTCKDK LR+I+PR G+V+ E  A  +  R  R VF      + TTG +R + R+
Sbjct: 187 GSLLATTCKDKTLRIIDPRKGQVVAERFAAHEGMRPMRAVFT-RQGHIFTTGFTRMSQRE 245

Query: 250 IALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTEKPYLSY 309
           + LWD  +   P+  +E+D  +G+L PFYD D+ ++YL GKGD +IRY+EI+ E P++ Y
Sbjct: 246 LGLWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHY 305

Query: 310 LMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRRSDSYQEDIY 369
           L  F S  PQ+G+G MPK GLDVS CE+ RFYKL   K   EPI M VPR+SD +Q+D+Y
Sbjct: 306 LNTFSSKEPQRGMGFMPKRGLDVSKCEIARFYKLHERK--CEPIIMTVPRKSDLFQDDLY 363

Query: 370 PMTPGTEPALTPDEWLGGINRDPVLMSLKEGYKKSSKMVFKAPIKEKKSVVV--NGIDLL 427
           P TPG EPAL  DEWL G + +PVL+SL++GY          P K ++  V   N +D+ 
Sbjct: 364 PDTPGPEPALEADEWLSGQDAEPVLISLRDGY---------VPPKHRELRVTKRNILDVR 414

Query: 428 ENVPPRTENELLRMFFRQQDEIRRLKEELAQKDIRIRQLQLELKNLRN 475
               PR           QQ  +  L EE+     R++  +  +  L N
Sbjct: 415 PPSGPRRSQSASDAPLSQQHTLETLLEEIKALRERVQAQEQRITALEN 462


>gi|5902134 coronin, actin binding protein, 1A [Homo sapiens]
          Length = 461

 Score =  408 bits (1049), Expect = e-114
 Identities = 207/473 (43%), Positives = 304/473 (64%), Gaps = 23/473 (4%)

Query: 9   RPQYRSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESAGGGSFLVI 68
           R   RSSKFR+V+G+ A  + C++ + +++   D+ FCAVN +F+A++ E++GGG+FLV+
Sbjct: 3   RQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFLVL 62

Query: 69  PLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTE 128
           PL +TGR++ N P VCGH   VLDI W P  DN+IAS SED +V +WEIP+GGL   + E
Sbjct: 63  PLGKTGRVDKNAPTVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLMLPLRE 122

Query: 129 ALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMI--DCHTDVILCM 186
            ++ L GH++RVG+V WH T  N+L SAG D  +++W++  G  +  +  + H D I  +
Sbjct: 123 PVVTLEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLGPEVHPDTIYSV 182

Query: 187 SFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNH--RVNRVVFLGNMKRLLTTGVSR 244
            ++ DG L+ T+C+DK++R+IEPR G V+ E +  +   R  R VF+   K +LTTG SR
Sbjct: 183 DWSRDGGLICTSCRDKRVRIIEPRKGTVVAEKDRPHEGTRPVRAVFVSEGK-ILTTGFSR 241

Query: 245 WNTRQIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTEK 304
            + RQ+ALWD + L  PL  +E+D  SG+L PF+D DT+++YL GKGD +IRY+EI++E 
Sbjct: 242 MSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEA 301

Query: 305 PYLSYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRRSDSY 364
           P+L YL  F S   Q+G+G MPK GL+V+ CE+ RFYKL   +   EPI+M VPR+SD +
Sbjct: 302 PFLHYLSMFSSKESQRGMGYMPKRGLEVNKCEIARFYKLHERR--CEPIAMTVPRKSDLF 359

Query: 365 QEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLKEGYKKSSKMVFKAPIKEKKSVVVNGI 424
           QED+YP T G +PALT +EWLGG +  P+L+SLK+GY          P K ++  V  G+
Sbjct: 360 QEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGY---------VPPKSRELRVNRGL 410

Query: 425 DL-LENVPPRTENELLRMFFRQQDEIRRLKEELAQKDIRIRQLQLELKNLRNS 476
           D       P              D + RL+EE+ +    +++LQ  L  L  +
Sbjct: 411 DTGRRRAAPEASGT------PSSDAVSRLEEEMRKLQATVQELQKRLDRLEET 457


>gi|65787364 coronin, actin binding protein, 1B [Homo sapiens]
          Length = 489

 Score =  405 bits (1042), Expect = e-113
 Identities = 200/409 (48%), Positives = 278/409 (67%), Gaps = 8/409 (1%)

Query: 6   MSWRPQYRSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESAGGGSF 65
           MS+R   R SKFR+V+G+    + C++ I +++   D+ FCAVN +FLA++ E++GGG+F
Sbjct: 1   MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAF 60

Query: 66  LVIPLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRN 125
           LV+PL +TGRI+  YP VCGH G VLDI W P  D +IAS SED +V +W+IPE GL   
Sbjct: 61  LVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSP 120

Query: 126 MTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMID-CHTDVIL 184
           +TE ++ L GH++RVG++ WHPT  N+L SAG D  VLIWN+   E +  +D  H D+I 
Sbjct: 121 LTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIY 180

Query: 185 CMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNH---RVNRVVFLGNMKRLLTTG 241
            +S+N +GSL  + CKDK +R+I+PR G ++ E   K H   R  R +FL + K + TTG
Sbjct: 181 NVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAERE-KAHEGARPMRAIFLADGK-VFTTG 238

Query: 242 VSRWNTRQIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEIS 301
            SR + RQ+ALWD E+L  P+  +E+D  +G L PFYD DT ++Y+ GKGD +IRY+EI+
Sbjct: 239 FSRMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEIT 298

Query: 302 TEKPYLSYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRRS 361
            E PY+ +L  F S  PQ+G+G MPK GL+VS CE+ RFYKL   K   EPI M VPR+S
Sbjct: 299 EEPPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERK--CEPIVMTVPRKS 356

Query: 362 DSYQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLKEGYKKSSKMVFK 410
           D +Q+D+YP T G E AL  +EW+ G + DP+L+SL+E Y  S +   K
Sbjct: 357 DLFQDDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLK 405


>gi|14149734 coronin, actin binding protein, 1B [Homo sapiens]
          Length = 489

 Score =  405 bits (1042), Expect = e-113
 Identities = 200/409 (48%), Positives = 278/409 (67%), Gaps = 8/409 (1%)

Query: 6   MSWRPQYRSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESAGGGSF 65
           MS+R   R SKFR+V+G+    + C++ I +++   D+ FCAVN +FLA++ E++GGG+F
Sbjct: 1   MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAF 60

Query: 66  LVIPLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRN 125
           LV+PL +TGRI+  YP VCGH G VLDI W P  D +IAS SED +V +W+IPE GL   
Sbjct: 61  LVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSP 120

Query: 126 MTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMID-CHTDVIL 184
           +TE ++ L GH++RVG++ WHPT  N+L SAG D  VLIWN+   E +  +D  H D+I 
Sbjct: 121 LTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIY 180

Query: 185 CMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNH---RVNRVVFLGNMKRLLTTG 241
            +S+N +GSL  + CKDK +R+I+PR G ++ E   K H   R  R +FL + K + TTG
Sbjct: 181 NVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAERE-KAHEGARPMRAIFLADGK-VFTTG 238

Query: 242 VSRWNTRQIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEIS 301
            SR + RQ+ALWD E+L  P+  +E+D  +G L PFYD DT ++Y+ GKGD +IRY+EI+
Sbjct: 239 FSRMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEIT 298

Query: 302 TEKPYLSYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRRS 361
            E PY+ +L  F S  PQ+G+G MPK GL+VS CE+ RFYKL   K   EPI M VPR+S
Sbjct: 299 EEPPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERK--CEPIVMTVPRKS 356

Query: 362 DSYQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLKEGYKKSSKMVFK 410
           D +Q+D+YP T G E AL  +EW+ G + DP+L+SL+E Y  S +   K
Sbjct: 357 DLFQDDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLK 405


>gi|168229161 coronin 7 [Homo sapiens]
          Length = 925

 Score =  209 bits (533), Expect = 3e-54
 Identities = 133/393 (33%), Positives = 203/393 (51%), Gaps = 12/393 (3%)

Query: 14  SSKFRNVYGKVANREHCFD---GIPITKNVHDNHFCAVNTRFLAIVTESAGGGSFLVIPL 70
           SSKFR+  G V +R+       G+ +T     + FCA   R    +  S  GG   V+ L
Sbjct: 470 SSKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLSS--GGQVAVLEL 527

Query: 71  EQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEAL 130
            + GR+         +   V D+ W+PF  + +A   ED  +R+W +P  GL+  +T   
Sbjct: 528 RKPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPE 587

Query: 131 LELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNT 190
             L GH+ ++  + +HP   N+L S+ YD  V IW+L  G     +  H D I  ++++ 
Sbjct: 588 TVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSP 647

Query: 191 DGSLLTTTCKDKKLRVIEPRSG-RVLQEA-NCKNHRVNRVVFLGNMKRLLTTGVSRWNTR 248
           DG  L T CKD ++RV  PRSG   LQE    K  R  R+V++ + + LL +G    + R
Sbjct: 648 DGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSER 707

Query: 249 QIALWDQEDLS-MPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTEKPYL 307
           Q+ L++ E L+  PL    +D     L P YD DT ++ L GKGD  +  YE+  E P+ 
Sbjct: 708 QLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFF 767

Query: 308 SYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPR-RSDSYQE 366
                F SP P KGL ++PK   DV   E+ R  +L   +  +EP++  +PR R + +Q+
Sbjct: 768 LECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRL--RQSSLEPVAFRLPRVRKEFFQD 825

Query: 367 DIYPMTPGT-EPALTPDEWLGGINRDPVLMSLK 398
           D++P T    EP L+ + WL G N  P L+SL+
Sbjct: 826 DVFPDTAVIWEPVLSAEAWLQGANGQPWLLSLQ 858



 Score =  177 bits (449), Expect = 2e-44
 Identities = 117/394 (29%), Positives = 198/394 (50%), Gaps = 18/394 (4%)

Query: 11  QYRSSKFRNVYGKVANREHCFDGI-----PITKNVHDNHFCAVNTRFLAIVTESAGGGSF 65
           ++R SKFR+   +   RE     I     P  +N H    C++      I   S   G  
Sbjct: 3   RFRVSKFRHTEARPPRRESWISDIRAGTAPSCRN-HIKSSCSL------IAFNSDRPGVL 55

Query: 66  LVIPLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRN 125
            ++PL+  G  +     +  H   V D+ ++PF D ++A+ S D +V++W +P  G    
Sbjct: 56  GIVPLQGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALP 115

Query: 126 MTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILC 185
               ++ L      V ++++HPT++ IL SA     V +W+    +P+  +  H D++  
Sbjct: 116 SAPGVV-LGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQPLTELAAHGDLVQS 173

Query: 186 MSFNTDGSLLTTTCKDKKLRVIEPRSG-RVLQEANC-KNHRVNRVVFLGNMKRLLTTGVS 243
             ++ DG+L+ T CKDK+LR+ +PR+  R  Q     +N R +R+ ++G  + L++TG +
Sbjct: 174 AVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFN 233

Query: 244 RWNTRQIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTE 303
           +   R++ LWD    S  L    +D   G L P  D D+ +L LAGKG+  +  YE+  +
Sbjct: 234 QMREREVKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQ 293

Query: 304 KPYLSYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRRSDS 363
           +P LS + +    +  +G  ++P+  L V +CEV R  +L      I PI   VPR++  
Sbjct: 294 QPALSPVTQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDT--AIVPIGYHVPRKAVE 351

Query: 364 YQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSL 397
           + ED++P T G  PA  P  W  G N+    +SL
Sbjct: 352 FHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSL 385


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 51/173 (29%), Positives = 91/173 (52%), Gaps = 14/173 (8%)

Query: 83  VCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGL 142
           + GH+  + D+ W+    N++ S S+D +++IW++  G       + L  L GHS  V  
Sbjct: 83  ISGHKLGISDVAWSSD-SNLLVSASDDKTLKIWDVSSG-------KCLKTLKGHSNYVFC 134

Query: 143 VEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDK 202
             ++P +N ++ S  +D  V IW++  G+ +K +  H+D +  + FN DGSL+ ++  D 
Sbjct: 135 CNFNPQSN-LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDG 193

Query: 203 KLRVIEPRSGRVLQE-ANCKNHRVNRVVFLGNMKRLLTTGVSRWNTRQIALWD 254
             R+ +  SG+ L+   +  N  V+ V F  N K +L   +   NT  + LWD
Sbjct: 194 LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLD--NT--LKLWD 242



 Score = 36.6 bits (83), Expect = 0.052
 Identities = 25/116 (21%), Positives = 55/116 (47%), Gaps = 8/116 (6%)

Query: 93  IKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEWHPTTNNI 152
           +K++P    I+A+  ++T +++W+  +G   +  T      H + +      +  T    
Sbjct: 220 VKFSPNGKYILAATLDNT-LKLWDYSKGKCLKTYTG-----HKNEKYCIFANFSVTGGKW 273

Query: 153 LFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTC--KDKKLRV 206
           + S   D  V IWNL   E V+ +  HTDV++  + +   +++ +     DK +++
Sbjct: 274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 51/173 (29%), Positives = 91/173 (52%), Gaps = 14/173 (8%)

Query: 83  VCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGL 142
           + GH+  + D+ W+    N++ S S+D +++IW++  G       + L  L GHS  V  
Sbjct: 83  ISGHKLGISDVAWSSD-SNLLVSASDDKTLKIWDVSSG-------KCLKTLKGHSNYVFC 134

Query: 143 VEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDK 202
             ++P +N ++ S  +D  V IW++  G+ +K +  H+D +  + FN DGSL+ ++  D 
Sbjct: 135 CNFNPQSN-LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDG 193

Query: 203 KLRVIEPRSGRVLQE-ANCKNHRVNRVVFLGNMKRLLTTGVSRWNTRQIALWD 254
             R+ +  SG+ L+   +  N  V+ V F  N K +L   +   NT  + LWD
Sbjct: 194 LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLD--NT--LKLWD 242



 Score = 36.6 bits (83), Expect = 0.052
 Identities = 25/116 (21%), Positives = 55/116 (47%), Gaps = 8/116 (6%)

Query: 93  IKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEWHPTTNNI 152
           +K++P    I+A+  ++T +++W+  +G   +  T      H + +      +  T    
Sbjct: 220 VKFSPNGKYILAATLDNT-LKLWDYSKGKCLKTYTG-----HKNEKYCIFANFSVTGGKW 273

Query: 153 LFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTC--KDKKLRV 206
           + S   D  V IWNL   E V+ +  HTDV++  + +   +++ +     DK +++
Sbjct: 274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 52/183 (28%), Positives = 90/183 (49%), Gaps = 15/183 (8%)

Query: 74  GRIEPNYPKVC-GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLE 132
           G  +  Y K   GH   + D+ W+     ++ S S+D ++++W++  G       + L  
Sbjct: 69  GAYDGKYEKTLYGHNLEISDVAWSSDSSRLV-SASDDKTLKLWDVRSG-------KCLKT 120

Query: 133 LHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDG 192
           L GHS  V    ++P +N ++ S  +D  V IW +  G+ +K +  H+D +  + FN  G
Sbjct: 121 LKGHSNYVFCCNFNPPSN-LIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSG 179

Query: 193 SLLTTTCKDKKLRVIEPRSGRVLQE-ANCKNHRVNRVVFLGNMKRLLTTGVSRWNTRQIA 251
           SL+ +   D   R+ +  SG+ L+   +  N  V+ V F  N K +LT  +   NT  + 
Sbjct: 180 SLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLD--NT--LK 235

Query: 252 LWD 254
           LWD
Sbjct: 236 LWD 238



 Score = 36.2 bits (82), Expect = 0.068
 Identities = 23/106 (21%), Positives = 47/106 (44%), Gaps = 7/106 (6%)

Query: 103 IASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKV 162
           I + + D ++++W+   G   +  T      H + +      +  T    + S   D  V
Sbjct: 225 ILTATLDNTLKLWDYSRGRCLKTYTG-----HKNEKYCIFANFSVTGGKWIVSGSEDNLV 279

Query: 163 LIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTC--KDKKLRV 206
            IWNL   E V+ +  HTDV++  + +   +L+ +     DK +++
Sbjct: 280 YIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKL 325


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 39/139 (28%), Positives = 74/139 (53%), Gaps = 16/139 (11%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVE 144
           GH   V  IKW+P   N++ASCS+D +++IW + +          + +L  H++ +  ++
Sbjct: 347 GHTNEVNAIKWDP-TGNLLASCSDDMTLKIWSMKQDN-------CVHDLQAHNKEIYTIK 398

Query: 145 WHPT---TNN-----ILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLT 196
           W PT   TNN     +L SA +D  V +W++D G  +  +  H + +  ++F+ DG  L 
Sbjct: 399 WSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLA 458

Query: 197 TTCKDKKLRVIEPRSGRVL 215
           +   DK + +   ++G ++
Sbjct: 459 SGSFDKCVHIWNTQTGALV 477



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 33/140 (23%), Positives = 57/140 (40%), Gaps = 10/140 (7%)

Query: 86  HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEW 145
           H+G +  +KWN    N I S   D +  IW+   G       EA  +   HS     V+W
Sbjct: 265 HKGPIFALKWNKK-GNFILSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 316

Query: 146 HPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLR 205
              +NN   S   D  + +  L    P+K    HT+ +  + ++  G+LL +   D  L+
Sbjct: 317 Q--SNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLK 374

Query: 206 VIEPRSGRVLQEANCKNHRV 225
           +   +    + +    N  +
Sbjct: 375 IWSMKQDNCVHDLQAHNKEI 394



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 37/151 (24%), Positives = 67/151 (44%), Gaps = 13/151 (8%)

Query: 76  IEPNYPKVC-GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGG--------LKRNM 126
           I PN   V  GH+  V    WNP + +++AS S D++ RIW + E          L+  +
Sbjct: 157 IPPNKAVVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCI 215

Query: 127 TEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCM 186
            E   ++   ++ V  ++W+ +   +L +  YD    IW  D G     +  H   I  +
Sbjct: 216 REGGQDVPS-NKDVTSLDWN-SEGTLLATGSYDGFARIWTKD-GNLASTLGQHKGPIFAL 272

Query: 187 SFNTDGSLLTTTCKDKKLRVIEPRSGRVLQE 217
            +N  G+ + +   DK   + +  +G   Q+
Sbjct: 273 KWNKKGNFILSAGVDKTTIIWDAHTGEAKQQ 303


>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
          Length = 425

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 53/211 (25%), Positives = 96/211 (45%), Gaps = 10/211 (4%)

Query: 71  EQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEAL 130
           + +G   P+  ++ GHQ     + WN  +   + S S+D +V +W+I  G  +  + +A 
Sbjct: 161 DPSGECNPDL-RLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAK 219

Query: 131 LELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNL---DVGEPVKMIDCHTDVILCMS 187
               GHS  V  V WH    ++  S   D K++IW+       +P  ++D HT  + C+S
Sbjct: 220 AIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLS 279

Query: 188 FNTDGS-LLTTTCKDKKLRVIEPRSGRV-LQEANCKNHRVNRVVFLGNMKRLLTTGVSRW 245
           FN     +L T   DK + + + R+ ++ L         + +V +  + + +L    S  
Sbjct: 280 FNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETIL---ASSG 336

Query: 246 NTRQIALWDQEDLSMPLIEEEI-DGLSGLLF 275
             R++ +WD   +      E+  DG   LLF
Sbjct: 337 TDRRLNVWDLSKIGEEQSAEDAEDGPPELLF 367



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 21/89 (23%), Positives = 45/89 (50%), Gaps = 7/89 (7%)

Query: 86  HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEA------LLELHG-HSR 138
           H+  +  + W+P  + I+AS   D  + +W++ + G +++  +A      LL +HG H+ 
Sbjct: 315 HKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTA 374

Query: 139 RVGLVEWHPTTNNILFSAGYDYKVLIWNL 167
           ++    W+P    ++ S   D  + IW +
Sbjct: 375 KISDFSWNPNEPWVICSVSEDNIMQIWQM 403



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 14/35 (40%), Positives = 20/35 (57%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPE 119
           GH   + D  WNP    +I S SED  ++IW++ E
Sbjct: 371 GHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAE 405


>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
           sapiens]
          Length = 390

 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 51/211 (24%), Positives = 96/211 (45%), Gaps = 10/211 (4%)

Query: 71  EQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEAL 130
           + +G   P+  ++ GHQ     + WNP +   + S S+D ++ +W+I     +  + +A 
Sbjct: 127 DPSGECNPDL-RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAK 185

Query: 131 LELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNL---DVGEPVKMIDCHTDVILCMS 187
               GH+  V  V WH    ++  S   D K++IW+    +  +P   +D HT  + C+S
Sbjct: 186 TIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLS 245

Query: 188 FNTDGS-LLTTTCKDKKLRVIEPRSGRV-LQEANCKNHRVNRVVFLGNMKRLLTTGVSRW 245
           FN     +L T   DK + + + R+ ++ L         + +V +  + + +L    S  
Sbjct: 246 FNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL---ASSG 302

Query: 246 NTRQIALWDQEDLSMPLIEEEI-DGLSGLLF 275
             R++ +WD   +      E+  DG   LLF
Sbjct: 303 TDRRLNVWDLSKIGEEQSPEDAEDGPPELLF 333



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 20/89 (22%), Positives = 46/89 (51%), Gaps = 7/89 (7%)

Query: 86  HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEA------LLELHG-HSR 138
           H+  +  ++W+P  + I+AS   D  + +W++ + G +++  +A      LL +HG H+ 
Sbjct: 281 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTA 340

Query: 139 RVGLVEWHPTTNNILFSAGYDYKVLIWNL 167
           ++    W+P    ++ S   D  + +W +
Sbjct: 341 KISDFSWNPNEPWVICSVSEDNIMQVWQM 369



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 13/35 (37%), Positives = 20/35 (57%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPE 119
           GH   + D  WNP    +I S SED  +++W++ E
Sbjct: 337 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 371


>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
           sapiens]
          Length = 424

 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 51/211 (24%), Positives = 96/211 (45%), Gaps = 10/211 (4%)

Query: 71  EQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEAL 130
           + +G   P+  ++ GHQ     + WNP +   + S S+D ++ +W+I     +  + +A 
Sbjct: 161 DPSGECNPDL-RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAK 219

Query: 131 LELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNL---DVGEPVKMIDCHTDVILCMS 187
               GH+  V  V WH    ++  S   D K++IW+    +  +P   +D HT  + C+S
Sbjct: 220 TIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLS 279

Query: 188 FNTDGS-LLTTTCKDKKLRVIEPRSGRV-LQEANCKNHRVNRVVFLGNMKRLLTTGVSRW 245
           FN     +L T   DK + + + R+ ++ L         + +V +  + + +L    S  
Sbjct: 280 FNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL---ASSG 336

Query: 246 NTRQIALWDQEDLSMPLIEEEI-DGLSGLLF 275
             R++ +WD   +      E+  DG   LLF
Sbjct: 337 TDRRLNVWDLSKIGEEQSPEDAEDGPPELLF 367



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 20/89 (22%), Positives = 46/89 (51%), Gaps = 7/89 (7%)

Query: 86  HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEA------LLELHG-HSR 138
           H+  +  ++W+P  + I+AS   D  + +W++ + G +++  +A      LL +HG H+ 
Sbjct: 315 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTA 374

Query: 139 RVGLVEWHPTTNNILFSAGYDYKVLIWNL 167
           ++    W+P    ++ S   D  + +W +
Sbjct: 375 KISDFSWNPNEPWVICSVSEDNIMQVWQM 403



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 13/35 (37%), Positives = 20/35 (57%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPE 119
           GH   + D  WNP    +I S SED  +++W++ E
Sbjct: 371 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 405


>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
           sapiens]
          Length = 425

 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 51/211 (24%), Positives = 96/211 (45%), Gaps = 10/211 (4%)

Query: 71  EQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEAL 130
           + +G   P+  ++ GHQ     + WNP +   + S S+D ++ +W+I     +  + +A 
Sbjct: 162 DPSGECNPDL-RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAK 220

Query: 131 LELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNL---DVGEPVKMIDCHTDVILCMS 187
               GH+  V  V WH    ++  S   D K++IW+    +  +P   +D HT  + C+S
Sbjct: 221 TIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLS 280

Query: 188 FNTDGS-LLTTTCKDKKLRVIEPRSGRV-LQEANCKNHRVNRVVFLGNMKRLLTTGVSRW 245
           FN     +L T   DK + + + R+ ++ L         + +V +  + + +L    S  
Sbjct: 281 FNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL---ASSG 337

Query: 246 NTRQIALWDQEDLSMPLIEEEI-DGLSGLLF 275
             R++ +WD   +      E+  DG   LLF
Sbjct: 338 TDRRLNVWDLSKIGEEQSPEDAEDGPPELLF 368



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 20/89 (22%), Positives = 46/89 (51%), Gaps = 7/89 (7%)

Query: 86  HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEA------LLELHG-HSR 138
           H+  +  ++W+P  + I+AS   D  + +W++ + G +++  +A      LL +HG H+ 
Sbjct: 316 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTA 375

Query: 139 RVGLVEWHPTTNNILFSAGYDYKVLIWNL 167
           ++    W+P    ++ S   D  + +W +
Sbjct: 376 KISDFSWNPNEPWVICSVSEDNIMQVWQM 404



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 13/35 (37%), Positives = 20/35 (57%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPE 119
           GH   + D  WNP    +I S SED  +++W++ E
Sbjct: 372 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 36/139 (25%), Positives = 71/139 (51%), Gaps = 16/139 (11%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVE 144
           GH   V  IKW+P    ++ASCS+D +++IW + +          + +L  H++ +  ++
Sbjct: 359 GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQ-------EVCIHDLQAHNKEIYTIK 410

Query: 145 WHPT--------TNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLT 196
           W PT        +N +L SA +D  V +W+++ G     +  H + +  ++F+ DG  L 
Sbjct: 411 WSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLA 470

Query: 197 TTCKDKKLRVIEPRSGRVL 215
           +   DK + +   +SG ++
Sbjct: 471 SGSFDKCVHIWNTQSGNLV 489



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 41/159 (25%), Positives = 71/159 (44%), Gaps = 13/159 (8%)

Query: 69  PLEQTGRIEPNYPKVC---GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPE---GGL 122
           P+E  G +E    K     GH+  V    WNP + +++AS S D++ RIW + E   GG 
Sbjct: 160 PMEIDGEVEIPSSKATVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGS 218

Query: 123 KRNMTEALLELHGH----SRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDC 178
            + +    +   GH    ++ V  ++W+ T   +L +  YD    IW  D G     +  
Sbjct: 219 TQLVLRHCIREGGHDVPSNKDVTSLDWN-TNGTLLATGSYDGFARIWTED-GNLASTLGQ 276

Query: 179 HTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQE 217
           H   I  + +N  G+ + +   DK   + +  +G   Q+
Sbjct: 277 HKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQ 315



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 35/141 (24%), Positives = 56/141 (39%), Gaps = 12/141 (8%)

Query: 86  HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEW 145
           H+G +  +KWN    N I S   D +  IW+   G       EA  +   HS     V+W
Sbjct: 277 HKGPIFALKWNRK-GNYILSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 328

Query: 146 HPTTNNILF-SAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKL 204
               NN  F S   D  + +  L    PVK    HT+ +  + ++  G LL +   D  L
Sbjct: 329 Q---NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 385

Query: 205 RVIEPRSGRVLQEANCKNHRV 225
           ++   +    + +    N  +
Sbjct: 386 KIWSMKQEVCIHDLQAHNKEI 406


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 36/139 (25%), Positives = 71/139 (51%), Gaps = 16/139 (11%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVE 144
           GH   V  IKW+P    ++ASCS+D +++IW + +          + +L  H++ +  ++
Sbjct: 359 GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQ-------EVCIHDLQAHNKEIYTIK 410

Query: 145 WHPT--------TNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLT 196
           W PT        +N +L SA +D  V +W+++ G     +  H + +  ++F+ DG  L 
Sbjct: 411 WSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLA 470

Query: 197 TTCKDKKLRVIEPRSGRVL 215
           +   DK + +   +SG ++
Sbjct: 471 SGSFDKCVHIWNTQSGNLV 489



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 41/159 (25%), Positives = 71/159 (44%), Gaps = 13/159 (8%)

Query: 69  PLEQTGRIEPNYPKVC---GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPE---GGL 122
           P+E  G +E    K     GH+  V    WNP + +++AS S D++ RIW + E   GG 
Sbjct: 160 PMEIDGEVEIPSSKATVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGS 218

Query: 123 KRNMTEALLELHGH----SRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDC 178
            + +    +   GH    ++ V  ++W+ T   +L +  YD    IW  D G     +  
Sbjct: 219 TQLVLRHCIREGGHDVPSNKDVTSLDWN-TNGTLLATGSYDGFARIWTED-GNLASTLGQ 276

Query: 179 HTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQE 217
           H   I  + +N  G+ + +   DK   + +  +G   Q+
Sbjct: 277 HKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQ 315



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 35/141 (24%), Positives = 56/141 (39%), Gaps = 12/141 (8%)

Query: 86  HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEW 145
           H+G +  +KWN    N I S   D +  IW+   G       EA  +   HS     V+W
Sbjct: 277 HKGPIFALKWNRK-GNYILSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 328

Query: 146 HPTTNNILF-SAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKL 204
               NN  F S   D  + +  L    PVK    HT+ +  + ++  G LL +   D  L
Sbjct: 329 Q---NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 385

Query: 205 RVIEPRSGRVLQEANCKNHRV 225
           ++   +    + +    N  +
Sbjct: 386 KIWSMKQEVCIHDLQAHNKEI 406


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 36/139 (25%), Positives = 71/139 (51%), Gaps = 16/139 (11%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVE 144
           GH   V  IKW+P    ++ASCS+D +++IW + +          + +L  H++ +  ++
Sbjct: 410 GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQ-------EVCIHDLQAHNKEIYTIK 461

Query: 145 WHPT--------TNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLT 196
           W PT        +N +L SA +D  V +W+++ G     +  H + +  ++F+ DG  L 
Sbjct: 462 WSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLA 521

Query: 197 TTCKDKKLRVIEPRSGRVL 215
           +   DK + +   +SG ++
Sbjct: 522 SGSFDKCVHIWNTQSGNLV 540



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 41/159 (25%), Positives = 71/159 (44%), Gaps = 13/159 (8%)

Query: 69  PLEQTGRIEPNYPKVC---GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPE---GGL 122
           P+E  G +E    K     GH+  V    WNP + +++AS S D++ RIW + E   GG 
Sbjct: 211 PMEIDGEVEIPSSKATVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGS 269

Query: 123 KRNMTEALLELHGH----SRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDC 178
            + +    +   GH    ++ V  ++W+ T   +L +  YD    IW  D G     +  
Sbjct: 270 TQLVLRHCIREGGHDVPSNKDVTSLDWN-TNGTLLATGSYDGFARIWTED-GNLASTLGQ 327

Query: 179 HTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQE 217
           H   I  + +N  G+ + +   DK   + +  +G   Q+
Sbjct: 328 HKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQ 366



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 35/141 (24%), Positives = 56/141 (39%), Gaps = 12/141 (8%)

Query: 86  HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEW 145
           H+G +  +KWN    N I S   D +  IW+   G       EA  +   HS     V+W
Sbjct: 328 HKGPIFALKWNRK-GNYILSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 379

Query: 146 HPTTNNILF-SAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKL 204
               NN  F S   D  + +  L    PVK    HT+ +  + ++  G LL +   D  L
Sbjct: 380 Q---NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 436

Query: 205 RVIEPRSGRVLQEANCKNHRV 225
           ++   +    + +    N  +
Sbjct: 437 KIWSMKQEVCIHDLQAHNKEI 457


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 36/139 (25%), Positives = 71/139 (51%), Gaps = 16/139 (11%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVE 144
           GH   V  IKW+P    ++ASCS+D +++IW + +          + +L  H++ +  ++
Sbjct: 410 GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQ-------EVCIHDLQAHNKEIYTIK 461

Query: 145 WHPT--------TNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLT 196
           W PT        +N +L SA +D  V +W+++ G     +  H + +  ++F+ DG  L 
Sbjct: 462 WSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLA 521

Query: 197 TTCKDKKLRVIEPRSGRVL 215
           +   DK + +   +SG ++
Sbjct: 522 SGSFDKCVHIWNTQSGNLV 540



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 41/159 (25%), Positives = 71/159 (44%), Gaps = 13/159 (8%)

Query: 69  PLEQTGRIEPNYPKVC---GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPE---GGL 122
           P+E  G +E    K     GH+  V    WNP + +++AS S D++ RIW + E   GG 
Sbjct: 211 PMEIDGEVEIPSSKATVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGS 269

Query: 123 KRNMTEALLELHGH----SRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDC 178
            + +    +   GH    ++ V  ++W+ T   +L +  YD    IW  D G     +  
Sbjct: 270 TQLVLRHCIREGGHDVPSNKDVTSLDWN-TNGTLLATGSYDGFARIWTED-GNLASTLGQ 327

Query: 179 HTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQE 217
           H   I  + +N  G+ + +   DK   + +  +G   Q+
Sbjct: 328 HKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQ 366



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 35/141 (24%), Positives = 56/141 (39%), Gaps = 12/141 (8%)

Query: 86  HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEW 145
           H+G +  +KWN    N I S   D +  IW+   G       EA  +   HS     V+W
Sbjct: 328 HKGPIFALKWNRK-GNYILSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 379

Query: 146 HPTTNNILF-SAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKL 204
               NN  F S   D  + +  L    PVK    HT+ +  + ++  G LL +   D  L
Sbjct: 380 Q---NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 436

Query: 205 RVIEPRSGRVLQEANCKNHRV 225
           ++   +    + +    N  +
Sbjct: 437 KIWSMKQEVCIHDLQAHNKEI 457


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 38/139 (27%), Positives = 72/139 (51%), Gaps = 16/139 (11%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVE 144
           GH   V  IKW+P    ++ASCS+D +++IW + +          + +L  HS+ +  ++
Sbjct: 357 GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQDA-------CVHDLQAHSKEIYTIK 408

Query: 145 WHPT---TNN-----ILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLT 196
           W PT   T+N     +L SA +D  V +W+++ G     +  H + +  ++F+ DG  L 
Sbjct: 409 WSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLA 468

Query: 197 TTCKDKKLRVIEPRSGRVL 215
           +   DK + +   +SG ++
Sbjct: 469 SGSFDKYVHIWNTQSGSLV 487



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 41/159 (25%), Positives = 72/159 (45%), Gaps = 13/159 (8%)

Query: 69  PLEQTGRIE--PNYPKVC-GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPE---GGL 122
           P+E  G +E  PN   V  GH+  V    WNP + +++AS S D++ RIW + E   GG 
Sbjct: 158 PMEIDGDVEIPPNKATVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGS 216

Query: 123 KRNMTEALLELHGH----SRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDC 178
            + +    +   GH    ++ V  ++W+ +   +L    YD    IW  + G     +  
Sbjct: 217 TQLVLRHCIREGGHDVPSNKDVTSLDWN-SDGTLLAMGSYDGFARIWT-ENGNLASTLGQ 274

Query: 179 HTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQE 217
           H   I  + +N  G+ + +   DK   + +  +G   Q+
Sbjct: 275 HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQ 313



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 33/122 (27%), Positives = 52/122 (42%), Gaps = 12/122 (9%)

Query: 86  HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEW 145
           H+G +  +KWN    N + S   D +  IW+   G       EA  +   HS     V+W
Sbjct: 275 HKGPIFALKWNKK-GNYVLSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 326

Query: 146 HPTTNNILF-SAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKL 204
               NN+ F S   D  + +  L    PVK    HT+ +  + ++  G LL +   D  L
Sbjct: 327 Q---NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 383

Query: 205 RV 206
           ++
Sbjct: 384 KI 385


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 38/139 (27%), Positives = 72/139 (51%), Gaps = 16/139 (11%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVE 144
           GH   V  IKW+P    ++ASCS+D +++IW + +          + +L  HS+ +  ++
Sbjct: 357 GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQDA-------CVHDLQAHSKEIYTIK 408

Query: 145 WHPT---TNN-----ILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLT 196
           W PT   T+N     +L SA +D  V +W+++ G     +  H + +  ++F+ DG  L 
Sbjct: 409 WSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLA 468

Query: 197 TTCKDKKLRVIEPRSGRVL 215
           +   DK + +   +SG ++
Sbjct: 469 SGSFDKYVHIWNTQSGSLV 487



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 41/159 (25%), Positives = 72/159 (45%), Gaps = 13/159 (8%)

Query: 69  PLEQTGRIE--PNYPKVC-GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPE---GGL 122
           P+E  G +E  PN   V  GH+  V    WNP + +++AS S D++ RIW + E   GG 
Sbjct: 158 PMEIDGDVEIPPNKATVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGS 216

Query: 123 KRNMTEALLELHGH----SRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDC 178
            + +    +   GH    ++ V  ++W+ +   +L    YD    IW  + G     +  
Sbjct: 217 TQLVLRHCIREGGHDVPSNKDVTSLDWN-SDGTLLAMGSYDGFARIWT-ENGNLASTLGQ 274

Query: 179 HTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQE 217
           H   I  + +N  G+ + +   DK   + +  +G   Q+
Sbjct: 275 HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQ 313



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 33/122 (27%), Positives = 52/122 (42%), Gaps = 12/122 (9%)

Query: 86  HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEW 145
           H+G +  +KWN    N + S   D +  IW+   G       EA  +   HS     V+W
Sbjct: 275 HKGPIFALKWNKK-GNYVLSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 326

Query: 146 HPTTNNILF-SAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKL 204
               NN+ F S   D  + +  L    PVK    HT+ +  + ++  G LL +   D  L
Sbjct: 327 Q---NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 383

Query: 205 RV 206
           ++
Sbjct: 384 KI 385


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 38/139 (27%), Positives = 72/139 (51%), Gaps = 16/139 (11%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVE 144
           GH   V  IKW+P    ++ASCS+D +++IW + +          + +L  HS+ +  ++
Sbjct: 357 GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQDA-------CVHDLQAHSKEIYTIK 408

Query: 145 WHPT---TNN-----ILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLT 196
           W PT   T+N     +L SA +D  V +W+++ G     +  H + +  ++F+ DG  L 
Sbjct: 409 WSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLA 468

Query: 197 TTCKDKKLRVIEPRSGRVL 215
           +   DK + +   +SG ++
Sbjct: 469 SGSFDKYVHIWNTQSGSLV 487



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 41/159 (25%), Positives = 72/159 (45%), Gaps = 13/159 (8%)

Query: 69  PLEQTGRIE--PNYPKVC-GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPE---GGL 122
           P+E  G +E  PN   V  GH+  V    WNP + +++AS S D++ RIW + E   GG 
Sbjct: 158 PMEIDGDVEIPPNKATVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGS 216

Query: 123 KRNMTEALLELHGH----SRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDC 178
            + +    +   GH    ++ V  ++W+ +   +L    YD    IW  + G     +  
Sbjct: 217 TQLVLRHCIREGGHDVPSNKDVTSLDWN-SDGTLLAMGSYDGFARIWT-ENGNLASTLGQ 274

Query: 179 HTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQE 217
           H   I  + +N  G+ + +   DK   + +  +G   Q+
Sbjct: 275 HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQ 313



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 33/122 (27%), Positives = 52/122 (42%), Gaps = 12/122 (9%)

Query: 86  HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEW 145
           H+G +  +KWN    N + S   D +  IW+   G       EA  +   HS     V+W
Sbjct: 275 HKGPIFALKWNKK-GNYVLSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 326

Query: 146 HPTTNNILF-SAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKL 204
               NN+ F S   D  + +  L    PVK    HT+ +  + ++  G LL +   D  L
Sbjct: 327 Q---NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 383

Query: 205 RV 206
           ++
Sbjct: 384 KI 385


>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
           sapiens]
          Length = 421

 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 61/249 (24%), Positives = 112/249 (44%), Gaps = 17/249 (6%)

Query: 86  HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEW 145
           H   V D+ + P    I+ S S D ++R+W++ + G   NM + L    GH   V    +
Sbjct: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDG---NMMKVL---RGHQNWVYSCAF 222

Query: 146 HPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLR 205
            P ++ +L S G    V +WN+D    ++ ++ H   ++   F+ DG+LL T   D ++ 
Sbjct: 223 SPDSS-MLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVY 281

Query: 206 VIEPRSGRVLQEANCKNHRVNRVVFLG--NMKRLLTTGVSRWNTRQIALWDQEDLSMPLI 263
           + +P +G +L E           +F G  N + + +   S       +L D + +    I
Sbjct: 282 IWDPHNGDILMEFG-HLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340

Query: 264 EE----EIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTEKPYLSYL--MEFRSPA 317
           +E    ++  LS  L   +  D  +L  AG  DG++ ++    + P L +L  M  R   
Sbjct: 341 DEDYPVQVAPLSNGLCCAFSTDGSVL-AAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVM 399

Query: 318 PQKGLGVMP 326
           P + +  +P
Sbjct: 400 PTQEVQELP 408



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 31/124 (25%), Positives = 62/124 (50%), Gaps = 10/124 (8%)

Query: 143 VEWHPTT---NNILFSAGYDY-KVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSL-LTT 197
           +EWH      + +L + G +  ++ IW++  G+ +  +  HT+V+  ++F  DGSL L +
Sbjct: 129 IEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVS 188

Query: 198 TCKDKKLRVIEPR-SGRVLQEANCKNHRVNRVVFLGNMKRLLTTGVSRWNTRQIALWDQE 256
             +DK LRV + +  G +++      + V    F  +   L + G S    + + LW+ +
Sbjct: 189 ASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGAS----KAVFLWNMD 244

Query: 257 DLSM 260
             +M
Sbjct: 245 KYTM 248


>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
           sapiens]
          Length = 275

 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 61/249 (24%), Positives = 112/249 (44%), Gaps = 17/249 (6%)

Query: 86  HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEW 145
           H   V D+ + P    I+ S S D ++R+W++ + G   NM + L    GH   V    +
Sbjct: 23  HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDG---NMMKVL---RGHQNWVYSCAF 76

Query: 146 HPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLR 205
            P ++ +L S G    V +WN+D    ++ ++ H   ++   F+ DG+LL T   D ++ 
Sbjct: 77  SPDSS-MLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVY 135

Query: 206 VIEPRSGRVLQEANCKNHRVNRVVFLG--NMKRLLTTGVSRWNTRQIALWDQEDLSMPLI 263
           + +P +G +L E           +F G  N + + +   S       +L D + +    I
Sbjct: 136 IWDPHNGDILMEFG-HLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 194

Query: 264 EE----EIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTEKPYLSYL--MEFRSPA 317
           +E    ++  LS  L   +  D  +L  AG  DG++ ++    + P L +L  M  R   
Sbjct: 195 DEDYPVQVAPLSNGLCCAFSTDGSVL-AAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVM 253

Query: 318 PQKGLGVMP 326
           P + +  +P
Sbjct: 254 PTQEVQELP 262



 Score = 32.7 bits (73), Expect = 0.75
 Identities = 24/95 (25%), Positives = 48/95 (50%), Gaps = 6/95 (6%)

Query: 168 DVGEPVKMIDCHTDVILCMSFNTDGSL-LTTTCKDKKLRVIEPR-SGRVLQEANCKNHRV 225
           ++G+ +  +  HT+V+  ++F  DGSL L +  +DK LRV + +  G +++      + V
Sbjct: 12  EIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWV 71

Query: 226 NRVVFLGNMKRLLTTGVSRWNTRQIALWDQEDLSM 260
               F  +   L + G S    + + LW+ +  +M
Sbjct: 72  YSCAFSPDSSMLCSVGAS----KAVFLWNMDKYTM 102


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 35/129 (27%), Positives = 68/129 (52%), Gaps = 9/129 (6%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVE 144
           GH   ++ + +NP    ++A+ S DT+ ++W+I  G       E +  L GHS  +  + 
Sbjct: 175 GHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQNG-------EEVYTLRGHSAEIISLS 226

Query: 145 WHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKL 204
           ++ T+ + + +  +D+ V++W+ D G  V ++  H   I   SFN D SL+ T   DK  
Sbjct: 227 FN-TSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 285

Query: 205 RVIEPRSGR 213
           ++ +  +G+
Sbjct: 286 KLWDATNGK 294



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 31/122 (25%), Positives = 61/122 (50%), Gaps = 9/122 (7%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVE 144
           GH   +LD  ++ +   +IA+ S D + RI+            + + +L GH   +  + 
Sbjct: 301 GHDDEILDSCFD-YTGKLIATASADGTARIFSAAT-------RKCIAKLEGHEGEISKIS 352

Query: 145 WHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKL 204
           ++P  N++L  +  D    IW+   G+ +++++ HTD I   +FN  G+++ T  KD   
Sbjct: 353 FNPQGNHLLTGSS-DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTC 411

Query: 205 RV 206
           R+
Sbjct: 412 RI 413



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 46/221 (20%), Positives = 89/221 (40%), Gaps = 17/221 (7%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVE 144
           GH+  V  I +N    + IA+ S D + ++W +  G       +      GH+  +  + 
Sbjct: 132 GHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG-------KCYHTFRGHTAEIVCLS 184

Query: 145 WHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKL 204
           ++P  + ++ +   D    +W++  GE V  +  H+  I+ +SFNT G  + T   D  +
Sbjct: 185 FNP-QSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTV 243

Query: 205 RVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTTGVSRWNTRQIALWDQED-LSMPLI 263
            V +  +GR +         ++   F  +   +LT  +     +   LWD  +   +  +
Sbjct: 244 VVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMD----KTCKLWDATNGKCVATL 299

Query: 264 EEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTEK 304
               D +    F +    T  L      DG  R +  +T K
Sbjct: 300 TGHDDEILDSCFDY----TGKLIATASADGTARIFSAATRK 336



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 29/150 (19%), Positives = 64/150 (42%), Gaps = 11/150 (7%)

Query: 107 SEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWN 166
           S D + ++W+   G       E L  L GH   V  + ++    + + +  +D    +W+
Sbjct: 111 SYDRTCKLWDTASG-------EELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWS 163

Query: 167 LDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVN 226
           ++ G+       HT  I+C+SFN   +L+ T   D   ++ + ++G  +      +  + 
Sbjct: 164 VETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEII 223

Query: 227 RVVFLGNMKRLLTTGVSRWNTRQIALWDQE 256
            + F  +  R++T          + +WD +
Sbjct: 224 SLSFNTSGDRIITGSFD----HTVVVWDAD 249



 Score = 32.7 bits (73), Expect = 0.75
 Identities = 22/84 (26%), Positives = 39/84 (46%), Gaps = 9/84 (10%)

Query: 82  KVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVG 141
           K+ GH+G +  I +NP  ++++   S D + RIW+   G       + L  L GH+  + 
Sbjct: 340 KLEGHEGEISKISFNPQGNHLLTG-SSDKTARIWDAQTG-------QCLQVLEGHTDEIF 391

Query: 142 LVEWHPTTNNILFSAGYDYKVLIW 165
              ++    NI+ +   D    IW
Sbjct: 392 SCAFN-YKGNIVITGSKDNTCRIW 414



 Score = 30.4 bits (67), Expect = 3.7
 Identities = 28/116 (24%), Positives = 46/116 (39%), Gaps = 12/116 (10%)

Query: 147 PTTNNILFSAG-------YDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTD-GSLLTTT 198
           P TN  L  +G       YD    +W+   GE +  ++ H +V+  ++FN   G  + T 
Sbjct: 94  PLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATG 153

Query: 199 CKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTTGVSRWNTRQIALWD 254
             DK  ++    +G+       + H    V    N +  L    S   T +  LWD
Sbjct: 154 SFDKTCKLWSVETGKCYH--TFRGHTAEIVCLSFNPQSTLVATGSMDTTAK--LWD 205


>gi|7706657 cell division cycle 40 homolog [Homo sapiens]
          Length = 579

 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 45/173 (26%), Positives = 83/173 (47%), Gaps = 15/173 (8%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVE 144
           GH   V  ++  P   +++ SCS D  +++WE+   G +R     L    GHS+ V  + 
Sbjct: 286 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV--YGERR----CLRTFIGHSKAVRDIC 339

Query: 145 WHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTD---GSLLTTTCKD 201
           ++ T      SA YD  + +W+ + G+ +     +  V  C+ FN D    +L      D
Sbjct: 340 FN-TAGTQFLSAAYDRYLKLWDTETGQCISRF-TNRKVPYCVKFNPDEDKQNLFVAGMSD 397

Query: 202 KKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTTGVSRWNTRQIALWD 254
           KK+   + RSG ++QE +     VN +VF+   +R ++T     + + + +W+
Sbjct: 398 KKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS----DDKSLRVWE 446


>gi|4757988 WD repeat domain 39 [Homo sapiens]
          Length = 339

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 36/124 (29%), Positives = 64/124 (51%), Gaps = 8/124 (6%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVE 144
           GH+  V  + W P   N++A+CS D SV +WE+ E     +  E +  L+ H++ V  V 
Sbjct: 103 GHENEVKSVAWAPS-GNLLATCSRDKSVWVWEVDE----EDEYECVSVLNSHTQDVKHVV 157

Query: 145 WHPTTNNILFSAGYDYKVLIWNLDVGEPV--KMIDCHTDVILCMSFNTDGSLLTTTCKDK 202
           WHP +  +L SA YD  V ++  +  + V    ++ H   +  ++F+  G  L +   D+
Sbjct: 158 WHP-SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDR 216

Query: 203 KLRV 206
            +R+
Sbjct: 217 TVRI 220



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 38/118 (32%), Positives = 57/118 (48%), Gaps = 8/118 (6%)

Query: 93  IKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEWHPTTNNI 152
           + WNP    ++ASC  D  +RIW          + +++L   GH R V  V W P   N 
Sbjct: 22  LAWNP-AGTLLASCGGDRRIRIWGTEGDSW---ICKSVLS-EGHQRTVRKVAWSPC-GNY 75

Query: 153 LFSAGYDYKVLIW--NLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIE 208
           L SA +D    IW  N D  E V  ++ H + +  +++   G+LL T  +DK + V E
Sbjct: 76  LASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133



 Score = 37.7 bits (86), Expect = 0.023
 Identities = 23/94 (24%), Positives = 37/94 (39%), Gaps = 5/94 (5%)

Query: 77  EPNYPKVCG----HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLE 132
           +P++  +C     H   + DI W      +  +C +D      E P    ++        
Sbjct: 238 DPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAH 297

Query: 133 LH-GHSRRVGLVEWHPTTNNILFSAGYDYKVLIW 165
           LH  HS+ V  V W+P    +L S   D +V  W
Sbjct: 298 LHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFW 331



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 32/135 (23%), Positives = 59/135 (43%), Gaps = 20/135 (14%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMT--------EALLELHG- 135
           GH+  V  + ++P    + ASCS+D +VRIW     G ++ +         + +  L G 
Sbjct: 192 GHESTVWSLAFDPSGQRL-ASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGF 250

Query: 136 HSRRVGLVEWHPTTNNILFSAGYDYKVLIW----NLDVGEP-----VKMIDCHTDVILCM 186
           HSR +  + W   T  +  + G D  + ++    N D  +P       +   H+  + C+
Sbjct: 251 HSRTIYDIAWCQLTGALATACG-DDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCV 309

Query: 187 SFNTDGSLLTTTCKD 201
           ++N     L  +C D
Sbjct: 310 AWNPKEPGLLASCSD 324



 Score = 33.1 bits (74), Expect = 0.57
 Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 2/37 (5%)

Query: 86  HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEI--PEG 120
           H  +V  + WNP    ++ASCS+D  V  W+   PEG
Sbjct: 302 HSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRPEG 338


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 42/138 (30%), Positives = 69/138 (50%), Gaps = 15/138 (10%)

Query: 85  GHQGNVLDIKWNPFI-------DNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHS 137
           GH  NV  I ++P         D  +ASC+ D SV++W +       +  E + ++ GH+
Sbjct: 271 GHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSL-------DSDEPVADIEGHT 323

Query: 138 RRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTT 197
            RV  V WHP+    L +  YD    +W+L+  E +   + H+  +  ++F+ DGSL  T
Sbjct: 324 VRVARVMWHPS-GRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGT 382

Query: 198 TCKDKKLRVIEPRSGRVL 215
              D   RV + R+GR +
Sbjct: 383 GGLDAFGRVWDLRTGRCI 400



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 37/132 (28%), Positives = 59/132 (44%), Gaps = 16/132 (12%)

Query: 84  CGHQGNVLDIKWNPFIDN--IIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVG 141
           C   G+   I +  F  N  ++A+       ++W +P+  L       L  L GH+  VG
Sbjct: 225 CSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNL-------LHTLRGHNTNVG 277

Query: 142 LVEWHPTTNNIL-------FSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSL 194
            + +HP +   L        S   D  V +W+LD  EPV  I+ HT  +  + ++  G  
Sbjct: 278 AIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRF 337

Query: 195 LTTTCKDKKLRV 206
           L TTC D+  R+
Sbjct: 338 LGTTCYDRSWRL 349



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 8/122 (6%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVE 144
           GH   +  I ++P   +I A+ S D + ++W++ +          +  +  H   V  V+
Sbjct: 405 GHLKEIYGINFSPNGYHI-ATGSGDNTCKVWDLRQ-------RRCVYTIPAHQNLVTGVK 456

Query: 145 WHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKL 204
           + P   N L +  YD    IW      P+K +  H   ++ +  ++DG L+ T   D+  
Sbjct: 457 FEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTF 516

Query: 205 RV 206
           ++
Sbjct: 517 KL 518



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 36/157 (22%), Positives = 63/157 (40%), Gaps = 9/157 (5%)

Query: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVE 144
           GH   V  + W+P     + +   D S R+W++          E +L   GHS  V  + 
Sbjct: 321 GHTVRVARVMWHPS-GRFLGTTCYDRSWRLWDL-------EAQEEILHQEGHSMGVYDIA 372

Query: 145 WHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKL 204
           +H    ++  + G D    +W+L  G  +  ++ H   I  ++F+ +G  + T   D   
Sbjct: 373 FHQD-GSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTC 431

Query: 205 RVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTTG 241
           +V + R  R +       + V  V F       L TG
Sbjct: 432 KVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTG 468


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,981,928
Number of Sequences: 37866
Number of extensions: 858171
Number of successful extensions: 3592
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 123
Number of HSP's successfully gapped in prelim test: 124
Number of HSP's that attempted gapping in prelim test: 2667
Number of HSP's gapped (non-prelim): 701
length of query: 480
length of database: 18,247,518
effective HSP length: 106
effective length of query: 374
effective length of database: 14,233,722
effective search space: 5323412028
effective search space used: 5323412028
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.