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Search of human proteins with 14602457
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14602457 transmembrane protease, serine 3 isoform 3 [Homo
sapiens]
(344 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14602457 transmembrane protease, serine 3 isoform 3 [Homo sap... 707 0.0
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap... 656 0.0
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa... 186 3e-47
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa... 186 3e-47
gi|116256363 transmembrane protease, serine 13 [Homo sapiens] 142 3e-34
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap... 137 1e-32
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa... 133 2e-31
gi|170932492 transmembrane protease, serine 5 [Homo sapiens] 123 2e-28
gi|223942069 enterokinase precursor [Homo sapiens] 119 4e-27
gi|33695155 hepsin [Homo sapiens] 110 2e-24
gi|4504481 hepsin [Homo sapiens] 110 2e-24
gi|29244926 corin [Homo sapiens] 108 7e-24
gi|205360905 testis-specific serine protease 1 [Homo sapiens] 95 1e-19
gi|187761337 transmembrane protease, serine 11B [Homo sapiens] 93 3e-19
gi|148806900 epidermis-specific serine protease-like protein [Ho... 92 9e-19
gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ... 91 1e-18
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens] 91 1e-18
gi|4506143 neurotrypsin precursor [Homo sapiens] 89 6e-18
gi|110815798 ovochymase 1 [Homo sapiens] 89 7e-18
gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo ... 88 1e-17
gi|117956391 protease, serine, 33 [Homo sapiens] 86 4e-17
gi|40254871 transmembrane protease, serine 11E [Homo sapiens] 86 5e-17
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens] 86 5e-17
gi|4506153 prostasin preproprotein [Homo sapiens] 85 1e-16
gi|4758508 transmembrane protease, serine 11D [Homo sapiens] 84 1e-16
gi|222831592 transmembrane protease, serine 7 [Homo sapiens] 83 4e-16
gi|4503627 coagulation factor XI precursor [Homo sapiens] 82 5e-16
gi|21614531 testisin isoform 2 [Homo sapiens] 82 5e-16
gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 82 7e-16
gi|58218970 protease, serine, 36 [Homo sapiens] 82 7e-16
>gi|14602457 transmembrane protease, serine 3 isoform 3 [Homo
sapiens]
Length = 344
Score = 707 bits (1824), Expect = 0.0
Identities = 344/344 (100%), Positives = 344/344 (100%)
Query: 1 MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALI 60
MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALI
Sbjct: 1 MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALI 60
Query: 61 LALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVF 120
LALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVF
Sbjct: 61 LALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVF 120
Query: 121 TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDK 180
TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDK
Sbjct: 121 TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDK 180
Query: 181 VTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYH 240
VTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYH
Sbjct: 181 VTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYH 240
Query: 241 LCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKR 300
LCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKR
Sbjct: 241 LCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKR 300
Query: 301 LGNDIALMKLAGPLTFNGTSGSLCGSAALPLFQEDLQLLIEAFL 344
LGNDIALMKLAGPLTFNGTSGSLCGSAALPLFQEDLQLLIEAFL
Sbjct: 301 LGNDIALMKLAGPLTFNGTSGSLCGSAALPLFQEDLQLLIEAFL 344
>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
sapiens]
Length = 454
Score = 656 bits (1693), Expect = 0.0
Identities = 318/324 (98%), Positives = 319/324 (98%)
Query: 1 MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALI 60
MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALI
Sbjct: 1 MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALI 60
Query: 61 LALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVF 120
LALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVF
Sbjct: 61 LALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVF 120
Query: 121 TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDK 180
TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDK
Sbjct: 121 TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDK 180
Query: 181 VTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYH 240
VTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYH
Sbjct: 181 VTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYH 240
Query: 241 LCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKR 300
LCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKR
Sbjct: 241 LCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKR 300
Query: 301 LGNDIALMKLAGPLTFNGTSGSLC 324
LGNDIALMKLAGPLTFN +C
Sbjct: 301 LGNDIALMKLAGPLTFNEMIQPVC 324
>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
sapiens]
Length = 529
Score = 186 bits (471), Expect = 3e-47
Identities = 119/285 (41%), Positives = 153/285 (53%), Gaps = 20/285 (7%)
Query: 52 IVIGIIALILALAIGLGIHF---DCSGK-YRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
+ +G + ALA GL F CS C SS CI CDGVS C GEDE RC
Sbjct: 126 LTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRC 185
Query: 108 VRVGGQNAVLQVFTAA--SWKTMCSDDWKGHYANVACAQLGFPS-YVSSDNLRVSSLEGQ 164
VR+ G N +LQV+++ SW +C DDW +Y AC +G+ + + SS + S
Sbjct: 186 VRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTS 245
Query: 165 FREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYS--SRIVGGNM 222
F + S ++ D L+HS + C+S VV+L+C ACG S SRIVGG
Sbjct: 246 FMKLNTSAGNV---DIYKKLYHS----DACSSKAVVSLRCIACGVNLNSSRQSRIVGGES 298
Query: 223 SLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCV-YDLYLPKSWTIQVGLV--SLLD 279
+L WPWQ SL Q H+CGGS+ITP WI+TAAHCV L P WT G++ S +
Sbjct: 299 ALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMF 358
Query: 280 NPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGSLC 324
A + VEK++ H Y K NDIALMKL PLTFN +C
Sbjct: 359 YGA-GYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVC 402
>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
sapiens]
Length = 492
Score = 186 bits (471), Expect = 3e-47
Identities = 119/285 (41%), Positives = 153/285 (53%), Gaps = 20/285 (7%)
Query: 52 IVIGIIALILALAIGLGIHF---DCSGK-YRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
+ +G + ALA GL F CS C SS CI CDGVS C GEDE RC
Sbjct: 89 LTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRC 148
Query: 108 VRVGGQNAVLQVFTAA--SWKTMCSDDWKGHYANVACAQLGFPS-YVSSDNLRVSSLEGQ 164
VR+ G N +LQV+++ SW +C DDW +Y AC +G+ + + SS + S
Sbjct: 149 VRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTS 208
Query: 165 FREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYS--SRIVGGNM 222
F + S ++ D L+HS + C+S VV+L+C ACG S SRIVGG
Sbjct: 209 FMKLNTSAGNV---DIYKKLYHS----DACSSKAVVSLRCIACGVNLNSSRQSRIVGGES 261
Query: 223 SLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCV-YDLYLPKSWTIQVGLV--SLLD 279
+L WPWQ SL Q H+CGGS+ITP WI+TAAHCV L P WT G++ S +
Sbjct: 262 ALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMF 321
Query: 280 NPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGSLC 324
A + VEK++ H Y K NDIALMKL PLTFN +C
Sbjct: 322 YGA-GYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVC 365
>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
Length = 567
Score = 142 bits (359), Expect = 3e-34
Identities = 90/280 (32%), Positives = 139/280 (49%), Gaps = 21/280 (7%)
Query: 53 VIGIIALILALAIGLGIHFDC----SGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCV 108
+IG + L++AL + L I F +G C + RCDGV DCK DE CV
Sbjct: 168 LIGCVLLLIALVVSLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCV 227
Query: 109 RVGGQNAVLQVFTAAS--WKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFR 166
R ++L++++ +S W +CS +W Y+ C QLGF S + + F
Sbjct: 228 RFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSF- 286
Query: 167 EEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLS 226
+ + + + +LH R C S ++LQC+ CG R + RIVGG ++ S
Sbjct: 287 -SILRYNSTIQE----SLH-----RSECPSQRYISLQCSHCG-LRAMTGRIVGGALASDS 335
Query: 227 QWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDL--YLPKSWTIQVGLVSLLDNPAPS 284
+WPWQ SL F H+CGG++I W++TAAHC + + + W + G +L P +
Sbjct: 336 KWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAA 395
Query: 285 HLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGSLC 324
+ E I+ +S Y + DIALM+L+ PLT + C
Sbjct: 396 SIAE-IIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPAC 434
>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
sapiens]
Length = 437
Score = 137 bits (346), Expect = 1e-32
Identities = 101/315 (32%), Positives = 147/315 (46%), Gaps = 42/315 (13%)
Query: 44 LPLKFFPIIVIGIIALILALA------IGLGIHFDCSGKYRCRSSFKCIELIARCDGVSD 97
+P++ F + I II +L+LA + + + D + C I CDG D
Sbjct: 24 IPMETFRKVGIPIIIALLSLASIIIVVVLIKVILD-KYYFLCGQPLHFIPRKQLCDGELD 82
Query: 98 CKDGEDEYRCV-----------RVGGQNAVLQVFTAAS--WKTMCSDDWKGHYANVACAQ 144
C GEDE CV R+ + LQV +A+ W + C D++ A AC Q
Sbjct: 83 CPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQ 142
Query: 145 LGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREG---CASGHVVT 201
+G+ S + FR + D L ++T + +R C SG +V+
Sbjct: 143 MGYSS------------KPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVS 190
Query: 202 LQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYD 261
L C ACG + + R+VGG + + WPWQ S+Q+ H+CGGS++ P W++TAAHC
Sbjct: 191 LHCLACG-KSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRK 249
Query: 262 LYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSG 321
+W ++ G L PS V KI+ NDIALMKL PLTF+GT
Sbjct: 250 HTDVFNWKVRAGSDKL--GSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVR 307
Query: 322 SLCGSAALPLFQEDL 336
+C LP F E+L
Sbjct: 308 PIC----LPFFDEEL 318
>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
sapiens]
Length = 432
Score = 133 bits (335), Expect = 2e-31
Identities = 99/315 (31%), Positives = 144/315 (45%), Gaps = 47/315 (14%)
Query: 44 LPLKFFPIIVIGIIALILALA------IGLGIHFDCSGKYRCRSSFKCIELIARCDGVSD 97
+P++ F + I II +L+LA + + + D + C I CDG D
Sbjct: 24 IPMETFRKVGIPIIIALLSLASIIIVVVLIKVILD-KYYFLCGQPLHFIPRKQLCDGELD 82
Query: 98 CKDGEDEYRCV-----------RVGGQNAVLQVFTAAS--WKTMCSDDWKGHYANVACAQ 144
C GEDE CV R+ + LQV +A+ W + C D++ A AC Q
Sbjct: 83 CPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQ 142
Query: 145 LGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREG---CASGHVVT 201
+G+ V + D L ++T + +R C SG +V+
Sbjct: 143 MGYSRAVE-----------------IGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVS 185
Query: 202 LQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYD 261
L C ACG + + R+VGG + + WPWQ S+Q+ H+CGGS++ P W++TAAHC
Sbjct: 186 LHCLACG-KSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRK 244
Query: 262 LYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSG 321
+W ++ G L PS V KI+ NDIALMKL PLTF+GT
Sbjct: 245 HTDVFNWKVRAGSDKL--GSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVR 302
Query: 322 SLCGSAALPLFQEDL 336
+C LP F E+L
Sbjct: 303 PIC----LPFFDEEL 313
>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
Length = 457
Score = 123 bits (309), Expect = 2e-28
Identities = 73/221 (33%), Positives = 109/221 (49%), Gaps = 10/221 (4%)
Query: 109 RVGGQNAVL--QVFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFR 166
R+ ++ +L QV W +C + W C LG + ++ ++
Sbjct: 113 RINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSS 172
Query: 167 EEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLS 226
+EF + L L + R C SG VV+L+C+ CG R +SRIVGG
Sbjct: 173 QEFAQLSPRLGG----FLEEAWQPRNNCTSGQVVSLRCSECG-ARPLASRIVGGQSVAPG 227
Query: 227 QWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPK--SWTIQVGLVS-LLDNPAP 283
+WPWQAS+ H CGGSV+ P W++TAAHC++ L + SW + GLVS P
Sbjct: 228 RWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQ 287
Query: 284 SHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGSLC 324
LVE+I+ H Y + D+AL++L L F+ T G++C
Sbjct: 288 GALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVC 328
>gi|223942069 enterokinase precursor [Homo sapiens]
Length = 1019
Score = 119 bits (298), Expect = 4e-27
Identities = 82/272 (30%), Positives = 132/272 (48%), Gaps = 26/272 (9%)
Query: 67 LGIHFDCSGK-YRCRSSFKCIELIARCDGVSDCKDGEDEYRCVR----VGGQNAVLQVFT 121
LGI C ++C++ +C+ L+ CDG C+DG DE CVR N +++
Sbjct: 637 LGIPEPCKADHFQCKNG-ECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRI 695
Query: 122 AASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKV 181
+ W T C+++W +N C LG S SS + S +G FV ++ PD
Sbjct: 696 QSIWHTACAENWTTQISNDVCQLLGLGSGNSSKP--IFSTDGG---PFVKLN-TAPDG-- 747
Query: 182 TALHHSVYVREGCASGHVVTLQCT--ACGHR---RGYSSRIVGGNMSLLSQWPWQASLQF 236
H + + C ++ LQC +CG + + + +IVGG+ + WPW L +
Sbjct: 748 ---HLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYY 804
Query: 237 QGYHLCGGSVITPLWIITAAHCVYDLYL-PKSWTIQVGLVSLLDNPAPS---HLVEKIVY 292
G LCG S+++ W+++AAHCVY L P WT +GL + +P L+++IV
Sbjct: 805 GGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVI 864
Query: 293 HSKYKPKRLGNDIALMKLAGPLTFNGTSGSLC 324
+ Y +R NDIA+M L + + +C
Sbjct: 865 NPHYNRRRKDNDIAMMHLEFKVNYTDYIQPIC 896
Score = 30.0 bits (66), Expect = 3.2
Identities = 15/43 (34%), Positives = 20/43 (46%), Gaps = 1/43 (2%)
Query: 63 LAIGLGIHFDC-SGKYRCRSSFKCIELIARCDGVSDCKDGEDE 104
LA + +C G C + CI+ CDG +C DG DE
Sbjct: 174 LATPGNVSIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDE 216
>gi|33695155 hepsin [Homo sapiens]
Length = 417
Score = 110 bits (275), Expect = 2e-24
Identities = 74/235 (31%), Positives = 108/235 (45%), Gaps = 21/235 (8%)
Query: 108 VRVGGQNAVLQVF--TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQF 165
V+V +A L VF T +W+ +CS A ++C ++GF ++ L V +
Sbjct: 54 VQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANG 113
Query: 166 REEFVSIDHLLPDDKVTALHHSVYVRE-----GCASGHVVTLQCTACGHRRGYSSRIVGG 220
F +D L H+ + E C G + C CG R+ RIVGG
Sbjct: 114 TSGFFCVDE-------GRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGG 166
Query: 221 NMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKS-WTIQVGLVSLLD 279
+ L +WPWQ SL++ G HLCGGS+++ W++TAAHC + S W + G V+
Sbjct: 167 RDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQAS 226
Query: 280 NPAPSHLVEKIVYHSKYKPKR------LGNDIALMKLAGPLTFNGTSGSLCGSAA 328
V+ +VYH Y P R NDIAL+ L+ PL +C AA
Sbjct: 227 PHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAA 281
>gi|4504481 hepsin [Homo sapiens]
Length = 417
Score = 110 bits (275), Expect = 2e-24
Identities = 74/235 (31%), Positives = 108/235 (45%), Gaps = 21/235 (8%)
Query: 108 VRVGGQNAVLQVF--TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQF 165
V+V +A L VF T +W+ +CS A ++C ++GF ++ L V +
Sbjct: 54 VQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANG 113
Query: 166 REEFVSIDHLLPDDKVTALHHSVYVRE-----GCASGHVVTLQCTACGHRRGYSSRIVGG 220
F +D L H+ + E C G + C CG R+ RIVGG
Sbjct: 114 TSGFFCVDE-------GRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGG 166
Query: 221 NMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKS-WTIQVGLVSLLD 279
+ L +WPWQ SL++ G HLCGGS+++ W++TAAHC + S W + G V+
Sbjct: 167 RDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQAS 226
Query: 280 NPAPSHLVEKIVYHSKYKPKR------LGNDIALMKLAGPLTFNGTSGSLCGSAA 328
V+ +VYH Y P R NDIAL+ L+ PL +C AA
Sbjct: 227 PHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAA 281
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 108 bits (270), Expect = 7e-24
Identities = 69/251 (27%), Positives = 121/251 (48%), Gaps = 16/251 (6%)
Query: 85 CIELIARCDGVSDCKDGEDEYRCVRVG---GQNAVLQVFTAASWKTMCSDDWKGHYANVA 141
C+ CDG +DC D DE+ CV + ++ L V AA+ +C+D W+ + +A
Sbjct: 667 CVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQEILSQLA 726
Query: 142 CAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVT 201
C Q+G + ++ E + ++++ T LH + + C S ++
Sbjct: 727 CKQMG----LGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSKIS 782
Query: 202 LQCTA--CGHRRG--YSSRIVGGNMSLLSQWPWQASLQFQ-GYHLCGGSVITPLWIITAA 256
L CT CG R + RI+GG S +WPWQ SLQ + H+CG +I W++T A
Sbjct: 783 LLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVA 842
Query: 257 HCVYDLYLPKSWTIQVGLVSLLDNPA---PSHLVEKIVYHSKYKPKRLGNDIALMKLAGP 313
HC W + +G ++ LD+P+ + V+ I+ H +Y + DI++++L+
Sbjct: 843 HCFEGRENAAVWKVVLG-INNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSED 901
Query: 314 LTFNGTSGSLC 324
++ G +C
Sbjct: 902 ISETGYVRPVC 912
Score = 36.6 bits (83), Expect = 0.034
Identities = 16/33 (48%), Positives = 19/33 (57%), Gaps = 1/33 (3%)
Query: 75 GKYRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
G CR+ +CI +CDG DCKDG DE C
Sbjct: 383 GLVECRNG-QCIPSTFQCDGDEDCKDGSDEENC 414
Score = 35.8 bits (81), Expect = 0.057
Identities = 16/37 (43%), Positives = 22/37 (59%), Gaps = 2/37 (5%)
Query: 72 DCS-GKYRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
+CS ++CRS +C+ RCDG +DC D DE C
Sbjct: 579 ECSPSHFKCRSG-QCVLASRRCDGQADCDDDSDEENC 614
Score = 31.6 bits (70), Expect = 1.1
Identities = 15/39 (38%), Positives = 19/39 (48%), Gaps = 2/39 (5%)
Query: 70 HFDCSGK-YRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
H +CS + C + KC+ CDG DC D DE C
Sbjct: 303 HCNCSENLFHCHTG-KCLNYSLVCDGYDDCGDLSDEQNC 340
Score = 29.3 bits (64), Expect = 5.4
Identities = 15/38 (39%), Positives = 20/38 (52%), Gaps = 3/38 (7%)
Query: 72 DCSG--KYRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
DC+ ++RC +CI + CDG DC D DE C
Sbjct: 341 DCNPTTEHRCGDG-RCIAMEWVCDGDHDCVDKSDEVNC 377
>gi|205360905 testis-specific serine protease 1 [Homo sapiens]
Length = 318
Score = 94.7 bits (234), Expect = 1e-19
Identities = 52/129 (40%), Positives = 73/129 (56%), Gaps = 16/129 (12%)
Query: 206 ACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLP 265
ACGHR ++ + GG S +WPWQASL+ + H CGGS+++ W+++AAHC Y P
Sbjct: 45 ACGHREIHAL-VAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYP 103
Query: 266 KSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYK-------PKRLG---NDIALMKLAGPLT 315
WT+Q+G L P P +L Y S+YK P LG NDIAL++LA +T
Sbjct: 104 SEWTVQLG--ELTSRPTPWNL---RAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVT 158
Query: 316 FNGTSGSLC 324
+N +C
Sbjct: 159 YNAYIQPIC 167
>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
Length = 416
Score = 93.2 bits (230), Expect = 3e-19
Identities = 48/134 (35%), Positives = 76/134 (56%), Gaps = 8/134 (5%)
Query: 195 ASGHVVTLQCTACGHRRGYS----SRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPL 250
A+ ++T C CG + S ++IV G SL WPWQAS+Q++G H CG S+I+
Sbjct: 161 AASEMLTNNC--CGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSR 218
Query: 251 WIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKL 310
W+++AAHC K WT+ G+V ++ P + V+ I++H Y L +DIAL++L
Sbjct: 219 WLLSAAHCFAKKNNSKDWTVNFGIV--VNKPYMTRKVQNIIFHENYSSPGLHDDIALVQL 276
Query: 311 AGPLTFNGTSGSLC 324
A ++F +C
Sbjct: 277 AEEVSFTEYIRKIC 290
>gi|148806900 epidermis-specific serine protease-like protein [Homo
sapiens]
Length = 328
Score = 91.7 bits (226), Expect = 9e-19
Identities = 49/133 (36%), Positives = 77/133 (57%), Gaps = 4/133 (3%)
Query: 193 GCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWI 252
GCA ++ L + CG + YSSR+VGG + +WPWQ SL F +CGGS+++ I
Sbjct: 5 GCAFTLLLLLGISVCG-QPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLI 63
Query: 253 ITAAHCVYDLYLPKSWTIQVGLVSLLDN-PAPSHLVEKIVYHSKYKPKRLGNDIALMKLA 311
+TAAHC+ + S+T+ +G +++ D+ + V KIV H KY+ D+AL+KL+
Sbjct: 64 LTAAHCIQPTWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIHPKYQDTTA--DVALLKLS 121
Query: 312 GPLTFNGTSGSLC 324
+TF +C
Sbjct: 122 SQVTFTSAILPIC 134
>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
sapiens]
Length = 418
Score = 91.3 bits (225), Expect = 1e-18
Identities = 89/315 (28%), Positives = 148/315 (46%), Gaps = 35/315 (11%)
Query: 46 LKFFPIIVIGIIAL-ILALAIGLGIHF---DCSGKYRCRSSFKCIE-LIARCDGVSDCKD 100
LK + I V+ +++L ++A+ IGL +HF D +Y SFK ++ I G S+
Sbjct: 15 LKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYY-HGSFKILDPQINNNFGQSNTYQ 73
Query: 101 GEDEYRCVRVGGQNAVLQVFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRV-- 158
+D +R +N V ++F ++WK K + N V D + V
Sbjct: 74 LKD----LRETTENLVDEIFIDSAWK-------KNYIKNQVVRLTPEEDGVKVDVIMVFQ 122
Query: 159 --SSLEGQFREEFVSIDHLLPDDKVTALH------HSVYVREGCASGHVVTLQCTACGHR 210
S+ + RE+ I +L + K+ L SV V +S +T+Q + CG R
Sbjct: 123 FPSTEQRAVREK--KIQSIL-NQKIRNLRALPINASSVQVNAMSSSTGELTVQAS-CGKR 178
Query: 211 RG--YSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSW 268
+RI G ++ + WPWQASLQ+ H CG ++I+ W++TAAHC P W
Sbjct: 179 VVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQW 238
Query: 269 TIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGSLCGSAA 328
T+ G + ++ P V + + H KY+ DIA+++++ +TF+ +C A
Sbjct: 239 TVSFG--TKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEA 296
Query: 329 LPLFQEDLQLLIEAF 343
FQ +L + I F
Sbjct: 297 SASFQPNLTVHITGF 311
>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
Length = 638
Score = 91.3 bits (225), Expect = 1e-18
Identities = 48/116 (41%), Positives = 65/116 (56%), Gaps = 5/116 (4%)
Query: 214 SSRIVGGNMSLLSQWPWQASLQFQ---GYHLCGGSVITPLWIITAAHCVYDLYLPKSWTI 270
S+RIVGG S +WPWQ SLQ + HLCGGS+I W++TAAHC L L W I
Sbjct: 388 STRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRI 447
Query: 271 QVGLVSLLD--NPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGSLC 324
G+++L D P +++I+ H YK +DIAL+KL PL + +C
Sbjct: 448 YSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPIC 503
>gi|4506143 neurotrypsin precursor [Homo sapiens]
Length = 875
Score = 89.0 bits (219), Expect = 6e-18
Identities = 73/251 (29%), Positives = 112/251 (44%), Gaps = 40/251 (15%)
Query: 117 LQVFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLL 176
++VF W T+C D W A V C QLG Y R + G+ + + +D++
Sbjct: 513 VEVFINGQWGTICDDGWTDKDAAVICRQLG---YKGPARARTMAYFGEGKGP-IHVDNVK 568
Query: 177 PDDKVTALHHSVYV---REGCASGHVVTLQC-----------------TACG----HRRG 212
+L + R C + C + CG HRR
Sbjct: 569 CTGNERSLADCIKQDIGRHNCRHSEDAGVICDYFGKKASGNSNKESLSSVCGLRLLHRR- 627
Query: 213 YSSRIVGGNMSLLSQWPWQASLQFQGYH-----LCGGSVITPLWIITAAHCVYDLY--LP 265
RI+GG SL WPWQ SL+ + H LCG ++++ W++TAAHC + Y
Sbjct: 628 -QKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHC-FKRYGNST 685
Query: 266 KSWTIQVG-LVSLLDNPAPSHL-VEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGSL 323
+S+ ++VG +L+ + V++IV H +Y+P R DIAL++L GP S
Sbjct: 686 RSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDRSDYDIALVRLQGPEEQCARFSSH 745
Query: 324 CGSAALPLFQE 334
A LPL++E
Sbjct: 746 VLPACLPLWRE 756
Score = 36.2 bits (82), Expect = 0.044
Identities = 19/55 (34%), Positives = 27/55 (49%), Gaps = 7/55 (12%)
Query: 94 GVSDCKDGEDEYRCVRVGGQN---AVLQVFTAASWKTMCSDDWKGHYANVACAQL 145
G DC+ G R GG+N ++V+ + W T+CS W A+V C QL
Sbjct: 161 GYCDCRHGSVRLR----GGKNEFEGTVEVYASGVWGTVCSSHWDDSDASVICHQL 211
Score = 34.3 bits (77), Expect = 0.17
Identities = 15/43 (34%), Positives = 24/43 (55%), Gaps = 4/43 (9%)
Query: 108 VRVGGQNAV----LQVFTAASWKTMCSDDWKGHYANVACAQLG 146
+R+ G ++V ++++ A W T+C D W A V C QLG
Sbjct: 280 IRLAGGSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLG 322
Score = 33.9 bits (76), Expect = 0.22
Identities = 14/37 (37%), Positives = 17/37 (45%)
Query: 111 GGQNAVLQVFTAASWKTMCSDDWKGHYANVACAQLGF 147
G L+V+ W T+C D W V C QLGF
Sbjct: 394 GSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGF 430
>gi|110815798 ovochymase 1 [Homo sapiens]
Length = 1134
Score = 88.6 bits (218), Expect = 7e-18
Identities = 63/216 (29%), Positives = 97/216 (44%), Gaps = 11/216 (5%)
Query: 131 DDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREE---FVSIDHLLPDDKVTALHHS 187
D + H C L S SS N+ V + + F + +LP + +
Sbjct: 483 DSEEKHKLAKLCGMLTITSIFSSSNMTVIYFKSDGKNRLQGFKARFTILPSESLNKFEPK 542
Query: 188 VYVREGCASGHVVTLQCTACG----HRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCG 243
+ + S V + CG + S RI GG + WPWQ L+F G + CG
Sbjct: 543 LPPQNNPVST-VKAILHDVCGIPPFSPQWLSRRIAGGEEACPHCWPWQVGLRFLGDYQCG 601
Query: 244 GSVITPLWIITAAHCVYDLYLPKSWTIQVG--LVSLLDNPAPSHLVEKIVYHSKYKPKRL 301
G++I P+WI+TAAHCV P SWTI G +L ++ + I+ H +
Sbjct: 602 GAIINPVWILTAAHCVQLKNNPLSWTIIAGDHDRNLKESTEQVRRAKHIIVHEDFNTLSY 661
Query: 302 GNDIALMKLAGPLTFNGTSGSLC-GSAALPLFQEDL 336
+DIAL++L+ PL +N +C +A PLF ++
Sbjct: 662 DSDIALIQLSSPLEYNSVVRPVCLPHSAEPLFSSEI 697
Score = 57.8 bits (138), Expect = 1e-08
Identities = 39/117 (33%), Positives = 58/117 (49%), Gaps = 5/117 (4%)
Query: 213 YSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLP--KSWTI 270
+ SRI S ++ PWQ SL+ +H CGGS+I ++TAAHC+ L K+ T+
Sbjct: 43 FFSRISSWRNSTVTGHPWQVSLKSDEHHFCGGSLIQEDRVVTAAHCLDSLSEKQLKNITV 102
Query: 271 QVGLVSLL--DNPAPSHLVEKIVYHSKYKPKR-LGNDIALMKLAGPLTFNGTSGSLC 324
G SL D + V KI+ H +Y + + DIAL+ L + F +C
Sbjct: 103 TSGEYSLFQKDKQEQNIPVSKIITHPEYNSREYMSPDIALLYLKHKVKFGNAVQPIC 159
>gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo
sapiens]
Length = 421
Score = 88.2 bits (217), Expect = 1e-17
Identities = 91/318 (28%), Positives = 148/318 (46%), Gaps = 38/318 (11%)
Query: 46 LKFFPIIVIGIIAL-ILALAIGLGIHF---DCSGKYRCRSSFKCIE-LIARCDGVSDCKD 100
LK + I V+ +++L ++A+ IGL +HF D +Y SFK ++ I G S+
Sbjct: 15 LKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYY-HGSFKILDPQINNNFGQSNTYQ 73
Query: 101 GEDEYRCVRVGGQNAVLQV---FTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLR 157
+D +R +N V QV F ++WK K + N V D +
Sbjct: 74 LKD----LRETTENLVSQVDEIFIDSAWK-------KNYIKNQVVRLTPEEDGVKVDVIM 122
Query: 158 V----SSLEGQFREEFVSIDHLLPDDKVTALH------HSVYVREGCASGHVVTLQCTAC 207
V S+ + RE+ I +L + K+ L SV V +S +T+Q + C
Sbjct: 123 VFQFPSTEQRAVREK--KIQSIL-NQKIRNLRALPINASSVQVNAMSSSTGELTVQAS-C 178
Query: 208 GHRRG--YSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLP 265
G R +RI G ++ + WPWQASLQ+ H CG ++I+ W++TAAHC P
Sbjct: 179 GKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNP 238
Query: 266 KSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGSLCG 325
WT+ G + ++ P V + + H KY+ DIA+++++ +TF+ +C
Sbjct: 239 HQWTVSFG--TKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICL 296
Query: 326 SAALPLFQEDLQLLIEAF 343
A FQ +L + I F
Sbjct: 297 PEASASFQPNLTVHITGF 314
>gi|117956391 protease, serine, 33 [Homo sapiens]
Length = 280
Score = 86.3 bits (212), Expect = 4e-17
Identities = 46/122 (37%), Positives = 69/122 (56%), Gaps = 5/122 (4%)
Query: 206 ACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLP 265
ACG R SSRIVGG +WPWQAS+Q +G H+CGGS+I P W++TAAHC LP
Sbjct: 27 ACGQPR-MSSRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPRRALP 85
Query: 266 KSWTIQVGLVSLLDNPAPSHL---VEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGS 322
+ +++G + L + +P L V +++ Y D+AL++L P+ +
Sbjct: 86 AEYRVRLGALR-LGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSARVQP 144
Query: 323 LC 324
+C
Sbjct: 145 VC 146
>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
Length = 423
Score = 85.9 bits (211), Expect = 5e-17
Identities = 50/144 (34%), Positives = 70/144 (48%), Gaps = 12/144 (8%)
Query: 207 CGHRR----GYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDL 262
CG RR G S RIVGG +WPWQASLQ+ G H CG ++I W+++AAHC
Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237
Query: 263 YLPKSWTIQVGLVSLLDNPAPSHL---VEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGT 319
P WT G+ PS + + +I+ H KYK DI+L +L+ P+ +
Sbjct: 238 KNPARWTASFGVTI-----KPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNA 292
Query: 320 SGSLCGSAALPLFQEDLQLLIEAF 343
+C A FQ + + F
Sbjct: 293 VHRVCLPDASYEFQPGDVMFVTGF 316
>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
Length = 423
Score = 85.9 bits (211), Expect = 5e-17
Identities = 50/144 (34%), Positives = 70/144 (48%), Gaps = 12/144 (8%)
Query: 207 CGHRR----GYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDL 262
CG RR G S RIVGG +WPWQASLQ+ G H CG ++I W+++AAHC
Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237
Query: 263 YLPKSWTIQVGLVSLLDNPAPSHL---VEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGT 319
P WT G+ PS + + +I+ H KYK DI+L +L+ P+ +
Sbjct: 238 KNPARWTASFGVTI-----KPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNA 292
Query: 320 SGSLCGSAALPLFQEDLQLLIEAF 343
+C A FQ + + F
Sbjct: 293 VHRVCLPDASYEFQPGDVMFVTGF 316
>gi|4506153 prostasin preproprotein [Homo sapiens]
Length = 343
Score = 84.7 bits (208), Expect = 1e-16
Identities = 40/128 (31%), Positives = 72/128 (56%), Gaps = 2/128 (1%)
Query: 215 SRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGL 274
+RI GG+ ++ QWPWQ S+ ++G H+CGGS+++ W+++AAHC + +++ +++G
Sbjct: 43 ARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGA 102
Query: 275 VSL--LDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGSLCGSAALPLF 332
L A ++ I+ H Y + DIAL++L+ P+TF+ +C AA F
Sbjct: 103 HQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASF 162
Query: 333 QEDLQLLI 340
L +
Sbjct: 163 PNGLHCTV 170
>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
Length = 418
Score = 84.3 bits (207), Expect = 1e-16
Identities = 79/293 (26%), Positives = 127/293 (43%), Gaps = 33/293 (11%)
Query: 51 IIVIGIIALILALAIGLGIHFDCSGK--YRCRSSFKCIELIARCDGVSDCKDGEDEYRCV 108
I+V G++ ILA+ I L ++F + Y RSSF+ + + S EYR +
Sbjct: 22 IVVAGVV--ILAVTIALLVYFLAFDQKSYFYRSSFQLLNVEYNSQLNSPATQ---EYRTL 76
Query: 109 RVGGQNAVLQVFTAASWKTM--------CSDDWKGHYANVACA-QLGFPSYVSSDNLRVS 159
++ + + F ++ + D G A+V Q + +S R+
Sbjct: 77 SGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKFQFTRNNNGASMKSRIE 136
Query: 160 SLEGQFREEFVSIDHLLPDDKVTALHHSV----YVREGCASGHVVTLQCTACGHRRGYSS 215
S+ Q +++ + P ++T+L + E A ++TL
Sbjct: 137 SVLRQMLNNSGNLE-INPSTEITSLTDQAAANWLINECGAGPDLITLS----------EQ 185
Query: 216 RIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLV 275
RI+GG + WPWQ SL+ H CGGS+I +WI+TAAHC P+ W G+
Sbjct: 186 RILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGIS 245
Query: 276 SLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGSLCGSAA 328
+ P V I+ H+ YK NDIAL++L +TF S+C AA
Sbjct: 246 TTF--PKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAA 296
>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
Length = 717
Score = 82.8 bits (203), Expect = 4e-16
Identities = 72/243 (29%), Positives = 98/243 (40%), Gaps = 34/243 (13%)
Query: 75 GKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSD--D 132
G +RC S C+ RCDGV+DC D DE CV Q A +C D
Sbjct: 361 GSFRCSSGL-CVPQAQRCDGVNDCFDESDELFCV--SPQPACNTSSFRQHGPLICDGFRD 417
Query: 133 WKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLL--PDDKVTALHHSVYV 190
+ C Q S ++ + FR++ D + PD
Sbjct: 418 CENGRDEQNCTQ----SIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSD--------- 464
Query: 191 REGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPL 250
EGC C RI+GG +L WPWQ SL F G CG SVI+
Sbjct: 465 EEGCT-----------CSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISRE 513
Query: 251 WIITAAHCVYDLYL--PKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALM 308
W+++AAHC + L P WT +G+ + N V +IV H Y + DIAL+
Sbjct: 514 WLLSAAHCFHGNRLSDPTPWTAHLGMY-VQGNAKFVSPVRRIVVHEYYNSQTFDYDIALL 572
Query: 309 KLA 311
+L+
Sbjct: 573 QLS 575
Score = 32.0 bits (71), Expect = 0.83
Identities = 17/43 (39%), Positives = 22/43 (51%), Gaps = 7/43 (16%)
Query: 72 DCSGKYRCRS-SFKCIELI------ARCDGVSDCKDGEDEYRC 107
+C+ C + +FKC I A+CDG DC DG DE C
Sbjct: 426 NCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGC 468
>gi|4503627 coagulation factor XI precursor [Homo sapiens]
Length = 625
Score = 82.4 bits (202), Expect = 5e-16
Identities = 43/114 (37%), Positives = 62/114 (54%), Gaps = 5/114 (4%)
Query: 216 RIVGGNMSLLSQWPWQASLQFQG---YHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQV 272
RIVGG S+ +WPWQ +L HLCGGS+I WI+TAAHC Y + PK +
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYS 446
Query: 273 GLV--SLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGSLC 324
G++ S + V++I+ H +YK G DIAL+KL + + + +C
Sbjct: 447 GILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPIC 500
>gi|21614531 testisin isoform 2 [Homo sapiens]
Length = 312
Score = 82.4 bits (202), Expect = 5e-16
Identities = 48/128 (37%), Positives = 72/128 (56%), Gaps = 7/128 (5%)
Query: 207 CGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCV-YDLYLP 265
CG RR +SRIVGG + L +WPWQ SL+ H+CG S+++ W +TAAHC DL P
Sbjct: 33 CG-RRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDP 91
Query: 266 KSWTIQVGLVSLLDN--PAPSHLVEKIVYHSKYKPKRLGN---DIALMKLAGPLTFNGTS 320
W +Q G ++ + + ++ V + P+ LGN DIAL+KL+ P+T+
Sbjct: 92 SGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHI 151
Query: 321 GSLCGSAA 328
+C A+
Sbjct: 152 QPICLQAS 159
>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
Length = 811
Score = 82.0 bits (201), Expect = 7e-16
Identities = 49/138 (35%), Positives = 74/138 (53%), Gaps = 5/138 (3%)
Query: 207 CGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPK 266
CG +G SSRIVGG +S +WPWQASLQ +G H+CGG++I W+ITAAHC + +
Sbjct: 568 CG-LQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMAS 626
Query: 267 S--WTIQVGLVSLLDN--PAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGS 322
+ WT+ +G V S V +++ H ++ D+AL++L P+ +
Sbjct: 627 TVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRP 686
Query: 323 LCGSAALPLFQEDLQLLI 340
+C A F+ L I
Sbjct: 687 VCLPARSHFFEPGLHCWI 704
Score = 37.7 bits (86), Expect = 0.015
Identities = 14/35 (40%), Positives = 19/35 (54%)
Query: 73 CSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
C ++C+ CI L CDG DC +G DE +C
Sbjct: 491 CRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQC 525
Score = 36.2 bits (82), Expect = 0.044
Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 10/64 (15%)
Query: 52 IVIGIIALILALAIGLGIHFD-------CSGKYRCRSSFKCIELIARCDGVSDCKDGEDE 104
I I + I G+ +H+ C G++ C + C+ CDGV DC +G DE
Sbjct: 430 ITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVNGLCVPA---CDGVKDCPNGLDE 486
Query: 105 YRCV 108
CV
Sbjct: 487 RNCV 490
Score = 29.6 bits (65), Expect = 4.1
Identities = 10/17 (58%), Positives = 12/17 (70%)
Query: 91 RCDGVSDCKDGEDEYRC 107
+CDG DC+DG DE C
Sbjct: 550 QCDGRPDCRDGSDEEHC 566
>gi|58218970 protease, serine, 36 [Homo sapiens]
Length = 855
Score = 82.0 bits (201), Expect = 7e-16
Identities = 48/124 (38%), Positives = 67/124 (54%), Gaps = 8/124 (6%)
Query: 207 CGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVY---DLY 263
CG R S+RIVGG+ + WPWQ SL G H+CGGS+I P W+++AAHC L
Sbjct: 38 CG-RPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLE 96
Query: 264 LPKSWTIQVGLVSLLDNP---APSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTS 320
W++ +G+ S D P A + V IV + Y LG D+AL++LA P +
Sbjct: 97 PAAEWSVLLGVHS-QDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAV 155
Query: 321 GSLC 324
+C
Sbjct: 156 WPVC 159
Score = 42.0 bits (97), Expect = 8e-04
Identities = 25/104 (24%), Positives = 45/104 (43%), Gaps = 14/104 (13%)
Query: 228 WPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKS-------WTIQVGLVSLLDN 280
WPW+A + G C G++++ W++ A C D S W + LL +
Sbjct: 334 WPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRV------LLPS 387
Query: 281 PAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGSLC 324
+ V ++V H +D+AL++L P+ + S +C
Sbjct: 388 RPRAERVARLVQHENASWDN-ASDLALLQLRTPVNLSAASRPVC 430
Score = 40.4 bits (93), Expect = 0.002
Identities = 30/103 (29%), Positives = 50/103 (48%), Gaps = 10/103 (9%)
Query: 228 WPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPS--- 284
WPW A + G +C G ++ P W++ A HCV P S T+ V L A S
Sbjct: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCV---LRPGSTTVPYIEVYLGRAGASSLPQ 657
Query: 285 -HLVEKIVYHSKYKPKRLG--NDIALMKLAGPLTFNGTSGSLC 324
H V ++V + P+ LG +AL++L+ + + ++ +C
Sbjct: 658 GHQVSRLVISIRL-PQHLGLRPPLALLELSSRVEPSPSALPIC 699
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.441
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,716,341
Number of Sequences: 37866
Number of extensions: 610468
Number of successful extensions: 2033
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 195
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 1345
Number of HSP's gapped (non-prelim): 574
length of query: 344
length of database: 18,247,518
effective HSP length: 103
effective length of query: 241
effective length of database: 14,347,320
effective search space: 3457704120
effective search space used: 3457704120
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.