Search of human proteins with 145701030

Search of human proteins with 145701030

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
sapiens]
         (432 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   899   0.0  
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   893   0.0  
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         261   9e-70
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   252   4e-67
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   252   4e-67
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   239   4e-63
gi|33695155 hepsin [Homo sapiens]                                     221   8e-58
gi|4504481 hepsin [Homo sapiens]                                      221   8e-58
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          220   2e-57
gi|223942069 enterokinase precursor [Homo sapiens]                    211   1e-54
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          209   3e-54
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           194   2e-49
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             188   7e-48
gi|187761337 transmembrane protease, serine 11B [Homo sapiens]        187   2e-47
gi|194018492 transmembrane protease, serine 11F [Homo sapiens]        186   3e-47
gi|148613878 acrosin precursor [Homo sapiens]                         185   8e-47
gi|40254871 transmembrane protease, serine 11E [Homo sapiens]         184   2e-46
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]       184   2e-46
gi|117956391 protease, serine, 33 [Homo sapiens]                      183   3e-46
gi|205360905 testis-specific serine protease 1 [Homo sapiens]         182   4e-46
gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]      182   4e-46
gi|5803197 testisin isoform 1 [Homo sapiens]                          182   7e-46
gi|21614531 testisin isoform 2 [Homo sapiens]                         180   3e-45
gi|13994276 marapsin [Homo sapiens]                                   179   4e-45
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           178   7e-45
gi|11545839 protease, serine, 22 [Homo sapiens]                       178   7e-45
gi|29244926 corin [Homo sapiens]                                      174   1e-43
gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ...   174   2e-43
gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo ...   174   2e-43
gi|4506153 prostasin preproprotein [Homo sapiens]                     171   9e-43

>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
           sapiens]
          Length = 432

 Score =  899 bits (2324), Expect = 0.0
 Identities = 432/432 (100%), Positives = 432/432 (100%)

Query: 1   MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKY 60
           MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKY
Sbjct: 1   MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKY 60

Query: 61  YFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSAT 120
           YFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSAT
Sbjct: 61  YFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSAT 120

Query: 121 GNWFSACFDNFTEALAETACRQMGYSRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLS 180
           GNWFSACFDNFTEALAETACRQMGYSRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLS
Sbjct: 121 GNWFSACFDNFTEALAETACRQMGYSRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLS 180

Query: 181 GSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAH 240
           GSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAH
Sbjct: 181 GSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAH 240

Query: 241 CFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGT 300
           CFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGT
Sbjct: 241 CFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGT 300

Query: 301 VRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGE 360
           VRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGE
Sbjct: 301 VRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGE 360

Query: 361 VTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAY 420
           VTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAY
Sbjct: 361 VTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAY 420

Query: 421 LNWIYNVWKAEL 432
           LNWIYNVWKAEL
Sbjct: 421 LNWIYNVWKAEL 432


>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
           sapiens]
          Length = 437

 Score =  893 bits (2308), Expect = 0.0
 Identities = 432/437 (98%), Positives = 432/437 (98%), Gaps = 5/437 (1%)

Query: 1   MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKY 60
           MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKY
Sbjct: 1   MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKY 60

Query: 61  YFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSAT 120
           YFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSAT
Sbjct: 61  YFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSAT 120

Query: 121 GNWFSACFDNFTEALAETACRQMGYS-----RAVEIGPDQDLDVVEITENSQELRMRNSS 175
           GNWFSACFDNFTEALAETACRQMGYS     RAVEIGPDQDLDVVEITENSQELRMRNSS
Sbjct: 121 GNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSS 180

Query: 176 GPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWV 235
           GPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWV
Sbjct: 181 GPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWV 240

Query: 236 LTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPL 295
           LTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPL
Sbjct: 241 LTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPL 300

Query: 296 TFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADD 355
           TFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADD
Sbjct: 301 TFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADD 360

Query: 356 AYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYT 415
           AYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYT
Sbjct: 361 AYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYT 420

Query: 416 KVSAYLNWIYNVWKAEL 432
           KVSAYLNWIYNVWKAEL
Sbjct: 421 KVSAYLNWIYNVWKAEL 437


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  261 bits (667), Expect = 9e-70
 Identities = 145/408 (35%), Positives = 214/408 (52%), Gaps = 20/408 (4%)

Query: 34  IPII-IALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQL-CDGELDCPLGEDEEH 91
           +P+I   LL +A ++ +++L +           +     P+  + CDG +DC L  DE  
Sbjct: 166 LPLIGCVLLLIALVVSLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELG 225

Query: 92  CVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYS---RA 148
           CV           R   D+S L++   ++  W   C  N+ ++ +E  C+Q+G+    R 
Sbjct: 226 CV-----------RFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRT 274

Query: 149 VEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGGEEASV 208
            E+      +   I   +  ++       C S   +SL C  CG    T R+VGG  AS 
Sbjct: 275 TEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAMTGRIVGGALASD 334

Query: 209 DSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCF--RKHTDVFNWKVRAGSDKLGSFPSL 266
             WPWQVS+ +   H+CGG+++D  WVLTAAHCF   +   +  WKV AG+  L   P  
Sbjct: 335 SKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEA 394

Query: 267 AVAKIIIIEFNPMYPKDN-DIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWG 325
           A    III  N    +D+ DIALM+L  PLT S  + P CLP   +  +     WI G+G
Sbjct: 395 ASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFG 454

Query: 326 FTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGP 385
            T++   K S  L +  V +ID  +CN    Y   +T +MMCAG   GG D+CQGDSGGP
Sbjct: 455 KTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGP 514

Query: 386 LM-YQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL 432
           L+  Q+++W++ G+ SWG GCG  + PGVYTKV+  L WIY+  ++E+
Sbjct: 515 LVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEV 562


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  252 bits (644), Expect = 4e-67
 Identities = 144/375 (38%), Positives = 201/375 (53%), Gaps = 36/375 (9%)

Query: 77  CDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALA 136
           CDG   CP GEDE  CV+ +  GP            LQV  S   +W   C D++ E   
Sbjct: 170 CDGVSHCPGGEDENRCVRLY--GP---------NFILQVYSSQRKSWHPVCQDDWNENYG 218

Query: 137 ETACRQMGYSRAVEIGPDQDLDVVEITENSQELRMRNSSG------------PCLSGSLV 184
             ACR MGY             +V+ + ++  +++  S+G             C S ++V
Sbjct: 219 RAACRDMGYKNNFY----SSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVV 274

Query: 185 SLHCLACGKSLKTPR---VVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHC 241
           SL C+ACG +L + R   +VGGE A   +WPWQVS+     HVCGGSI+ P W++TAAHC
Sbjct: 275 SLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHC 334

Query: 242 FRKH-TDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMY---PKDNDIALMKLQFPLTF 297
             K   + ++W   AG  +       A  ++  +  +P Y    K+NDIALMKLQ PLTF
Sbjct: 335 VEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTF 394

Query: 298 SGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAY 357
           +  V+P+CLP     L P    WI GWG T++  GK S++L  A V +I++ RCN+   Y
Sbjct: 395 NDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK-GKTSEVLNAAKVLLIETQRCNSRYVY 453

Query: 358 QGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQ-WHVVGIVSWGYGCGGPSTPGVYTK 416
              +T  M+CAG  +G VD+CQGDSGGPL+   +  W ++G  SWG GC     PGVY  
Sbjct: 454 DNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGN 513

Query: 417 VSAYLNWIYNVWKAE 431
           V  + +WIY   +A+
Sbjct: 514 VMVFTDWIYRQMRAD 528


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  252 bits (644), Expect = 4e-67
 Identities = 144/375 (38%), Positives = 201/375 (53%), Gaps = 36/375 (9%)

Query: 77  CDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALA 136
           CDG   CP GEDE  CV+ +  GP            LQV  S   +W   C D++ E   
Sbjct: 133 CDGVSHCPGGEDENRCVRLY--GP---------NFILQVYSSQRKSWHPVCQDDWNENYG 181

Query: 137 ETACRQMGYSRAVEIGPDQDLDVVEITENSQELRMRNSSG------------PCLSGSLV 184
             ACR MGY             +V+ + ++  +++  S+G             C S ++V
Sbjct: 182 RAACRDMGYKNNFY----SSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVV 237

Query: 185 SLHCLACGKSLKTPR---VVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHC 241
           SL C+ACG +L + R   +VGGE A   +WPWQVS+     HVCGGSI+ P W++TAAHC
Sbjct: 238 SLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHC 297

Query: 242 FRKH-TDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMY---PKDNDIALMKLQFPLTF 297
             K   + ++W   AG  +       A  ++  +  +P Y    K+NDIALMKLQ PLTF
Sbjct: 298 VEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTF 357

Query: 298 SGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAY 357
           +  V+P+CLP     L P    WI GWG T++  GK S++L  A V +I++ RCN+   Y
Sbjct: 358 NDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK-GKTSEVLNAAKVLLIETQRCNSRYVY 416

Query: 358 QGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQ-WHVVGIVSWGYGCGGPSTPGVYTK 416
              +T  M+CAG  +G VD+CQGDSGGPL+   +  W ++G  SWG GC     PGVY  
Sbjct: 417 DNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGN 476

Query: 417 VSAYLNWIYNVWKAE 431
           V  + +WIY   +A+
Sbjct: 477 VMVFTDWIYRQMRAD 491


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  239 bits (610), Expect = 4e-63
 Identities = 147/431 (34%), Positives = 216/431 (50%), Gaps = 44/431 (10%)

Query: 24  IPMETFRKVGIPIIIALLSLASIIIVVVLIKVILD-KYYFLCGQPLHFIPRKQLCDGELD 82
           +P++ F  + I II  +L+LA      + + +  D    + C      I     CDG  D
Sbjct: 44  LPLKFFPIIVIGIIALILALA------IGLGIHFDCSGKYRCRSSFKCIELIARCDGVSD 97

Query: 83  CPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQ 142
           C  GEDE  CV           R+    + LQV  +A+  W + C D++    A  AC Q
Sbjct: 98  CKDGEDEYRCV-----------RVGGQNAVLQVFTAAS--WKTMCSDDWKGHYANVACAQ 144

Query: 143 MGYSRAVE-----------------IGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVS 185
           +G+   V                  +  D  L   ++T     + +R     C SG +V+
Sbjct: 145 LGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREG---CASGHVVT 201

Query: 186 LHCLACG-KSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRK 244
           L C ACG +   + R+VGG  + +  WPWQ S+Q+   H+CGGS++ P W++TAAHC   
Sbjct: 202 LQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYD 261

Query: 245 HTDVFNWKVRAGSDKL--GSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVR 302
                +W ++ G   L     PS  V KI+           NDIALMKL  PLTF+  ++
Sbjct: 262 LYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQ 321

Query: 303 PICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVT 362
           P+CLP  +E        W  GWG T+   G  S +L  A+V +I +  CN  D Y G ++
Sbjct: 322 PVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIIS 381

Query: 363 EKMMCAGIPEGGVDTCQGDSGGPLMYQSDQ-WHVVGIVSWGYGCGGPSTPGVYTKVSAYL 421
             M+CAG   GGVD+CQGDSGGPL+ Q  + W +VG  S+G GC   + PGVYT+V+++L
Sbjct: 382 PSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFL 441

Query: 422 NWIYNVWKAEL 432
           +WI+   + +L
Sbjct: 442 DWIHEQMERDL 452


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  221 bits (564), Expect = 8e-58
 Identities = 129/360 (35%), Positives = 179/360 (49%), Gaps = 34/360 (9%)

Query: 100 PAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSRAVEIGPDQDLDV 159
           P   V++S   + L V D   G W   C       +A  +C +MG+ RA+      +LDV
Sbjct: 50  PLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALT---HSELDV 106

Query: 160 VEITEN---------------SQELRMRNSSGPCLSGSLVSLHCLACGK-SLKTPRVVGG 203
                N               +Q L    S   C  G  ++  C  CG+  L   R+VGG
Sbjct: 107 RTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGG 166

Query: 204 EEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFN-WKVRAGSDKLGS 262
            + S+  WPWQVS++YD  H+CGGS+L   WVLTAAHCF +   V + W+V AG+    S
Sbjct: 167 RDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQAS 226

Query: 263 FPSLAVAKIIIIEFNPMYP--------KDNDIALMKLQFPLTFSGTVRPICLPFFDEELT 314
              L +    ++      P          NDIAL+ L  PL  +  ++P+CLP   + L 
Sbjct: 227 PHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALV 286

Query: 315 PATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGG 374
                 + GWG T Q  G+ + +L +A V +I +  CN  D Y  ++  KM CAG PEGG
Sbjct: 287 DGKICTVTGWGNT-QYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGG 345

Query: 375 VDTCQGDSGGPLMYQ-----SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWK 429
           +D CQGDSGGP + +     + +W + GIVSWG GC     PGVYTKVS +  WI+   K
Sbjct: 346 IDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  221 bits (564), Expect = 8e-58
 Identities = 129/360 (35%), Positives = 179/360 (49%), Gaps = 34/360 (9%)

Query: 100 PAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSRAVEIGPDQDLDV 159
           P   V++S   + L V D   G W   C       +A  +C +MG+ RA+      +LDV
Sbjct: 50  PLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALT---HSELDV 106

Query: 160 VEITEN---------------SQELRMRNSSGPCLSGSLVSLHCLACGK-SLKTPRVVGG 203
                N               +Q L    S   C  G  ++  C  CG+  L   R+VGG
Sbjct: 107 RTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGG 166

Query: 204 EEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFN-WKVRAGSDKLGS 262
            + S+  WPWQVS++YD  H+CGGS+L   WVLTAAHCF +   V + W+V AG+    S
Sbjct: 167 RDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQAS 226

Query: 263 FPSLAVAKIIIIEFNPMYP--------KDNDIALMKLQFPLTFSGTVRPICLPFFDEELT 314
              L +    ++      P          NDIAL+ L  PL  +  ++P+CLP   + L 
Sbjct: 227 PHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALV 286

Query: 315 PATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGG 374
                 + GWG T Q  G+ + +L +A V +I +  CN  D Y  ++  KM CAG PEGG
Sbjct: 287 DGKICTVTGWGNT-QYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGG 345

Query: 375 VDTCQGDSGGPLMYQ-----SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWK 429
           +D CQGDSGGP + +     + +W + GIVSWG GC     PGVYTKVS +  WI+   K
Sbjct: 346 IDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  220 bits (560), Expect = 2e-57
 Identities = 122/365 (33%), Positives = 183/365 (50%), Gaps = 24/365 (6%)

Query: 81  LDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETAC 140
           L C     EE  + + P+   V+ R++ +   L+        W   C + ++ AL    C
Sbjct: 91  LSCSEASAEEALLPALPK--TVSFRINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQIC 148

Query: 141 RQMGYSRAVEIGPDQDLDVVEITENSQELRMRNSS-------------GPCLSGSLVSLH 187
             +G+ R       + +++ +I  NS +   + S                C SG +VSL 
Sbjct: 149 WSLGHLRLTH---HKGVNLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLR 205

Query: 188 CLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKH-- 245
           C  CG      R+VGG+  +   WPWQ S+    +H CGGS+L P WV+TAAHC      
Sbjct: 206 CSECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRL 265

Query: 246 TDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDN---DIALMKLQFPLTFSGTVR 302
             + +W+V AG     +      A +  I  +P+Y   N   D+AL++LQ  L FS TV 
Sbjct: 266 ARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVG 325

Query: 303 PICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVT 362
            +CLP  ++     +  W+ GWG T  +    SD+L    V +  +  CN+   Y G +T
Sbjct: 326 AVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALT 385

Query: 363 EKMMCAGIPEGGVDTCQGDSGGPLMY-QSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYL 421
            +M+CAG  +G  D CQGDSGGPL+    D W +VG+VSWG GC  P+ PGVY KV+ +L
Sbjct: 386 PRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFL 445

Query: 422 NWIYN 426
           +WI++
Sbjct: 446 DWIHD 450


>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score =  211 bits (537), Expect = 1e-54
 Identities = 128/370 (34%), Positives = 191/370 (51%), Gaps = 27/370 (7%)

Query: 71   IPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDN 130
            +P   LCDG L C  G DE  CV+ F  G      L + R  +Q +      W +AC +N
Sbjct: 656  VPLVNLCDGHLHCEDGSDEADCVRFF-NGTTNNNGLVRFR--IQSI------WHTACAEN 706

Query: 131  FTEALAETACRQMGYSRAVEIGPDQDLD---VVEITENSQELRMRNSSGPCLSGSLVSLH 187
            +T  ++   C+ +G        P    D    V++        +   S  CL  SL+ L 
Sbjct: 707  WTTQISNDVCQLLGLGSGNSSKPIFSTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQ 766

Query: 188  C--LACGKSLK----TPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHC 241
            C   +CGK L     TP++VGG  A   +WPW V + Y  + +CG S++   W+++AAHC
Sbjct: 767  CNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHC 826

Query: 242  -FRKHTDVFNWKVRAGSDKLGSFPSLAVAKIII--IEFNPMY---PKDNDIALMKLQFPL 295
             + ++ +   W    G     +  S      +I  I  NP Y    KDNDIA+M L+F +
Sbjct: 827  VYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKV 886

Query: 296  TFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADD 355
             ++  ++PICLP  ++   P     I GWG T    G  ++IL +A V ++ + RC    
Sbjct: 887  NYTDYIQPICLPEENQVFPPGRNCSIAGWG-TVVYQGTTANILQEADVPLLSNERCQ-QQ 944

Query: 356  AYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQ-SDQWHVVGIVSWGYGCGGPSTPGVY 414
              +  +TE M+CAG  EGG+D+CQGDSGGPLM Q +++W + G+ S+GY C  P+ PGVY
Sbjct: 945  MPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVY 1004

Query: 415  TKVSAYLNWI 424
             +VS +  WI
Sbjct: 1005 ARVSRFTEWI 1014



 Score = 29.6 bits (65), Expect = 5.6
 Identities = 12/28 (42%), Positives = 16/28 (57%)

Query: 64  CGQPLHFIPRKQLCDGELDCPLGEDEEH 91
           C   L  I     CDGE++CP G DE++
Sbjct: 191 CTDALTCIKADLFCDGEVNCPDGSDEDN 218


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  209 bits (533), Expect = 3e-54
 Identities = 136/417 (32%), Positives = 214/417 (51%), Gaps = 47/417 (11%)

Query: 35  PIIIALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRK--QLCDGELDCPL------- 85
           P ++  + +A ++I+ V I +++   YFL      +  R   QL + E +  L       
Sbjct: 16  PYVVCFIVVAGVVILAVTIALLV---YFLAFDQKSYFYRSSFQLLNVEYNSQLNSPATQE 72

Query: 86  -----GEDEEHCVKSFPEGP-------AVAVRLSKDRSTLQVLDSATGNWFSACFDNFT- 132
                G  E    K+F E         A   +L +D S ++  D      F+   +  + 
Sbjct: 73  YRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRA-DVVMKFQFTRNNNGASM 131

Query: 133 EALAETACRQM-GYSRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLAC 191
           ++  E+  RQM   S  +EI P  ++  +     +  L     +GP L            
Sbjct: 132 KSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLI----------- 180

Query: 192 GKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNW 251
             +L   R++GG EA   SWPWQVS++ +  H CGGS+++  W+LTAAHCFR +++  +W
Sbjct: 181 --TLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDW 238

Query: 252 KVRAGSDKLGSFPSL--AVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFF 309
              +G     +FP L   V  I+I         +NDIAL++L+  +TF+  +  +CLP  
Sbjct: 239 IATSGIST--TFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAA 296

Query: 310 DEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAG 369
            + + P +  ++ GWG  +  G  + + L Q  V++I +  CNA  +Y G +   M+CAG
Sbjct: 297 TQNIPPGSTAYVTGWGAQEYAGHTVPE-LRQGQVRIISNDVCNAPHSYNGAILSGMLCAG 355

Query: 370 IPEGGVDTCQGDSGGPLMYQSDQ--WHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 424
           +P+GGVD CQGDSGGPL+ +  +  W +VGIVSWG  CG P  PGVYT+V+AYL+WI
Sbjct: 356 VPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWI 412


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  194 bits (492), Expect = 2e-49
 Identities = 128/378 (33%), Positives = 188/378 (49%), Gaps = 42/378 (11%)

Query: 62  FLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATG 121
           FLC      +P    CDG  DCP G DE +CV                R+T Q  + +T 
Sbjct: 462 FLCSVNGLCVPA---CDGVKDCPNGLDERNCVC---------------RATFQCKEDSTC 503

Query: 122 NWFSACFDNFTEALA---ETACRQMGYSRAVEIGPDQDLDVVEITENSQELRMRNSSGPC 178
                  D   + L    E  C++ G          +D   V+      + R       C
Sbjct: 504 ISLPKVCDGQPDCLNGSDEEQCQE-GVPCGTFTFQCEDRSCVKKPNPQCDGRP-----DC 557

Query: 179 LSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTA 238
             GS    HC  CG    + R+VGG  +S   WPWQ S+Q   +H+CGG+++   WV+TA
Sbjct: 558 RDGSDEE-HC-DCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITA 615

Query: 239 AHCFRKHT-------DVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKL 291
           AHCF++ +        VF  KV   S   G   S  V+++++  ++     D D+AL++L
Sbjct: 616 AHCFQEDSMASTVLWTVFLGKVWQNSRWPGEV-SFKVSRLLLHPYHEEDSHDYDVALLQL 674

Query: 292 QFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRC 351
             P+  S  VRP+CLP       P    WI GWG  ++ GG +S+ L +  VQ+I    C
Sbjct: 675 DHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALRE-GGPISNALQKVDVQLIPQDLC 733

Query: 352 NADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQ--SDQWHVVGIVSWGYGCGGPS 409
           +  + Y+ +VT +M+CAG  +G  D CQGDSGGPL+ +  S +W + G+VSWG GCG P+
Sbjct: 734 S--EVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPN 791

Query: 410 TPGVYTKVSAYLNWIYNV 427
             GVYT+++  ++WI  V
Sbjct: 792 YFGVYTRITGVISWIQQV 809


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  188 bits (478), Expect = 7e-48
 Identities = 98/235 (41%), Positives = 145/235 (61%), Gaps = 12/235 (5%)

Query: 199 RVVGGEEASVDSWPWQVSIQYD---KQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRA 255
           R+VGG  +S   WPWQVS+Q     ++H+CGGS++   WVLTAAHCF        W++ +
Sbjct: 390 RIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYS 449

Query: 256 G----SDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDE 311
           G    SD     P   + +III +   +   ++DIAL+KLQ PL ++   +PICLP   +
Sbjct: 450 GILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGD 509

Query: 312 ELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQG-EVTEKMMCAGI 370
             T  T  W+ GWGF+K+  G++ +IL + ++ ++ +  C     YQ  ++T++M+CAG 
Sbjct: 510 TSTIYTNCWVTGWGFSKEK-GEIQNILQKVNIPLVTNEEC--QKRYQDYKITQRMVCAGY 566

Query: 371 PEGGVDTCQGDSGGPLMYQ-SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 424
            EGG D C+GDSGGPL+ + +  W +VGI SWG GC     PGVYTKV+ Y++WI
Sbjct: 567 KEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWI 621


>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
          Length = 416

 Score =  187 bits (474), Expect = 2e-47
 Identities = 99/270 (36%), Positives = 152/270 (56%), Gaps = 14/270 (5%)

Query: 157 LDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVS 216
           + ++EI++ + E+   N  G  ++ S+++ +           ++V G+ +   +WPWQ S
Sbjct: 153 IKLMEISKAASEMLTNNCCGRQVANSIITGN-----------KIVNGKSSLEGAWPWQAS 201

Query: 217 IQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEF 276
           +Q+  +H CG S++   W+L+AAHCF K  +  +W V  G      + +  V  II  E 
Sbjct: 202 MQWKGRHYCGASLISSRWLLSAAHCFAKKNNSKDWTVNFGIVVNKPYMTRKVQNIIFHEN 261

Query: 277 NPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSD 336
                  +DIAL++L   ++F+  +R ICLP    +L+    + + GWG    N G    
Sbjct: 262 YSSPGLHDDIALVQLAEEVSFTEYIRKICLPEAKMKLSENDNVVVTGWGTLYMN-GSFPV 320

Query: 337 ILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQ--WH 394
           IL +  +++ID+  CNA  AY G VT+ M+CAG   G  D CQ DSGGPL Y   +  WH
Sbjct: 321 ILQEDFLKIIDNKICNASYAYSGFVTDTMLCAGFMSGEADACQNDSGGPLAYPDSRNIWH 380

Query: 395 VVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 424
           +VGIVSWG GCG  + PGVYT+V++Y NWI
Sbjct: 381 LVGIVSWGDGCGKKNKPGVYTRVTSYRNWI 410


>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
          Length = 438

 Score =  186 bits (473), Expect = 3e-47
 Identities = 98/234 (41%), Positives = 136/234 (58%), Gaps = 4/234 (1%)

Query: 194 SLKTPRVVGGEEASVDS-WPWQVSIQY-DKQHVCGGSILDPHWVLTAAHCFRKHTDVFNW 251
           S  T R+V G E +++  WPWQ S+Q     H CG S++   W+LTAAHCF K+ D   W
Sbjct: 200 SSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQW 259

Query: 252 KVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDE 311
               G+          V KII+ E       +NDIAL++L   + FS  V+ +CLP    
Sbjct: 260 IATFGATITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSI 319

Query: 312 ELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIP 371
           +L P T +++ G+G    +G  + + L QA V+ I +  CN  D Y G +T  M+CAG  
Sbjct: 320 KLPPKTSVFVTGFGSIVDDG-PIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFM 378

Query: 372 EGGVDTCQGDSGGPLMYQS-DQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 424
           EG +D C+GDSGGPL+Y + D W++VGIVSWG  C  P  PGVYT+V+ Y +WI
Sbjct: 379 EGKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWI 432


>gi|148613878 acrosin precursor [Homo sapiens]
          Length = 421

 Score =  185 bits (469), Expect = 8e-47
 Identities = 98/244 (40%), Positives = 135/244 (55%), Gaps = 18/244 (7%)

Query: 199 RVVGGEEASVDSWPWQVSIQY-----DKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKV 253
           R+VGG+ A   +WPW VS+Q       + H CGGS+L+  WVLTAAHCF    +V +W++
Sbjct: 42  RIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRL 101

Query: 254 RAGSDKL---------GSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPI 304
             G+ ++                V KIII E      + NDIAL+++  P++    + P 
Sbjct: 102 VFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPG 161

Query: 305 CLPFFDEELTPATP-LWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTE 363
           CLP F   L   +   W+ GWG+ ++   + S IL++A V +ID   CN+   Y G V  
Sbjct: 162 CLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQP 221

Query: 364 KMMCAGIPEGGVDTCQGDSGGPLMYQSDQ---WHVVGIVSWGYGCGGPSTPGVYTKVSAY 420
             +CAG P G +DTCQGDSGGPLM +  +   + VVGI SWG GC     PG+YT    Y
Sbjct: 222 TNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPY 281

Query: 421 LNWI 424
           LNWI
Sbjct: 282 LNWI 285


>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
          Length = 423

 Score =  184 bits (466), Expect = 2e-46
 Identities = 94/243 (38%), Positives = 135/243 (55%), Gaps = 6/243 (2%)

Query: 187 HCLACGKSL---KTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFR 243
           HC    +S    ++ R+VGG E     WPWQ S+Q+D  H CG ++++  W+++AAHCF 
Sbjct: 176 HCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFT 235

Query: 244 KHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRP 303
            + +   W    G     S     + +II+ E       D DI+L +L  P+ ++  V  
Sbjct: 236 TYKNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHR 295

Query: 304 ICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTE 363
           +CLP    E  P   +++ G+G  K N G   + L QA V +ID+T CN   AY   +T 
Sbjct: 296 VCLPDASYEFQPGDVMFVTGFGALK-NDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITP 354

Query: 364 KMMCAGIPEGGVDTCQGDSGGPLMYQS--DQWHVVGIVSWGYGCGGPSTPGVYTKVSAYL 421
           +M+CAG  EG  D CQGDSGGPL+     D W++ GIVSWG  C  P+ PGVYT+V+A  
Sbjct: 355 RMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALR 414

Query: 422 NWI 424
           +WI
Sbjct: 415 DWI 417


>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
          Length = 423

 Score =  184 bits (466), Expect = 2e-46
 Identities = 94/243 (38%), Positives = 135/243 (55%), Gaps = 6/243 (2%)

Query: 187 HCLACGKSL---KTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFR 243
           HC    +S    ++ R+VGG E     WPWQ S+Q+D  H CG ++++  W+++AAHCF 
Sbjct: 176 HCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFT 235

Query: 244 KHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRP 303
            + +   W    G     S     + +II+ E       D DI+L +L  P+ ++  V  
Sbjct: 236 TYKNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHR 295

Query: 304 ICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTE 363
           +CLP    E  P   +++ G+G  K N G   + L QA V +ID+T CN   AY   +T 
Sbjct: 296 VCLPDASYEFQPGDVMFVTGFGALK-NDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITP 354

Query: 364 KMMCAGIPEGGVDTCQGDSGGPLMYQS--DQWHVVGIVSWGYGCGGPSTPGVYTKVSAYL 421
           +M+CAG  EG  D CQGDSGGPL+     D W++ GIVSWG  C  P+ PGVYT+V+A  
Sbjct: 355 RMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALR 414

Query: 422 NWI 424
           +WI
Sbjct: 415 DWI 417


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  183 bits (464), Expect = 3e-46
 Identities = 103/248 (41%), Positives = 136/248 (54%), Gaps = 13/248 (5%)

Query: 190 ACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVF 249
           ACG+   + R+VGG +     WPWQ SIQ+   HVCGGS++ P WVLTAAHCF +     
Sbjct: 27  ACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPRRALPA 86

Query: 250 NWKVRAGSDKLGS-FPSLAVAKIIIIEFNPMYPKD---NDIALMKLQFPLTFSGTVRPIC 305
            ++VR G+ +LGS  P      +  +   P Y +D    D+AL++L+ P+  S  V+P+C
Sbjct: 87  EYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSARVQPVC 146

Query: 306 LPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQ-ASVQVIDSTRCN-----ADDAYQG 359
           LP       P TP  + GWG  +          LQ   V ++DS  C+       D  Q 
Sbjct: 147 LPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGADVPQA 206

Query: 360 E--VTEKMMCAGIPEGGVDTCQGDSGGPL-MYQSDQWHVVGIVSWGYGCGGPSTPGVYTK 416
           E  V    +CAG P+G  D CQGDSGGPL   QS  W +VG+VSWG GC  P+ PGVYT 
Sbjct: 207 ERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRPGVYTS 266

Query: 417 VSAYLNWI 424
           V+ Y  WI
Sbjct: 267 VATYSPWI 274


>gi|205360905 testis-specific serine protease 1 [Homo sapiens]
          Length = 318

 Score =  182 bits (463), Expect = 4e-46
 Identities = 95/251 (37%), Positives = 138/251 (54%), Gaps = 13/251 (5%)

Query: 190 ACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVF 249
           ACG       V GG E++   WPWQ S++  ++H CGGS+L   WVL+AAHCF+KH    
Sbjct: 45  ACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPS 104

Query: 250 NWKVRAGS-------DKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVR 302
            W V+ G          L ++ S    + II+  + +    NDIAL++L   +T++  ++
Sbjct: 105 EWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQ 164

Query: 303 PICLPFFDEELTPATPLWIIGWGFTKQNGGKMSD--ILLQASVQVIDSTRCN---ADDAY 357
           PIC+             W+ GWG    +G  +     L +A V ++++TRCN      + 
Sbjct: 165 PICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSS 224

Query: 358 QGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD-QWHVVGIVSWGYGCGGPSTPGVYTK 416
           +  + + M CAG  +G VDTC+GDSGGPL+   D  W+ VGIVSWG  CG P+ PGVYT 
Sbjct: 225 RSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTN 284

Query: 417 VSAYLNWIYNV 427
           +S Y +WI  V
Sbjct: 285 ISVYFHWIRRV 295


>gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]
          Length = 321

 Score =  182 bits (463), Expect = 4e-46
 Identities = 95/234 (40%), Positives = 132/234 (56%), Gaps = 13/234 (5%)

Query: 199 RVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSD 258
           R+VGG  A   +WPWQ S++  + HVCGGS+L P WVLTAAHCF    +  +++V  G  
Sbjct: 37  RIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGEL 96

Query: 259 KLGSFPSLAVAKIIIIEFNP--MYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPA 316
           ++   P  +  + II+  +P        DIAL++L  P+T S  + P+CLP   ++  P 
Sbjct: 97  EITLSPHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPG 156

Query: 317 TPLWIIGWGFTKQNGGKMSDI-LLQASVQVIDSTRCNADDAYQGE----VTEKMMCAGIP 371
              W+ GWG+T++         L +  V V+D+  C  D  Y G     +   M+CA   
Sbjct: 157 IRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRD--YPGPGGSILQPDMLCA--- 211

Query: 372 EGGVDTCQGDSGGPLMYQ-SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 424
            G  D CQ DSGGPL+ Q +  W   GIVSWG GCG P+ PGVYT+V AY+NWI
Sbjct: 212 RGPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWI 265


>gi|5803197 testisin isoform 1 [Homo sapiens]
          Length = 314

 Score =  182 bits (461), Expect = 7e-46
 Identities = 98/251 (39%), Positives = 146/251 (58%), Gaps = 19/251 (7%)

Query: 191 CGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFN 250
           CG+ + T R+VGGE+A +  WPWQ S++    HVCG S+L   W LTAAHCF  ++D+ +
Sbjct: 33  CGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETYSDLSD 92

Query: 251 ---WKVRAGSDKLGSFPSLAVAK-------IIIIEFNPMYPKDN--DIALMKLQFPLTFS 298
              W V+ G  +L S PS    +       +  I  +P Y  ++  DIAL+KL  P+T++
Sbjct: 93  PSGWMVQFG--QLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYT 150

Query: 299 GTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQ-ASVQVIDSTRCN---AD 354
             ++PICL     E    T  W+ GWG+ K++    S   LQ   V +I+++ CN     
Sbjct: 151 KHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLK 210

Query: 355 DAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPL-MYQSDQWHVVGIVSWGYGCGGPSTPGV 413
            +++ ++   M+CAG  +GG D C GDSGGPL   ++  W+ +G+VSWG GCG P+ PGV
Sbjct: 211 YSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGV 270

Query: 414 YTKVSAYLNWI 424
           YT +S +  WI
Sbjct: 271 YTNISHHFEWI 281


>gi|21614531 testisin isoform 2 [Homo sapiens]
          Length = 312

 Score =  180 bits (456), Expect = 3e-45
 Identities = 98/249 (39%), Positives = 143/249 (57%), Gaps = 17/249 (6%)

Query: 191 CGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKH-TDVF 249
           CG+ + T R+VGGE+A +  WPWQ S++    HVCG S+L   W LTAAHCF    +D  
Sbjct: 33  CGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDPS 92

Query: 250 NWKVRAGSDKLGSFPSLAVAK-------IIIIEFNPMYPKDN--DIALMKLQFPLTFSGT 300
            W V+ G  +L S PS    +       +  I  +P Y  ++  DIAL+KL  P+T++  
Sbjct: 93  GWMVQFG--QLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKH 150

Query: 301 VRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQ-ASVQVIDSTRCN---ADDA 356
           ++PICL     E    T  W+ GWG+ K++    S   LQ   V +I+++ CN      +
Sbjct: 151 IQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYS 210

Query: 357 YQGEVTEKMMCAGIPEGGVDTCQGDSGGPL-MYQSDQWHVVGIVSWGYGCGGPSTPGVYT 415
           ++ ++   M+CAG  +GG D C GDSGGPL   ++  W+ +G+VSWG GCG P+ PGVYT
Sbjct: 211 FRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYT 270

Query: 416 KVSAYLNWI 424
            +S +  WI
Sbjct: 271 NISHHFEWI 279


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  179 bits (454), Expect = 4e-45
 Identities = 96/260 (36%), Positives = 143/260 (55%), Gaps = 13/260 (5%)

Query: 181 GSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAH 240
           GS  +    ACG+     R+VGG++     WPWQVSIQ +  H CGGS++   WVLTAAH
Sbjct: 16  GSQRAKAATACGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTAAH 75

Query: 241 CFRKHTDVFNWKVRAGSDKL-GSFPSLAVAKIIIIEFNPMY---PKDNDIALMKLQFPLT 296
           CFR  ++   ++V  G+ +L    P    A++  +E NP+Y       D+AL++L+ P+ 
Sbjct: 76  CFRNTSETSLYQVLLGARQLVQPGPHAMYARVRQVESNPLYQGTASSADVALVELEAPVP 135

Query: 297 FSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQ-ASVQVIDSTRCN--- 352
           F+  + P+CLP            W+ GWG   +        +LQ  +V +ID+ +CN   
Sbjct: 136 FTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLY 195

Query: 353 ---ADDAYQGE-VTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQ-WHVVGIVSWGYGCGG 407
               +  YQ + +   M+CAG  EG  D C+GDSGGPL+    Q W   G++SWG GC  
Sbjct: 196 SKDTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQAGVISWGEGCAR 255

Query: 408 PSTPGVYTKVSAYLNWIYNV 427
            + PGVY +V+A+ NWI+ +
Sbjct: 256 QNRPGVYIRVTAHHNWIHRI 275


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  178 bits (452), Expect = 7e-45
 Identities = 89/232 (38%), Positives = 141/232 (60%), Gaps = 8/232 (3%)

Query: 199 RVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSD 258
           R+VGG EAS   +PWQ S++ +K+H CG +I++  W+++AAHCF +  D   W    G+ 
Sbjct: 202 RIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDPTKWVAYVGAT 261

Query: 259 KL-GSFPSLAVAKIIIIEFNPMYPKDN---DIALMKLQFPLTFSGTVRPICLPFFDEELT 314
            L GS  S   A+++ I  +P+Y  D    D+A+++L  PL F   ++P+CLP       
Sbjct: 262 YLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATHIFP 321

Query: 315 PATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGG 374
           P+    I GWG+ K++     ++L +A+V+++D   C +   Y   +T++M+CAG  +G 
Sbjct: 322 PSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS--LYGHSLTDRMVCAGYLDGK 379

Query: 375 VDTCQGDSGGPLMYQ--SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 424
           VD+CQGDSGGPL+ +  S ++ + GIVSWG GC     PGVY +V+   +WI
Sbjct: 380 VDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWI 431



 Score =  173 bits (438), Expect = 3e-43
 Identities = 93/231 (40%), Positives = 131/231 (56%), Gaps = 8/231 (3%)

Query: 199  RVVGGEEASVDSWPWQVSIQYDK-QHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGS 257
            R+VGG  A    WPWQVS+   + +H CG  ++   W+L+AAHCF  + D   W    G+
Sbjct: 826  RIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGT 885

Query: 258  DKLGSFPSLA--VAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTP 315
              L         VA+I    F  +Y  D D+AL++L  P+  S  VRPICLP        
Sbjct: 886  PFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRPPD 945

Query: 316  ATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGV 375
             T   I GWG  ++ GG M+  L +A+V+++    C     Y  +++ +M+CAG P+GGV
Sbjct: 946  GTRCVITGWGSVRE-GGSMARQLQKAAVRLLSEQTCRR--FYPVQISSRMLCAGFPQGGV 1002

Query: 376  DTCQGDSGGPLMYQ--SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 424
            D+C GD+GGPL  +  S +W + G+ SWGYGCG P  PGVYT+V+A   WI
Sbjct: 1003 DSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWI 1053



 Score =  167 bits (422), Expect = 2e-41
 Identities = 88/245 (35%), Positives = 139/245 (56%), Gaps = 15/245 (6%)

Query: 196 KTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRA 255
           K  RVVGG  A+    PWQVS++   +H CG +++   W+L+AAHCF  HT V   +   
Sbjct: 500 KPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCF-NHTKVEQVRAHL 558

Query: 256 GSDKL----GSFPSLAVAKIIIIEFNPMYPK---DNDIALMKLQFPLTFSGTVRPICLPF 308
           G+  L    GS   + + ++++   +P+Y     D D+A+++L  PL F+  ++P+CLP 
Sbjct: 559 GTASLLGLGGSPVKIGLRRVVL---HPLYNPGILDFDLAVLELASPLAFNKYIQPVCLPL 615

Query: 309 FDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCA 368
             ++        I GWG T++      ++L +ASV +ID   C+    Y   +T++M+CA
Sbjct: 616 AIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSV--LYNFSLTDRMICA 673

Query: 369 GIPEGGVDTCQGDSGGPLMYQS--DQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYN 426
           G  EG VD+CQGDSGGPL  +     +++ GIVSWG GC     PGVYT+++    WI  
Sbjct: 674 GFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILE 733

Query: 427 VWKAE 431
           +  ++
Sbjct: 734 IMSSQ 738


>gi|11545839 protease, serine, 22 [Homo sapiens]
          Length = 317

 Score =  178 bits (452), Expect = 7e-45
 Identities = 106/251 (42%), Positives = 146/251 (58%), Gaps = 15/251 (5%)

Query: 190 ACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTD-V 248
           ACGK  +  RVVGGE+++   WPW VSIQ +  H C GS+L   WV+TAAHCF+ + +  
Sbjct: 40  ACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKP 99

Query: 249 FNWKVRAGSDKLGSFPSLAVAKIII--IEFNPMYPKDN----DIALMKLQFPLTFSGTVR 302
           + + V  G+ +LG+ P     K+ +  +E +P+Y        DIAL++L+  + FS  V 
Sbjct: 100 YLFSVLLGAWQLGN-PGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVL 158

Query: 303 PICLPFFDEELTPATPLWIIGWGFTKQNGGKM--SDILLQASVQVIDSTRCNA---DDAY 357
           PICLP     L P T  WI GWG + Q+G  +     L +  V +IDS  C+      A 
Sbjct: 159 PICLPDASIHLPPNTHCWISGWG-SIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAG 217

Query: 358 QGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD-QWHVVGIVSWGYGCGGPSTPGVYTK 416
           QG +TE M+CAG  EG  D C GDSGGPLM Q D  W + GI+SWG GC   + PGVY  
Sbjct: 218 QGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYIS 277

Query: 417 VSAYLNWIYNV 427
           +SA+ +W+  +
Sbjct: 278 LSAHRSWVEKI 288


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score =  174 bits (441), Expect = 1e-43
 Identities = 125/381 (32%), Positives = 189/381 (49%), Gaps = 45/381 (11%)

Query: 71   IPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDN 130
            + R   CDGE DC    DE  CV        +++ ++   S L V  +AT +    C D 
Sbjct: 668  VSRDLWCDGEADCSDSSDEWDCV-------TLSINVNSS-SFLMVHRAATEH--HVCADG 717

Query: 131  FTEALAETACRQMGYSR--AVEIGPDQDLDVVEITENSQ----------ELRMRNSSGPC 178
            + E L++ AC+QMG       ++  +Q+ +   +T +S           EL +   S  C
Sbjct: 718  WQEILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQS--C 775

Query: 179  LSGSLVSLHCLA--CGK---SLKTPRVVGGEEASVDSWPWQVSIQYDKQ-HVCGGSILDP 232
             S S +SL C    CG+   +    R++GG  +    WPWQ S+Q +   H+CG  ++  
Sbjct: 776  ESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAK 835

Query: 233  HWVLTAAHCFRKHTDVFNWKVRAGSDKLGS---FPSLAVAKIIIIEFNPMYPK---DNDI 286
             WVLT AHCF    +   WKV  G + L     F      K II+  +P Y +   D DI
Sbjct: 836  KWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIIL--HPRYSRAVVDYDI 893

Query: 287  ALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVI 346
            ++++L   ++ +G VRP+CLP  ++ L P T  +I GWG     G KM   L +  V++I
Sbjct: 894  SIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWGHM---GNKMPFKLQEGEVRII 950

Query: 347  DSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQ--SDQWHVVGIVSWGYG 404
                C +    +  +T +M+CAG   G VD+C GDSGGPL+ +    +W + G+ SWG  
Sbjct: 951  SLEHCQSYFDMK-TITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSV 1009

Query: 405  CGGPST-PGVYTKVSAYLNWI 424
            C      PGVY+ VS ++ WI
Sbjct: 1010 CFSKVLGPGVYSNVSYFVEWI 1030



 Score = 30.0 bits (66), Expect = 4.3
 Identities = 12/22 (54%), Positives = 14/22 (63%)

Query: 71  IPRKQLCDGELDCPLGEDEEHC 92
           IP    CDG+ DC  G DEE+C
Sbjct: 393 IPSTFQCDGDEDCKDGSDEENC 414


>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
           sapiens]
          Length = 418

 Score =  174 bits (440), Expect = 2e-43
 Identities = 91/240 (37%), Positives = 130/240 (54%), Gaps = 6/240 (2%)

Query: 190 ACGKS---LKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHT 246
           +CGK    L   R+  G  A   +WPWQ S+QYD  H CG +++   W++TAAHCF+K+ 
Sbjct: 174 SCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYK 233

Query: 247 DVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICL 306
           +   W V  G+          V + II E      ++ DIA++++   +TFS  +R ICL
Sbjct: 234 NPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICL 293

Query: 307 PFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMM 366
           P       P   + I G+G     GG+  + L +A V++I    C     Y  ++   M 
Sbjct: 294 PEASASFQPNLTVHITGFG-ALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMF 352

Query: 367 CAGIPEGGVDTCQGDSGGPLMYQ--SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 424
           CAG  EG  D C+GDSGGPL+ +   D W+++GIVSWG  CG    PGVYT+V+ Y NWI
Sbjct: 353 CAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWI 412


>gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo
           sapiens]
          Length = 421

 Score =  174 bits (440), Expect = 2e-43
 Identities = 91/240 (37%), Positives = 130/240 (54%), Gaps = 6/240 (2%)

Query: 190 ACGKS---LKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHT 246
           +CGK    L   R+  G  A   +WPWQ S+QYD  H CG +++   W++TAAHCF+K+ 
Sbjct: 177 SCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYK 236

Query: 247 DVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICL 306
           +   W V  G+          V + II E      ++ DIA++++   +TFS  +R ICL
Sbjct: 237 NPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICL 296

Query: 307 PFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMM 366
           P       P   + I G+G     GG+  + L +A V++I    C     Y  ++   M 
Sbjct: 297 PEASASFQPNLTVHITGFG-ALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMF 355

Query: 367 CAGIPEGGVDTCQGDSGGPLMYQ--SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 424
           CAG  EG  D C+GDSGGPL+ +   D W+++GIVSWG  CG    PGVYT+V+ Y NWI
Sbjct: 356 CAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWI 415


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  171 bits (434), Expect = 9e-43
 Identities = 99/238 (41%), Positives = 132/238 (55%), Gaps = 12/238 (5%)

Query: 199 RVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSD 258
           R+ GG  A    WPWQVSI Y+  HVCGGS++   WVL+AAHCF        ++V+ G+ 
Sbjct: 44  RITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAH 103

Query: 259 KLGSFPSLA-VAKIIIIEFNPMYPKD---NDIALMKLQFPLTFSGTVRPICLPFFDEELT 314
           +L S+   A V+ +  I  +P Y ++    DIAL++L  P+TFS  +RPICLP  +    
Sbjct: 104 QLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFP 163

Query: 315 PATPLWIIGWGFTKQNGGKMS-DILLQASVQVIDSTRCNA---DDAYQGE---VTEKMMC 367
                 + GWG    +   ++   L Q  V +I    CN     DA   E   V E M+C
Sbjct: 164 NGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVC 223

Query: 368 AGIPEGGVDTCQGDSGGPLMYQSD-QWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 424
           AG  EGG D CQGDSGGPL    +  W++ GIVSWG  CG  + PGVYT  S+Y +WI
Sbjct: 224 AGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWI 281


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.442 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,028,844
Number of Sequences: 37866
Number of extensions: 836603
Number of successful extensions: 2616
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 191
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 1631
Number of HSP's gapped (non-prelim): 475
length of query: 432
length of database: 18,247,518
effective HSP length: 105
effective length of query: 327
effective length of database: 14,271,588
effective search space: 4666809276
effective search space used: 4666809276
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.