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Search of human proteins with 145309328
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|145309328 papilin [Homo sapiens]
(1251 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|145309328 papilin [Homo sapiens] 2698 0.0
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 363 e-100
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 351 3e-96
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 342 2e-93
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 328 3e-89
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 308 3e-83
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 300 7e-81
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 284 3e-76
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 281 2e-75
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 273 1e-72
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 269 1e-71
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 265 2e-70
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 261 3e-69
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 259 9e-69
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 256 7e-68
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 234 5e-61
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 233 1e-60
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 230 6e-60
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 230 6e-60
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 228 2e-59
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 225 2e-58
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 215 2e-55
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 215 2e-55
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 200 8e-51
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 200 8e-51
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 200 8e-51
gi|226442878 ADAMTS-like 5 [Homo sapiens] 198 3e-50
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 188 3e-47
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 162 2e-39
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 161 3e-39
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 2698 bits (6994), Expect = 0.0
Identities = 1251/1251 (100%), Positives = 1251/1251 (100%)
Query: 1 MRLLLLVPLLLAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDG 60
MRLLLLVPLLLAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDG
Sbjct: 1 MRLLLLVPLLLAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDG 60
Query: 61 GSSCVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNC 120
GSSCVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNC
Sbjct: 61 GSSCVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNC 120
Query: 121 IPKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGT 180
IPKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGT
Sbjct: 121 IPKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGT 180
Query: 181 TCYPVAGTFDANDLSRAVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAPER 240
TCYPVAGTFDANDLSRAVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAPER
Sbjct: 181 TCYPVAGTFDANDLSRAVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAPER 240
Query: 241 LHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSR 300
LHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSR
Sbjct: 241 LHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSR 300
Query: 301 LVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSV 360
LVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSV
Sbjct: 301 LVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSV 360
Query: 361 YCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRS 420
YCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRS
Sbjct: 361 YCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRS 420
Query: 421 VTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRR 480
VTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRR
Sbjct: 421 VTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRR 480
Query: 481 QVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQEVPSMQDVHTPASNPWMPLGPQESP 540
QVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQEVPSMQDVHTPASNPWMPLGPQESP
Sbjct: 481 QVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQEVPSMQDVHTPASNPWMPLGPQESP 540
Query: 541 ASDSRGQWWAAQEHPSARGDHRGERGDPRGDQGTHLSALGPAPSLQQPPYQQPLRSGSGP 600
ASDSRGQWWAAQEHPSARGDHRGERGDPRGDQGTHLSALGPAPSLQQPPYQQPLRSGSGP
Sbjct: 541 ASDSRGQWWAAQEHPSARGDHRGERGDPRGDQGTHLSALGPAPSLQQPPYQQPLRSGSGP 600
Query: 601 HDCRHSPHGCCPDGHTASLGPQWQGCPGAPCQQSRYGCCPDRVSVAEGPHHAGCTKSYGG 660
HDCRHSPHGCCPDGHTASLGPQWQGCPGAPCQQSRYGCCPDRVSVAEGPHHAGCTKSYGG
Sbjct: 601 HDCRHSPHGCCPDGHTASLGPQWQGCPGAPCQQSRYGCCPDRVSVAEGPHHAGCTKSYGG 660
Query: 661 DSTGGMPRSRAVASTVHNTHQPQAQQNEPSECRGSQFGCCYDNVATAAGPLGEGCVGQPS 720
DSTGGMPRSRAVASTVHNTHQPQAQQNEPSECRGSQFGCCYDNVATAAGPLGEGCVGQPS
Sbjct: 661 DSTGGMPRSRAVASTVHNTHQPQAQQNEPSECRGSQFGCCYDNVATAAGPLGEGCVGQPS 720
Query: 721 HAYPVRCLLPSAHGSCADWAARWYFVASVGQCNRFWYGGCHGNANNFASEQECMSSCQGS 780
HAYPVRCLLPSAHGSCADWAARWYFVASVGQCNRFWYGGCHGNANNFASEQECMSSCQGS
Sbjct: 721 HAYPVRCLLPSAHGSCADWAARWYFVASVGQCNRFWYGGCHGNANNFASEQECMSSCQGS 780
Query: 781 LHGPRRPQPGASGRSTHTDGGGSSPAGEQEPSQHRTGAAVQRKPWPSGGLWRQDQQPGPG 840
LHGPRRPQPGASGRSTHTDGGGSSPAGEQEPSQHRTGAAVQRKPWPSGGLWRQDQQPGPG
Sbjct: 781 LHGPRRPQPGASGRSTHTDGGGSSPAGEQEPSQHRTGAAVQRKPWPSGGLWRQDQQPGPG 840
Query: 841 EAPHTQAFGEWPWGQELGSRAPGLGGDAGSPAPPFHSSSYRISLAGVEPSLVQAALGQLV 900
EAPHTQAFGEWPWGQELGSRAPGLGGDAGSPAPPFHSSSYRISLAGVEPSLVQAALGQLV
Sbjct: 841 EAPHTQAFGEWPWGQELGSRAPGLGGDAGSPAPPFHSSSYRISLAGVEPSLVQAALGQLV 900
Query: 901 RLSCSDDTAPESQAAWQKDGQPISSDRHRLQFDGSLIIHPLQAEDAGTYSCGSTRPGRDS 960
RLSCSDDTAPESQAAWQKDGQPISSDRHRLQFDGSLIIHPLQAEDAGTYSCGSTRPGRDS
Sbjct: 901 RLSCSDDTAPESQAAWQKDGQPISSDRHRLQFDGSLIIHPLQAEDAGTYSCGSTRPGRDS 960
Query: 961 QKIQLRIIGGDMAVLSEAELSRFPQPRDPAQDFGQAGAAGPLGAIPSSHPQPANRLRLDQ 1020
QKIQLRIIGGDMAVLSEAELSRFPQPRDPAQDFGQAGAAGPLGAIPSSHPQPANRLRLDQ
Sbjct: 961 QKIQLRIIGGDMAVLSEAELSRFPQPRDPAQDFGQAGAAGPLGAIPSSHPQPANRLRLDQ 1020
Query: 1021 NQPRVVDASPGQRIRMTCRAEGFPPPAIEWQRDGQPVSSPRHQLQPDGSLVISRVAVEDG 1080
NQPRVVDASPGQRIRMTCRAEGFPPPAIEWQRDGQPVSSPRHQLQPDGSLVISRVAVEDG
Sbjct: 1021 NQPRVVDASPGQRIRMTCRAEGFPPPAIEWQRDGQPVSSPRHQLQPDGSLVISRVAVEDG 1080
Query: 1081 GFYTCVAFNGQDRDQRWVQLRVLGELTISGLPPTVTVPEGDTARLLCVVAGESVNIRWSR 1140
GFYTCVAFNGQDRDQRWVQLRVLGELTISGLPPTVTVPEGDTARLLCVVAGESVNIRWSR
Sbjct: 1081 GFYTCVAFNGQDRDQRWVQLRVLGELTISGLPPTVTVPEGDTARLLCVVAGESVNIRWSR 1140
Query: 1141 NGLPVQADGHRVHQSPDGTLLIYNLRARDEGSYTCSAYQGSQAVSRSTEVKVVSPAPTAQ 1200
NGLPVQADGHRVHQSPDGTLLIYNLRARDEGSYTCSAYQGSQAVSRSTEVKVVSPAPTAQ
Sbjct: 1141 NGLPVQADGHRVHQSPDGTLLIYNLRARDEGSYTCSAYQGSQAVSRSTEVKVVSPAPTAQ 1200
Query: 1201 PRDPGRDCVDQPELANCDLILQAQLCGNEYYSSFCCASCSRFQPHAQPIWQ 1251
PRDPGRDCVDQPELANCDLILQAQLCGNEYYSSFCCASCSRFQPHAQPIWQ
Sbjct: 1201 PRDPGRDCVDQPELANCDLILQAQLCGNEYYSSFCCASCSRFQPHAQPIWQ 1251
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 363 bits (933), Expect = e-100
Identities = 202/538 (37%), Positives = 273/538 (50%), Gaps = 70/538 (13%)
Query: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGSS-CVGPARSHRSCRTESCPDGARDFR 87
WGPWS W CSRTCGGGVS R C S GG C+G + +RSC T+ CP G+RDFR
Sbjct: 561 WGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFR 620
Query: 88 AEQCAEFDGAEFQGRRYRWLPYYSAPNK-CELNCIPKGENFYYKHREAVVDGTPCEPGKR 146
+QCA+FD F+G+ Y W PY K C LNC+ +G NFY + AV+DGT C
Sbjct: 621 EKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSL 680
Query: 147 DVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDLSR---------- 196
D+C++G C+ VGCD+ L S +ED+C CGGDG+TC + G F+ + L R
Sbjct: 681 DICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFN-DSLPRGGYMEVVQIP 739
Query: 197 ------------------AVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAP 238
A+K+ +YY+NG WTI+ R A T HY+R + P
Sbjct: 740 RGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTD---EP 796
Query: 239 ERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSP-----GFSWSHGSWSDCSAEC 293
E L A GPTSE L++ ++ QE N G+ Y++++P+ R GF+W+H WS+CSA C
Sbjct: 797 ESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTWNHQPWSECSATC 856
Query: 294 GGGHQSRLVFC--TIDHEAYPDHMCQRQPRPAD-RRSCNLHPCPETKRWKAGPWAPCSAS 350
GG Q + V C D+ ++ C +P + +R+CN PCP W G W CS +
Sbjct: 857 AGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP--PEWFIGDWLECSKT 914
Query: 351 CGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC-AAWSPEPWGECS 409
C GG ++R+V CI G +E ++ + C L +P + CN Q C W W EC+
Sbjct: 915 CDGGMRTRAVLCIRKIGPSEEETLDYSGC--LTHRPVEKEPCNNQSCPPQWVALDWSECT 972
Query: 410 VSCGVGVRKRSVTCRGERGSLLHTAA-CSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGL 468
CG G + R V C+ S AA C E +PP+ C CP W G WG
Sbjct: 973 PKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCP---PPRWVTGDWGQ 1029
Query: 469 CSKSCSSGTRRRQVIC-------------AIGPPS--HCGSLQHSKPVDVEPCNTQPC 511
CS C G + R V C + PPS C S S P+ NT+ C
Sbjct: 1030 CSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPIS----NTEEC 1083
Score = 36.2 bits (82), Expect = 0.20
Identities = 17/68 (25%), Positives = 28/68 (41%)
Query: 1172 SYTCSAYQGSQAVSRSTEVKVVSPAPTAQPRDPGRDCVDQPELANCDLILQAQLCGNEYY 1231
SYT A R ++ + P +C D ++A C L+L+ + C Y+
Sbjct: 1047 SYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAYF 1106
Query: 1232 SSFCCASC 1239
CC +C
Sbjct: 1107 RQMCCKTC 1114
Score = 33.5 bits (75), Expect = 1.3
Identities = 22/73 (30%), Positives = 26/73 (35%), Gaps = 7/73 (9%)
Query: 448 CVHEDC------PLLSDQAWHVGT-WGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKP 500
C DC P D W + WG CS++C G C PS G +
Sbjct: 542 CYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGER 601
Query: 501 VDVEPCNTQPCHL 513
CNT PC L
Sbjct: 602 KRYRSCNTDPCPL 614
Score = 32.0 bits (71), Expect = 3.8
Identities = 17/59 (28%), Positives = 21/59 (35%)
Query: 35 WSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARSHRSCRTESCPDGARDFRAEQCAE 93
W CS CG G R C S S C+ R + ES D E+C +
Sbjct: 1027 WGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECKD 1085
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 351 bits (900), Expect = 3e-96
Identities = 195/529 (36%), Positives = 261/529 (49%), Gaps = 49/529 (9%)
Query: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-GGSSCVGPARSHRSCRTESCPDGARDFR 87
WGPW+ W CSRTCGGGVS R C S R GG C+G R HRSC T+ CP G++DFR
Sbjct: 550 WGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFR 609
Query: 88 AEQCAEFDGAEFQGRRYRWLPYYSAPNK-CELNCIPKGENFYYKHREAVVDGTPCEPGKR 146
QC+EFD F+G+ Y+W Y K C L C+ +G NFY + AVVDGTPC P
Sbjct: 610 EVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPDTV 669
Query: 147 DVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDA--------------- 191
D+CV G C+ VGCD L S +EDKC CGGDG+ C + G F
Sbjct: 670 DICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPK 729
Query: 192 -------NDLSR-----AVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAPE 239
DL+ A+K + L G LP A T +G + +
Sbjct: 730 GSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQGPD---QVQ 786
Query: 240 RLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPS-PGFSWSHGSWSDCSAECGGGHQ 298
L A GP + L++ ++++ P + Y ++ P+ R S P +SW + W+ CSA+C GG Q
Sbjct: 787 SLEALGPINASLIVMVLARTELPALRYRFNAPIARDSLPPYSWHYAPWTKCSAQCAGGSQ 846
Query: 299 SRLVFCT--IDHEAYPDHMCQRQPR-PADRRSCNLHPCPETKRWKAGPWAPCSASCGGGS 355
+ V C +D A H C + P +R+CN PCP W G W+ CS SC G
Sbjct: 847 VQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPD--WVVGNWSLCSRSCDAGV 904
Query: 356 QSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAA-WSPEPWGECSVSCGV 414
+SRSV C A ++A++++ C +PP ++AC+ C W+ W EC+ SCG
Sbjct: 905 RSRSVVCQRRVSAAEEKALDDSACP--QPRPPVLEACHGPTCPPEWAALDWSECTPSCGP 962
Query: 415 GVRKRSVTCRG-ERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSC 473
G+R R V C+ + + L A CS +PP T C CP W G WG CS C
Sbjct: 963 GLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCP---PARWVAGEWGECSAQC 1019
Query: 474 SSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQEVPSMQD 522
G R+R V C SH G H + P TQ C + P+ D
Sbjct: 1020 GVGQRQRSVRCT----SHTGQASHECTEALRPPTTQQCEAKCDSPTPGD 1064
Score = 40.8 bits (94), Expect = 0.008
Identities = 16/64 (25%), Positives = 33/64 (51%)
Query: 1176 SAYQGSQAVSRSTEVKVVSPAPTAQPRDPGRDCVDQPELANCDLILQAQLCGNEYYSSFC 1235
++++ ++A+ T + + + P D +C D ++A C L+L+ Q C Y+ C
Sbjct: 1037 ASHECTEALRPPTTQQCEAKCDSPTPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMC 1096
Query: 1236 CASC 1239
C +C
Sbjct: 1097 CKTC 1100
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 342 bits (876), Expect = 2e-93
Identities = 190/532 (35%), Positives = 263/532 (49%), Gaps = 57/532 (10%)
Query: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-GGSSCVGPARSHRSCRTESCPDGARDFR 87
W WS+WS CSRTCGGGV F+ER C + + GG C G +R ++ C C + + DFR
Sbjct: 592 WSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFR 651
Query: 88 AEQCAEFDGAEFQGRRYRWLPYYSAP--NKCELNCIPKGENFYYKHREAVVDGTPCEPGK 145
A+QCAE++ F+G Y+W PY ++C+L C + F++ V DGTPC P K
Sbjct: 652 AQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNK 711
Query: 146 RDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTC----------------YPV---- 185
DVC+DG C +VGCDHEL S D C C GD +TC YPV
Sbjct: 712 NDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIP 771
Query: 186 --AGTFDANDLS-----RAVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAP 238
A + + +L AV+++ +YYL G W+I+ P A T Y+R P
Sbjct: 772 AGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFN---RP 828
Query: 239 ERLHARGPTSEPLVIELISQEPNPGVHYEYHLPL-------RRPSPGFSWSHGSWSDCSA 291
ERL+A GPT+E LV E++ Q NPG+ ++Y LP P ++WS S+CS
Sbjct: 829 ERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQ-SECSV 887
Query: 292 ECGGGHQSRLVFCTIDHEAYPDH-MCQRQPRPA-DRRSCNLHPCPETKRWKAGPWAPCSA 349
CGGG+ + C D + C + +P + + CN CP W G W+ CS
Sbjct: 888 SCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAY--WMPGEWSTCSK 945
Query: 350 SCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAA-WSPEPWGEC 408
+C GG QSR + C+ +EAV + C P +QACN C WS PW +C
Sbjct: 946 ACAGGQQSRKIQCVQKKPFQKEEAVLHSLCP--VSTPTQVQACNSHACPPQWSLGPWSQC 1003
Query: 409 SVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGL 468
S +CG GVRKR + C+G L + C+ RP L E CV CP S W +W
Sbjct: 1004 SKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSE 1063
Query: 469 CSKSCSSGTRRRQVICA---------IGPPSHCGSLQHSKPVDVEPCNTQPC 511
CS +C G R+R++ C+ P C +++ E CN + C
Sbjct: 1064 CSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRAC 1115
Score = 138 bits (347), Expect = 4e-32
Identities = 92/279 (32%), Positives = 119/279 (42%), Gaps = 35/279 (12%)
Query: 281 WSHGSWSDCSAECGGGHQSRLVFCTID-----HEAYPDHMCQRQPRPADRRSCNLHPCPE 335
W G WS CS C GG QSR + C EA +C P ++CN H CP
Sbjct: 935 WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVST-PTQVQACNSHACPP 993
Query: 336 TKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQ 395
+W GPW+ CS +CG G + R + C S E + E++C LP +P + C L
Sbjct: 994 --QWSLGPWSQCSKTCGRGVRKRELLCKGSAA----ETLPESQCTSLP-RPELQEGCVLG 1046
Query: 396 RCAA-----WSPEPWGECSVSCGVGVRKRSVTC--RGERGSLLH--TAACSLEDRP--PL 444
RC W W ECS +CG+GVRKR + C +G +G L+ C +P L
Sbjct: 1047 RCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDL 1106
Query: 445 TEPCVHEDCPLLSDQ----AWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKP 500
E C CP W+ W C+ +C G + R V C L H KP
Sbjct: 1107 EETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKP 1166
Query: 501 VDVEPCNTQPCHLPQ--EVPSMQDVHTPASNPWMPLGPQ 537
+ CNT C P+ E PS D W L PQ
Sbjct: 1167 PVLRACNTNFCPAPEKREDPSCVDFFN-----WCHLVPQ 1200
Score = 78.2 bits (191), Expect = 5e-14
Identities = 51/172 (29%), Positives = 76/172 (44%), Gaps = 21/172 (12%)
Query: 241 LHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSR 300
L +G +E L + P P + L + W SWS+CSA CG G + R
Sbjct: 1016 LLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKR 1075
Query: 301 LVFCTIDHE-----AYPDHMCQRQPRP-------ADRRSCNLHPCPE-TKRWKAGPWAPC 347
+ C+ +P+ C+ +P +RR+C HP W + PW C
Sbjct: 1076 EMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQC 1135
Query: 348 SASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAA 399
+ +CGGG Q+RSV+C +Q+ + C L KPP ++ACN C A
Sbjct: 1136 TVTCGGGVQTRSVHC-------VQQGRPSSSCL-LHQKPPVLRACNTNFCPA 1179
Score = 37.4 bits (85), Expect = 0.090
Identities = 20/48 (41%), Positives = 24/48 (50%), Gaps = 3/48 (6%)
Query: 35 WSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARSH--RSCRTESCP 80
W C+ TCGGGV R C Q R SSC+ + R+C T CP
Sbjct: 1132 WQQCTVTCGGGVQTRSVHCVQQGRP-SSSCLLHQKPPVLRACNTNFCP 1178
Score = 35.8 bits (81), Expect = 0.26
Identities = 23/63 (36%), Positives = 29/63 (46%), Gaps = 4/63 (6%)
Query: 274 RPSPGFSWSHGS-WSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHP 332
RP G WS S WS+CS CGGG + + C Y C R + CN++P
Sbjct: 586 RPIHG-QWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSR--IYQLCNINP 642
Query: 333 CPE 335
C E
Sbjct: 643 CNE 645
Score = 31.6 bits (70), Expect = 5.0
Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 5/47 (10%)
Query: 1195 PAPTAQPRDPGRDCVDQPELANCDLILQAQLCGNEYYSSFCCASCSR 1241
PAP + DP CVD C L+ Q +C +++Y CC SC+R
Sbjct: 1178 PAPEKR-EDPS--CVDFFNW--CHLVPQHGVCNHKFYGKQCCKSCTR 1219
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 328 bits (840), Expect = 3e-89
Identities = 202/566 (35%), Positives = 276/566 (48%), Gaps = 64/566 (11%)
Query: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-GGSSCVGPARSHRSCRTESCPDGARDFR 87
W WS WSPCSRTCGGGVS R R C + + GG C G R+ + C ++ CP + DFR
Sbjct: 589 WSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFR 648
Query: 88 AEQCAEFDGAEFQGRRYRWLPYYSAPNK--CELNCIPKGENFYYKHREAVVDGTPCEPGK 145
A QCAE + F+GR Y+W PY ++ C+L CI +G +F++ V DGTPC
Sbjct: 649 AAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDS 708
Query: 146 RDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDLSR--------- 196
R+VC+DG C VGCD+ L S ED C C G+ + C G + + +
Sbjct: 709 RNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIP 768
Query: 197 ------------------AVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAP 238
+V+N YYLNGHWT++ + T Y R P
Sbjct: 769 SGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYN---EP 825
Query: 239 ERLHARGPTSEPLVIELISQEPNPGVHYEYHLPL----RRP--SPGFSWSHGSWSDCSAE 292
E L A GPT+E L++EL+ Q NPGV +EY +P ++P P ++W+ S+CS
Sbjct: 826 ENLIATGPTNETLIVELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVR-SECSVS 884
Query: 293 CGGGHQSRLVFCTIDHEAYPD-HMCQRQPRPADRR-SCNLHPCPETKRWKAGPWAPCSAS 350
CGGG + C D + + C + RP C + CP + W G W+ CS +
Sbjct: 885 CGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPS--WSVGNWSACSRT 942
Query: 351 CGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCA-AWSPEPWGECS 409
CGGG+QSR V C E V + C P + QACN Q C AWS PW ECS
Sbjct: 943 CGGGAQSRPVQCTRRVHYD-SEPVPASLCP--QPAPSSRQACNSQSCPPAWSAGPWAECS 999
Query: 410 VSCGVGVRKRSVTCRGE----RGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGT 465
+CG G RKR+V C+ R LL A C+ E +P + E C+ + C W V
Sbjct: 1000 HTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSA 1059
Query: 466 WGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQEVPSMQDVHT 525
W CS +C GT++R + CA S G + E + + HLP+ PS++
Sbjct: 1060 WSQCSVTCERGTQKRFLKCAEKYVS--GKYR-------ELASKKCSHLPK--PSLELERA 1108
Query: 526 PASNPWMPLGPQESPASDSRGQWWAA 551
A P P P + A SRG W+A+
Sbjct: 1109 CAPLP-CPRHPPFAAAGPSRGSWFAS 1133
Score = 156 bits (394), Expect = 1e-37
Identities = 101/286 (35%), Positives = 130/286 (45%), Gaps = 31/286 (10%)
Query: 280 SWSHGSWSDCSAECGGGHQSRLVFCT----IDHEAYPDHMCQRQPRPADRRSCNLHPCPE 335
SWS G+WS CS CGGG QSR V CT D E P +C QP P+ R++CN CP
Sbjct: 930 SWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCP-QPAPSSRQACNSQSCPP 988
Query: 336 TKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQ 395
W AGPWA CS +CG G + R+V C S++ + + + +A C P KP +AC LQ
Sbjct: 989 A--WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEP-KPRMHEACLLQ 1045
Query: 396 RC-----AAWSPEPWGECSVSCGVGVRKRSVTCRGERGS----LLHTAACSLEDRPPLT- 445
RC W W +CSV+C G +KR + C + S L + CS +P L
Sbjct: 1046 RCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLEL 1105
Query: 446 -EPCVHEDCPLL--------SDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQ 496
C CP S +W W C+ SC G + R V C G G L
Sbjct: 1106 ERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLL 1165
Query: 497 HSKPVDVEPCNTQPCHLPQEVPSMQDVHTPASNPWMPLGPQESPAS 542
H KP CNT C + ++ +D W L PQ S
Sbjct: 1166 HQKPSASLACNTHFCPIAEK----KDAFCKDYFHWCYLVPQHGMCS 1207
Score = 72.0 bits (175), Expect = 3e-12
Identities = 48/158 (30%), Positives = 62/158 (39%), Gaps = 25/158 (15%)
Query: 257 SQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEA-----Y 311
+ EP P +H L W +WS CS C G Q R + C + +
Sbjct: 1031 TSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYREL 1090
Query: 312 PDHMCQRQPRPADR--RSCNLHPCPETK----------RWKAGPWAPCSASCGGGSQSRS 359
C P+P+ R+C PCP W A PW+ C+ASCGGG Q+RS
Sbjct: 1091 ASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRS 1150
Query: 360 VYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397
V C++ A L KP A ACN C
Sbjct: 1151 VQCLAGG--------RPASGCLLHQKPSASLACNTHFC 1180
Score = 44.7 bits (104), Expect = 6e-04
Identities = 28/74 (37%), Positives = 32/74 (43%), Gaps = 7/74 (9%)
Query: 13 PAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPC-----YSQRRDGGSSCVGP 67
P G KV +W WS CSRTCGGG R C Y S C P
Sbjct: 915 PVTGLVPCKVSACPPSWSV-GNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQP 973
Query: 68 ARSHR-SCRTESCP 80
A S R +C ++SCP
Sbjct: 974 APSSRQACNSQSCP 987
Score = 39.7 bits (91), Expect = 0.018
Identities = 25/73 (34%), Positives = 31/73 (42%), Gaps = 5/73 (6%)
Query: 12 APAPGSSAPKVRRQSDTWGPW--SQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPAR 69
AP P P + G W S WS C+ +CGGGV R C + R S C+ +
Sbjct: 1110 APLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRP-ASGCLLHQK 1168
Query: 70 SHRS--CRTESCP 80
S C T CP
Sbjct: 1169 PSASLACNTHFCP 1181
Score = 39.3 bits (90), Expect = 0.024
Identities = 20/61 (32%), Positives = 26/61 (42%), Gaps = 2/61 (3%)
Query: 274 RPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPC 333
+P+ G SWS CS CGGG R CT ++ C+ R + CN C
Sbjct: 583 KPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTL--KLCNSQKC 640
Query: 334 P 334
P
Sbjct: 641 P 641
Score = 35.8 bits (81), Expect = 0.26
Identities = 33/142 (23%), Positives = 49/142 (34%), Gaps = 31/142 (21%)
Query: 7 VPLLLAPAPGSSAPKVRRQSDTWGPWSQ--WSPCSRTCGGGVSFRERPCYSQRRDGGSSC 64
VP L P P S+ + WS W+ CS TCG G R C S +
Sbjct: 965 VPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQL 1024
Query: 65 VGPA--------RSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKC 116
+ A R H +C + C + ++ +WL SA ++C
Sbjct: 1025 LPDAVCTSEPKPRMHEACLLQRC-------------------HKPKKLQWL--VSAWSQC 1063
Query: 117 ELNCIPKGENFYYKHREAVVDG 138
+ C + + K E V G
Sbjct: 1064 SVTCERGTQKRFLKCAEKYVSG 1085
Score = 35.0 bits (79), Expect = 0.45
Identities = 22/70 (31%), Positives = 28/70 (40%), Gaps = 15/70 (21%)
Query: 332 PCPETKRWKA-GPWAPCSASCGGGSQSRSVYCIS---SDGAGIQEAVEEAECAGLPGKPP 387
P P W W+PCS +CGGG RS C + S G E G
Sbjct: 582 PKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCE-----------GSTR 630
Query: 388 AIQACNLQRC 397
++ CN Q+C
Sbjct: 631 TLKLCNSQKC 640
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 308 bits (788), Expect = 3e-83
Identities = 181/481 (37%), Positives = 241/481 (50%), Gaps = 61/481 (12%)
Query: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQR-RDGGSSCVGPARSHRSCRTESCPDGARDFR 87
W WS WS CSR+CG GV ER C + G CVG + R C ++CP G FR
Sbjct: 541 WSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFR 600
Query: 88 AEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEP--GK 145
QC+ FD ++G+ + W+P + N CEL+C P E F K R+AVVDGTPC
Sbjct: 601 HVQCSHFDAMLYKGQLHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRAS 660
Query: 146 RDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTF---------DANDLSR 196
RD+C++G C+ VGCD E+DS ED+C C G+G+TC+ V+GTF D +
Sbjct: 661 RDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPA 720
Query: 197 AVKNVR------------------GEYYLNGHWTIEAARALPAASTILHYERGAEGDLAP 238
+ +R +Y+LNG WTI+ A T Y R
Sbjct: 721 GAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNW---- 776
Query: 239 ERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRR------PSPGFSWSHGSWSDCSAE 292
E L + GPT EP+ I+L+ QE NPGVHYEY + P P FSW +G W+ C+
Sbjct: 777 ENLTSPGPTKEPVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVT 836
Query: 293 CGGGHQSRLVFCTIDHEAYP--DHMCQRQPRPAD-RRSCNLHPCPETKRWKAGPWAPCSA 349
CG G Q + V+C ++ +A P + C RP D +R C+ PCP RW AG W CS+
Sbjct: 837 CGRGVQRQNVYC-LERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP--ARWWAGEWQLCSS 893
Query: 350 SCG-GGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACN--LQRCAAWSPEPWG 406
SCG GG R+V CI S G Q A+E C LP +PP CN + A W+ W
Sbjct: 894 SCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLP-RPPTETPCNRHVPCPATWAVGNWS 952
Query: 407 ECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGTW 466
+CSV+CG G ++R+V C + G C +P C C W +GT
Sbjct: 953 QCSVTCGEGTQRRNVLCTNDTG-----VPCDEAQQPASEVTCSLPLC------RWPLGTL 1001
Query: 467 G 467
G
Sbjct: 1002 G 1002
Score = 145 bits (365), Expect = 3e-34
Identities = 99/290 (34%), Positives = 119/290 (41%), Gaps = 56/290 (19%)
Query: 236 LAPERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGG 295
LAP A GP ++PLV+ N G W G+WS+CS CG
Sbjct: 1394 LAPSLAEA-GPPADPLVVR------NAG-----------------WQAGNWSECSTTCGL 1429
Query: 296 GHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGS 355
G R V C+ D C RP R C+L PC W +G W+ CS SCGGGS
Sbjct: 1430 GAVWRPVRCSSGR----DEDCAPAGRPQPARRCHLRPCAT---WHSGNWSKCSRSCGGGS 1482
Query: 356 QSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVG 415
R V C+ + + C P KPPA + C Q C +W W ECS +CG G
Sbjct: 1483 SVRDVQCVDTRDL---RPLRPFHCQPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGG 1539
Query: 416 VRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSS 475
++R VTC C RP T PC C W VG WG CS C
Sbjct: 1540 EQQRLVTCP-------EPGLCEEALRPNTTRPCNTHPC-----TQWVVGPWGQCSGPCGG 1587
Query: 476 GTRRRQVICA---IGPP----SHCGSLQHSKPVDVEPCNTQPCHLPQEVP 518
G +RR V C G P CG + P PC T+ C P E P
Sbjct: 1588 GVQRRLVKCVNTQTGLPEEDSDQCG--HEAWPESSRPCGTEDCE-PVEPP 1634
Score = 36.6 bits (83), Expect = 0.15
Identities = 23/62 (37%), Positives = 28/62 (45%), Gaps = 7/62 (11%)
Query: 24 RQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQR----RDGGSSCVGPAR--SHRSCRTE 77
R TW WS CSR+CGGG S R+ C R GPA+ +HR C +
Sbjct: 1461 RPCATWHS-GNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQ 1519
Query: 78 SC 79
C
Sbjct: 1520 PC 1521
Score = 34.3 bits (77), Expect = 0.77
Identities = 39/151 (25%), Positives = 57/151 (37%), Gaps = 18/151 (11%)
Query: 383 PGKPPAI-----QACNLQRCA--AWSPEPWGEC-SVSCGVGVRKRSVTCRGERGSLLHTA 434
P PP + C LQ A A+ + C ++ C VG TC + + +
Sbjct: 460 PSVPPGVLYDVSHQCRLQYGAYSAFCEDMDNVCHTLWCSVGT-----TCHSKLDAAVDGT 514
Query: 435 ACSLEDRPPLTEPCVHEDC-PLLSDQAWHV-GTWGLCSKSCSSGTRRRQVICAIGPPSHC 492
C E++ L+ CV P D W W +CS+SC G + + C P +
Sbjct: 515 RCG-ENKWCLSGECVPVGFRPEAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYK 573
Query: 493 GSLQHSKPVDVEPCNTQPCHLPQEVPSMQDV 523
G + CN Q C P PS + V
Sbjct: 574 GRYCVGERKRFRLCNLQAC--PAGRPSFRHV 602
Score = 33.9 bits (76), Expect = 1.00
Identities = 29/88 (32%), Positives = 35/88 (39%), Gaps = 20/88 (22%)
Query: 9 LLLAPAPG----SSAPKVRRQSDT-----W--GPWSQWSPCSRTCGGGVSFRERPCYSQR 57
L+ P PG + P R +T W GPW Q CS CGGGV R C + +
Sbjct: 1544 LVTCPEPGLCEEALRPNTTRPCNTHPCTQWVVGPWGQ---CSGPCGGGVQRRLVKCVNTQ 1600
Query: 58 ----RDGGSSCVGPA--RSHRSCRTESC 79
+ C A S R C TE C
Sbjct: 1601 TGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 33.1 bits (74), Expect = 1.7
Identities = 24/74 (32%), Positives = 29/74 (39%), Gaps = 4/74 (5%)
Query: 6 LVPLLLAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCV 65
L P L P + VR G WS+ CS TCG G +R C S RD +
Sbjct: 1394 LAPSLAEAGPPADPLVVRNAGWQAGNWSE---CSTTCGLGAVWRPVRC-SSGRDEDCAPA 1449
Query: 66 GPARSHRSCRTESC 79
G + R C C
Sbjct: 1450 GRPQPARRCHLRPC 1463
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 300 bits (767), Expect = 7e-81
Identities = 182/521 (34%), Positives = 243/521 (46%), Gaps = 50/521 (9%)
Query: 17 SSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-GGSSCVGPARSHRSCR 75
S P W PW WS CSRTCG G FR+R C + GG+ C G + H C
Sbjct: 534 SKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCE 593
Query: 76 TESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNK-CELNCIPKGENFYYKHREA 134
CP G FR +QC D ++ L +K CEL C P G+ +
Sbjct: 594 NLPCPKGLPSFRDQQCQAHD--RLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADR 651
Query: 135 VVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDL 194
V+DGTPC P + D+CV G C+ +GCD + S+ +ED+C C GDG TC+ V G F ++
Sbjct: 652 VLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDF-SHAR 710
Query: 195 SRAVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAPERLHARGPTSEPL-VI 253
A+K+ G+ +N W IE A T + Y R E++ A+GPT PL ++
Sbjct: 711 GTALKD-SGKGSINSDWKIELPGEFQIAGTTVRYVRRG----LWEKISAKGPTKLPLHLM 765
Query: 254 ELISQEPNPGVHYEYHLPLRRPSPG-----------FSWSHGSWSDCSAECGGGHQSRLV 302
L+ + + G+HYEY +P+ R + F W+H W CS +CGGG + +V
Sbjct: 766 VLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIV 825
Query: 303 FCT----IDHEAYPDHMCQRQPRPADR-RSCNLHPCPETKRWKAGPWAPCSASCGGGSQS 357
CT D C + RP + R CNLHPC RW AGPW+PCSA+C G Q
Sbjct: 826 SCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPC--QSRWVAGPWSPCSATCEKGFQH 883
Query: 358 RSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC-AAWSPEPWGECSVSCGVGV 416
R V C+ G A C G +P A+Q+C Q C + W W +CS SCG GV
Sbjct: 884 REVTCVYQLQNGTHVATRPLYCPG--PRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGV 941
Query: 417 RKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV-HEDCPLLSDQAWHVGTWGLCSKSCSS 475
KR+V C +G C RP E C + C W G W CS +C
Sbjct: 942 WKRTVACTNSQGK------CDASTRPRAEEACEDYSGC-----YEWKTGDWSTCSSTCGK 990
Query: 476 GTRRRQVICAIGPP----SHCGSLQHSKPVDVEPCNTQPCH 512
G + R V C S C +L SKP C + C+
Sbjct: 991 GLQSRVVQCMHKVTGRHGSECPAL--SKPAPYRQCYQEVCN 1029
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 284 bits (727), Expect = 3e-76
Identities = 180/602 (29%), Positives = 261/602 (43%), Gaps = 130/602 (21%)
Query: 28 TWGPWSQWSPCSRTCGGGVSFRERPCYS-QRRDGGSSCVGPARSHRSCRTESCPDGARDF 86
+WG WS + CSRTCGGG+ R C + ++GG CVG +SC TE C RDF
Sbjct: 590 SWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDF 649
Query: 87 RAEQCAEFDGAEFQGR----RYRWLPYYSA---PNKCELNCIPKGENFYYKHREAVVDGT 139
R EQCA FDG F RW+P YS ++C+L C G YY+ R+ V+DGT
Sbjct: 650 RDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGT 709
Query: 140 PCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDA-------- 191
PC D+CV G CR GCDH L+S + DKC CGGD ++C VAGTF+
Sbjct: 710 PCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFNTVHYGYNTV 769
Query: 192 ----------------------NDLSRAVKNVRGEYYLNGHWTIE-AARALPAASTILHY 228
+D A+ + +GE+ LNG++ + A R + + ++ Y
Sbjct: 770 VRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEY 829
Query: 229 ERGAEGDLAPERLHARGPTSEPLVIELIS--QEPNPGVHYEYHLPLRRPSPGFSW-SHGS 285
+ + A ER+++ + L+++++S + NP V Y +++P+ F W SHG
Sbjct: 830 ---SGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGP 886
Query: 286 WSDCSAECGGGHQSRLVFCT--IDHEAYPDHMCQRQPRP--------------------- 322
W CS C G + +LV CT D D C R P+P
Sbjct: 887 WQACSKPCQGERKRKLV-CTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVASRS 945
Query: 323 -----------------------------ADRRSCNLHPCPETKR----------WKAGP 343
D C+ HP P + W+
Sbjct: 946 ECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSA 1005
Query: 344 WAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAWSPE 403
W CS SC GG+Q R C+++ + +++++C + IQ C+ C W
Sbjct: 1006 WTECSKSCDGGTQRRRAICVNTR----NDVLDDSKCT--HQEKVTIQRCSEFPCPQWKSG 1059
Query: 404 PWGECSVSCGVGVRKRSVTCR-GERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWH 462
W EC V+CG G + R V C+ GE L+ C E +P + C +C +W
Sbjct: 1060 DWSECLVTCGKGHKHRQVWCQFGE--DRLNDRMCDPETKPTSMQTCQQPEC-----ASWQ 1112
Query: 463 VGTWGLCSKSCSSGTRRRQVICAIG------PPSHCGSLQHSKPVDVEPCNTQPCHLPQE 516
G WG CS +C G + R V C IG + C + ++P D + C CH P
Sbjct: 1113 AGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAA--TRPTDTQDCELPSCHPPPA 1170
Query: 517 VP 518
P
Sbjct: 1171 AP 1172
Score = 178 bits (451), Expect = 3e-44
Identities = 86/235 (36%), Positives = 121/235 (51%), Gaps = 12/235 (5%)
Query: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDH-EAYPDHMCQRQPRPADRRSCNLHPCPETKRW 339
W++G+W +C+ CGGG ++RLV C + E +PD C+ +P DR CN H CP W
Sbjct: 1386 WAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAW 1445
Query: 340 KAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAA 399
GPW+ CS SCG G + R+VYC++ DG+ + E C L KP + C RC
Sbjct: 1446 STGPWSSCSVSCGRGHKQRNVYCMAKDGSHL----ESDYCKHL-AKPHGHRKCRGGRCPK 1500
Query: 400 WSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQ 459
W W +CSVSCG GV++R V C+ + C+ RP C CPL +
Sbjct: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYT-- 1558
Query: 460 AWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQ---HSKPVDVEPCNTQPC 511
W W C+K+C G+R R+V+C + + +PVD E C+ QPC
Sbjct: 1559 -WRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Score = 147 bits (372), Expect = 5e-35
Identities = 138/539 (25%), Positives = 199/539 (36%), Gaps = 101/539 (18%)
Query: 13 PAPGSSAPKVRRQSDTWG-PWSQWSPCSRTCGGGVSFRERPCYSQRRD--GGSSCVGPAR 69
P P S+ K + +T G +S W+ CS++C GG R C + R D S C +
Sbjct: 984 PKP-SNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEK 1042
Query: 70 -SHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYR--WLPYYSA---PNKCELNCIPK 123
+ + C CP +E C G +G ++R W + C+ P
Sbjct: 1043 VTIQRCSEFPCPQWKSGDWSE-CLVTCG---KGHKHRQVWCQFGEDRLNDRMCDPETKPT 1098
Query: 124 GENFYYKHREAVVDGTP-------CEPG---KRDVCVDGSCRVVGCDHELDSSKQEDKCL 173
+ A P C G + C+ G+ V D++ +++ +
Sbjct: 1099 SMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQ 1158
Query: 174 RCGGDGTTCYPVAGTFDANDLSRAVKNVRGEYYLNGHWTIEAARALPAASTILHYE--RG 231
C + +C+P A + R+ + + G WT A T + Y R
Sbjct: 1159 DC--ELPSCHPPPA---APETRRSTYSAPRTQWRFGSWT--PCSATCGKGTRMRYVSCRD 1211
Query: 232 AEGDLAPERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSA 291
G +A E A P P+ E S +P W WS CS
Sbjct: 1212 ENGSVADESACATLP--RPVAKEECSV-----------------TPCGQWKALDWSSCSV 1252
Query: 292 ECGGGHQSRLVFCTIDHEAYPDHM-----CQRQPRPADRRSCNLHPCPET---------- 336
CG G +R V C Y DH+ C + P + C++ PCP+
Sbjct: 1253 TCGQGRATRQVMCV----NYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHP 1308
Query: 337 ---------------------KRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVE 375
+W+ GPW CS++C GGSQ R V C +G + VE
Sbjct: 1309 FQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVE 1368
Query: 376 EAECAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAA 435
KP +AC C W+ WGEC+ CG G+R R V C+ G +
Sbjct: 1369 RI-------KPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLS 1421
Query: 436 CSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGS 494
C + D+PP E C CP D AW G W CS SC G ++R V C SH S
Sbjct: 1422 CEILDKPPDREQCNTHACP--HDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLES 1478
Score = 141 bits (356), Expect = 3e-33
Identities = 155/602 (25%), Positives = 223/602 (37%), Gaps = 142/602 (23%)
Query: 281 WSHGSWSDCSAECGGGHQSRLVFCT-IDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRW 339
W + +W++CS C GG Q R C ++ D C Q + +R C+ PCP+ W
Sbjct: 1001 WRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQR-CSEFPCPQ---W 1056
Query: 340 KAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAA 399
K+G W+ C +CG G + R V+C + + + + + E KP ++Q C CA+
Sbjct: 1057 KSGDWSECLVTCGKGHKHRQVWCQFGEDR-LNDRMCDPET-----KPTSMQTCQQPECAS 1110
Query: 400 WSPEPWGECSVSCGVGVRKRSVTC-RGERGSLLHTAACSLEDRPPLTEPCVHEDC--PLL 456
W PWG+CSV+CG G + R+V C G S++ C+ RP T+ C C P
Sbjct: 1111 WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPA 1170
Query: 457 SDQA-----------WHVGTWGLCSKSCSSGTRRRQVIC-----AIGPPSHCGSLQHSKP 500
+ + W G+W CS +C GTR R V C ++ S C +L +P
Sbjct: 1171 APETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATL--PRP 1228
Query: 501 VDVEPCNTQPCHLPQEVPSMQDVHTPASNPWMPLGPQESPASDSRGQWWAAQEHPSAR-G 559
V E C+ PC W L S S + GQ A ++
Sbjct: 1229 VAKEECSVTPC-----------------GQWKAL--DWSSCSVTCGQGRATRQVMCVNYS 1269
Query: 560 DHRGERGD------PRGDQGTHLSAL---GPAPSLQQPPYQQP---LRSGS-------GP 600
DH +R + P DQ +S P L Q P+Q RS S G
Sbjct: 1270 DHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGG 1329
Query: 601 HDCRHSPHGCC-----------------PDGHTAS-----LGPQWQ-GCPGAPCQQSRYG 637
+ R P G C +G+TA+ + P Q C PC Q YG
Sbjct: 1330 NQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYG 1389
Query: 638 CCPDRVSVAEGPHHAGCTKSYGGDSTGGMPRSRAVASTVHNTHQPQAQ---QNEPSECRG 694
+ CTK G GG+ V + P ++P +
Sbjct: 1390 ------------NWGECTKLCG----GGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQ 1433
Query: 695 SQFGCCYDNVATAAGP-------LGEG-------CVGQP-SHA---YPVRCLLPSAH--- 733
C + A + GP G G C+ + SH Y P H
Sbjct: 1434 CNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKC 1493
Query: 734 --GSCADWAARWYFVASV--GQCNRFWYGGCHGNANNFASEQEC----MSSCQGSLHGPR 785
G C W A + SV G+ + + GC + A E EC + GPR
Sbjct: 1494 RGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPR 1553
Query: 786 RP 787
P
Sbjct: 1554 CP 1555
Score = 139 bits (351), Expect = 1e-32
Identities = 90/249 (36%), Positives = 117/249 (46%), Gaps = 26/249 (10%)
Query: 281 WSHGSWSDCSAECGGGHQSRLVFCTID-HEAYPDHMCQRQPRPADRRSCNLHPCPETKRW 339
W G+WS CS CG G Q R V C I H+ + C RP R C CP W
Sbjct: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCP-LYTW 1559
Query: 340 KAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCA- 398
+A W C+ +CG GS+ R V C+ + + V A C + +P ++C+LQ C
Sbjct: 1560 RAEEWQECTKTCGEGSRYRKVVCVDDN----KNEVHGARC-DVSKRPVDRESCSLQPCEY 1614
Query: 399 AWSPEPWGECSVSCGVGVRKRSVTCR----GERG---SLLHTAACSLEDRPPLTEPCVHE 451
W W ECSV+CG G ++R V+C G+ S T C +PP PC
Sbjct: 1615 VWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCP-GTQPPSVHPCYLR 1673
Query: 452 DCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIG--PPSHCGSLQHS--KPVDVEPC- 506
DCP+ + W VG WG CS SC G +R V C PSH L H+ KP + + C
Sbjct: 1674 DCPVSA--TWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSH---LCHTDLKPEERKTCR 1728
Query: 507 NTQPCHLPQ 515
N C LPQ
Sbjct: 1729 NVYNCELPQ 1737
Score = 106 bits (265), Expect = 1e-22
Identities = 65/196 (33%), Positives = 85/196 (43%), Gaps = 10/196 (5%)
Query: 259 EPNPGVHYEYHLPLRRPS-PGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHE-AYPDHMC 316
E NP E + P P ++W W +C+ CG G + R V C D++ C
Sbjct: 1536 ECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARC 1595
Query: 317 QRQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEE 376
RP DR SC+L PC W G W+ CS +CG G + R V C
Sbjct: 1596 DVSKRPVDRESCSLQPCEYV--WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSY 1653
Query: 377 AECAGLPG-KPPAIQACNLQRC---AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLH 432
PG +PP++ C L+ C A W WG CSVSCGVGV +RSV C H
Sbjct: 1654 QTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSH 1713
Query: 433 TAACSLEDRPPLTEPC 448
C + +P + C
Sbjct: 1714 --LCHTDLKPEERKTC 1727
Score = 53.1 bits (126), Expect = 2e-06
Identities = 77/336 (22%), Positives = 124/336 (36%), Gaps = 81/336 (24%)
Query: 32 WSQ--WSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARSHRS---CRTESCPDGARDF 86
WS WS CS +CG G ++R Y +DG SH C+ + P G R
Sbjct: 1445 WSTGPWSSCSVSCGRG--HKQRNVYCMAKDG---------SHLESDYCKHLAKPHGHRKC 1493
Query: 87 RAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKH------REAVVDGTP 140
R +C ++ A ++C ++C G +H + T
Sbjct: 1494 RGGRCPKWKA--------------GAWSQCSVSC---GRGVQQRHVGCQIGTHKIARETE 1536
Query: 141 CEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFD-ANDLSRAVK 199
C P R + C+ C +++ +C + G+G+ V D N++ A
Sbjct: 1537 CNPYTRPES-ERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARC 1595
Query: 200 NVRG-------------EY-YLNGHWTIEAA-------RALPAASTILHYERGAEGDLAP 238
+V EY ++ G W+ + + L + S I G E
Sbjct: 1596 DVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIY---TGKENYEYS 1652
Query: 239 ERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQ 298
+ P ++P P VH Y LR +W G+W CS CG G
Sbjct: 1653 YQTTINCPGTQP-----------PSVHPCY---LRDCPVSATWRVGNWGSCSVSCGVGVM 1698
Query: 299 SRLVFCTIDHEAYPDHMCQRQPRPADRRSC-NLHPC 333
R V C + +E P H+C +P +R++C N++ C
Sbjct: 1699 QRSVQC-LTNEDQPSHLCHTDLKPEERKTCRNVYNC 1733
Score = 38.5 bits (88), Expect = 0.041
Identities = 28/85 (32%), Positives = 35/85 (41%), Gaps = 7/85 (8%)
Query: 259 EPNPGVH--YEYHLPLRRPSPGFSWSHGSWSD---CSAECGGGHQSRLVFCTIDHEAYPD 313
E PG H Y + +P P S GSWS CS CGGG ++ + C
Sbjct: 565 ECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGG 624
Query: 314 HMCQRQPRPADRRSCNLHPCPETKR 338
C R +SCN PC + KR
Sbjct: 625 KYCVG--RRMKFKSCNTEPCLKQKR 647
Score = 34.7 bits (78), Expect = 0.59
Identities = 19/68 (27%), Positives = 34/68 (50%), Gaps = 6/68 (8%)
Query: 448 CVHEDCPL-LSDQAWHVGTW---GLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDV 503
CV ++ + ++D +W G+W G CS++C G + C P + G + +
Sbjct: 577 CVPKEMDVPVTDGSW--GSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKF 634
Query: 504 EPCNTQPC 511
+ CNT+PC
Sbjct: 635 KSCNTEPC 642
Score = 30.8 bits (68), Expect = 8.5
Identities = 37/154 (24%), Positives = 51/154 (33%), Gaps = 19/154 (12%)
Query: 15 PGSSAPKVR----RQSDTWGPW--SQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPA 68
PG+ P V R W W CS +CG GV R C + C
Sbjct: 1660 PGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDL 1719
Query: 69 R--SHRSCRTE---SCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSA------PNKCE 117
+ ++CR P ++ + + A DG F R + L + A P +
Sbjct: 1720 KPEERKTCRNVYNCELPQNCKEVKRLKGASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYV 1779
Query: 118 LNCIPKGENF--YYKHREAVVDGTPCEPGKRDVC 149
ENF Y HR P +RD C
Sbjct: 1780 TLVHGDSENFSEVYGHRLHNPTECPYNGSRRDDC 1813
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 281 bits (720), Expect = 2e-75
Identities = 181/536 (33%), Positives = 235/536 (43%), Gaps = 81/536 (15%)
Query: 30 GPWSQWSPCSRTCGGGVSFRERPCY---SQRRDGGSSCVGPARSHRSCRTESCPDGARDF 86
G WS WSPCSRTC G+S RER C S+ RD C GP + +R C CP G F
Sbjct: 637 GEWSLWSPCSRTCSAGISSRERKCPGLDSEARD----CNGPRKQYRICENPPCPAGLPGF 692
Query: 87 RAEQCAEFDGAEFQGRRY-RWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPGK 145
R QC + + +W C L C P G+ E V+DGT C
Sbjct: 693 RDWQCQAYSVRTSSPKHILQWQAVLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQG 752
Query: 146 RDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDAN------------D 193
D+C +G C+ VGCD L S +ED C C G+G +C + G F+
Sbjct: 753 LDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPA 812
Query: 194 LSRAVKNVR-------------GEYYLNGHWTIEAARALPAASTILHYERGAEGDLAPER 240
+R +K V G+ +N W IE + A A T +HY R E+
Sbjct: 813 GARRIKVVEEKPAHSYLALRDAGKQSINSDWKIEHSGAFNLAGTTVHYVRRG----LWEK 868
Query: 241 LHARGPTSEPL-VIELISQEPNPGVHYEYHLP---------LRRPSPGFSWSHGSWSDCS 290
+ A+GPT+ PL ++ L+ Q+ N G+HYEY +P + P P F W+H SW DC
Sbjct: 869 ISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWEDCD 928
Query: 291 AECGGGHQSRLVFCT---------IDHEAYPDHMCQRQPRPADR-RSCNLHPCPETKRWK 340
A CGGG + V CT +D+E C+ +P + R CN PC RW
Sbjct: 929 ATCGGGERKTTVSCTKIMSKNISIVDNE-----KCKYLTKPEPQIRKCNEQPC--QTRWM 981
Query: 341 AGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC-AA 399
W PCS +CG G QSR V C G E +C G KP + Q C Q C
Sbjct: 982 MTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIG--PKPASAQRCEGQDCMTV 1039
Query: 400 WSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV-HEDCPLLSD 458
W W ECSV CG G+R R+V C R C L RP E C + C
Sbjct: 1040 WEAGVWSECSVKCGKGIRHRTVRCTNPR------KKCVLSTRPREAEDCEDYSKC----- 1088
Query: 459 QAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGS--LQHSKPVDVEPCNTQPCH 512
W +G W CS +C G + R + C G+ KP PC+ QPC+
Sbjct: 1089 YVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCN 1144
Score = 49.3 bits (116), Expect = 2e-05
Identities = 22/57 (38%), Positives = 28/57 (49%)
Query: 279 FSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPE 335
+ W G WS CS CG G QSR++ C + C +PA R C+L PC E
Sbjct: 1089 YVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNE 1145
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 273 bits (697), Expect = 1e-72
Identities = 165/466 (35%), Positives = 232/466 (49%), Gaps = 53/466 (11%)
Query: 29 WGPWSQWSPCSRTCGGGVSFRERPCYS-QRRDGGSSCVGPARSHRSCRTESCPDGARDFR 87
WG WS WS CSRTCG GV ER C + + + GG C G + +R C C A FR
Sbjct: 545 WGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFR 604
Query: 88 AEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPG--K 145
QC+EFD ++ Y W P ++ + CEL C P F K +AV+DGTPC G
Sbjct: 605 QMQCSEFDTVPYKNELYHWFPIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNS 664
Query: 146 RDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPV---------AGTFDANDLSR 196
R+VC++G C++VGCD+E+DS+ ED+C C GDG++C V +G D + +
Sbjct: 665 RNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPK 724
Query: 197 AVKNVR------------------GEYYLNGHWTIEAARALPAASTILHYERGAEGDLAP 238
+++R +YYLNG + I+ A T+ Y+R +GDL
Sbjct: 725 GARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDR--KGDL-- 780
Query: 239 ERLHARGPTSEPLVIELISQEPNPGVHYEY-----HLPLRRPSPGFSWSHGSWSDCSAEC 293
E+L A GPT+E + I+L+ Q NPG+ YEY L + W +G W++CS C
Sbjct: 781 EKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTC 840
Query: 294 GGGHQSRLVFCTIDHEA-YPDHMCQRQPRPADR-RSCNLHPCPETKRWKAGPWAPCSASC 351
G G + + C C + +P R + C+ CP RW AG W CSA+C
Sbjct: 841 GTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACP--PRWWAGEWEACSATC 898
Query: 352 G-GGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQ-RCAA-WSPEPWGEC 408
G G + R+V CI + ++A+ +C L KP + +CN C + W+ W EC
Sbjct: 899 GPHGEKKRTVLCIQT-MVSDEQALPPTDCQHLL-KPKTLLSCNRDILCPSDWTVGNWSEC 956
Query: 409 SVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCP 454
SVSCG GVR RSVTC H C + +P C + CP
Sbjct: 957 SVSCGGGVRIRSVTCAKN-----HDEPCDVTRKPNSRALCGLQQCP 997
Score = 137 bits (344), Expect = 8e-32
Identities = 80/237 (33%), Positives = 101/237 (42%), Gaps = 28/237 (11%)
Query: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRWK 340
W G+WS+CS CG G R V C+ D C RP + C+L PC WK
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQM----DSDCAAIQRPDPAKRCHLRPCAG---WK 1369
Query: 341 AGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAW 400
G W+ CS +C GG + R + C+ S AG+P PP +CN + C AW
Sbjct: 1370 VGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIP--PPLSMSCNPEPCEAW 1427
Query: 401 SPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQA 460
EPW +CS SCG GV++R V C G C RP T C C
Sbjct: 1428 QVEPWSQCSRSCGGGVQERGVFCPG--------GLCDWTKRPTSTMSCNEHLC-----CH 1474
Query: 461 WHVGTWGLCSKSCSSGTRRRQVICA------IGPPSHCGSLQHSKPVDVEPCNTQPC 511
W G W LCS SC G ++R V C C +P + + CN Q C
Sbjct: 1475 WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
Score = 103 bits (257), Expect = 1e-21
Identities = 68/208 (32%), Positives = 91/208 (43%), Gaps = 30/208 (14%)
Query: 258 QEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHM 315
Q P+P HL RP G W G+WS CS C GG + R + C + DH
Sbjct: 1352 QRPDPAKRC--HL---RPCAG--WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFH 1404
Query: 316 CQ--RQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEA 373
CQ P SCN PC + W+ PW+ CS SCGGG Q R V+C G+ +
Sbjct: 1405 CQFLAGIPPPLSMSCNPEPC---EAWQVEPWSQCSRSCGGGVQERGVFC----PGGLCDW 1457
Query: 374 VEEAECAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTC---RGERGSL 430
+ +P + +CN C W+ W CS SCG G +KR+V C G +
Sbjct: 1458 TK---------RPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTED 1508
Query: 431 LHTAACSLEDRPPLTEPCVHEDCPLLSD 458
C + RPP + C + C +D
Sbjct: 1509 QDQCLCDHKPRPPEFKKCNQQACKKSAD 1536
Score = 67.4 bits (163), Expect = 8e-11
Identities = 43/138 (31%), Positives = 54/138 (39%), Gaps = 16/138 (11%)
Query: 390 QACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV 449
Q N A W W ECS +CG+G R V C + S C+ RP + C
Sbjct: 1307 QLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMDS-----DCAAIQRPDPAKRCH 1361
Query: 450 HEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIG------PPSHCGSLQHSKPVDV 503
C W VG W CS++CS G + R++ C P HC L P
Sbjct: 1362 LRPC-----AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLS 1416
Query: 504 EPCNTQPCHLPQEVPSMQ 521
CN +PC Q P Q
Sbjct: 1417 MSCNPEPCEAWQVEPWSQ 1434
Score = 53.1 bits (126), Expect = 2e-06
Identities = 23/58 (39%), Positives = 31/58 (53%), Gaps = 4/58 (6%)
Query: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKR 338
W+ G+WS+CS CGGG + R V C +H D C +P R C L CP ++R
Sbjct: 948 WTVGNWSECSVSCGGGVRIRSVTCAKNH----DEPCDVTRKPNSRALCGLQQCPSSRR 1001
Score = 36.2 bits (82), Expect = 0.20
Identities = 21/58 (36%), Positives = 25/58 (43%), Gaps = 4/58 (6%)
Query: 277 PGFSWSHGS-WSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPC 333
PG W S WS CS CG G QS C + C + + R CN+HPC
Sbjct: 542 PG-GWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERK--RYRLCNVHPC 596
Score = 33.9 bits (76), Expect = 1.00
Identities = 30/85 (35%), Positives = 35/85 (41%), Gaps = 11/85 (12%)
Query: 35 WSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPAR--SHRSCRTESCPDGARDFRAEQCA 92
WS CSR+CGGGV R C G C R S SC C A + C+
Sbjct: 1432 WSQCSRSCGGGVQERGVFC------PGGLCDWTKRPTSTMSCNEHLCCHWATG-NWDLCS 1484
Query: 93 EFDGAEFQGRRYRWLPYYSAPNKCE 117
G FQ R + +P S NK E
Sbjct: 1485 TSCGGGFQKRTVQCVP--SEGNKTE 1507
Score = 32.0 bits (71), Expect = 3.8
Identities = 12/23 (52%), Positives = 12/23 (52%)
Query: 35 WSPCSRTCGGGVSFRERPCYSQR 57
WS CSR C GG RE C R
Sbjct: 1373 WSKCSRNCSGGFKIREIQCVDSR 1395
Score = 30.8 bits (68), Expect = 8.5
Identities = 14/58 (24%), Positives = 24/58 (41%), Gaps = 2/58 (3%)
Query: 466 WGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQEVPSMQDV 523
W CS++C +G + + +C P G + CN PC E P+ + +
Sbjct: 551 WSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCR--SEAPTFRQM 606
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 269 bits (687), Expect = 1e-71
Identities = 169/544 (31%), Positives = 249/544 (45%), Gaps = 70/544 (12%)
Query: 21 KVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYS-QRRDGGSSCVGPARSHRSCRTESC 79
+ R + WGPW +S CSRTCGGG+ R C + R+GG+ CVG RSC T+SC
Sbjct: 551 ETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSC 610
Query: 80 PDGARDFRAEQCAEFDGAEFQ----GRRYRWLPYYSA---PNKCELNCIPKGENFYYKHR 132
P G +DFR +QC++F+G RWLP YS ++C+L C G N++Y +
Sbjct: 611 PKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLK 670
Query: 133 EAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDA- 191
+ V DGTPC D+CV G C GCDH L+SS + DKC CGGD ++C + G F++
Sbjct: 671 DMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSS 730
Query: 192 ----------------------------NDLSRAVKNVRGEYYLNGHWTIEAARA---LP 220
+D A+ + G + NG++ + ++ +
Sbjct: 731 HYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQ 790
Query: 221 AASTILHYERGAEGDLAPERLHARGPTSEPLVIEL--ISQEPNPGVHYEYHLPLRRPSPG 278
T++ Y + + A ER+++ + L++++ + NP VHY +++PL S
Sbjct: 791 GTRTVIEY---SGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDM 847
Query: 279 FSWS-HGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQRQPRPA-DRRSCNLHPCP 334
F+W +G W C+ C G Q R + C DH D C P P+ +SCN C
Sbjct: 848 FTWDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNT-DC- 904
Query: 335 ETKRWKAGPWAPCSASCGGGSQSRSVYCIS-SDGAGIQEAVEEAECAGLPGKPPAIQACN 393
RW + CS+ CG G ++ ++C+ S G V++ C G KPP + C+
Sbjct: 905 -ELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYC-GDQLKPPTQELCH 962
Query: 394 LQRC--AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHE 451
C W W +CS SCG G R R C G L C R E
Sbjct: 963 -GNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSR------VTRE 1015
Query: 452 DCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIG----PPSHCGSLQHSKPVDVEPCN 507
+C S +W W C +C GT++RQV C + C S +KP + PC
Sbjct: 1016 NCNEFSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNS--STKPESLSPCE 1073
Query: 508 TQPC 511
C
Sbjct: 1074 LHTC 1077
Score = 160 bits (404), Expect = 9e-39
Identities = 143/543 (26%), Positives = 208/543 (38%), Gaps = 103/543 (18%)
Query: 32 WSQWSPCSRTCGGGVSFRERPCYSQ--RRDGGSSCVGPARSHR-SCRTESCPDGARDFRA 88
+S+WS CSR+CGGG RE C + R + C +R R +C SCP A +
Sbjct: 972 YSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCPSWAASEWS 1031
Query: 89 EQCAEFDGAEFQGRRYRWLPY---YSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPGK 145
E C G + R+ W + + C + P+ + H A P P
Sbjct: 1032 E-CLVTCGKGTKQRQV-WCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGPWGPCT 1089
Query: 146 RDVCVDGSCRVVGCDHELDSSKQED-KCLRCG--GDGTTCYPVAGTFDANDLSRAVKNV- 201
R V C +EL S+ ED +C D +C +F + + + V
Sbjct: 1090 TTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVL 1149
Query: 202 --RGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAPERLHARGPTSEPLVIELISQE 259
+ + +G WT P + + RG + R ++ I+ E
Sbjct: 1150 IKKMAQWRHGSWT-------PCSVSC---GRGTQARYVSCRD----------ALDRIADE 1189
Query: 260 PNPGVHYEYHLPLRRPS-------PGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYP 312
Y HLP RP+ P W G WS CSA CG G +R V C H+
Sbjct: 1190 S-----YCAHLP--RPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPID 1242
Query: 313 DHMCQRQPRPADRRSCNLHPCPET------------------------------------ 336
++ C + RP + C+L CP
Sbjct: 1243 ENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPS 1302
Query: 337 ---KRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACN 393
+W+ GPW CS+SC GG Q R+V C +G + A KPP +Q C
Sbjct: 1303 VRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENG-------QSASYCDAASKPPELQQCG 1355
Query: 394 LQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDC 453
C W+ WGECS +CG G++ R V C+ G +L C + ++PP C C
Sbjct: 1356 PGPCPQWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHAC 1415
Query: 454 PLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIG-----PPSHCGSLQHSKPVDVEPCNT 508
P +D +WH W CS SC G + R+V C ++C +Q KP + C +
Sbjct: 1416 P--ADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQ--KPPTHKACRS 1471
Query: 509 QPC 511
C
Sbjct: 1472 VRC 1474
Score = 146 bits (369), Expect = 1e-34
Identities = 123/491 (25%), Positives = 191/491 (38%), Gaps = 75/491 (15%)
Query: 35 WSPCSRTCGGGVSFRERPCYS--QRRDGGSSCVGPARSHRSCRTESCPDGARDFRAEQCA 92
W+PCS +CG G R C R S C A R C +++A +
Sbjct: 1161 WTPCSVSCGRGTQARYVSCRDALDRIADESYC---AHLPRPAEIWDCFTPCGEWQAGDWS 1217
Query: 93 EFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPGKRDVCVDG 152
+ G+ R ++ C+ N++ +D C+P R + ++
Sbjct: 1218 PCSASCGHGKTTR-----------QVLCM----NYHQP-----IDENYCDPEVRPL-MEQ 1256
Query: 153 SCRVVGC----DHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDLSRAVKNVRGEYYLN 208
C + C H S Q L +T P+ + N+ +VRG +
Sbjct: 1257 ECSLAACPPAHSHFPSSPVQPSYYL------STNLPLTQKLEDNENQVVHPSVRGNQWRT 1310
Query: 209 GHW---TIEAARALPAASTILHYERGAEGDLAPERLHARGPTSEPLVIELISQEPNPGVH 265
G W + + L + + E G S+P + Q+ PG
Sbjct: 1311 GPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDA-------ASKPPEL----QQCGPG-- 1357
Query: 266 YEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDH-EAYPDHMCQRQPRPAD 324
P P W++G+W +CS CGGG +SRLV C + + DH C+ +P
Sbjct: 1358 ---------PCP--QWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPS 1406
Query: 325 RRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPG 384
C++H CP W PW CSASCG G + R V+CI Q +E+ C+ +
Sbjct: 1407 VIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQ----FQRKLEDTNCSQVQ- 1461
Query: 385 KPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPL 444
KPP +AC RC +W W ECSV+CG GV++R V CR + + C RP
Sbjct: 1462 KPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCS 1521
Query: 445 TEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSK---PV 501
C +DC + + G CS SC +++ C + ++ +
Sbjct: 1522 QRRCWSQDC--VQHKGMERGRLN-CSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISL 1578
Query: 502 DVEPCNTQPCH 512
+ C PC+
Sbjct: 1579 TSKNCRNPPCN 1589
Score = 134 bits (337), Expect = 5e-31
Identities = 105/387 (27%), Positives = 141/387 (36%), Gaps = 74/387 (19%)
Query: 280 SWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRW 339
SW+ WS+C CG G + R V+C ++ + D C +P C LH C W
Sbjct: 1024 SWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCAS---W 1080
Query: 340 KAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC-- 397
+ GPW PC+ +CG G Q R V C++ + + +E+ EC +P Q+C L C
Sbjct: 1081 QVGPWGPCTTTCGHGYQMRDVKCVNELASAV---LEDTECHE-ASRPSDRQSCVLTPCSF 1136
Query: 398 -----------------AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLED 440
A W W CSVSCG G + R V+CR + + C+
Sbjct: 1137 ISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLP 1196
Query: 441 RPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKP 500
RP C W G W CS SC G RQV+C + + +P
Sbjct: 1197 RPAEIWDC------FTPCGEWQAGDWSPCSASCGHGKTTRQVLC----------MNYHQP 1240
Query: 501 VD-------VEPCNTQPCHLPQEVPSMQDVHTPASNPWMPLG---PQESPASDSRGQWWA 550
+D V P Q C L P+ + P L P D+ Q
Sbjct: 1241 IDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQ--- 1297
Query: 551 AQEHPSARGDHRGERGDPRGDQGTHLSALGPAPSLQQPPYQQPLRSGSGPHDCRHSPHGC 610
HPS RG+ R P G + S LQ +G C
Sbjct: 1298 -VVHPSVRGNQ--WRTGPWGSCSSSCSG-----GLQHRAVVCQDENGQSASYC------- 1342
Query: 611 CPDGHTASLGPQWQGCPGAPCQQSRYG 637
AS P+ Q C PC Q YG
Sbjct: 1343 ----DAASKPPELQQCGPGPCPQWNYG 1365
Score = 132 bits (331), Expect = 3e-30
Identities = 80/252 (31%), Positives = 110/252 (43%), Gaps = 34/252 (13%)
Query: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDH-EAYPDHMCQRQPRPADRRSCNLHPCPETKRW 339
W + WS CS CGGG +SR +C + D+ CQ R R +CN CP W
Sbjct: 970 WHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSR-VTRENCNEFSCPS---W 1025
Query: 340 KAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAA 399
A W+ C +CG G++ R V+C + + + + C KP ++ C L CA+
Sbjct: 1026 AASEWSECLVTCGKGTKQRQVWCQLN-----VDHLSDGFCNSST-KPESLSPCELHTCAS 1079
Query: 400 WSPEPWGECSVSCGVGVRKRSVTCRGERGS-LLHTAACSLEDRPPLTEPCVHEDCPLLSD 458
W PWG C+ +CG G + R V C E S +L C RP + CV C +S
Sbjct: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISK 1139
Query: 459 --------------QAWHVGTWGLCSKSCSSGTRRRQVIC-----AIGPPSHCGSLQHSK 499
W G+W CS SC GT+ R V C I S+C L +
Sbjct: 1140 LETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHL--PR 1197
Query: 500 PVDVEPCNTQPC 511
P ++ C T PC
Sbjct: 1198 PAEIWDCFT-PC 1208
Score = 88.2 bits (217), Expect = 4e-17
Identities = 66/248 (26%), Positives = 94/248 (37%), Gaps = 30/248 (12%)
Query: 280 SWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYP-DHMCQRQPRPADRRSCNLHPCPETKR 338
SW SW++CS CG G Q R V+C + + MC + RP +R C C + K
Sbjct: 1476 SWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKG 1535
Query: 339 WKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCA 398
+ G CS SC + + C + + E V + L K CN
Sbjct: 1536 MERGR-LNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVT 1594
Query: 399 AWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSD 458
A S +C+ +CG R+R C + H + P V+++CP++
Sbjct: 1595 ADS----SQCANNCGFSYRQRITYCTEIPSTKKH--------KLHRLRPIVYQECPVVPS 1642
Query: 459 Q-------------AWHVGTWGLCSKSCSSGTRRRQVICAI--GPPSHCGSLQHSKPVDV 503
W VG W CS +C G +RQV C G S L H KP
Sbjct: 1643 SQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDL-CLNHLKPGAQ 1701
Query: 504 EPCNTQPC 511
+ C C
Sbjct: 1702 KKCYANDC 1709
Score = 51.2 bits (121), Expect = 6e-06
Identities = 33/125 (26%), Positives = 50/125 (40%), Gaps = 19/125 (15%)
Query: 287 SDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHP----------CPET 336
S C+ CG ++ R+ +CT + + H R RP + C + P C
Sbjct: 1598 SQCANNCGFSYRQRITYCT-EIPSTKKHKLHRL-RPIVYQECPVVPSSQVYQCINSCLHL 1655
Query: 337 KRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQR 396
WK G W+ CS +CG G R V CI+ G + KP A + C
Sbjct: 1656 ATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHL-------KPGAQKKCYAND 1708
Query: 397 CAAWS 401
C +++
Sbjct: 1709 CKSFT 1713
Score = 37.7 bits (86), Expect = 0.069
Identities = 20/55 (36%), Positives = 27/55 (49%), Gaps = 6/55 (10%)
Query: 32 WSQ--WSPCSRTCGGGVSFRERPCYSQ----RRDGGSSCVGPARSHRSCRTESCP 80
W Q W+ CS +CG G +RE C Q D S V +H++CR+ CP
Sbjct: 1421 WHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCP 1475
Score = 32.3 bits (72), Expect = 2.9
Identities = 18/63 (28%), Positives = 24/63 (38%), Gaps = 5/63 (7%)
Query: 20 PKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPAR--SHRSCRTE 77
P VR GPW CS +C GG+ R C + S C ++ + C
Sbjct: 1301 PSVRGNQWRTGPWGS---CSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPG 1357
Query: 78 SCP 80
CP
Sbjct: 1358 PCP 1360
Score = 32.0 bits (71), Expect = 3.8
Identities = 24/79 (30%), Positives = 31/79 (39%), Gaps = 7/79 (8%)
Query: 262 PGVHYEYHLPLR-----RPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMC 316
PG+H + L + RP G +S CS CGGG +S C + C
Sbjct: 536 PGMHCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYC 595
Query: 317 QRQPRPADRRSCNLHPCPE 335
R RSCN CP+
Sbjct: 596 --VGRRMKFRSCNTDSCPK 612
Score = 31.2 bits (69), Expect = 6.5
Identities = 17/62 (27%), Positives = 25/62 (40%), Gaps = 5/62 (8%)
Query: 30 GPWS--QWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGP---ARSHRSCRTESCPDGAR 84
G W WSPCS +CG G + R+ C + + + P + C +CP
Sbjct: 1209 GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAHS 1268
Query: 85 DF 86
F
Sbjct: 1269 HF 1270
Score = 30.8 bits (68), Expect = 8.5
Identities = 24/70 (34%), Positives = 28/70 (40%), Gaps = 25/70 (35%)
Query: 33 SQWSPCSRTCGGGVSFRE--------------------RPCYSQRRDGGSSCV---GPAR 69
+ W+ CS TCG GV R+ RPC SQRR CV G R
Sbjct: 1480 NSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPC-SQRRCWSQDCVQHKGMER 1538
Query: 70 SHRSCRTESC 79
+C T SC
Sbjct: 1539 GRLNCST-SC 1547
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 265 bits (678), Expect = 2e-70
Identities = 182/603 (30%), Positives = 259/603 (42%), Gaps = 102/603 (16%)
Query: 3 LLLLVPLLLAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGS 62
LL L LLL+ S D WGPWS+ CSRTCGGG S+ R C S +
Sbjct: 13 LLFLAFLLLSSRTARSEEDRDGLWDAWGPWSE---CSRTCGGGASYSLRRCLSSK----- 64
Query: 63 SCVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAP-NKCELNCI 121
SC G +R+C CP A DFRA+QC+ + + G+ Y WLP + P N C L C
Sbjct: 65 SCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQ 124
Query: 122 PKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTT 181
KG + V+DGT C D+C+ G C++VGCDH+L S+ +ED C C GDG+T
Sbjct: 125 AKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGST 184
Query: 182 CYPVAGTFDAN-DLSRAVKNVRGEYYLNGHWTI------------------EAARALPAA 222
C V G + + +++ V Y + H + + +L +
Sbjct: 185 CRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSST 244
Query: 223 STILHYERGAEGDLAPER--LHARGPTSEPLVIEL-ISQEPNPGVHYEYHLPLRRPSPGF 279
T L + P++ L GP + ++++ S + V + ++ P+
Sbjct: 245 GTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIH----- 299
Query: 280 SWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQRQP---RPADR-RSCNLHPC 333
W + CSA CGGG+Q C + D C P +P + + CNL PC
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
Query: 334 PET---------------KRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAE 378
P + RW+A PW CS+SCGGG QSR+V C+ D G +VEE +
Sbjct: 360 PASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
Query: 379 CAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSL 438
C P K P Q CN+ C W + W C+V+CG G+R R V C RG +HT CS
Sbjct: 420 CMYTP-KMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSP 476
Query: 439 EDRPPLTEPCV--------HEDCPLLSDQAWH-------------------VGTWGLCSK 471
+ +P + E C+ E P+ + W W C+
Sbjct: 477 KTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTV 536
Query: 472 SCSSGTRRRQVICAI----------GPPSHCGSLQHSKPVDVEPCNTQPC--HLPQEVPS 519
+C GT+ R V C + P C + KP C PC +P+ P
Sbjct: 537 TCGVGTQVRIVRCQVLLSFSQSVADLPIDEC---EGPKPASQRACYAGPCSGEIPEFNPD 593
Query: 520 MQD 522
D
Sbjct: 594 ETD 596
Score = 148 bits (373), Expect = 4e-35
Identities = 150/552 (27%), Positives = 209/552 (37%), Gaps = 75/552 (13%)
Query: 11 LAPAPGSSAPKVRRQSDTWGP---W--SQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCV 65
L P P S K D + P W + W+ CS +CGGG+ R C + G + V
Sbjct: 356 LDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV 415
Query: 66 GPARSH--------RSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCE 117
+ + C CP + A++ + QG RYR +
Sbjct: 416 EEWKCMYTPKMPIAQPCNIFDCPK----WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHT 471
Query: 118 LNCIPKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSS---KQEDKCLR 174
C PK + +E + TPC K + V+ EL+ +E +
Sbjct: 472 GGCSPKTKPHI---KEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIP 528
Query: 175 CGGDGTTCYPVAGTFDANDLSRAVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEG 234
T GT V+ VR + L+ ++ LP EG
Sbjct: 529 EAWSACTVTCGVGT--------QVRIVRCQVLLSFS---QSVADLPIDE--------CEG 569
Query: 235 DL-APERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAEC 293
A +R GP S + E NP L+ + W + ++ CS C
Sbjct: 570 PKPASQRACYAGPCSGEI------PEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESC 623
Query: 294 GGGHQSRLVFCTIDHEAYP--DHMCQRQPRPADR-RSCNLHPCPETKRWKAGPWAPCSAS 350
GGG Q +V C P +++C RP +SCNL PCP RW+ G W+PCS +
Sbjct: 624 GGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPA--RWEIGKWSPCSLT 681
Query: 351 CGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC-AAWSPEPWGECS 409
CG G Q+R V+C + E V A+ KP +QACN C AW P W CS
Sbjct: 682 CGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCS 741
Query: 410 VSCGVGVRKRSVTC--RGERGSLLH--TAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGT 465
+CG GV+KR V C R GS L CS +P + C +DCP W +
Sbjct: 742 RTCGGGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQQACKKDDCP----SEWLLSD 796
Query: 466 WGLCSKSCSSGTRRRQVIC---------AIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQE 516
W CS SC GT+ R IC + + C L S + PC C P
Sbjct: 797 WTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSS--SIRPCMLATCARPGR 854
Query: 517 VPSMQDVHTPAS 528
+ H A+
Sbjct: 855 PSTKHSPHIAAA 866
Score = 127 bits (319), Expect = 7e-29
Identities = 83/243 (34%), Positives = 110/243 (45%), Gaps = 20/243 (8%)
Query: 281 WSHGSWSDCSAECG--GGHQSRLVFCTIDHEAYPDHMCQRQPRPADRR-SCNLHPCPETK 337
WS + CSA CG G Q RL E P H C + RPA + +CN CP
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAH-CAGKVRPAVQPIACNRRDCPS-- 1547
Query: 338 RWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397
RW W+ C+ SCGGG Q+R V C +GI V C + +P QACN Q C
Sbjct: 1548 RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC 1607
Query: 398 AAWSPEPWGECSVSC---GVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCP 454
W+ WG+C+ C + V+ R V C+ G L + CS RP T+ C E C
Sbjct: 1608 VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACS 1667
Query: 455 LLSDQAWHVGTWGLCSKSCSS-GTRRRQVICA-----IGPPSHCGSLQHSKPVDVEPCNT 508
+ W V W LC+ +C + G + R+V C P H S +P + + CN
Sbjct: 1668 V----HWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCS-WGPRPANWQRCNI 1722
Query: 509 QPC 511
PC
Sbjct: 1723 TPC 1725
Score = 77.8 bits (190), Expect = 6e-14
Identities = 59/186 (31%), Positives = 87/186 (46%), Gaps = 22/186 (11%)
Query: 1028 ASPGQRIRMTCRAEGFPPPAIEWQRDGQPVS-SPRHQLQPDGSLVISRVAVEDGGFYTCV 1086
AS + + C A G P P I W R+G+ V S R LQPD SL I D GFYTC
Sbjct: 1192 ASGTLSVLLHCEAIGHPRPTISWARNGEEVQFSDRILLQPDDSLQILAPVEADVGFYTCN 1251
Query: 1087 AFNGQDRDQRWVQLRVLGE--------LTISGLPPTVTVPEGDTARLL--------CVVA 1130
A N D + + + G+ I+ P VTV G T + + C VA
Sbjct: 1252 ATNALGYDSVSIAVTLAGKPLVKTSRMTVINTEKPAVTVDIGSTIKTVQGVNVTINCQVA 1311
Query: 1131 G-ESVNIRWSRNGLPVQADGHRVHQSPDGTLLIYNLRARDEGSYTCSAYQGSQAVSRSTE 1189
G + W RN + + H +H+ G+LL+ N+ + D+G Y+C A ++ ST+
Sbjct: 1312 GVPEAEVTWFRNKSKLGSP-HHLHE---GSLLLTNVSSSDQGLYSCRAANLHGELTESTQ 1367
Query: 1190 VKVVSP 1195
+ ++ P
Sbjct: 1368 LLILDP 1373
Score = 74.3 bits (181), Expect = 7e-13
Identities = 94/354 (26%), Positives = 137/354 (38%), Gaps = 75/354 (21%)
Query: 866 GDAGSPAPPFH---------SSSYRISLAGVEPSLVQA---ALGQL-VRLSCSDDTAPES 912
GDAG + H S++ ++S + V L Q A G L V L C P
Sbjct: 1151 GDAGGGSRRPHRKPTILRKISAAQQLSASEVVTHLGQTVALASGTLSVLLHCEAIGHPRP 1210
Query: 913 QAAWQKDGQPIS-SDRHRLQFDGSL-IIHPLQAEDAGTYSCGSTRP-GRDSQKIQLRIIG 969
+W ++G+ + SDR LQ D SL I+ P++A D G Y+C +T G DS I + + G
Sbjct: 1211 TISWARNGEEVQFSDRILLQPDDSLQILAPVEA-DVGFYTCNATNALGYDSVSIAVTLAG 1269
Query: 970 GDMAVLSEAELSRFPQPRDPAQDFGQAGAAGPLGAIPSSHPQPANRLRLDQNQPRVVDAS 1029
+ S + +P D G +
Sbjct: 1270 KPLVKTSRMTVINTEKPA-VTVDIGS-----------------------------TIKTV 1299
Query: 1030 PGQRIRMTCRAEGFPPPAIEWQRDGQPVSSPRHQLQPDGSLVISRVAVEDGGFYTCVAFN 1089
G + + C+ G P + W R+ + SP H +GSL+++ V+ D G Y+C A N
Sbjct: 1300 QGVNVTINCQVAGVPEAEVTWFRNKSKLGSPHH--LHEGSLLLTNVSSSDQGLYSCRAAN 1357
Query: 1090 GQDRDQRWVQL---------------RVLGELTISGLPPTVTVP--------EGDTARLL 1126
QL R L T LP +T P G++A L
Sbjct: 1358 LHGELTESTQLLILDPPQVPTQLEDIRALLAATGPNLPSVLTSPLGTQLVLDPGNSALLG 1417
Query: 1127 CVVAGESV-NIRWSRNGLP-VQADGHRVHQSPDGTLL-IYNLRARDEGSYTCSA 1177
C + G V NI W G P V A G H G +L + NL +G ++C A
Sbjct: 1418 CPIKGHPVPNITWFHGGQPIVTATGLTHHILAAGQILQVANLSGGSQGEFSCLA 1471
Score = 51.6 bits (122), Expect = 5e-06
Identities = 48/206 (23%), Positives = 83/206 (40%), Gaps = 32/206 (15%)
Query: 890 SLVQAALGQLVRLSCSDDTAPESQAAWQKDGQPISSDRHRLQFDGSLIIHPLQAEDAGTY 949
S ++ G V ++C PE++ W ++ + S H +GSL++ + + D G Y
Sbjct: 1294 STIKTVQGVNVTINCQVAGVPEAEVTWFRNKSKLGSPHHL--HEGSLLLTNVSSSDQGLY 1351
Query: 950 SCGSTRPGRDSQKIQLRIIGGDMAVLSEAELSRFPQPRDPAQDF-GQAGAAGPLGAIPSS 1008
SC + + G++ ++ + PQ +D A GP +PS
Sbjct: 1352 SCRAAN------------LHGELTESTQLLILDPPQVPTQLEDIRALLAATGP--NLPSV 1397
Query: 1009 HPQP-ANRLRLDQNQPRVVDASPGQRIRMTCRAEGFPPPAIEWQRDGQPVSS----PRHQ 1063
P +L LD PG + C +G P P I W GQP+ + H
Sbjct: 1398 LTSPLGTQLVLD----------PGNSALLGCPIKGHPVPNITWFHGGQPIVTATGLTHHI 1447
Query: 1064 LQPDGSLVISRVAVEDGGFYTCVAFN 1089
L L ++ ++ G ++C+A N
Sbjct: 1448 LAAGQILQVANLSGGSQGEFSCLAQN 1473
Score = 40.8 bits (94), Expect = 0.008
Identities = 22/59 (37%), Positives = 29/59 (49%), Gaps = 1/59 (1%)
Query: 1030 PGQRIRMTCRAEGFPPPAIEWQRDGQPVSSPRH-QLQPDGSLVISRVAVEDGGFYTCVA 1087
P + + C A P I W++DGQ + S H + P G L I R+ D G YTC A
Sbjct: 891 PKTAVVLRCPARRVRKPLITWEKDGQHLISSTHVTVAPFGYLKIHRLKPSDAGVYTCSA 949
Score = 40.8 bits (94), Expect = 0.008
Identities = 40/136 (29%), Positives = 62/136 (45%), Gaps = 12/136 (8%)
Query: 900 VRLSCSDDTAPESQAAWQKDGQPISSDRH-RLQFDGSLIIHPLQAEDAGTYSCGSTRPGR 958
V L C + W+KDGQ + S H + G L IH L+ DAG Y+C S P R
Sbjct: 895 VVLRCPARRVRKPLITWEKDGQHLISSTHVTVAPFGYLKIHRLKPSDAGVYTC-SAGPAR 953
Query: 959 DSQKIQLRIIGGDMAVLSEAELSRFPQPRDPAQDF-GQAGAAGPLGAIPSSHPQPANRLR 1017
+ +++IGG+ + ++R PR + G+ G GP A+ + Q
Sbjct: 954 --EHFVIKLIGGNRKL-----VARPLSPRSEEEVLAGRKG--GPKEALQTHKHQNGIFSN 1004
Query: 1018 LDQNQPRVVDASPGQR 1033
+ + R + A+PG R
Sbjct: 1005 GSKAEKRGLAANPGSR 1020
Score = 33.9 bits (76), Expect = 1.00
Identities = 14/33 (42%), Positives = 19/33 (57%)
Query: 33 SQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCV 65
+ WS C+R+CGGGV R C + G S+ V
Sbjct: 1552 TSWSACTRSCGGGVQTRRVTCQKLKASGISTPV 1584
Score = 32.0 bits (71), Expect = 3.8
Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 1/42 (2%)
Query: 1136 IRWSRNGLPVQADGHRVHQSPDGTLLIYNLRARDEGSYTCSA 1177
I W ++G + + H V +P G L I+ L+ D G YTCSA
Sbjct: 909 ITWEKDGQHLISSTH-VTVAPFGYLKIHRLKPSDAGVYTCSA 949
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 261 bits (667), Expect = 3e-69
Identities = 169/585 (28%), Positives = 250/585 (42%), Gaps = 106/585 (18%)
Query: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARSHRSCRTESCPDGARDFRA 88
W W WS CSRTCGGG S+ R C + G +C G +++C CP A DFRA
Sbjct: 78 WDAWGDWSDCSRTCGGGASYSLRRCLT-----GRNCEGQNIRYKTCSNHDCPPDAEDFRA 132
Query: 89 EQCAEFDGAEFQGRRYRWLPYYSAPNK-CELNCIPKGENFYYKHREAVVDGTPCEPGKRD 147
+QC+ ++ ++QG Y WLP Y+ P C L C +G+N + V+DGT C D
Sbjct: 133 QQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDSLD 192
Query: 148 VCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDL------------- 194
+C+ G C+ VGCD +L S+ +ED C C GDG+TC V G ++
Sbjct: 193 MCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREENVIAVPL 252
Query: 195 -SRAVK-NVRGEYYL----------NGHWTIEAARALPAASTILHYERGAEGDLAPERLH 242
SR+V+ V+G +L G + + +T + ++RG+E +
Sbjct: 253 GSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSE----RQTFK 308
Query: 243 ARGPTSEPLVIEL-ISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRL 301
GP + + + + V + ++ P+ W + C+ CGGG+Q
Sbjct: 309 IPGPLMADFIFKTRYTAAKDSVVQFFFYQPI-----SHQWRQTDFFPCTVTCGGGYQLNS 363
Query: 302 VFCTID---HEAYPDHMCQRQP---RPADR-RSCNLHPCPET---------------KRW 339
C +D PDH C P +P + + C++ PCP + RW
Sbjct: 364 AEC-VDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRW 422
Query: 340 KAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAA 399
+ PW CS SCGGG Q RS C+ G VEE +C P KP +Q CNL C
Sbjct: 423 EHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAP-KPKVMQTCNLFDCPK 481
Query: 400 WSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV--------HE 451
W W +C+V+CG G+R R V C RG H C+ + + + E CV E
Sbjct: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGE--HVGGCNPQLKLHIKEECVIPIPCYKPKE 539
Query: 452 DCPLLSDQAW----------HVGT---------WGLCSKSCSSGTRRRQVICAI------ 486
P+ + W + T W CS +C G + R+V C +
Sbjct: 540 KSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQ 599
Query: 487 ----GPPSHC--GSLQHSKPVDVEPCNTQPCHLPQEVPSMQDVHT 525
P C L +P +E C+ P ++P +D T
Sbjct: 600 TETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSET 644
Score = 137 bits (345), Expect = 6e-32
Identities = 138/499 (27%), Positives = 193/499 (38%), Gaps = 79/499 (15%)
Query: 13 PAPGSSAPKVRRQSDTWGP---WSQ--WSPCSRTCGGGVSFRERPCYSQRRDGGS----- 62
P P S K D + P W W+ CS +CGGG+ R C + G
Sbjct: 400 PCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEE 459
Query: 63 -SCVGPARSH--RSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELN 119
C+ + ++C CP QC G +G RYR + + +
Sbjct: 460 WKCMYAPKPKVMQTCNLFDCPKWIA-MEWSQCTVTCG---RGLRYRVVLCINHRGEHVGG 515
Query: 120 CIPKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSK---QEDKCLR-- 174
C P+ +E V PC K V+ + EL+ ++ +E +
Sbjct: 516 CNPQ---LKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEP 572
Query: 175 CGGDGTTCYPVAGTFDANDLSRAVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEG 234
TTC P V+ V+ L + LP E EG
Sbjct: 573 WSACSTTCGPGV----------QVREVKCRVLLT---FTQTETELP--------EEECEG 611
Query: 235 DLAPERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPG-FSWSHGSWSDCSAEC 293
+ PT P ++E + P E +PL S + W + ++ C+A C
Sbjct: 612 P--------KLPTERPCLLEACDESP---ASRELDIPLPEDSETTYDWEYAGFTPCTATC 660
Query: 294 GGGHQSRLVFCTI--DHEAYPDHMCQRQPRP-ADRRSCNLHPCPETKRWKAGPWAPCSAS 350
GGHQ + C + D +C RP A ++CN PCP RW G W PCSA+
Sbjct: 661 VGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPP--RWHVGSWGPCSAT 718
Query: 351 CGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC-AAWSPEPWGECS 409
CG G Q+R VYC+ + EC KP A+QACN C W E W +CS
Sbjct: 719 CGVGIQTRDVYCLHPG----ETPAPPEECR--DEKPHALQACNQFDCPPGWHIEEWQQCS 772
Query: 410 VSCGVGVRKRSVTCRG--ERGSLLHTAACSLEDRPPLT--EPCVHEDCPLLSDQAWHVGT 465
+CG G + R VTCR GS L+ + L P + + C DCP VG
Sbjct: 773 RTCGGGTQNRRVTCRQLLTDGSFLNLSD-ELCQGPKASSHKSCARTDCP----PHLAVGD 827
Query: 466 WGLCSKSCSSGTRRRQVIC 484
W CS SC G +RR+ +C
Sbjct: 828 WSKCSVSCGVGIQRRKQVC 846
Score = 101 bits (251), Expect = 5e-21
Identities = 82/302 (27%), Positives = 114/302 (37%), Gaps = 67/302 (22%)
Query: 266 YEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHE-----AYPDHMCQRQP 320
Y++ PL R W H W+ CS CGGG Q R C + + C P
Sbjct: 413 YDHFQPLPR------WEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAP 466
Query: 321 RPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGI---------- 370
+P ++CNL CP +W A W+ C+ +CG G + R V CI+ G +
Sbjct: 467 KPKVMQTCNLFDCP---KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLH 523
Query: 371 --QEAVEEAECAGLPGKPPAI-------QACNLQRCA------AWSPEPWGECSVSCGVG 415
+E V C K P QA L+ + PEPW CS +CG G
Sbjct: 524 IKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPG 583
Query: 416 VRKRSVTCR-----GERGSLLHTAACSLEDRPPLTEPCVHEDC-----------PLLSDQ 459
V+ R V CR + + L C + P PC+ E C PL D
Sbjct: 584 VQVREVKCRVLLTFTQTETELPEEECE-GPKLPTERPCLLEACDESPASRELDIPLPEDS 642
Query: 460 A----WHVGTWGLCSKSCSSGTRRRQVICA------IGPPSHCGSLQHSKPVDVEPCNTQ 509
W + C+ +C G + +C S C + H P + CNT+
Sbjct: 643 ETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLC-DMVHRPPAMSQACNTE 701
Query: 510 PC 511
PC
Sbjct: 702 PC 703
Score = 101 bits (251), Expect = 5e-21
Identities = 69/241 (28%), Positives = 94/241 (39%), Gaps = 23/241 (9%)
Query: 281 WSHGSWSDCSAECG--GGHQSRLVFCTIDHEAYPDHMCQRQPRP-ADRRSCNLHPCPETK 337
W G+WS CSA CG G R + + + +C +P A CN+ CP
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPA-- 1485
Query: 338 RWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397
RW W+ CS SCG G SR V C + G + V CA +P + C C
Sbjct: 1486 RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAP-KDRPLGRKPCFGHPC 1544
Query: 398 AAWSPEPWGECSVSC---GVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCP 454
W EP C C V +++R C+ + C RP L C C
Sbjct: 1545 VQW--EPGNRCPGRCMGRAVRMQQRHTACQHNSSD----SNCDDRKRPTLRRNCTSGAC- 1597
Query: 455 LLSDQAWHVGTWGLCSKSCSSGTRRRQVIC----AIGPPSHCGSLQHSKPVDVEPCNTQP 510
D WH G W C+ +C G + R+V C + P + +Q KP+ C
Sbjct: 1598 ---DVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPS 1654
Query: 511 C 511
C
Sbjct: 1655 C 1655
Score = 93.2 bits (230), Expect = 1e-18
Identities = 60/187 (32%), Positives = 89/187 (47%), Gaps = 15/187 (8%)
Query: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDHEA-YPDHMCQRQPRPADRRSCNLHPCPETKRW 339
W GSW CSA CG G Q+R V+C E P C R +P ++CN CP W
Sbjct: 707 WHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEEC-RDEKPHALQACNQFDCPPG--W 763
Query: 340 KAGPWAPCSASCGGGSQSRSVYC--ISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397
W CS +CGGG+Q+R V C + +DG+ + + + C G K + ++C C
Sbjct: 764 HIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLN--LSDELCQG--PKASSHKSCARTDC 819
Query: 398 AAW-SPEPWGECSVSCGVGVRKRSVTCR--GERGSLLHTAACSLEDRP--PLTEPCVHED 452
+ W +CSVSCGVG+++R C+ +G + + D P PL C +
Sbjct: 820 PPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPE 879
Query: 453 CPLLSDQ 459
C + +
Sbjct: 880 CSKIKSE 886
Score = 57.4 bits (137), Expect = 8e-08
Identities = 42/158 (26%), Positives = 51/158 (32%), Gaps = 66/158 (41%)
Query: 272 LRRPSPGFS----------WSHGSWSDCSAECGGGHQSRLVFCTIDH-----EAYPDHMC 316
L++P GF W WS CS CG G+ SR V C + C
Sbjct: 1468 LQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRAC 1527
Query: 317 QRQPRPADRRSCNLHPC-----------------------------------------PE 335
+ RP R+ C HPC P
Sbjct: 1528 APKDRPLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPT 1587
Query: 336 TKR----------WKAGPWAPCSASCGGGSQSRSVYCI 363
+R W GPW PC+A+CG G QSR V CI
Sbjct: 1588 LRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCI 1625
Score = 46.2 bits (108), Expect = 2e-04
Identities = 25/89 (28%), Positives = 46/89 (51%), Gaps = 11/89 (12%)
Query: 1025 VVDASPGQRIRMTCRAEGFPPPAIEWQRDGQPVSSPRHQLQPDGSLVISRVAVEDGGFYT 1084
+V+A+ G + + C +G P P I W + G +S L +GSL++ V++E+ G Y
Sbjct: 1308 IVEAALGANVTIRCPVKGVPQPNITWLKRGGSLSG-NVSLLFNGSLLLQNVSLENEGTYV 1366
Query: 1085 CVAFNGQDR----------DQRWVQLRVL 1103
C+A N + ++RW + R++
Sbjct: 1367 CIATNALGKAVATSVLHLLERRWPESRIV 1395
Score = 45.1 bits (105), Expect = 4e-04
Identities = 32/102 (31%), Positives = 49/102 (48%), Gaps = 5/102 (4%)
Query: 900 VRLSCSDDTAPESQAAWQKDGQPI-SSDRHRLQFDGSLIIHPLQAEDAGTYSCGSTRPGR 958
V + C +S W+KDG+ + +S R + GSL IH L A D G Y C + G
Sbjct: 930 VIIKCPVRRFQKSLIQWEKDGRCLQNSKRLGITKSGSLKIHGLAAPDIGVYRCIA---GS 986
Query: 959 DSQKIQLRIIGGDMAVLSEAELSRFPQPRDPAQDFGQAGAAG 1000
+ + L++IG D +++ L R P P D +A + G
Sbjct: 987 AQETVVLKLIGTDNRLIARPAL-REPMREYPGMDHSEANSLG 1027
Score = 43.1 bits (100), Expect = 0.002
Identities = 25/71 (35%), Positives = 38/71 (53%), Gaps = 1/71 (1%)
Query: 884 LAGVEPSLVQAALGQLVRLSCSDDTAPESQAAWQKDGQPISSDRHRLQFDGSLIIHPLQA 943
L+ V +V+AALG V + C P+ W K G +S + L F+GSL++ +
Sbjct: 1301 LSVVVGGIVEAALGANVTIRCPVKGVPQPNITWLKRGGSLSGN-VSLLFNGSLLLQNVSL 1359
Query: 944 EDAGTYSCGST 954
E+ GTY C +T
Sbjct: 1360 ENEGTYVCIAT 1370
Score = 38.5 bits (88), Expect = 0.041
Identities = 23/76 (30%), Positives = 39/76 (51%), Gaps = 5/76 (6%)
Query: 1030 PGQRIRMTCRAEGFPPPAIEWQRDGQPV-SSPRHQLQPDGSLVISRVAVEDGGFYTCVAF 1088
P + + C F I+W++DG+ + +S R + GSL I +A D G Y C+A
Sbjct: 926 PNTSVIIKCPVRRFQKSLIQWEKDGRCLQNSKRLGITKSGSLKIHGLAAPDIGVYRCIAG 985
Query: 1089 NGQDRDQRWVQLRVLG 1104
+ Q+ V L+++G
Sbjct: 986 SAQET----VVLKLIG 997
Score = 38.1 bits (87), Expect = 0.053
Identities = 31/130 (23%), Positives = 47/130 (36%), Gaps = 26/130 (20%)
Query: 33 SQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARSHRSCRTESCPDGARDFRAEQCA 92
S WS CS +CG G R+ C + +G V P R+C + P G + C
Sbjct: 1490 SVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSP----RACAPKDRPLGRKPCFGHPCV 1545
Query: 93 EFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTP--CEPGKRDV-- 148
+ W P N+C C+ + +H + + C+ KR
Sbjct: 1546 Q------------WEP----GNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLR 1589
Query: 149 --CVDGSCRV 156
C G+C V
Sbjct: 1590 RNCTSGACDV 1599
Score = 32.7 bits (73), Expect = 2.2
Identities = 34/146 (23%), Positives = 53/146 (36%), Gaps = 21/146 (14%)
Query: 1050 WQRDGQPVS-SPRHQLQPDGSLVISRVAVEDGGFYTCVAFNGQDRDQRWVQLRVLGELTI 1108
W +DG + S + L G + I ++ G Y C N D + I
Sbjct: 1227 WTKDGTLLQPSVKIILDGTGKIQIQNPTRKEQGIYECSVANHLGSDVESSSVLYAEAPVI 1286
Query: 1109 SGLPPTVTVPE----------------GDTARLLCVVAG-ESVNIRWSRNGLPVQADGHR 1151
+ +T PE G + C V G NI W + G + +
Sbjct: 1287 LSVERNITKPEHNHLSVVVGGIVEAALGANVTIRCPVKGVPQPNITWLKRGGSLSGN--- 1343
Query: 1152 VHQSPDGTLLIYNLRARDEGSYTCSA 1177
V +G+LL+ N+ +EG+Y C A
Sbjct: 1344 VSLLFNGSLLLQNVSLENEGTYVCIA 1369
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 259 bits (663), Expect = 9e-69
Identities = 161/491 (32%), Positives = 229/491 (46%), Gaps = 60/491 (12%)
Query: 3 LLLLVPLLLAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGS 62
LL L LLL+ S D WGPWS+ CSRTCGGG S+ R C S +
Sbjct: 13 LLFLAFLLLSSRTARSEEDRDGLWDAWGPWSE---CSRTCGGGASYSLRRCLSSK----- 64
Query: 63 SCVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAP-NKCELNCI 121
SC G +R+C CP A DFRA+QC+ + + G+ Y WLP + P N C L C
Sbjct: 65 SCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQ 124
Query: 122 PKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTT 181
KG + V+DGT C D+C+ G C++VGCDH+L S+ +ED C C GDG+T
Sbjct: 125 AKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGST 184
Query: 182 CYPVAGTFDAN-DLSRAVKNVRGEYYLNGHWTI------------------EAARALPAA 222
C V G + + +++ V Y + H + + +L +
Sbjct: 185 CRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSST 244
Query: 223 STILHYERGAEGDLAPER--LHARGPTSEPLVIEL-ISQEPNPGVHYEYHLPLRRPSPGF 279
T L + P++ L GP + ++++ S + V + ++ P+
Sbjct: 245 GTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIH----- 299
Query: 280 SWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQRQP---RPADR-RSCNLHPC 333
W + CSA CGGG+Q C + D C P +P + + CNL PC
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
Query: 334 PET---------------KRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAE 378
P + RW+A PW CS+SCGGG QSR+V C+ D G +VEE +
Sbjct: 360 PASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
Query: 379 CAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSL 438
C P K P Q CN+ C W + W C+V+CG G+R R V C RG +HT CS
Sbjct: 420 CMYTP-KMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSP 476
Query: 439 EDRPPLTEPCV 449
+ +P + E C+
Sbjct: 477 KTKPHIKEECI 487
Score = 93.2 bits (230), Expect = 1e-18
Identities = 65/210 (30%), Positives = 85/210 (40%), Gaps = 35/210 (16%)
Query: 334 PETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPG--KP-PAIQ 390
P RW+ + PCSA+CGGG Q S C V + C P KP P +Q
Sbjct: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRS---NRVVADQYCHYYPENIKPKPKLQ 352
Query: 391 ACNLQRCAA------------------WSPEPWGECSVSCGVGVRKRSVTCRGE----RG 428
CNL C A W PW CS SCG G++ R+V+C E
Sbjct: 353 ECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHV 412
Query: 429 SLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGP 488
+ + C + P+ +PC DCP W W C+ +C G R R V+C
Sbjct: 413 TSVEEWKCMYTPKMPIAQPCNIFDCP-----KWLAQEWSPCTVTCGQGLRYRVVLCIDHR 467
Query: 489 PSHCGSLQ-HSKPVDVEPCNT-QPCHLPQE 516
H G +KP E C PC+ P+E
Sbjct: 468 GMHTGGCSPKTKPHIKEECIVPTPCYKPKE 497
Score = 33.5 bits (75), Expect = 1.3
Identities = 37/154 (24%), Positives = 56/154 (36%), Gaps = 20/154 (12%)
Query: 11 LAPAPGSSAPKVRRQSDTWGP---W--SQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCV 65
L P P S K D + P W + W+ CS +CGGG+ R C + G + V
Sbjct: 356 LDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV 415
Query: 66 GPARS--------HRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCE 117
+ + C CP + A++ + QG RYR +
Sbjct: 416 EEWKCMYTPKMPIAQPCNIFDCP----KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHT 471
Query: 118 LNCIPKGENFYYKHREAVVDGTPCEPGKRDVCVD 151
C PK + +E + TPC K + V+
Sbjct: 472 GGCSPKTKPHI---KEECIVPTPCYKPKEKLPVE 502
Score = 32.7 bits (73), Expect = 2.2
Identities = 20/67 (29%), Positives = 28/67 (41%), Gaps = 5/67 (7%)
Query: 399 AWSPEPWGECSVSCGVGVR---KRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPL 455
AW P W ECS +CG G +R ++ + G + CS D PP + C
Sbjct: 38 AWGP--WSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSA 95
Query: 456 LSDQAWH 462
+D H
Sbjct: 96 HNDVKHH 102
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 256 bits (655), Expect = 7e-68
Identities = 175/553 (31%), Positives = 228/553 (41%), Gaps = 113/553 (20%)
Query: 64 CVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPY--YSAPNKCELNCI 121
C G + R+C CP D RA QCA F+ EF G+ Y+W P+ +CELNC
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
Query: 122 PKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTT 181
P+G FY +H E V DGT C+PG D+CV G C GCD L S ++ D C CGGD +T
Sbjct: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
Query: 182 CYPVAGTFD---------------ANDLSRAVKNVR------------GEYYLNGHWTIE 214
C V+G A L + +R G +NG+W ++
Sbjct: 484 CRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVD 543
Query: 215 AARALPAASTILHYERGAEGDLAPERLHARGPTSEPLVIELISQEPNPGVHYEYHL---- 270
+ A T+ Y R + E L A GPT++P+ + +I QE NPGV Y+Y +
Sbjct: 544 PPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVISSPP 603
Query: 271 -------------------------------PLRRP-----------------------S 276
P R P S
Sbjct: 604 PILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTPLGS 663
Query: 277 PGFSWSHGSWSDCSAECGGGHQSRLVFCTIDH--EAYPDHMCQRQPRP-ADRRSCNLHPC 333
P W S CSA CG G + C E + C RP A C+ PC
Sbjct: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPC 723
Query: 334 PETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACN 393
P W+AG W CS SCG G+Q R + C G G +V C LP +P Q+C
Sbjct: 724 PPY--WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGG-GSSVPPERCGHLP-RPNITQSCQ 779
Query: 394 LQRCAAWS-PEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAAC-SLEDRPPLTEPCVHE 451
L+ C W PW +CSV CG G R R V C G G + C S +PP E C
Sbjct: 780 LRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMG 839
Query: 452 DCPLLSDQAWHVGTW-GLCSKSCSSGTRRRQVIC-----AIGP---PSHCGSLQH----S 498
C AW W CS C +G +RR V+C A+GP + G+ Q S
Sbjct: 840 PC----TTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGS 895
Query: 499 KPVDVEPCNTQPC 511
+P D+ C+ PC
Sbjct: 896 RPPDMRACSLGPC 908
Score = 155 bits (391), Expect = 3e-37
Identities = 90/261 (34%), Positives = 122/261 (46%), Gaps = 36/261 (13%)
Query: 275 PSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDH----EAYPDHMCQRQPRPADRRSCNL 330
P P + W G W+ CS CG G Q R + C + + P C PRP +SC L
Sbjct: 722 PCPPY-WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL 780
Query: 331 HPCPETKRWKAG-PWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAI 389
C W+ G PW+ CS CG G +SR V C+ ++G + V E ECA P +PP+
Sbjct: 781 RLCGH---WEVGSPWSQCSVRCGRGQRSRQVRCVGNNG----DEVSEQECASGPPQPPSR 833
Query: 390 QACNLQRCA-AWSPEPWG-ECSVSCGVGVRKRSVTCRGERGSLLHTA---------ACSL 438
+AC++ C AW W +CS CG G+++RSV C G +L +C
Sbjct: 834 EACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPT 893
Query: 439 EDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICA--------IGPPS 490
RPP C C W+ G WG CS C SGT+RR +IC + PS
Sbjct: 894 GSRPPDMRACSLGPCE--RTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPS 951
Query: 491 HCGSLQHSKPVDVEPCNTQPC 511
+C L +P ++PC Q C
Sbjct: 952 NCSHL--PRPPALQPCQGQAC 970
Score = 141 bits (355), Expect = 4e-33
Identities = 85/247 (34%), Positives = 115/247 (46%), Gaps = 23/247 (9%)
Query: 281 WSHGS-WSDCSAECGGGHQSRLVFCTIDH--EAYPDHMCQRQPRPADRRSCNLHPCPETK 337
W GS WS CS CG G +SR V C ++ E P+P R +C++ PC T
Sbjct: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC--TT 843
Query: 338 RWKAGPWAP-CSASCGGGSQSRSVYCISSDGAGIQEAVEEA-----ECAGLPGKPPAIQA 391
W W+ CSA CG G Q RSV C+ S GA + EA + +PP ++A
Sbjct: 844 AWFHSDWSSKCSAECGTGIQRRSVVCLGS-GAALGPGQGEAGAGTGQSCPTGSRPPDMRA 902
Query: 392 CNLQRCAA---WSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAA---CSLEDRPPLT 445
C+L C W PWGECS CG G ++R + C + G+ + + CS RPP
Sbjct: 903 CSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPAL 962
Query: 446 EPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVIC-AIGPPSHCGSLQHSKPVDVE 504
+PC + C W W CS+SC GT+ R+V C + +P
Sbjct: 963 QPCQGQAC----QDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKR 1018
Query: 505 PCNTQPC 511
PCN+QPC
Sbjct: 1019 PCNSQPC 1025
Score = 125 bits (314), Expect = 3e-28
Identities = 69/186 (37%), Positives = 85/186 (45%), Gaps = 16/186 (8%)
Query: 280 SWSHGSWSD-CSAECGGGHQSRLVFCTIDHEAY----------PDHMCQRQPRPADRRSC 328
+W H WS CSAECG G Q R V C A C RP D R+C
Sbjct: 844 AWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRAC 903
Query: 329 NLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPA 388
+L PC T RW GPW CS+ CG G+Q R + C+S G + C+ LP +PPA
Sbjct: 904 SLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEF-NVTSPSNCSHLP-RPPA 961
Query: 389 IQACNLQRCA-AWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEP 447
+Q C Q C W PW CS SC G + R V C +L + C + RP P
Sbjct: 962 LQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTL--STRCPPQLRPSRKRP 1019
Query: 448 CVHEDC 453
C + C
Sbjct: 1020 CNSQPC 1025
Score = 58.2 bits (139), Expect = 5e-08
Identities = 80/324 (24%), Positives = 112/324 (34%), Gaps = 49/324 (15%)
Query: 34 QWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARSH-------RSCRTESCPDGARDF 86
+W+ CSR+CG G R+ C + GGSS H +SC+ C
Sbjct: 731 EWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGS 790
Query: 87 RAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPGKR 146
QC+ G +G+R R ++ C+ G N + G P +P R
Sbjct: 791 PWSQCSVRCG---RGQRSR-----------QVRCV--GNNGDEVSEQECASGPP-QPPSR 833
Query: 147 DVCVDGSCRVVGCDHELDSSKQEDKC--------LRCGGDGTTCYPVAGTFDANDLSRAV 198
+ C G C H SSK +C + C G G P G A
Sbjct: 834 EACDMGPCTTAWF-HSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCP 892
Query: 199 KNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAPERLHARGPTSEPLVIELISQ 258
R + A P T Y G G+ + E V +L ++
Sbjct: 893 TGSRPP-------DMRACSLGPCERTWRWYT-GPWGECSSECGSGTQRRDIICVSKLGTE 944
Query: 259 EPNPGVHYEYHLP---LRRPSPGFS----WSHGSWSDCSAECGGGHQSRLVFCTIDHEAY 311
HLP +P G + W WS CS C GG Q+R V C ++
Sbjct: 945 FNVTSPSNCSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTL 1004
Query: 312 PDHMCQRQPRPADRRSCNLHPCPE 335
C Q RP+ +R CN PC +
Sbjct: 1005 STR-CPPQLRPSRKRPCNSQPCSQ 1027
Score = 42.7 bits (99), Expect = 0.002
Identities = 15/25 (60%), Positives = 17/25 (68%)
Query: 29 WGPWSQWSPCSRTCGGGVSFRERPC 53
WGPW QW+ CS+ CG GV R R C
Sbjct: 47 WGPWVQWASCSQPCGVGVQRRSRTC 71
Score = 40.0 bits (92), Expect = 0.014
Identities = 25/75 (33%), Positives = 34/75 (45%), Gaps = 11/75 (14%)
Query: 8 PLLLAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGSSC--- 64
P L P G + D W + WSPCSR+C GG RE C S + + C
Sbjct: 959 PPALQPCQGQAC------QDRWFS-TPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQ 1011
Query: 65 VGPARSHRSCRTESC 79
+ P+R R C ++ C
Sbjct: 1012 LRPSRK-RPCNSQPC 1025
Score = 36.2 bits (82), Expect = 0.20
Identities = 23/77 (29%), Positives = 35/77 (45%), Gaps = 18/77 (23%)
Query: 1182 QAVSRSTEVKVVSPAPTAQPRDPG-------RDCVDQP-----------ELANCDLILQA 1223
Q +++ EV+ +S T R P R C QP +C L++QA
Sbjct: 987 QGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQRPDDQCKDSSPHCPLVVQA 1046
Query: 1224 QLCGNEYYSSFCCASCS 1240
+LC YY++ CC SC+
Sbjct: 1047 RLCVYPYYTATCCRSCA 1063
Score = 35.8 bits (81), Expect = 0.26
Identities = 64/239 (26%), Positives = 88/239 (36%), Gaps = 33/239 (13%)
Query: 400 WSP-EPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSD 458
W P W CS CGVGV++RS TC+ L + L RPP H + L
Sbjct: 47 WGPWVQWASCSQPCGVGVQRRSRTCQLPTVQL--HPSLPLPPRPPR-----HPEALLPRG 99
Query: 459 QAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCG--------SLQHSKPVD-VEPCNTQ 509
Q T + +R R GP SH G + + S+ D ++P
Sbjct: 100 QGPRPQTSPETLPLYRTQSRGRGGPLR-GPASHLGREETQEIRAARRSRLRDPIKPGMFG 158
Query: 510 PCHLPQEVPSMQDVHTPASNPWMPLGPQESPASDSRGQWWAAQEHPSARGDHRGERGDPR 569
+P +P ++ P S P E SRG+ A P+ R + G P+
Sbjct: 159 YGRVPFALPLHRNRRHPRSPP-----RSELSLISSRGE--EAIPSPTPRAEPFSANGSPQ 211
Query: 570 GD-QGTHLSALGPAPS---LQQPPYQQPLRSGSGPHDCRHSPH----GCCPDGHTASLG 620
+ T LS P+P L Q + + P RH P G P T SLG
Sbjct: 212 TELPPTELSVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHHPRAQASGTEPPSPTHSLG 270
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 234 bits (596), Expect = 5e-61
Identities = 156/495 (31%), Positives = 200/495 (40%), Gaps = 100/495 (20%)
Query: 64 CVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPY--YSAPNKCELNCI 121
C G + R+C CP D RA QCA F+ EF G+ Y+W P+ +CELNC
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
Query: 122 PKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTT 181
P+G FY +H E V DGT C+PG D+CV G C GCD L S ++ D C CGGD +T
Sbjct: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
Query: 182 CYPVAGT---------------FDANDLSRAVKNVR------------GEYYLNGHWTIE 214
C V+G A L + +R G +NG+W ++
Sbjct: 484 CRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVD 543
Query: 215 AARALPAASTILHYERGAEGDLAPERLHARGPTSEPLVIELISQEPNPGVHYEYHL---- 270
+ A T+ Y R + E L A GPT++P+ + +I QE NPGV Y+Y +
Sbjct: 544 PPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVISSPP 603
Query: 271 -------------------------------PLRRP-----------------------S 276
P R P S
Sbjct: 604 PILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTPLGS 663
Query: 277 PGFSWSHGSWSDCSAECGGGHQSRLVFCTI--DHEAYPDHMCQRQPR-PADRRSCNLHPC 333
P W S CSA CG G + C E + C R PA C+ PC
Sbjct: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPC 723
Query: 334 PETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACN 393
P W+AG W CS SCG G+Q R + C G G +V C LP +P Q+C
Sbjct: 724 P--PYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGG-GSSVPPERCGHLP-RPNITQSCQ 779
Query: 394 LQRCAAWS-PEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAAC-SLEDRPPLTEPCVHE 451
L+ C W PW +CSV CG G R R V C G G + C S +PP E C
Sbjct: 780 LRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMG 839
Query: 452 DCPLLSDQAWHVGTW 466
C AW W
Sbjct: 840 PC----TTAWFHSDW 850
Score = 65.1 bits (157), Expect = 4e-10
Identities = 42/124 (33%), Positives = 53/124 (42%), Gaps = 16/124 (12%)
Query: 398 AAWSPEPWGECSVSCGVGVRKRSVTCRG-ERGSLLHTAACSLEDRPPLT-EPCVHEDCPL 455
A W CS SCG GV + C E G L +C+ RPP + EPC CP
Sbjct: 666 AYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCP- 724
Query: 456 LSDQAWHVGTWGLCSKSCSSGTRRRQVIC--------AIGPPSHCGSLQHSKPVDVEPCN 507
W G W CS+SC GT+ RQ+ C + PP CG L +P + C
Sbjct: 725 ---PYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHL--PRPNITQSCQ 779
Query: 508 TQPC 511
+ C
Sbjct: 780 LRLC 783
Score = 42.7 bits (99), Expect = 0.002
Identities = 15/25 (60%), Positives = 17/25 (68%)
Query: 29 WGPWSQWSPCSRTCGGGVSFRERPC 53
WGPW QW+ CS+ CG GV R R C
Sbjct: 47 WGPWVQWASCSQPCGVGVQRRSRTC 71
Score = 38.5 bits (88), Expect = 0.041
Identities = 35/129 (27%), Positives = 50/129 (38%), Gaps = 26/129 (20%)
Query: 34 QWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARS--------HRSCRTESCPDGARD 85
+W+ CSR+CG G R+ C Q GG S V P R +SC+ C
Sbjct: 731 EWTSCSRSCGPGTQHRQLQC-RQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVG 789
Query: 86 FRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPGK 145
QC+ G +G+R R ++ C+ G N + G P +P
Sbjct: 790 SPWSQCSVRCG---RGQRSR-----------QVRCV--GNNGDEVSEQECASGPP-QPPS 832
Query: 146 RDVCVDGSC 154
R+ C G C
Sbjct: 833 REACDMGPC 841
Score = 35.8 bits (81), Expect = 0.26
Identities = 64/239 (26%), Positives = 88/239 (36%), Gaps = 33/239 (13%)
Query: 400 WSP-EPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSD 458
W P W CS CGVGV++RS TC+ L + L RPP H + L
Sbjct: 47 WGPWVQWASCSQPCGVGVQRRSRTCQLPTVQL--HPSLPLPPRPPR-----HPEALLPRG 99
Query: 459 QAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCG--------SLQHSKPVD-VEPCNTQ 509
Q T + +R R GP SH G + + S+ D ++P
Sbjct: 100 QGPRPQTSPETLPLYRTQSRGRGGPLR-GPASHLGREETQEIRAARRSRLRDPIKPGMFG 158
Query: 510 PCHLPQEVPSMQDVHTPASNPWMPLGPQESPASDSRGQWWAAQEHPSARGDHRGERGDPR 569
+P +P ++ P S P E SRG+ A P+ R + G P+
Sbjct: 159 YGRVPFALPLHRNRRHPRSPP-----RSELSLISSRGE--EAIPSPTPRAEPFSANGSPQ 211
Query: 570 GD-QGTHLSALGPAPS---LQQPPYQQPLRSGSGPHDCRHSPH----GCCPDGHTASLG 620
+ T LS P+P L Q + + P RH P G P T SLG
Sbjct: 212 TELPPTELSVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHHPRAQASGTEPPSPTHSLG 270
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 233 bits (593), Expect = 1e-60
Identities = 141/418 (33%), Positives = 194/418 (46%), Gaps = 58/418 (13%)
Query: 28 TWGPWSQWSPCSRTCGGGVSFRERPCYSQ-RRDGGSSCVGPARSHRSCRTESCPDG-ARD 85
+WG W W CSRTCGGGV + R C + ++GG C G +RSC E CPD +
Sbjct: 561 SWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKT 620
Query: 86 FRAEQCA---EFDGAEF-QGRRYRWLPYY---SAPNKCELNCIPKGENFYYKHREAVVDG 138
FR EQC EF A F G W+P Y S ++C+L C KG +++ + VVDG
Sbjct: 621 FREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDG 680
Query: 139 TPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDA------- 191
TPC P VCV G C GCD +DS K+ DKC CGG+G+TC ++G+ +
Sbjct: 681 TPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHD 740
Query: 192 -----------------------NDLSRAVKNVRGEYYLNGHWTIEA-ARALPAASTILH 227
N A+K G Y LNG +T+ + + +L
Sbjct: 741 IITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLR 800
Query: 228 YERGAEGDLAPERLHARGPTSEPLVIEL--ISQEPNPGVHYEYHLPLRRPS----PGFS- 280
Y + A ER+ + P EPL I++ + P + Y Y + ++ S P FS
Sbjct: 801 Y---SGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFSA 857
Query: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRWK 340
W W +CS C G Q RLV C D P C ++ +PA R C HPCP+ W+
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECR-DINGQPASECAKEVKPASTRPCADHPCPQ---WQ 913
Query: 341 AGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCA 398
G W+ CS +CG G + RS+ C+S DG + C L I C + C+
Sbjct: 914 LGEWSSCSKTCGKGYKKRSLKCLSHDGG----VLSHESCDPLKKPKHFIDFCTMAECS 967
Score = 74.7 bits (182), Expect = 5e-13
Identities = 38/105 (36%), Positives = 52/105 (49%), Gaps = 11/105 (10%)
Query: 398 AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLS 457
+AW E WGECS SC +G ++R V CR G + C+ E +P T PC CP
Sbjct: 856 SAWVIEEWGECSKSCELGWQRRLVECRDINGQ--PASECAKEVKPASTRPCADHPCP--- 910
Query: 458 DQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVD 502
W +G W CSK+C G ++R + C SH G + + D
Sbjct: 911 --QWQLGEWSSCSKTCGKGYKKRSLKCL----SHDGGVLSHESCD 949
Score = 64.3 bits (155), Expect = 7e-10
Identities = 36/121 (29%), Positives = 48/121 (39%), Gaps = 8/121 (6%)
Query: 334 PETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACN 393
P W W CS SC G Q R V C +G E +E KP + + C
Sbjct: 853 PTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEV-------KPASTRPCA 905
Query: 394 LQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPP-LTEPCVHED 452
C W W CS +CG G +KRS+ C G +L +C +P + C +
Sbjct: 906 DHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAE 965
Query: 453 C 453
C
Sbjct: 966 C 966
Score = 44.7 bits (104), Expect = 6e-04
Identities = 23/55 (41%), Positives = 26/55 (47%), Gaps = 5/55 (9%)
Query: 460 AWHVGTWGLCSKSCSSGTRRRQVICAI---GPPSHCGSLQHSKPVDVEPCNTQPC 511
AW + WG CSKSC G +RR V C P S C + KP PC PC
Sbjct: 857 AWVIEEWGECSKSCELGWQRRLVECRDINGQPASECA--KEVKPASTRPCADHPC 909
Score = 38.5 bits (88), Expect = 0.041
Identities = 42/184 (22%), Positives = 64/184 (34%), Gaps = 27/184 (14%)
Query: 343 PWAPCSASCGGGSQSRSVYCISS---DGAGIQEAVEEAECAGLPGKPPAIQACNLQRC-- 397
PW+PCSA Y I+S +G G + LPG P ++C
Sbjct: 442 PWSPCSA-----------YMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQF 490
Query: 398 -----AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHED 452
+ P+ CS G + C+ + +C E + + CV++
Sbjct: 491 TFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCG-EGKWCINGKCVNKT 549
Query: 453 CPLLSDQAWHV-----GTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCN 507
D +H G WG CS++C G + C P + G K V CN
Sbjct: 550 DRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCN 609
Query: 508 TQPC 511
+ C
Sbjct: 610 LEDC 613
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 230 bits (587), Expect = 6e-60
Identities = 166/514 (32%), Positives = 231/514 (44%), Gaps = 72/514 (14%)
Query: 23 RRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRR-DGGSSCVGPARSHRSCRTESCPD 81
++Q WG W+++ CSRTCG GV FR R C + +GG C G ++ C TE C
Sbjct: 548 QKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQK 607
Query: 82 GARDFRAEQCAEFDGA-EFQGRRYRWLPY-YSAPNK-CELNCIPKGENFYYKHREAVVDG 138
DFRA+QC + + E+Q ++ WLPY + P K C L C K ++ V DG
Sbjct: 608 HFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDG 667
Query: 139 TPCE-PGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTF-------- 189
T C +CV G C VGCD E+ S+K EDKC CGGD + C V GTF
Sbjct: 668 THCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLG 727
Query: 190 -------------------DANDLSRAVKN-VRGEYYLNGHWTIEAARALPAASTILHYE 229
+A+ A+KN G Y LNG E A++ + ++
Sbjct: 728 YLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKG--EEAKSRTFIDLGVEWD 785
Query: 230 RGAEGDLAPERLHARGPTSEPLVIELISQE--PNPGVHYEYHL------------PLRRP 275
E D+ E LH GP +P+++ +I QE + Y+Y + ++
Sbjct: 786 YNIEDDI--ESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEE 843
Query: 276 SPGFSWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQ--RQPRPADRRSCNLH 331
F W+ SWS CS CGGG Q C D++ C+ ++P+P RR CN+
Sbjct: 844 LDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPI-RRMCNIQ 902
Query: 332 PCPETKRWKAGPWAPCSASCG-GGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQ 390
C W A W C+ +CG G Q R+V C+ G +V C G +P + +
Sbjct: 903 ECTH-PLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG--DRPESRR 959
Query: 391 ACNLQRC-AAWSPEPWGECSVSCGVGVRKRSVTCR------GERGSLLHTAACSL---ED 440
CN C A W PW ECSV+CG G R V CR GE+ + AC L D
Sbjct: 960 PCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVR--ACQLPPCND 1017
Query: 441 RPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCS 474
P L + + +L+ G LC +SCS
Sbjct: 1018 EPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCS 1051
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 230 bits (587), Expect = 6e-60
Identities = 157/473 (33%), Positives = 202/473 (42%), Gaps = 79/473 (16%)
Query: 24 RQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQR-RDGGSSCVGPARSHRSCRTESCPDG 82
R +W W + PCSRTCGGGV R C + +GG C G +RSC E CP
Sbjct: 514 RVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSS 573
Query: 83 A--RDFRAEQCAEFDGAEFQGRRYR----WLPYYSAPN---KCELNCIPKGENFYYKHRE 133
A + FR EQC F+G R W+P YS + KC+L C G ++Y
Sbjct: 574 ASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAP 633
Query: 134 AVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFD--- 190
VVDGT C P VCV G C GCD L S K+ DKC CGGD +C V G F
Sbjct: 634 KVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPM 693
Query: 191 ---------------------------ANDLSRAVKNVRGEYYLNGHWTIEAA-RALPAA 222
+D A+KN +G+Y LNGH+ + A R L
Sbjct: 694 HGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVK 753
Query: 223 STILHYERGAEGDLAPERLHARGPTSEPLVIELIS--QEPNPGVHYEYHLPLRRPSPGFS 280
++L Y A E L A P EPL +E++S + P V Y ++LP + P
Sbjct: 754 GSLLRYSGTGT---AVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLP-KEPR---- 805
Query: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRWK 340
E H ++ H + + + +P DR RW
Sbjct: 806 -----------EDKSSHPKDPRGPSVLHNSVLS-LSNQVEQPDDRPPA---------RWV 844
Query: 341 AGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAW 400
AG W PCSASCG G Q R+V C S G A + A +P QAC + C W
Sbjct: 845 AGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAH------RPVETQACG-EPCPTW 897
Query: 401 SPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDC 453
W CS SCG G ++RS+ C G G LL C+L +P + CV C
Sbjct: 898 ELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 80.9 bits (198), Expect = 7e-15
Identities = 46/121 (38%), Positives = 57/121 (47%), Gaps = 18/121 (14%)
Query: 398 AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLS 457
A W WG CS SCG G++KR+V CRG G AC RP T+ C E CP
Sbjct: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRT-VPACDAAHRPVETQAC-GEPCP--- 895
Query: 458 DQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSL-------QHSKPVDVEPCNTQP 510
W + W CSKSC G +RR + C H G L H KP +++ C +P
Sbjct: 896 --TWELSAWSPCSKSCGRGFQRRSLKCV----GHGGRLLARDQCNLHRKPQELDFCVLRP 949
Query: 511 C 511
C
Sbjct: 950 C 950
Score = 35.4 bits (80), Expect = 0.34
Identities = 44/199 (22%), Positives = 69/199 (34%), Gaps = 18/199 (9%)
Query: 340 KAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAI-----QACNL 394
+A PW+ CSA+ + G G + ++ LP P Q C L
Sbjct: 399 RANPWSACSAAI--------ITDFLDSGHGDCLLDQPSKPISLPEDLPGASYTLSQQCEL 450
Query: 395 QRCAAWSPEPWGE-CSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV--HE 451
P P+ + C+ G K + C+ +C E + L CV H
Sbjct: 451 AFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCG-EGKLCLKGACVERHN 509
Query: 452 DCPLLSDQAWHV-GTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQP 510
D +W +G CS++C G + + C P++ G V CN +P
Sbjct: 510 LNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEP 569
Query: 511 CHLPQEVPSMQDVHTPASN 529
C S ++ A N
Sbjct: 570 CPSSASGKSFREEQCEAFN 588
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 228 bits (582), Expect = 2e-59
Identities = 159/519 (30%), Positives = 215/519 (41%), Gaps = 75/519 (14%)
Query: 58 RDGGSSCVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPN--K 115
R SC+G R ++ C T CP+ +R R QCA ++ F GR Y W P+ K
Sbjct: 285 RSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRK 344
Query: 116 CELNCIPKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRC 175
CELNC G FY + E V+DGTPC+ +CV G C+ +GCD L S K DKC C
Sbjct: 345 CELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVC 404
Query: 176 GGDGTTCYPVAGTFD---------------------------ANDLSRAVKNVRGEYYLN 208
GGD T C V+G F ++ A+++ G +N
Sbjct: 405 GGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIIN 464
Query: 209 GHWTIEAARALPAASTILHYERGAE-GDLAPERLHARGPTSEPLVIELISQEPNPGVHYE 267
G+W I+ T+ Y+R E A E A GPT+E L + +I Q+PNPGVHYE
Sbjct: 465 GNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYE 524
Query: 268 YHL-----------PLRRPSPGFSWS--HGSWSDCSAECGGGHQSRLVFCTIDHEAYPDH 314
Y + P RRP F+ S E G ++ + E +
Sbjct: 525 YVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSE 584
Query: 315 MCQRQP-RPADRRSCN-----LHPCPETKR------WKAGPWAPCSASCGGGSQSRSVYC 362
Q P R DR S + + P P+ R WK CS +CG GSQ C
Sbjct: 585 SAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRC 644
Query: 363 ISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAA-WSPEPWGECSVSCGVGVRKRSV 421
+ E E+ C P + CN+ C A W W ECS +CG+G++ R V
Sbjct: 645 VH---RSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQV 701
Query: 422 TCR---GERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGT-WGLCSKSCSSGT 477
CR R + C ++P T C + C W + T W CS C G
Sbjct: 702 LCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKIC-----SEWQIRTDWTSCSVPCGVGQ 756
Query: 478 RRRQVICA-----IGPPSHCGSLQHSKPVDVEPCNTQPC 511
R R V C + C +P D+E C+ PC
Sbjct: 757 RTRDVKCVSNIGDVVDDEECN--MKLRPNDIENCDMGPC 793
Score = 140 bits (352), Expect = 1e-32
Identities = 88/255 (34%), Positives = 120/255 (47%), Gaps = 35/255 (13%)
Query: 275 PSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPD-------HMCQRQPRPADRRS 327
P P F W G WS+CS CG G Q R V C + Y + + CQ +P +
Sbjct: 675 PCPAF-WDIGEWSECSKTCGLGMQHRQVLC---RQVYANRSLTVQPYRCQHLEKPETTST 730
Query: 328 CNLHPCPETKRWKAGP-WAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKP 386
C L C E W+ W CS CG G ++R V C+S+ G + V++ EC + +P
Sbjct: 731 CQLKICSE---WQIRTDWTSCSVPCGVGQRTRDVKCVSNIG----DVVDDEEC-NMKLRP 782
Query: 387 PAIQACNLQRCA-AWSPEPWGE-CSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPL 444
I+ C++ CA +W W E CS CG GVR RSV C S L C +RP
Sbjct: 783 NDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCG-NNRPAE 841
Query: 445 TEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICA--------IGPPSHCGSLQ 496
PC ++ P W G+W CS C SGT++R+VIC + PS C L+
Sbjct: 842 ATPC--DNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLE 899
Query: 497 HSKPVDVEPCNTQPC 511
KP + C+ +PC
Sbjct: 900 --KPPSQQSCHLKPC 912
Score = 115 bits (289), Expect = 2e-25
Identities = 74/242 (30%), Positives = 106/242 (43%), Gaps = 35/242 (14%)
Query: 286 WSDCSAECGGGHQSRLVFCTID-HEAYPDHMCQRQPRPADRRSCNLHPCPETKRWKAGPW 344
W+ CS CG G ++R V C + + D C + RP D +C++ PC K W W
Sbjct: 745 WTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPC--AKSWFLTEW 802
Query: 345 AP-CSASCGGGSQSRSVYCISS-------DGAGIQEAVEEAECAGLP--GKPPAIQACNL 394
+ CSA CG G ++RSV C+++ +G G E C P GK
Sbjct: 803 SERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATPCDNGPCTGK--------- 853
Query: 395 QRCAAWSPEPWGECSVSCGVGVRKRSVTC---RGERGSLLHTAACSLEDRPPLTEPCVHE 451
W W +CS+ CG G ++R V C + +L + CS ++PP + C +
Sbjct: 854 ---VEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLK 910
Query: 452 DCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSL--QHSKPVDVEPCNTQ 509
C W W +CSKSC G R R+V C + +L KP + E CN Q
Sbjct: 911 PC----GAKWFSTEWSMCSKSCQGGFRVREVRC-LSDDMTLSNLCDPQLKPEERESCNPQ 965
Query: 510 PC 511
C
Sbjct: 966 DC 967
Score = 115 bits (289), Expect = 2e-25
Identities = 67/177 (37%), Positives = 92/177 (51%), Gaps = 8/177 (4%)
Query: 280 SWSHGSWSD-CSAECGGGHQSRLVFCTIDH-EAYPDHMCQRQPRPADRRSCNLHPCPETK 337
SW WS+ CSAECG G ++R V C +H + P C RPA+ C+ PC
Sbjct: 796 SWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNN-RPAEATPCDNGPCTGKV 854
Query: 338 RWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397
W AG W+ CS CG G+Q R V C+ + A E ++ +EC+ L KPP+ Q+C+L+ C
Sbjct: 855 EWFAGSWSQCSIECGSGTQQREVICVRKN-ADTFEVLDPSECSFLE-KPPSQQSCHLKPC 912
Query: 398 AA-WSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDC 453
A W W CS SC G R R V C + +L + C + +P E C +DC
Sbjct: 913 GAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTL--SNLCDPQLKPEERESCNPQDC 967
Score = 77.4 bits (189), Expect = 8e-14
Identities = 47/143 (32%), Positives = 64/143 (44%), Gaps = 13/143 (9%)
Query: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDH----EAYPDHMCQRQPRPADRRSCNLHPCPET 336
W GSWS CS ECG G Q R V C + E C +P ++SC+L PC
Sbjct: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGA- 914
Query: 337 KRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQR 396
+W + W+ CS SC GG + R V C+S D + + KP ++CN Q
Sbjct: 915 -KWFSTEWSMCSKSCQGGFRVREVRCLSDD-------MTLSNLCDPQLKPEERESCNPQD 966
Query: 397 CAAWSPEPWGECSVSCGVGVRKR 419
C E + +C V V+ R
Sbjct: 967 CVPEVDENCKDKYYNCNVVVQAR 989
Score = 48.9 bits (115), Expect = 3e-05
Identities = 26/57 (45%), Positives = 29/57 (50%), Gaps = 8/57 (14%)
Query: 16 GSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCY--SQRRDGGSSCVGPARS 70
G AP V WG W WS CSR+C GGV + RPC S R GG PAR+
Sbjct: 49 GGGAPGV------WGAWGPWSACSRSCSGGVMEQTRPCLPRSYRLRGGQRPGAPARA 99
Score = 43.5 bits (101), Expect = 0.001
Identities = 21/56 (37%), Positives = 27/56 (48%), Gaps = 1/56 (1%)
Query: 278 GFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPC 333
G W WS CS C GG + R V C D + ++C Q +P +R SCN C
Sbjct: 913 GAKWFSTEWSMCSKSCQGGFRVREVRCLSD-DMTLSNLCDPQLKPEERESCNPQDC 967
Score = 40.8 bits (94), Expect = 0.008
Identities = 17/42 (40%), Positives = 27/42 (64%), Gaps = 6/42 (14%)
Query: 1206 RDCVDQPE------LANCDLILQAQLCGNEYYSSFCCASCSR 1241
+DCV + + NC++++QA+LC YY + CCASC+R
Sbjct: 965 QDCVPEVDENCKDKYYNCNVVVQARLCVYNYYKTACCASCTR 1006
Score = 31.6 bits (70), Expect = 5.0
Identities = 15/49 (30%), Positives = 22/49 (44%), Gaps = 2/49 (4%)
Query: 33 SQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPAR--SHRSCRTESC 79
++WS CS++C GG RE C S + C + SC + C
Sbjct: 919 TEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDC 967
Score = 31.2 bits (69), Expect = 6.5
Identities = 25/82 (30%), Positives = 33/82 (40%), Gaps = 11/82 (13%)
Query: 35 WSPCSRTCGGGVSFRERPCYSQRRD-------GGSSCVGPARSHRSCRTESCPDGARDFR 87
WS CS CG G RE C + D S + S +SC + C GA+ F
Sbjct: 861 WSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPC--GAKWFS 918
Query: 88 AE--QCAEFDGAEFQGRRYRWL 107
E C++ F+ R R L
Sbjct: 919 TEWSMCSKSCQGGFRVREVRCL 940
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 225 bits (574), Expect = 2e-58
Identities = 157/485 (32%), Positives = 212/485 (43%), Gaps = 60/485 (12%)
Query: 20 PKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQR-RDGGSSCVGPARSHRSCRTES 78
P + ++ +WG WS + CSRTCG GV FR R C + +GG +C G A + C +
Sbjct: 555 PDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQD 614
Query: 79 CPDGARDFRAEQCAEFD-GAEFQGRRYRWLPYY--SAPNKCELNCIPKGENFYYKHREAV 135
CPD DFR EQC ++D E ++ WLP+ A +C L C + + V
Sbjct: 615 CPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMV 674
Query: 136 VDGTPCE-PGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTF----- 189
DGT C +CV G CR VGCD + SSKQEDKC CGGD + C V GTF
Sbjct: 675 HDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPK 734
Query: 190 ----------------------DANDLSRAVKNVR-GEYYLNGHWTIEAARALPAASTIL 226
DA AVKN+ G++ LN ++A+ A +
Sbjct: 735 KHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVE 794
Query: 227 HYERGAEGDLAPERLHARGPTSEPLVIELIS-QEPNPGVHYEYHL-----------PLRR 274
R +G E L GP + + +I + + Y+Y + L
Sbjct: 795 WEYRDEDG---RETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEE 851
Query: 275 PSPGFSWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQRQPRP-ADRRSCNLH 331
S + W+ WS CS CGGG Q C +DH+ C +P A RR+CN
Sbjct: 852 DSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQ 911
Query: 332 PCPETKRWKAGPWAPCSASCG-GGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQ 390
C + W G W PCS +CG G Q RSV CI +V C +P + +
Sbjct: 912 ECSQPV-WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN--DARPESRR 968
Query: 391 ACNLQRC-AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV 449
AC+ + C W PW +CSV+CG G ++R V CR S C E+RP C
Sbjct: 969 ACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSF---GICQ-EERPETARTCR 1024
Query: 450 HEDCP 454
CP
Sbjct: 1025 LGPCP 1029
Score = 94.0 bits (232), Expect = 8e-19
Identities = 62/181 (34%), Positives = 77/181 (42%), Gaps = 18/181 (9%)
Query: 339 WKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQ-ACNLQRC 397
W W+PCS CGGGSQ C + V CA L KP AI+ ACN Q C
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLD---HKMVHRGFCAAL-SKPKAIRRACNPQEC 913
Query: 398 A--AWSPEPWGECSVSCG-VGVRKRSVTC----RGERGSLLHTAACSLEDRPPLTEPCVH 450
+ W W CS +CG G++ RSV C +H C+ + RP C
Sbjct: 914 SQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN-DARPESRRACSR 972
Query: 451 EDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQP 510
E CP W G W CS +C +GT+ R V+C S G Q +P C P
Sbjct: 973 ELCP----GRWRAGPWSQCSVTCGNGTQERPVLCRTADDSF-GICQEERPETARTCRLGP 1027
Query: 511 C 511
C
Sbjct: 1028 C 1028
Score = 31.6 bits (70), Expect = 5.0
Identities = 23/92 (25%), Positives = 37/92 (40%), Gaps = 17/92 (18%)
Query: 455 LLSDQAWHVGTW---GLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPC 511
L D +W G W G CS++C +G + R C P++ G D + C+ Q C
Sbjct: 558 LKRDGSW--GAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDC 615
Query: 512 HLPQEVPSMQD----------VHTPASNPWMP 533
P + ++ H A + W+P
Sbjct: 616 --PDSLADFREEQCRQWDLYFEHGDAQHHWLP 645
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 215 bits (547), Expect = 2e-55
Identities = 158/503 (31%), Positives = 213/503 (42%), Gaps = 76/503 (15%)
Query: 25 QSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-GGSSCVGPARSHRSCRTESCPDGA 83
Q W W+++ CSR+CGGGV R R C + GG C+GP ++ C +E CP
Sbjct: 551 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 610
Query: 84 RDFRAEQCAEFDGAEF-QGRRYRWLPYYSAPN--KCELNCIPKGENFYYKHREAVVDGTP 140
DFRA+QCA+ + Q ++ W+PY + KCEL C + V DGT
Sbjct: 611 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTR 670
Query: 141 CEPGKRD---VCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTF-DANDLSR 196
C RD VC G C VGCD E+ S K +DKC CGGD + C V GT A+ +
Sbjct: 671 CS--YRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAG 728
Query: 197 AVK---------------------------NVRGEYYLNGHWTIEAARALPAASTILHYE 229
A+K V G + LN +R A L +E
Sbjct: 729 ALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMG--LEWE 786
Query: 230 RGAEGDLAPERLHARGPTSEPLVIELISQE---PNPGVHYEYHL------------PLRR 274
E A E L GP E + I + P + Y+Y + L
Sbjct: 787 DAVED--AKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLE 844
Query: 275 PSPGFSWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQRQPRPAD-RRSCNLH 331
+ W+ SW+ CS CGGG Q C DH H+C + RP RR CN H
Sbjct: 845 EMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQH 904
Query: 332 PCPETKRWKAGPWAPCSASCGG-GSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQ 390
PC + W W CS SCG G Q+R + C+ G + + CAG +P A +
Sbjct: 905 PCSQPV-WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG--DRPEARR 961
Query: 391 ACNLQRC-AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV 449
C C A W W +CS +CG G+++R V CR SL H DRP + C
Sbjct: 962 PCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEG----DRPDTVQVCS 1017
Query: 450 -------HEDCPLLSDQAWHVGT 465
H++ + +D W +GT
Sbjct: 1018 LPACGGNHQNSTVRAD-VWELGT 1039
Score = 40.0 bits (92), Expect = 0.014
Identities = 26/90 (28%), Positives = 37/90 (41%), Gaps = 9/90 (10%)
Query: 458 DQAWHVGT-WGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQE 516
D W T +G CS+SC G R R C P++ G L + + CN++ C E
Sbjct: 552 DGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYE 611
Query: 517 VPSMQD--------VHTPASNPWMPLGPQE 538
Q VH A + W+P P +
Sbjct: 612 DFRAQQCAKRNSYYVHQNAKHSWVPYEPDD 641
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 215 bits (547), Expect = 2e-55
Identities = 158/503 (31%), Positives = 213/503 (42%), Gaps = 76/503 (15%)
Query: 25 QSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-GGSSCVGPARSHRSCRTESCPDGA 83
Q W W+++ CSR+CGGGV R R C + GG C+GP ++ C +E CP
Sbjct: 554 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 613
Query: 84 RDFRAEQCAEFDGAEF-QGRRYRWLPYYSAPN--KCELNCIPKGENFYYKHREAVVDGTP 140
DFRA+QCA+ + Q ++ W+PY + KCEL C + V DGT
Sbjct: 614 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTR 673
Query: 141 CEPGKRD---VCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTF-DANDLSR 196
C RD VC G C VGCD E+ S K +DKC CGGD + C V GT A+ +
Sbjct: 674 CS--YRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAG 731
Query: 197 AVK---------------------------NVRGEYYLNGHWTIEAARALPAASTILHYE 229
A+K V G + LN +R A L +E
Sbjct: 732 ALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMG--LEWE 789
Query: 230 RGAEGDLAPERLHARGPTSEPLVIELISQE---PNPGVHYEYHL------------PLRR 274
E A E L GP E + I + P + Y+Y + L
Sbjct: 790 DAVED--AKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLE 847
Query: 275 PSPGFSWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQRQPRPAD-RRSCNLH 331
+ W+ SW+ CS CGGG Q C DH H+C + RP RR CN H
Sbjct: 848 EMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQH 907
Query: 332 PCPETKRWKAGPWAPCSASCGG-GSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQ 390
PC + W W CS SCG G Q+R + C+ G + + CAG +P A +
Sbjct: 908 PCSQPV-WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG--DRPEARR 964
Query: 391 ACNLQRC-AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV 449
C C A W W +CS +CG G+++R V CR SL H DRP + C
Sbjct: 965 PCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEG----DRPDTVQVCS 1020
Query: 450 -------HEDCPLLSDQAWHVGT 465
H++ + +D W +GT
Sbjct: 1021 LPACGGNHQNSTVRAD-VWELGT 1042
Score = 40.0 bits (92), Expect = 0.014
Identities = 26/90 (28%), Positives = 37/90 (41%), Gaps = 9/90 (10%)
Query: 458 DQAWHVGT-WGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQE 516
D W T +G CS+SC G R R C P++ G L + + CN++ C E
Sbjct: 555 DGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYE 614
Query: 517 VPSMQD--------VHTPASNPWMPLGPQE 538
Q VH A + W+P P +
Sbjct: 615 DFRAQQCAKRNSYYVHQNAKHSWVPYEPDD 644
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 200 bits (508), Expect = 8e-51
Identities = 170/573 (29%), Positives = 229/573 (39%), Gaps = 98/573 (17%)
Query: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-GGSSCVGPARSHRSCRTESCPDGARDFR 87
W W SPCSR+CGGGV R R C + R GG +CVG C T++C +F
Sbjct: 356 WSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFM 415
Query: 88 AEQCAEFDGAEFQGRR-----YRW---LPYYSAPNKCELNCIPKGENFYYKHREAVVDGT 139
++QCA DG + Y W +P+ C C GE+F K ++ +DGT
Sbjct: 416 SQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGT 475
Query: 140 PCEP------GKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDA-- 191
C P G +CV GSCR GCD +DS + D+C CGGD +TC P G+F A
Sbjct: 476 RCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGR 535
Query: 192 ------------NDLSRAVKNVR-----------GEYYLNGHWTIEAARALPA--ASTIL 226
N S + N R G Y + G +I P+ +
Sbjct: 536 AREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRV 595
Query: 227 HYERGAEGDLAP--ERLHARGPTSEPLVIELISQE-------PNPGVHYEYHLPLRRPSP 277
Y D P E + GP E I++ + P + + Y P +P
Sbjct: 596 EYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQP--KPRQ 653
Query: 278 GFSWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQ-RQPRPADRRSCNLHPCP 334
+ W+ CS CG G + C E CQ Q PA +C L PCP
Sbjct: 654 AWVWA-AVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCP 712
Query: 335 ETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAEC-AGLPGKPPAIQACN 393
W G + PCSASCGGG + R V C+ + G+ + + + A C AG A++ CN
Sbjct: 713 --PYWAVGDFGPCSASCGGGLRERPVRCVEAQGS-LLKTLPPARCRAGAQQPAVALETCN 769
Query: 394 LQRC-AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSL---LHTAACSLEDRPPLTEPCV 449
Q C A W C+ + G G+ + TC L + S++++ P EPCV
Sbjct: 770 PQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCV 829
Query: 450 HEDCP----------------------LLSDQAWHVGT--WGLCSKSCSSGTRRRQVIC- 484
CP QA HV T G CS SC G + +C
Sbjct: 830 GMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCM 889
Query: 485 --AIGPPSH---CGSLQHSKPVD-VEPCNTQPC 511
A+ P CG SKP E C PC
Sbjct: 890 DSALRVPVQEELCGLA--SKPGSRREVCQAVPC 920
Score = 125 bits (315), Expect = 2e-28
Identities = 87/244 (35%), Positives = 116/244 (47%), Gaps = 23/244 (9%)
Query: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDHEAYP--DHMCQRQPRPADRRS-CNLHPCPETK 337
W+ + S CS CG G C P + +C +P RR C PCP
Sbjct: 866 WTPAAGS-CSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARW 924
Query: 338 RWKAGPWAPCSASCGGGSQSRSVYCISSDGAGI-QEAVEEAECAGLPGKPPAIQACNLQR 396
++K A CS SCG G R +YC + G +E + + +C GLP +P +AC+L+
Sbjct: 925 QYKL---AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLP-RPEPQEACSLEP 980
Query: 397 CAA-WSPEPWGECSVSCGVGVRKRSVTC-RGERGSLLHT--AACSLEDRPPLTEPCVHED 452
C W G CS SCG+G +RSV C + ++G + AAC+ RP + PC+ D
Sbjct: 981 CPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIAD 1040
Query: 453 CPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGP----PSHCGSLQH-SKPVDVEPCN 507
C WHVGTW CS SC G +RR+ C +GP P QH KPV V C
Sbjct: 1041 CTY----RWHVGTWMECSVSCGDGIQRRRDTC-LGPQAQAPVPADFCQHLPKPVTVRGCW 1095
Query: 508 TQPC 511
PC
Sbjct: 1096 AGPC 1099
Score = 110 bits (276), Expect = 6e-24
Identities = 114/413 (27%), Positives = 150/413 (36%), Gaps = 84/413 (20%)
Query: 35 WSPCSRTCGGGVSFRERPCYSQRRDGG-----------SSCVGPARSHRSCRTESCPDGA 83
+ PCS +CGGG+ RERP G + PA + +C + CP
Sbjct: 720 FGPCSASCGGGL--RERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARW 777
Query: 84 RDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEP 143
C GA + N+ C+P + V +G P
Sbjct: 778 EVSEPSSCTSAGGAGL-----------ALENE---TCVPGADGL----EAPVTEG----P 815
Query: 144 GKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDLSRAVKNVRG 203
G D + + C+ G +C P G DA + G
Sbjct: 816 GSVD----------------EKLPAPEPCV-----GMSCPPGWGHLDATSAGEKAPSPWG 854
Query: 204 EYYLNGH----WTIEAARALPAASTILHYERGAEGDLAPERLHARGPTSEPLVIELISQE 259
WT A + L R D A R P E EL
Sbjct: 855 SIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSA-----LRVPVQE----ELCGLA 905
Query: 260 PNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDH------EAYPD 313
PG E + P+ W + + CS CG G R+++C H E D
Sbjct: 906 SKPGSRREVCQAVPCPA---RWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLD 961
Query: 314 HMCQRQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEA 373
CQ PRP + +C+L PCP RWK PCSASCG G+ RSV C+ D G
Sbjct: 962 TQCQGLPRPEPQEACSLEPCPP--RWKVMSLGPCSASCGLGTARRSVACVQLD-QGQDVE 1018
Query: 374 VEEAECAGLPGKPPAIQACNLQRCA-AWSPEPWGECSVSCGVGVRKRSVTCRG 425
V+EA CA L +P A C + C W W ECSVSCG G+++R TC G
Sbjct: 1019 VDEAACAALV-RPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLG 1070
Score = 77.4 bits (189), Expect = 8e-14
Identities = 49/133 (36%), Positives = 62/133 (46%), Gaps = 20/133 (15%)
Query: 406 GECSVSCGVGVRKRSVTCRGE-RGSLLHTAACSLEDRPPL-TEPCVHEDCPLLSDQAWHV 463
G CSVSCG G+R + +C + R L+ T C +PP E CV E CP W V
Sbjct: 662 GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCP----PYWAV 717
Query: 464 GTWGLCSKSCSSGTRRRQVICAIG--------PPSHCGSLQHSKPVDVEPCNTQPCHLPQ 515
G +G CS SC G R R V C PP+ C + V +E CN QPC
Sbjct: 718 GDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPC---- 773
Query: 516 EVPSMQDVHTPAS 528
P+ +V P+S
Sbjct: 774 --PARWEVSEPSS 784
Score = 38.1 bits (87), Expect = 0.053
Identities = 37/102 (36%), Positives = 44/102 (43%), Gaps = 16/102 (15%)
Query: 465 TWGL---CSKSCSSG--TRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQ-EVP 518
+WG CS+SC G TRRRQ C P+ G + E CNTQ C Q E
Sbjct: 358 SWGPRSPCSRSCGGGVVTRRRQ--CNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFM 415
Query: 519 SMQDVHTPASNPWMPLGPQESPASDSRGQWWAAQEHPSARGD 560
S Q T PL + SP S W AA H ++GD
Sbjct: 416 SQQCARTDG----QPL--RSSPGGASFYHWGAAVPH--SQGD 449
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 200 bits (508), Expect = 8e-51
Identities = 170/573 (29%), Positives = 229/573 (39%), Gaps = 98/573 (17%)
Query: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-GGSSCVGPARSHRSCRTESCPDGARDFR 87
W W SPCSR+CGGGV R R C + R GG +CVG C T++C +F
Sbjct: 387 WSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFM 446
Query: 88 AEQCAEFDGAEFQGRR-----YRW---LPYYSAPNKCELNCIPKGENFYYKHREAVVDGT 139
++QCA DG + Y W +P+ C C GE+F K ++ +DGT
Sbjct: 447 SQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGT 506
Query: 140 PCEP------GKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDA-- 191
C P G +CV GSCR GCD +DS + D+C CGGD +TC P G+F A
Sbjct: 507 RCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGR 566
Query: 192 ------------NDLSRAVKNVR-----------GEYYLNGHWTIEAARALPA--ASTIL 226
N S + N R G Y + G +I P+ +
Sbjct: 567 AREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRV 626
Query: 227 HYERGAEGDLAP--ERLHARGPTSEPLVIELISQE-------PNPGVHYEYHLPLRRPSP 277
Y D P E + GP E I++ + P + + Y P +P
Sbjct: 627 EYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQP--KPRQ 684
Query: 278 GFSWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQ-RQPRPADRRSCNLHPCP 334
+ W+ CS CG G + C E CQ Q PA +C L PCP
Sbjct: 685 AWVWA-AVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCP 743
Query: 335 ETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAEC-AGLPGKPPAIQACN 393
W G + PCSASCGGG + R V C+ + G+ + + + A C AG A++ CN
Sbjct: 744 --PYWAVGDFGPCSASCGGGLRERPVRCVEAQGS-LLKTLPPARCRAGAQQPAVALETCN 800
Query: 394 LQRC-AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSL---LHTAACSLEDRPPLTEPCV 449
Q C A W C+ + G G+ + TC L + S++++ P EPCV
Sbjct: 801 PQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCV 860
Query: 450 HEDCP----------------------LLSDQAWHVGT--WGLCSKSCSSGTRRRQVIC- 484
CP QA HV T G CS SC G + +C
Sbjct: 861 GMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCM 920
Query: 485 --AIGPPSH---CGSLQHSKPVD-VEPCNTQPC 511
A+ P CG SKP E C PC
Sbjct: 921 DSALRVPVQEELCGLA--SKPGSRREVCQAVPC 951
Score = 125 bits (315), Expect = 2e-28
Identities = 87/244 (35%), Positives = 116/244 (47%), Gaps = 23/244 (9%)
Query: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDHEAYP--DHMCQRQPRPADRRS-CNLHPCPETK 337
W+ + S CS CG G C P + +C +P RR C PCP
Sbjct: 897 WTPAAGS-CSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARW 955
Query: 338 RWKAGPWAPCSASCGGGSQSRSVYCISSDGAGI-QEAVEEAECAGLPGKPPAIQACNLQR 396
++K A CS SCG G R +YC + G +E + + +C GLP +P +AC+L+
Sbjct: 956 QYKL---AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLP-RPEPQEACSLEP 1011
Query: 397 CAA-WSPEPWGECSVSCGVGVRKRSVTC-RGERGSLLHT--AACSLEDRPPLTEPCVHED 452
C W G CS SCG+G +RSV C + ++G + AAC+ RP + PC+ D
Sbjct: 1012 CPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIAD 1071
Query: 453 CPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGP----PSHCGSLQH-SKPVDVEPCN 507
C WHVGTW CS SC G +RR+ C +GP P QH KPV V C
Sbjct: 1072 CTY----RWHVGTWMECSVSCGDGIQRRRDTC-LGPQAQAPVPADFCQHLPKPVTVRGCW 1126
Query: 508 TQPC 511
PC
Sbjct: 1127 AGPC 1130
Score = 110 bits (276), Expect = 6e-24
Identities = 114/413 (27%), Positives = 150/413 (36%), Gaps = 84/413 (20%)
Query: 35 WSPCSRTCGGGVSFRERPCYSQRRDGG-----------SSCVGPARSHRSCRTESCPDGA 83
+ PCS +CGGG+ RERP G + PA + +C + CP
Sbjct: 751 FGPCSASCGGGL--RERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARW 808
Query: 84 RDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEP 143
C GA + N+ C+P + V +G P
Sbjct: 809 EVSEPSSCTSAGGAGL-----------ALENE---TCVPGADGL----EAPVTEG----P 846
Query: 144 GKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDLSRAVKNVRG 203
G D + + C+ G +C P G DA + G
Sbjct: 847 GSVD----------------EKLPAPEPCV-----GMSCPPGWGHLDATSAGEKAPSPWG 885
Query: 204 EYYLNGH----WTIEAARALPAASTILHYERGAEGDLAPERLHARGPTSEPLVIELISQE 259
WT A + L R D A R P E EL
Sbjct: 886 SIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSA-----LRVPVQE----ELCGLA 936
Query: 260 PNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDH------EAYPD 313
PG E + P+ W + + CS CG G R+++C H E D
Sbjct: 937 SKPGSRREVCQAVPCPA---RWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLD 992
Query: 314 HMCQRQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEA 373
CQ PRP + +C+L PCP RWK PCSASCG G+ RSV C+ D G
Sbjct: 993 TQCQGLPRPEPQEACSLEPCPP--RWKVMSLGPCSASCGLGTARRSVACVQLD-QGQDVE 1049
Query: 374 VEEAECAGLPGKPPAIQACNLQRCA-AWSPEPWGECSVSCGVGVRKRSVTCRG 425
V+EA CA L +P A C + C W W ECSVSCG G+++R TC G
Sbjct: 1050 VDEAACAALV-RPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLG 1101
Score = 77.4 bits (189), Expect = 8e-14
Identities = 49/133 (36%), Positives = 62/133 (46%), Gaps = 20/133 (15%)
Query: 406 GECSVSCGVGVRKRSVTCRGE-RGSLLHTAACSLEDRPPL-TEPCVHEDCPLLSDQAWHV 463
G CSVSCG G+R + +C + R L+ T C +PP E CV E CP W V
Sbjct: 693 GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCP----PYWAV 748
Query: 464 GTWGLCSKSCSSGTRRRQVICAIG--------PPSHCGSLQHSKPVDVEPCNTQPCHLPQ 515
G +G CS SC G R R V C PP+ C + V +E CN QPC
Sbjct: 749 GDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPC---- 804
Query: 516 EVPSMQDVHTPAS 528
P+ +V P+S
Sbjct: 805 --PARWEVSEPSS 815
Score = 38.1 bits (87), Expect = 0.053
Identities = 37/102 (36%), Positives = 44/102 (43%), Gaps = 16/102 (15%)
Query: 465 TWGL---CSKSCSSG--TRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQ-EVP 518
+WG CS+SC G TRRRQ C P+ G + E CNTQ C Q E
Sbjct: 389 SWGPRSPCSRSCGGGVVTRRRQ--CNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFM 446
Query: 519 SMQDVHTPASNPWMPLGPQESPASDSRGQWWAAQEHPSARGD 560
S Q T PL + SP S W AA H ++GD
Sbjct: 447 SQQCARTDG----QPL--RSSPGGASFYHWGAAVPH--SQGD 480
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 200 bits (508), Expect = 8e-51
Identities = 170/573 (29%), Positives = 229/573 (39%), Gaps = 98/573 (17%)
Query: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-GGSSCVGPARSHRSCRTESCPDGARDFR 87
W W SPCSR+CGGGV R R C + R GG +CVG C T++C +F
Sbjct: 387 WSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFM 446
Query: 88 AEQCAEFDGAEFQGRR-----YRW---LPYYSAPNKCELNCIPKGENFYYKHREAVVDGT 139
++QCA DG + Y W +P+ C C GE+F K ++ +DGT
Sbjct: 447 SQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGT 506
Query: 140 PCEP------GKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDA-- 191
C P G +CV GSCR GCD +DS + D+C CGGD +TC P G+F A
Sbjct: 507 RCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGR 566
Query: 192 ------------NDLSRAVKNVR-----------GEYYLNGHWTIEAARALPA--ASTIL 226
N S + N R G Y + G +I P+ +
Sbjct: 567 AREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRV 626
Query: 227 HYERGAEGDLAP--ERLHARGPTSEPLVIELISQE-------PNPGVHYEYHLPLRRPSP 277
Y D P E + GP E I++ + P + + Y P +P
Sbjct: 627 EYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQP--KPRQ 684
Query: 278 GFSWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQ-RQPRPADRRSCNLHPCP 334
+ W+ CS CG G + C E CQ Q PA +C L PCP
Sbjct: 685 AWVWA-AVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCP 743
Query: 335 ETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAEC-AGLPGKPPAIQACN 393
W G + PCSASCGGG + R V C+ + G+ + + + A C AG A++ CN
Sbjct: 744 --PYWAVGDFGPCSASCGGGLRERPVRCVEAQGS-LLKTLPPARCRAGAQQPAVALETCN 800
Query: 394 LQRC-AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSL---LHTAACSLEDRPPLTEPCV 449
Q C A W C+ + G G+ + TC L + S++++ P EPCV
Sbjct: 801 PQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCV 860
Query: 450 HEDCP----------------------LLSDQAWHVGT--WGLCSKSCSSGTRRRQVIC- 484
CP QA HV T G CS SC G + +C
Sbjct: 861 GMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCM 920
Query: 485 --AIGPPSH---CGSLQHSKPVD-VEPCNTQPC 511
A+ P CG SKP E C PC
Sbjct: 921 DSALRVPVQEELCGLA--SKPGSRREVCQAVPC 951
Score = 127 bits (319), Expect = 7e-29
Identities = 93/263 (35%), Positives = 125/263 (47%), Gaps = 25/263 (9%)
Query: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDHEAYP--DHMCQRQPRPADRRS-CNLHPCPETK 337
W+ + S CS CG G C P + +C +P RR C PCP
Sbjct: 897 WTPAAGS-CSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARW 955
Query: 338 RWKAGPWAPCSASCGGGSQSRSVYCISSDGAGI-QEAVEEAECAGLPGKPPAIQACNLQR 396
++K A CS SCG G R +YC + G +E + + +C GLP +P +AC+L+
Sbjct: 956 QYKL---AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLP-RPEPQEACSLEP 1011
Query: 397 CAA-WSPEPWGECSVSCGVGVRKRSVTC-RGERGSLLHT--AACSLEDRPPLTEPCVHED 452
C W G CS SCG+G +RSV C + ++G + AAC+ RP + PC+ D
Sbjct: 1012 CPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIAD 1071
Query: 453 CPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGP----PSHCGSLQH-SKPVDVEPCN 507
C WHVGTW CS SC G +RR+ C +GP P QH KPV V C
Sbjct: 1072 CTY----RWHVGTWMECSVSCGDGIQRRRDTC-LGPQAQAPVPADFCQHLPKPVTVRGCW 1126
Query: 508 TQPCHLPQEVPSMQDVHTPASNP 530
PC + Q PS+ H A+ P
Sbjct: 1127 AGPC-VGQGTPSLVP-HEEAAAP 1147
Score = 112 bits (279), Expect = 3e-24
Identities = 122/450 (27%), Positives = 161/450 (35%), Gaps = 90/450 (20%)
Query: 35 WSPCSRTCGGGVSFRERPCYSQRRDGG-----------SSCVGPARSHRSCRTESCPDGA 83
+ PCS +CGGG+ RERP G + PA + +C + CP
Sbjct: 751 FGPCSASCGGGL--RERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARW 808
Query: 84 RDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEP 143
C GA + N+ C+P + V +G P
Sbjct: 809 EVSEPSSCTSAGGAGL-----------ALENE---TCVPGADGL----EAPVTEG----P 846
Query: 144 GKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDLSRAVKNVRG 203
G D + + C+ G +C P G DA + G
Sbjct: 847 GSVD----------------EKLPAPEPCV-----GMSCPPGWGHLDATSAGEKAPSPWG 885
Query: 204 EYYLNGH----WTIEAARALPAASTILHYERGAEGDLAPERLHARGPTSEPLVIELISQE 259
WT A + L R D A R P E EL
Sbjct: 886 SIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSA-----LRVPVQE----ELCGLA 936
Query: 260 PNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDH------EAYPD 313
PG E + P+ W + + CS CG G R+++C H E D
Sbjct: 937 SKPGSRREVCQAVPCPA---RWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLD 992
Query: 314 HMCQRQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEA 373
CQ PRP + +C+L PCP RWK PCSASCG G+ RSV C+ D G
Sbjct: 993 TQCQGLPRPEPQEACSLEPCPP--RWKVMSLGPCSASCGLGTARRSVACVQLD-QGQDVE 1049
Query: 374 VEEAECAGLPGKPPAIQACNLQRCA-AWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLH 432
V+EA CA L +P A C + C W W ECSVSCG G+++R TC G +
Sbjct: 1050 VDEAACAALV-RPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPV 1108
Query: 433 TAACSLEDRPPLT------EPCVHEDCPLL 456
A P+T PCV + P L
Sbjct: 1109 PADFCQHLPKPVTVRGCWAGPCVGQGTPSL 1138
Score = 77.4 bits (189), Expect = 8e-14
Identities = 49/133 (36%), Positives = 62/133 (46%), Gaps = 20/133 (15%)
Query: 406 GECSVSCGVGVRKRSVTCRGE-RGSLLHTAACSLEDRPPL-TEPCVHEDCPLLSDQAWHV 463
G CSVSCG G+R + +C + R L+ T C +PP E CV E CP W V
Sbjct: 693 GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCP----PYWAV 748
Query: 464 GTWGLCSKSCSSGTRRRQVICAIG--------PPSHCGSLQHSKPVDVEPCNTQPCHLPQ 515
G +G CS SC G R R V C PP+ C + V +E CN QPC
Sbjct: 749 GDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPC---- 804
Query: 516 EVPSMQDVHTPAS 528
P+ +V P+S
Sbjct: 805 --PARWEVSEPSS 815
Score = 38.1 bits (87), Expect = 0.053
Identities = 37/102 (36%), Positives = 44/102 (43%), Gaps = 16/102 (15%)
Query: 465 TWGL---CSKSCSSG--TRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQ-EVP 518
+WG CS+SC G TRRRQ C P+ G + E CNTQ C Q E
Sbjct: 389 SWGPRSPCSRSCGGGVVTRRRQ--CNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFM 446
Query: 519 SMQDVHTPASNPWMPLGPQESPASDSRGQWWAAQEHPSARGD 560
S Q T PL + SP S W AA H ++GD
Sbjct: 447 SQQCARTDG----QPL--RSSPGGASFYHWGAAVPH--SQGD 480
>gi|226442878 ADAMTS-like 5 [Homo sapiens]
Length = 471
Score = 198 bits (503), Expect = 3e-50
Identities = 115/303 (37%), Positives = 154/303 (50%), Gaps = 39/303 (12%)
Query: 3 LLLLVPLLLAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGS 62
LLL + LL G SA + W PW W+ CS +CG GVS R R C R G
Sbjct: 16 LLLFLWALLNCGLGVSA----QGPGEWTPWVSWTRCSSSCGRGVSVRSRRCL--RLPGEE 69
Query: 63 SCVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQG--RRYRWLPYYSAPNKCELNC 120
C G + +R C+ CP GA FR QCA ++G G + Y+W+P++ APN+C+LNC
Sbjct: 70 PCWGDSHEYRLCQLPDCPPGAVPFRDLQCALYNGRPVLGTQKTYQWVPFHGAPNQCDLNC 129
Query: 121 IPKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGT 180
+ +G FY+ V+DGT C PG + VCV G C GCD L S ED+C RCGG
Sbjct: 130 LAEGHAFYHSFGR-VLDGTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGAND 188
Query: 181 TCYPV----------AGTFDANDLSRAVKNVR---------------GEYYLNGHWTIEA 215
+C V AG ++ + +++R G Y LNGHW +
Sbjct: 189 SCLFVQRVFRDAGAFAGYWNVTLIPEGARHIRVEHRSRNHLALMGGDGRYVLNGHWVVSP 248
Query: 216 ARALPAASTILHYERGAEGDLAP-ERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRR 274
AA T + Y R D P E L A GPTS L+++++ QEPNPG+ +E+ LP R
Sbjct: 249 PGTYEAAGTHVVYTR----DTGPQETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWLPRER 304
Query: 275 PSP 277
SP
Sbjct: 305 YSP 307
Score = 32.3 bits (72), Expect = 2.9
Identities = 24/63 (38%), Positives = 25/63 (39%), Gaps = 7/63 (11%)
Query: 400 WSP-EPWGECSVSCGVGVRKRSVTC---RGER---GSLLHTAACSLEDRPPLTEPCVHED 452
W+P W CS SCG GV RS C GE G C L D PP P
Sbjct: 38 WTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLPDCPPGAVPFRDLQ 97
Query: 453 CPL 455
C L
Sbjct: 98 CAL 100
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 188 bits (477), Expect = 3e-47
Identities = 115/365 (31%), Positives = 164/365 (44%), Gaps = 64/365 (17%)
Query: 29 WGPWSQWSPCSRTCGGGVSFRERPCYS-QRRDGGSSCVGPARSHRSCRTESCPDGARDFR 87
W PW W CSRTCGGGV F R C + ++GG C+G ++SC TE CP + FR
Sbjct: 529 WAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFR 588
Query: 88 AEQCAEFDG---AEFQGRRYRWLPYY---SAPNKCELNCIPKGENFYYKHREAVVDGTPC 141
+QC +++ + G +W+P Y S ++C+L C +G + + V+DGT C
Sbjct: 589 EQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLC 648
Query: 142 EPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGT-----FDANDLSR 196
P +CV G C GCDH +DS ++ DKC CGG G +C V+G+ + ND+
Sbjct: 649 GPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVT 708
Query: 197 -------------------------AVKNVRGEYYLNGHWTIEAARA-LPAASTILHYER 230
A+K G+Y LNG+ I A + TIL Y
Sbjct: 709 IPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYS- 767
Query: 231 GAEGDLAP-ERLHARGPTSEPLVIELISQEPN---PGVHYEYHLP--------------- 271
G +A ERL + P EPL ++L++ P V Y + +P
Sbjct: 768 ---GSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKERAT 824
Query: 272 --LRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCN 329
+ +P W G WS+CS+ CG G Q R V C D C + +P D + C
Sbjct: 825 TNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECR-DPSGQASATCNKALKPEDAKPCE 883
Query: 330 LHPCP 334
CP
Sbjct: 884 SQLCP 888
Score = 47.4 bits (111), Expect = 9e-05
Identities = 22/58 (37%), Positives = 31/58 (53%), Gaps = 2/58 (3%)
Query: 398 AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPL 455
A W W ECS +CG G ++R+V CR G +A C+ +P +PC + CPL
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQA--SATCNKALKPEDAKPCESQLCPL 889
Score = 42.7 bits (99), Expect = 0.002
Identities = 26/63 (41%), Positives = 33/63 (52%), Gaps = 6/63 (9%)
Query: 454 PLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSL---QHSKPVDVEPCNTQP 510
PLL Q W +G W CS +C +G +RR V C PS S + KP D +PC +Q
Sbjct: 830 PLLHAQ-WVLGDWSECSSTCGAGWQRRTVECR--DPSGQASATCNKALKPEDAKPCESQL 886
Query: 511 CHL 513
C L
Sbjct: 887 CPL 889
Score = 33.1 bits (74), Expect = 1.7
Identities = 45/188 (23%), Positives = 65/188 (34%), Gaps = 30/188 (15%)
Query: 343 PWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLP---GKPPAIQACNL-QRCA 398
PW+PCSA +Y G + + +A A LP G P + L Q+C
Sbjct: 404 PWSPCSA----------MYLTELLDGGHGDCLLDAPAAALPLPTGLPGRMALYQLDQQCR 453
Query: 399 AWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLE--DRPP------------L 444
+ C + V + L HT SL D P L
Sbjct: 454 QIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCL 513
Query: 445 TEPCVHEDCPLLSDQAWHV-GTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDV 503
E V P+ +D W G WG CS++C G + C P + G +
Sbjct: 514 PEEEVERPKPV-ADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKY 572
Query: 504 EPCNTQPC 511
+ C+T+ C
Sbjct: 573 QSCHTEEC 580
Score = 32.7 bits (73), Expect = 2.2
Identities = 21/54 (38%), Positives = 27/54 (50%), Gaps = 10/54 (18%)
Query: 400 WSP-EPWGECSVSCGVGVRKRSVTCR------GERGSLLHTA---ACSLEDRPP 443
W+P PWGECS +CG GV+ C+ G R L A +C E+ PP
Sbjct: 529 WAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPP 582
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 162 bits (409), Expect = 2e-39
Identities = 119/413 (28%), Positives = 169/413 (40%), Gaps = 96/413 (23%)
Query: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQR-RDGGSSCVGPARSHRSCRTESCPDGARDFR 87
WG W W CSR+CGGGV F R C + R+ G C G +RSC CP + FR
Sbjct: 570 WGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFR 629
Query: 88 AEQCAEFDGAEFQGRRYR----WLPYYSA---PNKCELNCIPKGENFYYKHREAVVDGTP 140
EQC +G + + + W+P Y+ + C+L C KG +Y V DGT
Sbjct: 630 HEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTE 689
Query: 141 CEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFD---------- 190
C VCV G C GCD + S Q DKC CGGD ++C + GTF+
Sbjct: 690 CRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSKGYTDVV 749
Query: 191 ---------------ANDLSR-----AVKNVRGEYYLNGHWTIEAARAL-PAASTILHYE 229
A D +R A+K GEY +NG + I + + T+++Y
Sbjct: 750 RIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYS 809
Query: 230 RGAEGDLAPERLHARG--PTSEPLVIELISQEPNP--GVHYEYHLPLRR-PSPGFSWSHG 284
+ D + LH G T E L++++++ +P V Y + +P + P SHG
Sbjct: 810 GWSHRD---DFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHG 866
Query: 285 SWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRWKAGPW 344
S G H S QP+ W GPW
Sbjct: 867 S------NKVGSHTS-------------------QPQ-----------------WVTGPW 884
Query: 345 APCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397
CS +C G +R+V C DG + A+ L +P A + C L++C
Sbjct: 885 LACSRTCDTGWHTRTVQC--QDGNR-----KLAKGCPLSQRPSAFKQCLLKKC 930
Score = 35.4 bits (80), Expect = 0.34
Identities = 17/54 (31%), Positives = 24/54 (44%), Gaps = 2/54 (3%)
Query: 400 WSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDC 453
W PW CS +C G R+V C + G+ C L RP + C+ + C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQC--QDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 34.3 bits (77), Expect = 0.77
Identities = 36/138 (26%), Positives = 52/138 (37%), Gaps = 10/138 (7%)
Query: 382 LPGKP-PAIQACNLQRCAAWSPEPWGECSVS--CGVGVRKRSVTCRGERGSLLHTAACSL 438
LPG+ A Q CNL +S P + C V VR+ + C ++ + C
Sbjct: 486 LPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAV-VRQGQMVCLTKKLPAVEGTPCG- 543
Query: 439 EDRPPLTEPCVHEDCPLLSDQAWHV-----GTWGLCSKSCSSGTRRRQVICAIGPPSHCG 493
+ R L CV + + H G+WG CS+SC G + C P + G
Sbjct: 544 KGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNG 603
Query: 494 SLQHSKPVDVEPCNTQPC 511
K C+ PC
Sbjct: 604 RYCTGKRAIYRSCSLMPC 621
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 161 bits (408), Expect = 3e-39
Identities = 100/293 (34%), Positives = 135/293 (46%), Gaps = 44/293 (15%)
Query: 25 QSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQ-RRDGGSSCVGPARSHRSCRTESCPDG- 82
Q+ WGPW W CSRTCGGGV F R C R+GG C G RSC TE CP G
Sbjct: 519 QAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGS 578
Query: 83 ARDFRAEQCAEFDGAEFQGRRYR----WLPYYS--AP-NKCELNCIPKGENFYYKHREAV 135
A FR EQCA ++ + + W+P Y+ AP ++C+L C + +YY V
Sbjct: 579 ALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRV 638
Query: 136 VDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTF------ 189
VDGTPC P VCV G C GCD + S K+ DKC+ CGGDG+ C +G+F
Sbjct: 639 VDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYG 698
Query: 190 ----------------------DANDLSRAVKNVRGEYYLNGHWTIEAAR---ALPAAST 224
+ A+K G Y LNG +T+ + LP A +
Sbjct: 699 YNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVS 758
Query: 225 ILHYERGAEGDLAPERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSP 277
+ R + A E L GP ++PL ++++ Y + RP+P
Sbjct: 759 L----RYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPRPTP 807
Score = 47.4 bits (111), Expect = 9e-05
Identities = 52/188 (27%), Positives = 71/188 (37%), Gaps = 35/188 (18%)
Query: 286 WSDCSA-------ECGGGHQSRLVFCTIDHEAYPDHMCQRQPRP---ADRRSCNL----- 330
WS CSA + G GH C +D P H+ P ADR+ C L
Sbjct: 404 WSPCSARFITDFLDNGYGH------CLLDKPEAPLHLPVTFPGKDYDADRQ-CQLTFGPD 456
Query: 331 -HPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGA--GIQEAVEEAECAGLPGKPP 387
CP+ A W CS G + ++ + +DG G +A C +
Sbjct: 457 SRHCPQLPPPCAALW--CSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMD---- 510
Query: 388 AIQACNLQRCAAWSP-EPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTE 446
+Q N+ + W P PWG+CS +CG GV+ S C + E R
Sbjct: 511 QLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDC---TRPVPRNGGKYCEGRRTRFR 567
Query: 447 PCVHEDCP 454
C EDCP
Sbjct: 568 SCNTEDCP 575
Score = 37.7 bits (86), Expect = 0.069
Identities = 37/144 (25%), Positives = 44/144 (30%), Gaps = 25/144 (17%)
Query: 275 PSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCP 334
P G G W DCS CGGG Q CT C + R RSCN CP
Sbjct: 518 PQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYC--EGRRTRFRSCNTEDCP 575
Query: 335 -----------------ETKRWKAGP----WAPCSASCGGGSQSRSVYCISSDGAGIQEA 373
T +K+ P W P G Q + + G
Sbjct: 576 TGSALTFREEQCAAYNHRTDLFKSFPGPMDWVP--RYTGVAPQDQCKLTCQAQALGYYYV 633
Query: 374 VEEAECAGLPGKPPAIQACNLQRC 397
+E G P P + C RC
Sbjct: 634 LEPRVVDGTPCSPDSSSVCVQGRC 657
Score = 33.1 bits (74), Expect = 1.7
Identities = 14/48 (29%), Positives = 20/48 (41%)
Query: 464 GTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPC 511
G WG CS++C G + C P + G + CNT+ C
Sbjct: 527 GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDC 574
Score = 32.7 bits (73), Expect = 2.2
Identities = 31/124 (25%), Positives = 43/124 (34%), Gaps = 23/124 (18%)
Query: 289 CSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHP-------CPETKRWKA 341
C+A GH + C H + D + C LH P+ W
Sbjct: 467 CAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC-LHMDQLQDFNIPQAGGWGP 525
Query: 342 -GPWAPCSASCGGGSQSRSVYC---ISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397
GPW CS +CGGG Q S C + +G E G+ ++CN + C
Sbjct: 526 WGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCE-----------GRRTRFRSCNTEDC 574
Query: 398 AAWS 401
S
Sbjct: 575 PTGS 578
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.449
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,930,361
Number of Sequences: 37866
Number of extensions: 4003659
Number of successful extensions: 20560
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 233
Number of HSP's successfully gapped in prelim test: 463
Number of HSP's that attempted gapping in prelim test: 13891
Number of HSP's gapped (non-prelim): 4567
length of query: 1251
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1137
effective length of database: 13,930,794
effective search space: 15839312778
effective search space used: 15839312778
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.