Search of human proteins with 145309326

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|145309326 laminin, gamma 1 precursor [Homo sapiens]
         (1609 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|145309326 laminin, gamma 1 precursor [Homo sapiens]               3359   0.0  
gi|110611156 laminin, gamma 3 precursor [Homo sapiens]               1384   0.0  
gi|157419140 laminin, gamma 2 isoform b precursor [Homo sapiens]      709   0.0  
gi|157419138 laminin, gamma 2 isoform a precursor [Homo sapiens]      709   0.0  
gi|38788416 laminin, alpha 1 precursor [Homo sapiens]                 623   e-178
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s...   620   e-177
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa...   620   e-177
gi|148613884 netrin 1 [Homo sapiens]                                  443   e-124
gi|21264602 laminin alpha 5 [Homo sapiens]                            402   e-111
gi|167614504 laminin, beta 1 precursor [Homo sapiens]                 340   7e-93
gi|5453810 netrin 3 [Homo sapiens]                                    327   7e-89
gi|143770880 laminin, beta 4 [Homo sapiens]                           312   1e-84
gi|119703755 laminin, beta 2 precursor [Homo sapiens]                 306   1e-82
gi|38045910 laminin alpha 3 subunit isoform 1 [Homo sapiens]          285   3e-76
gi|189217425 laminin alpha 3 subunit isoform 3 [Homo sapiens]         285   3e-76
gi|62868217 laminin, beta 3 precursor [Homo sapiens]                  276   9e-74
gi|62868215 laminin, beta 3 precursor [Homo sapiens]                  276   9e-74
gi|189083719 laminin, beta 3 precursor [Homo sapiens]                 276   9e-74
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]            269   1e-71
gi|219842266 usherin isoform B [Homo sapiens]                         245   2e-64
gi|219842259 usherin isoform A [Homo sapiens]                         245   2e-64
gi|93204871 netrin 4 [Homo sapiens]                                   245   2e-64
gi|164414431 netrin G1 isoform 1 [Homo sapiens]                       224   4e-58
gi|190014607 netrin G2 [Homo sapiens]                                 209   2e-53
gi|157419124 laminin, alpha 4 isoform 1 precursor [Homo sapiens]      157   8e-38
gi|157419126 laminin, alpha 4 isoform 2 precursor [Homo sapiens]      156   1e-37
gi|157419122 laminin, alpha 4 isoform 2 precursor [Homo sapiens]      156   1e-37
gi|24308065 netrin 5 [Homo sapiens]                                   150   1e-35
gi|54312078 netrin G1 isoform 3 [Homo sapiens]                        145   2e-34
gi|164414437 netrin G1 isoform 2 [Homo sapiens]                       140   1e-32

>gi|145309326 laminin, gamma 1 precursor [Homo sapiens]
          Length = 1609

 Score = 3359 bits (8710), Expect = 0.0
 Identities = 1609/1609 (100%), Positives = 1609/1609 (100%)

Query: 1    MRGSHRAAPALRPRGRLWPVLAVLAAAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFN 60
            MRGSHRAAPALRPRGRLWPVLAVLAAAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFN
Sbjct: 1    MRGSHRAAPALRPRGRLWPVLAVLAAAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFN 60

Query: 61   VTVVATNTCGTPPEEYCVQTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQS 120
            VTVVATNTCGTPPEEYCVQTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQS
Sbjct: 61   VTVVATNTCGTPPEEYCVQTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQS 120

Query: 121  QTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSG 180
            QTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSG
Sbjct: 121  QTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSG 180

Query: 181  SCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVL 240
            SCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVL
Sbjct: 181  SCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVL 240

Query: 241  QEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEF 300
            QEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEF
Sbjct: 241  QEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEF 300

Query: 301  DKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRS 360
            DKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRS
Sbjct: 301  DKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRS 360

Query: 361  TGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSYGRCSCKP 420
            TGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSYGRCSCKP
Sbjct: 361  TGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSYGRCSCKP 420

Query: 421  GVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPG 480
            GVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPG
Sbjct: 421  GVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPG 480

Query: 481  FFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAEQRDGSEASLEW 540
            FFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAEQRDGSEASLEW
Sbjct: 481  FFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAEQRDGSEASLEW 540

Query: 541  SSERQDIAVISDSYFPRYFIAPAKFLGKQVLSYGQNLSFSFRVDRRDTRLSAEDLVLEGA 600
            SSERQDIAVISDSYFPRYFIAPAKFLGKQVLSYGQNLSFSFRVDRRDTRLSAEDLVLEGA
Sbjct: 541  SSERQDIAVISDSYFPRYFIAPAKFLGKQVLSYGQNLSFSFRVDRRDTRLSAEDLVLEGA 600

Query: 601  GLRVSVPLIAQGNSYPSETTVKYVFRLHEATDYPWRPALTPFEFQKLLNNLTSIKIRGTY 660
            GLRVSVPLIAQGNSYPSETTVKYVFRLHEATDYPWRPALTPFEFQKLLNNLTSIKIRGTY
Sbjct: 601  GLRVSVPLIAQGNSYPSETTVKYVFRLHEATDYPWRPALTPFEFQKLLNNLTSIKIRGTY 660

Query: 661  SERSAGYLDDVTLASARPGPGVPATWVESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSP 720
            SERSAGYLDDVTLASARPGPGVPATWVESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSP
Sbjct: 661  SERSAGYLDDVTLASARPGPGVPATWVESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSP 720

Query: 721  CVLCACNGHSETCDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSS 780
            CVLCACNGHSETCDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSS
Sbjct: 721  CVLCACNGHSETCDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSS 780

Query: 781  CAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVG 840
            CAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVG
Sbjct: 781  CAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVG 840

Query: 841  NCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNP 900
            NCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNP
Sbjct: 841  NCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNP 900

Query: 901  VTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGI 960
            VTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGI
Sbjct: 901  VTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGI 960

Query: 961  TGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYF 1020
            TGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYF
Sbjct: 961  TGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYF 1020

Query: 1021 YNRSWPGCQECPACYRLVKDKVADHRVKLQELESLIANLGTGDEMVTDQAFEDRLKEAER 1080
            YNRSWPGCQECPACYRLVKDKVADHRVKLQELESLIANLGTGDEMVTDQAFEDRLKEAER
Sbjct: 1021 YNRSWPGCQECPACYRLVKDKVADHRVKLQELESLIANLGTGDEMVTDQAFEDRLKEAER 1080

Query: 1081 EVMDLLREAQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGNLAEQARAHVEN 1140
            EVMDLLREAQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGNLAEQARAHVEN
Sbjct: 1081 EVMDLLREAQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGNLAEQARAHVEN 1140

Query: 1141 TERLIEIASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRV 1200
            TERLIEIASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRV
Sbjct: 1141 TERLIEIASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRV 1200

Query: 1201 AKTANDTSTEAYNLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRA 1260
            AKTANDTSTEAYNLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRA
Sbjct: 1201 AKTANDTSTEAYNLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRA 1260

Query: 1261 GDKAVEIYASVAQLSPLDSETLENEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKELE 1320
            GDKAVEIYASVAQLSPLDSETLENEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKELE
Sbjct: 1261 GDKAVEIYASVAQLSPLDSETLENEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKELE 1320

Query: 1321 VKNLLEKGKTEQQTADQLLARADAAKALAEEAAKKGRDTLQEANDILNNLKDFDRRVNDN 1380
            VKNLLEKGKTEQQTADQLLARADAAKALAEEAAKKGRDTLQEANDILNNLKDFDRRVNDN
Sbjct: 1321 VKNLLEKGKTEQQTADQLLARADAAKALAEEAAKKGRDTLQEANDILNNLKDFDRRVNDN 1380

Query: 1381 KTAAEEALRKIPAINQTITEANEKTREAQQALGSAAADATEAKNKAHEAERIASAVQKNA 1440
            KTAAEEALRKIPAINQTITEANEKTREAQQALGSAAADATEAKNKAHEAERIASAVQKNA
Sbjct: 1381 KTAAEEALRKIPAINQTITEANEKTREAQQALGSAAADATEAKNKAHEAERIASAVQKNA 1440

Query: 1441 TSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDADQDMMMAGMASQAAQEAE 1500
            TSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDADQDMMMAGMASQAAQEAE
Sbjct: 1441 TSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDADQDMMMAGMASQAAQEAE 1500

Query: 1501 INARKAKNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDEMKVSDLDRKVSD 1560
            INARKAKNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDEMKVSDLDRKVSD
Sbjct: 1501 INARKAKNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDEMKVSDLDRKVSD 1560

Query: 1561 LENEAKKQEAAIMDYNRDIEEIMKDIRNLEDIRKTLPSGCFNTPSIEKP 1609
            LENEAKKQEAAIMDYNRDIEEIMKDIRNLEDIRKTLPSGCFNTPSIEKP
Sbjct: 1561 LENEAKKQEAAIMDYNRDIEEIMKDIRNLEDIRKTLPSGCFNTPSIEKP 1609


>gi|110611156 laminin, gamma 3 precursor [Homo sapiens]
          Length = 1575

 Score = 1384 bits (3583), Expect = 0.0
 Identities = 699/1595 (43%), Positives = 971/1595 (60%), Gaps = 48/1595 (3%)

Query: 21   LAVLAAAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFNVTVVATNTCGTPPEEYCVQT 80
            LA+LA  AA     A M  C D  GRPQRC+P F NAAF     A++TCG+PPE++C   
Sbjct: 10   LALLAPRAAG----AGMGACYDGAGRPQRCLPVFENAAFGRLAQASHTCGSPPEDFCPHV 65

Query: 81   GVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQYPSSINLTLHLG 140
            G  G    C  CDA  P   H A++LTD+++Q ++TWWQS +M  GVQYP+S+N+TL LG
Sbjct: 66   GAAGAGAHCQRCDAADPQRHHNASYLTDFHSQDESTWWQSPSMAFGVQYPTSVNITLRLG 125

Query: 141  KAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTGGDE 200
            KA++ITYVRLKFHTSRPESFAIYKR+R DGPW PYQ+YS SC+ TY +    ++R G DE
Sbjct: 126  KAYEITYVRLKFHTSRPESFAIYKRSRADGPWEPYQFYSASCQKTYGRPEGQYLRPGEDE 185

Query: 201  QQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFG 260
            + A CT EFSDISPL+GGNVAFSTLEGRPSAYNF+ SP LQEWVT+T++ ++L+RLNTFG
Sbjct: 186  RVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPGLQEWVTSTELLISLDRLNTFG 245

Query: 261  DEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCL 320
            D++F DPKVL+SYYYA+SDF+VGGRCKCNGHASEC  +   +L C C+HNT G DCE+CL
Sbjct: 246  DDIFKDPKVLQSYYYAVSDFSVGGRCKCNGHASECGPDVAGQLACRCQHNTTGTDCERCL 305

Query: 321  PFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCE 380
            PFF DRPW R TAE+A ECLPC+C+GRS+EC FD EL+RSTGHGG C +C+D+T G HCE
Sbjct: 306  PFFQDRPWARGTAEAAHECLPCNCSGRSEECTFDRELFRSTGHGGRCHHCRDHTAGPHCE 365

Query: 381  RCRENFFRLGNNEACSSCHCSPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEA 440
            RC+ENF+       C  C C   GSL  QCD  G C+CKP V G KCDRC PGFHSL+E 
Sbjct: 366  RCQENFYHWDPRMPCQPCDCQSAGSLHLQCDDTGTCACKPTVTGWKCDRCLPGFHSLSEG 425

Query: 441  GCRPCSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGH 500
            GCRPC+C+P+GS+D C+  +GRC CK+NVEG  C+RC+PG FNL+  NP GC+ CFC+GH
Sbjct: 426  GCRPCTCNPAGSLDTCDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFCYGH 485

Query: 501  SSVCTNAVGYSVYSISSTFQIDEDGWRAEQRDGSEASLEWSSERQDIAVISDSYFPRYFI 560
            S VC +   + V+ I S F    +GW A    GSE   +WS       V+          
Sbjct: 486  SKVCASTAQFQVHHILSDFHQGAEGWWARSVGGSEHPPQWSPN----GVLLSPEDEEELT 541

Query: 561  APAKFLGKQVLSYGQNLSFSFRVDRRDTRLSAEDLVLEGAGLRVSVPLIA----QGNSYP 616
            AP KFLG Q  SYGQ L  +FRV   D+ L  + L LEG GL +S+   +    Q   +P
Sbjct: 542  APEKFLGDQRFSYGQPLILTFRVPPGDSPLPVQ-LRLEGTGLALSLRHSSLSGPQDAGHP 600

Query: 617  SETTVKYVFRLHEATDYPWRPALTPFEFQKLLNNLTSIKIRGTYSERSAG--YLDDVTLA 674
             E  ++  F L E T     P L PF FQ+LL NLTS+++R +     AG  +L +V L 
Sbjct: 601  REVELR--FHLQE-TSEDVAPPLPPFHFQRLLANLTSLRLRVSPGPSPAGPVFLTEVRLT 657

Query: 675  SARPGPGVPATWVESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCD 734
            SARPG   PA+WVE C+CP GY GQFCE C  GY+RE P  GPY+ CV C CN H  TCD
Sbjct: 658  SARPGLSPPASWVEICSCPTGYTGQFCESCAPGYKREMPQGGPYASCVPCTCNQHG-TCD 716

Query: 735  PETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTN 794
            P TG+C C  +T GP CE+C  G+YG+  AG + DCQPCPCPG S+C  +P+++EVVCT+
Sbjct: 717  PNTGICVCSHHTEGPSCERCLPGFYGNPFAGQADDCQPCPCPGQSACTTIPESREVVCTH 776

Query: 795  CPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIY 854
            CP G  G+RCE+CDDG+FGDPLG  G  + C  CQCS N+DPNAVGNC+ L+G CL+C++
Sbjct: 777  CPPGQRGRRCEVCDDGFFGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLH 836

Query: 855  NTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQ 914
            NT G +C+ C++GF+G+ LAP PADKC  C+C+  G++ +Q  C+PVTGQC CLPHVT +
Sbjct: 837  NTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTAR 896

Query: 915  DCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFG 974
            DC  C PGF++LQ G+GC  C CH LGS   QC  +TGQC C+PG+TGQ C+RC++  FG
Sbjct: 897  DCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQACDRCQLGFFG 956

Query: 975  FGPEGCKPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPAC 1034
            F  +GC+ C C P G+ S QC ++G C CR GF G +CD+C +N+F       CQ+CP+C
Sbjct: 957  FSIKGCRACRCSPLGAASAQCHENGTCVCRPGFEGYKCDRCHDNFFLTADGTHCQQCPSC 1016

Query: 1035 YRLVKDKVADHRVKLQELESLIANLGTGDEMVTDQAFEDRLKEAEREVMDLLREAQDVKD 1094
            Y LVK++ A  + +L   E  +     G         +  L EA R   D+ +    +  
Sbjct: 1017 YALVKEEAAKLKARLTLTEGWLQGSDCGSPW---GPLDILLGEAPRG--DVYQGHHLLPG 1071

Query: 1095 VDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGNLAEQARAHVENTERLIEIASRELEK 1154
              +  ++++  +   + +   +LQ +          +++    + + E ++E +  E+  
Sbjct: 1072 AREAFLEQMMSLEGAVKAAREQLQRLNKGARCAQAGSQKTCTQLADLEAVLESSEEEILH 1131

Query: 1155 AKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNL 1214
            A    A++ + Q E    P   + LA EAR LA  H+  A  I   A  A   S  +Y L
Sbjct: 1132 AAAILASLEIPQ-EGPSQPTKWSHLATEARALARSHRDTATKIAATAWRALLASNTSYAL 1190

Query: 1215 LLRTLAGENQTAFEIE-ELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYAS--- 1270
            L   L  E + A E + +L  +Y++ +   + L    A V  EA+       ++ A    
Sbjct: 1191 LWNLL--EGRVALETQRDLEDRYQEVQAAQKALRTAVAEVLPEAESVLATVQQVGADTAP 1248

Query: 1271 -VAQLSPLDSETLENEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGK 1329
             +A L+   +   ++ A ++ ++A+ LE+ +      ++ +  +   + L+        +
Sbjct: 1249 YLALLASPGALPQKSRAEDLGLKAKALEKTV----ASWQHMATE-AARTLQTAAQATLRQ 1303

Query: 1330 TEQQTADQLLARADAAKALAEEAAKKGRDTLQEANDILNNLKDFDRRVNDNKTAAEEALR 1389
            TE  T  +L   A AA   A  + +    T+  A  +L +L+    +    K  A    +
Sbjct: 1304 TEPLT--KLHQEARAALTQASSSVQAATVTVMGARTLLADLEGMKLQFPRPKDQAALQRK 1361

Query: 1390 KIPAINQTITEANEKTREAQQALGSAAADATEAKNKAHEAERIASAVQKNATSTKAEAER 1449
                 ++ + +  +KT++A++ LG+AA  ++ AK K  EAE +A    K A +   E ++
Sbjct: 1362 ADSVSDRLLADTRKKTKQAERMLGNAAPLSSSAKKKGREAEVLAKDSAKLAKALLRERKQ 1421

Query: 1450 TFAEVTDLDNEVNNMLKQL-QEAEKELKRKQDDADQDMMMAGMASQAAQEAEINARKAKN 1508
                 + L ++    L+Q  Q+      R+Q+  + + + AG++     E E   R+++ 
Sbjct: 1422 AHRRASRLTSQTQATLQQASQQVLASEARRQELEEAERVGAGLS-----EMEQQIRESRI 1476

Query: 1509 SVTSLLSIINDLLEQLGQLDT--VDLNKLNEIEGTLNKAKDEM-KVSDLDRKVSDLENEA 1565
            S+   +  +++LL +LG LDT       LNE +  L + + ++     L RK+S LE E+
Sbjct: 1477 SLEKDIETLSELLARLGSLDTHQAPAQALNETQWALERLRLQLGSPGSLQRKLSLLEQES 1536

Query: 1566 KKQEAAIMDYNRDIEEIMKDIRNLEDIRKTLPSGC 1600
            ++QE  I  +  D+ EI  D +NLE I  +LP  C
Sbjct: 1537 QQQELQIQGFESDLAEIRADKQNLEAILHSLPENC 1571


>gi|157419140 laminin, gamma 2 isoform b precursor [Homo sapiens]
          Length = 1111

 Score =  709 bits (1829), Expect = 0.0
 Identities = 329/618 (53%), Positives = 411/618 (66%), Gaps = 23/618 (3%)

Query: 319 CLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAH 378
           CL F    P  RAT+        CDCNG+S++C FD EL+R TG+G  C NC DNTDG H
Sbjct: 9   CLCFSLLLPAARATSRREV----CDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIH 64

Query: 379 CERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLT 438
           CE+C+  F+R    + C  C+C+  GSLS +CD+ GRCSCKPGV G +CDRC PGFH LT
Sbjct: 65  CEKCKNGFYRHRERDRCLPCNCNSKGSLSARCDNSGRCSCKPGVTGARCDRCLPGFHMLT 124

Query: 439 EAGCRP--------CSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPR 490
           +AGC          C CDP+G    C  + GRCVCK  V G  C+RC+ G++NL+  NP 
Sbjct: 125 DAGCTQDQRLLDSKCDCDPAGIAGPC--DAGRCVCKPAVTGERCDRCRSGYYNLDGGNPE 182

Query: 491 GCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAEQRDGSEASLEWSSERQDIAVI 550
           GCT CFC+GHS+ C ++  YSV+ I+STF  D DGW+A QR+GS A L+WS   QD+   
Sbjct: 183 GCTQCFCYGHSASCRSSAEYSVHKITSTFHQDVDGWKAVQRNGSPAKLQWSQRHQDVFSS 242

Query: 551 SDSYFPRYFIAPAKFLGKQVLSYGQNLSFSFRVDRRDTRLSAEDLVLEGAGLRVSVPLIA 610
           +    P YF+APAKFLG Q +SYGQ+LSF +RVDR     SA D++LEGAGLR++ PL+ 
Sbjct: 243 AQRLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAHDVILEGAGLRITAPLMP 302

Query: 611 QGNSYPSETTVKYVFRLHEATDYPWRPALTPFEFQKLLNNLTSIKIRGTYSERSAGYLDD 670
            G + P   T  Y FRL+E     W P L+ FE+++LL NLT+++IR TY E S GY+D+
Sbjct: 303 LGKTLPCGLTKTYTFRLNEHPSNNWSPQLSYFEYRRLLRNLTALRIRATYGEYSTGYIDN 362

Query: 671 VTLASARPGPGVPATWVESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHS 730
           VTL SARP  G PA WVE C CPVGY GQFC+ C SGY+R++  LGP+  C+ C C G  
Sbjct: 363 VTLISARPVSGAPAPWVEQCICPVGYKGQFCQDCASGYKRDSARLGPFGTCIPCNCQG-G 421

Query: 731 ETCDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEV 790
             CDP+TG C   D      C  C  G+Y D     S  C+PCPC  G SC+V+P+T+EV
Sbjct: 422 GACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRS--CKPCPCHNGFSCSVMPETEEV 479

Query: 791 VCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECL 850
           VC NCP G TG RCELC DGYFGDP G +GPVR C+ CQC++N+DP+A GNC+RLTG CL
Sbjct: 480 VCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCL 539

Query: 851 KCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPH 910
           KCI+NTAG YCD+CK G+FG+PLAPNPADKC+ACNCN  G+  +   C    G C C P 
Sbjct: 540 KCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCNPMGS--EPVGCRS-DGTCVCKPG 596

Query: 911 VTGQDC--GACD-PGFYN 925
             G +C  GA   P  YN
Sbjct: 597 FGGPNCEHGAFSCPACYN 614



 Score =  372 bits (954), Expect = e-102
 Identities = 237/792 (29%), Positives = 403/792 (50%), Gaps = 58/792 (7%)

Query: 755  SDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGD 814
            S GY  + T  ++      P P    C             CP G  G+ C+ C  GY  D
Sbjct: 356  STGYIDNVTLISARPVSGAPAPWVEQCI------------CPVGYKGQFCQDCASGYKRD 403

Query: 815  PLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLA 874
               R GP   C  C C         G C+  TG+C     N     C  C  GF+ +P  
Sbjct: 404  S-ARLGPFGTCIPCNCQGG------GACDPDTGDCYSGDENP-DIECADCPIGFYNDPHD 455

Query: 875  PNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQG--- 931
            P     CK C C+   +         V     C P VTG  C  C  G++    G+    
Sbjct: 456  PR---SCKPCPCHNGFSCSVMPETEEVVCN-NCPPGVTGARCELCADGYFGDPFGEHGPV 511

Query: 932  --CERCDCH--ALGSTNGQCDIRTGQC-ECQPGITGQHCERCEVNHFG--FGP---EGCK 981
              C+ C C+     S +G CD  TG+C +C     G +C++C+  +FG    P   + C+
Sbjct: 512  RPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCR 571

Query: 982  PCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPACYRLVKDK 1041
             C+C+P GS  + C+ DG C C+ GF G  C+             G   CPACY  VK +
Sbjct: 572  ACNCNPMGSEPVGCRSDGTCVCKPGFGGPNCEH------------GAFSCPACYNQVKIQ 619

Query: 1042 VADHRVKLQELESLIANLGTGDEMVTDQAFEDRLKEAEREVMDLLREAQDVKDVDQNLMD 1101
            +     +LQ +E+LI+    GD +V D   E R+++AE+ + D+LR+AQ  +   ++L  
Sbjct: 620  MDQFMQQLQRMEALISKAQGGDGVVPDTELEGRMQQAEQALQDILRDAQISEGASRSLGL 679

Query: 1102 RLQRVNNTLSSQISRLQNIRNTIEETGNLAEQARAHVENTERLIEIASRELEKAKVAAAN 1161
            +L +V +  +S  SRL +++ T+E    L  Q +  V +T RLI      L +++ +  N
Sbjct: 680  QLAKVRSQENSYQSRLDDLKMTVERVRALGSQYQNRVRDTHRLITQMQLSLAESEASLGN 739

Query: 1162 VSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLLLRTL-- 1219
             ++   +    PN    LA+EA +LAE H + A ++ ++ +   D S +A +L+ + L  
Sbjct: 740  TNIPASDHYVGPNGFKSLAQEATRLAESHVESASNMEQLTRETEDYSKQALSLVRKALHE 799

Query: 1220 -----AGENQTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQL 1274
                 +G    A  ++ L  K E+ K+++Q L ++A +   EA R+   ++ +  SV++L
Sbjct: 800  GVGSGSGSPDGAV-VQGLVEKLEKTKSLAQQLTREATQAEIEADRSYQHSLRLLDSVSRL 858

Query: 1275 SPLDSETLE-NEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQQ 1333
              +  ++ +  EA  IK +A++L  L+ + + +++  ++++   + E + LL+ GK+ ++
Sbjct: 859  QGVSDQSFQVEEAKRIKQKADSLSSLVTRHMDEFKRTQKNLGNWKEEAQQLLQNGKSGRE 918

Query: 1334 TADQLLARADAAKALAEEAAKKGRDTLQEANDILNNLKDFDRRVNDNKTAAEEALRKIPA 1393
             +DQLL+RA+ AK+ A+EA   G  T  E   IL NL++FD +V++ K  AEEA++++  
Sbjct: 919  KSDQLLSRANLAKSRAQEALSMGNATFYEVESILKNLREFDLQVDNRKAEAEEAMKRLSY 978

Query: 1394 INQTITEANEKTREAQQALGSAAADATEAKNKAHEAERIASAVQKNATSTKAEAERTFAE 1453
            I+Q +++A++KT++A++ALGSAAADA  AKN A EA  I+S +++   S   EA  T   
Sbjct: 979  ISQKVSDASDKTQQAERALGSAAADAQRAKNGAGEALEISSEIEQEIGSLNLEANVTADG 1038

Query: 1454 VTDLDNEVNNMLKQLQEAEKELKRKQDDADQDMMMAGMASQAAQEAEINARKAKNSVTSL 1513
               ++  + ++  +++E E EL+RK+ + D +M    M    AQ+ +  A+ A  ++   
Sbjct: 1039 ALAMEKGLASLKSEMREVEGELERKELEFDTNMDAVQMVITEAQKVDTRAKNAGVTIQDT 1098

Query: 1514 LSIINDLLEQLG 1525
            L+ ++ LL  +G
Sbjct: 1099 LNTLDGLLHLMG 1110



 Score =  111 bits (278), Expect = 5e-24
 Identities = 60/158 (37%), Positives = 84/158 (53%), Gaps = 25/158 (15%)

Query: 843 NRLTGE---CLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCN 899
           +R TG    CL C  NT G +C++CK+GF+ +       D+C  CNCN  G++  +  C+
Sbjct: 44  HRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRH----RERDRCLPCNCNSKGSLSAR--CD 97

Query: 900 PVTGQCECLPHVTGQDCGACDPGFYNLQSGQGC--------ERCDCHALGSTNGQCDIRT 951
             +G+C C P VTG  C  C PGF+ L    GC         +CDC   G   G CD   
Sbjct: 98  N-SGRCSCKPGVTGARCDRCLPGFHMLTDA-GCTQDQRLLDSKCDCDPAGIA-GPCD--A 152

Query: 952 GQCECQPGITGQHCERCEVNHF---GFGPEGCKPCDCH 986
           G+C C+P +TG+ C+RC   ++   G  PEGC  C C+
Sbjct: 153 GRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCY 190



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 55/177 (31%), Positives = 78/177 (44%), Gaps = 21/177 (11%)

Query: 874  APNPADKCKACNCNLYGTMKQ---QSSCNPVTGQ----CECLPHVTGQDCGACDPGFYNL 926
            A     + + C+CN  G  +Q       +  TG       C  +  G  C  C  GFY  
Sbjct: 18   AARATSRREVCDCN--GKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRH 75

Query: 927  QSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGC------ 980
            +    C  C+C++ GS + +CD  +G+C C+PG+TG  C+RC          GC      
Sbjct: 76   RERDRCLPCNCNSKGSLSARCD-NSGRCSCKPGVTGARCDRCLPGFHMLTDAGCTQDQRL 134

Query: 981  --KPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPACY 1035
                CDC P G ++  C D GRC C+    G RCD+C   Y YN      + C  C+
Sbjct: 135  LDSKCDCDPAG-IAGPC-DAGRCVCKPAVTGERCDRCRSGY-YNLDGGNPEGCTQCF 188



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 48/149 (32%), Positives = 66/149 (44%), Gaps = 13/149 (8%)

Query: 286 CKCNGHASECMKNEFDKLVCN-CKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDC 344
           C C+   S  +  E +++VCN C     G  CE C   +   P+          C PC C
Sbjct: 462 CPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPF--GEHGPVRPCQPCQC 519

Query: 345 NGRSQECYFDPELYRSTGH-GGHCTNCQDNTDGAHCERCRENFF--RLGNNEA--CSSCH 399
           N        DP    +     G C  C  NT G +C++C+  +F   L  N A  C +C+
Sbjct: 520 NNN-----VDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACN 574

Query: 400 CSPVGSLSTQCDSYGRCSCKPGVMGDKCD 428
           C+P+GS    C S G C CKPG  G  C+
Sbjct: 575 CNPMGSEPVGCRSDGTCVCKPGFGGPNCE 603



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 49/152 (32%), Positives = 67/152 (44%), Gaps = 19/152 (12%)

Query: 792 CTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLK 851
           C NC   T G  CE C +G++     R+     C  C C+     +A   C+  +G C  
Sbjct: 53  CLNCNDNTDGIHCEKCKNGFY-----RHRERDRCLPCNCNSKGSLSA--RCDN-SGRC-S 103

Query: 852 CIYNTAGFYCDRCKDGFFGNPLAPNPADKC---KACNCNLYGTMKQQSSCNPVTGQCECL 908
           C     G  CDRC  GF     A    D+      C+C+  G       C+   G+C C 
Sbjct: 104 CKPGVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCDCDPAGIA---GPCD--AGRCVCK 158

Query: 909 PHVTGQDCGACDPGFYNLQSG--QGCERCDCH 938
           P VTG+ C  C  G+YNL  G  +GC +C C+
Sbjct: 159 PAVTGERCDRCRSGYYNLDGGNPEGCTQCFCY 190



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 82/432 (18%), Positives = 175/432 (40%), Gaps = 44/432 (10%)

Query: 1188 ERHKQEADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLE 1247
            ++ +Q   DI+R A+ +   S      L +  + EN     +++L    E+ + +    +
Sbjct: 654  QQAEQALQDILRDAQISEGASRSLGLQLAKVRSQENSYQSRLDDLKMTVERVRALGSQYQ 713

Query: 1248 KQAARVHEEAKRAGDKAVEIYASVAQ---------LSPLDSETLENEANNIKME----AE 1294
             +    H    +      E  AS+           + P   ++L  EA  +       A 
Sbjct: 714  NRVRDTHRLITQMQLSLAESEASLGNTNIPASDHYVGPNGFKSLAQEATRLAESHVESAS 773

Query: 1295 NLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQQTADQLLARADAAKALAEEAAK 1354
            N+EQL  ++ +DY      +  K L        G  +      L+ + +  K+LA++  +
Sbjct: 774  NMEQLT-RETEDYSKQALSLVRKALHEGVGSGSGSPDGAVVQGLVEKLEKTKSLAQQLTR 832

Query: 1355 KGRDTLQEAN-DILNNLKDFD-----RRVNDNKTAAEEALR---KIPAINQTITEANEKT 1405
            +      EA+    ++L+  D     + V+D     EEA R   K  +++  +T   ++ 
Sbjct: 833  EATQAEIEADRSYQHSLRLLDSVSRLQGVSDQSFQVEEAKRIKQKADSLSSLVTRHMDEF 892

Query: 1406 REAQQALGSAAADATEAKNKAHEAERIASAVQKNATSTKAEAERTFAEVTDLDNEVNNML 1465
            +  Q+ LG+   +A +           +  +   A   K+ A+   +       EV ++L
Sbjct: 893  KRTQKNLGNWKEEAQQLLQNGKSGREKSDQLLSRANLAKSRAQEALSMGNATFYEVESIL 952

Query: 1466 KQLQEAEKELKRKQDDADQDMMMAGMASQAAQEAE--------------INARKAKNSVT 1511
            K L+E + ++  ++ +A++ M      SQ   +A                +A++AKN   
Sbjct: 953  KNLREFDLQVDNRKAEAEEAMKRLSYISQKVSDASDKTQQAERALGSAAADAQRAKNGAG 1012

Query: 1512 SLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDEMKVSDLDRKVSDLENEAKKQEAA 1571
              L I +++ +++G L   +L      +G L   K    ++ L  ++ ++E E +++E  
Sbjct: 1013 EALEISSEIEQEIGSL---NLEANVTADGALAMEKG---LASLKSEMREVEGELERKELE 1066

Query: 1572 IMDYNRDIEEIM 1583
              D N D  +++
Sbjct: 1067 -FDTNMDAVQMV 1077



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 13/117 (11%)

Query: 286 CKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCN 345
           C CN   S   + + +   C+CK    G  C++CLP F+       T +       CDC 
Sbjct: 84  CNCNSKGSLSARCD-NSGRCSCKPGVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCDC- 141

Query: 346 GRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRL--GNNEACSSCHC 400
                   DP         G C  C+    G  C+RCR  ++ L  GN E C+ C C
Sbjct: 142 --------DPAGIAGPCDAGRCV-CKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFC 189


>gi|157419138 laminin, gamma 2 isoform a precursor [Homo sapiens]
          Length = 1193

 Score =  709 bits (1829), Expect = 0.0
 Identities = 329/618 (53%), Positives = 411/618 (66%), Gaps = 23/618 (3%)

Query: 319 CLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAH 378
           CL F    P  RAT+        CDCNG+S++C FD EL+R TG+G  C NC DNTDG H
Sbjct: 9   CLCFSLLLPAARATSRREV----CDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIH 64

Query: 379 CERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLT 438
           CE+C+  F+R    + C  C+C+  GSLS +CD+ GRCSCKPGV G +CDRC PGFH LT
Sbjct: 65  CEKCKNGFYRHRERDRCLPCNCNSKGSLSARCDNSGRCSCKPGVTGARCDRCLPGFHMLT 124

Query: 439 EAGCRP--------CSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPR 490
           +AGC          C CDP+G    C  + GRCVCK  V G  C+RC+ G++NL+  NP 
Sbjct: 125 DAGCTQDQRLLDSKCDCDPAGIAGPC--DAGRCVCKPAVTGERCDRCRSGYYNLDGGNPE 182

Query: 491 GCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAEQRDGSEASLEWSSERQDIAVI 550
           GCT CFC+GHS+ C ++  YSV+ I+STF  D DGW+A QR+GS A L+WS   QD+   
Sbjct: 183 GCTQCFCYGHSASCRSSAEYSVHKITSTFHQDVDGWKAVQRNGSPAKLQWSQRHQDVFSS 242

Query: 551 SDSYFPRYFIAPAKFLGKQVLSYGQNLSFSFRVDRRDTRLSAEDLVLEGAGLRVSVPLIA 610
           +    P YF+APAKFLG Q +SYGQ+LSF +RVDR     SA D++LEGAGLR++ PL+ 
Sbjct: 243 AQRLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAHDVILEGAGLRITAPLMP 302

Query: 611 QGNSYPSETTVKYVFRLHEATDYPWRPALTPFEFQKLLNNLTSIKIRGTYSERSAGYLDD 670
            G + P   T  Y FRL+E     W P L+ FE+++LL NLT+++IR TY E S GY+D+
Sbjct: 303 LGKTLPCGLTKTYTFRLNEHPSNNWSPQLSYFEYRRLLRNLTALRIRATYGEYSTGYIDN 362

Query: 671 VTLASARPGPGVPATWVESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHS 730
           VTL SARP  G PA WVE C CPVGY GQFC+ C SGY+R++  LGP+  C+ C C G  
Sbjct: 363 VTLISARPVSGAPAPWVEQCICPVGYKGQFCQDCASGYKRDSARLGPFGTCIPCNCQG-G 421

Query: 731 ETCDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEV 790
             CDP+TG C   D      C  C  G+Y D     S  C+PCPC  G SC+V+P+T+EV
Sbjct: 422 GACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRS--CKPCPCHNGFSCSVMPETEEV 479

Query: 791 VCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECL 850
           VC NCP G TG RCELC DGYFGDP G +GPVR C+ CQC++N+DP+A GNC+RLTG CL
Sbjct: 480 VCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCL 539

Query: 851 KCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPH 910
           KCI+NTAG YCD+CK G+FG+PLAPNPADKC+ACNCN  G+  +   C    G C C P 
Sbjct: 540 KCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCNPMGS--EPVGCRS-DGTCVCKPG 596

Query: 911 VTGQDC--GACD-PGFYN 925
             G +C  GA   P  YN
Sbjct: 597 FGGPNCEHGAFSCPACYN 614



 Score =  417 bits (1073), Expect = e-116
 Identities = 266/875 (30%), Positives = 452/875 (51%), Gaps = 59/875 (6%)

Query: 755  SDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGD 814
            S GY  + T  ++      P P    C             CP G  G+ C+ C  GY  D
Sbjct: 356  STGYIDNVTLISARPVSGAPAPWVEQCI------------CPVGYKGQFCQDCASGYKRD 403

Query: 815  PLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLA 874
               R GP   C  C C         G C+  TG+C     N     C  C  GF+ +P  
Sbjct: 404  S-ARLGPFGTCIPCNCQGG------GACDPDTGDCYSGDENP-DIECADCPIGFYNDPHD 455

Query: 875  PNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQG--- 931
            P     CK C C+   +         V     C P VTG  C  C  G++    G+    
Sbjct: 456  PR---SCKPCPCHNGFSCSVMPETEEVVCN-NCPPGVTGARCELCADGYFGDPFGEHGPV 511

Query: 932  --CERCDCH--ALGSTNGQCDIRTGQC-ECQPGITGQHCERCEVNHFG--FGP---EGCK 981
              C+ C C+     S +G CD  TG+C +C     G +C++C+  +FG    P   + C+
Sbjct: 512  RPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCR 571

Query: 982  PCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPACYRLVKDK 1041
             C+C+P GS  + C+ DG C C+ GF G  C+             G   CPACY  VK +
Sbjct: 572  ACNCNPMGSEPVGCRSDGTCVCKPGFGGPNCEH------------GAFSCPACYNQVKIQ 619

Query: 1042 VADHRVKLQELESLIANLGTGDEMVTDQAFEDRLKEAEREVMDLLREAQDVKDVDQNLMD 1101
            +     +LQ +E+LI+    GD +V D   E R+++AE+ + D+LR+AQ  +   ++L  
Sbjct: 620  MDQFMQQLQRMEALISKAQGGDGVVPDTELEGRMQQAEQALQDILRDAQISEGASRSLGL 679

Query: 1102 RLQRVNNTLSSQISRLQNIRNTIEETGNLAEQARAHVENTERLIEIASRELEKAKVAAAN 1161
            +L +V +  +S  SRL +++ T+E    L  Q +  V +T RLI      L +++ +  N
Sbjct: 680  QLAKVRSQENSYQSRLDDLKMTVERVRALGSQYQNRVRDTHRLITQMQLSLAESEASLGN 739

Query: 1162 VSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLLLRTL-- 1219
             ++   +    PN    LA+EA +LAE H + A ++ ++ +   D S +A +L+ + L  
Sbjct: 740  TNIPASDHYVGPNGFKSLAQEATRLAESHVESASNMEQLTRETEDYSKQALSLVRKALHE 799

Query: 1220 -----AGENQTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQL 1274
                 +G    A  ++ L  K E+ K+++Q L ++A +   EA R+   ++ +  SV++L
Sbjct: 800  GVGSGSGSPDGAV-VQGLVEKLEKTKSLAQQLTREATQAEIEADRSYQHSLRLLDSVSRL 858

Query: 1275 SPLDSETLE-NEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQQ 1333
              +  ++ +  EA  IK +A++L  L+ + + +++  ++++   + E + LL+ GK+ ++
Sbjct: 859  QGVSDQSFQVEEAKRIKQKADSLSSLVTRHMDEFKRTQKNLGNWKEEAQQLLQNGKSGRE 918

Query: 1334 TADQLLARADAAKALAEEAAKKGRDTLQEANDILNNLKDFDRRVNDNKTAAEEALRKIPA 1393
             +DQLL+RA+ AK+ A+EA   G  T  E   IL NL++FD +V++ K  AEEA++++  
Sbjct: 919  KSDQLLSRANLAKSRAQEALSMGNATFYEVESILKNLREFDLQVDNRKAEAEEAMKRLSY 978

Query: 1394 INQTITEANEKTREAQQALGSAAADATEAKNKAHEAERIASAVQKNATSTKAEAERTFAE 1453
            I+Q +++A++KT++A++ALGSAAADA  AKN A EA  I+S +++   S   EA  T   
Sbjct: 979  ISQKVSDASDKTQQAERALGSAAADAQRAKNGAGEALEISSEIEQEIGSLNLEANVTADG 1038

Query: 1454 VTDLDNEVNNMLKQLQEAEKELKRKQDDADQDMMMAGMASQAAQEAEINARKAKNSVTSL 1513
               ++  + ++  +++E E EL+RK+ + D +M    M    AQ+ +  A+ A  ++   
Sbjct: 1039 ALAMEKGLASLKSEMREVEGELERKELEFDTNMDAVQMVITEAQKVDTRAKNAGVTIQDT 1098

Query: 1514 LSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDEMKVSDLDRKVSDLENEAKKQEAAIM 1573
            L+ ++ LL  + Q  +VD   L  +E  L++AK ++  S L   +S+LE  A++Q   + 
Sbjct: 1099 LNTLDGLLHLMDQPLSVDEEGLVLLEQKLSRAKTQIN-SQLRPMMSELEERARQQRGHLH 1157

Query: 1574 DYNRDIEEIMKDIRNLEDIRKTLPSGCFNTPSIEK 1608
                 I+ I+ D++NLE+IR  LP GC+NT ++E+
Sbjct: 1158 LLETSIDGILADVKNLENIRDNLPPGCYNTQALEQ 1192



 Score =  111 bits (278), Expect = 5e-24
 Identities = 60/158 (37%), Positives = 84/158 (53%), Gaps = 25/158 (15%)

Query: 843 NRLTGE---CLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCN 899
           +R TG    CL C  NT G +C++CK+GF+ +       D+C  CNCN  G++  +  C+
Sbjct: 44  HRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRH----RERDRCLPCNCNSKGSLSAR--CD 97

Query: 900 PVTGQCECLPHVTGQDCGACDPGFYNLQSGQGC--------ERCDCHALGSTNGQCDIRT 951
             +G+C C P VTG  C  C PGF+ L    GC         +CDC   G   G CD   
Sbjct: 98  N-SGRCSCKPGVTGARCDRCLPGFHMLTDA-GCTQDQRLLDSKCDCDPAGIA-GPCD--A 152

Query: 952 GQCECQPGITGQHCERCEVNHF---GFGPEGCKPCDCH 986
           G+C C+P +TG+ C+RC   ++   G  PEGC  C C+
Sbjct: 153 GRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCY 190



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 55/177 (31%), Positives = 78/177 (44%), Gaps = 21/177 (11%)

Query: 874  APNPADKCKACNCNLYGTMKQ---QSSCNPVTGQ----CECLPHVTGQDCGACDPGFYNL 926
            A     + + C+CN  G  +Q       +  TG       C  +  G  C  C  GFY  
Sbjct: 18   AARATSRREVCDCN--GKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRH 75

Query: 927  QSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGC------ 980
            +    C  C+C++ GS + +CD  +G+C C+PG+TG  C+RC          GC      
Sbjct: 76   RERDRCLPCNCNSKGSLSARCD-NSGRCSCKPGVTGARCDRCLPGFHMLTDAGCTQDQRL 134

Query: 981  --KPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPACY 1035
                CDC P G ++  C D GRC C+    G RCD+C   Y YN      + C  C+
Sbjct: 135  LDSKCDCDPAG-IAGPC-DAGRCVCKPAVTGERCDRCRSGY-YNLDGGNPEGCTQCF 188



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 48/149 (32%), Positives = 66/149 (44%), Gaps = 13/149 (8%)

Query: 286 CKCNGHASECMKNEFDKLVCN-CKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDC 344
           C C+   S  +  E +++VCN C     G  CE C   +   P+          C PC C
Sbjct: 462 CPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPF--GEHGPVRPCQPCQC 519

Query: 345 NGRSQECYFDPELYRSTGH-GGHCTNCQDNTDGAHCERCRENFF--RLGNNEA--CSSCH 399
           N        DP    +     G C  C  NT G +C++C+  +F   L  N A  C +C+
Sbjct: 520 NNN-----VDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACN 574

Query: 400 CSPVGSLSTQCDSYGRCSCKPGVMGDKCD 428
           C+P+GS    C S G C CKPG  G  C+
Sbjct: 575 CNPMGSEPVGCRSDGTCVCKPGFGGPNCE 603



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 49/152 (32%), Positives = 67/152 (44%), Gaps = 19/152 (12%)

Query: 792 CTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLK 851
           C NC   T G  CE C +G++     R+     C  C C+     +A   C+  +G C  
Sbjct: 53  CLNCNDNTDGIHCEKCKNGFY-----RHRERDRCLPCNCNSKGSLSA--RCDN-SGRC-S 103

Query: 852 CIYNTAGFYCDRCKDGFFGNPLAPNPADKC---KACNCNLYGTMKQQSSCNPVTGQCECL 908
           C     G  CDRC  GF     A    D+      C+C+  G       C+   G+C C 
Sbjct: 104 CKPGVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCDCDPAGIA---GPCD--AGRCVCK 158

Query: 909 PHVTGQDCGACDPGFYNLQSG--QGCERCDCH 938
           P VTG+ C  C  G+YNL  G  +GC +C C+
Sbjct: 159 PAVTGERCDRCRSGYYNLDGGNPEGCTQCFCY 190



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 13/117 (11%)

Query: 286 CKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCN 345
           C CN   S   + + +   C+CK    G  C++CLP F+       T +       CDC 
Sbjct: 84  CNCNSKGSLSARCD-NSGRCSCKPGVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCDC- 141

Query: 346 GRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRL--GNNEACSSCHC 400
                   DP         G C  C+    G  C+RCR  ++ L  GN E C+ C C
Sbjct: 142 --------DPAGIAGPCDAGRCV-CKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFC 189


>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
          Length = 3075

 Score =  623 bits (1607), Expect = e-178
 Identities = 380/1087 (34%), Positives = 542/1087 (49%), Gaps = 122/1087 (11%)

Query: 20   VLAVLAAAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFNVTVVATNTCGTP-PEEYCV 78
            VL VL    AA C Q  +              P  +N A N  +    TCG   PE +C 
Sbjct: 5    VLLVLLLCVAAQCRQRGL-------------FPAILNLASNAHISTNATCGEKGPEMFCK 51

Query: 79   QT----GVTGVTKSCHLCD--AGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQYPSS 132
                  G       C +CD  +  P  +H  +   D  N     WWQS ++  G +Y   
Sbjct: 52   LVEHVPGRPVRNPQCRICDGNSANPRERHPISHAIDGTNN----WWQSPSIQNGREY-HW 106

Query: 133  INLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGS---CENTYSKA 189
            + +TL L + F + YV +K   +      I +R+ +   + P+QYY+ S   C + Y+  
Sbjct: 107  VTITLDLRQVFQVAYVIIKAANAPRPGNWILERSLDGTTFSPWQYYAVSDSECLSRYNIT 166

Query: 190  NRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDI 249
             R    T   + + +CT  +S + PL  G +  S + GRPSA   D SP L E+ +A  I
Sbjct: 167  PRRGPPTYRADDEVICTSYYSRLVPLEHGEIHTSLINGRPSAD--DLSPKLLEFTSARYI 224

Query: 250  RVTLNRLNTFGDEVFN---------DPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEF 300
            R+ L R+ T   ++           DP V + YYY+I D +VGG C C GHAS C  +E 
Sbjct: 225  RLRLQRIRTLNADLMTLSHREPKELDPIVTRRYYYSIKDISVGGMCICYGHASSCPWDET 284

Query: 301  DK-LVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYR 359
             K L C C+HNT G  C +C P ++ +PWR  T  S + C  C+C+ ++++CY+D  + +
Sbjct: 285  TKKLQCQCEHNTCGESCNRCCPGYHQQPWRPGTVSSGNTCEACNCHNKAKDCYYDESVAK 344

Query: 360  STGH---------GGHCTNCQDNTDGAHCERCRENFFRLGN-----NEACSSCHCSPVGS 405
                         GG C NC  NT G +CE C + ++R        +E C  C+C PVGS
Sbjct: 345  QKKSLNTAGQFRGGGVCINCLQNTMGINCETCIDGYYRPHKVSPYEDEPCRPCNCDPVGS 404

Query: 406  LSTQC------------DSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSI 453
            LS+ C               G+C CK G  G+KCDRCQ G+       C  C C+P GS 
Sbjct: 405  LSSVCIKDDLHSDLHNGKQPGQCPCKEGYTGEKCDRCQLGYKDYPT--CVSCGCNPVGSA 462

Query: 454  DE--CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYS 511
             +  C   TG CVCK+NVEG  C+RCKPGF+NL+  NPRGC+ CFCFG S VC +++ + 
Sbjct: 463  SDEPC---TGPCVCKENVEGKACDRCKPGFYNLKEKNPRGCSECFCFGVSDVC-SSLSWP 518

Query: 512  VYSISSTFQIDEDGWRAEQRDGSE---ASLEWSSERQDIAVISDSYFPR-----YFIAPA 563
            V  ++S       GW            +  +    R  +++ + +   R     Y+ AP 
Sbjct: 519  VGQVNSM-----SGWLVTDLISPRKIPSQQDALGGRHQVSINNTAVMQRLAPKYYWAAPE 573

Query: 564  KFLGKQVLSYG----QNLSFSFRVDRRDTRL-SAEDLVLEGAGLRVSVPLIAQGNSYPSE 618
             +LG ++ ++G      +S+   V+  D+ L S  D++++G GL +S    A+G S    
Sbjct: 574  AYLGNKLTAFGGFLKYTVSYDIPVETVDSNLMSHADVIIKGNGLTLSTQ--AEGLSLQPY 631

Query: 619  TTVKYVFRL--HEATDYPWRPALTPFEFQKLLNNLTSIKIRGTY-SERSAGY-LDDVTL- 673
                 V RL      D+  +  +   +   +L N+T + IR  Y S + A Y L+ V+L 
Sbjct: 632  EEYLNVVRLVPENFQDFHSKRQIDRDQLMTVLANVTHLLIRANYNSAKMALYRLESVSLD 691

Query: 674  -ASARPGPGVPATWVESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSET 732
             AS+     V A  VE C CP GY G  CE CLSGY R    L     C  C C+GH+  
Sbjct: 692  IASSNAIDLVVAADVEHCECPQGYTGTSCESCLSGYYRVDGILFG-GICQPCECHGHAAE 750

Query: 733  CDPETGVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCP------GGSSCAVVP 785
            C+   GVC  C  NT G HCE+C  G+YG+ + GT  DCQPC CP        S    + 
Sbjct: 751  CNVH-GVCIACAHNTTGVHCEQCLPGFYGEPSRGTPGDCQPCACPLTIASNNFSPTCHLN 809

Query: 786  KTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRL 845
               EVVC  C  G +G  CE C DGY+G+P     P   C  C CS N+DP+  G+C+ +
Sbjct: 810  DGDEVVCDWCAPGYSGAWCERCADGYYGNP---TVPGESCVPCDCSGNVDPSEAGHCDSV 866

Query: 846  TGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQC 905
            TGECLKC+ NT G +C+RC DGF+G+ +    A  C+AC C++ G+    + C+  TG C
Sbjct: 867  TGECLKCLGNTDGAHCERCADGFYGDAVT---AKNCRACECHVKGS--HSAVCHLETGLC 921

Query: 906  ECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHC 965
            +C P+VTGQ C  C  G+Y L SG GC  C+C   GS +  C    GQC C PG+ G+ C
Sbjct: 922  DCKPNVTGQQCDQCLHGYYGLDSGHGCRPCNCSVAGSVSDGC-TDEGQCHCVPGVAGKRC 980

Query: 966  ERCEVNHFGFGPEGCKPCDC-HPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRS 1024
            +RC    + +    C PCDC H + +      + G C C     G +C++CE+ ++   +
Sbjct: 981  DRCAHGFYAYQDGSCTPCDCPHTQNTCD---PETGECVCPPHTQGVKCEECEDGHWGYDA 1037

Query: 1025 WPGCQEC 1031
              GCQ C
Sbjct: 1038 EVGCQAC 1044



 Score =  287 bits (734), Expect = 7e-77
 Identities = 201/672 (29%), Positives = 291/672 (43%), Gaps = 122/672 (18%)

Query: 286  CKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFND-------RPWRRATAESASE 338
            C+C+   S       +  +C+CK N  G  C++CL  +         RP   + A S S+
Sbjct: 902  CECHVKGSHSAVCHLETGLCDCKPNVTGQQCDQCLHGYYGLDSGHGCRPCNCSVAGSVSD 961

Query: 339  ---------------------------------CLPCDCNGRSQECYFDPELYRSTGHGG 365
                                             C PCDC      C  DPE        G
Sbjct: 962  GCTDEGQCHCVPGVAGKRCDRCAHGFYAYQDGSCTPCDCPHTQNTC--DPET-------G 1012

Query: 366  HCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSY-GRCSCKPGVMG 424
             C  C  +T G  CE C +  +       C +C+CS VGS   +CD   G C CK    G
Sbjct: 1013 ECV-CPPHTQGVKCEECEDGHWGYDAEVGCQACNCSLVGSTHHRCDVVTGHCQCKSKFGG 1071

Query: 425  DKCDRCQPGFHSLTEAGCRPCSCDPSG-SIDECNIE---------TGRCVCKDNVEGFNC 474
              CD+C  G+    +  C PC CD  G S D CN+E         TG C CK+NV G  C
Sbjct: 1072 RACDQCSLGYRDFPD--CVPCDCDLRGTSGDACNLEQGLCGCVEETGACPCKENVFGPQC 1129

Query: 475  ERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAEQRDGS 534
              C+ G F L + NP GC+PCFC G S +C+    Y    +  T   D+   R   +   
Sbjct: 1130 NECREGTFALRADNPLGCSPCFCSGLSHLCSELEDYVRTPV--TLGSDQPLLRVVSQSNL 1187

Query: 535  EAS------------LEWSSERQDIAVISDSYFPRYFIAPAKFLGKQVLSYGQNLSFS-- 580
              +            L+ ++ RQ I        P Y+  P +F G Q+++YG  L +S  
Sbjct: 1188 RGTTEGVYYQAPDFLLDAATVRQHIRA-----EPFYWRLPQQFQGDQLMAYGGKLKYSVA 1242

Query: 581  -FRVDRRDTRLSAEDLVLEGAGLRVSV-----PLIAQGNSYPSETTVKYVF--RLHEATD 632
             + +D   T      ++++G  +R  V     P    G     E  ++  F    +  ++
Sbjct: 1243 FYSLDGVGTSNFEPQVLIKGGRIRKQVIYMDAPAPENGVRQEQEVAMRENFWKYFNSVSE 1302

Query: 633  YPWRPALTPFEFQKLLNNLTSIKIRGTYSE-RSAGYLDDVTLASARPGPGV-----PATW 686
             P    +T  +F  +L+++  I I+ +Y +      + D+++   R    +      A+ 
Sbjct: 1303 KP----VTREDFMSVLSDIEYILIKASYGQGLQQSRISDISMEVGRKAEKLHPEEEVASL 1358

Query: 687  VESCTCPVGYGGQFCEMCLSGYRR----ETPNLGP---YSPCVLCACNGHSETCDPETGV 739
            +E+C CP G  G  C+ C  GY R       + GP    +PCV C+CN HS+TCDP TG 
Sbjct: 1359 LENCVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTCDPNTGK 1418

Query: 740  C-NCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGG-----SSCAVVPKTKEVVCT 793
            C NC DNTAG HC+ C+ GYYG  T G++SDC  C CP       S   V+    +  C 
Sbjct: 1419 CLNCGDNTAGDHCDVCTSGYYGKVT-GSASDCALCACPHSPPASFSPTCVLEGDHDFRCD 1477

Query: 794  NCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCI 853
             C  G  GK CE C   Y+G+P    G    C+ C C  N   +  G+C+R +G+C+ C 
Sbjct: 1478 ACLLGYEGKHCERCSSSYYGNPQTPGGS---CQKCDC--NPHGSVHGDCDRTSGQCV-CR 1531

Query: 854  YNTAGFYCDRCK 865
               +G  CD C+
Sbjct: 1532 LGASGLRCDECE 1543



 Score =  216 bits (551), Expect = 1e-55
 Identities = 120/358 (33%), Positives = 174/358 (48%), Gaps = 44/358 (12%)

Query: 692  CPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSET-----CDPETGVC-NCRDN 745
            C  GY G +CE C  GY    P + P   CV C C+G+ +      CD  TG C  C  N
Sbjct: 819  CAPGYSGAWCERCADGYYGN-PTV-PGESCVPCDCSGNVDPSEAGHCDSVTGECLKCLGN 876

Query: 746  TAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCE 805
            T G HCE+C+DG+YGD+   T+ +C+ C C    S + V   +  +C +C    TG++C+
Sbjct: 877  TDGAHCERCADGFYGDAV--TAKNCRACECHVKGSHSAVCHLETGLC-DCKPNVTGQQCD 933

Query: 806  LCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCK 865
             C  GY+G   G       CR C CS  +  +    C    G+C  C+   AG  CDRC 
Sbjct: 934  QCLHGYYGLDSGHG-----CRPCNCS--VAGSVSDGCTD-EGQC-HCVPGVAGKRCDRCA 984

Query: 866  DGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYN 925
             GF+           C  C+C        Q++C+P TG+C C PH  G  C  C+ G + 
Sbjct: 985  HGFYAYQ-----DGSCTPCDCP-----HTQNTCDPETGECVCPPHTQGVKCEECEDGHWG 1034

Query: 926  LQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDC 985
              +  GC+ C+C  +GST+ +CD+ TG C+C+    G+ C++C + +  F    C PCDC
Sbjct: 1035 YDAEVGCQACNCSLVGSTHHRCDVVTGHCQCKSKFGGRACDQCSLGYRDF--PDCVPCDC 1092

Query: 986  HPEGSLSLQC----------KDDGRCECREGFVGNRCDQCEENYFYNRSWP--GCQEC 1031
               G+    C          ++ G C C+E   G +C++C E  F  R+    GC  C
Sbjct: 1093 DLRGTSGDACNLEQGLCGCVEETGACPCKENVFGPQCNECREGTFALRADNPLGCSPC 1150



 Score =  142 bits (357), Expect = 3e-33
 Identities = 95/338 (28%), Positives = 123/338 (36%), Gaps = 128/338 (37%)

Query: 272  SYYYAISDFAVGG---RCKCNGHASECMKNEFDKLVC-NCKHNTYGVDCEKCLPFFNDRP 327
            S YY +     GG    C+C+GHA+EC  +     VC  C HNT GV CE+CLP F   P
Sbjct: 725  SGYYRVDGILFGGICQPCECHGHAAECNVHG----VCIACAHNTTGVHCEQCLPGFYGEP 780

Query: 328  ----------------------------------------------WRRATAES------ 335
                                                          W    A+       
Sbjct: 781  SRGTPGDCQPCACPLTIASNNFSPTCHLNDGDEVVCDWCAPGYSGAWCERCADGYYGNPT 840

Query: 336  --ASECLPCDCNGRSQECYFDPELYRSTGH----GGHCTNCQDNTDGAHCERCRENFFR- 388
                 C+PCDC+G       DP      GH     G C  C  NTDGAHCERC + F+  
Sbjct: 841  VPGESCVPCDCSGN-----VDPS---EAGHCDSVTGECLKCLGNTDGAHCERCADGFYGD 892

Query: 389  -------------------------------------------------LGNNEACSSCH 399
                                                             L +   C  C+
Sbjct: 893  AVTAKNCRACECHVKGSHSAVCHLETGLCDCKPNVTGQQCDQCLHGYYGLDSGHGCRPCN 952

Query: 400  CSPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIE 459
            CS  GS+S  C   G+C C PGV G +CDRC  GF++  +  C PC C  +   + C+ E
Sbjct: 953  CSVAGSVSDGCTDEGQCHCVPGVAGKRCDRCAHGFYAYQDGSCTPCDCPHTQ--NTCDPE 1010

Query: 460  TGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFC 497
            TG CVC  + +G  CE C+ G +  ++    GC  C C
Sbjct: 1011 TGECVCPPHTQGVKCEECEDGHWGYDAE--VGCQACNC 1046



 Score =  136 bits (342), Expect = 2e-31
 Identities = 172/795 (21%), Positives = 303/795 (38%), Gaps = 87/795 (10%)

Query: 795  CPTGTTGKRCELCDDGYF------GDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGE 848
            CP GT G  C+ C  GY       G   G    V  C  C C+++ D      C+  TG+
Sbjct: 1364 CPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSD-----TCDPNTGK 1418

Query: 849  CLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSC---NPVTGQC 905
            CL C  NTAG +CD C  G++G       A  C  C C          +C        +C
Sbjct: 1419 CLNCGDNTAGDHCDVCTSGYYGK--VTGSASDCALCACPHSPPASFSPTCVLEGDHDFRC 1476

Query: 906  E-CLPHVTGQDCGACDPGFY-NLQS-GQGCERCDCHALGSTNGQCDIRTGQCECQPGITG 962
            + CL    G+ C  C   +Y N Q+ G  C++CDC+  GS +G CD  +GQC C+ G +G
Sbjct: 1477 DACLLGYEGKHCERCSSSYYGNPQTPGGSCQKCDCNPHGSVHGDCDRTSGQCVCRLGASG 1536

Query: 963  QHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGRCECREGFVG------NRCDQCE 1016
              C+ CE  H     + C  CD    G L     + G         G            E
Sbjct: 1537 LRCDECEPRHILMETD-CVSCDDECVGVLLNDLDEIGDAVLSLNLTGIIPVPYGILSNLE 1595

Query: 1017 ENYFYNRSWPGCQECPACYRLVKD----KVADHRVKLQELESLIANLGTGDEMVTDQAFE 1072
                Y       QE      + KD    K+     +   L+  +  +    + V ++A E
Sbjct: 1596 NTTKY------LQESLLKENMQKDLGKIKLEGVAEETDNLQKKLTRMLASTQKV-NRATE 1648

Query: 1073 DRLKEAEREVMDLLREAQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGNLAE 1132
               KE++   + + R    + ++ +        +N TL        +    +++ G    
Sbjct: 1649 RIFKESQDLAIAIERLQMSITEIMEK-----TTLNQTLDEDFLLPNSTLQNMQQNGTSLL 1703

Query: 1133 QARAHVENTERLIEIASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQ 1192
            +    + +  +L + A+ EL   K A   +S  Q         + +L E A  +  +H  
Sbjct: 1704 EI-MQIRDFTQLHQNATLEL---KAAEDLLSQIQENYQKPLEELEVLKEAASHVLSKHNN 1759

Query: 1193 EADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAAR 1252
            E      + + A     E+ +LLL  +   N   F  ++L+ + EQ  N++ +L  Q   
Sbjct: 1760 ELKAAEALVREAEAKMQESNHLLL--MVNANLREFSDKKLHVQEEQ--NLTSELIVQGRG 1815

Query: 1253 VHEEAKRAGD---KAVEIYASVAQLSPLDSETLENEANNIKM-----EAENLEQLIDQKL 1304
            + + A    D    A+E          L S  + +  +++ M      A +L    +   
Sbjct: 1816 LIDAAAAQTDAVQDALEHLEDHQDKLLLWSAKIRHHIDDLVMHMSQRNAVDLVYRAEDHA 1875

Query: 1305 KDYEDLREDMRGKELEVKNLLEKGKTEQQTADQLLARADAAKALAEEAAKKGRDTLQEAN 1364
             +++ L + +      ++N+     +       + +  + ++ LA +A +   +T   + 
Sbjct: 1876 AEFQRLADVLYSGLENIRNVSLNATSAAYVHYNIQSLIEESEELARDAHRTVTETSLLSE 1935

Query: 1365 DILNNLKDFDRRVNDNKTAAEEALRKIPAINQTITEANEKTREAQQALGSAAADATEAKN 1424
             +++N K   +R +          RK+P I   ++E   KT   Q+       +A E   
Sbjct: 1936 SLVSNGKAAVQRSSRFLKEGNNLSRKLPGIALELSELRNKTNRFQE-------NAVEITR 1988

Query: 1425 KAHEAERIASAVQKN-----------ATSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEK 1473
            + +E+  I  A+ K            ATS    A  T  +V  L  E+ N    L     
Sbjct: 1989 QTNESLLILRAIPKGIRDKGAKTKELATSASQSAVSTLRDVAGLSQELLNTSASLSRVNT 2048

Query: 1474 ELKRKQDDADQDMMMAGMASQAAQEAEINARKAKNSVTSLLSIINDLLEQLGQLDTVDLN 1533
             L+          M   +A +  ++ EI A           +++ D L+ L  L+     
Sbjct: 2049 TLRETHQLLQDSTMATLLAGRKVKDVEIQA-----------NLLFDRLKPLKMLEENLSR 2097

Query: 1534 KLNEIEGTLNKAKDE 1548
             L+EI+  +++A+ +
Sbjct: 2098 NLSEIKLLISQARKQ 2112



 Score =  111 bits (277), Expect = 6e-24
 Identities = 70/233 (30%), Positives = 102/233 (43%), Gaps = 32/233 (13%)

Query: 305  CNCKHNTYGVDCEKCLPFFNDRPWR----RATAESASECLPCDCNGRSQECYFDPELYRS 360
            C C   T G  C+ C P ++         R      + C+PC CN  S  C  DP     
Sbjct: 1362 CVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTC--DPNT--- 1416

Query: 361  TGHGGHCTNCQDNTDGAHCERCRENFFR--LGNNEACSSCHC--SPVGSLSTQC----DS 412
                G C NC DNT G HC+ C   ++    G+   C+ C C  SP  S S  C    D 
Sbjct: 1417 ----GKCLNCGDNTAGDHCDVCTSGYYGKVTGSASDCALCACPHSPPASFSPTCVLEGDH 1472

Query: 413  YGRC-SCKPGVMGDKCDRCQPGFHSLTE---AGCRPCSCDPSGSI-DECNIETGRCVCKD 467
              RC +C  G  G  C+RC   ++   +     C+ C C+P GS+  +C+  +G+CVC+ 
Sbjct: 1473 DFRCDACLLGYEGKHCERCSSSYYGNPQTPGGSCQKCDCNPHGSVHGDCDRTSGQCVCRL 1532

Query: 468  NVEGFNCERCKPGFFNLESSNPRGCTPC--FCFGHSSVCTNAVGYSVYSISST 518
               G  C+ C+P    +E+     C  C   C G      + +G +V S++ T
Sbjct: 1533 GASGLRCDECEPRHILMETD----CVSCDDECVGVLLNDLDEIGDAVLSLNLT 1581



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 62/191 (32%), Positives = 83/191 (43%), Gaps = 16/191 (8%)

Query: 286  CKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCN 345
            C CN H+  C  N    L  NC  NT G  C+ C   +  +        SAS+C  C C 
Sbjct: 1403 CSCNNHSDTCDPNTGKCL--NCGDNTAGDHCDVCTSGYYGK-----VTGSASDCALCAC- 1454

Query: 346  GRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNE----ACSSCHCS 401
              S    F P       H   C  C    +G HCERC  +++  GN +    +C  C C+
Sbjct: 1455 PHSPPASFSPTCVLEGDHDFRCDACLLGYEGKHCERCSSSYY--GNPQTPGGSCQKCDCN 1512

Query: 402  PVGSLSTQCD-SYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIET 460
            P GS+   CD + G+C C+ G  G +CD C+P  H L E  C  C  +  G +     E 
Sbjct: 1513 PHGSVHGDCDRTSGQCVCRLGASGLRCDECEPR-HILMETDCVSCDDECVGVLLNDLDEI 1571

Query: 461  GRCVCKDNVEG 471
            G  V   N+ G
Sbjct: 1572 GDAVLSLNLTG 1582



 Score = 85.5 bits (210), Expect = 4e-16
 Identities = 152/778 (19%), Positives = 286/778 (36%), Gaps = 125/778 (16%)

Query: 905  CECLPHVTGQDCGACDPGFYNLQSGQGCER-----------CDCHALGSTNGQCDIRTGQ 953
            C C P   G  C  C PG++  +   G +R           C C+    T   CD  TG+
Sbjct: 1362 CVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDT---CDPNTGK 1418

Query: 954  C-ECQPGITGQHCERCEVNHFG---FGPEGCKPCDC--HPEGSLSLQCKDDG----RCE- 1002
            C  C     G HC+ C   ++G        C  C C   P  S S  C  +G    RC+ 
Sbjct: 1419 CLNCGDNTAGDHCDVCTSGYYGKVTGSASDCALCACPHSPPASFSPTCVLEGDHDFRCDA 1478

Query: 1003 CREGFVGNRCDQCEENYFYNRSWPG--CQECPA---------CYRLVKD---KVADHRVK 1048
            C  G+ G  C++C  +Y+ N   PG  CQ+C           C R       ++    ++
Sbjct: 1479 CLLGYEGKHCERCSSSYYGNPQTPGGSCQKCDCNPHGSVHGDCDRTSGQCVCRLGASGLR 1538

Query: 1049 LQELESLIANLGTGDEMVTDQAFEDRLKEAEREVMD--LLREAQDVKDVDQNLMDRLQRV 1106
              E E     + T      D+     L + + E+ D  L      +  V   ++  L+  
Sbjct: 1539 CDECEPRHILMETDCVSCDDECVGVLLNDLD-EIGDAVLSLNLTGIIPVPYGILSNLENT 1597

Query: 1107 NNTLSSQISRLQ--------NIRNTIEETGNLAEQARAHVENTERLIEIASRELEKAKVA 1158
               L   + +           +    EET NL ++    + +T+++     R  ++++  
Sbjct: 1598 TKYLQESLLKENMQKDLGKIKLEGVAEETDNLQKKLTRMLASTQKVNRATERIFKESQDL 1657

Query: 1159 AANVSVTQPESTGDPNNMTL---LAEE---ARKLAERHKQEADDIVRVAKTANDTSTEAY 1212
            A  +   Q   T      TL   L E+        +  +Q    ++ + +  + T     
Sbjct: 1658 AIAIERLQMSITEIMEKTTLNQTLDEDFLLPNSTLQNMQQNGTSLLEIMQIRDFTQLH-Q 1716

Query: 1213 NLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVA 1272
            N  L   A E+  +   E   +  E+ + + +      ++ + E K A            
Sbjct: 1717 NATLELKAAEDLLSQIQENYQKPLEELEVLKEAASHVLSKHNNELKAA------------ 1764

Query: 1273 QLSPLDSETLENEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQ 1332
                   E L  EA     E+ +L  +++  L+++ D +  ++ ++     L+ +G+   
Sbjct: 1765 -------EALVREAEAKMQESNHLLLMVNANLREFSDKKLHVQEEQNLTSELIVQGR--- 1814

Query: 1333 QTADQLLARADAAKALAEEAAKKGRDTLQEANDILNNLKDF-----DRRVNDNKTAAEEA 1387
               D   A+ DA +   E         L  +  I +++ D       R   D    AE+ 
Sbjct: 1815 GLIDAAAAQTDAVQDALEHLEDHQDKLLLWSAKIRHHIDDLVMHMSQRNAVDLVYRAEDH 1874

Query: 1388 LRKIPAINQTITEANEKTREAQQALGSAAADATEAKNKAHEAERIASAVQKNATSTKAEA 1447
              +   +   +    E  R       SAA      ++   E+E +A    +  T T   +
Sbjct: 1875 AAEFQRLADVLYSGLENIRNVSLNATSAAYVHYNIQSLIEESEELARDAHRTVTETSLLS 1934

Query: 1448 E--------------RTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDA-------DQDM 1486
            E              R   E  +L  ++  +  +L E   +  R Q++A       ++ +
Sbjct: 1935 ESLVSNGKAAVQRSSRFLKEGNNLSRKLPGIALELSELRNKTNRFQENAVEITRQTNESL 1994

Query: 1487 MM-----AGMASQAAQEAEINARKAKNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGT 1541
            ++      G+  + A+  E+ A  A  S  S L  +  L ++L  L+T     L+ +  T
Sbjct: 1995 LILRAIPKGIRDKGAKTKEL-ATSASQSAVSTLRDVAGLSQEL--LNT--SASLSRVNTT 2049

Query: 1542 LNKAKDEMKVSDL-----DRKVSDLENEAKKQEAAIMDYNRDIEEIMKDI-RNLEDIR 1593
            L +    ++ S +      RKV D+E +A      + D  + ++ + +++ RNL +I+
Sbjct: 2050 LRETHQLLQDSTMATLLAGRKVKDVEIQAN----LLFDRLKPLKMLEENLSRNLSEIK 2103



 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 38/124 (30%), Positives = 51/124 (41%), Gaps = 24/124 (19%)

Query: 954  CECQPGITGQHCERC-----EVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGRC-ECREGF 1007
            CEC  G TG  CE C      V+   FG   C+PC+CH   +   +C   G C  C    
Sbjct: 709  CECPQGYTGTSCESCLSGYYRVDGILFGGI-CQPCECHGHAA---ECNVHGVCIACAHNT 764

Query: 1008 VGNRCDQCEENYF--YNRSWPG-CQECPACYRLVKDKVADHRVKLQELESLIANLGTGDE 1064
             G  C+QC   ++   +R  PG CQ C     +  +             S   +L  GDE
Sbjct: 765  TGVHCEQCLPGFYGEPSRGTPGDCQPCACPLTIASNNF-----------SPTCHLNDGDE 813

Query: 1065 MVTD 1068
            +V D
Sbjct: 814  VVCD 817


>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
            sapiens]
          Length = 3118

 Score =  620 bits (1598), Expect = e-177
 Identities = 378/1086 (34%), Positives = 543/1086 (50%), Gaps = 108/1086 (9%)

Query: 20   VLAVLAAAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFNVTVVATNTCGTP-PEEYCV 78
            +L +L+       AQ    +   +  + +   P  +N A N  +    TCG   PE YC 
Sbjct: 9    LLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCGEKGPEMYCK 68

Query: 79   QT----GVTGVTKSCHLCD--AGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQYPSS 132
                  G       C +C+  +  P+ +H      D  N    TWWQS ++  G++Y   
Sbjct: 69   LVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNAIDGKN----TWWQSPSIKNGIEY-HY 123

Query: 133  INLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGS---CENTYSKA 189
            + +TL L + F I YV +K   S      I +R+ +D  + P+QY++ +   C   Y+  
Sbjct: 124  VTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLYNIY 183

Query: 190  NRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDI 249
             R    +   + + +CT  +S I PL  G +  S + GRPSA   D SP L E+ +A  I
Sbjct: 184  PRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSAD--DPSPELLEFTSARYI 241

Query: 250  RVTLNRLNTFGDEVFN---------DPKVLKSYYYAISDFAVGGRCKCNGHASEC-MKNE 299
            R+   R+ T   ++           DP V + YYY++ D +VGG C C GHA  C +   
Sbjct: 242  RLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPA 301

Query: 300  FDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYR 359
             +K  C C+HNT G  C++C P F+ +PWR  T  + +EC  C+C+G+++ECY+D  + R
Sbjct: 302  TNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVAR 361

Query: 360  STGH---------GGHCTNCQDNTDGAHCERCRENFFR---LGNN--EACSSCHCSPVGS 405
                         GG C NC  NT G +CE C + FFR   +  N    C  CHC P+GS
Sbjct: 362  RNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGS 421

Query: 406  LSTQCD----------SYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDE 455
            L+  C           + G C CK G  G  CDRC  G+    +  C+ C+C   GS +E
Sbjct: 422  LNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPD--CKACNCSGLGSKNE 479

Query: 456  CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGY--SVY 513
             +   G C+CK+NVEG +C RCK GFFNL+  N +GC  CFC G S+ C ++      + 
Sbjct: 480  -DPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQ 538

Query: 514  SISSTFQIDEDG--WRAEQRDGSEASLEWS-SERQDIAVISDSYFPRYFIAPAKFLGKQV 570
             +S  +  D  G    A Q+D  ++  + S S  +    +  SY   Y+ APA +LG ++
Sbjct: 539  DMSGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSY---YWSAPAPYLGNKL 595

Query: 571  LSYGQNLSFSFRVDRRDTRLSAED-----LVLEGAGLRVSVPLIAQGNSY--PSETTVKY 623
             + G  L+F+   D  +     E      ++LEG  L +S    AQ   Y  PSE     
Sbjct: 596  PAVGGQLTFTISYDLEEEEEDTERVLQLMIILEGNDLSIST---AQDEVYLHPSEEHTNV 652

Query: 624  V------FRLHEATDYPWRPALTPFEFQKLLNNLTSIKIRGTYS--ERSAGYLDDVTLAS 675
            +      F +H  T +P R      EF  +L NL  + ++ TYS    +   L  V L S
Sbjct: 653  LLLKEESFTIH-GTHFPVRRK----EFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLES 707

Query: 676  A--RPGPGVPATWVESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETC 733
            A   P  G  A  VE C CP GY G  CE C   +RR    +     C  C C GH+E+C
Sbjct: 708  AVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFG-GICEPCQCFGHAESC 766

Query: 734  DPETGVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCP------GGSSCAVVPK 786
            D  TG C NC+D+T GP+C+KC  G+YG+ T GTS DCQPC CP        S    + +
Sbjct: 767  DDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDR 826

Query: 787  TKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLT 846
            +  ++C  CP G TG RCE C +GYFG P   + P   C+ CQC+DN+D +  G+C+ L+
Sbjct: 827  SLGLICDGCPVGYTGPRCERCAEGYFGQP---SVPGGSCQPCQCNDNLDFSIPGSCDSLS 883

Query: 847  GECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCE 906
            G CL C   T G YC+ C DG+FG+ +    A  C+ C CN  G+  +   C+  TGQCE
Sbjct: 884  GSCLICKPGTTGRYCELCADGYFGDAV---DAKNCQPCRCNAGGSFSE--VCHSQTGQCE 938

Query: 907  CLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCE 966
            C  +V GQ C  C  G + LQS +GC  C+C++ GS +  C+  +GQC CQPG+TG+ C+
Sbjct: 939  CRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCE-ESGQCWCQPGVTGKKCD 997

Query: 967  RCEVNHFGFGPEGCKPCDCHPEGSLSLQC-KDDGRCECREGFVGNRCDQCEENYFYNRSW 1025
            RC   +F F   GC  C+C   G+    C    GRC C    +G +C +C  N + +   
Sbjct: 998  RCAHGYFNFQEGGCTACECSHLGN---NCDPKTGRCICPPNTIGEKCSKCAPNTWGHSIT 1054

Query: 1026 PGCQEC 1031
             GC+ C
Sbjct: 1055 TGCKAC 1060



 Score =  286 bits (731), Expect = 1e-76
 Identities = 199/665 (29%), Positives = 290/665 (43%), Gaps = 106/665 (15%)

Query: 285  RCKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRAT--AESASECLPC 342
            RC   G  SE   ++  +  C C+ N  G  C+KC         +  T   +SA  C+PC
Sbjct: 919  RCNAGGSFSEVCHSQTGQ--CECRANVQGQRCDKC---------KAGTFGLQSARGCVPC 967

Query: 343  DCNG---------RSQECYFDPELYRST----GHG------GHCTNCQ------------ 371
            +CN           S +C+  P +         HG      G CT C+            
Sbjct: 968  NCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLGNNCDPKT 1027

Query: 372  ------DNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCD-SYGRCSCKPGVMG 424
                   NT G  C +C  N +       C +C+CS VGSL  QC+ + G+C+C P   G
Sbjct: 1028 GRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSG 1087

Query: 425  DKCDRCQPGFHSLTEAGCRPC--------SCDPSGSIDECNIETGRCVCKDNVEGFNCER 476
             KC  C  G  +        C        +CD       C+ +TG+C CK NVEG +C+R
Sbjct: 1088 AKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDR 1147

Query: 477  CKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGY-----SVYSISSTFQIDEDGWRAEQR 531
            C+PG F L++ NP GC+ C+CFG ++ C+ A G      ++ +  +   + ++  +    
Sbjct: 1148 CRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDEALQHTTT 1207

Query: 532  DGSEASLEWSSERQDIAVISDSYFPRYFIAPAKFLGKQVLSYGQNLSFSFRVD-RRDTRL 590
             G            D+        P Y+  P +F GK++++YG  L ++   + R +T  
Sbjct: 1208 KGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFEAREETGF 1267

Query: 591  SAED--LVLEGAG--------LRVSVPLIAQGNSYPSETTVKYVFRLHEATDYPWRPALT 640
            S  +  +++ G            ++ PLI Q   +  E T K     +   D      +T
Sbjct: 1268 STYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEW--KYYGDDPRVHRTVT 1325

Query: 641  PFEFQKLLNNLTSIKIRGTYSE-RSAGYLDDVTLASARPGPGV----PATWVESCTCPVG 695
              +F  +L ++  I I+ TY        + ++++  A  G G     PA  +E C CP+G
Sbjct: 1326 REDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEKCDCPLG 1385

Query: 696  YGGQFCEMCLSGYRRETPNLGPYSP------CVLCACNGHSETCDPETGVC-NCRDNTAG 748
            Y G  CE CL G+ R     G  +P      CV C CNGHS  CDPET +C NC+ +TAG
Sbjct: 1386 YSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQHHTAG 1445

Query: 749  PHCEKCSDGYYGDSTAGTSSDCQPCPCP------GGSSCAVVPKTKEVVCTNCPTGTTGK 802
              CE+C+ GYYG    G  +DCQ C CP        S   V     +  CT CP G  G+
Sbjct: 1446 DFCERCALGYYG-IVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQ 1504

Query: 803  RCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDP--NAVGNCNRLTGECLKCIYNTAGFY 860
             CE C  GY G P     P   C+ C+C    DP  +    C+ +TG C  C     G  
Sbjct: 1505 YCERCAPGYTGSP---GNPGGSCQECEC----DPYGSLPVPCDPVTGFC-TCRPGATGRK 1556

Query: 861  CDRCK 865
            CD CK
Sbjct: 1557 CDGCK 1561



 Score =  180 bits (456), Expect = 1e-44
 Identities = 109/319 (34%), Positives = 141/319 (44%), Gaps = 39/319 (12%)

Query: 680  PGVPATWVESCT-CPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETG 738
            PG   +   SC  C  G  G++CE+C  GY  +  +     PC   A    SE C  +TG
Sbjct: 876  PGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTG 935

Query: 739  VCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTG 798
             C CR N  G  C+KC  G +G  +A     C PC C    S +     +E     C  G
Sbjct: 936  QCECRANVQGQRCDKCKAGTFGLQSA---RGCVPCNCNSFGSKSF--DCEESGQCWCQPG 990

Query: 799  TTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAG 858
             TGK+C+ C  GYF    G       C  C+CS     +   NC+  TG C+ C  NT G
Sbjct: 991  VTGKKCDRCAHGYFNFQEGG------CTACECS-----HLGNNCDPKTGRCI-CPPNTIG 1038

Query: 859  FYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGA 918
              C +C    +G+ +       CKACNC+  G++  Q  CN  TGQC C P  +G  C  
Sbjct: 1039 EKCSKCAPNTWGHSITTG----CKACNCSTVGSLDFQ--CNVNTGQCNCHPKFSGAKCTE 1092

Query: 919  CDPGFYNLQSGQGCERCDCHALGSTNGQCDI---------RTGQCECQPGITGQHCERCE 969
            C  G +N      C  CDC   G+    CD          +TGQC C+  + G HC+RC 
Sbjct: 1093 CSRGHWNYPR---CNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCR 1149

Query: 970  VNHFGF---GPEGCKPCDC 985
               FG     P GC  C C
Sbjct: 1150 PGKFGLDAKNPLGCSSCYC 1168



 Score =  149 bits (377), Expect = 2e-35
 Identities = 197/870 (22%), Positives = 350/870 (40%), Gaps = 151/870 (17%)

Query: 778  GSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYF---GDPLGRN-GP-VRLCRLCQCSD 832
            G    + P    +   +CP G +G  CE C  G++     P GR  GP +  C  CQC+ 
Sbjct: 1365 GRGTTMTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNG 1424

Query: 833  NIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTM 892
            +        C+  T  C  C ++TAG +C+RC  G++G  +     + C+ C C L  + 
Sbjct: 1425 HSSL-----CDPETSICQNCQHHTAGDFCERCALGYYG--IVKGLPNDCQQCACPLISSS 1477

Query: 893  KQQSSCNPVTG----QCECLPH-VTGQDCGACDPGFYNLQSGQG--CERCDCHALGSTNG 945
               S      G    +C   P    GQ C  C PG+       G  C+ C+C   GS   
Sbjct: 1478 NNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPV 1537

Query: 946  QCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGRCECRE 1005
             CD  TG C C+PG TG+ C+ C+  H               EG   + C D    EC  
Sbjct: 1538 PCDPVTGFCTCRPGATGRKCDGCKHWH-------------AREGWECVFCGD----ECTG 1580

Query: 1006 GFVGNRCDQCEENYFYNRSWPGCQECPACYRLV---------------KDKVADHRVKLQ 1050
              +G+     +     N + P     PA Y+++                 +  +  ++L 
Sbjct: 1581 LLLGDLARLEQMVMSINLTGP----LPAPYKMLYGLENMTQELKHLLSPQRAPERLIQLA 1636

Query: 1051 E--LESLIANLG---------TGDEMVTDQAFE---DRLKEAEREVMDLLREAQDVKDVD 1096
            E  L +L+  +          T D   T Q  E    R K     + +L R+A+ V    
Sbjct: 1637 EGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVN--- 1693

Query: 1097 QNLMDRLQRVNNTLSSQISRLQ-NIRNTIEETGNLAEQARAHVENTERLIEIASRELEKA 1155
                ++  ++N TL ++    + N+    +E   + ++ R   +N E   EIA  EL  A
Sbjct: 1694 ----EKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRR--KNLETQKEIAEDELVAA 1747

Query: 1156 KVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLL 1215
            +     V     ES G+   M    ++ R+    +K + DD   + + A D   EA  L 
Sbjct: 1748 EALLKKVKKLFGESRGENEEM---EKDLREKLADYKNKVDDAWDLLREATDKIREANRLF 1804

Query: 1216 LRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLS 1275
               +  +N TA  +E+     E  K   ++  K+   + +EA R  D             
Sbjct: 1805 --AVNQKNMTA--LEKKKEAVESGKRQIENTLKEGNDILDEANRLAD------------- 1847

Query: 1276 PLDSETLENEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQQTA 1335
                     E N+I    E+++  +    ++  D  +D+  +E++ + L EK    +  A
Sbjct: 1848 ---------EINSIIDYVEDIQTKLPPMSEELNDKIDDL-SQEIKDRKLAEKVSQAESHA 1897

Query: 1336 DQLLARADAAKALAEEAAKKGRDTLQEANDILNNLKDFDRRVNDNKTAAEEALRKIPAIN 1395
             Q                      L +++ +L+ + D  + ++ N TAA +A      I 
Sbjct: 1898 AQ----------------------LNDSSAVLDGILDEAKNISFNATAAFKAYSN---IK 1932

Query: 1396 QTITEANEKTREAQQALGSAAADATEAKNKAHEAERIASAVQKNATSTKAEAERTFAEVT 1455
              I EA +  +EA+     A   AT  +    E  +    +QK+      EA++   +V 
Sbjct: 1933 DYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAK--GCLQKSFRILN-EAKKLANDVK 1989

Query: 1456 DLDNEVNNMLKQLQEAEKE----LKRKQDDADQDMMMAGMASQAAQEAEINARKAKNSVT 1511
            + ++ +N +  +++ A+      L+   D   +   +    +   Q  +  AR+A ++  
Sbjct: 1990 ENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKDKARQANDTAK 2049

Query: 1512 SLLSIINDLLEQLGQLDTVDLNKL-NEIEGTLNKAKDEMK---VSDLDRKVSDLENEAKK 1567
             +L+ I +L + L  L   + NKL + +  T    KD  K   ++D D  V +LE EA +
Sbjct: 2050 DVLAQITELHQNLDGLKK-NYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLEQEADR 2108

Query: 1568 QEAAIMDYNRDIEEIMKDI-RNLEDIRKTL 1596
                ++D  + I+E+  ++ +N+ +I++ +
Sbjct: 2109 ----LIDKLKPIKELEDNLKKNISEIKELI 2134



 Score =  134 bits (337), Expect = 7e-31
 Identities = 73/216 (33%), Positives = 97/216 (44%), Gaps = 22/216 (10%)

Query: 286  CKCNGHASECMKNEFDKLVCNC---KHNTYGVDCEKCLP-FFNDRPWRRATAESASECLP 341
            C+CN +    +    D L  +C   K  T G  CE C   +F D       A  A  C P
Sbjct: 865  CQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGD-------AVDAKNCQP 917

Query: 342  CDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCS 401
            C CN       F    +  TG       C+ N  G  C++C+   F L +   C  C+C+
Sbjct: 918  CRCNAGGS---FSEVCHSQTGQ----CECRANVQGQRCDKCKAGTFGLQSARGCVPCNCN 970

Query: 402  PVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIETG 461
              GS S  C+  G+C C+PGV G KCDRC  G+ +  E GC  C C   G  + C+ +TG
Sbjct: 971  SFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLG--NNCDPKTG 1028

Query: 462  RCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFC 497
            RC+C  N  G  C +C P  +    S   GC  C C
Sbjct: 1029 RCICPPNTIGEKCSKCAPNTWG--HSITTGCKACNC 1062



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 74/347 (21%), Positives = 148/347 (42%), Gaps = 40/347 (11%)

Query: 1040 DKVADHRVKLQEL-ESLIANLGTGDEMVTDQAFEDRLKEAEREVMDLLREAQDVKDVDQN 1098
            D V D + KL  + E L   +    + + D+   +++ +AE     L     D   V   
Sbjct: 1854 DYVEDIQTKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQL----NDSSAVLDG 1909

Query: 1099 LMDRLQRVNNTLSSQISRLQNIRNTIEETGNLAEQAR--AHVENTERLIEIASRELEKAK 1156
            ++D  + ++   ++      NI++ I+E   +A++A+  AH               E  K
Sbjct: 1910 ILDEAKNISFNATAAFKAYSNIKDYIDEAEKVAKEAKDLAH---------------EATK 1954

Query: 1157 VAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLLL 1216
            +A     + + ++ G       +  EA+KLA   K E +D +   KT  + +      LL
Sbjct: 1955 LATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVK-ENEDHLNGLKTRIENADARNGDLL 2013

Query: 1217 RTL--------AGENQTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIY 1268
            RTL        A  N TA +++ +  K  QA + ++D+  Q   +H+          ++ 
Sbjct: 2014 RTLNDTLGKLSAIPNDTAAKLQAVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNKLA 2073

Query: 1269 ASVAQLSPLDSETLENEA-NNIKMEAENLEQLIDQ---KLKDYEDLREDMRGKELEVKNL 1324
             SVA+ + +  +  +N+   +     +NLEQ  D+   KLK  ++L ++++    E+K L
Sbjct: 2074 DSVAKTNAVVKDPSKNKIIADADATVKNLEQEADRLIDKLKPIKELEDNLKKNISEIKEL 2133

Query: 1325 LEKGKTEQQTADQLLARADAAKALAEEAAKKGRDTLQEANDILNNLK 1371
            + + + +  +    ++         +   KKG       N+I+ N+K
Sbjct: 2134 INQARKQANSIKVSVSSGGDCIRTYKPEIKKG-----SYNNIVVNVK 2175



 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 30/99 (30%), Positives = 41/99 (41%), Gaps = 11/99 (11%)

Query: 943  TNGQCDIRTGQCECQPGITGQHCERC-----EVNHFGFGPEGCKPCDCHPEGSLSLQCKD 997
            T+G        C+C PG TG  CE C      VN   FG   C+PC C         C D
Sbjct: 713  TDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGI-CEPCQCFGHAE---SCDD 768

Query: 998  -DGRC-ECREGFVGNRCDQCEENYFYNRSWPGCQECPAC 1034
              G C  C++   G  CD+C   ++   +    ++C  C
Sbjct: 769  VTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPC 807



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 51/229 (22%), Positives = 97/229 (42%), Gaps = 30/229 (13%)

Query: 1391 IPAINQTITEANEKTREAQQALGSAAADATEAKNKAH---EAERIASAVQKNA---TSTK 1444
            +  +N+ +T A + T + +Q    A    T AK+      E  R A AV + A     T 
Sbjct: 1644 VTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLNETL 1703

Query: 1445 AEAERTFAE-VTDLDNEVNNMLKQLQEAEKELKRKQDDADQDMMMA-----------GMA 1492
               +  F   +  L  E++ M+K+L+   K L+ +++ A+ +++ A           G +
Sbjct: 1704 GTRDEAFERNLEGLQKEIDQMIKELRR--KNLETQKEIAEDELVAAEALLKKVKKLFGES 1761

Query: 1493 SQAAQEAEINARKA----KNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDE 1548
                +E E + R+     KN V     ++ +  +++ +      N+L  +    N    E
Sbjct: 1762 RGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREA-----NRLFAVNQK-NMTALE 1815

Query: 1549 MKVSDLDRKVSDLENEAKKQEAAIMDYNRDIEEIMKDIRNLEDIRKTLP 1597
             K   ++     +EN  K+    + + NR  +EI   I  +EDI+  LP
Sbjct: 1816 KKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLP 1864


>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
            sapiens]
          Length = 3122

 Score =  620 bits (1598), Expect = e-177
 Identities = 378/1086 (34%), Positives = 543/1086 (50%), Gaps = 108/1086 (9%)

Query: 20   VLAVLAAAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFNVTVVATNTCGTP-PEEYCV 78
            +L +L+       AQ    +   +  + +   P  +N A N  +    TCG   PE YC 
Sbjct: 9    LLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCGEKGPEMYCK 68

Query: 79   QT----GVTGVTKSCHLCD--AGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQYPSS 132
                  G       C +C+  +  P+ +H      D  N    TWWQS ++  G++Y   
Sbjct: 69   LVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNAIDGKN----TWWQSPSIKNGIEY-HY 123

Query: 133  INLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGS---CENTYSKA 189
            + +TL L + F I YV +K   S      I +R+ +D  + P+QY++ +   C   Y+  
Sbjct: 124  VTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLYNIY 183

Query: 190  NRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDI 249
             R    +   + + +CT  +S I PL  G +  S + GRPSA   D SP L E+ +A  I
Sbjct: 184  PRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSAD--DPSPELLEFTSARYI 241

Query: 250  RVTLNRLNTFGDEVFN---------DPKVLKSYYYAISDFAVGGRCKCNGHASEC-MKNE 299
            R+   R+ T   ++           DP V + YYY++ D +VGG C C GHA  C +   
Sbjct: 242  RLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPA 301

Query: 300  FDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYR 359
             +K  C C+HNT G  C++C P F+ +PWR  T  + +EC  C+C+G+++ECY+D  + R
Sbjct: 302  TNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVAR 361

Query: 360  STGH---------GGHCTNCQDNTDGAHCERCRENFFR---LGNN--EACSSCHCSPVGS 405
                         GG C NC  NT G +CE C + FFR   +  N    C  CHC P+GS
Sbjct: 362  RNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGS 421

Query: 406  LSTQCD----------SYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDE 455
            L+  C           + G C CK G  G  CDRC  G+    +  C+ C+C   GS +E
Sbjct: 422  LNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPD--CKACNCSGLGSKNE 479

Query: 456  CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGY--SVY 513
             +   G C+CK+NVEG +C RCK GFFNL+  N +GC  CFC G S+ C ++      + 
Sbjct: 480  -DPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQ 538

Query: 514  SISSTFQIDEDG--WRAEQRDGSEASLEWS-SERQDIAVISDSYFPRYFIAPAKFLGKQV 570
             +S  +  D  G    A Q+D  ++  + S S  +    +  SY   Y+ APA +LG ++
Sbjct: 539  DMSGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSY---YWSAPAPYLGNKL 595

Query: 571  LSYGQNLSFSFRVDRRDTRLSAED-----LVLEGAGLRVSVPLIAQGNSY--PSETTVKY 623
             + G  L+F+   D  +     E      ++LEG  L +S    AQ   Y  PSE     
Sbjct: 596  PAVGGQLTFTISYDLEEEEEDTERVLQLMIILEGNDLSIST---AQDEVYLHPSEEHTNV 652

Query: 624  V------FRLHEATDYPWRPALTPFEFQKLLNNLTSIKIRGTYS--ERSAGYLDDVTLAS 675
            +      F +H  T +P R      EF  +L NL  + ++ TYS    +   L  V L S
Sbjct: 653  LLLKEESFTIH-GTHFPVRRK----EFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLES 707

Query: 676  A--RPGPGVPATWVESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETC 733
            A   P  G  A  VE C CP GY G  CE C   +RR    +     C  C C GH+E+C
Sbjct: 708  AVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFG-GICEPCQCFGHAESC 766

Query: 734  DPETGVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCP------GGSSCAVVPK 786
            D  TG C NC+D+T GP+C+KC  G+YG+ T GTS DCQPC CP        S    + +
Sbjct: 767  DDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDR 826

Query: 787  TKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLT 846
            +  ++C  CP G TG RCE C +GYFG P   + P   C+ CQC+DN+D +  G+C+ L+
Sbjct: 827  SLGLICDGCPVGYTGPRCERCAEGYFGQP---SVPGGSCQPCQCNDNLDFSIPGSCDSLS 883

Query: 847  GECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCE 906
            G CL C   T G YC+ C DG+FG+ +    A  C+ C CN  G+  +   C+  TGQCE
Sbjct: 884  GSCLICKPGTTGRYCELCADGYFGDAV---DAKNCQPCRCNAGGSFSE--VCHSQTGQCE 938

Query: 907  CLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCE 966
            C  +V GQ C  C  G + LQS +GC  C+C++ GS +  C+  +GQC CQPG+TG+ C+
Sbjct: 939  CRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCE-ESGQCWCQPGVTGKKCD 997

Query: 967  RCEVNHFGFGPEGCKPCDCHPEGSLSLQC-KDDGRCECREGFVGNRCDQCEENYFYNRSW 1025
            RC   +F F   GC  C+C   G+    C    GRC C    +G +C +C  N + +   
Sbjct: 998  RCAHGYFNFQEGGCTACECSHLGN---NCDPKTGRCICPPNTIGEKCSKCAPNTWGHSIT 1054

Query: 1026 PGCQEC 1031
             GC+ C
Sbjct: 1055 TGCKAC 1060



 Score =  286 bits (731), Expect = 1e-76
 Identities = 199/665 (29%), Positives = 290/665 (43%), Gaps = 106/665 (15%)

Query: 285  RCKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRAT--AESASECLPC 342
            RC   G  SE   ++  +  C C+ N  G  C+KC         +  T   +SA  C+PC
Sbjct: 919  RCNAGGSFSEVCHSQTGQ--CECRANVQGQRCDKC---------KAGTFGLQSARGCVPC 967

Query: 343  DCNG---------RSQECYFDPELYRST----GHG------GHCTNCQ------------ 371
            +CN           S +C+  P +         HG      G CT C+            
Sbjct: 968  NCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLGNNCDPKT 1027

Query: 372  ------DNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCD-SYGRCSCKPGVMG 424
                   NT G  C +C  N +       C +C+CS VGSL  QC+ + G+C+C P   G
Sbjct: 1028 GRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSG 1087

Query: 425  DKCDRCQPGFHSLTEAGCRPC--------SCDPSGSIDECNIETGRCVCKDNVEGFNCER 476
             KC  C  G  +        C        +CD       C+ +TG+C CK NVEG +C+R
Sbjct: 1088 AKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDR 1147

Query: 477  CKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGY-----SVYSISSTFQIDEDGWRAEQR 531
            C+PG F L++ NP GC+ C+CFG ++ C+ A G      ++ +  +   + ++  +    
Sbjct: 1148 CRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDEALQHTTT 1207

Query: 532  DGSEASLEWSSERQDIAVISDSYFPRYFIAPAKFLGKQVLSYGQNLSFSFRVD-RRDTRL 590
             G            D+        P Y+  P +F GK++++YG  L ++   + R +T  
Sbjct: 1208 KGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFEAREETGF 1267

Query: 591  SAED--LVLEGAG--------LRVSVPLIAQGNSYPSETTVKYVFRLHEATDYPWRPALT 640
            S  +  +++ G            ++ PLI Q   +  E T K     +   D      +T
Sbjct: 1268 STYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEW--KYYGDDPRVHRTVT 1325

Query: 641  PFEFQKLLNNLTSIKIRGTYSE-RSAGYLDDVTLASARPGPGV----PATWVESCTCPVG 695
              +F  +L ++  I I+ TY        + ++++  A  G G     PA  +E C CP+G
Sbjct: 1326 REDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEKCDCPLG 1385

Query: 696  YGGQFCEMCLSGYRRETPNLGPYSP------CVLCACNGHSETCDPETGVC-NCRDNTAG 748
            Y G  CE CL G+ R     G  +P      CV C CNGHS  CDPET +C NC+ +TAG
Sbjct: 1386 YSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQHHTAG 1445

Query: 749  PHCEKCSDGYYGDSTAGTSSDCQPCPCP------GGSSCAVVPKTKEVVCTNCPTGTTGK 802
              CE+C+ GYYG    G  +DCQ C CP        S   V     +  CT CP G  G+
Sbjct: 1446 DFCERCALGYYG-IVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQ 1504

Query: 803  RCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDP--NAVGNCNRLTGECLKCIYNTAGFY 860
             CE C  GY G P     P   C+ C+C    DP  +    C+ +TG C  C     G  
Sbjct: 1505 YCERCAPGYTGSP---GNPGGSCQECEC----DPYGSLPVPCDPVTGFC-TCRPGATGRK 1556

Query: 861  CDRCK 865
            CD CK
Sbjct: 1557 CDGCK 1561



 Score =  180 bits (456), Expect = 1e-44
 Identities = 109/319 (34%), Positives = 141/319 (44%), Gaps = 39/319 (12%)

Query: 680  PGVPATWVESCT-CPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETG 738
            PG   +   SC  C  G  G++CE+C  GY  +  +     PC   A    SE C  +TG
Sbjct: 876  PGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTG 935

Query: 739  VCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTG 798
             C CR N  G  C+KC  G +G  +A     C PC C    S +     +E     C  G
Sbjct: 936  QCECRANVQGQRCDKCKAGTFGLQSA---RGCVPCNCNSFGSKSF--DCEESGQCWCQPG 990

Query: 799  TTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAG 858
             TGK+C+ C  GYF    G       C  C+CS     +   NC+  TG C+ C  NT G
Sbjct: 991  VTGKKCDRCAHGYFNFQEGG------CTACECS-----HLGNNCDPKTGRCI-CPPNTIG 1038

Query: 859  FYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGA 918
              C +C    +G+ +       CKACNC+  G++  Q  CN  TGQC C P  +G  C  
Sbjct: 1039 EKCSKCAPNTWGHSITTG----CKACNCSTVGSLDFQ--CNVNTGQCNCHPKFSGAKCTE 1092

Query: 919  CDPGFYNLQSGQGCERCDCHALGSTNGQCDI---------RTGQCECQPGITGQHCERCE 969
            C  G +N      C  CDC   G+    CD          +TGQC C+  + G HC+RC 
Sbjct: 1093 CSRGHWNYPR---CNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCR 1149

Query: 970  VNHFGF---GPEGCKPCDC 985
               FG     P GC  C C
Sbjct: 1150 PGKFGLDAKNPLGCSSCYC 1168



 Score =  149 bits (377), Expect = 2e-35
 Identities = 197/870 (22%), Positives = 350/870 (40%), Gaps = 151/870 (17%)

Query: 778  GSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYF---GDPLGRN-GP-VRLCRLCQCSD 832
            G    + P    +   +CP G +G  CE C  G++     P GR  GP +  C  CQC+ 
Sbjct: 1365 GRGTTMTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNG 1424

Query: 833  NIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTM 892
            +        C+  T  C  C ++TAG +C+RC  G++G  +     + C+ C C L  + 
Sbjct: 1425 HSSL-----CDPETSICQNCQHHTAGDFCERCALGYYG--IVKGLPNDCQQCACPLISSS 1477

Query: 893  KQQSSCNPVTG----QCECLPH-VTGQDCGACDPGFYNLQSGQG--CERCDCHALGSTNG 945
               S      G    +C   P    GQ C  C PG+       G  C+ C+C   GS   
Sbjct: 1478 NNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPV 1537

Query: 946  QCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGRCECRE 1005
             CD  TG C C+PG TG+ C+ C+  H               EG   + C D    EC  
Sbjct: 1538 PCDPVTGFCTCRPGATGRKCDGCKHWH-------------AREGWECVFCGD----ECTG 1580

Query: 1006 GFVGNRCDQCEENYFYNRSWPGCQECPACYRLV---------------KDKVADHRVKLQ 1050
              +G+     +     N + P     PA Y+++                 +  +  ++L 
Sbjct: 1581 LLLGDLARLEQMVMSINLTGP----LPAPYKMLYGLENMTQELKHLLSPQRAPERLIQLA 1636

Query: 1051 E--LESLIANLG---------TGDEMVTDQAFE---DRLKEAEREVMDLLREAQDVKDVD 1096
            E  L +L+  +          T D   T Q  E    R K     + +L R+A+ V    
Sbjct: 1637 EGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVN--- 1693

Query: 1097 QNLMDRLQRVNNTLSSQISRLQ-NIRNTIEETGNLAEQARAHVENTERLIEIASRELEKA 1155
                ++  ++N TL ++    + N+    +E   + ++ R   +N E   EIA  EL  A
Sbjct: 1694 ----EKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRR--KNLETQKEIAEDELVAA 1747

Query: 1156 KVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLL 1215
            +     V     ES G+   M    ++ R+    +K + DD   + + A D   EA  L 
Sbjct: 1748 EALLKKVKKLFGESRGENEEM---EKDLREKLADYKNKVDDAWDLLREATDKIREANRLF 1804

Query: 1216 LRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLS 1275
               +  +N TA  +E+     E  K   ++  K+   + +EA R  D             
Sbjct: 1805 --AVNQKNMTA--LEKKKEAVESGKRQIENTLKEGNDILDEANRLAD------------- 1847

Query: 1276 PLDSETLENEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQQTA 1335
                     E N+I    E+++  +    ++  D  +D+  +E++ + L EK    +  A
Sbjct: 1848 ---------EINSIIDYVEDIQTKLPPMSEELNDKIDDL-SQEIKDRKLAEKVSQAESHA 1897

Query: 1336 DQLLARADAAKALAEEAAKKGRDTLQEANDILNNLKDFDRRVNDNKTAAEEALRKIPAIN 1395
             Q                      L +++ +L+ + D  + ++ N TAA +A      I 
Sbjct: 1898 AQ----------------------LNDSSAVLDGILDEAKNISFNATAAFKAYSN---IK 1932

Query: 1396 QTITEANEKTREAQQALGSAAADATEAKNKAHEAERIASAVQKNATSTKAEAERTFAEVT 1455
              I EA +  +EA+     A   AT  +    E  +    +QK+      EA++   +V 
Sbjct: 1933 DYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAK--GCLQKSFRILN-EAKKLANDVK 1989

Query: 1456 DLDNEVNNMLKQLQEAEKE----LKRKQDDADQDMMMAGMASQAAQEAEINARKAKNSVT 1511
            + ++ +N +  +++ A+      L+   D   +   +    +   Q  +  AR+A ++  
Sbjct: 1990 ENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKDKARQANDTAK 2049

Query: 1512 SLLSIINDLLEQLGQLDTVDLNKL-NEIEGTLNKAKDEMK---VSDLDRKVSDLENEAKK 1567
             +L+ I +L + L  L   + NKL + +  T    KD  K   ++D D  V +LE EA +
Sbjct: 2050 DVLAQITELHQNLDGLKK-NYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLEQEADR 2108

Query: 1568 QEAAIMDYNRDIEEIMKDI-RNLEDIRKTL 1596
                ++D  + I+E+  ++ +N+ +I++ +
Sbjct: 2109 ----LIDKLKPIKELEDNLKKNISEIKELI 2134



 Score =  134 bits (337), Expect = 7e-31
 Identities = 73/216 (33%), Positives = 97/216 (44%), Gaps = 22/216 (10%)

Query: 286  CKCNGHASECMKNEFDKLVCNC---KHNTYGVDCEKCLP-FFNDRPWRRATAESASECLP 341
            C+CN +    +    D L  +C   K  T G  CE C   +F D       A  A  C P
Sbjct: 865  CQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGD-------AVDAKNCQP 917

Query: 342  CDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCS 401
            C CN       F    +  TG       C+ N  G  C++C+   F L +   C  C+C+
Sbjct: 918  CRCNAGGS---FSEVCHSQTGQ----CECRANVQGQRCDKCKAGTFGLQSARGCVPCNCN 970

Query: 402  PVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIETG 461
              GS S  C+  G+C C+PGV G KCDRC  G+ +  E GC  C C   G  + C+ +TG
Sbjct: 971  SFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLG--NNCDPKTG 1028

Query: 462  RCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFC 497
            RC+C  N  G  C +C P  +    S   GC  C C
Sbjct: 1029 RCICPPNTIGEKCSKCAPNTWG--HSITTGCKACNC 1062



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 74/347 (21%), Positives = 148/347 (42%), Gaps = 40/347 (11%)

Query: 1040 DKVADHRVKLQEL-ESLIANLGTGDEMVTDQAFEDRLKEAEREVMDLLREAQDVKDVDQN 1098
            D V D + KL  + E L   +    + + D+   +++ +AE     L     D   V   
Sbjct: 1854 DYVEDIQTKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQL----NDSSAVLDG 1909

Query: 1099 LMDRLQRVNNTLSSQISRLQNIRNTIEETGNLAEQAR--AHVENTERLIEIASRELEKAK 1156
            ++D  + ++   ++      NI++ I+E   +A++A+  AH               E  K
Sbjct: 1910 ILDEAKNISFNATAAFKAYSNIKDYIDEAEKVAKEAKDLAH---------------EATK 1954

Query: 1157 VAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLLL 1216
            +A     + + ++ G       +  EA+KLA   K E +D +   KT  + +      LL
Sbjct: 1955 LATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVK-ENEDHLNGLKTRIENADARNGDLL 2013

Query: 1217 RTL--------AGENQTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIY 1268
            RTL        A  N TA +++ +  K  QA + ++D+  Q   +H+          ++ 
Sbjct: 2014 RTLNDTLGKLSAIPNDTAAKLQAVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNKLA 2073

Query: 1269 ASVAQLSPLDSETLENEA-NNIKMEAENLEQLIDQ---KLKDYEDLREDMRGKELEVKNL 1324
             SVA+ + +  +  +N+   +     +NLEQ  D+   KLK  ++L ++++    E+K L
Sbjct: 2074 DSVAKTNAVVKDPSKNKIIADADATVKNLEQEADRLIDKLKPIKELEDNLKKNISEIKEL 2133

Query: 1325 LEKGKTEQQTADQLLARADAAKALAEEAAKKGRDTLQEANDILNNLK 1371
            + + + +  +    ++         +   KKG       N+I+ N+K
Sbjct: 2134 INQARKQANSIKVSVSSGGDCIRTYKPEIKKG-----SYNNIVVNVK 2175



 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 30/99 (30%), Positives = 41/99 (41%), Gaps = 11/99 (11%)

Query: 943  TNGQCDIRTGQCECQPGITGQHCERC-----EVNHFGFGPEGCKPCDCHPEGSLSLQCKD 997
            T+G        C+C PG TG  CE C      VN   FG   C+PC C         C D
Sbjct: 713  TDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGI-CEPCQCFGHAE---SCDD 768

Query: 998  -DGRC-ECREGFVGNRCDQCEENYFYNRSWPGCQECPAC 1034
              G C  C++   G  CD+C   ++   +    ++C  C
Sbjct: 769  VTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPC 807



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 51/229 (22%), Positives = 97/229 (42%), Gaps = 30/229 (13%)

Query: 1391 IPAINQTITEANEKTREAQQALGSAAADATEAKNKAH---EAERIASAVQKNA---TSTK 1444
            +  +N+ +T A + T + +Q    A    T AK+      E  R A AV + A     T 
Sbjct: 1644 VTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLNETL 1703

Query: 1445 AEAERTFAE-VTDLDNEVNNMLKQLQEAEKELKRKQDDADQDMMMA-----------GMA 1492
               +  F   +  L  E++ M+K+L+   K L+ +++ A+ +++ A           G +
Sbjct: 1704 GTRDEAFERNLEGLQKEIDQMIKELRR--KNLETQKEIAEDELVAAEALLKKVKKLFGES 1761

Query: 1493 SQAAQEAEINARKA----KNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDE 1548
                +E E + R+     KN V     ++ +  +++ +      N+L  +    N    E
Sbjct: 1762 RGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREA-----NRLFAVNQK-NMTALE 1815

Query: 1549 MKVSDLDRKVSDLENEAKKQEAAIMDYNRDIEEIMKDIRNLEDIRKTLP 1597
             K   ++     +EN  K+    + + NR  +EI   I  +EDI+  LP
Sbjct: 1816 KKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLP 1864


>gi|148613884 netrin 1 [Homo sapiens]
          Length = 604

 Score =  443 bits (1140), Expect = e-124
 Identities = 219/453 (48%), Positives = 298/453 (65%), Gaps = 30/453 (6%)

Query: 17  LWPVLAVLAAAAAAGCA------------QAAM-DECTDEGGRPQRCMPEFVNAAFNVTV 63
           +W  LA LAA A    A            QAA  D C+DE G P+RC+P+FVNAAF   V
Sbjct: 5   VWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDV 64

Query: 64  VATNTCGTPPEEYCV--QTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQSQ 121
             ++TCG PP  YCV  + G   + +SCHLC+A  P   H  AFLTD NN  + T WQS+
Sbjct: 65  RVSSTCGRPPARYCVVSERGEERL-RSCHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSE 123

Query: 122 TMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGS 181
             L   Q+P ++ LTL LGK F++TYV L+F + RPES AIYK       W+P+Q+YS  
Sbjct: 124 NYL---QFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQ 180

Query: 182 CENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQ 241
           C   Y++ +R  I T  +EQ+A+CTD  +D+ PL+GG +AFSTL+GRPSA++FDNSPVLQ
Sbjct: 181 CRKMYNRPHRAPI-TKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQ 239

Query: 242 EWVTATDIRVTLNRLNTFGDEVFNDPKVLK-SYYYAISDFAVGGRCKCNGHASECMKNEF 300
           +WVTATDIRV  +RL+TFGDE  +D ++ + SY+YA+SD  VGGRCKCNGHA+ C+++  
Sbjct: 240 DWVTATDIRVAFSRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHAARCVRDRD 299

Query: 301 DKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRS 360
           D LVC+C+HNT G +C++C PF  DRPW+RATA  A+EC+ C+CN  ++ C F+ ELY+ 
Sbjct: 300 DSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKL 359

Query: 361 TGH--GGHCTNCQDNTDGAHCERCRENFFR-----LGNNEACSSCHCSPVGSLSTQCD-S 412
           +G   GG C NC+ NT G HC  C+E ++R     + + +AC +C C PVG+    C+ +
Sbjct: 360 SGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKTCNQT 419

Query: 413 YGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPC 445
            G+C CK GV G  C+RC  G+   + +   PC
Sbjct: 420 TGQCPCKDGVTGITCNRCAKGYQQ-SRSPIAPC 451



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 55/170 (32%), Positives = 83/170 (48%), Gaps = 22/170 (12%)

Query: 724 CACNGHSETC---DPETGVCNCRDNTAGPHCEKCSDGYYG----DSTAGTSSDCQPCPCP 776
           C CNGH+  C     ++ VC+CR NTAGP C++C   +Y      +TA  +++C  C C 
Sbjct: 285 CKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCN 344

Query: 777 -GGSSCAVVPKTKEV-------VCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLC 828
                C    +  ++       VC NC   T G+ C  C +GY+ D +G+  P+   + C
Sbjct: 345 LHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRD-MGK--PITHRKAC 401

Query: 829 QCSDNIDPNAVG-NCNRLTGECLKCIYNTAGFYCDRCKDGF--FGNPLAP 875
           +  D     A G  CN+ TG+C  C     G  C+RC  G+    +P+AP
Sbjct: 402 KACDCHPVGAAGKTCNQTTGQC-PCKDGVTGITCNRCAKGYQQSRSPIAP 450



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 49/151 (32%), Positives = 69/151 (45%), Gaps = 24/151 (15%)

Query: 842 CNRLTGECLK---------CIYNTAGFYCDRCKDGFFGNP---LAPNPADKCKACNCNLY 889
           CN     C++         C +NTAG  CDRCK   +  P        A++C ACNCNL+
Sbjct: 287 CNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLH 346

Query: 890 GTMKQ------QSSCNPVTGQC-ECLPHVTGQDCGACDPGFYN-----LQSGQGCERCDC 937
               +      + S     G C  C  +  G+ C  C  G+Y      +   + C+ CDC
Sbjct: 347 ARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDC 406

Query: 938 HALGSTNGQCDIRTGQCECQPGITGQHCERC 968
           H +G+    C+  TGQC C+ G+TG  C RC
Sbjct: 407 HPVGAAGKTCNQTTGQCPCKDGVTGITCNRC 437



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 52/168 (30%), Positives = 77/168 (45%), Gaps = 18/168 (10%)

Query: 773 CPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGP--VRLCRLCQC 830
           C C G ++  V  +   +VC +C   T G  C+ C   ++  P  R        C  C C
Sbjct: 285 CKCNGHAARCVRDRDDSLVC-DCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNC 343

Query: 831 S-------DNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFF---GNPLAPNPADK 880
           +        N++   +    +  G CL C +NTAG +C  CK+G++   G P+    A  
Sbjct: 344 NLHARRCRFNMELYKLSG-RKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKA-- 400

Query: 881 CKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQS 928
           CKAC+C+  G   +  +CN  TGQC C   VTG  C  C  G+   +S
Sbjct: 401 CKACDCHPVGAAGK--TCNQTTGQCPCKDGVTGITCNRCAKGYQQSRS 446



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 44/166 (26%), Positives = 70/166 (42%), Gaps = 29/166 (17%)

Query: 884  CNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYN-------LQSGQGCERCD 936
            C CN +     +   + +   C+C  +  G +C  C P  Y+        +    C  C+
Sbjct: 285  CKCNGHAARCVRDRDDSLV--CDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACN 342

Query: 937  C--HA--------LGSTNGQCDIRTGQC-ECQPGITGQHCERCEVNHF-GFGP-----EG 979
            C  HA        L   +G+     G C  C+    G+HC  C+  ++   G      + 
Sbjct: 343  CNLHARRCRFNMELYKLSGRKS--GGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKA 400

Query: 980  CKPCDCHPEGSLSLQCKDD-GRCECREGFVGNRCDQCEENYFYNRS 1024
            CK CDCHP G+    C    G+C C++G  G  C++C + Y  +RS
Sbjct: 401  CKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRS 446



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 47/144 (32%), Positives = 57/144 (39%), Gaps = 28/144 (19%)

Query: 690 CTCPVGYGGQFCEMCLS-----GYRRETPNLGPYSPCVLCACNGHSETCD---------- 734
           C C     G  C+ C        ++R T      + CV C CN H+  C           
Sbjct: 304 CDCRHNTAGPECDRCKPFHYDRPWQRATAREA--NECVACNCNLHARRCRFNMELYKLSG 361

Query: 735 -PETGVC-NCRDNTAGPHCEKCSDGYYGDSTAGTS--SDCQPCPC-PGGSSCAVVPKTKE 789
               GVC NCR NTAG HC  C +GYY D     +    C+ C C P G++     KT  
Sbjct: 362 RKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAA----GKTCN 417

Query: 790 VVCTNCP--TGTTGKRCELCDDGY 811
                CP   G TG  C  C  GY
Sbjct: 418 QTTGQCPCKDGVTGITCNRCAKGY 441



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 29/104 (27%), Positives = 44/104 (42%), Gaps = 23/104 (22%)

Query: 416 CSCKPGVMGDKCDRCQPGFH--------SLTEAG-CRPCSCDPSGSIDECNIET------ 460
           C C+    G +CDRC+P FH        +  EA  C  C+C+        N+E       
Sbjct: 304 CDCRHNTAGPECDRCKP-FHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGR 362

Query: 461 ---GRCV-CKDNVEGFNCERCKPGFF---NLESSNPRGCTPCFC 497
              G C+ C+ N  G +C  CK G++       ++ + C  C C
Sbjct: 363 KSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDC 406



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 37/143 (25%), Positives = 53/143 (37%), Gaps = 32/143 (22%)

Query: 918  ACDPGFY---NLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHF- 973
            A D  FY   +LQ G  C +C+ HA      + D     C+C+    G  C+RC+  H+ 
Sbjct: 268  ARDSYFYAVSDLQVGGRC-KCNGHAARCVRDRDDSLV--CDCRHNTAGPECDRCKPFHYD 324

Query: 974  -------GFGPEGCKPCDCHPEGSLSLQC------------KDDGRC-ECREGFVGNRCD 1013
                         C  C+C+       +C            K  G C  CR    G  C 
Sbjct: 325  RPWQRATAREANECVACNCNLHAR---RCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCH 381

Query: 1014 QCEENYFYNRSWP--GCQECPAC 1034
             C+E Y+ +   P    + C AC
Sbjct: 382  YCKEGYYRDMGKPITHRKACKAC 404


>gi|21264602 laminin alpha 5 [Homo sapiens]
          Length = 3695

 Score =  402 bits (1032), Expect = e-111
 Identities = 372/1343 (27%), Positives = 567/1343 (42%), Gaps = 217/1343 (16%)

Query: 305  CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHG 364
            C C  +  G DC +C   +   P           C PCDC  R  +     EL       
Sbjct: 1457 CPCHAHVIGRDCSRCATGYWGFP----------NCRPCDCGARLCD-----ELT------ 1495

Query: 365  GHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGS---LSTQCDS-YGRCSCKP 420
            G C  C   T    C  C+   F       C  C+CS  G        CD+  G+C C+P
Sbjct: 1496 GQCI-CPPRTIPPDCLLCQPQTFGCHPLVGCEECNCSGPGIQELTDPTCDTDSGQCKCRP 1554

Query: 421  GVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDE-CNIETGRCVCKDNVEGFNCERCKP 479
             V G +CD C PGFH      CRPC C  +G+    C+  TG+C CK+NV+G  C++C  
Sbjct: 1555 NVTGRRCDTCSPGFHGYPR--CRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSL 1612

Query: 480  GFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGW----------RAE 529
            G F+L+++NP+GCT CFCFG +  C ++      S +    +D +GW            E
Sbjct: 1613 GTFSLDAANPKGCTRCFCFGATERCRSS------SYTRQEFVDMEGWVLLSTDRQVVPHE 1666

Query: 530  QRDGSEASLEWSSERQDIAVISDSYFPRYFIAPAKFLGKQVLSYGQNLSFSF--RVDRRD 587
            ++ G+E  +  +  R     + +++   Y+ AP  +LG +V SYG  L +       R D
Sbjct: 1667 RQPGTE--MLRADLRHVPEAVPEAFPELYWQAPPSYLGDRVSSYGGTLRYELHSETQRGD 1724

Query: 588  TRLSAE---DLVLEGAGLRVSVPLIAQGNSYPSET------TVKYVFRLHEATDYPWRPA 638
              +  E   D+VL+G   ++S+  +      P          V+  FR  E      R  
Sbjct: 1725 VFVPMESRPDVVLQGN--QMSITFLEPAYPTPGHVHRGQLQLVEGNFRHTET-----RNT 1777

Query: 639  LTPFEFQKLLNNLTSIKIRGTYSE-RSAGYLDDVTLASARP-GPGVPATWVESCTCPVGY 696
            ++  E   +L +L  ++IR  +S+  SA +L  V L  A P G G  A+ VE C CP  Y
Sbjct: 1778 VSREELMMVLASLEQLQIRALFSQISSAVFLRRVALEVASPAGQGALASNVELCLCPASY 1837

Query: 697  GGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVC-NCRDNTAGPHCEKCS 755
             G  C+ C  G+ R+   L     CV C C+GHS+ C P +GVC +C+ NT G HCE+C 
Sbjct: 1838 RGDSCQECAPGFYRDVKGLF-LGRCVPCQCHGHSDRCLPGSGVCVDCQHNTEGAHCERCQ 1896

Query: 756  DGYYGDSTAGTSSDCQPCPCP-----GGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDG 810
             G+   S    S+ C  CPCP        +   V +     C  C  G  G  CE C  G
Sbjct: 1897 AGFV-SSRDDPSAPCVSCPCPLSVPSNNFAEGCVLRGGRTQCL-CKPGYAGASCERCAPG 1954

Query: 811  YFGDPLGRNGPVRLCRLCQCSDNIDPNAV-GNCNRLTGECLKCIYNTAGFYCDRCKDGFF 869
            +FG+PL        C+ C CS N DPN +  +C+ LTG C  C+ +T G  C+ C  GF+
Sbjct: 1955 FFGNPLVLGSS---CQPCDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRCEICAPGFY 2011

Query: 870  GNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSG 929
            GN L P     C  C+C   GT     +C+P +G C C   VTG+ C  C  G +     
Sbjct: 2012 GNALLPG---NCTRCDCTPCGT----EACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGC 2064

Query: 930  QGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEG 989
             GC  C C    +   +C  ++GQC C+PG  G  C  C   ++G   +GC+ C C P G
Sbjct: 2065 GGCRPCAC-GPAAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQGCRRCQC-PGG 2122

Query: 990  SLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPG--------CQECPACYRLVKDK 1041
                     GRC C  G  G RCD C +   +    PG        C+ C  C  L+ D 
Sbjct: 2123 RCD---PHTGRCNCPPGLSGERCDTCSQQ--HQVPVPGGPVGHSIHCEVCDHCVVLLLDD 2177

Query: 1042 V--------ADHR------------VKLQELESLIANLGT------GDEMVTDQAFEDRL 1075
            +        A H              +L  L + IA+L +      G    T Q  E   
Sbjct: 2178 LERAGALLPAIHEQLRGINASSMAWARLHRLNASIADLQSQLRSPLGPRHETAQQLEVLE 2237

Query: 1076 KEAEREVMDLLR---EAQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEE----TG 1128
            +++     D  R   +A   +D    L+   +       + ++ ++ +  T+ E    TG
Sbjct: 2238 QQSTSLGQDARRLGGQAVGTRDQASQLLAGTEATLGHAKTLLAAIRAVDRTLSELMSQTG 2297

Query: 1129 NL---------AEQARAHVENTERLI-EIASRELEKAKVAA-ANVSVTQPESTGDPNNMT 1177
            +L          EQ    +   ERL+ E+ +R+L   + AA A ++  Q         ++
Sbjct: 2298 HLGLANASAPSGEQLLRTLAEVERLLWEMRARDLGAPQAAAEAELAAAQRLLARVQEQLS 2357

Query: 1178 LLAEEARKLA-------ERHKQEADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIE 1230
             L EE + LA        +H+    D+      A D + EA  L  R     NQ   E E
Sbjct: 2358 SLWEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSR-----NQERLE-E 2411

Query: 1231 ELNRKYEQAK---------NISQDLEKQAARVHEEAKRAGDKAVEIYAS----------- 1270
             L RK E ++         + ++D      R+     +A ++   + AS           
Sbjct: 2412 ALQRKQELSRDNATLQATLHAARDTLASVFRLLHSLDQAKEELERLAASLDGARTPLLQR 2471

Query: 1271 VAQLSPLDSETLENEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKT 1330
            +   SP  S+    EA   +  A+ L QL         D+ +D          L ++   
Sbjct: 2472 MQTFSPAGSKLRLVEA--AEAHAQQLGQLALNLSSIILDVNQD---------RLTQRAIE 2520

Query: 1331 EQQTADQLLARADAAKALAEEAAKKGRDTLQEANDILNNLKDFDRRVNDNKTAAEEAL-- 1388
                  ++L    AA+  A +A ++   T   A  +   L D  +++  N TA EEA+  
Sbjct: 2521 ASNAYSRILQAVQAAEDAAGQALQQADHTW--ATVVRQGLVDRAQQLLANSTALEEAMLQ 2578

Query: 1389 --RKIPAINQTITEANEKTREAQQALGSAAADATEAKNKAHEAERIASAVQKNATSTK-A 1445
              +++  +   +  A  + R+ +     A  D  EA  +A +A     A+  + TS K A
Sbjct: 2579 EQQRLGLVWAALQGARTQLRDVR-----AKKDQLEAHIQAAQA---MLAMDTDETSKKIA 2630

Query: 1446 EAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDADQDMMMAGMASQAAQEAEINARK 1505
             A+   AE  D    V + L+ +QE    ++R Q   +      G+  Q   +A ++   
Sbjct: 2631 HAKAVAAEAQDTATRVQSQLQAMQE---NVERWQGQYE------GLRGQDLGQAVLD--- 2678

Query: 1506 AKNSVTSLLSIINDLLEQLGQLD 1528
            A +SV++L   +  LL +L  L+
Sbjct: 2679 AGHSVSTLEKTLPQLLAKLSILE 2701



 Score =  301 bits (772), Expect = 3e-81
 Identities = 184/553 (33%), Positives = 264/553 (47%), Gaps = 78/553 (14%)

Query: 7   AAPALRPRGRLWPVLAVLAAAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFNVTVVAT 66
           A  AL  RG   P   +L   A  G A+A      +E G      P + N A    + A+
Sbjct: 7   AGSALCVRGPRGPAPLLLVGLALLGAARAR-----EEAGGGFSLHPPYFNLAEGARIAAS 61

Query: 67  NTCGT---------PPEE-YCVQTG--VTGVTKS-------CHLCDAGQPHLQHGAAFLT 107
            TCG          P E+ YC   G  V G   +       C +C A   +  H A+   
Sbjct: 62  ATCGEEAPARGSPRPTEDLYCKLVGGPVAGGDPNQTIRGQYCDICTAANSNKAHPASNAI 121

Query: 108 DYNNQADTTWWQSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTR 167
           D   +    WWQS  +  G++Y + +N+TL LG+ F + YV +KF  S      + +R+ 
Sbjct: 122 DGTER----WWQSPPLSRGLEY-NEVNVTLDLGQVFHVAYVLIKFANSPRPDLWVLERSM 176

Query: 168 EDG-PWIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLE 226
           + G  + P+Q+++ S  +   +     +     +  A+CT E+S I PL  G +  S + 
Sbjct: 177 DFGRTYQPWQFFASSKRDCLERFGPQTLERITRDDAAICTTEYSRIVPLENGEIVVSLVN 236

Query: 227 GRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTF----GDEVFNDPKVLKSYYYAISDFAV 282
           GRP A NF  SP+L+E+  AT++R+   R NT       +   DP V + YYY+I D ++
Sbjct: 237 GRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLMGKALRDPTVTRRYYYSIKDISI 296

Query: 283 GGRCKCNGHASEC-MKNEFD--KLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASEC 339
           GGRC C+GHA  C  K+  D  +L C C+HNT G  C++C P FN +PW+ ATA SA+EC
Sbjct: 297 GGRCVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANEC 356

Query: 340 LPCDCNGRSQECYFDPELYRSTGH---------GGHCTNCQDNTDGAHCERCRENFFRLG 390
             C+C G + +CY+DPE+ R             GG C +CQ +T G +CERC   F+R  
Sbjct: 357 QSCNCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSP 416

Query: 391 NN-----EACSSCHCSPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPC 445
           N+       C  C+C    +  T  D  GRC C+P   G++CD C  GF         P 
Sbjct: 417 NHPLDSPHVCRRCNCESDFTDGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFPSCYPTPS 476

Query: 446 SCD-------PSGSIDECNI--------------ETGRCVCKDNVEGFNCERCKPGFFNL 484
           S +       P+G I  C+                 GRC+CK N +G +CE C PGF+  
Sbjct: 477 SSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHCELCAPGFYG- 535

Query: 485 ESSNPRGCTPCFC 497
                 GC PC C
Sbjct: 536 -----PGCQPCQC 543



 Score =  205 bits (521), Expect = 3e-52
 Identities = 114/346 (32%), Positives = 157/346 (45%), Gaps = 51/346 (14%)

Query: 724  CACNGHSETCDPETGV------CNCRDNTAGPHCEKCSDGY----YGDSTAGTSSDCQPC 773
            C C+GH++ CD +         C C+ NT G  C++C  G+    +  +TA ++++CQ C
Sbjct: 300  CVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSC 359

Query: 774  PCPG-GSSCAVVPKTKEV--------------VCTNCPTGTTGKRCELCDDGYFGDPLGR 818
             C G  + C   P+                  VC +C   TTG  CE C  G++  P   
Sbjct: 360  NCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHP 419

Query: 819  NGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFG------NP 872
                 +CR C C  +      G C  LTG C  C  N +G  CD C +GF G       P
Sbjct: 420  LDSPHVCRRCNCESDFTD---GTCEDLTGRCY-CRPNFSGERCDVCAEGFTGFPSCYPTP 475

Query: 873  LAPN-------PADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYN 925
             + N       PA +   C+C+  GT       +P  G+C C P+  G  C  C PGFY 
Sbjct: 476  SSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHCELCAPGFY- 534

Query: 926  LQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDC 985
               G GC+ C C + G  + +CD  TGQC C+ G  G  C+RC   +F F    C+ C C
Sbjct: 535  ---GPGCQPCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHF--PLCQLCGC 589

Query: 986  HPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQEC 1031
             P G+L   C + GRC C+  F G  CD+C   Y     +P CQ C
Sbjct: 590  SPAGTLPEGCDEAGRCLCQPEFAGPHCDRCRPGY---HGFPNCQAC 632



 Score =  179 bits (454), Expect = 2e-44
 Identities = 122/380 (32%), Positives = 161/380 (42%), Gaps = 62/380 (16%)

Query: 690  CTCPVGYGGQFCEMCLSGYRR-----ETPNLG--------PYSPCVLCACN-----GHSE 731
            C C   + G+ C++C  G+        TP+          P    V C C+     G++ 
Sbjct: 447  CYCRPNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNAC 506

Query: 732  TCDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPC--PGGSSCAVVPKTKE 789
              DP  G C C+ N  G HCE C+ G+YG         CQPC C  PG +     P T +
Sbjct: 507  RKDPRVGRCLCKPNFQGTHCELCAPGFYGPG-------CQPCQCSSPGVADDRCDPDTGQ 559

Query: 790  VVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGEC 849
                 C  G  G  C+ C  GYF  PL        C+LC CS          C+   G C
Sbjct: 560  C---RCRVGFEGATCDRCAPGYFHFPL--------CQLCGCSPA--GTLPEGCDE-AGRC 605

Query: 850  LKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLP 909
            L C    AG +CDRC+ G+ G P        C+AC C+  G + Q        G C C P
Sbjct: 606  L-CQPEFAGPHCDRCRPGYHGFP-------NCQACTCDPRGALDQLCGAG---GLCRCRP 654

Query: 910  HVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCE 969
              TG  C  C PGF+   S   C  C C A GS +  CD R+GQC C+P +TG  C+ C 
Sbjct: 655  GYTGTACQECSPGFHGFPS---CVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCV 711

Query: 970  VNHFGFGPEGCKPCDCHPEGSLSLQ---CKDDGRCECREGFVGNRCDQCEENYF-YNRSW 1025
               + F    C+   CHP G   +     +    C CR    G  CD+C+  ++  + S 
Sbjct: 712  PGAYNF--PYCEAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSCDRCKPGFWGLSPSN 769

Query: 1026 P-GCQECPACYRLVKDKVAD 1044
            P GC  C    R     VA+
Sbjct: 770  PEGCTRCSCDLRGTLGGVAE 789



 Score =  168 bits (425), Expect = 4e-41
 Identities = 110/389 (28%), Positives = 154/389 (39%), Gaps = 80/389 (20%)

Query: 690  CTCPVGYGGQFCEMCLSGYRRETPNLGPYSP--------CVLCACNGHSETC--DPET-- 737
            CTC     G  C+ C  G+ ++     P+ P        C  C C GH+  C  DPE   
Sbjct: 322  CTCQHNTCGGTCDRCCPGFNQQ-----PWKPATANSANECQSCNCYGHATDCYYDPEVDR 376

Query: 738  --------------GVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSSD--CQPCPCPGGSS 780
                          GVC +C+ +T G +CE+C  G+Y        S   C+ C C    +
Sbjct: 377  RRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFT 436

Query: 781  CAVVPKTKEVVCTN------CPTGTTGKRCELCDDGYFG------DPLGRNG------PV 822
                    +  C +      C    +G+RC++C +G+ G       P   N       P 
Sbjct: 437  --------DGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPA 488

Query: 823  RLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCK 882
                 C CS           +   G CL C  N  G +C+ C  GF+G          C+
Sbjct: 489  GQIVNCDCSAAGTQGNACRKDPRVGRCL-CKPNFQGTHCELCAPGFYG--------PGCQ 539

Query: 883  ACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGS 942
             C C+  G    +  C+P TGQC C     G  C  C PG+++      C+ C C   G+
Sbjct: 540  PCQCSSPGVADDR--CDPDTGQCRCRVGFEGATCDRCAPGYFHFPL---CQLCGCSPAGT 594

Query: 943  TNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGRCE 1002
                CD   G+C CQP   G HC+RC   + GF    C+ C C P G+L   C   G C 
Sbjct: 595  LPEGCD-EAGRCLCQPEFAGPHCDRCRPGYHGF--PNCQACTCDPRGALDQLCGAGGLCR 651

Query: 1003 CREGFVGNRCDQCEENYFYNRSWPGCQEC 1031
            CR G+ G  C +C   +     +P C  C
Sbjct: 652  CRPGYTGTACQECSPGF---HGFPSCVPC 677



 Score =  167 bits (424), Expect = 6e-41
 Identities = 108/343 (31%), Positives = 145/343 (42%), Gaps = 47/343 (13%)

Query: 690  CTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHS---ETCDPETGVCNCRDNT 746
            C C VG+ G  C+ C  GY         +  C LC C+      E CD E G C C+   
Sbjct: 560  CRCRVGFEGATCDRCAPGYFH-------FPLCQLCGCSPAGTLPEGCD-EAGRCLCQPEF 611

Query: 747  AGPHCEKCSDGYYGDSTAGTSSDCQPCPC-PGGSSCAVVPKTKEVVCTNCPTGTTGKRCE 805
            AGPHC++C  GY+G        +CQ C C P G+   +       +C  C  G TG  C+
Sbjct: 612  AGPHCDRCRPGYHG------FPNCQACTCDPRGALDQLCGAGG--LC-RCRPGYTGTACQ 662

Query: 806  LCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCK 865
             C  G+ G P         C  C CS     +A   C+  +G+C  C     G  CD C 
Sbjct: 663  ECSPGFHGFPS--------CVPCHCSAEGSLHAA--CDPRSGQC-SCRPRVTGLRCDTCV 711

Query: 866  DGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYN 925
             G +  P        C+A +C+  G      +       C C  HV G  C  C PGF+ 
Sbjct: 712  PGAYNFPY-------CEAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSCDRCKPGFWG 764

Query: 926  LQSG--QGCERCDCHALGSTNG--QCDIRTGQCECQPGITGQHCERCEVNHFGFGPE--- 978
            L     +GC RC C   G+  G  +C   TGQC C+P + GQ C  C+   FG       
Sbjct: 765  LSPSNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACASCKDGFFGLDQADYF 824

Query: 979  GCKPCDCHPEGSLSLQCKD-DGRCECREGFVGNRCDQCEENYF 1020
            GC+ C C   G+L   C+   G C CR    G  C +   +++
Sbjct: 825  GCRSCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 867



 Score =  153 bits (387), Expect = 1e-36
 Identities = 112/376 (29%), Positives = 148/376 (39%), Gaps = 109/376 (28%)

Query: 687 VESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSP-CVLCACNG---HSETCDPETGVCNC 742
           V  C C   + G  CE+C  G+         Y P C  C C+      + CDP+TG C C
Sbjct: 512 VGRCLCKPNFQGTHCELCAPGF---------YGPGCQPCQCSSPGVADDRCDPDTGQCRC 562

Query: 743 RDNTAGPHCEKCSDGYY--------GDSTAGTSSD---------CQP------CP----- 774
           R    G  C++C+ GY+        G S AGT  +         CQP      C      
Sbjct: 563 RVGFEGATCDRCAPGYFHFPLCQLCGCSPAGTLPEGCDEAGRCLCQPEFAGPHCDRCRPG 622

Query: 775 ---CPGGSSCAVVPK-TKEVVC-----TNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLC 825
               P   +C   P+   + +C       C  G TG  C+ C  G+ G P         C
Sbjct: 623 YHGFPNCQACTCDPRGALDQLCGAGGLCRCRPGYTGTACQECSPGFHGFP--------SC 674

Query: 826 RLCQCSDN------IDPNAVGNCN---RLTG-ECLKCI---YN----------------- 855
             C CS         DP + G C+   R+TG  C  C+   YN                 
Sbjct: 675 VPCHCSAEGSLHAACDPRS-GQCSCRPRVTGLRCDTCVPGAYNFPYCEAGSCHPAGLAPV 733

Query: 856 ----------------TAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCN 899
                             G  CDRCK GF+G  L+P+  + C  C+C+L GT+   + C 
Sbjct: 734 DPALPEAQVPCMCRAHVEGPSCDRCKPGFWG--LSPSNPEGCTRCSCDLRGTLGGVAECQ 791

Query: 900 PVTGQCECLPHVTGQDCGACDPGFYNLQSGQ--GCERCDCHALGSTNGQCDIRTGQCECQ 957
           P TGQC C PHV GQ C +C  GF+ L      GC  C C   G+    C+ RTG C C+
Sbjct: 792 PGTGQCFCKPHVCGQACASCKDGFFGLDQADYFGCRSCRCDIGGALGQSCEPRTGVCRCR 851

Query: 958 PGITGQHCERCEVNHF 973
           P   G  C     +H+
Sbjct: 852 PNTQGPTCSEPARDHY 867



 Score =  131 bits (330), Expect = 5e-30
 Identities = 74/223 (33%), Positives = 95/223 (42%), Gaps = 36/223 (16%)

Query: 286 CKCNGHASECMKNEFDKLV--CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCD 343
           C C+   ++      D  V  C CK N  G  CE C P F               C PC 
Sbjct: 494 CDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHCELCAPGFY-----------GPGCQPCQ 542

Query: 344 CNG---RSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHC 400
           C+        C  DP+        G C  C+   +GA C+RC   +F       C  C C
Sbjct: 543 CSSPGVADDRC--DPDT-------GQC-RCRVGFEGATCDRCAPGYFHF---PLCQLCGC 589

Query: 401 SPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIET 460
           SP G+L   CD  GRC C+P   G  CDRC+PG+H      C+ C+CDP G++D+     
Sbjct: 590 SPAGTLPEGCDEAGRCLCQPEFAGPHCDRCRPGYHGF--PNCQACTCDPRGALDQLCGAG 647

Query: 461 GRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSV 503
           G C C+    G  C+ C PGF    S     C PC C    S+
Sbjct: 648 GLCRCRPGYTGTACQECSPGFHGFPS-----CVPCHCSAEGSL 685



 Score =  126 bits (316), Expect = 2e-28
 Identities = 86/289 (29%), Positives = 116/289 (40%), Gaps = 77/289 (26%)

Query: 286  CKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFF---NDRP--------------- 327
            C+C+GH+  C+      +  +C+HNT G  CE+C   F    D P               
Sbjct: 1864 CQCHGHSDRCLPG--SGVCVDCQHNTEGAHCERCQAGFVSSRDDPSAPCVSCPCPLSVPS 1921

Query: 328  ---------------------WRRATAESAS------------ECLPCDCNGRSQECYFD 354
                                 +  A+ E  +             C PCDC+G       D
Sbjct: 1922 NNFAEGCVLRGGRTQCLCKPGYAGASCERCAPGFFGNPLVLGSSCQPCDCSGNG-----D 1976

Query: 355  PELYRSTGH--GGHCTNCQDNTDGAHCERCRENFFRLGN---NEACSSCHCSPVGSLSTQ 409
            P L  S      G C  C  +T G  CE C   F+  GN      C+ C C+P G  +  
Sbjct: 1977 PNLLFSDCDPLTGACRGCLRHTTGPRCEICAPGFY--GNALLPGNCTRCDCTPCG--TEA 2032

Query: 410  CDSY-GRCSCKPGVMGDKCDRCQPGFHSLTE-AGCRPCSCDPSGSIDECNIETGRCVCKD 467
            CD + G C CK GV G +CDRCQ G        GCRPC+C P+    EC+ ++G+C C+ 
Sbjct: 2033 CDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCGGCRPCACGPAAEGSECHPQSGQCHCRP 2092

Query: 468  NVEGFNCERCKPGFFNLESSNPRGCTPCFCFG-----HSSVCTNAVGYS 511
               G  C  C PG++ L     +GC  C C G     H+  C    G S
Sbjct: 2093 GTMGPQCRECAPGYWGLPE---QGCRRCQCPGGRCDPHTGRCNCPPGLS 2138



 Score =  124 bits (311), Expect = 7e-28
 Identities = 80/247 (32%), Positives = 109/247 (44%), Gaps = 44/247 (17%)

Query: 286 CKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLP--CD 343
           C+C+       + + D   C C+    G  C++C P +   P  +    S +  LP  CD
Sbjct: 541 CQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGCSPAGTLPEGCD 600

Query: 344 CNGRS------------------------QECYFDPE--LYRSTGHGGHCTNCQDNTDGA 377
             GR                         Q C  DP   L +  G GG C  C+    G 
Sbjct: 601 EAGRCLCQPEFAGPHCDRCRPGYHGFPNCQACTCDPRGALDQLCGAGGLC-RCRPGYTGT 659

Query: 378 HCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSY-GRCSCKPGVMGDKCDRCQPGFHS 436
            C+ C   F       +C  CHCS  GSL   CD   G+CSC+P V G +CD C PG ++
Sbjct: 660 ACQECSPGFHGF---PSCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYN 716

Query: 437 LTEAGCRPCSCDPSG------SIDECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPR 490
                C   SC P+G      ++ E  +    C+C+ +VEG +C+RCKPGF+ L  SNP 
Sbjct: 717 FPY--CEAGSCHPAGLAPVDPALPEAQVP---CMCRAHVEGPSCDRCKPGFWGLSPSNPE 771

Query: 491 GCTPCFC 497
           GCT C C
Sbjct: 772 GCTRCSC 778



 Score =  122 bits (306), Expect = 3e-27
 Identities = 72/210 (34%), Positives = 96/210 (45%), Gaps = 30/210 (14%)

Query: 304  VCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGH 363
            +C C  +  G  C++C P F    +R         C+PC C+G S  C            
Sbjct: 1830 LCLCPASYRGDSCQECAPGF----YRDVKGLFLGRCVPCQCHGHSDRC---------LPG 1876

Query: 364  GGHCTNCQDNTDGAHCERCRENFF--RLGNNEACSSCHCS---PVGSLSTQCDSYG---R 415
             G C +CQ NT+GAHCERC+  F   R   +  C SC C    P  + +  C   G   +
Sbjct: 1877 SGVCVDCQHNTEGAHCERCQAGFVSSRDDPSAPCVSCPCPLSVPSNNFAEGCVLRGGRTQ 1936

Query: 416  CSCKPGVMGDKCDRCQPGFHS---LTEAGCRPCSC----DPSGSIDECNIETGRC-VCKD 467
            C CKPG  G  C+RC PGF     +  + C+PC C    DP+    +C+  TG C  C  
Sbjct: 1937 CLCKPGYAGASCERCAPGFFGNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRGCLR 1996

Query: 468  NVEGFNCERCKPGFFNLESSNPRGCTPCFC 497
            +  G  CE C PGF+   +  P  CT C C
Sbjct: 1997 HTTGPRCEICAPGFYG-NALLPGNCTRCDC 2025



 Score =  113 bits (283), Expect = 1e-24
 Identities = 66/196 (33%), Positives = 83/196 (42%), Gaps = 23/196 (11%)

Query: 286  CKCNGHAS-ECMKNEFDKLVCNCK---HNTYGVDCEKCLPFFNDRPWRRATAESASECLP 341
            C C+G+     + ++ D L   C+    +T G  CE C P F         A     C  
Sbjct: 1969 CDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRCEICAPGFY------GNALLPGNCTR 2022

Query: 342  CDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCS 401
            CDC     E   DP       H GHC  C+    G  C+RC+E  F       C  C C 
Sbjct: 2023 CDCTPCGTEAC-DP-------HSGHCL-CKAGVTGRRCDRCQEGHFGFDGCGGCRPCACG 2073

Query: 402  PVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIETG 461
            P    S      G+C C+PG MG +C  C PG+  L E GCR C C P G    C+  TG
Sbjct: 2074 PAAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQGCRRCQC-PGG---RCDPHTG 2129

Query: 462  RCVCKDNVEGFNCERC 477
            RC C   + G  C+ C
Sbjct: 2130 RCNCPPGLSGERCDTC 2145



 Score =  112 bits (280), Expect = 3e-24
 Identities = 72/221 (32%), Positives = 97/221 (43%), Gaps = 30/221 (13%)

Query: 720  PCVLCACNGHSETCDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGS 779
            PC          TC+P  G C C  +  G  C +C+ GY+G        +C+PC C G  
Sbjct: 1437 PCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWG------FPNCRPCDC-GAR 1489

Query: 780  SCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCS-DNIDPNA 838
             C  +  T + +   CP  T    C LC    FG       P+  C  C CS   I    
Sbjct: 1490 LCDEL--TGQCI---CPPRTIPPDCLLCQPQTFG-----CHPLVGCEECNCSGPGIQELT 1539

Query: 839  VGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSC 898
               C+  +G+C KC  N  G  CD C  GF G P       +C+ C+C+  GT      C
Sbjct: 1540 DPTCDTDSGQC-KCRPNVTGRRCDTCSPGFHGYP-------RCRPCDCHEAGT--APGVC 1589

Query: 899  NPVTGQCECLPHVTGQDCGACDPGFYNLQSG--QGCERCDC 937
            +P+TGQC C  +V G  C  C  G ++L +   +GC RC C
Sbjct: 1590 DPLTGQCYCKENVQGPKCDQCSLGTFSLDAANPKGCTRCFC 1630



 Score =  109 bits (273), Expect = 2e-23
 Identities = 65/202 (32%), Positives = 92/202 (45%), Gaps = 27/202 (13%)

Query: 304 VCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGR-SQECYFDPELYRSTG 362
           +C C+    G  C++C P F+  P           C+PC C+   S     DP       
Sbjct: 649 LCRCRPGYTGTACQECSPGFHGFP----------SCVPCHCSAEGSLHAACDPR------ 692

Query: 363 HGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQC-DSYGRCSCKPG 421
             G C+ C+    G  C+ C    +     EA  SCH + +  +     ++   C C+  
Sbjct: 693 -SGQCS-CRPRVTGLRCDTCVPGAYNFPYCEA-GSCHPAGLAPVDPALPEAQVPCMCRAH 749

Query: 422 VMGDKCDRCQPGFHSLTEA---GCRPCSCDPSGSID---ECNIETGRCVCKDNVEGFNCE 475
           V G  CDRC+PGF  L+ +   GC  CSCD  G++    EC   TG+C CK +V G  C 
Sbjct: 750 VEGPSCDRCKPGFWGLSPSNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACA 809

Query: 476 RCKPGFFNLESSNPRGCTPCFC 497
            CK GFF L+ ++  GC  C C
Sbjct: 810 SCKDGFFGLDQADYFGCRSCRC 831



 Score =  100 bits (248), Expect = 1e-20
 Identities = 59/197 (29%), Positives = 82/197 (41%), Gaps = 51/197 (25%)

Query: 882  KACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQ-------------- 927
            + C C+  G      +C P  GQC C  HV G+DC  C  G++                 
Sbjct: 1436 RPCGCHEVGATGP--TCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDCGARLCDE 1493

Query: 928  -SGQ--------------------------GCERCDCHALG---STNGQCDIRTGQCECQ 957
             +GQ                          GCE C+C   G    T+  CD  +GQC+C+
Sbjct: 1494 LTGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEECNCSGPGIQELTDPTCDTDSGQCKCR 1553

Query: 958  PGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKD-DGRCECREGFVGNRCDQCE 1016
            P +TG+ C+ C     G+    C+PCDCH  G+    C    G+C C+E   G +CDQC 
Sbjct: 1554 PNVTGRRCDTCSPGFHGY--PRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCS 1611

Query: 1017 ENYF-YNRSWP-GCQEC 1031
               F  + + P GC  C
Sbjct: 1612 LGTFSLDAANPKGCTRC 1628



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 36/109 (33%), Positives = 49/109 (44%), Gaps = 10/109 (9%)

Query: 923  FYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKP 982
            FYN     G   C CH +G+T   C+   GQC C   + G+ C RC   ++GF    C+P
Sbjct: 1430 FYN----NGARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGF--PNCRP 1483

Query: 983  CDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQEC 1031
            CDC       L  +  G+C C    +   C  C+   F      GC+EC
Sbjct: 1484 CDC----GARLCDELTGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEEC 1528



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 22/81 (27%), Positives = 33/81 (40%), Gaps = 4/81 (4%)

Query: 958  PGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKD-DGRCECREGFVGNRCDQCE 1016
            P  +   C     +   F   G +PC CH  G+    C+   G+C C    +G  C +C 
Sbjct: 1413 PSSSSLFCRNAAASLSLFYNNGARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCA 1472

Query: 1017 ENYFYNRSWPGCQECPACYRL 1037
              Y+    +P C+ C    RL
Sbjct: 1473 TGYW---GFPNCRPCDCGARL 1490



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 20/58 (34%), Positives = 27/58 (46%), Gaps = 6/58 (10%)

Query: 441  GCRPCSCDPSGSIDE-CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFC 497
            G RPC C   G+    C    G+C C  +V G +C RC  G++   +     C PC C
Sbjct: 1434 GARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPN-----CRPCDC 1486



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 8/64 (12%)

Query: 446 SCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPGFFN-----LESSNPRGCTPCFCFGH 500
           +CD     D   ++   C C+ N  G  C+RC PGF         +++   C  C C+GH
Sbjct: 308 ACDAKDPTDPFRLQ---CTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSCNCYGH 364

Query: 501 SSVC 504
           ++ C
Sbjct: 365 ATDC 368


>gi|167614504 laminin, beta 1 precursor [Homo sapiens]
          Length = 1786

 Score =  340 bits (872), Expect = 7e-93
 Identities = 255/987 (25%), Positives = 433/987 (43%), Gaps = 144/987 (14%)

Query: 690  CTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVC-NCRDNTAG 748
            C C  G   + C+ CL G+         +  C  C CNGH++ CDP TG C NC+D T G
Sbjct: 840  CHCFQGVYARQCDRCLPGH-------WGFPSCQPCQCNGHADDCDPVTGECLNCQDYTMG 892

Query: 749  PHCEKCSDGYYGDSTAGTSSDCQPCPCPGGS--------SCAVVPKTKEVVCTNCPTGTT 800
             +CE+C  GYYGD   G+   C+PCPCP G         SC   P T ++ C  C  G  
Sbjct: 893  HNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQLACV-CDPGYI 951

Query: 801  GKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFY 860
            G RC+ C  GYFG+P    G    C+ CQC +NID      C++ TG CLKC+Y+T G +
Sbjct: 952  GSRCDDCASGYFGNPSEVGGS---CQPCQCHNNIDTTDPEACDKETGRCLKCLYHTEGEH 1008

Query: 861  CDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSS-----CNPVTGQCECLPHVTGQD 915
            C  C+ G++G+ L  +    C+ C CN  GT+++  +     C+  TGQC CLP+V GQ+
Sbjct: 1009 CQFCRFGYYGDALQQD----CRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQN 1064

Query: 916  CGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGF 975
            C  C P  + L SG GC+ C+C+A  S    C+  TGQC+C PG  G+ C  C+   +G 
Sbjct: 1065 CDRCAPNTWQLASGTGCDPCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCSECQELFWGD 1124

Query: 976  GPEGCKPCDCHPEGSLSLQC-KDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPAC 1034
                C+ CDC P G  + QC +  G+C C EG  G RCD+C     Y+  +P C  C  C
Sbjct: 1125 PDVECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDKCTRG--YSGVFPDCTPCHQC 1182

Query: 1035 YRLVKDKVAD-----HRVKLQELESLIANLGTGDEMVTDQAFEDRLKEAE---------- 1079
            + L    +A+     HR  L++ ++L  +   G    T  + E ++ E +          
Sbjct: 1183 FALWDVIIAELTNRTHRF-LEKAKALKISGVIGPYRETVDSVERKVSEIKDILAQSPAAE 1241

Query: 1080 --REVMDLLREAQD-VKDVDQ-------NLMDRLQRVNNT---LSSQISRLQNIRNTIEE 1126
              + + +L  EA+  +KDV +        L D   + N+T   L S  +  +++ NT++E
Sbjct: 1242 PLKNIGNLFEEAEKLIKDVTEMMAQVEVKLSDTTSQSNSTAKELDSLQTEAESLDNTVKE 1301

Query: 1127 TGNLAE-----QARAHVENTERLIEIASRELEKAKVAAANVSVTQPESTGDPNNM----- 1176
                 E       R  +++  +  +++    E+      N S T+P ST + + +     
Sbjct: 1302 LAEQLEFIKNSDIRGALDSITKYFQMSLEAEER-----VNASTTEPNSTVEQSALMRDRV 1356

Query: 1177 -TLLAEEARKLAERHKQEA---DDIVRVAKT----------------ANDTSTEAYNLLL 1216
              ++ E   +  E+ +++A   D++    ++                A+ + TE      
Sbjct: 1357 EDVMMERESQFKEKQEEQARLLDELAGKLQSLDLSAAAEMTCGTPPGASCSETECGGPNC 1416

Query: 1217 RTLAGENQTAFE-----IEELNRKYEQAKNISQDLEKQAARVHE------EAKRAGDKAV 1265
            RT  GE +         +   +  +++A ++ QD+    A V +      EAK   D+A 
Sbjct: 1417 RTDEGERKCGGPGCGGLVTVAHNAWQKAMDLDQDVLSALAEVEQLSKMVSEAKLRADEAK 1476

Query: 1266 EIYASVAQLSPLDSETLENEANNIKMEAENLEQLIDQKLKDY--------EDLREDMRGK 1317
            +    +   +    E ++     ++   + +   + Q   D         E L+ +M   
Sbjct: 1477 QSAEDILLKTNATKEKMDKSNEELRNLIKQIRNFLTQDSADLDSIEAVANEVLKMEMPST 1536

Query: 1318 ELEVKNLLE--KGKTEQQTADQLLARADAAKALAEEAAKKGRDTLQEANDILNNLKDFDR 1375
              +++NL E  + + E  +  +++ +  AA     E        L+EA     +  D   
Sbjct: 1537 PQQLQNLTEDIRERVESLSQVEVILQHSAADIARAEM------LLEEAKRASKSATDVKV 1590

Query: 1376 RVNDNKTAAEEALRKIPAINQTITEANEKTREAQQALGSAAADATEAKNKAHEAERIASA 1435
              +  K A EEA +   A  + I +A+E  +  Q  L S  ++   ++     A +  S 
Sbjct: 1591 TADMVKEALEEAEKAQVAAEKAIKQADEDIQGTQNLLTSIESETAASEETLFNASQRISE 1650

Query: 1436 VQKNATSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDADQDM-MMAGMASQ 1494
            +++N    K +A +   E   ++  V  + +  ++ +K L  + D+  + +  +    ++
Sbjct: 1651 LERNVEELKRKAAQNSGEAEYIEKVVYTVKQSAEDVKKTLDGELDEKYKKVENLIAKKTE 1710

Query: 1495 AAQEAEINARKAKNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDEMKVSDL 1554
             + +A   A   +N   +LL+  N  L+ L  L                    E K  D 
Sbjct: 1711 ESADARRKAEMLQNEAKTLLAQANSKLQLLKDL--------------------ERKYEDN 1750

Query: 1555 DRKVSDLENEAKKQEAAIMDYNRDIEE 1581
             R + D   E  + E  +    +DI +
Sbjct: 1751 QRYLEDKAQELARLEGEVRSLLKDISQ 1777



 Score =  271 bits (693), Expect = 4e-72
 Identities = 159/476 (33%), Positives = 249/476 (52%), Gaps = 60/476 (12%)

Query: 66  TNTCGT-PPEEYCVQTGVTGVTKSCHLCDAGQP---------HLQHGAAFLTDYNNQADT 115
           T+TCG   PE YC+ + +    K C +C++  P         HL      +T +      
Sbjct: 53  TSTCGLHKPEPYCIVSHLQE-DKKCFICNSQDPYHETLNPDSHLIENV--VTTFAPNRLK 109

Query: 116 TWWQSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPY 175
            WWQS+    GV+   ++ + L L   F  T++ + F T RP +  I + +     W  Y
Sbjct: 110 IWWQSEN---GVE---NVTIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTWGVY 163

Query: 176 QYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFD 235
           +Y++  CE ++   + G ++   D    +C   +SDI P T G V F  L+    A+  +
Sbjct: 164 RYFAYDCEASFPGISTGPMKKVDD---IICDSRYSDIEPSTEGEVIFRALD---PAFKIE 217

Query: 236 N--SPVLQEWVTATDIRVTLNRLNTFGDEVFNDP-KVLKSYYYAISDFAVGGRCKCNGHA 292
           +  SP +Q  +  T++R+   +L+T GD + +   ++ + YYYA+ D  V G C C GHA
Sbjct: 218 DPYSPRIQNLLKITNLRIKFVKLHTLGDNLLDSRMEIREKYYYAVYDMVVRGNCFCYGHA 277

Query: 293 SEC-----MKNEFDKLV---CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDC 344
           SEC        E + +V   C C+HNT G++CE C+ F++D PWR A   +++ C  C+C
Sbjct: 278 SECAPVDGFNEEVEGMVHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNC 337

Query: 345 NGRSQECYFDPELYRSTGH--GGHCTNCQDNTDGAHCERCRENFFR-----LGNNEACSS 397
           N  S  C+FD  +Y +TG+  GG C +CQ NT G +CE+C+  +++     + +   C  
Sbjct: 338 NEHSISCHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCER 397

Query: 398 CHCSPVGSLSTQ-CDSY---------GRCSCKPGVMGDKCDRCQPGFHSLTEA---GCRP 444
           C C P GS +   CDSY         G+C CK  V G+ CD C+ GF+ L+     GC+ 
Sbjct: 398 CTCDPAGSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGCKS 457

Query: 445 CSCDPSGSI---DECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFC 497
           C+C+P G+I   + C+ ETG C CK  V G +C++C P  + L S++  GC PC C
Sbjct: 458 CACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGL-SNDLDGCRPCDC 512



 Score =  155 bits (393), Expect = 2e-37
 Identities = 109/338 (32%), Positives = 152/338 (44%), Gaps = 63/338 (18%)

Query: 773  CPCPG-GSSCAVVPKTKEVV-------CTNCPTGTTGKRCELCDDGYFGDPL----GRNG 820
            C C G  S CA V    E V       C  C   T G  CELC D Y   P     GRN 
Sbjct: 271  CFCYGHASECAPVDGFNEEVEGMVHGHCM-CRHNTKGLNCELCMDFYHDLPWRPAEGRNS 329

Query: 821  PVRLCRLCQCSDNIDPN--------AVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNP 872
                C+ C C+++            A GN +   G C  C +NT G  C++CK  ++ +P
Sbjct: 330  --NACKKCNCNEHSISCHFDMAVYLATGNVSG--GVCDDCQHNTMGRNCEQCKPFYYQHP 385

Query: 873  LAP-NPADKCKACNCNLYGTMKQ-------QSSCNPVTGQCECLPHVTGQDCGACDPGFY 924
                   + C+ C C+  G+  +         S   + GQC C  +V G+ C  C  GFY
Sbjct: 386  ERDIRDPNFCERCTCDPAGSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFY 445

Query: 925  NLQSGQ--GCERCDCHALGSTNG--QCDIRTGQCECQPGITGQHCERCEVNHFGFGP--E 978
            +L S    GC+ C C+ LG+  G   CD  TG C C+  +TGQHC++C   H+G     +
Sbjct: 446  DLSSEDPFGCKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLSNDLD 505

Query: 979  GCKPCDCHPEGSLSLQC-KDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPACYRL 1037
            GC+PCDC   G+L+  C  + G+C CR   +G +C++ E  Y++                
Sbjct: 506  GCRPCDCDLGGALNNSCFAESGQCSCRPHMIGRQCNEVEPGYYF---------------- 549

Query: 1038 VKDKVADHRVKLQELESLIANLGTGDEMVTDQAFEDRL 1075
                  DH   L E E   ANLG G  +V  Q  +DR+
Sbjct: 550  ---ATLDH--YLYEAEE--ANLGPGVSIVERQYIQDRI 580



 Score =  150 bits (380), Expect = 7e-36
 Identities = 94/282 (33%), Positives = 123/282 (43%), Gaps = 36/282 (12%)

Query: 724 CACNGHSETCDPETGV-----------CNCRDNTAGPHCEKCSDGYYG----DSTAGTSS 768
           C C GH+  C P  G            C CR NT G +CE C D Y+      +    S+
Sbjct: 271 CFCYGHASECAPVDGFNEEVEGMVHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSN 330

Query: 769 DCQPCPCPGGS-SC----AVVPKTKEV---VCTNCPTGTTGKRCELCDDGYFGDPLGRNG 820
            C+ C C   S SC    AV   T  V   VC +C   T G+ CE C   Y+  P     
Sbjct: 331 ACKKCNCNEHSISCHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIR 390

Query: 821 PVRLCRLCQCSDNIDPNAVGNCNRLT--------GECLKCIYNTAGFYCDRCKDGFFGNP 872
               C  C C      N  G C+  T        G+C +C  N  G +CD CK+GF+   
Sbjct: 391 DPNFCERCTCDPAGSQNE-GICDSYTDFSTGLIAGQC-RCKLNVEGEHCDVCKEGFYD-- 446

Query: 873 LAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSG-QG 931
           L+      CK+C CN  GT+   + C+  TG C C   VTGQ C  C P  + L +   G
Sbjct: 447 LSSEDPFGCKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLSNDLDG 506

Query: 932 CERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHF 973
           C  CDC   G+ N  C   +GQC C+P + G+ C   E  ++
Sbjct: 507 CRPCDCDLGGALNNSCFAESGQCSCRPHMIGRQCNEVEPGYY 548



 Score =  136 bits (342), Expect = 2e-31
 Identities = 77/219 (35%), Positives = 109/219 (49%), Gaps = 25/219 (11%)

Query: 285 RCKCNGHASECMKNEFDKLVC------------NCKHNTYGVDCEKCLPFFNDRPWRRAT 332
           +C CN H+  C    FD  V             +C+HNT G +CE+C PF+   P R   
Sbjct: 334 KCNCNEHSISC---HFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIR 390

Query: 333 AESASECLPCDCNGRSQECYFDPELYRSTGH-GGHCTNCQDNTDGAHCERCRENFFRLGN 391
             +  E   CD  G   E   D     STG   G C  C+ N +G HC+ C+E F+ L +
Sbjct: 391 DPNFCERCTCDPAGSQNEGICDSYTDFSTGLIAGQC-RCKLNVEGEHCDVCKEGFYDLSS 449

Query: 392 NE--ACSSCHCSPVGSL--STQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEA--GCRP 444
            +   C SC C+P+G++     CDS  G C CK  V G  CD+C P    L+    GCRP
Sbjct: 450 EDPFGCKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLSNDLDGCRP 509

Query: 445 CSCDPSGSIDE-CNIETGRCVCKDNVEGFNCERCKPGFF 482
           C CD  G+++  C  E+G+C C+ ++ G  C   +PG++
Sbjct: 510 CDCDLGGALNNSCFAESGQCSCRPHMIGRQCNEVEPGYY 548



 Score =  122 bits (305), Expect = 4e-27
 Identities = 84/271 (30%), Positives = 116/271 (42%), Gaps = 42/271 (15%)

Query: 683  PATWVESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSET-----CDPET 737
            P T   +C C  GY G  C+ C SGY      +G    C  C C+ + +T     CD ET
Sbjct: 937  PVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVG--GSCQPCQCHNNIDTTDPEACDKET 994

Query: 738  GVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCP---------GGSSCAVVPKT 787
            G C  C  +T G HC+ C  GYYGD+      DC+ C C           GS C     T
Sbjct: 995  GRCLKCLYHTEGEHCQFCRFGYYGDA---LQQDCRKCVCNYLGTVQEHCNGSDCQCDKAT 1051

Query: 788  KEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTG 847
             + +C        G+ C+ C    +    G       C  C C  N   +   +CN  TG
Sbjct: 1052 GQCLCL---PNVIGQNCDRCAPNTWQLASGTG-----CDPCNC--NAAHSFGPSCNEFTG 1101

Query: 848  ECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCEC 907
            +C +C+    G  C  C++ F+G+P       +C+AC+C+  G    Q  C+  TGQC C
Sbjct: 1102 QC-QCMPGFGGRTCSECQELFWGDPDV-----ECRACDCDPRGIETPQ--CDQSTGQCVC 1153

Query: 908  LPHVTGQDCGACDPGFYNLQSGQGCERCDCH 938
            +  V G  C  C  G+    SG   +   CH
Sbjct: 1154 VEGVEGPRCDKCTRGY----SGVFPDCTPCH 1180



 Score =  112 bits (279), Expect = 4e-24
 Identities = 73/231 (31%), Positives = 104/231 (45%), Gaps = 30/231 (12%)

Query: 282  VGGRCK---CNGHASECMKNEFDKLV---CNCKHNTYGVDCEKC-LPFFNDRPWRRATAE 334
            VGG C+   C+ +         DK       C ++T G  C+ C   ++ D         
Sbjct: 969  VGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYHTEGEHCQFCRFGYYGDA-------- 1020

Query: 335  SASECLPCDCN--GRSQE-CY-FDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLG 390
               +C  C CN  G  QE C   D +  ++TG    C  C  N  G +C+RC  N ++L 
Sbjct: 1021 LQQDCRKCVCNYLGTVQEHCNGSDCQCDKATGQ---CL-CLPNVIGQNCDRCAPNTWQLA 1076

Query: 391  NNEACSSCHCSPVGSLSTQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDP 449
            +   C  C+C+   S    C+ + G+C C PG  G  C  CQ  F    +  CR C CDP
Sbjct: 1077 SGTGCDPCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCSECQELFWGDPDVECRACDCDP 1136

Query: 450  SG-SIDECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCF-CF 498
             G    +C+  TG+CVC + VEG  C++C  G+  +       CTPC  CF
Sbjct: 1137 RGIETPQCDQSTGQCVCVEGVEGPRCDKCTRGYSGVFPD----CTPCHQCF 1183



 Score =  111 bits (278), Expect = 5e-24
 Identities = 66/210 (31%), Positives = 86/210 (40%), Gaps = 66/210 (31%)

Query: 883  ACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGS 942
            AC C+  G++   S C+P  GQC+C P+V G+ C  C PG +      GC+ C+CH  GS
Sbjct: 772  ACECDPQGSLS--SVCDPNGGQCQCRPNVVGRTCNRCAPGTFGF-GPSGCKPCECHLQGS 828

Query: 943  TNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPC-------DCHPEGSLSLQC 995
             N  C+  TGQC C  G+  + C+RC   H+GF    C+PC       DC P     L C
Sbjct: 829  VNAFCNPVTGQCHCFQGVYARQCDRCLPGHWGF--PSCQPCQCNGHADDCDPVTGECLNC 886

Query: 996  KD--------------------------------DG--------------------RCEC 1003
            +D                                DG                     C C
Sbjct: 887  QDYTMGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQLACVC 946

Query: 1004 REGFVGNRCDQCEENYFYNRSWPG--CQEC 1031
              G++G+RCD C   YF N S  G  CQ C
Sbjct: 947  DPGYIGSRCDDCASGYFGNPSEVGGSCQPC 976



 Score =  110 bits (275), Expect = 1e-23
 Identities = 77/264 (29%), Positives = 112/264 (42%), Gaps = 42/264 (15%)

Query: 690 CTCPVGYGGQFCEMCLSGYRRET--PNLGPYS-PCVLCACNGHSETC-----------DP 735
           C C     G  CE+C+  Y      P  G  S  C  C CN HS +C           + 
Sbjct: 298 CMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCNEHSISCHFDMAVYLATGNV 357

Query: 736 ETGVC-NCRDNTAGPHCEKCSDGYY--GDSTAGTSSDCQPCPC-PGGSSCAVVPKTKEVV 791
             GVC +C+ NT G +CE+C   YY   +      + C+ C C P GS    +  +    
Sbjct: 358 SGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGICDSYTDF 417

Query: 792 CT-------NCPTGTTGKRCELCDDGYFG----DPLGRNGPVRLCRLCQCSDNIDPNAVG 840
            T        C     G+ C++C +G++     DP G       C+ C C+         
Sbjct: 418 STGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFG-------CKSCACNPLGTIPGGN 470

Query: 841 NCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNP 900
            C+  TG C  C     G +CD+C    +G     N  D C+ C+C+L G +   +SC  
Sbjct: 471 PCDSETGHCY-CKRLVTGQHCDQCLPEHWG---LSNDLDGCRPCDCDLGGAL--NNSCFA 524

Query: 901 VTGQCECLPHVTGQDCGACDPGFY 924
            +GQC C PH+ G+ C   +PG+Y
Sbjct: 525 ESGQCSCRPHMIGRQCNEVEPGYY 548



 Score =  109 bits (273), Expect = 2e-23
 Identities = 77/272 (28%), Positives = 109/272 (40%), Gaps = 71/272 (26%)

Query: 286  CKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDC- 344
            C+CNGHA +C     + L  NC+  T G +CE+CL  +   P       S   C PC C 
Sbjct: 867  CQCNGHADDCDPVTGECL--NCQDYTMGHNCERCLAGYYGDP----IIGSGDHCRPCPCP 920

Query: 345  ----NGR--SQECYFDPELYR-----------------STGH-------GGHCTNCQ--- 371
                +GR  ++ CY DP   +                 ++G+       GG C  CQ   
Sbjct: 921  DGPDSGRQFARSCYQDPVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHN 980

Query: 372  --DNTD-------------------GAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQC 410
              D TD                   G HC+ CR  ++     + C  C C+ +G++   C
Sbjct: 981  NIDTTDPEACDKETGRCLKCLYHTEGEHCQFCRFGYYGDALQQDCRKCVCNYLGTVQEHC 1040

Query: 411  D--------SYGRCSCKPGVMGDKCDRCQPGFHSLTE-AGCRPCSCDPSGSI-DECNIET 460
            +        + G+C C P V+G  CDRC P    L    GC PC+C+ + S    CN  T
Sbjct: 1041 NGSDCQCDKATGQCLCLPNVIGQNCDRCAPNTWQLASGTGCDPCNCNAAHSFGPSCNEFT 1100

Query: 461  GRCVCKDNVEGFNCERCKPGFFNLESSNPRGC 492
            G+C C     G  C  C+  F+       R C
Sbjct: 1101 GQCQCMPGFGGRTCSECQELFWGDPDVECRAC 1132



 Score =  106 bits (264), Expect = 2e-22
 Identities = 66/212 (31%), Positives = 94/212 (44%), Gaps = 40/212 (18%)

Query: 305  CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHG 364
            C+C    Y   C++CLP     P           C PC CNG + +C  DP         
Sbjct: 840  CHCFQGVYARQCDRCLPGHWGFP----------SCQPCQCNGHADDC--DPVT------- 880

Query: 365  GHCTNCQDNTDGAHCERCRENFFR---LGNNEACSSCHC--SPVGSLSTQCDSYG----- 414
            G C NCQD T G +CERC   ++    +G+ + C  C C   P          Y      
Sbjct: 881  GECLNCQDYTMGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTL 940

Query: 415  --RCSCKPGVMGDKCDRCQPG-FHSLTEAG--CRPCSCD---PSGSIDECNIETGRCV-C 465
               C C PG +G +CD C  G F + +E G  C+PC C     +   + C+ ETGRC+ C
Sbjct: 941  QLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKC 1000

Query: 466  KDNVEGFNCERCKPGFFNLESSNPRGCTPCFC 497
              + EG +C+ C+ G++    +  + C  C C
Sbjct: 1001 LYHTEGEHCQFCRFGYYG--DALQQDCRKCVC 1030



 Score =  105 bits (262), Expect = 4e-22
 Identities = 51/132 (38%), Positives = 69/132 (52%), Gaps = 9/132 (6%)

Query: 382 CRENFFRLGN--NEACSSCHCSPVGSLSTQCD-SYGRCSCKPGVMGDKCDRCQPGFHSLT 438
           CR   F +    ++   +C C P GSLS+ CD + G+C C+P V+G  C+RC PG     
Sbjct: 755 CRNIIFSISALLHQTGLACECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNRCAPGTFGFG 814

Query: 439 EAGCRPCSCDPSGSIDE-CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFC 497
            +GC+PC C   GS++  CN  TG+C C   V    C+RC PG +   S     C PC C
Sbjct: 815 PSGCKPCECHLQGSVNAFCNPVTGQCHCFQGVYARQCDRCLPGHWGFPS-----CQPCQC 869

Query: 498 FGHSSVCTNAVG 509
            GH+  C    G
Sbjct: 870 NGHADDCDPVTG 881


>gi|5453810 netrin 3 [Homo sapiens]
          Length = 580

 Score =  327 bits (837), Expect = 7e-89
 Identities = 176/444 (39%), Positives = 238/444 (53%), Gaps = 34/444 (7%)

Query: 18  WPVLAVLAA----AAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFNVTVVATNTCGTPP 73
           WP   +L A    AA +    A  D C DEGG P+ C+P  VNAA    V+A++TCG P 
Sbjct: 4   WPWGLLLTAGTLFAALSPGPPAPADPCHDEGGAPRGCVPGLVNAALGREVLASSTCGRP- 62

Query: 74  EEYCVQTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQYPSSI 133
                         +   CDA  P   H  A LT     A    W+S+++    + P ++
Sbjct: 63  --------------ATRACDASDPRRAHSPALLTSPGGTASPLCWRSESL---PRAPLNV 105

Query: 134 NLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGF 193
            LT+ LGKAF++ +V L+F ++ P S A+ K       W P  ++S  C+  Y +     
Sbjct: 106 TLTVPLGKAFELVFVSLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLPAPA 165

Query: 194 IRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTL 253
               G   +ALC        P   G +AFS  +  P   + D+SPVLQ+WVTATD+RV L
Sbjct: 166 NGPAGPGPEALCFPA-PLAQPDGSGLLAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVL 224

Query: 254 NRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEFDKLVCNCKHNTYG 313
            R +T GD    D + +  Y YA +D  VGGRCKCNGHAS C+ +    L+C+C+H T G
Sbjct: 225 TRPSTAGDP--RDMEAVVPYSYAATDLQVGGRCKCNGHASRCLLDTQGHLICDCRHGTEG 282

Query: 314 VDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGH--GGHCTNCQ 371
            DC +C PF+ DRPW+RATA  +  CL C CNG ++ C F+ ELYR +G   GG C NC+
Sbjct: 283 PDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCR 342

Query: 372 DNTDGAHCERCRENFFR-----LGNNEACSSCHCSPVGSLSTQCD-SYGRCSCKPGVMGD 425
            NT G HC  CRE F+R     L +  AC +C C PVG+    C+ + G+C CK GV G 
Sbjct: 343 HNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGL 402

Query: 426 KCDRCQPGFHSLTEAGCRPCSCDP 449
            C+RC PGF   + +   PC   P
Sbjct: 403 TCNRCAPGFQQ-SRSPVAPCVKTP 425



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 67/230 (29%), Positives = 91/230 (39%), Gaps = 41/230 (17%)

Query: 724 CACNGHSETCDPETG---VCNCRDNTAGPHCEKCSDGY----YGDSTAGTSSDCQPCPCP 776
           C CNGH+  C  +T    +C+CR  T GP C +C   Y    +  +TA  S  C  C C 
Sbjct: 255 CKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCN 314

Query: 777 GGSSCA--------VVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLC 828
           G +           +  +    VC NC   T G+ C  C +G++ DP       R CR C
Sbjct: 315 GHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRAC 374

Query: 829 QCSDNIDPNAVG-NCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCN 887
            C       A G  CN+ TG+C  C     G  C+RC  GF  +     P  K       
Sbjct: 375 DCH---PVGAAGKTCNQTTGQC-PCKDGVTGLTCNRCAPGFQQSRSPVAPCVK------- 423

Query: 888 LYGTMKQQSSCNPVTGQCECLPHVTGQDCGA-CDP--GFYNLQSGQGCER 934
                       P+ G  E    V  QDC + C P  G Y +   + C++
Sbjct: 424 -----------TPIPGPTEDSSPVQPQDCDSHCKPARGSYRISLKKFCKK 462



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 48/156 (30%), Positives = 62/156 (39%), Gaps = 34/156 (21%)

Query: 842 CNRLTGECL---------KCIYNTAGFYCDRCKDGFFGNP---LAPNPADKCKACNCN-- 887
           CN     CL          C + T G  C RCK  +   P        +  C AC+CN  
Sbjct: 257 CNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGH 316

Query: 888 ---------LYGTMKQQSSCNPVTGQC-ECLPHVTGQDCGACDPGFYN-----LQSGQGC 932
                    LY    ++S      G C  C  +  G+ C  C  GFY      L   + C
Sbjct: 317 ARRCRFNMELYRLSGRRSG-----GVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRAC 371

Query: 933 ERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERC 968
             CDCH +G+    C+  TGQC C+ G+TG  C RC
Sbjct: 372 RACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRC 407



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 48/144 (33%), Positives = 58/144 (40%), Gaps = 28/144 (19%)

Query: 690 CTCPVGYGGQFCEMCLSGY-----RRETPNLGPYSPCVLCACNGHSETC----------- 733
           C C  G  G  C  C   Y     +R T        C+ C+CNGH+  C           
Sbjct: 274 CDCRHGTEGPDCGRCKPFYCDRPWQRATARES--HACLACSCNGHARRCRFNMELYRLSG 331

Query: 734 DPETGVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSS--DCQPCPC-PGGSSCAVVPKTKE 789
               GVC NCR NTAG HC  C +G+Y D     S    C+ C C P G++     KT  
Sbjct: 332 RRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAA----GKTCN 387

Query: 790 VVCTNCP--TGTTGKRCELCDDGY 811
                CP   G TG  C  C  G+
Sbjct: 388 QTTGQCPCKDGVTGLTCNRCAPGF 411



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 39/146 (26%), Positives = 56/146 (38%), Gaps = 29/146 (19%)

Query: 905  CECLPHVTGQDCGACDPGFY--------NLQSGQGCERCDCHA----------LGSTNGQ 946
            C+C     G DCG C P FY          +    C  C C+           L   +G+
Sbjct: 274  CDCRHGTEGPDCGRCKP-FYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGR 332

Query: 947  CDIRTGQC-ECQPGITGQHCERCEVNHFG------FGPEGCKPCDCHPEGSLSLQCKDD- 998
                 G C  C+    G+HC  C    +            C+ CDCHP G+    C    
Sbjct: 333  RS--GGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTT 390

Query: 999  GRCECREGFVGNRCDQCEENYFYNRS 1024
            G+C C++G  G  C++C   +  +RS
Sbjct: 391  GQCPCKDGVTGLTCNRCAPGFQQSRS 416


>gi|143770880 laminin, beta 4 [Homo sapiens]
          Length = 1761

 Score =  312 bits (800), Expect = 1e-84
 Identities = 253/958 (26%), Positives = 422/958 (44%), Gaps = 127/958 (13%)

Query: 690  CTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVC-NCRDNTAG 748
            C C     G+ C+ CL+GY         +  C  C CN  +E CDPETG C NC   T G
Sbjct: 836  CPCHGEVSGRRCDRCLAGYFG-------FPSCHPCPCNRFAELCDPETGSCFNCGGFTTG 888

Query: 749  PHCEKCSDGYYGDSTAGTSSDCQPCPCPG--------GSSCAVVPKTKEVVCTNCPTGTT 800
             +CE+C DGYYG+ ++G    C+PC CP           SC     + +V+C NC  G T
Sbjct: 889  RNCERCIDGYYGNPSSG--QPCRPCLCPDDPSSNQYFAHSCYQNLWSSDVIC-NCLQGYT 945

Query: 801  GKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFY 860
            G +C  C  G++G+P     P   C+ C C++NID     +C+R+TGECL+C++NT G  
Sbjct: 946  GTQCGECSTGFYGNPRISGAP---CQPCACNNNIDVTDPESCSRVTGECLRCLHNTQGAN 1002

Query: 861  CDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSS-------CNPVTGQCECLPHVTG 913
            C  CK G +G+ L       C+ C+C+  G    +         C+PVTG C CLP+VTG
Sbjct: 1003 CQLCKPGHYGSALNQT----CRRCSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTG 1058

Query: 914  QDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHF 973
              C  C  G++NL  G+GC+ CDC    S +  CD  TGQC C+ G  G+ C  C+ N++
Sbjct: 1059 LACDRCADGYWNLVPGRGCQSCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYY 1118

Query: 974  GFGPEGCKPCDCHPEGSLSLQCKDD-GRCECREGFVGNRCDQCEENYFYNRSWPGCQECP 1032
            G  P  C PCDC+  G+    C  D G C CREG  G RCD+C   +  ++ +P C +C 
Sbjct: 1119 GDPPGRCIPCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGH--SQEFPTCLQCH 1176

Query: 1033 ACYRLVKDKVADHRVKLQELESLIANLGTGDEM--VTDQAFEDRLKEAEREVMDLLREAQ 1090
             C+      ++     +Q L  L AN+    E   V +  F+D L+    E+  +L+   
Sbjct: 1177 LCFDQWDHTISSLSKAVQGLMRLAANMEDKRETLPVCEADFKD-LRGNVSEIERILKHPV 1235

Query: 1091 -------DVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGN----LAEQARAHV- 1138
                    VKD   ++  ++ ++N  L + +   Q++++TIE   N    L E  +  + 
Sbjct: 1236 FPSGKFLKVKDYHDSVRRQIMQLNEQLKA-VYEFQDLKDTIERAKNEADLLLEDLQEEID 1294

Query: 1139 --------------ENTERLIEIASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEAR 1184
                          EN ++   I+S   +K    ++ ++ +          +  L  +  
Sbjct: 1295 LQSSVLNASIADSSENIKKYYHISSSAEKKINETSSTINTSANTRNDLLTILDTLTSKGN 1354

Query: 1185 KLAERHKQEADDIVRVA--KTANDTSTEAYNLLL------------RTLAGENQTAFEIE 1230
               ER KQ     +++   K   D        L             R   G         
Sbjct: 1355 LSLERLKQIKIPDIQILNEKVCGDPGNVPCVPLPCGGALCTGRKGHRKCRGPGCHGSLTL 1414

Query: 1231 ELN--RKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLSPLDSETLENEANN 1288
              N  +K ++AK+I ++L+KQ   +  + +   ++A     +  QL     E L N  N 
Sbjct: 1415 STNALQKAQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLR----EKLGNIRNQ 1470

Query: 1289 IKMEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQQTADQLLARADAAKAL 1348
               E EN+   I +K+K++  L E++  +++E        K      D  L     ++ L
Sbjct: 1471 SDSEEENINLFI-KKVKNFL-LEENVPPEDIE--------KVANGVLDIHLPIP--SQNL 1518

Query: 1349 AEEAAKKGRDTLQEANDILNNLKDFDRRVNDNKTAAEEALRKIPAINQT---ITEANEKT 1405
             +E  K     +Q+   +  + +  + R+N+    A++ L K  A  +    +   ++  
Sbjct: 1519 TDELVK-----IQKHMQLCEDYRTDENRLNEEADGAQKLLVKAKAAEKAANILLNLDKTL 1573

Query: 1406 REAQQA-LGSAAADATEAKNKAHEAERIASAVQKNATSTKAEAERTFAEVTDLDNEVNNM 1464
             + QQA +    A++T  +  A+      + ++KN    + +     +E+ +L  + + +
Sbjct: 1574 NQLQQAQITQGRANSTITQLTAN-----ITKIKKNVLQAENQTREMKSEL-ELAKQRSGL 1627

Query: 1465 LKQLQEAEKELKRKQDDADQDMMMAGMASQAAQEAEINARKAKNSV------TSLLSIIN 1518
               L   + +L+R QD A    + A  A   A   E    + K         TS   +  
Sbjct: 1628 EDGLSLLQTKLQRHQDHAVNAKVQAESAQHQAGSLEKEFVELKKQYAILQRKTSTTGLTK 1687

Query: 1519 DLLEQLGQLDTVDLNKLNEIEGTLNKAKDEMKVSDLDRKVSD--LENEAKKQEAAIMD 1574
            + L ++ QL         + E  + +      ++DL+RK+ D  L  +AK  +  I++
Sbjct: 1688 ETLGKVKQLKDAAEKLAGDTEAKIRR------ITDLERKIQDLNLSRQAKADQLRILE 1739



 Score =  287 bits (734), Expect = 7e-77
 Identities = 166/496 (33%), Positives = 254/496 (51%), Gaps = 66/496 (13%)

Query: 60  NVTVVATNTCG-TPPEEYCVQTGVTGVTKSCHLCDA-------GQPHLQHGAAFLTDYNN 111
           N  ++A++TCG +  ++YC+ + + G  K C +CD+        QP+       +  +  
Sbjct: 40  NTQLMASSTCGLSRAQKYCILSYLEGEQK-CFICDSRFPYDPYDQPNSHTIENVIVSFEP 98

Query: 112 QADTTWWQSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGP 171
             +  WWQS+  L        +++ L L   F  +++ L F T RP +  + + T     
Sbjct: 99  DREKKWWQSENGL------DHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHN 152

Query: 172 WIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSA 231
           W  ++Y++  C  ++     G  +  GD    +C  ++SDI P TGG V    L+    +
Sbjct: 153 WKVFKYFAKDCATSFPNITSGQAQGVGD---IVCDSKYSDIEPSTGGEVVLKVLD---PS 206

Query: 232 YNFDN--SPVLQEWVTATDIRVTLNRLNTFGDEVF----NDPKVLKSYYYAISDFAVGGR 285
           +  +N  SP +Q+ VT T++R+   +L+T GD +     ND   L  YYYA+ +  V G 
Sbjct: 207 FEIENPYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQNDS--LDKYYYALYEMIVRGS 264

Query: 286 CKCNGHASEC---MKNEFDKLV--------CNCKHNTYGVDCEKCLPFFNDRPWRRATAE 334
           C CNGHASEC    K   D           C C+HNT G +CE+C  FF D PWR A   
Sbjct: 265 CFCNGHASECRPMQKMRGDVFSPPGMVHGQCVCQHNTDGPNCERCKDFFQDAPWRPAADL 324

Query: 335 SASECLPCDCNGRSQECYFDPELYRSTG--HGGHCTNCQDNTDGAHCERCRENFFR---- 388
             + C  C CN  S  C+FD   Y ++G   GG C +CQ NT+G HC+RCR  F+R    
Sbjct: 325 QDNACRSCSCNSHSSRCHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLK 384

Query: 389 -LGNNEACSSCHCSPVGSLSTQ-CDSY---------GRCSCKPGVMGDKCDRCQPGFHSL 437
            + +  AC  C C P G++S   C S+         G+C CK  V G KCD+C+P  + L
Sbjct: 385 TISDPYACIPCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCKPNHYGL 444

Query: 438 TEA---GCRPCSCDPSGSID--ECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGC 492
           +     GC+PC C+P GS+    C+++TG+C+C   V G +CE C  G++ L  ++  GC
Sbjct: 445 SATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHCEECTVGYWGL-GNHLHGC 503

Query: 493 TPCFC---FGHSSVCT 505
           +PC C     +S+VC+
Sbjct: 504 SPCDCDIGGAYSNVCS 519



 Score =  147 bits (372), Expect = 6e-35
 Identities = 93/293 (31%), Positives = 133/293 (45%), Gaps = 49/293 (16%)

Query: 724 CACNGHSETCDPET--------------GVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSD 769
           C CNGH+  C P                G C C+ NT GP+CE+C D ++ D+    ++D
Sbjct: 265 CFCNGHASECRPMQKMRGDVFSPPGMVHGQCVCQHNTDGPNCERCKD-FFQDAPWRPAAD 323

Query: 770 -----CQPCPCPGGSSCAVVPKTKEV--------VCTNCPTGTTGKRCELCDDGYFGDPL 816
                C+ C C   SS      T  +        VC +C   T G+ C+ C   ++ DPL
Sbjct: 324 LQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPL 383

Query: 817 GRNGPVRLCRLCQCSDNIDPNAV---GNC--------NRLTGECLKCIYNTAGFYCDRCK 865
                   C  C+C    DP+     G C          + G+CL C  N  G  CD+CK
Sbjct: 384 KTISDPYACIPCEC----DPDGTISGGICVSHSDPALGSVAGQCL-CKENVEGAKCDQCK 438

Query: 866 DGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYN 925
              +G  L+      C+ C+CN  G++   + C+  TGQC CL +VTG  C  C  G++ 
Sbjct: 439 PNHYG--LSATDPLGCQPCDCNPLGSLPFLT-CDVDTGQCLCLSYVTGAHCEECTVGYWG 495

Query: 926 LQSG-QGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGP 977
           L +   GC  CDC   G+ +  C  + GQCEC+P +TG+ C      +F F P
Sbjct: 496 LGNHLHGCSPCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYF-FAP 547



 Score =  146 bits (369), Expect = 1e-34
 Identities = 92/279 (32%), Positives = 123/279 (44%), Gaps = 24/279 (8%)

Query: 765  GTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVR- 823
            G +S+C+P     G   +  P      C  C   T G  CE C D +   P      ++ 
Sbjct: 269  GHASECRPMQKMRGDVFSP-PGMVHGQCV-CQHNTDGPNCERCKDFFQDAPWRPAADLQD 326

Query: 824  -LCRLCQCSDNIDPNAVGNCNRLT------GECLKCIYNTAGFYCDRCKDGFFGNPLAP- 875
              CR C C+ +           L       G C  C +NT G +CDRC+  F+ +PL   
Sbjct: 327  NACRSCSCNSHSSRCHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTI 386

Query: 876  NPADKCKACNCNLYGTMK-------QQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQS 928
            +    C  C C+  GT+           +   V GQC C  +V G  C  C P  Y L +
Sbjct: 387  SDPYACIPCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCKPNHYGLSA 446

Query: 929  GQ--GCERCDCHALGSTNG-QCDIRTGQCECQPGITGQHCERCEVNHFGFGPE--GCKPC 983
                GC+ CDC+ LGS     CD+ TGQC C   +TG HCE C V ++G G    GC PC
Sbjct: 447  TDPLGCQPCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGCSPC 506

Query: 984  DCHPEGSLSLQCKD-DGRCECREGFVGNRCDQCEENYFY 1021
            DC   G+ S  C   +G+CECR    G  C +    YF+
Sbjct: 507  DCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFF 545



 Score =  116 bits (290), Expect = 2e-25
 Identities = 84/275 (30%), Positives = 117/275 (42%), Gaps = 65/275 (23%)

Query: 690 CTCPVGYGGQFCEMCLSGYRRETPNLGPYSP--------CVLCACNGHSETC--DPET-- 737
           C C     G  CE C   ++       P+ P        C  C+CN HS  C  D  T  
Sbjct: 295 CVCQHNTDGPNCERCKDFFQD-----APWRPAADLQDNACRSCSCNSHSSRCHFDMTTYL 349

Query: 738 -------GVC-NCRDNTAGPHCEKCSDGYYGD--STAGTSSDCQPCPC-PGGSSCAVV-- 784
                  GVC +C+ NT G HC++C   +Y D   T      C PC C P G+    +  
Sbjct: 350 ASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGGICV 409

Query: 785 ----PKTKEVV--CTNCPTGTTGKRCELCDDGYFG----DPLGRNGPVRLCRLCQCSDNI 834
               P    V   C  C     G +C+ C   ++G    DPLG       C+ C C    
Sbjct: 410 SHSDPALGSVAGQCL-CKENVEGAKCDQCKPNHYGLSATDPLG-------CQPCDC---- 457

Query: 835 DPNAVGN-----CNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLY 889
             N +G+     C+  TG+CL C+    G +C+ C  G++G     N    C  C+C++ 
Sbjct: 458 --NPLGSLPFLTCDVDTGQCL-CLSYVTGAHCEECTVGYWG---LGNHLHGCSPCDCDIG 511

Query: 890 GTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFY 924
           G     + C+P  GQCEC PHVTG+ C    PG++
Sbjct: 512 GA--YSNVCSPKNGQCECRPHVTGRSCSEPAPGYF 544



 Score =  111 bits (277), Expect = 6e-24
 Identities = 70/239 (29%), Positives = 102/239 (42%), Gaps = 34/239 (14%)

Query: 288  CNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFN----DRPWRRATAESASECLPCD 343
            C+    EC++         C HNT G +C+ C P       ++  RR +   AS   P +
Sbjct: 984  CSRVTGECLR---------CLHNTQGANCQLCKPGHYGSALNQTCRRCSCH-ASGVSPME 1033

Query: 344  CNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPV 403
            C      C  DP         G C  C  N  G  C+RC + ++ L     C SC C P 
Sbjct: 1034 CPPGGGACLCDPVT-------GACP-CLPNVTGLACDRCADGYWNLVPGRGCQSCDCDPR 1085

Query: 404  GSLSTQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDE-CNIETG 461
             S S+ CD   G+C CK G  G +C  CQ  ++      C PC C+ +G+    C+ +TG
Sbjct: 1086 TSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRCIPCDCNRAGTQKPICDPDTG 1145

Query: 462  RCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQ 520
             C C++ V G  C+RC  G     S     C  C       +C +   +++ S+S   Q
Sbjct: 1146 MCRCREGVSGQRCDRCARG----HSQEFPTCLQC------HLCFDQWDHTISSLSKAVQ 1194



 Score =  110 bits (274), Expect = 1e-23
 Identities = 70/215 (32%), Positives = 98/215 (45%), Gaps = 31/215 (14%)

Query: 847  GECLKCIYNTAGFYCDRCKDGFFGNPLAPNPA---DKCKACNCNLYGTM------KQQSS 897
            G+C+ C +NT G  C+RCKD F   P  P      + C++C+CN + +          +S
Sbjct: 293  GQCV-CQHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHFDMTTYLAS 351

Query: 898  CNPVTGQCECLPHVT-GQDCGACDPGFYN-----LQSGQGCERCDCHALGSTNGQCDIR- 950
                 G CE   H T GQ C  C P FY      +     C  C+C   G+ +G   +  
Sbjct: 352  GGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGGICVSH 411

Query: 951  --------TGQCECQPGITGQHCERCEVNHFGFG---PEGCKPCDCHPEGSLS-LQCK-D 997
                     GQC C+  + G  C++C+ NH+G     P GC+PCDC+P GSL  L C  D
Sbjct: 412  SDPALGSVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVD 471

Query: 998  DGRCECREGFVGNRCDQCEENYF-YNRSWPGCQEC 1031
             G+C C     G  C++C   Y+       GC  C
Sbjct: 472  TGQCLCLSYVTGAHCEECTVGYWGLGNHLHGCSPC 506



 Score =  107 bits (267), Expect = 9e-23
 Identities = 59/157 (37%), Positives = 79/157 (50%), Gaps = 10/157 (6%)

Query: 879  DKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCH 938
            D   AC C+  G++   SSC+ + GQC+C P V G+ C  C  G Y+L    GC  C CH
Sbjct: 764  DGAVACKCHPQGSVG--SSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL-GHHGCHPCHCH 820

Query: 939  ALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDD 998
              GS +  CD  TGQC C   ++G+ C+RC   +FGF    C PC C+    L     + 
Sbjct: 821  PQGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGF--PSCHPCPCNRFAELC--DPET 876

Query: 999  GRCECREGF-VGNRCDQCEENYFYNRSWPGCQECPAC 1034
            G C    GF  G  C++C + Y+ N S    Q C  C
Sbjct: 877  GSCFNCGGFTTGRNCERCIDGYYGNPS--SGQPCRPC 911



 Score =  100 bits (248), Expect = 1e-20
 Identities = 46/126 (36%), Positives = 61/126 (48%), Gaps = 7/126 (5%)

Query: 917  GACDPGFYNLQSG--QGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFG 974
            GAC+    ++ +    G   C CH  GS    C    GQC+C+P + G+ C+RC    + 
Sbjct: 749  GACERLIISMSAKLHDGAVACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYD 808

Query: 975  FGPEGCKPCDCHPEGSLSLQCKD-DGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPA 1033
             G  GC PC CHP+GS    C    G+C C     G RCD+C   YF    +P C  CP 
Sbjct: 809  LGHHGCHPCHCHPQGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYF---GFPSCHPCP- 864

Query: 1034 CYRLVK 1039
            C R  +
Sbjct: 865  CNRFAE 870



 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 47/120 (39%), Positives = 61/120 (50%), Gaps = 7/120 (5%)

Query: 392 NEACSSCHCSPVGSLSTQCDSYG-RCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPS 450
           ++   +C C P GS+ + C   G +C CKP V+G  CDRC  G + L   GC PC C P 
Sbjct: 763 HDGAVACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDLGHHGCHPCHCHPQ 822

Query: 451 GSIDE-CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVG 509
           GS D  C+  TG+C C   V G  C+RC  G+F   S     C PC C   + +C    G
Sbjct: 823 GSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPS-----CHPCPCNRFAELCDPETG 877



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 73/247 (29%), Positives = 89/247 (36%), Gaps = 35/247 (14%)

Query: 286  CKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDC- 344
            C CN  A  C          NC   T G +CE+C+  +   P       S   C PC C 
Sbjct: 863  CPCNRFAELCDPETGSCF--NCGGFTTGRNCERCIDGYYGNP------SSGQPCRPCLCP 914

Query: 345  NGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGN----NEACSSCHC 400
            +  S   YF    Y++        NC     G  C  C   F+  GN       C  C C
Sbjct: 915  DDPSSNQYFAHSCYQNLWSSDVICNCLQGYTGTQCGECSTGFY--GNPRISGAPCQPCAC 972

Query: 401  S---PVGSLSTQCDSYGRC-SCKPGVMGDKCDRCQPGFH-SLTEAGCRPCSCD------- 448
            +    V    +     G C  C     G  C  C+PG + S     CR CSC        
Sbjct: 973  NNNIDVTDPESCSRVTGECLRCLHNTQGANCQLCKPGHYGSALNQTCRRCSCHASGVSPM 1032

Query: 449  ---PSGSIDECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFC---FGHSS 502
               P G    C+  TG C C  NV G  C+RC  G++NL     RGC  C C      SS
Sbjct: 1033 ECPPGGGACLCDPVTGACPCLPNVTGLACDRCADGYWNLVPG--RGCQSCDCDPRTSQSS 1090

Query: 503  VCTNAVG 509
             C    G
Sbjct: 1091 HCDQLTG 1097



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 50/166 (30%), Positives = 72/166 (43%), Gaps = 36/166 (21%)

Query: 901  VTGQCECLPHVTGQDCGACDPGFYNLQ-------SGQGCERCDCHALGSTNGQCDIRT-- 951
            V GQC C  +  G +C  C   F +             C  C C++  S+    D+ T  
Sbjct: 291  VHGQCVCQHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSCNS-HSSRCHFDMTTYL 349

Query: 952  -------GQCE-CQPGITGQHCERCEVNHFG------FGPEGCKPCDCHPEGSLS----L 993
                   G CE CQ    GQHC+RC    +         P  C PC+C P+G++S    +
Sbjct: 350  ASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGGICV 409

Query: 994  QCKDD------GRCECREGFVGNRCDQCEENYF-YNRSWP-GCQEC 1031
               D       G+C C+E   G +CDQC+ N++  + + P GCQ C
Sbjct: 410  SHSDPALGSVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPC 455



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 65/253 (25%), Positives = 92/253 (36%), Gaps = 43/253 (16%)

Query: 286 CKCNGHASECMKNEFDKL--VCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCD 343
           CKC  H    + +   +L   C CK    G  C++C     D             C PC 
Sbjct: 769 CKC--HPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL--------GHHGCHPCH 818

Query: 344 CNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPV 403
           C+ +  +   D    + TG       C     G  C+RC   +F         SCH  P 
Sbjct: 819 CHPQGSK---DTVCDQVTGQ----CPCHGEVSGRRCDRCLAGYF------GFPSCHPCPC 865

Query: 404 GSLSTQCD-SYGRC-SCKPGVMGDKCDRCQPGFHSLTEAG--CRPCSC--DPSGS---ID 454
              +  CD   G C +C     G  C+RC  G++    +G  CRPC C  DPS +     
Sbjct: 866 NRFAELCDPETGSCFNCGGFTTGRNCERCIDGYYGNPSSGQPCRPCLCPDDPSSNQYFAH 925

Query: 455 EC--NIETGR--CVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSV-----CT 505
            C  N+ +    C C     G  C  C  GF+     +   C PC C  +  V     C+
Sbjct: 926 SCYQNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRISGAPCQPCACNNNIDVTDPESCS 985

Query: 506 NAVGYSVYSISST 518
              G  +  + +T
Sbjct: 986 RVTGECLRCLHNT 998



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 39/126 (30%), Positives = 52/126 (41%), Gaps = 12/126 (9%)

Query: 689  SCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACN---GHSETCDPETGVCNCRDN 745
            +C C     G  C+ C  GY     NL P   C  C C+     S  CD  TG C C+  
Sbjct: 1049 ACPCLPNVTGLACDRCADGYW----NLVPGRGCQSCDCDPRTSQSSHCDQLTGQCPCKLG 1104

Query: 746  TAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCE 805
              G  C +C + YYGD        C PC C    +   +      +C  C  G +G+RC+
Sbjct: 1105 YGGKRCSECQENYYGD----PPGRCIPCDCNRAGTQKPICDPDTGMC-RCREGVSGQRCD 1159

Query: 806  LCDDGY 811
             C  G+
Sbjct: 1160 RCARGH 1165



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 44/133 (33%), Positives = 53/133 (39%), Gaps = 13/133 (9%)

Query: 690 CTCPVGYGGQFCEMCLSGYR--RETPNLGPYSPCVLCACNGHSE----TCDPETGVCNCR 743
           C C     G  C+ C   +     T  LG    C  C CN        TCD +TG C C 
Sbjct: 423 CLCKENVEGAKCDQCKPNHYGLSATDPLG----CQPCDCNPLGSLPFLTCDVDTGQCLCL 478

Query: 744 DNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKR 803
               G HCE+C+ GY+G         C PC C  G + + V   K   C  C    TG+ 
Sbjct: 479 SYVTGAHCEECTVGYWG--LGNHLHGCSPCDCDIGGAYSNVCSPKNGQC-ECRPHVTGRS 535

Query: 804 CELCDDGYFGDPL 816
           C     GYF  PL
Sbjct: 536 CSEPAPGYFFAPL 548



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 31/94 (32%), Positives = 40/94 (42%), Gaps = 7/94 (7%)

Query: 420 PGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSI-DECNIETGRCVCKDNVEGFNCERCK 478
           P V+   C+R      +    G   C C P GS+   C+   G+C CK  V G  C+RC 
Sbjct: 744 PQVLPGACERLIISMSAKLHDGAVACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCS 803

Query: 479 PGFFNLESSNPRGCTPCFCFGHSS---VCTNAVG 509
            G ++L      GC PC C    S   VC    G
Sbjct: 804 TGSYDL---GHHGCHPCHCHPQGSKDTVCDQVTG 834



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 2/88 (2%)

Query: 958  PGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQC-KDDGRCECREGFVGNRCDQCE 1016
            P +    CER  ++      +G   C CHP+GS+   C +  G+C+C+   VG  CD+C 
Sbjct: 744  PQVLPGACERLIISMSAKLHDGAVACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCS 803

Query: 1017 ENYFYNRSWPGCQECPACYRLVKDKVAD 1044
                Y+    GC  C    +  KD V D
Sbjct: 804  TG-SYDLGHHGCHPCHCHPQGSKDTVCD 830



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 71/361 (19%), Positives = 142/361 (39%), Gaps = 66/361 (18%)

Query: 1086 LREAQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTI----EETGNLAEQARAHVENT 1141
            L++AQ+ K + +NL  +++ + N + S   + +  +N      E+ GN+  Q+ +  EN 
Sbjct: 1419 LQKAQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEEENI 1478

Query: 1142 ERLIE----------IASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHK 1191
               I+          +   ++EK      ++ +  P           L +E  K+ ++H 
Sbjct: 1479 NLFIKKVKNFLLEENVPPEDIEKVANGVLDIHLPIPSQN--------LTDELVKI-QKHM 1529

Query: 1192 QEADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAA 1251
            Q  +D        N+ +  A  LL++  A                E+A NI  +L+K   
Sbjct: 1530 QLCEDYRTDENRLNEEADGAQKLLVKAKAA---------------EKAANILLNLDKTLN 1574

Query: 1252 RVHEEAKRAGDKAVEIYASVAQLSPLDSETL--ENEANNIKMEAENLEQ---------LI 1300
            ++ +     G     I    A ++ +    L  EN+   +K E E  +Q         L+
Sbjct: 1575 QLQQAQITQGRANSTITQLTANITKIKKNVLQAENQTREMKSELELAKQRSGLEDGLSLL 1634

Query: 1301 DQKLKDYEDLREDMRGKELEVKN---LLEKGKTEQQTADQLLARADAAKALAEEAAKKGR 1357
              KL+ ++D   + + +    ++    LEK   E +    +L R  +   L +E   K +
Sbjct: 1635 QTKLQRHQDHAVNAKVQAESAQHQAGSLEKEFVELKKQYAILQRKTSTTGLTKETLGKVK 1694

Query: 1358 DTLQEANDI-------LNNLKDFDRRVND---NKTAAEEALR----KIPAINQTITEANE 1403
                 A  +       +  + D +R++ D   ++ A  + LR    ++ AI   I E  +
Sbjct: 1695 QLKDAAEKLAGDTEAKIRRITDLERKIQDLNLSRQAKADQLRILEDQVVAIKNEIVEQEK 1754

Query: 1404 K 1404
            K
Sbjct: 1755 K 1755


>gi|119703755 laminin, beta 2 precursor [Homo sapiens]
          Length = 1798

 Score =  306 bits (784), Expect = 1e-82
 Identities = 253/980 (25%), Positives = 411/980 (41%), Gaps = 127/980 (12%)

Query: 690  CTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVC-NCRDNTAG 748
            C C  G  G  C+ C  G          +  C  C CNGH++ C+  TG C  CRD+T G
Sbjct: 850  CLCRTGAFGLRCDRCQRGQ-------WGFPSCRPCVCNGHADECNTHTGACLGCRDHTGG 902

Query: 749  PHCEKCSDGYYGDSTAGTSSDCQPCPCPGG--------SSCAVVPKTKEVVCTNCPTGTT 800
             HCE+C  G++GD        C+PCPCP G        +SC     ++++VC +C  G T
Sbjct: 903  EHCERCIAGFHGDPRLPYGGQCRPCPCPEGPGSQRHFATSCHQDEYSQQIVC-HCRAGYT 961

Query: 801  GKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFY 860
            G RCE C  G+FGDP   + P   C+LC+CS NIDP     C+  TG+CL+C+++T G +
Sbjct: 962  GLRCEACAPGHFGDP---SRPGGRCQLCECSGNIDPMDPDACDPHTGQCLRCLHHTEGPH 1018

Query: 861  CDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSS------CNPVTGQCECLPHVTGQ 914
            C  CK GF G     +    C  C CNL GT  QQ        C+P +GQC CLP+V G 
Sbjct: 1019 CAHCKPGFHGQAARQS----CHRCTCNLLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQGP 1074

Query: 915  DCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFG 974
             C  C P F+NL SG GC+ C CH   +    C+  TGQC C+ G  G+ C  C+  H+G
Sbjct: 1075 SCDRCAPNFWNLTSGHGCQPCACHPSRARGPTCNEFTGQCHCRAGFGGRTCSECQELHWG 1134

Query: 975  FGPEGCKPCDCHPEGSLSLQC-KDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPA 1033
                 C  CDC   G  + QC +  G C CR G  G RCDQC     ++  +P C  C A
Sbjct: 1135 DPGLQCHACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCDQCARG--FSGIFPACHPCHA 1192

Query: 1034 CYRLVKDKVADHRVKLQELESLIANL-GTGDEMVTDQAF---EDRLKEAEREVMDLLREA 1089
            C+      V D   + Q LE     L  TG     + +F   +++L   +  V      A
Sbjct: 1193 CFGDWDRVVQDLAARTQRLEQRAQELQQTGVLGAFESSFWHMQEKLGIVQGIVGARNTSA 1252

Query: 1090 QDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGNLAEQARAHVENTERLIEIAS 1149
                 + +   + L+R     +  +++L+     +++    A  A + +E     + +  
Sbjct: 1253 ASTAQLVE-ATEELRREIGEATEHLTQLEADLTDVQDENFNANHALSGLERDRLALNLTL 1311

Query: 1150 RELEK--------------AKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEAD 1195
            R+L++                +  A+    + E   + + + + +  +   + RH+ EA 
Sbjct: 1312 RQLDQHLDLLKHSNFLGAYDSIRHAHSQSAEAERRANTSALAVPSPVSNSASARHRTEA- 1370

Query: 1196 DIVRVAKTANDTSTEAYNLLLRTLAGENQT--AFEIEEL--------------------N 1233
             ++   K   ++   A    L  L+    T    +I EL                     
Sbjct: 1371 -LMDAQKEDFNSKHMANQRALGKLSAHTHTLSLTDINELVCGAPGDAPCATSPCGGAGCR 1429

Query: 1234 RKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLSPLDSETLE--NEANNIKM 1291
             +  Q +         AA       RA     E+  ++A+   + S   E   +A+  + 
Sbjct: 1430 DEDGQPRCGGLSCNGAAATADLALGRARHTQAELQRALAEGGSILSRVAETRRQASEAQQ 1489

Query: 1292 EAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQQTADQLLAR---------A 1342
             A+      +      E   ++++     VK+ L +   +  + + +  R         A
Sbjct: 1490 RAQAALDKANASRGQVEQANQELQELIQSVKDFLNQEGADPDSIEMVATRVLELSIPASA 1549

Query: 1343 DAAKALAEEAAKKGRDTLQEANDIL----NNLKDFDRRVNDNKTA---AEEALRKIPAIN 1395
            +  + LA   A++ R +L + + IL     +++  ++ + D + A   AE+  +K   + 
Sbjct: 1550 EQIQHLAGAIAERVR-SLADVDAILARTVGDVRRAEQLLQDARRARSWAEDEKQKAETVQ 1608

Query: 1396 QTITEANEKTREAQQALGSAAADATEAKNKAHEA-ERIASAVQKNATSTKAEAER---TF 1451
              + EA      AQ A+  A AD  + +   ++  ER+A A  + A S+  E  R     
Sbjct: 1609 AALEEAQRAQGIAQGAIRGAVADTRDTEQTLYQVQERMAGA--ERALSSAGERARQLDAL 1666

Query: 1452 AEVTDLDNEVNNMLK------------QLQEAEKELKRKQDDADQDM-MMAGMASQAAQE 1498
             E   L    N++              + QEAE+ L+    D  Q +  +A   +Q    
Sbjct: 1667 LEALKLKRAGNSLAASTAEETAGSAQGRAQEAEQLLRGPLGDQYQTVKALAERKAQGVLA 1726

Query: 1499 AEINARKAKNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTL--NKAKDEMKVSDLDR 1556
            A+  A + ++    LL    D L+           +L E+EGT   N+   E K + LD 
Sbjct: 1727 AQARAEQLRDEARDLLQAAQDKLQ-----------RLQELEGTYEENERALESKAAQLDG 1775

Query: 1557 KVSDLENEAKKQEAAIMDYN 1576
              + + +  +     +  YN
Sbjct: 1776 LEARMRSVLQAINLQVQIYN 1795



 Score =  267 bits (683), Expect = 5e-71
 Identities = 179/539 (33%), Positives = 256/539 (47%), Gaps = 73/539 (13%)

Query: 12  RPRGRLWPV-----LAVLAAAAAAGCAQAAMDECTDEGGRPQRCMPE----FVNAAFNVT 62
           R RGR  P+     L +L +  AA  AQA   +    G     C P      V  A  +T
Sbjct: 6   RERGRGQPLPWELRLGLLLSVLAATLAQAPAPDVP--GCSRGSCYPATGDLLVGRADRLT 63

Query: 63  VVATNTCG-TPPEEYCVQTGVTGVTKSCHLCDAGQP-------HLQHGAAFLTDYNNQAD 114
             A++TCG   P+ YC+ + +    K C LCD+ +P       H       +T +  Q  
Sbjct: 64  --ASSTCGLNGPQPYCIVSHLQD-EKKCFLCDSRRPFSARDNPHSHRIQNVVTSFAPQRR 120

Query: 115 TTWWQSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIP 174
             WWQS+  +  V       + L L   F  T++ + F T RP +  + +       W  
Sbjct: 121 AAWWQSENGIPAV------TIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGRTWHV 174

Query: 175 YQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGR---PSA 231
           Y+Y+S  C   +        R   D    +C   +S+I P T G V +  L+     P  
Sbjct: 175 YRYFSYDCGADFPGVPLAPPRHWDD---VVCESRYSEIEPSTEGEVIYRVLDPAIPIPDP 231

Query: 232 YNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPK--VLKSYYYAISDFAVGGRCKCN 289
           Y    S  +Q  +  T++RV L RL+T GD +  DP+  + + YYYA+ +  V G C C 
Sbjct: 232 Y----SSRIQNLLKITNLRVNLTRLHTLGDNLL-DPRREIREKYYYALYELVVRGNCFCY 286

Query: 290 GHASECMKN-----EFDKLV---CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLP 341
           GHASEC          + +V   C CKHNT G++CE+C  F+ D PWR A    +  C  
Sbjct: 287 GHASECAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSHACRK 346

Query: 342 CDCNGRSQECYFDPELYRSTGH--GGHCTNCQDNTDGAHCERCRENFFR-----LGNNEA 394
           C+C+G +  C+FD  +Y ++G+  GG C  CQ NT G HCE CR  F+R     L +   
Sbjct: 347 CECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAV 406

Query: 395 CSSCHCSPVGSL-STQCDSY---------GRCSCKPGVMGDKCDRCQPGFHSLT---EAG 441
           C SC C P+GS    +CDS+         G+C CK  V+G +C +C+ GF  L+     G
Sbjct: 407 CRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLG 466

Query: 442 CRPCSCDPSGSI---DECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFC 497
           CR C C+  G++     C+  +G C CK  V G  C+RC PG + L S +  GC PC C
Sbjct: 467 CRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPGHWGL-SHDLLGCRPCDC 524



 Score =  180 bits (457), Expect = 9e-45
 Identities = 118/390 (30%), Positives = 157/390 (40%), Gaps = 96/390 (24%)

Query: 718  YSPCVLCACNGH---SETCDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCP 774
            Y+  + C CN     S  C+P  G C C+    G  C+ C+ GYYG    G    CQ C 
Sbjct: 777  YNGALPCQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDLCAPGYYGFGPTG----CQACQ 832

Query: 775  CPGGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNI 834
            C    + + + +     C  C TG  G RC+ C  G +G P         CR C C+ + 
Sbjct: 833  CSHEGALSSLCEKTSGQCL-CRTGAFGLRCDRCQRGQWGFP--------SCRPCVCNGHA 883

Query: 835  DPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNC-------N 887
            D      CN  TG CL C  +T G +C+RC  GF G+P  P    +C+ C C        
Sbjct: 884  D-----ECNTHTGACLGCRDHTGGEHCERCIAGFHGDPRLPY-GGQCRPCPCPEGPGSQR 937

Query: 888  LYGT------MKQQSSCNPVTGQ-------------------------CEC--------- 907
             + T        QQ  C+   G                          CEC         
Sbjct: 938  HFATSCHQDEYSQQIVCHCRAGYTGLRCEACAPGHFGDPSRPGGRCQLCECSGNIDPMDP 997

Query: 908  -------------LPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQ-------- 946
                         L H  G  C  C PGF+   + Q C RC C+ LG+   Q        
Sbjct: 998  DACDPHTGQCLRCLHHTEGPHCAHCKPGFHGQAARQSCHRCTCNLLGTNPQQCPSPDQCH 1057

Query: 947  CDIRTGQCECQPGITGQHCERCEVNHFGF-GPEGCKPCDCHPEGSLSLQCKD-DGRCECR 1004
            CD  +GQC C P + G  C+RC  N +      GC+PC CHP  +    C +  G+C CR
Sbjct: 1058 CDPSSGQCPCLPNVQGPSCDRCAPNFWNLTSGHGCQPCACHPSRARGPTCNEFTGQCHCR 1117

Query: 1005 EGFVGNRCDQCEENYFYNRSWPGCQECPAC 1034
             GF G  C +C+E ++ +   PG Q C AC
Sbjct: 1118 AGFGGRTCSECQELHWGD---PGLQ-CHAC 1143



 Score =  163 bits (412), Expect = 1e-39
 Identities = 94/282 (33%), Positives = 133/282 (47%), Gaps = 36/282 (12%)

Query: 724 CACNGHSETCDPETGV-----------CNCRDNTAGPHCEKCSDGY----YGDSTAGTSS 768
           C C GH+  C P  G            C C+ NT G +CE+C D Y    +  +  G S 
Sbjct: 283 CFCYGHASECAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSH 342

Query: 769 DCQPCPCPGGS-SC----AVVPKTKEV---VCTNCPTGTTGKRCELCDDGYFGDPLGRNG 820
            C+ C C G + SC    AV   +  V   VC  C   T G+ CELC   ++ DP     
Sbjct: 343 ACRKCECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLR 402

Query: 821 PVRLCRLCQCSDNIDPNAVGNCNR--------LTGECLKCIYNTAGFYCDRCKDGFFGNP 872
              +CR C C D +     G C+         ++G+C +C  +  G  C +C+DGFFG  
Sbjct: 403 DPAVCRSCDC-DPMGSQDGGRCDSHDDPALGLVSGQC-RCKEHVVGTRCQQCRDGFFGLS 460

Query: 873 LAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSG-QG 931
           ++      C+ C CN  GT+   + C+P +G C C   VTG+ C  C PG + L     G
Sbjct: 461 ISDRLG--CRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPGHWGLSHDLLG 518

Query: 932 CERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHF 973
           C  CDC   G+ + QCD  TGQC C+  + G+ CE+ +  +F
Sbjct: 519 CRPCDCDVGGALDPQCDEGTGQCHCRQHMVGRRCEQVQPGYF 560



 Score =  157 bits (397), Expect = 8e-38
 Identities = 97/280 (34%), Positives = 138/280 (49%), Gaps = 30/280 (10%)

Query: 765  GTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPL--GRNGPV 822
            G +S+C P P     +  +V       C  C   T G  CE C D Y   P     +G  
Sbjct: 287  GHASECAPAPGAPAHAEGMV----HGACI-CKHNTRGLNCEQCQDFYRDLPWRPAEDGHS 341

Query: 823  RLCRLCQC-----SDNIDPNA-VGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAP- 875
              CR C+C     S + D    + + N   G C  C +NTAG +C+ C+  F+ +P    
Sbjct: 342  HACRKCECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDL 401

Query: 876  -NPADKCKACNCNLYGTM---KQQSSCNP----VTGQCECLPHVTGQDCGACDPGFYNLQ 927
             +PA  C++C+C+  G+    +  S  +P    V+GQC C  HV G  C  C  GF+ L 
Sbjct: 402  RDPA-VCRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCRDGFFGLS 460

Query: 928  SGQ--GCERCDCHALGSTNGQ--CDIRTGQCECQPGITGQHCERCEVNHFGFGPE--GCK 981
                 GC RC C+A G+  G   CD  +G C C+  +TG+ C+RC   H+G   +  GC+
Sbjct: 461  ISDRLGCRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPGHWGLSHDLLGCR 520

Query: 982  PCDCHPEGSLSLQCKD-DGRCECREGFVGNRCDQCEENYF 1020
            PCDC   G+L  QC +  G+C CR+  VG RC+Q +  YF
Sbjct: 521  PCDCDVGGALDPQCDEGTGQCHCRQHMVGRRCEQVQPGYF 560



 Score =  123 bits (309), Expect = 1e-27
 Identities = 66/199 (33%), Positives = 94/199 (47%), Gaps = 21/199 (10%)

Query: 292  ASECMKNEFDK-LVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQE 350
            A+ C ++E+ + +VC+C+    G+ CE C P     P R         C  C+C+G    
Sbjct: 940  ATSCHQDEYSQQIVCHCRAGYTGLRCEACAPGHFGDPSR-----PGGRCQLCECSGNIDP 994

Query: 351  CYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQC 410
               DP+      H G C  C  +T+G HC  C+  F      ++C  C C+ +G+   QC
Sbjct: 995  --MDPDA--CDPHTGQCLRCLHHTEGPHCAHCKPGFHGQAARQSCHRCTCNLLGTNPQQC 1050

Query: 411  ---------DSYGRCSCKPGVMGDKCDRCQPGFHSLTEA-GCRPCSCDPSGSI-DECNIE 459
                      S G+C C P V G  CDRC P F +LT   GC+PC+C PS +    CN  
Sbjct: 1051 PSPDQCHCDPSSGQCPCLPNVQGPSCDRCAPNFWNLTSGHGCQPCACHPSRARGPTCNEF 1110

Query: 460  TGRCVCKDNVEGFNCERCK 478
            TG+C C+    G  C  C+
Sbjct: 1111 TGQCHCRAGFGGRTCSECQ 1129



 Score =  116 bits (291), Expect = 2e-25
 Identities = 85/280 (30%), Positives = 112/280 (40%), Gaps = 46/280 (16%)

Query: 678 PGPGVPATWVE----SCTCPVGYGGQFCEMCLSGYRR---ETPNLGPYSPCVLCACNGHS 730
           P PG PA        +C C     G  CE C   YR         G    C  C C+GH+
Sbjct: 294 PAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSHACRKCECHGHT 353

Query: 731 ETC-----------DPETGVCN-CRDNTAGPHCEKCSDGYYGDSTAG-------TSSDCQ 771
            +C           +   GVC+ C+ NTAG HCE C   +Y D T          S DC 
Sbjct: 354 HSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAVCRSCDCD 413

Query: 772 PCPCPGGSSCAVVPKTKEVVCT---NCPTGTTGKRCELCDDGYFG----DPLGRNGPVRL 824
           P     G  C         + +    C     G RC+ C DG+FG    D LG       
Sbjct: 414 PMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLG------- 466

Query: 825 CRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKAC 884
           CR CQC+          C+  +G C  C     G  CDRC  G +G     +    C+ C
Sbjct: 467 CRRCQCNARGTVPGSTPCDPNSGSCY-CKRLVTGRGCDRCLPGHWG---LSHDLLGCRPC 522

Query: 885 NCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFY 924
           +C++ G +  Q  C+  TGQC C  H+ G+ C    PG++
Sbjct: 523 DCDVGGALDPQ--CDEGTGQCHCRQHMVGRRCEQVQPGYF 560



 Score =  113 bits (282), Expect = 2e-24
 Identities = 74/233 (31%), Positives = 103/233 (44%), Gaps = 33/233 (14%)

Query: 286  CKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDC- 344
            C CNGHA EC  N        C+ +T G  CE+C+  F+  P          +C PC C 
Sbjct: 877  CVCNGHADEC--NTHTGACLGCRDHTGGEHCERCIAGFHGDP----RLPYGGQCRPCPCP 930

Query: 345  NGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFF----RLGNNEACSSCHC 400
             G   + +F    ++         +C+    G  CE C    F    R G    C  C C
Sbjct: 931  EGPGSQRHFATSCHQDEYSQQIVCHCRAGYTGLRCEACAPGHFGDPSRPGGR--CQLCEC 988

Query: 401  SPVGSLSTQ----CDSY-GRC-SCKPGVMGDKCDRCQPGFHS-LTEAGCRPCSCDPSG-- 451
            S  G++       CD + G+C  C     G  C  C+PGFH       C  C+C+  G  
Sbjct: 989  S--GNIDPMDPDACDPHTGQCLRCLHHTEGPHCAHCKPGFHGQAARQSCHRCTCNLLGTN 1046

Query: 452  -----SIDECNIE--TGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFC 497
                 S D+C+ +  +G+C C  NV+G +C+RC P F+NL S +  GC PC C
Sbjct: 1047 PQQCPSPDQCHCDPSSGQCPCLPNVQGPSCDRCAPNFWNLTSGH--GCQPCAC 1097



 Score =  107 bits (266), Expect = 1e-22
 Identities = 44/114 (38%), Positives = 65/114 (57%), Gaps = 7/114 (6%)

Query: 398 CHCSPVGSLSTQCDSYG-RCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDE- 455
           C C+P GSLS++C+ +G +C CKPGV+G +CD C PG++     GC+ C C   G++   
Sbjct: 783 CQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDLCAPGYYGFGPTGCQACQCSHEGALSSL 842

Query: 456 CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVG 509
           C   +G+C+C+    G  C+RC+ G +   S     C PC C GH+  C    G
Sbjct: 843 CEKTSGQCLCRTGAFGLRCDRCQRGQWGFPS-----CRPCVCNGHADECNTHTG 891



 Score =  102 bits (254), Expect = 3e-21
 Identities = 46/117 (39%), Positives = 66/117 (56%), Gaps = 6/117 (5%)

Query: 918  ACDPGFYNLQS--GQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGF 975
            AC P   +L +    G   C C+  GS + +C+   GQC C+PG+ G+ C+ C   ++GF
Sbjct: 764  ACAPLLISLSTLIYNGALPCQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDLCAPGYYGF 823

Query: 976  GPEGCKPCDCHPEGSLSLQC-KDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQEC 1031
            GP GC+ C C  EG+LS  C K  G+C CR G  G RCD+C+   +    +P C+ C
Sbjct: 824  GPTGCQACQCSHEGALSSLCEKTSGQCLCRTGAFGLRCDRCQRGQW---GFPSCRPC 877



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 64/224 (28%), Positives = 82/224 (36%), Gaps = 76/224 (33%)

Query: 340 LPCDCNGR---SQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACS 396
           LPC CN +   S EC           HGG C  C+    G  C+ C   ++  G    C 
Sbjct: 781 LPCQCNPQGSLSSEC---------NPHGGQCL-CKPGVVGRRCDLCAPGYYGFGPT-GCQ 829

Query: 397 SCHCSPVGSLSTQCD-SYGRCSCKPGVMGDKCDRCQ------------------------ 431
           +C CS  G+LS+ C+ + G+C C+ G  G +CDRCQ                        
Sbjct: 830 ACQCSHEGALSSLCEKTSGQCLCRTGAFGLRCDRCQRGQWGFPSCRPCVCNGHADECNTH 889

Query: 432 --------------------PGFHS---LTEAG-CRPCSCDPSGSIDECNIETGR----- 462
                                GFH    L   G CRPC C P G   + +  T       
Sbjct: 890 TGACLGCRDHTGGEHCERCIAGFHGDPRLPYGGQCRPCPC-PEGPGSQRHFATSCHQDEY 948

Query: 463 -----CVCKDNVEGFNCERCKPGFFNLESSNPRG-CTPCFCFGH 500
                C C+    G  CE C PG F  + S P G C  C C G+
Sbjct: 949 SQQIVCHCRAGYTGLRCEACAPGHFG-DPSRPGGRCQLCECSGN 991



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 55/229 (24%), Positives = 78/229 (34%), Gaps = 84/229 (36%)

Query: 283  GGRCK---------------CNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRP 327
            GGRC+               C+ H  +C++         C H+T G  C  C P F+ + 
Sbjct: 980  GGRCQLCECSGNIDPMDPDACDPHTGQCLR---------CLHHTEGPHCAHCKPGFHGQA 1030

Query: 328  WRRATAESASECLPCDCN--GRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCREN 385
             R++       C  C CN  G + +    P+        G C  C  N  G  C+RC  N
Sbjct: 1031 ARQS-------CHRCTCNLLGTNPQQCPSPDQCHCDPSSGQCP-CLPNVQGPSCDRCAPN 1082

Query: 386  FFRLGNNEACSSCHCSPVGSLSTQCDSY-------------------------------- 413
            F+ L +   C  C C P  +    C+ +                                
Sbjct: 1083 FWNLTSGHGCQPCACHPSRARGPTCNEFTGQCHCRAGFGGRTCSECQELHWGDPGLQCHA 1142

Query: 414  -----------------GRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPC 445
                             G CSC+PGV G +CD+C  GF  +  A C PC
Sbjct: 1143 CDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCDQCARGFSGIFPA-CHPC 1190



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 33/89 (37%), Positives = 43/89 (48%), Gaps = 10/89 (11%)

Query: 428 DRCQPGFHSLTEA---GCRPCSCDPSGSI-DECNIETGRCVCKDNVEGFNCERCKPGFFN 483
           + C P   SL+     G  PC C+P GS+  ECN   G+C+CK  V G  C+ C PG++ 
Sbjct: 763 EACAPLLISLSTLIYNGALPCQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDLCAPGYYG 822

Query: 484 LESSNPRGCTPCFCFGH---SSVCTNAVG 509
                P GC  C C      SS+C    G
Sbjct: 823 F---GPTGCQACQCSHEGALSSLCEKTSG 848



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 20/65 (30%), Positives = 29/65 (44%), Gaps = 5/65 (7%)

Query: 445 CSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPGFFNL-----ESSNPRGCTPCFCFG 499
           C+  P        +  G C+CK N  G NCE+C+  + +L     E  +   C  C C G
Sbjct: 292 CAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSHACRKCECHG 351

Query: 500 HSSVC 504
           H+  C
Sbjct: 352 HTHSC 356



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 33/118 (27%), Positives = 48/118 (40%), Gaps = 21/118 (17%)

Query: 276 AISDFAVGGRCKCNGH-----ASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRR 330
           +ISD     RC+CN       ++ C  N      C CK    G  C++CLP      W  
Sbjct: 460 SISDRLGCRRCQCNARGTVPGSTPCDPNSGS---CYCKRLVTGRGCDRCLPGH----W-- 510

Query: 331 ATAESASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFR 388
             +     C PCDC+        DP+    TG      +C+ +  G  CE+ +  +FR
Sbjct: 511 GLSHDLLGCRPCDCDVGGA---LDPQCDEGTGQ----CHCRQHMVGRRCEQVQPGYFR 561


>gi|38045910 laminin alpha 3 subunit isoform 1 [Homo sapiens]
          Length = 3333

 Score =  285 bits (728), Expect = 3e-76
 Identities = 179/566 (31%), Positives = 257/566 (45%), Gaps = 78/566 (13%)

Query: 8   APALRPRGR-LWPVLA-----VLAAAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFNV 61
           A A RPRGR L PVL      +L       C   A D     G       P + N A   
Sbjct: 2   AAAARPRGRALGPVLPPTPLLLLVLRVLPACGATARDPGAAAG---LSLHPTYFNLAEAA 58

Query: 62  TVVATNTCGT--------PPEEYCVQTGVTGVTKS--------CHLCDAGQPHLQHGAAF 105
            + AT TCG          PE YC   G      S        C  C++  P   H    
Sbjct: 59  RIWATATCGERGPGEGRPQPELYCKLVGGPTAPGSGHTIQGQFCDYCNSEDPRKAHPVTN 118

Query: 106 LTDYNNQADTTWWQSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTS-RPESFAIYK 164
             D + +    WWQS  + +G QY + +NLTL LG+ F + Y+ +KF  S RP+ + + +
Sbjct: 119 AIDGSER----WWQSPPLSSGTQY-NRVNLTLDLGQLFHVAYILIKFANSPRPDLWVLER 173

Query: 165 RTREDGPWIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFST 224
                  + P+QY++ S  +   +  R        +   LC  E+S I PL  G V  S 
Sbjct: 174 SVDFGSTYSPWQYFAHSKVDCLKEFGREANMAVTRDDDVLCVTEYSRIVPLENGEVVVSL 233

Query: 225 LEGRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFN----DPKVLKSYYYAISDF 280
           + GRP A NF  S  L+E+  AT+IR+   R NT    + +    DP V + YYY+I D 
Sbjct: 234 INGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLGHLISKAQRDPTVTRRYYYSIKDI 293

Query: 281 AVGGRCKCNGHASECMKNEFDKLV-CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASEC 339
           ++GG+C CNGHA  C  N  +KL  C C+H+T G  C++C   +N R WR A  E + EC
Sbjct: 294 SIGGQCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHEC 353

Query: 340 LPCDCNGRSQECYFDPELYRSTGH---------GGHCTNCQDNTDGAHCERCRENFFR-- 388
             C+C+G +  CY+DP++ R             GG C NCQ NT G +CE+C + ++R  
Sbjct: 354 EACNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPY 413

Query: 389 ---LGNNEACSSCHCSPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSL-------- 437
              +   + C  C C P  +   +  S GRC CKP   GD C++C  G+++         
Sbjct: 414 GVPVDAPDGCIPCSCDPEHADGCEQGS-GRCHCKPNFHGDNCEKCAIGYYNFPFCLRIPI 472

Query: 438 -----------TEAGCRPCSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPGFFNLES 486
                           + C C+  G + E     GRC+C+  VEG  C+ C+ GF++   
Sbjct: 473 FPVSTPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFPI 532

Query: 487 SNPRGCTPCFCFGHSSV---CTNAVG 509
                C  C+C    S    C++  G
Sbjct: 533 -----CQACWCSALGSYQMPCSSVTG 553



 Score =  280 bits (717), Expect = 6e-75
 Identities = 193/605 (31%), Positives = 276/605 (45%), Gaps = 90/605 (14%)

Query: 305  CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHG 364
            C C+ N  G  C +C       P           C PC C  R  E              
Sbjct: 1285 CPCQPNVIGRQCTRCATGHYGFP----------RCKPCSCGRRLCE-----------EMT 1323

Query: 365  GHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLST---QCD-SYGRCSCKP 420
            G C  C   T    CE C  + F       C  C+CS  G++     +CD   G+C CKP
Sbjct: 1324 GQC-RCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEAAMPECDRDSGQCRCKP 1382

Query: 421  GVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDE-CNIETGRCVCKDNVEGFNCERCKP 479
             + G +CDRC  GF+   E  C PC+C+  G+    C+  TG C+CK+NVEG  C  C+ 
Sbjct: 1383 RITGRQCDRCASGFYRFPE--CVPCNCNRDGTEPGVCDPGTGACLCKENVEGTECNVCRE 1440

Query: 480  GFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAEQRDGSEASLE 539
            G F+L+ +N +GCT CFCFG ++ C     +S +   + F +D  GW  E  D  +  + 
Sbjct: 1441 GSFHLDPANLKGCTSCFCFGVNNQC-----HSSHKRRTKF-VDMLGWHLETADRVDIPVS 1494

Query: 540  W----SSERQDIAVISDSYFPRYFIAPAKFLGKQVLSYGQNLSFSFRVDRRDTRLSAEDL 595
            +    +S   D+  +  +     ++AP  +LG +V SYG  L++      +   L  + +
Sbjct: 1495 FNPGSNSMVADLQELPATIHSASWVAPTSYLGDKVSSYGGYLTY----QAKSFGLPGDMV 1550

Query: 596  VLEGAGLRVSVPLIAQGNS-YPSETTVKYVFRLHEATDY---------PWRPALTPFEFQ 645
            +LE    +  V L  Q  S    ET      RLH    +           R  ++  E  
Sbjct: 1551 LLE---KKPDVQLTGQHMSIIYEETNTPRPDRLHHGRVHVVEGNFRHASSRAPVSREELM 1607

Query: 646  KLLNNLTSIKIRGTY-SERSAGYLDDVTLASAR-PGPGVPATWVESCTCPVGYGGQFCEM 703
             +L+ L  ++I+G Y +E     L +V L  A   G G  A  VE C CP  Y G  C+ 
Sbjct: 1608 TVLSRLADVRIQGLYFTETQRLTLSEVGLEEASDTGSGRIALAVEICACPPAYAGDSCQG 1667

Query: 704  CLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVC-NCRDNTAGPHCEKCSDGYYGDS 762
            C  GY R+   L     CV C CNGHS  C   +G+C NC+ NTAG HCE+C +GYYG++
Sbjct: 1668 CSPGYYRDHKGLYT-GRCVPCNCNGHSNQCQDGSGICVNCQHNTAGEHCERCQEGYYGNA 1726

Query: 763  TAGTSSDCQPCPCPGGSSCAV--VPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNG 820
              G+   C+ CPCP  +S A   V    +V C +C  G TG +CE C  GYFG+P    G
Sbjct: 1727 VHGS---CRACPCPHTNSFATGCVVNGGDVRC-SCKAGYTGTQCERCAPGYFGNPQKFGG 1782

Query: 821  PVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADK 880
                C+ C C+ N     +G+C+ LTG+C+                     P   +PA++
Sbjct: 1783 S---CQPCSCNSN---GQLGSCHPLTGDCIN------------------QEPKDSSPAEE 1818

Query: 881  CKACN 885
            C  C+
Sbjct: 1819 CDDCD 1823



 Score =  175 bits (443), Expect = 4e-43
 Identities = 121/384 (31%), Positives = 165/384 (42%), Gaps = 60/384 (15%)

Query: 690  CTCPVGYGGQFCEMCLSGY--RRETPNLGPYS-PCVLCACNGHSETC--DPET------- 737
            C C     G+ C+ C +GY  RR  P     S  C  C C+GH+  C  DP+        
Sbjct: 319  CECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHGHASNCYYDPDVERQQASL 378

Query: 738  ---------GVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSSD--CQPCPCPGGSSCAVVP 785
                     GVC NC+ NTAG +CE+C+ GYY        +   C PC C    +     
Sbjct: 379  NTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAPDGCIPCSCDPEHADGCEQ 438

Query: 786  KTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVG-NCNR 844
             +      +C     G  CE C  GY+  P     P+         D +  +  G +CN 
Sbjct: 439  GSGRC---HCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNL 495

Query: 845  ---------LTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQ 895
                       G CL C     G  CD C+ GF+  P+       C+AC C+  G+   Q
Sbjct: 496  EGVLPEICDAHGRCL-CRPGVEGPRCDTCRSGFYSFPI-------CQACWCSALGSY--Q 545

Query: 896  SSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCE 955
              C+ VTGQCEC P VTGQ C  C  G Y+    QG     C   G+ N       G C+
Sbjct: 546  MPCSSVTGQCECRPGVTGQRCDRCLSGAYDFPHCQGSSSA-CDPAGTINSNL----GYCQ 600

Query: 956  CQPGITGQHCERCEVNHFGF---GPEGCKPCDCHPEGSLSL--QCKD-DGRCECREGFVG 1009
            C+  + G  C RC++ ++      P GC  C CH  G++S   +C+  DG C C+    G
Sbjct: 601  CKLHVEGPTCSRCKLLYWNLDKENPSGCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGG 660

Query: 1010 NRCDQCEENYF--YNRSWPGCQEC 1031
            + CD CE+ YF     ++ GCQ C
Sbjct: 661  DSCDTCEDGYFALEKSNYFGCQGC 684



 Score =  138 bits (347), Expect = 5e-32
 Identities = 173/759 (22%), Positives = 312/759 (41%), Gaps = 102/759 (13%)

Query: 905  CECLPHVTGQDCGACDPGFYNLQSGQGCERC-DCHALGSTNGQCDIRTGQC-ECQPGITG 962
            C C P   G  C  C PG+Y    G    RC  C+  G +N QC   +G C  CQ    G
Sbjct: 1654 CACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSN-QCQDGSGICVNCQHNTAG 1712

Query: 963  QHCERCEVNHFGFGPEG-CKPCDCHPEGSLSLQCKDDG---RCECREGFVGNRCDQCEEN 1018
            +HCERC+  ++G    G C+ C C    S +  C  +G   RC C+ G+ G +C++C   
Sbjct: 1713 EHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPG 1772

Query: 1019 YFYNRSWPG--CQECP--------ACYRLVKD------KVADHRVKLQELESLIANLGTG 1062
            YF N    G  CQ C         +C+ L  D      K +    +  + +S +  L   
Sbjct: 1773 YFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDCDSCVMTLLND 1832

Query: 1063 DEMVTDQAFEDRLKEAEREVMD----LLREAQDVKDVDQNLMDRLQRVNNTLSSQISRLQ 1118
               + +Q    RL +++ + +     LL + + ++   ++L ++L    + +S+  S+++
Sbjct: 1833 LATMGEQL---RLVKSQLQGLSASAGLLEQMRHMETQAKDLRNQLLNYRSAISNHGSKIE 1889

Query: 1119 NIRNTI----EETGNLAEQARAHVENTERLIEIASRELEKAK---------VAAANVSVT 1165
             +   +    +E   L E+A+ +    + L    +R  + AK         +   ++ + 
Sbjct: 1890 GLERELTDLNQEFETLQEKAQVNSRKAQTLNNNVNRATQSAKELDVKIKNVIRNVHILLK 1949

Query: 1166 QPEST-GDPNNMTL------LAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLL--- 1215
            Q   T G+ NN+         AE  R + E   +     +R A+     S    N +   
Sbjct: 1950 QISGTDGEGNNVPSGDFSREWAEAQRMMRELRNRNFGKHLREAEADKRESQLLLNRIRTW 2009

Query: 1216 LRTLAGENQ-TAFEIEELNRKYE-QAKNISQDLE------KQAARVHEEAKRAGDKAVEI 1267
             +T  GEN   A  I +   +YE +  ++   L+      KQA  +++E +RA      I
Sbjct: 2010 QKTHQGENNGLANSIRDSLNEYEAKLSDLRARLQEAAAQAKQANGLNQENERA---LGAI 2066

Query: 1268 YASVAQLSPLDSETLE--NEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLL 1325
               V +++ L S+  +    A++  ++     QL+++  K+YE L   +     E+ + +
Sbjct: 2067 QRQVKEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEKLAASLNEARQELSDKV 2126

Query: 1326 EKGKTEQQTADQLLARADAAKALAEEAAKKGRDTLQEANDILNNLK------DFDRRVND 1379
             +           L+R+    +L EEA K  R +LQE    L  +K      +  R   D
Sbjct: 2127 RE-----------LSRSAGKTSLVEEAEKHAR-SLQELAKQLEEIKRNASGDELVRCAVD 2174

Query: 1380 NKTAAEEALRKIPAINQTITEANEKTREAQQALGSAAADATEAKNKAHEAERIASAVQKN 1439
              TA E  L  I A             +A     SA+  A +   K  +  R A  +  N
Sbjct: 2175 AATAYENILNAIKA-----------AEDAANRAASASESALQTVIK-EDLPRKAKTLSSN 2222

Query: 1440 ATSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDADQDMMMAGMASQAAQEA 1499
            +     EA+ T  +   L  EV+  L  LQ+    +  +++  D ++          Q  
Sbjct: 2223 SDKLLNEAKMTQKK---LKQEVSPALNNLQQTLNIVTVQKEVIDTNLTTLRDGLHGIQRG 2279

Query: 1500 EINA--RKAKNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDEMKVSDLDRK 1557
            +I+A    AK+ V     I +++L+ L  + T D+ ++ +  G       +  ++D D  
Sbjct: 2280 DIDAMISSAKSMVRKANDITDEVLDGLNPIQT-DVERIKDTYGRTQNEDFKKALTDADNS 2338

Query: 1558 VSDLENEAKKQEAAIMDYNRDIEEIMKDIRNLEDIRKTL 1596
            V+ L N+       I   N+ +  +     N++ IR+ +
Sbjct: 2339 VNKLTNKLPDLWRKIESINQQLLPLGNISDNMDRIRELI 2377



 Score =  136 bits (343), Expect = 1e-31
 Identities = 95/350 (27%), Positives = 143/350 (40%), Gaps = 88/350 (25%)

Query: 692 CPVGYGGQFCEMCLSGYRRE--TPNLGPYSPCVLCACNG-HSETCDPETGVCNCRDNTAG 748
           C     G  CE C  GY R    P   P   C+ C+C+  H++ C+  +G C+C+ N  G
Sbjct: 393 CQHNTAGVNCEQCAKGYYRPYGVPVDAP-DGCIPCSCDPEHADGCEQGSGRCHCKPNFHG 451

Query: 749 PHCEKCSDGYYG---------------DSTAGTSSDCQPCPCPGGSSCAVVPKTKEVV-- 791
            +CEKC+ GYY                 S    + D + C C   +   V+P+  +    
Sbjct: 452 DNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDC---NLEGVLPEICDAHGR 508

Query: 792 CTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGN----CNRLTG 847
           C  C  G  G RC+ C  G++  P+        C+ C CS      A+G+    C+ +TG
Sbjct: 509 CL-CRPGVEGPRCDTCRSGFYSFPI--------CQACWCS------ALGSYQMPCSSVTG 553

Query: 848 ECLKCIYNTAGFYCDRCKDGFF------GNPLAPNPA----------------------- 878
           +C +C     G  CDRC  G +      G+  A +PA                       
Sbjct: 554 QC-ECRPGVTGQRCDRCLSGAYDFPHCQGSSSACDPAGTINSNLGYCQCKLHVEGPTCSR 612

Query: 879 --------DK-----CKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYN 925
                   DK     C  C C+  GT+     C    G C C  HV G  C  C+ G++ 
Sbjct: 613 CKLLYWNLDKENPSGCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFA 672

Query: 926 LQSGQ--GCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHF 973
           L+     GC+ C C   G+ +  C   +G C+C+  + G+ C+R E N++
Sbjct: 673 LEKSNYFGCQGCQCDIGGALSSMCSGPSGVCQCREHVVGKVCQRPENNYY 722



 Score =  130 bits (328), Expect = 8e-30
 Identities = 82/245 (33%), Positives = 113/245 (46%), Gaps = 24/245 (9%)

Query: 265 NDPKVLKSYY--YAISDFAVGG--RCKCNG-HASECMKNEFDKLVCNCKHNTYGVDCEKC 319
           N  +  K YY  Y +   A  G   C C+  HA  C +       C+CK N +G +CEKC
Sbjct: 401 NCEQCAKGYYRPYGVPVDAPDGCIPCSCDPEHADGCEQGSGR---CHCKPNFHGDNCEKC 457

Query: 320 ------LPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDN 373
                  PF    P    +  S+ + +  D  G   +C  +  L       G C  C+  
Sbjct: 458 AIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGC--DCNLEGVLPEICDAHGRCL-CRPG 514

Query: 374 TDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSY-GRCSCKPGVMGDKCDRCQP 432
            +G  C+ CR  F+       C +C CS +GS    C S  G+C C+PGV G +CDRC  
Sbjct: 515 VEGPRCDTCRSGFYSF---PICQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCDRCLS 571

Query: 433 GFHSLTEAGCRPCSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGC 492
           G +          +CDP+G+I   N   G C CK +VEG  C RCK  ++NL+  NP GC
Sbjct: 572 GAYDFPHCQGSSSACDPAGTI---NSNLGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGC 628

Query: 493 TPCFC 497
           + C C
Sbjct: 629 SECKC 633



 Score =  124 bits (312), Expect = 6e-28
 Identities = 75/245 (30%), Positives = 113/245 (46%), Gaps = 28/245 (11%)

Query: 828  CQCSDNIDPNAVG-NCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNC 886
            C+C       A G +C+   G+C  C  N  G  C RC  G +G P       +CK C+C
Sbjct: 1266 CECHPT---GATGPHCSPEGGQC-PCQPNVIGRQCTRCATGHYGFP-------RCKPCSC 1314

Query: 887  NLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNG- 945
                    +  C  +TGQC C P      C  C+   ++     GCE C+C   G+    
Sbjct: 1315 G-------RRLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEAA 1367

Query: 946  --QCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDD-GRCE 1002
              +CD  +GQC C+P ITG+ C+RC    + F PE C PC+C+ +G+    C    G C 
Sbjct: 1368 MPECDRDSGQCRCKPRITGRQCDRCASGFYRF-PE-CVPCNCNRDGTEPGVCDPGTGACL 1425

Query: 1003 CREGFVGNRCDQCEENYFY--NRSWPGCQECPACYRLVKDKVADHRVKLQELESLIANLG 1060
            C+E   G  C+ C E  F+    +  GC  C  C+ +     + H+ + + ++ L  +L 
Sbjct: 1426 CKENVEGTECNVCREGSFHLDPANLKGCTSC-FCFGVNNQCHSSHKRRTKFVDMLGWHLE 1484

Query: 1061 TGDEM 1065
            T D +
Sbjct: 1485 TADRV 1489



 Score =  115 bits (287), Expect = 4e-25
 Identities = 74/230 (32%), Positives = 100/230 (43%), Gaps = 36/230 (15%)

Query: 724  CACNGHSET---CDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSS 780
            C C+    T   C PE G C C+ N  G  C +C+ G+YG         C+PC C G   
Sbjct: 1266 CECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYG------FPRCKPCSC-GRRL 1318

Query: 781  CAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCS-DNIDPNAV 839
            C  +          CP  T   +CE+C+   F        P+  C  C CS       A+
Sbjct: 1319 CEEMTGQ-----CRCPPRTVRPQCEVCETHSFS-----FHPMAGCEGCNCSRRGTIEAAM 1368

Query: 840  GNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCN 899
              C+R +G+C +C     G  CDRC  GF+  P       +C  CNCN  GT  +   C+
Sbjct: 1369 PECDRDSGQC-RCKPRITGRQCDRCASGFYRFP-------ECVPCNCNRDGT--EPGVCD 1418

Query: 900  PVTGQCECLPHVTGQDCGACDPGFYNLQSG--QGCERCDCHALGSTNGQC 947
            P TG C C  +V G +C  C  G ++L     +GC  C C  +   N QC
Sbjct: 1419 PGTGACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFCFGV---NNQC 1465



 Score =  109 bits (272), Expect = 2e-23
 Identities = 59/195 (30%), Positives = 85/195 (43%), Gaps = 27/195 (13%)

Query: 795  CPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIY 854
            C     G++C  C  G++G P         C+ C C   +       C  +TG+C +C  
Sbjct: 1287 CQPNVIGRQCTRCATGHYGFPR--------CKPCSCGRRL-------CEEMTGQC-RCPP 1330

Query: 855  NTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQ-QSSCNPVTGQCECLPHVTG 913
             T    C+ C+   F      +P   C+ CNC+  GT++     C+  +GQC C P +TG
Sbjct: 1331 RTVRPQCEVCETHSFSF----HPMAGCEGCNCSRRGTIEAAMPECDRDSGQCRCKPRITG 1386

Query: 914  QDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHF 973
            + C  C  GFY       C  C+C+  G+  G CD  TG C C+  + G  C  C    F
Sbjct: 1387 RQCDRCASGFYRFPE---CVPCNCNRDGTEPGVCDPGTGACLCKENVEGTECNVCREGSF 1443

Query: 974  GFGP---EGCKPCDC 985
               P   +GC  C C
Sbjct: 1444 HLDPANLKGCTSCFC 1458



 Score = 97.8 bits (242), Expect = 7e-20
 Identities = 50/154 (32%), Positives = 70/154 (45%), Gaps = 16/154 (10%)

Query: 883  ACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGS 942
            A  C  + T      C+P  GQC C P+V G+ C  C  G Y       C+ C C     
Sbjct: 1263 ALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPR---CKPCSC----- 1314

Query: 943  TNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGP-EGCKPCDCHPEGSLSL---QC-KD 997
                C+  TGQC C P      CE CE + F F P  GC+ C+C   G++     +C +D
Sbjct: 1315 GRRLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEAAMPECDRD 1374

Query: 998  DGRCECREGFVGNRCDQCEENYFYNRSWPGCQEC 1031
             G+C C+    G +CD+C   ++    +P C  C
Sbjct: 1375 SGQCRCKPRITGRQCDRCASGFY---RFPECVPC 1405



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 61/212 (28%), Positives = 94/212 (44%), Gaps = 28/212 (13%)

Query: 280 FAVGGRCKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASEC 339
           F +   C C+   S  M        C C+    G  C++CL    D P            
Sbjct: 530 FPICQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCDRCLSGAYDFP------------ 577

Query: 340 LPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLG--NNEACSS 397
               C G S  C  DP       + G+C  C+ + +G  C RC+  ++ L   N   CS 
Sbjct: 578 ---HCQGSSSAC--DPA-GTINSNLGYC-QCKLHVEGPTCSRCKLLYWNLDKENPSGCSE 630

Query: 398 CHCSPVGSLST--QC-DSYGRCSCKPGVMGDKCDRCQPGFHSLTEA---GCRPCSCDPSG 451
           C C   G++S   +C    G C CK  V GD CD C+ G+ +L ++   GC+ C CD  G
Sbjct: 631 CKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGG 690

Query: 452 SIDE-CNIETGRCVCKDNVEGFNCERCKPGFF 482
           ++   C+  +G C C+++V G  C+R +  ++
Sbjct: 691 ALSSMCSGPSGVCQCREHVVGKVCQRPENNYY 722



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 37/103 (35%), Positives = 50/103 (48%), Gaps = 8/103 (7%)

Query: 930  QGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEG 989
            +G   C+CH  G+T   C    GQC CQP + G+ C RC   H+GF    CKPC C    
Sbjct: 1261 KGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGF--PRCKPCSCGRR- 1317

Query: 990  SLSLQCKD-DGRCECREGFVGNRCDQCEENYFYNRSWPGCQEC 1031
                 C++  G+C C    V  +C+ CE + F      GC+ C
Sbjct: 1318 ----LCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGC 1356



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 45/156 (28%), Positives = 62/156 (39%), Gaps = 28/156 (17%)

Query: 286  CKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPC-DC 344
            C CNGH+++C       +  NC+HNT G  CE+C     +  +  A   S   C PC   
Sbjct: 1687 CNCNGHSNQCQDGS--GICVNCQHNTAGEHCERC----QEGYYGNAVHGSCRAC-PCPHT 1739

Query: 345  NGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNE----ACSSCHC 400
            N  +  C  +       G    C +C+    G  CERC   +F  GN +    +C  C C
Sbjct: 1740 NSFATGCVVN-------GGDVRC-SCKAGYTGTQCERCAPGYF--GNPQKFGGSCQPCSC 1789

Query: 401  SPVGSLSTQCDSYGRC------SCKPGVMGDKCDRC 430
            +  G L +     G C         P    D CD C
Sbjct: 1790 NSNGQLGSCHPLTGDCINQEPKDSSPAEECDDCDSC 1825



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 23/90 (25%), Positives = 41/90 (45%), Gaps = 4/90 (4%)

Query: 958  PGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCK-DDGRCECREGFVGNRCDQCE 1016
            P    + C+    +   F  +G  PC+CHP G+    C  + G+C C+   +G +C +C 
Sbjct: 1241 PQTASRFCKNSARSLVAFYHKGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCA 1300

Query: 1017 ENYFYNRSWPGCQECPACYRLVKDKVADHR 1046
              ++    +P C+ C    RL ++     R
Sbjct: 1301 TGHY---GFPRCKPCSCGRRLCEEMTGQCR 1327



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 24/58 (41%), Positives = 30/58 (51%), Gaps = 6/58 (10%)

Query: 441  GCRPCSCDPSGSID-ECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFC 497
            G  PC C P+G+    C+ E G+C C+ NV G  C RC  G +      PR C PC C
Sbjct: 1262 GALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGF----PR-CKPCSC 1314


>gi|189217425 laminin alpha 3 subunit isoform 3 [Homo sapiens]
          Length = 3277

 Score =  285 bits (728), Expect = 3e-76
 Identities = 179/566 (31%), Positives = 257/566 (45%), Gaps = 78/566 (13%)

Query: 8   APALRPRGR-LWPVLA-----VLAAAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFNV 61
           A A RPRGR L PVL      +L       C   A D     G       P + N A   
Sbjct: 2   AAAARPRGRALGPVLPPTPLLLLVLRVLPACGATARDPGAAAG---LSLHPTYFNLAEAA 58

Query: 62  TVVATNTCGT--------PPEEYCVQTGVTGVTKS--------CHLCDAGQPHLQHGAAF 105
            + AT TCG          PE YC   G      S        C  C++  P   H    
Sbjct: 59  RIWATATCGERGPGEGRPQPELYCKLVGGPTAPGSGHTIQGQFCDYCNSEDPRKAHPVTN 118

Query: 106 LTDYNNQADTTWWQSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTS-RPESFAIYK 164
             D + +    WWQS  + +G QY + +NLTL LG+ F + Y+ +KF  S RP+ + + +
Sbjct: 119 AIDGSER----WWQSPPLSSGTQY-NRVNLTLDLGQLFHVAYILIKFANSPRPDLWVLER 173

Query: 165 RTREDGPWIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFST 224
                  + P+QY++ S  +   +  R        +   LC  E+S I PL  G V  S 
Sbjct: 174 SVDFGSTYSPWQYFAHSKVDCLKEFGREANMAVTRDDDVLCVTEYSRIVPLENGEVVVSL 233

Query: 225 LEGRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFN----DPKVLKSYYYAISDF 280
           + GRP A NF  S  L+E+  AT+IR+   R NT    + +    DP V + YYY+I D 
Sbjct: 234 INGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLGHLISKAQRDPTVTRRYYYSIKDI 293

Query: 281 AVGGRCKCNGHASECMKNEFDKLV-CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASEC 339
           ++GG+C CNGHA  C  N  +KL  C C+H+T G  C++C   +N R WR A  E + EC
Sbjct: 294 SIGGQCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHEC 353

Query: 340 LPCDCNGRSQECYFDPELYRSTGH---------GGHCTNCQDNTDGAHCERCRENFFR-- 388
             C+C+G +  CY+DP++ R             GG C NCQ NT G +CE+C + ++R  
Sbjct: 354 EACNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPY 413

Query: 389 ---LGNNEACSSCHCSPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSL-------- 437
              +   + C  C C P  +   +  S GRC CKP   GD C++C  G+++         
Sbjct: 414 GVPVDAPDGCIPCSCDPEHADGCEQGS-GRCHCKPNFHGDNCEKCAIGYYNFPFCLRIPI 472

Query: 438 -----------TEAGCRPCSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPGFFNLES 486
                           + C C+  G + E     GRC+C+  VEG  C+ C+ GF++   
Sbjct: 473 FPVSTPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFPI 532

Query: 487 SNPRGCTPCFCFGHSSV---CTNAVG 509
                C  C+C    S    C++  G
Sbjct: 533 -----CQACWCSALGSYQMPCSSVTG 553



 Score =  280 bits (717), Expect = 6e-75
 Identities = 193/605 (31%), Positives = 276/605 (45%), Gaps = 90/605 (14%)

Query: 305  CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHG 364
            C C+ N  G  C +C       P           C PC C  R  E              
Sbjct: 1285 CPCQPNVIGRQCTRCATGHYGFP----------RCKPCSCGRRLCE-----------EMT 1323

Query: 365  GHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLST---QCD-SYGRCSCKP 420
            G C  C   T    CE C  + F       C  C+CS  G++     +CD   G+C CKP
Sbjct: 1324 GQC-RCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEAAMPECDRDSGQCRCKP 1382

Query: 421  GVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDE-CNIETGRCVCKDNVEGFNCERCKP 479
             + G +CDRC  GF+   E  C PC+C+  G+    C+  TG C+CK+NVEG  C  C+ 
Sbjct: 1383 RITGRQCDRCASGFYRFPE--CVPCNCNRDGTEPGVCDPGTGACLCKENVEGTECNVCRE 1440

Query: 480  GFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAEQRDGSEASLE 539
            G F+L+ +N +GCT CFCFG ++ C     +S +   + F +D  GW  E  D  +  + 
Sbjct: 1441 GSFHLDPANLKGCTSCFCFGVNNQC-----HSSHKRRTKF-VDMLGWHLETADRVDIPVS 1494

Query: 540  W----SSERQDIAVISDSYFPRYFIAPAKFLGKQVLSYGQNLSFSFRVDRRDTRLSAEDL 595
            +    +S   D+  +  +     ++AP  +LG +V SYG  L++      +   L  + +
Sbjct: 1495 FNPGSNSMVADLQELPATIHSASWVAPTSYLGDKVSSYGGYLTY----QAKSFGLPGDMV 1550

Query: 596  VLEGAGLRVSVPLIAQGNS-YPSETTVKYVFRLHEATDY---------PWRPALTPFEFQ 645
            +LE    +  V L  Q  S    ET      RLH    +           R  ++  E  
Sbjct: 1551 LLE---KKPDVQLTGQHMSIIYEETNTPRPDRLHHGRVHVVEGNFRHASSRAPVSREELM 1607

Query: 646  KLLNNLTSIKIRGTY-SERSAGYLDDVTLASAR-PGPGVPATWVESCTCPVGYGGQFCEM 703
             +L+ L  ++I+G Y +E     L +V L  A   G G  A  VE C CP  Y G  C+ 
Sbjct: 1608 TVLSRLADVRIQGLYFTETQRLTLSEVGLEEASDTGSGRIALAVEICACPPAYAGDSCQG 1667

Query: 704  CLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVC-NCRDNTAGPHCEKCSDGYYGDS 762
            C  GY R+   L     CV C CNGHS  C   +G+C NC+ NTAG HCE+C +GYYG++
Sbjct: 1668 CSPGYYRDHKGLYT-GRCVPCNCNGHSNQCQDGSGICVNCQHNTAGEHCERCQEGYYGNA 1726

Query: 763  TAGTSSDCQPCPCPGGSSCAV--VPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNG 820
              G+   C+ CPCP  +S A   V    +V C +C  G TG +CE C  GYFG+P    G
Sbjct: 1727 VHGS---CRACPCPHTNSFATGCVVNGGDVRC-SCKAGYTGTQCERCAPGYFGNPQKFGG 1782

Query: 821  PVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADK 880
                C+ C C+ N     +G+C+ LTG+C+                     P   +PA++
Sbjct: 1783 S---CQPCSCNSN---GQLGSCHPLTGDCIN------------------QEPKDSSPAEE 1818

Query: 881  CKACN 885
            C  C+
Sbjct: 1819 CDDCD 1823



 Score =  175 bits (443), Expect = 4e-43
 Identities = 121/384 (31%), Positives = 165/384 (42%), Gaps = 60/384 (15%)

Query: 690  CTCPVGYGGQFCEMCLSGY--RRETPNLGPYS-PCVLCACNGHSETC--DPET------- 737
            C C     G+ C+ C +GY  RR  P     S  C  C C+GH+  C  DP+        
Sbjct: 319  CECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHGHASNCYYDPDVERQQASL 378

Query: 738  ---------GVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSSD--CQPCPCPGGSSCAVVP 785
                     GVC NC+ NTAG +CE+C+ GYY        +   C PC C    +     
Sbjct: 379  NTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAPDGCIPCSCDPEHADGCEQ 438

Query: 786  KTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVG-NCNR 844
             +      +C     G  CE C  GY+  P     P+         D +  +  G +CN 
Sbjct: 439  GSGRC---HCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNL 495

Query: 845  ---------LTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQ 895
                       G CL C     G  CD C+ GF+  P+       C+AC C+  G+   Q
Sbjct: 496  EGVLPEICDAHGRCL-CRPGVEGPRCDTCRSGFYSFPI-------CQACWCSALGSY--Q 545

Query: 896  SSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCE 955
              C+ VTGQCEC P VTGQ C  C  G Y+    QG     C   G+ N       G C+
Sbjct: 546  MPCSSVTGQCECRPGVTGQRCDRCLSGAYDFPHCQGSSSA-CDPAGTINSNL----GYCQ 600

Query: 956  CQPGITGQHCERCEVNHFGF---GPEGCKPCDCHPEGSLSL--QCKD-DGRCECREGFVG 1009
            C+  + G  C RC++ ++      P GC  C CH  G++S   +C+  DG C C+    G
Sbjct: 601  CKLHVEGPTCSRCKLLYWNLDKENPSGCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGG 660

Query: 1010 NRCDQCEENYF--YNRSWPGCQEC 1031
            + CD CE+ YF     ++ GCQ C
Sbjct: 661  DSCDTCEDGYFALEKSNYFGCQGC 684



 Score =  136 bits (343), Expect = 1e-31
 Identities = 95/350 (27%), Positives = 143/350 (40%), Gaps = 88/350 (25%)

Query: 692 CPVGYGGQFCEMCLSGYRRE--TPNLGPYSPCVLCACNG-HSETCDPETGVCNCRDNTAG 748
           C     G  CE C  GY R    P   P   C+ C+C+  H++ C+  +G C+C+ N  G
Sbjct: 393 CQHNTAGVNCEQCAKGYYRPYGVPVDAP-DGCIPCSCDPEHADGCEQGSGRCHCKPNFHG 451

Query: 749 PHCEKCSDGYYG---------------DSTAGTSSDCQPCPCPGGSSCAVVPKTKEVV-- 791
            +CEKC+ GYY                 S    + D + C C   +   V+P+  +    
Sbjct: 452 DNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDC---NLEGVLPEICDAHGR 508

Query: 792 CTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGN----CNRLTG 847
           C  C  G  G RC+ C  G++  P+        C+ C CS      A+G+    C+ +TG
Sbjct: 509 CL-CRPGVEGPRCDTCRSGFYSFPI--------CQACWCS------ALGSYQMPCSSVTG 553

Query: 848 ECLKCIYNTAGFYCDRCKDGFF------GNPLAPNPA----------------------- 878
           +C +C     G  CDRC  G +      G+  A +PA                       
Sbjct: 554 QC-ECRPGVTGQRCDRCLSGAYDFPHCQGSSSACDPAGTINSNLGYCQCKLHVEGPTCSR 612

Query: 879 --------DK-----CKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYN 925
                   DK     C  C C+  GT+     C    G C C  HV G  C  C+ G++ 
Sbjct: 613 CKLLYWNLDKENPSGCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFA 672

Query: 926 LQSGQ--GCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHF 973
           L+     GC+ C C   G+ +  C   +G C+C+  + G+ C+R E N++
Sbjct: 673 LEKSNYFGCQGCQCDIGGALSSMCSGPSGVCQCREHVVGKVCQRPENNYY 722



 Score =  136 bits (343), Expect = 1e-31
 Identities = 160/726 (22%), Positives = 293/726 (40%), Gaps = 92/726 (12%)

Query: 905  CECLPHVTGQDCGACDPGFYNLQSGQGCERC-DCHALGSTNGQCDIRTGQC-ECQPGITG 962
            C C P   G  C  C PG+Y    G    RC  C+  G +N QC   +G C  CQ    G
Sbjct: 1654 CACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSN-QCQDGSGICVNCQHNTAG 1712

Query: 963  QHCERCEVNHFGFGPEG-CKPCDCHPEGSLSLQCKDDG---RCECREGFVGNRCDQCEEN 1018
            +HCERC+  ++G    G C+ C C    S +  C  +G   RC C+ G+ G +C++C   
Sbjct: 1713 EHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPG 1772

Query: 1019 YFYNRSWPG--CQECP--------ACYRLVKD------KVADHRVKLQELESLIANLGTG 1062
            YF N    G  CQ C         +C+ L  D      K +    +  + +S +  L   
Sbjct: 1773 YFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDCDSCVMTLLND 1832

Query: 1063 DEMVTDQAFEDRLKEAEREVMD----LLREAQDVKDVDQNLMDRLQRVNNTLSSQISRLQ 1118
               + +Q    RL +++ + +     LL + + ++   ++L ++L    + +S+  S+++
Sbjct: 1833 LATMGEQL---RLVKSQLQGLSASAGLLEQMRHMETQAKDLRNQLLNYRSAISNHGSKIE 1889

Query: 1119 NIRNTIEETGNLAEQARAHVENTERLIEIASRELEKAKVAAANVSVTQPESTGDPNNMTL 1178
             +   + +     E  +   +   R  +  +  + +A  +A  + V   +      N+ +
Sbjct: 1890 GLERELTDLNQEFETLQEKAQVNSRKAQTLNNNVNRATQSAKELDV---KIKNVIRNVHM 1946

Query: 1179 LAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIEELNRKYEQ 1238
            L    R   + H+ E + +   A +  D+  E Y   L  L         ++E   + +Q
Sbjct: 1947 L-NRIRTWQKTHQGENNGL---ANSIRDSLNE-YEAKLSDLRA------RLQEAAAQAKQ 1995

Query: 1239 AKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLSPLDSETLENEANNIKMEAENLEQ 1298
            A  ++Q+ E+    +  + K       +       L+  DS  L+    NI +      Q
Sbjct: 1996 ANGLNQENERALGAIQRQVKEINSLQSDF---TKYLTTADSSLLQ---TNIAL------Q 2043

Query: 1299 LIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQQTADQLLARADAAKALAEEAAKKGRD 1358
            L+++  K+YE L   +     E+ + + +           L+R+    +L EEA K  R 
Sbjct: 2044 LMEKSQKEYEKLAASLNEARQELSDKVRE-----------LSRSAGKTSLVEEAEKHAR- 2091

Query: 1359 TLQEANDILNNLK------DFDRRVNDNKTAAEEALRKIPAINQTITEANEKTREAQQAL 1412
            +LQE    L  +K      +  R   D  TA E  L  I A             +A    
Sbjct: 2092 SLQELAKQLEEIKRNASGDELVRCAVDAATAYENILNAIKA-----------AEDAANRA 2140

Query: 1413 GSAAADATEAKNKAHEAERIASAVQKNATSTKAEAERTFAEVTDLDNEVNNMLKQLQEAE 1472
             SA+  A +   K  +  R A  +  N+     EA+ T  +   L  EV+  L  LQ+  
Sbjct: 2141 ASASESALQTVIK-EDLPRKAKTLSSNSDKLLNEAKMTQKK---LKQEVSPALNNLQQTL 2196

Query: 1473 KELKRKQDDADQDMMMAGMASQAAQEAEINA--RKAKNSVTSLLSIINDLLEQLGQLDTV 1530
              +  +++  D ++          Q  +I+A    AK+ V     I +++L+ L  + T 
Sbjct: 2197 NIVTVQKEVIDTNLTTLRDGLHGIQRGDIDAMISSAKSMVRKANDITDEVLDGLNPIQT- 2255

Query: 1531 DLNKLNEIEGTLNKAKDEMKVSDLDRKVSDLENEAKKQEAAIMDYNRDIEEIMKDIRNLE 1590
            D+ ++ +  G       +  ++D D  V+ L N+       I   N+ +  +     N++
Sbjct: 2256 DVERIKDTYGRTQNEDFKKALTDADNSVNKLTNKLPDLWRKIESINQQLLPLGNISDNMD 2315

Query: 1591 DIRKTL 1596
             IR+ +
Sbjct: 2316 RIRELI 2321



 Score =  130 bits (328), Expect = 8e-30
 Identities = 82/245 (33%), Positives = 113/245 (46%), Gaps = 24/245 (9%)

Query: 265 NDPKVLKSYY--YAISDFAVGG--RCKCNG-HASECMKNEFDKLVCNCKHNTYGVDCEKC 319
           N  +  K YY  Y +   A  G   C C+  HA  C +       C+CK N +G +CEKC
Sbjct: 401 NCEQCAKGYYRPYGVPVDAPDGCIPCSCDPEHADGCEQGSGR---CHCKPNFHGDNCEKC 457

Query: 320 ------LPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDN 373
                  PF    P    +  S+ + +  D  G   +C  +  L       G C  C+  
Sbjct: 458 AIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGC--DCNLEGVLPEICDAHGRCL-CRPG 514

Query: 374 TDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSY-GRCSCKPGVMGDKCDRCQP 432
            +G  C+ CR  F+       C +C CS +GS    C S  G+C C+PGV G +CDRC  
Sbjct: 515 VEGPRCDTCRSGFYSF---PICQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCDRCLS 571

Query: 433 GFHSLTEAGCRPCSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGC 492
           G +          +CDP+G+I   N   G C CK +VEG  C RCK  ++NL+  NP GC
Sbjct: 572 GAYDFPHCQGSSSACDPAGTI---NSNLGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGC 628

Query: 493 TPCFC 497
           + C C
Sbjct: 629 SECKC 633



 Score =  128 bits (322), Expect = 4e-29
 Identities = 148/760 (19%), Positives = 287/760 (37%), Gaps = 125/760 (16%)

Query: 795  CPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIY 854
            CP    G  C+ C  GY+ D  G       C  C C+ + +      C   +G C+ C +
Sbjct: 1656 CPPAYAGDSCQGCSPGYYRDHKGLY--TGRCVPCNCNGHSN-----QCQDGSGICVNCQH 1708

Query: 855  NTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQ 914
            NTAG +C+RC++G++GN +  +    C+AC C    +       N    +C C    TG 
Sbjct: 1709 NTAGEHCERCQEGYYGNAVHGS----CRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGT 1764

Query: 915  DCGACDPGFYN--LQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNH 972
             C  C PG++    + G  C+ C C++ G   G C   TG C  Q        E C+   
Sbjct: 1765 QCERCAPGYFGNPQKFGGSCQPCSCNSNGQL-GSCHPLTGDCINQEPKDSSPAEECD--- 1820

Query: 973  FGFGPEGCKPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECP 1032
                      CD                  C    + +     E+         G     
Sbjct: 1821 ---------DCD-----------------SCVMTLLNDLATMGEQLRLVKSQLQGLSASA 1854

Query: 1033 AC---YRLVKDKVADHRVKLQELESLIANLGTGDEMVTDQAFEDRLKEAEREVMDLLREA 1089
                  R ++ +  D R +L    S I+N G+            +++  ERE+ DL +E 
Sbjct: 1855 GLLEQMRHMETQAKDLRNQLLNYRSAISNHGS------------KIEGLERELTDLNQEF 1902

Query: 1090 QDVKDVDQNLMDRLQRVNNTLSSQIS-------RLQNIRNTIEETGNLAEQARAHVENTE 1142
            + +++  Q    + Q +NN ++           +++N+   +     +    + H     
Sbjct: 1903 ETLQEKAQVNSRKAQTLNNNVNRATQSAKELDVKIKNVIRNVHMLNRIRTWQKTHQGENN 1962

Query: 1143 RLIEIASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRVAK 1202
             L       L + +   +++     E+          A++A  L + +++    I R  K
Sbjct: 1963 GLANSIRDSLNEYEAKLSDLRARLQEAAAQ-------AKQANGLNQENERALGAIQRQVK 2015

Query: 1203 TANDTSTEAYNLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGD 1262
              N   ++    L    +   QT   ++ + +         ++ EK AA ++E  +   D
Sbjct: 2016 EINSLQSDFTKYLTTADSSLLQTNIALQLMEKS-------QKEYEKLAASLNEARQELSD 2068

Query: 1263 KAVEIYASVAQLSPLDSETLENEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKEL--- 1319
            K  E+  S  + S ++             EAE   + + +  K  E+++ +  G EL   
Sbjct: 2069 KVRELSRSAGKTSLVE-------------EAEKHARSLQELAKQLEEIKRNASGDELVRC 2115

Query: 1320 ------EVKNLLEKGKTEQQTADQLLARADAA--KALAEEAAKKGRDTLQEANDILNNLK 1371
                    +N+L   K  +  A++  + +++A    + E+  +K +     ++ +LN  K
Sbjct: 2116 AVDAATAYENILNAIKAAEDAANRAASASESALQTVIKEDLPRKAKTLSSNSDKLLNEAK 2175

Query: 1372 DFDRRVNDNKTAAEEALRK---IPAINQTITEANEKT-REAQQALGSAAADA--TEAKNK 1425
               +++    + A   L++   I  + + + + N  T R+    +     DA  + AK+ 
Sbjct: 2176 MTQKKLKQEVSPALNNLQQTLNIVTVQKEVIDTNLTTLRDGLHGIQRGDIDAMISSAKSM 2235

Query: 1426 AHEAERIASAVQKNATSTKAEAER---TFAE---------VTDLDNEVNNMLKQLQEAEK 1473
              +A  I   V       + + ER   T+           +TD DN VN +  +L     
Sbjct: 2236 VRKANDITDEVLDGLNPIQTDVERIKDTYGRTQNEDFKKALTDADNSVNKLTNKL----P 2291

Query: 1474 ELKRKQDDADQDMMMAGMASQAAQEAEINARKAKNSVTSL 1513
            +L RK +  +Q ++  G  S          ++A+++ + +
Sbjct: 2292 DLWRKIESINQQLLPLGNISDNMDRIRELIQQARDAASKV 2331



 Score =  124 bits (312), Expect = 6e-28
 Identities = 75/245 (30%), Positives = 113/245 (46%), Gaps = 28/245 (11%)

Query: 828  CQCSDNIDPNAVG-NCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNC 886
            C+C       A G +C+   G+C  C  N  G  C RC  G +G P       +CK C+C
Sbjct: 1266 CECHPT---GATGPHCSPEGGQC-PCQPNVIGRQCTRCATGHYGFP-------RCKPCSC 1314

Query: 887  NLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNG- 945
                    +  C  +TGQC C P      C  C+   ++     GCE C+C   G+    
Sbjct: 1315 G-------RRLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEAA 1367

Query: 946  --QCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDD-GRCE 1002
              +CD  +GQC C+P ITG+ C+RC    + F PE C PC+C+ +G+    C    G C 
Sbjct: 1368 MPECDRDSGQCRCKPRITGRQCDRCASGFYRF-PE-CVPCNCNRDGTEPGVCDPGTGACL 1425

Query: 1003 CREGFVGNRCDQCEENYFY--NRSWPGCQECPACYRLVKDKVADHRVKLQELESLIANLG 1060
            C+E   G  C+ C E  F+    +  GC  C  C+ +     + H+ + + ++ L  +L 
Sbjct: 1426 CKENVEGTECNVCREGSFHLDPANLKGCTSC-FCFGVNNQCHSSHKRRTKFVDMLGWHLE 1484

Query: 1061 TGDEM 1065
            T D +
Sbjct: 1485 TADRV 1489



 Score =  115 bits (287), Expect = 4e-25
 Identities = 74/230 (32%), Positives = 100/230 (43%), Gaps = 36/230 (15%)

Query: 724  CACNGHSET---CDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSS 780
            C C+    T   C PE G C C+ N  G  C +C+ G+YG         C+PC C G   
Sbjct: 1266 CECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYG------FPRCKPCSC-GRRL 1318

Query: 781  CAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCS-DNIDPNAV 839
            C  +          CP  T   +CE+C+   F        P+  C  C CS       A+
Sbjct: 1319 CEEMTGQ-----CRCPPRTVRPQCEVCETHSFS-----FHPMAGCEGCNCSRRGTIEAAM 1368

Query: 840  GNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCN 899
              C+R +G+C +C     G  CDRC  GF+  P       +C  CNCN  GT  +   C+
Sbjct: 1369 PECDRDSGQC-RCKPRITGRQCDRCASGFYRFP-------ECVPCNCNRDGT--EPGVCD 1418

Query: 900  PVTGQCECLPHVTGQDCGACDPGFYNLQSG--QGCERCDCHALGSTNGQC 947
            P TG C C  +V G +C  C  G ++L     +GC  C C  +   N QC
Sbjct: 1419 PGTGACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFCFGV---NNQC 1465



 Score =  109 bits (272), Expect = 2e-23
 Identities = 59/195 (30%), Positives = 85/195 (43%), Gaps = 27/195 (13%)

Query: 795  CPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIY 854
            C     G++C  C  G++G P         C+ C C   +       C  +TG+C +C  
Sbjct: 1287 CQPNVIGRQCTRCATGHYGFPR--------CKPCSCGRRL-------CEEMTGQC-RCPP 1330

Query: 855  NTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQ-QSSCNPVTGQCECLPHVTG 913
             T    C+ C+   F      +P   C+ CNC+  GT++     C+  +GQC C P +TG
Sbjct: 1331 RTVRPQCEVCETHSFSF----HPMAGCEGCNCSRRGTIEAAMPECDRDSGQCRCKPRITG 1386

Query: 914  QDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHF 973
            + C  C  GFY       C  C+C+  G+  G CD  TG C C+  + G  C  C    F
Sbjct: 1387 RQCDRCASGFYRFPE---CVPCNCNRDGTEPGVCDPGTGACLCKENVEGTECNVCREGSF 1443

Query: 974  GFGP---EGCKPCDC 985
               P   +GC  C C
Sbjct: 1444 HLDPANLKGCTSCFC 1458



 Score = 97.8 bits (242), Expect = 7e-20
 Identities = 50/154 (32%), Positives = 70/154 (45%), Gaps = 16/154 (10%)

Query: 883  ACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGS 942
            A  C  + T      C+P  GQC C P+V G+ C  C  G Y       C+ C C     
Sbjct: 1263 ALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPR---CKPCSC----- 1314

Query: 943  TNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGP-EGCKPCDCHPEGSLSL---QC-KD 997
                C+  TGQC C P      CE CE + F F P  GC+ C+C   G++     +C +D
Sbjct: 1315 GRRLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEAAMPECDRD 1374

Query: 998  DGRCECREGFVGNRCDQCEENYFYNRSWPGCQEC 1031
             G+C C+    G +CD+C   ++    +P C  C
Sbjct: 1375 SGQCRCKPRITGRQCDRCASGFY---RFPECVPC 1405



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 61/212 (28%), Positives = 94/212 (44%), Gaps = 28/212 (13%)

Query: 280 FAVGGRCKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASEC 339
           F +   C C+   S  M        C C+    G  C++CL    D P            
Sbjct: 530 FPICQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCDRCLSGAYDFP------------ 577

Query: 340 LPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLG--NNEACSS 397
               C G S  C  DP       + G+C  C+ + +G  C RC+  ++ L   N   CS 
Sbjct: 578 ---HCQGSSSAC--DPA-GTINSNLGYC-QCKLHVEGPTCSRCKLLYWNLDKENPSGCSE 630

Query: 398 CHCSPVGSLST--QC-DSYGRCSCKPGVMGDKCDRCQPGFHSLTEA---GCRPCSCDPSG 451
           C C   G++S   +C    G C CK  V GD CD C+ G+ +L ++   GC+ C CD  G
Sbjct: 631 CKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGG 690

Query: 452 SIDE-CNIETGRCVCKDNVEGFNCERCKPGFF 482
           ++   C+  +G C C+++V G  C+R +  ++
Sbjct: 691 ALSSMCSGPSGVCQCREHVVGKVCQRPENNYY 722



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 37/103 (35%), Positives = 50/103 (48%), Gaps = 8/103 (7%)

Query: 930  QGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEG 989
            +G   C+CH  G+T   C    GQC CQP + G+ C RC   H+GF    CKPC C    
Sbjct: 1261 KGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGF--PRCKPCSCGRR- 1317

Query: 990  SLSLQCKD-DGRCECREGFVGNRCDQCEENYFYNRSWPGCQEC 1031
                 C++  G+C C    V  +C+ CE + F      GC+ C
Sbjct: 1318 ----LCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGC 1356



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 45/156 (28%), Positives = 62/156 (39%), Gaps = 28/156 (17%)

Query: 286  CKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPC-DC 344
            C CNGH+++C       +  NC+HNT G  CE+C     +  +  A   S   C PC   
Sbjct: 1687 CNCNGHSNQCQDGS--GICVNCQHNTAGEHCERC----QEGYYGNAVHGSCRAC-PCPHT 1739

Query: 345  NGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNE----ACSSCHC 400
            N  +  C  +       G    C +C+    G  CERC   +F  GN +    +C  C C
Sbjct: 1740 NSFATGCVVN-------GGDVRC-SCKAGYTGTQCERCAPGYF--GNPQKFGGSCQPCSC 1789

Query: 401  SPVGSLSTQCDSYGRC------SCKPGVMGDKCDRC 430
            +  G L +     G C         P    D CD C
Sbjct: 1790 NSNGQLGSCHPLTGDCINQEPKDSSPAEECDDCDSC 1825



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 23/90 (25%), Positives = 41/90 (45%), Gaps = 4/90 (4%)

Query: 958  PGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCK-DDGRCECREGFVGNRCDQCE 1016
            P    + C+    +   F  +G  PC+CHP G+    C  + G+C C+   +G +C +C 
Sbjct: 1241 PQTASRFCKNSARSLVAFYHKGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCA 1300

Query: 1017 ENYFYNRSWPGCQECPACYRLVKDKVADHR 1046
              ++    +P C+ C    RL ++     R
Sbjct: 1301 TGHY---GFPRCKPCSCGRRLCEEMTGQCR 1327



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 24/58 (41%), Positives = 30/58 (51%), Gaps = 6/58 (10%)

Query: 441  GCRPCSCDPSGSID-ECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFC 497
            G  PC C P+G+    C+ E G+C C+ NV G  C RC  G +      PR C PC C
Sbjct: 1262 GALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGF----PR-CKPCSC 1314


>gi|62868217 laminin, beta 3 precursor [Homo sapiens]
          Length = 1172

 Score =  276 bits (707), Expect = 9e-74
 Identities = 160/464 (34%), Positives = 235/464 (50%), Gaps = 42/464 (9%)

Query: 65  ATNTCG-TPPEEYCVQTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQSQTM 123
           A++TCG T PE YC Q G   +   C  CD+ QPH  +        ++     WWQSQ  
Sbjct: 43  ASSTCGLTKPETYCTQYGEWQM--KCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQND 100

Query: 124 LAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCE 183
           +      + ++L L L + F +  V ++F    P    I + +     W  YQY +  C 
Sbjct: 101 V------NPVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCT 154

Query: 184 NTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEW 243
           +T+ +  +G  ++  D +        +  + L GG V  + ++   S      S  +QE 
Sbjct: 155 STFPRVRQGRPQSWQDVRCQSLPQRPN--ARLNGGKVQLNLMD-LVSGIPATQSQKIQEV 211

Query: 244 VTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEFDKL 303
              T++RV   RL       ++ P    S YYA+S   + G C C+GHA  C        
Sbjct: 212 GEITNLRVNFTRLAPVPQRGYHPP----SAYYAVSQLRLQGSCFCHGHADRCAPKPGASA 267

Query: 304 ----------VCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYF 353
                     VC C+HNT G +CE+C PF+N+RPWR A  + A EC  CDCNG S+ C+F
Sbjct: 268 GPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHF 327

Query: 354 DPELYRST--GHGGHCTNCQDNTDGAHCERCRENFFR-----LGNNEACSSCHCSPVGSL 406
           DP ++ ++   +GG C NC+D+T+G +CERC+ ++FR         E C SC C P G++
Sbjct: 328 DPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAV 387

Query: 407 -STQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEA---GCRPCSCDPSGSIDE--CNIE 459
               CD   G+C CK  V G++CD C+PGF  LT A   GC  C C+  GS  +  C+ E
Sbjct: 388 PGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEE 447

Query: 460 TGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSV 503
           +GRC+C  NV G  C++C P  + L S   +GC PC C  H+S+
Sbjct: 448 SGRCLCLPNVVGPKCDQCAPYHWKLASG--QGCEPCACDPHNSL 489



 Score =  253 bits (647), Expect = 8e-67
 Identities = 228/943 (24%), Positives = 387/943 (41%), Gaps = 108/943 (11%)

Query: 724  CACNGHSETCDPETG-------------VCNCRDNTAGPHCEKCSDGY----YGDSTAGT 766
            C C+GH++ C P+ G             VC C+ NTAGP+CE+C+  Y    +  +    
Sbjct: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309

Query: 767  SSDCQPCPCPGGS-SCAVVPKTKEV-------VCTNCPTGTTGKRCELCDDGYFGDPLGR 818
            + +CQ C C G S +C   P            VC NC   T GK CE C   YF +    
Sbjct: 310  AHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPG 369

Query: 819  NGPVRLCRLCQCS-DNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNP 877
                  C  C+C  D   P A   C+ +TG+C+ C  +  G  CD CK GF G   A NP
Sbjct: 370  ASIQETCISCECDPDGAVPGAP--CDPVTGQCV-CKEHVQGERCDLCKPGFTGLTYA-NP 425

Query: 878  ADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDC 937
               C  C+CN+ G+ ++   C+  +G+C CLP+V G  C  C P  + L SGQGCE C C
Sbjct: 426  QG-CHRCDCNILGS-RRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCAC 483

Query: 938  HALGSTNGQCDIRTGQCECQPGITGQHC-----ERCEVNHFGFGPEGCKPCDCHPEGSLS 992
                S + QC+  TGQC C+ G  G  C      +C    +G    GC+ CDC   G+  
Sbjct: 484  DPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEG 543

Query: 993  LQC-KDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPACYRLVKDKVADHRVKLQE 1051
              C K  GRC CR G  G RCDQC+  Y  NR +P C  C  C++     + +  ++   
Sbjct: 544  PGCDKASGRCLCRPGLTGPRCDQCQRGY-CNR-YPVCVACHPCFQTYDADLREQALRFGR 601

Query: 1052 LESLIANLGTGDEMVTDQAFEDRLKEAEREVMDLLREAQDVKDVDQNLMDRLQRVNNTLS 1111
            L +  A+L +G  +  D+    R+ +A+ ++ + +R       V +  + ++     +L 
Sbjct: 602  LRNATASLWSGPGL-EDRGLASRILDAKSKI-EQIRAVLSSPAVTEQEVAQVASAILSLR 659

Query: 1112 SQISRLQNIRNTIEETGNLAEQARAHVENTERLIEIASRELEKAKVAAANVSVTQPESTG 1171
              +  LQ      EET +L     +   +   L+ +  R+ E+           +  S+ 
Sbjct: 660  RTLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQ----------FEKISSA 709

Query: 1172 DPNNMTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIEE 1231
            DP+    +   A + + +  Q+  D  R+     D+  EA  L+ +   G    + ++  
Sbjct: 710  DPSGAFRMLSTAYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVA 769

Query: 1232 LNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLSPLDSET-LENEANNIK 1290
            L  +     +++    K      +        A    +   +L P D+ T   +    + 
Sbjct: 770  LRLEMSSLPDLTPTFNKLCGNSRQ-------MACTPISCPGELCPQDNGTACGSRCRGVL 822

Query: 1291 MEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQQTADQLLARADAAKALAE 1350
              A     +  Q  +        ++     ++   E     Q +A +L  +  A+++  E
Sbjct: 823  PRAGGAFLMAGQVAEQLRGFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQME 882

Query: 1351 EAAKKGRDTLQEANDILNN-------LKDFDRRV------NDNKTAAEEALRKIPAINQT 1397
            E  ++ R  +Q+  D L +       +++    V       D+ T  ++ + +I AI   
Sbjct: 883  EDVRRTRLLIQQVRDFLTDPDTDAATIQEVSEAVLALWLPTDSATVLQK-MNEIQAIAAR 941

Query: 1398 ITEANEKTREAQQALGSA---AADATEAKNKAHEAE----------RIASAVQKNATSTK 1444
            +   +    + +Q +  A    A+A EA+++AH  E          R  +   + A  T 
Sbjct: 942  LPNVDLVLSQTKQDIARARRLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTM 1001

Query: 1445 AEAERTFAEVTD-----------LDNEVNNMLKQLQEAEKELKRKQDDADQDMMMAGMAS 1493
                R+   + D            +  V +M KQL +    ++  +  A Q    A  A 
Sbjct: 1002 QGTSRSLRLIQDRVAEVQQVLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQ 1061

Query: 1494 QAAQEAEINARKAKNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDEM---- 1549
            Q A+ A   A  A+     +     +L ++LGQ      + L E    +   K E     
Sbjct: 1062 QLAEGASEQALSAQEGFERIKQKYAELKDRLGQ-----SSMLGEQGARIQSVKTEAEELF 1116

Query: 1550 -KVSDLDRKVSDLENEAKKQEAAIMDYNRDIEEIMKDIRNLED 1591
             +  ++  ++ D+E E  +   AIM  + D+  + K +  + D
Sbjct: 1117 GETMEMMDRMKDMELELLRGSQAIMLRSADLTGLEKRVEQIRD 1159



 Score =  103 bits (258), Expect = 1e-21
 Identities = 62/201 (30%), Positives = 89/201 (44%), Gaps = 23/201 (11%)

Query: 305 CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCN--GRSQECYFDPELYRSTG 362
           C CK +  G  C+ C P F        T  +   C  CDCN  G  ++   D E      
Sbjct: 399 CVCKEHVQGERCDLCKPGFTG-----LTYANPQGCHRCDCNILGSRRDMPCDEE------ 447

Query: 363 HGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSY-GRCSCKPG 421
             G C  C  N  G  C++C    ++L + + C  C C P  SLS QC+ + G+C C+ G
Sbjct: 448 -SGRCL-CLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREG 505

Query: 422 VMGDKCD-----RCQPGFHSLTEAGCRPCSCDPSGSIDE-CNIETGRCVCKDNVEGFNCE 475
             G  C      +C    +     GCR C CD  G+    C+  +GRC+C+  + G  C+
Sbjct: 506 FGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCD 565

Query: 476 RCKPGFFNLESSNPRGCTPCF 496
           +C+ G+ N        C PCF
Sbjct: 566 QCQRGYCN-RYPVCVACHPCF 585



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 31/97 (31%), Positives = 39/97 (40%), Gaps = 25/97 (25%)

Query: 414 GRCSCKPGVMGDKCDRCQPGFHSLTEAGCRP-CSCDPSGSIDECNIETGRCVCKDNVEGF 472
           G C C         DRC P          +P  S  PS ++   ++    CVC+ N  G 
Sbjct: 248 GSCFCH-----GHADRCAP----------KPGASAGPSTAVQVHDV----CVCQHNTAGP 288

Query: 473 NCERCKPGFFN-----LESSNPRGCTPCFCFGHSSVC 504
           NCERC P + N      E  +   C  C C GHS  C
Sbjct: 289 NCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETC 325


>gi|62868215 laminin, beta 3 precursor [Homo sapiens]
          Length = 1172

 Score =  276 bits (707), Expect = 9e-74
 Identities = 160/464 (34%), Positives = 235/464 (50%), Gaps = 42/464 (9%)

Query: 65  ATNTCG-TPPEEYCVQTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQSQTM 123
           A++TCG T PE YC Q G   +   C  CD+ QPH  +        ++     WWQSQ  
Sbjct: 43  ASSTCGLTKPETYCTQYGEWQM--KCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQND 100

Query: 124 LAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCE 183
           +      + ++L L L + F +  V ++F    P    I + +     W  YQY +  C 
Sbjct: 101 V------NPVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCT 154

Query: 184 NTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEW 243
           +T+ +  +G  ++  D +        +  + L GG V  + ++   S      S  +QE 
Sbjct: 155 STFPRVRQGRPQSWQDVRCQSLPQRPN--ARLNGGKVQLNLMD-LVSGIPATQSQKIQEV 211

Query: 244 VTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEFDKL 303
              T++RV   RL       ++ P    S YYA+S   + G C C+GHA  C        
Sbjct: 212 GEITNLRVNFTRLAPVPQRGYHPP----SAYYAVSQLRLQGSCFCHGHADRCAPKPGASA 267

Query: 304 ----------VCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYF 353
                     VC C+HNT G +CE+C PF+N+RPWR A  + A EC  CDCNG S+ C+F
Sbjct: 268 GPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHF 327

Query: 354 DPELYRST--GHGGHCTNCQDNTDGAHCERCRENFFR-----LGNNEACSSCHCSPVGSL 406
           DP ++ ++   +GG C NC+D+T+G +CERC+ ++FR         E C SC C P G++
Sbjct: 328 DPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAV 387

Query: 407 -STQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEA---GCRPCSCDPSGSIDE--CNIE 459
               CD   G+C CK  V G++CD C+PGF  LT A   GC  C C+  GS  +  C+ E
Sbjct: 388 PGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEE 447

Query: 460 TGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSV 503
           +GRC+C  NV G  C++C P  + L S   +GC PC C  H+S+
Sbjct: 448 SGRCLCLPNVVGPKCDQCAPYHWKLASG--QGCEPCACDPHNSL 489



 Score =  253 bits (647), Expect = 8e-67
 Identities = 228/943 (24%), Positives = 387/943 (41%), Gaps = 108/943 (11%)

Query: 724  CACNGHSETCDPETG-------------VCNCRDNTAGPHCEKCSDGY----YGDSTAGT 766
            C C+GH++ C P+ G             VC C+ NTAGP+CE+C+  Y    +  +    
Sbjct: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309

Query: 767  SSDCQPCPCPGGS-SCAVVPKTKEV-------VCTNCPTGTTGKRCELCDDGYFGDPLGR 818
            + +CQ C C G S +C   P            VC NC   T GK CE C   YF +    
Sbjct: 310  AHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPG 369

Query: 819  NGPVRLCRLCQCS-DNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNP 877
                  C  C+C  D   P A   C+ +TG+C+ C  +  G  CD CK GF G   A NP
Sbjct: 370  ASIQETCISCECDPDGAVPGAP--CDPVTGQCV-CKEHVQGERCDLCKPGFTGLTYA-NP 425

Query: 878  ADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDC 937
               C  C+CN+ G+ ++   C+  +G+C CLP+V G  C  C P  + L SGQGCE C C
Sbjct: 426  QG-CHRCDCNILGS-RRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCAC 483

Query: 938  HALGSTNGQCDIRTGQCECQPGITGQHC-----ERCEVNHFGFGPEGCKPCDCHPEGSLS 992
                S + QC+  TGQC C+ G  G  C      +C    +G    GC+ CDC   G+  
Sbjct: 484  DPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEG 543

Query: 993  LQC-KDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPACYRLVKDKVADHRVKLQE 1051
              C K  GRC CR G  G RCDQC+  Y  NR +P C  C  C++     + +  ++   
Sbjct: 544  PGCDKASGRCLCRPGLTGPRCDQCQRGY-CNR-YPVCVACHPCFQTYDADLREQALRFGR 601

Query: 1052 LESLIANLGTGDEMVTDQAFEDRLKEAEREVMDLLREAQDVKDVDQNLMDRLQRVNNTLS 1111
            L +  A+L +G  +  D+    R+ +A+ ++ + +R       V +  + ++     +L 
Sbjct: 602  LRNATASLWSGPGL-EDRGLASRILDAKSKI-EQIRAVLSSPAVTEQEVAQVASAILSLR 659

Query: 1112 SQISRLQNIRNTIEETGNLAEQARAHVENTERLIEIASRELEKAKVAAANVSVTQPESTG 1171
              +  LQ      EET +L     +   +   L+ +  R+ E+           +  S+ 
Sbjct: 660  RTLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQ----------FEKISSA 709

Query: 1172 DPNNMTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIEE 1231
            DP+    +   A + + +  Q+  D  R+     D+  EA  L+ +   G    + ++  
Sbjct: 710  DPSGAFRMLSTAYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVA 769

Query: 1232 LNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLSPLDSET-LENEANNIK 1290
            L  +     +++    K      +        A    +   +L P D+ T   +    + 
Sbjct: 770  LRLEMSSLPDLTPTFNKLCGNSRQ-------MACTPISCPGELCPQDNGTACGSRCRGVL 822

Query: 1291 MEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQQTADQLLARADAAKALAE 1350
              A     +  Q  +        ++     ++   E     Q +A +L  +  A+++  E
Sbjct: 823  PRAGGAFLMAGQVAEQLRGFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQME 882

Query: 1351 EAAKKGRDTLQEANDILNN-------LKDFDRRV------NDNKTAAEEALRKIPAINQT 1397
            E  ++ R  +Q+  D L +       +++    V       D+ T  ++ + +I AI   
Sbjct: 883  EDVRRTRLLIQQVRDFLTDPDTDAATIQEVSEAVLALWLPTDSATVLQK-MNEIQAIAAR 941

Query: 1398 ITEANEKTREAQQALGSA---AADATEAKNKAHEAE----------RIASAVQKNATSTK 1444
            +   +    + +Q +  A    A+A EA+++AH  E          R  +   + A  T 
Sbjct: 942  LPNVDLVLSQTKQDIARARRLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTM 1001

Query: 1445 AEAERTFAEVTD-----------LDNEVNNMLKQLQEAEKELKRKQDDADQDMMMAGMAS 1493
                R+   + D            +  V +M KQL +    ++  +  A Q    A  A 
Sbjct: 1002 QGTSRSLRLIQDRVAEVQQVLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQ 1061

Query: 1494 QAAQEAEINARKAKNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDEM---- 1549
            Q A+ A   A  A+     +     +L ++LGQ      + L E    +   K E     
Sbjct: 1062 QLAEGASEQALSAQEGFERIKQKYAELKDRLGQ-----SSMLGEQGARIQSVKTEAEELF 1116

Query: 1550 -KVSDLDRKVSDLENEAKKQEAAIMDYNRDIEEIMKDIRNLED 1591
             +  ++  ++ D+E E  +   AIM  + D+  + K +  + D
Sbjct: 1117 GETMEMMDRMKDMELELLRGSQAIMLRSADLTGLEKRVEQIRD 1159



 Score =  103 bits (258), Expect = 1e-21
 Identities = 62/201 (30%), Positives = 89/201 (44%), Gaps = 23/201 (11%)

Query: 305 CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCN--GRSQECYFDPELYRSTG 362
           C CK +  G  C+ C P F        T  +   C  CDCN  G  ++   D E      
Sbjct: 399 CVCKEHVQGERCDLCKPGFTG-----LTYANPQGCHRCDCNILGSRRDMPCDEE------ 447

Query: 363 HGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSY-GRCSCKPG 421
             G C  C  N  G  C++C    ++L + + C  C C P  SLS QC+ + G+C C+ G
Sbjct: 448 -SGRCL-CLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREG 505

Query: 422 VMGDKCD-----RCQPGFHSLTEAGCRPCSCDPSGSIDE-CNIETGRCVCKDNVEGFNCE 475
             G  C      +C    +     GCR C CD  G+    C+  +GRC+C+  + G  C+
Sbjct: 506 FGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCD 565

Query: 476 RCKPGFFNLESSNPRGCTPCF 496
           +C+ G+ N        C PCF
Sbjct: 566 QCQRGYCN-RYPVCVACHPCF 585



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 31/97 (31%), Positives = 39/97 (40%), Gaps = 25/97 (25%)

Query: 414 GRCSCKPGVMGDKCDRCQPGFHSLTEAGCRP-CSCDPSGSIDECNIETGRCVCKDNVEGF 472
           G C C         DRC P          +P  S  PS ++   ++    CVC+ N  G 
Sbjct: 248 GSCFCH-----GHADRCAP----------KPGASAGPSTAVQVHDV----CVCQHNTAGP 288

Query: 473 NCERCKPGFFN-----LESSNPRGCTPCFCFGHSSVC 504
           NCERC P + N      E  +   C  C C GHS  C
Sbjct: 289 NCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETC 325


>gi|189083719 laminin, beta 3 precursor [Homo sapiens]
          Length = 1172

 Score =  276 bits (707), Expect = 9e-74
 Identities = 160/464 (34%), Positives = 235/464 (50%), Gaps = 42/464 (9%)

Query: 65  ATNTCG-TPPEEYCVQTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQSQTM 123
           A++TCG T PE YC Q G   +   C  CD+ QPH  +        ++     WWQSQ  
Sbjct: 43  ASSTCGLTKPETYCTQYGEWQM--KCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQND 100

Query: 124 LAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCE 183
           +      + ++L L L + F +  V ++F    P    I + +     W  YQY +  C 
Sbjct: 101 V------NPVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCT 154

Query: 184 NTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEW 243
           +T+ +  +G  ++  D +        +  + L GG V  + ++   S      S  +QE 
Sbjct: 155 STFPRVRQGRPQSWQDVRCQSLPQRPN--ARLNGGKVQLNLMD-LVSGIPATQSQKIQEV 211

Query: 244 VTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEFDKL 303
              T++RV   RL       ++ P    S YYA+S   + G C C+GHA  C        
Sbjct: 212 GEITNLRVNFTRLAPVPQRGYHPP----SAYYAVSQLRLQGSCFCHGHADRCAPKPGASA 267

Query: 304 ----------VCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYF 353
                     VC C+HNT G +CE+C PF+N+RPWR A  + A EC  CDCNG S+ C+F
Sbjct: 268 GPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHF 327

Query: 354 DPELYRST--GHGGHCTNCQDNTDGAHCERCRENFFR-----LGNNEACSSCHCSPVGSL 406
           DP ++ ++   +GG C NC+D+T+G +CERC+ ++FR         E C SC C P G++
Sbjct: 328 DPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAV 387

Query: 407 -STQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEA---GCRPCSCDPSGSIDE--CNIE 459
               CD   G+C CK  V G++CD C+PGF  LT A   GC  C C+  GS  +  C+ E
Sbjct: 388 PGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEE 447

Query: 460 TGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSV 503
           +GRC+C  NV G  C++C P  + L S   +GC PC C  H+S+
Sbjct: 448 SGRCLCLPNVVGPKCDQCAPYHWKLASG--QGCEPCACDPHNSL 489



 Score =  253 bits (647), Expect = 8e-67
 Identities = 228/943 (24%), Positives = 387/943 (41%), Gaps = 108/943 (11%)

Query: 724  CACNGHSETCDPETG-------------VCNCRDNTAGPHCEKCSDGY----YGDSTAGT 766
            C C+GH++ C P+ G             VC C+ NTAGP+CE+C+  Y    +  +    
Sbjct: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309

Query: 767  SSDCQPCPCPGGS-SCAVVPKTKEV-------VCTNCPTGTTGKRCELCDDGYFGDPLGR 818
            + +CQ C C G S +C   P            VC NC   T GK CE C   YF +    
Sbjct: 310  AHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPG 369

Query: 819  NGPVRLCRLCQCS-DNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNP 877
                  C  C+C  D   P A   C+ +TG+C+ C  +  G  CD CK GF G   A NP
Sbjct: 370  ASIQETCISCECDPDGAVPGAP--CDPVTGQCV-CKEHVQGERCDLCKPGFTGLTYA-NP 425

Query: 878  ADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDC 937
               C  C+CN+ G+ ++   C+  +G+C CLP+V G  C  C P  + L SGQGCE C C
Sbjct: 426  QG-CHRCDCNILGS-RRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCAC 483

Query: 938  HALGSTNGQCDIRTGQCECQPGITGQHC-----ERCEVNHFGFGPEGCKPCDCHPEGSLS 992
                S + QC+  TGQC C+ G  G  C      +C    +G    GC+ CDC   G+  
Sbjct: 484  DPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEG 543

Query: 993  LQC-KDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPACYRLVKDKVADHRVKLQE 1051
              C K  GRC CR G  G RCDQC+  Y  NR +P C  C  C++     + +  ++   
Sbjct: 544  PGCDKASGRCLCRPGLTGPRCDQCQRGY-CNR-YPVCVACHPCFQTYDADLREQALRFGR 601

Query: 1052 LESLIANLGTGDEMVTDQAFEDRLKEAEREVMDLLREAQDVKDVDQNLMDRLQRVNNTLS 1111
            L +  A+L +G  +  D+    R+ +A+ ++ + +R       V +  + ++     +L 
Sbjct: 602  LRNATASLWSGPGL-EDRGLASRILDAKSKI-EQIRAVLSSPAVTEQEVAQVASAILSLR 659

Query: 1112 SQISRLQNIRNTIEETGNLAEQARAHVENTERLIEIASRELEKAKVAAANVSVTQPESTG 1171
              +  LQ      EET +L     +   +   L+ +  R+ E+           +  S+ 
Sbjct: 660  RTLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQ----------FEKISSA 709

Query: 1172 DPNNMTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIEE 1231
            DP+    +   A + + +  Q+  D  R+     D+  EA  L+ +   G    + ++  
Sbjct: 710  DPSGAFRMLSTAYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVA 769

Query: 1232 LNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLSPLDSET-LENEANNIK 1290
            L  +     +++    K      +        A    +   +L P D+ T   +    + 
Sbjct: 770  LRLEMSSLPDLTPTFNKLCGNSRQ-------MACTPISCPGELCPQDNGTACGSRCRGVL 822

Query: 1291 MEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQQTADQLLARADAAKALAE 1350
              A     +  Q  +        ++     ++   E     Q +A +L  +  A+++  E
Sbjct: 823  PRAGGAFLMAGQVAEQLRGFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQME 882

Query: 1351 EAAKKGRDTLQEANDILNN-------LKDFDRRV------NDNKTAAEEALRKIPAINQT 1397
            E  ++ R  +Q+  D L +       +++    V       D+ T  ++ + +I AI   
Sbjct: 883  EDVRRTRLLIQQVRDFLTDPDTDAATIQEVSEAVLALWLPTDSATVLQK-MNEIQAIAAR 941

Query: 1398 ITEANEKTREAQQALGSA---AADATEAKNKAHEAE----------RIASAVQKNATSTK 1444
            +   +    + +Q +  A    A+A EA+++AH  E          R  +   + A  T 
Sbjct: 942  LPNVDLVLSQTKQDIARARRLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTM 1001

Query: 1445 AEAERTFAEVTD-----------LDNEVNNMLKQLQEAEKELKRKQDDADQDMMMAGMAS 1493
                R+   + D            +  V +M KQL +    ++  +  A Q    A  A 
Sbjct: 1002 QGTSRSLRLIQDRVAEVQQVLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQ 1061

Query: 1494 QAAQEAEINARKAKNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDEM---- 1549
            Q A+ A   A  A+     +     +L ++LGQ      + L E    +   K E     
Sbjct: 1062 QLAEGASEQALSAQEGFERIKQKYAELKDRLGQ-----SSMLGEQGARIQSVKTEAEELF 1116

Query: 1550 -KVSDLDRKVSDLENEAKKQEAAIMDYNRDIEEIMKDIRNLED 1591
             +  ++  ++ D+E E  +   AIM  + D+  + K +  + D
Sbjct: 1117 GETMEMMDRMKDMELELLRGSQAIMLRSADLTGLEKRVEQIRD 1159



 Score =  103 bits (258), Expect = 1e-21
 Identities = 62/201 (30%), Positives = 89/201 (44%), Gaps = 23/201 (11%)

Query: 305 CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCN--GRSQECYFDPELYRSTG 362
           C CK +  G  C+ C P F        T  +   C  CDCN  G  ++   D E      
Sbjct: 399 CVCKEHVQGERCDLCKPGFTG-----LTYANPQGCHRCDCNILGSRRDMPCDEE------ 447

Query: 363 HGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSY-GRCSCKPG 421
             G C  C  N  G  C++C    ++L + + C  C C P  SLS QC+ + G+C C+ G
Sbjct: 448 -SGRCL-CLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREG 505

Query: 422 VMGDKCD-----RCQPGFHSLTEAGCRPCSCDPSGSIDE-CNIETGRCVCKDNVEGFNCE 475
             G  C      +C    +     GCR C CD  G+    C+  +GRC+C+  + G  C+
Sbjct: 506 FGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCD 565

Query: 476 RCKPGFFNLESSNPRGCTPCF 496
           +C+ G+ N        C PCF
Sbjct: 566 QCQRGYCN-RYPVCVACHPCF 585



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 31/97 (31%), Positives = 39/97 (40%), Gaps = 25/97 (25%)

Query: 414 GRCSCKPGVMGDKCDRCQPGFHSLTEAGCRP-CSCDPSGSIDECNIETGRCVCKDNVEGF 472
           G C C         DRC P          +P  S  PS ++   ++    CVC+ N  G 
Sbjct: 248 GSCFCH-----GHADRCAP----------KPGASAGPSTAVQVHDV----CVCQHNTAGP 288

Query: 473 NCERCKPGFFN-----LESSNPRGCTPCFCFGHSSVC 504
           NCERC P + N      E  +   C  C C GHS  C
Sbjct: 289 NCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETC 325


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score =  269 bits (688), Expect = 1e-71
 Identities = 186/561 (33%), Positives = 263/561 (46%), Gaps = 65/561 (11%)

Query: 305  CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHG 364
            C+C     G  C+ C   +   P    +      C  C C+G S+ C  +PE        
Sbjct: 1126 CSCPPGYRGPSCQDCDTGYTRTP----SGLYLGTCERCSCHGHSEAC--EPET------- 1172

Query: 365  GHCTNCQDNTDGAHCERCRENFF---RLGNNEACSSCHC---SPVGSLSTQC----DSYG 414
            G C  CQ +T+G  CE+C+  ++   + G  + C  C C      G  +  C    D + 
Sbjct: 1173 GACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHP 1232

Query: 415  RC-SCKPGVMGDKCDRCQPGFHSLTEAG--CRP---------CSCDPSGSIDECNIETGR 462
             C +C PG  G  C+RC PG++     G  C+          C+CDP GS+       G+
Sbjct: 1233 TCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQ 1292

Query: 463  CVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQI- 521
            C CK  VEG  C  C+P  F+L +SNP GC PCFC G +  C ++  Y+ + IS+ F   
Sbjct: 1293 CQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQCASS-AYTRHLISTHFAPG 1351

Query: 522  DEDGWR-AEQRDGSEASLEWSSER-QDIAVISDSYFPR------YFIAPAKFLGKQVLSY 573
            D  G+     +  S  + E++ E   + A +S   F +      Y+  P  + G +V +Y
Sbjct: 1352 DFQGFALVNPQRNSRLTGEFTVEPVPEGAQLSFGNFAQLGHESFYWQLPETYQGDKVAAY 1411

Query: 574  GQNLSF--SFRVDRRDTRLSAEDLVLEGAGLRV--SVPLIAQGNSYPSETTVKYVFRLHE 629
            G  L +  S+    + + LS  D+ + G  + +  S P + QG   P   + + +FR  E
Sbjct: 1412 GGKLRYTLSYTAGPQGSPLSDPDVQITGNNIMLVASQPAL-QG---PERRSYEIMFR-EE 1466

Query: 630  ATDYPWRPALTPFEFQKLLNNLTSIKIRGTYSE-RSAGYLDDVTLASARPGPG--VPATW 686
                P     T       L +L  + IR T+S    A  +  V+L  A+PGP     A  
Sbjct: 1467 FWRRPDGQPATREHLLMALADLDELLIRATFSSVPLAASISAVSLEVAQPGPSNRPRALE 1526

Query: 687  VESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVCN-CRDN 745
            VE C CP GY G  C+ C  GY R    L     C LC CNGHS+ C PETG C+ C+ N
Sbjct: 1527 VEECRCPPGYIGLSCQDCAPGYTRTGSGL-YLGHCELCECNGHSDLCHPETGACSQCQHN 1585

Query: 746  TAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVV------CTNCPTGT 799
             AG  CE C+ GYYGD+TAGT  DCQPC CP  +   +  +T E +      CT C  G 
Sbjct: 1586 AAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGY 1645

Query: 800  TGKRCELCDDGYFGDPLGRNG 820
            TG+ CE C  GY G+P  + G
Sbjct: 1646 TGQYCEQCGPGYVGNPSVQGG 1666



 Score =  262 bits (670), Expect = 2e-69
 Identities = 199/633 (31%), Positives = 276/633 (43%), Gaps = 87/633 (13%)

Query: 305  CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHG 364
            C C     G+ CE C   F   P           C  C+CNG +  C  DP         
Sbjct: 731  CRCPIGYSGLSCESCDAHFTRVPG----GPYLGTCSGCNCNGHASSC--DPVY------- 777

Query: 365  GHCTNCQDNTDGAHCERCRENFF---RLGNNEACSSCHCSPVGS---LSTQC----DSYG 414
            GHC NCQ NT+G  C +C+  FF         +C  C C  + +    S  C    D   
Sbjct: 778  GHCLNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQA 837

Query: 415  RC-SCKPGVMGDKCDRCQPGFHS--LTEAG-CRPCS-----CDPSGSIDECNIETGRCVC 465
             C +C PG  G +C+ C PG+    +   G CRP +     CD  GS+         C C
Sbjct: 838  TCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSG---EACRC 894

Query: 466  KDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAV--------------GYS 511
            K+NV G  C  C  G F+L + NP GC  CFC G S  CT++                +S
Sbjct: 895  KNNVVGRLCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFS 954

Query: 512  VYSISSTFQIDEDGWRAEQRDGSEASLEWSSERQDIAVISDSYFPRYFIAPAKFLGKQVL 571
            + + +ST   +E  +       +   L +SS  +   ++S  YF   +  P++FLG +V 
Sbjct: 955  LTNAASTHTTNEGIF-----SPTPGELGFSSFHR---LLSGPYF---WSLPSRFLGDKVT 1003

Query: 572  SYGQNLSFSF--RVDRRDTRLSAEDLVLEGAGLRVSVPLIAQGNSYPSETTVKYVFRLHE 629
            SYG  L F+   R     T L  + LV+      +    +AQ  S    +T    FR  +
Sbjct: 1004 SYGGELRFTVTQRSQPGSTPLHGQPLVVLQGNNIILEHHVAQEPSPGQPSTFIVPFR-EQ 1062

Query: 630  ATDYPWRPALTPFEFQKLLNNLTSIKIRGTYSERSA-GYLDDVTLASARPGP--GVPATW 686
            A   P     T       L  + ++ IR +Y+++ A   +  +++  A P      PA  
Sbjct: 1063 AWQRPDGQPATREHLLMALAGIDTLLIRASYAQQPAESRVSGISMDVAVPEETGQDPALE 1122

Query: 687  VESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVC-NCRDN 745
            VE C+CP GY G  C+ C +GY R TP+      C  C+C+GHSE C+PETG C  C+ +
Sbjct: 1123 VEQCSCPPGYRGPSCQDCDTGYTR-TPSGLYLGTCERCSCHGHSEACEPETGACQGCQHH 1181

Query: 746  TAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKT------KEVVCTNCPTGT 799
            T GP CE+C  GYYGD+  GT  DCQ CPC G  +      T          C  C  G 
Sbjct: 1182 TEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGH 1241

Query: 800  TGKRCELCDDGYFGD-----PLGRNGPVRLCRLCQCSDNIDP-NAVGNCNRLTGECLKCI 853
            +G+ CE C  GY+G+     P  R+  V     C C    DP  +V +     G+C +C 
Sbjct: 1242 SGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNC----DPQGSVSSQCDAAGQC-QCK 1296

Query: 854  YNTAGFYCDRCKDGFFGNPLAPNPADKCKACNC 886
                G  C  C+   F +  A NP D C  C C
Sbjct: 1297 AQVEGLTCSHCRPHHF-HLSASNP-DGCLPCFC 1327



 Score =  177 bits (448), Expect = 1e-43
 Identities = 134/449 (29%), Positives = 197/449 (43%), Gaps = 66/449 (14%)

Query: 477 CKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAEQRDG--- 533
           C  G F LE S    C PCFCFG +SVC +   +           D+   R +Q D    
Sbjct: 505 CPDGHFYLEHS--AACLPCFCFGITSVCQSTRRFR----------DQIRLRFDQPDDFKG 552

Query: 534 --------------SEASLEWSSERQDIAVISDS----YFPRYFIAPAKFLGKQVLSYGQ 575
                         S   L+      +  ++  S        ++  P +FLG +V SYG 
Sbjct: 553 VNVTMPAQPGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGG 612

Query: 576 NLSFSFRVDRRDTRLSA---EDLVLEGAGLRVSVPLIAQGNS--YPSETTVKYVFRLHEA 630
           +L ++ R +     L      D+VL GAG R    L+++G++   P     + V    E 
Sbjct: 613 SLRYNVRYELARGMLEPVQRPDVVLMGAGYR----LLSRGHTPTQPGALNQRQVQFSEEH 668

Query: 631 TDYPWRPALTPFEFQKLLNNLTSIKIRGTYSERSAGY-LDDVTLASA--RPGPGVPATWV 687
             +     +   E  ++L +L ++ I+  Y+ + A   L D+ + +          A  V
Sbjct: 669 WVHESGRPVQRAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHATSHGRAHSV 728

Query: 688 ESCTCPVGYGGQFCEMCLSGYRRETPNLGPY-SPCVLCACNGHSETCDPETGVC-NCRDN 745
           E C CP+GY G  CE C + + R  P  GPY   C  C CNGH+ +CDP  G C NC+ N
Sbjct: 729 EECRCPIGYSGLSCESCDAHFTR-VPG-GPYLGTCSGCNCNGHASSCDPVYGHCLNCQHN 786

Query: 746 TAGPHCEKCSDGYYGDSTAGTSSDCQPCPCP------GGSSCAVVPKTKEVVCTNCPTGT 799
           T GP C KC  G++GD+   T++ C+PCPCP        S    +    +  C  C  G 
Sbjct: 787 TEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGY 846

Query: 800 TGKRCELCDDGYFGDPLGRNGPVRLC--RLCQCSDNIDPNAVGNCNRLTGECLKCIYNTA 857
           TG+RCE C  GY G+P+   G  R     + +C +     ++G     +GE  +C  N  
Sbjct: 847 TGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDER---GSMGT----SGEACRCKNNVV 899

Query: 858 GFYCDRCKDGFFGNPLAPNPADKCKACNC 886
           G  C+ C DG F   L+    D C  C C
Sbjct: 900 GRLCNECADGSF--HLSTRNPDGCLKCFC 926



 Score =  117 bits (292), Expect = 1e-25
 Identities = 73/225 (32%), Positives = 100/225 (44%), Gaps = 47/225 (20%)

Query: 789  EVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGE 848
            EV   +CP G  G  C+ CD GY   P G    +  C  C C  + +      C   TG 
Sbjct: 1122 EVEQCSCPPGYRGPSCQDCDTGYTRTPSGLY--LGTCERCSCHGHSEA-----CEPETGA 1174

Query: 849  CLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQ---- 904
            C  C ++T G  C++C+ G++G+     P D C+ C C  YG        +P  GQ    
Sbjct: 1175 CQGCQHHTEGPRCEQCQPGYYGDAQRGTPQD-CQLCPC--YG--------DPAAGQAAHT 1223

Query: 905  ----------CE-CLPHVTGQDCGACDPGFY-NLQSGQGCER---------CDCHALGST 943
                      C+ C P  +G+ C  C PG+Y N   GQ C+R         C+C   GS 
Sbjct: 1224 CFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSV 1283

Query: 944  NGQCDIRTGQCECQPGITGQHCERCEVNHFGFG---PEGCKPCDC 985
            + QCD   GQC+C+  + G  C  C  +HF      P+GC PC C
Sbjct: 1284 SSQCDA-AGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFC 1327



 Score =  102 bits (254), Expect = 3e-21
 Identities = 69/220 (31%), Positives = 98/220 (44%), Gaps = 30/220 (13%)

Query: 836  PNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQ 895
            P   G    L  E   C     G  C  C  G+   P        C+ C+C+ +      
Sbjct: 1112 PEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLY-LGTCERCSCHGHS----- 1165

Query: 896  SSCNPVTGQCE-CLPHVTGQDCGACDPGFY-NLQSG--QGCERCDCH---ALGSTNGQCD 948
             +C P TG C+ C  H  G  C  C PG+Y + Q G  Q C+ C C+   A G     C 
Sbjct: 1166 EACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCF 1225

Query: 949  IRTG---QCE-CQPGITGQHCERCEVNHFGFGPEG--CKP---------CDCHPEGSLSL 993
            + T     C+ C PG +G+HCERC   ++G   +G  C+          C+C P+GS+S 
Sbjct: 1226 LDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSS 1285

Query: 994  QCKDDGRCECREGFVGNRCDQCEENYFY-NRSWP-GCQEC 1031
            QC   G+C+C+    G  C  C  ++F+ + S P GC  C
Sbjct: 1286 QCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPC 1325



 Score = 98.6 bits (244), Expect = 4e-20
 Identities = 59/184 (32%), Positives = 83/184 (45%), Gaps = 35/184 (19%)

Query: 285  RCKCNGHASECMKNEFDKLVC-NCKHNTYGVDCEKCLP-FFNDRPWRRATAESASECLPC 342
            RC C+GH+  C   E +   C  C+H+T G  CE+C P ++ D     A   +  +C  C
Sbjct: 1158 RCSCHGHSEAC---EPETGACQGCQHHTEGPRCEQCQPGYYGD-----AQRGTPQDCQLC 1209

Query: 343  DCNG------RSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFF-RLGNNEAC 395
             C G       +  C+ D +     GH   C  C     G HCERC   ++      + C
Sbjct: 1210 PCYGDPAAGQAAHTCFLDTD-----GH-PTCDACSPGHSGRHCERCAPGYYGNPSQGQPC 1263

Query: 396  S---------SCHCSPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEA---GCR 443
                       C+C P GS+S+QCD+ G+C CK  V G  C  C+P    L+ +   GC 
Sbjct: 1264 QRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCL 1323

Query: 444  PCSC 447
            PC C
Sbjct: 1324 PCFC 1327



 Score = 88.6 bits (218), Expect = 4e-17
 Identities = 64/199 (32%), Positives = 91/199 (45%), Gaps = 31/199 (15%)

Query: 785  PKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNR 844
            P+  EV    CP G  G  C+ C  GY     G    +  C LC+C+ + D      C+ 
Sbjct: 1522 PRALEVEECRCPPGYIGLSCQDCAPGY--TRTGSGLYLGHCELCECNGHSDL-----CHP 1574

Query: 845  LTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQ 904
             TG C +C +N AG +C+ C  G++G+  A  P D C+ C C L       +  N  +  
Sbjct: 1575 ETGACSQCQHNAAGEFCELCAPGYYGDATAGTPED-CQPCACPL------TNPENMFSRT 1627

Query: 905  CECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTN---GQCDIRTGQC----ECQ 957
            CE L    G  C AC+PG+    +GQ CE+C    +G+ +   GQC   T Q     E  
Sbjct: 1628 CESL-GAGGYRCTACEPGY----TGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVH 1682

Query: 958  PGIT-----GQHCERCEVN 971
            P  +     G H  RC+V+
Sbjct: 1683 PARSIVPQGGSHSLRCQVS 1701



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 61/205 (29%), Positives = 87/205 (42%), Gaps = 31/205 (15%)

Query: 848  ECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQC-E 906
            EC +C    +G  C+ C   F   P  P     C  CNCN +      SSC+PV G C  
Sbjct: 730  EC-RCPIGYSGLSCESCDAHFTRVPGGPY-LGTCSGCNCNGHA-----SSCDPVYGHCLN 782

Query: 907  CLPHVTGQDCGACDPGFYN---LQSGQGCERCDCHALGST---NGQCDIRT-GQCECQ-- 957
            C  +  G  C  C  GF+      +   C  C C  + ++   +  C + T GQ  C   
Sbjct: 783  CQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDAC 842

Query: 958  -PGITGQHCERCEVNHFG--FGPEG-CKPCD-----CHPEGSLSLQCKDDGRCECREGFV 1008
             PG TG+ CE C   + G    P G C+P +     C   GS+    +    C C+   V
Sbjct: 843  APGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGE---ACRCKNNVV 899

Query: 1009 GNRCDQCEENYFY--NRSWPGCQEC 1031
            G  C++C +  F+   R+  GC +C
Sbjct: 900  GRLCNECADGSFHLSTRNPDGCLKC 924



 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 50/145 (34%), Positives = 63/145 (43%), Gaps = 19/145 (13%)

Query: 904  QCECLPHVTGQDCGACDPGFYNLQSGQ---GCERCDCHALGSTNGQCDIRTGQC-ECQPG 959
            +C C P   G  C  C PG+    SG     CE C+C+        C   TG C +CQ  
Sbjct: 1529 ECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDL---CHPETGACSQCQHN 1585

Query: 960  ITGQHCERCEVNHFGFG----PEGCKPCDC---HPEGSLSLQCKDDG----RC-ECREGF 1007
              G+ CE C   ++G      PE C+PC C   +PE   S  C+  G    RC  C  G+
Sbjct: 1586 AAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGY 1645

Query: 1008 VGNRCDQCEENYFYNRSWPGCQECP 1032
             G  C+QC   Y  N S  G Q  P
Sbjct: 1646 TGQYCEQCGPGYVGNPSVQGGQCLP 1670



 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 45/153 (29%), Positives = 64/153 (41%), Gaps = 21/153 (13%)

Query: 904  QCECLPHVTGQDCGACDPGFYNLQSGQ---GCERCDCHALGSTNGQCDIRTGQC-ECQPG 959
            +C C    +G  C +CD  F  +  G     C  C+C+   S+   CD   G C  CQ  
Sbjct: 730  ECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASS---CDPVYGHCLNCQHN 786

Query: 960  ITGQHCERCEVNHFGFGPEG----CKPCDCHPEGSLSLQCKD------DGR--CE-CREG 1006
              G  C +C+   FG   +     C+PC C P    S +  D      DG+  C+ C  G
Sbjct: 787  TEGPQCNKCKAGFFGDAMKATATSCRPCPC-PYIDASRRFSDTCFLDTDGQATCDACAPG 845

Query: 1007 FVGNRCDQCEENYFYNRSWPGCQECPACYRLVK 1039
            + G RC+ C   Y  N   PG +  P    +V+
Sbjct: 846  YTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVR 878



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 38/119 (31%), Positives = 53/119 (44%), Gaps = 13/119 (10%)

Query: 286  CKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLP-FFNDRPWRRATAESASECLPCDC 344
            C+CNGH+  C  +        C+HN  G  CE C P ++ D     ATA +  +C PC C
Sbjct: 1563 CECNGHSDLC--HPETGACSQCQHNAAGEFCELCAPGYYGD-----ATAGTPEDCQPCAC 1615

Query: 345  NGRSQECYFDPELYRSTGHGGH-CTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSP 402
               + E  F      S G GG+ CT C+    G +CE+C   +     N +     C P
Sbjct: 1616 PLTNPENMFS-RTCESLGAGGYRCTACEPGYTGQYCEQCGPGYV---GNPSVQGGQCLP 1670



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 41/146 (28%), Positives = 62/146 (42%), Gaps = 34/146 (23%)

Query: 848  ECLKCIYNTAGFYCDRCKDGFF--GNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQC 905
            EC +C     G  C  C  G+   G+ L       C+ C CN +  +     C+P TG C
Sbjct: 1529 EC-RCPPGYIGLSCQDCAPGYTRTGSGLY---LGHCELCECNGHSDL-----CHPETGAC 1579

Query: 906  -ECLPHVTGQDCGACDPGFYNLQSG---QGCERC-------------DCHALGSTNGQCD 948
             +C  +  G+ C  C PG+Y   +    + C+ C              C +LG+   +C 
Sbjct: 1580 SQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCT 1639

Query: 949  IRTGQCECQPGITGQHCERCEVNHFG 974
                   C+PG TGQ+CE+C   + G
Sbjct: 1640 A------CEPGYTGQYCEQCGPGYVG 1659



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 38/139 (27%), Positives = 52/139 (37%), Gaps = 14/139 (10%)

Query: 370  CQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCD-SYGRCS-CKPGVMGDKC 427
            C     G  C+ C   + R G+      C        S  C    G CS C+    G+ C
Sbjct: 1532 CPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQHNAAGEFC 1591

Query: 428  DRCQPGFHSLTEAG----CRPCSC---DPSGSIDECNIETG----RCV-CKDNVEGFNCE 475
            + C PG++    AG    C+PC+C   +P           G    RC  C+    G  CE
Sbjct: 1592 ELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCE 1651

Query: 476  RCKPGFFNLESSNPRGCTP 494
            +C PG+    S     C P
Sbjct: 1652 QCGPGYVGNPSVQGGQCLP 1670



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 32/102 (31%), Positives = 43/102 (42%), Gaps = 14/102 (13%)

Query: 408 TQCDSYGR------CSCKPGVMGDKCDRCQPGFHSLTE----AGCRPCSCDPSGSIDECN 457
           T   S+GR      C C  G  G  C+ C   F  +        C  C+C  +G    C+
Sbjct: 717 THATSHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNC--NGHASSCD 774

Query: 458 IETGRCV-CKDNVEGFNCERCKPGFF-NLESSNPRGCTPCFC 497
              G C+ C+ N EG  C +CK GFF +   +    C PC C
Sbjct: 775 PVYGHCLNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPC 816



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 33/93 (35%), Positives = 44/93 (47%), Gaps = 15/93 (16%)

Query: 953  QCECQPGITGQHCERCEVNHFGFGPEG-----CKPCDCHPEGSLSLQCKDD-GRCE-CRE 1005
            QC C PG  G  C+ C+  +    P G     C+ C CH     S  C+ + G C+ C+ 
Sbjct: 1125 QCSCPPGYRGPSCQDCDTGYTRT-PSGLYLGTCERCSCHGH---SEACEPETGACQGCQH 1180

Query: 1006 GFVGNRCDQCEENYF--YNRSWP-GCQECPACY 1035
               G RC+QC+  Y+    R  P  CQ CP CY
Sbjct: 1181 HTEGPRCEQCQPGYYGDAQRGTPQDCQLCP-CY 1212



 Score = 36.2 bits (82), Expect = 0.26
 Identities = 24/76 (31%), Positives = 32/76 (42%), Gaps = 15/76 (19%)

Query: 945  GQC---DIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGR- 1000
            GQC   +  +  C C  G TG  CE  +  H       C P  C P+   +   + DGR 
Sbjct: 3857 GQCHDSESSSYVCVCPAGFTGSRCEHSQALH-------CHPEACGPDA--TCVNRPDGRG 3907

Query: 1001 --CECREGFVGNRCDQ 1014
              C C  G  G RC++
Sbjct: 3908 YTCRCHLGRSGLRCEE 3923



 Score = 35.4 bits (80), Expect = 0.45
 Identities = 82/370 (22%), Positives = 116/370 (31%), Gaps = 84/370 (22%)

Query: 690  CTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVCNCRDNTAGP 749
            C CP G+ G  CE               +S  + C    H E C P+   C  R +  G 
Sbjct: 3869 CVCPAGFTGSRCE---------------HSQALHC----HPEACGPDA-TCVNRPDGRGY 3908

Query: 750  HCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDD 809
             C +C  G  G       +   P     GS  A+   T     T+       +   L  D
Sbjct: 3909 TC-RCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTN----THHELRLDVEFKPLAPD 3963

Query: 810  GYFGDPLGRNGPVR-LCRLCQCSDNID----------------PNAVGNCNRLTGECLKC 852
            G      G++GPV     L     +++                P A+G  +R++ E L  
Sbjct: 3964 GVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHRVSAERLN- 4022

Query: 853  IYNTAGFYCDRCKDGFF----GNPLAPNPADKCKACNCN--LY-GTMKQQSSCNPVTGQC 905
                        KDG      G P+  +   K +  N +  LY G ++     +P T   
Sbjct: 4023 ------------KDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMS 4070

Query: 906  ECLPHVTGQDC--GACDPGFYNLQSGQGCERC----DCHALGSTNGQCDIRTG----QCE 955
                   G+    G      Y+    QG  +C     C      +G   +  G    QC 
Sbjct: 4071 AHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCL 4130

Query: 956  CQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQC 1015
            C+ G  G  CE  E            PC           C+   RC C  GF G RC Q 
Sbjct: 4131 CRDGFKGDLCEHEE-----------NPCQLREPCLHGGTCQGT-RCLCLPGFSGPRCQQG 4178

Query: 1016 EENYFYNRSW 1025
              +      W
Sbjct: 4179 SGHGIAESDW 4188



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 19/46 (41%), Positives = 21/46 (45%), Gaps = 5/46 (10%)

Query: 763  TAGTSSDCQPC---PCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCE 805
            TA   S C  C   PC  G  C    ++   VC  CP G TG RCE
Sbjct: 3838 TAHGISHCPTCRDRPCQNGGQCHD-SESSSYVCV-CPAGFTGSRCE 3881



 Score = 31.6 bits (70), Expect = 6.5
 Identities = 28/102 (27%), Positives = 35/102 (34%), Gaps = 25/102 (24%)

Query: 377  AHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHS 436
            +HC  CR+   + G       CH S   S          C C  G  G +C+  Q   H 
Sbjct: 3843 SHCPTCRDRPCQNGGQ-----CHDSESSSYV--------CVCPAGFTGSRCEHSQ-ALH- 3887

Query: 437  LTEAGCRPCSCDPSGSIDECNIETGR---CVCKDNVEGFNCE 475
                 C P +C P  +    N   GR   C C     G  CE
Sbjct: 3888 -----CHPEACGPDATC--VNRPDGRGYTCRCHLGRSGLRCE 3922


>gi|219842266 usherin isoform B [Homo sapiens]
          Length = 5202

 Score =  245 bits (626), Expect = 2e-64
 Identities = 143/428 (33%), Positives = 227/428 (53%), Gaps = 37/428 (8%)

Query: 101 HGAAFLTDYNNQADTTWWQSQ-TMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPES 159
           H  +F+ D  N   T+W  +  T +  +    +I++ L  G+ + + Y+ ++F + +P  
Sbjct: 340 HPLSFVND--NDVGTSWVSNVFTNITQLNQGVTISVDLENGQ-YQVFYIIIQFFSPQPTE 396

Query: 160 FAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGN 219
             I ++      W  +QY++ +C   +   N G +    ++  ++   + S+ +P + GN
Sbjct: 397 IRIQRKKENSLDWEDWQYFARNC-GAFGMKNNGDL----EKPDSVNCLQLSNFTPYSRGN 451

Query: 220 VAFSTLEG----RPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYY 275
           V FS L      RP   NF N+P LQE+V AT IR   +      +   N    L+  YY
Sbjct: 452 VTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHFHGQYYTTETAVN----LRHRYY 507

Query: 276 AISDFAVGGRCKCNGHASEC-MKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAE 334
           A+ +  + GRC+C+GHA  C   ++  + +C+ +  T G+ C++CLP +ND+P+R+    
Sbjct: 508 AVDEITISGRCQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQV 567

Query: 335 SASECLPCDCNGRSQECYF----DPELYRS-TGHGGHCTNCQDNTDGAHCERCRENFFR- 388
            A  C PC CN  S+ C++    DP  +    G GG C +C+ NT G +CE C++ FFR 
Sbjct: 568 YAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQ 627

Query: 389 LGNN----EACSSCHCSPVGSL--STQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEA- 440
           +G +    + C  C C  VG+   S  CD   G+C+CK  V G +C++CQ GF++L E  
Sbjct: 628 VGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELD 687

Query: 441 --GCRPCSCDPSGSID---ECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPC 495
             GC PC+C+ SG++D    C+  +G+C CK NV G  C+ C  GF  L S N  GC PC
Sbjct: 688 PDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPC 747

Query: 496 FCFGHSSV 503
            C  H SV
Sbjct: 748 QCNLHGSV 755



 Score =  197 bits (500), Expect = 9e-50
 Identities = 114/356 (32%), Positives = 172/356 (48%), Gaps = 29/356 (8%)

Query: 690  CTCPVGYGGQFCEMCLSGYR--RETPNLGPYSPCVLCACNGHSET---CDPETGVCNCRD 744
            C C     G  C+ C  G++  R   ++G    C  C CN H      C+P +G C C+ 
Sbjct: 715  CKCKANVIGLRCDHCNFGFKFLRSFNDVG----CEPCQCNLHGSVNKFCNPHSGQCECKK 770

Query: 745  NTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCP-GGSSCAVVPKTKEVVCTNCPTGTTGKR 803
               G  C+ C + +YG       ++C+ C C   GS    V   K   C  C     G++
Sbjct: 771  EAKGLQCDTCRENFYGLDV----TNCKACDCDTAGSLPGTVCNAKTGQCI-CKPNVEGRQ 825

Query: 804  CELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDR 863
            C  C +G F   L +N    LC  C C      N    CN+ TG+C  C     G  C++
Sbjct: 826  CNKCLEGNFY--LRQNNSF-LCLPCNCDKTGTINGSLLCNKSTGQC-PCKLGVTGLRCNQ 881

Query: 864  CKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGF 923
            C+   +   L  +    C+ C C+  GT+   + C+P++GQC C+P+  G+ C  C PGF
Sbjct: 882  CEPHRYN--LTIDNFQHCQMCECDSLGTLPG-TICDPISGQCLCVPNRQGRRCNQCQPGF 938

Query: 924  Y-NLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPG-ITGQHCERCEVNHFGFGPEG-- 979
            Y +  +  GC  C CH  G+ N  C+  TGQC CQ   I GQ C++C+ ++FGF P+   
Sbjct: 939  YISPGNATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGR 998

Query: 980  CKPCDCHPEGSLSLQCK-DDGRCECREGFVGNRCDQC--EENYFYNRSWPGCQECP 1032
            C+PC+CH  G+L+  C    G+C C++   G++CD C    ++    +  GC + P
Sbjct: 999  CQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTP 1054



 Score =  192 bits (489), Expect = 2e-48
 Identities = 108/323 (33%), Positives = 159/323 (49%), Gaps = 26/323 (8%)

Query: 724  CACNGHSETCD----PETGVCNCRDNTAGPHCEKC----SDGYYGDSTAGTSSDCQPCPC 775
            C C+GH++ CD    P   +C+    T G HC++C    +D  +       + +C+PC C
Sbjct: 518  CQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQC 577

Query: 776  PGGS-SC----AVVPKTKEV------VCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRL 824
               S SC    +V P   E       VC +C   TTG+ CELC D +F         + +
Sbjct: 578  NSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDV 637

Query: 825  CRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKAC 884
            C+ C C      N    C+++ G+C  C  + +G  C++C++GF+   L     D C  C
Sbjct: 638  CKPCDCDTVGTRNGSILCDQIGGQC-NCKRHVSGRQCNQCQNGFYN--LQELDPDGCSPC 694

Query: 885  NCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQ--GCERCDCHALGS 942
            NCN  GT+    +C+  +GQC+C  +V G  C  C+ GF  L+S    GCE C C+  GS
Sbjct: 695  NCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGS 754

Query: 943  TNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSL--SLQCKDDGR 1000
             N  C+  +GQCEC+    G  C+ C  N +G     CK CDC   GSL  ++     G+
Sbjct: 755  VNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQ 814

Query: 1001 CECREGFVGNRCDQCEENYFYNR 1023
            C C+    G +C++C E  FY R
Sbjct: 815  CICKPNVEGRQCNKCLEGNFYLR 837



 Score =  187 bits (475), Expect = 7e-47
 Identities = 121/374 (32%), Positives = 169/374 (45%), Gaps = 56/374 (14%)

Query: 698  GQFCEMCLSGYRRETPNLGPYS---PCVLCACNGHSETC------DP--------ETGVC 740
            G  C+ CL  Y  +    G       C  C CN HS++C      DP          GVC
Sbjct: 546  GLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGGGVC 605

Query: 741  -NCRDNTAGPHCEKCSDGYYGDSTAGTSS--DCQPCPCPGGSSCAVVPKTKEVVC----- 792
             +C  NT G +CE C D ++    A  S+   C+PC C       V  +   ++C     
Sbjct: 606  DDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCD-----TVGTRNGSILCDQIGG 660

Query: 793  -TNCPTGTTGKRCELCDDGYFG----DPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTG 847
              NC    +G++C  C +G++     DP G       C  C C+ +   +    C++ +G
Sbjct: 661  QCNCKRHVSGRQCNQCQNGFYNLQELDPDG-------CSPCNCNTSGTVDGDITCHQNSG 713

Query: 848  ECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCEC 907
            +C KC  N  G  CD C  GF    L       C+ C CNL+G++ +   CNP +GQCEC
Sbjct: 714  QC-KCKANVIGLRCDHCNFGF--KFLRSFNDVGCEPCQCNLHGSVNK--FCNPHSGQCEC 768

Query: 908  LPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQ-CDIRTGQCECQPGITGQHCE 966
                 G  C  C   FY L     C+ CDC   GS  G  C+ +TGQC C+P + G+ C 
Sbjct: 769  KKEAKGLQCDTCRENFYGLDV-TNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCN 827

Query: 967  RCEVNHFGFGPEG---CKPCDCHPEGSL--SLQC-KDDGRCECREGFVGNRCDQCEENYF 1020
            +C   +F         C PC+C   G++  SL C K  G+C C+ G  G RC+QCE  + 
Sbjct: 828  KCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEP-HR 886

Query: 1021 YNRSWPGCQECPAC 1034
            YN +    Q C  C
Sbjct: 887  YNLTIDNFQHCQMC 900



 Score =  184 bits (467), Expect = 6e-46
 Identities = 117/359 (32%), Positives = 163/359 (45%), Gaps = 35/359 (9%)

Query: 690  CTCPVGYGGQFCEMCLSGYRRETPNLGPYSP--CVLCACNGHSE-----TCDPETGVCNC 742
            C C     G+ C  C +G+     NL    P  C  C CN         TC   +G C C
Sbjct: 662  CNCKRHVSGRQCNQCQNGFY----NLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKC 717

Query: 743  RDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGK 802
            + N  G  C+ C+ G+     +     C+PC C    S           C  C     G 
Sbjct: 718  KANVIGLRCDHCNFGFKF-LRSFNDVGCEPCQCNLHGSVNKFCNPHSGQC-ECKKEAKGL 775

Query: 803  RCELCDDGYFGDPLGRNGPVRLCRLCQCSDNID-PNAVGNCNRLTGECLKCIYNTAGFYC 861
            +C+ C + ++G        V  C+ C C      P  V  CN  TG+C+ C  N  G  C
Sbjct: 776  QCDTCRENFYGLD------VTNCKACDCDTAGSLPGTV--CNAKTGQCI-CKPNVEGRQC 826

Query: 862  DRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDP 921
            ++C +G F   L  N +  C  CNC+  GT+     CN  TGQC C   VTG  C  C+P
Sbjct: 827  NKCLEGNFY--LRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEP 884

Query: 922  GFYNL--QSGQGCERCDCHALGSTNGQ-CDIRTGQCECQPGITGQHCERCEVNHFGFGP- 977
              YNL   + Q C+ C+C +LG+  G  CD  +GQC C P   G+ C +C+   F   P 
Sbjct: 885  HRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPG-FYISPG 943

Query: 978  --EGCKPCDCHPEGSLSLQCKD-DGRCECREGFV-GNRCDQCEENYF-YNRSWPGCQEC 1031
               GC PC CH  G+++  C    G+C C++  + G RCDQC+++YF ++     CQ C
Sbjct: 944  NATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPC 1002



 Score =  127 bits (319), Expect = 9e-29
 Identities = 85/303 (28%), Positives = 127/303 (41%), Gaps = 90/303 (29%)

Query: 286 CKCNGHASECMKN------EFDKL-----VCN-CKHNTYGVDCEKCLPFFNDRPWRRATA 333
           C+CN H+  C  N       F+       VC+ C+HNT G +CE C  +F    +R+  A
Sbjct: 575 CQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYF----FRQVGA 630

Query: 334 ESAS--ECLPCDCN--GRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRL 389
           + ++   C PCDC+  G         ++      GG C NC+ +  G  C +C+  F+ L
Sbjct: 631 DPSAIDVCKPCDCDTVGTRNGSILCDQI------GGQC-NCKRHVSGRQCNQCQNGFYNL 683

Query: 390 G--NNEACSSCHCSPVGSLS---TQCDSYGRCSCKPGVMGDKCDRCQPGF---HSLTEAG 441
              + + CS C+C+  G++    T   + G+C CK  V+G +CD C  GF    S  + G
Sbjct: 684 QELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVG 743

Query: 442 CRPCSCDPSGSIDE---------------------------------------------- 455
           C PC C+  GS+++                                              
Sbjct: 744 CEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSL 803

Query: 456 ----CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFC-----FGHSSVCTN 506
               CN +TG+C+CK NVEG  C +C  G F L  +N   C PC C        S +C  
Sbjct: 804 PGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNK 863

Query: 507 AVG 509
           + G
Sbjct: 864 STG 866



 Score =  124 bits (311), Expect = 7e-28
 Identities = 78/242 (32%), Positives = 107/242 (44%), Gaps = 37/242 (15%)

Query: 274 YYAISDFAVGGRCKCNGHASECMKNEF----DKLVCNCKHNTYGVDCEKC------LPFF 323
           +Y + +    G   CN + S  +  +     +   C CK N  G+ C+ C      L  F
Sbjct: 680 FYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSF 739

Query: 324 NDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCR 383
           ND             C PC CN       F         H G C  C+    G  C+ CR
Sbjct: 740 ND-----------VGCEPCQCNLHGSVNKF------CNPHSGQC-ECKKEAKGLQCDTCR 781

Query: 384 ENFFRLGNNEACSSCHCSPVGSL-STQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEAG 441
           ENF+ L     C +C C   GSL  T C++  G+C CKP V G +C++C  G   L +  
Sbjct: 782 ENFYGLDVTN-CKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNN 840

Query: 442 ---CRPCSCDPSGSIDE---CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPC 495
              C PC+CD +G+I+    CN  TG+C CK  V G  C +C+P  +NL   N + C  C
Sbjct: 841 SFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMC 900

Query: 496 FC 497
            C
Sbjct: 901 EC 902



 Score =  119 bits (297), Expect = 3e-26
 Identities = 86/280 (30%), Positives = 116/280 (41%), Gaps = 38/280 (13%)

Query: 670  DVTLASARPGPGVPATWVESCTCPVGYGGQFCEMCLSG--YRRETPNLGPYSPCVLCACN 727
            D   A + PG    A     C C     G+ C  CL G  Y R+  +      C+ C C+
Sbjct: 796  DCDTAGSLPGTVCNAK-TGQCICKPNVEGRQCNKCLEGNFYLRQNNSF----LCLPCNCD 850

Query: 728  -----GHSETCDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCA 782
                   S  C+  TG C C+    G  C +C    Y + T      CQ C C    S  
Sbjct: 851  KTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRY-NLTIDNFQHCQMCEC---DSLG 906

Query: 783  VVPKTKEVVCTN------CPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDP 836
             +P T   +C        C     G+RC  C  G++  P    G    C  C C      
Sbjct: 907  TLPGT---ICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATG----CLPCSCHTTGAV 959

Query: 837  NAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQS 896
            N +  CN LTG+C+    + AG  CD+CKD +FG         +C+ CNC+L G + +  
Sbjct: 960  NHI--CNSLTGQCVCQDASIAGQRCDQCKDHYFG---FDPQTGRCQPCNCHLSGALNE-- 1012

Query: 897  SCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQ--GCER 934
            +C+ VTGQC C   VTG  C AC P   +L      GC +
Sbjct: 1013 TCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSK 1052



 Score =  117 bits (294), Expect = 7e-26
 Identities = 72/240 (30%), Positives = 112/240 (46%), Gaps = 42/240 (17%)

Query: 288 CNGHASEC-MKNEFDKLVCN-CKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCN 345
           CN H+ +C  K E   L C+ C+ N YG+D   C         +    ++A       CN
Sbjct: 759 CNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNC---------KACDCDTAGSLPGTVCN 809

Query: 346 GRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEA--CSSCHCSPV 403
            ++ +C                  C+ N +G  C +C E  F L  N +  C  C+C   
Sbjct: 810 AKTGQCI-----------------CKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKT 852

Query: 404 GSL--STQCD-SYGRCSCKPGVMGDKCDRCQPGFHSLTEAG---CRPCSCDPSGSIDE-- 455
           G++  S  C+ S G+C CK GV G +C++C+P  ++LT      C+ C CD  G++    
Sbjct: 853 GTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTI 912

Query: 456 CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSV---CTNAVGYSV 512
           C+  +G+C+C  N +G  C +C+PGF+ +   N  GC PC C    +V   C +  G  V
Sbjct: 913 CDPISGQCLCVPNRQGRRCNQCQPGFY-ISPGNATGCLPCSCHTTGAVNHICNSLTGQCV 971



 Score =  102 bits (254), Expect = 3e-21
 Identities = 62/198 (31%), Positives = 95/198 (47%), Gaps = 23/198 (11%)

Query: 305  CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCN--GRSQECYFDPELYRSTG 362
            C CK    G+ C +C P   +      T ++   C  C+C+  G       DP       
Sbjct: 868  CPCKLGVTGLRCNQCEPHRYN-----LTIDNFQHCQMCECDSLGTLPGTICDPI------ 916

Query: 363  HGGHCTNCQDNTDGAHCERCRENFF-RLGNNEACSSCHCSPVGSLSTQCDSY-GRCSCKP 420
              G C  C  N  G  C +C+  F+   GN   C  C C   G+++  C+S  G+C C+ 
Sbjct: 917  -SGQCL-CVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVNHICNSLTGQCVCQD 974

Query: 421  G-VMGDKCDRCQP---GFHSLTEAGCRPCSCDPSGSIDE-CNIETGRCVCKDNVEGFNCE 475
              + G +CD+C+    GF   T   C+PC+C  SG+++E C++ TG+C CK  V G  C+
Sbjct: 975  ASIAGQRCDQCKDHYFGFDPQT-GRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCD 1033

Query: 476  RCKPGFFNLESSNPRGCT 493
             C P   +L+ +N  GC+
Sbjct: 1034 ACVPSASHLDVNNLLGCS 1051



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 46/148 (31%), Positives = 62/148 (41%), Gaps = 16/148 (10%)

Query: 305  CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHG 364
            C C  N  G  C +C P F   P       +A+ CLPC C+      +    L       
Sbjct: 920  CLCVPNRQGRRCNQCQPGFYISPG------NATGCLPCSCHTTGAVNHICNSLT------ 967

Query: 365  GHCTNCQD-NTDGAHCERCRENFFRLGNNEA-CSSCHCSPVGSLSTQCDSY-GRCSCKPG 421
            G C  CQD +  G  C++C++++F        C  C+C   G+L+  C    G+C CK  
Sbjct: 968  GQCV-CQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQF 1026

Query: 422  VMGDKCDRCQPGFHSLTEAGCRPCSCDP 449
            V G KCD C P    L       CS  P
Sbjct: 1027 VTGSKCDACVPSASHLDVNNLLGCSKTP 1054



 Score = 36.6 bits (83), Expect = 0.20
 Identities = 21/67 (31%), Positives = 27/67 (40%), Gaps = 9/67 (13%)

Query: 447 CDPSGSIDECNIETG--RCVCKDN--VEGFNCERCKP-----GFFNLESSNPRGCTPCFC 497
           C   G  D C+  +   RC+C      EG +C+RC P      F   +      C PC C
Sbjct: 518 CQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQC 577

Query: 498 FGHSSVC 504
             HS  C
Sbjct: 578 NSHSKSC 584


>gi|219842259 usherin isoform A [Homo sapiens]
          Length = 1546

 Score =  245 bits (626), Expect = 2e-64
 Identities = 143/428 (33%), Positives = 227/428 (53%), Gaps = 37/428 (8%)

Query: 101 HGAAFLTDYNNQADTTWWQSQ-TMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPES 159
           H  +F+ D  N   T+W  +  T +  +    +I++ L  G+ + + Y+ ++F + +P  
Sbjct: 340 HPLSFVND--NDVGTSWVSNVFTNITQLNQGVTISVDLENGQ-YQVFYIIIQFFSPQPTE 396

Query: 160 FAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGN 219
             I ++      W  +QY++ +C   +   N G +    ++  ++   + S+ +P + GN
Sbjct: 397 IRIQRKKENSLDWEDWQYFARNC-GAFGMKNNGDL----EKPDSVNCLQLSNFTPYSRGN 451

Query: 220 VAFSTLEG----RPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYY 275
           V FS L      RP   NF N+P LQE+V AT IR   +      +   N    L+  YY
Sbjct: 452 VTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHFHGQYYTTETAVN----LRHRYY 507

Query: 276 AISDFAVGGRCKCNGHASEC-MKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAE 334
           A+ +  + GRC+C+GHA  C   ++  + +C+ +  T G+ C++CLP +ND+P+R+    
Sbjct: 508 AVDEITISGRCQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQV 567

Query: 335 SASECLPCDCNGRSQECYF----DPELYRS-TGHGGHCTNCQDNTDGAHCERCRENFFR- 388
            A  C PC CN  S+ C++    DP  +    G GG C +C+ NT G +CE C++ FFR 
Sbjct: 568 YAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQ 627

Query: 389 LGNN----EACSSCHCSPVGSL--STQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEA- 440
           +G +    + C  C C  VG+   S  CD   G+C+CK  V G +C++CQ GF++L E  
Sbjct: 628 VGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELD 687

Query: 441 --GCRPCSCDPSGSID---ECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPC 495
             GC PC+C+ SG++D    C+  +G+C CK NV G  C+ C  GF  L S N  GC PC
Sbjct: 688 PDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPC 747

Query: 496 FCFGHSSV 503
            C  H SV
Sbjct: 748 QCNLHGSV 755



 Score =  197 bits (500), Expect = 9e-50
 Identities = 114/356 (32%), Positives = 172/356 (48%), Gaps = 29/356 (8%)

Query: 690  CTCPVGYGGQFCEMCLSGYR--RETPNLGPYSPCVLCACNGHSET---CDPETGVCNCRD 744
            C C     G  C+ C  G++  R   ++G    C  C CN H      C+P +G C C+ 
Sbjct: 715  CKCKANVIGLRCDHCNFGFKFLRSFNDVG----CEPCQCNLHGSVNKFCNPHSGQCECKK 770

Query: 745  NTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCP-GGSSCAVVPKTKEVVCTNCPTGTTGKR 803
               G  C+ C + +YG       ++C+ C C   GS    V   K   C  C     G++
Sbjct: 771  EAKGLQCDTCRENFYGLDV----TNCKACDCDTAGSLPGTVCNAKTGQCI-CKPNVEGRQ 825

Query: 804  CELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDR 863
            C  C +G F   L +N    LC  C C      N    CN+ TG+C  C     G  C++
Sbjct: 826  CNKCLEGNFY--LRQNNSF-LCLPCNCDKTGTINGSLLCNKSTGQC-PCKLGVTGLRCNQ 881

Query: 864  CKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGF 923
            C+   +   L  +    C+ C C+  GT+   + C+P++GQC C+P+  G+ C  C PGF
Sbjct: 882  CEPHRYN--LTIDNFQHCQMCECDSLGTLPG-TICDPISGQCLCVPNRQGRRCNQCQPGF 938

Query: 924  Y-NLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPG-ITGQHCERCEVNHFGFGPEG-- 979
            Y +  +  GC  C CH  G+ N  C+  TGQC CQ   I GQ C++C+ ++FGF P+   
Sbjct: 939  YISPGNATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGR 998

Query: 980  CKPCDCHPEGSLSLQCK-DDGRCECREGFVGNRCDQC--EENYFYNRSWPGCQECP 1032
            C+PC+CH  G+L+  C    G+C C++   G++CD C    ++    +  GC + P
Sbjct: 999  CQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTP 1054



 Score =  192 bits (489), Expect = 2e-48
 Identities = 108/323 (33%), Positives = 159/323 (49%), Gaps = 26/323 (8%)

Query: 724  CACNGHSETCD----PETGVCNCRDNTAGPHCEKC----SDGYYGDSTAGTSSDCQPCPC 775
            C C+GH++ CD    P   +C+    T G HC++C    +D  +       + +C+PC C
Sbjct: 518  CQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQC 577

Query: 776  PGGS-SC----AVVPKTKEV------VCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRL 824
               S SC    +V P   E       VC +C   TTG+ CELC D +F         + +
Sbjct: 578  NSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDV 637

Query: 825  CRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKAC 884
            C+ C C      N    C+++ G+C  C  + +G  C++C++GF+   L     D C  C
Sbjct: 638  CKPCDCDTVGTRNGSILCDQIGGQC-NCKRHVSGRQCNQCQNGFYN--LQELDPDGCSPC 694

Query: 885  NCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQ--GCERCDCHALGS 942
            NCN  GT+    +C+  +GQC+C  +V G  C  C+ GF  L+S    GCE C C+  GS
Sbjct: 695  NCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGS 754

Query: 943  TNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSL--SLQCKDDGR 1000
             N  C+  +GQCEC+    G  C+ C  N +G     CK CDC   GSL  ++     G+
Sbjct: 755  VNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQ 814

Query: 1001 CECREGFVGNRCDQCEENYFYNR 1023
            C C+    G +C++C E  FY R
Sbjct: 815  CICKPNVEGRQCNKCLEGNFYLR 837



 Score =  187 bits (475), Expect = 7e-47
 Identities = 121/374 (32%), Positives = 169/374 (45%), Gaps = 56/374 (14%)

Query: 698  GQFCEMCLSGYRRETPNLGPYS---PCVLCACNGHSETC------DP--------ETGVC 740
            G  C+ CL  Y  +    G       C  C CN HS++C      DP          GVC
Sbjct: 546  GLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGGGVC 605

Query: 741  -NCRDNTAGPHCEKCSDGYYGDSTAGTSS--DCQPCPCPGGSSCAVVPKTKEVVC----- 792
             +C  NT G +CE C D ++    A  S+   C+PC C       V  +   ++C     
Sbjct: 606  DDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCD-----TVGTRNGSILCDQIGG 660

Query: 793  -TNCPTGTTGKRCELCDDGYFG----DPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTG 847
              NC    +G++C  C +G++     DP G       C  C C+ +   +    C++ +G
Sbjct: 661  QCNCKRHVSGRQCNQCQNGFYNLQELDPDG-------CSPCNCNTSGTVDGDITCHQNSG 713

Query: 848  ECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCEC 907
            +C KC  N  G  CD C  GF    L       C+ C CNL+G++ +   CNP +GQCEC
Sbjct: 714  QC-KCKANVIGLRCDHCNFGF--KFLRSFNDVGCEPCQCNLHGSVNK--FCNPHSGQCEC 768

Query: 908  LPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQ-CDIRTGQCECQPGITGQHCE 966
                 G  C  C   FY L     C+ CDC   GS  G  C+ +TGQC C+P + G+ C 
Sbjct: 769  KKEAKGLQCDTCRENFYGLDV-TNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCN 827

Query: 967  RCEVNHFGFGPEG---CKPCDCHPEGSL--SLQC-KDDGRCECREGFVGNRCDQCEENYF 1020
            +C   +F         C PC+C   G++  SL C K  G+C C+ G  G RC+QCE  + 
Sbjct: 828  KCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEP-HR 886

Query: 1021 YNRSWPGCQECPAC 1034
            YN +    Q C  C
Sbjct: 887  YNLTIDNFQHCQMC 900



 Score =  184 bits (467), Expect = 6e-46
 Identities = 117/359 (32%), Positives = 163/359 (45%), Gaps = 35/359 (9%)

Query: 690  CTCPVGYGGQFCEMCLSGYRRETPNLGPYSP--CVLCACNGHSE-----TCDPETGVCNC 742
            C C     G+ C  C +G+     NL    P  C  C CN         TC   +G C C
Sbjct: 662  CNCKRHVSGRQCNQCQNGFY----NLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKC 717

Query: 743  RDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGK 802
            + N  G  C+ C+ G+     +     C+PC C    S           C  C     G 
Sbjct: 718  KANVIGLRCDHCNFGFKF-LRSFNDVGCEPCQCNLHGSVNKFCNPHSGQC-ECKKEAKGL 775

Query: 803  RCELCDDGYFGDPLGRNGPVRLCRLCQCSDNID-PNAVGNCNRLTGECLKCIYNTAGFYC 861
            +C+ C + ++G        V  C+ C C      P  V  CN  TG+C+ C  N  G  C
Sbjct: 776  QCDTCRENFYGLD------VTNCKACDCDTAGSLPGTV--CNAKTGQCI-CKPNVEGRQC 826

Query: 862  DRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDP 921
            ++C +G F   L  N +  C  CNC+  GT+     CN  TGQC C   VTG  C  C+P
Sbjct: 827  NKCLEGNFY--LRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEP 884

Query: 922  GFYNL--QSGQGCERCDCHALGSTNGQ-CDIRTGQCECQPGITGQHCERCEVNHFGFGP- 977
              YNL   + Q C+ C+C +LG+  G  CD  +GQC C P   G+ C +C+   F   P 
Sbjct: 885  HRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPG-FYISPG 943

Query: 978  --EGCKPCDCHPEGSLSLQCKD-DGRCECREGFV-GNRCDQCEENYF-YNRSWPGCQEC 1031
               GC PC CH  G+++  C    G+C C++  + G RCDQC+++YF ++     CQ C
Sbjct: 944  NATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPC 1002



 Score =  127 bits (319), Expect = 9e-29
 Identities = 85/303 (28%), Positives = 127/303 (41%), Gaps = 90/303 (29%)

Query: 286 CKCNGHASECMKN------EFDKL-----VCN-CKHNTYGVDCEKCLPFFNDRPWRRATA 333
           C+CN H+  C  N       F+       VC+ C+HNT G +CE C  +F    +R+  A
Sbjct: 575 CQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYF----FRQVGA 630

Query: 334 ESAS--ECLPCDCN--GRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRL 389
           + ++   C PCDC+  G         ++      GG C NC+ +  G  C +C+  F+ L
Sbjct: 631 DPSAIDVCKPCDCDTVGTRNGSILCDQI------GGQC-NCKRHVSGRQCNQCQNGFYNL 683

Query: 390 G--NNEACSSCHCSPVGSLS---TQCDSYGRCSCKPGVMGDKCDRCQPGF---HSLTEAG 441
              + + CS C+C+  G++    T   + G+C CK  V+G +CD C  GF    S  + G
Sbjct: 684 QELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVG 743

Query: 442 CRPCSCDPSGSIDE---------------------------------------------- 455
           C PC C+  GS+++                                              
Sbjct: 744 CEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSL 803

Query: 456 ----CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFC-----FGHSSVCTN 506
               CN +TG+C+CK NVEG  C +C  G F L  +N   C PC C        S +C  
Sbjct: 804 PGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNK 863

Query: 507 AVG 509
           + G
Sbjct: 864 STG 866



 Score =  124 bits (311), Expect = 7e-28
 Identities = 78/242 (32%), Positives = 107/242 (44%), Gaps = 37/242 (15%)

Query: 274 YYAISDFAVGGRCKCNGHASECMKNEF----DKLVCNCKHNTYGVDCEKC------LPFF 323
           +Y + +    G   CN + S  +  +     +   C CK N  G+ C+ C      L  F
Sbjct: 680 FYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSF 739

Query: 324 NDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCR 383
           ND             C PC CN       F         H G C  C+    G  C+ CR
Sbjct: 740 ND-----------VGCEPCQCNLHGSVNKF------CNPHSGQC-ECKKEAKGLQCDTCR 781

Query: 384 ENFFRLGNNEACSSCHCSPVGSL-STQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEAG 441
           ENF+ L     C +C C   GSL  T C++  G+C CKP V G +C++C  G   L +  
Sbjct: 782 ENFYGLDVTN-CKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNN 840

Query: 442 ---CRPCSCDPSGSIDE---CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPC 495
              C PC+CD +G+I+    CN  TG+C CK  V G  C +C+P  +NL   N + C  C
Sbjct: 841 SFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMC 900

Query: 496 FC 497
            C
Sbjct: 901 EC 902



 Score =  119 bits (297), Expect = 3e-26
 Identities = 86/280 (30%), Positives = 116/280 (41%), Gaps = 38/280 (13%)

Query: 670  DVTLASARPGPGVPATWVESCTCPVGYGGQFCEMCLSG--YRRETPNLGPYSPCVLCACN 727
            D   A + PG    A     C C     G+ C  CL G  Y R+  +      C+ C C+
Sbjct: 796  DCDTAGSLPGTVCNAK-TGQCICKPNVEGRQCNKCLEGNFYLRQNNSF----LCLPCNCD 850

Query: 728  -----GHSETCDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCA 782
                   S  C+  TG C C+    G  C +C    Y + T      CQ C C    S  
Sbjct: 851  KTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRY-NLTIDNFQHCQMCEC---DSLG 906

Query: 783  VVPKTKEVVCTN------CPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDP 836
             +P T   +C        C     G+RC  C  G++  P    G    C  C C      
Sbjct: 907  TLPGT---ICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATG----CLPCSCHTTGAV 959

Query: 837  NAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQS 896
            N +  CN LTG+C+    + AG  CD+CKD +FG         +C+ CNC+L G + +  
Sbjct: 960  NHI--CNSLTGQCVCQDASIAGQRCDQCKDHYFG---FDPQTGRCQPCNCHLSGALNE-- 1012

Query: 897  SCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQ--GCER 934
            +C+ VTGQC C   VTG  C AC P   +L      GC +
Sbjct: 1013 TCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSK 1052



 Score =  117 bits (294), Expect = 7e-26
 Identities = 72/240 (30%), Positives = 112/240 (46%), Gaps = 42/240 (17%)

Query: 288 CNGHASEC-MKNEFDKLVCN-CKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCN 345
           CN H+ +C  K E   L C+ C+ N YG+D   C         +    ++A       CN
Sbjct: 759 CNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNC---------KACDCDTAGSLPGTVCN 809

Query: 346 GRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEA--CSSCHCSPV 403
            ++ +C                  C+ N +G  C +C E  F L  N +  C  C+C   
Sbjct: 810 AKTGQCI-----------------CKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKT 852

Query: 404 GSL--STQCD-SYGRCSCKPGVMGDKCDRCQPGFHSLTEAG---CRPCSCDPSGSIDE-- 455
           G++  S  C+ S G+C CK GV G +C++C+P  ++LT      C+ C CD  G++    
Sbjct: 853 GTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTI 912

Query: 456 CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSV---CTNAVGYSV 512
           C+  +G+C+C  N +G  C +C+PGF+ +   N  GC PC C    +V   C +  G  V
Sbjct: 913 CDPISGQCLCVPNRQGRRCNQCQPGFY-ISPGNATGCLPCSCHTTGAVNHICNSLTGQCV 971



 Score =  102 bits (254), Expect = 3e-21
 Identities = 62/198 (31%), Positives = 95/198 (47%), Gaps = 23/198 (11%)

Query: 305  CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCN--GRSQECYFDPELYRSTG 362
            C CK    G+ C +C P   +      T ++   C  C+C+  G       DP       
Sbjct: 868  CPCKLGVTGLRCNQCEPHRYN-----LTIDNFQHCQMCECDSLGTLPGTICDPI------ 916

Query: 363  HGGHCTNCQDNTDGAHCERCRENFF-RLGNNEACSSCHCSPVGSLSTQCDSY-GRCSCKP 420
              G C  C  N  G  C +C+  F+   GN   C  C C   G+++  C+S  G+C C+ 
Sbjct: 917  -SGQCL-CVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVNHICNSLTGQCVCQD 974

Query: 421  G-VMGDKCDRCQP---GFHSLTEAGCRPCSCDPSGSIDE-CNIETGRCVCKDNVEGFNCE 475
              + G +CD+C+    GF   T   C+PC+C  SG+++E C++ TG+C CK  V G  C+
Sbjct: 975  ASIAGQRCDQCKDHYFGFDPQT-GRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCD 1033

Query: 476  RCKPGFFNLESSNPRGCT 493
             C P   +L+ +N  GC+
Sbjct: 1034 ACVPSASHLDVNNLLGCS 1051



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 46/148 (31%), Positives = 62/148 (41%), Gaps = 16/148 (10%)

Query: 305  CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHG 364
            C C  N  G  C +C P F   P       +A+ CLPC C+      +    L       
Sbjct: 920  CLCVPNRQGRRCNQCQPGFYISPG------NATGCLPCSCHTTGAVNHICNSLT------ 967

Query: 365  GHCTNCQD-NTDGAHCERCRENFFRLGNNEA-CSSCHCSPVGSLSTQCDSY-GRCSCKPG 421
            G C  CQD +  G  C++C++++F        C  C+C   G+L+  C    G+C CK  
Sbjct: 968  GQCV-CQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQF 1026

Query: 422  VMGDKCDRCQPGFHSLTEAGCRPCSCDP 449
            V G KCD C P    L       CS  P
Sbjct: 1027 VTGSKCDACVPSASHLDVNNLLGCSKTP 1054



 Score = 36.6 bits (83), Expect = 0.20
 Identities = 21/67 (31%), Positives = 27/67 (40%), Gaps = 9/67 (13%)

Query: 447 CDPSGSIDECNIETG--RCVCKDN--VEGFNCERCKP-----GFFNLESSNPRGCTPCFC 497
           C   G  D C+  +   RC+C      EG +C+RC P      F   +      C PC C
Sbjct: 518 CQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQC 577

Query: 498 FGHSSVC 504
             HS  C
Sbjct: 578 NSHSKSC 584


>gi|93204871 netrin 4 [Homo sapiens]
          Length = 628

 Score =  245 bits (626), Expect = 2e-64
 Identities = 151/452 (33%), Positives = 220/452 (48%), Gaps = 59/452 (13%)

Query: 50  CMPEFVNAAFNVTVVATNTCGTPPEE-YCVQTGVTGVT---KSCHLCDAGQPHLQHGAAF 105
           C P   N A    + A  TCG    E YC  +  T +T     C  C+A  PHL H  + 
Sbjct: 34  CNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHLPSA 93

Query: 106 LTDYNNQADTTWWQSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKR 165
           + D + +   TWWQS       +      + L L   F  T++ + F + RP +  + + 
Sbjct: 94  MADSSFRFPRTWWQS------AEDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRS 147

Query: 166 TREDGPWIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTL 225
                 W PY+Y++ +C  T+   +   ++ G     A+CT ++S   P TGG V F  L
Sbjct: 148 QDFGKTWKPYKYFATNCSATFGLED-DVVKKG-----AICTSKYSSPFPCTGGEVIFKAL 201

Query: 226 EGRPSAYNFDN--SPVLQEWVTATDIRVTLNRLNTFG---DEVFNDPKVLKSYYYAISDF 280
                 Y+ +N  S  +QE +  T++RV L +  +     +++  +P+     +YAI DF
Sbjct: 202 S---PPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFT--HYAIYDF 256

Query: 281 AVGGRCKCNGHASECMKNEFDKLV------------CNCKHNTYGVDCEKCLPFFNDRPW 328
            V G C CNGHA +C+     + V            C CKHNT G  C+ C P +NDRPW
Sbjct: 257 IVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCMCKHNTAGSHCQHCAPLYNDRPW 316

Query: 329 RRATAESAS--ECLPCDCNGRSQECYFDPELYRSTGH--GGHCTNCQDNTDGAHCERCRE 384
             A  ++ +  EC  C CNG +  C+FD  ++ ++G+  GG C +CQ NT+G +C+RC+ 
Sbjct: 317 EAADGKTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKP 376

Query: 385 NFFR-----LGNNEACSSCHCSPVGSLS------TQCD-SYGRCSCKPGVMGDKCDRCQP 432
            F+R         +AC  C C PVGS        T CD S G C CKPGV G +CDRC  
Sbjct: 377 GFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMV 436

Query: 433 GFHSLTEAGCRPCSCDPSGSIDECNIETGRCV 464
           G+    + GCRPC C  S     C+  TG C+
Sbjct: 437 GYWGFGDYGCRPCDCAGS-----CDPITGDCI 463



 Score =  108 bits (270), Expect = 4e-23
 Identities = 73/249 (29%), Positives = 103/249 (41%), Gaps = 69/249 (27%)

Query: 838  AVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPL--------APNPADKCKACNCNLY 889
            A G  + + G+C+ C +NTAG +C  C   +   P         APN   +C+ C CN +
Sbjct: 282  APGTFHMVHGKCM-CKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPN---ECRTCKCNGH 337

Query: 890  GTMKQ------QSSCNPVTGQCECLPHVT-GQDCGACDPGFYN-----LQSGQGCERCDC 937
                       ++S N   G C+   H T GQ C  C PGFY        +   C+ C C
Sbjct: 338  ADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSC 397

Query: 938  HALGST----NGQ--CDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDC------ 985
            H +GS     N    CD   G C C+PG+ G+ C+RC V ++GFG  GC+PCDC      
Sbjct: 398  HPVGSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMVGYWGFGDYGCRPCDCAGSCDP 457

Query: 986  ------------------------HPEGSLSLQCKD---------DGRCECREGFVGNRC 1012
                                    H +   + + +D          G+CEC+E  +GN  
Sbjct: 458  ITGDCISSHTDIDWYHEVPDFRPVHNKSEPAWEWEDAQGFSALLHSGKCECKEQTLGNAK 517

Query: 1013 DQCEENYFY 1021
              C   Y Y
Sbjct: 518  AFCGMKYSY 526



 Score = 94.7 bits (234), Expect = 6e-19
 Identities = 102/405 (25%), Positives = 157/405 (38%), Gaps = 83/405 (20%)

Query: 724  CACNGHSETCDPETGV---------------CNCRDNTAGPHCEKCSDGY------YGDS 762
            C CNGH++ C P  G                C C+ NTAG HC+ C+  Y        D 
Sbjct: 262  CFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADG 321

Query: 763  TAGTSSDCQPCPCPG-GSSCAVVPKTKEV-------VCTNCPTGTTGKRCELCDDGYFGD 814
              G  ++C+ C C G   +C       E        VC +C   T G+ C+ C  G++ D
Sbjct: 322  KTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPGFYRD 381

Query: 815  PLGRNGPVRLCRLCQC----SDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFG 870
                      C+ C C    S  +  N+V  C+   G+C  C    AG  CDRC  G++G
Sbjct: 382  LRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDC-PCKPGVAGRRCDRCMVGYWG 440

Query: 871  NPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGF--YNLQS 928
                      C+ C+C          SC+P+TG  +C+   T  D     P F   + +S
Sbjct: 441  -----FGDYGCRPCDC--------AGSCDPITG--DCISSHTDIDWYHEVPDFRPVHNKS 485

Query: 929  GQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPE 988
                E  D     +      + +G+CEC+    G     C + +        K    H +
Sbjct: 486  EPAWEWEDAQGFSAL-----LHSGKCECKEQTLGNAKAFCGMKYSYV--LKIKILSAHDK 538

Query: 989  GS---LSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWP--GCQECPACYRLVKDKVA 1043
            G+   ++++ K   +    + F G R         Y  SW   GC  CP     ++  VA
Sbjct: 539  GTHVEVNVKIKKVLKSTKLKIFRGKRT-------LYPESWTDRGC-TCPILNPGLEYLVA 590

Query: 1044 DHRVKLQELESLIANLGTGDEMVTDQAFEDRLKEA-EREVMDLLR 1087
             H            ++ TG  +V  ++F    K +  R+VMD+L+
Sbjct: 591  GHE-----------DIRTGKLIVNMKSFVQHWKPSLGRKVMDILK 624



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 59/187 (31%), Positives = 82/187 (43%), Gaps = 42/187 (22%)

Query: 690 CTCPVGYGGQFCEMCLSGYRRET-----PNLGPYSPCVLCACNGHSETC----------- 733
           C C     G  C+ C   Y            G  + C  C CNGH++TC           
Sbjct: 293 CMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEASG 352

Query: 734 DPETGVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSSD--CQPCPC-PGGSSCAVVPKTKE 789
           +   GVC +C+ NT G +C++C  G+Y D     S+   C+PC C P GS  AV+P    
Sbjct: 353 NRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGS--AVLPANSV 410

Query: 790 VVC------TNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCN 843
             C        C  G  G+RC+ C  GY+G   G  G    CR C C+        G+C+
Sbjct: 411 TFCDPSNGDCPCKPGVAGRRCDRCMVGYWG--FGDYG----CRPCDCA--------GSCD 456

Query: 844 RLTGECL 850
            +TG+C+
Sbjct: 457 PITGDCI 463



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 73/244 (29%), Positives = 95/244 (38%), Gaps = 59/244 (24%)

Query: 342 CDCNGRSQECY----FDPELYRSTGH--GGHCTNCQDNTDGAHCERCRENFF-------- 387
           C CNG + +C     F P     T H   G C  C+ NT G+HC+ C   +         
Sbjct: 262 CFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCM-CKHNTAGSHCQHCAPLYNDRPWEAAD 320

Query: 388 -RLGNNEACSSCHCSPVGSL---------STQCDSYGRCS-CKPGVMGDKCDRCQPGFH- 435
            + G    C +C C+              ++   S G C  C+    G  C RC+PGF+ 
Sbjct: 321 GKTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPGFYR 380

Query: 436 ------SLTEAGCRPCSCDPSGS-------IDECNIETGRCVCKDNVEGFNCERCKPGFF 482
                 S  +A C+PCSC P GS       +  C+   G C CK  V G  C+RC  G++
Sbjct: 381 DLRRPFSAPDA-CKPCSCHPVGSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMVGYW 439

Query: 483 NLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAEQRD------GSEA 536
                   GC PC C G     T         ISS   ID   W  E  D       SE 
Sbjct: 440 GF---GDYGCRPCDCAGSCDPITGD------CISSHTDID---WYHEVPDFRPVHNKSEP 487

Query: 537 SLEW 540
           + EW
Sbjct: 488 AWEW 491


>gi|164414431 netrin G1 isoform 1 [Homo sapiens]
          Length = 539

 Score =  224 bits (572), Expect = 4e-58
 Identities = 144/451 (31%), Positives = 206/451 (45%), Gaps = 60/451 (13%)

Query: 68  TCGTPPEEYCVQTGVTGVTKSCHL-CDAGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAG 126
           TCG PPE +C      G    C+  CDA  P L H    + D+  +  +T+WQS T    
Sbjct: 71  TCGDPPETFCAM----GNPYMCNNECDASTPELAHPPELMFDFEGRHPSTFWQSATWK-- 124

Query: 127 VQYPS--SINLTLHLGKAFDIT-YVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCE 183
            +YP    +N+TL   K  ++T  + + F + RP+   + K       W PYQYY+  C 
Sbjct: 125 -EYPKPLQVNITLSWSKTIELTDNIVITFESGRPDQMILEKSLDYGRTWQPYQYYATDCL 183

Query: 184 NTYSKANRGFIRTGGDEQ-QALCTDEFSDISPLTGGNVAFST-----------LEGRPSA 231
           + +    +           + +CT+E+S         + F             L    S 
Sbjct: 184 DAFHMDPKSVKDLSQHTVLEIICTEEYSTGYTTNSKIIHFEIKDRFAFFAGPRLRNMASL 243

Query: 232 YN-FDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNG 290
           Y   D +  L+++ T TD+R+ L  L     E+F D   L  Y+YAISD  V GRCKCN 
Sbjct: 244 YGQLDTTKKLRDFFTVTDLRIRL--LRPAVGEIFVDELHLARYFYAISDIKVRGRCKCNL 301

Query: 291 HASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRAT-----AESASECLP---- 341
           HA+ C+ +   KL C C+HNT G DC KC   +  RPW   +       +A+ C+P    
Sbjct: 302 HATVCVYDN-SKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPSISS 360

Query: 342 ---CDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFR-----LGNNE 393
              C+C G S  C +   L         C +C+ NT G HCE CR  +FR     L +  
Sbjct: 361 IGNCECFGHSNRCSYIDLLNTVI-----CVSCKHNTRGQHCELCRLGYFRNASAQLDDEN 415

Query: 394 ACSSCHCSPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCD----- 448
            C  C+C+P+GS+  +C+  G C CK G  G KCD C PG  +    GC+P  CD     
Sbjct: 416 VCIECYCNPLGSIHDRCNGSGFCECKTGTTGPKCDECLPG--NSWHYGCQPNVCDNELLH 473

Query: 449 -PSGSIDECNIETGRCVCKDNVEGFNCERCK 478
             +G     N+   RC+C     G  CE+ +
Sbjct: 474 CQNGGTCHNNV---RCLCPAAYTGILCEKLR 501



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 72/236 (30%), Positives = 93/236 (39%), Gaps = 45/236 (19%)

Query: 724 CACNGHSETC--DPETGVCNCRDNTAGPHCEKCSDGYYGDSTA---------GTSSDCQP 772
           C CN H+  C  D     C C  NT GP C KC   Y G   +         GT++ C P
Sbjct: 297 CKCNLHATVCVYDNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIP 356

Query: 773 -------CPCPGGSS-CAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRL 824
                  C C G S+ C+ +     V+C +C   T G+ CELC  GYF +   +     +
Sbjct: 357 SISSIGNCECFGHSNRCSYIDLLNTVICVSCKHNTRGQHCELCRLGYFRNASAQLDDENV 416

Query: 825 CRLCQCSDNIDPNAVGN----CNRLTGECLKCIYNTAGFYCDRCKDG-FFGNPLAPNPAD 879
           C  C C      N +G+    CN  +G C +C   T G  CD C  G  +     PN  D
Sbjct: 417 CIECYC------NPLGSIHDRCNG-SGFC-ECKTGTTGPKCDECLPGNSWHYGCQPNVCD 468

Query: 880 KCKACNCNLYGTMKQQSSC---NPVTG-QCECLPHVTGQDCGACDPGFYNLQSGQG 931
             +  +C   GT      C      TG  CE L       CG+         SGQG
Sbjct: 469 N-ELLHCQNGGTCHNNVRCLCPAAYTGILCEKLRCEEAGSCGS--------DSGQG 515



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 67/217 (30%), Positives = 90/217 (41%), Gaps = 30/217 (13%)

Query: 773 CPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPL--GRNGPVRLCRLCQC 830
           C C   ++  V   +K  +   C   TTG  C  C   Y G P   G   P+       C
Sbjct: 297 CKCNLHATVCVYDNSK--LTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTC 354

Query: 831 SDNIDPNAVGNC------NRL-------TGECLKCIYNTAGFYCDRCKDGFFGNPLAP-N 876
             +I  +++GNC      NR        T  C+ C +NT G +C+ C+ G+F N  A  +
Sbjct: 355 IPSI--SSIGNCECFGHSNRCSYIDLLNTVICVSCKHNTRGQHCELCRLGYFRNASAQLD 412

Query: 877 PADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCER-- 934
             + C  C CN  G++  +  CN  +G CEC    TG  C  C PG        GC+   
Sbjct: 413 DENVCIECYCNPLGSIHDR--CNG-SGFCECKTGTTGPKCDECLPGN---SWHYGCQPNV 466

Query: 935 CDCHALGSTNGQCDIRTGQCECQPGITGQHCE--RCE 969
           CD   L   NG       +C C    TG  CE  RCE
Sbjct: 467 CDNELLHCQNGGTCHNNVRCLCPAAYTGILCEKLRCE 503



 Score = 74.7 bits (182), Expect = 7e-13
 Identities = 52/174 (29%), Positives = 69/174 (39%), Gaps = 35/174 (20%)

Query: 884  CNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGAC---------DPGFYN--------- 925
            C CNL+ T+    +       CEC  + TG DCG C          PG Y          
Sbjct: 297  CKCNLHATVCVYDNSKLT---CECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANT 353

Query: 926  -LQSGQGCERCDCHALGSTNGQCDI-RTGQC-ECQPGITGQHCERCEVNHFGFGPEG--- 979
             + S      C+C    +     D+  T  C  C+    GQHCE C + +F         
Sbjct: 354  CIPSISSIGNCECFGHSNRCSYIDLLNTVICVSCKHNTRGQHCELCRLGYFRNASAQLDD 413

Query: 980  ---CKPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWP-GCQ 1029
               C  C C+P GS+  +C   G CEC+ G  G +CD+C        SW  GCQ
Sbjct: 414  ENVCIECYCNPLGSIHDRCNGSGFCECKTGTTGPKCDEC----LPGNSWHYGCQ 463



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 55/196 (28%), Positives = 75/196 (38%), Gaps = 47/196 (23%)

Query: 342 CDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCS 401
           C CN  +  C +D        +      C+ NT G  C +C++N+   G   +  S    
Sbjct: 297 CKCNLHATVCVYD--------NSKLTCECEHNTTGPDCGKCKKNY--QGRPWSPGSYLPI 346

Query: 402 PVGSLST---------QCDSYG---RCS------------CKPGVMGDKCDRCQPGFHSL 437
           P G+ +T          C+ +G   RCS            CK    G  C+ C+ G+   
Sbjct: 347 PKGTANTCIPSISSIGNCECFGHSNRCSYIDLLNTVICVSCKHNTRGQHCELCRLGYFRN 406

Query: 438 TEAG------CRPCSCDPSGSI-DECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPR 490
             A       C  C C+P GSI D CN  +G C CK    G  C+ C PG     +S   
Sbjct: 407 ASAQLDDENVCIECYCNPLGSIHDRCN-GSGFCECKTGTTGPKCDECLPG-----NSWHY 460

Query: 491 GCTPCFCFGHSSVCTN 506
           GC P  C      C N
Sbjct: 461 GCQPNVCDNELLHCQN 476



 Score = 61.2 bits (147), Expect = 8e-09
 Identities = 57/211 (27%), Positives = 84/211 (39%), Gaps = 53/211 (25%)

Query: 689 SCTCPVGYGGQFCEMCLSGYRRETPNLGPYSP--------CV-------LCACNGHSETC 733
           +C C     G  C  C   Y+    + G Y P        C+        C C GHS  C
Sbjct: 314 TCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPSISSIGNCECFGHSNRC 373

Query: 734 D----PETGVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSSD--CQPCPC-PGGSSCAVVP 785
                  T +C +C+ NT G HCE C  GY+ +++A    +  C  C C P GS   +  
Sbjct: 374 SYIDLLNTVICVSCKHNTRGQHCELCRLGYFRNASAQLDDENVCIECYCNPLGS---IHD 430

Query: 786 KTKEVVCTNCPTGTTGKRCELCDDG---YFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNC 842
           +        C TGTTG +C+ C  G   ++G                C  N+  N + +C
Sbjct: 431 RCNGSGFCECKTGTTGPKCDECLPGNSWHYG----------------CQPNVCDNELLHC 474

Query: 843 NRLTGEC---LKCIYNTA--GFYCD--RCKD 866
               G C   ++C+   A  G  C+  RC++
Sbjct: 475 QN-GGTCHNNVRCLCPAAYTGILCEKLRCEE 504



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 45/147 (30%), Positives = 59/147 (40%), Gaps = 31/147 (21%)

Query: 691 TCPVGYGGQFCEMCLSGY-RRETPNLGPYSPCVLCACNGHSETCD--PETGVCNCRDNTA 747
           +C     GQ CE+C  GY R  +  L   + C+ C CN      D    +G C C+  T 
Sbjct: 386 SCKHNTRGQHCELCRLGYFRNASAQLDDENVCIECYCNPLGSIHDRCNGSGFCECKTGTT 445

Query: 748 GPHCEKCSDG---YYGDSTAGTSSDCQP-------CPCPGGSSCAVVPKTKEVVCTNCPT 797
           GP C++C  G   +YG         CQP         C  G +C        V C  CP 
Sbjct: 446 GPKCDECLPGNSWHYG---------CQPNVCDNELLHCQNGGTC-----HNNVRCL-CPA 490

Query: 798 GTTGKRCE--LCDD-GYFGDPLGRNGP 821
             TG  CE   C++ G  G   G+  P
Sbjct: 491 AYTGILCEKLRCEEAGSCGSDSGQGAP 517


>gi|190014607 netrin G2 [Homo sapiens]
          Length = 530

 Score =  209 bits (531), Expect = 2e-53
 Identities = 151/482 (31%), Positives = 207/482 (42%), Gaps = 59/482 (12%)

Query: 41  TDEGGRPQ--RCMPEFVNAAFNVTVVATN---TCGTPPEEYCVQTGVTGVTKSCHLCDAG 95
           TDEG   +   C P+ +     V V       TCG PPE +C        +  C   DA 
Sbjct: 28  TDEGPTWEFYACQPKVMRLKDYVKVKVEPSGITCGDPPERFCSHENPYLCSNEC---DAS 84

Query: 96  QPHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQYPSSI--NLTLHLGKAFDITY-VRLKF 152
            P L H    + D   +   T+WQS T     +YPS +  N+TL   K  ++T  V + F
Sbjct: 85  NPDLAHPPRLMFDKEEEGLATYWQSITWS---RYPSPLEANITLSWNKTVELTDDVVMTF 141

Query: 153 HTSRPESFAIYKRTREDGPWIPYQYYSGSCENTYS-KANRGFIRTGGDEQQALCTDEFSD 211
              RP    + K       W PYQ+Y+  C   +   A R    +     + LCT+E+S 
Sbjct: 142 EYGRPTVMVLEKSLDNGRTWQPYQFYAEDCMEAFGMSARRARDMSSSSAHRVLCTEEYSR 201

Query: 212 -ISPLTGGNVAFSTLE-----GRPSAYNFDN-------SPVLQEWVTATDIRVTLNRLNT 258
                   +V F   +       P   N DN       +  L+E+ T TD+R+ L R   
Sbjct: 202 WAGSKKEKHVRFEVRDRFAIFAGPDLRNMDNLYTRLESAKGLKEFFTLTDLRMRLLRPAL 261

Query: 259 FGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEFDKLVCNCKHNTYGVDCEK 318
            G  V  +   L  Y+YAIS+  V GRCKCN HA+ C   E   L C C+HNT G DC K
Sbjct: 262 GGTYVQREN--LYKYFYAISNIEVIGRCKCNLHANLCSMRE-GSLQCECEHNTTGPDCGK 318

Query: 319 CLPFFNDRPWRRAT-----------AESASECLPCDCNGRSQECYFDPELYRSTGHGGHC 367
           C   F  R WR  +             +A     C+C G S  C +   L   T     C
Sbjct: 319 CKKNFRTRSWRAGSYLPLPHGSPNACATAGSFGNCECYGHSNRCSYIDFLNVVT-----C 373

Query: 368 TNCQDNTDGAHCERCRENFFRLGNNE-----ACSSCHCSPVGSLSTQCDSYGRCSCKPGV 422
            +C+ NT G HC+ CR  ++R G+ E      C  C+C+ +GS+  +C+  G C C+ G 
Sbjct: 374 VSCKHNTRGQHCQHCRLGYYRNGSAELDDENVCIECNCNQIGSVHDRCNETGFCECREGA 433

Query: 423 MGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECN---IETGRCVCKDNVEGFNCE--RC 477
            G KCD C P  +     GC P  CD    + +     ++  RC C     G  CE  RC
Sbjct: 434 AGPKCDDCLPTHY--WRQGCYPNVCDDDQLLCQNGGTCLQNQRCACPRGYTGVRCEQPRC 491

Query: 478 KP 479
            P
Sbjct: 492 DP 493



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 76/254 (29%), Positives = 100/254 (39%), Gaps = 56/254 (22%)

Query: 724 CACNGHSETCDPETGV--CNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSC 781
           C CN H+  C    G   C C  NT GP C KC   +   S    S      P P GS  
Sbjct: 287 CKCNLHANLCSMREGSLQCECEHNTTGPDCGKCKKNFRTRSWRAGSY----LPLPHGSPN 342

Query: 782 AVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDP-NAVG 840
           A            C T            G FG+             C+C  + +  + + 
Sbjct: 343 A------------CATA-----------GSFGN-------------CECYGHSNRCSYID 366

Query: 841 NCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAP-NPADKCKACNCNLYGTMKQQSSCN 899
             N +T  C+ C +NT G +C  C+ G++ N  A  +  + C  CNCN  G++  +  CN
Sbjct: 367 FLNVVT--CVSCKHNTRGQHCQHCRLGYYRNGSAELDDENVCIECNCNQIGSVHDR--CN 422

Query: 900 PVTGQCECLPHVTGQDCGACDPGFYNLQSGQGC--ERCDCHALGSTNGQCDIRTGQCECQ 957
             TG CEC     G  C  C P  Y     QGC    CD   L   NG   ++  +C C 
Sbjct: 423 E-TGFCECREGAAGPKCDDCLPTHY---WRQGCYPNVCDDDQLLCQNGGTCLQNQRCACP 478

Query: 958 PGITGQHCE--RCE 969
            G TG  CE  RC+
Sbjct: 479 RGYTGVRCEQPRCD 492



 Score = 84.7 bits (208), Expect = 6e-16
 Identities = 61/209 (29%), Positives = 85/209 (40%), Gaps = 29/209 (13%)

Query: 829  QCSDNIDPNAVGNCNRLTGEC-LKCIYNTAGFYCDRCKDGFF-----GNPLAPNPADKCK 882
            +C  N+  N    C+   G    +C +NT G  C +CK  F           P P     
Sbjct: 286  RCKCNLHANL---CSMREGSLQCECEHNTTGPDCGKCKKNFRTRSWRAGSYLPLPHGSPN 342

Query: 883  AC-------NCNLYGTMKQQSSCN--PVTGQCECLPHVTGQDCGACDPGFYN-----LQS 928
            AC       NC  YG   + S  +   V     C  +  GQ C  C  G+Y      L  
Sbjct: 343  ACATAGSFGNCECYGHSNRCSYIDFLNVVTCVSCKHNTRGQHCQHCRLGYYRNGSAELDD 402

Query: 929  GQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPE 988
               C  C+C+ +GS + +C+  TG CEC+ G  G  C+ C   H+    +GC P  C  +
Sbjct: 403  ENVCIECNCNQIGSVHDRCN-ETGFCECREGAAGPKCDDCLPTHYW--RQGCYPNVCDDD 459

Query: 989  GSLSLQ---CKDDGRCECREGFVGNRCDQ 1014
              L      C  + RC C  G+ G RC+Q
Sbjct: 460  QLLCQNGGTCLQNQRCACPRGYTGVRCEQ 488



 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 49/173 (28%), Positives = 72/173 (41%), Gaps = 36/173 (20%)

Query: 884  CNCNLYGTMKQQSSCNPVTG--QCECLPHVTGQDCGACDPGFYNLQ------------SG 929
            C CNL+  +     C+   G  QCEC  + TG DCG C   F                S 
Sbjct: 287  CKCNLHANL-----CSMREGSLQCECEHNTTGPDCGKCKKNFRTRSWRAGSYLPLPHGSP 341

Query: 930  QGCE------RCDCHALGSTNGQCD-IRTGQC-ECQPGITGQHCERCEVNHFGFGPEG-- 979
              C        C+C+   +     D +    C  C+    GQHC+ C + ++  G     
Sbjct: 342  NACATAGSFGNCECYGHSNRCSYIDFLNVVTCVSCKHNTRGQHCQHCRLGYYRNGSAELD 401

Query: 980  ----CKPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPGC 1028
                C  C+C+  GS+  +C + G CECREG  G +CD C   +++ +   GC
Sbjct: 402  DENVCIECNCNQIGSVHDRCNETGFCECREGAAGPKCDDCLPTHYWRQ---GC 451



 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 56/194 (28%), Positives = 77/194 (39%), Gaps = 44/194 (22%)

Query: 342 CDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENF----FRLGNNEAC-- 395
           C CN  +  C        S   G     C+ NT G  C +C++NF    +R G+      
Sbjct: 287 CKCNLHANLC--------SMREGSLQCECEHNTTGPDCGKCKKNFRTRSWRAGSYLPLPH 338

Query: 396 -SSCHCSPVGSLSTQCDSYG---RCS------------CKPGVMGDKCDRCQPGFHSLTE 439
            S   C+  GS    C+ YG   RCS            CK    G  C  C+ G++    
Sbjct: 339 GSPNACATAGSFGN-CECYGHSNRCSYIDFLNVVTCVSCKHNTRGQHCQHCRLGYYRNGS 397

Query: 440 AG------CRPCSCDPSGSI-DECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGC 492
           A       C  C+C+  GS+ D CN ETG C C++   G  C+ C P  +  +     GC
Sbjct: 398 AELDDENVCIECNCNQIGSVHDRCN-ETGFCECREGAAGPKCDDCLPTHYWRQ-----GC 451

Query: 493 TPCFCFGHSSVCTN 506
            P  C     +C N
Sbjct: 452 YPNVCDDDQLLCQN 465



 Score = 61.2 bits (147), Expect = 8e-09
 Identities = 39/123 (31%), Positives = 49/123 (39%), Gaps = 10/123 (8%)

Query: 687 VESCTCPVGYGGQFCEMCLSGYRRE-TPNLGPYSPCVLCACNGHSETCDP--ETGVCNCR 743
           V   +C     GQ C+ C  GY R  +  L   + C+ C CN      D   ETG C CR
Sbjct: 371 VTCVSCKHNTRGQHCQHCRLGYYRNGSAELDDENVCIECNCNQIGSVHDRCNETGFCECR 430

Query: 744 DNTAGPHCEKC-SDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGK 802
           +  AGP C+ C    Y+         D     C  G +C    +        CP G TG 
Sbjct: 431 EGAAGPKCDDCLPTHYWRQGCYPNVCDDDQLLCQNGGTCLQNQRCA------CPRGYTGV 484

Query: 803 RCE 805
           RCE
Sbjct: 485 RCE 487



 Score = 54.7 bits (130), Expect = 7e-07
 Identities = 38/139 (27%), Positives = 50/139 (35%), Gaps = 23/139 (16%)

Query: 690 CTCPVGYGGQFCEMCLSGYRRETPNLGPYSP--------CVL------CACNGHSETCDP 735
           C C     G  C  C   +R  +   G Y P        C        C C GHS  C  
Sbjct: 305 CECEHNTTGPDCGKCKKNFRTRSWRAGSYLPLPHGSPNACATAGSFGNCECYGHSNRCSY 364

Query: 736 ----ETGVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSSD--CQPCPCPGGSSCAVVPKTK 788
                   C +C+ NT G HC+ C  GYY + +A    +  C  C C      +V  +  
Sbjct: 365 IDFLNVVTCVSCKHNTRGQHCQHCRLGYYRNGSAELDDENVCIECNC--NQIGSVHDRCN 422

Query: 789 EVVCTNCPTGTTGKRCELC 807
           E     C  G  G +C+ C
Sbjct: 423 ETGFCECREGAAGPKCDDC 441


>gi|157419124 laminin, alpha 4 isoform 1 precursor [Homo sapiens]
          Length = 1823

 Score =  157 bits (397), Expect = 8e-38
 Identities = 86/216 (39%), Positives = 110/216 (50%), Gaps = 24/216 (11%)

Query: 721 CVLCACNGHSETCDPETGVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCP--- 776
           CV C CNG+S  C   +G C +C+ NT G HCEKC DGY GDS  G    CQPCPCP   
Sbjct: 79  CVPCDCNGNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAPQFCQPCPCPLPH 138

Query: 777 -GGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNID 835
               + +   K   V C  C     G  CE C  GY+G+PL        C+ C CS N D
Sbjct: 139 LANFAESCYRKNGAVRCI-CNENYAGPNCERCAPGYYGNPLLIGS---TCKKCDCSGNSD 194

Query: 836 PNAV-GNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQ 894
           PN +  +C+ +TG+C  C+ NT GF C+RC  G++G+      A  C  CNC        
Sbjct: 195 PNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYGD---ARIAKNCAVCNCG------- 244

Query: 895 QSSCNPVTGQC--ECLPHVTGQDCG--ACDPGFYNL 926
              C+ VTG+C  E     TG DC   +CD   ++L
Sbjct: 245 GGPCDSVTGECLEEGFEPPTGMDCPTISCDKCVWDL 280



 Score =  155 bits (392), Expect = 3e-37
 Identities = 187/837 (22%), Positives = 329/837 (39%), Gaps = 132/837 (15%)

Query: 735  PETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTN 794
            PET           P  EKC+ G++       S +C PC C G S+  +        C +
Sbjct: 48   PETSEPRVALGRLPPAAEKCNAGFFHT----LSGECVPCDCNGNSNECL---DGSGYCVH 100

Query: 795  CPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTG--ECLKC 852
            C   TTG+ CE C DGY GD +   G  + C+ C C      N   +C R  G   C+ C
Sbjct: 101  CQRNTTGEHCEKCLDGYIGDSI--RGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCI-C 157

Query: 853  IYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQ---SSCNPVTGQC-ECL 908
              N AG  C+RC  G++GNPL       CK C+C+  G          C+ VTGQC  CL
Sbjct: 158  NENYAGPNCERCAPGYYGNPLL--IGSTCKKCDCS--GNSDPNLIFEDCDEVTGQCRNCL 213

Query: 909  PHVTGQDCGACDPGFY-NLQSGQGCERCDCHALGSTNGQCDIRTGQC--ECQPGITGQHC 965
             + TG  C  C PG+Y + +  + C  C+C       G CD  TG+C  E     TG  C
Sbjct: 214  RNTTGFKCERCAPGYYGDARIAKNCAVCNC-----GGGPCDSVTGECLEEGFEPPTGMDC 268

Query: 966  ERCEVNHFGFGPEGCKPC-----DCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYF 1020
                          C  C     D     +LS++    G      G   +R         
Sbjct: 269  PTI----------SCDKCVWDLTDALRLAALSIEEGKSGVLSVSSGAAAHR--------- 309

Query: 1021 YNRSWPGCQECPACYRLVKDKVAD-------HRVKLQELESLIANLGTGDEMVTDQAFED 1073
                     E  A   L+K K+++        ++++   E+ + +L +  E + ++  + 
Sbjct: 310  ------HVNEINATIYLLKTKLSERENQYALRKIQINNAENTMKSLLSDVEELVEKENQA 363

Query: 1074 RLKE--AEREVMDLLREAQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGNLA 1131
              K    ++E MD +  A  + +   ++ D++Q +NN +       +     I E   LA
Sbjct: 364  SRKGQLVQKESMDTINHASQLVEQAHDMRDKIQEINNKMLYYGEEHELSPKEISEKLVLA 423

Query: 1132 EQARAHVENTERLIEIASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHK 1191
            ++    + + +       REL   +   A   ++Q ES         L  E R L     
Sbjct: 424  QKMLEEIRSRQPF--FTQRELVDEEADEAYELLSQAES------WQRLHNETRTLFPVVL 475

Query: 1192 QEADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAA 1251
            ++ DD         +   +A N +            + E++NR     +   +D EKQ  
Sbjct: 476  EQLDDYNAKLSDLQEALDQALNYVR-----------DAEDMNRATAARQ---RDHEKQQE 521

Query: 1252 RVHEEAK----RAGDKAVEIYASVAQLSPLDSETLENEANNIKMEAENLEQLIDQKLKDY 1307
            RV E+ +         A  +      LS LD   +   A+ I  E +  +  +  KL + 
Sbjct: 522  RVREQMEVVNMSLSTSADSLTTPRLTLSELDD--IIKNASGIYAEIDGAKSELQVKLSNL 579

Query: 1308 EDLREDMRGKELEVKNLLEKGKTEQQTADQLLARADAA-------KAL------------ 1348
             +L  D+      V+  ++  +  QQ A++L  +  ++       KAL            
Sbjct: 580  SNLSHDL------VQEAIDHAQDLQQEANELSRKLHSSDMNGLVQKALDASNVYENIVNY 633

Query: 1349 AEEAAKKGRDTLQEANDILNNLKDFDRRVNDNKTAAEEALRKIPAIN-QTITEANEKTRE 1407
              EA +     L   + I + +   D ++  +K  +E  L +   +  +  + ++E   +
Sbjct: 634  VSEANETAEFALNTTDRIYDAVSGIDTQIIYHKDESENLLNQARELQAKAESSSDEAVAD 693

Query: 1408 AQQALGSAAADATEAKNKAHEAERIASAVQKNATSTKAEAERTFAEVTDLDNEVNNMLKQ 1467
              + +G A A  +  K       R++ AV++   + + +A++   +   +  E N    +
Sbjct: 694  TSRRVGGALARKSALKT------RLSDAVKQLQAAERGDAQQRLGQSRLITEEANRTTME 747

Query: 1468 LQEAEKELKRKQDDADQDMMMAGMASQAAQEAEINARKAKNSVTSLLSIINDLLEQL 1524
            +Q+A   +     +  Q++        +A    +N+  A+++V +L  ++  LL+QL
Sbjct: 748  VQQATAPMANNLTNWSQNLQ---HFDSSAYNTAVNS--ARDAVRNLTEVVPQLLDQL 799



 Score =  133 bits (334), Expect = 2e-30
 Identities = 183/890 (20%), Positives = 336/890 (37%), Gaps = 167/890 (18%)

Query: 805  ELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRC 864
            E C+ G+F    G       C  C C+ N +      C   +G C+ C  NT G +C++C
Sbjct: 65   EKCNAGFFHTLSGE------CVPCDCNGNSN-----ECLDGSGYCVHCQRNTTGEHCEKC 113

Query: 865  KDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTG--QCECLPHVTGQDCGACDPG 922
             DG+ G+ +   P   C+ C C L        SC    G  +C C  +  G +C  C PG
Sbjct: 114  LDGYIGDSIRGAP-QFCQPCPCPLPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPG 172

Query: 923  FYN--LQSGQGCERCDCHALGSTN---GQCDIRTGQCE-CQPGITGQHCERCEVNHFGFG 976
            +Y   L  G  C++CDC      N     CD  TGQC  C    TG  CERC   ++G  
Sbjct: 173  YYGNPLLIGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYGDA 232

Query: 977  --PEGCKPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQ--ECP 1032
               + C  C+C             G C+   G       +C E  F   +   C    C 
Sbjct: 233  RIAKNCAVCNC-----------GGGPCDSVTG-------ECLEEGFEPPTGMDCPTISCD 274

Query: 1033 ACYRLVKDKVADHRVKLQELESLIANLGTGD------EMVTDQAFEDRLKEAEREVMDLL 1086
             C   + D +    + ++E +S + ++ +G         +    +  + K +ERE    L
Sbjct: 275  KCVWDLTDALRLAALSIEEGKSGVLSVSSGAAAHRHVNEINATIYLLKTKLSERENQYAL 334

Query: 1087 REAQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGNLAEQARAHVENTERLIE 1146
            R+ Q               +NN  ++  S L ++   +E+    + + +   + +   I 
Sbjct: 335  RKIQ---------------INNAENTMKSLLSDVEELVEKENQASRKGQLVQKESMDTIN 379

Query: 1147 IASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRVAKTAND 1206
             AS+ +E+A            +   + NN  L   E  +L+   K+ ++ +V   K   +
Sbjct: 380  HASQLVEQAH--------DMRDKIQEINNKMLYYGEEHELSP--KEISEKLVLAQKMLEE 429

Query: 1207 TSTEAYNLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVE 1266
              +       R L  E     E +E      QA++          R+H E +      +E
Sbjct: 430  IRSRQPFFTQRELVDE-----EADEAYELLSQAESWQ--------RLHNETRTLFPVVLE 476

Query: 1267 IYASV-AQLSPLDSETLENEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLL 1325
                  A+LS L  E L+   N ++ +AE++ +    + +D+E  +E +R +++EV N+ 
Sbjct: 477  QLDDYNAKLSDL-QEALDQALNYVR-DAEDMNRATAARQRDHEKQQERVR-EQMEVVNMS 533

Query: 1326 EKGKTEQQT---------------ADQLLARADAAKA---------------LAEEAAKK 1355
                 +  T               A  + A  D AK+               L +EA   
Sbjct: 534  LSTSADSLTTPRLTLSELDDIIKNASGIYAEIDGAKSELQVKLSNLSNLSHDLVQEAIDH 593

Query: 1356 GRDTLQEANDILNNLKDFD-----RRVNDNKTAAEEALRKIPAINQTITEANEKTREAQQ 1410
             +D  QEAN++   L   D     ++  D     E  +  +   N+T   A   T     
Sbjct: 594  AQDLQQEANELSRKLHSSDMNGLVQKALDASNVYENIVNYVSEANETAEFALNTTDRIYD 653

Query: 1411 ALGSAAAD----ATEAKNKAHEAERIASAVQKNATSTKAEAER----TFAEVTDLDNEVN 1462
            A+            E++N  ++A  + +  + ++    A+  R      A  + L   ++
Sbjct: 654  AVSGIDTQIIYHKDESENLLNQARELQAKAESSSDEAVADTSRRVGGALARKSALKTRLS 713

Query: 1463 NMLKQLQEAEKELKRKQDDADQDMMMAGMASQAAQEAEINARKA---------------- 1506
            + +KQLQ AE+       DA Q +  + + ++ A    +  ++A                
Sbjct: 714  DAVKQLQAAER------GDAQQRLGQSRLITEEANRTTMEVQQATAPMANNLTNWSQNLQ 767

Query: 1507 -------KNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDEMKVSDLDRKVS 1559
                     +V S    + +L E + QL    L++L  +E     +     +  +   ++
Sbjct: 768  HFDSSAYNTAVNSARDAVRNLTEVVPQL----LDQLRTVEQKRPASNVSASIQRIRELIA 823

Query: 1560 DLENEAKKQEAAIMDYNRDIEEIMKDIRNLEDIRKTLPSGCFNTPSIEKP 1609
               + A K + ++M   +   E+     +++D++       +  P +++P
Sbjct: 824  QTRSVASKIQVSMMFDGQSAVEV-HSRTSMDDLKAFTSLSLYMKPPVKRP 872



 Score =  115 bits (289), Expect = 3e-25
 Identities = 62/181 (34%), Positives = 88/181 (48%), Gaps = 28/181 (15%)

Query: 336 ASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFR---LGNN 392
           + EC+PCDCNG S EC             G+C +CQ NT G HCE+C + +      G  
Sbjct: 76  SGECVPCDCNGNSNECL---------DGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAP 126

Query: 393 EACSSCHCSPVGSLSTQCDS------YGRCSCKPGVMGDKCDRCQPGFHS---LTEAGCR 443
           + C  C C P+  L+   +S        RC C     G  C+RC PG++    L  + C+
Sbjct: 127 QFCQPCPC-PLPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPGYYGNPLLIGSTCK 185

Query: 444 PCSC----DPSGSIDECNIETGRC-VCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCF 498
            C C    DP+   ++C+  TG+C  C  N  GF CERC PG++  ++   + C  C C 
Sbjct: 186 KCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYG-DARIAKNCAVCNCG 244

Query: 499 G 499
           G
Sbjct: 245 G 245



 Score =  102 bits (253), Expect = 4e-21
 Identities = 60/170 (35%), Positives = 82/170 (48%), Gaps = 23/170 (13%)

Query: 692 CPVGYGGQFCEMCLSGY----RRETPNLGPYSPCVLCACNGHSETCDPETGV--CNCRDN 745
           C     G+ CE CL GY     R  P      PC L      +E+C  + G   C C +N
Sbjct: 101 CQRNTTGEHCEKCLDGYIGDSIRGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCICNEN 160

Query: 746 TAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVV---CTNCPTGTTGK 802
            AGP+CE+C+ GYYG+      S C+ C C G S   ++ +  + V   C NC   TTG 
Sbjct: 161 YAGPNCERCAPGYYGNPLL-IGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGF 219

Query: 803 RCELCDDGYFGDP-LGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLK 851
           +CE C  GY+GD  + +N     C +C C         G C+ +TGECL+
Sbjct: 220 KCERCAPGYYGDARIAKN-----CAVCNCGG-------GPCDSVTGECLE 257



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 76/277 (27%), Positives = 112/277 (40%), Gaps = 53/277 (19%)

Query: 227 GRPSAYNFD----NSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAV 282
           G  +A+ FD    ++   Q+    ++ RV L RL    +      K    +++ +S   V
Sbjct: 27  GDDNAFPFDIEGSSAVGRQDPPETSEPRVALGRLPPAAE------KCNAGFFHTLSGECV 80

Query: 283 GGRCKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPC 342
              C CNG+++EC+         +C+ NT G  CEKCL  +     R A       C PC
Sbjct: 81  P--CDCNGNSNECLDGS--GYCVHCQRNTTGEHCEKCLDGYIGDSIRGA----PQFCQPC 132

Query: 343 DCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGN----NEACSSC 398
            C        F    YR  G    C  C +N  G +CERC   ++  GN       C  C
Sbjct: 133 PC-PLPHLANFAESCYRKNG-AVRCI-CNENYAGPNCERCAPGYY--GNPLLIGSTCKKC 187

Query: 399 HC---SPVGSLSTQCDSY-GRC-SCKPGVMGDKCDRCQPGFH--SLTEAGCRPCSCDPSG 451
            C   S    +   CD   G+C +C     G KC+RC PG++  +     C  C+C    
Sbjct: 188 DCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYGDARIAKNCAVCNCGGG- 246

Query: 452 SIDECNIETGRCVCKDNVEGF-----------NCERC 477
               C+  TG C+     EGF           +C++C
Sbjct: 247 ---PCDSVTGECL----EEGFEPPTGMDCPTISCDKC 276



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 43/107 (40%), Positives = 52/107 (48%), Gaps = 11/107 (10%)

Query: 690 CTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHS------ETCDPETGVC-NC 742
           C C   Y G  CE C  GY      +G  S C  C C+G+S      E CD  TG C NC
Sbjct: 155 CICNENYAGPNCERCAPGYYGNPLLIG--STCKKCDCSGNSDPNLIFEDCDEVTGQCRNC 212

Query: 743 RDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKE 789
             NT G  CE+C+ GYYGD  A  + +C  C C GG   +V  +  E
Sbjct: 213 LRNTTGFKCERCAPGYYGD--ARIAKNCAVCNCGGGPCDSVTGECLE 257



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 41/132 (31%), Positives = 61/132 (46%), Gaps = 13/132 (9%)

Query: 380 ERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSYGRC-SCKPGVMGDKCDRCQPGFHSLT 438
           E+C   FF   + E C  C C+  G+ +   D  G C  C+    G+ C++C  G+   +
Sbjct: 65  EKCNAGFFHTLSGE-CVPCDCN--GNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDS 121

Query: 439 EAG----CRPCSCDP---SGSIDECNIETG--RCVCKDNVEGFNCERCKPGFFNLESSNP 489
             G    C+PC C     +   + C  + G  RC+C +N  G NCERC PG++       
Sbjct: 122 IRGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPGYYGNPLLIG 181

Query: 490 RGCTPCFCFGHS 501
             C  C C G+S
Sbjct: 182 STCKKCDCSGNS 193



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 17/44 (38%), Positives = 24/44 (54%), Gaps = 3/44 (6%)

Query: 475 ERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISST 518
           E+C  GFF+  S     C PC C G+S+ C +  GY V+   +T
Sbjct: 65  EKCNAGFFHTLSGE---CVPCDCNGNSNECLDGSGYCVHCQRNT 105


>gi|157419126 laminin, alpha 4 isoform 2 precursor [Homo sapiens]
          Length = 1816

 Score =  156 bits (395), Expect = 1e-37
 Identities = 186/835 (22%), Positives = 330/835 (39%), Gaps = 135/835 (16%)

Query: 735  PETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTN 794
            PET           P  EKC+ G++       S +C PC C G S+  +        C +
Sbjct: 48   PETSEPRVALGRLPPAAEKCNAGFFHT----LSGECVPCDCNGNSNECL---DGSGYCVH 100

Query: 795  CPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIY 854
            C   TTG+ CE C DGY GD +   G  + C+ C C      N   +C R  G  ++CI 
Sbjct: 101  CQRNTTGEHCEKCLDGYIGDSI--RGAPQFCQPCPCPLPHLANFAESCYRKNG-AVRCIC 157

Query: 855  NT--AGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQ---SSCNPVTGQCE-CL 908
            N   AG  C+RC  G++GNPL       CK C+C+  G          C+ VTGQC  CL
Sbjct: 158  NENYAGPNCERCAPGYYGNPLLIGST--CKKCDCS--GNSDPNLIFEDCDEVTGQCRNCL 213

Query: 909  PHVTGQDCGACDPGFY-NLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCER 967
             + TG  C  C PG+Y + +  + C  C+C       G CD  TG+C  + G        
Sbjct: 214  RNTTGFKCERCAPGYYGDARIAKNCAVCNC-----GGGPCDSVTGEC-LEEGFE------ 261

Query: 968  CEVNHFGFGPEGCKPC-----DCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYN 1022
                     P GC  C     D     +LS++    G      G   +R           
Sbjct: 262  --------PPTGCDKCVWDLTDALRLAALSIEEGKSGVLSVSSGAAAHR----------- 302

Query: 1023 RSWPGCQECPACYRLVKDKVAD-------HRVKLQELESLIANLGTGDEMVTDQAFEDRL 1075
                   E  A   L+K K+++        ++++   E+ + +L +  E + ++  +   
Sbjct: 303  ----HVNEINATIYLLKTKLSERENQYALRKIQINNAENTMKSLLSDVEELVEKENQASR 358

Query: 1076 KE--AEREVMDLLREAQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGNLAEQ 1133
            K    ++E MD +  A  + +   ++ D++Q +NN +       +     I E   LA++
Sbjct: 359  KGQLVQKESMDTINHASQLVEQAHDMRDKIQEINNKMLYYGEEHELSPKEISEKLVLAQK 418

Query: 1134 ARAHVENTERLIEIASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQE 1193
                + + +       REL   +   A   ++Q ES         L  E R L     ++
Sbjct: 419  MLEEIRSRQPF--FTQRELVDEEADEAYELLSQAES------WQRLHNETRTLFPVVLEQ 470

Query: 1194 ADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAARV 1253
             DD         +   +A N +            + E++NR     +   +D EKQ  RV
Sbjct: 471  LDDYNAKLSDLQEALDQALNYVR-----------DAEDMNRATAARQ---RDHEKQQERV 516

Query: 1254 HEEAK----RAGDKAVEIYASVAQLSPLDSETLENEANNIKMEAENLEQLIDQKLKDYED 1309
             E+ +         A  +      LS LD   +   A+ I  E +  +  +  KL +  +
Sbjct: 517  REQMEVVNMSLSTSADSLTTPRLTLSELDD--IIKNASGIYAEIDGAKSELQVKLSNLSN 574

Query: 1310 LREDMRGKELEVKNLLEKGKTEQQTADQLLARADAA-------KAL------------AE 1350
            L  D+      V+  ++  +  QQ A++L  +  ++       KAL              
Sbjct: 575  LSHDL------VQEAIDHAQDLQQEANELSRKLHSSDMNGLVQKALDASNVYENIVNYVS 628

Query: 1351 EAAKKGRDTLQEANDILNNLKDFDRRVNDNKTAAEEALRKIPAIN-QTITEANEKTREAQ 1409
            EA +     L   + I + +   D ++  +K  +E  L +   +  +  + ++E   +  
Sbjct: 629  EANETAEFALNTTDRIYDAVSGIDTQIIYHKDESENLLNQARELQAKAESSSDEAVADTS 688

Query: 1410 QALGSAAADATEAKNKAHEAERIASAVQKNATSTKAEAERTFAEVTDLDNEVNNMLKQLQ 1469
            + +G A A  +  K       R++ AV++   + + +A++   +   +  E N    ++Q
Sbjct: 689  RRVGGALARKSALKT------RLSDAVKQLQAAERGDAQQRLGQSRLITEEANRTTMEVQ 742

Query: 1470 EAEKELKRKQDDADQDMMMAGMASQAAQEAEINARKAKNSVTSLLSIINDLLEQL 1524
            +A   +     +  Q++        +A    +N+  A+++V +L  ++  LL+QL
Sbjct: 743  QATAPMANNLTNWSQNLQ---HFDSSAYNTAVNS--ARDAVRNLTEVVPQLLDQL 792



 Score =  152 bits (384), Expect = 3e-36
 Identities = 78/191 (40%), Positives = 99/191 (51%), Gaps = 20/191 (10%)

Query: 721 CVLCACNGHSETCDPETGVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCP--- 776
           CV C CNG+S  C   +G C +C+ NT G HCEKC DGY GDS  G    CQPCPCP   
Sbjct: 79  CVPCDCNGNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAPQFCQPCPCPLPH 138

Query: 777 -GGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNID 835
               + +   K   V C  C     G  CE C  GY+G+PL        C+ C CS N D
Sbjct: 139 LANFAESCYRKNGAVRCI-CNENYAGPNCERCAPGYYGNPLLIGS---TCKKCDCSGNSD 194

Query: 836 PNAV-GNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQ 894
           PN +  +C+ +TG+C  C+ NT GF C+RC  G++G+      A  C  CNC        
Sbjct: 195 PNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYGD---ARIAKNCAVCNCG------- 244

Query: 895 QSSCNPVTGQC 905
              C+ VTG+C
Sbjct: 245 GGPCDSVTGEC 255



 Score =  115 bits (289), Expect = 3e-25
 Identities = 62/181 (34%), Positives = 88/181 (48%), Gaps = 28/181 (15%)

Query: 336 ASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFR---LGNN 392
           + EC+PCDCNG S EC             G+C +CQ NT G HCE+C + +      G  
Sbjct: 76  SGECVPCDCNGNSNECL---------DGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAP 126

Query: 393 EACSSCHCSPVGSLSTQCDS------YGRCSCKPGVMGDKCDRCQPGFHS---LTEAGCR 443
           + C  C C P+  L+   +S        RC C     G  C+RC PG++    L  + C+
Sbjct: 127 QFCQPCPC-PLPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPGYYGNPLLIGSTCK 185

Query: 444 PCSC----DPSGSIDECNIETGRC-VCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCF 498
            C C    DP+   ++C+  TG+C  C  N  GF CERC PG++  ++   + C  C C 
Sbjct: 186 KCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYG-DARIAKNCAVCNCG 244

Query: 499 G 499
           G
Sbjct: 245 G 245



 Score =  103 bits (257), Expect = 1e-21
 Identities = 65/187 (34%), Positives = 88/187 (47%), Gaps = 32/187 (17%)

Query: 692 CPVGYGGQFCEMCLSGY----RRETPNLGPYSPCVLCACNGHSETCDPETGV--CNCRDN 745
           C     G+ CE CL GY     R  P      PC L      +E+C  + G   C C +N
Sbjct: 101 CQRNTTGEHCEKCLDGYIGDSIRGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCICNEN 160

Query: 746 TAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVV---CTNCPTGTTGK 802
            AGP+CE+C+ GYYG+      S C+ C C G S   ++ +  + V   C NC   TTG 
Sbjct: 161 YAGPNCERCAPGYYGNPLL-IGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGF 219

Query: 803 RCELCDDGYFGDP-LGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFY- 860
           +CE C  GY+GD  + +N     C +C C         G C+ +TGECL+      GF  
Sbjct: 220 KCERCAPGYYGDARIAKN-----CAVCNCGG-------GPCDSVTGECLE-----EGFEP 262

Query: 861 ---CDRC 864
              CD+C
Sbjct: 263 PTGCDKC 269



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 73/266 (27%), Positives = 109/266 (40%), Gaps = 38/266 (14%)

Query: 227 GRPSAYNFD----NSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAV 282
           G  +A+ FD    ++   Q+    ++ RV L RL    +      K    +++ +S   V
Sbjct: 27  GDDNAFPFDIEGSSAVGRQDPPETSEPRVALGRLPPAAE------KCNAGFFHTLSGECV 80

Query: 283 GGRCKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPC 342
              C CNG+++EC+         +C+ NT G  CEKCL  +     R A       C PC
Sbjct: 81  P--CDCNGNSNECLDGS--GYCVHCQRNTTGEHCEKCLDGYIGDSIRGA----PQFCQPC 132

Query: 343 DCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGN----NEACSSC 398
            C        F    YR  G    C  C +N  G +CERC   ++  GN       C  C
Sbjct: 133 PC-PLPHLANFAESCYRKNG-AVRCI-CNENYAGPNCERCAPGYY--GNPLLIGSTCKKC 187

Query: 399 HC---SPVGSLSTQCDSY-GRC-SCKPGVMGDKCDRCQPGFH--SLTEAGCRPCSCDPSG 451
            C   S    +   CD   G+C +C     G KC+RC PG++  +     C  C+C    
Sbjct: 188 DCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYGDARIAKNCAVCNCGGG- 246

Query: 452 SIDECNIETGRCVCKDNVEGFNCERC 477
               C+  TG C+ +       C++C
Sbjct: 247 ---PCDSVTGECLEEGFEPPTGCDKC 269



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 43/107 (40%), Positives = 52/107 (48%), Gaps = 11/107 (10%)

Query: 690 CTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHS------ETCDPETGVC-NC 742
           C C   Y G  CE C  GY      +G  S C  C C+G+S      E CD  TG C NC
Sbjct: 155 CICNENYAGPNCERCAPGYYGNPLLIG--STCKKCDCSGNSDPNLIFEDCDEVTGQCRNC 212

Query: 743 RDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKE 789
             NT G  CE+C+ GYYGD  A  + +C  C C GG   +V  +  E
Sbjct: 213 LRNTTGFKCERCAPGYYGD--ARIAKNCAVCNCGGGPCDSVTGECLE 257



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 41/132 (31%), Positives = 61/132 (46%), Gaps = 13/132 (9%)

Query: 380 ERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSYGRC-SCKPGVMGDKCDRCQPGFHSLT 438
           E+C   FF   + E C  C C+  G+ +   D  G C  C+    G+ C++C  G+   +
Sbjct: 65  EKCNAGFFHTLSGE-CVPCDCN--GNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDS 121

Query: 439 EAG----CRPCSCDP---SGSIDECNIETG--RCVCKDNVEGFNCERCKPGFFNLESSNP 489
             G    C+PC C     +   + C  + G  RC+C +N  G NCERC PG++       
Sbjct: 122 IRGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPGYYGNPLLIG 181

Query: 490 RGCTPCFCFGHS 501
             C  C C G+S
Sbjct: 182 STCKKCDCSGNS 193



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 17/44 (38%), Positives = 24/44 (54%), Gaps = 3/44 (6%)

Query: 475 ERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISST 518
           E+C  GFF+  S     C PC C G+S+ C +  GY V+   +T
Sbjct: 65  EKCNAGFFHTLSGE---CVPCDCNGNSNECLDGSGYCVHCQRNT 105


>gi|157419122 laminin, alpha 4 isoform 2 precursor [Homo sapiens]
          Length = 1816

 Score =  156 bits (395), Expect = 1e-37
 Identities = 186/835 (22%), Positives = 330/835 (39%), Gaps = 135/835 (16%)

Query: 735  PETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTN 794
            PET           P  EKC+ G++       S +C PC C G S+  +        C +
Sbjct: 48   PETSEPRVALGRLPPAAEKCNAGFFHT----LSGECVPCDCNGNSNECL---DGSGYCVH 100

Query: 795  CPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIY 854
            C   TTG+ CE C DGY GD +   G  + C+ C C      N   +C R  G  ++CI 
Sbjct: 101  CQRNTTGEHCEKCLDGYIGDSI--RGAPQFCQPCPCPLPHLANFAESCYRKNG-AVRCIC 157

Query: 855  NT--AGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQ---SSCNPVTGQCE-CL 908
            N   AG  C+RC  G++GNPL       CK C+C+  G          C+ VTGQC  CL
Sbjct: 158  NENYAGPNCERCAPGYYGNPLLIGST--CKKCDCS--GNSDPNLIFEDCDEVTGQCRNCL 213

Query: 909  PHVTGQDCGACDPGFY-NLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCER 967
             + TG  C  C PG+Y + +  + C  C+C       G CD  TG+C  + G        
Sbjct: 214  RNTTGFKCERCAPGYYGDARIAKNCAVCNC-----GGGPCDSVTGEC-LEEGFE------ 261

Query: 968  CEVNHFGFGPEGCKPC-----DCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYN 1022
                     P GC  C     D     +LS++    G      G   +R           
Sbjct: 262  --------PPTGCDKCVWDLTDALRLAALSIEEGKSGVLSVSSGAAAHR----------- 302

Query: 1023 RSWPGCQECPACYRLVKDKVAD-------HRVKLQELESLIANLGTGDEMVTDQAFEDRL 1075
                   E  A   L+K K+++        ++++   E+ + +L +  E + ++  +   
Sbjct: 303  ----HVNEINATIYLLKTKLSERENQYALRKIQINNAENTMKSLLSDVEELVEKENQASR 358

Query: 1076 KE--AEREVMDLLREAQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGNLAEQ 1133
            K    ++E MD +  A  + +   ++ D++Q +NN +       +     I E   LA++
Sbjct: 359  KGQLVQKESMDTINHASQLVEQAHDMRDKIQEINNKMLYYGEEHELSPKEISEKLVLAQK 418

Query: 1134 ARAHVENTERLIEIASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQE 1193
                + + +       REL   +   A   ++Q ES         L  E R L     ++
Sbjct: 419  MLEEIRSRQPF--FTQRELVDEEADEAYELLSQAES------WQRLHNETRTLFPVVLEQ 470

Query: 1194 ADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAARV 1253
             DD         +   +A N +            + E++NR     +   +D EKQ  RV
Sbjct: 471  LDDYNAKLSDLQEALDQALNYVR-----------DAEDMNRATAARQ---RDHEKQQERV 516

Query: 1254 HEEAK----RAGDKAVEIYASVAQLSPLDSETLENEANNIKMEAENLEQLIDQKLKDYED 1309
             E+ +         A  +      LS LD   +   A+ I  E +  +  +  KL +  +
Sbjct: 517  REQMEVVNMSLSTSADSLTTPRLTLSELDD--IIKNASGIYAEIDGAKSELQVKLSNLSN 574

Query: 1310 LREDMRGKELEVKNLLEKGKTEQQTADQLLARADAA-------KAL------------AE 1350
            L  D+      V+  ++  +  QQ A++L  +  ++       KAL              
Sbjct: 575  LSHDL------VQEAIDHAQDLQQEANELSRKLHSSDMNGLVQKALDASNVYENIVNYVS 628

Query: 1351 EAAKKGRDTLQEANDILNNLKDFDRRVNDNKTAAEEALRKIPAIN-QTITEANEKTREAQ 1409
            EA +     L   + I + +   D ++  +K  +E  L +   +  +  + ++E   +  
Sbjct: 629  EANETAEFALNTTDRIYDAVSGIDTQIIYHKDESENLLNQARELQAKAESSSDEAVADTS 688

Query: 1410 QALGSAAADATEAKNKAHEAERIASAVQKNATSTKAEAERTFAEVTDLDNEVNNMLKQLQ 1469
            + +G A A  +  K       R++ AV++   + + +A++   +   +  E N    ++Q
Sbjct: 689  RRVGGALARKSALKT------RLSDAVKQLQAAERGDAQQRLGQSRLITEEANRTTMEVQ 742

Query: 1470 EAEKELKRKQDDADQDMMMAGMASQAAQEAEINARKAKNSVTSLLSIINDLLEQL 1524
            +A   +     +  Q++        +A    +N+  A+++V +L  ++  LL+QL
Sbjct: 743  QATAPMANNLTNWSQNLQ---HFDSSAYNTAVNS--ARDAVRNLTEVVPQLLDQL 792



 Score =  152 bits (384), Expect = 3e-36
 Identities = 78/191 (40%), Positives = 99/191 (51%), Gaps = 20/191 (10%)

Query: 721 CVLCACNGHSETCDPETGVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCP--- 776
           CV C CNG+S  C   +G C +C+ NT G HCEKC DGY GDS  G    CQPCPCP   
Sbjct: 79  CVPCDCNGNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAPQFCQPCPCPLPH 138

Query: 777 -GGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNID 835
               + +   K   V C  C     G  CE C  GY+G+PL        C+ C CS N D
Sbjct: 139 LANFAESCYRKNGAVRCI-CNENYAGPNCERCAPGYYGNPLLIGS---TCKKCDCSGNSD 194

Query: 836 PNAV-GNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQ 894
           PN +  +C+ +TG+C  C+ NT GF C+RC  G++G+      A  C  CNC        
Sbjct: 195 PNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYGD---ARIAKNCAVCNCG------- 244

Query: 895 QSSCNPVTGQC 905
              C+ VTG+C
Sbjct: 245 GGPCDSVTGEC 255



 Score =  115 bits (289), Expect = 3e-25
 Identities = 62/181 (34%), Positives = 88/181 (48%), Gaps = 28/181 (15%)

Query: 336 ASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFR---LGNN 392
           + EC+PCDCNG S EC             G+C +CQ NT G HCE+C + +      G  
Sbjct: 76  SGECVPCDCNGNSNECL---------DGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAP 126

Query: 393 EACSSCHCSPVGSLSTQCDS------YGRCSCKPGVMGDKCDRCQPGFHS---LTEAGCR 443
           + C  C C P+  L+   +S        RC C     G  C+RC PG++    L  + C+
Sbjct: 127 QFCQPCPC-PLPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPGYYGNPLLIGSTCK 185

Query: 444 PCSC----DPSGSIDECNIETGRC-VCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCF 498
            C C    DP+   ++C+  TG+C  C  N  GF CERC PG++  ++   + C  C C 
Sbjct: 186 KCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYG-DARIAKNCAVCNCG 244

Query: 499 G 499
           G
Sbjct: 245 G 245



 Score =  103 bits (257), Expect = 1e-21
 Identities = 65/187 (34%), Positives = 88/187 (47%), Gaps = 32/187 (17%)

Query: 692 CPVGYGGQFCEMCLSGY----RRETPNLGPYSPCVLCACNGHSETCDPETGV--CNCRDN 745
           C     G+ CE CL GY     R  P      PC L      +E+C  + G   C C +N
Sbjct: 101 CQRNTTGEHCEKCLDGYIGDSIRGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCICNEN 160

Query: 746 TAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVV---CTNCPTGTTGK 802
            AGP+CE+C+ GYYG+      S C+ C C G S   ++ +  + V   C NC   TTG 
Sbjct: 161 YAGPNCERCAPGYYGNPLL-IGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGF 219

Query: 803 RCELCDDGYFGDP-LGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFY- 860
           +CE C  GY+GD  + +N     C +C C         G C+ +TGECL+      GF  
Sbjct: 220 KCERCAPGYYGDARIAKN-----CAVCNCGG-------GPCDSVTGECLE-----EGFEP 262

Query: 861 ---CDRC 864
              CD+C
Sbjct: 263 PTGCDKC 269



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 73/266 (27%), Positives = 109/266 (40%), Gaps = 38/266 (14%)

Query: 227 GRPSAYNFD----NSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAV 282
           G  +A+ FD    ++   Q+    ++ RV L RL    +      K    +++ +S   V
Sbjct: 27  GDDNAFPFDIEGSSAVGRQDPPETSEPRVALGRLPPAAE------KCNAGFFHTLSGECV 80

Query: 283 GGRCKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPC 342
              C CNG+++EC+         +C+ NT G  CEKCL  +     R A       C PC
Sbjct: 81  P--CDCNGNSNECLDGS--GYCVHCQRNTTGEHCEKCLDGYIGDSIRGA----PQFCQPC 132

Query: 343 DCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGN----NEACSSC 398
            C        F    YR  G    C  C +N  G +CERC   ++  GN       C  C
Sbjct: 133 PC-PLPHLANFAESCYRKNG-AVRCI-CNENYAGPNCERCAPGYY--GNPLLIGSTCKKC 187

Query: 399 HC---SPVGSLSTQCDSY-GRC-SCKPGVMGDKCDRCQPGFH--SLTEAGCRPCSCDPSG 451
            C   S    +   CD   G+C +C     G KC+RC PG++  +     C  C+C    
Sbjct: 188 DCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYGDARIAKNCAVCNCGGG- 246

Query: 452 SIDECNIETGRCVCKDNVEGFNCERC 477
               C+  TG C+ +       C++C
Sbjct: 247 ---PCDSVTGECLEEGFEPPTGCDKC 269



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 43/107 (40%), Positives = 52/107 (48%), Gaps = 11/107 (10%)

Query: 690 CTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHS------ETCDPETGVC-NC 742
           C C   Y G  CE C  GY      +G  S C  C C+G+S      E CD  TG C NC
Sbjct: 155 CICNENYAGPNCERCAPGYYGNPLLIG--STCKKCDCSGNSDPNLIFEDCDEVTGQCRNC 212

Query: 743 RDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKE 789
             NT G  CE+C+ GYYGD  A  + +C  C C GG   +V  +  E
Sbjct: 213 LRNTTGFKCERCAPGYYGD--ARIAKNCAVCNCGGGPCDSVTGECLE 257



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 41/132 (31%), Positives = 61/132 (46%), Gaps = 13/132 (9%)

Query: 380 ERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSYGRC-SCKPGVMGDKCDRCQPGFHSLT 438
           E+C   FF   + E C  C C+  G+ +   D  G C  C+    G+ C++C  G+   +
Sbjct: 65  EKCNAGFFHTLSGE-CVPCDCN--GNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDS 121

Query: 439 EAG----CRPCSCDP---SGSIDECNIETG--RCVCKDNVEGFNCERCKPGFFNLESSNP 489
             G    C+PC C     +   + C  + G  RC+C +N  G NCERC PG++       
Sbjct: 122 IRGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPGYYGNPLLIG 181

Query: 490 RGCTPCFCFGHS 501
             C  C C G+S
Sbjct: 182 STCKKCDCSGNS 193



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 17/44 (38%), Positives = 24/44 (54%), Gaps = 3/44 (6%)

Query: 475 ERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISST 518
           E+C  GFF+  S     C PC C G+S+ C +  GY V+   +T
Sbjct: 65  EKCNAGFFHTLSGE---CVPCDCNGNSNECLDGSGYCVHCQRNT 105


>gi|24308065 netrin 5 [Homo sapiens]
          Length = 489

 Score =  150 bits (378), Expect = 1e-35
 Identities = 112/427 (26%), Positives = 161/427 (37%), Gaps = 118/427 (27%)

Query: 34  QAAMDECTDEGGRPQRCMPEFVNAAFNVTVVATNTCGTPPEEYCVQTGVTGVTKSCHLCD 93
           QA  D C D  GRPQ C+P     A  V       C   P  +       G  ++C+   
Sbjct: 13  QATADPCYDPQGRPQFCLPPVTQLAA-VAASCPQACALSPGNHL------GARETCNG-- 63

Query: 94  AGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKFH 153
                                                   +LTL LG  F +T V L+F 
Sbjct: 64  ----------------------------------------SLTLALGGPFLLTSVSLRFC 83

Query: 154 TSRPESFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDIS 213
           T  P +  +       GPW                                         
Sbjct: 84  TPGPPALILSAAWASGGPW----------------------------------------- 102

Query: 214 PLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSY 273
            L     A+    G P    F ++P  +  V A+ +RV       FG +           
Sbjct: 103 RLLWHRPAWPGALGGPERVTFHSTPGPKATVAASHLRVE------FGGQA---------- 146

Query: 274 YYAISDFAVGGRCKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATA 333
              ++   + GRC+C+GHA+ C         C+C+H+T G  CE C P   D PWR AT 
Sbjct: 147 --GLAAAGLRGRCQCHGHAARCAARARPPR-CHCRHHTTGPGCESCRPSHRDWPWRPATP 203

Query: 334 ESASECLPCDCNGRSQECYFDPELYRSTG--HGGHCTNCQDNTDGAHCERCRENFFR--- 388
                CLPC CN  ++ C F+ EL+R +G   GG C  C+ +T G HC  C+  F+R   
Sbjct: 204 RHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGVCERCRHHTAGRHCHYCQPGFWRDPS 263

Query: 389 --LGNNEACSSCHCSPVGSLSTQCD-SYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPC 445
             + +  AC +C C P+G+    C+ + G+C+CK GV G  C+RC PG+   + +   PC
Sbjct: 264 QPIFSRRACRACQCHPIGATGGTCNQTSGQCTCKLGVTGLTCNRCGPGYQQ-SRSPRMPC 322

Query: 446 SCDPSGS 452
              P  +
Sbjct: 323 QRIPEAT 329



 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 49/161 (30%), Positives = 71/161 (44%), Gaps = 24/161 (14%)

Query: 852 CIYNTAGFYCDRCKDGFFG---NPLAPNPADKCKACNCNLYGTMKQ------QSSCNPVT 902
           C ++T G  C+ C+         P  P     C  C+CN +    +      + S     
Sbjct: 177 CRHHTTGPGCESCRPSHRDWPWRPATPRHPHPCLPCSCNQHARRCRFNSELFRLSGGRSG 236

Query: 903 GQCE-CLPHVTGQDCGACDPGFYN-----LQSGQGCERCDCHALGSTNGQCDIRTGQCEC 956
           G CE C  H  G+ C  C PGF+      + S + C  C CH +G+T G C+  +GQC C
Sbjct: 237 GVCERCRHHTAGRHCHYCQPGFWRDPSQPIFSRRACRACQCHPIGATGGTCNQTSGQCTC 296

Query: 957 QPGITGQHCERCEVNHFGFGPEGCK----PCDCHPEGSLSL 993
           + G+TG  C RC     G G +  +    PC   PE + +L
Sbjct: 297 KLGVTGLTCNRC-----GPGYQQSRSPRMPCQRIPEATTTL 332



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 59/199 (29%), Positives = 86/199 (43%), Gaps = 19/199 (9%)

Query: 747 AGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSS-CAVVPKTKEVVCTNCPTGTTGKRCE 805
           A  H      G  G + AG    CQ   C G ++ CA   + +   C +C   TTG  CE
Sbjct: 134 AASHLRVEFGGQAGLAAAGLRGRCQ---CHGHAARCAA--RARPPRC-HCRHHTTGPGCE 187

Query: 806 LCDDGYFGDPLGRNGP--VRLCRLCQCSDNIDPNAVGN------CNRLTGECLKCIYNTA 857
            C   +   P     P     C  C C+ +       +        R  G C +C ++TA
Sbjct: 188 SCRPSHRDWPWRPATPRHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGVCERCRHHTA 247

Query: 858 GFYCDRCKDGFFGNPLAPNPADK-CKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDC 916
           G +C  C+ GF+ +P  P  + + C+AC C+  G      +CN  +GQC C   VTG  C
Sbjct: 248 GRHCHYCQPGFWRDPSQPIFSRRACRACQCHPIGA--TGGTCNQTSGQCTCKLGVTGLTC 305

Query: 917 GACDPGFYNLQSGQ-GCER 934
             C PG+   +S +  C+R
Sbjct: 306 NRCGPGYQQSRSPRMPCQR 324



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 46/141 (32%), Positives = 59/141 (41%), Gaps = 22/141 (15%)

Query: 690 CTCPVGYGGQFCEMCLSGYR----RETPNLGPYSPCVLCACNGHSETC-----------D 734
           C C     G  CE C   +R    R      P+ PC+ C+CN H+  C            
Sbjct: 175 CHCRHHTTGPGCESCRPSHRDWPWRPATPRHPH-PCLPCSCNQHARRCRFNSELFRLSGG 233

Query: 735 PETGVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSS--DCQPCPC-PGGSSCAVVPKTKEV 790
              GVC  CR +TAG HC  C  G++ D +    S   C+ C C P G++     +T   
Sbjct: 234 RSGGVCERCRHHTAGRHCHYCQPGFWRDPSQPIFSRRACRACQCHPIGATGGTCNQTSG- 292

Query: 791 VCTNCPTGTTGKRCELCDDGY 811
            CT C  G TG  C  C  GY
Sbjct: 293 QCT-CKLGVTGLTCNRCGPGY 312



 Score = 61.2 bits (147), Expect = 8e-09
 Identities = 42/159 (26%), Positives = 59/159 (37%), Gaps = 36/159 (22%)

Query: 904  QCECLPHVTGQDCGACDPGFYNL-------QSGQGCERCDC--HAL-------------G 941
            +C C  H TG  C +C P   +        +    C  C C  HA              G
Sbjct: 174  RCHCRHHTTGPGCESCRPSHRDWPWRPATPRHPHPCLPCSCNQHARRCRFNSELFRLSGG 233

Query: 942  STNGQCDIRTGQCECQPGITGQHCERCEVNHFG------FGPEGCKPCDCHPEGSLSLQC 995
             + G C+       C+    G+HC  C+   +       F    C+ C CHP G+    C
Sbjct: 234  RSGGVCE------RCRHHTAGRHCHYCQPGFWRDPSQPIFSRRACRACQCHPIGATGGTC 287

Query: 996  KD-DGRCECREGFVGNRCDQCEENYFYNRS-WPGCQECP 1032
                G+C C+ G  G  C++C   Y  +RS    CQ  P
Sbjct: 288  NQTSGQCTCKLGVTGLTCNRCGPGYQQSRSPRMPCQRIP 326



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 32/124 (25%), Positives = 46/124 (37%), Gaps = 27/124 (21%)

Query: 934  RCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGF--------GPEGCKPCDC 985
            RC CH   +       R  +C C+   TG  CE C  +H  +         P  C PC C
Sbjct: 156  RCQCHG-HAARCAARARPPRCHCRHHTTGPGCESCRPSHRDWPWRPATPRHPHPCLPCSC 214

Query: 986  HPEGSLSLQC------------KDDGRCE-CREGFVGNRCDQCEENYFYNRSWP--GCQE 1030
            +     + +C            +  G CE CR    G  C  C+  ++ + S P    + 
Sbjct: 215  NQH---ARRCRFNSELFRLSGGRSGGVCERCRHHTAGRHCHYCQPGFWRDPSQPIFSRRA 271

Query: 1031 CPAC 1034
            C AC
Sbjct: 272  CRAC 275



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 22/78 (28%), Positives = 29/78 (37%), Gaps = 6/78 (7%)

Query: 433 GFHSLTEAGCRP-CSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPGFFN-----LES 486
           G   L  AG R  C C    +         RC C+ +  G  CE C+P   +        
Sbjct: 144 GQAGLAAAGLRGRCQCHGHAARCAARARPPRCHCRHHTTGPGCESCRPSHRDWPWRPATP 203

Query: 487 SNPRGCTPCFCFGHSSVC 504
            +P  C PC C  H+  C
Sbjct: 204 RHPHPCLPCSCNQHARRC 221


>gi|54312078 netrin G1 isoform 3 [Homo sapiens]
          Length = 438

 Score =  145 bits (367), Expect = 2e-34
 Identities = 106/343 (30%), Positives = 153/343 (44%), Gaps = 40/343 (11%)

Query: 68  TCGTPPEEYCVQTGVTGVTKSCHL-CDAGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAG 126
           TCG PPE +C      G    C+  CDA  P L H    + D+  +  +T+WQS T    
Sbjct: 71  TCGDPPETFCAM----GNPYMCNNECDASTPELAHPPELMFDFEGRHPSTFWQSATWK-- 124

Query: 127 VQYPS--SINLTLHLGKAFDIT-YVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCE 183
            +YP    +N+TL   K  ++T  + + F + RP+   + K       W PYQYY+  C 
Sbjct: 125 -EYPKPLQVNITLSWSKTIELTDNIVITFESGRPDQMILEKSLDYGRTWQPYQYYATDCL 183

Query: 184 NTYSKANRGFIRTGGDEQ-QALCTDEFSDISPLTGGNVAFST-----------LEGRPSA 231
           + +    +           + +CT+E+S         + F             L    S 
Sbjct: 184 DAFHMDPKSVKDLSQHTVLEIICTEEYSTGYTTNSKIIHFEIKDRFAFFAGPRLRNMASL 243

Query: 232 YN-FDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNG 290
           Y   D +  L+++ T TD+R+ L  L     E+F D   L  Y+YAISD  V GRCKCN 
Sbjct: 244 YGQLDTTKKLRDFFTVTDLRIRL--LRPAVGEIFVDELHLARYFYAISDIKVRGRCKCNL 301

Query: 291 HASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRAT-----AESASECLPCDCN 345
           HA+ C+ +   KL C C+HNT G DC KC   +  RPW   +       +A+ C+P   +
Sbjct: 302 HATVCVYDN-SKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPSISS 360

Query: 346 GRSQECYFDPELYRSTGHGGHCTN-----CQDNTDGAHCERCR 383
             +  C  D EL     +GG C N     C     G  CE+ R
Sbjct: 361 IGTNVC--DNELLHCQ-NGGTCHNNVRCLCPAAYTGILCEKLR 400



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 40/137 (29%), Positives = 51/137 (37%), Gaps = 32/137 (23%)

Query: 724 CACNGHSETC--DPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSC 781
           C CN H+  C  D     C C  NT GP C KC   Y G   +  S      P P G++ 
Sbjct: 297 CKCNLHATVCVYDNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSY----LPIPKGTAN 352

Query: 782 AVVPKTKEV---VCTN----CPTGTT---GKRCELCDDGYFGDPLGRNGPVRLCRLCQCS 831
             +P    +   VC N    C  G T     RC LC   Y G          LC   +C 
Sbjct: 353 TCIPSISSIGTNVCDNELLHCQNGGTCHNNVRC-LCPAAYTG---------ILCEKLRCE 402

Query: 832 DNIDPNAVGNCNRLTGE 848
           +       G+C   +G+
Sbjct: 403 E------AGSCGSDSGQ 413



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 33/109 (30%), Positives = 38/109 (34%), Gaps = 26/109 (23%)

Query: 884 CNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGAC---------DPGFY---------- 924
           C CNL+ T+    +       CEC  + TG DCG C          PG Y          
Sbjct: 297 CKCNLHATVCVYDNSKLT---CECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANT 353

Query: 925 --NLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCE--RCE 969
                S  G   CD   L   NG       +C C    TG  CE  RCE
Sbjct: 354 CIPSISSIGTNVCDNELLHCQNGGTCHNNVRCLCPAAYTGILCEKLRCE 402



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 34/124 (27%), Positives = 49/124 (39%), Gaps = 34/124 (27%)

Query: 923  FYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFG------ 976
            FY +   +   RC C+ L +T    D     CEC+   TG  C +C+ N+ G        
Sbjct: 285  FYAISDIKVRGRCKCN-LHATVCVYDNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSY 343

Query: 977  ---PEG----CKP---------CD-----CHPEGSLSLQCKDDGRCECREGFVGNRCD-- 1013
               P+G    C P         CD     C   G+    C ++ RC C   + G  C+  
Sbjct: 344  LPIPKGTANTCIPSISSIGTNVCDNELLHCQNGGT----CHNNVRCLCPAAYTGILCEKL 399

Query: 1014 QCEE 1017
            +CEE
Sbjct: 400  RCEE 403


>gi|164414437 netrin G1 isoform 2 [Homo sapiens]
          Length = 480

 Score =  140 bits (353), Expect = 1e-32
 Identities = 93/296 (31%), Positives = 136/296 (45%), Gaps = 32/296 (10%)

Query: 68  TCGTPPEEYCVQTGVTGVTKSCHL-CDAGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAG 126
           TCG PPE +C      G    C+  CDA  P L H    + D+  +  +T+WQS T    
Sbjct: 71  TCGDPPETFCAM----GNPYMCNNECDASTPELAHPPELMFDFEGRHPSTFWQSATWK-- 124

Query: 127 VQYPS--SINLTLHLGKAFDIT-YVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCE 183
            +YP    +N+TL   K  ++T  + + F + RP+   + K       W PYQYY+  C 
Sbjct: 125 -EYPKPLQVNITLSWSKTIELTDNIVITFESGRPDQMILEKSLDYGRTWQPYQYYATDCL 183

Query: 184 NTYSKANRGFIRTGGDEQ-QALCTDEFSDISPLTGGNVAFST-----------LEGRPSA 231
           + +    +           + +CT+E+S         + F             L    S 
Sbjct: 184 DAFHMDPKSVKDLSQHTVLEIICTEEYSTGYTTNSKIIHFEIKDRFAFFAGPRLRNMASL 243

Query: 232 YN-FDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNG 290
           Y   D +  L+++ T TD+R+ L  L     E+F D   L  Y+YAISD  V GRCKCN 
Sbjct: 244 YGQLDTTKKLRDFFTVTDLRIRL--LRPAVGEIFVDELHLARYFYAISDIKVRGRCKCNL 301

Query: 291 HASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRAT-----AESASECLP 341
           HA+ C+ +   KL C C+HNT G DC KC   +  RPW   +       +A+ C+P
Sbjct: 302 HATVCVYDN-SKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIP 356



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 22/69 (31%), Positives = 28/69 (40%), Gaps = 6/69 (8%)

Query: 724 CACNGHSETC--DPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSC 781
           C CN H+  C  D     C C  NT GP C KC   Y G   +  S      P P G++ 
Sbjct: 297 CKCNLHATVCVYDNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSY----LPIPKGTAN 352

Query: 782 AVVPKTKEV 790
             +P    +
Sbjct: 353 TCIPSISSI 361



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 14/40 (35%), Positives = 19/40 (47%), Gaps = 3/40 (7%)

Query: 884 CNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGF 923
           C CNL+ T+    +       CEC  + TG DCG C   +
Sbjct: 297 CKCNLHATVCVYDNSKLT---CECEHNTTGPDCGKCKKNY 333


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,220,370
Number of Sequences: 37866
Number of extensions: 3393577
Number of successful extensions: 24807
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 203
Number of HSP's successfully gapped in prelim test: 1031
Number of HSP's that attempted gapping in prelim test: 11940
Number of HSP's gapped (non-prelim): 5729
length of query: 1609
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1493
effective length of database: 13,855,062
effective search space: 20685607566
effective search space used: 20685607566
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.