Search of human proteins with 145275213

Search of human proteins with 145275213

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|145275213 coagulation factor XII precursor [Homo sapiens]
         (615 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|145275213 coagulation factor XII precursor [Homo sapiens]         1334   0.0  
gi|4504383 HGF activator preproprotein [Homo sapiens]                 459   e-129
gi|4505861 plasminogen activator, tissue isoform 1 preproprotein...   274   2e-73
gi|222537759 plasminogen activator, urokinase isoform 2 [Homo sa...   254   2e-67
gi|4505863 plasminogen activator, urokinase isoform 1 preproprot...   254   2e-67
gi|4758502 hyaluronan binding protein 2 preproprotein [Homo sapi...   249   4e-66
gi|4505881 plasminogen [Homo sapiens]                                 215   1e-55
gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens]               199   8e-51
gi|14702169 plasminogen activator, tissue isoform 3 preproprotei...   186   4e-47
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   177   3e-44
gi|117956391 protease, serine, 33 [Homo sapiens]                      164   2e-40
gi|33695155 hepsin [Homo sapiens]                                     164   2e-40
gi|4504481 hepsin [Homo sapiens]                                      164   2e-40
gi|58218970 protease, serine, 36 [Homo sapiens]                       163   5e-40
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          163   5e-40
gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ...   162   6e-40
gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo ...   162   6e-40
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          161   1e-39
gi|187761337 transmembrane protease, serine 11B [Homo sapiens]        160   3e-39
gi|148613878 acrosin precursor [Homo sapiens]                         156   5e-38
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           156   5e-38
gi|4506153 prostasin preproprotein [Homo sapiens]                     155   8e-38
gi|4503627 coagulation factor XI precursor [Homo sapiens]             155   1e-37
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         154   2e-37
gi|148231605 ovochymase 2 [Homo sapiens]                              154   3e-37
gi|32698940 transmembrane protease, serine 12 [Homo sapiens]          152   9e-37
gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]           152   1e-36
gi|11415040 matriptase [Homo sapiens]                                 151   2e-36
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             150   3e-36
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           150   4e-36

>gi|145275213 coagulation factor XII precursor [Homo sapiens]
          Length = 615

 Score = 1334 bits (3452), Expect = 0.0
 Identities = 615/615 (100%), Positives = 615/615 (100%)

Query: 1   MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHK 60
           MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHK
Sbjct: 1   MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHK 60

Query: 61  CTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCL 120
           CTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCL
Sbjct: 61  CTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCL 120

Query: 121 CPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRT 180
           CPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRT
Sbjct: 121 CPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRT 180

Query: 181 NPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQP 240
           NPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQP
Sbjct: 181 NPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQP 240

Query: 241 WASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQ 300
           WASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQ
Sbjct: 241 WASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQ 300

Query: 301 AAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCG 360
           AAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCG
Sbjct: 301 AAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCG 360

Query: 361 QRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAP 420
           QRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAP
Sbjct: 361 QRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAP 420

Query: 421 EDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSP 480
           EDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSP
Sbjct: 421 EDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSP 480

Query: 481 YVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGS 540
           YVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGS
Sbjct: 481 YVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGS 540

Query: 541 SILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYT 600
           SILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYT
Sbjct: 541 SILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYT 600

Query: 601 DVAYYLAWIREHTVS 615
           DVAYYLAWIREHTVS
Sbjct: 601 DVAYYLAWIREHTVS 615


>gi|4504383 HGF activator preproprotein [Homo sapiens]
          Length = 655

 Score =  459 bits (1181), Expect = e-129
 Identities = 239/607 (39%), Positives = 326/607 (53%), Gaps = 65/607 (10%)

Query: 21  PPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHKCTHKGRPGPQPWCATTPNFD 80
           PP   P     +A+     LT  G PC FPF+Y  ++ H CT +G    + WCATT N+D
Sbjct: 86  PPRAVPSSSSPQAQ----ALTEDGRPCRFPFRYGGRMLHACTSEGS-AHRKWCATTHNYD 140

Query: 81  QDQRWGYCLEPKK------VKDHCSKHSPCQKGGTCVNM--PSGPHCLCPQHLTGNHCQK 132
           +D+ WGYC+E           D C+   PC  GG+C N   P   HC CP+  TG  C  
Sbjct: 141 RDRAWGYCVEATPPPGGPAALDPCAS-GPCLNGGSCSNTQDPQSYHCSCPRAFTGKDCGT 199

Query: 133 EKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRTNPCLHGGRC--L 190
           EKCF+     +    + W R  Q  V +C+C G    C+     AC ++PCL+GG C  +
Sbjct: 200 EKCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGTRHTACLSSPCLNGGTCHLI 259

Query: 191 EVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQPWASEATYRNV 250
              G  +C CP G+ G  C+++    C+ G G  YRG+A T+ SG  C  W S+  Y+ +
Sbjct: 260 VATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGLSCLAWNSDLLYQEL 319

Query: 251 TAEQ---ARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQAAPPTPV 307
             +    A   GLG HA+CRNPDND RPWC+V+    LSWEYC L  C++ T+       
Sbjct: 320 HVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWEYCRLEACESLTRV------ 373

Query: 308 SPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCGQRLRKSL 367
             +L   L+   P P  P                             G  +CG+R +K  
Sbjct: 374 --QLSPDLLATLPEPASP-----------------------------GRQACGRRHKKRT 402

Query: 368 SSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVL 427
               R++GG  +L G+HP++AA+Y G SFCAGSL+  CWV++AAHC    P  + ++VVL
Sbjct: 403 FLRPRIIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVL 462

Query: 428 GQERRNHSCEPCQTLAVRSY---RLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQP 484
           GQ   N + +  QT  +  Y    L+  F+P    HDL L+RL++  D  CA  S +VQP
Sbjct: 463 GQHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSD--HDLVLIRLKKKGD-RCATRSQFVQP 519

Query: 485 VCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILP 544
           +CLP   +       CQ+AGWGH  E    Y+S L+EA VP ++  +CS+P+V+G+ I P
Sbjct: 520 ICLPEPGSTFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISP 579

Query: 545 GMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAY 604
            MLCAG+ +  +DACQGDSGGPL CE         L GIISWG GCG  +KPGVYT VA 
Sbjct: 580 NMLCAGYFDCKSDACQGDSGGPLACEKNGV---AYLYGIISWGDGCGRLHKPGVYTRVAN 636

Query: 605 YLAWIRE 611
           Y+ WI +
Sbjct: 637 YVDWIND 643


>gi|4505861 plasminogen activator, tissue isoform 1 preproprotein
           [Homo sapiens]
          Length = 562

 Score =  274 bits (700), Expect = 2e-73
 Identities = 171/523 (32%), Positives = 245/523 (46%), Gaps = 49/523 (9%)

Query: 135 CFEPQLLRFFHKNEIWYRT--EQAAVARCQCKGPDAHCQRLASQACRTNPCLHGGRCLEV 192
           C + +    + +++ W R       V  C C    A C  +  ++C    C +GG C + 
Sbjct: 41  CRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQA 100

Query: 193 --EGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQPWASEATYRNV 250
                 +C CP G+ G  C++DT+A+CY+ +G+SYRG   T  SGA C  W S A  +  
Sbjct: 101 LYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKP 160

Query: 251 TA---EQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQ----------- 296
            +     A   GLG H +CRNPD D +PWC+V    + S E+C    C            
Sbjct: 161 YSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNG 220

Query: 297 -----TPTQAAPPTPVSPRLHVPLMPAQPAPPKPQPTT---------RTPPQSQTPGALP 342
                T +         P   + L+        P             R P     P    
Sbjct: 221 SAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHV 280

Query: 343 AKREQPPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHS------- 395
            K  +      + P      LR+      R+ GGL A   +HP+ AA++  H        
Sbjct: 281 LKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERF 340

Query: 396 FCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSP 455
            C G LI+ CW+L+AAHC Q+R  P  LTV+LG+  R    E  Q   V  Y +H+ F  
Sbjct: 341 LCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDD 400

Query: 456 VSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEY 515
            +Y +D+ALL+L+ D+   CA  S  V+ VCLP    +  + T C+++G+G     +  Y
Sbjct: 401 DTYDNDIALLQLKSDS-SRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFY 459

Query: 516 ASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGG------TDACQGDSGGPLVC 569
           +  L+EA V      RC++  +   ++   MLCAG    G       DACQGDSGGPLVC
Sbjct: 460 SERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVC 519

Query: 570 EDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREH 612
            +   + R+TL GIISWG GCG ++ PGVYT V  YL WIR++
Sbjct: 520 LN---DGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDN 559



 Score =  100 bits (250), Expect = 3e-21
 Identities = 72/224 (32%), Positives = 89/224 (39%), Gaps = 46/224 (20%)

Query: 104 CQKGGTCVNMP--SGPHCLCPQHLTGNHCQ---KEKCFEPQLLRFFHKNEIWYRTEQAAV 158
           C  GGTC      S   C CP+   G  C+   +  C+E Q + +      W   E  A 
Sbjct: 91  CFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISY---RGTWSTAESGA- 146

Query: 159 ARCQCKGPDAHCQRLASQACRTNPCLHGGRC-----LEVEGHRLCHCPVG---------- 203
                      C    S A    P  + GR      L +  H  C  P            
Sbjct: 147 ----------ECTNWNSSALAQKP--YSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFK 194

Query: 204 ---YTGAFCDV----DTKASCYDGRGLSYRGLARTTLSGAPCQPWASEATYRNVTAEQ-- 254
              Y+  FC      +  + CY G G +YRG    T SGA C PW S      V   Q  
Sbjct: 195 AGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNP 254

Query: 255 -ARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQT 297
            A+  GLG H +CRNPD D +PWC VL   RL+WEYCD+  C T
Sbjct: 255 SAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCST 298


>gi|222537759 plasminogen activator, urokinase isoform 2 [Homo
           sapiens]
          Length = 414

 Score =  254 bits (648), Expect = 2e-67
 Identities = 153/446 (34%), Positives = 213/446 (47%), Gaps = 70/446 (15%)

Query: 183 CLHGGRCLE---VEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQ 239
           CL+GG C+          C+CP  + G  C++D   +CY+G G  YRG A T   G PC 
Sbjct: 16  CLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCL 75

Query: 240 PWAS----EATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQC 295
           PW S    + TY +     A   GLG H +CRNPDN  RPWC+V    +   + C +  C
Sbjct: 76  PWNSATVLQQTY-HAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDC 134

Query: 296 QTPTQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNG 355
                                                          A  ++P S     
Sbjct: 135 -----------------------------------------------ADGKKPSSPPEEL 147

Query: 356 PLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHS------FCAGSLIAPCWVLT 409
              CGQ   K+L    +++GG        P+ AA+Y  H        C GSLI+PCWV++
Sbjct: 148 KFQCGQ---KTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVIS 204

Query: 410 AAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSP--VSYQHDLALLRL 467
           A HC  D P  ED  V LG+ R N + +      V +  LH+ +S   +++ +D+ALL++
Sbjct: 205 ATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKI 264

Query: 468 QEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFL 527
           +   +G CA  S  +Q +CLPS    P   T C++ G+G +      Y   L+   V  +
Sbjct: 265 RSK-EGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLI 323

Query: 528 SLERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWG 587
           S   C  P  +GS +   MLCA   +  TD+CQGDSGGPLVC  Q    R+TL GI+SWG
Sbjct: 324 SHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQG---RMTLTGIVSWG 380

Query: 588 SGCGDRNKPGVYTDVAYYLAWIREHT 613
            GC  ++KPGVYT V+++L WIR HT
Sbjct: 381 RGCALKDKPGVYTRVSHFLPWIRSHT 406



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 17/40 (42%), Positives = 22/40 (55%), Gaps = 6/40 (15%)

Query: 104 CQKGGTCVNMP--SGPH-CLCPQHLTGNHCQKEK---CFE 137
           C  GGTCV+    S  H C CP+   G HC+ +K   C+E
Sbjct: 16  CLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYE 55


>gi|4505863 plasminogen activator, urokinase isoform 1 preproprotein
           [Homo sapiens]
          Length = 431

 Score =  254 bits (648), Expect = 2e-67
 Identities = 153/446 (34%), Positives = 213/446 (47%), Gaps = 70/446 (15%)

Query: 183 CLHGGRCLE---VEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQ 239
           CL+GG C+          C+CP  + G  C++D   +CY+G G  YRG A T   G PC 
Sbjct: 33  CLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCL 92

Query: 240 PWAS----EATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQC 295
           PW S    + TY +     A   GLG H +CRNPDN  RPWC+V    +   + C +  C
Sbjct: 93  PWNSATVLQQTY-HAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDC 151

Query: 296 QTPTQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNG 355
                                                          A  ++P S     
Sbjct: 152 -----------------------------------------------ADGKKPSSPPEEL 164

Query: 356 PLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHS------FCAGSLIAPCWVLT 409
              CGQ   K+L    +++GG        P+ AA+Y  H        C GSLI+PCWV++
Sbjct: 165 KFQCGQ---KTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVIS 221

Query: 410 AAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSP--VSYQHDLALLRL 467
           A HC  D P  ED  V LG+ R N + +      V +  LH+ +S   +++ +D+ALL++
Sbjct: 222 ATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKI 281

Query: 468 QEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFL 527
           +   +G CA  S  +Q +CLPS    P   T C++ G+G +      Y   L+   V  +
Sbjct: 282 RSK-EGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLI 340

Query: 528 SLERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWG 587
           S   C  P  +GS +   MLCA   +  TD+CQGDSGGPLVC  Q    R+TL GI+SWG
Sbjct: 341 SHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQG---RMTLTGIVSWG 397

Query: 588 SGCGDRNKPGVYTDVAYYLAWIREHT 613
            GC  ++KPGVYT V+++L WIR HT
Sbjct: 398 RGCALKDKPGVYTRVSHFLPWIRSHT 423



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 17/40 (42%), Positives = 22/40 (55%), Gaps = 6/40 (15%)

Query: 104 CQKGGTCVNMP--SGPH-CLCPQHLTGNHCQKEK---CFE 137
           C  GGTCV+    S  H C CP+   G HC+ +K   C+E
Sbjct: 33  CLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYE 72


>gi|4758502 hyaluronan binding protein 2 preproprotein [Homo
           sapiens]
          Length = 560

 Score =  249 bits (637), Expect = 4e-66
 Identities = 182/542 (33%), Positives = 251/542 (46%), Gaps = 103/542 (19%)

Query: 102 SPCQKGGTCVNMPSGPHCLCPQHLTGNHCQKEK-------CFEPQLLRFFHKNEIWYRTE 154
           +PC+ GG C+   S   C C    +GN CQK +       C   Q L           T+
Sbjct: 80  NPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPCGRGQCLI----------TQ 129

Query: 155 QAAVARCQCKGP--DAHCQRLASQACRTNPCLHGGRCLEVEGHR--LCHCPVGYTGAFCD 210
                RC CK P     C ++    CR NPC +G  C   +      C CP  + G FC+
Sbjct: 130 SPPYYRCVCKHPYTGPSCSQVVP-VCRPNPCQNGATCSRHKRRSKFTCACPDQFKGKFCE 188

Query: 211 VDTKASCYDGRGLSYRGLARTTLSGAPCQPWASEATYR---NVTAEQARNWGLGGHAFCR 267
           + +   CY G G SYRG    T++   C  W S    +   N+  E A   G+G H FCR
Sbjct: 189 IGSD-DCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGIGEHNFCR 247

Query: 268 NPDNDIRPWCFV-LNRDRLSWEYCDLAQCQTPTQAAPPTPVSPRLHVPLMPAQPAPPKPQ 326
           NPD D +PWCF+ +  D++ WEYCD++ C     A P    SP                +
Sbjct: 248 NPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEE--SPT---------------E 290

Query: 327 PTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPY 386
           P+T+ P                      G  SCG +   +   + R+ GG  +  G HP+
Sbjct: 291 PSTKLP----------------------GFDSCG-KTEIAERKIKRIYGGFKSTAGKHPW 327

Query: 387 IAALY----------WGHSFCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSC 436
            A+L            GH FC G+LI PCWVLTAAHC   +     L VVLG +      
Sbjct: 328 QASLQSSLPLTISMPQGH-FCGGALIHPCWVLTAAHCTDIK--TRHLKVVLGDQDLKK-- 382

Query: 437 EPCQTLAVRSYRLHEAFSPVSY-------QHDLALLRLQEDADGSCALLSPYVQPVCLPS 489
              +    +S+R+ + F    Y        +D+ALL+L +  DG CAL S YV+ VCLP 
Sbjct: 383 ---EEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKL-KPVDGHCALESKYVKTVCLPD 438

Query: 490 GAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCA 549
           G+  PS +  C ++GWG    G  + +  L +A+V  ++   C++  ++   I   M+CA
Sbjct: 439 GSF-PSGSE-CHISGWGVTETG--KGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICA 494

Query: 550 GFLE-GGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAW 608
           G L+  G D CQGDSGGPL CE         + GI+SWG  CG R  PGVYT V  +L W
Sbjct: 495 GNLQKPGQDTCQGDSGGPLTCEKDGT---YYVYGIVSWGLECGKR--PGVYTQVTKFLNW 549

Query: 609 IR 610
           I+
Sbjct: 550 IK 551



 Score = 37.0 bits (84), Expect = 0.054
 Identities = 22/84 (26%), Positives = 36/84 (42%), Gaps = 4/84 (4%)

Query: 142 RFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRTNPCLHGGRCLEVEGHRLCHCP 201
           ++ +  E + + E  +      + PD +     +  C+ NPC HGG CL       C C 
Sbjct: 41  QYDYSYEDYNQEENTSSTLTHAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCL 100

Query: 202 VGYTGAFCDVDTKASCYD---GRG 222
             ++G  C    + +C D   GRG
Sbjct: 101 APFSGNKCQ-KVQNTCKDNPCGRG 123


>gi|4505881 plasminogen [Homo sapiens]
          Length = 810

 Score =  215 bits (547), Expect = 1e-55
 Identities = 194/673 (28%), Positives = 273/673 (40%), Gaps = 145/673 (21%)

Query: 61  CTHKGRPGPQPWCATTPNFDQDQRWGYC--LEPKKVKDHCS------KHSPCQKGGTCVN 112
           C +       PWC TT   D ++R+ YC  LE ++   HCS      K S    G  C  
Sbjct: 152 CRNPDNDPQGPWCYTT---DPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQA 208

Query: 113 MPS-GPHC--LCPQHLTGNHCQKEKCFEP--QLLRFFHKNEIWYRTEQAAVARCQCKGPD 167
             S  PH     P      + +K  C  P  +L  +    +   R E   + RC    P 
Sbjct: 209 WDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTPPPS 268

Query: 168 AH-------------------------CQRLASQACRTN-------PC--LHGGRCLEVE 193
           +                          CQ  ++Q   T+       PC  L    C   +
Sbjct: 269 SGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPD 328

Query: 194 GHRLCHCPVGYTGA---FCDVDTKAS----------------------CYDGRGLSYRGL 228
           G R   C    +     +C + +  S                      CY G G SYRG 
Sbjct: 329 GKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGT 388

Query: 229 ARTTLSGAPCQPWASEATYRNV-TAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSW 287
           + TT +G  CQ W+S   +R+  T E   N GL  + +CRNPD D  PWCF  +   + W
Sbjct: 389 SSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMN-YCRNPDADKGPWCFTTDPS-VRW 446

Query: 288 EYCDLAQC---QTPTQAAPPTPVSPRLHVPL----------------------MPAQP-A 321
           EYC+L +C   +    A PP  + P +  P                        P Q  A
Sbjct: 447 EYCNLKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWA 506

Query: 322 PPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGP-----------------------LS 358
             +P   +   P++     L     + P     GP                         
Sbjct: 507 AQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFD 566

Query: 359 CGQRLRKSLSSMTRVVGGLVALRGAHPYIAALY--WGHSFCAGSLIAPCWVLTAAHCLQD 416
           CG+   +      RVVGG VA   + P+  +L   +G  FC G+LI+P WVLTAAHCL+ 
Sbjct: 567 CGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEK 626

Query: 417 RPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCA 476
            P P    V+LG  +  +     Q + V    L         + D+ALL+L      S A
Sbjct: 627 SPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPT------RKDIALLKLS-----SPA 675

Query: 477 LLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPD 536
           +++  V P CLPS     ++ T C + GWG + +G    A  L+EAQ+P +  + C+  +
Sbjct: 676 VITDKVIPACLPSPNYVVADRTECFITGWG-ETQGTFG-AGLLKEAQLPVIENKVCNRYE 733

Query: 537 VHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKP 596
                +    LCAG L GGTD+CQGDSGGPLVC +   + +  LQG+ SWG GC   NKP
Sbjct: 734 FLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFE---KDKYILQGVTSWGLGCARPNKP 790

Query: 597 GVYTDVAYYLAWI 609
           GVY  V+ ++ WI
Sbjct: 791 GVYVRVSRFVTWI 803



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 29/84 (34%), Positives = 49/84 (58%), Gaps = 4/84 (4%)

Query: 215 ASCYDGRGLSYRGLARTTLSGAPCQPWASEATYR-NVTAEQARNWGLGGHAFCRNPDNDI 273
           + C  G G +YRG    T +G  CQ W+S + +R   +     + GL  + +CRNPDND 
Sbjct: 101 SECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEEN-YCRNPDNDP 159

Query: 274 R-PWCFVLNRDRLSWEYCDLAQCQ 296
           + PWC+  + ++  ++YCD+ +C+
Sbjct: 160 QGPWCYTTDPEK-RYDYCDILECE 182


>gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens]
          Length = 2040

 Score =  199 bits (505), Expect = 8e-51
 Identities = 204/720 (28%), Positives = 289/720 (40%), Gaps = 151/720 (20%)

Query: 1    MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEE----------HTVVLTVTGEPCH-- 48
            M + LL    +V + ST  +P  EAP E+    ++           T+  T+TG  C   
Sbjct: 1354 MESTLLTTPTVVPVPST-ELPSEEAPTENSTGVQDCYRGDGQSYRGTLSTTITGRTCQSW 1412

Query: 49   --FPFQYHRQ--LYHK---CTHKGRPGP----QPWCATTPNFDQDQRWGYC--------- 88
                  +HR+  LY+     T      P    +PWC T    D   RW YC         
Sbjct: 1413 SSMTPHWHRRIPLYYPNAGLTRNYCRNPDAEIRPWCYT---MDPSVRWEYCNLTRCPVTE 1469

Query: 89   --------LEPKKVKDHCSKHSPCQKGGTCVNMPSGP----HCLCPQHLTGNHCQKEKCF 136
                    + P    +  S+ +P +K     +   G       +    +TG  CQ     
Sbjct: 1470 SSVLTTPTVAPVPSTEAPSEQAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWSSM 1529

Query: 137  EPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRTNPCLHGG-----RCLE 191
             P   +   +N        A +    C+ PD+  Q        T+PC+        +C E
Sbjct: 1530 IPHWHQRTPENY-----PNAGLTENYCRNPDSGKQ---PWCYTTDPCVRWEYCNLTQCSE 1581

Query: 192  VEGHRLCHCPVGYTGAFCDVDTKAS----------CYDGRGLSYRGLARTTLSGAPCQPW 241
             E   L   P        +  ++A+          CY G G SYRG   TT++G  CQ W
Sbjct: 1582 TESGVL-ETPTVVPVPSMEAHSEAAPTEQTPVVRQCYHGNGQSYRGTFSTTVTGRTCQSW 1640

Query: 242  ASEATYRNV-TAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTP-- 298
            +S   +R+  T E   N GL  + +CRNPD D  PWCF ++   + WEYC+L +C     
Sbjct: 1641 SSMTPHRHQRTPENYPNDGLTMN-YCRNPDADTGPWCFTMDPS-IRWEYCNLTRCSDTEG 1698

Query: 299  TQAAPPTPVS-PRLHVPL----------------------MPAQP-APPKPQPTTRTPPQ 334
            T  APPT +  P L  P                        P Q  A  +P   +   P 
Sbjct: 1699 TVVAPPTVIQVPSLGPPSEQDCMFGNGKGYRGKKATTVTGTPCQEWAAQEPHRHSTFIPG 1758

Query: 335  SQTPGALPAKREQPPSLTRNGP-----------------------LSCGQRLRKSLSSMT 371
            +     L     + P    NGP                         CG+   +      
Sbjct: 1759 TNKWAGLEKNYCRNPDGDINGPWCYTMNPRKLFDYCDIPLCASSSFDCGKPQVEPKKCPG 1818

Query: 372  RVVGGLVALRGAHPYIAALY--WGHSFCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQ 429
             +VGG VA   + P+  +L   +G  FC G+LI+P WVLTAAHCL+    P    V+LG 
Sbjct: 1819 SIVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAAHCLKKSSRPSSYKVILGA 1878

Query: 430  ERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPS 489
             +  +     Q + V    L         Q D+ALL+L        A+++  V P CLPS
Sbjct: 1879 HQEVNLESHVQEIEVSRLFLEPT------QADIALLKLSRP-----AVITDKVMPACLPS 1927

Query: 490  GAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCA 549
                 +  T C + GWG + +G       L+EAQ+  +  E C+    H   I     CA
Sbjct: 1928 PDYMVTARTECYITGWG-ETQGTFG-TGLLKEAQLLVIENEVCN----HYKYI-----CA 1976

Query: 550  GFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWI 609
              L  GTD+CQGDSGGPLVC +   + +  LQG+ SWG GC   NKPGVY  V+ ++ WI
Sbjct: 1977 EHLARGTDSCQGDSGGPLVCFE---KDKYILQGVTSWGLGCARPNKPGVYARVSRFVTWI 2033



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 77/288 (26%), Positives = 109/288 (37%), Gaps = 55/288 (19%)

Query: 70   QPWCATTPNFDQDQRWGYC-----------------LEPKKVKDHCSKHSPCQKGGTCVN 112
            +PWC T    D   RW YC                 + P    +  S+ +P ++     +
Sbjct: 1111 RPWCYT---MDPSVRWEYCNLTQCLVTESSVLATLTVVPDPSTEASSEEAPTEQSPGVQD 1167

Query: 113  MPSGP----HCLCPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDA 168
               G            +TG  CQ      P     +H+    Y      + R  C+ PDA
Sbjct: 1168 CYHGDGQSYRGSFSTTVTGRTCQSWSSMTPH----WHQRTTEYYPN-GGLTRNYCRNPDA 1222

Query: 169  HCQRLASQACRT-NPCLHGGRCLEVEGHRLCHCPVGYTGAFC------------DVDTKA 215
                  S  C T +P +    C       L  CPV  +                   T  
Sbjct: 1223 EI----SPWCYTMDPNVRWEYC------NLTQCPVTESSVLATSTAVSEQAPTEQSPTVQ 1272

Query: 216  SCYDGRGLSYRGLARTTLSGAPCQPWASEAT-YRNVTAEQARNWGLGGHAFCRNPDNDIR 274
             CY G G SYRG   TT++G  CQ W+S    +   T E   N GL  + +CRNPD +IR
Sbjct: 1273 DCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRN-YCRNPDAEIR 1331

Query: 275  PWCFVLNRDRLSWEYCDLAQCQTPTQAAPPTPVSPRLHVPLMPAQPAP 322
            PWC+ ++   + WEYC+L QC         TP    +    +P++ AP
Sbjct: 1332 PWCYTMD-PSVRWEYCNLTQCPVMESTLLTTPTVVPVPSTELPSEEAP 1378



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 98/376 (26%), Positives = 133/376 (35%), Gaps = 86/376 (22%)

Query: 17   TLSIPPWEAPKEHKYKAEE----------HTVVLTVTGEPCHF-----PFQYHRQ----- 56
            +L  P  +AP E +   +E           T  +TVTG  C       P  + R      
Sbjct: 921  SLEAPSEQAPTEQRPGVQECYHGNGQSYQGTYFITVTGRTCQAWSSMTPHSHSRTPAYYP 980

Query: 57   ---LYHKCTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNM 113
               L         P   PWC TT   D   RW YC   +     CS           V +
Sbjct: 981  NAGLIKNYCRNPDPVAAPWCYTT---DPSVRWEYCNLTR-----CSDAEWTAFVPPNVIL 1032

Query: 114  PSGPHCLCPQHLTGNHCQKEKCFEP--QLLRFFHKNEIWYRTEQA--------------- 156
                     Q LT      + C+    Q  R  +   +  RT QA               
Sbjct: 1033 APSLEAFFEQALTEETPGVQDCYYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQHSRTPEN 1092

Query: 157  ----AVARCQCKGPDAHCQRLA---SQACRTNPCLHGGRCLEVEGHRLCHCPVGYTGAFC 209
                 + R  C+ PDA  +        + R   C +  +CL  E   L    V       
Sbjct: 1093 YPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYC-NLTQCLVTESSVLATLTV-----VP 1146

Query: 210  DVDTKAS--------------CYDGRGLSYRGLARTTLSGAPCQPWASEAT-YRNVTAEQ 254
            D  T+AS              CY G G SYRG   TT++G  CQ W+S    +   T E 
Sbjct: 1147 DPSTEASSEEAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEY 1206

Query: 255  ARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQAAPPTPVSPRLHVP 314
              N GL  + +CRNPD +I PWC+ ++   + WEYC+L QC        P   S  L   
Sbjct: 1207 YPNGGLTRN-YCRNPDAEISPWCYTMD-PNVRWEYCNLTQC--------PVTESSVLATS 1256

Query: 315  LMPAQPAPPKPQPTTR 330
               ++ AP +  PT +
Sbjct: 1257 TAVSEQAPTEQSPTVQ 1272



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 48/119 (40%), Positives = 65/119 (54%), Gaps = 12/119 (10%)

Query: 217 CYDGRGLSYRGLARTTLSGAPCQPWASEATYR-NVTAEQARNWGLGGHAFCRNPDNDIRP 275
           CY G G SYRG   TT++G  CQ W+S   ++ N T E   N GL  + +CRNPD    P
Sbjct: 28  CYHGDGQSYRGTYSTTVTGRTCQAWSSMTPHQHNRTTENYPNAGLIMN-YCRNPDAVAAP 86

Query: 276 WCFVLNRDRLSWEYCDLAQCQTP--TQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTP 332
           +C+  +   + WEYC+L QC     T  APPT V+P      +P+  AP +  PT + P
Sbjct: 87  YCYTRD-PGVRWEYCNLTQCSDAEGTAVAPPT-VTP------VPSLEAPSEQAPTEQRP 137



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 50/156 (32%), Positives = 75/156 (48%), Gaps = 14/156 (8%)

Query: 217  CYDGRGLSYRGLARTTLSGAPCQPWASEATYRNV-TAEQARNWGLGGHAFCRNPDNDIRP 275
            CY   G SYRG   TT++G  CQ W+S   +++  T E   N GL  + +CRNPD +IRP
Sbjct: 1054 CYYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQHSRTPENYPNAGLTRN-YCRNPDAEIRP 1112

Query: 276  WCFVLNRDRLSWEYCDLAQCQTPTQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQS 335
            WC+ ++   + WEYC+L QC     +   T       + ++P     P  + ++   P  
Sbjct: 1113 WCYTMD-PSVRWEYCNLTQCLVTESSVLAT-------LTVVP----DPSTEASSEEAPTE 1160

Query: 336  QTPGALPAKREQPPSLTRNGPLSCGQRLRKSLSSMT 371
            Q+PG          S   +   +   R  +S SSMT
Sbjct: 1161 QSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMT 1196



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 47/119 (39%), Positives = 64/119 (53%), Gaps = 12/119 (10%)

Query: 217 CYDGRGLSYRGLARTTLSGAPCQPWASEATY-RNVTAEQARNWGLGGHAFCRNPDNDIRP 275
           CY G G SYRG   TT++G  CQ W+S   +  + T E   N GL  + +CRNPD    P
Sbjct: 142 CYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMN-YCRNPDAVAAP 200

Query: 276 WCFVLNRDRLSWEYCDLAQCQTP--TQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTP 332
           +C+  +   + WEYC+L QC     T  APPT V+P      +P+  AP +  PT + P
Sbjct: 201 YCYTRD-PGVRWEYCNLTQCSDAEGTAVAPPT-VTP------VPSLEAPSEQAPTEQRP 251



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 47/119 (39%), Positives = 64/119 (53%), Gaps = 12/119 (10%)

Query: 217 CYDGRGLSYRGLARTTLSGAPCQPWASEATY-RNVTAEQARNWGLGGHAFCRNPDNDIRP 275
           CY G G SYRG   TT++G  CQ W+S   +  + T E   N GL  + +CRNPD    P
Sbjct: 256 CYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMN-YCRNPDAVAAP 314

Query: 276 WCFVLNRDRLSWEYCDLAQCQTP--TQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTP 332
           +C+  +   + WEYC+L QC     T  APPT V+P      +P+  AP +  PT + P
Sbjct: 315 YCYTRD-PGVRWEYCNLTQCSDAEGTAVAPPT-VTP------VPSLEAPSEQAPTEQRP 365



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 47/119 (39%), Positives = 64/119 (53%), Gaps = 12/119 (10%)

Query: 217 CYDGRGLSYRGLARTTLSGAPCQPWASEATY-RNVTAEQARNWGLGGHAFCRNPDNDIRP 275
           CY G G SYRG   TT++G  CQ W+S   +  + T E   N GL  + +CRNPD    P
Sbjct: 370 CYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMN-YCRNPDAVAAP 428

Query: 276 WCFVLNRDRLSWEYCDLAQCQTP--TQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTP 332
           +C+  +   + WEYC+L QC     T  APPT V+P      +P+  AP +  PT + P
Sbjct: 429 YCYTRD-PGVRWEYCNLTQCSDAEGTAVAPPT-VTP------VPSLEAPSEQAPTEQRP 479



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 47/119 (39%), Positives = 64/119 (53%), Gaps = 12/119 (10%)

Query: 217 CYDGRGLSYRGLARTTLSGAPCQPWASEATY-RNVTAEQARNWGLGGHAFCRNPDNDIRP 275
           CY G G SYRG   TT++G  CQ W+S   +  + T E   N GL  + +CRNPD    P
Sbjct: 484 CYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMN-YCRNPDAVAAP 542

Query: 276 WCFVLNRDRLSWEYCDLAQCQTP--TQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTP 332
           +C+  +   + WEYC+L QC     T  APPT V+P      +P+  AP +  PT + P
Sbjct: 543 YCYTRD-PGVRWEYCNLTQCSDAEGTAVAPPT-VTP------VPSLEAPSEQAPTEQRP 593



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 47/119 (39%), Positives = 64/119 (53%), Gaps = 12/119 (10%)

Query: 217 CYDGRGLSYRGLARTTLSGAPCQPWASEATY-RNVTAEQARNWGLGGHAFCRNPDNDIRP 275
           CY G G SYRG   TT++G  CQ W+S   +  + T E   N GL  + +CRNPD    P
Sbjct: 598 CYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMN-YCRNPDAVAAP 656

Query: 276 WCFVLNRDRLSWEYCDLAQCQTP--TQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTP 332
           +C+  +   + WEYC+L QC     T  APPT V+P      +P+  AP +  PT + P
Sbjct: 657 YCYTRD-PGVRWEYCNLTQCSDAEGTAVAPPT-VTP------VPSLEAPSEQAPTEQRP 707



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 47/119 (39%), Positives = 64/119 (53%), Gaps = 12/119 (10%)

Query: 217 CYDGRGLSYRGLARTTLSGAPCQPWASEATY-RNVTAEQARNWGLGGHAFCRNPDNDIRP 275
           CY G G SYRG   TT++G  CQ W+S   +  + T E   N GL  + +CRNPD    P
Sbjct: 712 CYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMN-YCRNPDAVAAP 770

Query: 276 WCFVLNRDRLSWEYCDLAQCQTP--TQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTP 332
           +C+  +   + WEYC+L QC     T  APPT V+P      +P+  AP +  PT + P
Sbjct: 771 YCYTRD-PGVRWEYCNLTQCSDAEGTAVAPPT-VTP------VPSLEAPSEQAPTEQRP 821



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 46/119 (38%), Positives = 64/119 (53%), Gaps = 12/119 (10%)

Query: 217 CYDGRGLSYRGLARTTLSGAPCQPWASEATY-RNVTAEQARNWGLGGHAFCRNPDNDIRP 275
           CY G G SYRG   TT++G  CQ W+S   +  + T E   N GL  + +CRNPD    P
Sbjct: 826 CYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMN-YCRNPDPVAAP 884

Query: 276 WCFVLNRDRLSWEYCDLAQCQTP--TQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTP 332
           +C+  +   + WEYC+L QC     T  APPT ++P      +P+  AP +  PT + P
Sbjct: 885 YCYTRD-PSVRWEYCNLTQCSDAEGTAVAPPT-ITP------IPSLEAPSEQAPTEQRP 935


>gi|14702169 plasminogen activator, tissue isoform 3 preproprotein
           [Homo sapiens]
          Length = 516

 Score =  186 bits (473), Expect = 4e-47
 Identities = 108/268 (40%), Positives = 151/268 (56%), Gaps = 19/268 (7%)

Query: 358 SCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHS-------FCAGSLIAPCWVLTA 410
           +CG  LR+      R+ GGL A   +HP+ AA++  H         C G LI+ CW+L+A
Sbjct: 252 TCG--LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSA 309

Query: 411 AHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQED 470
           AHC Q+R  P  LTV+LG+  R    E  Q   V  Y +H+ F   +Y +D+ALL+L+ D
Sbjct: 310 AHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSD 369

Query: 471 ADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLE 530
           +   CA  S  V+ VCLP    +  + T C+++G+G     +  Y+  L+EA V      
Sbjct: 370 S-SRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSS 428

Query: 531 RCSAPDVHGSSILPGMLCAGFLEGG------TDACQGDSGGPLVCEDQAAERRLTLQGII 584
           RC++  +   ++   MLCAG    G       DACQGDSGGPLVC +   + R+TL GII
Sbjct: 429 RCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLN---DGRMTLVGII 485

Query: 585 SWGSGCGDRNKPGVYTDVAYYLAWIREH 612
           SWG GCG ++ PGVYT V  YL WIR++
Sbjct: 486 SWGLGCGQKDVPGVYTKVTNYLDWIRDN 513



 Score =  100 bits (250), Expect = 3e-21
 Identities = 72/224 (32%), Positives = 89/224 (39%), Gaps = 46/224 (20%)

Query: 104 CQKGGTCVNMP--SGPHCLCPQHLTGNHCQ---KEKCFEPQLLRFFHKNEIWYRTEQAAV 158
           C  GGTC      S   C CP+   G  C+   +  C+E Q + +      W   E  A 
Sbjct: 45  CFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISY---RGTWSTAESGA- 100

Query: 159 ARCQCKGPDAHCQRLASQACRTNPCLHGGRC-----LEVEGHRLCHCPVG---------- 203
                      C    S A    P  + GR      L +  H  C  P            
Sbjct: 101 ----------ECTNWNSSALAQKP--YSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFK 148

Query: 204 ---YTGAFCDV----DTKASCYDGRGLSYRGLARTTLSGAPCQPWASEATYRNVTAEQ-- 254
              Y+  FC      +  + CY G G +YRG    T SGA C PW S      V   Q  
Sbjct: 149 AGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNP 208

Query: 255 -ARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQT 297
            A+  GLG H +CRNPD D +PWC VL   RL+WEYCD+  C T
Sbjct: 209 SAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCST 252


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  177 bits (449), Expect = 3e-44
 Identities = 101/256 (39%), Positives = 143/256 (55%), Gaps = 17/256 (6%)

Query: 358 SCGQRLRKSLSSMTRVVGGLVALRGAHPYIAAL-YWGHSFCAGSLIAPCWVLTAAHCLQD 416
           +CG R   S    +R+VGG ++L    P+ A+L + G+  C GS+I P W++TAAHC+ D
Sbjct: 206 ACGHRRGYS----SRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYD 261

Query: 417 RPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCA 476
              P+  T+ +G      +  P  +  V     H  + P    +D+AL++L         
Sbjct: 262 LYLPKSWTIQVGLVSLLDN--PAPSHLVEKIVYHSKYKPKRLGNDIALMKL-----AGPL 314

Query: 477 LLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPD 536
             +  +QPVCLP+      +  +C  +GWG   +GA + +  L  A VP +S + C+  D
Sbjct: 315 TFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRD 374

Query: 537 VHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRL-TLQGIISWGSGCGDRNK 595
           V+G  I P MLCAG+L GG D+CQGDSGGPLVC+    ERRL  L G  S+G GC + NK
Sbjct: 375 VYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQ----ERRLWKLVGATSFGIGCAEVNK 430

Query: 596 PGVYTDVAYYLAWIRE 611
           PGVYT V  +L WI E
Sbjct: 431 PGVYTRVTSFLDWIHE 446


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  164 bits (416), Expect = 2e-40
 Identities = 108/263 (41%), Positives = 134/263 (50%), Gaps = 24/263 (9%)

Query: 358 SCGQRLRKSLSSMTRVVGGLVALRGAHPYIAAL-YWGHSFCAGSLIAPCWVLTAAHCLQD 416
           +CGQ    S     R+VGG     G  P+ A++ + G   C GSLIAP WVLTAAHC   
Sbjct: 27  ACGQPRMSS-----RIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPR 81

Query: 417 RPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCA 476
           R  P +  V LG  R   +     ++ VR   L   +S    + DLALL+L+        
Sbjct: 82  RALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVP---- 137

Query: 477 LLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGA--EEYASFLQEAQVPFLSLERCSA 534
            LS  VQPVCLP   ARP   T C+V GWG    G    E+   LQ  +VP L    C  
Sbjct: 138 -LSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRP-LQGVRVPLLDSRTCDG 195

Query: 535 PDVHGSS-------ILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWG 587
               G+        +LPG LCAG+ +G  DACQGDSGGPL C    +     L G++SWG
Sbjct: 196 LYHVGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGS---WVLVGVVSWG 252

Query: 588 SGCGDRNKPGVYTDVAYYLAWIR 610
            GC   N+PGVYT VA Y  WI+
Sbjct: 253 KGCALPNRPGVYTSVATYSPWIQ 275


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  164 bits (415), Expect = 2e-40
 Identities = 103/260 (39%), Positives = 137/260 (52%), Gaps = 21/260 (8%)

Query: 359 CGQRLRKSLSSMTRVVGGLVALRGAHPYIAAL-YWGHSFCAGSLIAPCWVLTAAHCLQDR 417
           CG+R       + R+VGG     G  P+  +L Y G   C GSL++  WVLTAAHC  +R
Sbjct: 153 CGRRKLP----VDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPER 208

Query: 418 PAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPV------SYQHDLALLRLQEDA 471
                   V        S    Q L V++   H  + P          +D+AL+ L    
Sbjct: 209 NRVLSRWRVFAGAVAQASPHGLQ-LGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPL 267

Query: 472 DGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGH-QFEGAEEYASFLQEAQVPFLSLE 530
                 L+ Y+QPVCLP+      +  +C V GWG+ Q+ G +  A  LQEA+VP +S +
Sbjct: 268 P-----LTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQ--AGVLQEARVPIISND 320

Query: 531 RCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAER-RLTLQGIISWGSG 589
            C+  D +G+ I P M CAG+ EGG DACQGDSGGP VCED  +   R  L GI+SWG+G
Sbjct: 321 VCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTG 380

Query: 590 CGDRNKPGVYTDVAYYLAWI 609
           C    KPGVYT V+ +  WI
Sbjct: 381 CALAQKPGVYTKVSDFREWI 400


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  164 bits (415), Expect = 2e-40
 Identities = 103/260 (39%), Positives = 137/260 (52%), Gaps = 21/260 (8%)

Query: 359 CGQRLRKSLSSMTRVVGGLVALRGAHPYIAAL-YWGHSFCAGSLIAPCWVLTAAHCLQDR 417
           CG+R       + R+VGG     G  P+  +L Y G   C GSL++  WVLTAAHC  +R
Sbjct: 153 CGRRKLP----VDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPER 208

Query: 418 PAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPV------SYQHDLALLRLQEDA 471
                   V        S    Q L V++   H  + P          +D+AL+ L    
Sbjct: 209 NRVLSRWRVFAGAVAQASPHGLQ-LGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPL 267

Query: 472 DGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGH-QFEGAEEYASFLQEAQVPFLSLE 530
                 L+ Y+QPVCLP+      +  +C V GWG+ Q+ G +  A  LQEA+VP +S +
Sbjct: 268 P-----LTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQ--AGVLQEARVPIISND 320

Query: 531 RCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAER-RLTLQGIISWGSG 589
            C+  D +G+ I P M CAG+ EGG DACQGDSGGP VCED  +   R  L GI+SWG+G
Sbjct: 321 VCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTG 380

Query: 590 CGDRNKPGVYTDVAYYLAWI 609
           C    KPGVYT V+ +  WI
Sbjct: 381 CALAQKPGVYTKVSDFREWI 400


>gi|58218970 protease, serine, 36 [Homo sapiens]
          Length = 855

 Score =  163 bits (412), Expect = 5e-40
 Identities = 118/293 (40%), Positives = 144/293 (49%), Gaps = 29/293 (9%)

Query: 335 SQTPGALPAKREQPPSLTRNGP--LSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYW 392
           S  PGA       P   T+  P  L CG+          R+VGG  A  G  P+  +L+ 
Sbjct: 15  SPIPGAFQDSALSP---TQEEPEDLDCGRP-----EPSARIVGGSNAQPGTWPWQVSLHH 66

Query: 393 GHS-FCAGSLIAPCWVLTAAHCLQDRPAPE---DLTVVLGQERRNHSCEPCQTLAVRSYR 448
           G    C GSLIAP WVL+AAHC       E   + +V+LG   ++   +   T AV +  
Sbjct: 67  GGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLLGVHSQDGPLDGAHTRAVAAIV 126

Query: 449 LHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQ 508
           +   +S V    DLALLRL      S A L P V PVCLP  + R    T C   GWG  
Sbjct: 127 VPANYSQVELGADLALLRL-----ASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDV 181

Query: 509 FEGAEEYASF-LQEAQVPFLSLERCSA------PDVHGSSILPGMLCAGFLEGGTDACQG 561
            E       + LQE ++  L    C        P      ILPGMLCAG+ EG  D CQG
Sbjct: 182 QEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQG 241

Query: 562 DSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREHTV 614
           DSGGPLVCE+     R    GI S+G GCG RN+PGV+T VA Y AWIRE  +
Sbjct: 242 DSGGPLVCEEGG---RWFQAGITSFGFGCGRRNRPGVFTAVATYEAWIREQVM 291



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 61/209 (29%), Positives = 89/209 (42%), Gaps = 26/209 (12%)

Query: 385 PYIAALYW-GHSFCAGSLIAPCWVLTAAHCLQDRPAPED---LTVVLGQERRNHSCEPCQ 440
           P++A ++  G   C G L+AP WVL A HC+  RP       + V LG+   +   +  Q
Sbjct: 602 PWLAEVHVAGDRVCTGILLAPGWVLAATHCVL-RPGSTTVPYIEVYLGRAGASSLPQGHQ 660

Query: 441 -TLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETTL 499
            +  V S RL +    +  +  LALL L    + S + L   + P  +P GA+       
Sbjct: 661 VSRLVISIRLPQ---HLGLRPPLALLELSSRVEPSPSALPICLHPAGIPPGAS------- 710

Query: 500 CQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGTDAC 559
           C V GW       E        A V  L+   C    ++   + PG LC  + EG  + C
Sbjct: 711 CWVLGW------KEPQDRVPVAAAVSILTQRICDC--LYQGILPPGTLCVLYAEGQENRC 762

Query: 560 QGDSGGPLVCEDQAAERRLTLQGIISWGS 588
           +  S  PL+C  Q  E    L G+   GS
Sbjct: 763 EMTSAPPLLC--QMTEGSWILVGMAVQGS 789



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 68/240 (28%), Positives = 96/240 (40%), Gaps = 25/240 (10%)

Query: 382 GAHPYIA-ALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPCQ 440
           GA P+ A  +  G   C G+L++  WVL  A C  D  + +     L   R      P +
Sbjct: 332 GAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWR---VLLPSR 388

Query: 441 TLAVRSYRL--HEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETT 498
             A R  RL  HE  S      DLALL+L+   +     LS   +PVCLP         +
Sbjct: 389 PRAERVARLVQHENAS-WDNASDLALLQLRTPVN-----LSAASRPVCLPHPEHYFLPGS 442

Query: 499 LCQVAGWGH----QFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLE- 553
            C++A WG        GA   A  L       L   + +A  + G    P  LC  + E 
Sbjct: 443 RCRLARWGRGEPALGPGALLEAELLGGWWCHCLYGRQGAAVPLPGDP--PHALCPAYQEK 500

Query: 554 GGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREHT 613
               +C  DS   L+C++   E    L GI  + SGC    +P  +  +  +  WI   T
Sbjct: 501 EEVGSCWNDSRWSLLCQE---EGTWFLAGIRDFPSGC---LRPRAFFPLQTHGPWISHVT 554


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  163 bits (412), Expect = 5e-40
 Identities = 96/250 (38%), Positives = 135/250 (54%), Gaps = 21/250 (8%)

Query: 369 SMTRVVGGLVALRGAHPYIAALYWGHSF-CAGSLIAPCWVLTAAHCLQDRPAPEDLTVVL 427
           S  R++GG  A  G+ P+  +L   ++  C GSLI   W+LTAAHC +    P D     
Sbjct: 183 SEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATS 242

Query: 428 GQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCL 487
           G      +  P   + VR+  +H  +   ++++D+AL+RL+          +  +  VCL
Sbjct: 243 GIS----TTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVT-----FTKDIHSVCL 293

Query: 488 PSGAARPSETTLCQVAGWGHQFEGAEEYASF----LQEAQVPFLSLERCSAPDVHGSSIL 543
           P+        +   V GWG     A+EYA      L++ QV  +S + C+AP  +  +IL
Sbjct: 294 PAATQNIPPGSTAYVTGWG-----AQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAIL 348

Query: 544 PGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVA 603
            GMLCAG  +GG DACQGDSGGPLV ED  + R   + GI+SWG  CG  +KPGVYT V 
Sbjct: 349 SGMLCAGVPQGGVDACQGDSGGPLVQED--SRRLWFIVGIVSWGDQCGLPDKPGVYTRVT 406

Query: 604 YYLAWIREHT 613
            YL WIR+ T
Sbjct: 407 AYLDWIRQQT 416


>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
           sapiens]
          Length = 418

 Score =  162 bits (411), Expect = 6e-40
 Identities = 92/257 (35%), Positives = 140/257 (54%), Gaps = 15/257 (5%)

Query: 358 SCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSF-CAGSLIAPCWVLTAAHCLQD 416
           SCG+R+     ++ R+  G++A + A P+ A+L + +   C  +LI+  W++TAAHC Q 
Sbjct: 174 SCGKRVVPL--NVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQK 231

Query: 417 RPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCA 476
              P   TV  G +       P     VR + +HE +   + ++D+A++++      S  
Sbjct: 232 YKNPHQWTVSFGTKIN----PPLMKRNVRRFIIHEKYRSAAREYDIAVVQVS-----SRV 282

Query: 477 LLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPD 536
             S  ++ +CLP  +A         + G+G  + G E     L+EA+V  +S + C  P 
Sbjct: 283 TFSDDIRQICLPEASASFQPNLTVHITGFGALYYGGESQND-LREARVKIISDDVCKQPQ 341

Query: 537 VHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKP 596
           V+G+ I PGM CAG++EG  DAC+GDSGGPLV  D   +    L GI+SWG  CG ++KP
Sbjct: 342 VYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRD--LKDTWYLIGIVSWGDNCGQKDKP 399

Query: 597 GVYTDVAYYLAWIREHT 613
           GVYT V YY  WI   T
Sbjct: 400 GVYTQVTYYRNWIASKT 416


>gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo
           sapiens]
          Length = 421

 Score =  162 bits (411), Expect = 6e-40
 Identities = 92/257 (35%), Positives = 140/257 (54%), Gaps = 15/257 (5%)

Query: 358 SCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSF-CAGSLIAPCWVLTAAHCLQD 416
           SCG+R+     ++ R+  G++A + A P+ A+L + +   C  +LI+  W++TAAHC Q 
Sbjct: 177 SCGKRVVPL--NVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQK 234

Query: 417 RPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCA 476
              P   TV  G +       P     VR + +HE +   + ++D+A++++      S  
Sbjct: 235 YKNPHQWTVSFGTKIN----PPLMKRNVRRFIIHEKYRSAAREYDIAVVQVS-----SRV 285

Query: 477 LLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPD 536
             S  ++ +CLP  +A         + G+G  + G E     L+EA+V  +S + C  P 
Sbjct: 286 TFSDDIRQICLPEASASFQPNLTVHITGFGALYYGGESQND-LREARVKIISDDVCKQPQ 344

Query: 537 VHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKP 596
           V+G+ I PGM CAG++EG  DAC+GDSGGPLV  D   +    L GI+SWG  CG ++KP
Sbjct: 345 VYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRD--LKDTWYLIGIVSWGDNCGQKDKP 402

Query: 597 GVYTDVAYYLAWIREHT 613
           GVYT V YY  WI   T
Sbjct: 403 GVYTQVTYYRNWIASKT 419


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  161 bits (408), Expect = 1e-39
 Identities = 97/257 (37%), Positives = 136/257 (52%), Gaps = 12/257 (4%)

Query: 357 LSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSF-CAGSLIAPCWVLTAAHCLQ 415
           L C +   + L+S  R+VGG     G  P+ A++  G    C GS++AP WV+TAAHC+ 
Sbjct: 204 LRCSECGARPLAS--RIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMH 261

Query: 416 DRPAPEDLTVVLGQERRNHSC-EPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGS 474
                   +  +     +HS   P Q   V     H  +S  ++ +D+ALLRLQ   +  
Sbjct: 262 SFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALN-- 319

Query: 475 CALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSA 534
               S  V  VCLP+      + + C V+GWGH        +  LQ+  VP  S + C++
Sbjct: 320 ---FSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNS 376

Query: 535 PDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRN 594
             V+  ++ P MLCAG+L+G  DACQGDSGGPLVC D    R   L G++SWG GC + N
Sbjct: 377 SCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWR---LVGVVSWGRGCAEPN 433

Query: 595 KPGVYTDVAYYLAWIRE 611
            PGVY  VA +L WI +
Sbjct: 434 HPGVYAKVAEFLDWIHD 450


>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
          Length = 416

 Score =  160 bits (405), Expect = 3e-39
 Identities = 91/256 (35%), Positives = 133/256 (51%), Gaps = 13/256 (5%)

Query: 359 CGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYW-GHSFCAGSLIAPCWVLTAAHCLQDR 417
           CG+++  S+ +  ++V G  +L GA P+ A++ W G  +C  SLI+  W+L+AAHC   +
Sbjct: 171 CGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKK 230

Query: 418 PAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCAL 477
              +D TV  G        +P  T  V++   HE +S      D+AL++L E+       
Sbjct: 231 NNSKDWTVNFGIVVN----KPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEVS----- 281

Query: 478 LSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDV 537
            + Y++ +CLP    + SE     V GWG  +     +   LQE  +  +  + C+A   
Sbjct: 282 FTEYIRKICLPEAKMKLSENDNVVVTGWGTLYMNGS-FPVILQEDFLKIIDNKICNASYA 340

Query: 538 HGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPG 597
           +   +   MLCAGF+ G  DACQ DSGGPL   D  +     L GI+SWG GCG +NKPG
Sbjct: 341 YSGFVTDTMLCAGFMSGEADACQNDSGGPLAYPD--SRNIWHLVGIVSWGDGCGKKNKPG 398

Query: 598 VYTDVAYYLAWIREHT 613
           VYT V  Y  WI   T
Sbjct: 399 VYTRVTSYRNWITSKT 414


>gi|148613878 acrosin precursor [Homo sapiens]
          Length = 421

 Score =  156 bits (395), Expect = 5e-38
 Identities = 97/270 (35%), Positives = 138/270 (51%), Gaps = 20/270 (7%)

Query: 352 TRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAAL----YWGHSF--CAGSLIAPC 405
           T +GP  CG R R++     R+VGG  A  GA P++ +L    Y  H +  C GSL+   
Sbjct: 24  TCDGP--CGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSR 81

Query: 406 WVLTAAHCLQDRPAPEDLTVVLGQERRNHSCE-----PCQTLAVRSYRLHEAFSPVSYQH 460
           WVLTAAHC   +    D  +V G +   +        P Q   V    +HE ++  +  +
Sbjct: 82  WVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGN 141

Query: 461 DLALLRLQEDADGSCALLSPYVQPVCLPS-GAARPSETTLCQVAGWGHQFEGAEEYASFL 519
           D+AL+ +      SC     ++ P CLP   A  P  +  C VAGWG+  E A   +S L
Sbjct: 142 DIALVEITPPI--SCGR---FIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSIL 196

Query: 520 QEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLT 579
            EA+V  + L+ C++   +   + P  +CAG+  G  D CQGDSGGPL+C+D + E    
Sbjct: 197 MEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKD-SKESAYV 255

Query: 580 LQGIISWGSGCGDRNKPGVYTDVAYYLAWI 609
           + GI SWG GC    +PG+YT    YL WI
Sbjct: 256 VVGITSWGVGCARAKRPGIYTATWPYLNWI 285



 Score = 36.2 bits (82), Expect = 0.091
 Identities = 25/86 (29%), Positives = 32/86 (37%), Gaps = 11/86 (12%)

Query: 303 PPTPVSPRLHV--PLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCG 360
           PP P+ PR     P  P  P PP P P +  PP    P         PP+ +    L  G
Sbjct: 331 PPRPLPPRPPAAQPRPPPSPPPPPPPPASPLPPPPPPP---------PPTPSSTTKLPQG 381

Query: 361 QRLRKSLSSMTRVVGGLVALRGAHPY 386
               K L  +  V+ G     G + Y
Sbjct: 382 LSFAKRLQQLIEVLKGKTYSDGKNHY 407


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  156 bits (395), Expect = 5e-38
 Identities = 107/310 (34%), Positives = 146/310 (47%), Gaps = 21/310 (6%)

Query: 306 PVSPRLH-VPLMPAQPAPPKPQ-PTTRTPPQS-QTPGALPAKREQPPSLTRNGPLSCGQR 362
           P++P +   P  P+   P  P+ P   TP +S Q    +P      P L       CG R
Sbjct: 441 PLAPTMAPAPAAPSTAWPTSPESPVVSTPTKSMQALSTVPLDWVTVPKLQE-----CGAR 495

Query: 363 LRKSLSSMTRVVGGLVALRGAHPYIAALYWG-HSFCAGSLIAPCWVLTAAHCLQDRPAPE 421
              ++   TRVVGG  A  G  P+  +L  G   FC  +++   W+L+AAHC       E
Sbjct: 496 --PAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKV-E 552

Query: 422 DLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPY 481
            +   LG             + +R   LH  ++P     DLA+L L      S    + Y
Sbjct: 553 QVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLEL-----ASPLAFNKY 607

Query: 482 VQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSS 541
           +QPVCLP    +      C ++GWG+  EG       LQ+A V  +  + CS   ++  S
Sbjct: 608 IQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSV--LYNFS 665

Query: 542 ILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTD 601
           +   M+CAGFLEG  D+CQGDSGGPL CE+  A     L GI+SWG GC    KPGVYT 
Sbjct: 666 LTDRMICAGFLEGKVDSCQGDSGGPLACEE--APGVFYLAGIVSWGIGCAQVKKPGVYTR 723

Query: 602 VAYYLAWIRE 611
           +     WI E
Sbjct: 724 ITRLKGWILE 733



 Score =  149 bits (376), Expect = 7e-36
 Identities = 113/334 (33%), Positives = 155/334 (46%), Gaps = 35/334 (10%)

Query: 298  PTQAAPPTPV------SPR----LHVP-LMPAQPAPPKPQPTTRTPPQSQTPGALPAKRE 346
            P   +PP+        SPR    L VP   P++P P      T  P  S         R 
Sbjct: 739  PLPMSPPSTTRMLATTSPRTTAGLTVPGATPSRPTPGAASRVTGQPANSTLSAVSTTARG 798

Query: 347  QPP------SLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSF--CA 398
            Q P      + T      CG     + +++TR+VGG  A RG  P+  +L+       C 
Sbjct: 799  QTPFPDAPEATTHTQLPDCGL----APAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCG 854

Query: 399  GSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSY 458
              L+A  W+L+AAHC      P+     LG    + +    + +A R Y+ H  ++  + 
Sbjct: 855  AVLVAERWLLSAAHCFDVYGDPKQWAAFLGTPFLSGAEGQLERVA-RIYK-HPFYNLYTL 912

Query: 459  QHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASF 518
             +D+ALL L           S  V+P+CLP  A RP + T C + GWG   EG    A  
Sbjct: 913  DYDVALLEL-----AGPVRRSRLVRPICLPEPAPRPPDGTRCVITGWGSVREGGS-MARQ 966

Query: 519  LQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRL 578
            LQ+A V  LS + C     +   I   MLCAGF +GG D+C GD+GGPL C + +   R 
Sbjct: 967  LQKAAVRLLSEQTCRR--FYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSG--RW 1022

Query: 579  TLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREH 612
             L G+ SWG GCG  + PGVYT VA    WI +H
Sbjct: 1023 VLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQH 1056



 Score =  137 bits (344), Expect = 4e-32
 Identities = 82/243 (33%), Positives = 121/243 (49%), Gaps = 10/243 (4%)

Query: 372 RVVGGLVALRGAHPYIAALYWGHS-FCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQE 430
           R+VGG+ A  G  P+ A+L      FC  ++I   W+++AAHC  +   P      +G  
Sbjct: 202 RIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDPTKWVAYVGAT 261

Query: 431 RRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSG 490
             + S        V     H  ++  +   D+A+L L             ++QPVCLP+ 
Sbjct: 262 YLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLP-----FGRHIQPVCLPAA 316

Query: 491 AARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAG 550
                 +  C ++GWG+  E        LQ+A V  L    C++  ++G S+   M+CAG
Sbjct: 317 THIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS--LYGHSLTDRMVCAG 374

Query: 551 FLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIR 610
           +L+G  D+CQGDSGGPLVCE+ +   R  L GI+SWG GC +  +PGVY  V     WI 
Sbjct: 375 YLDGKVDSCQGDSGGPLVCEEPSG--RFFLAGIVSWGIGCAEARRPGVYARVTRLRDWIL 432

Query: 611 EHT 613
           E T
Sbjct: 433 EAT 435


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  155 bits (393), Expect = 8e-38
 Identities = 94/268 (35%), Positives = 132/268 (49%), Gaps = 16/268 (5%)

Query: 351 LTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPY-IAALYWGHSFCAGSLIAPCWVLT 409
           L R+G  + G      ++   R+ GG  A+ G  P+ ++  Y G   C GSL++  WVL+
Sbjct: 23  LLRSGTGAEGAEAPCGVAPQARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLS 82

Query: 410 AAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQE 469
           AAHC       E   V LG  + +   E  +   ++    H ++     Q D+ALL+L  
Sbjct: 83  AAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSR 142

Query: 470 DADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASF-LQEAQVPFLS 528
                    S Y++P+CLP+  A       C V GWGH            LQ+ +VP +S
Sbjct: 143 PIT-----FSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLIS 197

Query: 529 LERCS------APDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQG 582
            E C+      A       +   M+CAG++EGG DACQGDSGGPL C     E    L G
Sbjct: 198 RETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSC---PVEGLWYLTG 254

Query: 583 IISWGSGCGDRNKPGVYTDVAYYLAWIR 610
           I+SWG  CG RN+PGVYT  + Y +WI+
Sbjct: 255 IVSWGDACGARNRPGVYTLASSYASWIQ 282


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  155 bits (392), Expect = 1e-37
 Identities = 89/246 (36%), Positives = 130/246 (52%), Gaps = 14/246 (5%)

Query: 372 RVVGGLVALRGAHPYIAALYWG----HSFCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVL 427
           R+VGG  ++RG  P+   L+         C GS+I   W+LTAAHC     +P+ L V  
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYS 446

Query: 428 GQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCL 487
           G   ++   E      V+   +H+ +      +D+ALL+L+   +      +   +P+CL
Sbjct: 447 GILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVN-----YTDSQRPICL 501

Query: 488 PSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGML 547
           PS   R    T C V GWG++ +  ++  + LQ+A++P ++ E C      G  I   M+
Sbjct: 502 PSKGDRNVIYTDCWVTGWGYR-KLRDKIQNTLQKAKIPLVTNEECQKR-YRGHKITHKMI 559

Query: 548 CAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLA 607
           CAG+ EGG DAC+GDSGGPL C+         L GI SWG GC  R +PGVYT+V  Y+ 
Sbjct: 560 CAGYREGGKDACKGDSGGPLSCKHNEVWH---LVGITSWGEGCAQRERPGVYTNVVEYVD 616

Query: 608 WIREHT 613
           WI E T
Sbjct: 617 WILEKT 622


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  154 bits (390), Expect = 2e-37
 Identities = 93/247 (37%), Positives = 132/247 (53%), Gaps = 15/247 (6%)

Query: 367 LSSMT-RVVGGLVALRGAHPYIAALYWGHS-FCAGSLIAPCWVLTAAHC--LQDRPAPED 422
           L +MT R+VGG +A     P+  +L++G +  C G+LI   WVLTAAHC  +      E 
Sbjct: 319 LRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG 378

Query: 423 LTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYV 482
             V  G    +   E     ++    ++  ++     +D+AL+RL +        LS ++
Sbjct: 379 WKVYAGTSNLHQLPEAA---SIAEIIINSNYTDEEDDYDIALMRLSKPLT-----LSAHI 430

Query: 483 QPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSI 542
            P CLP      S    C + G+G   E  ++ + FL+E QV  +  ++C+   V+ S +
Sbjct: 431 HPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYL 490

Query: 543 LPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDV 602
            P M+CAG L GG D+CQGDSGGPLVCE      R  L G+ SWG+GCG RNKPGVYT V
Sbjct: 491 TPRMMCAGDLRGGRDSCQGDSGGPLVCEQ---NNRWYLAGVTSWGTGCGQRNKPGVYTKV 547

Query: 603 AYYLAWI 609
              L WI
Sbjct: 548 TEVLPWI 554


>gi|148231605 ovochymase 2 [Homo sapiens]
          Length = 564

 Score =  154 bits (388), Expect = 3e-37
 Identities = 96/276 (34%), Positives = 141/276 (51%), Gaps = 31/276 (11%)

Query: 358 SCGQRLRKS-----LSSMTRVVGGLVALRGAHPYIAALYWGHS-FCAGSLIAPCWVLTAA 411
           SCGQ L K       +  +R++GG    +G++P+  +L       C GS+++P WV+TAA
Sbjct: 32  SCGQSLVKVQPWNYFNIFSRILGGSQVEKGSYPWQVSLKQRQKHICGGSIVSPQWVITAA 91

Query: 412 HCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFS---PVSYQHDLALLRLQ 468
           HC+ +R     L V  G+   + +    QTL + +  +H  FS   P+ Y  D+ALL++ 
Sbjct: 92  HCIANRNIVSTLNVTAGEYDLSQTDPGEQTLTIETVIIHPHFSTKKPMDY--DIALLKM- 148

Query: 469 EDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLS 528
                       +V P+CLP    +     +C  AGWG   EG    +  LQE  +P L+
Sbjct: 149 ----AGAFQFGHFVGPICLPELREQFEAGFICTTAGWGRLTEGG-VLSQVLQEVNLPILT 203

Query: 529 LERCSAPDVHGSSILPG--MLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISW 586
            E C A  +     + G   LC GF +GG DACQGDSGG L+C ++  +   TL G+ SW
Sbjct: 204 WEECVAALLTLKRPISGKTFLCTGFPDGGRDACQGDSGGSLMCRNK--KGAWTLAGVTSW 261

Query: 587 GSGCG----------DRNKPGVYTDVAYYLAWIREH 612
           G GCG          D+  PG++TD++  L WI EH
Sbjct: 262 GLGCGRGWRNNVRKSDQGSPGIFTDISKVLPWIHEH 297


>gi|32698940 transmembrane protease, serine 12 [Homo sapiens]
          Length = 348

 Score =  152 bits (384), Expect = 9e-37
 Identities = 93/296 (31%), Positives = 143/296 (48%), Gaps = 18/296 (6%)

Query: 323 PKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRG 382
           P P+P   +         L  +RE            CG    K +   +R++GG  A  G
Sbjct: 33  PSPEPAASSQQAEAVRKRLRRRREGGAHAK-----DCGTAPLKDVLQGSRIIGGTEAQAG 87

Query: 383 AHPYIAALYWGHS-----FCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCE 437
           A P++ +L   +       C G+L+   WVLTAAHC +D   P   T V+G    +    
Sbjct: 88  AWPWVVSLQIKYGRVLVHVCGGTLVRERWVLTAAHCTKDASDPLMWTAVIGTNNIHGRYP 147

Query: 438 PCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSE- 496
             + + +++  +H  F   SY +D+AL  L++         + Y+QP+CLP    +  + 
Sbjct: 148 HTKKIKIKAIIIHPNFILESYVNDIALFHLKK-----AVRYNDYIQPICLPFDVFQILDG 202

Query: 497 TTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGT 556
            T C ++GWG   E      + LQ+A+V ++S E C++   +G  I     CAG  +G  
Sbjct: 203 NTKCFISGWGRTKEEGNA-TNILQDAEVHYISREMCNSERSYGGIIPNTSFCAGDEDGAF 261

Query: 557 DACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREH 612
           D C+GDSGGPL+C      +R  + GI S+G GCG R  PGVY   ++Y  W+ EH
Sbjct: 262 DTCRGDSGGPLMCY-LPEYKRFFVMGITSYGHGCGRRGFPGVYIGPSFYQKWLTEH 316


>gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]
          Length = 247

 Score =  152 bits (383), Expect = 1e-36
 Identities = 88/243 (36%), Positives = 125/243 (51%), Gaps = 29/243 (11%)

Query: 372 RVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHC----LQDRPAPEDLTVVL 427
           ++VGG      + PY  +L  G+ FC GSLI   WV++A HC    +Q R    ++ V+ 
Sbjct: 23  KIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLE 82

Query: 428 GQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCL 487
           G E         Q +       H  +   +  +D+ L++L      S A+++  V  + L
Sbjct: 83  GNE---------QFINAAKIIRHPQYDRKTLNNDIMLIKLS-----SRAVINARVSTISL 128

Query: 488 PSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGML 547
           P+  A P+  T C ++GWG+      +Y   LQ    P LS  +C A   +   I   M 
Sbjct: 129 PT--APPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEAS--YPGKITSNMF 184

Query: 548 CAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLA 607
           C GFLEGG D+CQGDSGGP+VC  Q       LQG++SWG GC  +NKPGVYT V  Y+ 
Sbjct: 185 CVGFLEGGKDSCQGDSGGPVVCNGQ-------LQGVVSWGDGCAQKNKPGVYTKVYNYVK 237

Query: 608 WIR 610
           WI+
Sbjct: 238 WIK 240


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  151 bits (381), Expect = 2e-36
 Identities = 97/264 (36%), Positives = 138/264 (52%), Gaps = 23/264 (8%)

Query: 359 CGQRLRKSLSSMTRVVGGLVALRGAHPY---IAALYWGHSFCAGSLIAPCWVLTAAHC-L 414
           CG R   S +   RVVGG  A  G  P+   + AL  GH  C  SLI+P W+++AAHC +
Sbjct: 604 CGLR---SFTRQARVVGGTDADEGEWPWQVSLHALGQGH-ICGASLISPNWLVSAAHCYI 659

Query: 415 QDR----PAPEDLTVVLG-QERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQE 469
            DR      P   T  LG  ++   S    Q   ++    H  F+  ++ +D+ALL L++
Sbjct: 660 DDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEK 719

Query: 470 DADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSL 529
            A+      S  V+P+CLP  +          V GWGH   G    A  LQ+ ++  ++ 
Sbjct: 720 PAE-----YSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTG-ALILQKGEIRVINQ 773

Query: 530 ERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSG 589
             C   ++    I P M+C GFL GG D+CQGDSGGPL   +  A+ R+   G++SWG G
Sbjct: 774 TTCE--NLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVE--ADGRIFQAGVVSWGDG 829

Query: 590 CGDRNKPGVYTDVAYYLAWIREHT 613
           C  RNKPGVYT +  +  WI+E+T
Sbjct: 830 CAQRNKPGVYTRLPLFRDWIKENT 853


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  150 bits (379), Expect = 3e-36
 Identities = 91/249 (36%), Positives = 124/249 (49%), Gaps = 14/249 (5%)

Query: 371 TRVVGGLVALRGAHPYIAALYWG----HSFCAGSLIAPCWVLTAAHCLQDRPAPEDLTVV 426
           TR+VGG  +  G  P+  +L          C GSLI   WVLTAAHC    P  +   + 
Sbjct: 389 TRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIY 448

Query: 427 LGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVC 486
            G    +   +      ++   +H+ +      HD+AL++LQ   +      + + +P+C
Sbjct: 449 SGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLN-----YTEFQKPIC 503

Query: 487 LPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGM 546
           LPS     +  T C V GWG   E  E   + LQ+  +P ++ E C         I   M
Sbjct: 504 LPSKGDTSTIYTNCWVTGWGFSKEKGE-IQNILQKVNIPLVTNEECQKR-YQDYKITQRM 561

Query: 547 LCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYL 606
           +CAG+ EGG DAC+GDSGGPLVC+     R   L GI SWG GC  R +PGVYT VA Y+
Sbjct: 562 VCAGYKEGGKDACKGDSGGPLVCKHNGMWR---LVGITSWGEGCARREQPGVYTKVAEYM 618

Query: 607 AWIREHTVS 615
            WI E T S
Sbjct: 619 DWILEKTQS 627


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  150 bits (378), Expect = 4e-36
 Identities = 94/244 (38%), Positives = 132/244 (54%), Gaps = 13/244 (5%)

Query: 371 TRVVGGLVALRGAHPYIAALYW-GHSFCAGSLIAPCWVLTAAHCLQDRPAPEDL--TVVL 427
           +R+VGG V+  G  P+ A+L   G   C G+LIA  WV+TAAHC Q+      +  TV L
Sbjct: 575 SRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFL 634

Query: 428 GQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCL 487
           G+  +N       +  V    LH      S+ +D+ALL+L      S A     V+PVCL
Sbjct: 635 GKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAA-----VRPVCL 689

Query: 488 PSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGML 547
           P+ +        C + GWG   EG    ++ LQ+  V  +  + CS  +V+   + P ML
Sbjct: 690 PARSHFFEPGLHCWITGWGALREGGP-ISNALQKVDVQLIPQDLCS--EVYRYQVTPRML 746

Query: 548 CAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLA 607
           CAG+ +G  DACQGDSGGPLVC  +A   R  L G++SWG GCG  N  GVYT +   ++
Sbjct: 747 CAGYRKGKKDACQGDSGGPLVC--KALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVIS 804

Query: 608 WIRE 611
           WI++
Sbjct: 805 WIQQ 808


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.463 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,338,768
Number of Sequences: 37866
Number of extensions: 1735415
Number of successful extensions: 18049
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 434
Number of HSP's successfully gapped in prelim test: 557
Number of HSP's that attempted gapping in prelim test: 10153
Number of HSP's gapped (non-prelim): 5480
length of query: 615
length of database: 18,247,518
effective HSP length: 108
effective length of query: 507
effective length of database: 14,157,990
effective search space: 7178100930
effective search space used: 7178100930
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.