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Search of human proteins with 145275174
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens]
(708 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens] 1447 0.0
gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens] 1233 0.0
gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens] 1105 0.0
gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens] 442 e-124
gi|166295173 kin of IRRE like [Homo sapiens] 435 e-122
gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens] 427 e-119
gi|4758822 nephrin precursor [Homo sapiens] 125 1e-28
gi|118572606 hemicentin 1 [Homo sapiens] 125 1e-28
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 114 3e-25
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 114 3e-25
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 112 2e-24
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 107 3e-23
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 107 5e-23
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ... 100 4e-21
gi|21686977 cell adhesion molecule 4 [Homo sapiens] 100 4e-21
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 99 2e-20
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 94 4e-19
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [... 94 4e-19
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [... 94 4e-19
gi|224994173 roundabout 1 isoform d [Homo sapiens] 92 2e-18
gi|224994171 roundabout 1 isoform c [Homo sapiens] 92 2e-18
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 92 2e-18
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 92 2e-18
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 91 5e-18
gi|109150416 peroxidasin [Homo sapiens] 90 6e-18
gi|13489095 sialoadhesin precursor [Homo sapiens] 90 6e-18
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 89 1e-17
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 86 9e-17
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [... 86 1e-16
gi|11225258 myelin associated glycoprotein isoform a precursor [... 85 2e-16
>gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens]
Length = 708
Score = 1447 bits (3745), Expect = 0.0
Identities = 708/708 (100%), Positives = 708/708 (100%)
Query: 1 MLRMRVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSG 60
MLRMRVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSG
Sbjct: 1 MLRMRVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSG 60
Query: 61 LALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVL 120
LALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVL
Sbjct: 61 LALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVL 120
Query: 121 VPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG 180
VPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG
Sbjct: 121 VPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG 180
Query: 181 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE 240
TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE
Sbjct: 181 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE 240
Query: 241 GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSA 300
GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSA
Sbjct: 241 GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSA 300
Query: 301 NRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATL 360
NRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATL
Sbjct: 301 NRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATL 360
Query: 361 RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCL 420
RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCL
Sbjct: 361 RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCL 420
Query: 421 VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS 480
VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS
Sbjct: 421 VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS 480
Query: 481 RSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKAS 540
RSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKAS
Sbjct: 481 RSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKAS 540
Query: 541 ASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPT 600
ASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPT
Sbjct: 541 ASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPT 600
Query: 601 NGYYKVRGVSVSLSLGEAPGGGLFLPPPSPLGPPGTPTFYDFNPHLGMVPPCRLYRARAG 660
NGYYKVRGVSVSLSLGEAPGGGLFLPPPSPLGPPGTPTFYDFNPHLGMVPPCRLYRARAG
Sbjct: 601 NGYYKVRGVSVSLSLGEAPGGGLFLPPPSPLGPPGTPTFYDFNPHLGMVPPCRLYRARAG 660
Query: 661 YLTTPHPRAFTSYIKPTSFGPPDLAPGTPPFPYAAFPTPSHPRLQTHV 708
YLTTPHPRAFTSYIKPTSFGPPDLAPGTPPFPYAAFPTPSHPRLQTHV
Sbjct: 661 YLTTPHPRAFTSYIKPTSFGPPDLAPGTPPFPYAAFPTPSHPRLQTHV 708
>gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens]
Length = 633
Score = 1233 bits (3190), Expect = 0.0
Identities = 610/610 (100%), Positives = 610/610 (100%)
Query: 1 MLRMRVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSG 60
MLRMRVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSG
Sbjct: 1 MLRMRVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSG 60
Query: 61 LALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVL 120
LALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVL
Sbjct: 61 LALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVL 120
Query: 121 VPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG 180
VPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG
Sbjct: 121 VPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG 180
Query: 181 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE 240
TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE
Sbjct: 181 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE 240
Query: 241 GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSA 300
GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSA
Sbjct: 241 GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSA 300
Query: 301 NRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATL 360
NRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATL
Sbjct: 301 NRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATL 360
Query: 361 RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCL 420
RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCL
Sbjct: 361 RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCL 420
Query: 421 VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS 480
VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS
Sbjct: 421 VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS 480
Query: 481 RSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKAS 540
RSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKAS
Sbjct: 481 RSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKAS 540
Query: 541 ASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPT 600
ASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPT
Sbjct: 541 ASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPT 600
Query: 601 NGYYKVRGVS 610
NGYYKVRGVS
Sbjct: 601 NGYYKVRGVS 610
>gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens]
Length = 583
Score = 1105 bits (2857), Expect = 0.0
Identities = 560/610 (91%), Positives = 560/610 (91%), Gaps = 50/610 (8%)
Query: 1 MLRMRVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSG 60
MLRMRVPALLVLLFCFRGRA
Sbjct: 1 MLRMRVPALLVLLFCFRGRA---------------------------------------- 20
Query: 61 LALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVL 120
GWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVL
Sbjct: 21 ----------GWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVL 70
Query: 121 VPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG 180
VPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG
Sbjct: 71 VPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG 130
Query: 181 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE 240
TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE
Sbjct: 131 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE 190
Query: 241 GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSA 300
GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSA
Sbjct: 191 GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSA 250
Query: 301 NRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATL 360
NRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATL
Sbjct: 251 NRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATL 310
Query: 361 RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCL 420
RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCL
Sbjct: 311 RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCL 370
Query: 421 VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS 480
VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS
Sbjct: 371 VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS 430
Query: 481 RSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKAS 540
RSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKAS
Sbjct: 431 RSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKAS 490
Query: 541 ASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPT 600
ASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPT
Sbjct: 491 ASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPT 550
Query: 601 NGYYKVRGVS 610
NGYYKVRGVS
Sbjct: 551 NGYYKVRGVS 560
>gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens]
Length = 778
Score = 442 bits (1137), Expect = e-124
Identities = 252/601 (41%), Positives = 342/601 (56%), Gaps = 30/601 (4%)
Query: 26 FLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQ 85
F QQP+D VV+ G+ L CA+ Y G V W K GLALG RDL + +Y + GN +G+
Sbjct: 50 FSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGE 109
Query: 86 HDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLT 145
H L I EL+D+A YECQA QA +RSRPA+L VLVPP+ P +LGGP +SL AG P NLT
Sbjct: 110 HHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLT 169
Query: 146 CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCR 205
C + +A+P ++W R G +++GAT+ +TLL++G S+ STL ++P ++G + VCR
Sbjct: 170 CHA-DNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCR 228
Query: 206 ARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGG 265
A ++A+P G++T++T+ +Q+PP V LS P V E V F C A A P VT YRWAK G
Sbjct: 229 ATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRG 288
Query: 266 SPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDV 325
+ A G D ++ +EPVSCEV+NA+GS N S +DV FGP + +P+ + VD+
Sbjct: 289 QIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDL 348
Query: 326 GEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLR 385
G DA FSCAW GNP + W +RG VL + TL L SV EDAG YVCRA G
Sbjct: 349 GSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVG-- 406
Query: 386 GGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQG 445
G E LTVN PP++++ + A +++C + ++P PD + WSW E LE+G+ G
Sbjct: 407 AGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSG 466
Query: 446 RFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARN---------RLGEGGA 496
R+ VET E G+IS L IS +DF +NC+A N RL E G+
Sbjct: 467 RYTVETISTEE-------GVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGS 519
Query: 497 Q----ASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKASASFSEQKNLMRI 552
+ A L + V I V A L+++ T VA CC R + KN +R+
Sbjct: 520 EMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRV 579
Query: 553 P-GSSDGSSSRGPEEEETGSR--EDRGPI----VHTDHSDLVLEEKGTLETKDPTNGYYK 605
+ +S R EE T + DRG V L EEK KDPTNGYY
Sbjct: 580 EIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYS 639
Query: 606 V 606
V
Sbjct: 640 V 640
Score = 39.7 bits (91), Expect = 0.010
Identities = 50/200 (25%), Positives = 74/200 (37%), Gaps = 27/200 (13%)
Query: 24 PHFLQQPEDLVVLLGEEARLPCALGAYWGL-VQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P +P+ L+V LG +A CA L + W K G SG
Sbjct: 335 PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG-----------------SGVVL 377
Query: 83 NGQHDLHIRPVELEDEASYECQAT--QAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGV 140
+ + L ++ V ED Y C+A + G R L V P P + + + G
Sbjct: 378 SNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGP---PIISSTQTQHALHGE 434
Query: 141 PANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGA 200
+ C R P +++ VL G + T+ T V STLT++ D
Sbjct: 435 KGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQ 494
Query: 201 T-FVCRARSQALPTGRDTAI 219
T + C A + G DT I
Sbjct: 495 TIYNCTAWNS---FGSDTEI 511
>gi|166295173 kin of IRRE like [Homo sapiens]
Length = 757
Score = 435 bits (1118), Expect = e-122
Identities = 239/602 (39%), Positives = 332/602 (55%), Gaps = 25/602 (4%)
Query: 21 GPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGN 80
G F Q+P D V+ G+ A LPC L Y G+VQWTK GLALG + L W RY + G+
Sbjct: 18 GTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGS 77
Query: 81 AANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGV 140
A GQ++L I EL D+ASYECQAT+A LRSR A+L VL+PPE ++ GGP + L AG
Sbjct: 78 ADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGT 137
Query: 141 PANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGA 200
P NLTCR+ +A+P ++WFRDG +GA LLK+G + S L + P D G
Sbjct: 138 PHNLTCRAF-NAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGR 196
Query: 201 TFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYR 260
F CR+ ++A+P+G++T+I L + +PP VTLS P TVQEGE+V+F CQATA P + GYR
Sbjct: 197 VFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYR 256
Query: 261 WAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEP 320
WAKGG + A R E D SF TEPVSCEV N VGS N ST ++V F P + P+P
Sbjct: 257 WAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKP 316
Query: 321 VSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVGPEDAGDYVCRAEAG 380
+ D+G D + +C W GNP +TWT++ VL + L L SV DAG Y CRA
Sbjct: 317 TTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVP 376
Query: 381 LSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLE 440
G+ E L VN PP++++ A +++C + ++P PD + W+W E FLE
Sbjct: 377 RIGV--AEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLE 434
Query: 441 AGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASL 500
G+ R+ VE R G G++S L I+ E+DF +NC+A N G G A L
Sbjct: 435 VGTLERYTVE-------RTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQL 487
Query: 501 GRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKASASFSEQKNL-MRIPG-SSDG 558
R++LP I A+ L+ + +R K S + L +++ + +
Sbjct: 488 EEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREP 547
Query: 559 SSSRGPEEEETGSREDRGPIVHTDHSDL-------------VLEEKGTLETKDPTNGYYK 605
+ E++T S ++ +S ++ + E KDPTNGYY
Sbjct: 548 LTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYN 607
Query: 606 VR 607
VR
Sbjct: 608 VR 609
>gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens]
Length = 600
Score = 427 bits (1097), Expect = e-119
Identities = 232/548 (42%), Positives = 322/548 (58%), Gaps = 30/548 (5%)
Query: 26 FLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQ 85
F QQP+D VV+ G+ L CA+ Y G V W K GLALG RDL + +Y + GN +G+
Sbjct: 50 FSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGE 109
Query: 86 HDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLT 145
H L I EL+D+A YECQA QA +RSRPA+L VLVPP+ P +LGGP +SL AG P NLT
Sbjct: 110 HHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLT 169
Query: 146 CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCR 205
C + +A+P ++W R G +++GAT+ +TLL++G S+ STL ++P ++G + VCR
Sbjct: 170 CHA-DNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCR 228
Query: 206 ARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGG 265
A ++A+P G++T++T+ +Q+PP V LS P V E V F C A A P VT YRWAK G
Sbjct: 229 ATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRG 288
Query: 266 SPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDV 325
+ A G D ++ +EPVSCEV+NA+GS N S +DV FGP + +P+ + VD+
Sbjct: 289 QIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDL 348
Query: 326 GEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLR 385
G DA FSCAW GNP + W +RG VL + TL L SV EDAG YVCRA G
Sbjct: 349 GSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVG-- 406
Query: 386 GGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQG 445
G E LTVN PP++++ + A +++C + ++P PD + WSW E LE+G+ G
Sbjct: 407 AGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSG 466
Query: 446 RFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARN---------RLGEGGA 496
R+ VET E G+IS L IS +DF +NC+A N RL E G+
Sbjct: 467 RYTVETISTEE-------GVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGS 519
Query: 497 Q----ASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKASASFS-------E 545
+ A L + V I V A L+++ T VA CC R +++ S E
Sbjct: 520 EMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRSTGGRSGISGRGTE 579
Query: 546 QKNLMRIP 553
+K +R+P
Sbjct: 580 KKARLRLP 587
Score = 39.7 bits (91), Expect = 0.010
Identities = 50/200 (25%), Positives = 74/200 (37%), Gaps = 27/200 (13%)
Query: 24 PHFLQQPEDLVVLLGEEARLPCALGAYWGL-VQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P +P+ L+V LG +A CA L + W K G SG
Sbjct: 335 PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG-----------------SGVVL 377
Query: 83 NGQHDLHIRPVELEDEASYECQAT--QAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGV 140
+ + L ++ V ED Y C+A + G R L V P P + + + G
Sbjct: 378 SNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGP---PIISSTQTQHALHGE 434
Query: 141 PANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGA 200
+ C R P +++ VL G + T+ T V STLT++ D
Sbjct: 435 KGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQ 494
Query: 201 T-FVCRARSQALPTGRDTAI 219
T + C A + G DT I
Sbjct: 495 TIYNCTAWNS---FGSDTEI 511
>gi|4758822 nephrin precursor [Homo sapiens]
Length = 1241
Score = 125 bits (315), Expect = 1e-28
Identities = 107/346 (30%), Positives = 152/346 (43%), Gaps = 37/346 (10%)
Query: 26 FLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQ 85
F PE+L V+ G L C + VQW K GL LG +PG+ RY + G+ A G+
Sbjct: 34 FWALPENLTVVEGASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGE 93
Query: 86 HDLHIRPVELEDEASYECQATQA----GLRSRPAQLHVLVPPE----APQVLGGPSVSLV 137
LHI +L D+A YECQ ++ L S L +LVPP+ P+ G V+ V
Sbjct: 94 FHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPE--AGTMVTWV 151
Query: 138 AGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFH--QTLLKEGTPG---SVESTLTLT 192
AG + C S GDA+P P++ +LL G T + EG+ +VE+T +T
Sbjct: 152 AGQEYVVNCVS-GDAKPAPDIT-----ILLSGQTISDISANVNEGSQQKLFTVEATARVT 205
Query: 193 PFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT----VQEGEKVIFLC 248
P S D+ VC A S AL + T+++ +PP + P V+ G+ + C
Sbjct: 206 PRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPC 265
Query: 249 QATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPV---------SCEVSNAV-- 297
A P+ +W K G PV A G S L V SCE N+V
Sbjct: 266 VARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSA 325
Query: 298 GSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRV 343
G+ L V F P S ++ + SC + + PRV
Sbjct: 326 GTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSS-RPRV 370
Score = 82.0 bits (201), Expect = 2e-15
Identities = 110/430 (25%), Positives = 172/430 (40%), Gaps = 56/430 (13%)
Query: 96 EDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPT 155
+++A + C+A Q S QL V PP +L S +L G NLTC S + P
Sbjct: 521 DNQAKFTCKAGQL---SASTQLAVQFPPTNVTILANAS-ALRPGDALNLTCVSVS-SNPP 575
Query: 156 PELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGR 215
L W ++G L+G + S L L S D G CRA S L
Sbjct: 576 VNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVL-LQVSSRDHGQRVTCRAHSAELRETV 634
Query: 216 DTAITLSLQYPPE------VTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL 269
+ L++ Y PE + ++A V++GE ++ + +A P + W G +
Sbjct: 635 SSFYRLNVLYRPEFLGEQVLVVTA----VEQGEALLPV-SVSANPAPEAFNWTFRGYRLS 689
Query: 270 GARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFGPILQAKPEPV 321
A GPR +++ + V+ N+ G+A LDV + P ++A +P
Sbjct: 690 PAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPT 749
Query: 322 SVDVGEDASFSCAWRGNP-LPRV-TWTRRG---------GAQVLGSGAT--LRLPSVGPE 368
V+VG C NP LP + W R G + + G T LR+
Sbjct: 750 EVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLA 809
Query: 369 DAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV---TALH--SAPAFLRGPARLQCLVFA 423
AG Y C + G++ RL V P V T L +A A L C
Sbjct: 810 QAGAYQCIVDNGVA--PPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARG 867
Query: 424 SPAPDAVVWSWDEGFLEAGSQG-RFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRS 482
P +V++W + + Q R+ T+ +GG+ L+++ ++S Q+
Sbjct: 868 VP---NIVFTWTKNGVPLDLQDPRYTEHTY----HQGGVHSSLLTIANVSAAQDYAL--- 917
Query: 483 FNCSARNRLG 492
F C+A N LG
Sbjct: 918 FTCTATNALG 927
Score = 60.5 bits (145), Expect = 5e-09
Identities = 98/396 (24%), Positives = 151/396 (38%), Gaps = 66/396 (16%)
Query: 90 IRPVELEDEASYECQATQAGLRS---RPAQLHVLVPPEAPQVLGGPSVS---LVAGVPAN 143
+ P ++ C+A+ L + ++VL PP P V+ P + + AG
Sbjct: 204 VTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPP-GPPVIEWPGLDEGHVRAGQSLE 262
Query: 144 LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 203
L C +RG P L W ++G + A E T S L +T D GA
Sbjct: 263 LPCVARG-GNPLATLQWLKNGQPVSTAWG-----TEHTQAVARSVLVMTVRPEDHGAQLS 316
Query: 204 CRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAK 263
C A + ++ ITL + +PP + + E + V C + + P RW
Sbjct: 317 CEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWL 376
Query: 264 GGSPVL--------GARGPRLEVVADASFLTE------PVSCEVSNAV---GSANRSTAL 306
G +L G G + +++ +FL ++CE + + +S L
Sbjct: 377 GWRQLLPMEETVMDGLHGGHIS-MSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLIL 435
Query: 307 DVLFGP---ILQAKPEPVSVDVGEDASFSC-AWRGNPLPRVTW---------------TR 347
+V + ++ PE + G C A GNP P + W +R
Sbjct: 436 NVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESR 495
Query: 348 R---GGAQVLGSGATLRLPSV-GPED-AGDYVCRAEAGLSGLRGGAAEARLTVNAPPV-V 401
R G + GS + L V GP D + C+A LS A +L V PP V
Sbjct: 496 RVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA-GQLS------ASTQLAVQFPPTNV 548
Query: 402 TALHSAPAFLRGPA-RLQCLVFASPAPDAVVWSWDE 436
T L +A A G A L C+ +S P V SWD+
Sbjct: 549 TILANASALRPGDALNLTCVSVSSNPP--VNLSWDK 582
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 125 bits (314), Expect = 1e-28
Identities = 142/516 (27%), Positives = 207/516 (40%), Gaps = 67/516 (12%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P+ P+ LV+LL + L C A G + W K G L G +RY I N
Sbjct: 3713 PNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNH-----ARYSILENGF 3767
Query: 83 NGQHDLHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPE-APQVLGGPSVSLVAGV 140
LHI+ + D Y C AT A G R L V VPP AP G +++++ V
Sbjct: 3768 -----LHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAP---GPTNMTVIVNV 3819
Query: 141 PANLTCRSRGDARPTPELLWFRDGVLL--DGATFHQTLLKEGTPGSVESTLTLTPFSHDD 198
L C + G P P + W ++G LL D LL G S + ++P S DD
Sbjct: 3820 QTTLACEATGI--PKPSINWRKNGHLLNVDQNQNSYRLLSSG------SLVIISP-SVDD 3870
Query: 199 GATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTG 258
AT+ C + A R + L++Q PP + + V + + C A+ P
Sbjct: 3871 TATYECTVTNGAGDDKR--TVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVP-FPS 3927
Query: 259 YRWAKGGSPVLGARGP--------RLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLF 310
W K G +L RG +E++A +C NA GSA+R L V
Sbjct: 3928 IHWTKNGIRLL-PRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHE 3986
Query: 311 GPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG--------GAQVLGSGATLRL 362
P++Q +P + V + C G P P +TW + G VL SG L++
Sbjct: 3987 PPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG-LQI 4045
Query: 363 PSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTA-LHSAPAFLRGPARLQCLV 421
EDAG Y+C A+ G + +L V PPV++ L + P L C
Sbjct: 4046 SRAVREDAGTYMCVAQNPAGTALG---KIKLNVQVPPVISPHLKEYVIAVDKPITLSCEA 4102
Query: 422 FASPAPD--------AVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISG 473
P PD A+V S + L +GS L F P G G +++G
Sbjct: 4103 DGLPPPDITWHKDGRAIVESIRQRVLSSGS----LQIAFVQP---GDAGHYTCMAANVAG 4155
Query: 474 TQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTV 509
+ + + + R R EG + + +LP V
Sbjct: 4156 SSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCV 4191
Score = 103 bits (257), Expect = 5e-22
Identities = 109/426 (25%), Positives = 163/426 (38%), Gaps = 45/426 (10%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P QP +L V+L LPC A G + W K G+ + +A
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSG----------RNHAV 4037
Query: 83 NGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVP 141
L I ED +Y C A AG +L+V VPP V+ V V
Sbjct: 4038 LPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPP----VISPHLKEYVIAVD 4093
Query: 142 ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 201
+T D P P++ W +DG + + Q +L G+ L + D
Sbjct: 4094 KPITLSCEADGLPPPDITWHKDGRAIV-ESIRQRVLSSGS-------LQIAFVQPGDAGH 4145
Query: 202 FVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRW 261
+ C A + A + T +T+ + PP + + +TV E + I C A P W
Sbjct: 4146 YTCMAANVAGSSSTSTKLTVHV--PPRIRSTEGHYTVNENSQAILPCVADGIP-TPAINW 4202
Query: 262 AKGGSPVLGARG-----PRLEVVADASFLTEP--VSCEVSNAVGSANRSTALDVLFGPIL 314
K + G P E++ + L + +C +NA G + +L V P
Sbjct: 4203 KKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTF 4262
Query: 315 QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGA-----QVLGSGATLRLPSVGPED 369
P VS++ GE SC G PLP++TWT + + L + V ED
Sbjct: 4263 TELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKED 4322
Query: 370 AGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAF--LRGPARLQCLVFASPAP 427
+G YVC AE + ++ A + V PPV + + L G A L C V P P
Sbjct: 4323 SGTYVCTAENSVGFVK---AIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTP 4379
Query: 428 DAVVWS 433
+ W+
Sbjct: 4380 -TIQWN 4384
Score = 101 bits (252), Expect = 2e-21
Identities = 109/409 (26%), Positives = 169/409 (41%), Gaps = 81/409 (19%)
Query: 35 VLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQH-------- 86
V+ G++ LPC L L G P R WI +A Q+
Sbjct: 901 VIEGQQLTLPCTL---------------LAGN---PIPERRWIKNSAMLLQNPYITVRSD 942
Query: 87 -DLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANL 144
LHI V+L+D Y C A+ AG ++ + V V P G +S + G+P L
Sbjct: 943 GSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQH--GQQILSTIEGIPVTL 1000
Query: 145 TCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVC 204
C++ G+ P P ++W + G L+ T + + G+ S ++P + G +VC
Sbjct: 1001 PCKASGN--PKPSVIWSKKGELIS------TSSAKFSAGADGSLYVVSPGGEESGE-YVC 1051
Query: 205 RARSQALPTGRDTAIT-------------LSLQYPPEVTLSASPHTVQEGEKVIFLCQAT 251
A + A R +T LS P E+++ A GE+V C+
Sbjct: 1052 TATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLA-------GEEVTLPCEVK 1104
Query: 252 AQPPVTGYRWAKGGSPVLGARGPRLEVVADASF-LTEPVS-------CEVSNAVGSANRS 303
+ PP WAK + ++ PR + S +TE + C +N G+ ++
Sbjct: 1105 SLPPPI-ITWAKE-TQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQA 1162
Query: 304 TALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSG------ 357
L+V P +Q P+ + V VG+ C +G PLP +TW+ +GG+ +L G
Sbjct: 1163 VKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWS-KGGSTMLVDGEHHVSN 1221
Query: 358 --ATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTAL 404
TL + P DAG Y C A ++G E L V PP V L
Sbjct: 1222 PDGTLSIDQATPSDAGIYTCVA-TNIAGT--DETEITLHVQEPPTVEDL 1267
Score = 97.8 bits (242), Expect = 3e-20
Identities = 122/467 (26%), Positives = 187/467 (40%), Gaps = 77/467 (16%)
Query: 24 PHFLQQPEDLVVLLGEEARLPCALGAYWG-LVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P+ + + +++ VL+ + L C A + W K G L + PG S IS N +
Sbjct: 2104 PNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKK---PGLS---ISENRS 2157
Query: 83 NGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPS----VSLV 137
L I +++D Y C+AT AG + +++ VPP +GG ++++
Sbjct: 2158 V----LKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPN----IGGSDELTQLTVI 2209
Query: 138 AGVPANLTCRSRGDARPTPELLWFRDGV-LLDGATFHQTLLKEGTPGSVESTLTLTPFSH 196
G +L C S G P P L+W + G +L + +L G L ++
Sbjct: 2210 EGNLISLLCESSGI--PPPNLIWKKKGSPVLTDSMGRVRILSGGRQ------LQISIAEK 2261
Query: 197 DDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT---VQEGEKVIFLCQATAQ 253
D A + C A + A ++ L + P +T S S T V G+ + C+
Sbjct: 2262 SDAALYSCVASNVAGTAKKE--YNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGI 2319
Query: 254 PPVTGYRWAKGGSPVLGARGPRLEVVADASFL---------TEPVSCEVSNAVGSANRST 304
PP T W K G P++ A+G +E++ + L T C N G ++
Sbjct: 2320 PPPT-VTWMKDGHPLIKAKG--VEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKY 2376
Query: 305 ALDVLFGPIL---QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVL 354
L V P + PE +SV S +C G PLP +TW + G ++L
Sbjct: 2377 DLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRIL 2436
Query: 355 GSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEAR----LTVNAPPVV---TALHSA 407
G LRL EDAG Y C +R A E R L+V PP + L
Sbjct: 2437 SGGRMLRLMQTTMEDAGQYTC-------VVRNAAGEERKIFGLSVLVPPHIVGENTLEDV 2489
Query: 408 PAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAG------SQGRFL 448
+ L C V +P P+ + W D L+ S GRFL
Sbjct: 2490 KVKEKQSVTLTCEVTGNPVPE-ITWHKDGQPLQEDEAHHIISGGRFL 2535
Score = 96.7 bits (239), Expect = 7e-20
Identities = 118/458 (25%), Positives = 176/458 (38%), Gaps = 62/458 (13%)
Query: 22 PSPHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGN 80
PS + P D+ VLLGE L C A G L+QW K G + R +S N
Sbjct: 3245 PSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGET----ERIRVSAN 3300
Query: 81 AANGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPP-------EAPQVLGGP 132
+ L+I D Y C AT AG R L+V V P EA +++
Sbjct: 3301 GST----LNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLV 3356
Query: 133 SVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLT 192
S+ N+ CR+ G P P++ W ++G+ L + H LL G + +
Sbjct: 3357 DTSI------NIECRATG--TPPPQINWLKNGLPLP-LSSHIRLLAAG------QVIRIV 3401
Query: 193 PFSHDDGATFVCRARSQALPTGRDTA-ITLSLQYPPEV--TLSASPHTVQEGEKVIFLCQ 249
D A + C A ++A G D L + PP + ++ TV +G C
Sbjct: 3402 RAQVSDVAVYTCVASNRA---GVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC- 3457
Query: 250 ATAQPPVTGYRWAKGGSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANR 302
T P W + G P+ + G L+++ + + +C SN G ++
Sbjct: 3458 ITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSK 3517
Query: 303 STALDVLFGPILQA--KPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQV 353
L VL P + + E +SV V +C G P P++TW + G Q
Sbjct: 3518 HFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQT 3577
Query: 354 LGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTAL---HSAPAF 410
LG G LR+ + ED G Y C A S E + V+ PP +
Sbjct: 3578 LGGGEVLRISTAQVEDTGRYTCLAS---SPAGDDDKEYLVRVHVPPNIAGTDEPRDITVL 3634
Query: 411 LRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFL 448
L+C A P P + W + L+A + R L
Sbjct: 3635 RNRQVTLECKSDAVP-PPVITWLRNGERLQATPRVRIL 3671
Score = 94.4 bits (233), Expect = 3e-19
Identities = 100/412 (24%), Positives = 159/412 (38%), Gaps = 58/412 (14%)
Query: 31 EDLVVLLGEEARLPCAL-GAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLH 89
E++ VL G + C G + W + G LG L + + L
Sbjct: 3443 EEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMV----------LQ 3492
Query: 90 IRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRS 148
+ E ED Y C A+ +AG S+ L VL PP +S++ P LTC +
Sbjct: 3493 LLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIA 3552
Query: 149 RGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARS 208
G P P++ W +DG L QTL G E L ++ +D + C A S
Sbjct: 3553 SGI--PAPKMTWMKDGRPLPQTDQVQTL------GGGE-VLRISTAQVEDTGRYTCLASS 3603
Query: 209 QALPTGRDTAITLSLQYPPEVTLSASPH--TVQEGEKVIFLCQATAQPPVTGYRWAKGGS 266
A ++ + + + PP + + P TV +V C++ A PP W + G
Sbjct: 3604 PAGDDDKEYLVRVHV--PPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV-ITWLRNGE 3660
Query: 267 PVLGARGPRLEVVADASFL---------TEPVSCEVSNAVGSANRSTALDVLFGPILQAK 317
+ PR+ +++ +L T +C SN G R L V P ++
Sbjct: 3661 RLQAT--PRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGG 3718
Query: 318 PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGAT--------LRLPSVGPED 369
P+ + + + + C G P PR+TW R+ GA + G+ A L + S D
Sbjct: 3719 PQSLVILLNKSTVLECIAEGVPTPRITW-RKDGAVLAGNHARYSILENGFLHIQSAHVTD 3777
Query: 370 AGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLV 421
G Y+C A G R+ + +H P+ GP + +V
Sbjct: 3778 TGRYLCMATNA-----AGTDRRRIDLQ-------VHVPPSIAPGPTNMTVIV 3817
Score = 93.6 bits (231), Expect = 6e-19
Identities = 109/429 (25%), Positives = 167/429 (38%), Gaps = 71/429 (16%)
Query: 96 EDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPS------VSLVAGVPANLTCRS 148
E+ Y C AT AG R QL V V P G S +S++AG L C
Sbjct: 1044 EESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEV 1103
Query: 149 RGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARS 208
+ + P P + W ++ L+ + T L G+ + +T D ++C A +
Sbjct: 1104 K--SLPPPIITWAKETQLISPFSPRHTFLPSGS-------MKITETRTSDSGMYLCVATN 1154
Query: 209 QALPTGRDT-AITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQP-PVTGYRWAKGGS 266
A G T A+ L++ PP++ VQ G++V C A P PV W+KGGS
Sbjct: 1155 IA---GNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVI--TWSKGGS 1209
Query: 267 PVL-----------GARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQ 315
+L G +DA T C +N G+ L V P ++
Sbjct: 1210 TMLVDGEHHVSNPDGTLSIDQATPSDAGIYT----CVATNIAGTDETEITLHVQEPPTVE 1265
Query: 316 AKPEPVSVDVGEDAS-----FSCAWRGNPLPRVTWTRRG--------GAQVLGSGATLRL 362
P + E + F C +G P P + W G G +L G L +
Sbjct: 1266 DLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVI 1325
Query: 363 PSVGPEDAGDYVCRA--EAGLSGLRGGAAEARLTVNAPPVV---TALHSAPAFLRGPARL 417
SV P D G+Y+C A EAG + + L V+ PPV+ + + L L
Sbjct: 1326 ASVTPYDNGEYICVAVNEAGTT-----ERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNL 1380
Query: 418 QCLVFASPAPDAVVWSWD------EGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHI 471
C V +P+P ++W D ++ + G+ L PE G ++I
Sbjct: 1381 FCEVEGTPSP-IIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYS---CKAINI 1436
Query: 472 SGTQESDFS 480
+GT + F+
Sbjct: 1437 AGTSQKYFN 1445
Score = 91.3 bits (225), Expect = 3e-18
Identities = 83/307 (27%), Positives = 136/307 (44%), Gaps = 27/307 (8%)
Query: 88 LHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 146
L I+ + D Y C A +AG + L V PP Q VS+ G L C
Sbjct: 757 LKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPA--DVSMEIGSNVTLPC 814
Query: 147 RSRGDARPTPELLWFR-DGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCR 205
+G P P + W R D + + F + + + G++ L ++ D G T++C
Sbjct: 815 YVQG--YPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGAL---FILNLWASDKG-TYICE 868
Query: 206 ARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGG 265
A +Q +T +T++ P + +S S V EG+++ C A P+ RW K
Sbjct: 869 AENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNS 928
Query: 266 SPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFGPILQAK 317
+ +L + P + V +D S E V +C SN G+ N++T++ V P +Q
Sbjct: 929 AMLL--QNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHG 986
Query: 318 PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVGPEDA 370
+ +S G + C GNP P V W+++G G+ +L + S G E++
Sbjct: 987 QQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEES 1046
Query: 371 GDYVCRA 377
G+YVC A
Sbjct: 1047 GEYVCTA 1053
Score = 90.1 bits (222), Expect = 6e-18
Identities = 128/544 (23%), Positives = 200/544 (36%), Gaps = 75/544 (13%)
Query: 29 QPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHD 87
+ E L+ L+ + C A G + W K+GL L L R +G
Sbjct: 3348 EAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPL----PLSSHIRLLAAGQV------ 3397
Query: 88 LHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 146
+ I ++ D A Y C A+ +AG+ ++ L V PP +G ++++ G ++ C
Sbjct: 3398 IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC 3457
Query: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 206
+ D P P + W RDG L G H T+ G L L +D + C A
Sbjct: 3458 IT--DGTPAPSMAWLRDGQPL-GLDAHLTVSTHG------MVLQLLKAETEDSGKYTCIA 3508
Query: 207 RSQALPTGRDTAITLSLQYPPEVTLSASPH--TVQEGEKVIFLCQATAQPPVTGYRWAKG 264
++A + L + PP + S +V + C A+ P W K
Sbjct: 3509 SNEAGEVSKH--FILKVLEPPHINGSEEHEEISVIVNNPLELTCIASG-IPAPKMTWMKD 3565
Query: 265 GSPV--------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQA 316
G P+ LG G L + T +C S+ G ++ + V P +
Sbjct: 3566 GRPLPQTDQVQTLGG-GEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAG 3624
Query: 317 KPEPVSVDV--GEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVGP 367
EP + V + C P P +TW R G ++L G L++ +
Sbjct: 3625 TDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADL 3684
Query: 368 EDAGDYVCRAEAGLSGLRGGAA-EARLTVNAPP-VVTALHSAPAFLRGPARLQCLVFASP 425
D +Y C A S + G E LTVN PP + S L L+C+ P
Sbjct: 3685 GDTANYTCVA----SNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVP 3740
Query: 426 APDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNC 485
P + W D G + AG+ R+ + L G LHI +D R + C
Sbjct: 3741 TP-RITWRKD-GAVLAGNHARYSI-----------LENGF---LHIQSAHVTDTGR-YLC 3783
Query: 486 SARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVI-TGVALCCWRHSKASASFS 544
A N G RR + V + +A T + +++ L C S +
Sbjct: 3784 MATNAAG-------TDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSIN 3836
Query: 545 EQKN 548
+KN
Sbjct: 3837 WRKN 3840
Score = 85.9 bits (211), Expect = 1e-16
Identities = 103/439 (23%), Positives = 165/439 (37%), Gaps = 63/439 (14%)
Query: 28 QQPEDLVVLLGEEARLPCAL-GAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQH 86
+Q ++ VLL + L C + G ++ W K + + + N
Sbjct: 1365 EQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTI----------QTVNNGK 1414
Query: 87 DLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLT 145
L + ED Y C+A AG + + VLVPP VS+V L
Sbjct: 1415 ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALE 1474
Query: 146 CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCR 205
C+ +G P P++ WF+DG L + LL G L L +D + C
Sbjct: 1475 CQVKGT--PFPDIHWFKDGKPLFLGDPNVELLDRG------QVLHLKNARRNDKGRYQCT 1526
Query: 206 ARSQALPTGRDTAITLSLQYPPEVTLS--ASPHTVQEGEKVIFLCQATAQPPVTGYRWAK 263
+ A +D I L++ PP + + +V + C+ T P+ W K
Sbjct: 1527 VSNAAGKQAKD--IKLTIYIPPSIKGGNVTTDISVLINSLIKLECE-TRGLPMPAITWYK 1583
Query: 264 GGSPVLGARG------------PRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFG 311
G P++ + PR +V A++ +C V+N G+A +S +DV
Sbjct: 1584 DGQPIMSSSQALYIDKGQYLHIPRAQVSDSATY-----TCHVANVAGTAEKSFHVDVYVP 1638
Query: 312 PILQ---AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLR 361
P+++ A P V + + C GNP P +TW + G ++ G L
Sbjct: 1639 PMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLE 1698
Query: 362 LPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVN--APPVVTALHSAPAFL---RGPAR 416
+ S D G Y+C A + G E + V+ PP + F+
Sbjct: 1699 IMSAQEIDRGQYICVATS-----VAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLE 1753
Query: 417 LQCLVFASPAPDAVVWSWD 435
L C V SP P ++W D
Sbjct: 1754 LDCHVTGSP-PPTIMWLKD 1771
Score = 85.5 bits (210), Expect = 2e-16
Identities = 116/499 (23%), Positives = 186/499 (37%), Gaps = 74/499 (14%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISG--N 80
P + P+ L V +G+ +PC A G ++ W+K G S + G +
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGG------------STMLVDGEHH 1218
Query: 81 AANGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSL--- 136
+N L I D Y C AT AG LHV PP + + +
Sbjct: 1219 VSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQER 1278
Query: 137 VAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSH 196
VA C ++G +PT + W +G L G ++L++GT + S +TP+
Sbjct: 1279 VANQRIEFPCPAKGTPKPT--IKWLHNGRELTGREPGISILEDGTLLVIAS---VTPY-- 1331
Query: 197 DDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE--GEKVIFLCQATAQP 254
D ++C A ++A T R L + PP + V + C+ P
Sbjct: 1332 -DNGEYICVAVNEAGTTERK--YNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTP 1388
Query: 255 -PVTGYRWAKGGSPVLGA-------RGPRLEVVADASFLTEPVSCEVSNAVGSANRSTAL 306
P+ W K V + G L++ SC+ N G++ + +
Sbjct: 1389 SPII--MWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNI 1446
Query: 307 DVLFGPILQAK--PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG--------GAQVLGS 356
DVL P + P VSV + D + C +G P P + W + G ++L
Sbjct: 1447 DVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDR 1506
Query: 357 GATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV---TALHSAPAFLRG 413
G L L + D G Y C + +G + A + +LT+ PP + +
Sbjct: 1507 GQVLHLKNARRNDKGRYQCTV-SNAAGKQ--AKDIKLTIYIPPSIKGGNVTTDISVLINS 1563
Query: 414 PARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISG 473
+L+C P P A+ W D + + SQ ++ +G LHI
Sbjct: 1564 LIKLECETRGLPMP-AITWYKDGQPIMSSSQALYI--------DKG-------QYLHIPR 1607
Query: 474 TQESDFSRSFNCSARNRLG 492
Q SD S ++ C N G
Sbjct: 1608 AQVSD-SATYTCHVANVAG 1625
Score = 81.6 bits (200), Expect = 2e-15
Identities = 131/515 (25%), Positives = 189/515 (36%), Gaps = 90/515 (17%)
Query: 30 PEDLVVLLGEEARLPCALGAYW-GLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDL 88
PED+ V+L L C +Y + W K G L R++ G L
Sbjct: 2582 PEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNI----------RILPGGRTL 2631
Query: 89 HIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQV-LGGPSVS---LVAGVPAN 143
I + ++ Y C AT +AG + ++ V +PP + L GP +S + V
Sbjct: 2632 QILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNT 2691
Query: 144 LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 203
LT A P+ L W++DG L H + G TL + D +
Sbjct: 2692 LTLECEAYAIPSASLSWYKDGQPLKSDD-HVNIAANG------HTLQIKEAQISDTGRYT 2744
Query: 204 CRARSQALPTGRDTA-ITLSLQYPPEVT----LSASPHTVQEGEK--------VIFLCQA 250
C A + A G D +++Q PP + T + GE + C+
Sbjct: 2745 CVASNIA---GEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCET 2801
Query: 251 TAQPPVTGYRWAKGGSPVLGAR-------GPRLEV----VADASFLTEPVSCEVSNAVGS 299
A PP T W K G P+ + G L++ V DA T C N G
Sbjct: 2802 NAAPPPT-LTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYT----CVAVNEAGE 2856
Query: 300 ANRSTALDVLFGPILQAK----PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGA---- 351
+ + VL PI++ PE V+V V + A C G+P PR +W + G
Sbjct: 2857 DSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLED 2916
Query: 352 ---QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAE-ARLTVNAPPVVTALHS- 406
+ L +G L++ + D G YVC AE G A + L V+ PP V S
Sbjct: 2917 DHHKFLSNGRILQILNTQITDIGRYVCVAE----NTAGSAKKYFNLNVHVPPSVIGPKSE 2972
Query: 407 -APAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGL 465
+ L C V P PD SW L+ + T P R
Sbjct: 2973 NLTVVVNNFISLTCEVSGFPPPDL---SW----LKNEQPIKLNTNTLIVPGGR------- 3018
Query: 466 ISVLHISGTQESDFSRSFNCSARNRLGEGGAQASL 500
L I + SD + C A N+ GE + SL
Sbjct: 3019 --TLQIIRAKVSD-GGEYTCIAINQAGESKKKFSL 3050
Score = 79.0 bits (193), Expect = 1e-14
Identities = 122/493 (24%), Positives = 183/493 (37%), Gaps = 72/493 (14%)
Query: 27 LQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQ 85
L P + V++ L C A G ++ W K G+ + ++ G
Sbjct: 1645 LATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNI----------RIEAGG 1694
Query: 86 HDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANL 144
L I + D Y C AT AG + ++ VLVPP + GG S + NL
Sbjct: 1695 KKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPA---IEGGDETSYFIVMVNNL 1751
Query: 145 T---CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 201
C G P P ++W +DG L+D + LL L + +
Sbjct: 1752 LELDCHVTGS--PPPTIMWLKDGQLIDERDGFKILLN-------GRKLVIAQAQVSNTGL 1802
Query: 202 FVCRARSQALPTGRDTAITLSLQYPPEVTLSA-SPHTVQEGEKVIFLCQATAQPPVTGYR 260
+ C A + A ++ +T+ + PP + S S V + + V C A P
Sbjct: 1803 YRCMAANTAGDHKKEFEVTVHV--PPTIKSSGLSERVVVKYKPVALQCIANGIPN-PSIT 1859
Query: 261 WAKGGSPVLGARG-----PRLEVVADASFLTEPV---SCEVSNAVGSANRSTALDVLFGP 312
W K PV A+G V+ A L E +C +NA G + L V P
Sbjct: 1860 WLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPP 1919
Query: 313 ILQ--AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLP 363
L+ K +V V C GNP+P +TW + L G + +
Sbjct: 1920 SLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIE 1979
Query: 364 SVGPEDAGDYVCRAEAGLSGLRGGAAEA--RLTVNAPPVVTALHSAPA-FLRGPARLQCL 420
S DAG Y C A GA E L V+ P ++ ++ A + P RL+C
Sbjct: 1980 SAQISDAGIYKCVAINS-----AGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECE 2034
Query: 421 VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS 480
PAP ++ W D + + S G ++ GG +L ++ Q SD
Sbjct: 2035 ARGIPAP-SLTWLKDGSPVSSFSNGLQVLS--------GG------RILALTSAQISDTG 2079
Query: 481 RSFNCSARNRLGE 493
R + C A N GE
Sbjct: 2080 R-YTCVAVNAAGE 2091
Score = 76.6 bits (187), Expect = 7e-14
Identities = 100/450 (22%), Positives = 170/450 (37%), Gaps = 71/450 (15%)
Query: 21 GPSPHFLQQPEDLVVLLGEEARLPCALGAY-WGLVQWTKSGLALGGQRDLPGWSR-YWIS 78
G P F+Q+P D+ + +G LPC + Y ++W + ++P +SR + +S
Sbjct: 790 GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLD-------NMPIFSRPFSVS 842
Query: 79 GNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSV-SLV 137
+ L I + D+ +Y C+A + + + AP + PSV +++
Sbjct: 843 SISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVI 902
Query: 138 AGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHD 197
G L C P PE W ++ +L + + GS L +
Sbjct: 903 EGQQLTLPCTLLA-GNPIPERRWIKNSAML----LQNPYITVRSDGS----LHIERVQLQ 953
Query: 198 DGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT 257
DG + C A + A + T++ + + P + + EG V C+A+ P
Sbjct: 954 DGGEYTCVASNVAGTNNKTTSVVVHVL--PTIQHGQQILSTIEGIPVTLPCKASGNPK-P 1010
Query: 258 GYRWAKGGSPV--------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVL 309
W+K G + GA G L VV+ + C +N G A R L V
Sbjct: 1011 SVIWSKKGELISTSSAKFSAGADG-SLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVY 1069
Query: 310 FGP--------ILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRR-------GGAQVL 354
P + Q KP +SV GE+ + C + P P +TW +
Sbjct: 1070 VRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTF 1129
Query: 355 GSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEA-RLTVNAPPVVTALHSAPAFLRG 413
++++ D+G Y+C A + + G +A +L V+ PP + RG
Sbjct: 1130 LPSGSMKITETRTSDSGMYLCVA----TNIAGNVTQAVKLNVHVPPKIQ---------RG 1176
Query: 414 PARLQ----------CLVFASPAPDAVVWS 433
P L+ C +P P + WS
Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLP-VITWS 1205
Score = 76.6 bits (187), Expect = 7e-14
Identities = 87/320 (27%), Positives = 126/320 (39%), Gaps = 40/320 (12%)
Query: 84 GQHDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLV---AG 139
G L I ++ D Y C A QAG + L V VPP S+S+V G
Sbjct: 3016 GGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDH-DSESLSVVNVREG 3074
Query: 140 VPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDG 199
+L C S +A P P + W+++G ++ +T H +L +G L + D
Sbjct: 3075 TSVSLECES--NAVPPPVITWYKNGRMITEST-HVEILADG------QMLHIKKAEVSDT 3125
Query: 200 ATFVCRARSQALPTGRDTA-ITLSLQYPPEVTLSASPHTVQE-GEKVIFLCQATAQPPVT 257
+VCRA + A GRD L++ PP + V+ V C AT PP T
Sbjct: 3126 GQYVCRAINVA---GRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPT 3182
Query: 258 GYRWAKG-----GSPVLGAR----GPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDV 308
W K S L R G +L++ + +C SN G A + L +
Sbjct: 3183 -IAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSI 3241
Query: 309 LFGPILQAK--PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG---------GAQVLGSG 357
P + P VSV +GE+ C G P P + W + G +V +G
Sbjct: 3242 QVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG 3301
Query: 358 ATLRLPSVGPEDAGDYVCRA 377
+TL + D G Y C A
Sbjct: 3302 STLNIYGALTSDTGKYTCVA 3321
Score = 69.3 bits (168), Expect = 1e-11
Identities = 97/436 (22%), Positives = 170/436 (38%), Gaps = 65/436 (14%)
Query: 24 PHFLQQPEDLVVLLGEEARLPCAL-GAYWGLVQWTKSGLALGGQRD--LPGWSRYWISGN 80
P +Q P ++ V GE A L C + A + W ++ RD L +R N
Sbjct: 520 PPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRN------DRDVRLAEPARIRTLAN 573
Query: 81 AANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGP-SVSLVAG 139
+ L ++ V+ D Y C + G S + L E P+V P + S G
Sbjct: 574 LS-----LELKSVKFNDAGEYHCMVSSEGGSSAASVF--LTVQEPPKVTVMPKNQSFTGG 626
Query: 140 VPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDG 199
++ C + G P P++ W + + + G+ ++ + + TL + + D
Sbjct: 627 SEVSIMCSATG--YPKPKIAWTVNDMFIVGSHRYRM--------TSDGTLFIKNAAPKDA 676
Query: 200 ATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGY 259
+ C A + A +++ TL P++ + S V G+ + C+ + PP
Sbjct: 677 GIYGCLASNSAGTDKQNS--TLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQ-V 733
Query: 260 RWAKGG-----------SPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDV 308
+W KG P+LG L++ +C N G A LDV
Sbjct: 734 KWFKGDLELRPSTFLIIDPLLGL----LKIQETQDLDAGDYTCVAINEAGRATGKITLDV 789
Query: 309 LFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQV------------LGS 356
P+ +P VS+++G + + C +G P P + W R + L +
Sbjct: 790 GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRT 849
Query: 357 GATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVN--APPVVTALHSAPAFLRG- 413
GA L + ++ D G Y+C AE ++ +E +TV P++ S + G
Sbjct: 850 GA-LFILNLWASDKGTYICEAENQFGKIQ---SETTVTVTGLVAPLIGISPSVANVIEGQ 905
Query: 414 PARLQCLVFA-SPAPD 428
L C + A +P P+
Sbjct: 906 QLTLPCTLLAGNPIPE 921
Score = 68.9 bits (167), Expect = 1e-11
Identities = 88/356 (24%), Positives = 133/356 (37%), Gaps = 47/356 (13%)
Query: 40 EARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDE 98
+A LPC A G + W K + L + A +L + V LED
Sbjct: 4185 QAILPCVADGIPTPAINWKKDNVLLANL----------LGKYTAEPYGELILENVVLEDS 4234
Query: 99 ASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPE 157
Y C A A G + L V V P ++ G VSL G L+C++ G P P+
Sbjct: 4235 GFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG--DVSLNKGEQLRLSCKATGI--PLPK 4290
Query: 158 LLWFRDGVLLDGATFHQTLLKEGTPG-SVESTLTLTPFSHDDGATFVCRARSQALPTGRD 216
L W TF+ ++ + S L + S +D T+VC A + G
Sbjct: 4291 LTW----------TFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSV---GFV 4337
Query: 217 TAITLSLQYPPEVTLSASPHTVQE--GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGP 274
AI P V P E G I C+ P T +W + G + +
Sbjct: 4338 KAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPT-IQWNRKGVDIEISHRI 4396
Query: 275 R------LEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGED 328
R L + + +C +N G RS +L + PI+ +P ++ G
Sbjct: 4397 RQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGK 4456
Query: 329 ASFSCAWRGNPLPRVTWTRRGGA-------QVLGSGATLRLPSVGPEDAGDYVCRA 377
+C G P P +TW+R+G + VL S +L + ED ++ C A
Sbjct: 4457 IILNCQATGEPQPTITWSRQGHSISWDDRVNVL-SNNSLYIADAQKEDTSEFECVA 4511
Score = 68.6 bits (166), Expect = 2e-11
Identities = 105/433 (24%), Positives = 155/433 (35%), Gaps = 67/433 (15%)
Query: 88 LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 146
L I ++ + Y C A AG + ++ V VPP G +V P L C
Sbjct: 1790 LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSS-GLSERVVVKYKPVALQC 1848
Query: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 206
+ G P P + W +D ++ A + + G + TL +D + C A
Sbjct: 1849 IANGI--PNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLL------EDAGRYTCVA 1900
Query: 207 RSQALPTGRDTAITLSLQYPPEVTLSASP--HTVQEGEKVIFLCQATAQPPVTGYRWAKG 264
+ A T + I L + PP + + TV V C+A P V W K
Sbjct: 1901 TNAAGETQQH--IQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNP-VPVITWYKD 1957
Query: 265 GSPVLGA-------RGPRLEV----VADASFLTEPVSCEVSNAVGSANRSTALDVLFGPI 313
+ G+ RG +++ ++DA C N+ G+ +L V P
Sbjct: 1958 NRLLSGSTSMTFLNRGQIIDIESAQISDAGIY----KCVAINSAGATELFYSLQVHVAPS 2013
Query: 314 LQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG--------GAQVLGSGATLRLPSV 365
+ V+V V C RG P P +TW + G G QVL G L L S
Sbjct: 2014 ISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSA 2073
Query: 366 GPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASP 425
D G Y C A +G + + R+ V P ++ + + L C A P
Sbjct: 2074 QISDTGRYTCVA-VNAAGEKQRDIDLRVYV-PPNIMGEEQNVSVLISQAVELLCQSDAIP 2131
Query: 426 APDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLI-----SVLHISGTQESDFS 480
P + W D G L++ PGL SVL I Q D
Sbjct: 2132 -PPTLTWLKD---------GHPLLKK-----------PGLSISENRSVLKIEDAQVQDTG 2170
Query: 481 RSFNCSARNRLGE 493
R + C A N G+
Sbjct: 2171 R-YTCEATNVAGK 2182
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 114 bits (285), Expect = 3e-25
Identities = 119/403 (29%), Positives = 176/403 (43%), Gaps = 51/403 (12%)
Query: 72 WSRYWISGNAANGQH------DLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEA 125
W R W A+ G+ L I + D Y+C A+ A +R A + +LV EA
Sbjct: 433 WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR-ASVWLLVR-EA 490
Query: 126 PQV-LGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDG-VLLDGATFHQTLLKEGTPG 183
PQV + S GV ++C + G PTP + W R+ L + + H
Sbjct: 491 PQVSIHTSSQHFSQGVEVKVSCSASG--YPTPHISWSRESQALQEDSRIHV--------- 539
Query: 184 SVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEK 243
+ TL + + +D + C+A ++ + T ++T +TL PP V+ + V GE+
Sbjct: 540 DAQGTLIIQGVAPEDAGNYSCQATNE-VGTDQET-VTLYYTDPPSVSAVNAVVLVAVGEE 597
Query: 244 VIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVADASFLTEPVSCEVSNAVGS 299
+ +C+A+ PP W +GG ++ G+ +L + A +C N +G
Sbjct: 598 AVLVCEASGVPPPRVI-WYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGD 656
Query: 300 ANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVL----- 354
A+ L V P L P V+V++G A +C G P P VTW RRG Q L
Sbjct: 657 ASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTW-RRGDGQPLGLRLG 715
Query: 355 -GSGATLRLP--------SVGPEDAGDYVCRAEAGLSGLRGGAAEARLTV--NAPPVVTA 403
G G+ R P SV PED YVC A ++ AEARL V +APP + +
Sbjct: 716 AGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQ---AEARLIVTGHAPPQIAS 772
Query: 404 LHSAPAFLRG-PARLQCLVFAS-PAPDAVVWSWDEGFLEAGSQ 444
L G P L C+V A P P+ W D L GS+
Sbjct: 773 SAPTVRVLEGQPVSLPCIVLAGRPLPER-HWLKDGRPLPPGSR 814
Score = 110 bits (275), Expect = 4e-24
Identities = 125/454 (27%), Positives = 183/454 (40%), Gaps = 52/454 (11%)
Query: 83 NGQHDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVP 141
+G I +E +YEC A ++AG AQ+ V PP PQ++ P+V++ G
Sbjct: 359 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPP--PQLVPAPNVTVSPGET 416
Query: 142 ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 201
A L+CR G+A L W RD +L +T L + +L ++ DG
Sbjct: 417 AVLSCRVLGEA--PYNLTWVRDWRVLPASTGRVAQL-------ADLSLEISGIIPTDGGR 467
Query: 202 FVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRW 261
+ C A S A R ++ L ++ P+V++ S +G +V C A+ P W
Sbjct: 468 YQCVA-SNANGVTR-ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY-PTPHISW 524
Query: 262 AKGGSPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFGPI 313
++ + R+ V A + + + V SC+ +N VG+ + L P
Sbjct: 525 SRESQAL--QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 582
Query: 314 LQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVL----GSGATLRLPSVGPED 369
+ A V V VGE+A C G P PRV W R G +L S LR+P+ D
Sbjct: 583 VSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERD 642
Query: 370 AGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTAL-HSAPAFLRGPARLQCLVFASPAPD 428
AG Y CRA ++ L +AE +L V P +T L L A L C P P
Sbjct: 643 AGTYTCRA---VNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRP-PP 698
Query: 429 AVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSAR 488
V W +G G P+S VL D + C AR
Sbjct: 699 TVTWRRGDGQPLGLRLGAGRGSRSRQPDS---------GVLFFESVAPED-QAPYVCEAR 748
Query: 489 NRLGEGGAQASL--------GRRDLLPTVRIVAG 514
N G+ A+A L PTVR++ G
Sbjct: 749 NVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEG 782
Score = 104 bits (259), Expect = 3e-22
Identities = 135/496 (27%), Positives = 190/496 (38%), Gaps = 69/496 (13%)
Query: 33 LVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIR 91
++V +GEEA L C A G V W + GL + I + L I
Sbjct: 590 VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM-------------ILAPEGSSSGKLRIP 636
Query: 92 PVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQVLGGP-SVSLVAGVPANLTCRSR 149
+ D +Y C+A + G S QL V APQ+ P V++ G A L CR+
Sbjct: 637 AAQERDAGTYTCRAVNELGDASAEIQLAV---GHAPQLTELPRDVTVELGRSALLACRAT 693
Query: 150 GDARPTPELLWFR-DGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARS 208
G RP P + W R DG L + P S L + +D A +VC AR+
Sbjct: 694 G--RPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS--GVLFFESVAPEDQAPYVCEARN 749
Query: 209 QALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPV 268
+ + ++ PP++ SA V EG+ V C A P+ W K G P+
Sbjct: 750 VFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL 809
Query: 269 LGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFGPILQAKPEP 320
G R + AD S + SC +N GS +R L V P +
Sbjct: 810 --PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATH 867
Query: 321 VSVDVGEDASFSCAWRGNPLPRVTWTR-------RGGAQVLGSGATLRLPSVGPEDAGDY 373
+ G AS C G P P +TWT+ RG + TL + +DAG Y
Sbjct: 868 HITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAY 927
Query: 374 VCRAEAGLSGLRGGAAEARLTVNAPPVV--TALHSAPAFLRGPAR------LQCLVFASP 425
VC A + + + E RL+VN P + +A L+ A+ L C SP
Sbjct: 928 VCTA---TNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSP 984
Query: 426 APDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNC 485
P V W+ D P +R GL P L ++ Q D S + C
Sbjct: 985 -PPLVTWTKDS-------------RPVPPITNRYGLLPS--GSLRLAQVQVGD-SGHYEC 1027
Query: 486 SARNRLGEGGAQASLG 501
+A N G + LG
Sbjct: 1028 TASNPAGSASHRYVLG 1043
Score = 100 bits (248), Expect = 6e-21
Identities = 109/388 (28%), Positives = 154/388 (39%), Gaps = 55/388 (14%)
Query: 21 GPSPHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKS-----GLALGGQRDLPGWSR 74
G +P + P D+ V LG A L C A G V W + GL LG R SR
Sbjct: 666 GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRG--SRSR 723
Query: 75 YWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVL--GGP 132
SG L V ED+A Y C+A A+ ++V AP + P
Sbjct: 724 QPDSG-------VLFFESVAPEDQAPYVCEARNV-FGKVQAEARLIVTGHAPPQIASSAP 775
Query: 133 SVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLT 192
+V ++ G P +L C RP PE W +DG L + H + +L L
Sbjct: 776 TVRVLEGQPVSLPCIVLA-GRPLPERHWLKDGRPLPPGSRHSI--------RADGSLHLD 826
Query: 193 PFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATA 252
+ + C A + A RD + L +Q PP + +A+ H EG C A+
Sbjct: 827 RALQEHAGRYSCVATNTAGSQHRD--VELVVQVPPRIHPTATHHITNEGVPASLPCVASG 884
Query: 253 QPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRST 304
P T W K + L +RGP V + + L S C +N VG +++
Sbjct: 885 VPAPT-ITWTK-ETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEM 942
Query: 305 ALDVLFGPILQAK-------PEPVSVDVGEDASFSCAWRGNPLPRVTWTR--------RG 349
L V P + P V+ GE+ + C +G+P P VTWT+
Sbjct: 943 RLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITN 1002
Query: 350 GAQVLGSGATLRLPSVGPEDAGDYVCRA 377
+L SG +LRL V D+G Y C A
Sbjct: 1003 RYGLLPSG-SLRLAQVQVGDSGHYECTA 1029
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 114 bits (285), Expect = 3e-25
Identities = 119/403 (29%), Positives = 176/403 (43%), Gaps = 51/403 (12%)
Query: 72 WSRYWISGNAANGQH------DLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEA 125
W R W A+ G+ L I + D Y+C A+ A +R A + +LV EA
Sbjct: 550 WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR-ASVWLLVR-EA 607
Query: 126 PQV-LGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDG-VLLDGATFHQTLLKEGTPG 183
PQV + S GV ++C + G PTP + W R+ L + + H
Sbjct: 608 PQVSIHTSSQHFSQGVEVKVSCSASG--YPTPHISWSRESQALQEDSRIHV--------- 656
Query: 184 SVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEK 243
+ TL + + +D + C+A ++ + T ++T +TL PP V+ + V GE+
Sbjct: 657 DAQGTLIIQGVAPEDAGNYSCQATNE-VGTDQET-VTLYYTDPPSVSAVNAVVLVAVGEE 714
Query: 244 VIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVADASFLTEPVSCEVSNAVGS 299
+ +C+A+ PP W +GG ++ G+ +L + A +C N +G
Sbjct: 715 AVLVCEASGVPPPRVI-WYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGD 773
Query: 300 ANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVL----- 354
A+ L V P L P V+V++G A +C G P P VTW RRG Q L
Sbjct: 774 ASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTW-RRGDGQPLGLRLG 832
Query: 355 -GSGATLRLP--------SVGPEDAGDYVCRAEAGLSGLRGGAAEARLTV--NAPPVVTA 403
G G+ R P SV PED YVC A ++ AEARL V +APP + +
Sbjct: 833 AGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQ---AEARLIVTGHAPPQIAS 889
Query: 404 LHSAPAFLRG-PARLQCLVFAS-PAPDAVVWSWDEGFLEAGSQ 444
L G P L C+V A P P+ W D L GS+
Sbjct: 890 SAPTVRVLEGQPVSLPCIVLAGRPLPER-HWLKDGRPLPPGSR 931
Score = 112 bits (279), Expect = 2e-24
Identities = 137/498 (27%), Positives = 189/498 (37%), Gaps = 68/498 (13%)
Query: 36 LLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLP-GWSRY-WISGNAANGQH------ 86
+ G+ L C A G + W K +G +P GW+ Y W G G H
Sbjct: 1313 MAGQSLTLECDANGFPVPEIVWLKDAQLVG----VPLGWAGYGWDLGWGQVGGHRLLDEG 1368
Query: 87 -DLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANL 144
LH ++ D Y C+A QAG R L VL PP V +AG L
Sbjct: 1369 QSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVEL 1428
Query: 145 TCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVC 204
C + G PTP++ W +D + H + ++G L +T D + C
Sbjct: 1429 QCWTSGV--PTPQVEWTKDRQPVLPGGPHLQVQEDG------QVLRITGSHVGDEGRYQC 1480
Query: 205 RARSQALPTGRDTAITLSLQYPPEVTLS--ASPHTVQEGEKVIFLCQATAQPPVTGYRWA 262
A S A RD L + PP + S V E V LC+A P W
Sbjct: 1481 VAFSPAGQQARD--FQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVP-TPNITWF 1537
Query: 263 KGGS------PVLGARGPR-LEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQ 315
K G+ V+ RG R L++ S +C+ SNAVG+A ++T LDV P ++
Sbjct: 1538 KDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIE 1597
Query: 316 ---AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSV 365
+P V G + C RG+P P ++W G +++ G+ LRL S
Sbjct: 1598 GAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESP 1657
Query: 366 GPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPP---VVTALHSAPAFLRGPARLQCLVF 422
G +G Y C A S + + V PP V L + P L C
Sbjct: 1658 GEASSGLYSCVAS---SPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQAS 1714
Query: 423 ASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRS 482
SP P + W L+ G PA E G + LHI E D S
Sbjct: 1715 GSPVP-TIQW------LQNGR---------PAEELAGVQVASQGTTLHIDHV-ELDHSGL 1757
Query: 483 FNCSARNRLGEGGAQASL 500
F C A N G GA+ +
Sbjct: 1758 FACQATNEAGTAGAEVEV 1775
Score = 110 bits (275), Expect = 4e-24
Identities = 125/454 (27%), Positives = 183/454 (40%), Gaps = 52/454 (11%)
Query: 83 NGQHDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVP 141
+G I +E +YEC A ++AG AQ+ V PP PQ++ P+V++ G
Sbjct: 476 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPP--PQLVPAPNVTVSPGET 533
Query: 142 ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 201
A L+CR G+A L W RD +L +T L + +L ++ DG
Sbjct: 534 AVLSCRVLGEA--PYNLTWVRDWRVLPASTGRVAQL-------ADLSLEISGIIPTDGGR 584
Query: 202 FVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRW 261
+ C A S A R ++ L ++ P+V++ S +G +V C A+ P W
Sbjct: 585 YQCVA-SNANGVTR-ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY-PTPHISW 641
Query: 262 AKGGSPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFGPI 313
++ + R+ V A + + + V SC+ +N VG+ + L P
Sbjct: 642 SRESQAL--QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 699
Query: 314 LQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVL----GSGATLRLPSVGPED 369
+ A V V VGE+A C G P PRV W R G +L S LR+P+ D
Sbjct: 700 VSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERD 759
Query: 370 AGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTAL-HSAPAFLRGPARLQCLVFASPAPD 428
AG Y CRA ++ L +AE +L V P +T L L A L C P P
Sbjct: 760 AGTYTCRA---VNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRP-PP 815
Query: 429 AVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSAR 488
V W +G G P+S VL D + C AR
Sbjct: 816 TVTWRRGDGQPLGLRLGAGRGSRSRQPDS---------GVLFFESVAPED-QAPYVCEAR 865
Query: 489 NRLGEGGAQASL--------GRRDLLPTVRIVAG 514
N G+ A+A L PTVR++ G
Sbjct: 866 NVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEG 899
Score = 107 bits (266), Expect = 5e-23
Identities = 133/490 (27%), Positives = 188/490 (38%), Gaps = 72/490 (14%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P D V + L C + G V W+K+G LG + S Y +S + A
Sbjct: 3857 PTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARG-----SGYRVSPSGA 3911
Query: 83 NGQHDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEA-PQVLGGPSV-SLVAG 139
L I Y C A AG+ A HV + +A P V PSV VA
Sbjct: 3912 -----LEIGQALPIHAGRYTCSARNSAGV----AHKHVFLTVQASPVVKPLPSVVRAVAE 3962
Query: 140 VPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDG 199
L C + G RPT + W ++G+ + Q L PG L + S +D
Sbjct: 3963 EEVLLPCEASGIPRPT--ITWQKEGLNVATGVSTQVL-----PGG---QLRIAHASPEDA 4012
Query: 200 ATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGY 259
++C A++ A T + + Q PP + + EG C+A P
Sbjct: 4013 GNYLCIAKNSAGSAMGKTRLVV--QVPPVIENGLPDLSTTEGSHAFLPCKARGSPE-PNI 4069
Query: 260 RWAKGGSPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFG 311
W K G PV GA G + + L + + +C NAVG A R L +L
Sbjct: 4070 TWDKDGQPVSGAEG-KFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL 4128
Query: 312 PILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-----GAQVLGSGATLRLPSVG 366
P+ P S+ +G+ CA RG+P PR+ WT G G+TL+ +V
Sbjct: 4129 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVS 4188
Query: 367 PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFL----RGPARLQCLVF 422
ED+G YVC AE R G +A V+ A ++L G +L C+V
Sbjct: 4189 REDSGTYVCWAEN-----RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVR 4243
Query: 423 ASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRS 482
P PD + W D G GS R ++ L I T+ D R
Sbjct: 4244 GDPVPD-IHWIKD-GLPLRGSHLRHQLQN---------------GSLTIHRTERDDAGR- 4285
Query: 483 FNCSARNRLG 492
+ C A N +G
Sbjct: 4286 YQCLAENEMG 4295
Score = 102 bits (254), Expect = 1e-21
Identities = 120/446 (26%), Positives = 167/446 (37%), Gaps = 70/446 (15%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P+ P + VL L C A G V W K G + + W +S +
Sbjct: 1886 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFK------GHQPVSSWMGVTVSVDG- 1938
Query: 83 NGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEA--PQVLGGPSVSLVAG 139
L I +L D SY C A+ AG L V VPP P L GP ++
Sbjct: 1939 ---RVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGP---VLVN 1992
Query: 140 VPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVE----STLTLTPFS 195
P LTC + G P+P L+W +DG + A GTPG LTL
Sbjct: 1993 TPVRLTCNATG--APSPTLMWLKDGNPVSPA---------GTPGLQVFPGGRVLTLASAR 2041
Query: 196 HDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPP 255
D + C A S +D + L + PP + +V E V CQ+ A PP
Sbjct: 2042 ASDSGRYSCVAVSAVGEDRQD--VVLQVHMPPSILGEELNVSVVANESVALECQSHAMPP 2099
Query: 256 VTGYRWAKGGSPVLGARGPRLEV-----------VADASFLTEPVSCEVSNAVGSANRST 304
W K G P+ G L V DA T CE N G + +
Sbjct: 2100 PV-LSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYT----CEALNQAGHSEKHY 2154
Query: 305 ALDVLFGPILQAKPE-PVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLR-L 362
L+V P+ + ++V G S SC RG P P+++W R+ G + G GA L+ +
Sbjct: 2155 NLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISW-RKDGQPLPGEGAGLQHV 2213
Query: 363 PSVGP---------EDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR- 412
+VG G Y C + + + + +L V+ PP + P +
Sbjct: 2214 SAVGRLLYLGQAQLAQEGTYTCECS---NVVGNSSQDLQLEVHVPPQIAGPREPPTQVSV 2270
Query: 413 ---GPARLQCLVFASPAPDAVVWSWD 435
G A L+C P P V W D
Sbjct: 2271 VQDGVATLECNATGKP-PPTVTWERD 2295
Score = 101 bits (252), Expect = 2e-21
Identities = 128/483 (26%), Positives = 182/483 (37%), Gaps = 74/483 (15%)
Query: 32 DLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHI 90
D+VV+ G LPC A G LV W K G L Q G S L +
Sbjct: 3415 DVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPS--------------LQL 3460
Query: 91 RPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSR 149
V D +Y C A ++AG R QL V+ PP +SL G P L C ++
Sbjct: 3461 EAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 3520
Query: 150 GDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQ 209
G P P + W +DG Q L + L + D + C A S
Sbjct: 3521 GT--PQPNITWHKDG---------QALTRLENNSRATRVLRVR-----DAGLYTCLAES- 3563
Query: 210 ALPTGR-DTAITLSLQYPPEVTLSASPHTVQ--EGEKVIFLCQATAQPPVTGYRWAKGGS 266
P G + + + +Q PP + P V +++ C A+P W + G
Sbjct: 3564 --PAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEP-APKITWHRDGI 3620
Query: 267 PV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPE 319
+ RG L++ A ++ + SC NA GS + + +++ P +++ P
Sbjct: 3621 VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPP 3680
Query: 320 PVSVDVGEDASFSCAWRGNPLPRVTW--------TRRGGAQVLGSGATLRLPSVGPEDAG 371
V+V V + A C G P P V+W R ++L G +LR+ V +DAG
Sbjct: 3681 AVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG-SLRIQPVLAQDAG 3739
Query: 372 DYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHS-APAFLRGPARLQCLVFASPAPDAV 430
Y+C A R G L V PP + S PA L C SP P V
Sbjct: 3740 HYLCLASNSAGSDRQG---RDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKP-LV 3795
Query: 431 VWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNR 490
VW W +G F + L P +L G Q+ S F C N
Sbjct: 3796 VW-WKDG----------QKLDFRLQQGAYRLLPSNALLLTAPGPQD---SAQFECVVSNE 3841
Query: 491 LGE 493
+GE
Sbjct: 3842 VGE 3844
Score = 99.0 bits (245), Expect = 1e-20
Identities = 137/491 (27%), Positives = 186/491 (37%), Gaps = 73/491 (14%)
Query: 31 EDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLH 89
E++ V L C ALG + W ++GL L L
Sbjct: 2853 EEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRL----------QVLEDGQVLQ 2902
Query: 90 IRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRS 148
+ E+ D ASY C A QAG + L V VPP L V+ + +L C
Sbjct: 2903 VSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAG-LDLEQVTAILNSSVSLPCDV 2961
Query: 149 RGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARS 208
A P PE+ W++D L + + L GT TL L D + C A +
Sbjct: 2962 H--AHPNPEVTWYKDSQAL--SLGEEVFLLPGT-----HTLQLGRARLSDSGMYTCEALN 3012
Query: 209 QALPTGRD-TAITLSLQYPPEVTLSASPHTVQE------GEKVIFLCQATAQPPVTGYRW 261
A GRD + LS+ PP +P Q+ G+K + C+ A P T W
Sbjct: 3013 AA---GRDQKLVQLSVLVPP--AFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-VTW 3066
Query: 262 AKGGSPVLGAR-------GPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPIL 314
K G P++ A+ G RLE+ SC+VSN G A R+ L V P
Sbjct: 3067 YKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTF 3126
Query: 315 Q-AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTR-------RGGAQVLGSGATLRLPSVG 366
+ K E VS G +C G P P VTW + V+ G L+L +
Sbjct: 3127 ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQ 3186
Query: 367 PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPV-VTALHSAPAFLRG-PARLQCLVFAS 424
P AG Y C AE + R A L AP + + + L G RL C
Sbjct: 3187 PAQAGTYTCVAENTQAEARKDFVVAVLV--APRIRSSGVAREHHVLEGQEVRLDCEADGQ 3244
Query: 425 PAPDAVVWSWDEGFL--EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRS 482
P PD V W D L + G RF ++ GG L + G + SD + +
Sbjct: 3245 PPPD-VAWLKDGSPLGQDMGPHLRFYLD--------GG-------SLVLKGLRASD-AGA 3287
Query: 483 FNCSARNRLGE 493
+ C A N GE
Sbjct: 3288 YTCVAHNPAGE 3298
Score = 96.7 bits (239), Expect = 7e-20
Identities = 108/383 (28%), Positives = 152/383 (39%), Gaps = 44/383 (11%)
Query: 33 LVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIR 91
++V +GEEA L C A G V W + GL + I + L I
Sbjct: 707 VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM-------------ILAPEGSSSGKLRIP 753
Query: 92 PVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQVLGGP-SVSLVAGVPANLTCRSR 149
+ D +Y C+A + G S QL V APQ+ P V++ G A L CR+
Sbjct: 754 AAQERDAGTYTCRAVNELGDASAEIQLAV---GHAPQLTELPRDVTVELGRSALLACRAT 810
Query: 150 GDARPTPELLWFR-DGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARS 208
G RP P + W R DG L + P S L + +D A +VC AR+
Sbjct: 811 G--RPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS--GVLFFESVAPEDQAPYVCEARN 866
Query: 209 QALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPV 268
+ + ++ PP++ SA V EG+ V C A P+ W K G P+
Sbjct: 867 VFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL 926
Query: 269 LGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFGPILQAKPEP 320
G R + AD S + SC +N GS +R L V P +
Sbjct: 927 --PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATH 984
Query: 321 VSVDVGEDASFSCAWRGNPLPRVTWTR-------RGGAQVLGSGATLRLPSVGPEDAGDY 373
+ G AS C G P P +TWT+ RG + TL + +DAG Y
Sbjct: 985 HITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAY 1044
Query: 374 VCRAEAGLSGLRGGAAEARLTVN 396
VC A + + + E RL+VN
Sbjct: 1045 VCTA---TNTVGFSSQEMRLSVN 1064
Score = 96.7 bits (239), Expect = 7e-20
Identities = 110/392 (28%), Positives = 153/392 (39%), Gaps = 74/392 (18%)
Query: 88 LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSV-SLVAGVPANLT 145
L + V++ D YEC A+ AG S L V VPP QV GP V ++ G +L
Sbjct: 1084 LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPP---QVQPGPRVLKVLVGEALDLN 1140
Query: 146 CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCR 205
C + G+ P P+L W +DGV+L G G GSV T D + C
Sbjct: 1141 CVAEGN--PEPQLSWSKDGVVLQG---------RGPQGSVHFAAIRT----SDAGRYRCE 1185
Query: 206 ARSQALPTGRDT-AITLSLQYPPEVTLSASPHTVQE--GEKVIFLCQA--TAQPPVTGYR 260
A + A G D + L + PP + ++ GE C A T +P VT
Sbjct: 1186 ASNSA---GVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVT--- 1239
Query: 261 WAKGGSPVLGARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFGP 312
W KG S P + V+ + S VS C+ +N VGS +R L V P
Sbjct: 1240 WRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPP 1299
Query: 313 ILQAKPEPVSVD--VGEDASFSCAWRGNPLPRVTWTRR---------------------- 348
++ +V G+ + C G P+P + W +
Sbjct: 1300 SIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQV 1359
Query: 349 GGAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEA--RLTVNAPPVVTALHS 406
GG ++L G +L P + D+G Y CRAE + G A+ L V PP V +
Sbjct: 1360 GGHRLLDEGQSLHFPRIQEGDSGLYSCRAEN-----QAGTAQRDFHLLVLTPPSVLGAGA 1414
Query: 407 APAFL---RGPARLQCLVFASPAPDAVVWSWD 435
A L LQC P P V W+ D
Sbjct: 1415 AQEVLGLAGADVELQCWTSGVPTPQ-VEWTKD 1445
Score = 95.5 bits (236), Expect = 1e-19
Identities = 132/499 (26%), Positives = 203/499 (40%), Gaps = 84/499 (16%)
Query: 80 NAANGQHDLHIRPVELEDEAS---YECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVS 135
N + + D + +E EAS Y C A+ AG + V VPP+ G V+
Sbjct: 1641 NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVT 1700
Query: 136 LVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFS 195
+ G P L C++ G P P + W ++G + Q + +GT TL +
Sbjct: 1701 TIVGQPLELPCQASGS--PVPTIQWLQNGRPAEELAGVQ-VASQGT------TLHIDHVE 1751
Query: 196 HDDGATFVCRARSQALPTGRDTAITLSLQYPP---EVTLSASPHTVQEGEKVIFLCQ--- 249
D F C+A ++A G + +++ ++ P EV + + C
Sbjct: 1752 LDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPV 1811
Query: 250 -----ATAQPPVT------GYRWAKG-GSPVLGARGPRLEV----VADASFLTEPVSCEV 293
A +PP+ G W + G PV + P L++ + D T C
Sbjct: 1812 HRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYT----CAA 1867
Query: 294 SNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDAS--FSCAWRGNPLPRVTWTRRG-- 349
+N G + R AL VL P ++ P PV+ V E+AS C G P P V+W +
Sbjct: 1868 TNLAGESKREVALKVLVPPNIE--PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQP 1925
Query: 350 -----GAQVLGSGATLRLPSVGPEDAGDYVCRAE--AGLSGLRGGAAEARLTVNAPPVVT 402
G V G LR+ DAG Y C A AG + LR G L VN PP +T
Sbjct: 1926 VSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-----LRVNVPPRIT 1980
Query: 403 ALHS--APAFLRGPARLQCLVFASPAPDAVVWSWDEGFLE-AGSQGRFLVETFPAPESRG 459
S P + P RL C +P+P ++W D + AG+ G ++ FP G
Sbjct: 1981 LPPSLPGPVLVNTPVRLTCNATGAPSP-TLMWLKDGNPVSPAGTPG---LQVFP-----G 2031
Query: 460 GLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAAT 519
G VL ++ + SD R ++C A + +GE R+D++ V + +
Sbjct: 2032 G------RVLTLASARASDSGR-YSCVAVSAVGE-------DRQDVVLQVHMPPSILGEE 2077
Query: 520 TTLLMVIT-GVALCCWRHS 537
+ +V VAL C H+
Sbjct: 2078 LNVSVVANESVALECQSHA 2096
Score = 95.1 bits (235), Expect = 2e-19
Identities = 129/507 (25%), Positives = 190/507 (37%), Gaps = 92/507 (18%)
Query: 27 LQQPEDLVVLLGEEARLPCAL-GAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQ 85
L++ L V G L C G + + W K G L G+ G G
Sbjct: 2166 LRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEG--AGLQHVSAVGRL---- 2219
Query: 86 HDLHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPS-VSLVAGVPAN 143
L++ +L E +Y C+ + G S+ QL V VPP+ P+ VS+V A
Sbjct: 2220 --LYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVAT 2277
Query: 144 LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 203
L C + G +P P + W RDG + GA L +G VE
Sbjct: 2278 LECNATG--KPPPTVTWERDGQPV-GAELGLQLQNQGQSLHVE----------------- 2317
Query: 204 CRARSQALPTGRDTAIT------------LSLQYPPEVTLSASPHT---VQEGEKVIFLC 248
R+QA TGR + + LS+ PPE+ P T + LC
Sbjct: 2318 ---RAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLC 2374
Query: 249 QATAQPPVTGYRWAKGGSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSAN 301
+A PP RW +G PV L A G L++ + SC SN G A
Sbjct: 2375 EAMGIPP-PAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEAR 2433
Query: 302 RSTALDVLFGPILQAKP--EPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLG---- 355
R+ +++VL P ++ + E + V G+ A C G+P P++TW + G G
Sbjct: 2434 RNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHH 2493
Query: 356 ---SGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV------TALHS 406
G L++ AG Y C A + + +L+V P + +A
Sbjct: 2494 ISPDGVLLQVLQANLSSAGHYSCIA---ANAVGEKTKHFQLSVLLAPTILGGAEDSADEE 2550
Query: 407 APAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLI 466
+ P L C A P+P+ + W D EA + L P + G
Sbjct: 2551 VTVTVNNPISLICEALAFPSPN-ITWMKDGAPFEASRNIQLL------PGTHG------- 2596
Query: 467 SVLHISGTQESDFSRSFNCSARNRLGE 493
L I Q+ D + + C N LGE
Sbjct: 2597 --LQILNAQKED-AGQYTCVVTNELGE 2620
Score = 92.8 bits (229), Expect = 1e-18
Identities = 143/531 (26%), Positives = 200/531 (37%), Gaps = 85/531 (16%)
Query: 35 VLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPV 93
VL+ RL C A GA + W K G + PG + G L +
Sbjct: 1989 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVS-PAGTPGLQVF-------PGGRVLTLASA 2040
Query: 94 ELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGP-SVSLVAGVPANLTCRSRGD 151
D Y C A A G + L V +PP +LG +VS+VA L C+S
Sbjct: 2041 RASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS---ILGEELNVSVVANESVALECQSH-- 2095
Query: 152 ARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHD-DGATFVCRARSQA 210
A P P L W++DG L+ + G S + L + D + C A +QA
Sbjct: 2096 AMPPPVLSWWKDGRPLEP--------RPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 2147
Query: 211 LPTGRDTAITLSLQYPPEVTLSASPH-TVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL 269
+ + L++ P L S TV+EG C+ P W K G P+
Sbjct: 2148 GHSEKH--YNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVP-FPKISWRKDGQPLP 2204
Query: 270 GARGP--------RLEVVADASFLTEPV-SCEVSNAVGSANRSTALDVLFGPILQAKPEP 320
G RL + A E +CE SN VG++++ L+V P + EP
Sbjct: 2205 GEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREP 2264
Query: 321 -VSVDVGED--ASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVGPEDA 370
V V +D A+ C G P P VTW R G G Q+ G +L +
Sbjct: 2265 PTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHT 2324
Query: 371 GDYVCRAEAGLSGLRGGA-AEARLTVNAPPVVTA----LHSAPAFLRGPARLQCLVFASP 425
G Y C AE L G A + L+V PP + L + A L P L C P
Sbjct: 2325 GRYSCVAE----NLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIP 2380
Query: 426 APDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNC 485
P A+ W E + G L GG +L ++ TQE D S ++C
Sbjct: 2381 -PPAIRWFRGEEPVSPGEDTYLLA---------GGW------MLKMTQTQEQD-SGLYSC 2423
Query: 486 SARNRLGEGG--------AQASLGRRDLLPTVRIVAGVAAATTTLLMVITG 528
A N GE S+ DL ++++ G T L+ +TG
Sbjct: 2424 LASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDG---QTAHLMCNVTG 2471
Score = 92.4 bits (228), Expect = 1e-18
Identities = 139/559 (24%), Positives = 199/559 (35%), Gaps = 127/559 (22%)
Query: 21 GPSPHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKS-----GLALGGQRDLPGWSR 74
G +P + P D+ V LG A L C A G V W + GL LG R SR
Sbjct: 783 GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRG--SRSR 840
Query: 75 YWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVL--GGP 132
SG L V ED+A Y C+A A+ ++V AP + P
Sbjct: 841 QPDSG-------VLFFESVAPEDQAPYVCEARNV-FGKVQAEARLIVTGHAPPQIASSAP 892
Query: 133 SVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLT 192
+V ++ G P +L C RP PE W +DG L + H + +L L
Sbjct: 893 TVRVLEGQPVSLPCIVLA-GRPLPERHWLKDGRPLPPGSRHSI--------RADGSLHLD 943
Query: 193 PFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATA 252
+ + C A + A RD + L +Q PP + +A+ H EG C A+
Sbjct: 944 RALQEHAGRYSCVATNTAGSQHRD--VELVVQVPPRIHPTATHHITNEGVPASLPCVASG 1001
Query: 253 QPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS--------CEVSNAVG------ 298
P T W K + L +RGP V + + L S C +N VG
Sbjct: 1002 VPAPT-ITWTK-ETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEM 1059
Query: 299 -----------------------------------------------SANRSTALDVLFG 311
SA+ L V
Sbjct: 1060 RLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVP 1119
Query: 312 PILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGA-QVLGSGATLRLPSVGPEDA 370
P +Q P + V VGE +C GNP P+++W++ G Q G ++ ++ DA
Sbjct: 1120 PQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGSVHFAAIRTSDA 1179
Query: 371 GDYVCRA--EAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR---GPARLQCLVFASP 425
G Y C A AG+ A E L V PP A ++ R A L C +P
Sbjct: 1180 GRYRCEASNSAGVD-----AWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTP 1234
Query: 426 APDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISV----LHISGTQESDFSR 481
P +W +G P+ E G PG+ + L ++ +D S
Sbjct: 1235 KPQV---TWRKG---------------PSSEPLHG-QPGVAVLEEGSLFLASVSPAD-SG 1274
Query: 482 SFNCSARNRLGEGGAQASL 500
+ C A N +G +A L
Sbjct: 1275 DYECQATNEVGSTSRRAKL 1293
Score = 88.2 bits (217), Expect = 2e-17
Identities = 103/370 (27%), Positives = 137/370 (37%), Gaps = 42/370 (11%)
Query: 88 LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 146
L I V+L DE Y C AT AG R L VLVPP G + +++ L C
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP--GPVNKAVLENASVTLEC 1907
Query: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLK-EGTPGSVES-TLTLTPFSHDDGATFVC 204
+ G P P++ WF+ HQ + G SV+ L + D ++ C
Sbjct: 1908 LASGV--PPPDVSWFKG---------HQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRC 1956
Query: 205 RARSQALPTGRDTAITLSLQYPPEVTLSAS-PHTVQEGEKVIFLCQATAQPPVTGYRWAK 263
A + A T + L + PP +TL S P V V C AT P T W K
Sbjct: 1957 VASNVAGST--ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT-LMWLK 2013
Query: 264 GGSPVLGARGPRLEVVADASFLTEP---------VSCEVSNAVGSANRSTALDVLFGPIL 314
G+PV A P L+V LT SC +AVG + L V P +
Sbjct: 2014 DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI 2073
Query: 315 QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVGP 367
+ VSV E + C P P ++W + G G + A L++
Sbjct: 2074 LGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADV 2133
Query: 368 EDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR--GPARLQCLVFASP 425
DAG Y C A L+ L V PV S +R P L C P
Sbjct: 2134 WDAGHYTCEA---LNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVP 2190
Query: 426 APDAVVWSWD 435
P + W D
Sbjct: 2191 FP-KISWRKD 2199
Score = 87.4 bits (215), Expect = 4e-17
Identities = 125/490 (25%), Positives = 180/490 (36%), Gaps = 71/490 (14%)
Query: 31 EDLVVLLGEEARLPCALGAYWGL-VQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLH 89
E + +L LPC + A+ V W K AL ++ G H L
Sbjct: 2945 EQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEV----------FLLPGTHTLQ 2994
Query: 90 IRPVELEDEASYECQATQAGLRSRP-AQLHVLVPPEAPQVLGGP--SVSLVAGVPANLTC 146
+ L D Y C+A A R + QL VLVPP Q GP +V + G A L+C
Sbjct: 2995 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSC 3054
Query: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 206
+ DA P P + W++DG L A Q L+ G L + D + C+
Sbjct: 3055 ET--DALPEPTVTWYKDGQPLVLAQRTQA-LRGG------QRLEIQEAQVSDKGLYSCKV 3105
Query: 207 RSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE--GEKVIFLCQATAQPPVTGYRWAKG 264
+ A R TL++Q PP + TV + G ++ C + P T W K
Sbjct: 3106 SNVAGEAVR--TFTLTVQVPPTFE-NPKTETVSQVAGSPLVLTCDVSGVPAPT-VTWLKD 3161
Query: 265 GSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAK 317
PV + +RG RL++ +C N A + + VL P +++
Sbjct: 3162 RMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSS 3221
Query: 318 --PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG--AQVLG-------SGATLRLPSVG 366
V G++ C G P P V W + G Q +G G +L L +
Sbjct: 3222 GVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLR 3281
Query: 367 PEDAGDYVCRAEAGLSGLRGGAAEARL-TVNA---PPVVTALHSAPAFLRGPARLQCLVF 422
DAG Y C A +ARL TVN P + + + P L +V
Sbjct: 3282 ASDAGAYTCVAH------NPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC 3335
Query: 423 ASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRS 482
+ SW L + P P S+ L G L IS Q +D +
Sbjct: 3336 PVRGSPPIHVSW-------------LKDGLPLPLSQRTLLHGSGHTLRISKVQLAD-AGI 3381
Query: 483 FNCSARNRLG 492
F C A + G
Sbjct: 3382 FTCVAASPAG 3391
Score = 87.4 bits (215), Expect = 4e-17
Identities = 111/404 (27%), Positives = 151/404 (37%), Gaps = 61/404 (15%)
Query: 54 VQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYEC-QATQAGLRS 112
V W K GL L P R + G+ H L I V+L D + C A+ AG+
Sbjct: 3345 VSWLKDGLPL------PLSQRTLLHGSG----HTLRISKVQLADAGIFTCVAASPAGVAD 3394
Query: 113 RPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATF 172
R L V VPP V V +V G L C +RG P P + W +DG L +
Sbjct: 3395 RNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARG--VPLPLVSWMKDGEPLLSQSL 3452
Query: 173 HQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLS 232
Q +L L D T+ C A S+A R L++ PP + S
Sbjct: 3453 EQ-----------GPSLQLEAVGAGDSGTYSCVAVSEAGEARRH--FQLTVMEPPHIEDS 3499
Query: 233 ASPH--TVQEGEKVIFLC--QATAQPPVTGYRWAKGGSPVL----GARGPRLEVVADASF 284
P ++ G + LC Q T QP +T W K G + +R R+ V DA
Sbjct: 3500 GQPTELSLTPGAPMELLCDAQGTPQPNIT---WHKDGQALTRLENNSRATRVLRVRDAGL 3556
Query: 285 LTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEP---VSVDVGEDASFSCAWRGNPLP 341
T C + G+ +S + V P + P V + G+ C+ P P
Sbjct: 3557 YT----CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQ-LVLECSVEAEPAP 3611
Query: 342 RVTWTRRG-------GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLT 394
++TW R G Q G L+L ++ D+GDY C A G+
Sbjct: 3612 KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNA-----AGSTSVAFR 3666
Query: 395 VNAPPVVTALHSAPAF---LRGPARLQCLVFASPAPDAVVWSWD 435
V V T PA + A L C PAP V W D
Sbjct: 3667 VEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAP-LVSWRKD 3709
Score = 86.7 bits (213), Expect = 7e-17
Identities = 148/598 (24%), Positives = 208/598 (34%), Gaps = 105/598 (17%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P P L VL+GE L C A G + W+K G+ L G+
Sbjct: 1120 PQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGR---------------- 1163
Query: 83 NGQHDLHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVP 141
Q +H + D Y C+A+ AG+ + +L VL PP + VAG
Sbjct: 1164 GPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGEN 1223
Query: 142 ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 201
A+L C +RG P P++ W + G + + G E +L L S D
Sbjct: 1224 ASLPCPARG--TPKPQVTWRK------GPSSEPLHGQPGVAVLEEGSLFLASVSPADSGD 1275
Query: 202 FVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTV--QEGEKVIFLCQATAQP----- 254
+ C+A ++ T R + + + PP + V G+ + C A P
Sbjct: 1276 YECQATNEVGSTSRRAKLVVYV--PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIV 1333
Query: 255 ----------PV--TGYRWAKGGSPVLGAR----GPRLEVVADASFLTEPVSCEVSNAVG 298
P+ GY W G V G R G L + SC N G
Sbjct: 1334 WLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG 1393
Query: 299 SANRSTALDVLFGPIL--QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTR------RGG 350
+A R L VL P + + V G D C G P P+V WT+ GG
Sbjct: 1394 TAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGG 1453
Query: 351 --AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALH--- 405
QV G LR+ D G Y C A S A + +L V+APP + +
Sbjct: 1454 PHLQVQEDGQVLRITGSHVGDEGRYQCVA---FSPAGQQARDFQLRVHAPPTIWGSNETG 1510
Query: 406 SAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGL 465
+L C P P+ + W D G L + +RGG
Sbjct: 1511 EVAVMEDHLVQLLCEARGVPTPN-ITWFKD---------GALLPTSTKVVYTRGG----- 1555
Query: 466 ISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLL--PTVR-------IVAGVA 516
L + Q SD + + C A N + GA R D+ PT+ +V VA
Sbjct: 1556 -RQLQLGRAQSSD-AGVYTCKASNAV---GAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 1610
Query: 517 AATTTLLMVITG--VALCCWRHSKASASFSEQKNLMRIPGSSDGSSSR--GPEEEETG 570
L V G W H + S + L +DGS R P E +G
Sbjct: 1611 GRPVALECVARGHPSPTLSWHHEGLPVAESNESRL-----ETDGSVLRLESPGEASSG 1663
Score = 85.5 bits (210), Expect = 2e-16
Identities = 105/389 (26%), Positives = 153/389 (39%), Gaps = 56/389 (14%)
Query: 32 DLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHI 90
DL G A LPC A G+ + W K G + G ++ I + +L +
Sbjct: 4046 DLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAE-----GKFTIQPSG-----ELLV 4095
Query: 91 RPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSR 149
+ +E +D +Y C A A G R L +LV P + G S+ L G L C +R
Sbjct: 4096 KNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRL--GDRLWLRCAAR 4153
Query: 150 GDARPTPELLWFRDGVLLDGATFHQTLLKEG-TPGSVESTLTLTPFSHDDGATFVCRARS 208
G PTP + W T + + EG + STL S +D T+VC A +
Sbjct: 4154 GS--PTPRIGW----------TVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAEN 4201
Query: 209 QALPTGRDTAIT-LSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSP 267
+ GR A++ + ++ P + A + V+ I L PV W K G P
Sbjct: 4202 RV---GRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 4258
Query: 268 VLGARGPRLEVVADASFLT---------EPVSCEVSNAVGSANRSTALDVLFGPILQAKP 318
+ RG L LT C N +G A + L + P+ Q +P
Sbjct: 4259 L---RGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEP 4315
Query: 319 EPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLR--------LPSVGPEDA 370
+ ++V G+D + C G P P + W + G Q L + LR L +V DA
Sbjct: 4316 QDMTVRSGDDVALRCQATGEPTPTIEWLQAG--QPLRASRRLRTLPDGSLWLENVETGDA 4373
Query: 371 GDYVCRAEAGLSGLRGGAAEARLTVNAPP 399
G Y C A + L A A L V P
Sbjct: 4374 GTYDCVAH---NLLGSATARAFLVVRGEP 4399
Score = 78.2 bits (191), Expect = 2e-14
Identities = 100/372 (26%), Positives = 144/372 (38%), Gaps = 54/372 (14%)
Query: 88 LHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 146
L ++ + D Y C A A G S ++ + P G P+V++ A L C
Sbjct: 3637 LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS--GPPAVNVSVNQTALLPC 3694
Query: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 206
++ D P P + W +D V LD + +L EG+ L + P D ++C A
Sbjct: 3695 QA--DGVPAPLVSWRKDRVPLDPRSPRFEILPEGS-------LRIQPVLAQDAGHYLCLA 3745
Query: 207 RSQALPT--GRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKG 264
+ A GRD L + PP + S S T+ + C+A+ P W G
Sbjct: 3746 SNSAGSDRQGRD----LRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDG 3801
Query: 265 GSPVLGAR-GPRLEVVADASFLTEP-------VSCEVSNAVGSANRSTALDVLFGPILQA 316
+ G + ++A LT P C VSN VG A+R + V P +
Sbjct: 3802 QKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIAD 3861
Query: 317 KPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG--------GAQVLGSGATLRLPSVGPE 368
+V + +C G P P V+W++ G G +V SGA L + P
Sbjct: 3862 DQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGA-LEIGQALPI 3920
Query: 369 DAGDYVCRAEAGLSGLRGGAAEAR----LTVNAPPVVTALHSAPAFLRGPAR----LQCL 420
AG Y C A R A A LTV A PVV L P+ +R A L C
Sbjct: 3921 HAGRYTCSA-------RNSAGVAHKHVFLTVQASPVVKPL---PSVVRAVAEEEVLLPCE 3970
Query: 421 VFASPAPDAVVW 432
P P + W
Sbjct: 3971 ASGIPRP-TITW 3981
Score = 71.6 bits (174), Expect = 2e-12
Identities = 111/474 (23%), Positives = 174/474 (36%), Gaps = 89/474 (18%)
Query: 70 PGWSRYWISGNAANGQHDLHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQV 128
PG Y ++G L + + +D Y C A+ +AG R + VLVPP
Sbjct: 2395 PGEDTYLLAGGWM-----LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENE 2449
Query: 129 LGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVEST 188
+ ++ G A+L C G P P+L WF+DG L H +P V
Sbjct: 2450 DLEEVIKVLDGQTAHLMCNVTG--HPQPKLTWFKDGRPLARGDAHHI-----SPDGV--L 2500
Query: 189 LTLTPFSHDDGATFVCRARSQALPTGRDTA-ITLSLQYPPEVTLSASPH-----TVQEGE 242
L + + + C A A G T LS+ P + A TV
Sbjct: 2501 LQVLQANLSSAGHYSCIA---ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNN 2557
Query: 243 KVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRL-------EVVADASFLTEPVSCEVSN 295
+ +C+A A P W K G+P +R +L +++ +C V+N
Sbjct: 2558 PISLICEALAFPS-PNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTN 2616
Query: 296 AVGSANRSTALDVLFGPILQAKPEP--------VSVDVGEDASFSCAWRGNPLPRVTWTR 347
+G A ++ ++VL P + +K +P V V + C P P + W +
Sbjct: 2617 ELGEAVKNYHVEVLIPPSI-SKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYK 2675
Query: 348 RGGA-------QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPV 400
G QVLG G L++ D+G Y+C A ++G + + + PP+
Sbjct: 2676 DGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVA-TNVAG--EDDQDFNVLIQVPPM 2732
Query: 401 VTALHSAPAFL---------------------RGPARLQCLVFASPAPDAVVWSWDEGFL 439
+ A PA L C A P PD + W ++ L
Sbjct: 2733 FQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPD-LTWYREDQPL 2791
Query: 440 EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGE 493
AG + L +GG VL I + + R ++C A N +GE
Sbjct: 2792 SAGDEVSVL---------QGG------RVLQIPLVRAENAGR-YSCKASNEVGE 2829
Score = 69.7 bits (169), Expect = 9e-12
Identities = 119/458 (25%), Positives = 163/458 (35%), Gaps = 93/458 (20%)
Query: 88 LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPP----------------EAPQVLG 130
L I+P ++ D Y C AT AG + + + VPP + G
Sbjct: 2695 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARG 2754
Query: 131 GPSV--SLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVEST 188
G + +V PA L C + +A P P+L W+R+ L A ++L+ G
Sbjct: 2755 GVTEYREIVENNPAYLYCDT--NAIPPPDLTWYREDQPL-SAGDEVSVLQGG------RV 2805
Query: 189 LTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE-----GEK 243
L + ++ + C+A ++ G D L P V L + V+E
Sbjct: 2806 LQIPLVRAENAGRYSCKASNE---VGEDWLHYELLVLTPPVILGDTEELVEEVTVNASST 2862
Query: 244 VIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS---------CEVS 294
V C A PV W + G P + PRL+V+ D L + C
Sbjct: 2863 VSLQCPALGN-PVPTISWLQNGLPF--SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAE 2919
Query: 295 NAVGSANRSTALDVLFGP-ILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQV 353
N GSA + L V P I E V+ + S C +P P VTW + A
Sbjct: 2920 NQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALS 2979
Query: 354 LGSGA-------TLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHS 406
LG TL+L D+G Y C A L+ +L+V PP A
Sbjct: 2980 LGEEVFLLPGTHTLQLGRARLSDSGMYTCEA---LNAAGRDQKLVQLSVLVPP---AFRQ 3033
Query: 407 APAFLRGP-----------ARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAP 455
AP RGP A L C A P P V W D G+ LV
Sbjct: 3034 AP---RGPQDAVLVRVGDKAVLSCETDALPEP-TVTWYKD---------GQPLVLAQRTQ 3080
Query: 456 ESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGE 493
RGG L I Q SD ++C N GE
Sbjct: 3081 ALRGG------QRLEIQEAQVSD-KGLYSCKVSNVAGE 3111
Score = 32.7 bits (73), Expect = 1.2
Identities = 33/118 (27%), Positives = 52/118 (44%), Gaps = 14/118 (11%)
Query: 23 SPHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNA 81
+P F +P+D+ V G++ L C A G ++W ++G L R L R G+
Sbjct: 4308 APVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRL----RTLPDGS- 4362
Query: 82 ANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAG 139
L + VE D +Y+C A L S A+ ++V E PQ G ++ G
Sbjct: 4363 ------LWLENVETGDAGTYDCVAHNL-LGSATARAFLVVRGE-PQGSWGSMTGVING 4412
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 112 bits (279), Expect = 2e-24
Identities = 137/498 (27%), Positives = 189/498 (37%), Gaps = 68/498 (13%)
Query: 36 LLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLP-GWSRY-WISGNAANGQH------ 86
+ G+ L C A G + W K +G +P GW+ Y W G G H
Sbjct: 31 MAGQSLTLECDANGFPVPEIVWLKDAQLVG----VPLGWAGYGWDLGWGQVGGHRLLDEG 86
Query: 87 -DLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANL 144
LH ++ D Y C+A QAG R L VL PP V +AG L
Sbjct: 87 QSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVEL 146
Query: 145 TCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVC 204
C + G PTP++ W +D + H + ++G L +T D + C
Sbjct: 147 QCWTSGV--PTPQVEWTKDRQPVLPGGPHLQVQEDG------QVLRITGSHVGDEGRYQC 198
Query: 205 RARSQALPTGRDTAITLSLQYPPEVTLS--ASPHTVQEGEKVIFLCQATAQPPVTGYRWA 262
A S A RD L + PP + S V E V LC+A P W
Sbjct: 199 VAFSPAGQQARD--FQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVP-TPNITWF 255
Query: 263 KGGS------PVLGARGPR-LEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQ 315
K G+ V+ RG R L++ S +C+ SNAVG+A ++T LDV P ++
Sbjct: 256 KDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIE 315
Query: 316 ---AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSV 365
+P V G + C RG+P P ++W G +++ G+ LRL S
Sbjct: 316 GAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESP 375
Query: 366 GPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPP---VVTALHSAPAFLRGPARLQCLVF 422
G +G Y C A S + + V PP V L + P L C
Sbjct: 376 GEASSGLYSCVAS---SPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQAS 432
Query: 423 ASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRS 482
SP P + W L+ G PA E G + LHI E D S
Sbjct: 433 GSPVP-TIQW------LQNGR---------PAEELAGVQVASQGTTLHIDHV-ELDHSGL 475
Query: 483 FNCSARNRLGEGGAQASL 500
F C A N G GA+ +
Sbjct: 476 FACQATNEAGTAGAEVEV 493
Score = 107 bits (266), Expect = 5e-23
Identities = 133/490 (27%), Positives = 188/490 (38%), Gaps = 72/490 (14%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P D V + L C + G V W+K+G LG + S Y +S + A
Sbjct: 2575 PTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARG-----SGYRVSPSGA 2629
Query: 83 NGQHDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEA-PQVLGGPSV-SLVAG 139
L I Y C A AG+ A HV + +A P V PSV VA
Sbjct: 2630 -----LEIGQALPIHAGRYTCSARNSAGV----AHKHVFLTVQASPVVKPLPSVVRAVAE 2680
Query: 140 VPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDG 199
L C + G RPT + W ++G+ + Q L PG L + S +D
Sbjct: 2681 EEVLLPCEASGIPRPT--ITWQKEGLNVATGVSTQVL-----PGG---QLRIAHASPEDA 2730
Query: 200 ATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGY 259
++C A++ A T + + Q PP + + EG C+A P
Sbjct: 2731 GNYLCIAKNSAGSAMGKTRLVV--QVPPVIENGLPDLSTTEGSHAFLPCKARGSPE-PNI 2787
Query: 260 RWAKGGSPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFG 311
W K G PV GA G + + L + + +C NAVG A R L +L
Sbjct: 2788 TWDKDGQPVSGAEG-KFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL 2846
Query: 312 PILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-----GAQVLGSGATLRLPSVG 366
P+ P S+ +G+ CA RG+P PR+ WT G G+TL+ +V
Sbjct: 2847 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVS 2906
Query: 367 PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFL----RGPARLQCLVF 422
ED+G YVC AE R G +A V+ A ++L G +L C+V
Sbjct: 2907 REDSGTYVCWAEN-----RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVR 2961
Query: 423 ASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRS 482
P PD + W D G GS R ++ L I T+ D R
Sbjct: 2962 GDPVPD-IHWIKD-GLPLRGSHLRHQLQN---------------GSLTIRRTERDDAGR- 3003
Query: 483 FNCSARNRLG 492
+ C A N +G
Sbjct: 3004 YQCLAENEMG 3013
Score = 101 bits (252), Expect = 2e-21
Identities = 128/483 (26%), Positives = 182/483 (37%), Gaps = 74/483 (15%)
Query: 32 DLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHI 90
D+VV+ G LPC A G LV W K G L Q G S L +
Sbjct: 2133 DVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPS--------------LQL 2178
Query: 91 RPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSR 149
V D +Y C A ++AG R QL V+ PP +SL G P L C ++
Sbjct: 2179 EAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 2238
Query: 150 GDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQ 209
G P P + W +DG Q L + L + D + C A S
Sbjct: 2239 GT--PQPNITWHKDG---------QALTRLENNSRATRVLRVR-----DAGLYTCLAES- 2281
Query: 210 ALPTGR-DTAITLSLQYPPEVTLSASPHTVQ--EGEKVIFLCQATAQPPVTGYRWAKGGS 266
P G + + + +Q PP + P V +++ C A+P W + G
Sbjct: 2282 --PAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEP-APKITWHRDGI 2338
Query: 267 PV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPE 319
+ RG L++ A ++ + SC NA GS + + +++ P +++ P
Sbjct: 2339 VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPP 2398
Query: 320 PVSVDVGEDASFSCAWRGNPLPRVTW--------TRRGGAQVLGSGATLRLPSVGPEDAG 371
V+V V + A C G P P V+W R ++L G +LR+ V +DAG
Sbjct: 2399 AVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG-SLRIQPVLAQDAG 2457
Query: 372 DYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHS-APAFLRGPARLQCLVFASPAPDAV 430
Y+C A R G L V PP + S PA L C SP P V
Sbjct: 2458 HYLCLASNSAGSDRQG---RDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKP-LV 2513
Query: 431 VWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNR 490
VW W +G F + L P +L G Q+ S F C N
Sbjct: 2514 VW-WKDG----------QKLDFRLQQGAYRLLPSNALLLTAPGPQD---SAQFECVVSNE 2559
Query: 491 LGE 493
+GE
Sbjct: 2560 VGE 2562
Score = 100 bits (249), Expect = 5e-21
Identities = 119/446 (26%), Positives = 166/446 (37%), Gaps = 70/446 (15%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P+ P + VL L C A G V W K G + + W +S +
Sbjct: 604 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFK------GHQPVSSWMGVTVSVDG- 656
Query: 83 NGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEA--PQVLGGPSVSLVAG 139
L I +L D SY C A+ AG L V VPP P L GP ++
Sbjct: 657 ---RVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGP---VLVN 710
Query: 140 VPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVE----STLTLTPFS 195
P LTC + G P+P L+W +DG + A GTPG LTL
Sbjct: 711 TPVRLTCNATG--APSPTLMWLKDGNPVSPA---------GTPGLQVFPGGRVLTLASAR 759
Query: 196 HDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPP 255
D + C A S +D + L + PP + +V E V CQ+ A PP
Sbjct: 760 ASDSGRYSCVAVSAVGEDRQD--VVLQVHMPPSILGEELNVSVVANESVALECQSHAMPP 817
Query: 256 VTGYRWAKGGSPVLGARGPRLEV-----------VADASFLTEPVSCEVSNAVGSANRST 304
W K G P+ G L V DA T CE N G + +
Sbjct: 818 PV-LSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYT----CEALNQAGHSEKHY 872
Query: 305 ALDVLFGPILQAKPE-PVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLR-L 362
L+V P+ + ++V G SC RG P P+++W R+ G + G GA L+ +
Sbjct: 873 NLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISW-RKDGQPLPGEGAGLQHV 931
Query: 363 PSVGP---------EDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR- 412
+VG G Y C + + + + +L V+ PP + P +
Sbjct: 932 SAVGRLLYLGQAQLAQEGTYTCECS---NVVGNSSQDLQLEVHVPPQIAGPREPPTQVSV 988
Query: 413 ---GPARLQCLVFASPAPDAVVWSWD 435
G A L+C P P V W D
Sbjct: 989 VQDGVATLECNATGKP-PPTVTWERD 1013
Score = 99.0 bits (245), Expect = 1e-20
Identities = 137/491 (27%), Positives = 186/491 (37%), Gaps = 73/491 (14%)
Query: 31 EDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLH 89
E++ V L C ALG + W ++GL L L
Sbjct: 1571 EEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRL----------QVLEDGQVLQ 1620
Query: 90 IRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRS 148
+ E+ D ASY C A QAG + L V VPP L V+ + +L C
Sbjct: 1621 VSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAG-LDLEQVTAILNSSVSLPCDV 1679
Query: 149 RGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARS 208
A P PE+ W++D L + + L GT TL L D + C A +
Sbjct: 1680 H--AHPNPEVTWYKDSQAL--SLGEEVFLLPGT-----HTLQLGRARLSDSGMYTCEALN 1730
Query: 209 QALPTGRD-TAITLSLQYPPEVTLSASPHTVQE------GEKVIFLCQATAQPPVTGYRW 261
A GRD + LS+ PP +P Q+ G+K + C+ A P T W
Sbjct: 1731 AA---GRDQKLVQLSVLVPP--AFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-VTW 1784
Query: 262 AKGGSPVLGAR-------GPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPIL 314
K G P++ A+ G RLE+ SC+VSN G A R+ L V P
Sbjct: 1785 YKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTF 1844
Query: 315 Q-AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTR-------RGGAQVLGSGATLRLPSVG 366
+ K E VS G +C G P P VTW + V+ G L+L +
Sbjct: 1845 ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQ 1904
Query: 367 PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPV-VTALHSAPAFLRG-PARLQCLVFAS 424
P AG Y C AE + R A L AP + + + L G RL C
Sbjct: 1905 PAQAGTYTCVAENTQAEARKDFVVAVLV--APRIRSSGVAREHHVLEGQEVRLDCEADGQ 1962
Query: 425 PAPDAVVWSWDEGFL--EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRS 482
P PD V W D L + G RF ++ GG L + G + SD + +
Sbjct: 1963 PPPD-VAWLKDGSPLGQDMGPHLRFYLD--------GG-------SLVLKGLRASD-AGA 2005
Query: 483 FNCSARNRLGE 493
+ C A N GE
Sbjct: 2006 YTCVAHNPAGE 2016
Score = 97.4 bits (241), Expect = 4e-20
Identities = 130/507 (25%), Positives = 191/507 (37%), Gaps = 92/507 (18%)
Query: 27 LQQPEDLVVLLGEEARLPCAL-GAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQ 85
L++ L V G RL C G + + W K G L G+ G G
Sbjct: 884 LRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEG--AGLQHVSAVGRL---- 937
Query: 86 HDLHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPS-VSLVAGVPAN 143
L++ +L E +Y C+ + G S+ QL V VPP+ P+ VS+V A
Sbjct: 938 --LYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVAT 995
Query: 144 LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 203
L C + G +P P + W RDG + GA L +G VE
Sbjct: 996 LECNATG--KPPPTVTWERDGQPV-GAELGLQLQNQGQSLHVE----------------- 1035
Query: 204 CRARSQALPTGRDTAIT------------LSLQYPPEVTLSASPHT---VQEGEKVIFLC 248
R+QA TGR + + LS+ PPE+ P T + LC
Sbjct: 1036 ---RAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLC 1092
Query: 249 QATAQPPVTGYRWAKGGSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSAN 301
+A PP RW +G PV L A G L++ + SC SN G A
Sbjct: 1093 EAMGIPP-PAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEAR 1151
Query: 302 RSTALDVLFGPILQAKP--EPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLG---- 355
R+ +++VL P ++ + E + V G+ A C G+P P++TW + G G
Sbjct: 1152 RNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHH 1211
Query: 356 ---SGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV------TALHS 406
G L++ AG Y C A + + +L+V P + +A
Sbjct: 1212 ISPDGVLLQVLQANLSSAGHYSCIA---ANAVGEKTKHFQLSVLLAPTILGGAEDSADEE 1268
Query: 407 APAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLI 466
+ P L C A P+P+ + W D EA + L P + G
Sbjct: 1269 VTVTVNNPISLICEALAFPSPN-ITWMKDGAPFEASRNIQLL------PGTHG------- 1314
Query: 467 SVLHISGTQESDFSRSFNCSARNRLGE 493
L I Q+ D + + C N LGE
Sbjct: 1315 --LQILNAQKED-AGQYTCVVTNELGE 1338
Score = 95.5 bits (236), Expect = 1e-19
Identities = 132/499 (26%), Positives = 203/499 (40%), Gaps = 84/499 (16%)
Query: 80 NAANGQHDLHIRPVELEDEAS---YECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVS 135
N + + D + +E EAS Y C A+ AG + V VPP+ G V+
Sbjct: 359 NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVT 418
Query: 136 LVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFS 195
+ G P L C++ G P P + W ++G + Q + +GT TL +
Sbjct: 419 TIVGQPLELPCQASGS--PVPTIQWLQNGRPAEELAGVQ-VASQGT------TLHIDHVE 469
Query: 196 HDDGATFVCRARSQALPTGRDTAITLSLQYPP---EVTLSASPHTVQEGEKVIFLCQ--- 249
D F C+A ++A G + +++ ++ P EV + + C
Sbjct: 470 LDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPV 529
Query: 250 -----ATAQPPVT------GYRWAKG-GSPVLGARGPRLEV----VADASFLTEPVSCEV 293
A +PP+ G W + G PV + P L++ + D T C
Sbjct: 530 HRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYT----CAA 585
Query: 294 SNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDAS--FSCAWRGNPLPRVTWTRRG-- 349
+N G + R AL VL P ++ P PV+ V E+AS C G P P V+W +
Sbjct: 586 TNLAGESKREVALKVLVPPNIE--PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQP 643
Query: 350 -----GAQVLGSGATLRLPSVGPEDAGDYVCRAE--AGLSGLRGGAAEARLTVNAPPVVT 402
G V G LR+ DAG Y C A AG + LR G L VN PP +T
Sbjct: 644 VSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-----LRVNVPPRIT 698
Query: 403 ALHS--APAFLRGPARLQCLVFASPAPDAVVWSWDEGFLE-AGSQGRFLVETFPAPESRG 459
S P + P RL C +P+P ++W D + AG+ G ++ FP G
Sbjct: 699 LPPSLPGPVLVNTPVRLTCNATGAPSP-TLMWLKDGNPVSPAGTPG---LQVFP-----G 749
Query: 460 GLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAAT 519
G VL ++ + SD R ++C A + +GE R+D++ V + +
Sbjct: 750 G------RVLTLASARASDSGR-YSCVAVSAVGE-------DRQDVVLQVHMPPSILGEE 795
Query: 520 TTLLMVIT-GVALCCWRHS 537
+ +V VAL C H+
Sbjct: 796 LNVSVVANESVALECQSHA 814
Score = 92.4 bits (228), Expect = 1e-18
Identities = 143/531 (26%), Positives = 200/531 (37%), Gaps = 85/531 (16%)
Query: 35 VLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPV 93
VL+ RL C A GA + W K G + PG + G L +
Sbjct: 707 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVS-PAGTPGLQVF-------PGGRVLTLASA 758
Query: 94 ELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGP-SVSLVAGVPANLTCRSRGD 151
D Y C A A G + L V +PP +LG +VS+VA L C+S
Sbjct: 759 RASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS---ILGEELNVSVVANESVALECQSH-- 813
Query: 152 ARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHD-DGATFVCRARSQA 210
A P P L W++DG L+ + G S + L + D + C A +QA
Sbjct: 814 AMPPPVLSWWKDGRPLEP--------RPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 865
Query: 211 LPTGRDTAITLSLQYPPEVTLSASPH-TVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL 269
+ + L++ P L S TV+EG C+ P W K G P+
Sbjct: 866 GHSEKH--YNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVP-FPKISWRKDGQPLP 922
Query: 270 GARGP--------RLEVVADASFLTEPV-SCEVSNAVGSANRSTALDVLFGPILQAKPEP 320
G RL + A E +CE SN VG++++ L+V P + EP
Sbjct: 923 GEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREP 982
Query: 321 -VSVDVGED--ASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVGPEDA 370
V V +D A+ C G P P VTW R G G Q+ G +L +
Sbjct: 983 PTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHT 1042
Query: 371 GDYVCRAEAGLSGLRGGA-AEARLTVNAPPVVTA----LHSAPAFLRGPARLQCLVFASP 425
G Y C AE L G A + L+V PP + L + A L P L C P
Sbjct: 1043 GRYSCVAE----NLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIP 1098
Query: 426 APDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNC 485
P A+ W E + G L GG +L ++ TQE D S ++C
Sbjct: 1099 -PPAIRWFRGEEPVSPGEDTYLLA---------GGW------MLKMTQTQEQD-SGLYSC 1141
Query: 486 SARNRLGEGG--------AQASLGRRDLLPTVRIVAGVAAATTTLLMVITG 528
A N GE S+ DL ++++ G T L+ +TG
Sbjct: 1142 LASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDG---QTAHLMCNVTG 1189
Score = 90.5 bits (223), Expect = 5e-18
Identities = 104/370 (28%), Positives = 138/370 (37%), Gaps = 42/370 (11%)
Query: 88 LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 146
L I V+L DE Y C AT AG R L VLVPP G + +++ L C
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP--GPVNKAVLENASVTLEC 625
Query: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLK-EGTPGSVES-TLTLTPFSHDDGATFVC 204
+ G P P++ WF+ HQ + G SV+ L + D ++ C
Sbjct: 626 LASGV--PPPDVSWFKG---------HQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRC 674
Query: 205 RARSQALPTGRDTAITLSLQYPPEVTLSAS-PHTVQEGEKVIFLCQATAQPPVTGYRWAK 263
A + A T + L + PP +TL S P V V C AT P T W K
Sbjct: 675 VASNVAGST--ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT-LMWLK 731
Query: 264 GGSPVLGARGPRLEVVADASFLTEP---------VSCEVSNAVGSANRSTALDVLFGPIL 314
G+PV A P L+V LT SC +AVG + L V P +
Sbjct: 732 DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI 791
Query: 315 QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVGP 367
+ VSV E + C P P ++W + G G + A L++
Sbjct: 792 LGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADV 851
Query: 368 EDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR--GPARLQCLVFASP 425
DAG Y C A L+ L V PV S +R P RL C P
Sbjct: 852 WDAGHYTCEA---LNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVP 908
Query: 426 APDAVVWSWD 435
P + W D
Sbjct: 909 FP-KISWRKD 917
Score = 87.4 bits (215), Expect = 4e-17
Identities = 125/490 (25%), Positives = 180/490 (36%), Gaps = 71/490 (14%)
Query: 31 EDLVVLLGEEARLPCALGAYWGL-VQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLH 89
E + +L LPC + A+ V W K AL ++ G H L
Sbjct: 1663 EQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEV----------FLLPGTHTLQ 1712
Query: 90 IRPVELEDEASYECQATQAGLRSRP-AQLHVLVPPEAPQVLGGP--SVSLVAGVPANLTC 146
+ L D Y C+A A R + QL VLVPP Q GP +V + G A L+C
Sbjct: 1713 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSC 1772
Query: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 206
+ DA P P + W++DG L A Q L+ G L + D + C+
Sbjct: 1773 ET--DALPEPTVTWYKDGQPLVLAQRTQA-LRGG------QRLEIQEAQVSDKGLYSCKV 1823
Query: 207 RSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE--GEKVIFLCQATAQPPVTGYRWAKG 264
+ A R TL++Q PP + TV + G ++ C + P T W K
Sbjct: 1824 SNVAGEAVR--TFTLTVQVPPTFE-NPKTETVSQVAGSPLVLTCDVSGVPAPT-VTWLKD 1879
Query: 265 GSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAK 317
PV + +RG RL++ +C N A + + VL P +++
Sbjct: 1880 RMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSS 1939
Query: 318 --PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG--AQVLG-------SGATLRLPSVG 366
V G++ C G P P V W + G Q +G G +L L +
Sbjct: 1940 GVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLR 1999
Query: 367 PEDAGDYVCRAEAGLSGLRGGAAEARL-TVNA---PPVVTALHSAPAFLRGPARLQCLVF 422
DAG Y C A +ARL TVN P + + + P L +V
Sbjct: 2000 ASDAGAYTCVAH------NPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC 2053
Query: 423 ASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRS 482
+ SW L + P P S+ L G L IS Q +D +
Sbjct: 2054 PVRGSPPIHVSW-------------LKDGLPLPLSQRTLLHGSGHTLRISKVQLAD-AGI 2099
Query: 483 FNCSARNRLG 492
F C A + G
Sbjct: 2100 FTCVAASPAG 2109
Score = 87.4 bits (215), Expect = 4e-17
Identities = 111/404 (27%), Positives = 151/404 (37%), Gaps = 61/404 (15%)
Query: 54 VQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYEC-QATQAGLRS 112
V W K GL L P R + G+ H L I V+L D + C A+ AG+
Sbjct: 2063 VSWLKDGLPL------PLSQRTLLHGSG----HTLRISKVQLADAGIFTCVAASPAGVAD 2112
Query: 113 RPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATF 172
R L V VPP V V +V G L C +RG P P + W +DG L +
Sbjct: 2113 RNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARG--VPLPLVSWMKDGEPLLSQSL 2170
Query: 173 HQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLS 232
Q +L L D T+ C A S+A R L++ PP + S
Sbjct: 2171 EQ-----------GPSLQLEAVGAGDSGTYSCVAVSEAGEARRH--FQLTVMEPPHIEDS 2217
Query: 233 ASPH--TVQEGEKVIFLC--QATAQPPVTGYRWAKGGSPVL----GARGPRLEVVADASF 284
P ++ G + LC Q T QP +T W K G + +R R+ V DA
Sbjct: 2218 GQPTELSLTPGAPMELLCDAQGTPQPNIT---WHKDGQALTRLENNSRATRVLRVRDAGL 2274
Query: 285 LTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEP---VSVDVGEDASFSCAWRGNPLP 341
T C + G+ +S + V P + P V + G+ C+ P P
Sbjct: 2275 YT----CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQ-LVLECSVEAEPAP 2329
Query: 342 RVTWTRRG-------GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLT 394
++TW R G Q G L+L ++ D+GDY C A G+
Sbjct: 2330 KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNA-----AGSTSVAFR 2384
Query: 395 VNAPPVVTALHSAPAF---LRGPARLQCLVFASPAPDAVVWSWD 435
V V T PA + A L C PAP V W D
Sbjct: 2385 VEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAP-LVSWRKD 2427
Score = 85.5 bits (210), Expect = 2e-16
Identities = 105/389 (26%), Positives = 153/389 (39%), Gaps = 56/389 (14%)
Query: 32 DLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHI 90
DL G A LPC A G+ + W K G + G ++ I + +L +
Sbjct: 2764 DLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAE-----GKFTIQPSG-----ELLV 2813
Query: 91 RPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSR 149
+ +E +D +Y C A A G R L +LV P + G S+ L G L C +R
Sbjct: 2814 KNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRL--GDRLWLRCAAR 2871
Query: 150 GDARPTPELLWFRDGVLLDGATFHQTLLKEG-TPGSVESTLTLTPFSHDDGATFVCRARS 208
G PTP + W T + + EG + STL S +D T+VC A +
Sbjct: 2872 GS--PTPRIGW----------TVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAEN 2919
Query: 209 QALPTGRDTAIT-LSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSP 267
+ GR A++ + ++ P + A + V+ I L PV W K G P
Sbjct: 2920 RV---GRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 2976
Query: 268 VLGARGPRLEVVADASFLT---------EPVSCEVSNAVGSANRSTALDVLFGPILQAKP 318
+ RG L LT C N +G A + L + P+ Q +P
Sbjct: 2977 L---RGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEP 3033
Query: 319 EPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLR--------LPSVGPEDA 370
+ ++V G+D + C G P P + W + G Q L + LR L +V DA
Sbjct: 3034 QDMTVRSGDDVALRCQATGEPTPTIEWLQAG--QPLRASRRLRTLPDGSLWLENVETGDA 3091
Query: 371 GDYVCRAEAGLSGLRGGAAEARLTVNAPP 399
G Y C A + L A A L V P
Sbjct: 3092 GTYDCVAH---NLLGSATARAFLVVRGEP 3117
Score = 78.2 bits (191), Expect = 2e-14
Identities = 100/372 (26%), Positives = 144/372 (38%), Gaps = 54/372 (14%)
Query: 88 LHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 146
L ++ + D Y C A A G S ++ + P G P+V++ A L C
Sbjct: 2355 LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS--GPPAVNVSVNQTALLPC 2412
Query: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 206
++ D P P + W +D V LD + +L EG+ L + P D ++C A
Sbjct: 2413 QA--DGVPAPLVSWRKDRVPLDPRSPRFEILPEGS-------LRIQPVLAQDAGHYLCLA 2463
Query: 207 RSQALPT--GRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKG 264
+ A GRD L + PP + S S T+ + C+A+ P W G
Sbjct: 2464 SNSAGSDRQGRD----LRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDG 2519
Query: 265 GSPVLGAR-GPRLEVVADASFLTEP-------VSCEVSNAVGSANRSTALDVLFGPILQA 316
+ G + ++A LT P C VSN VG A+R + V P +
Sbjct: 2520 QKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIAD 2579
Query: 317 KPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG--------GAQVLGSGATLRLPSVGPE 368
+V + +C G P P V+W++ G G +V SGA L + P
Sbjct: 2580 DQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGA-LEIGQALPI 2638
Query: 369 DAGDYVCRAEAGLSGLRGGAAEAR----LTVNAPPVVTALHSAPAFLRGPAR----LQCL 420
AG Y C A R A A LTV A PVV L P+ +R A L C
Sbjct: 2639 HAGRYTCSA-------RNSAGVAHKHVFLTVQASPVVKPL---PSVVRAVAEEEVLLPCE 2688
Query: 421 VFASPAPDAVVW 432
P P + W
Sbjct: 2689 ASGIPRP-TITW 2699
Score = 71.6 bits (174), Expect = 2e-12
Identities = 111/474 (23%), Positives = 174/474 (36%), Gaps = 89/474 (18%)
Query: 70 PGWSRYWISGNAANGQHDLHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQV 128
PG Y ++G L + + +D Y C A+ +AG R + VLVPP
Sbjct: 1113 PGEDTYLLAGGWM-----LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENE 1167
Query: 129 LGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVEST 188
+ ++ G A+L C G P P+L WF+DG L H +P V
Sbjct: 1168 DLEEVIKVLDGQTAHLMCNVTG--HPQPKLTWFKDGRPLARGDAHHI-----SPDGV--L 1218
Query: 189 LTLTPFSHDDGATFVCRARSQALPTGRDTA-ITLSLQYPPEVTLSASPH-----TVQEGE 242
L + + + C A A G T LS+ P + A TV
Sbjct: 1219 LQVLQANLSSAGHYSCIA---ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNN 1275
Query: 243 KVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRL-------EVVADASFLTEPVSCEVSN 295
+ +C+A A P W K G+P +R +L +++ +C V+N
Sbjct: 1276 PISLICEALAFPS-PNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTN 1334
Query: 296 AVGSANRSTALDVLFGPILQAKPEP--------VSVDVGEDASFSCAWRGNPLPRVTWTR 347
+G A ++ ++VL P + +K +P V V + C P P + W +
Sbjct: 1335 ELGEAVKNYHVEVLIPPSI-SKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYK 1393
Query: 348 RGGA-------QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPV 400
G QVLG G L++ D+G Y+C A ++G + + + PP+
Sbjct: 1394 DGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVA-TNVAG--EDDQDFNVLIQVPPM 1450
Query: 401 VTALHSAPAFL---------------------RGPARLQCLVFASPAPDAVVWSWDEGFL 439
+ A PA L C A P PD + W ++ L
Sbjct: 1451 FQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPD-LTWYREDQPL 1509
Query: 440 EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGE 493
AG + L +GG VL I + + R ++C A N +GE
Sbjct: 1510 SAGDEVSVL---------QGG------RVLQIPLVRAENAGR-YSCKASNEVGE 1547
Score = 69.7 bits (169), Expect = 9e-12
Identities = 119/458 (25%), Positives = 163/458 (35%), Gaps = 93/458 (20%)
Query: 88 LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPP----------------EAPQVLG 130
L I+P ++ D Y C AT AG + + + VPP + G
Sbjct: 1413 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARG 1472
Query: 131 GPSV--SLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVEST 188
G + +V PA L C + +A P P+L W+R+ L A ++L+ G
Sbjct: 1473 GVTEYREIVENNPAYLYCDT--NAIPPPDLTWYREDQPL-SAGDEVSVLQGG------RV 1523
Query: 189 LTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE-----GEK 243
L + ++ + C+A ++ G D L P V L + V+E
Sbjct: 1524 LQIPLVRAENAGRYSCKASNE---VGEDWLHYELLVLTPPVILGDTEELVEEVTVNASST 1580
Query: 244 VIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS---------CEVS 294
V C A PV W + G P + PRL+V+ D L + C
Sbjct: 1581 VSLQCPALGN-PVPTISWLQNGLPF--SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAE 1637
Query: 295 NAVGSANRSTALDVLFGP-ILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQV 353
N GSA + L V P I E V+ + S C +P P VTW + A
Sbjct: 1638 NQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALS 1697
Query: 354 LGSGA-------TLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHS 406
LG TL+L D+G Y C A L+ +L+V PP A
Sbjct: 1698 LGEEVFLLPGTHTLQLGRARLSDSGMYTCEA---LNAAGRDQKLVQLSVLVPP---AFRQ 1751
Query: 407 APAFLRGP-----------ARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAP 455
AP RGP A L C A P P V W D G+ LV
Sbjct: 1752 AP---RGPQDAVLVRVGDKAVLSCETDALPEP-TVTWYKD---------GQPLVLAQRTQ 1798
Query: 456 ESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGE 493
RGG L I Q SD ++C N GE
Sbjct: 1799 ALRGG------QRLEIQEAQVSD-KGLYSCKVSNVAGE 1829
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/142 (26%), Positives = 52/142 (36%), Gaps = 33/142 (23%)
Query: 321 VSVDVGEDASFSCAWRGNPLPRVTWTRR----------------------GGAQVLGSGA 358
VS G+ + C G P+P + W + GG ++L G
Sbjct: 28 VSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQ 87
Query: 359 TLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEA--RLTVNAPPVVTALHSAPAFL---RG 413
+L P + D+G Y CRAE + G A+ L V PP V +A L
Sbjct: 88 SLHFPRIQEGDSGLYSCRAEN-----QAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGA 142
Query: 414 PARLQCLVFASPAPDAVVWSWD 435
LQC P P V W+ D
Sbjct: 143 DVELQCWTSGVPTPQ-VEWTKD 163
Score = 32.7 bits (73), Expect = 1.2
Identities = 33/118 (27%), Positives = 52/118 (44%), Gaps = 14/118 (11%)
Query: 23 SPHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNA 81
+P F +P+D+ V G++ L C A G ++W ++G L R L R G+
Sbjct: 3026 APVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRL----RTLPDGS- 3080
Query: 82 ANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAG 139
L + VE D +Y+C A L S A+ ++V E PQ G ++ G
Sbjct: 3081 ------LWLENVETGDAGTYDCVAHNL-LGSATARAFLVVRGE-PQGSWGSMTGVING 3130
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 107 bits (268), Expect = 3e-23
Identities = 138/514 (26%), Positives = 198/514 (38%), Gaps = 79/514 (15%)
Query: 19 RAGPS---PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSR 74
R GP P ++QP DL+V GE A LPC A G ++W K+G + R+ P R
Sbjct: 56 RVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHR 115
Query: 75 YWISGNAANGQHDLHIRPVELEDEASYECQATQ--AGLRSRPAQLHVLVPPEAPQVLGGP 132
+ A +H R DE Y C A SR A L V V + + G
Sbjct: 116 LLLPSGALFFPRIVHGRRAR-PDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPG- 173
Query: 133 SVSLVAGVPANLTC-RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTL 191
+V + G PA L C RG P P + W +DG L +EG L +
Sbjct: 174 NVVVAVGEPAVLECVPPRG--HPEPSVSWRKDGARLKE--------EEGRITIRGGKLMM 223
Query: 192 TPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQAT 251
+ D +VC A + A A + L+ P + + V V FLC+
Sbjct: 224 SHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVN-QVVLADAPVTFLCEVK 282
Query: 252 AQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRS 303
PP RW K + R E+ +D S VS C N+VG A S
Sbjct: 283 GDPPPR-LRWRKEDGELPTGR---YEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEAS 338
Query: 304 TALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLR-- 361
+L V P L +P+ GE +F C +GNP P + W + G +L +L+
Sbjct: 339 GSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPT 398
Query: 362 ------------LPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPA 409
+ +V DAG YVC+A + + A+A L + + P
Sbjct: 399 GRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSI---LAKALLEIKGASLDGL---PPV 452
Query: 410 FLRGPAR----------LQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRG 459
L+GPA L C V +P P +V W D +L+ G +F
Sbjct: 453 ILQGPANQTLVLGSSVWLPCRVTGNPQP-SVRWKKDGQWLQ-GDDLQFKTMA-------- 502
Query: 460 GLGPGLISVLHISGTQESDFSRSFNCSARNRLGE 493
L+I+ QE D ++C A++ GE
Sbjct: 503 ------NGTLYIANVQEMDMG-FYSCVAKSSTGE 529
Score = 32.3 bits (72), Expect = 1.6
Identities = 40/159 (25%), Positives = 55/159 (34%), Gaps = 33/159 (20%)
Query: 553 PGSSDGSSSRGPEEEETGSRE---------DRGPIVHTDHSDLVLEEKGTLETKDPTNGY 603
P S + S GPEEE GS E +R + S L ET PT Y
Sbjct: 1089 PPSCELSCLEGPEEELEGSSEPEEWCPPMPERSHLTEPSSSGGCLVTPSRRETPSPTPSY 1148
Query: 604 YKVRGVSVSLSLGEAPGGGLFLPPPSPLGPPGTPTFYDFNPHLGMVPPCRLYRARAGYLT 663
+ +++ PSP PP PT PHL +P R+ + L+
Sbjct: 1149 GQQSTATLT---------------PSPPDPPQPPTDM---PHLHQMPR-RVPLGPSSPLS 1189
Query: 664 TPHPRAFTSYIKPTSFG-----PPDLAPGTPPFPYAAFP 697
P +P G P L+P P ++ P
Sbjct: 1190 VSQPMLGIREARPAGLGAGPAASPHLSPSPAPSTASSAP 1228
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 107 bits (266), Expect = 5e-23
Identities = 133/490 (27%), Positives = 188/490 (38%), Gaps = 72/490 (14%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P D V + L C + G V W+K+G LG + S Y +S + A
Sbjct: 2666 PTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARG-----SGYRVSPSGA 2720
Query: 83 NGQHDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEA-PQVLGGPSV-SLVAG 139
L I Y C A AG+ A HV + +A P V PSV VA
Sbjct: 2721 -----LEIGQALPIHAGRYTCSARNSAGV----AHKHVFLTVQASPVVKPLPSVVRAVAE 2771
Query: 140 VPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDG 199
L C + G RPT + W ++G+ + Q L PG L + S +D
Sbjct: 2772 EEVLLPCEASGIPRPT--ITWQKEGLNVATGVSTQVL-----PGG---QLRIAHASPEDA 2821
Query: 200 ATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGY 259
++C A++ A T + + Q PP + + EG C+A P
Sbjct: 2822 GNYLCIAKNSAGSAMGKTRLVV--QVPPVIENGLPDLSTTEGSHAFLPCKARGSPE-PNI 2878
Query: 260 RWAKGGSPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFG 311
W K G PV GA G + + L + + +C NAVG A R L +L
Sbjct: 2879 TWDKDGQPVSGAEG-KFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL 2937
Query: 312 PILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-----GAQVLGSGATLRLPSVG 366
P+ P S+ +G+ CA RG+P PR+ WT G G+TL+ +V
Sbjct: 2938 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVS 2997
Query: 367 PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFL----RGPARLQCLVF 422
ED+G YVC AE R G +A V+ A ++L G +L C+V
Sbjct: 2998 REDSGTYVCWAEN-----RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVR 3052
Query: 423 ASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRS 482
P PD + W D G GS R ++ L I T+ D R
Sbjct: 3053 GDPVPD-IHWIKD-GLPLRGSHLRHQLQN---------------GSLTIHRTERDDAGR- 3094
Query: 483 FNCSARNRLG 492
+ C A N +G
Sbjct: 3095 YQCLAENEMG 3104
Score = 102 bits (254), Expect = 1e-21
Identities = 120/446 (26%), Positives = 167/446 (37%), Gaps = 70/446 (15%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P+ P + VL L C A G V W K G + + W +S +
Sbjct: 695 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFK------GHQPVSSWMGVTVSVDG- 747
Query: 83 NGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEA--PQVLGGPSVSLVAG 139
L I +L D SY C A+ AG L V VPP P L GP ++
Sbjct: 748 ---RVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGP---VLVN 801
Query: 140 VPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVE----STLTLTPFS 195
P LTC + G P+P L+W +DG + A GTPG LTL
Sbjct: 802 TPVRLTCNATG--APSPTLMWLKDGNPVSPA---------GTPGLQVFPGGRVLTLASAR 850
Query: 196 HDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPP 255
D + C A S +D + L + PP + +V E V CQ+ A PP
Sbjct: 851 ASDSGRYSCVAVSAVGEDRQD--VVLQVHMPPSILGEELNVSVVANESVALECQSHAMPP 908
Query: 256 VTGYRWAKGGSPVLGARGPRLEV-----------VADASFLTEPVSCEVSNAVGSANRST 304
W K G P+ G L V DA T CE N G + +
Sbjct: 909 PV-LSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYT----CEALNQAGRSEKHY 963
Query: 305 ALDVLFGPILQAKPE-PVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLR-L 362
L+V P+ + ++V G S SC RG P P+++W R+ G + G GA L+ +
Sbjct: 964 NLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISW-RKDGQPLPGEGAGLQHV 1022
Query: 363 PSVGP---------EDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR- 412
+VG G Y C + + + + +L V+ PP + P +
Sbjct: 1023 SAVGRLLYLGQAQLAQEGTYTCECS---NVVGNSSQDLQLEVHVPPQIAGPREPPTQVSV 1079
Query: 413 ---GPARLQCLVFASPAPDAVVWSWD 435
G A L+C P P V W D
Sbjct: 1080 VQDGVATLECNATGKP-PPTVTWERD 1104
Score = 101 bits (252), Expect = 2e-21
Identities = 128/483 (26%), Positives = 182/483 (37%), Gaps = 74/483 (15%)
Query: 32 DLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHI 90
D+VV+ G LPC A G LV W K G L Q G S L +
Sbjct: 2224 DVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPS--------------LQL 2269
Query: 91 RPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSR 149
V D +Y C A ++AG R QL V+ PP +SL G P L C ++
Sbjct: 2270 EAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 2329
Query: 150 GDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQ 209
G P P + W +DG Q L + L + D + C A S
Sbjct: 2330 GT--PQPNITWHKDG---------QALTRLENNSRATRVLRVR-----DAGLYTCLAES- 2372
Query: 210 ALPTGR-DTAITLSLQYPPEVTLSASPHTVQ--EGEKVIFLCQATAQPPVTGYRWAKGGS 266
P G + + + +Q PP + P V +++ C A+P W + G
Sbjct: 2373 --PAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEP-APKITWHRDGI 2429
Query: 267 PV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPE 319
+ RG L++ A ++ + SC NA GS + + +++ P +++ P
Sbjct: 2430 VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPP 2489
Query: 320 PVSVDVGEDASFSCAWRGNPLPRVTW--------TRRGGAQVLGSGATLRLPSVGPEDAG 371
V+V V + A C G P P V+W R ++L G +LR+ V +DAG
Sbjct: 2490 AVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG-SLRIQPVLAQDAG 2548
Query: 372 DYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHS-APAFLRGPARLQCLVFASPAPDAV 430
Y+C A R G L V PP + S PA L C SP P V
Sbjct: 2549 HYLCLASNSAGSDRQG---RDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKP-LV 2604
Query: 431 VWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNR 490
VW W +G F + L P +L G Q+ S F C N
Sbjct: 2605 VW-WKDG----------QKLDFRLQQGAYRLLPSNALLLTAPGPQD---SAQFECVVSNE 2650
Query: 491 LGE 493
+GE
Sbjct: 2651 VGE 2653
Score = 99.4 bits (246), Expect = 1e-20
Identities = 116/418 (27%), Positives = 159/418 (38%), Gaps = 57/418 (13%)
Query: 108 AGLRSRPAQLHVLVPPEAPQVLGGPSVSLV---AGVPANLTCRSRGDARPTPELLWFRDG 164
AG P H PP P VLG + V AG L C + G PTP++ W +D
Sbjct: 199 AGFEQFPTP-HAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGV--PTPQVEWTKDR 255
Query: 165 VLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQ 224
+ H + ++G L +T D + C A S A RD L +
Sbjct: 256 QPVLPGGPHLQVQEDG------QVLRITGSHVGDEGRYQCVAFSPAGQQARD--FQLRVH 307
Query: 225 YPPEVTLS--ASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGS------PVLGARGPR- 275
PP + S V E V LC+A P W K G+ V+ RG R
Sbjct: 308 APPTIWGSNETGEVAVMEDHLVQLLCEARGVP-TPNITWFKDGALLPTSTKVVYTRGGRQ 366
Query: 276 LEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQ---AKPEPVSVDVGEDASFS 332
L++ S +C+ SNAVG+A ++T LDV P ++ +P V G +
Sbjct: 367 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALE 426
Query: 333 CAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLR 385
C RG+P P ++W G +++ G+ LRL S G +G Y C A S
Sbjct: 427 CVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVAS---SPAG 483
Query: 386 GGAAEARLTVNAPP---VVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAG 442
+ + V PP V L + P L C SP P + W L+ G
Sbjct: 484 EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVP-TIQW------LQNG 536
Query: 443 SQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASL 500
PA E G + LHI E D S F C A N G GA+ +
Sbjct: 537 R---------PAEELAGVQVASQGTTLHIDHV-ELDHSGLFACQATNEAGTAGAEVEV 584
Score = 99.0 bits (245), Expect = 1e-20
Identities = 137/491 (27%), Positives = 186/491 (37%), Gaps = 73/491 (14%)
Query: 31 EDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLH 89
E++ V L C ALG + W ++GL L L
Sbjct: 1662 EEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRL----------QVLEDGQVLQ 1711
Query: 90 IRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRS 148
+ E+ D ASY C A QAG + L V VPP L V+ + +L C
Sbjct: 1712 VSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAG-LDLEQVTAILNSSVSLPCDV 1770
Query: 149 RGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARS 208
A P PE+ W++D L + + L GT TL L D + C A +
Sbjct: 1771 H--AHPNPEVTWYKDSQAL--SLGEEVFLLPGT-----HTLQLGRARLSDSGMYTCEALN 1821
Query: 209 QALPTGRD-TAITLSLQYPPEVTLSASPHTVQE------GEKVIFLCQATAQPPVTGYRW 261
A GRD + LS+ PP +P Q+ G+K + C+ A P T W
Sbjct: 1822 AA---GRDQKLVQLSVLVPP--AFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-VTW 1875
Query: 262 AKGGSPVLGAR-------GPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPIL 314
K G P++ A+ G RLE+ SC+VSN G A R+ L V P
Sbjct: 1876 YKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTF 1935
Query: 315 Q-AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTR-------RGGAQVLGSGATLRLPSVG 366
+ K E VS G +C G P P VTW + V+ G L+L +
Sbjct: 1936 ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQ 1995
Query: 367 PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPV-VTALHSAPAFLRG-PARLQCLVFAS 424
P AG Y C AE + R A L AP + + + L G RL C
Sbjct: 1996 PAQAGTYTCVAENTQAEARKDFVVAVLV--APRIRSSGVAREHHVLEGQEVRLDCEADGQ 2053
Query: 425 PAPDAVVWSWDEGFL--EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRS 482
P PD V W D L + G RF ++ GG L + G + SD + +
Sbjct: 2054 PPPD-VAWLKDGSPLGQDMGPHLRFYLD--------GG-------SLVLKGLRASD-AGA 2096
Query: 483 FNCSARNRLGE 493
+ C A N GE
Sbjct: 2097 YTCVAHNPAGE 2107
Score = 95.5 bits (236), Expect = 1e-19
Identities = 132/499 (26%), Positives = 203/499 (40%), Gaps = 84/499 (16%)
Query: 80 NAANGQHDLHIRPVELEDEAS---YECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVS 135
N + + D + +E EAS Y C A+ AG + V VPP+ G V+
Sbjct: 450 NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVT 509
Query: 136 LVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFS 195
+ G P L C++ G P P + W ++G + Q + +GT TL +
Sbjct: 510 TIVGQPLELPCQASGS--PVPTIQWLQNGRPAEELAGVQ-VASQGT------TLHIDHVE 560
Query: 196 HDDGATFVCRARSQALPTGRDTAITLSLQYPP---EVTLSASPHTVQEGEKVIFLCQ--- 249
D F C+A ++A G + +++ ++ P EV + + C
Sbjct: 561 LDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPV 620
Query: 250 -----ATAQPPVT------GYRWAKG-GSPVLGARGPRLEV----VADASFLTEPVSCEV 293
A +PP+ G W + G PV + P L++ + D T C
Sbjct: 621 HRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYT----CAA 676
Query: 294 SNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDAS--FSCAWRGNPLPRVTWTRRG-- 349
+N G + R AL VL P ++ P PV+ V E+AS C G P P V+W +
Sbjct: 677 TNLAGESKREVALKVLVPPNIE--PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQP 734
Query: 350 -----GAQVLGSGATLRLPSVGPEDAGDYVCRAE--AGLSGLRGGAAEARLTVNAPPVVT 402
G V G LR+ DAG Y C A AG + LR G L VN PP +T
Sbjct: 735 VSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-----LRVNVPPRIT 789
Query: 403 ALHS--APAFLRGPARLQCLVFASPAPDAVVWSWDEGFLE-AGSQGRFLVETFPAPESRG 459
S P + P RL C +P+P ++W D + AG+ G ++ FP G
Sbjct: 790 LPPSLPGPVLVNTPVRLTCNATGAPSP-TLMWLKDGNPVSPAGTPG---LQVFP-----G 840
Query: 460 GLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAAT 519
G VL ++ + SD R ++C A + +GE R+D++ V + +
Sbjct: 841 G------RVLTLASARASDSGR-YSCVAVSAVGE-------DRQDVVLQVHMPPSILGEE 886
Query: 520 TTLLMVIT-GVALCCWRHS 537
+ +V VAL C H+
Sbjct: 887 LNVSVVANESVALECQSHA 905
Score = 95.1 bits (235), Expect = 2e-19
Identities = 129/507 (25%), Positives = 190/507 (37%), Gaps = 92/507 (18%)
Query: 27 LQQPEDLVVLLGEEARLPCAL-GAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQ 85
L++ L V G L C G + + W K G L G+ G G
Sbjct: 975 LRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEG--AGLQHVSAVGRL---- 1028
Query: 86 HDLHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPS-VSLVAGVPAN 143
L++ +L E +Y C+ + G S+ QL V VPP+ P+ VS+V A
Sbjct: 1029 --LYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVAT 1086
Query: 144 LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 203
L C + G +P P + W RDG + GA L +G VE
Sbjct: 1087 LECNATG--KPPPTVTWERDGQPV-GAELGLQLQNQGQSLHVE----------------- 1126
Query: 204 CRARSQALPTGRDTAIT------------LSLQYPPEVTLSASPHT---VQEGEKVIFLC 248
R+QA TGR + + LS+ PPE+ P T + LC
Sbjct: 1127 ---RAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLC 1183
Query: 249 QATAQPPVTGYRWAKGGSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSAN 301
+A PP RW +G PV L A G L++ + SC SN G A
Sbjct: 1184 EAMGIPP-PAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEAR 1242
Query: 302 RSTALDVLFGPILQAKP--EPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLG---- 355
R+ +++VL P ++ + E + V G+ A C G+P P++TW + G G
Sbjct: 1243 RNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHH 1302
Query: 356 ---SGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV------TALHS 406
G L++ AG Y C A + + +L+V P + +A
Sbjct: 1303 ISPDGVLLQVLQANLSSAGHYSCIA---ANAVGEKTKHFQLSVLLAPTILGGAEDSADEE 1359
Query: 407 APAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLI 466
+ P L C A P+P+ + W D EA + L P + G
Sbjct: 1360 VTVTVNNPISLICEALAFPSPN-ITWMKDGAPFEASRNIQLL------PGTHG------- 1405
Query: 467 SVLHISGTQESDFSRSFNCSARNRLGE 493
L I Q+ D + + C N LGE
Sbjct: 1406 --LQILNAQKED-AGQYTCVVTNELGE 1429
Score = 94.0 bits (232), Expect = 4e-19
Identities = 145/532 (27%), Positives = 201/532 (37%), Gaps = 87/532 (16%)
Query: 35 VLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPV 93
VL+ RL C A GA + W K G + PG + G L +
Sbjct: 798 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVS-PAGTPGLQVF-------PGGRVLTLASA 849
Query: 94 ELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGP-SVSLVAGVPANLTCRSRGD 151
D Y C A A G + L V +PP +LG +VS+VA L C+S
Sbjct: 850 RASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS---ILGEELNVSVVANESVALECQSH-- 904
Query: 152 ARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHD-DGATFVCRARSQA 210
A P P L W++DG L+ + G S + L + D + C A +QA
Sbjct: 905 AMPPPVLSWWKDGRPLEP--------RPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 956
Query: 211 LPTGR-DTAITLSLQYPPEVTLSASPH-TVQEGEKVIFLCQATAQPPVTGYRWAKGGSPV 268
GR + L++ P L S TV+EG C+ P W K G P+
Sbjct: 957 ---GRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVP-FPKISWRKDGQPL 1012
Query: 269 LGARGP--------RLEVVADASFLTEPV-SCEVSNAVGSANRSTALDVLFGPILQAKPE 319
G RL + A E +CE SN VG++++ L+V P + E
Sbjct: 1013 PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPRE 1072
Query: 320 P-VSVDVGED--ASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVGPED 369
P V V +D A+ C G P P VTW R G G Q+ G +L +
Sbjct: 1073 PPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAH 1132
Query: 370 AGDYVCRAEAGLSGLRGGA-AEARLTVNAPPVVTA----LHSAPAFLRGPARLQCLVFAS 424
G Y C AE L G A + L+V PP + L + A L P L C
Sbjct: 1133 TGRYSCVAE----NLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGI 1188
Query: 425 PAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFN 484
P P A+ W E + G L GG +L ++ TQE D S ++
Sbjct: 1189 P-PPAIRWFRGEEPVSPGEDTYLLA---------GGW------MLKMTQTQEQD-SGLYS 1231
Query: 485 CSARNRLGEGG--------AQASLGRRDLLPTVRIVAGVAAATTTLLMVITG 528
C A N GE S+ DL ++++ G T L+ +TG
Sbjct: 1232 CLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDG---QTAHLMCNVTG 1280
Score = 90.1 bits (222), Expect = 6e-18
Identities = 130/490 (26%), Positives = 178/490 (36%), Gaps = 77/490 (15%)
Query: 79 GNAANGQHDLHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQVLGGPSVSLV 137
G A + L + V D YECQAT + G SR A+L V VPP + +VS +
Sbjct: 50 GVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGM 109
Query: 138 AGVPANLTCRSRGDARPTPELLWFRDGVLLD--------------GATFHQTLLKEGTPG 183
AG L C + G P PE++W +D L+ G LL EG
Sbjct: 110 AGQSLTLECDANG--FPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQ-- 165
Query: 184 SVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEG-- 241
S+ S GA A+++A P A P + A P + G
Sbjct: 166 SLHFPRIQPGRSGRRGAQAGGSAQTKA-PWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAA 224
Query: 242 EKVIFLCQA-------TAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS---- 290
++V+ L A T+ P W K PVL GP L+V D L S
Sbjct: 225 QEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG-GPHLQVQEDGQVLRITGSHVGD 283
Query: 291 -----CEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGED--ASFSCAWRGNPLPRV 343
C + G R L V P + E V V ED C RG P P +
Sbjct: 284 EGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNI 343
Query: 344 TWTRRGGAQVLGS-------GATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAE--ARLT 394
TW + G + G L+L DAG Y C+A + GAAE RL
Sbjct: 344 TWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAV-----GAAEKATRLD 398
Query: 395 VNAPPVVTALHSAPAFLRG----PARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVE 450
V PP + P ++ P L+C+ P+P SW L +E
Sbjct: 399 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP---TLSWHHEGLPVAESNESRLE 455
Query: 451 TFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVR 510
T SVL + E+ S ++C A + GE Q S+ + P +
Sbjct: 456 TDG-------------SVLRLESPGEAS-SGLYSCVASSPAGEAVLQYSV-EVQVPPQLL 500
Query: 511 IVAGVAAATT 520
+ G+ TT
Sbjct: 501 VAEGLGQVTT 510
Score = 88.6 bits (218), Expect = 2e-17
Identities = 105/372 (28%), Positives = 139/372 (37%), Gaps = 46/372 (12%)
Query: 88 LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 146
L I V+L DE Y C AT AG R L VLVPP G + +++ L C
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP--GPVNKAVLENASVTLEC 716
Query: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLK-EGTPGSVES-TLTLTPFSHDDGATFVC 204
+ G P P++ WF+ HQ + G SV+ L + D ++ C
Sbjct: 717 LASGV--PPPDVSWFKG---------HQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRC 765
Query: 205 RARSQALPTGRDTAITLSLQYPPEVTLSAS-PHTVQEGEKVIFLCQATAQPPVTGYRWAK 263
A + A T + L + PP +TL S P V V C AT P T W K
Sbjct: 766 VASNVAGST--ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT-LMWLK 822
Query: 264 GGSPVLGARGPRLEVVADASFLTEP---------VSCEVSNAVGSANRSTALDVLFGPIL 314
G+PV A P L+V LT SC +AVG + L V P +
Sbjct: 823 DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI 882
Query: 315 QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVGP 367
+ VSV E + C P P ++W + G G + A L++
Sbjct: 883 LGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADV 942
Query: 368 EDAGDYVCRA--EAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR--GPARLQCLVFA 423
DAG Y C A +AG S L V PV S +R P L C
Sbjct: 943 WDAGHYTCEALNQAGRS-----EKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRG 997
Query: 424 SPAPDAVVWSWD 435
P P + W D
Sbjct: 998 VPFP-KISWRKD 1008
Score = 87.4 bits (215), Expect = 4e-17
Identities = 125/490 (25%), Positives = 180/490 (36%), Gaps = 71/490 (14%)
Query: 31 EDLVVLLGEEARLPCALGAYWGL-VQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLH 89
E + +L LPC + A+ V W K AL ++ G H L
Sbjct: 1754 EQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEV----------FLLPGTHTLQ 1803
Query: 90 IRPVELEDEASYECQATQAGLRSRP-AQLHVLVPPEAPQVLGGP--SVSLVAGVPANLTC 146
+ L D Y C+A A R + QL VLVPP Q GP +V + G A L+C
Sbjct: 1804 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSC 1863
Query: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 206
+ DA P P + W++DG L A Q L+ G L + D + C+
Sbjct: 1864 ET--DALPEPTVTWYKDGQPLVLAQRTQA-LRGG------QRLEIQEAQVSDKGLYSCKV 1914
Query: 207 RSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE--GEKVIFLCQATAQPPVTGYRWAKG 264
+ A R TL++Q PP + TV + G ++ C + P T W K
Sbjct: 1915 SNVAGEAVR--TFTLTVQVPPTFE-NPKTETVSQVAGSPLVLTCDVSGVPAPT-VTWLKD 1970
Query: 265 GSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAK 317
PV + +RG RL++ +C N A + + VL P +++
Sbjct: 1971 RMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSS 2030
Query: 318 --PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG--AQVLG-------SGATLRLPSVG 366
V G++ C G P P V W + G Q +G G +L L +
Sbjct: 2031 GVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLR 2090
Query: 367 PEDAGDYVCRAEAGLSGLRGGAAEARL-TVNA---PPVVTALHSAPAFLRGPARLQCLVF 422
DAG Y C A +ARL TVN P + + + P L +V
Sbjct: 2091 ASDAGAYTCVAH------NPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC 2144
Query: 423 ASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRS 482
+ SW L + P P S+ L G L IS Q +D +
Sbjct: 2145 PVRGSPPIHVSW-------------LKDGLPLPLSQRTLLHGSGHTLRISKVQLAD-AGI 2190
Query: 483 FNCSARNRLG 492
F C A + G
Sbjct: 2191 FTCVAASPAG 2200
Score = 87.4 bits (215), Expect = 4e-17
Identities = 111/404 (27%), Positives = 151/404 (37%), Gaps = 61/404 (15%)
Query: 54 VQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYEC-QATQAGLRS 112
V W K GL L P R + G+ H L I V+L D + C A+ AG+
Sbjct: 2154 VSWLKDGLPL------PLSQRTLLHGSG----HTLRISKVQLADAGIFTCVAASPAGVAD 2203
Query: 113 RPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATF 172
R L V VPP V V +V G L C +RG P P + W +DG L +
Sbjct: 2204 RNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARG--VPLPLVSWMKDGEPLLSQSL 2261
Query: 173 HQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLS 232
Q +L L D T+ C A S+A R L++ PP + S
Sbjct: 2262 EQ-----------GPSLQLEAVGAGDSGTYSCVAVSEAGEARRH--FQLTVMEPPHIEDS 2308
Query: 233 ASPH--TVQEGEKVIFLC--QATAQPPVTGYRWAKGGSPVL----GARGPRLEVVADASF 284
P ++ G + LC Q T QP +T W K G + +R R+ V DA
Sbjct: 2309 GQPTELSLTPGAPMELLCDAQGTPQPNIT---WHKDGQALTRLENNSRATRVLRVRDAGL 2365
Query: 285 LTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEP---VSVDVGEDASFSCAWRGNPLP 341
T C + G+ +S + V P + P V + G+ C+ P P
Sbjct: 2366 YT----CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQ-LVLECSVEAEPAP 2420
Query: 342 RVTWTRRG-------GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLT 394
++TW R G Q G L+L ++ D+GDY C A G+
Sbjct: 2421 KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNA-----AGSTSVAFR 2475
Query: 395 VNAPPVVTALHSAPAF---LRGPARLQCLVFASPAPDAVVWSWD 435
V V T PA + A L C PAP V W D
Sbjct: 2476 VEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAP-LVSWRKD 2518
Score = 85.5 bits (210), Expect = 2e-16
Identities = 105/389 (26%), Positives = 153/389 (39%), Gaps = 56/389 (14%)
Query: 32 DLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHI 90
DL G A LPC A G+ + W K G + G ++ I + +L +
Sbjct: 2855 DLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAE-----GKFTIQPSG-----ELLV 2904
Query: 91 RPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSR 149
+ +E +D +Y C A A G R L +LV P + G S+ L G L C +R
Sbjct: 2905 KNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRL--GDRLWLRCAAR 2962
Query: 150 GDARPTPELLWFRDGVLLDGATFHQTLLKEG-TPGSVESTLTLTPFSHDDGATFVCRARS 208
G PTP + W T + + EG + STL S +D T+VC A +
Sbjct: 2963 GS--PTPRIGW----------TVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAEN 3010
Query: 209 QALPTGRDTAIT-LSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSP 267
+ GR A++ + ++ P + A + V+ I L PV W K G P
Sbjct: 3011 RV---GRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 3067
Query: 268 VLGARGPRLEVVADASFLT---------EPVSCEVSNAVGSANRSTALDVLFGPILQAKP 318
+ RG L LT C N +G A + L + P+ Q +P
Sbjct: 3068 L---RGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEP 3124
Query: 319 EPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLR--------LPSVGPEDA 370
+ ++V G+D + C G P P + W + G Q L + LR L +V DA
Sbjct: 3125 QDMTVRSGDDVALRCQATGEPTPTIEWLQAG--QPLRASRRLRTLPDGSLWLENVETGDA 3182
Query: 371 GDYVCRAEAGLSGLRGGAAEARLTVNAPP 399
G Y C A + L A A L V P
Sbjct: 3183 GTYDCVAH---NLLGSATARAFLVVRGEP 3208
Score = 78.2 bits (191), Expect = 2e-14
Identities = 100/372 (26%), Positives = 144/372 (38%), Gaps = 54/372 (14%)
Query: 88 LHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 146
L ++ + D Y C A A G S ++ + P G P+V++ A L C
Sbjct: 2446 LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS--GPPAVNVSVNQTALLPC 2503
Query: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 206
++ D P P + W +D V LD + +L EG+ L + P D ++C A
Sbjct: 2504 QA--DGVPAPLVSWRKDRVPLDPRSPRFEILPEGS-------LRIQPVLAQDAGHYLCLA 2554
Query: 207 RSQALPT--GRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKG 264
+ A GRD L + PP + S S T+ + C+A+ P W G
Sbjct: 2555 SNSAGSDRQGRD----LRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDG 2610
Query: 265 GSPVLGAR-GPRLEVVADASFLTEP-------VSCEVSNAVGSANRSTALDVLFGPILQA 316
+ G + ++A LT P C VSN VG A+R + V P +
Sbjct: 2611 QKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIAD 2670
Query: 317 KPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG--------GAQVLGSGATLRLPSVGPE 368
+V + +C G P P V+W++ G G +V SGA L + P
Sbjct: 2671 DQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGA-LEIGQALPI 2729
Query: 369 DAGDYVCRAEAGLSGLRGGAAEAR----LTVNAPPVVTALHSAPAFLRGPAR----LQCL 420
AG Y C A R A A LTV A PVV L P+ +R A L C
Sbjct: 2730 HAGRYTCSA-------RNSAGVAHKHVFLTVQASPVVKPL---PSVVRAVAEEEVLLPCE 2779
Query: 421 VFASPAPDAVVW 432
P P + W
Sbjct: 2780 ASGIPRP-TITW 2790
Score = 71.6 bits (174), Expect = 2e-12
Identities = 111/474 (23%), Positives = 174/474 (36%), Gaps = 89/474 (18%)
Query: 70 PGWSRYWISGNAANGQHDLHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQV 128
PG Y ++G L + + +D Y C A+ +AG R + VLVPP
Sbjct: 1204 PGEDTYLLAGGWM-----LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENE 1258
Query: 129 LGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVEST 188
+ ++ G A+L C G P P+L WF+DG L H +P V
Sbjct: 1259 DLEEVIKVLDGQTAHLMCNVTG--HPQPKLTWFKDGRPLARGDAHHI-----SPDGV--L 1309
Query: 189 LTLTPFSHDDGATFVCRARSQALPTGRDTA-ITLSLQYPPEVTLSASPH-----TVQEGE 242
L + + + C A A G T LS+ P + A TV
Sbjct: 1310 LQVLQANLSSAGHYSCIA---ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNN 1366
Query: 243 KVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRL-------EVVADASFLTEPVSCEVSN 295
+ +C+A A P W K G+P +R +L +++ +C V+N
Sbjct: 1367 PISLICEALAFPS-PNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTN 1425
Query: 296 AVGSANRSTALDVLFGPILQAKPEP--------VSVDVGEDASFSCAWRGNPLPRVTWTR 347
+G A ++ ++VL P + +K +P V V + C P P + W +
Sbjct: 1426 ELGEAVKNYHVEVLIPPSI-SKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYK 1484
Query: 348 RGGA-------QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPV 400
G QVLG G L++ D+G Y+C A ++G + + + PP+
Sbjct: 1485 DGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVA-TNVAG--EDDQDFNVLIQVPPM 1541
Query: 401 VTALHSAPAFL---------------------RGPARLQCLVFASPAPDAVVWSWDEGFL 439
+ A PA L C A P PD + W ++ L
Sbjct: 1542 FQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPD-LTWYREDQPL 1600
Query: 440 EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGE 493
AG + L +GG VL I + + R ++C A N +GE
Sbjct: 1601 SAGDEVSVL---------QGG------RVLQIPLVRAENAGR-YSCKASNEVGE 1638
Score = 69.7 bits (169), Expect = 9e-12
Identities = 119/458 (25%), Positives = 163/458 (35%), Gaps = 93/458 (20%)
Query: 88 LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPP----------------EAPQVLG 130
L I+P ++ D Y C AT AG + + + VPP + G
Sbjct: 1504 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARG 1563
Query: 131 GPSV--SLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVEST 188
G + +V PA L C + +A P P+L W+R+ L A ++L+ G
Sbjct: 1564 GVTEYREIVENNPAYLYCDT--NAIPPPDLTWYREDQPL-SAGDEVSVLQGG------RV 1614
Query: 189 LTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE-----GEK 243
L + ++ + C+A ++ G D L P V L + V+E
Sbjct: 1615 LQIPLVRAENAGRYSCKASNE---VGEDWLHYELLVLTPPVILGDTEELVEEVTVNASST 1671
Query: 244 VIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS---------CEVS 294
V C A PV W + G P + PRL+V+ D L + C
Sbjct: 1672 VSLQCPALGN-PVPTISWLQNGLPF--SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAE 1728
Query: 295 NAVGSANRSTALDVLFGP-ILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQV 353
N GSA + L V P I E V+ + S C +P P VTW + A
Sbjct: 1729 NQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALS 1788
Query: 354 LGSGA-------TLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHS 406
LG TL+L D+G Y C A L+ +L+V PP A
Sbjct: 1789 LGEEVFLLPGTHTLQLGRARLSDSGMYTCEA---LNAAGRDQKLVQLSVLVPP---AFRQ 1842
Query: 407 APAFLRGP-----------ARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAP 455
AP RGP A L C A P P V W D G+ LV
Sbjct: 1843 AP---RGPQDAVLVRVGDKAVLSCETDALPEP-TVTWYKD---------GQPLVLAQRTQ 1889
Query: 456 ESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGE 493
RGG L I Q SD ++C N GE
Sbjct: 1890 ALRGG------QRLEIQEAQVSD-KGLYSCKVSNVAGE 1920
Score = 49.7 bits (117), Expect = 9e-06
Identities = 57/230 (24%), Positives = 82/230 (35%), Gaps = 49/230 (21%)
Query: 251 TAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS--------CEVSNAVGSANR 302
T +P VT W KG S P + V+ + S VS C+ +N VGS +R
Sbjct: 29 TPKPQVT---WRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSR 85
Query: 303 STALDVLFGPILQ--AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRR------------ 348
L V P ++ + VS G+ + C G P+P + W +
Sbjct: 86 RAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAG 145
Query: 349 ----------GGAQVLGSGATLRLPSVGPEDAGDYVCRA----------EAGLSGLRGGA 388
GG ++L G +L P + P +G +A AGL+G
Sbjct: 146 YGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFP 205
Query: 389 AEARLTVNAPPVVTALHSAPAFL---RGPARLQCLVFASPAPDAVVWSWD 435
+ APP V +A L LQC P P V W+ D
Sbjct: 206 TPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQ-VEWTKD 254
Score = 47.0 bits (110), Expect = 6e-05
Identities = 44/130 (33%), Positives = 60/130 (46%), Gaps = 24/130 (18%)
Query: 321 VSVDVGEDASFSCAWRGNPLPRVTWTR---------RGGAQVLGSGATLRLPSVGPEDAG 371
V++ VG +A C G P P+VTW + + G VL G+ L L SV P D+G
Sbjct: 13 VALTVGLEAG-GCGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGS-LFLASVSPADSG 70
Query: 372 DYVCRA--EAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPA----RLQCLVFASP 425
DY C+A E G + R A+L V PP + A + G A L+C P
Sbjct: 71 DYECQATNEVGSTSRR-----AKLVVYVPPSIRE-DGRKANVSGMAGQSLTLECDANGFP 124
Query: 426 APDAVVWSWD 435
P+ +VW D
Sbjct: 125 VPE-IVWLKD 133
Score = 32.7 bits (73), Expect = 1.2
Identities = 33/118 (27%), Positives = 52/118 (44%), Gaps = 14/118 (11%)
Query: 23 SPHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNA 81
+P F +P+D+ V G++ L C A G ++W ++G L R L R G+
Sbjct: 3117 APVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRL----RTLPDGS- 3171
Query: 82 ANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAG 139
L + VE D +Y+C A L S A+ ++V E PQ G ++ G
Sbjct: 3172 ------LWLENVETGDAGTYDCVAHNL-LGSATARAFLVVRGE-PQGSWGSMTGVING 3221
>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
sapiens]
Length = 790
Score = 100 bits (250), Expect = 4e-21
Identities = 94/326 (28%), Positives = 144/326 (44%), Gaps = 32/326 (9%)
Query: 83 NGQHDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVP 141
+G I +E +YEC A ++AG AQ+ V PP PQ++ P+V++ G
Sbjct: 475 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPP--PQLVPAPNVTVSPGET 532
Query: 142 ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 201
A L+CR G+A L W RD +L +T L + +L ++ DG
Sbjct: 533 AVLSCRVLGEA--PYNLTWVRDWRVLPASTGRVAQL-------ADLSLEISGIIPTDGGR 583
Query: 202 FVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRW 261
+ C A S A R ++ L ++ P+V++ S +G +V C A+ P W
Sbjct: 584 YQCVA-SNANGVTR-ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYP-TPHISW 640
Query: 262 AKGGSPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFGPI 313
++ + R+ V A + + + V SC+ +N VG+ + L P
Sbjct: 641 SRESQAL--QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 698
Query: 314 LQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVL----GSGATLRLPSVGPED 369
+ A V V VGE+A C G P PRV W R G +L S LR+P+ D
Sbjct: 699 VSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERD 758
Query: 370 AGDYVCRAEAGLSGLRGGAAEARLTV 395
AG Y CRA ++ L +AE +L V
Sbjct: 759 AGTYTCRA---VNELGDASAEIQLAV 781
>gi|21686977 cell adhesion molecule 4 [Homo sapiens]
Length = 388
Score = 100 bits (250), Expect = 4e-21
Identities = 93/316 (29%), Positives = 130/316 (41%), Gaps = 30/316 (9%)
Query: 12 LLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLV----QWTKSGLALGGQR 67
LL + AGP Q E++ V G A + C L Y G + + L G R
Sbjct: 11 LLLLWAAAAGPGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTR 70
Query: 68 DLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAP- 126
L R+ + + + + LEDE Y CQ + A L VLV PE P
Sbjct: 71 ALKD-ERFQLEEFSPRRVR-IRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPV 128
Query: 127 -----QVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGT 181
Q + G V L VP + RP L W+RD L G + Q + G
Sbjct: 129 VEVREQAVEGGEVELSCLVPRS---------RPAATLRWYRDRKELKGVSSSQ---ENGK 176
Query: 182 PGSVESTLTLTPFSHDDGATFVCRARSQALPTG--RDTAITLSLQYPPEVTLSASPHTVQ 239
SV ST+ DDG +C A++QALP+G + T L +QY P + AS V+
Sbjct: 177 VWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVR 236
Query: 240 EGEKVIFLCQATAQPPVTGYRWAKGGSPV---LGARGPRLEVVADASFLTEPVSCEVSNA 296
EG+ ++ C T P RW +G + A G L + S +CE SN
Sbjct: 237 EGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNK 296
Query: 297 VGSANRSTALDVLFGP 312
G A R+ + V++ P
Sbjct: 297 HGHA-RALYVLVVYDP 311
Score = 50.4 bits (119), Expect = 6e-06
Identities = 81/328 (24%), Positives = 118/328 (35%), Gaps = 41/328 (12%)
Query: 123 PEAPQVLGGPSVSLVAGVPANLTCRSRGD-------ARPTPELLWFRDGVLLDGATFHQT 175
P A Q + +V++ G A +TCR P + L+F L F
Sbjct: 21 PGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQ-- 78
Query: 176 LLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASP 235
L+E +P V + L+ +D + C+ ++ T A TL++ PE +
Sbjct: 79 -LEEFSPRRVR--IRLSDARLEDEGGYFCQLYTE--DTHHQIA-TLTVLVAPENPVVEVR 132
Query: 236 HTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGA-----RGPRLEVVADASFLTEP-- 288
EG +V C P RW + + G G V + F +
Sbjct: 133 EQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKD 192
Query: 289 ----VSCEVSNAVGSANRST----ALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPL 340
+ CE N + S LDV + P + V G+ +CA GNP
Sbjct: 193 DGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPR 252
Query: 341 P-RVTWTRRGGA---QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVN 396
P ++ W R + + G TL LP + D G Y C A S G A + V
Sbjct: 253 PNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEA----SNKHGHARALYVLVV 308
Query: 397 APP--VVTALHSAPAFLRGPARLQCLVF 422
P VV A S P + G L LVF
Sbjct: 309 YDPGAVVEAQTSVPYAIVG-GILALLVF 335
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 98.6 bits (244), Expect = 2e-20
Identities = 109/353 (30%), Positives = 143/353 (40%), Gaps = 55/353 (15%)
Query: 88 LHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPP--EAPQV-LGGPSVSLVAGVPAN 143
L IR V+L D +Y C + + A LHV AP V + P +++ G A
Sbjct: 1825 LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAE 1884
Query: 144 LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 203
C + G PTP L W G Q K G + L L D A ++
Sbjct: 1885 FRCSATGS--PTPTLEW-------TGGPGGQLPAKAQIHGGI---LRLPAVEPTDQAQYL 1932
Query: 204 CRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAK 263
CRA S A + + P V +S V G V C+A P T W K
Sbjct: 1933 CRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSAT-ITWRK 1991
Query: 264 -GGSPVLGARGPRLEVV---------ADASFLTEPVSCEVSNAVGSANRSTALDVLFGPI 313
GGS AR R ++ ADA F C ++ G+A + VL
Sbjct: 1992 EGGSLPPQARSERTDIATLLIPAITTADAGFYL----CVATSPAGTAQARIQVVVLSAS- 2046
Query: 314 LQAKPEPV-------SVDVGEDASFSCAWRGNPLPRVTWTRRGGA-----QVLGSGATLR 361
A P PV SV G+ +C G+ +VTW RRGG+ QV GS LR
Sbjct: 2047 -DASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGS--RLR 2103
Query: 362 LPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGP 414
LP V P D+G+YVCR E G G EA +TV+ V+ HS P++ P
Sbjct: 2104 LPQVSPADSGEYVCRVENG-----SGPKEASITVS---VLHGTHSGPSYTPVP 2148
Score = 91.7 bits (226), Expect = 2e-18
Identities = 144/526 (27%), Positives = 207/526 (39%), Gaps = 94/526 (17%)
Query: 30 PEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDL 88
P L V G+ A C A G+ ++WT GGQ LP ++ I G L
Sbjct: 1872 PPQLTVQPGQLAEFRCSATGSPTPTLEWTGGP---GGQ--LPAKAQ--IHGGI------L 1918
Query: 89 HIRPVELEDEASYECQA-TQAGLRSRPAQLHV--------LVPPEAPQVLGGPSVSL--- 136
+ VE D+A Y C+A + AG + A LHV V PE QV G +V L
Sbjct: 1919 RLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCR 1978
Query: 137 VAGVP-ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFS 195
AGVP A +T R G + P P+ R + +TL + +
Sbjct: 1979 AAGVPSATITWRKEGGSLP-PQARSERTDI---------------------ATLLIPAIT 2016
Query: 196 HDDGATFVCRARSQA-LPTGRDTAITLSLQ--YPPEVTLSASPHTVQEGEKVIFLC--QA 250
D ++C A S A R + LS PP V + +S +V EG+ + C
Sbjct: 2017 TADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAG 2076
Query: 251 TAQPPVTGYRWAKGGS--PVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDV 308
+A VT YR +GGS P G RL + + + C V N G S + V
Sbjct: 2077 SAHAQVTWYR--RGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134
Query: 309 LFG--------PI------LQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG---A 351
L G P+ ++ +P V G+ +C G +VTW +RGG A
Sbjct: 2135 LHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPA 2194
Query: 352 QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNA-------PPVVTAL 404
+ G+ LRL V P D+G+YVC G SG A +T+ A PPV
Sbjct: 2195 RHQTHGSLLRLHQVTPADSGEYVCHV-VGTSGPL--EASVLVTIEASVIPGPIPPVRIES 2251
Query: 405 HSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGR----FLVETFPAPES--- 457
S+ L C+V A A V W G L A Q R ++ + PA
Sbjct: 2252 SSSTVAEGQTLDLSCVV-AGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYV 2310
Query: 458 -RGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGR 502
R G + ++GTQ ++ + + R+ +Q + G+
Sbjct: 2311 CRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQ 2356
Score = 79.3 bits (194), Expect = 1e-14
Identities = 104/374 (27%), Positives = 145/374 (38%), Gaps = 49/374 (13%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P+ PE V GE +L C A G QW++ G +L G+ A
Sbjct: 3299 PYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGR--------------AT 3344
Query: 83 NGQHDLHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVP 141
LH ED Y C+ T + G AQL V PP + P+ S+ AG
Sbjct: 3345 ARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSL-----PATSIPAGST 3399
Query: 142 ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG---TPGSV--ESTLTLTPFSH 196
+ + + + + F V D T KEG PG + L +
Sbjct: 3400 PTVQVTPQLETKSIGASVEFHCAVPSDRGT-QLRWFKEGGQLPPGHSVQDGVLRIQNLDQ 3458
Query: 197 DDGATFVCRARSQALPTGRDTAIT-LSLQYPPEVTLS--ASPHTVQEGEKVIFLCQATAQ 253
T++C+A P G+ A L +Q P V ++ S TV G V F C A
Sbjct: 3459 SCQGTYICQAHG---PWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGD 3515
Query: 254 PPVTGYRWAKGGS---PVLGARGPRLEV----VADASFLTEPVSCEVSNAVGSANRSTAL 306
P W+K G P + G + + +ADA C +NA G+ L
Sbjct: 3516 PKPQ-VTWSKVGGHLRPGIVQSGGVVRIAHVELADAG----QYRCTATNAAGTTQSHVLL 3570
Query: 307 DVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGS---GATLRLP 363
V P + + P+ V V G A F C G P P ++W++ G+ S L LP
Sbjct: 3571 LVQALPQI-SMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLENNMLMLP 3629
Query: 364 SVGPEDAGDYVCRA 377
SV P+DAG YVC A
Sbjct: 3630 SVRPQDAGTYVCTA 3643
Score = 79.0 bits (193), Expect = 1e-14
Identities = 113/438 (25%), Positives = 154/438 (35%), Gaps = 44/438 (10%)
Query: 23 SPHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNA 81
+P + +L V G A L C A G+ + W+K L Q L G
Sbjct: 3211 APQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEG---------- 3260
Query: 82 ANGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGV 140
L I V +D Y C AT AG LHV PP A V SV AG
Sbjct: 3261 ----DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQ--AGE 3314
Query: 141 PANLTCRSRGDARPTPELLWFRDGVLLDG-ATFHQTLLKEGTPGSVESTLTLTPFSHDDG 199
L C + G P W R G L G AT LL +S ++ G
Sbjct: 3315 TVQLQCLAHGT--PPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVG 3372
Query: 200 ATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGY 259
+ P G A ++ P V ++ T G V F C A T
Sbjct: 3373 SAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHC-AVPSDRGTQL 3431
Query: 260 RWAKGGSPVLGARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFG 311
RW K G + P V D + + C+ G A S L +
Sbjct: 3432 RWFKEGGQL-----PPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQAL 3486
Query: 312 P--ILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG---AQVLGSGATLRLPSVG 366
P ++ + +V VG F C G+P P+VTW++ GG ++ SG +R+ V
Sbjct: 3487 PSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVVRIAHVE 3546
Query: 367 PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPA 426
DAG Y C A + + L V A P ++ A C+ P
Sbjct: 3547 LADAGQYRCTATNAAGTTQ---SHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASGYPT 3603
Query: 427 PDAVVWSWDEGFLEAGSQ 444
PD + WS +G L S+
Sbjct: 3604 PD-ISWSKLDGSLPPDSR 3620
Score = 77.0 bits (188), Expect = 5e-14
Identities = 109/462 (23%), Positives = 175/462 (37%), Gaps = 86/462 (18%)
Query: 23 SPHFLQQPEDLVVLLGEEARLPCALGAY-WGLVQWTKSGLALGGQRDLPGWSRYWISGNA 81
SP + V+ G+ L C + ++ W K G +L S +
Sbjct: 2629 SPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLP-------------SRHQ 2675
Query: 82 ANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEA----------PQVLGG 131
+G H L + + + D Y C+A + + A + + V P A P +
Sbjct: 2676 THGSH-LRLHQMSVADSGEYVCRANN-NIDALEASIVISVSPSAGSPSAPGSSMPIRIES 2733
Query: 132 PSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTL 191
S + G +L C G A ++ W + G L + HQT S L L
Sbjct: 2734 SSSHVAEGETLDLNCVVPGQAHA--QVTWHKRGGSLP--SHHQTR---------GSRLRL 2780
Query: 192 TPFSHDDGATFVCRARSQALPTGRDTAITL------SLQYP-----PEVTLSASPHTVQE 240
S D +VCR + P +T+ ++ P P + + S V E
Sbjct: 2781 HHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAE 2840
Query: 241 GEKVIFLCQATAQPPVTGYRWAKGGSPVLGAR----GPRLEVVADASFLTEPVSCEVSNA 296
G+ + C Q +GG+ L AR GP L + + + SC+V+ +
Sbjct: 2841 GQTLDLKCVVPGQAHAQVTWHKRGGN--LPARHQVHGPLLRLNQVSPADSGEYSCQVTGS 2898
Query: 297 VGSANRSTALDV---LFGPI-LQAKPEPVSVDV-------GEDASFSCAWRGNPLPRVTW 345
G+ S + + GPI +P+ ++ G+ +C G +VTW
Sbjct: 2899 SGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTW 2958
Query: 346 TRRGG---AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAP---- 398
+RGG A+ G+ LRL V P D+G+YVCRA +G G EA TV P
Sbjct: 2959 YKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASG----PGPEQEASFTVTVPPSEG 3014
Query: 399 -------PVVTALHSAPAFLRG-PARLQCLVFASPAPDAVVW 432
PV++ + +G A +CL+ AP ++ W
Sbjct: 3015 SSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEW 3056
Score = 77.0 bits (188), Expect = 5e-14
Identities = 86/327 (26%), Positives = 124/327 (37%), Gaps = 29/327 (8%)
Query: 97 DEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPT 155
+ +Y C A+ A G+ L V PP + GP V + G L C S G+ R +
Sbjct: 3085 NHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGP-VWVKVGKAVTLECVSAGEPRSS 3143
Query: 156 PELLWFRDGVLLDGATFHQTLLKEGTPGSVES--TLTLTPFSHDDGATFVCRARSQALPT 213
W R + L++ T G ++S L ++ D T+VC A++ AL T
Sbjct: 3144 AR--WTR-------ISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQN-ALGT 3193
Query: 214 GR---DTAITLSLQYP--PEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPV 268
+ + + P P+V + TV+ G C AT P T W+K SP+
Sbjct: 3194 AQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPT-IHWSKLRSPL 3252
Query: 269 LGAR---GPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDV 325
G L + A + C ++ G A + L V P PE SV
Sbjct: 3253 PWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQA 3312
Query: 326 GEDASFSCAWRGNPLPRVTWTRRGGA---QVLGSGATLRLPSVGPEDAGDYVCRAEAGLS 382
GE C G P W+R G + + L PED+G Y CR +
Sbjct: 3313 GETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRV---TN 3369
Query: 383 GLRGGAAEARLTVNAPPVVTALHSAPA 409
+ A A+L V PP S PA
Sbjct: 3370 KVGSAEAFAQLLVQGPPGSLPATSIPA 3396
Score = 73.9 bits (180), Expect = 5e-13
Identities = 105/450 (23%), Positives = 162/450 (36%), Gaps = 79/450 (17%)
Query: 21 GPSPHFLQQPEDLVVLLGEEARLPCAL-GAYWGLVQWTKSGLALGGQRDLPGWSRYWISG 79
GP P + V G+ L C + G V W K G +L + + G Y
Sbjct: 2242 GPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQA 2301
Query: 80 NAANGQHDLHIRPVELEDEASYECQATQAGLRSRPA--QLHVLVPPEAPQVLGGPSVSLV 137
+ A+ + +E + TQ + PA + + P + QV G ++ L
Sbjct: 2302 SPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLN 2361
Query: 138 AGVP----ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTP 193
VP A +T RG + P ++ T GS+ L L
Sbjct: 2362 CVVPGQSHAQVTWHKRGGSLP----------------------VRHQTHGSL---LRLYQ 2396
Query: 194 FSHDDGATFVCRARSQALPTGRDTAITL-------SLQYPPEVTLSASPHTVQEGEKVIF 246
S D +VCR ++P +T+ +L P V + +S V EG+ +
Sbjct: 2397 ASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDL 2456
Query: 247 LCQATAQPPVTGYRWAKGGSPVLGAR----GPRLEVVADASFLTEPVSCEVSNAVGSANR 302
C Q +GGS L AR G RL ++ + C V + G+
Sbjct: 2457 NCLVAGQAHAQVTWHKRGGS--LPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEA 2514
Query: 303 STALDV---LFGPILQAKPEPVSVDV-------GEDASFSCAWRGNPLPRVTWTRRGGA- 351
S + + L G Q PV ++ G +C +TW +RGG+
Sbjct: 2515 SVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL 2574
Query: 352 ----QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTV-----------N 396
Q++GS LR+P V P D+G+YVC G G+ E L V +
Sbjct: 2575 PSRHQIVGS--RLRIPQVTPADSGEYVCHVSNG-----AGSRETSLIVTIQGSGSSHVPS 2627
Query: 397 APPVVTALHSAPAFLRGPA-RLQCLVFASP 425
P + S+P + G L C+V P
Sbjct: 2628 VSPPIRIESSSPTVVEGQTLDLNCVVARQP 2657
Score = 68.2 bits (165), Expect = 3e-11
Identities = 95/366 (25%), Positives = 135/366 (36%), Gaps = 63/366 (17%)
Query: 104 QATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSL---VAGVPANLTCRSRGDARPTPELLW 160
Q Q + A L V V P V G S SL V+G P + SR D RP P
Sbjct: 1664 QGGQCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQ 1723
Query: 161 FRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARS--QALPTGRDTA 218
R HQ S L D ++C R+ Q+ + +
Sbjct: 1724 QR----------HQG-----------SELHFPSVQPSDAGVYICTCRNLHQSNTSRAELL 1762
Query: 219 ITLSLQYPPEVTLSAS-PHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGP--- 274
+T + P VT+ +V+ G V F+C A ++ P W + + L R
Sbjct: 1763 VTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFN 1822
Query: 275 -----RLEVVADASFLTEPVSCEVSNAVGSANRSTALDV-----LFGPILQAKPEPVSVD 324
R ++DA C SN + L V L P++ P ++V
Sbjct: 1823 GILTIRNVQLSDAGTYV----CTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQ 1878
Query: 325 VGEDASFSCAWRGNPLPRVTWTRRGGAQVLGS----GATLRLPSVGPEDAGDYVCRA--E 378
G+ A F C+ G+P P + WT G Q+ G LRLP+V P D Y+CRA
Sbjct: 1879 PGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSS 1938
Query: 379 AGLSGLRG-----GAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWS 433
AG R G R+ V+ P T +H+ RL C P+ + W
Sbjct: 1939 AGQQVARAVLHVHGGGGPRVQVS--PERTQVHAGRT-----VRLYCRAAGVPSA-TITWR 1990
Query: 434 WDEGFL 439
+ G L
Sbjct: 1991 KEGGSL 1996
Score = 30.0 bits (66), Expect = 7.7
Identities = 22/99 (22%), Positives = 32/99 (32%), Gaps = 9/99 (9%)
Query: 288 PVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTR 347
P S +RS + ++ E + G+ +F+C G P P + W
Sbjct: 383 PASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRL 442
Query: 348 RGG---------AQVLGSGATLRLPSVGPEDAGDYVCRA 377
G G TL + V D G Y C A
Sbjct: 443 NWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEA 481
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor
[Homo sapiens]
Length = 1070
Score = 94.0 bits (232), Expect = 4e-19
Identities = 125/464 (26%), Positives = 169/464 (36%), Gaps = 67/464 (14%)
Query: 5 RVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGA------YWGL----V 54
R+P L VLL G + F++QP L G A L C + A YW L V
Sbjct: 13 RLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPV 72
Query: 55 QWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQA----TQAGL 110
Q T+ A G R L+D +++C A T
Sbjct: 73 QDTERRFAQGSSLSFAAVDR--------------------LQDSGTFQCVARDDVTGEEA 112
Query: 111 RSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGV-LLDG 169
RS A ++ P VL P+ +T R D P P WFRDG L DG
Sbjct: 113 RSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDG 172
Query: 170 ATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSL--QYPP 227
+ H T S E LTL P + + C A S TLS+ +
Sbjct: 173 QSNH-------TVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFA 225
Query: 228 EVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGP----RLEVVADAS 283
V L+ V E+ +F CQ +AQPP + + +P+ P R V A+ S
Sbjct: 226 RVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGS 285
Query: 284 FL---TEPVSCEVSNAVGSANRSTAL---DVLFGPILQAKP--EPVSVDVGEDASFSC-A 334
L P + + +G R + L ++ P EP G + +C
Sbjct: 286 LLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLP 345
Query: 335 WRGNPLPRVTWTRRG-----GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAA 389
+G P P V W G +V G L L ++ DAG Y C A A L+G R
Sbjct: 346 PKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHA-ANLAGQR--RQ 402
Query: 390 EARLTVNAPPVVTALHSAPAFLRG-PARLQCLVFASPAPDAVVW 432
+ +TV P G P L CL A+P P VVW
Sbjct: 403 DVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKP-TVVW 445
Score = 62.4 bits (150), Expect = 1e-09
Identities = 109/437 (24%), Positives = 155/437 (35%), Gaps = 50/437 (11%)
Query: 30 PEDLVVLLGEEARLPCALGAYWG-LVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDL 88
P+D+VV EEA C A +QW R P R + ANG L
Sbjct: 231 PQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRR--ATVFANGS--L 286
Query: 89 HIRPVELEDEASYECQATQAGLRSRP----AQLHVLVPPEAPQVLGGPSVSLVAGVPANL 144
+ V + Y C G R P A LH+ + P L P V AG +
Sbjct: 287 LLTQVRPRNAGIYRCIGQ--GQRGPPIILEATLHLAEIEDMP--LFEPRV-FTAGSEERV 341
Query: 145 TCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVC 204
TC P P + W GV L H + ++G L L + D + C
Sbjct: 342 TCLPP-KGLPEPSVWWEHAGVRLPT---HGRVYQKG------HELVLANIAESDAGVYTC 391
Query: 205 RARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLC--QATAQPPVTGYRWA 262
A + A +D IT++ P ++EG+ C QAT +P V YR
Sbjct: 392 HAANLAGQRRQDVNITVATV--PSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYR-- 447
Query: 263 KGGSPVLGARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFGPIL 314
+ +L + R EV + + V C S GS + VL
Sbjct: 448 ---NQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKF 504
Query: 315 QAKPEPVS-VDVGEDASFSCAWRGNPLPRVTWTRRGGAQ----VLGSGATLRLPSVGPED 369
P+P ++ ++A+ C+ G P + W R G+ V + TL V +D
Sbjct: 505 TPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDD 564
Query: 370 AGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRG-PARLQCLVFASPAPD 428
AG+Y C A G G A +LTV +G A LQC P P
Sbjct: 565 AGNYTCIASNGPQGQI--RAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKP- 621
Query: 429 AVVWSWDEGFLEAGSQG 445
+ W + L+ G
Sbjct: 622 LIQWKGKDRILDPTKLG 638
Score = 53.9 bits (128), Expect = 5e-07
Identities = 86/368 (23%), Positives = 131/368 (35%), Gaps = 51/368 (13%)
Query: 31 EDLVVLLGEEARLPCA--LGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDL 88
E V G E R+ C G V W +G+ L P R + G H+L
Sbjct: 329 EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRL------PTHGRVYQKG------HEL 376
Query: 89 HIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVS-LVAGVPANLTC 146
+ + D Y C A AG R + + V P L P S L G P L C
Sbjct: 377 VLANIAESDAGVYTCHAANLAGQRRQDVNITVAT---VPSWLKKPQDSQLEEGKPGYLDC 433
Query: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 206
++ A P P ++W+R+ +L+ + + + K GT L + DG + C +
Sbjct: 434 LTQ--ATPKPTVVWYRNQMLISEDSRFE-VFKNGT-------LRINSVEVYDGTWYRCMS 483
Query: 207 RSQA--LPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFL-CQATAQPPVTGYRWAK 263
+ A + + L++ P P E +K + C AT + T +W +
Sbjct: 484 STPAGSIEAQARVQVLEKLKFTPP----PQPQQCMEFDKEATVPCSATGREKPT-IKWER 538
Query: 264 GGSPVLGA----RGPRLEVVADASFLTEPVSCEVSNAV-GSANRSTALDVLFGPILQAKP 318
L L +C SN G L V + +P
Sbjct: 539 ADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEP 598
Query: 319 EPVSVDVGEDASFSCAWRGNPLPRVTW---------TRRGGAQVLGSGATLRLPSVGPED 369
E +V G A C +G+P P + W T+ G + +L + V PED
Sbjct: 599 ERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPED 658
Query: 370 AGDYVCRA 377
+G Y C A
Sbjct: 659 SGRYTCIA 666
Score = 43.9 bits (102), Expect = 5e-04
Identities = 91/388 (23%), Positives = 129/388 (33%), Gaps = 44/388 (11%)
Query: 55 QWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQA---GLR 111
QW + G L G S + +S N L +RP E Y C A A
Sbjct: 161 QWFRDGTPLSD-----GQSNHTVSSKERN----LTLRPAGPEHSGLYSCCAHSAFGQACS 211
Query: 112 SRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLW-FRDGVLLDGA 170
S+ L + A VL V + A C+ A+P P L W F D +
Sbjct: 212 SQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQF--SAQPPPSLQWLFEDETPITNR 269
Query: 171 TFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVT 230
+ L + +L LT + + C + Q P A TL L ++
Sbjct: 270 SRPPHLRRATV--FANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEA-TLHLAEIEDMP 326
Query: 231 LSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGS--PVLGA---RGPRLEVVADASFL 285
L P G + C P W G P G +G L + A
Sbjct: 327 LF-EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESD 385
Query: 286 TEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTW 345
+C +N G + + V P KP+ ++ G+ C + P P V W
Sbjct: 386 AGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVW 445
Query: 346 TRR-------GGAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAP 398
R +V +G TLR+ SV D Y C +S G+ EA+ V
Sbjct: 446 YRNQMLISEDSRFEVFKNG-TLRINSVEVYDGTWYRC-----MSSTPAGSIEAQARVQ-- 497
Query: 399 PVVTALHSAPAFLRGPARLQCLVFASPA 426
V+ L P P QC+ F A
Sbjct: 498 -VLEKLKFTPP----PQPQQCMEFDKEA 520
>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor
[Homo sapiens]
Length = 1014
Score = 94.0 bits (232), Expect = 4e-19
Identities = 125/464 (26%), Positives = 169/464 (36%), Gaps = 67/464 (14%)
Query: 5 RVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGA------YWGL----V 54
R+P L VLL G + F++QP L G A L C + A YW L V
Sbjct: 13 RLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPV 72
Query: 55 QWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQA----TQAGL 110
Q T+ A G R L+D +++C A T
Sbjct: 73 QDTERRFAQGSSLSFAAVDR--------------------LQDSGTFQCVARDDVTGEEA 112
Query: 111 RSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGV-LLDG 169
RS A ++ P VL P+ +T R D P P WFRDG L DG
Sbjct: 113 RSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDG 172
Query: 170 ATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSL--QYPP 227
+ H T S E LTL P + + C A S TLS+ +
Sbjct: 173 QSNH-------TVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFA 225
Query: 228 EVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGP----RLEVVADAS 283
V L+ V E+ +F CQ +AQPP + + +P+ P R V A+ S
Sbjct: 226 RVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGS 285
Query: 284 FL---TEPVSCEVSNAVGSANRSTAL---DVLFGPILQAKP--EPVSVDVGEDASFSC-A 334
L P + + +G R + L ++ P EP G + +C
Sbjct: 286 LLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLP 345
Query: 335 WRGNPLPRVTWTRRG-----GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAA 389
+G P P V W G +V G L L ++ DAG Y C A A L+G R
Sbjct: 346 PKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHA-ANLAGQR--RQ 402
Query: 390 EARLTVNAPPVVTALHSAPAFLRG-PARLQCLVFASPAPDAVVW 432
+ +TV P G P L CL A+P P VVW
Sbjct: 403 DVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKP-TVVW 445
Score = 61.2 bits (147), Expect = 3e-09
Identities = 95/374 (25%), Positives = 136/374 (36%), Gaps = 46/374 (12%)
Query: 30 PEDLVVLLGEEARLPCALGAYWG-LVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDL 88
P+D+VV EEA C A +QW R P R + ANG L
Sbjct: 231 PQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRR--ATVFANGS--L 286
Query: 89 HIRPVELEDEASYECQATQAGLRSRP----AQLHVLVPPEAPQVLGGPSVSLVAGVPANL 144
+ V + Y C G R P A LH+ + P L P V AG +
Sbjct: 287 LLTQVRPRNAGIYRCIGQ--GQRGPPIILEATLHLAEIEDMP--LFEPRV-FTAGSEERV 341
Query: 145 TCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVC 204
TC P P + W GV L H + ++G L L + D + C
Sbjct: 342 TCLPP-KGLPEPSVWWEHAGVRLPT---HGRVYQKG------HELVLANIAESDAGVYTC 391
Query: 205 RARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLC--QATAQPPVTGYRWA 262
A + A +D IT++ P ++EG+ C QAT +P V YR
Sbjct: 392 HAANLAGQRRQDVNITVATV--PSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYR-- 447
Query: 263 KGGSPVLGARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFGPIL 314
+ +L + R EV + + V C S GS + VL
Sbjct: 448 ---NQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKF 504
Query: 315 QAKPEPVS-VDVGEDASFSCAWRGNPLPRVTWTRRGGAQ----VLGSGATLRLPSVGPED 369
P+P ++ ++A+ C+ G P + W R G+ V + TL V +D
Sbjct: 505 TPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDD 564
Query: 370 AGDYVCRAEAGLSG 383
AG+Y C A G G
Sbjct: 565 AGNYTCIASNGPQG 578
Score = 43.9 bits (102), Expect = 5e-04
Identities = 91/388 (23%), Positives = 129/388 (33%), Gaps = 44/388 (11%)
Query: 55 QWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQA---GLR 111
QW + G L G S + +S N L +RP E Y C A A
Sbjct: 161 QWFRDGTPLSD-----GQSNHTVSSKERN----LTLRPAGPEHSGLYSCCAHSAFGQACS 211
Query: 112 SRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLW-FRDGVLLDGA 170
S+ L + A VL V + A C+ A+P P L W F D +
Sbjct: 212 SQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQF--SAQPPPSLQWLFEDETPITNR 269
Query: 171 TFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVT 230
+ L + +L LT + + C + Q P A TL L ++
Sbjct: 270 SRPPHLRRATV--FANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEA-TLHLAEIEDMP 326
Query: 231 LSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGS--PVLGA---RGPRLEVVADASFL 285
L P G + C P W G P G +G L + A
Sbjct: 327 LF-EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESD 385
Query: 286 TEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTW 345
+C +N G + + V P KP+ ++ G+ C + P P V W
Sbjct: 386 AGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVW 445
Query: 346 TRR-------GGAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAP 398
R +V +G TLR+ SV D Y C +S G+ EA+ V
Sbjct: 446 YRNQMLISEDSRFEVFKNG-TLRINSVEVYDGTWYRC-----MSSTPAGSIEAQARVQ-- 497
Query: 399 PVVTALHSAPAFLRGPARLQCLVFASPA 426
V+ L P P QC+ F A
Sbjct: 498 -VLEKLKFTPP----PQPQQCMEFDKEA 520
Score = 42.4 bits (98), Expect = 0.002
Identities = 75/327 (22%), Positives = 115/327 (35%), Gaps = 42/327 (12%)
Query: 31 EDLVVLLGEEARLPCA--LGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDL 88
E V G E R+ C G V W +G+ L P R + G H+L
Sbjct: 329 EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRL------PTHGRVYQKG------HEL 376
Query: 89 HIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVS-LVAGVPANLTC 146
+ + D Y C A AG R + + V P L P S L G P L C
Sbjct: 377 VLANIAESDAGVYTCHAANLAGQRRQDVNITVAT---VPSWLKKPQDSQLEEGKPGYLDC 433
Query: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 206
++ A P P ++W+R+ +L+ + + + K GT L + DG + C +
Sbjct: 434 LTQ--ATPKPTVVWYRNQMLISEDSRFE-VFKNGT-------LRINSVEVYDGTWYRCMS 483
Query: 207 RSQA--LPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFL-CQATAQPPVTGYRWAK 263
+ A + + L++ P P E +K + C AT + T +W +
Sbjct: 484 STPAGSIEAQARVQVLEKLKFTPP----PQPQQCMEFDKEATVPCSATGREKPT-IKWER 538
Query: 264 GGSPVLGA----RGPRLEVVADASFLTEPVSCEVSNAV-GSANRSTALDVLFGPILQAKP 318
L L +C SN G L V + +P
Sbjct: 539 ADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEP 598
Query: 319 EPVSVDVGEDASFSCAWRGNPLPRVTW 345
E +V G A C +G+P P + W
Sbjct: 599 ERTTVYQGHTALLQCEAQGDPKPLIQW 625
>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor
[Homo sapiens]
Length = 1030
Score = 94.0 bits (232), Expect = 4e-19
Identities = 125/464 (26%), Positives = 169/464 (36%), Gaps = 67/464 (14%)
Query: 5 RVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGA------YWGL----V 54
R+P L VLL G + F++QP L G A L C + A YW L V
Sbjct: 13 RLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPV 72
Query: 55 QWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQA----TQAGL 110
Q T+ A G R L+D +++C A T
Sbjct: 73 QDTERRFAQGSSLSFAAVDR--------------------LQDSGTFQCVARDDVTGEEA 112
Query: 111 RSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGV-LLDG 169
RS A ++ P VL P+ +T R D P P WFRDG L DG
Sbjct: 113 RSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDG 172
Query: 170 ATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSL--QYPP 227
+ H T S E LTL P + + C A S TLS+ +
Sbjct: 173 QSNH-------TVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFA 225
Query: 228 EVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGP----RLEVVADAS 283
V L+ V E+ +F CQ +AQPP + + +P+ P R V A+ S
Sbjct: 226 RVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGS 285
Query: 284 FL---TEPVSCEVSNAVGSANRSTAL---DVLFGPILQAKP--EPVSVDVGEDASFSC-A 334
L P + + +G R + L ++ P EP G + +C
Sbjct: 286 LLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLP 345
Query: 335 WRGNPLPRVTWTRRG-----GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAA 389
+G P P V W G +V G L L ++ DAG Y C A A L+G R
Sbjct: 346 PKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHA-ANLAGQR--RQ 402
Query: 390 EARLTVNAPPVVTALHSAPAFLRG-PARLQCLVFASPAPDAVVW 432
+ +TV P G P L CL A+P P VVW
Sbjct: 403 DVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKP-TVVW 445
Score = 50.1 bits (118), Expect = 7e-06
Identities = 82/363 (22%), Positives = 132/363 (36%), Gaps = 81/363 (22%)
Query: 31 EDLVVLLGEEARLPCA--LGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDL 88
E V G E R+ C G V W +G+ L P R + G H+L
Sbjct: 329 EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRL------PTHGRVYQKG------HEL 376
Query: 89 HIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVS-LVAGVPANLTC 146
+ + D Y C A AG R + + V P L P S L G P L C
Sbjct: 377 VLANIAESDAGVYTCHAANLAGQRRQDVNITVAT---VPSWLKKPQDSQLEEGKPGYLDC 433
Query: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 206
++ A P P ++W+R+ +L+ + + + K GT L + DG + C +
Sbjct: 434 LTQ--ATPKPTVVWYRNQMLISEDSRFE-VFKNGT-------LRINSVEVYDGTWYRCMS 483
Query: 207 RSQALPTGRDTAITLSLQYPPEVTL---SASPHTVQEGEKVIFLCQATAQPPVTGYRWAK 263
+ P G S++ V + S+ P V + + + T R
Sbjct: 484 ST---PAG-------SIEAQARVQVLDGSSLPEWVTDNAGTLHFARVT--------RDDA 525
Query: 264 GGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSV 323
G + + GP+ ++ A + A+ + F + +PE +V
Sbjct: 526 GNYTCIASNGPQGQIRAHVQL------------------TVAVFITF----KVEPERTTV 563
Query: 324 DVGEDASFSCAWRGNPLPRVTW---------TRRGGAQVLGSGATLRLPSVGPEDAGDYV 374
G A C +G+P P + W T+ G + +L + V PED+G Y
Sbjct: 564 YQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYT 623
Query: 375 CRA 377
C A
Sbjct: 624 CIA 626
Score = 42.4 bits (98), Expect = 0.002
Identities = 83/357 (23%), Positives = 119/357 (33%), Gaps = 37/357 (10%)
Query: 55 QWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQA---GLR 111
QW + G L G S + +S N L +RP E Y C A A
Sbjct: 161 QWFRDGTPLSD-----GQSNHTVSSKERN----LTLRPAGPEHSGLYSCCAHSAFGQACS 211
Query: 112 SRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLW-FRDGVLLDGA 170
S+ L + A VL V + A C+ A+P P L W F D +
Sbjct: 212 SQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQF--SAQPPPSLQWLFEDETPITNR 269
Query: 171 TFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVT 230
+ L + +L LT + + C + Q P A TL L ++
Sbjct: 270 SRPPHLRRATV--FANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEA-TLHLAEIEDMP 326
Query: 231 LSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGS--PVLGA---RGPRLEVVADASFL 285
L P G + C P W G P G +G L + A
Sbjct: 327 LF-EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESD 385
Query: 286 TEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTW 345
+C +N G + + V P KP+ ++ G+ C + P P V W
Sbjct: 386 AGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVW 445
Query: 346 TRR-------GGAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTV 395
R +V +G TLR+ SV D Y C +S G+ EA+ V
Sbjct: 446 YRNQMLISEDSRFEVFKNG-TLRINSVEVYDGTWYRC-----MSSTPAGSIEAQARV 496
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 92.0 bits (227), Expect = 2e-18
Identities = 107/407 (26%), Positives = 157/407 (38%), Gaps = 48/407 (11%)
Query: 126 PQVLGGPSVSLVA-GVPANLTCRSRGDARPTPELLWFRDGVLL----DGATFHQTLLKEG 180
P+++ PS +V+ G PA L C++ G RPTP + W++ G + D H+ LL G
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEG--RPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 181 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYP---PEVTLSASPHT 237
+ + + S D +VC AR+ G + SL+ + + S
Sbjct: 87 SLFFLR--IVHGRKSRPDEGVYVCVARNYL---GEAVSHNASLEVAILRDDFRQNPSDVM 141
Query: 238 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPV------LGARGPRLEVVADASFLTEPVSC 291
V GE + CQ P W K GSP+ + RG +L + C
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 201
Query: 292 EVSNAVGSANRSTA-LDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG 350
+N VG A L VL P +P ++V V + A F C RG+P+P V W + G
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261
Query: 351 -----AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNA------PP 399
+ TL++ V D G Y C AE + G AEA T+ P
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMV-----GKAEASATLTVQVGSEPPH 316
Query: 400 VVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRG 459
V L QC +P P A+ W GSQ L+ ++ P+S
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWR------REGSQN--LLFSYQPPQSSS 367
Query: 460 GLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLL 506
L I+ Q SD + C N G +A L D++
Sbjct: 368 RFSVSQTGDLTITNVQRSDVG-YYICQTLNVAGSIITKAYLEVTDVI 413
Score = 82.8 bits (203), Expect = 1e-15
Identities = 114/448 (25%), Positives = 161/448 (35%), Gaps = 57/448 (12%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P ++ P DL+V GE A L C A G ++W K G + +D P R + +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 83 NGQHDLHIRPVELEDEASYECQATQ--AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVA-G 139
+H R DE Y C A S A L V + + PS +VA G
Sbjct: 89 FFLRIVHGRK-SRPDEGVYVCVARNYLGEAVSHNASLEVAILRD--DFRQNPSDVMVAVG 145
Query: 140 VPANLTCR-SRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDD 198
PA + C+ RG P P + W +DG LD T+ L +T D
Sbjct: 146 EPAVMECQPPRG--HPEPTISWKKDGSPLDDKDERITIR--------GGKLMITYTRKSD 195
Query: 199 GATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTG 258
+VC + + A L++ P S V + F C+A PV
Sbjct: 196 AGKYVCVGTNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPT 253
Query: 259 YRWAKGGSPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLF 310
RW K + + R E+ D + V +C N VG A S L V
Sbjct: 254 VRWRKDDGELPKS---RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
Query: 311 G---PILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGS----------- 356
G P KP V +G +F C GNP P + W R G +L S
Sbjct: 311 GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 357 ---GATLRLPSVGPEDAGDYVCRA--EAGLSGLRGGAAEARLTVNAPPVVTALHSAP--- 408
L + +V D G Y+C+ AG + + + PP V + P
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV--IRQGPVNQ 428
Query: 409 -AFLRGPARLQCLVFASPAPDAVVWSWD 435
+ G L C+ SP P ++W D
Sbjct: 429 TVAVDGTFVLSCVATGSPVP-TILWRKD 455
Score = 65.5 bits (158), Expect = 2e-10
Identities = 103/461 (22%), Positives = 161/461 (34%), Gaps = 64/461 (13%)
Query: 26 FLQQPEDLVVLLGEEARLPCA--LGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAAN 83
F Q P D++V +GE A + C G + W K G L + + R I G
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-----RITIRGGK-- 185
Query: 84 GQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPS-VSLVAGVPA 142
L I D Y C T + R +++ L E P + PS +++ A
Sbjct: 186 ----LMITYTRKSDAGKYVCVGTNM-VGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
Query: 143 NLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATF 202
C +RGD P P + W +D DG L K + TL + + D ++
Sbjct: 241 EFKCEARGD--PVPTVRWRKD----DGE-----LPKSRYEIRDDHTLKIRKVTAGDMGSY 289
Query: 203 VCRARSQALPTGRDTAITLSL-QYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRW 261
C A + +T+ + PP + V G V F C+AT P +
Sbjct: 290 TCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWR 349
Query: 262 AKGGSPVLGARGP-----RLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDV 308
+G +L + P R V V C+ N GS L+V
Sbjct: 350 REGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Query: 309 LFGPILQAKPEPV------SVDVGEDASF--SCAWRGNPLPRVTWTRRGG---------A 351
++ +P PV + V D +F SC G+P+P + W + G
Sbjct: 410 T--DVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIK 467
Query: 352 QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFL 411
Q+ +R +G D G Y C A SG +A + PV + P +
Sbjct: 468 QLENGVLQIRYAKLG--DTGRYTCIASTP-SGEATWSAYIEVQEFGVPVQPPRPTDPNLI 524
Query: 412 RGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETF 452
P+ + + V SW + +++E F
Sbjct: 525 --PSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF 563
Score = 58.5 bits (140), Expect = 2e-08
Identities = 74/301 (24%), Positives = 109/301 (36%), Gaps = 46/301 (15%)
Query: 225 YPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVA 280
+PP + S V +GE C+A +P T W KGG V R R+ + +
Sbjct: 27 FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT-IEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 281 DASFLTEPVS------------CEVSNAVGSA-NRSTALDV-LFGPILQAKPEPVSVDVG 326
+ F V C N +G A + + +L+V + + P V V VG
Sbjct: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
Query: 327 EDASFSC-AWRGNPLPRVTWTRRGG------AQVLGSGATLRLPSVGPEDAGDYVCRAEA 379
E A C RG+P P ++W + G ++ G L + DAG YVC
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC-VGT 204
Query: 380 GLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFL 439
+ G R + P V + + A +C P P V W D+G L
Sbjct: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-TVRWRKDDGEL 263
Query: 440 EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQAS 499
P+SR + L I D S+ C A N +G+ A A+
Sbjct: 264 ---------------PKSRYEIRDD--HTLKIRKVTAGDMG-SYTCVAENMVGKAEASAT 305
Query: 500 L 500
L
Sbjct: 306 L 306
Score = 46.2 bits (108), Expect = 1e-04
Identities = 43/150 (28%), Positives = 58/150 (38%), Gaps = 11/150 (7%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGL--ALGGQRDLPGWSRYWISGN 80
PHF+ +P D VV LG C A G + W + G L + SR+ +S
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 374
Query: 81 AANGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHV--LVPPEAPQVLGGPSVSLV 137
DL I V+ D Y CQ AG A L V ++ P V+ V+
Sbjct: 375 G-----DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 138 AGVPANLTCRSRGDARPTPELLWFRDGVLL 167
V P P +LW +DGVL+
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLV 459
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 92.0 bits (227), Expect = 2e-18
Identities = 107/407 (26%), Positives = 157/407 (38%), Gaps = 48/407 (11%)
Query: 126 PQVLGGPSVSLVA-GVPANLTCRSRGDARPTPELLWFRDGVLL----DGATFHQTLLKEG 180
P+++ PS +V+ G PA L C++ G RPTP + W++ G + D H+ LL G
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEG--RPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 181 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYP---PEVTLSASPHT 237
+ + + S D +VC AR+ G + SL+ + + S
Sbjct: 87 SLFFLR--IVHGRKSRPDEGVYVCVARNYL---GEAVSHNASLEVAILRDDFRQNPSDVM 141
Query: 238 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPV------LGARGPRLEVVADASFLTEPVSC 291
V GE + CQ P W K GSP+ + RG +L + C
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 201
Query: 292 EVSNAVGSANRSTA-LDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG 350
+N VG A L VL P +P ++V V + A F C RG+P+P V W + G
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261
Query: 351 -----AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNA------PP 399
+ TL++ V D G Y C AE + G AEA T+ P
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMV-----GKAEASATLTVQVGSEPPH 316
Query: 400 VVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRG 459
V L QC +P P A+ W GSQ L+ ++ P+S
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWR------REGSQN--LLFSYQPPQSSS 367
Query: 460 GLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLL 506
L I+ Q SD + C N G +A L D++
Sbjct: 368 RFSVSQTGDLTITNVQRSDVG-YYICQTLNVAGSIITKAYLEVTDVI 413
Score = 82.8 bits (203), Expect = 1e-15
Identities = 114/448 (25%), Positives = 161/448 (35%), Gaps = 57/448 (12%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P ++ P DL+V GE A L C A G ++W K G + +D P R + +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 83 NGQHDLHIRPVELEDEASYECQATQ--AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVA-G 139
+H R DE Y C A S A L V + + PS +VA G
Sbjct: 89 FFLRIVHGRK-SRPDEGVYVCVARNYLGEAVSHNASLEVAILRD--DFRQNPSDVMVAVG 145
Query: 140 VPANLTCR-SRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDD 198
PA + C+ RG P P + W +DG LD T+ L +T D
Sbjct: 146 EPAVMECQPPRG--HPEPTISWKKDGSPLDDKDERITIR--------GGKLMITYTRKSD 195
Query: 199 GATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTG 258
+VC + + A L++ P S V + F C+A PV
Sbjct: 196 AGKYVCVGTNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPT 253
Query: 259 YRWAKGGSPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLF 310
RW K + + R E+ D + V +C N VG A S L V
Sbjct: 254 VRWRKDDGELPKS---RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
Query: 311 G---PILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGS----------- 356
G P KP V +G +F C GNP P + W R G +L S
Sbjct: 311 GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 357 ---GATLRLPSVGPEDAGDYVCRA--EAGLSGLRGGAAEARLTVNAPPVVTALHSAP--- 408
L + +V D G Y+C+ AG + + + PP V + P
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV--IRQGPVNQ 428
Query: 409 -AFLRGPARLQCLVFASPAPDAVVWSWD 435
+ G L C+ SP P ++W D
Sbjct: 429 TVAVDGTFVLSCVATGSPVP-TILWRKD 455
Score = 65.5 bits (158), Expect = 2e-10
Identities = 103/461 (22%), Positives = 161/461 (34%), Gaps = 64/461 (13%)
Query: 26 FLQQPEDLVVLLGEEARLPCA--LGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAAN 83
F Q P D++V +GE A + C G + W K G L + + R I G
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-----RITIRGGK-- 185
Query: 84 GQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPS-VSLVAGVPA 142
L I D Y C T + R +++ L E P + PS +++ A
Sbjct: 186 ----LMITYTRKSDAGKYVCVGTNM-VGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
Query: 143 NLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATF 202
C +RGD P P + W +D DG L K + TL + + D ++
Sbjct: 241 EFKCEARGD--PVPTVRWRKD----DGE-----LPKSRYEIRDDHTLKIRKVTAGDMGSY 289
Query: 203 VCRARSQALPTGRDTAITLSL-QYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRW 261
C A + +T+ + PP + V G V F C+AT P +
Sbjct: 290 TCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWR 349
Query: 262 AKGGSPVLGARGP-----RLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDV 308
+G +L + P R V V C+ N GS L+V
Sbjct: 350 REGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Query: 309 LFGPILQAKPEPV------SVDVGEDASF--SCAWRGNPLPRVTWTRRGG---------A 351
++ +P PV + V D +F SC G+P+P + W + G
Sbjct: 410 T--DVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIK 467
Query: 352 QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFL 411
Q+ +R +G D G Y C A SG +A + PV + P +
Sbjct: 468 QLENGVLQIRYAKLG--DTGRYTCIASTP-SGEATWSAYIEVQEFGVPVQPPRPTDPNLI 524
Query: 412 RGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETF 452
P+ + + V SW + +++E F
Sbjct: 525 --PSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF 563
Score = 58.5 bits (140), Expect = 2e-08
Identities = 74/301 (24%), Positives = 109/301 (36%), Gaps = 46/301 (15%)
Query: 225 YPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVA 280
+PP + S V +GE C+A +P T W KGG V R R+ + +
Sbjct: 27 FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT-IEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 281 DASFLTEPVS------------CEVSNAVGSA-NRSTALDV-LFGPILQAKPEPVSVDVG 326
+ F V C N +G A + + +L+V + + P V V VG
Sbjct: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
Query: 327 EDASFSC-AWRGNPLPRVTWTRRGG------AQVLGSGATLRLPSVGPEDAGDYVCRAEA 379
E A C RG+P P ++W + G ++ G L + DAG YVC
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC-VGT 204
Query: 380 GLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFL 439
+ G R + P V + + A +C P P V W D+G L
Sbjct: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-TVRWRKDDGEL 263
Query: 440 EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQAS 499
P+SR + L I D S+ C A N +G+ A A+
Sbjct: 264 ---------------PKSRYEIRDD--HTLKIRKVTAGDMG-SYTCVAENMVGKAEASAT 305
Query: 500 L 500
L
Sbjct: 306 L 306
Score = 46.2 bits (108), Expect = 1e-04
Identities = 43/150 (28%), Positives = 58/150 (38%), Gaps = 11/150 (7%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGL--ALGGQRDLPGWSRYWISGN 80
PHF+ +P D VV LG C A G + W + G L + SR+ +S
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 374
Query: 81 AANGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHV--LVPPEAPQVLGGPSVSLV 137
DL I V+ D Y CQ AG A L V ++ P V+ V+
Sbjct: 375 G-----DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 138 AGVPANLTCRSRGDARPTPELLWFRDGVLL 167
V P P +LW +DGVL+
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLV 459
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 92.0 bits (227), Expect = 2e-18
Identities = 107/407 (26%), Positives = 157/407 (38%), Gaps = 48/407 (11%)
Query: 126 PQVLGGPSVSLVA-GVPANLTCRSRGDARPTPELLWFRDGVLL----DGATFHQTLLKEG 180
P+++ PS +V+ G PA L C++ G RPTP + W++ G + D H+ LL G
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEG--RPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 181 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYP---PEVTLSASPHT 237
+ + + S D +VC AR+ G + SL+ + + S
Sbjct: 87 SLFFLR--IVHGRKSRPDEGVYVCVARNYL---GEAVSHNASLEVAILRDDFRQNPSDVM 141
Query: 238 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPV------LGARGPRLEVVADASFLTEPVSC 291
V GE + CQ P W K GSP+ + RG +L + C
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 201
Query: 292 EVSNAVGSANRSTA-LDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG 350
+N VG A L VL P +P ++V V + A F C RG+P+P V W + G
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261
Query: 351 -----AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNA------PP 399
+ TL++ V D G Y C AE + G AEA T+ P
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMV-----GKAEASATLTVQVGSEPPH 316
Query: 400 VVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRG 459
V L QC +P P A+ W GSQ L+ ++ P+S
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWR------REGSQN--LLFSYQPPQSSS 367
Query: 460 GLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLL 506
L I+ Q SD + C N G +A L D++
Sbjct: 368 RFSVSQTGDLTITNVQRSDVG-YYICQTLNVAGSIITKAYLEVTDVI 413
Score = 82.8 bits (203), Expect = 1e-15
Identities = 114/448 (25%), Positives = 161/448 (35%), Gaps = 57/448 (12%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P ++ P DL+V GE A L C A G ++W K G + +D P R + +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 83 NGQHDLHIRPVELEDEASYECQATQ--AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVA-G 139
+H R DE Y C A S A L V + + PS +VA G
Sbjct: 89 FFLRIVHGRK-SRPDEGVYVCVARNYLGEAVSHNASLEVAILRD--DFRQNPSDVMVAVG 145
Query: 140 VPANLTCR-SRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDD 198
PA + C+ RG P P + W +DG LD T+ L +T D
Sbjct: 146 EPAVMECQPPRG--HPEPTISWKKDGSPLDDKDERITIR--------GGKLMITYTRKSD 195
Query: 199 GATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTG 258
+VC + + A L++ P S V + F C+A PV
Sbjct: 196 AGKYVCVGTNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPT 253
Query: 259 YRWAKGGSPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLF 310
RW K + + R E+ D + V +C N VG A S L V
Sbjct: 254 VRWRKDDGELPKS---RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
Query: 311 G---PILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGS----------- 356
G P KP V +G +F C GNP P + W R G +L S
Sbjct: 311 GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 357 ---GATLRLPSVGPEDAGDYVCRA--EAGLSGLRGGAAEARLTVNAPPVVTALHSAP--- 408
L + +V D G Y+C+ AG + + + PP V + P
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV--IRQGPVNQ 428
Query: 409 -AFLRGPARLQCLVFASPAPDAVVWSWD 435
+ G L C+ SP P ++W D
Sbjct: 429 TVAVDGTFVLSCVATGSPVP-TILWRKD 455
Score = 65.5 bits (158), Expect = 2e-10
Identities = 103/461 (22%), Positives = 161/461 (34%), Gaps = 64/461 (13%)
Query: 26 FLQQPEDLVVLLGEEARLPCA--LGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAAN 83
F Q P D++V +GE A + C G + W K G L + + R I G
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-----RITIRGGK-- 185
Query: 84 GQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPS-VSLVAGVPA 142
L I D Y C T + R +++ L E P + PS +++ A
Sbjct: 186 ----LMITYTRKSDAGKYVCVGTNM-VGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
Query: 143 NLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATF 202
C +RGD P P + W +D DG L K + TL + + D ++
Sbjct: 241 EFKCEARGD--PVPTVRWRKD----DGE-----LPKSRYEIRDDHTLKIRKVTAGDMGSY 289
Query: 203 VCRARSQALPTGRDTAITLSL-QYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRW 261
C A + +T+ + PP + V G V F C+AT P +
Sbjct: 290 TCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWR 349
Query: 262 AKGGSPVLGARGP-----RLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDV 308
+G +L + P R V V C+ N GS L+V
Sbjct: 350 REGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Query: 309 LFGPILQAKPEPV------SVDVGEDASF--SCAWRGNPLPRVTWTRRGG---------A 351
++ +P PV + V D +F SC G+P+P + W + G
Sbjct: 410 T--DVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIK 467
Query: 352 QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFL 411
Q+ +R +G D G Y C A SG +A + PV + P +
Sbjct: 468 QLENGVLQIRYAKLG--DTGRYTCIASTP-SGEATWSAYIEVQEFGVPVQPPRPTDPNLI 524
Query: 412 RGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETF 452
P+ + + V SW + +++E F
Sbjct: 525 --PSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF 563
Score = 58.5 bits (140), Expect = 2e-08
Identities = 74/301 (24%), Positives = 109/301 (36%), Gaps = 46/301 (15%)
Query: 225 YPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVA 280
+PP + S V +GE C+A +P T W KGG V R R+ + +
Sbjct: 27 FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT-IEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 281 DASFLTEPVS------------CEVSNAVGSA-NRSTALDV-LFGPILQAKPEPVSVDVG 326
+ F V C N +G A + + +L+V + + P V V VG
Sbjct: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
Query: 327 EDASFSC-AWRGNPLPRVTWTRRGG------AQVLGSGATLRLPSVGPEDAGDYVCRAEA 379
E A C RG+P P ++W + G ++ G L + DAG YVC
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC-VGT 204
Query: 380 GLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFL 439
+ G R + P V + + A +C P P V W D+G L
Sbjct: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-TVRWRKDDGEL 263
Query: 440 EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQAS 499
P+SR + L I D S+ C A N +G+ A A+
Sbjct: 264 ---------------PKSRYEIRDD--HTLKIRKVTAGDMG-SYTCVAENMVGKAEASAT 305
Query: 500 L 500
L
Sbjct: 306 L 306
Score = 46.2 bits (108), Expect = 1e-04
Identities = 43/150 (28%), Positives = 58/150 (38%), Gaps = 11/150 (7%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGL--ALGGQRDLPGWSRYWISGN 80
PHF+ +P D VV LG C A G + W + G L + SR+ +S
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 374
Query: 81 AANGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHV--LVPPEAPQVLGGPSVSLV 137
DL I V+ D Y CQ AG A L V ++ P V+ V+
Sbjct: 375 G-----DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 138 AGVPANLTCRSRGDARPTPELLWFRDGVLL 167
V P P +LW +DGVL+
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLV 459
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 92.0 bits (227), Expect = 2e-18
Identities = 107/407 (26%), Positives = 157/407 (38%), Gaps = 48/407 (11%)
Query: 126 PQVLGGPSVSLVA-GVPANLTCRSRGDARPTPELLWFRDGVLL----DGATFHQTLLKEG 180
P+++ PS +V+ G PA L C++ G RPTP + W++ G + D H+ LL G
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEG--RPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 181 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYP---PEVTLSASPHT 237
+ + + S D +VC AR+ G + SL+ + + S
Sbjct: 87 SLFFLR--IVHGRKSRPDEGVYVCVARNYL---GEAVSHNASLEVAILRDDFRQNPSDVM 141
Query: 238 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPV------LGARGPRLEVVADASFLTEPVSC 291
V GE + CQ P W K GSP+ + RG +L + C
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 201
Query: 292 EVSNAVGSANRSTA-LDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG 350
+N VG A L VL P +P ++V V + A F C RG+P+P V W + G
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261
Query: 351 -----AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNA------PP 399
+ TL++ V D G Y C AE + G AEA T+ P
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMV-----GKAEASATLTVQVGSEPPH 316
Query: 400 VVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRG 459
V L QC +P P A+ W GSQ L+ ++ P+S
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWR------REGSQN--LLFSYQPPQSSS 367
Query: 460 GLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLL 506
L I+ Q SD + C N G +A L D++
Sbjct: 368 RFSVSQTGDLTITNVQRSDVG-YYICQTLNVAGSIITKAYLEVTDVI 413
Score = 82.8 bits (203), Expect = 1e-15
Identities = 114/448 (25%), Positives = 161/448 (35%), Gaps = 57/448 (12%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P ++ P DL+V GE A L C A G ++W K G + +D P R + +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 83 NGQHDLHIRPVELEDEASYECQATQ--AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVA-G 139
+H R DE Y C A S A L V + + PS +VA G
Sbjct: 89 FFLRIVHGRK-SRPDEGVYVCVARNYLGEAVSHNASLEVAILRD--DFRQNPSDVMVAVG 145
Query: 140 VPANLTCR-SRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDD 198
PA + C+ RG P P + W +DG LD T+ L +T D
Sbjct: 146 EPAVMECQPPRG--HPEPTISWKKDGSPLDDKDERITIR--------GGKLMITYTRKSD 195
Query: 199 GATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTG 258
+VC + + A L++ P S V + F C+A PV
Sbjct: 196 AGKYVCVGTNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPT 253
Query: 259 YRWAKGGSPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLF 310
RW K + + R E+ D + V +C N VG A S L V
Sbjct: 254 VRWRKDDGELPKS---RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
Query: 311 G---PILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGS----------- 356
G P KP V +G +F C GNP P + W R G +L S
Sbjct: 311 GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 357 ---GATLRLPSVGPEDAGDYVCRA--EAGLSGLRGGAAEARLTVNAPPVVTALHSAP--- 408
L + +V D G Y+C+ AG + + + PP V + P
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV--IRQGPVNQ 428
Query: 409 -AFLRGPARLQCLVFASPAPDAVVWSWD 435
+ G L C+ SP P ++W D
Sbjct: 429 TVAVDGTFVLSCVATGSPVP-TILWRKD 455
Score = 65.5 bits (158), Expect = 2e-10
Identities = 103/461 (22%), Positives = 161/461 (34%), Gaps = 64/461 (13%)
Query: 26 FLQQPEDLVVLLGEEARLPCA--LGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAAN 83
F Q P D++V +GE A + C G + W K G L + + R I G
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-----RITIRGGK-- 185
Query: 84 GQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPS-VSLVAGVPA 142
L I D Y C T + R +++ L E P + PS +++ A
Sbjct: 186 ----LMITYTRKSDAGKYVCVGTNM-VGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
Query: 143 NLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATF 202
C +RGD P P + W +D DG L K + TL + + D ++
Sbjct: 241 EFKCEARGD--PVPTVRWRKD----DGE-----LPKSRYEIRDDHTLKIRKVTAGDMGSY 289
Query: 203 VCRARSQALPTGRDTAITLSL-QYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRW 261
C A + +T+ + PP + V G V F C+AT P +
Sbjct: 290 TCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWR 349
Query: 262 AKGGSPVLGARGP-----RLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDV 308
+G +L + P R V V C+ N GS L+V
Sbjct: 350 REGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Query: 309 LFGPILQAKPEPV------SVDVGEDASF--SCAWRGNPLPRVTWTRRGG---------A 351
++ +P PV + V D +F SC G+P+P + W + G
Sbjct: 410 T--DVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIK 467
Query: 352 QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFL 411
Q+ +R +G D G Y C A SG +A + PV + P +
Sbjct: 468 QLENGVLQIRYAKLG--DTGRYTCIASTP-SGEATWSAYIEVQEFGVPVQPPRPTDPNLI 524
Query: 412 RGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETF 452
P+ + + V SW + +++E F
Sbjct: 525 --PSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF 563
Score = 58.5 bits (140), Expect = 2e-08
Identities = 74/301 (24%), Positives = 109/301 (36%), Gaps = 46/301 (15%)
Query: 225 YPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVA 280
+PP + S V +GE C+A +P T W KGG V R R+ + +
Sbjct: 27 FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT-IEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 281 DASFLTEPVS------------CEVSNAVGSA-NRSTALDV-LFGPILQAKPEPVSVDVG 326
+ F V C N +G A + + +L+V + + P V V VG
Sbjct: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
Query: 327 EDASFSC-AWRGNPLPRVTWTRRGG------AQVLGSGATLRLPSVGPEDAGDYVCRAEA 379
E A C RG+P P ++W + G ++ G L + DAG YVC
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC-VGT 204
Query: 380 GLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFL 439
+ G R + P V + + A +C P P V W D+G L
Sbjct: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-TVRWRKDDGEL 263
Query: 440 EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQAS 499
P+SR + L I D S+ C A N +G+ A A+
Sbjct: 264 ---------------PKSRYEIRDD--HTLKIRKVTAGDMG-SYTCVAENMVGKAEASAT 305
Query: 500 L 500
L
Sbjct: 306 L 306
Score = 46.2 bits (108), Expect = 1e-04
Identities = 43/150 (28%), Positives = 58/150 (38%), Gaps = 11/150 (7%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGL--ALGGQRDLPGWSRYWISGN 80
PHF+ +P D VV LG C A G + W + G L + SR+ +S
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 374
Query: 81 AANGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHV--LVPPEAPQVLGGPSVSLV 137
DL I V+ D Y CQ AG A L V ++ P V+ V+
Sbjct: 375 G-----DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 138 AGVPANLTCRSRGDARPTPELLWFRDGVLL 167
V P P +LW +DGVL+
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLV 459
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 90.5 bits (223), Expect = 5e-18
Identities = 137/539 (25%), Positives = 189/539 (35%), Gaps = 81/539 (15%)
Query: 7 PALLVLLFCFRGRAGPS-------------PHFLQQPEDLVVLLGEEARLPC-ALGAYWG 52
P LL++ F G G P ++ P D++V GE L C A G
Sbjct: 17 PGLLMMTVVFWGHQGNGQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTP 76
Query: 53 LVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQ--AGL 110
++W K G + +D P R + + +H R + DE SY C A
Sbjct: 77 TIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSK-PDEGSYVCVARNYLGEA 135
Query: 111 RSRPAQLHV-LVPPEAPQVLGGPSVSLVAGVPANLTCRS-RGDARPTPELLWFRDGVLLD 168
SR A L V L+ + Q V + AG PA L C+ RG P P + W +D V +D
Sbjct: 136 VSRNASLEVALLRDDFRQ--NPTDVVVAAGEPAILECQPPRG--HPEPTIYWKKDKVRID 191
Query: 169 GATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPE 228
KE L ++ D + C + D A L++ P
Sbjct: 192 D--------KEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPA-ELTVFERPT 242
Query: 229 VTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGP-----RLEVVADAS 283
V E E V F CQ P T RW K + + R L + S
Sbjct: 243 FLRRPINQVVLEEEAVEFRCQVQGDPQPT-VRWKKDDADLPRGRYDIKDDYTLRIKKTMS 301
Query: 284 FLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRV 343
C N VG S L V P +P V G +F C +GNP P V
Sbjct: 302 TDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAV 361
Query: 344 TWTRRGGAQVL--------------GSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGA- 388
W + G +L L + ++ DAG Y+C+A + A
Sbjct: 362 FWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQ 421
Query: 389 --AEARLTVNAPPVVTALHSAPA----FLRGPARLQCLVFASPAPDAVVWSW-DEGFLEA 441
LT PP++ PA + G A L+C P P V SW EGF
Sbjct: 422 LEVTDVLTDRPPPIIL---QGPANQTLAVDGTALLKCKATGDPLP---VISWLKEGF--- 472
Query: 442 GSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASL 500
TFP + R + L I + SD + ++ C A + GE A L
Sbjct: 473 ---------TFPGRDPRATIQEQ--GTLQIKNLRISD-TGTYTCVATSSSGETSWSAVL 519
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 90.1 bits (222), Expect = 6e-18
Identities = 101/400 (25%), Positives = 156/400 (39%), Gaps = 57/400 (14%)
Query: 124 EAPQVLGGPS-VSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTP 182
E P++ P + +G TCR+ G+ P PE++W R+ L T + L +
Sbjct: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGN--PKPEIIWLRNNNELSMKTDSRLNLLD--- 298
Query: 183 GSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQY---PPEVTLSASPHTVQ 239
+ TL + D + C A++ A G ++L+Y P T P +
Sbjct: 299 ---DGTLMIQNTQETDQGIYQCMAKNVA---GEVKTQEVTLRYFGSPARPTFVIQPQNTE 352
Query: 240 E--GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPV-------- 289
GE V C AT PP W +G L PR+ + + V
Sbjct: 353 VLVGESVTLECSATGHPPPR-ISWTRGDRTPLPV-DPRVNITPSGGLYIQNVVQGDSGEY 410
Query: 290 SCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG 349
+C +N + S + + + V P P+ V G+ F C +GNP P + WT +G
Sbjct: 411 ACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWT-KG 469
Query: 350 GAQ--------VLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV 401
G+Q VL SG TLR+ V D G Y C+A + G + A + PV
Sbjct: 470 GSQLSVDRRHLVLSSG-TLRISGVALHDQGQYECQA-VNIIGSQKVVAHLTVQPRVTPVF 527
Query: 402 TALHSAPAFLRGP-ARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGG 460
++ S G +L C P P A+ W+ D ++ G+F + +PE
Sbjct: 528 ASIPSDTTVEVGANVQLPCSSQGEPEP-AITWNKDG--VQVTESGKFHI----SPE---- 576
Query: 461 LGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASL 500
L I+ +D R + C ARN +G L
Sbjct: 577 ------GFLTINDVGPADAGR-YECVARNTIGSASVSMVL 609
Score = 61.2 bits (147), Expect = 3e-09
Identities = 59/216 (27%), Positives = 89/216 (41%), Gaps = 30/216 (13%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P F P+D VV+ G+ C A G ++ WTK G L R R+ + +
Sbjct: 433 PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDR------RHLVLSSGT 486
Query: 83 NGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGG-PSVSLV-AGV 140
L I V L D+ YECQA + S+ H+ V P V PS + V G
Sbjct: 487 -----LRISGVALHDQGQYECQAVNI-IGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGA 540
Query: 141 PANLTCRSRGDARPTPELLWFRDGV-LLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDG 199
L C S+G+ P P + W +DGV + + FH S E LT+ D
Sbjct: 541 NVQLPCSSQGE--PEPAITWNKDGVQVTESGKFHI---------SPEGFLTINDVGPADA 589
Query: 200 ATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASP 235
+ C AR+ +++++ P+V+ + P
Sbjct: 590 GRYECVARNTIGSASVSMVLSVNV---PDVSRNGDP 622
Score = 50.1 bits (118), Expect = 7e-06
Identities = 71/295 (24%), Positives = 109/295 (36%), Gaps = 35/295 (11%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P F+ QP++ VL+GE L C A G + WT+ G + LP R I+ +
Sbjct: 342 PTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTR-----GDRTPLPVDPRVNITPSGG 396
Query: 83 NGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLV-AGVP 141
L+I+ V D Y C AT + S A ++V PQ P +V G
Sbjct: 397 -----LYIQNVVQGDSGEYACSATN-NIDSVHATAFIIV-QALPQFTVTPQDRVVIEGQT 449
Query: 142 ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 201
+ C ++G+ P P + W + G L H L TL ++ + D
Sbjct: 450 VDFQCEAKGN--PPPVIAWTKGGSQLSVDRRHLVL--------SSGTLRISGVALHDQGQ 499
Query: 202 FVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRW 261
+ C+A + +T+ + P S TV+ G V C + +P W
Sbjct: 500 YECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPE-PAITW 558
Query: 262 AKGGSPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDV 308
K G V + + + V C N +GSA+ S L V
Sbjct: 559 NKDGVQV--TESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
>gi|13489095 sialoadhesin precursor [Homo sapiens]
Length = 1709
Score = 90.1 bits (222), Expect = 6e-18
Identities = 119/437 (27%), Positives = 177/437 (40%), Gaps = 70/437 (16%)
Query: 95 LEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDAR 153
LE+E Y C+A+ A G S A + +A + PS +L G ANLTC +A
Sbjct: 681 LEEEGLYLCEASNALGNASTSATFN----GQATVLAIAPSHTLQEGTEANLTCNVSREAA 736
Query: 154 PTP-ELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALP 212
+P WFR+GVL G +E T+TL P + D A + CR ++A
Sbjct: 737 GSPANFSWFRNGVLW-------------AQGPLE-TVTLLPVARTDAALYACRILTEA-G 781
Query: 213 TGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT------GYRWAKGGS 266
T + LS+ YPP+ ++ + +G +F+C ++P + A
Sbjct: 782 AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLG 841
Query: 267 PVLGARGPRLEVVADASFLTEPVS-----------CEVSNAVGSANRSTALDVLFGPILQ 315
P + + G R + A+A+ L V CE +N +GS+N S V G +Q
Sbjct: 842 PQVPSHG-RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR-GAWVQ 899
Query: 316 AKPEPVSVDVGEDASFSCAWRGNPLPRVT---WTRRGGAQVLGSGATLRLPSVGPEDAGD 372
P P + G+ SC +P T W R G + ATLR ++ AG
Sbjct: 900 VSPSP-ELQEGQAVVLSCQVHTG-VPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGA 957
Query: 373 YVCRAEAGLSGLRGGAAEARLTVNAPP----VVTALHSAPAFLRGPARLQCLVFASPAP- 427
Y C+A+A S AA L V+ P + T + + P L L C V + P
Sbjct: 958 YHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRL---GLLLCRVDSDPPAQ 1014
Query: 428 ------DAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSR 481
D +V S +G G +G +P + P + L I G D
Sbjct: 1015 LRLLHGDRLVASTLQGV--GGPEG-------SSPRLHVAVAPNTLR-LEIHGAMLED-EG 1063
Query: 482 SFNCSARNRLGEGGAQA 498
+ C A N LG+ A A
Sbjct: 1064 VYICEASNTLGQASASA 1080
Score = 72.4 bits (176), Expect = 1e-12
Identities = 96/400 (24%), Positives = 150/400 (37%), Gaps = 72/400 (18%)
Query: 27 LQQPEDLVVLLGEEARLPCALGAYWGLV---QWTKSGLALGGQRDLPGWSRYWISGNAAN 83
L P +L GE L C + + + V +W K G+ L + +
Sbjct: 244 LLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV-------------- 289
Query: 84 GQHDLHIRPVELEDEASYECQATQA--GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVP 141
LH+ D Y CQA L S P LH+ + +V P+ ++
Sbjct: 290 ----LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA----EVQVSPAGPILENQT 341
Query: 142 ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 201
L C + +A W+++ VLL+ A H TL L + D
Sbjct: 342 VTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH--------------TLRLHLATRADTGF 387
Query: 202 FVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT---- 257
+ C ++ + R +++ + +PP + + Q G I C ++P T
Sbjct: 388 YFCEVQN-VHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLS 446
Query: 258 --GYRWAKGG-----SPVL-GARGP---RLEVVADASFLTEPVSCEVSNAVGSAN----- 301
G+ A SP G GP RLE+ + C +N++G+A
Sbjct: 447 HGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDF 506
Query: 302 RSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLP--RVTWTRRGGAQVLGSGAT 359
+ A +L P + V G+ + SC +P P R +W G G G++
Sbjct: 507 HANAARLLISPAAE-------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSS 559
Query: 360 LRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPP 399
L LP+ DAG Y CRA G S G ++ A LTV PP
Sbjct: 560 LLLPAASSTDAGSYHCRARDGHSA-SGPSSPAVLTVLYPP 598
Score = 56.6 bits (135), Expect = 8e-08
Identities = 115/477 (24%), Positives = 165/477 (34%), Gaps = 67/477 (14%)
Query: 88 LHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCR 147
L +R + L D SY C+AT L S L V QV PS L G L+C+
Sbjct: 861 LEVRELGLGDSGSYRCEATNV-LGSSNTSLFFQVRGAWVQV--SPSPELQEGQAVVLSCQ 917
Query: 148 SRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRAR 207
W+RDG L +T +TL + + C+A+
Sbjct: 918 VHTGVPEGTSYRWYRDGQPLQEST--------------SATLRFAAITLTQAGAYHCQAQ 963
Query: 208 SQ-ALPTGRDTAITLSLQYPP-EVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKG- 264
+ + T I+L + Y P VTL+ T G + LC+ + PP R G
Sbjct: 964 APGSATTSLAAPISLHVSYAPRHVTLTTLMDT-GPGRLGLLLCRVDSDPPAQ-LRLLHGD 1021
Query: 265 ---GSPVLGARG-----PRLEVVADASFLTEPVS-----------CEVSNAVGSANRSTA 305
S + G G PRL V + L + CE SN +G A+ S
Sbjct: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081
Query: 306 LDVLFGPILQAKPEPVSVDVGEDASFSC-AWRGNPLPRVTWTRRGGAQVLGSGATLRLPS 364
D +Q P +V G+ + +C W +P ++T+T Q ++ LP+
Sbjct: 1082 FDAQ-AVNVQVWP-GATVREGQLVNLTCLVWTTHP-AQLTYTWYQDGQQRLDAHSIPLPN 1138
Query: 365 VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFAS 424
V DA Y C G R + P+ + AP LR L+
Sbjct: 1139 VTVRDATSYRC----------GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQL 1188
Query: 425 PAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFN 484
V S L GR L + A P + L + G Q D ++
Sbjct: 1189 ALVLCTVDSRPPAQLALSHAGRLLASSTAASV------PNTLR-LELRGPQPRD-EGFYS 1240
Query: 485 CSARNRLGEGGAQASLG----RRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHS 537
CSAR+ LG+ L R L P + G T L W H+
Sbjct: 1241 CSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297
Score = 48.1 bits (113), Expect = 3e-05
Identities = 111/483 (22%), Positives = 164/483 (33%), Gaps = 71/483 (14%)
Query: 88 LHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 146
L +R + DE Y C A + G + +L + E +V+ P ++ G P +TC
Sbjct: 1226 LELRGPQPRDEGFYSCSARSPLGQANTSLELRL----EGVRVILAPEAAVPEGAPITVTC 1281
Query: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 206
PT W+ +G L+EG S L+ + + C+A
Sbjct: 1282 ADPAAHAPT-LYTWYHNG----------RWLQEGPAAS----LSFLVATRAHAGAYSCQA 1326
Query: 207 RSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT--------- 257
+ A T L + Y P+ + +S + + C ++PP
Sbjct: 1327 Q-DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKV 1385
Query: 258 ------GYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFG 311
+ A G V AR V D + C N +GS + L V G
Sbjct: 1386 LATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-EG 1444
Query: 312 PILQAKPEPVSVDVGEDASFSCAWRGNPLP----RVTW---TRRGGAQVLGSGATLRLPS 364
+ A+P + V G + SC G P P W RR A+ + TL
Sbjct: 1445 ARVVAEP-GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPV---PTLAFTH 1500
Query: 365 VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNA-----PPVVTALHSAPAFLRGPARLQC 419
V AG Y C AE G AA A + + P + LRG L C
Sbjct: 1501 VARAQAGMYHCLAELP----TGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRG--ILDC 1554
Query: 420 LVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPA-PESRGGLGPGLISVLHISGTQESD 478
V + P + + QG PA P P + V I + SD
Sbjct: 1555 RVDSEPLASLTLHLGSRLVASSQPQGA------PAEPHIHVLASPNALRV-DIEALRPSD 1607
Query: 479 FSRSFNCSARNRLGEGGAQASLGRRDL--LPTVRIVAGVAAATTTLLMVITGVALC-CWR 535
+ CSA N LG G R L L + + V LL+++ G+ C WR
Sbjct: 1608 -QGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWR 1666
Query: 536 HSK 538
+
Sbjct: 1667 RRR 1669
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 89.4 bits (220), Expect = 1e-17
Identities = 131/509 (25%), Positives = 181/509 (35%), Gaps = 68/509 (13%)
Query: 24 PHFLQQPEDLVVLLGEEARLPC-ALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAA 82
P ++ P D++V GE L C A G ++W K G + +D P R + +
Sbjct: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
Query: 83 NGQHDLHIRPVELEDEASYECQATQ--AGLRSRPAQLHV-LVPPEAPQVLGGPSVSLVAG 139
+H R + DE SY C A SR A L V L+ + Q V + AG
Sbjct: 91 FFLRIVHGRRSK-PDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQ--NPTDVVVAAG 147
Query: 140 VPANLTCRS-RGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDD 198
PA L C+ RG P P + W +D V +D KE L ++ D
Sbjct: 148 EPAILECQPPRG--HPEPTIYWKKDKVRIDD--------KEERISIRGGKLMISNTRKSD 197
Query: 199 GATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTG 258
+ C + D A L++ P V E E V F CQ P T
Sbjct: 198 AGMYTCVGTNMVGERDSDPA-ELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPT- 255
Query: 259 YRWAKGGSPVLGARGP-----RLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPI 313
RW K + + R L + S C N VG S L V P
Sbjct: 256 VRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQ 315
Query: 314 LQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVL--------------GSGAT 359
+P V G +F C +GNP P V W + G +L
Sbjct: 316 FVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD 375
Query: 360 LRLPSVGPEDAGDYVCRAEAGLSGLRGGA---AEARLTVNAPPVVTALHSAPA----FLR 412
L + ++ DAG Y+C+A + A LT PP++ PA +
Sbjct: 376 LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIIL---QGPANQTLAVD 432
Query: 413 GPARLQCLVFASPAPDAVVWSW-DEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHI 471
G A L+C P P V SW EGF TFP + R + L I
Sbjct: 433 GTALLKCKATGDPLP---VISWLKEGF------------TFPGRDPRATIQEQ--GTLQI 475
Query: 472 SGTQESDFSRSFNCSARNRLGEGGAQASL 500
+ SD + ++ C A + GE A L
Sbjct: 476 KNLRISD-TGTYTCVATSSSGETSWSAVL 503
Score = 49.7 bits (117), Expect = 9e-06
Identities = 75/311 (24%), Positives = 113/311 (36%), Gaps = 66/311 (21%)
Query: 225 YPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVA 280
+PP + S V +GE C+A +P T W K G V R R+ + +
Sbjct: 29 FPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPT-IEWYKDGERVETDKDDPRSHRMLLPS 87
Query: 281 DASFLTEPVS------------CEVSNAVGSA-NRSTALDV-LFGPILQAKPEPVSVDVG 326
+ F V C N +G A +R+ +L+V L + P V V G
Sbjct: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 147
Query: 327 EDASFSC-AWRGNPLPRVTWTR------RGGAQVLGSGATLRLPSVGPEDAGDYVCRAEA 379
E A C RG+P P + W + ++ G L + + DAG Y C
Sbjct: 148 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTC-VGT 206
Query: 380 GLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGP----------ARLQCLVFASPAPDA 429
+ G R ++ P + P FLR P +C V P P
Sbjct: 207 NMVGER----------DSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQP-T 255
Query: 430 VVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARN 489
V W D+ L +GR+ ++ L I T +D ++ C A N
Sbjct: 256 VRWKKDDADL---PRGRYDIKD--------------DYTLRIKKTMSTD-EGTYMCIAEN 297
Query: 490 RLGEGGAQASL 500
R+G+ A A+L
Sbjct: 298 RVGKMEASATL 308
>gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
Length = 814
Score = 86.3 bits (212), Expect = 9e-17
Identities = 118/434 (27%), Positives = 176/434 (40%), Gaps = 76/434 (17%)
Query: 3 RMRVPALLVLLFCFRGRAGPSPH--FLQQPEDLVVLLGEEARLPCAL-GAYWGLVQWTKS 59
R+ +P LL+LL G S F +P D V + G+ L C + G + W K+
Sbjct: 19 RLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKN 78
Query: 60 GLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELE------DEASYECQA-TQAGLR- 111
G+ +LP + + N + L IR LE DE YEC A + GL
Sbjct: 79 GV------ELPESTHSTLLANGS-----LMIRHFRLEPGGSPSDEGDYECVAQNRFGLVV 127
Query: 112 SRPAQLHVLVPPEA---PQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLD 168
SR A++ + PQ G G A C+ G P P + W ++ V +D
Sbjct: 128 SRKARIQAATMSDFHVHPQATVGEE-----GGVARFQCQIHG--LPKPLITWEKNRVPID 180
Query: 169 GATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQA-LPTGRDTAITLS----- 222
TLL +G L +T +DG F C A + A + +T+S
Sbjct: 181 TDNERYTLLPKGV-------LQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSG 233
Query: 223 LQYPPEVTLSASPHTVQEGEKVIFLCQATAQP-PVTGYRWAKGGSPVLGARGPRLE---- 277
P + + T+ + + C AT P P+ W++ +G G ++
Sbjct: 234 AYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVS--WSRLDGRPIGVEGIQVLGTGN 291
Query: 278 -VVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAK------PEPVSVDVGEDAS 330
+++D + V +N G+ R TA L ++QA P+ +S G A
Sbjct: 292 LIISDVTVQHSGVYVCAANRPGTRVRRTAQGRL---VVQAPAEFVQHPQSISRPAGTTAM 348
Query: 331 FSCAWRGNPLPRVTWTRRGGAQVLGSG---------ATLRLPSVGPEDAGDYVCRAEAGL 381
F+C +G P P VTW + G QVLG G +TL + +GPED Y C AE
Sbjct: 349 FTCQAQGEPPPHVTWLKNG--QVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAE--- 403
Query: 382 SGLRGGAAEARLTV 395
+ A ARLTV
Sbjct: 404 NSAGSSQASARLTV 417
Score = 49.3 bits (116), Expect = 1e-05
Identities = 83/322 (25%), Positives = 121/322 (37%), Gaps = 40/322 (12%)
Query: 17 RGRAGPSPHFLQQPEDLVVLLGEEARLPCAL-GAYWGLVQWTKSGLALGGQRDLPGWSRY 75
R +A F P+ V G AR C + G L+ W K+ + + + RY
Sbjct: 132 RIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNE-----RY 186
Query: 76 WISGNAANGQHDLHIRPVELEDEASYECQATQ-AGLR-SRPAQLHVLVPPEA----PQVL 129
+ L I + ED + C A+ A +R S A+L V P +L
Sbjct: 187 TLLPKGV-----LQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAIL 241
Query: 130 GGP-SVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVEST 188
GP +++L A L C + G+ RP + W R LDG + + EG
Sbjct: 242 VGPENLTLTVHQTAVLECVATGNPRPI--VSWSR----LDG----RPIGVEGIQVLGTGN 291
Query: 189 LTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLC 248
L ++ + +VC A R L +Q P E + G +F C
Sbjct: 292 LIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTC 351
Query: 249 QATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLT--------EPV-SCEVSNAVGS 299
QA +PP W K G VLG G + + + S LT E + C N+ GS
Sbjct: 352 QAQGEPP-PHVTWLKNGQ-VLGPGG-HVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGS 408
Query: 300 ANRSTALDVLFGPILQAKPEPV 321
+ S L VL+ L P V
Sbjct: 409 SQASARLTVLWAEGLPGPPRNV 430
>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
[Homo sapiens]
Length = 940
Score = 85.9 bits (211), Expect = 1e-16
Identities = 111/416 (26%), Positives = 152/416 (36%), Gaps = 63/416 (15%)
Query: 5 RVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGA------YWGL----V 54
R+P L VLL G + F++QP L G A L C + A YW L V
Sbjct: 13 RLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPV 72
Query: 55 QWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQA----TQAGL 110
Q T+ A G R L+D +++C A T
Sbjct: 73 QDTERRFAQGSSLSFAAVDR--------------------LQDSGTFQCVARDDVTGEEA 112
Query: 111 RSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGV-LLDG 169
RS A ++ P VL P+ +T R D P P WFRDG L DG
Sbjct: 113 RSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDG 172
Query: 170 ATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSL--QYPP 227
+ H T S E LTL P + + C A S TLS+ +
Sbjct: 173 QSNH-------TVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFA 225
Query: 228 EVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGP----RLEVVADAS 283
V L+ V E+ +F CQ +AQPP + + +P+ P R V A+ S
Sbjct: 226 RVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGS 285
Query: 284 FL---TEPVSCEVSNAVGSANRSTAL---DVLFGPILQAKP--EPVSVDVGEDASFSC-A 334
L P + + +G R + L ++ P EP G + +C
Sbjct: 286 LLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLP 345
Query: 335 WRGNPLPRVTWTRRG-----GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLR 385
+G P P V W G +V G L L ++ DAG Y C A A L+G R
Sbjct: 346 PKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHA-ANLAGQR 400
Score = 44.3 bits (103), Expect = 4e-04
Identities = 84/362 (23%), Positives = 126/362 (34%), Gaps = 70/362 (19%)
Query: 30 PEDLVVLLGEEARLPCALGAYWG-LVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDL 88
P+D+VV EEA C A +QW R P R + ANG L
Sbjct: 231 PQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRR--ATVFANGS--L 286
Query: 89 HIRPVELEDEASYECQATQAGLRSRP----AQLHVLVPPEAPQVLGGPSVSLVAGVPANL 144
+ V + Y C G R P A LH+ + P L P V AG +
Sbjct: 287 LLTQVRPRNAGIYRCIGQ--GQRGPPIILEATLHLAEIEDMP--LFEPRV-FTAGSEERV 341
Query: 145 TCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVC 204
TC P P + W GV L H + ++G L L + D + C
Sbjct: 342 TCLPP-KGLPEPSVWWEHAGVRLPT---HGRVYQKG------HELVLANIAESDAGVYTC 391
Query: 205 RARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKG 264
A + A +D IT++ S+ P V + + + T R G
Sbjct: 392 HAANLAGQRRQDVNITVA-------NGSSLPEWVTDNAGTLHFARVT--------RDDAG 436
Query: 265 GSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVD 324
+ + GP+ ++ A + A+ + F + +PE +V
Sbjct: 437 NYTCIASNGPQGQIRAHVQL------------------TVAVFITF----KVEPERTTVY 474
Query: 325 VGEDASFSCAWRGNPLPRVTW---------TRRGGAQVLGSGATLRLPSVGPEDAGDYVC 375
G A C +G+P P + W T+ G + +L + V PED+G Y C
Sbjct: 475 QGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTC 534
Query: 376 RA 377
A
Sbjct: 535 IA 536
>gi|11225258 myelin associated glycoprotein isoform a precursor
[Homo sapiens]
Length = 626
Score = 85.1 bits (209), Expect = 2e-16
Identities = 122/467 (26%), Positives = 179/467 (38%), Gaps = 44/467 (9%)
Query: 118 HVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLL 177
+++VPPE V+ G V + VP N PEL W L + A +
Sbjct: 142 NIVVPPE---VVAGTEVEVSCMVPDNCP-------ELRPELSWLGHEGLGEPAVLGRLRE 191
Query: 178 KEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT 237
EGT V S L P +G C+A + ++ ++YPP + S
Sbjct: 192 DEGTWVQV-SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
Query: 238 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEP--VSCEVSN 295
EG V LC A + PP W + G+ + A L + + E +C N
Sbjct: 251 AIEGSHVSLLCGADSNPPPL-LTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAEN 309
Query: 296 AVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG---GAQ 352
A G NR+ L V++ P + GE S C+ + NP P +T +
Sbjct: 310 AYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTV 369
Query: 353 VLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR 412
+ S L LP+V PED G+Y C AE G R A L+V PV+ L S A R
Sbjct: 370 IYESELQLELPAVSPEDDGEYWCVAE-NQYGQR--ATAFNLSVEFAPVL-LLESHCAAAR 425
Query: 413 GPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHIS 472
+ C+V ++P P S+ F+ R GL L S+L +
Sbjct: 426 DTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVY------SERSGL--VLTSILTLR 477
Query: 473 GTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALC 532
G ++ C+ARN G + L +I G A ++I A+
Sbjct: 478 G--QAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKI--GPVGAVVAFAILI---AIV 530
Query: 533 CW-------RHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSR 572
C+ ++ S SFS N + SSD S PE+ E+ R
Sbjct: 531 CYITQTRRKKNVTESPSFSAGDN-PPVLFSSDFRISGAPEKYESERR 576
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,622,469
Number of Sequences: 37866
Number of extensions: 1993346
Number of successful extensions: 11750
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 162
Number of HSP's successfully gapped in prelim test: 353
Number of HSP's that attempted gapping in prelim test: 7999
Number of HSP's gapped (non-prelim): 2507
length of query: 708
length of database: 18,247,518
effective HSP length: 109
effective length of query: 599
effective length of database: 14,120,124
effective search space: 8457954276
effective search space used: 8457954276
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.