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Search of human proteins with 10947118
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
(1100 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 2276 0.0
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 2056 0.0
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 622 e-178
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 612 e-175
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 590 e-168
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 555 e-157
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 555 e-157
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 555 e-157
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 297 4e-80
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 297 4e-80
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 291 2e-78
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 291 2e-78
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 283 8e-76
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 230 5e-60
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 228 2e-59
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 201 4e-51
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 199 2e-50
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 101 3e-21
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 101 3e-21
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 101 3e-21
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 93 1e-18
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 91 6e-18
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 88 5e-17
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 87 1e-16
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 87 1e-16
gi|11321634 CD2-associated protein [Homo sapiens] 83 1e-15
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 83 2e-15
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 82 2e-15
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 81 5e-15
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 81 5e-15
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 2276 bits (5899), Expect = 0.0
Identities = 1100/1100 (100%), Positives = 1100/1100 (100%)
Query: 1 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 60
MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE
Sbjct: 1 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 60
Query: 61 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 120
EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT
Sbjct: 61 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 120
Query: 121 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 180
PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL
Sbjct: 121 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 180
Query: 181 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSL 240
RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSL
Sbjct: 181 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSL 240
Query: 241 ERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP 300
ERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP
Sbjct: 241 ERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP 300
Query: 301 SSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGWQM 360
SSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGWQM
Sbjct: 301 SSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGWQM 360
Query: 361 ARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESCPM 420
ARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESCPM
Sbjct: 361 ARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESCPM 420
Query: 421 AWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQY 480
AWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQY
Sbjct: 421 AWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQY 480
Query: 481 ESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQ 540
ESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQ
Sbjct: 481 ESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQ 540
Query: 541 NGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDSDQ 600
NGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDSDQ
Sbjct: 541 NGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDSDQ 600
Query: 601 DGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCKGR 660
DGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCKGR
Sbjct: 601 DGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCKGR 660
Query: 661 CPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQTEK 720
CPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQTEK
Sbjct: 661 CPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQTEK 720
Query: 721 AKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRALRR 780
AKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRALRR
Sbjct: 721 AKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRALRR 780
Query: 781 SPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESPR 840
SPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESPR
Sbjct: 781 SPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESPR 840
Query: 841 SYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNW 900
SYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNW
Sbjct: 841 SYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNW 900
Query: 901 YEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLR 960
YEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLR
Sbjct: 901 YEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLR 960
Query: 961 KGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDR 1020
KGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDR
Sbjct: 961 KGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDR 1020
Query: 1021 IHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFV 1080
IHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFV
Sbjct: 1021 IHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFV 1080
Query: 1081 GTSRRTKFFGTFPGNYVKRL 1100
GTSRRTKFFGTFPGNYVKRL
Sbjct: 1081 GTSRRTKFFGTFPGNYVKRL 1100
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 2056 bits (5326), Expect = 0.0
Identities = 996/1011 (98%), Positives = 996/1011 (98%), Gaps = 15/1011 (1%)
Query: 90 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 149
TVDRPKDWYKTMFKQIHMVHKP GLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 9 TVDRPKDWYKTMFKQIHMVHKP---------------GLYNPPYSAQSHPAAKTQTYRPL 53
Query: 150 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 209
SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP
Sbjct: 54 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 113
Query: 210 RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL 269
RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL
Sbjct: 114 RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL 173
Query: 270 GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLNGNPS 329
GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLNGNPS
Sbjct: 174 GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLNGNPS 233
Query: 330 SELDYCSTYRQHLDVPRDSPRAISFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLN 389
SELDYCSTYRQHLDVPRDSPRAISFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLN
Sbjct: 234 SELDYCSTYRQHLDVPRDSPRAISFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLN 293
Query: 390 DDCDSFPDPKVKSESMGSLLCEEDSKESCPMAWGSPYVPEVRSNGRSRIRHRSARNAPGF 449
DDCDSFPDPKVKSESMGSLLCEEDSKESCPMAWGSPYVPEVRSNGRSRIRHRSARNAPGF
Sbjct: 294 DDCDSFPDPKVKSESMGSLLCEEDSKESCPMAWGSPYVPEVRSNGRSRIRHRSARNAPGF 353
Query: 450 LKMYKKMHRINRKDLMNSEVICSVKSRILQYESEQQHKDLLRAWSQCSTEEVPRDMVPTR 509
LKMYKKMHRINRKDLMNSEVICSVKSRILQYESEQQHKDLLRAWSQCSTEEVPRDMVPTR
Sbjct: 354 LKMYKKMHRINRKDLMNSEVICSVKSRILQYESEQQHKDLLRAWSQCSTEEVPRDMVPTR 413
Query: 510 ISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRR 569
ISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRR
Sbjct: 414 ISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRR 473
Query: 570 GCQSNALVPIHIEVTSDEQPRAHVEFSDSDQDGVVSDHSDYIHLEGSSFCSESDFDHFSF 629
GCQSNALVPIHIEVTSDEQPRAHVEFSDSDQDGVVSDHSDYIHLEGSSFCSESDFDHFSF
Sbjct: 474 GCQSNALVPIHIEVTSDEQPRAHVEFSDSDQDGVVSDHSDYIHLEGSSFCSESDFDHFSF 533
Query: 630 TSSESFYGSSHHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERARHENTEEPRRQE 689
TSSESFYGSSHHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERARHENTEEPRRQE
Sbjct: 534 TSSESFYGSSHHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERARHENTEEPRRQE 593
Query: 690 MDPGLSKLAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRG 749
MDPGLSKLAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRG
Sbjct: 594 MDPGLSKLAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRG 653
Query: 750 SLPDNSILHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRMP 809
SLPDNSILHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRMP
Sbjct: 654 SLPDNSILHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRMP 713
Query: 810 RSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK 869
RSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK
Sbjct: 714 RSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK 773
Query: 870 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 929
AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA
Sbjct: 774 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 833
Query: 930 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIF 989
RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIF
Sbjct: 834 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIF 893
Query: 990 PVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQAL 1049
PVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQAL
Sbjct: 894 PVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQAL 953
Query: 1050 YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 954 YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 622 bits (1605), Expect = e-178
Identities = 319/383 (83%), Positives = 327/383 (85%), Gaps = 30/383 (7%)
Query: 1 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 60
MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE
Sbjct: 70 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 129
Query: 61 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 120
EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT
Sbjct: 130 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 189
Query: 121 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 180
PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL
Sbjct: 190 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 249
Query: 181 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP------------ 228
RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP
Sbjct: 250 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPKKPLDYVQDH 309
Query: 229 -------ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGR 281
ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGR
Sbjct: 310 SSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGR 369
Query: 282 VDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLN------GNPSSE-LDY 334
VDLPGSSTTLTKSFTSSSPSSPSRAK + + S + G + G P E L
Sbjct: 370 VDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA 429
Query: 335 CSTYRQHLDVPRDSPRAISFKNG 357
+ Y D + + +SFK G
Sbjct: 430 KAVY----DFKAQTSKELSFKKG 448
Score = 555 bits (1431), Expect = e-158
Identities = 295/398 (74%), Positives = 315/398 (79%), Gaps = 13/398 (3%)
Query: 708 RKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPD 767
RK S P+ E K+S+ + K D ++ + G + S+ I L +
Sbjct: 272 RKFRSEPRSIFEYEPGKSSILQHERPPPKKPLDYVQ-DHSSGVFNEASLYQSSIDRSL-E 329
Query: 768 VPERNSSL----RALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANS 822
P ++S+ R R+S P P L A P + D +P S++ +S
Sbjct: 330 RPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSS 386
Query: 823 SCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 882
S R +DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL
Sbjct: 387 SPSSPSRA---KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 443
Query: 883 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 942
SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE
Sbjct: 444 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 503
Query: 943 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 1002
AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK
Sbjct: 504 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 563
Query: 1003 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 1062
GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL
Sbjct: 564 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 623
Query: 1063 RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 624 RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 612 bits (1577), Expect = e-175
Identities = 319/411 (77%), Positives = 327/411 (79%), Gaps = 58/411 (14%)
Query: 1 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 60
MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE
Sbjct: 47 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 106
Query: 61 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 120
EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT
Sbjct: 107 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 166
Query: 121 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 180
PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL
Sbjct: 167 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 226
Query: 181 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP------------ 228
RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP
Sbjct: 227 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPTDRINPDDIDLE 286
Query: 229 -----------------------------------ASLYQSSIDRSLERPMSSASMASDF 253
ASLYQSSIDRSLERPMSSASMASDF
Sbjct: 287 NEPWYKFFSELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDF 346
Query: 254 RKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSK 313
RKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK + +
Sbjct: 347 RKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR 406
Query: 314 ICPSLCSYSGLN------GNPSSE-LDYCSTYRQHLDVPRDSPRAISFKNG 357
S + G + G P E L + Y D + + +SFK G
Sbjct: 407 SYSSTLTDMGRSAPRERRGTPEKEKLPAKAVY----DFKAQTSKELSFKKG 453
Score = 555 bits (1429), Expect = e-157
Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)
Query: 773 SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 831
S R R+S P P L A P + D +P S++ +SS R
Sbjct: 344 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 399
Query: 832 ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 891
+DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 400 --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 457
Query: 892 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 951
ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 458 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 517
Query: 952 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 1011
DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 518 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 577
Query: 1012 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 1071
IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 578 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 637
Query: 1072 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 638 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 590 bits (1521), Expect = e-168
Identities = 304/364 (83%), Positives = 312/364 (85%), Gaps = 26/364 (7%)
Query: 1 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 60
MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE
Sbjct: 87 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 146
Query: 61 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 120
EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP
Sbjct: 147 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP--------- 197
Query: 121 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 180
GLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL
Sbjct: 198 ------GLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 251
Query: 181 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSL 240
RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSL
Sbjct: 252 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSL 311
Query: 241 ERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP 300
ERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP
Sbjct: 312 ERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP 371
Query: 301 SSPSRAKGGDDSKICPSLCSYSGLN------GNPSSE-LDYCSTYRQHLDVPRDSPRAIS 353
SSPSRAK + + S + G + G P E L + Y D + + +S
Sbjct: 372 SSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVY----DFKAQTSKELS 427
Query: 354 FKNG 357
FK G
Sbjct: 428 FKKG 431
Score = 555 bits (1429), Expect = e-157
Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)
Query: 773 SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 831
S R R+S P P L A P + D +P S++ +SS R
Sbjct: 322 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 377
Query: 832 ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 891
+DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 378 --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 435
Query: 892 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 951
ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 436 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 495
Query: 952 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 1011
DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 496 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 555
Query: 1012 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 1071
IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 556 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 615
Query: 1072 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 616 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 555 bits (1429), Expect = e-157
Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)
Query: 773 SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 831
S R R+S P P L A P + D +P S++ +SS R
Sbjct: 170 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 225
Query: 832 ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 891
+DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 226 --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 283
Query: 892 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 951
ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 284 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 343
Query: 952 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 1011
DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 344 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 403
Query: 1012 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 1071
IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 404 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 463
Query: 1072 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 464 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
Score = 457 bits (1176), Expect = e-128
Identities = 230/275 (83%), Positives = 238/275 (86%), Gaps = 11/275 (4%)
Query: 90 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 149
TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 9 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 68
Query: 150 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 209
SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP
Sbjct: 69 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 128
Query: 210 RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL 269
RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL
Sbjct: 129 RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL 188
Query: 270 GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLN---- 325
GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK + + S + G +
Sbjct: 189 GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRE 248
Query: 326 --GNPSSE-LDYCSTYRQHLDVPRDSPRAISFKNG 357
G P E L + Y D + + +SFK G
Sbjct: 249 RRGTPEKEKLPAKAVY----DFKAQTSKELSFKKG 279
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 555 bits (1429), Expect = e-157
Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)
Query: 773 SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 831
S R R+S P P L A P + D +P S++ +SS R
Sbjct: 502 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 557
Query: 832 ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 891
+DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 558 --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 615
Query: 892 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 951
ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 616 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 675
Query: 952 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 1011
DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 676 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 735
Query: 1012 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 1071
IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 736 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 795
Query: 1072 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 796 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
Score = 503 bits (1294), Expect = e-142
Identities = 287/436 (65%), Positives = 300/436 (68%), Gaps = 83/436 (19%)
Query: 1 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 60
MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE
Sbjct: 180 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 239
Query: 61 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 120
EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT
Sbjct: 240 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 299
Query: 121 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPV--- 177
PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPV
Sbjct: 300 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 359
Query: 178 --------------PPLRPRD-----------------RSSTEKHDWDPPDRKVDT---- 202
PP R D +SS +H+ PP T
Sbjct: 360 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTPTPVPR 419
Query: 203 ---RKFRSE-------------PRSIFEYEPGKSSILQHERP------------------ 228
RK S PRS ++ L RP
Sbjct: 420 EPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNE 479
Query: 229 ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSS 288
ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSS
Sbjct: 480 ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSS 539
Query: 289 TTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLN------GNPSSE-LDYCSTYRQH 341
TTLTKSFTSSSPSSPSRAK + + S + G + G P E L + Y
Sbjct: 540 TTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVY--- 596
Query: 342 LDVPRDSPRAISFKNG 357
D + + +SFK G
Sbjct: 597 -DFKAQTSKELSFKKG 611
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 555 bits (1429), Expect = e-157
Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)
Query: 773 SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 831
S R R+S P P L A P + D +P S++ +SS R
Sbjct: 409 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 464
Query: 832 ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 891
+DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 465 --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 522
Query: 892 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 951
ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 523 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 582
Query: 952 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 1011
DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 583 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 642
Query: 1012 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 1071
IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 643 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 702
Query: 1072 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 703 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
Score = 503 bits (1294), Expect = e-142
Identities = 287/436 (65%), Positives = 300/436 (68%), Gaps = 83/436 (19%)
Query: 1 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 60
MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE
Sbjct: 87 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 146
Query: 61 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 120
EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT
Sbjct: 147 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 206
Query: 121 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPV--- 177
PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPV
Sbjct: 207 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 266
Query: 178 --------------PPLRPRD-----------------RSSTEKHDWDPPDRKVDT---- 202
PP R D +SS +H+ PP T
Sbjct: 267 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTPTPVPR 326
Query: 203 ---RKFRSE-------------PRSIFEYEPGKSSILQHERP------------------ 228
RK S PRS ++ L RP
Sbjct: 327 EPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNE 386
Query: 229 ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSS 288
ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSS
Sbjct: 387 ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSS 446
Query: 289 TTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLN------GNPSSE-LDYCSTYRQH 341
TTLTKSFTSSSPSSPSRAK + + S + G + G P E L + Y
Sbjct: 447 TTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVY--- 503
Query: 342 LDVPRDSPRAISFKNG 357
D + + +SFK G
Sbjct: 504 -DFKAQTSKELSFKKG 518
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 297 bits (760), Expect = 4e-80
Identities = 156/271 (57%), Positives = 191/271 (70%), Gaps = 7/271 (2%)
Query: 834 QDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYI 892
+D ESPR + D S RR +KE PA+A +DFKAQT KEL +KGD VYI
Sbjct: 547 KDSESPRHFIPA--DYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYI 604
Query: 893 LRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNAD 952
++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN D
Sbjct: 605 YKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGD 663
Query: 953 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPP 1011
T VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P
Sbjct: 664 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLP 723
Query: 1012 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVID 1069
S S S + Q+ T + Q + F QALY+Y P+N+DELELR+ D++D
Sbjct: 724 FSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVD 783
Query: 1070 VMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
VMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 784 VMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
Score = 121 bits (303), Expect = 4e-27
Identities = 87/253 (34%), Positives = 141/253 (55%), Gaps = 31/253 (12%)
Query: 56 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 115
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 326 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 379
Query: 116 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 175
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 380 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 429
Query: 176 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSS 235
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ +S +
Sbjct: 430 ---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPT 480
Query: 236 IDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQS---ASRTSPGRVDLPGSSTTL 291
+ S E P +S+F +R+S+ A G L ++ S G + L G S
Sbjct: 481 PEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLK 538
Query: 292 TKSFTSSSPSSPS 304
S ++S+ S S
Sbjct: 539 RPSSSASTKDSES 551
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 297 bits (760), Expect = 4e-80
Identities = 156/271 (57%), Positives = 191/271 (70%), Gaps = 7/271 (2%)
Query: 834 QDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYI 892
+D ESPR + D S RR +KE PA+A +DFKAQT KEL +KGD VYI
Sbjct: 415 KDSESPRHFIPA--DYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYI 472
Query: 893 LRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNAD 952
++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN D
Sbjct: 473 YKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGD 531
Query: 953 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPP 1011
T VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P
Sbjct: 532 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLP 591
Query: 1012 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVID 1069
S S S + Q+ T + Q + F QALY+Y P+N+DELELR+ D++D
Sbjct: 592 FSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVD 651
Query: 1070 VMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
VMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 652 VMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
Score = 121 bits (303), Expect = 4e-27
Identities = 87/253 (34%), Positives = 141/253 (55%), Gaps = 31/253 (12%)
Query: 56 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 115
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 194 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 247
Query: 116 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 175
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 248 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 297
Query: 176 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSS 235
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ +S +
Sbjct: 298 ---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPT 348
Query: 236 IDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQS---ASRTSPGRVDLPGSSTTL 291
+ S E P +S+F +R+S+ A G L ++ S G + L G S
Sbjct: 349 PEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLK 406
Query: 292 TKSFTSSSPSSPS 304
S ++S+ S S
Sbjct: 407 RPSSSASTKDSES 419
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 291 bits (746), Expect = 2e-78
Identities = 146/240 (60%), Positives = 178/240 (74%), Gaps = 4/240 (1%)
Query: 864 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 923
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 500 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 559
Query: 924 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 983
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 560 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 618
Query: 984 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 1042
+RQGIFP++YV+V+K+ K DY D P S S S + Q+ T + Q
Sbjct: 619 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTS 678
Query: 1043 GEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
+ F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 679 QDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
Score = 121 bits (303), Expect = 4e-27
Identities = 87/253 (34%), Positives = 141/253 (55%), Gaps = 31/253 (12%)
Query: 56 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 115
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 194 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 247
Query: 116 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 175
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 248 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 297
Query: 176 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSS 235
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ +S +
Sbjct: 298 ---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPT 348
Query: 236 IDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQS---ASRTSPGRVDLPGSSTTL 291
+ S E P +S+F +R+S+ A G L ++ S G + L G S
Sbjct: 349 PEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLK 406
Query: 292 TKSFTSSSPSSPS 304
S ++S+ S S
Sbjct: 407 RPSSSASTKDSES 419
Score = 83.2 bits (204), Expect = 1e-15
Identities = 54/188 (28%), Positives = 88/188 (46%), Gaps = 31/188 (16%)
Query: 839 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 898
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 549 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 608
Query: 899 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPPP----- 934
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 609 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQR 668
Query: 935 -------AQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 987
++ A Y++ + EL LR GD V ++++ D W+ G T + G
Sbjct: 669 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG 728
Query: 988 IFPVSYVE 995
FP +YV+
Sbjct: 729 TFPGNYVK 736
Score = 40.0 bits (92), Expect = 0.012
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 7/73 (9%)
Query: 855 RERRGTPEKEKLPA-----KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHG 907
++RR TP++ + +A+Y + Q EL + GD V ++ K D W+ G
Sbjct: 666 QQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTK 725
Query: 908 RVGIFPISYVEKL 920
+ G FP +YV+ L
Sbjct: 726 QFGTFPGNYVKPL 738
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 291 bits (746), Expect = 2e-78
Identities = 146/240 (60%), Positives = 178/240 (74%), Gaps = 4/240 (1%)
Query: 864 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 923
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 541 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 600
Query: 924 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 983
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 601 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 659
Query: 984 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 1042
+RQGIFP++YV+V+K+ K DY D P S S S + Q+ T + Q
Sbjct: 660 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTS 719
Query: 1043 GEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
+ F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 720 QDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
Score = 121 bits (303), Expect = 4e-27
Identities = 87/253 (34%), Positives = 141/253 (55%), Gaps = 31/253 (12%)
Query: 56 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 115
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 235 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 288
Query: 116 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 175
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 289 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 338
Query: 176 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSS 235
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ +S +
Sbjct: 339 ---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPT 389
Query: 236 IDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQS---ASRTSPGRVDLPGSSTTL 291
+ S E P +S+F +R+S+ A G L ++ S G + L G S
Sbjct: 390 PEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLK 447
Query: 292 TKSFTSSSPSSPS 304
S ++S+ S S
Sbjct: 448 RPSSSASTKDSES 460
Score = 83.2 bits (204), Expect = 1e-15
Identities = 54/188 (28%), Positives = 88/188 (46%), Gaps = 31/188 (16%)
Query: 839 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 898
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 590 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 649
Query: 899 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPPP----- 934
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 650 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQR 709
Query: 935 -------AQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 987
++ A Y++ + EL LR GD V ++++ D W+ G T + G
Sbjct: 710 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG 769
Query: 988 IFPVSYVE 995
FP +YV+
Sbjct: 770 TFPGNYVK 777
Score = 40.0 bits (92), Expect = 0.012
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 7/73 (9%)
Query: 855 RERRGTPEKEKLPA-----KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHG 907
++RR TP++ + +A+Y + Q EL + GD V ++ K D W+ G
Sbjct: 707 QQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTK 766
Query: 908 RVGIFPISYVEKL 920
+ G FP +YV+ L
Sbjct: 767 QFGTFPGNYVKPL 779
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 283 bits (723), Expect = 8e-76
Identities = 148/260 (56%), Positives = 181/260 (69%), Gaps = 24/260 (9%)
Query: 864 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 923
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 645 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 704
Query: 924 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 983
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 705 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 763
Query: 984 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRI-------HSLSSN-------- 1027
+RQGIFP++YV+V+K+ K DY D P S S HSL +
Sbjct: 764 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEK 823
Query: 1028 -----KPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFV 1080
+ Q+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFV
Sbjct: 824 SYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 883
Query: 1081 GTSRRTKFFGTFPGNYVKRL 1100
GTSRRTK FGTFPGNYVK L
Sbjct: 884 GTSRRTKQFGTFPGNYVKPL 903
Score = 114 bits (285), Expect = 5e-25
Identities = 67/172 (38%), Positives = 107/172 (62%), Gaps = 25/172 (14%)
Query: 56 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 115
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 289 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 342
Query: 116 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 175
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 343 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 392
Query: 176 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER 227
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 393 ---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEK 435
Score = 75.5 bits (184), Expect = 3e-13
Identities = 56/208 (26%), Positives = 90/208 (43%), Gaps = 51/208 (24%)
Query: 839 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 898
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 694 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 753
Query: 899 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARP-------- 931
NWYEG G R GIFPI+YV+ + + P ++ A P
Sbjct: 754 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLR 813
Query: 932 -------------PPPAQ-----------PGEIGEAIAKYNFNADTNVELSLRKGDRVIL 967
P AQ ++ A Y++ + EL LR GD V +
Sbjct: 814 AGPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 873
Query: 968 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 995
+++ D W+ G T + G FP +YV+
Sbjct: 874 MEKCDDGWFVGTSRRTKQFGTFPGNYVK 901
Score = 44.3 bits (103), Expect = 6e-04
Identities = 37/140 (26%), Positives = 56/140 (40%), Gaps = 6/140 (4%)
Query: 785 QPLHPLPPDGAIHCPPYQN--DCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESPRSY 842
Q + P+ I P +N D +P S+S TA+ H ES +SY
Sbjct: 766 QGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSY 825
Query: 843 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 902
R P R ++ +A+Y + Q EL + GD V ++ K D W+
Sbjct: 826 VQPQAQQRRVTPD--RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 883
Query: 903 G--EHHGRVGIFPISYVEKL 920
G + G FP +YV+ L
Sbjct: 884 GTSRRTKQFGTFPGNYVKPL 903
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 230 bits (587), Expect = 5e-60
Identities = 147/410 (35%), Positives = 205/410 (50%), Gaps = 65/410 (15%)
Query: 747 KRGSLPDNSILHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCG 806
++ S P +L R ++EL ++ + ++ SP P P+ P
Sbjct: 265 EKPSQPIEVLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSS 324
Query: 807 RMPRSASFQDVDTANSSCHHQDRGGA----LQDRESPRSYSSTLTDMGRSAPRERRGTPE 862
P + + S H GG+ +D P S G +P R E
Sbjct: 325 SYPHAPYLGSARSL--SPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARRE---E 379
Query: 863 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 922
K++ A+ +DF+AQ+ KEL+ +KGD VYI +++D+NW EGEHHGR+GIFP +YVE L
Sbjct: 380 KKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPA 439
Query: 923 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 982
E +P + PP Q E GEA+A+Y F D VELS RKG+ + L+++V++NWYEG+I G
Sbjct: 440 DEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITG 498
Query: 983 TNRQGIFPVSYVEVVK-----------------KNTKGAEDYPDPPIPHSYSS--DRIHS 1023
T RQGIFP SYV+V + + T A P P + S D I
Sbjct: 499 TGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDL 558
Query: 1024 LSSNKPQRPVFTH---------ENIQGGG---------------------------EPFQ 1047
P+R F+ +N+ G P++
Sbjct: 559 GGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYR 618
Query: 1048 ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 1097
A+Y Y P+NEDELELRE D +DVM++CDDGWFVG SRRT+ FGTFPGNYV
Sbjct: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
Score = 69.7 bits (169), Expect = 1e-11
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 916 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 975
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 358 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 417
Query: 976 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 1035
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 418 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 452
Query: 1036 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 1095
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 453 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 508
Query: 1096 YVK 1098
YV+
Sbjct: 509 YVQ 511
Score = 68.6 bits (166), Expect = 3e-11
Identities = 77/293 (26%), Positives = 122/293 (41%), Gaps = 41/293 (13%)
Query: 39 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY 98
QH Q+ T + S +KR Y GIGPVDESG+P A R++VDRP+DWY
Sbjct: 98 QHTQNWSATWTKD-----SKRRDKRWV-----KYEGIGPVDESGMPIAPRSSVDRPRDWY 147
Query: 99 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPY-SAQSHPAAK---TQTYRPLSKSHS 154
+ MF+QIH PD D +T+ +P + AQ PA + + S HS
Sbjct: 148 RRMFQQIHR-KMPDLQLD-----WTFEEPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHS 201
Query: 155 DNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSST--EKHDWDPPDRKVDTRKFRSEPRSI 212
+ P + + + P LR R++ + W+ ++++T + P+
Sbjct: 202 EELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQ---RPKKP 258
Query: 213 FEYEPGKSSI----LQHERPASLYQSSID---RSLERPMSSASMASDFRKRRKSEPAVGP 265
+PG+ + ER + + +D R++E + S + R+ + P GP
Sbjct: 259 LVDDPGEKPSQPIEVLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGP 318
Query: 266 PRGLGDQ--------SASRTSPGRVDLPGSSTTLTKSFT-SSSPSSPSRAKGG 309
SA SP ++ GS + F SS PS + GG
Sbjct: 319 ASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGG 371
Score = 42.4 bits (98), Expect = 0.002
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 945 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 997
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 228 bits (581), Expect = 2e-59
Identities = 130/314 (41%), Positives = 173/314 (55%), Gaps = 59/314 (18%)
Query: 839 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 898
P S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI +++D+
Sbjct: 17 PSSTRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDK 73
Query: 899 NWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELS 958
NW EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D VELS
Sbjct: 74 NWLEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELS 132
Query: 959 LRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK-----------------KNT 1001
RKG+ + L+++V++NWYEG+I GT RQGIFP SYV+V + + T
Sbjct: 133 FRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLT 192
Query: 1002 KGAEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG------- 1043
A P P + S D I P+R F+ +N+ G
Sbjct: 193 AAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSR 252
Query: 1044 --------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTS 1083
P++A+Y Y P+NEDELELRE D +DVM++CDDGWFVG S
Sbjct: 253 GPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVS 312
Query: 1084 RRTKFFGTFPGNYV 1097
RRT+ FGTFPGNYV
Sbjct: 313 RRTQKFGTFPGNYV 326
Score = 69.7 bits (169), Expect = 1e-11
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 916 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 975
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 16 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 75
Query: 976 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 1035
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 76 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 110
Query: 1036 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 1095
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 111 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 166
Query: 1096 YVK 1098
YV+
Sbjct: 167 YVQ 169
Score = 45.1 bits (105), Expect = 4e-04
Identities = 43/159 (27%), Positives = 66/159 (41%), Gaps = 23/159 (14%)
Query: 765 LPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRM--PRSA--SFQDVDTA 820
LP P ++ R+ R HP P A+ P D G PR SF +
Sbjct: 185 LPTSPRLTAAARSAR--------HPSSPS-ALRSPADPIDLGGQTSPRRTGFSFPTQEPR 235
Query: 821 NSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSK 880
+ + G AL P S D+G S+P T + P +A+Y ++ Q
Sbjct: 236 PQTQNLGTPGPALSHSRGP----SHPLDLGTSSPN----TSQIHWTPYRAMYQYRPQNED 287
Query: 881 ELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYV 917
EL ++GD V ++++ D W+ G + G FP +YV
Sbjct: 288 ELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
Score = 42.4 bits (98), Expect = 0.002
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 945 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 997
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 201 bits (510), Expect = 4e-51
Identities = 101/182 (55%), Positives = 128/182 (70%), Gaps = 2/182 (1%)
Query: 864 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 923
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 816 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 875
Query: 924 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 983
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 876 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 934
Query: 984 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 1042
+RQGIFP++YV+V+K+ K DY D P S S S + + + + +G
Sbjct: 935 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGA 994
Query: 1043 GE 1044
GE
Sbjct: 995 GE 996
Score = 148 bits (373), Expect = 3e-35
Identities = 105/298 (35%), Positives = 146/298 (48%), Gaps = 49/298 (16%)
Query: 839 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 898
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 865 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 924
Query: 899 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPP------ 933
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 925 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
Query: 934 ---------PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 984
+ G G I+K + ++V L R+ D N E PG
Sbjct: 985 QYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLS-----DLNTPEESRPGKP 1039
Query: 985 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 1044
FP S E +++ G + ++ R S QR V T + Q +
Sbjct: 1040 LGSAFPGSEAEQTERHRGGEQ-------AGRKAARRGGSQQPQAQQRRV-TPDRSQTSQD 1091
Query: 1045 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1092 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
Score = 94.0 bits (232), Expect = 7e-19
Identities = 68/220 (30%), Positives = 105/220 (47%), Gaps = 53/220 (24%)
Query: 56 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 115
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ +
Sbjct: 358 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEE 412
Query: 116 DMYNTPY--------------TYNAGLYNPPYSA--------------QSHPAAKTQTYR 147
+ Y Y T + + +P S+P
Sbjct: 413 NPYFPTYKFPELPEIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVA 472
Query: 148 PLSKSHSD-NSP--NAFKDASSPVPPPH-----------------VPPPVPPLRPRDRSS 187
+ SD SP + +D SP+ P P+P +SS
Sbjct: 473 GTADDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSS 532
Query: 188 TEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER 227
+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 533 SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEK 572
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 15/119 (12%)
Query: 809 PRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA 868
P ++F + + H RGG R++ R S + ++RR TP++ +
Sbjct: 1039 PLGSAFPGSEAEQTERH---RGGEQAGRKAARRGGSQ-----QPQAQQRRVTPDRSQTSQ 1090
Query: 869 -----KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 920
+A+Y + Q EL + GD V ++ K D W+ G + G FP +YV+ L
Sbjct: 1091 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
Score = 31.6 bits (70), Expect = 4.3
Identities = 14/56 (25%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Query: 1045 PFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
P +A +++ + EL L++ D++ + ++ D W+ G G FP Y++ L
Sbjct: 819 PARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR--VGIFPRTYIELL 872
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 199 bits (505), Expect = 2e-50
Identities = 97/155 (62%), Positives = 119/155 (76%), Gaps = 2/155 (1%)
Query: 864 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 923
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 794 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 853
Query: 924 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 983
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 854 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 912
Query: 984 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYS 1017
+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 913 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPS 947
Score = 106 bits (265), Expect = 1e-22
Identities = 68/198 (34%), Positives = 105/198 (53%), Gaps = 31/198 (15%)
Query: 56 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 115
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ +
Sbjct: 358 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEE 412
Query: 116 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTY---RPLSKSHSDNSP------NAFKDASS 166
+ Y Y + S + +P T + P KS D+S + +D S
Sbjct: 413 NPYFPTYKFPELPEIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKS 472
Query: 167 PVPPPHVPP-----------------PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 209
P+ P P+P +SS+E++DW+PPD+KVDTRK+R+EP
Sbjct: 473 PLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEP 532
Query: 210 RSIFEYEPGKSSILQHER 227
+SI+EY+PGKSS+L +E+
Sbjct: 533 KSIYEYQPGKSSVLTNEK 550
Score = 102 bits (254), Expect = 2e-21
Identities = 44/55 (80%), Positives = 51/55 (92%)
Query: 1046 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
+QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 73.6 bits (179), Expect = 1e-12
Identities = 51/159 (32%), Positives = 76/159 (47%), Gaps = 29/159 (18%)
Query: 939 EIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 998
E+ A AK++F A T EL L+KGD V + K++DQNWYEG+ G R GIFP +Y+E++
Sbjct: 794 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELL- 850
Query: 999 KNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 1058
PP + K Q T + GE A +N+ +
Sbjct: 851 -----------PP--------------AEKAQPKKLTPVQVLEYGEAI-AKFNFNGDTQV 884
Query: 1059 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 1097
E+ R+ + I ++ + D+ W+ G T G FP YV
Sbjct: 885 EMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 923
Score = 65.9 bits (159), Expect = 2e-10
Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 2/92 (2%)
Query: 839 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 898
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 843 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 902
Query: 899 NWYEGEHHG--RVGIFPISYVEKLTPPEKAQP 928
NWYEG G R GIFPI+YV+ + P P
Sbjct: 903 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNP 934
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 15/119 (12%)
Query: 809 PRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA 868
P ++F + + H RGG R++ R S + ++RR TP++ +
Sbjct: 1180 PLGSAFPGSEAEQTERH---RGGEQAGRKAARRGGSQ-----QPQAQQRRVTPDRSQTSQ 1231
Query: 869 -----KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 920
+A+Y + Q EL + GD V ++ K D W+ G + G FP +YV+ L
Sbjct: 1232 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 38.1 bits (87), Expect = 0.046
Identities = 18/51 (35%), Positives = 29/51 (56%)
Query: 945 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 995
A Y++ + EL LR GD V ++++ D W+ G T + G FP +YV+
Sbjct: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 101 bits (252), Expect = 3e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 868 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 926
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 500
Query: 927 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 986
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 501 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 558
Query: 987 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 1045
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 559 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 604
Query: 1046 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 605 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 657
Score = 84.3 bits (207), Expect = 6e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 866 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 922
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661
Query: 923 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 982
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 662 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 715
Query: 983 TNRQGIFPVSYVEVVK 998
+ GIFP +Y++ ++
Sbjct: 716 --KSGIFPKNYIQFLQ 729
Score = 72.8 bits (177), Expect = 2e-12
Identities = 57/221 (25%), Positives = 99/221 (44%), Gaps = 36/221 (16%)
Query: 884 FKKGDTVYILRKIDQNWYE---GEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEI 940
+ +GD + +L++ + N+ E GE GRV + + + L +++P P +P +
Sbjct: 377 YMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDS 436
Query: 941 G--EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 998
G A+ ++F A+ +L+L G+ V LL+++D +WY G N+ GIFP +YV+V+
Sbjct: 437 GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVII 494
Query: 999 KNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 1058
+G + H R A + Y +D
Sbjct: 495 DIPEGGNGKRECVSSHCVKGSRC-------------------------VARFEYIGEQKD 529
Query: 1059 ELELRESDVIDVMEKCDDGWFVGTSR-RTKFFGTFPGNYVK 1098
EL E ++I + E ++ W G R RT G FP N+V+
Sbjct: 530 ELSFSEGEIIILKEYVNEEWARGEVRGRT---GIFPLNFVE 567
Score = 58.9 bits (141), Expect = 3e-08
Identities = 36/94 (38%), Positives = 50/94 (53%), Gaps = 11/94 (11%)
Query: 831 GALQDRESPRSYSSTLTDMGRSAPRERRG----TPEKEKLPAKAVYDFKAQTSKELSFKK 886
G LQDRE + + R P E + P+ K AKA+YDF+ + ELSFK
Sbjct: 642 GRLQDREG--IFPAVFV---RPCPAEAKSMLAIVPKGRK--AKALYDFRGENEDELSFKA 694
Query: 887 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 920
GD + L +D +W GE G+ GIFP +Y++ L
Sbjct: 695 GDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 101 bits (252), Expect = 3e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 868 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 926
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 536
Query: 927 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 986
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 537 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 594
Query: 987 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 1045
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 595 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 640
Query: 1046 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 641 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 693
Score = 84.3 bits (207), Expect = 6e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 866 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 922
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697
Query: 923 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 982
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 698 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 751
Query: 983 TNRQGIFPVSYVEVVK 998
+ GIFP +Y++ ++
Sbjct: 752 --KSGIFPKNYIQFLQ 765
Score = 72.8 bits (177), Expect = 2e-12
Identities = 57/221 (25%), Positives = 99/221 (44%), Gaps = 36/221 (16%)
Query: 884 FKKGDTVYILRKIDQNWYE---GEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEI 940
+ +GD + +L++ + N+ E GE GRV + + + L +++P P +P +
Sbjct: 413 YMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDS 472
Query: 941 G--EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 998
G A+ ++F A+ +L+L G+ V LL+++D +WY G N+ GIFP +YV+V+
Sbjct: 473 GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVII 530
Query: 999 KNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 1058
+G + H R A + Y +D
Sbjct: 531 DIPEGGNGKRECVSSHCVKGSRC-------------------------VARFEYIGEQKD 565
Query: 1059 ELELRESDVIDVMEKCDDGWFVGTSR-RTKFFGTFPGNYVK 1098
EL E ++I + E ++ W G R RT G FP N+V+
Sbjct: 566 ELSFSEGEIIILKEYVNEEWARGEVRGRT---GIFPLNFVE 603
Score = 58.9 bits (141), Expect = 3e-08
Identities = 36/94 (38%), Positives = 50/94 (53%), Gaps = 11/94 (11%)
Query: 831 GALQDRESPRSYSSTLTDMGRSAPRERRG----TPEKEKLPAKAVYDFKAQTSKELSFKK 886
G LQDRE + + R P E + P+ K AKA+YDF+ + ELSFK
Sbjct: 678 GRLQDREG--IFPAVFV---RPCPAEAKSMLAIVPKGRK--AKALYDFRGENEDELSFKA 730
Query: 887 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 920
GD + L +D +W GE G+ GIFP +Y++ L
Sbjct: 731 GDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 101 bits (252), Expect = 3e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 868 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 926
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 500 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 559
Query: 927 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 986
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 560 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 617
Query: 987 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 1045
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 618 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 663
Query: 1046 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 664 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 716
Score = 84.3 bits (207), Expect = 6e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 866 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 922
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
Query: 923 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 982
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 721 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 774
Query: 983 TNRQGIFPVSYVEVVK 998
+ GIFP +Y++ ++
Sbjct: 775 --KSGIFPKNYIQFLQ 788
Score = 81.6 bits (200), Expect = 4e-15
Identities = 68/256 (26%), Positives = 112/256 (43%), Gaps = 41/256 (16%)
Query: 854 PRERRGTPEKEKLPAKAVY-----DFKAQTSKELSFKKGDTVYILRKIDQNWYE---GEH 905
PR + G P K + D +Q ELS K+GD + +L++ + N+ E GE
Sbjct: 401 PRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGED 460
Query: 906 HGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIG--EAIAKYNFNADTNVELSLRKGD 963
GRV + + + L +++P P +P + G A+ ++F A+ +L+L G+
Sbjct: 461 TGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGE 520
Query: 964 RVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHS 1023
V LL+++D +WY G N+ GIFP +YV+V+ +G + H R
Sbjct: 521 IVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRC-- 576
Query: 1024 LSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTS 1083
A + Y +DEL E ++I + E ++ W G
Sbjct: 577 -----------------------VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV 613
Query: 1084 R-RTKFFGTFPGNYVK 1098
R RT G FP N+V+
Sbjct: 614 RGRT---GIFPLNFVE 626
Score = 59.3 bits (142), Expect = 2e-08
Identities = 50/250 (20%), Positives = 100/250 (40%), Gaps = 30/250 (12%)
Query: 850 GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRV 909
G++ P ++ T + P +++K+L F + + L+K N G +
Sbjct: 330 GKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKS 389
Query: 910 GIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLK 969
+F + + PP + +P P + IA + + ELS ++GD +++LK
Sbjct: 390 QVFKNQ--DPVLPP-RPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKRGDVLVMLK 446
Query: 970 RVDQNWYE-GKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 1028
+ + N+ E K T R + + + + ++ + ++
Sbjct: 447 QTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR------------------------SR 482
Query: 1029 PQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKF 1088
P P + + G L+++ D+L L +++ ++EK D W+ G R
Sbjct: 483 PNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ-- 540
Query: 1089 FGTFPGNYVK 1098
G FP NYVK
Sbjct: 541 IGIFPANYVK 550
Score = 58.9 bits (141), Expect = 3e-08
Identities = 36/94 (38%), Positives = 50/94 (53%), Gaps = 11/94 (11%)
Query: 831 GALQDRESPRSYSSTLTDMGRSAPRERRG----TPEKEKLPAKAVYDFKAQTSKELSFKK 886
G LQDRE + + R P E + P+ K AKA+YDF+ + ELSFK
Sbjct: 701 GRLQDREG--IFPAVFV---RPCPAEAKSMLAIVPKGRK--AKALYDFRGENEDELSFKA 753
Query: 887 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 920
GD + L +D +W GE G+ GIFP +Y++ L
Sbjct: 754 GDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 93.2 bits (230), Expect = 1e-18
Identities = 61/187 (32%), Positives = 98/187 (52%), Gaps = 25/187 (13%)
Query: 840 RSYSSTLTD---------MGRSAPRERRGTPEKEKLP----AKAVYDFKAQTSKELSFKK 886
RS SST+ + G PR + +P +P AKA+Y+++ + +L F K
Sbjct: 98 RSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSK 157
Query: 887 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK 946
GD + + R++D+NWY GE +G G FP ++V+ + P P PP Q + + K
Sbjct: 158 GDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKP-------LPQPPPQCKALYDFEVK 210
Query: 947 YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAED 1006
+ AD + L K D + +++RVD+NW EG + ++ GIFP+SYVE K +
Sbjct: 211 -DKEADKDC-LPFAKDDVLTVIRRVDENWAEGML--ADKIGIFPISYVE-FNSAAKQLIE 265
Query: 1007 YPDPPIP 1013
+ PP+P
Sbjct: 266 WDKPPVP 272
Score = 72.0 bits (175), Expect = 3e-12
Identities = 31/52 (59%), Positives = 37/52 (71%)
Query: 1046 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 1097
+ A+Y YTPR EDELELR+ ++ V E+C DGWF GTS T G FPGNYV
Sbjct: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
Score = 55.8 bits (133), Expect = 2e-07
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 1044 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
E + + +Y P++E ELEL+E D++ V +K +DGWF GT +R G FPG++V+ +
Sbjct: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
Score = 44.7 bits (104), Expect = 5e-04
Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 944 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 1003
+A Y + EL LRKG+ ++ +R W++G T++ G+FP +YV V T+
Sbjct: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV---TRA 507
Query: 1004 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 1043
+ +P S + ++ P + +QG G
Sbjct: 508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547
Score = 44.7 bits (104), Expect = 5e-04
Identities = 18/54 (33%), Positives = 34/54 (62%), Gaps = 2/54 (3%)
Query: 869 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 920
+ V + Q+ EL K+GD V++ +K + W++G + +G+ G+FP S+VE +
Sbjct: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
Score = 43.9 bits (102), Expect = 8e-04
Identities = 28/123 (22%), Positives = 50/123 (40%), Gaps = 30/123 (24%)
Query: 903 GEHHGRVGIFPI------------------SYVEKLTPPEKAQPARPPPPAQPGEIGEAI 944
G HGR G P+ ++ K + + A P PPP +G +
Sbjct: 764 GGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVL 823
Query: 945 AK------------YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 992
+ ++ + EL L++GD V + K+ + W++G + + G+FP S
Sbjct: 824 NESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGS 883
Query: 993 YVE 995
+VE
Sbjct: 884 FVE 886
Score = 39.3 bits (90), Expect = 0.021
Identities = 15/54 (27%), Positives = 29/54 (53%), Gaps = 2/54 (3%)
Query: 870 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLT 921
A+Y + + EL +KG+ + + W++G H ++G+FP +YV +T
Sbjct: 452 AIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
Score = 34.7 bits (78), Expect = 0.51
Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 1047 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
+ALYNY + +L+ + D+I + + D+ W+ G G FP N+V+
Sbjct: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHG--EVNGIHGFFPTNFVQ 189
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 90.9 bits (224), Expect = 6e-18
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%)
Query: 869 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 918
KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE
Sbjct: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321
Query: 919 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 973
+L +K PA P+ G + ++ V R+ D K+
Sbjct: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381
Query: 974 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 1028
+ ++R + + V + + + A D + H + +SS+
Sbjct: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439
Query: 1029 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 1076
P GE + ALY Y P+ DELEL + ++ V+EKC D
Sbjct: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499
Query: 1077 GWFVGTSRRTKFFGTFPGNYV 1097
GWF G S RT G FPGNYV
Sbjct: 500 GWFKGASLRTGVSGVFPGNYV 520
Score = 81.6 bits (200), Expect = 4e-15
Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 21/154 (13%)
Query: 869 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 928
KA+Y ++ + +L F KGD + + RK+D+ WY GE HG G P SY++ + P A P
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
Query: 929 ARPPPPAQPGEIGEAIAKYNFNADTNVE----LSLRKGDRVILLKRVDQNWYEGKIPGTN 984
+ A Y+F + L+ K + + +L+RVD+NW EG + +
Sbjct: 260 -------------QGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GD 304
Query: 985 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSS 1018
+ GIFP+ YVE+ + E D P P + SS
Sbjct: 305 KIGIFPLLYVELNDSAKQLIE--MDKPCPAAASS 336
Score = 54.7 bits (130), Expect = 5e-07
Identities = 22/55 (40%), Positives = 39/55 (70%)
Query: 1044 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+
Sbjct: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 53.5 bits (127), Expect = 1e-06
Identities = 42/179 (23%), Positives = 74/179 (41%), Gaps = 47/179 (26%)
Query: 924 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 983
E A P P + A Y++ +L KGD ++L ++VD+ WY G++ GT
Sbjct: 180 ELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGT 239
Query: 984 NRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 1043
QG P SY++ ++ P+PH+ PQ
Sbjct: 240 --QGFLPASYIQCIQ------------PLPHA------------PPQG------------ 261
Query: 1044 EPFQALYNYTPRNEDE----LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
+ALY++ +++D+ L + +++ V+ + D+ W G G FP YV+
Sbjct: 262 ---KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDK--IGIFPLLYVE 315
Score = 52.0 bits (123), Expect = 3e-06
Identities = 46/144 (31%), Positives = 66/144 (45%), Gaps = 17/144 (11%)
Query: 809 PRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLP 867
PR+A+ + D A+ SC A ++ S ST T + R+A +GTP K +LP
Sbjct: 414 PRAAA-RIGDLAHLSC-------AAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLP 465
Query: 868 AK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTP 922
A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP
Sbjct: 466 LNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TP 522
Query: 923 PEKAQPARPPPPAQPGEIGEAIAK 946
+ PP G +AK
Sbjct: 523 VSRVPAGGAGPPRNNVVGGSPLAK 546
Score = 49.3 bits (116), Expect = 2e-05
Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 6/84 (7%)
Query: 841 SYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSFKKGDTVYILRKI 896
S T R AP PE + LP + V + Q+ E+ K+GD V++ +K
Sbjct: 797 SLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR 856
Query: 897 DQNWYEG--EHHGRVGIFPISYVE 918
+ WY+G + +GR G+FP S+VE
Sbjct: 857 EDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 48.5 bits (114), Expect = 3e-05
Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 902 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 951
E E G +G+ P+ S T P + P RP P P E + Y +
Sbjct: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838
Query: 952 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 995
+ +EL ++GD V + K+ + WY+G + R G+FP S+VE
Sbjct: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 39.7 bits (91), Expect = 0.016
Identities = 21/76 (27%), Positives = 34/76 (44%)
Query: 933 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 992
PP + +A Y + + EL L KG+ +L++ W++G T G+FP +
Sbjct: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518
Query: 993 YVEVVKKNTKGAEDYP 1008
YV V + G P
Sbjct: 519 YVTPVSRVPAGGAGPP 534
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 87.8 bits (216), Expect = 5e-17
Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 33/243 (13%)
Query: 874 FKAQTSKELSFKKGDTVYILRKID-QNWYEGEHHGRVGIFPISYVEKLTPP--------- 923
++AQ ELS GD V +R + + W GE GR G+FP V+++
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 924 -----EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEG 978
+ PA+ P P + ++ ++++ + EL L+ G+ V ++K ++ W+ G
Sbjct: 69 PRCARRRGHPAKHPRPQRWCKVN-----FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG 123
Query: 979 KIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI--PHSYSSDRIHSLSSNKPQRPVFTH 1036
K G + G FP ++VE++ + PD P P ++ SL+ + P + T
Sbjct: 124 KKNG--QLGAFPSNFVELLDSGPPSLGN-PDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
Query: 1037 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPG 1094
+ E ++ L++Y P DEL LR DV+ V+ K D GW+ G + + G FP
Sbjct: 181 SH----PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPD 234
Query: 1095 NYV 1097
N+V
Sbjct: 235 NFV 237
Score = 72.0 bits (175), Expect = 3e-12
Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 30/166 (18%)
Query: 857 RRGTPEKEKLP---AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 913
RRG P K P K + + + + EL + G+ V ++++I+ W+ G+ +G++G FP
Sbjct: 74 RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
Query: 914 ISYVEKLT--PPEKAQPARP---PPPAQPGEIGEAI------------------AKYNFN 950
++VE L PP P P P P +P ++ +++
Sbjct: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
Query: 951 ADTNVELSLRKGDRVILLKRV--DQNWYEGKIPGTNRQGIFPVSYV 994
+ EL+LR+GD V +L + D+ W+EG+ G R+G+FP ++V
Sbjct: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFV 237
Score = 59.7 bits (143), Expect = 1e-08
Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 22/160 (13%)
Query: 942 EAIAKYNFNADTNVELSLRKGDRVILLKRVD-QNWYEGKIPGTNRQGIFPVSYVEVVKKN 1000
E + + A ELSL GD V ++ V + W G+ G R G+FP V+ + +
Sbjct: 2 EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
Query: 1001 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDEL 1060
+G+ + P R H +PQR + ++Y+P DEL
Sbjct: 60 LRGSGEARRPRCARR----RGHPAKHPRPQRWCKVN-------------FSYSPEQADEL 102
Query: 1061 ELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
+L+ ++++++++ +DGW++G ++ G FP N+V+ L
Sbjct: 103 KLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
Score = 48.9 bits (115), Expect = 3e-05
Identities = 22/64 (34%), Positives = 39/64 (60%), Gaps = 2/64 (3%)
Query: 869 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 926
+ ++D++ + EL+ ++GD V +L K D+ W+EGE GR G+FP ++V P +K
Sbjct: 187 RVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKL 246
Query: 927 QPAR 930
P +
Sbjct: 247 VPRK 250
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 86.7 bits (213), Expect = 1e-16
Identities = 78/268 (29%), Positives = 127/268 (47%), Gaps = 51/268 (19%)
Query: 852 SAPRERRGTPEK-EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVG 910
S+P G EK E L A+A+Y ++A+ L+F K D + +L + D W+ GE G+ G
Sbjct: 901 SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKG 959
Query: 911 IFPISYVEKLTPP----------EKAQPAR----PPPPAQPGEIGEA-IAKYNFNADTNV 955
FP SYV+ ++ P PA P A+P GE IA Y + +
Sbjct: 960 WFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQG 1019
Query: 956 ELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHS 1015
+L+ ++GD VIL+ + D +W+ G + ++ G+FP +YV + K+++G S
Sbjct: 1020 DLTFQQGD-VILVTKKDGDWWTGTVG--DKAGVFPSNYVRL--KDSEG-----------S 1063
Query: 1016 YSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCD 1075
++ + SL KP E Q + +YT ++L L +I + +K
Sbjct: 1064 GTAGKTGSLGK-KP--------------EIAQVIASYTATGPEQLTLAPGQLILIRKKNP 1108
Query: 1076 DGWFVGTSR---RTKFFGTFPGNYVKRL 1100
GW+ G + + + G FP NYVK L
Sbjct: 1109 GGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 84.7 bits (208), Expect = 4e-16
Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 33/232 (14%)
Query: 870 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 929
A+Y +++ +L+F++GD + + +K D +W+ G + G+FP +YV
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 930 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP--GTNRQ- 986
+ + EI + IA Y A +L+L G +++ K+ W+EG++ G RQ
Sbjct: 1068 KTGSLGKKPEIAQVIASYT--ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 987 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF 1046
G FP +YV+++ T ++ +P + Q G
Sbjct: 1126 GWFPANYVKLLSPGTS--------------------KITPTEPPKSTALAAVCQVIG--- 1162
Query: 1047 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
+Y+YT +N+DEL + +I+V+ K D W+ G G FP NYVK
Sbjct: 1163 --MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ--VGLFPSNYVK 1210
Score = 75.5 bits (184), Expect = 3e-13
Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)
Query: 846 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 905
L D S + G+ K+ A+ + + A ++L+ G + I +K W+EGE
Sbjct: 1057 LKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGEL 1116
Query: 906 HGR-----VGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSL 959
R +G FP +YV+ L+P K P PP + + I Y++ A + EL+
Sbjct: 1117 QARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAF 1176
Query: 960 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 996
KG + +L + D +W++G++ G + G+FP +YV++
Sbjct: 1177 NKGQIINVLNKEDPDWWKGEVNG--QVGLFPSNYVKL 1211
Score = 62.0 bits (149), Expect = 3e-09
Identities = 54/179 (30%), Positives = 80/179 (44%), Gaps = 20/179 (11%)
Query: 923 PEKAQPARPPPPAQPGEIGEAI---AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGK 979
P A + P P GE E + A Y + A + L+ K D + +L++ D W+ G+
Sbjct: 895 PATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GE 953
Query: 980 IPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENI 1039
+ G ++G FP SYV+++ PI S S D S S +R
Sbjct: 954 VQG--QKGWFPKSYVKLISG-----------PIRKSTSMDSGSSESPASLKRVASPAAKP 1000
Query: 1040 QGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
GE F A+Y Y + +L ++ DVI V +K D W+ GT G FP NYV+
Sbjct: 1001 VVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKA--GVFPSNYVR 1056
Score = 57.8 bits (138), Expect = 6e-08
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 871 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 927
+YD+ AQ EL+F KG + +L K D +W++GE +G+VG+FP +YV+ T + +Q
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 55.5 bits (132), Expect = 3e-07
Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 34/243 (13%)
Query: 869 KAVYDFKAQTSKELSFKKGDTVYILRK-IDQN------WYEGEHHGRVGIFPISYVEKLT 921
+A+Y F++++ E++ + GD V + + +D++ W GE G+ G FP +Y EK+
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 922 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 981
E P +P + + + +T L++ + NW
Sbjct: 806 ENEVPAPVKPVTDSTSAPAPKLALR-----ETPAPLAVTSSEP----STTPNNW------ 850
Query: 982 GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHEN-IQ 1040
+ +P S E K T + + P S+ ++ S+ P + + +
Sbjct: 851 -ADFSSTWPTSTNE--KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVL 907
Query: 1041 GGGEPF-----QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 1095
G GE QALY + + ++ L ++DVI V+E+ D WF G + K G FP +
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQK--GWFPKS 964
Query: 1096 YVK 1098
YVK
Sbjct: 965 YVK 967
Score = 32.0 bits (71), Expect = 3.3
Identities = 16/62 (25%), Positives = 31/62 (50%), Gaps = 9/62 (14%)
Query: 1046 FQALYNYTPRNEDELELRESDV-------IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
++ALY + R+ DE+ ++ D+ +D + + GW G + G FP NY +
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT--GWFPANYAE 802
Query: 1099 RL 1100
++
Sbjct: 803 KI 804
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 86.7 bits (213), Expect = 1e-16
Identities = 78/268 (29%), Positives = 127/268 (47%), Gaps = 51/268 (19%)
Query: 852 SAPRERRGTPEK-EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVG 910
S+P G EK E L A+A+Y ++A+ L+F K D + +L + D W+ GE G+ G
Sbjct: 901 SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKG 959
Query: 911 IFPISYVEKLTPP----------EKAQPAR----PPPPAQPGEIGEA-IAKYNFNADTNV 955
FP SYV+ ++ P PA P A+P GE IA Y + +
Sbjct: 960 WFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQG 1019
Query: 956 ELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHS 1015
+L+ ++GD VIL+ + D +W+ G + ++ G+FP +YV + K+++G S
Sbjct: 1020 DLTFQQGD-VILVTKKDGDWWTGTVG--DKAGVFPSNYVRL--KDSEG-----------S 1063
Query: 1016 YSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCD 1075
++ + SL KP E Q + +YT ++L L +I + +K
Sbjct: 1064 GTAGKTGSLGK-KP--------------EIAQVIASYTATGPEQLTLAPGQLILIRKKNP 1108
Query: 1076 DGWFVGTSR---RTKFFGTFPGNYVKRL 1100
GW+ G + + + G FP NYVK L
Sbjct: 1109 GGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 84.7 bits (208), Expect = 4e-16
Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 33/232 (14%)
Query: 870 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 929
A+Y +++ +L+F++GD + + +K D +W+ G + G+FP +YV
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 930 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP--GTNRQ- 986
+ + EI + IA Y A +L+L G +++ K+ W+EG++ G RQ
Sbjct: 1068 KTGSLGKKPEIAQVIASYT--ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 987 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF 1046
G FP +YV+++ T ++ +P + Q G
Sbjct: 1126 GWFPANYVKLLSPGTS--------------------KITPTEPPKSTALAAVCQVIG--- 1162
Query: 1047 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
+Y+YT +N+DEL + +I+V+ K D W+ G G FP NYVK
Sbjct: 1163 --MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ--VGLFPSNYVK 1210
Score = 75.5 bits (184), Expect = 3e-13
Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)
Query: 846 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 905
L D S + G+ K+ A+ + + A ++L+ G + I +K W+EGE
Sbjct: 1057 LKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGEL 1116
Query: 906 HGR-----VGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSL 959
R +G FP +YV+ L+P K P PP + + I Y++ A + EL+
Sbjct: 1117 QARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAF 1176
Query: 960 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 996
KG + +L + D +W++G++ G + G+FP +YV++
Sbjct: 1177 NKGQIINVLNKEDPDWWKGEVNG--QVGLFPSNYVKL 1211
Score = 62.0 bits (149), Expect = 3e-09
Identities = 54/179 (30%), Positives = 80/179 (44%), Gaps = 20/179 (11%)
Query: 923 PEKAQPARPPPPAQPGEIGEAI---AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGK 979
P A + P P GE E + A Y + A + L+ K D + +L++ D W+ G+
Sbjct: 895 PATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GE 953
Query: 980 IPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENI 1039
+ G ++G FP SYV+++ PI S S D S S +R
Sbjct: 954 VQG--QKGWFPKSYVKLISG-----------PIRKSTSMDSGSSESPASLKRVASPAAKP 1000
Query: 1040 QGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
GE F A+Y Y + +L ++ DVI V +K D W+ GT G FP NYV+
Sbjct: 1001 VVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKA--GVFPSNYVR 1056
Score = 57.8 bits (138), Expect = 6e-08
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 871 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 927
+YD+ AQ EL+F KG + +L K D +W++GE +G+VG+FP +YV+ T + +Q
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 55.5 bits (132), Expect = 3e-07
Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 34/243 (13%)
Query: 869 KAVYDFKAQTSKELSFKKGDTVYILRK-IDQN------WYEGEHHGRVGIFPISYVEKLT 921
+A+Y F++++ E++ + GD V + + +D++ W GE G+ G FP +Y EK+
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 922 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 981
E P +P + + + +T L++ + NW
Sbjct: 806 ENEVPAPVKPVTDSTSAPAPKLALR-----ETPAPLAVTSSEP----STTPNNW------ 850
Query: 982 GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHEN-IQ 1040
+ +P S E K T + + P S+ ++ S+ P + + +
Sbjct: 851 -ADFSSTWPTSTNE--KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVL 907
Query: 1041 GGGEPF-----QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 1095
G GE QALY + + ++ L ++DVI V+E+ D WF G + K G FP +
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQK--GWFPKS 964
Query: 1096 YVK 1098
YVK
Sbjct: 965 YVK 967
Score = 32.0 bits (71), Expect = 3.3
Identities = 16/62 (25%), Positives = 31/62 (50%), Gaps = 9/62 (14%)
Query: 1046 FQALYNYTPRNEDELELRESDV-------IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
++ALY + R+ DE+ ++ D+ +D + + GW G + G FP NY +
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT--GWFPANYAE 802
Query: 1099 RL 1100
++
Sbjct: 803 KI 804
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 83.2 bits (204), Expect = 1e-15
Identities = 53/165 (32%), Positives = 96/165 (58%), Gaps = 12/165 (7%)
Query: 944 IAKYNFNADTNVELSLRKGDRVILLKRV-DQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 1002
I +Y+++A + EL++R G+ + +K++ ++ W EG++ G R+G+FP ++V+ +K+ T+
Sbjct: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRETE 62
Query: 1003 GAED-YPDPPIPHSYSSDRIHSLSS-NKPQRPVFTH---ENIQGGGEPFQA--LYNYTPR 1055
+D P H + + +S+ P + H +NI+ + Q L+ Y P+
Sbjct: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQ 122
Query: 1056 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
NEDELEL+ D+ID+ E+ ++GW+ GT G FP N+VK L
Sbjct: 123 NEDELELKVGDIIDINEEVEEGWWSGTLNNK--LGLFPSNFVKEL 165
Score = 55.8 bits (133), Expect = 2e-07
Identities = 65/325 (20%), Positives = 128/325 (39%), Gaps = 100/325 (30%)
Query: 872 YDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHHGRVGIFPISYVEKL-TPPEKAQPA 929
YD+ A EL+ + G+ + ++K+ ++ W EGE +GR G+FP ++V+++ E +
Sbjct: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
Query: 930 RPPPPAQPGEIGEAIAK--------------------------------YNFNADTNVEL 957
P + G + + + + + EL
Sbjct: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
Query: 958 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG----AED------- 1006
L+ GD + + + V++ W+ G + N+ G+FP ++V+ ++ G A+D
Sbjct: 128 ELKVGDIIDINEEVEEGWWSGTL--NNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLA 185
Query: 1007 YPDPPIP---------------------------HSYSSDRIHSLSSN------KPQRPV 1033
P PIP S ++ + +S+ KP++P+
Sbjct: 186 GPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPL 245
Query: 1034 -------------FTHENIQG---GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CD 1075
T + +G E + L+ Y NEDEL +E ++I ++ K +
Sbjct: 246 ILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
Query: 1076 DGWFVGTSRRTKFFGTFPGNYVKRL 1100
GW+ G + G FP N+ ++
Sbjct: 306 AGWWRGELNGKE--GVFPDNFAVQI 328
Score = 50.8 bits (120), Expect = 7e-06
Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 5/88 (5%)
Query: 863 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKL 920
K K + ++ ++ EL+FK+G+ ++++ K + W+ GE +G+ G+FP ++ ++
Sbjct: 269 KAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328
Query: 921 TPPEK--AQPARPPPPAQ-PGEIGEAIA 945
+K +P +PPPPA+ P E IA
Sbjct: 329 NELDKDFPKPKKPPPPAKAPAPKPELIA 356
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 82.8 bits (203), Expect = 2e-15
Identities = 50/162 (30%), Positives = 90/162 (55%), Gaps = 12/162 (7%)
Query: 942 EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNT 1001
EAI ++++ A + EL++ G+ + +++ D W+EG+I G R+G+FP ++V +KK
Sbjct: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
Query: 1002 KG---AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 1058
K P+ P+ S + + LSS R T++ + Q ++Y P+N+D
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSL--LSSETILR---TNKRGERRRRRCQVAFSYLPQNDD 115
Query: 1059 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
ELEL+ D+I+V+ + ++GW+ G G FP N++K L
Sbjct: 116 ELELKVGDIIEVVGEVEEGWWEGVLNGKT--GMFPSNFIKEL 155
Score = 66.2 bits (160), Expect = 2e-10
Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)
Query: 863 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 920
K K K ++ ++AQ EL+ K+GD V ++ K ID W+EGE +GR G+FP ++V KL
Sbjct: 267 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 325
Query: 921 TPP----EKAQPARPPPPAQP 937
PP E +P +PPPP+ P
Sbjct: 326 LPPDFEKEGNRPKKPPPPSAP 346
Score = 63.5 bits (153), Expect = 1e-09
Identities = 37/148 (25%), Positives = 73/148 (49%), Gaps = 26/148 (17%)
Query: 872 YDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARP 931
+D++AQ EL+ G+ + +RK D W+EG+ +GR G+FP ++V ++ K P
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN 67
Query: 932 PPPAQP-------------------GEIGEAIAK-----YNFNADTNVELSLRKGDRVIL 967
P +P + GE + +++ + EL L+ GD + +
Sbjct: 68 KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127
Query: 968 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 995
+ V++ W+EG + G + G+FP ++++
Sbjct: 128 VGEVEEGWWEGVLNG--KTGMFPSNFIK 153
Score = 61.6 bits (148), Expect = 4e-09
Identities = 46/241 (19%), Positives = 104/241 (43%), Gaps = 13/241 (5%)
Query: 862 EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLT 921
E+ + + + + Q EL K GD + ++ ++++ W+EG +G+ G+FP +++++L+
Sbjct: 97 ERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELS 156
Query: 922 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 981
+ E + D++ S +G + Q K+
Sbjct: 157 GESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVK 211
Query: 982 GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQG 1041
G IF +++ ++ + D+ +P + + ++ P ++
Sbjct: 212 GVGFGDIFKDKPIKLRPRSIEVENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTK 267
Query: 1042 GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKR 1099
+ + ++ Y +N+DEL ++E D++ ++ K D GW+ G + G FP N+VK
Sbjct: 268 SKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKL 325
Query: 1100 L 1100
L
Sbjct: 326 L 326
Score = 47.8 bits (112), Expect = 6e-05
Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)
Query: 947 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 1004
+ + A + EL++++GD V L+ + +D W+EG++ G R+G+FP ++V+++ + +
Sbjct: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 333
Query: 1005 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 1056
+ P P P S +++R H + P+RP P + P
Sbjct: 334 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 384
Query: 1057 EDELELRESDV 1067
E +L+L++ V
Sbjct: 385 EPKLDLQKPSV 395
Score = 32.3 bits (72), Expect = 2.5
Identities = 36/133 (27%), Positives = 59/133 (44%), Gaps = 17/133 (12%)
Query: 158 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWD--PPDRKVDTRKFRSEPRSIFEY 215
P+ K+ + P PP PP P ++ ++ KH+ PP+R + R+E + E
Sbjct: 328 PDFEKEGNRPKKPP--PPSAPVIKQGAGTTERKHEIKKIPPERP-EMLPNRTEEKERPER 384
Query: 216 EPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS 275
EP K + + PA I RP + S++ R + P P R +G + +
Sbjct: 385 EP-KLDLQKPSVPA------IPPKKPRPPKTNSLS-----RPGALPPRRPERPVGPLTHT 432
Query: 276 RTSPGRVDLPGSS 288
R ++DL GSS
Sbjct: 433 RGDSPKIDLAGSS 445
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 82.4 bits (202), Expect = 2e-15
Identities = 60/185 (32%), Positives = 97/185 (52%), Gaps = 38/185 (20%)
Query: 829 RGGALQDRESPRSYSSTLTD--MGRSAPRERRGTPEK---------EKLP-AKAVYDFKA 876
RGG+ + R + TL D R+ PR + +P + + +P AKA+ +++
Sbjct: 84 RGGSFR-----RPGTMTLQDGRKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRG 138
Query: 877 QTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQ 936
Q +L F KGD + + R++D+NWY+GE +G G FP S VE + Q +PPP +
Sbjct: 139 QNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI-----KQLPQPPPLCR 193
Query: 937 PGEIGEAIAKYNFN------ADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFP 990
A YNF+ ++ L+ K D + ++ RVD+NW EGK+ ++ GIFP
Sbjct: 194 --------ALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GDKVGIFP 243
Query: 991 VSYVE 995
+ +VE
Sbjct: 244 ILFVE 248
Score = 53.1 bits (126), Expect = 1e-06
Identities = 41/148 (27%), Positives = 64/148 (43%), Gaps = 47/148 (31%)
Query: 940 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 999
+ A A N+ +L KGD ++L +++D+NWY+G+I G + G FP S VEV+K+
Sbjct: 127 VPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVEVIKQ 184
Query: 1000 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPR---- 1055
P PP P+ +ALYN+ R
Sbjct: 185 -------LPQPP--------------------PLC------------RALYNFDLRGKDK 205
Query: 1056 --NEDELELRESDVIDVMEKCDDGWFVG 1081
N+D L + D+I V+ + D+ W G
Sbjct: 206 SENQDCLTFLKDDIITVISRVDENWAEG 233
Score = 51.2 bits (121), Expect = 5e-06
Identities = 23/52 (44%), Positives = 32/52 (61%)
Query: 1046 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 1097
F AL++Y+ DEL+L++ + + V+ KC DGW G S T G FP NYV
Sbjct: 385 FVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
Score = 41.2 bits (95), Expect = 0.005
Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 3/75 (4%)
Query: 944 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 1003
+A ++++A EL L+KG+ V +L + W G T R GIFP +YV + + T
Sbjct: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKT-- 443
Query: 1004 AEDYPDPPIPHSYSS 1018
+PD P Y++
Sbjct: 444 -SSFPDSRSPGLYTT 457
Score = 38.1 bits (87), Expect = 0.046
Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 2/50 (4%)
Query: 870 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH--HGRVGIFPISYV 917
A++ + A EL +KG+ V +L K W G GRVGIFP +YV
Sbjct: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
Score = 30.8 bits (68), Expect = 7.4
Identities = 15/52 (28%), Positives = 26/52 (50%), Gaps = 2/52 (3%)
Query: 1047 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
+AL NY +N +L + D+I + + D+ W+ G G FP + V+
Sbjct: 131 KALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVE 180
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 81.3 bits (199), Expect = 5e-15
Identities = 78/291 (26%), Positives = 121/291 (41%), Gaps = 63/291 (21%)
Query: 864 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 923
E L A+A+ + A+ L+F K D + +L + +NW+ GE HG G FP SYV K+ P
Sbjct: 872 ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYV-KIIPG 929
Query: 924 EKAQPARPP---------PPAQPGEIGEA-IAKYNFNADTNVELSLRKGDRVILLKRVDQ 973
+ + P P + +GE IA Y +++ +L+ +G+ +++ ++ D
Sbjct: 930 SEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DG 988
Query: 974 NWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDYPDPPIPH---SYSSDRIHSLS 1025
W+ G I +R GIFP +YV E +K P I +Y + LS
Sbjct: 989 EWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLS 1046
Query: 1026 SNKPQRPVFTHEN--------IQGGGEPFQ------------------------------ 1047
Q + +N +Q G+ Q
Sbjct: 1047 LAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVI 1106
Query: 1048 ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
A+Y+Y NEDEL + +I+VM K D W+ G G FP NYVK
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVK 1155
Score = 73.2 bits (178), Expect = 1e-12
Identities = 59/218 (27%), Positives = 99/218 (45%), Gaps = 26/218 (11%)
Query: 831 GALQDRES--PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGD 888
G++ DR P +Y D + G K+ A+ + A S++LS G
Sbjct: 993 GSIGDRSGIFPSNYVKP-KDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQ 1051
Query: 889 TVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEIGE 942
+ IL+K W++GE R G FP S+V+ L P E+A PA P + +
Sbjct: 1052 LILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------VCQ 1104
Query: 943 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 1002
IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS-- 1160
Query: 1003 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 1040
DP + ++ + +R + HE IQ
Sbjct: 1161 ------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1192
Score = 57.8 bits (138), Expect = 6e-08
Identities = 34/102 (33%), Positives = 50/102 (49%), Gaps = 7/102 (6%)
Query: 827 QDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PAKAVYDFKAQTSKELSFK 885
Q RG Q P S+ L P R TP + A+YD+ A ELSF
Sbjct: 1069 QARGKKRQKGWFPASHVKLL------GPSSERATPAFHPVCQVIAMYDYAANNEDELSFS 1122
Query: 886 KGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 927
KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1123 KGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1164
Score = 46.6 bits (109), Expect = 1e-04
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 869 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 926
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
Query: 927 QPARPPPPAQP 937
+ P P
Sbjct: 796 KAVSPKKALLP 806
Score = 43.9 bits (102), Expect = 8e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 1046 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 1100
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 735 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 789
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 81.3 bits (199), Expect = 5e-15
Identities = 78/291 (26%), Positives = 121/291 (41%), Gaps = 63/291 (21%)
Query: 864 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 923
E L A+A+ + A+ L+F K D + +L + +NW+ GE HG G FP SYV K+ P
Sbjct: 899 ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYV-KIIPG 956
Query: 924 EKAQPARPP---------PPAQPGEIGEA-IAKYNFNADTNVELSLRKGDRVILLKRVDQ 973
+ + P P + +GE IA Y +++ +L+ +G+ +++ ++ D
Sbjct: 957 SEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DG 1015
Query: 974 NWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDYPDPPIPH---SYSSDRIHSLS 1025
W+ G I +R GIFP +YV E +K P I +Y + LS
Sbjct: 1016 EWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLS 1073
Query: 1026 SNKPQRPVFTHEN--------IQGGGEPFQ------------------------------ 1047
Q + +N +Q G+ Q
Sbjct: 1074 LAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVI 1133
Query: 1048 ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
A+Y+Y NEDEL + +I+VM K D W+ G G FP NYVK
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVK 1182
Score = 73.2 bits (178), Expect = 1e-12
Identities = 59/218 (27%), Positives = 99/218 (45%), Gaps = 26/218 (11%)
Query: 831 GALQDRES--PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGD 888
G++ DR P +Y D + G K+ A+ + A S++LS G
Sbjct: 1020 GSIGDRSGIFPSNYVKP-KDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQ 1078
Query: 889 TVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEIGE 942
+ IL+K W++GE R G FP S+V+ L P E+A PA P + +
Sbjct: 1079 LILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------VCQ 1131
Query: 943 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 1002
IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS-- 1187
Query: 1003 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 1040
DP + ++ + +R + HE IQ
Sbjct: 1188 ------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1219
Score = 57.8 bits (138), Expect = 6e-08
Identities = 34/102 (33%), Positives = 50/102 (49%), Gaps = 7/102 (6%)
Query: 827 QDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PAKAVYDFKAQTSKELSFK 885
Q RG Q P S+ L P R TP + A+YD+ A ELSF
Sbjct: 1096 QARGKKRQKGWFPASHVKLL------GPSSERATPAFHPVCQVIAMYDYAANNEDELSFS 1149
Query: 886 KGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 927
KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1150 KGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Score = 46.6 bits (109), Expect = 1e-04
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 869 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 926
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 927 QPARPPPPAQP 937
+ P P
Sbjct: 823 KAVSPKKALLP 833
Score = 43.9 bits (102), Expect = 8e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 1046 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 1100
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 816
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,625,309
Number of Sequences: 37866
Number of extensions: 2811440
Number of successful extensions: 19560
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 328
Number of HSP's successfully gapped in prelim test: 385
Number of HSP's that attempted gapping in prelim test: 14828
Number of HSP's gapped (non-prelim): 3669
length of query: 1100
length of database: 18,247,518
effective HSP length: 113
effective length of query: 987
effective length of database: 13,968,660
effective search space: 13787067420
effective search space used: 13787067420
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.