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Search of human proteins with 14249672
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14249672 protein phosphatase 1, regulatory (inhibitor)
subunit 16A [Homo sapiens]
(528 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14249672 protein phosphatase 1, regulatory (inhibitor) subuni... 1068 0.0
gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 1... 474 e-134
gi|14195601 protein phosphatase 1, regulatory (inhibitor) subuni... 206 4e-53
gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit... 206 4e-53
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ... 202 5e-52
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun... 197 2e-50
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit... 197 2e-50
gi|62177127 myosin heavy chain Myr 8 [Homo sapiens] 155 9e-38
gi|219842214 protein phosphatase 1, regulatory (inhibitor) subun... 150 3e-36
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 116 6e-26
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 114 3e-25
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 103 3e-22
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 100 3e-21
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 100 3e-21
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 100 3e-21
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 100 3e-21
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 100 3e-21
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 99 1e-20
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 99 1e-20
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 99 1e-20
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 99 1e-20
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 97 5e-20
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 92 9e-19
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 92 1e-18
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 91 2e-18
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 91 3e-18
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 89 1e-17
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 88 2e-17
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 88 2e-17
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 88 2e-17
>gi|14249672 protein phosphatase 1, regulatory (inhibitor) subunit
16A [Homo sapiens]
Length = 528
Score = 1068 bits (2761), Expect = 0.0
Identities = 528/528 (100%), Positives = 528/528 (100%)
Query: 1 MAEHLELLAEMPMVGRMSTQERLKHAQKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAAS 60
MAEHLELLAEMPMVGRMSTQERLKHAQKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAAS
Sbjct: 1 MAEHLELLAEMPMVGRMSTQERLKHAQKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAAS 60
Query: 61 QGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMV 120
QGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMV
Sbjct: 61 QGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMV 120
Query: 121 QQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDE 180
QQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDE
Sbjct: 121 QQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDE 180
Query: 181 QTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAA 240
QTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAA
Sbjct: 181 QTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAA 240
Query: 241 ANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDET 300
ANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDET
Sbjct: 241 ANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDET 300
Query: 301 PLDVCGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDL 360
PLDVCGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDL
Sbjct: 301 PLDVCGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDL 360
Query: 361 YRKQHAQEAIVWQQPPPTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPV 420
YRKQHAQEAIVWQQPPPTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPV
Sbjct: 361 YRKQHAQEAIVWQQPPPTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPV 420
Query: 421 RHLYSKRLDRSVSYQLSPLDSTTPHTLVHDKAHHTLADLKRQRAAAKLQRPPPEGPESPE 480
RHLYSKRLDRSVSYQLSPLDSTTPHTLVHDKAHHTLADLKRQRAAAKLQRPPPEGPESPE
Sbjct: 421 RHLYSKRLDRSVSYQLSPLDSTTPHTLVHDKAHHTLADLKRQRAAAKLQRPPPEGPESPE 480
Query: 481 TAEPGLPGDTVTPQPDCGFRAGGDPPLLKLTAPAVEAPVERRPCCLLM 528
TAEPGLPGDTVTPQPDCGFRAGGDPPLLKLTAPAVEAPVERRPCCLLM
Sbjct: 481 TAEPGLPGDTVTPQPDCGFRAGGDPPLLKLTAPAVEAPVERRPCCLLM 528
>gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 16B
[Homo sapiens]
Length = 567
Score = 474 bits (1220), Expect = e-134
Identities = 270/567 (47%), Positives = 351/567 (61%), Gaps = 45/567 (7%)
Query: 1 MAEHLELLAEMPMVGRMSTQERLKHAQKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAAS 60
MA H++LL E+ ++ ++ T ERL+ AQKRRAQQ+K WAQ E++ Q +K ER R ++
Sbjct: 1 MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKR---ST 57
Query: 61 QGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMV 120
G K+V F SV LLEA+ RND EEVR FL + VSPDL NEDGLTALHQCCID+F E+V
Sbjct: 58 GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
Query: 121 QQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDE 180
+ LL GAN+NA D+E WTPLHAAATCGH++LV++L+ GA+LLAVN+DGNMPYDLC+DE
Sbjct: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
Query: 181 QTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAA 240
TLD +ET MA +GITQ+ I R PE +M+ DI + AG DL GATLLH+A
Sbjct: 178 PTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAG 237
Query: 241 ANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDET 300
ANG+ AA LLL+H + KD DGWEPLHAAA+WGQ+ + ELLV+HGA L+A++ MDE
Sbjct: 238 ANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEM 297
Query: 301 PLDVCGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDL 360
P+D+C +EE + LLELKHKHD ++++Q R +S L RRTSSAGSRGKVVRR SL+ RT+L
Sbjct: 298 PIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNL 357
Query: 361 YRKQHAQEAIVWQQPPPTSPEPPEDNDD---RQTGAELRPPPPEEDNPEVVRPHNGRVG- 416
YRK++ EAI+WQ+ N D +T E + P P + P ++ ++
Sbjct: 358 YRKEYEGEAILWQRSAAEDQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFPTKIPR 417
Query: 417 ---GSPVRH-------LYSKRL------------DRSVSY-QLSPLDSTTPHTLVHDKAH 453
PV + Y L D S++Y D+T P + +++
Sbjct: 418 GELDMPVENGLRAPVSAYQYALANGDVWKVHEVPDYSMAYGNPGVADATPPWSSYKEQSP 477
Query: 454 HTLADLKRQRAAAKLQRPP----------PEGPESPETAEPGLPGDTVTPQPDCGFR--- 500
TL +LKRQRAAAKL P ES + L G +P G
Sbjct: 478 QTLLELKRQRAAAKLLSHPFLSTHLGSSMARTGESSSEGKAPLIGGRTSPYSSNGTSVYY 537
Query: 501 --AGGDPPLLKLTAPAVEAPVERRPCC 525
GDPPLLK AP E + CC
Sbjct: 538 TVTSGDPPLLKFKAPIEEMEEKVHGCC 564
>gi|14195601 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform b [Homo sapiens]
Length = 998
Score = 206 bits (524), Expect = 4e-53
Identities = 132/404 (32%), Positives = 207/404 (51%), Gaps = 18/404 (4%)
Query: 21 ERLKHAQKRRAQQVKMW--AQAEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEA 78
+R + A+ RRA+Q++ W + E+E ++G G +P S +V F V L A
Sbjct: 10 KRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSP----RVRFEDGAVFLAA 65
Query: 79 AARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECW 138
+ D +EVR+ L G + N DGLTALHQ CID+ +MV+ L+E AN+N D+E W
Sbjct: 66 CSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGW 125
Query: 139 TPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQD 198
TPLHAAA+CG+L++ E I GA++ VN++G +P DL ++ D L + +GI
Sbjct: 126 TPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGI--- 182
Query: 199 SIEAARAVPELRMLDDIRSRLQAG--ADLHAPLDHGATLLHVAAANGFSEAAALLLEHRA 256
+E +R E +ML D R L +G D+ GAT LHVAAA G+SE LL++
Sbjct: 183 DLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARS-GATALHVAAAKGYSEVLRLLIQAGY 241
Query: 257 SLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLE 316
L+ +D DGW PLHAAA+WG +L D++ ++ + +TP DV +E + LE
Sbjct: 242 ELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA--DEGLVEHLE 299
Query: 317 LKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQQPP 376
L K +LR++ R+ L + K+ + LY ++ + + ++
Sbjct: 300 LLQKKQNVLRSEKETRNKL----IESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENK 355
Query: 377 PTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPV 420
+S E+ + +E + PE H+ S +
Sbjct: 356 ESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSI 399
>gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform a [Homo sapiens]
Length = 982
Score = 206 bits (524), Expect = 4e-53
Identities = 132/404 (32%), Positives = 207/404 (51%), Gaps = 18/404 (4%)
Query: 21 ERLKHAQKRRAQQVKMW--AQAEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEA 78
+R + A+ RRA+Q++ W + E+E ++G G +P S +V F V L A
Sbjct: 10 KRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSP----RVRFEDGAVFLAA 65
Query: 79 AARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECW 138
+ D +EVR+ L G + N DGLTALHQ CID+ +MV+ L+E AN+N D+E W
Sbjct: 66 CSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGW 125
Query: 139 TPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQD 198
TPLHAAA+CG+L++ E I GA++ VN++G +P DL ++ D L + +GI
Sbjct: 126 TPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGI--- 182
Query: 199 SIEAARAVPELRMLDDIRSRLQAG--ADLHAPLDHGATLLHVAAANGFSEAAALLLEHRA 256
+E +R E +ML D R L +G D+ GAT LHVAAA G+SE LL++
Sbjct: 183 DLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARS-GATALHVAAAKGYSEVLRLLIQAGY 241
Query: 257 SLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLE 316
L+ +D DGW PLHAAA+WG +L D++ ++ + +TP DV +E + LE
Sbjct: 242 ELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA--DEGLVEHLE 299
Query: 317 LKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQQPP 376
L K +LR++ R+ L + K+ + LY ++ + + ++
Sbjct: 300 LLQKKQNVLRSEKETRNKL----IESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENK 355
Query: 377 PTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPV 420
+S E+ + +E + PE H+ S +
Sbjct: 356 ESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSI 399
>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
sapiens]
Length = 782
Score = 202 bits (515), Expect = 5e-52
Identities = 167/529 (31%), Positives = 241/529 (45%), Gaps = 67/529 (12%)
Query: 26 AQKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEAAARNDLE 85
A++RR +Q++ W A + GPGER + V F + L A A DL+
Sbjct: 18 ARERRREQLRQWGA---RAGAEPGPGERRART---------VRFERAAEFLAACAGGDLD 65
Query: 86 EVRQFL-------GSGVSP----------DLANEDGLTALHQCCIDDFREMVQQLLEAGA 128
E R L G+ + P D N DG++ALHQ CID+ E+V+ L+E GA
Sbjct: 66 EARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGA 125
Query: 129 NINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLET 188
+N D+E WTPLH AA+CG+L + L++ GAN+ AVN+DG++P DL + + L+
Sbjct: 126 TVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKA 185
Query: 189 AMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDH-GATLLHVAAANGFSEA 247
+A RG+ +EAA+ E +L D R L GA A GA+ LHVAAA G+ E
Sbjct: 186 EIARRGV---DVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEV 242
Query: 248 AALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGD 307
LLL+ +D DGW PLHAAA+WG LL HG +++ + + P D+ D
Sbjct: 243 MRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDL-AD 301
Query: 308 EEVRAKLLELKHKHDAL--LRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDLYRKQH 365
EEV + L EL K + L + S+ R + SS+ R V R+S ++ L
Sbjct: 302 EEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISL----- 356
Query: 366 AQEAIVWQQPPPTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPVR---H 422
Q+ ++P P +D D+ + G PPP E V SPV+
Sbjct: 357 -QDLSKERRPGGAGGPPIQDEDEGEEG-PTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEA 414
Query: 423 LYSKR---LDRSVSYQLSPLDSTTPH-----TLVHDKAHHTLADLKRQRAAAKLQRPPPE 474
+S+R L S L P + T L + L Q +L R P
Sbjct: 415 PFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITP- 473
Query: 475 GPESPETAEPGLPGDTVTPQPDCGFRAGGDPPLLKLTAPAVEAPVERRP 523
SP+ EP + + P PP L+ ++P P P
Sbjct: 474 -TPSPKLPEPSVLSEVTKP-----------PPCLENSSPPSRIPEPESP 510
>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 197 bits (501), Expect = 2e-50
Identities = 153/469 (32%), Positives = 232/469 (49%), Gaps = 34/469 (7%)
Query: 22 RLKHAQKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEAAAR 81
++ A+++R +Q+K W +E + + P R++ +V F V L A +
Sbjct: 2 KMADAKQKRNEQLKRWIGSETDLE----PPVVKRQKT-------KVKFDDGAVFLAACSS 50
Query: 82 NDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPL 141
D +EV + L G + AN DGLTALHQ CIDD +MV+ L+E GANIN D+E W PL
Sbjct: 51 GDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPL 110
Query: 142 HAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIE 201
HAAA+CG+L + E LI GA++ AVN++G+ P D+ ++E + L+ + +G+ IE
Sbjct: 111 HAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGV---DIE 167
Query: 202 AARAVPELRMLDDIRSRLQAG--ADL-HAPLDHGATLLHVAAANGFSEAAALLLEHRASL 258
AAR E ML D R L +G D+ HA G T LHVAAA G++E LL++ +
Sbjct: 168 AARKEEERIMLRDARQWLNSGHINDVRHA--KSGGTALHVAAAKGYTEVLKLLIQAGYDV 225
Query: 259 SAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELK 318
+ KD DGW PLHAAA+WG+ +LV + D+ + + +T DV DE++ L EL+
Sbjct: 226 NIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDV-ADEDILGYLEELQ 284
Query: 319 HKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQQPPPT 378
K + L + ++S L T++ + ++ + T + + I +
Sbjct: 285 KKQNLLHSEKRDKKSPLIESTANMDNNQS--QKTFKNKETLIIEPEKNASRIESLEQEKV 342
Query: 379 SPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPVRHLYSKRLDRSVSYQLSP 438
E D+ +E EED+ E + L S + S Q +P
Sbjct: 343 DEEEEGKKDESSCSSE----EDEEDDSE------SEAETDKTKPLASVTNANTSSTQAAP 392
Query: 439 LDSTTPHTLVHDKAHHTLADLKRQRAAAKLQRPPPE-GPESPETAEPGL 486
+ TTP T+ +A T K A K+ E ESP T GL
Sbjct: 393 VAVTTP-TVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGL 440
>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 197 bits (501), Expect = 2e-50
Identities = 153/469 (32%), Positives = 232/469 (49%), Gaps = 34/469 (7%)
Query: 22 RLKHAQKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEAAAR 81
++ A+++R +Q+K W +E + + P R++ +V F V L A +
Sbjct: 2 KMADAKQKRNEQLKRWIGSETDLE----PPVVKRQKT-------KVKFDDGAVFLAACSS 50
Query: 82 NDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPL 141
D +EV + L G + AN DGLTALHQ CIDD +MV+ L+E GANIN D+E W PL
Sbjct: 51 GDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPL 110
Query: 142 HAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIE 201
HAAA+CG+L + E LI GA++ AVN++G+ P D+ ++E + L+ + +G+ IE
Sbjct: 111 HAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGV---DIE 167
Query: 202 AARAVPELRMLDDIRSRLQAG--ADL-HAPLDHGATLLHVAAANGFSEAAALLLEHRASL 258
AAR E ML D R L +G D+ HA G T LHVAAA G++E LL++ +
Sbjct: 168 AARKEEERIMLRDARQWLNSGHINDVRHA--KSGGTALHVAAAKGYTEVLKLLIQAGYDV 225
Query: 259 SAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELK 318
+ KD DGW PLHAAA+WG+ +LV + D+ + + +T DV DE++ L EL+
Sbjct: 226 NIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDV-ADEDILGYLEELQ 284
Query: 319 HKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQQPPPT 378
K + L + ++S L T++ + ++ + T + + I +
Sbjct: 285 KKQNLLHSEKRDKKSPLIESTANMDNNQS--QKTFKNKETLIIEPEKNASRIESLEQEKV 342
Query: 379 SPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPVRHLYSKRLDRSVSYQLSP 438
E D+ +E EED+ E + L S + S Q +P
Sbjct: 343 DEEEEGKKDESSCSSE----EDEEDDSE------SEAETDKTKPLASVTNANTSSTQAAP 392
Query: 439 LDSTTPHTLVHDKAHHTLADLKRQRAAAKLQRPPPE-GPESPETAEPGL 486
+ TTP T+ +A T K A K+ E ESP T GL
Sbjct: 393 VAVTTP-TVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGL 440
>gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]
Length = 1858
Score = 155 bits (392), Expect = 9e-38
Identities = 109/398 (27%), Positives = 193/398 (48%), Gaps = 22/398 (5%)
Query: 21 ERLKHAQKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEAAA 80
+R + ++ R +Q+K + + EK Q ++G +R K A + +V F + +L +A
Sbjct: 15 QRQRLVKRMRCEQIKAYYEREKAFQKQEGFLKR-LKHAKNP----KVHFNLTDMLQDAII 69
Query: 81 RNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTP 140
++ +EV + L G P G + LH C D + + L++ G N+N D + WTP
Sbjct: 70 HHNDKEVLRLLKEGADPHTLVSSGGSLLHLCARYDNAFIAEILIDRGVNVNHQDEDFWTP 129
Query: 141 LHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLC-DDEQTLDCLETAMADRGITQDS 199
+H A C + +V LL+ +GAN+L + +GN+P D + ++ L T + + G+ S
Sbjct: 130 MHIACACDNPDIVLLLVLAGANVLLQDVNGNIPLDYAVEGTESSSILLTYLDENGVDLTS 189
Query: 200 IEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLS 259
+ + + ML D++ L +G +++ D G TLLH+A A+G+ E +L+LEH L+
Sbjct: 190 LRQMKLQRPMSMLTDVKHFLSSGGNVNEKNDEGVTLLHMACASGYKEVVSLILEHGGDLN 249
Query: 260 AKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLL---- 315
D W PLH AA +GQ LV+LL+ H A+ + + +E D+ E + LL
Sbjct: 250 IVDDQYWTPLHLAAKYGQTNLVKLLLMHQANPHLVNCNEEKASDIAASEFIEEMLLKAEI 309
Query: 316 ----ELKHKHDALLRAQSRQRSLLRRRTSSAGSRGK-----VVRRVSLTQRTDLYRKQHA 366
++K A AQ + S+ + ++ SL ++ +++ A
Sbjct: 310 AWEEKMKEPLSASTLAQEEPYEEIIHDLPVLSSKLSPLVLPIAKQDSLLEKDIMFK--DA 367
Query: 367 QEAIVWQQPPPTSPE-PPEDNDDRQTGAELRPPPPEED 403
+ + QQ + PE P + +L PP P +D
Sbjct: 368 TKGLCKQQSQDSIPENPMMSGSTKPEQVKLMPPAPNDD 405
>gi|219842214 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform b [Homo sapiens]
Length = 943
Score = 150 bits (379), Expect = 3e-36
Identities = 121/372 (32%), Positives = 182/372 (48%), Gaps = 23/372 (6%)
Query: 119 MVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCD 178
MV+ L+E GANIN D+E W PLHAAA+CG+L + E LI GA++ AVN++G+ P D+ +
Sbjct: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
Query: 179 DEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAG--ADL-HAPLDHGATL 235
+E + L+ + +G+ IEAAR E ML D R L +G D+ HA G T
Sbjct: 61 EEAMEELLQNEVNRQGV---DIEAARKEEERIMLRDARQWLNSGHINDVRHA--KSGGTA 115
Query: 236 LHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKS 295
LHVAAA G++E LL++ ++ KD DGW PLHAAA+WG+ +LV + D+ +
Sbjct: 116 LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVN 175
Query: 296 LMDETPLDVCGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLT 355
+ +T DV DE++ L EL+ K + L + ++S L T++ + ++
Sbjct: 176 KVGQTAFDV-ADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQS--QKTFKN 232
Query: 356 QRTDLYRKQHAQEAIVWQQPPPTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRV 415
+ T + + I + E D+ +E EED+ E
Sbjct: 233 KETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSE----EDEEDDSE------SEA 282
Query: 416 GGSPVRHLYSKRLDRSVSYQLSPLDSTTPHTLVHDKAHHTLADLKRQRAAAKLQRPPPE- 474
+ L S + S Q +P+ TTP T+ +A T K A K+ E
Sbjct: 283 ETDKTKPLASVTNANTSSTQAAPVAVTTP-TVSSGQATPTSPIKKFPTTATKISPKEEER 341
Query: 475 GPESPETAEPGL 486
ESP T GL
Sbjct: 342 KDESPATWRLGL 353
Score = 62.4 bits (150), Expect = 1e-09
Identities = 36/110 (32%), Positives = 62/110 (56%), Gaps = 5/110 (4%)
Query: 76 LEAAARND----LEEVRQFLGSGVSPDLAN-EDGLTALHQCCIDDFREMVQQLLEAGANI 130
+EAA + + L + RQ+L SG D+ + + G TALH + E+++ L++AG ++
Sbjct: 79 IEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDV 138
Query: 131 NACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDE 180
N D + WTPLHAAA G +L+ + ++ VN G +D+ D++
Sbjct: 139 NIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADED 188
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 116 bits (290), Expect = 6e-26
Identities = 85/263 (32%), Positives = 123/263 (46%), Gaps = 27/263 (10%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA N + V L G ++ GL LH C E+ + L++ GA +N D
Sbjct: 533 AAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWK 592
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
+TPLH AA G + +LL+ GA+ N DGN P DL D T D + D +
Sbjct: 593 FTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDT-DIQDLLRGDAALLD 651
Query: 198 DSIEAARA-VPELRMLDDIRSR-------------------------LQAGADLHAPLDH 231
+ + A V +L D++ R LQ GAD++A
Sbjct: 652 AAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 711
Query: 232 GATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADL 291
G LH AA+ G + AALL+++ A ++A D+ + PLH AA G+ L LL+AHGAD
Sbjct: 712 GLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 771
Query: 292 NAKSLMDETPLDVCGDEEVRAKL 314
K+ +TPLD+ ++V A L
Sbjct: 772 TLKNQEGQTPLDLVSADDVSALL 794
Score = 102 bits (255), Expect = 7e-22
Identities = 74/225 (32%), Positives = 106/225 (47%), Gaps = 8/225 (3%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA + V L +G + ++ GL LH C E+V LL GA+ NA D+
Sbjct: 65 AAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWN 124
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
+TPLH AA G + + +L+ GA NTDG DL D + +
Sbjct: 125 YTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPS-----AKAVLTGEYKKD 179
Query: 198 DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRAS 257
+ +E+AR+ E +M+ + + HA +T LH+AA + LLL+H A
Sbjct: 180 ELLESARSGNEEKMMALL---TPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD 236
Query: 258 LSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPL 302
+ AKD+ PLH A +G + ELLV HGA +NA L TPL
Sbjct: 237 VHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPL 281
Score = 85.5 bits (210), Expect = 1e-16
Identities = 71/267 (26%), Positives = 113/267 (42%), Gaps = 29/267 (10%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA N ++ V+ L G ++ L LH C E+ + L++ GA +NA D
Sbjct: 218 AAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQ 277
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
+TPLH AA+ + + LL++ GA+ +N DL Q + L + Q
Sbjct: 278 FTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337
Query: 198 DSIEA----------------------------ARAVPELRMLDDIRSRLQAGADLHAPL 229
+ EA A A P + L+ GA+++
Sbjct: 338 AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKT 397
Query: 230 DHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGA 289
T LHVA+ ++ ++++H A ++A D G LH AAY G + LL+++G
Sbjct: 398 KEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGC 457
Query: 290 DLNAKSLMDETPLDVCGDEEVRAKLLE 316
D N SL T L + G+E V+ L E
Sbjct: 458 DPNIISLQGFTALQM-GNENVQQLLQE 483
Score = 81.6 bits (200), Expect = 2e-15
Identities = 63/216 (29%), Positives = 99/216 (45%), Gaps = 10/216 (4%)
Query: 91 LGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHL 150
L G + + ++ LT LH ++V+ +++ A +NA D+ T LH AA CGHL
Sbjct: 387 LRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHL 446
Query: 151 HLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELR 210
LL++ G + ++ G + ++ + GI+ + EA R + E
Sbjct: 447 QTCRLLLSYGCDPNIISLQGFTALQMGNENVQ------QLLQEGISLGNSEADRQLLEAA 500
Query: 211 MLDDIRS--RLQAGADLHAPLDHG--ATLLHVAAANGFSEAAALLLEHRASLSAKDQDGW 266
D+ + +L ++ G +T LH AA LL+H A + AKD+ G
Sbjct: 501 KAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGL 560
Query: 267 EPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPL 302
PLH A +G + ELLV HGA +N L TPL
Sbjct: 561 VPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPL 596
Score = 59.7 bits (143), Expect = 6e-09
Identities = 40/115 (34%), Positives = 62/115 (53%), Gaps = 2/115 (1%)
Query: 213 DDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAA 272
D + LQ GA++ A D G LH A + G +E LLL H A +A+D + PLH A
Sbjct: 72 DVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEA 131
Query: 273 AYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELKHKHDALLRA 327
A G++ + +L+ HGA+ ++ T LD+ D +A +L ++K D LL +
Sbjct: 132 AIKGKIDVCIVLLQHGAEPTIRNTDGRTALDL-ADPSAKA-VLTGEYKKDELLES 184
Score = 59.3 bits (142), Expect = 8e-09
Identities = 51/192 (26%), Positives = 83/192 (43%), Gaps = 8/192 (4%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA N+LE L G + ++ GL LH ++ L++ A +NA D
Sbjct: 686 AAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWA 745
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
+TPLH AA G L LL+A GA+ N +G P DL + L AM +
Sbjct: 746 FTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSAL-- 803
Query: 198 DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALL----LE 253
S + + +R L +G + L ++L +++ + FSE ++++ E
Sbjct: 804 PSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGS--FSELSSVVSSSGTE 861
Query: 254 HRASLSAKDQDG 265
+SL K+ G
Sbjct: 862 GASSLEKKEVPG 873
Score = 55.1 bits (131), Expect = 2e-07
Identities = 29/70 (41%), Positives = 41/70 (58%)
Query: 233 ATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLN 292
+T LH AA G + LL++ A++ A+D G PLH A +G +V LL+ HGAD N
Sbjct: 59 STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118
Query: 293 AKSLMDETPL 302
A+ + TPL
Sbjct: 119 ARDNWNYTPL 128
Score = 53.1 bits (126), Expect = 6e-07
Identities = 73/314 (23%), Positives = 114/314 (36%), Gaps = 90/314 (28%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALH------------------------- 109
L EAA + ++ L G P + N DG TAL
Sbjct: 128 LHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARS 187
Query: 110 ---------------QCCIDDFR--------------EMVQQLLEAGANINACDSECWTP 140
C D R ++VQ LL+ GA+++A D P
Sbjct: 188 GNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVP 247
Query: 141 LHAAATCGHLHLVELLIASGANLLAVNTDGNMP---------YDLCD-------DEQTLD 184
LH A + GH + ELL+ GA + A++ P ++C D L+
Sbjct: 248 LHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLN 307
Query: 185 CLETAMADRGIT-------------QDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDH 231
C + D T ++AAR R+ + + + P H
Sbjct: 308 CHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM---VNFKHPQTH 364
Query: 232 GATLLHVAAANGF---SEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHG 288
T LH AAA+ + + LLL A+++ K ++ PLH A+ +VE++V H
Sbjct: 365 -ETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHE 423
Query: 289 ADLNAKSLMDETPL 302
A +NA + +T L
Sbjct: 424 AKVNALDNLGQTSL 437
Score = 52.8 bits (125), Expect = 8e-07
Identities = 72/258 (27%), Positives = 104/258 (40%), Gaps = 35/258 (13%)
Query: 100 ANEDGLTALHQCCIDDFREMVQQLLEAGANINACDS--ECWTPLHAAATCGHLHLVELLI 157
A E L + C + E V++L+ +N+ D+ TPLH AA G +VE L+
Sbjct: 20 AVEPAARELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLL 78
Query: 158 ASGANLLAVNTDGNMP-YDLCD---------------DEQTLDCLETAMADRGITQDSIE 201
+GAN+ A + G +P ++ C D D + I+
Sbjct: 79 QNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKID 138
Query: 202 AA------RAVPELRMLDDIRSRLQAGADLHAPLD---HGATLLHVAAANGFSEAAALLL 252
A P +R D + A A L LL A + + ALL
Sbjct: 139 VCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLT 198
Query: 253 EHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPL-DVC--GDEE 309
+ A D PLH AA + +V +V+LL+ HGAD++AK D PL + C G E
Sbjct: 199 PLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYE 258
Query: 310 VRAKLLELKHKHDALLRA 327
V EL KH A + A
Sbjct: 259 V----TELLVKHGACVNA 272
Score = 47.0 bits (110), Expect = 4e-05
Identities = 56/218 (25%), Positives = 83/218 (38%), Gaps = 54/218 (24%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGA------ 128
L EAAA+ E + L G P N DG T L + D +Q LL A
Sbjct: 596 LHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLD--LVKDGDTDIQDLLRGDAALLDAA 653
Query: 129 ---------------NINACDSE--CWTPLHAAATCGHLHLVELLIASGANLLAVNTDGN 171
N+N D++ TPLH AA +L + E L+ GA++ A + G
Sbjct: 654 KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGL 713
Query: 172 MPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDH 231
+P + ++ A + ++ A ++A
Sbjct: 714 IP-----------------LHNAASYGHVDVAALL------------IKYNACVNATDKW 744
Query: 232 GATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPL 269
T LH AA G ++ ALLL H A + K+Q+G PL
Sbjct: 745 AFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL 782
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 114 bits (284), Expect = 3e-25
Identities = 82/265 (30%), Positives = 125/265 (47%), Gaps = 27/265 (10%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA N + V L G ++ GL LH C E+ + L+ GA++N D
Sbjct: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
+TPLH AA G + +LL+ GA+ N DGN P DL + T D + D +
Sbjct: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDT-DIQDLLRGDAALLD 809
Query: 198 DSIEAARA-VPELRMLDDIRSR-------------------------LQAGADLHAPLDH 231
+ + A V +L ++I R L+ GAD++A
Sbjct: 810 AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869
Query: 232 GATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADL 291
G LH AA+ G + AALL+++ ++A D+ + PLH AA G+ L LL+AHGAD
Sbjct: 870 GLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 929
Query: 292 NAKSLMDETPLDVCGDEEVRAKLLE 316
K+ +TPLD+ +++RA L++
Sbjct: 930 TMKNQEGQTPLDLATADDIRALLID 954
Score = 103 bits (257), Expect = 4e-22
Identities = 80/249 (32%), Positives = 113/249 (45%), Gaps = 9/249 (3%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA + V L G + ++ GL LH C E+V LL GA+ NA D+
Sbjct: 223 AAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWN 282
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
+TPLH AA G + + +L+ GA+ NTDG DL D + +
Sbjct: 283 YTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPS-----AKAVLTGEYKKD 337
Query: 198 DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRAS 257
+ +EAAR+ E +++ + + HA +T LH+AA LLL+H A
Sbjct: 338 ELLEAARSGNEEKLMALL---TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGAD 394
Query: 258 LSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPL-DVCGDEEVRAKLLE 316
+ AKD+ G PLH A +G + ELL+ HGA +NA L TPL + V L
Sbjct: 395 VHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 454
Query: 317 LKHKHDALL 325
L H D L
Sbjct: 455 LSHGADPTL 463
Score = 82.8 bits (203), Expect = 7e-16
Identities = 73/237 (30%), Positives = 109/237 (45%), Gaps = 11/237 (4%)
Query: 91 LGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHL 150
L G + + N+D +T LH ++++ L + GA +NA D+ T LH AA GHL
Sbjct: 545 LRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHL 604
Query: 151 HLVELLIASGANLLAVNTDGNMPYDLCDDE-QTLDCLETAMADRGITQDSIEAARAVPEL 209
LL++ G++ ++ G + ++ Q + T + + +EA++A +L
Sbjct: 605 QTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKA-GDL 663
Query: 210 RMLDDIRSRLQAGA-DLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEP 268
+ + S DL +T LH AA LL H A + AKD+ G P
Sbjct: 664 ETVKQLCSSQNVNCRDLEG---RHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVP 720
Query: 269 LHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVC---GDEEVRAKLLELKHKHD 322
LH A +G + ELLV HGA +N L TPL G E+ KLL LKH D
Sbjct: 721 LHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEI-CKLL-LKHGAD 775
Score = 68.6 bits (166), Expect = 1e-11
Identities = 71/266 (26%), Positives = 106/266 (39%), Gaps = 39/266 (14%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA N + V+ L G ++ GL LH C E+ + LL+ GA +NA D
Sbjct: 376 AAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQ 435
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
+TPLH AA+ + + LL++ GA+ VN G D+ + + L + Q
Sbjct: 436 FTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQ 495
Query: 198 DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRAS 257
+ EA A + + +I + Q P H T LH A A S
Sbjct: 496 AAREADLAKVKKTLALEIINFKQ-------PQSH-ETALHCAVA---------------S 532
Query: 258 LSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLEL 317
L K + + ELL+ GA++N K+ TPL V E ++E+
Sbjct: 533 LHPKRKQ---------------VTELLLRKGANVNEKNKDFMTPLHVAA-ERAHNDVMEV 576
Query: 318 KHKHDALLRAQSRQRSLLRRRTSSAG 343
HKH A + A R + AG
Sbjct: 577 LHKHGAKMNALDTLGQTALHRAALAG 602
Score = 63.9 bits (154), Expect = 3e-10
Identities = 42/115 (36%), Positives = 65/115 (56%), Gaps = 2/115 (1%)
Query: 213 DDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAA 272
D + LQ GA++HA D G LH A + G +E +LLL A +A+D + PLH A
Sbjct: 230 DVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEA 289
Query: 273 AYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELKHKHDALLRA 327
A G++ + +L+ HGAD N ++ ++ LD+ D +A +L ++K D LL A
Sbjct: 290 AIKGKIDVCIVLLQHGADPNIRNTDGKSALDL-ADPSAKA-VLTGEYKKDELLEA 342
Score = 55.8 bits (133), Expect = 9e-08
Identities = 36/113 (31%), Positives = 50/113 (44%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA N+LE L G + ++ GL LH ++ L++ +NA D
Sbjct: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWA 903
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAM 190
+TPLH AA G L LL+A GA+ N +G P DL + L AM
Sbjct: 904 FTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAM 956
Score = 53.9 bits (128), Expect = 4e-07
Identities = 71/256 (27%), Positives = 105/256 (41%), Gaps = 32/256 (12%)
Query: 92 GSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD--SECWTPLHAAATCGH 149
G+GV A L L + C + V++L++A AN+NA D +PLH AA G
Sbjct: 173 GTGVP---AVSGALRELLEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGR 228
Query: 150 LHLVELLIASGANLLAVNTDGNMP-YDLCD--DEQTLDCLETAMADRGITQD-SIEAARA 205
+VE L+ GAN+ A + G +P ++ C + + L AD + +
Sbjct: 229 KDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHE 288
Query: 206 VPELRMLDDIRSRLQAGADLHAPLDHGAT---------------------LLHVAAANGF 244
+D LQ GAD + G + LL A +
Sbjct: 289 AAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNE 348
Query: 245 SEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPL-D 303
+ ALL + A D PLH AA + +V +V+LL+ HGAD++AK PL +
Sbjct: 349 EKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHN 408
Query: 304 VCGDEEVRAKLLELKH 319
C L LKH
Sbjct: 409 ACSYGHYEVTELLLKH 424
Score = 31.6 bits (70), Expect = 1.9
Identities = 32/100 (32%), Positives = 48/100 (48%), Gaps = 5/100 (5%)
Query: 221 AGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWE--PLHAAAYWGQV 278
AG P GA + A + L A+++AKD G + PLH AA +G+
Sbjct: 170 AGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRK 229
Query: 279 PLVELLVAHGADLNAKSLMDETPL-DVC--GDEEVRAKLL 315
+VE L+ GA+++A+ PL + C G EV + LL
Sbjct: 230 DVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLL 269
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 103 bits (258), Expect = 3e-22
Identities = 84/311 (27%), Positives = 146/311 (46%), Gaps = 31/311 (9%)
Query: 27 QKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEAAARNDLEE 86
+K R ++ + EK+ + +K +R +K A+ L+ AA LE+
Sbjct: 9 KKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLR------------AARAGHLEK 56
Query: 87 VRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAAT 146
++ +GV ++ N++GL ALH + E+V +LL+ AN++A + T LH A+
Sbjct: 57 ALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASL 116
Query: 147 CGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAV 206
G +V++L+ +GAN+ A + +G P + E L+ ++ + D G +Q
Sbjct: 117 AGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVK-FLLDNGASQSLATEDGFT 175
Query: 207 PELRMLDDIRSRLQAGADLHAPL--------DHGATLLHVAAANGFSEAAALLLEHRASL 258
P + LQ G D L LH+AA ++AAALLL++ +
Sbjct: 176 P-------LAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNA 228
Query: 259 SAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVC---GDEEVRAKLL 315
+ + G+ PLH AA++G + + LL+ A ++ + D TPL V G+ + LL
Sbjct: 229 DVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLL 288
Query: 316 ELKHKHDALLR 326
+ K DA R
Sbjct: 289 DRGAKIDAKTR 299
Score = 101 bits (251), Expect = 2e-21
Identities = 69/248 (27%), Positives = 118/248 (47%), Gaps = 5/248 (2%)
Query: 87 VRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAAT 146
V+Q L G SP+ A G T LH + ++ LL+ GA+++ + +TPLH AA
Sbjct: 515 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK 574
Query: 147 CGHLHLVELLIASGANLLAVNTDGNMPYDLC----DDEQTLDCLETAMADRGITQDSIEA 202
G L + LL+ A+ A G P + + + L L+ + ++
Sbjct: 575 YGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTP 634
Query: 203 ARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKD 262
+ +D + L+ GAD +A G +H+AA G + +LLL A+++ +
Sbjct: 635 LHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSN 694
Query: 263 QDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELKHKHD 322
+ G PLH AA +V + E+LV GA ++A++ M TPL V G K++ +H
Sbjct: 695 KSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHV-GCHYGNIKIVNFLLQHS 753
Query: 323 ALLRAQSR 330
A + A+++
Sbjct: 754 AKVNAKTK 761
Score = 95.9 bits (237), Expect = 8e-20
Identities = 69/246 (28%), Positives = 109/246 (44%), Gaps = 7/246 (2%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA ++ L + D + +T LH MV+ LL+ GA I+A +
Sbjct: 242 AAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDG 301
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADR---- 193
TPLH A GH +VE+L+ A +L+ +G P + L+C++ +
Sbjct: 302 LTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD 361
Query: 194 GITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLE 253
+T D + A + L A+ +A +G T LH+A + LLL+
Sbjct: 362 DVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLK 421
Query: 254 HRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVC---GDEEV 310
H AS+ A + G P+H AA+ G V +V L+ HGA N ++ ET L + G EV
Sbjct: 422 HGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEV 481
Query: 311 RAKLLE 316
L++
Sbjct: 482 VRYLVQ 487
Score = 95.5 bits (236), Expect = 1e-19
Identities = 65/218 (29%), Positives = 101/218 (46%), Gaps = 4/218 (1%)
Query: 91 LGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHL 150
L +P+ +G T LH C + ++++ LL+ GA+I A TP+H AA GH+
Sbjct: 387 LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHV 446
Query: 151 HLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMAD----RGITQDSIEAARAV 206
++V L+ GA+ N G + + + + D +D
Sbjct: 447 NIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHIS 506
Query: 207 PELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGW 266
L D ++ LQ GA +A G T LH++A G + AA LL+H ASLS + G+
Sbjct: 507 ARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGF 566
Query: 267 EPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDV 304
PLH AA +G++ + LL+ A +A TPL V
Sbjct: 567 TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604
Score = 93.2 bits (230), Expect = 5e-19
Identities = 68/249 (27%), Positives = 117/249 (46%), Gaps = 8/249 (3%)
Query: 76 LEAAARNDLEEVRQFLGSGVSPDLAN-EDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AR+ E+V + L +P L+ ++GL+ LH D VQ LL+ ++
Sbjct: 305 LHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVT 364
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMAD-- 192
++ T LH AA CGH + ++L+ AN A +G P + + + +E +
Sbjct: 365 NDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGA 424
Query: 193 --RGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAAL 250
+ +T+ + + ++ + + GA + G T LH+AA +G +E
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVC---GD 307
L++ A + AK +D PLH +A G+ +V+ L+ GA NA + TPL + G
Sbjct: 485 LVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGH 544
Query: 308 EEVRAKLLE 316
E+V A LL+
Sbjct: 545 EDVAAFLLD 553
Score = 91.7 bits (226), Expect = 2e-18
Identities = 71/221 (32%), Positives = 99/221 (44%), Gaps = 6/221 (2%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA + V Q + G SP+ N G TALH E+V+ L++ GA + A +
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRG--- 194
TPLH +A G +V+ L+ GA+ A T G P L E D + + D G
Sbjct: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHED-VAAFLLDHGASL 558
Query: 195 --ITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLL 252
T+ + L+ LQ A A G T LHVAA + A LLL
Sbjct: 559 SITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLL 618
Query: 253 EHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNA 293
+ AS A ++G+ PLH AA Q+ + L+ +GAD NA
Sbjct: 619 DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANA 659
Score = 89.4 bits (220), Expect = 8e-18
Identities = 77/278 (27%), Positives = 122/278 (43%), Gaps = 13/278 (4%)
Query: 38 AQAEKEAQGKKGP---GERPRKEAASQGLLKQVLFPPSVVL-----LEAAARNDLEEVRQ 89
AQ E +A+ + P R K Q LL+Q P + L +AR E+V
Sbjct: 490 AQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAA 549
Query: 90 FL-GSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCG 148
FL G S + + G T LH E+ LL+ A+ +A TPLH AA
Sbjct: 550 FLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYD 609
Query: 149 HLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAM---AD-RGITQDSIEAAR 204
+ + LL+ GA+ A +G P + + +D T + AD +T+ I +
Sbjct: 610 NQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVH 669
Query: 205 AVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQD 264
+ +D + L A+++ G T LH+AA A +L+ A + A+ +
Sbjct: 670 LAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729
Query: 265 GWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPL 302
G+ PLH ++G + +V L+ H A +NAK+ TPL
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPL 767
Score = 87.8 bits (216), Expect = 2e-17
Identities = 65/231 (28%), Positives = 100/231 (43%), Gaps = 4/231 (1%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA LE L SPD A + GLT LH D +++ LL+ GA+ +A
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
+TPLH AA + + L+ GA+ AV G L E +D + +
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691
Query: 198 DSIEAARAVPELRMLDD----IRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLE 253
S ++ L +D + GA + A G T LHV G + LL+
Sbjct: 692 LSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ 751
Query: 254 HRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDV 304
H A ++AK ++G+ PLH AA G ++ +L+ + A N ++ T L +
Sbjct: 752 HSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGI 802
Score = 51.6 bits (122), Expect = 2e-06
Identities = 32/97 (32%), Positives = 48/97 (49%), Gaps = 1/97 (1%)
Query: 76 LEAAARNDLEEVRQFL-GSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AA+ D V + L G D + G T LH C ++V LL+ A +NA
Sbjct: 701 LHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKT 760
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGN 171
+TPLH AA GH H++ +L+ + A+ + +GN
Sbjct: 761 KNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGN 797
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 100 bits (249), Expect = 3e-21
Identities = 77/260 (29%), Positives = 120/260 (46%), Gaps = 6/260 (2%)
Query: 76 LEAAAR-NDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AAR V+ L + +P+LA G T LH + E V LLE A+
Sbjct: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 566
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRG 194
+ +TPLH AA G + + ELL+ A+ A +G P + LD ++ + G
Sbjct: 567 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 626
Query: 195 ITQ----DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAAL 250
+ + ++ RS LQ G +A G T LH+AA G +E AL
Sbjct: 627 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 686
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEV 310
LL +A+ + ++ G PLH A G VP+ ++L+ HG ++A + M TPL V
Sbjct: 687 LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHV-ASHYG 745
Query: 311 RAKLLELKHKHDALLRAQSR 330
KL++ +H A + A+++
Sbjct: 746 NIKLVKFLLQHQADVNAKTK 765
Score = 95.1 bits (235), Expect = 1e-19
Identities = 71/250 (28%), Positives = 118/250 (47%), Gaps = 5/250 (2%)
Query: 76 LEAAARNDLEEVRQFLGSGVSPDLAN-EDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AARN + + L +P A ++GL+ +H D + V+ LL+ A I+
Sbjct: 309 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 368
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLE----TAM 190
+ TPLH AA CGH + ++L+ GA + +G P + + + +E T
Sbjct: 369 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA 428
Query: 191 ADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAAL 250
+ +T+ + + L +++ LQ GA + T LH+AA G +E A
Sbjct: 429 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 488
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEV 310
LL+++A ++AK +D PLH AA G +V+LL+ + A+ N + TPL + E
Sbjct: 489 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 548
Query: 311 RAKLLELKHK 320
+L L K
Sbjct: 549 VETVLALLEK 558
Score = 87.0 bits (214), Expect = 4e-17
Identities = 87/339 (25%), Positives = 149/339 (43%), Gaps = 46/339 (13%)
Query: 31 AQQVKMWAQAEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEAAARNDLEEVRQF 90
A+Q+K E +A ++ E ++ ++ ++ + L AA +L++
Sbjct: 5 AKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDH 64
Query: 91 LGSGVSPDLANEDGL---------------------------------TALHQCCIDDFR 117
L +GV + N++GL TALH +
Sbjct: 65 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 124
Query: 118 EMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLC 177
E+V++L+ GAN+NA + +TPL+ AA HL +V+ L+ +GAN DG P +
Sbjct: 125 EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 184
Query: 178 DDEQTLDCLETAMADRGITQDSIEAARAVPELRML---DDIRSR---LQAGADLHAPLDH 231
+Q + + + + G T+ + +P L + DD R+ LQ +
Sbjct: 185 -LQQGHENVVAHLINYG-TKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKT 238
Query: 232 GATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADL 291
G T LH+AA A LLL AS++ Q+G PLH A+ G V +V LL+ GA +
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 298
Query: 292 NAKSLMDETPLDVCGDEEVRAKLLELKHKHDALLRAQSR 330
K+ + TPL C ++ E+ H A ++A+++
Sbjct: 299 ETKTKDELTPLH-CAARNGHVRISEILLDHGAPIQAKTK 336
Score = 85.1 bits (209), Expect = 1e-16
Identities = 71/227 (31%), Positives = 100/227 (44%), Gaps = 29/227 (12%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
A N+L+ V+ L G SP +G T LH + E+ + LL+ G + NA +
Sbjct: 609 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 668
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
TPLH AA GH +V LL++ AN N G P L E
Sbjct: 669 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH--------------- 713
Query: 198 DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRAS 257
VP +L ++ G + A G T LHVA+ G + LL+H+A
Sbjct: 714 --------VPVADVL------IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD 759
Query: 258 LSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDV 304
++AK + G+ PLH AA G +V LL+ +GA N S TPL +
Sbjct: 760 VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAI 806
Score = 82.8 bits (203), Expect = 7e-16
Identities = 74/275 (26%), Positives = 115/275 (41%), Gaps = 36/275 (13%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA E VR+ + G + + ++ G T L+ ++ E+V+ LLE GAN N +
Sbjct: 118 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 177
Query: 138 WTPLHAAATCGHLHLVELLIASGA---------NLLAVNTDGNMPYDLCDDEQTLDCLET 188
+TPL A GH ++V LI G ++ A N D L ++ D L
Sbjct: 178 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 237
Query: 189 A-------------------MADRGIT-----QDSIEAARAVPELRMLDDIRSRLQAGAD 224
+ +RG + Q+ I + +R L GA
Sbjct: 238 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 297
Query: 225 LHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELL 284
+ T LH AA NG + +LL+H A + AK ++G P+H AA + V LL
Sbjct: 298 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 357
Query: 285 VAHGADLNAKSLMDETPLDV---CGDEEVRAKLLE 316
+ + A+++ +L TPL V CG V LL+
Sbjct: 358 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 392
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 100 bits (249), Expect = 3e-21
Identities = 77/260 (29%), Positives = 120/260 (46%), Gaps = 6/260 (2%)
Query: 76 LEAAAR-NDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AAR V+ L + +P+LA G T LH + E V LLE A+
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRG 194
+ +TPLH AA G + + ELL+ A+ A +G P + LD ++ + G
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 195 ITQ----DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAAL 250
+ + ++ RS LQ G +A G T LH+AA G +E AL
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEV 310
LL +A+ + ++ G PLH A G VP+ ++L+ HG ++A + M TPL V
Sbjct: 654 LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHV-ASHYG 712
Query: 311 RAKLLELKHKHDALLRAQSR 330
KL++ +H A + A+++
Sbjct: 713 NIKLVKFLLQHQADVNAKTK 732
Score = 95.1 bits (235), Expect = 1e-19
Identities = 71/250 (28%), Positives = 118/250 (47%), Gaps = 5/250 (2%)
Query: 76 LEAAARNDLEEVRQFLGSGVSPDLAN-EDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AARN + + L +P A ++GL+ +H D + V+ LL+ A I+
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLE----TAM 190
+ TPLH AA CGH + ++L+ GA + +G P + + + +E T
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA 395
Query: 191 ADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAAL 250
+ +T+ + + L +++ LQ GA + T LH+AA G +E A
Sbjct: 396 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEV 310
LL+++A ++AK +D PLH AA G +V+LL+ + A+ N + TPL + E
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Query: 311 RAKLLELKHK 320
+L L K
Sbjct: 516 VETVLALLEK 525
Score = 85.1 bits (209), Expect = 1e-16
Identities = 71/227 (31%), Positives = 100/227 (44%), Gaps = 29/227 (12%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
A N+L+ V+ L G SP +G T LH + E+ + LL+ G + NA +
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
TPLH AA GH +V LL++ AN N G P L E
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH--------------- 680
Query: 198 DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRAS 257
VP +L ++ G + A G T LHVA+ G + LL+H+A
Sbjct: 681 --------VPVADVL------IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD 726
Query: 258 LSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDV 304
++AK + G+ PLH AA G +V LL+ +GA N S TPL +
Sbjct: 727 VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAI 773
Score = 84.0 bits (206), Expect = 3e-16
Identities = 81/294 (27%), Positives = 131/294 (44%), Gaps = 46/294 (15%)
Query: 76 LEAAARNDLEEVRQFLGSGVSPDLANEDGL------------------------------ 105
L AA +L++ L +GV + N++GL
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 106 ---TALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGAN 162
TALH + E+V++L+ GAN+NA + +TPL+ AA HL +V+ L+ +GAN
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 163 LLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRML---DDIRSR- 218
DG P + +Q + + + + G T+ + +P L + DD R+
Sbjct: 137 QNVATEDGFTPLAVA-LQQGHENVVAHLINYG-TKGKVR----LPALHIAARNDDTRTAA 190
Query: 219 --LQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWG 276
LQ + G T LH+AA A LLL AS++ Q+G PLH A+ G
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 277 QVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELKHKHDALLRAQSR 330
V +V LL+ GA + K+ + TPL C ++ E+ H A ++A+++
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDELTPLH-CAARNGHVRISEILLDHGAPIQAKTK 303
Score = 82.8 bits (203), Expect = 7e-16
Identities = 74/275 (26%), Positives = 115/275 (41%), Gaps = 36/275 (13%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA E VR+ + G + + ++ G T L+ ++ E+V+ LLE GAN N +
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 138 WTPLHAAATCGHLHLVELLIASGA---------NLLAVNTDGNMPYDLCDDEQTLDCLET 188
+TPL A GH ++V LI G ++ A N D L ++ D L
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 189 A-------------------MADRGIT-----QDSIEAARAVPELRMLDDIRSRLQAGAD 224
+ +RG + Q+ I + +R L GA
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 225 LHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELL 284
+ T LH AA NG + +LL+H A + AK ++G P+H AA + V LL
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Query: 285 VAHGADLNAKSLMDETPLDV---CGDEEVRAKLLE 316
+ + A+++ +L TPL V CG V LL+
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 100 bits (249), Expect = 3e-21
Identities = 77/260 (29%), Positives = 120/260 (46%), Gaps = 6/260 (2%)
Query: 76 LEAAAR-NDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AAR V+ L + +P+LA G T LH + E V LLE A+
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRG 194
+ +TPLH AA G + + ELL+ A+ A +G P + LD ++ + G
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 195 ITQ----DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAAL 250
+ + ++ RS LQ G +A G T LH+AA G +E AL
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEV 310
LL +A+ + ++ G PLH A G VP+ ++L+ HG ++A + M TPL V
Sbjct: 654 LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHV-ASHYG 712
Query: 311 RAKLLELKHKHDALLRAQSR 330
KL++ +H A + A+++
Sbjct: 713 NIKLVKFLLQHQADVNAKTK 732
Score = 95.1 bits (235), Expect = 1e-19
Identities = 71/250 (28%), Positives = 118/250 (47%), Gaps = 5/250 (2%)
Query: 76 LEAAARNDLEEVRQFLGSGVSPDLAN-EDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AARN + + L +P A ++GL+ +H D + V+ LL+ A I+
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLE----TAM 190
+ TPLH AA CGH + ++L+ GA + +G P + + + +E T
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA 395
Query: 191 ADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAAL 250
+ +T+ + + L +++ LQ GA + T LH+AA G +E A
Sbjct: 396 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEV 310
LL+++A ++AK +D PLH AA G +V+LL+ + A+ N + TPL + E
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Query: 311 RAKLLELKHK 320
+L L K
Sbjct: 516 VETVLALLEK 525
Score = 85.1 bits (209), Expect = 1e-16
Identities = 71/227 (31%), Positives = 100/227 (44%), Gaps = 29/227 (12%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
A N+L+ V+ L G SP +G T LH + E+ + LL+ G + NA +
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
TPLH AA GH +V LL++ AN N G P L E
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH--------------- 680
Query: 198 DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRAS 257
VP +L ++ G + A G T LHVA+ G + LL+H+A
Sbjct: 681 --------VPVADVL------IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD 726
Query: 258 LSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDV 304
++AK + G+ PLH AA G +V LL+ +GA N S TPL +
Sbjct: 727 VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAI 773
Score = 84.0 bits (206), Expect = 3e-16
Identities = 81/294 (27%), Positives = 131/294 (44%), Gaps = 46/294 (15%)
Query: 76 LEAAARNDLEEVRQFLGSGVSPDLANEDGL------------------------------ 105
L AA +L++ L +GV + N++GL
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 106 ---TALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGAN 162
TALH + E+V++L+ GAN+NA + +TPL+ AA HL +V+ L+ +GAN
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 163 LLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRML---DDIRSR- 218
DG P + +Q + + + + G T+ + +P L + DD R+
Sbjct: 137 QNVATEDGFTPLAVA-LQQGHENVVAHLINYG-TKGKVR----LPALHIAARNDDTRTAA 190
Query: 219 --LQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWG 276
LQ + G T LH+AA A LLL AS++ Q+G PLH A+ G
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 277 QVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELKHKHDALLRAQSR 330
V +V LL+ GA + K+ + TPL C ++ E+ H A ++A+++
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDELTPLH-CAARNGHVRISEILLDHGAPIQAKTK 303
Score = 82.8 bits (203), Expect = 7e-16
Identities = 74/275 (26%), Positives = 115/275 (41%), Gaps = 36/275 (13%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA E VR+ + G + + ++ G T L+ ++ E+V+ LLE GAN N +
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 138 WTPLHAAATCGHLHLVELLIASGA---------NLLAVNTDGNMPYDLCDDEQTLDCLET 188
+TPL A GH ++V LI G ++ A N D L ++ D L
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 189 A-------------------MADRGIT-----QDSIEAARAVPELRMLDDIRSRLQAGAD 224
+ +RG + Q+ I + +R L GA
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 225 LHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELL 284
+ T LH AA NG + +LL+H A + AK ++G P+H AA + V LL
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Query: 285 VAHGADLNAKSLMDETPLDV---CGDEEVRAKLLE 316
+ + A+++ +L TPL V CG V LL+
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 100 bits (249), Expect = 3e-21
Identities = 77/260 (29%), Positives = 120/260 (46%), Gaps = 6/260 (2%)
Query: 76 LEAAAR-NDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AAR V+ L + +P+LA G T LH + E V LLE A+
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRG 194
+ +TPLH AA G + + ELL+ A+ A +G P + LD ++ + G
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 195 ITQ----DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAAL 250
+ + ++ RS LQ G +A G T LH+AA G +E AL
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEV 310
LL +A+ + ++ G PLH A G VP+ ++L+ HG ++A + M TPL V
Sbjct: 654 LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHV-ASHYG 712
Query: 311 RAKLLELKHKHDALLRAQSR 330
KL++ +H A + A+++
Sbjct: 713 NIKLVKFLLQHQADVNAKTK 732
Score = 95.1 bits (235), Expect = 1e-19
Identities = 71/250 (28%), Positives = 118/250 (47%), Gaps = 5/250 (2%)
Query: 76 LEAAARNDLEEVRQFLGSGVSPDLAN-EDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AARN + + L +P A ++GL+ +H D + V+ LL+ A I+
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLE----TAM 190
+ TPLH AA CGH + ++L+ GA + +G P + + + +E T
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA 395
Query: 191 ADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAAL 250
+ +T+ + + L +++ LQ GA + T LH+AA G +E A
Sbjct: 396 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEV 310
LL+++A ++AK +D PLH AA G +V+LL+ + A+ N + TPL + E
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Query: 311 RAKLLELKHK 320
+L L K
Sbjct: 516 VETVLALLEK 525
Score = 85.1 bits (209), Expect = 1e-16
Identities = 71/227 (31%), Positives = 100/227 (44%), Gaps = 29/227 (12%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
A N+L+ V+ L G SP +G T LH + E+ + LL+ G + NA +
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
TPLH AA GH +V LL++ AN N G P L E
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH--------------- 680
Query: 198 DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRAS 257
VP +L ++ G + A G T LHVA+ G + LL+H+A
Sbjct: 681 --------VPVADVL------IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD 726
Query: 258 LSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDV 304
++AK + G+ PLH AA G +V LL+ +GA N S TPL +
Sbjct: 727 VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAI 773
Score = 84.0 bits (206), Expect = 3e-16
Identities = 81/294 (27%), Positives = 131/294 (44%), Gaps = 46/294 (15%)
Query: 76 LEAAARNDLEEVRQFLGSGVSPDLANEDGL------------------------------ 105
L AA +L++ L +GV + N++GL
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 106 ---TALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGAN 162
TALH + E+V++L+ GAN+NA + +TPL+ AA HL +V+ L+ +GAN
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 163 LLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRML---DDIRSR- 218
DG P + +Q + + + + G T+ + +P L + DD R+
Sbjct: 137 QNVATEDGFTPLAVA-LQQGHENVVAHLINYG-TKGKVR----LPALHIAARNDDTRTAA 190
Query: 219 --LQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWG 276
LQ + G T LH+AA A LLL AS++ Q+G PLH A+ G
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 277 QVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELKHKHDALLRAQSR 330
V +V LL+ GA + K+ + TPL C ++ E+ H A ++A+++
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDELTPLH-CAARNGHVRISEILLDHGAPIQAKTK 303
Score = 82.8 bits (203), Expect = 7e-16
Identities = 74/275 (26%), Positives = 115/275 (41%), Gaps = 36/275 (13%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA E VR+ + G + + ++ G T L+ ++ E+V+ LLE GAN N +
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 138 WTPLHAAATCGHLHLVELLIASGA---------NLLAVNTDGNMPYDLCDDEQTLDCLET 188
+TPL A GH ++V LI G ++ A N D L ++ D L
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 189 A-------------------MADRGIT-----QDSIEAARAVPELRMLDDIRSRLQAGAD 224
+ +RG + Q+ I + +R L GA
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 225 LHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELL 284
+ T LH AA NG + +LL+H A + AK ++G P+H AA + V LL
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Query: 285 VAHGADLNAKSLMDETPLDV---CGDEEVRAKLLE 316
+ + A+++ +L TPL V CG V LL+
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 100 bits (249), Expect = 3e-21
Identities = 77/260 (29%), Positives = 120/260 (46%), Gaps = 6/260 (2%)
Query: 76 LEAAAR-NDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AAR V+ L + +P+LA G T LH + E V LLE A+
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRG 194
+ +TPLH AA G + + ELL+ A+ A +G P + LD ++ + G
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 195 ITQ----DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAAL 250
+ + ++ RS LQ G +A G T LH+AA G +E AL
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEV 310
LL +A+ + ++ G PLH A G VP+ ++L+ HG ++A + M TPL V
Sbjct: 654 LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHV-ASHYG 712
Query: 311 RAKLLELKHKHDALLRAQSR 330
KL++ +H A + A+++
Sbjct: 713 NIKLVKFLLQHQADVNAKTK 732
Score = 95.1 bits (235), Expect = 1e-19
Identities = 71/250 (28%), Positives = 118/250 (47%), Gaps = 5/250 (2%)
Query: 76 LEAAARNDLEEVRQFLGSGVSPDLAN-EDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AARN + + L +P A ++GL+ +H D + V+ LL+ A I+
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLE----TAM 190
+ TPLH AA CGH + ++L+ GA + +G P + + + +E T
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA 395
Query: 191 ADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAAL 250
+ +T+ + + L +++ LQ GA + T LH+AA G +E A
Sbjct: 396 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEV 310
LL+++A ++AK +D PLH AA G +V+LL+ + A+ N + TPL + E
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Query: 311 RAKLLELKHK 320
+L L K
Sbjct: 516 VETVLALLEK 525
Score = 85.1 bits (209), Expect = 1e-16
Identities = 71/227 (31%), Positives = 100/227 (44%), Gaps = 29/227 (12%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
A N+L+ V+ L G SP +G T LH + E+ + LL+ G + NA +
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
TPLH AA GH +V LL++ AN N G P L E
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH--------------- 680
Query: 198 DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRAS 257
VP +L ++ G + A G T LHVA+ G + LL+H+A
Sbjct: 681 --------VPVADVL------IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD 726
Query: 258 LSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDV 304
++AK + G+ PLH AA G +V LL+ +GA N S TPL +
Sbjct: 727 VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAI 773
Score = 84.0 bits (206), Expect = 3e-16
Identities = 81/294 (27%), Positives = 131/294 (44%), Gaps = 46/294 (15%)
Query: 76 LEAAARNDLEEVRQFLGSGVSPDLANEDGL------------------------------ 105
L AA +L++ L +GV + N++GL
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 106 ---TALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGAN 162
TALH + E+V++L+ GAN+NA + +TPL+ AA HL +V+ L+ +GAN
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 163 LLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRML---DDIRSR- 218
DG P + +Q + + + + G T+ + +P L + DD R+
Sbjct: 137 QNVATEDGFTPLAVA-LQQGHENVVAHLINYG-TKGKVR----LPALHIAARNDDTRTAA 190
Query: 219 --LQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWG 276
LQ + G T LH+AA A LLL AS++ Q+G PLH A+ G
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 277 QVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELKHKHDALLRAQSR 330
V +V LL+ GA + K+ + TPL C ++ E+ H A ++A+++
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDELTPLH-CAARNGHVRISEILLDHGAPIQAKTK 303
Score = 82.8 bits (203), Expect = 7e-16
Identities = 74/275 (26%), Positives = 115/275 (41%), Gaps = 36/275 (13%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA E VR+ + G + + ++ G T L+ ++ E+V+ LLE GAN N +
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 138 WTPLHAAATCGHLHLVELLIASGA---------NLLAVNTDGNMPYDLCDDEQTLDCLET 188
+TPL A GH ++V LI G ++ A N D L ++ D L
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 189 A-------------------MADRGIT-----QDSIEAARAVPELRMLDDIRSRLQAGAD 224
+ +RG + Q+ I + +R L GA
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 225 LHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELL 284
+ T LH AA NG + +LL+H A + AK ++G P+H AA + V LL
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Query: 285 VAHGADLNAKSLMDETPLDV---CGDEEVRAKLLE 316
+ + A+++ +L TPL V CG V LL+
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 98.6 bits (244), Expect = 1e-20
Identities = 83/255 (32%), Positives = 116/255 (45%), Gaps = 8/255 (3%)
Query: 58 AASQGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFR 117
A+ Q + + L P V AA L V L +G SPD+ N G TALH
Sbjct: 401 ASIQAITESGLTPIHV----AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQV 456
Query: 118 EMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLC 177
E+V+ LL GA ++A E TPLH A+ G +V+LL+ A+ A T+G P +
Sbjct: 457 EVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 516
Query: 178 DDEQTLD----CLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGA 233
E +D LE A T+ + LD + LQ A + +G
Sbjct: 517 AREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 576
Query: 234 TLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNA 293
T LHVAA + A LLLE AS A ++G+ PLH AA Q+ + L+ +GA+ N
Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636
Query: 294 KSLMDETPLDVCGDE 308
+ TPL + E
Sbjct: 637 VTKQGVTPLHLASQE 651
Score = 97.4 bits (241), Expect = 3e-20
Identities = 75/261 (28%), Positives = 123/261 (47%), Gaps = 11/261 (4%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA ++ L G + D +G+T LH MV+ LL+ G I+A +
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRG--- 194
TPLH AA GH +VELL+ GA LLA +G P + ++C++ + +
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 338
Query: 195 -ITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLE 253
+T D + A + L A+ +A +G T LH+A + LL++
Sbjct: 339 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK 398
Query: 254 HRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDV---CGDEEV 310
+ AS+ A + G P+H AA+ G + +V LL+ +GA + ++ ET L + G EV
Sbjct: 399 YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEV 458
Query: 311 RAKLLELKHKHDALLRAQSRQ 331
LL ++ AL+ A++R+
Sbjct: 459 VRCLL----RNGALVDARARE 475
Score = 94.7 bits (234), Expect = 2e-19
Identities = 76/261 (29%), Positives = 126/261 (48%), Gaps = 9/261 (3%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA + V++ LG G S D A + G TALH + E+V+ L++ GANINA
Sbjct: 50 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 109
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDE---QTLDCLETAMADRG 194
+TPL+ AA H+ +V+ L+ +GAN DG P + + Q + L
Sbjct: 110 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 169
Query: 195 ITQDSIEAARAVPE-----LRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAA 249
+ ++ A + L + +D + +Q+ ++ + G T LH+AA G A
Sbjct: 170 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 229
Query: 250 LLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEE 309
LLL A++ ++G PLH A+ G +V+LL+ G ++AK+ TPL C
Sbjct: 230 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLH-CAARS 288
Query: 310 VRAKLLELKHKHDALLRAQSR 330
+++EL + A L A+++
Sbjct: 289 GHDQVVELLLERGAPLLARTK 309
Score = 91.3 bits (225), Expect = 2e-18
Identities = 76/265 (28%), Positives = 130/265 (49%), Gaps = 17/265 (6%)
Query: 76 LEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDS 135
L AA +L++V ++L G+ + N++GL ALH + +VQ+LL G+++++
Sbjct: 15 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 74
Query: 136 ECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGI 195
+ T LH A+ G +V++L+ GAN+ A + +G P + E +D ++ + + G
Sbjct: 75 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK-YLLENGA 133
Query: 196 TQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGAT---LLHVAAANGFSEAAALLL 252
Q + P L + QA A L G LH+AA +++AALLL
Sbjct: 134 NQSTATEDGFTPLAVALQ--QGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLL 191
Query: 253 --EHRASLSAK------DQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDV 304
+H A + +K + G+ PLH AA++G V + LL+ GA ++ + TPL V
Sbjct: 192 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHV 251
Query: 305 C---GDEEVRAKLLELKHKHDALLR 326
G+ + LL+ + DA R
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTR 276
Score = 87.8 bits (216), Expect = 2e-17
Identities = 96/376 (25%), Positives = 144/376 (38%), Gaps = 37/376 (9%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA L+ + L + D A ++GLT LH D +++ LLE GA+ +A
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
+TPLH AA + + L+ GA V G P L E D + T + D+G
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMV-TLLLDKG--- 664
Query: 198 DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRAS 257
A++H G T LH+AA A +L +H A
Sbjct: 665 -------------------------ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 699
Query: 258 LSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVC---GDEEVRAKL 314
A + G+ PL A ++G V +V L+ GA++NAK+ TPL G + L
Sbjct: 700 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 759
Query: 315 LELKHKHDALLRAQSRQRSLLRR-RTSSAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQ 373
L+ K +A + ++ +R S KVV T T + K
Sbjct: 760 LQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMT 819
Query: 374 QPPPTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPVRHLYSKRLDRSVS 433
+ S E +D G LRP +E + + G + +R+ L+ S
Sbjct: 820 EVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRY----SLEGGRS 875
Query: 434 YQLSPLDSTTPHTLVH 449
L S HTL H
Sbjct: 876 DSLRSFSSDRSHTLSH 891
Score = 82.0 bits (201), Expect = 1e-15
Identities = 65/234 (27%), Positives = 111/234 (47%), Gaps = 9/234 (3%)
Query: 91 LGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHL 150
L +P+ +G T LH C + ++++ L++ GA+I A TP+H AA GHL
Sbjct: 364 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 423
Query: 151 HLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVP--- 207
++V LL+ +GA+ N G + ++ + + + G D+ P
Sbjct: 424 NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN-GALVDARAREEQTPLHI 482
Query: 208 --ELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDG 265
L + ++ LQ A A +G T LH++A G + A++LLE A+ S + G
Sbjct: 483 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 542
Query: 266 WEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCG---DEEVRAKLLE 316
+ PLH AA +G + + +LL+ A ++ TPL V +++V LLE
Sbjct: 543 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 596
Score = 75.1 bits (183), Expect = 1e-13
Identities = 81/314 (25%), Positives = 127/314 (40%), Gaps = 47/314 (14%)
Query: 56 KEAASQGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLT--------- 106
KE A+ Q F P L AA N ++ V+ L +G + A EDG T
Sbjct: 97 KEGANINAQSQNGFTP---LYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 153
Query: 107 --------------------ALHQCCIDDFREMVQQLLEAGAN--------INACDSECW 138
ALH D + LL+ N +N +
Sbjct: 154 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 213
Query: 139 TPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRG---- 194
TPLH AA G++++ LL+ GA + +G P + + ++ + DRG
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK-LLLDRGGQID 272
Query: 195 -ITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLE 253
T+D + + L+ GA L A +G + LH+AA E LL+
Sbjct: 273 AKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 332
Query: 254 HRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAK 313
H+A + D LH AA+ G + +LL+ A+ NA++L TPL + + R K
Sbjct: 333 HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKN-RIK 391
Query: 314 LLELKHKHDALLRA 327
++EL K+ A ++A
Sbjct: 392 VMELLVKYGASIQA 405
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 98.6 bits (244), Expect = 1e-20
Identities = 83/255 (32%), Positives = 116/255 (45%), Gaps = 8/255 (3%)
Query: 58 AASQGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFR 117
A+ Q + + L P V AA L V L +G SPD+ N G TALH
Sbjct: 422 ASIQAITESGLTPIHV----AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQV 477
Query: 118 EMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLC 177
E+V+ LL GA ++A E TPLH A+ G +V+LL+ A+ A T+G P +
Sbjct: 478 EVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 537
Query: 178 DDEQTLD----CLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGA 233
E +D LE A T+ + LD + LQ A + +G
Sbjct: 538 AREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 597
Query: 234 TLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNA 293
T LHVAA + A LLLE AS A ++G+ PLH AA Q+ + L+ +GA+ N
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 294 KSLMDETPLDVCGDE 308
+ TPL + E
Sbjct: 658 VTKQGVTPLHLASQE 672
Score = 97.4 bits (241), Expect = 3e-20
Identities = 75/261 (28%), Positives = 123/261 (47%), Gaps = 11/261 (4%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA ++ L G + D +G+T LH MV+ LL+ G I+A +
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRG--- 194
TPLH AA GH +VELL+ GA LLA +G P + ++C++ + +
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Query: 195 -ITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLE 253
+T D + A + L A+ +A +G T LH+A + LL++
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK 419
Query: 254 HRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDV---CGDEEV 310
+ AS+ A + G P+H AA+ G + +V LL+ +GA + ++ ET L + G EV
Sbjct: 420 YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEV 479
Query: 311 RAKLLELKHKHDALLRAQSRQ 331
LL ++ AL+ A++R+
Sbjct: 480 VRCLL----RNGALVDARARE 496
Score = 94.7 bits (234), Expect = 2e-19
Identities = 76/261 (29%), Positives = 126/261 (48%), Gaps = 9/261 (3%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA + V++ LG G S D A + G TALH + E+V+ L++ GANINA
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDE---QTLDCLETAMADRG 194
+TPL+ AA H+ +V+ L+ +GAN DG P + + Q + L
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190
Query: 195 ITQDSIEAARAVPE-----LRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAA 249
+ ++ A + L + +D + +Q+ ++ + G T LH+AA G A
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250
Query: 250 LLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEE 309
LLL A++ ++G PLH A+ G +V+LL+ G ++AK+ TPL C
Sbjct: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLH-CAARS 309
Query: 310 VRAKLLELKHKHDALLRAQSR 330
+++EL + A L A+++
Sbjct: 310 GHDQVVELLLERGAPLLARTK 330
Score = 93.6 bits (231), Expect = 4e-19
Identities = 82/301 (27%), Positives = 142/301 (47%), Gaps = 24/301 (7%)
Query: 40 AEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDL 99
A+K G+K G R++ + + L AA +L++V ++L G+ +
Sbjct: 7 AQKSDSGEKFNGSSQRRKRPKKS-------DSNASFLRAARAGNLDKVVEYLKGGIDINT 59
Query: 100 ANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIAS 159
N++GL ALH + +VQ+LL G+++++ + T LH A+ G +V++L+
Sbjct: 60 CNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119
Query: 160 GANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRL 219
GAN+ A + +G P + E +D ++ + + G Q + P L +
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVK-YLLENGANQSTATEDGFTPLAVALQ--QGHN 176
Query: 220 QAGADLHAPLDHGAT---LLHVAAANGFSEAAALLL--EHRASLSAK------DQDGWEP 268
QA A L G LH+AA +++AALLL +H A + +K + G+ P
Sbjct: 177 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236
Query: 269 LHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVC---GDEEVRAKLLELKHKHDALL 325
LH AA++G V + LL+ GA ++ + TPL V G+ + LL+ + DA
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 296
Query: 326 R 326
R
Sbjct: 297 R 297
Score = 87.8 bits (216), Expect = 2e-17
Identities = 96/376 (25%), Positives = 144/376 (38%), Gaps = 37/376 (9%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA L+ + L + D A ++GLT LH D +++ LLE GA+ +A
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
+TPLH AA + + L+ GA V G P L E D + T + D+G
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMV-TLLLDKG--- 685
Query: 198 DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRAS 257
A++H G T LH+AA A +L +H A
Sbjct: 686 -------------------------ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720
Query: 258 LSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVC---GDEEVRAKL 314
A + G+ PL A ++G V +V L+ GA++NAK+ TPL G + L
Sbjct: 721 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
Query: 315 LELKHKHDALLRAQSRQRSLLRR-RTSSAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQ 373
L+ K +A + ++ +R S KVV T T + K
Sbjct: 781 LQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMT 840
Query: 374 QPPPTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPVRHLYSKRLDRSVS 433
+ S E +D G LRP +E + + G + +R+ L+ S
Sbjct: 841 EVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRY----SLEGGRS 896
Query: 434 YQLSPLDSTTPHTLVH 449
L S HTL H
Sbjct: 897 DSLRSFSSDRSHTLSH 912
Score = 82.0 bits (201), Expect = 1e-15
Identities = 65/234 (27%), Positives = 111/234 (47%), Gaps = 9/234 (3%)
Query: 91 LGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHL 150
L +P+ +G T LH C + ++++ L++ GA+I A TP+H AA GHL
Sbjct: 385 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 444
Query: 151 HLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVP--- 207
++V LL+ +GA+ N G + ++ + + + G D+ P
Sbjct: 445 NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN-GALVDARAREEQTPLHI 503
Query: 208 --ELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDG 265
L + ++ LQ A A +G T LH++A G + A++LLE A+ S + G
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 563
Query: 266 WEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCG---DEEVRAKLLE 316
+ PLH AA +G + + +LL+ A ++ TPL V +++V LLE
Sbjct: 564 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 98.6 bits (244), Expect = 1e-20
Identities = 83/255 (32%), Positives = 116/255 (45%), Gaps = 8/255 (3%)
Query: 58 AASQGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFR 117
A+ Q + + L P V AA L V L +G SPD+ N G TALH
Sbjct: 422 ASIQAITESGLTPIHV----AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQV 477
Query: 118 EMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLC 177
E+V+ LL GA ++A E TPLH A+ G +V+LL+ A+ A T+G P +
Sbjct: 478 EVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 537
Query: 178 DDEQTLD----CLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGA 233
E +D LE A T+ + LD + LQ A + +G
Sbjct: 538 AREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 597
Query: 234 TLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNA 293
T LHVAA + A LLLE AS A ++G+ PLH AA Q+ + L+ +GA+ N
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 294 KSLMDETPLDVCGDE 308
+ TPL + E
Sbjct: 658 VTKQGVTPLHLASQE 672
Score = 97.4 bits (241), Expect = 3e-20
Identities = 75/261 (28%), Positives = 123/261 (47%), Gaps = 11/261 (4%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA ++ L G + D +G+T LH MV+ LL+ G I+A +
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRG--- 194
TPLH AA GH +VELL+ GA LLA +G P + ++C++ + +
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Query: 195 -ITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLE 253
+T D + A + L A+ +A +G T LH+A + LL++
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK 419
Query: 254 HRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDV---CGDEEV 310
+ AS+ A + G P+H AA+ G + +V LL+ +GA + ++ ET L + G EV
Sbjct: 420 YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEV 479
Query: 311 RAKLLELKHKHDALLRAQSRQ 331
LL ++ AL+ A++R+
Sbjct: 480 VRCLL----RNGALVDARARE 496
Score = 94.7 bits (234), Expect = 2e-19
Identities = 76/261 (29%), Positives = 126/261 (48%), Gaps = 9/261 (3%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA + V++ LG G S D A + G TALH + E+V+ L++ GANINA
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDE---QTLDCLETAMADRG 194
+TPL+ AA H+ +V+ L+ +GAN DG P + + Q + L
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190
Query: 195 ITQDSIEAARAVPE-----LRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAA 249
+ ++ A + L + +D + +Q+ ++ + G T LH+AA G A
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250
Query: 250 LLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEE 309
LLL A++ ++G PLH A+ G +V+LL+ G ++AK+ TPL C
Sbjct: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLH-CAARS 309
Query: 310 VRAKLLELKHKHDALLRAQSR 330
+++EL + A L A+++
Sbjct: 310 GHDQVVELLLERGAPLLARTK 330
Score = 93.6 bits (231), Expect = 4e-19
Identities = 82/301 (27%), Positives = 142/301 (47%), Gaps = 24/301 (7%)
Query: 40 AEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDL 99
A+K G+K G R++ + + L AA +L++V ++L G+ +
Sbjct: 7 AQKSDSGEKFNGSSQRRKRPKKS-------DSNASFLRAARAGNLDKVVEYLKGGIDINT 59
Query: 100 ANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIAS 159
N++GL ALH + +VQ+LL G+++++ + T LH A+ G +V++L+
Sbjct: 60 CNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119
Query: 160 GANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRL 219
GAN+ A + +G P + E +D ++ + + G Q + P L +
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVK-YLLENGANQSTATEDGFTPLAVALQ--QGHN 176
Query: 220 QAGADLHAPLDHGAT---LLHVAAANGFSEAAALLL--EHRASLSAK------DQDGWEP 268
QA A L G LH+AA +++AALLL +H A + +K + G+ P
Sbjct: 177 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236
Query: 269 LHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVC---GDEEVRAKLLELKHKHDALL 325
LH AA++G V + LL+ GA ++ + TPL V G+ + LL+ + DA
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 296
Query: 326 R 326
R
Sbjct: 297 R 297
Score = 87.8 bits (216), Expect = 2e-17
Identities = 96/376 (25%), Positives = 144/376 (38%), Gaps = 37/376 (9%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA L+ + L + D A ++GLT LH D +++ LLE GA+ +A
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
+TPLH AA + + L+ GA V G P L E D + T + D+G
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMV-TLLLDKG--- 685
Query: 198 DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRAS 257
A++H G T LH+AA A +L +H A
Sbjct: 686 -------------------------ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720
Query: 258 LSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVC---GDEEVRAKL 314
A + G+ PL A ++G V +V L+ GA++NAK+ TPL G + L
Sbjct: 721 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
Query: 315 LELKHKHDALLRAQSRQRSLLRR-RTSSAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQ 373
L+ K +A + ++ +R S KVV T T + K
Sbjct: 781 LQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMT 840
Query: 374 QPPPTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPVRHLYSKRLDRSVS 433
+ S E +D G LRP +E + + G + +R+ L+ S
Sbjct: 841 EVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRY----SLEGGRS 896
Query: 434 YQLSPLDSTTPHTLVH 449
L S HTL H
Sbjct: 897 DSLRSFSSDRSHTLSH 912
Score = 82.0 bits (201), Expect = 1e-15
Identities = 65/234 (27%), Positives = 111/234 (47%), Gaps = 9/234 (3%)
Query: 91 LGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHL 150
L +P+ +G T LH C + ++++ L++ GA+I A TP+H AA GHL
Sbjct: 385 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 444
Query: 151 HLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVP--- 207
++V LL+ +GA+ N G + ++ + + + G D+ P
Sbjct: 445 NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN-GALVDARAREEQTPLHI 503
Query: 208 --ELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDG 265
L + ++ LQ A A +G T LH++A G + A++LLE A+ S + G
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 563
Query: 266 WEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCG---DEEVRAKLLE 316
+ PLH AA +G + + +LL+ A ++ TPL V +++V LLE
Sbjct: 564 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 98.6 bits (244), Expect = 1e-20
Identities = 73/255 (28%), Positives = 117/255 (45%), Gaps = 5/255 (1%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
LL AA+ V L G + D + +G T L E+V+ LL+ G + N D
Sbjct: 785 LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADR- 193
WTPLH AA GH + E LI GA ++ DG +P+ L E DC++ + ++
Sbjct: 845 DAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKS 904
Query: 194 GITQ---DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAAL 250
I Q D A R D + GAD++ G L++ A A
Sbjct: 905 NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEY 964
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEV 310
LE+ A++ A D +G LH + + G + +V++L+A+ AD+NA + L +
Sbjct: 965 FLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAA-WQG 1023
Query: 311 RAKLLELKHKHDALL 325
K+++L +H A++
Sbjct: 1024 HVKVVQLLIEHGAVV 1038
Score = 81.6 bits (200), Expect = 2e-15
Identities = 61/191 (31%), Positives = 94/191 (49%), Gaps = 4/191 (2%)
Query: 118 EMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLC 177
+ ++ LL+ GA++N CDS T L AA G L +V LL++ GA+L + G+ P L
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585
Query: 178 DDE---QTLDCLETAMADRGIT-QDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGA 233
+ + ++CL A+ T QD A R+ + + + L AG +
Sbjct: 586 ARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSR 645
Query: 234 TLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNA 293
T L AA G + LL+H A ++ D +G L AAAY G +VE L+ HGA++N
Sbjct: 646 TALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNH 705
Query: 294 KSLMDETPLDV 304
+ + T L V
Sbjct: 706 EDVDGRTALSV 716
Score = 80.9 bits (198), Expect = 3e-15
Identities = 64/238 (26%), Positives = 103/238 (43%), Gaps = 9/238 (3%)
Query: 74 VLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINAC 133
+L AA L+ V + G ++ + G T L ++V L+ GANIN
Sbjct: 548 LLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHT 607
Query: 134 DSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLC----DDEQTLDCLETA 189
D + WT L +AA GH +V L+ +G + + D ++ L+ L+
Sbjct: 608 DQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHG 667
Query: 190 MADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVA-----AANGF 244
+ A A + + + L GA+++ G T L VA A+ G
Sbjct: 668 AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGH 727
Query: 245 SEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPL 302
+ +LL++ A + D+DG PL AAY G V +V+LL+ GAD++ TPL
Sbjct: 728 ASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPL 785
Score = 79.3 bits (194), Expect = 8e-15
Identities = 73/243 (30%), Positives = 106/243 (43%), Gaps = 9/243 (3%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AA E V L +GV D A+ D TAL ++V LL+ GA +N D
Sbjct: 615 LRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKAD 674
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYD---LC-DDEQTLDCLETAM 190
+E T L AAA GH +VE L+ GA + + DG LC + + + +
Sbjct: 675 NEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLL 734
Query: 191 ADRGITQDSIEAARAVPEL-----RMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFS 245
DRG D + P L +D + L+ GAD+ ++G T L AA+ G +
Sbjct: 735 IDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHA 794
Query: 246 EAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVC 305
LL A++ + D +G L A+ G V +V L+ G D N + TPL +
Sbjct: 795 SVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMA 854
Query: 306 GDE 308
E
Sbjct: 855 AFE 857
Score = 67.4 bits (163), Expect = 3e-11
Identities = 61/231 (26%), Positives = 100/231 (43%), Gaps = 35/231 (15%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA + V G + + DG L+ +++ M + LE GAN+ A D+E
Sbjct: 920 AALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEG 979
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
T LH + GH+ +V++LIA A++ A D + L++A Q
Sbjct: 980 RTALHVSCWQGHMEMVQVLIAYHADVNAA------------DNEKRSALQSAA-----WQ 1022
Query: 198 DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRAS 257
++ + + ++ GA + + GAT L +AA G + +LLEH A
Sbjct: 1023 GHVKVVQLL------------IEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGAD 1070
Query: 258 LSAKDQDGWEPLHAAAYWGQVPLVELLVAHGA-DLNAKS-----LMDETPL 302
+ DQ G + AA G +++LL +GA LN S M++ PL
Sbjct: 1071 PNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPL 1121
Score = 41.6 bits (96), Expect = 0.002
Identities = 27/84 (32%), Positives = 46/84 (54%), Gaps = 2/84 (2%)
Query: 219 LQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQV 278
++AGA +++ D + ++ A ++ LL++ AS++ D +G L AAY G +
Sbjct: 501 VKAGAHVNSEDDRTSCIVRQALER--EDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSL 558
Query: 279 PLVELLVAHGADLNAKSLMDETPL 302
+V LLV+ GADL + TPL
Sbjct: 559 DVVNLLVSRGADLEIEDAHGHTPL 582
Score = 39.3 bits (90), Expect = 0.009
Identities = 29/90 (32%), Positives = 43/90 (47%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AA + ++ V+ + G D G TAL + ++VQ LLE GA+ N D
Sbjct: 1016 LQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHAD 1075
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLL 164
T + AA GH +++LL GA+ L
Sbjct: 1076 QFGRTAMRVAAKNGHSQIIKLLEKYGASSL 1105
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 96.7 bits (239), Expect = 5e-20
Identities = 76/253 (30%), Positives = 109/253 (43%), Gaps = 14/253 (5%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA D R L G D +G T LH ++F + + L+ A+ N ++E
Sbjct: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG 494
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
TPLH AA GH+ LV+LL + GA L A + P L + + ++ + G
Sbjct: 495 KTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS-GAVP 553
Query: 198 DSIEAARAVPELRMLDDIRSR---------LQAGADLHAPLDHGATLLHVAAANGFSEAA 248
D+++ + P L +R L+ GA L P G T LH+AA G E
Sbjct: 554 DALDQSGYGP----LHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEII 609
Query: 249 ALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDE 308
LL E A++ A W PLH AA G+ +V L+ GAD NA TPL +
Sbjct: 610 HLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669
Query: 309 EVRAKLLELKHKH 321
++ L H
Sbjct: 670 STFLSVINLLEHH 682
Score = 92.0 bits (227), Expect = 1e-18
Identities = 68/227 (29%), Positives = 100/227 (44%), Gaps = 29/227 (12%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
A R + ++ L SG PD ++ G LH + + LL GA++ +
Sbjct: 534 AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQG 593
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
WTPLH AA GHL ++ LL S AN+ A+ P L
Sbjct: 594 WTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHL--------------------- 632
Query: 198 DSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRAS 257
AAR E + + LQ GAD +A G T LH+A + LLEH A+
Sbjct: 633 ----AARHGEEAV----VSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHAN 684
Query: 258 LSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDV 304
+ A+++ GW P H AA G ++++LV GA L+ + + TPL +
Sbjct: 685 VHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731
Score = 83.6 bits (205), Expect = 4e-16
Identities = 72/250 (28%), Positives = 110/250 (44%), Gaps = 9/250 (3%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
LL AA + L G + +EDG LH + + LL+ GA ++A +
Sbjct: 399 LLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQE 458
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRG 194
E WTPLH AA ++ LL++ A+ +G P + + L + +G
Sbjct: 459 REGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVS-LVKLLTSQG 517
Query: 195 ITQDSIEAARAVP-----ELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAA 249
D+ + P E + I+ L++GA A G LH AAA G
Sbjct: 518 AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICK 577
Query: 250 LLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVC---G 306
+LL + ASL GW PLH AAY G + ++ LL A++ A ++ TPL + G
Sbjct: 578 MLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHG 637
Query: 307 DEEVRAKLLE 316
+E V + LL+
Sbjct: 638 EEAVVSALLQ 647
Score = 75.1 bits (183), Expect = 1e-13
Identities = 65/218 (29%), Positives = 94/218 (43%), Gaps = 32/218 (14%)
Query: 102 EDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGA 161
E+ +T LH E V+ LL +++ + +TPL AA L LL+A GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 162 NLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQA 221
+ V+ DG P D G R L
Sbjct: 420 DANRVDEDGWAPLHFAAQN----------GDDGTA-------------------RLLLDH 450
Query: 222 GADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLV 281
GA + A G T LH+AA N F A LL+ +A + + +G PLH AAY+G V LV
Sbjct: 451 GACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV 510
Query: 282 ELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELKH 319
+LL + GA+L+A+ TPL + + R K+ ++H
Sbjct: 511 KLLTSQGAELDAQQRNLRTPLHLAVE---RGKVRAIQH 545
Score = 47.8 bits (112), Expect = 3e-05
Identities = 36/105 (34%), Positives = 46/105 (43%), Gaps = 7/105 (6%)
Query: 230 DHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGA 289
++ T LH A G E LLL H + + G+ PL AA Q L LL+AHGA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 290 DLNAKSLMDETPLDVC---GDEEVRAKLLELKHKHDALLRAQSRQ 331
D N PL GD+ LL+ H A + AQ R+
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLD----HGACVDAQERE 460
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 92.4 bits (228), Expect = 9e-19
Identities = 75/234 (32%), Positives = 113/234 (48%), Gaps = 13/234 (5%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA+ + V+ L GV D N G TALH C + +V +L++ GAN+N ++
Sbjct: 188 AASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNG 247
Query: 138 WTPLHAAATCGHLHL-VELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRG-- 194
+TPLH AA H L +ELL+ +GA++ + DG P + +T + + G
Sbjct: 248 FTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEI 307
Query: 195 --ITQDSIE----AARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAA 248
+ +D AAR EL +++ +R+ +GAD H LH+AA N S+
Sbjct: 308 DCVDKDGNTPLHVAARYGHEL-LINTLRT---SGADTAKCGIHSMFPLHLAALNAHSDCC 363
Query: 249 ALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPL 302
LL + D+ G LHAAA G V ++LL + GAD + K TPL
Sbjct: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPL 417
Score = 84.3 bits (207), Expect = 2e-16
Identities = 65/208 (31%), Positives = 98/208 (47%), Gaps = 30/208 (14%)
Query: 96 SPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVEL 155
S ++++ G TALH ++ EMV LL GANINA D + LH AA GHL +V L
Sbjct: 107 SVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVAL 166
Query: 156 LIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDI 215
LI GA + + G P A A G ++ +
Sbjct: 167 LINHGAEVTCKDKKGYTPLH-------------AAASNG----------------QINVV 197
Query: 216 RSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLH-AAAY 274
+ L G ++ +G T LH+A NG L+++ A+++ + +G+ PLH AAA
Sbjct: 198 KHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAS 257
Query: 275 WGQVPLVELLVAHGADLNAKSLMDETPL 302
+ELLV +GAD+N +S ++PL
Sbjct: 258 THGALCLELLVNNGADVNIQSKDGKSPL 285
Score = 78.2 bits (191), Expect = 2e-14
Identities = 65/221 (29%), Positives = 97/221 (43%), Gaps = 7/221 (3%)
Query: 88 RQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATC 147
R+ L SG D ++ G T LH E ++ L +GA+ + D TPLH AA
Sbjct: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAAN 423
Query: 148 GHLHLVELLIASGANLLAVNTDGN--MPYDLCDDEQTLDCLETAMADRGITQDSIEAARA 205
H H +E L+ +GAN+ + G + Y D +D +T + + + +E AR
Sbjct: 424 CHFHCIETLVTTGANVNETDDWGRTALHYAAASD---MDRNKTILGNAHDNSEELERARE 480
Query: 206 VPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDG 265
+ E + LQ A+ G +H AAA G + LLLE S + G
Sbjct: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
Query: 266 W--EPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDV 304
PLH AAY G +E+L+ DL+ + T LD+
Sbjct: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDL 581
Score = 77.8 bits (190), Expect = 2e-14
Identities = 61/222 (27%), Positives = 109/222 (49%), Gaps = 15/222 (6%)
Query: 106 TALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLA 165
T LH E+++ L+ +GA +NA D+ TPLH A V++LI A++ A
Sbjct: 18 TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77
Query: 166 VNTDGNMPYDLCDDEQTLDCLETA--------MADRGITQDSIEAARAVPELRMLDDIRS 217
+ + P + + + C E ++DRG + ++ A + M++ +
Sbjct: 78 RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRG-GRTALHHAALNGHVEMVNLL-- 134
Query: 218 RLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQ 277
L GA+++A LH AA G + ALL+ H A ++ KD+ G+ PLHAAA GQ
Sbjct: 135 -LAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQ 193
Query: 278 VPLVELLVAHGADLNAKSLMDETPLDVC---GDEEVRAKLLE 316
+ +V+ L+ G +++ ++ T L + G + V +L++
Sbjct: 194 INVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELID 235
Score = 74.3 bits (181), Expect = 3e-13
Identities = 62/180 (34%), Positives = 87/180 (48%), Gaps = 29/180 (16%)
Query: 123 LLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQT 182
L+ ++N DSE TPLH AA G ++ELLI SGA VN NM
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGAR---VNAKDNM---------W 49
Query: 183 LDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAAN 242
L L A+A R S EA + + ++ AD++A + T LHVAAAN
Sbjct: 50 LTPLHRAVASR-----SEEAVQVL------------IKHSADVNARDKNWQTPLHVAAAN 92
Query: 243 GFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPL 302
+ A +++ +S++ D+ G LH AA G V +V LL+A GA++NA D L
Sbjct: 93 KAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRAL 152
Score = 73.6 bits (179), Expect = 4e-13
Identities = 60/226 (26%), Positives = 101/226 (44%), Gaps = 15/226 (6%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AA +E V L G + + ++ ALH ++V L+ GA + D
Sbjct: 119 LHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDL-CDDEQTLDCLETAMADR 193
+ +TPLHAAA+ G +++V+ L+ G + +N GN + C + Q D + + D
Sbjct: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQ--DAVVNELIDY 236
Query: 194 GITQDSIE---------AARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGF 244
G + AA + L+ + + GAD++ G + LH+ A +G
Sbjct: 237 GANVNQPNNNGFTPLHFAAASTHGALCLELL---VNNGADVNIQSKDGKSPLHMTAVHGR 293
Query: 245 SEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGAD 290
+ L+++ + D+DG PLH AA +G L+ L GAD
Sbjct: 294 FTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD 339
Score = 66.6 bits (161), Expect = 5e-11
Identities = 65/257 (25%), Positives = 103/257 (40%), Gaps = 4/257 (1%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA D E + + SG + + LT LH+ E VQ L++ A++NA D
Sbjct: 23 AAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNW 82
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMAD----R 193
TPLH AA + E++I +++ + G ++ + +A
Sbjct: 83 QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANIN 142
Query: 194 GITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLE 253
+ A + LD + + GA++ G T LH AA+NG LL
Sbjct: 143 AFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLN 202
Query: 254 HRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAK 313
+ + G LH A Y GQ +V L+ +GA++N + TPL A
Sbjct: 203 LGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGAL 262
Query: 314 LLELKHKHDALLRAQSR 330
LEL + A + QS+
Sbjct: 263 CLELLVNNGADVNIQSK 279
Score = 61.2 bits (147), Expect = 2e-09
Identities = 80/271 (29%), Positives = 104/271 (38%), Gaps = 30/271 (11%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L+ A A ++ V L + D + G TALH+ + E VQ LLE +I D
Sbjct: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708
Query: 135 SECWTPLHAAATCGH-LHLVELL--IASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMA 191
S TPLH AA GH L ELL S + + G P +C+E +
Sbjct: 709 SRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
Query: 192 DR---------------GITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLL 236
+ I D A +L I S + + D D G T L
Sbjct: 769 QKCFRKFIGNPFTPLHCAIINDHGNCASL-----LLGAIDSSIVSCRD-----DKGRTPL 818
Query: 237 HVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLV-AHGADLNAKS 295
AA E LLL H A ++A D G L AA GQ V++LV + ADL K
Sbjct: 819 RAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKD 878
Query: 296 LMDETPLDV-CGDEEVRAKLLELKHKHDALL 325
TPL + C + LL L D L
Sbjct: 879 KDLNTPLHLACSKGHEKCALLILDKIQDESL 909
Score = 55.8 bits (133), Expect = 9e-08
Identities = 58/226 (25%), Positives = 98/226 (43%), Gaps = 18/226 (7%)
Query: 91 LGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLE-AGANINACDSECW-TPLHAAATCG 148
L + +P + +++G ++H R+ ++ LLE + DS +PLH AA G
Sbjct: 494 LQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNG 553
Query: 149 HLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGIT---QDSIEAARA 205
H +E+L+ S +L + G DL + +C+E A+ + G + +D++
Sbjct: 554 HHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVE-ALINPGASIFVKDNVTKRTP 612
Query: 206 VPE---------LRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRA 256
+ LR+L +I +A A G T L +A A G +A +LLLE A
Sbjct: 613 LHASVINGHTLCLRLLLEIADNPEAVDVKDAK---GQTPLMLAVAYGHIDAVSLLLEKEA 669
Query: 257 SLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPL 302
++ D G LH G V++L+ + K TPL
Sbjct: 670 NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPL 715
Score = 55.8 bits (133), Expect = 9e-08
Identities = 70/248 (28%), Positives = 97/248 (39%), Gaps = 33/248 (13%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA + + L S V D+ +E G TAL E V+ L+ GA+I D+
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
Query: 138 W-TPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGIT 196
TPLHA+ GH + LL+ ++ D+ + +D + +G T
Sbjct: 609 KRTPLHASVINGHTLCLRLLL-----------------EIADNPEAVDVKDA----KGQT 647
Query: 197 QDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRA 256
+ A +D + L+ A++ G T LH G E +LLE
Sbjct: 648 PLMLAVAYG-----HIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEV 702
Query: 257 SLSAKDQDGWEPLHAAAYWGQVP-LVELL--VAHGADLNAKSLMDETPLD-VC--GDEEV 310
S+ KD G PLH AA G L ELL D K TPL C G+E
Sbjct: 703 SILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENC 762
Query: 311 RAKLLELK 318
LLE K
Sbjct: 763 IEVLLEQK 770
Score = 43.9 bits (102), Expect = 4e-04
Identities = 29/87 (33%), Positives = 44/87 (50%), Gaps = 3/87 (3%)
Query: 250 LLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLD--VCGD 307
+L+ ++ D + PLH AA+ G ++ELL+ GA +NAK M TPL V
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 308 EEVRAKLLELKHKHDALLRAQSRQRSL 334
E ++L +KH D R ++ Q L
Sbjct: 61 SEEAVQVL-IKHSADVNARDKNWQTPL 86
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 92.0 bits (227), Expect = 1e-18
Identities = 114/456 (25%), Positives = 179/456 (39%), Gaps = 71/456 (15%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
A + LE VR L +G + ++ TAL + C+D E+ + LL++GA +N
Sbjct: 408 ACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 467
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDE----------------- 180
+PL AA GH+ L LLI GA+L VN +G P E
Sbjct: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
Query: 181 -QTLDCLETAM-----------ADRGITQDS-IEAARAVPELRM-----LDDIRSRLQAG 222
QT + ETA+ AD I + IE + P + L+ ++ L AG
Sbjct: 528 AQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAG 587
Query: 223 ADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVE 282
A++HA G T L A NG ++ A +LL+ A L + + G PL AA G V V+
Sbjct: 588 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQ 647
Query: 283 LLVAHGADLNAKSL-MDETPLDV-CGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTS 340
L++ GA++N + D T L + C + L L H D R + L+ +
Sbjct: 648 FLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE---A 704
Query: 341 SAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQQPPPTSPEPPEDNDDRQTGAELRPPPP 400
+ G VV Y + + P T PP + +R ++ P
Sbjct: 705 AKGGHTSVV----------CYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPM 754
Query: 401 EEDNPEVVRPHNGRVGGSPVRHLYSKRLDRSVSYQLSPLDSTTPHTLVHDKAHHTLADLK 460
E +P P+R +++VS + S + +T H++
Sbjct: 755 VVPPQEPDKPPANVATTLPIR-------NKAVSGRASAMSNTPTHSIA------------ 795
Query: 461 RQRAAAKLQRPPPEGPESPETAEPGLPGDTVTPQPD 496
+ ++ Q P P SP P P + Q +
Sbjct: 796 --ASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTE 829
Score = 89.0 bits (219), Expect = 1e-17
Identities = 71/232 (30%), Positives = 115/232 (49%), Gaps = 17/232 (7%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L+ AA ++ V+ L + + G TAL C + ++V+ LLE+GA+I +
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDC------LET 188
TPL A + GH+ + LL+ +GA +NT N + + TL C +
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGA---GINTHSN---EFKESALTLACYKGHLEMVR 418
Query: 189 AMADRGITQD--SIEAARAVPELRM---LDDIRSRLQAGADLHAPLDHGATLLHVAAANG 243
+ + G Q+ + E A+ E M ++ R L +GA ++ P D + L +AA G
Sbjct: 419 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 478
Query: 244 FSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKS 295
E AALL+E ASL + +G+ PL AA G +V LL+ GA++NA++
Sbjct: 479 HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT 530
Score = 70.1 bits (170), Expect = 5e-12
Identities = 61/206 (29%), Positives = 105/206 (50%), Gaps = 10/206 (4%)
Query: 106 TALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLA 165
TAL C E+VQ LLE GA+I D + +TPL AAT GH+ +VE+L+ +GA++ A
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
Query: 166 VN-TDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVP-----ELRMLDDIRSRL 219
+ + P L + +E +A RG ++ + P ++ I+ L
Sbjct: 894 QSERTKDTPLSLACSGGRQEVVELLLA-RGANKEHRNVSDYTPLSLAASGGYVNIIKILL 952
Query: 220 QAGADLHAPLDH--GATLLHVAAANGFSEAAALLLEHRASLSAK-DQDGWEPLHAAAYWG 276
AGA++++ G + L +AA NG + A LLL+ + ++A+ + + L A + G
Sbjct: 953 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1012
Query: 277 QVPLVELLVAHGADLNAKSLMDETPL 302
+ +V LL+ A++ ++ TPL
Sbjct: 1013 RTEVVSLLLDRKANVEHRAKTGLTPL 1038
Score = 63.2 bits (152), Expect = 6e-10
Identities = 62/241 (25%), Positives = 106/241 (43%), Gaps = 10/241 (4%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
A A E V+ L G S + ++ G T L +V+ LL+ GA+I A
Sbjct: 839 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 898
Query: 138 W-TPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGIT 196
TPL A + G +VELL+A GAN N P L ++ ++ +
Sbjct: 899 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 958
Query: 197 QDSIEAARAVPELRM------LDDIRSRLQAGADLHAPLD-HGATLLHVAAANGFSEAAA 249
+ + L + ++ L G+D++A ++ + T L +A G +E +
Sbjct: 959 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS 1018
Query: 250 LLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMD--ETPLDVCGD 307
LLL+ +A++ + + G PL AA G + +L+ GAD+NA + +T L + D
Sbjct: 1019 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1078
Query: 308 E 308
+
Sbjct: 1079 K 1079
Score = 62.4 bits (150), Expect = 1e-09
Identities = 65/232 (28%), Positives = 102/232 (43%), Gaps = 19/232 (8%)
Query: 85 EEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECW--TPLH 142
E V L G + + N T L + +++ LL AGA IN+ +PL
Sbjct: 913 EVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLM 972
Query: 143 AAATCGHLHLVELLIASGANLLA-VNTDGNMPYDLCDDEQTLDCLETAM---------AD 192
AA GH V+LL+ G+++ A + T+ N L + + + + A
Sbjct: 973 LAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAK 1032
Query: 193 RGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGA--TLLHVAAANGFSEAAAL 250
G+T A+ E+ R L GAD++AP + T L +AA G + L
Sbjct: 1033 TGLTPLMEAASGGYAEVG-----RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1087
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPL 302
L+ A + +++ G PL AA G + +V+LLV GAD++A TPL
Sbjct: 1088 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1139
Score = 55.1 bits (131), Expect = 2e-07
Identities = 56/189 (29%), Positives = 78/189 (41%), Gaps = 32/189 (16%)
Query: 72 SVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANIN 131
S L+EAA LE V+ L +G + G TAL C + ++ LL+AGA++
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Query: 132 ACDSECWTPLHAAATCGHLHLVELLIASGANL--LAVNTDGNMPYDLCDDEQTLDCLETA 189
TPL AA GH+ V+ LI+ GAN+ N D + L A
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTV-------------LSLA 671
Query: 190 MADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAA 249
A + AV EL L GAD L G+T+L AA G +
Sbjct: 672 CAGGHL---------AVVEL--------LLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
Query: 250 LLLEHRASL 258
LL++ +L
Sbjct: 715 YLLDYPNNL 723
Score = 47.0 bits (110), Expect = 4e-05
Identities = 39/143 (27%), Positives = 61/143 (42%), Gaps = 15/143 (10%)
Query: 30 RAQQVKMWAQAEKEAQGKKGPGERPRKEAASQGLLK----------QVLFPP-----SVV 74
R + V + + + + G P EAAS G + V PP
Sbjct: 1013 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1072
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AA + + +G G D+ N+ G T L ++VQ L++AGA+++A D
Sbjct: 1073 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1132
Query: 135 SECWTPLHAAATCGHLHLVELLI 157
+ TPL AA GH+ +V L+
Sbjct: 1133 NRKITPLMAAFRKGHVKVVRYLV 1155
Score = 39.3 bits (90), Expect = 0.009
Identities = 65/280 (23%), Positives = 106/280 (37%), Gaps = 49/280 (17%)
Query: 52 ERPRKEAASQGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDG------- 104
E P E AS+ LL + ++ + LE + + G G L+ DG
Sbjct: 143 ENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIG---KLSTADGKAFADPE 199
Query: 105 ----LTALHQCCIDDFREMVQQL-LEAGANINACDSECWTPLHAAATCGHLHLVELLIAS 159
LT+ C +D+ + ++ E+ AN D+ L A + G ++ V L+
Sbjct: 200 VLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRS---LAEACSEGDVNAVRKLLIE 256
Query: 160 GANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRL 219
G ++ +G ++L CL + + Q + V + + DI
Sbjct: 257 GRSVNEHTEEG----------ESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI---- 302
Query: 220 QAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVP 279
T L AA G + LLL H+A ++A+ G L A G V
Sbjct: 303 --------------TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVD 348
Query: 280 LVELLVAHGADLNAKSLMDETPL---DVCGDEEVRAKLLE 316
+V++L+ GA + + TPL G EV LLE
Sbjct: 349 VVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLE 388
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 91.3 bits (225), Expect = 2e-18
Identities = 83/284 (29%), Positives = 119/284 (41%), Gaps = 38/284 (13%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA+ + V+ L GV + N G T LH C + +V +L++ GA +N + +
Sbjct: 213 AASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKG 272
Query: 138 WTPLHAAATCGHLHL-VELLIASGANLLAVNTDGNMPYDL-------------------- 176
+TPLH AA H L +ELL+ +GA++ + DG P +
Sbjct: 273 FTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVI 332
Query: 177 -CDDEQTLDCLETA-------MADRGITQDSIEAARAVPELRML---------DDIRSRL 219
C+D+ L A + + IT + A R + + L D R L
Sbjct: 333 DCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLL 392
Query: 220 QAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVP 279
+G D+ P D G T LH AAA G E LLL A + KD+ G PLH AA
Sbjct: 393 SSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQ 452
Query: 280 LVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELKHKHDA 323
+ LV GA +N TPL + K LE ++DA
Sbjct: 453 CLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDA 496
Score = 88.2 bits (217), Expect = 2e-17
Identities = 63/234 (26%), Positives = 105/234 (44%), Gaps = 4/234 (1%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L++A D +EVR + + + + T LH E+++ L+ +GA +NA D
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD 71
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRG 194
S+ TPLH A V++L+ A++ A + + P + + + C E +
Sbjct: 72 SKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLS 131
Query: 195 ITQDSIEAARAVPELRMLDD----IRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAAL 250
S A R ++ L GA+++A +H AA G E L
Sbjct: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDV 304
L+ H A ++ KD+ + PLHAAA G + +V+ L+ G D+N + TPL V
Sbjct: 192 LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
Score = 77.0 bits (188), Expect = 4e-14
Identities = 62/203 (30%), Positives = 98/203 (48%), Gaps = 10/203 (4%)
Query: 107 ALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAV 166
+L Q + + V+ L+ ++N D+E TPLHAAA G ++ELLI SGA + A
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 167 NTDGNMPYD---LCDDEQTLDCLETAMADRGIT----QDSIEAARAVPELRMLDDIRSRL 219
++ P E+ + L AD Q + A A ++ + + L
Sbjct: 71 DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
Query: 220 QAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVP 279
++++ G T LH AA +G E LLL A+++A D+ +H AAY G +
Sbjct: 131 ---SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIE 187
Query: 280 LVELLVAHGADLNAKSLMDETPL 302
+V+LLV+HGA++ K TPL
Sbjct: 188 VVKLLVSHGAEVTCKDKKSYTPL 210
Score = 71.6 bits (174), Expect = 2e-12
Identities = 69/246 (28%), Positives = 111/246 (45%), Gaps = 17/246 (6%)
Query: 87 VRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAAT 146
V L G + D ++ G TALH+ + E V LL+ GA DS TP+H +A
Sbjct: 669 VYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAA 728
Query: 147 CGHLHLVELLIASGANLLA--VNTDGN----MPYDLCDDEQTLDCLETAMADRGITQDSI 200
CGH+ ++ L+ S A++ A D + + + + +T C+E + ++ + Q +
Sbjct: 729 CGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHET--CVELLL-EQEVFQKTE 785
Query: 201 EAARAVPELRMLDDIRSRLQAGAD------LHAPLDHGATLLHVAAANGFSEAAALLLEH 254
A + +++D + D ++A G T LH AA E LLL H
Sbjct: 786 GNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSH 845
Query: 255 RASLSAKDQDGWEPLHAAAYWGQVPLVELLVAH-GADLNAKSLMDETPLDV-CGDEEVRA 312
A +++ D G PL AA GQ VE+LV+ A+L + T L + C +
Sbjct: 846 NAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETS 905
Query: 313 KLLELK 318
LL L+
Sbjct: 906 ALLILE 911
Score = 71.2 bits (173), Expect = 2e-12
Identities = 65/233 (27%), Positives = 105/233 (45%), Gaps = 18/233 (7%)
Query: 88 RQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATC 147
R+ L SG D ++ G T LH E + LL GA+ N D +PLH AA
Sbjct: 389 RKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAAN 448
Query: 148 GHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLD-CLETAM---ADRGITQ----DS 199
+ + L+ SGA++ ++ G P T CLE + A+ GI ++
Sbjct: 449 CNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNA 508
Query: 200 IEAARAVPELRMLDDIRSRLQ-------AGADLHAPLDHGATL--LHVAAANGFSEAAAL 250
+ + A L I S +G D+ + D+ AT+ LH+AA +G +A +
Sbjct: 509 VHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEV 568
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKS-LMDETPL 302
L++ L ++ G PL AA+ G V V++L+ GA + K ++ TP+
Sbjct: 569 LVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPI 621
Score = 70.1 bits (170), Expect = 5e-12
Identities = 67/249 (26%), Positives = 103/249 (41%), Gaps = 31/249 (12%)
Query: 76 LEAAARNDLEEVRQFLGSGVSP----DLANEDGLTALHQCCIDDFREMVQQLLEAGANIN 131
+ AAA N E + L P D+ + +G T L ++ + V LL GAN++
Sbjct: 621 IHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVD 680
Query: 132 ACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDL---CDDEQTLDCL-- 186
A D T LH A GH V+ L+ GA L ++ G P L C L L
Sbjct: 681 AKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQ 740
Query: 187 -ETAMADRGITQDS----------IEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATL 235
+M T D+ EL + ++ + + A +
Sbjct: 741 SAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNA---------FSP 791
Query: 236 LHVAAANGFSEAAALLLEHRAS--LSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNA 293
LH A N AA +L++ + ++A D G PLHAAA+ V ++LL++H A +N+
Sbjct: 792 LHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS 851
Query: 294 KSLMDETPL 302
+TPL
Sbjct: 852 VDSTGKTPL 860
Score = 63.9 bits (154), Expect = 3e-10
Identities = 52/224 (23%), Positives = 99/224 (44%), Gaps = 10/224 (4%)
Query: 79 AARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECW 138
A+ L+ + + G+ + D N ++ LH + ++ L+++ +++ +S
Sbjct: 525 ASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGR 584
Query: 139 TPLHAAATCGHLHLVELLIASGANLLAVN-TDGNMPYDLCDDEQTLDCLETAMADRGITQ 197
TPL AA GH+ V++LI GA++L + P +CL + + Q
Sbjct: 585 TPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGN-AEPQ 643
Query: 198 DSIEAARAVPELRML--------DDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAA 249
++++ + ++ D + S L GA++ A G T LH A G E
Sbjct: 644 NAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVD 703
Query: 250 LLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNA 293
LL+H A +D G P+H +A G + ++ L+ A ++A
Sbjct: 704 ALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDA 747
Score = 62.0 bits (149), Expect = 1e-09
Identities = 59/220 (26%), Positives = 98/220 (44%), Gaps = 33/220 (15%)
Query: 103 DGLTALHQCCIDDFREMVQQLLEA-GANI-NACDSECWTPLHAAATCGHLHLVELLIASG 160
+ + LH I+D + L++ GA+I NA DS+ TPLHAAA H+ ++LL++
Sbjct: 787 NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHN 846
Query: 161 ANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQ 220
A + +V++ G P + + + +E ++ A EL + D+ ++
Sbjct: 847 AQVNSVDSTGKTPLMMAAENGQTNTVEMLVSS------------ASAELTLQDNSKN--- 891
Query: 221 AGADLHAPLDHGATLLHVAAANGFSEAAALLLEH---RASLSAKDQDGWEPLHAAAYWGQ 277
T LH+A + G +A L+LE R ++A + PLH AA G
Sbjct: 892 -------------TALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGL 938
Query: 278 VPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLEL 317
+V+ L+ GA + A TP C + A L L
Sbjct: 939 TMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLAL 978
Score = 58.2 bits (139), Expect = 2e-08
Identities = 55/201 (27%), Positives = 81/201 (40%), Gaps = 28/201 (13%)
Query: 76 LEAAARNDLEEVRQFLGSGVSPDLAN---EDGLTALHQCCIDDFREMVQQLLEAGANINA 132
L A ND E + L + + N G T LH D E +Q LL A +N+
Sbjct: 792 LHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS 851
Query: 133 CDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMAD 192
DS TPL AA G + VE+L++S + L + D L A
Sbjct: 852 VDSTGKTPLMMAAENGQTNTVEMLVSSASAELTL-----------QDNSKNTALHLA-CS 899
Query: 193 RGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLL 252
+G ++ + + +++ + LQ T LHVAA NG + LL
Sbjct: 900 KGHETSALLILEKITDRNLINATNAALQ-------------TPLHVAARNGLTMVVQELL 946
Query: 253 EHRASLSAKDQDGWEPLHAAA 273
AS+ A D++G+ P A A
Sbjct: 947 GKGASVLAVDENGYTPALACA 967
Score = 57.8 bits (138), Expect = 2e-08
Identities = 58/235 (24%), Positives = 88/235 (37%), Gaps = 17/235 (7%)
Query: 87 VRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAAT 146
+ + SG G+ LH + F + ++LL +G +I+ D T LHAAA
Sbjct: 355 INTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAA 414
Query: 147 CGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAV 206
G+L + LL+ +GA+ + G P CL + D E
Sbjct: 415 GGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTP 474
Query: 207 PELRMLDDIRSR-----LQAGADLHAPLDHGATLLHVAAANGFSEAAAL---------LL 252
D + L+ A+ G +H +AA G L L+
Sbjct: 475 LHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLM 534
Query: 253 EHRASLSAKDQDGW---EPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDV 304
E + D D PLH AAY G +E+LV DL+ ++ TPLD+
Sbjct: 535 ETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDL 589
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 90.9 bits (224), Expect = 3e-18
Identities = 101/370 (27%), Positives = 151/370 (40%), Gaps = 55/370 (14%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
A + LE VR L +G + ++ TAL + C+D E+ + LL++GA +N
Sbjct: 408 ACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 467
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDE----------------- 180
+PL AA GH+ L LLI GA+L VN +G P E
Sbjct: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
Query: 181 -QTLDCLETAM-----------ADRGITQDS-IEAARAVPELRM-----LDDIRSRLQAG 222
QT + ETA+ AD I + IE + P + L+ ++ L AG
Sbjct: 528 AQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAG 587
Query: 223 ADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVE 282
A++HA G T L A NG ++ A +LL+ A L + + G PL AA G V V+
Sbjct: 588 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQ 647
Query: 283 LLVAHGADLNAKSL-MDETPLDV-CGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTS 340
L++ GA++N + D T L + C + L L H D R + L+ +
Sbjct: 648 FLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE---A 704
Query: 341 SAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQQPPPTSPEPPEDNDDRQTGAELRP--- 397
+ G VV Y + + P T PP + +R ++
Sbjct: 705 AKGGHTSVV----------CYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPM 754
Query: 398 --PPPEEDNP 405
PP E D P
Sbjct: 755 VVPPQEPDKP 764
Score = 89.0 bits (219), Expect = 1e-17
Identities = 71/232 (30%), Positives = 115/232 (49%), Gaps = 17/232 (7%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L+ AA ++ V+ L + + G TAL C + ++V+ LLE+GA+I +
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDC------LET 188
TPL A + GH+ + LL+ +GA +NT N + + TL C +
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGA---GINTHSN---EFKESALTLACYKGHLEMVR 418
Query: 189 AMADRGITQD--SIEAARAVPELRM---LDDIRSRLQAGADLHAPLDHGATLLHVAAANG 243
+ + G Q+ + E A+ E M ++ R L +GA ++ P D + L +AA G
Sbjct: 419 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 478
Query: 244 FSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKS 295
E AALL+E ASL + +G+ PL AA G +V LL+ GA++NA++
Sbjct: 479 HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT 530
Score = 70.1 bits (170), Expect = 5e-12
Identities = 61/206 (29%), Positives = 105/206 (50%), Gaps = 10/206 (4%)
Query: 106 TALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLA 165
TAL C E+VQ LLE GA+I D + +TPL AAT GH+ +VE+L+ +GA++ A
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Query: 166 VN-TDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVP-----ELRMLDDIRSRL 219
+ + P L + +E +A RG ++ + P ++ I+ L
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLA-RGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1203
Query: 220 QAGADLHAPLDH--GATLLHVAAANGFSEAAALLLEHRASLSAK-DQDGWEPLHAAAYWG 276
AGA++++ G + L +AA NG + A LLL+ + ++A+ + + L A + G
Sbjct: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1263
Query: 277 QVPLVELLVAHGADLNAKSLMDETPL 302
+ +V LL+ A++ ++ TPL
Sbjct: 1264 RTEVVSLLLDRKANVEHRAKTGLTPL 1289
Score = 63.2 bits (152), Expect = 6e-10
Identities = 62/241 (25%), Positives = 106/241 (43%), Gaps = 10/241 (4%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
A A E V+ L G S + ++ G T L +V+ LL+ GA+I A
Sbjct: 1090 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 1149
Query: 138 W-TPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGIT 196
TPL A + G +VELL+A GAN N P L ++ ++ +
Sbjct: 1150 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 1209
Query: 197 QDSIEAARAVPELRM------LDDIRSRLQAGADLHAPLD-HGATLLHVAAANGFSEAAA 249
+ + L + ++ L G+D++A ++ + T L +A G +E +
Sbjct: 1210 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS 1269
Query: 250 LLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMD--ETPLDVCGD 307
LLL+ +A++ + + G PL AA G + +L+ GAD+NA + +T L + D
Sbjct: 1270 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1329
Query: 308 E 308
+
Sbjct: 1330 K 1330
Score = 62.4 bits (150), Expect = 1e-09
Identities = 65/232 (28%), Positives = 102/232 (43%), Gaps = 19/232 (8%)
Query: 85 EEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECW--TPLH 142
E V L G + + N T L + +++ LL AGA IN+ +PL
Sbjct: 1164 EVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLM 1223
Query: 143 AAATCGHLHLVELLIASGANLLA-VNTDGNMPYDLCDDEQTLDCLETAM---------AD 192
AA GH V+LL+ G+++ A + T+ N L + + + + A
Sbjct: 1224 LAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAK 1283
Query: 193 RGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGA--TLLHVAAANGFSEAAAL 250
G+T A+ E+ R L GAD++AP + T L +AA G + L
Sbjct: 1284 TGLTPLMEAASGGYAEVG-----RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1338
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPL 302
L+ A + +++ G PL AA G + +V+LLV GAD++A TPL
Sbjct: 1339 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1390
Score = 55.1 bits (131), Expect = 2e-07
Identities = 56/189 (29%), Positives = 78/189 (41%), Gaps = 32/189 (16%)
Query: 72 SVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANIN 131
S L+EAA LE V+ L +G + G TAL C + ++ LL+AGA++
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Query: 132 ACDSECWTPLHAAATCGHLHLVELLIASGANL--LAVNTDGNMPYDLCDDEQTLDCLETA 189
TPL AA GH+ V+ LI+ GAN+ N D + L A
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTV-------------LSLA 671
Query: 190 MADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAA 249
A + AV EL L GAD L G+T+L AA G +
Sbjct: 672 CAGGHL---------AVVEL--------LLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
Query: 250 LLLEHRASL 258
LL++ +L
Sbjct: 715 YLLDYPNNL 723
Score = 47.0 bits (110), Expect = 4e-05
Identities = 39/143 (27%), Positives = 61/143 (42%), Gaps = 15/143 (10%)
Query: 30 RAQQVKMWAQAEKEAQGKKGPGERPRKEAASQGLLK----------QVLFPP-----SVV 74
R + V + + + + G P EAAS G + V PP
Sbjct: 1264 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1323
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AA + + +G G D+ N+ G T L ++VQ L++AGA+++A D
Sbjct: 1324 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1383
Query: 135 SECWTPLHAAATCGHLHLVELLI 157
+ TPL AA GH+ +V L+
Sbjct: 1384 NRKITPLMAAFRKGHVKVVRYLV 1406
Score = 39.3 bits (90), Expect = 0.009
Identities = 65/280 (23%), Positives = 106/280 (37%), Gaps = 49/280 (17%)
Query: 52 ERPRKEAASQGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDG------- 104
E P E AS+ LL + ++ + LE + + G G L+ DG
Sbjct: 143 ENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIG---KLSTADGKAFADPE 199
Query: 105 ----LTALHQCCIDDFREMVQQL-LEAGANINACDSECWTPLHAAATCGHLHLVELLIAS 159
LT+ C +D+ + ++ E+ AN D+ L A + G ++ V L+
Sbjct: 200 VLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRS---LAEACSEGDVNAVRKLLIE 256
Query: 160 GANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRL 219
G ++ +G ++L CL + + Q + V + + DI
Sbjct: 257 GRSVNEHTEEG----------ESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI---- 302
Query: 220 QAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVP 279
T L AA G + LLL H+A ++A+ G L A G V
Sbjct: 303 --------------TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVD 348
Query: 280 LVELLVAHGADLNAKSLMDETPL---DVCGDEEVRAKLLE 316
+V++L+ GA + + TPL G EV LLE
Sbjct: 349 VVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLE 388
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 88.6 bits (218), Expect = 1e-17
Identities = 71/229 (31%), Positives = 107/229 (46%), Gaps = 31/229 (13%)
Query: 76 LEAAARNDLEEVRQFLGSGVSP-DLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AA N + + L +S ++A+ G +ALH E V LL GA++N CD
Sbjct: 111 LHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCD 170
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRG 194
+ PLH AA GHL +++LL+A GA+L C D + L TA A
Sbjct: 171 KKERQPLHWAAFLGHLEVLKLLVARGADL------------GCKDRKGYGLLHTAAAS-- 216
Query: 195 ITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEH 254
++ ++ L+ GA++ P G T LH+A G A L+
Sbjct: 217 ---------------GQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNA 261
Query: 255 RASLSAKDQDGWEPLHAAAYWGQVPL-VELLVAHGADLNAKSLMDETPL 302
A+++ + G+ PLH AA L +ELLV +GAD+N +S ++PL
Sbjct: 262 GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310
Score = 84.0 bits (206), Expect = 3e-16
Identities = 75/265 (28%), Positives = 118/265 (44%), Gaps = 18/265 (6%)
Query: 62 GLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQ 121
G+L PP L++A D+EEVR L + ++ +++ T LH ++Q
Sbjct: 2 GILSITDQPP---LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQ 58
Query: 122 QLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQ 181
LL +GAN+NA D+ TPLH AA + ++ LL+A A++ A + P + +
Sbjct: 59 LLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANR 118
Query: 182 TLDCLETA--------MADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGA 233
C E +ADR A L+ + L GA L+
Sbjct: 119 ATKCAEALAPLLSSLNVADR----SGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKER 174
Query: 234 TLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNA 293
LH AA G E LL+ A L KD+ G+ LH AA GQ+ +V+ L+ GA+++
Sbjct: 175 QPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDE 234
Query: 294 KSLMDETPLDVC---GDEEVRAKLL 315
+ T L + G + V +L+
Sbjct: 235 PNAFGNTALHIACYLGQDAVAIELV 259
Score = 77.4 bits (189), Expect = 3e-14
Identities = 83/262 (31%), Positives = 112/262 (42%), Gaps = 43/262 (16%)
Query: 74 VLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINAC 133
+L AAA +E V+ L G D N G TALH C + +L+ AGAN+N
Sbjct: 209 LLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQP 268
Query: 134 DSECWTPLHAAA--TCGHLHLVELLIASGANLLAVNTDGNMPYD-------------LCD 178
+ + +TPLH AA T G L L ELL+ +GA++ + +G P L
Sbjct: 269 NDKGFTPLHVAAVSTNGALCL-ELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQ 327
Query: 179 DEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHV 238
+ +DC AD+ AAR EL I + + GAD H LH+
Sbjct: 328 NGSEIDC-----ADKFGNTPLHVAARYGHELL----ISTLMTNGADTARRGIHDMFPLHL 378
Query: 239 AAANGFSEAAALLL--------------EHRAS----LSAKDQDGWEPLHAAAYWGQVPL 280
A GFS+ LL EH S ++ D G LHAAA G V
Sbjct: 379 AVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVEC 438
Query: 281 VELLVAHGADLNAKSLMDETPL 302
+ LL++ GADL + TPL
Sbjct: 439 LNLLLSSGADLRRRDKFGRTPL 460
Score = 73.6 bits (179), Expect = 4e-13
Identities = 61/212 (28%), Positives = 91/212 (42%), Gaps = 11/212 (5%)
Query: 91 LGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHL 150
+ +G + +++G + LH I Q L++ G+ I+ D TPLH AA GH
Sbjct: 293 VNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHE 352
Query: 151 HLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELR 210
L+ L+ +GA+ P L DC ++ + SI ++ + +
Sbjct: 353 LLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLY--SIVSSLSNEHV- 409
Query: 211 MLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLH 270
L AG D++ P + G T LH AA+ G E LLL A L +D+ G PLH
Sbjct: 410 --------LSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLH 461
Query: 271 AAAYWGQVPLVELLVAHGADLNAKSLMDETPL 302
AA G LV GA +N +PL
Sbjct: 462 YAAANGSYQCAVTLVTAGAGVNEADCKGCSPL 493
Score = 63.9 bits (154), Expect = 3e-10
Identities = 69/251 (27%), Positives = 102/251 (40%), Gaps = 21/251 (8%)
Query: 91 LGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGAN-INACDSEC-WTPLHAAATCG 148
L +G P L + G TA+H R+ ++ LLE N + +S +PLH AA G
Sbjct: 537 LDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNG 596
Query: 149 HLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMA--------DRGITQDSI 200
H ++ L + NL + G L + + +C+E A +R +
Sbjct: 597 HCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPL 656
Query: 201 EAARA---VPELRMLDDIRSRLQAGADLHAPLD-HGATLLHVAAANGFSEAAALLLEHRA 256
AA A L +L D R AD+ +D +G T L +A NG + LLLE +
Sbjct: 657 HAAAASGHTDSLHLLIDSGER----ADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS 712
Query: 257 SLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPL---DVCGDEEVRAK 313
+ A D G LH A G + L+ H A + + TP+ CG V
Sbjct: 713 TADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772
Query: 314 LLELKHKHDAL 324
LL+ D L
Sbjct: 773 LLQAALSTDPL 783
Score = 61.2 bits (147), Expect = 2e-09
Identities = 69/261 (26%), Positives = 103/261 (39%), Gaps = 15/261 (5%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L+ A ++ V L G + D A+ G TALH+ + + + LL+ A + D
Sbjct: 692 LMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRD 751
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANL----LAVNTDGNMPYDLCDDEQTLDCLETAM 190
+ TP+H A+ CGH ++ L+ + + V+ G P DCLE +
Sbjct: 752 FKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLL 811
Query: 191 ADRGITQDSIEAARAVP----ELRMLDDIRSRLQA--GADLHAPLD-HGATLLHVAAANG 243
+ +E P + D L GA + D G T LH AA
Sbjct: 812 EHSPFSY--LEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFAD 869
Query: 244 FSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHG-ADLNAKSLMDETPL 302
+LL+H+A ++A D G L AA GQ VE L+ G ADL T L
Sbjct: 870 NVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTAL 929
Query: 303 DV-CGDEEVRAKLLELKHKHD 322
+ C + L+ L D
Sbjct: 930 HLACSKGHEKCALMILAETQD 950
Score = 53.5 bits (127), Expect = 5e-07
Identities = 59/222 (26%), Positives = 90/222 (40%), Gaps = 19/222 (8%)
Query: 78 AAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSEC 137
AA+ ++E + L SG ++ G T LH + + L+ AGA +N D +
Sbjct: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 489
Query: 138 WTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLE--------TA 189
+PLH AA E S + + + + P ++ CLE +
Sbjct: 490 CSPLHYAAASDTYRRAEPHTPS-----SHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544
Query: 190 MADR-GITQDSIEAARAVPE-LRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEA 247
+ DR G T AA + L +L ++ + P+ + LH+AA NG EA
Sbjct: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPV----SPLHLAAYNGHCEA 600
Query: 248 AALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGA 289
L E +L +D G L A G VE+L AHGA
Sbjct: 601 LKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGA 642
Score = 52.0 bits (123), Expect = 1e-06
Identities = 64/223 (28%), Positives = 92/223 (41%), Gaps = 39/223 (17%)
Query: 123 LLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQT 182
LL+ GA+ + D + +T +H AA G+ +ELL+ N L D E T
Sbjct: 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLE------------DVEST 583
Query: 183 LDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDH-GATLLHVAAA 241
+ +A EA + + E + D+R DH G T L +A
Sbjct: 584 IPVSPLHLA---AYNGHCEALKTLAETLVNLDVR-------------DHKGRTALFLATE 627
Query: 242 NGFSEAAALLLEHRASLSAKDQD-GWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMD-- 298
G +E +L H AS K++ W PLHAAA G + LL+ G + +MD
Sbjct: 628 RGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAY 687
Query: 299 -ETPLDVC---GDEEVRAKLLELKHKHDALLRAQSRQRSLLRR 337
+TPL + G + LLE DA A R R+ L R
Sbjct: 688 GQTPLMLAIMNGHVDCVHLLLEKGSTADA---ADLRGRTALHR 727
Score = 51.2 bits (121), Expect = 2e-06
Identities = 54/202 (26%), Positives = 80/202 (39%), Gaps = 30/202 (14%)
Query: 76 LEAAARNDLEEVRQFLGSGVSPDLANE---DGLTALHQCCIDDFREMVQQLLEAGANINA 132
L A N+ + + L + + N G T LH D ++ LL+ A +NA
Sbjct: 827 LHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNA 886
Query: 133 CDSECWTPLHAAATCGHLHLVELLIASG-ANLLAVNTDGNMPYDLCDDEQTLDCLETAMA 191
D T L AA G VE L+ G A+L ++ + N L + C +A
Sbjct: 887 TDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILA 946
Query: 192 DRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALL 251
+ TQD L +++ S LQ LH+AA NG + L
Sbjct: 947 E---TQD----------LGLINATNSALQMP-------------LHIAARNGLASVVQAL 980
Query: 252 LEHRASLSAKDQDGWEPLHAAA 273
L H A++ A D++G P A A
Sbjct: 981 LSHGATVLAVDEEGHTPALACA 1002
Score = 48.9 bits (115), Expect = 1e-05
Identities = 57/217 (26%), Positives = 89/217 (41%), Gaps = 33/217 (15%)
Query: 106 TALHQCCIDDFREMVQQLLEA-GANI-NACDSECWTPLHAAATCGHLHLVELLIASGANL 163
T LH I++ + LL A GA I N+ D++ TPLHAAA ++ + +L+ A +
Sbjct: 825 TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEV 884
Query: 164 LAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGA 223
A + G L TA + R +L +LD+ ++
Sbjct: 885 NATDHTGRT------------ALMTAAENGQTAAVEFLLYRGKADLTVLDENKN------ 926
Query: 224 DLHAPLDHGATLLHVAAANGFSEAAALLLEHRASL---SAKDQDGWEPLHAAAYWGQVPL 280
T LH+A + G + A ++L L +A + PLH AA G +
Sbjct: 927 ----------TALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASV 976
Query: 281 VELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLEL 317
V+ L++HGA + A TP C + A L L
Sbjct: 977 VQALLSHGATVLAVDEEGHTPALACAPNKDVADCLAL 1013
Score = 47.4 bits (111), Expect = 3e-05
Identities = 38/117 (32%), Positives = 55/117 (47%), Gaps = 6/117 (5%)
Query: 76 LEAAARNDLEEVRQFLGSGVSPDLA--NEDGLTALHQCCIDDFREMVQQLLEAGAN---I 130
L AA N +FL DL +E+ TALH C + +L + I
Sbjct: 895 LMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLI 954
Query: 131 NACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLC-DDEQTLDCL 186
NA +S PLH AA G +V+ L++ GA +LAV+ +G+ P C ++ DCL
Sbjct: 955 NATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCL 1011
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 88.2 bits (217), Expect = 2e-17
Identities = 113/420 (26%), Positives = 173/420 (41%), Gaps = 65/420 (15%)
Query: 51 GERPRKEAASQGLLK--QVL-------------FPPSVVLLEAAARNDLEEVRQFLGSGV 95
G P EAAS G ++ +VL F S + L A + L+ VR L +G
Sbjct: 338 GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTL-ACYKGHLDMVRFLLEAGA 396
Query: 96 SPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVEL 155
+ ++ TAL + C+D E+ + LL++GA +N +PL AA GH+ L L
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
Query: 156 LIASGANLLAVNTDGNMPYDLCDDE------------------QTLDCLETAM------- 190
LI GANL VN +G P E QT + ETA+
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516
Query: 191 ----ADRGITQDS-IEAARAVPELRM-----LDDIRSRLQAGADLHAPLDHGATLLHVAA 240
AD I + IE + P + L+ ++ L +GA++HA G T L A
Sbjct: 517 FSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576
Query: 241 ANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLN-AKSLMDE 299
NG ++ A +LL+ A L + + G PL AA G + V+ L++ GA++N A + D
Sbjct: 577 ENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDH 636
Query: 300 TPLDV-CGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRT 358
T + + C + L L H D R + L+ ++ G VV +
Sbjct: 637 TVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE---AAKGGHTNVVSYLLDYPNN 693
Query: 359 DLYRKQHAQEAIVWQQPPPTSPEPPEDNDDRQTGAELRPP-----PPEEDNPEVVRPHNG 413
L V Q PPP+ + T A + PP +E++P ++ G
Sbjct: 694 VL----SVPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKG 749
Score = 87.8 bits (216), Expect = 2e-17
Identities = 72/232 (31%), Positives = 115/232 (49%), Gaps = 17/232 (7%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L+ A++ L+ V+ L + + G TAL C F ++V+ LL GANI +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDC------LET 188
TPL AA+ GH+ + +L+ GA +NT N + + TL C +
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGA---GINTHSN---EFKESALTLACYKGHLDMVR 389
Query: 189 AMADRGITQD--SIEAARAVPELRM---LDDIRSRLQAGADLHAPLDHGATLLHVAAANG 243
+ + G Q+ + E A+ E M ++ R L +GA ++ P D + L +AA G
Sbjct: 390 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 449
Query: 244 FSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKS 295
E AALL+E A+L + +G+ PL AA G +V LL+A GA++NA++
Sbjct: 450 HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Score = 70.9 bits (172), Expect = 3e-12
Identities = 80/283 (28%), Positives = 119/283 (42%), Gaps = 42/283 (14%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANI-NAC 133
L EA + D+ VR+ L G S + E+G + L C + E+ Q LL AN+ +
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 134 DSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADR 193
+ TPL AA++ G+L +V+LL+ A++ + + GN +D ++ + +
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 194 GITQDS--------IEAARA--VPELRM----------------------------LDDI 215
+D +EAA A V R+ LD +
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 216 RSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYW 275
R L+AGAD D T L A +G E A LLL+ A ++ PL AA
Sbjct: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
Query: 276 GQVPLVELLVAHGADLNAKSLMDETPLDVC---GDEEVRAKLL 315
G V L LL+ GA+L + TPL G EE+ A LL
Sbjct: 449 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491
Score = 61.2 bits (147), Expect = 2e-09
Identities = 64/232 (27%), Positives = 102/232 (43%), Gaps = 19/232 (8%)
Query: 85 EEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECW--TPLH 142
E V L G + + N T L + +++ LL AGA IN+ +PL
Sbjct: 1136 EVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLM 1195
Query: 143 AAATCGHLHLVELLIASGANLLA-VNTDGNMPYDLCDDEQTLDCLETAM---------AD 192
AA GH+ V+LL+ G+++ A + T+ N L + + + + A
Sbjct: 1196 LAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAK 1255
Query: 193 RGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGA--TLLHVAAANGFSEAAAL 250
G+T A+ E+ R L GAD++AP + T L +AA G + L
Sbjct: 1256 TGLTPLMEAASGGYAEVG-----RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1310
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPL 302
L+ A + +++ G PL A+ G +V+LLV GAD++A TPL
Sbjct: 1311 LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362
Score = 59.7 bits (143), Expect = 6e-09
Identities = 55/191 (28%), Positives = 86/191 (45%), Gaps = 30/191 (15%)
Query: 106 TALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLA 165
TAL C E+V L+ A I D + +TPL AAT GH+ +VE+L+ G ++ A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 166 VNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADL 225
E+T D ++A G Q+ ++ L GA+
Sbjct: 1117 ------------QSERTKD-TPLSLACSGGRQEVVDLL---------------LARGANK 1148
Query: 226 HAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAK--DQDGWEPLHAAAYWGQVPLVEL 283
T L +AA+ G+ +LL A ++++ + G PL AA G VP V+L
Sbjct: 1149 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKL 1208
Query: 284 LVAHGADLNAK 294
L+ G+D+NA+
Sbjct: 1209 LLDMGSDINAQ 1219
Score = 59.3 bits (142), Expect = 8e-09
Identities = 51/189 (26%), Positives = 81/189 (42%), Gaps = 28/189 (14%)
Query: 107 ALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAV 166
+L + C D V++LL+ G ++N E + L A + G+ L ++L+A AN+
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV--- 264
Query: 167 NTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLH 226
DRG D I A LD ++ L AD++
Sbjct: 265 ------------------------EDRGNKGD-ITPLMAASSGGYLDIVKLLLLHDADVN 299
Query: 227 APLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVA 286
+ G T L A A GF + +LL A++ +++G PL AA G V + +L+
Sbjct: 300 SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLD 359
Query: 287 HGADLNAKS 295
HGA +N S
Sbjct: 360 HGAGINTHS 368
Score = 49.3 bits (116), Expect = 9e-06
Identities = 47/157 (29%), Positives = 74/157 (47%), Gaps = 18/157 (11%)
Query: 163 LLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAG 222
+ AV+T +P QT +CL + S A++++P + DI
Sbjct: 1000 IAAVST--RVPTGSNSSSQTTECLTPESCSQ---TTSNVASQSMPPVYPSVDI------- 1047
Query: 223 ADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVE 282
D H +H T L +A A G E ++L+ A + +D+ G+ PL AA G V +VE
Sbjct: 1048 -DAHTESNHD-TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
Query: 283 LLVAHGADLNAKS-LMDETPLDVC---GDEEVRAKLL 315
+L+ G D+ A+S +TPL + G +EV LL
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLL 1142
Score = 44.3 bits (103), Expect = 3e-04
Identities = 38/143 (26%), Positives = 62/143 (43%), Gaps = 15/143 (10%)
Query: 30 RAQQVKMWAQAEKEAQGKKGPGERPRKEAASQGLLK----------QVLFPP-----SVV 74
RA+ V + + + + G P EAAS G + V PP
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AA + + + G D+ N+ G T L ++VQ L++AGA+++A D
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
Query: 135 SECWTPLHAAATCGHLHLVELLI 157
+ TPL +A GH+ +V+ L+
Sbjct: 1356 NRKITPLMSAFRKGHVKVVQYLV 1378
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 88.2 bits (217), Expect = 2e-17
Identities = 113/420 (26%), Positives = 173/420 (41%), Gaps = 65/420 (15%)
Query: 51 GERPRKEAASQGLLK--QVL-------------FPPSVVLLEAAARNDLEEVRQFLGSGV 95
G P EAAS G ++ +VL F S + L A + L+ VR L +G
Sbjct: 338 GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTL-ACYKGHLDMVRFLLEAGA 396
Query: 96 SPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVEL 155
+ ++ TAL + C+D E+ + LL++GA +N +PL AA GH+ L L
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
Query: 156 LIASGANLLAVNTDGNMPYDLCDDE------------------QTLDCLETAM------- 190
LI GANL VN +G P E QT + ETA+
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516
Query: 191 ----ADRGITQDS-IEAARAVPELRM-----LDDIRSRLQAGADLHAPLDHGATLLHVAA 240
AD I + IE + P + L+ ++ L +GA++HA G T L A
Sbjct: 517 FSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576
Query: 241 ANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLN-AKSLMDE 299
NG ++ A +LL+ A L + + G PL AA G + V+ L++ GA++N A + D
Sbjct: 577 ENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDH 636
Query: 300 TPLDV-CGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRT 358
T + + C + L L H D R + L+ ++ G VV +
Sbjct: 637 TVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE---AAKGGHTNVVSYLLDYPNN 693
Query: 359 DLYRKQHAQEAIVWQQPPPTSPEPPEDNDDRQTGAELRPP-----PPEEDNPEVVRPHNG 413
L V Q PPP+ + T A + PP +E++P ++ G
Sbjct: 694 VL----SVPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKG 749
Score = 87.8 bits (216), Expect = 2e-17
Identities = 72/232 (31%), Positives = 115/232 (49%), Gaps = 17/232 (7%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L+ A++ L+ V+ L + + G TAL C F ++V+ LL GANI +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDC------LET 188
TPL AA+ GH+ + +L+ GA +NT N + + TL C +
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGA---GINTHSN---EFKESALTLACYKGHLDMVR 389
Query: 189 AMADRGITQD--SIEAARAVPELRM---LDDIRSRLQAGADLHAPLDHGATLLHVAAANG 243
+ + G Q+ + E A+ E M ++ R L +GA ++ P D + L +AA G
Sbjct: 390 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 449
Query: 244 FSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKS 295
E AALL+E A+L + +G+ PL AA G +V LL+A GA++NA++
Sbjct: 450 HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Score = 70.9 bits (172), Expect = 3e-12
Identities = 80/283 (28%), Positives = 119/283 (42%), Gaps = 42/283 (14%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANI-NAC 133
L EA + D+ VR+ L G S + E+G + L C + E+ Q LL AN+ +
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 134 DSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADR 193
+ TPL AA++ G+L +V+LL+ A++ + + GN +D ++ + +
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 194 GITQDS--------IEAARA--VPELRM----------------------------LDDI 215
+D +EAA A V R+ LD +
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 216 RSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYW 275
R L+AGAD D T L A +G E A LLL+ A ++ PL AA
Sbjct: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
Query: 276 GQVPLVELLVAHGADLNAKSLMDETPLDVC---GDEEVRAKLL 315
G V L LL+ GA+L + TPL G EE+ A LL
Sbjct: 449 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491
Score = 61.2 bits (147), Expect = 2e-09
Identities = 64/232 (27%), Positives = 102/232 (43%), Gaps = 19/232 (8%)
Query: 85 EEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECW--TPLH 142
E V L G + + N T L + +++ LL AGA IN+ +PL
Sbjct: 1136 EVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLM 1195
Query: 143 AAATCGHLHLVELLIASGANLLA-VNTDGNMPYDLCDDEQTLDCLETAM---------AD 192
AA GH+ V+LL+ G+++ A + T+ N L + + + + A
Sbjct: 1196 LAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAK 1255
Query: 193 RGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGA--TLLHVAAANGFSEAAAL 250
G+T A+ E+ R L GAD++AP + T L +AA G + L
Sbjct: 1256 TGLTPLMEAASGGYAEVG-----RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1310
Query: 251 LLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPL 302
L+ A + +++ G PL A+ G +V+LLV GAD++A TPL
Sbjct: 1311 LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362
Score = 59.7 bits (143), Expect = 6e-09
Identities = 55/191 (28%), Positives = 86/191 (45%), Gaps = 30/191 (15%)
Query: 106 TALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLA 165
TAL C E+V L+ A I D + +TPL AAT GH+ +VE+L+ G ++ A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 166 VNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADL 225
E+T D ++A G Q+ ++ L GA+
Sbjct: 1117 ------------QSERTKD-TPLSLACSGGRQEVVDLL---------------LARGANK 1148
Query: 226 HAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAK--DQDGWEPLHAAAYWGQVPLVEL 283
T L +AA+ G+ +LL A ++++ + G PL AA G VP V+L
Sbjct: 1149 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKL 1208
Query: 284 LVAHGADLNAK 294
L+ G+D+NA+
Sbjct: 1209 LLDMGSDINAQ 1219
Score = 59.3 bits (142), Expect = 8e-09
Identities = 51/189 (26%), Positives = 81/189 (42%), Gaps = 28/189 (14%)
Query: 107 ALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAV 166
+L + C D V++LL+ G ++N E + L A + G+ L ++L+A AN+
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV--- 264
Query: 167 NTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLH 226
DRG D I A LD ++ L AD++
Sbjct: 265 ------------------------EDRGNKGD-ITPLMAASSGGYLDIVKLLLLHDADVN 299
Query: 227 APLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVA 286
+ G T L A A GF + +LL A++ +++G PL AA G V + +L+
Sbjct: 300 SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLD 359
Query: 287 HGADLNAKS 295
HGA +N S
Sbjct: 360 HGAGINTHS 368
Score = 49.3 bits (116), Expect = 9e-06
Identities = 47/157 (29%), Positives = 74/157 (47%), Gaps = 18/157 (11%)
Query: 163 LLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAG 222
+ AV+T +P QT +CL + S A++++P + DI
Sbjct: 1000 IAAVST--RVPTGSNSSSQTTECLTPESCSQ---TTSNVASQSMPPVYPSVDI------- 1047
Query: 223 ADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVE 282
D H +H T L +A A G E ++L+ A + +D+ G+ PL AA G V +VE
Sbjct: 1048 -DAHTESNHD-TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
Query: 283 LLVAHGADLNAKS-LMDETPLDVC---GDEEVRAKLL 315
+L+ G D+ A+S +TPL + G +EV LL
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLL 1142
Score = 44.3 bits (103), Expect = 3e-04
Identities = 38/143 (26%), Positives = 62/143 (43%), Gaps = 15/143 (10%)
Query: 30 RAQQVKMWAQAEKEAQGKKGPGERPRKEAASQGLLK----------QVLFPP-----SVV 74
RA+ V + + + + G P EAAS G + V PP
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L AA + + + G D+ N+ G T L ++VQ L++AGA+++A D
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
Query: 135 SECWTPLHAAATCGHLHLVELLI 157
+ TPL +A GH+ +V+ L+
Sbjct: 1356 NRKITPLMSAFRKGHVKVVQYLV 1378
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 87.8 bits (216), Expect = 2e-17
Identities = 72/232 (31%), Positives = 115/232 (49%), Gaps = 17/232 (7%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
L+ A++ L+ V+ L + + G TAL C F ++V+ LL GANI +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 135 SECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDC------LET 188
TPL AA+ GH+ + +L+ GA +NT N + + TL C +
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGA---GINTHSN---EFKESALTLACYKGHLDMVR 389
Query: 189 AMADRGITQD--SIEAARAVPELRM---LDDIRSRLQAGADLHAPLDHGATLLHVAAANG 243
+ + G Q+ + E A+ E M ++ R L +GA ++ P D + L +AA G
Sbjct: 390 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 449
Query: 244 FSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKS 295
E AALL+E A+L + +G+ PL AA G +V LL+A GA++NA++
Sbjct: 450 HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Score = 77.8 bits (190), Expect = 2e-14
Identities = 79/268 (29%), Positives = 119/268 (44%), Gaps = 49/268 (18%)
Query: 51 GERPRKEAASQGLLK--QVL-------------FPPSVVLLEAAARNDLEEVRQFLGSGV 95
G P EAAS G ++ +VL F S + L A + L+ VR L +G
Sbjct: 338 GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTL-ACYKGHLDMVRFLLEAGA 396
Query: 96 SPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVEL 155
+ ++ TAL + C+D E+ + LL++GA +N +PL AA GH+ L L
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
Query: 156 LIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDI 215
LI GANL VN +G P +EAAR E + +
Sbjct: 457 LIERGANLEEVNDEGYTPL-------------------------MEAAREGHE----EMV 487
Query: 216 RSRLQAGADLHAPLDH-GATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAY 274
L GA+++A + T L +A GFSE A L++ A + PL A+
Sbjct: 488 ALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQ 544
Query: 275 WGQVPLVELLVAHGADLNAKSLMDETPL 302
G + LV+ L+A GA+++A + +T L
Sbjct: 545 EGHLELVKYLLASGANVHATTATGDTAL 572
Score = 70.9 bits (172), Expect = 3e-12
Identities = 80/283 (28%), Positives = 119/283 (42%), Gaps = 42/283 (14%)
Query: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANI-NAC 133
L EA + D+ VR+ L G S + E+G + L C + E+ Q LL AN+ +
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 134 DSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADR 193
+ TPL AA++ G+L +V+LL+ A++ + + GN +D ++ + +
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 194 GITQDS--------IEAARA--VPELRM----------------------------LDDI 215
+D +EAA A V R+ LD +
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 216 RSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYW 275
R L+AGAD D T L A +G E A LLL+ A ++ PL AA
Sbjct: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
Query: 276 GQVPLVELLVAHGADLNAKSLMDETPLDVC---GDEEVRAKLL 315
G V L LL+ GA+L + TPL G EE+ A LL
Sbjct: 449 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491
Score = 59.3 bits (142), Expect = 8e-09
Identities = 51/189 (26%), Positives = 81/189 (42%), Gaps = 28/189 (14%)
Query: 107 ALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAV 166
+L + C D V++LL+ G ++N E + L A + G+ L ++L+A AN+
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV--- 264
Query: 167 NTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLH 226
DRG D I A LD ++ L AD++
Sbjct: 265 ------------------------EDRGNKGD-ITPLMAASSGGYLDIVKLLLLHDADVN 299
Query: 227 APLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVA 286
+ G T L A A GF + +LL A++ +++G PL AA G V + +L+
Sbjct: 300 SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLD 359
Query: 287 HGADLNAKS 295
HGA +N S
Sbjct: 360 HGAGINTHS 368
Score = 35.8 bits (81), Expect = 0.099
Identities = 20/60 (33%), Positives = 31/60 (51%)
Query: 72 SVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANIN 131
S L+EA+ LE V+ L SG + G TAL C + ++ LL+AGA+++
Sbjct: 536 STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 34.3 bits (77), Expect = 0.29
Identities = 19/58 (32%), Positives = 33/58 (56%)
Query: 106 TALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANL 163
T L + + E+V+ LL +GAN++A + T L A GH + ++L+ +GA+L
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,797,525
Number of Sequences: 37866
Number of extensions: 1323434
Number of successful extensions: 12808
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 400
Number of HSP's successfully gapped in prelim test: 227
Number of HSP's that attempted gapping in prelim test: 7918
Number of HSP's gapped (non-prelim): 3105
length of query: 528
length of database: 18,247,518
effective HSP length: 107
effective length of query: 421
effective length of database: 14,195,856
effective search space: 5976455376
effective search space used: 5976455376
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.